Gene PRL in Monosiga brevicollis

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family DSP
Subfamily PRL
Protein sequence
ID Type Fasta BLAST phosphatome Note
MbreP013_AA protein Get Run
MbreP013_AA_6-153 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_PRL_pd Subfamily PRL 7-154 1.7e-73 239.7 In-house 3-150 (151) alignment 
Range on Protein: 7-154
Range on HMM: 3-150/151.0
SKISHKNMRFLITDRPSDATVEDYVRVLQQENVVALCRVCEPSYDVSKLKDNGIEVHDWAFQDGAPPPDEVIDNWLRLCRETFAQHPNGFVAVHCVAGLG
..|..|.|||||||||.|||.|.... |..|.| ...|||||.||..||...||||.|.||.|||.||.||...||.|..|.|...|. .||||||||||
veieykkmrflitdrPtdatlekfieelkkeevktvvrvceptydteklekegievldlafddGavPpeevveeWlellkekfkeepkstvavhcvaGlG

RAPVLVALSLIEAGMSSEDAVLFIREKRHGAINRRQLQFLQDYKRRGK
||||||||.||||||..|||| ||||||.||||..||.||..||.. |
raPvlvalalieaGmkyedavefirekrrgainskqlkflekykakkk
0043147 (Phosphotyrosine protein) phosphatases II 9-151 1.5e-36 121.1 In-house 15-158 (172) alignment 
Range on Protein: 9-151
Range on HMM: 15-158/172.0
ISHKNMRFLITDRPSDATVEDYVRVLQQENVVALCRVCEPSYDVSKLKDNGIEVHDWAFQDGAPPPDEVIDNWLRLCRETFAQHPNGFVAVHCVAGLGRA
.... .||..|  | . |..|..| |..... .. ...|  || ..|...||... . . |. .|. |.....|....| .|. |.| |.|||.||.||.
lyyipdrfiatqgplrntladfwrmlkelgithivnltellydpellerlgiqylylpwpDhgvpllellleflefidellalspggpvlVHCsaGvgRt

PVLVALSLIEAGMSSEDAVLFIREKRHGAI-NRRQLQFLQDYKR
..|||. |.. |.| |.|| ..|||| ||. |  |..||... .
gtlvaaylmllglsleeavalvrekRpgavqnpsqyrflyyfek
0038934 (Phosphotyrosine protein) phosphatases II 15-152 5.7e-36 119.4 In-house 19-172 (194) alignment 
Range on Protein: 15-152
Range on HMM: 19-172/194.0
RFLITDRPSDATVEDYVRVLQQENVVALCRVC----------------EPSYDVSKLKDNGIEVHDWAFQD-GAPPPDEVIDNWLRLCRETFAQHPNGFV
||.....|.. ....|.  |.. ..  |.|..                |. ||.......|||.... | | |..|..|.....|.|. | ....|.| |
rfiafkvPlsgsldkyieelyrfspedlvrylkllnvklglvidltnteryYdpeefekagieylklpfpddgtvPsleillrfldlvdeflnedpggvv

AVHCVAGLGRAPVLVALSLIE-AGMSSEDAVLFIREKRHGAInrRQLQFLQDYKRR
||||.|||||...|||  ||.  ||| |.|. ..|||| |||  .. ..|... .|
aVHCkaGlgRtGtlvaaYLiyrlgmsaeeAialfrekRpgai..pnqdyleallkr
0049260 (Phosphotyrosine protein) phosphatases II 11-150 8.5e-34 111.8 In-house 6-146 (152) alignment 
Range on Protein: 11-150
Range on HMM: 6-146/152.0
HKNMRFLITDRPSDATVEDYVRVLQQENVVALCRVCEPSYDVSKLKDNGIEVHDWAFQDGAPPPDEVIDNWLRLCRETFAQHPNGFVAVHCVAGLGRAPV
.....|..|  | . |..|..| |.. .. .. ...|....     ...|... . . |. .|... .  .| |  | .|....| |.|||.||.||...
ampfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyiqylhlpwpDhgvpdlsqlllflllfieklaldkggpvlVHCsaGvgRtgt

LVALSLIEAGMSSEDAVLFIREKRHGAI-NRRQLQFLQDYK
|||. |.. |.| |.|| ..|||| ||. |  ||.||... 
lvaaylmllgvsleeavalvrekRpgavpnpgqlrflyefe
0040439 (Phosphotyrosine protein) phosphatases II 9-149 3.6e-32 107.4 In-house 49-241 (249) alignment 
Range on Protein: 9-149
Range on HMM: 49-241/249.0
ISHKNMRFLITDRPSDATVEDYVRVLQQENVVALCRVCEPS---------------------------------------------YDVSKLKDNGIEVH
 .. ..||..|. | . ||||. | |..... ........                                              || .... ..| ..
gyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywplggsleygdftvtllsvevkddytvrtleltnlydgesrtvlhiqyt

DWAfQDGAPPPDEVIDNWLRLCRETFAQH-PNGFVAVHCVAGLGRAPVLVALSLI------EAGMSSEDAVLFIREKRHGAI-NRRQLQFLQDY
||   .|.||  | ........|. ...  ..| |.||| ||.||.....|. |.      | |.. |.|| ..|..|.||. |  |..||...
dwp.dhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaaylmleqlekelgvdleeavkllrsqRpgavqnpeqyrflyea
0046846 (Phosphotyrosine protein) phosphatases II 15-151 1.9e-31 104.6 In-house 24-170 (176) alignment 
Range on Protein: 15-151
Range on HMM: 24-170/176.0
RFLITDRPSDATVEDYVRVLQQENVVALCRVCEP--------SYDVSKLKDNGIEVHDWAFQDGAPPPDEVIDNWLRLCRETFAQHpnGFVAVHCVAGLG
|...|. |   |..|... |..... |. ...|.         .. . |...||... . . |. .|..| ....|...||   ..  | |.|||.||.|
rpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgiqylhlpwpDhgvpdlelllellefirealkeg..gpvlVHCsaGig

RAPVLVALSLIEA--GMSSEDAVLFIREKRH-GAI-NRRQLQFLQDYKR
|...|||. |.|   |.| |.|. ..||.|. ||. .. |..||... .
RtgtlvaayllelekglsveealalvreqRplgavqtpeQyrflyefel
0045450 (Phosphotyrosine protein) phosphatases II 8-149 6.9e-31 103.5 In-house 101-299 (307) alignment 
Range on Protein: 8-149
Range on HMM: 101-299/307.0
KISHKNMRFLITDRPSDATVEDYVRVLQQENVVALCRVCEPSYDVSK------------------------------------------LKDNGIEVHDW
.. .....|..|. | . ||||. | |....| ......|. .. ..                                           ......|. .
dgydlkrkfIatqgPlpetvedFwrmlweqgvtvivmltelvelgrekcaqywPdegeeltygnftvtllseehldgytvrtlevtdldgtgesrtvthf

AF---QDGAPPPD-EVIDNWLRLCRETFAQH-PNGFVAVHCVAGLGRAPVLVALSLIEAG---------MSSEDAVLFIREKRHGAI-NRRQLQFLQDY
 .    |.  ||. | . ......|. .... ..| |.||| ||.||.....|. |.  .         .. ..|| ..||.|.||. |  |..||...
hytgwpdhgvppsfeelldfieevrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyea
0045098 (Phosphotyrosine protein) phosphatases II 8-150 1.5e-30 101.9 In-house 61-268 (278) alignment 
Range on Protein: 8-150
Range on HMM: 61-268/278.0
KIshkNMRFLITDRPSDATVEDYVRVLQQENVVALCRVCEPSYD------------------------------------------V----SKLKDNGIE
     ...|..|. | . ||.|. | |..... ......|  ..                                          .    . |. .|..
gy...pkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrekcaqywpeggsltygdftvtllseevlddytlrtllvtnltveredlesrgvt

VHDW-AFQDGAPPPDEVIDNWLRLCRETFAQH---------------PNGFVAVHCVAGLGRAPVLVALSLIEA----GMSSEDAVLFIREKRHG-AI-N
....  . |. .|...... .|.|...  . .               ..| |.||| ||.||. .|||. |.      |.. ..|| ..|..|.| |. |
hlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsggpvlVHCsaGvgRtGtlvaaylmlelleggvdlleavkelrsqRpglavqn

RRQLQFLQDYK
  |..|| .. 
leqyrflyefl
0041856 (Phosphotyrosine protein) phosphatases II 9-149 2e-30 101.2 In-house 29-165 (182) alignment 
Range on Protein: 9-149
Range on HMM: 29-165/182.0
ISHKNMRFLITDRPSDATVEDYVRVLQQENVVALCRVCEPSYDVSKLKDNGIEVHDWAFQDGAPPPDEVIDNWLRLCREtfaqhPNGFVAVHCVAGLGRA
 |....||..| .| . ||.|..| |..... .. ...|. |. ..|...||..... . |. .|. . . .... ..|     ..| |.||| ||.||.
gslpatrfiatqgpllstvadflrmlkelgittivnlteelywpellerlgiqylylpwpDhgvpdldelldfieevle.....eggpvlVHCsaGvgRt

PVLVALSLIE-AGMSSEDAVLFIREKRHGAINRRQLQFLQDY
..|||. |..  |.| |.|| ..|..|.|.. . .  |.  .
gtlvaaylmkklgvsleeavklvrsrRpgmvitpnqyfflql
0039614 (Phosphotyrosine protein) phosphatases II 6-149 1.5e-29 98.8 In-house 93-284 (297) alignment 
Range on Protein: 6-149
Range on HMM: 93-284/297.0
ISKISHKNMRFLITDRPSDATVEDYVRVLQQENVVALCRVCEPSYD----------------------VSKLKDNGIE-------------------VHD
..  .. ...|..|  |.. ||||. | .....| .. ..... ..                      ..  ...|.                    ...
vdgydlltrkfIatqgPlpetvedFwrmvweqgvtvivmLtklvelgrkcaqywpeeggtygdftvtllkvehldgytvrtlevtnngesrtvthfqytg

WAfQDGAPPPDEVIDNWLRLCRETFAQH-PNGFVAVHCVAGLGRAPVLVALSLI------EAGMSSEDAVLFIREKRHGAI-NRRQLQFLQDY
|   .|.||  |.....|.|.|| .|.  ..| |.|||.||.||. ...|. |.      | |.. ..|| ..||.|.||. .  |..||.|.
wp.dhgvppslellleflelvrealaelpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflyda
0042113 (Phosphotyrosine protein) phosphatases II 9-149 1.5e-29 98.5 In-house 47-238 (245) alignment 
Range on Protein: 9-149
Range on HMM: 47-238/245.0
ISHKNMRFLITDRPSDATVEDYVRVLQQENVVALCRVCEPSYD-------------------------------------------VSKLKDNGIEVHDW
 .. . .|..|. |.. ||||. | |..... ......|. ..                                            .. . ..| .|  
gyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywplgesltygdftvtllseehlddytvrtlevtnlgddesrevihyhyl

AFQDGAPPP-DEVIDNWLRLCRETFAQHPNGFVAVHCVAGLGRAPVLVALSLI------EAGMSSEDAVLFIREKRHGAI-NRRQLQFLQDY
 . |. .|. .| ....|...|.  |...|| |.||| ||.||. ...|. |.      | |.| |.|| ..|..|.||. .  |..||...
pwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylmleqlekelgvsleeavkelrsqRpgavqtpsqyrflyea
0036282 (Phosphotyrosine protein) phosphatases II 10-151 5.5e-29 96.5 In-house 13-167 (174) alignment 
Range on Protein: 10-151
Range on HMM: 13-167/174.0
SHKNMRFLITDRPSDatvedYVRVLQQENVVALCRVCEPSYDV------------SKLKDNGIEVHDWAFQDGAPPPDEVIDNWLRLCRETFAQHPNGFV
|. . |..... | .     ... |..... .. ...|. ..             . |...||..... . |. .|.............| ....|.| |
syitprliagqgpla.....fwemlkelgittvvmlleekelglykcinywpelredlerlgiqylylpwpDhgvpdlsillefvkfveealsedpggpv

AVHCVAGLGRAPVLVALSLIEAGM--SSEDAVLFIREKR----HGAINRRQLQFLQDYKR
.||| ||.||...|||. |.. |.  | .||. ..||.|    .. ..  |..||.....
lVHCsaGvgRtGtlvaaylmlrglleslvdaldlvrelRlqrpgmvqtpsQyrflyyfek
0043336 (Phosphotyrosine protein) phosphatases II 9-149 1.5e-28 95.5 In-house 83-272 (278) alignment 
Range on Protein: 9-149
Range on HMM: 83-272/278.0
ISHKNMRFLITDRPSDATVEDYVRVLQQENVVALCRVCEPS--------------------------------------------YDVSKLKDNGIEVHD
  .....|..|  |.. ||||. | .....|  . ...|.                                             .|  ... ...  ..
gynvprkfiatqgPlpetvedFwrmvwelgvttivmLtelvelgrvkcaqYwpggsltygdftvtllkeehlddytvrtlevtnlgdgesrtvthyhylg

WAfQDGAPPPDEVIDNWLRLCRETFAqHPNGFVAVHCVAGLGRAPVLVALSLI------EAGMSSEDAVLFIREKRHGAI-NRRQLQFLQDY
|   .|.|.. . . ..|.  || .. ..|| |.|||.||.||. ...|| |.      | |.. |.|| ..||.|.||. .  |..|| ..
wp.dhgvpeslsllldflkavreale.dsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflyea
0044763 (Phosphotyrosine protein) phosphatases II 5-153 6.4e-28 93.0 In-house 22-170 (178) alignment 
Range on Protein: 5-153
Range on HMM: 22-170/178.0
HISKISHKnmrFLITDRPSdatvEDYVRVLQQENVVALCRVCEPSY------DVSKLKDNGIEVHDWAFQDGAPPP-DEVIDNWLRLCRETFAqHPNGFV
..|.| .    ..... |.    .|... |..... ......|. .      |   ....||... . . |. .|. .| .........|  .  ..| |
naseilpg...lylgslpp....addlellkelgithivnlteelelgflkcdpywpeeagiqylhipipDhgvpdllehflefvefieeald.ekggpv

AVHCVAGLGRAPVLVALSLI-EAGMSSEDAVLFIREKRHGAINRRQLQFLQDYKRRG
.||| ||.||...|||. |. . |.| |.|. ..||.| . .|. ||..|... .| 
lVHCsaGvgRsgtlvaaylmkklglsleeaielvrerRpivpnpgqlrqLyefelrl
0037934 (Phosphotyrosine protein) phosphatases II 15-149 1.3e-27 92.4 In-house 45-237 (243) alignment 
Range on Protein: 15-149
Range on HMM: 45-237/243.0
RFLITDRPSDATVED----YVRVLQQENVVALCRVCEPS------------------------------------------YDVSKLKDNGIEVHDWAFQ
|. .|. | . ||||    ..| |..... ... ..|.                                           .| ..|. ..| .| ... 
rliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywpgevtygdftvtllseehlddytvrtlllenldlddltrlvihyhylpwp

DGAPPP-DEVIDNWLRLCRETFAQ-------HPNGFVAVHCVAGLGRAPVLVALSLIEA--GMSSEDAVLFIREKRHG-AI-NRRQLQFLQDY
|. .|.  | . ..|. .||   .       ...| |.|||.||.||. .|.|. |.    |.. |.|| ..||.|.| |. .. |..||...
dhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRtGtliaaylmllllgvdleeavkllreqRpgkavqtpsqyrflyea
0040438 (Phosphotyrosine protein) phosphatases II 8-149 5.5e-27 90.3 In-house 80-271 (317) alignment 
Range on Protein: 8-149
Range on HMM: 80-271/317.0
KISHKNMRFLITDRPSDATVEDYVRVLQQENVVALCRVCEPSYD------------------------VSKLKDNGIEVHDWAF----------------
.. .....|..|  | . ||||. | .....|  . ...|. ..                        .|  ...||...   .                
dgpnlkrkfIatqgPlpntvedFwrmvweqgvtvivmLteleelgrekcaqYwplgetltygdftvtllseeelagitlrtlevedlgdsesrtvthfhy

---QDGAPP-PDEVIDNWLRLCRETFAqHPNGFVAVHCVAGLGRAPVLVALSLI------EAGMSSEDAVLFIREKRHGAI-NRRQLQFLQDY
    |. .|   . . ..|...|| .. .|.| |.|||.||.||. ...|. |.      | |.. |.|| ..||.|.||. .  |..|| |.
tgWpdhgvppspdllldfleavreale.dpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflyda
0049772 (Phosphotyrosine protein) phosphatases II 14-153 1.5e-25 86.0 In-house 84-273 (314) alignment 
Range on Protein: 14-153
Range on HMM: 84-273/314.0
MRFLITDRPSDATVEDY----------VRVL--------------------------------------------QQENVVALCrvcEPSYDVSKLKDNG
..|..|  |.. ||.|.           |.                                               ...  |.   |  || ......|
lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivmsrdevladelsrLdaAlgKtpllildgngneptaadlellk...eelydpelferlg

IEVHDWAFQDGAPPPDEVIDNWLRLCRETfaqHPNGFVAVHCVAGLGRAP--VLVALSLIEAGMSSEDAVLFIREKRHGAINRRQLQFLQDYKRRG
|..... . || .|..| .| .|....|    ...| |.||| || ||..  |..|. ..  |.| |.|. ..|.||.  .|......|..|  . 
ikylripvpDgsaplledfdeflefieea...dkggpvlvHCkaGkgRtgtfvvaaylmkllgvsleealedvrlkRpinpnpgfieqleqyefil
0051082 (Phosphotyrosine protein) phosphatases II 16-147 1.9e-25 84.6 In-house 15-145 (151) alignment 
Range on Protein: 16-147
Range on HMM: 15-145/151.0
FLITDRPSDatveDYVRVLQQENVVALCRVCEPS---YDVSKLKDNGIEVHDWAFQDGAPPPDEVIDNWLRLCRETFAQHPNGFVAVHCVAGLGRAPVLV
..... |..    |... |..... . . ....    |. . |...||||... . |  .|. ... ....   | .....|| |.||| ||.||  .||
lyrsggpla....dflellkelgiktivnlrseeergycpeylpelgievlhipildwpdpglplsfdavleflellldkkngpvlvHCsaGkgRTGtlv

ALSLIEAGMSSEDAVLFIREKRHGAINRRQLQFLQ
|| |.  |.| |.|. ..|.||.|...  | ...|
alylmllgvsleealeeyrlkrpgvvqpnqqflfq
0047943 (Phosphotyrosine protein) phosphatases II 8-146 2.1e-24 81.8 In-house 71-264 (273) alignment 
Range on Protein: 8-146
Range on HMM: 71-264/273.0
KISHKNMRFLITDRPSDATVEDYVRVLQQENVVALCRVCEPSYD----------------VSKLKDNG--------------------------------
.  .....|..|. | . ||||. | . ..||  . ...|. ..                . . ..                                  
dgynlkrkfiatqgPlpntvedfwrmvweqnvrviVmLtelvelgrekcaqYwpleggelsltygkftvtllseetkddytvrtleltnlgtgesrtvth

IEVHDWAfQDGAPPPDEVIDNWLRLCRETFAQH-PNGFVAVHCVAGLGRAPVLVALSLI------EAGMSSEDAVLFIREKRHGAI-NRRQLQFL
. ...|   .|.||  | . ....|.|.....   || |.|||.||.||. ...|| |.      | |.. ..|| ..|..|.|.. .  |..||
fhytgwp.dhgvppslesllefielvrkalealpsngpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrfl
0050432 (Phosphotyrosine protein) phosphatases II 11-143 3.3e-24 81.2 In-house 105-288 (308) alignment 
Range on Protein: 11-143
Range on HMM: 105-288/308.0
HKNMRFLITDRPSDATVEDYVRVLQQENVVALCRVCEPSYD--------------VSKLKDNGIEV----------------------------------
.....|..|  | . ||||. | . ..||    ..... ..               . |. ... |                                  
klprkfIatqgPlpntvedFwrmvweqnvrvIvmLtklvengrekcaqYwplelgggsleygkftvtllseevlddytvrtleltnlgdgesrtvthfhy

HDWAfQDGAPPPDEVIDNWLRLCRETFaqhPNGFVAVHCVAGLGRAPVLVALSLI------EAGMSSEDAVLFIREKRHGAINRR-QL
..|   .|.||  | . ..|.|.|...   |.| ..||| ||.||. ...|| |.      | |.. ..|| ..||.|.|...   |.
tnWp.dhgvPpspeilldflelvrksl...pggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtpeqy
0051299 (Phosphotyrosine protein) phosphatases II 8-141 8.9e-24 79.9 In-house 86-272 (288) alignment 
Range on Protein: 8-141
Range on HMM: 86-272/288.0
KISHKNMRFLITDRPSDATVEDYVRVLQQENVVALCRVCEPS-------------------------------------------------YDVSKLKDN
.. .....|..|  | . ||||. | . ..||    .....                                                  .|  ... .
dgynlkrkfIatqgPlpntvedFWrmvweqnvrvIvmltklvelgrekcaqYwplggsltygditvtllseevlddytvrtlevtnldlldgdgesrtvt

GIEVHDWAfQDGAPPPDEVIDNWLRLCRETFAqHPNGFVAVHCVAGLGRAPVLVALSLI------EAGMSSEDAVLFIREKRHGAINRR
 . ...|   .|.|.  | . ..|||.|. .| ...| |.||| ||.||. ...|| |.      | |.. ..|| ..||.|.|...  
hfhytnwp.dhgvpdspellldflrlvrkala.sgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtp
PTEN_1 26-153 1e-23 79.2 In-house 55-192 (196) alignment 
Range on Protein: 26-153
Range on HMM: 55-192/196.0
TVEDYVRVLQQENVVALCRVCE------PSYDVSKLKDNGIEVHDWAFQDGAPPPDEVIDNWLRLCRETFAQHP-NGFVAVHCVAGLGRAPVLVALSLIE
 |..... |..... ......|      .||| .. ...|.|...  ..|  .|. . .  ... . |   ..| ...|.||| |||||  ..||  |..
dvaadldnlkedgitlvvnlseeeelsgrsydleeffksgveylhfpieDhgapslselfdicksfiewllsdpngnvVlVHCkaGlgRsGtvvaayLmy

AG-MSSEDAVLFIREKR-HGAIN-RRQLQFLQDYKRRG
.| .. ..|. ..|||| .||.| . | ..|. .... 
kgkltadeAlelvrekRppgapnspsqerlleyfaell
0046845 (Phosphotyrosine protein) phosphatases II 10-141 1.3e-22 76.0 In-house 73-260 (284) alignment 
Range on Protein: 10-141
Range on HMM: 73-260/284.0
SHKNMRFLITDRPSDATVEDYVRVLQQENVVALCRVCEPSY-----------------------------------------------DVSKLKDNGIEV
......|..|  | . ||||. |.. ..||  .  ..|.                                                 .   .. . . .
tyikkkfIatqgPlpntvedFwrmvweqnvrvIVmltelvengrekcaqYwplegevltygdftvtllseevkddytvrtleltnlgytgesrtvthfhy

HDWAfQDGAPPPDEVIDNWLRLCRETFAQ-HPNGFVAVHCVAGLGRAPVLVALSLIEA---------GMSSEDAVLFIREKRHGAINRR
..|   .|.||  | . ..|||.|| . . ...| ..||| ||.||. ...|| |.           |.. ..|| ..||.|.|...  
tswp.dhgvppspedlleflrlvrellenlpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtl
0048179 (Phosphotyrosine protein) phosphatases II 31-150 1.9e-22 75.0 In-house 22-141 (144) alignment 
Range on Protein: 31-150
Range on HMM: 22-141/144.0
VRVLQQENVVALCRVCEPsYDVSKLKDNGIEVHDWAFQDGAPPPD-EVIDNWLRLCRETFAqhPNGFVAVHCVAGLGRAPVLVALSLI-EAGMSSEDAVL
.  |.. .. ......|. |.   |...||... . . |  .|.. | ....|....|  .  ..| |.||| ||.||...|||. |. . |.| |.|. 
lellkklgittvinltee.yepefleregiqylhlpwpDhgvpdllellleflefieeale..eggpvlVHCsaGvgRtgtlvaaylmkklglsleeala

FIREKRHGAI-NRRQLQFLQDYK
..|..| ||. |. ||.||..| 
lvrsrrpgavpnpgqlrfLleye
subfamily_CDC14_pd Subfamily CDC14 24-149 3.7e-22 73.6 In-house 198-319 (328) alignment 
Range on Protein: 24-149
Range on HMM: 198-319/328.0
DATVEDYVRVLQQENVVALCRVCEPSYDVSKLKDNGIEVHDWAFQDGAPPPDEVIDNWLRLCRETfaqhpNGFVAVHCVAGLGRAPVLVALSLIE-AGMS
  . | ...  ...|| .. |. .  || .| .|.|.. .|  | ||. |.|... ..|... ..     .| .|||| |||||.  |.|  |..  ...
lhaPeklleyfrknnvttvvrLnkklYdakkftdaGfdhkDlffiDGstPsdaivkkfleiaeka.....eGaiavhCkaGLGrtGtLiacylmkhyrft

SEDAVLFIREKRHGAINRRQLQFLQDY
...|. ..|  | | .   | .||.. 
aaeaiawlricrPGsvigpqqkfleek
0048076 (Phosphotyrosine protein) phosphatases II 31-151 3.2e-21 71.0 In-house 22-140 (145) alignment 
Range on Protein: 31-151
Range on HMM: 22-140/145.0
VRVLQQENVVALCRVcepSYDVSKLKDNGIEVHDWAFQDGAPPPD-EVIDNWLRLCRETFAQHpnGFVAVHCVAGLGRAPVLVALSLIEA-GMSSEDAVL
.. |.. .. .. ..   ... . |...||... . . |  .|.. | ....|....|  ...  | |.||| ||.||...|||. |.   |.| |.|. 
lellkdlgittvlnl...tselellerlgiqylylpwpDhgvpdllellleflefieealkeg..gpvlVHCsaGvgRtgtlvaaylmlllgvsleeale

FIREKRHGAI-NRRQLQFLQDYKR
..|..|.||. |  ||.||... .
lvrsqrpgavpnpgqlrflyefel
0036941 (Phosphotyrosine protein) phosphatases II 8-149 1.3e-20 69.3 In-house 72-272 (297) alignment 
Range on Protein: 8-149
Range on HMM: 72-272/297.0
KISHKNMRFLITDRPSDATVEDYVRVLQQENVVALCRVCEPSY--------------------------------------DVSKLKDNG----------
.. . ...|..|  | . ||||. | . ..||  .  ..|.                                         . .|.             
dgydlkrkfIatqgPlpntvedFWrmvweqnvtvIvmltelvelgrekcaqywpleegesltygdftvtllsvevvllddytlrtlevtdtgngesrtvt

-IEVHDWAfQDGAPPPDEVIDNWLRLCRETFAQH-PNGFVAVHCVAGLGRAPVLVALSL---------IEAGMSSEDAVLFIREKRHGAI-NRRQLQFLQ
 . ...|   .|.|.  . . ....|.|.  ..  ..| | |||.||.||. ...|. |         .| |..  .||...||.|.||. .  |..|| 
hfhytgwp.dhgvpespaslldfielvrkvlkllpsggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrfly

DY
..
ea
0051429 (Phosphotyrosine protein) phosphatases II 15-150 1.9e-19 65.8 In-house 23-221 (272) alignment 
Range on Protein: 15-150
Range on HMM: 23-221/272.0
RFLITDRPSDATVEDYVRVlQQENVVALCRVCEPS---YDVSKLKDNGIEVHDWAFQDGAPPPD------------------------------------
|.. ...|...|..|. |  ..... . . .....   ..   .   ||... . . | ..|.                                     
rlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseellldyilrellltlllsageare

----------------EVIDNWLRLCREtfaqhpNGFVAVHCVAGLGRAPVLVALSLIEAGMS--------------SEDAVLFIREKRHGAI-NRRQLQ
                | . ..|.|...      .| | ||| || .|  ..||| |. .|.|               |.||  .|..|.||. .  |..
vmhlhytdwpdhgvpqeallellellld......ggpvlvHCsaGkdRTGtvvallllllgvsletivddYlltnlyleeaveelraqrpgavqteeqyl

FLQDYK
||... 
flyeal
subfamily_PTPDC1_pd Subfamily PTPDC1 49-150 6.4e-15 50.0 In-house 72-172 (182) alignment 
Range on Protein: 49-150
Range on HMM: 72-172/182.0
SYDVSKLKDNGIEVHDWAFQDGAPPPDEVIDNWLRLCRETFAqhpNGFVAVHCVAGLGRAPVLVALSLI-EAGMSSEDAVLFIREKRHGAIN-RRQLQFL
|||  .|...|| |. ....|   .. | | .  ..   .     .| ||||| |||||. ||.|  |.    ...|.|. ..|.||  .|. | |....
sYdlealmeqgiyvynfgwkDygvasleriLdivkvvafalq...egkvavhChaGlGrtGvliacylvyakrltaekaiklvrskrpksiqtreqvelv

QDYK
....
kefa
0048567 (Phosphotyrosine protein) phosphatases II 40-147 5.4e-13 43.6 In-house 18-131 (157) alignment 
Range on Protein: 40-147
Range on HMM: 18-131/157.0
VALCRVCEPSYDVSKL-KDNGIEVHDWAFQDGaPPPDEVIDNWLRLCRETFA--QHPNGFVAVHCVAGL---GRAPVLVAL-SLIEAGMSSEDAVLFIRE
..|.|. .  |..  .  |.|.  .|. |..| |..  .. .. ..  . .   .. .. .|||| |||   ||. .|...  ..  |.. |.|. ..| 
allprlpkslynalyFsiddglvyedfffdfG.PlnlailyrFilklnkflkilelagkaiavhckaglkkrgrtatLigcYlilhlgftpeeaiaplri

KRHGAINRRQLQFLQ
 | | .  |. ..|.
vrpgsvpfrdasyll
subfamily_DSP23_pd Subfamily DSP23 37-142 2.3e-12 41.8 In-house 33-134 (148) alignment 
Range on Protein: 37-142
Range on HMM: 33-134/148.0
ENVVALCRVCEPSYDVSklkdNGIEVHDWAFQDGAPPPDEVIDNWLRLCREtfAQHPNGFVAVHCVAGLGRAPVLVALSLI-EAGMSSEDAVLFIREKRH
  .|.|   ..|  . .     .. ..    .|  ||  | .....|.  |  |.. |  |.|||. | ||.  ..|  |. | .... .|.  .|..| 
rylvslteegrphveat....pnltlvrlriddyhppaleqvvefvrvvee..aeekneavsvhcllgrgrtgtmlacylvkerklaaaeaiaevrrlrp

GAINRR-Q
|...   |
gsvetveq
subfamily_RNGTT_pd Subfamily RNGTT 40-152 1.8e-11 38.1 In-house 59-170 (189) alignment 
Range on Protein: 40-152
Range on HMM: 59-170/189.0
VALCRvCEPSYDVSKLKDNGIEVHDWAFQ-DGAPPPDEVIDNWLRLCRETFAQHPNGFVAVHCVAGLGRAPVLVALSLIEA-GMSSEDAVLFIREKRHGA
. | .  .. || ..|...||. .  . .  |. |  | .... .|..| |...|.  ..|||  |  |.  |..  |.|   .| |.||   .. |.  
idltn.tsryYdkeelekegikyvklqcagkgeaPeaeqvkefiklveeffkknpeevigvhCthGfnRtGFlivsyLvekedwsveaavalFakaRppG

INRRqlQFLQDYKRR
| .   ..|... ||
iyke..dylkellrr
subfamily_PTEN_pd Subfamily PTEN 36-134 1.6e-10 36.2 In-house 59-156 (184) alignment 
Range on Protein: 36-134
Range on HMM: 59-156/184.0
QENVVALCRVCEPSYDVSKLKDNgieVHDWAFQDGAPPPDEVIDNWLRLCRETFAQHPNGFVAVHCVAGLGRAPVLVALSLIEAGMSSE--DAVLFIREK
....  .    | .|| .|....   |. . |.|  ||| |.... ..  .. ... ..  |.||| || ||. ||..  |..... ..  .|. .  |.
kdhykiynlrserkydskkfdgr...vavypfdDhnppplelleeivediekwleedkknvvvvHCkaGkGRtGvlivayllkslllekaeealelfaea

R
|
R
PTPc_DSPc_SM00012 61-141 3.2e-10 35.5 In-house 6-93 (105) alignment 
Range on Protein: 61-141
Range on HMM: 6-93/105.0
EVHDWAFQdGAPPPDEVIDNWLRLCRETFAQHP-NGFVAVHCVAGLGRAPVLVALSLIEAGMSSE-------DAVLFIREKRHGAINRR
....|  . |.| . . | ..|| ...   ..  .. | ||| || ||. ..|||...   ...|       . |  .|..|.|.... 
hytgwpdh.gvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqte
DSPc Dual specificity phosphatase, catalytic domain 50-148 2.4e-09 32.1 Pfam-A 35-129 (133) alignment 
Range on Protein: 50-148
Range on HMM: 35-129/133.0
YDVSKLKDNGIEVHDwafqdgapPPDEVIDNWLRLCRETF--AQHPNGFVAVHCVAGLGRAPVLVALSLIE-AGMSSEDAVLFIREKRhGAINRR--QLQ
.  |. .. .| |.|          .. | ..|. . |    |.  .. |.||| ||. | . |..  |..  ..|...|. |..|.| ..|...  .|.
ikkseieylripved........etetkiskeleeavefiekaeqkgkkvlVHCqaGisRSatliiaYlmktknlslneAyefvkerr.skispnagflr

FLQD
 | .
qLle
DSPc Dual specificity phosphatase, catalytic domain 50-148 2.4e-09 32.1 In-house 35-129 (133) alignment 
Range on Protein: 50-148
Range on HMM: 35-129/133.0
YDVSKLKDNGIEVHDwafqdgapPPDEVIDNWLRLCRETF--AQHPNGFVAVHCVAGLGRAPVLVALSLIE-AGMSSEDAVLFIREKRhGAINRR--QLQ
.  |. .. .| |.|          .. | ..|. . |    |.  .. |.||| ||. | . |..  |..  ..|...|. |..|.| ..|...  .|.
ikkseieylripved........etetkiskeleeavefiekaeqkgkkvlVHCqaGisRSatliiaYlmktknlslneAyefvkerr.skispnagflr

FLQD
 | .
qLle
subfamily_PTPMT1_pd Subfamily PTPMT1 52-152 2.6e-09 31.8 In-house 66-167 (171) alignment 
Range on Protein: 52-152
Range on HMM: 66-167/171.0
VSKLKDNGIEVHDWAFQDGA-PPPDEVIDNWLRLCRETFAQhpNGFVAVHCVAGLGRAPVLVALSLI-EAGMSSEDAVLFIREKRHG-AINRRQLQFLQD
. . | .|.|    | .| .  |  | . . ... ...  .     | ||| || ||.  |||  |. .  .|.|.|. ....||.   ....|.. || 
teewkklgveqlqlatvDfteapdleklekgvefiekvask..gkrvYvHCkaGrgRsatlvacylmkkeklspeeAlkalkkkRkiirlakkqwkalqe

YKRR
|.. 
yeek
PTPc_motif_SM00404 43-146 2.8e-09 32.0 In-house 35-131 (140) alignment 
Range on Protein: 43-146
Range on HMM: 35-131/140.0
CRVCEPSYDVSKLKDNGIEVHDwafqDGAPPPDEVIDNWLRLCRETfaQHPNGFVAVHCVAGLGRAPVLVALSLIE-AGMSSEDAVLFIREKRhgAINRR
 .... ..  |. .   |...|    ..  .  . .|. |.  ..   .  .| | ||| ||. |   |..  |..  ..| ..|. |..|.|   | ..
teevsltkensgfqilqipldd....nekdklskyldkvldfiena..ekkggkvlVHCqaGvSRSatliiaYlmryrqlslaeayefvkerR..piisp

QLQFL
.|.|.
nlnfv
Y_phosphatase Protein-tyrosine phosphatase 60-146 1e-08 30.3 Pfam-A 138-229 (235) alignment 
Range on Protein: 60-146
Range on HMM: 138-229/235.0
IEVHDWAfQDGAPppdEVIDNWLRLCRETFAQH--PNGFVAVHCVAGLGRAPVLVALSLIEAGMSS------EDAVLFIREKRHGAINR-RQLQFL
. ...|  . |.|   |  .. |.|.|.   ..   .| | ||| || ||. ..|||...   ...       ..|  .|..|.|....  |..||
lhytnWp.dhgvp...espkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleqleaeeevdvlqivkelRkqRpgmvqsleqYifl
Y_phosphatase Protein-tyrosine phosphatase 60-146 1e-08 30.3 In-house 138-229 (235) alignment 
Range on Protein: 60-146
Range on HMM: 138-229/235.0
IEVHDWAfQDGAPppdEVIDNWLRLCRETFAQH--PNGFVAVHCVAGLGRAPVLVALSLIEAGMSS------EDAVLFIREKRHGAINR-RQLQFL
. ...|  . |.|   |  .. |.|.|.   ..   .| | ||| || ||. ..|||...   ...       ..|  .|..|.|....  |..||
lhytnWp.dhgvp...espkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleqleaeeevdvlqivkelRkqRpgmvqsleqYifl
subfamily_DSP3_pd Subfamily DSP3 84-152 3.9e-08 27.1 In-house 88-156 (162) alignment 
Range on Protein: 84-152
Range on HMM: 88-156/162.0
LCRETFAQhPNGFVAVHCVAGLGRAPVLV-ALSLIEAGMSSEDAVLFIREKRHGAINRRQLQFLQDYKRR
  .|. .| ..| | ||||.|. |...|| |  .|   |.  .|.  .|.||.   |.  |. |......
fidealsq.kegkvlvhcvvGvsRsatlvlayLmirrkmtlveairtvrkkReilPneGFlkqLaeldee
subfamily_CDKN3_pd Subfamily CDKN3 38-152 6.1e-08 26.5 In-house 73-194 (202) alignment 
Range on Protein: 38-152
Range on HMM: 73-194/202.0
NVVALCRVCEP-SYDVSKL----KDNGIEVHDWAFQDGAPPPdevIDNWLRLCRETFAQHPNG-FVAVHCVAGLGRAPVLVALS--LIEAGMSSEDAVLF
.|  ||   |   | | .|    .  |. || . . ||  |    | . |..  |      ..    |||  ||||. ...|    ...  .. .||.  
dvfvlctrgelskyrvrrlldlyqqaglivhhypiadglvpd...iasclkileelrinlkayrktlvhcygglgrsslviaclllylddtiepkdaidk

IREKR-HGAINR-RQLQFLQDYKRR
.|. .  .||.  .| ..|.... .
lrdlkgsraiqtvkqynylsefrdk
subfamily_DSP11_pd Subfamily DSP11 46-149 8.3e-08 26.3 In-house 66-170 (178) alignment 
Range on Protein: 46-149
Range on HMM: 66-170/178.0
CEPSYDVSKLKDNGIEVHDWAFQDGAPPPDEVIDNWLRLCRETF--AQHPNGFVAVHCVAGLGRAPVLVALSLIE-AGMSSEDAVLFIREKRHGAINRRQ
 .  |. ..|.|.|.. .         | .|..... .  .|     .. . ...|||  |. |.  |.   ||.  |...|||.    | |  ...| .
tdryykkkeltdegvkylklncpGhevpkeelvkkfkeavkefleknkdndkligvhCthGvnrtGyliCrylidvegyepedaieafeearGhsleren

lqFLQDY
  .|.| 
..ylkdL
subfamily_DSP8_pd Subfamily DSP8 90-146 9.1e-07 22.6 In-house 89-144 (159) alignment 
Range on Protein: 90-146
Range on HMM: 89-144/159.0
AQHPNGFVAVHCVAGLGRAP-VLVALSLIEAGMSSEDAVLFIREKRhGAINrRQLQFL
|.. || | ||. ||  |.. | .|  . .  ||...|  |..|||  .|. ..|.||
aksengrvlvhvlaGisrsatvaiayimktlemsldeayrfvkekr.ptis.pnlnfl
subfamily_DSP10_pd Subfamily DSP10 14-135 1.3e-06 22.4 In-house 18-134 (159) alignment 
Range on Protein: 14-135
Range on HMM: 18-134/159.0
MRFLITDRPSDATVEDYVRVLQQENVVALCRVCEPSYDVSKLKDNGIEVHDWAFQDGAPPPDEVIDnwlrLCREtfAQHPNGFVAVHCVAGLGRA-PVLV
. ||.     ||. .| .. |. . |. .   .   .. ..|| . |.|.|   |.     .| ..       |  |.. .  | ||| ||. |.  | .
lpfLflGsekdaadldaldrlnitavlnvttsvPnefeeealkYkripvsDtskqnlkqyfeeale....fiee..arkkgsrvLvhCqaGisrsatvvi

ALSLIEAGMSSEDAVLFIREKRH
|  . . ..| .||  |..||| 
aYlmkhlnlslndaykfvkekrp
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 11-119 3.8e-06 20.6 In-house 85-194 (392) alignment 
Range on Protein: 11-119
Range on HMM: 85-194/392.0
HKNMRFLITDRPSDATVEDYVRVLQQENVVALCRVCEPSyDVSKlKDNGIEVHDWAFQDGaPPPD--EVIDNWLRLCRETFAQHPNGF--VAVHCVAGLG
. .  .. .. |  |...|. |.. |||| ... | .   .  |  |.   |  . | .  |  |  .   . |.. .|  |.. .    . .|| ||.|
dnekayiasqgpnaaslddfwrmvfqenvttiamvtklk.egdk.gddartvaqfhftew.PdkdvpkhtssllkfikevkadfGqythpliihcsagvg

RAPVLVALSLIEA
|. |....  . |
rtgvvisidsvva
subfamily_Tensin_pd Subfamily Tensin 32-114 4.3e-06 19.3 In-house 43-124 (189) alignment 
Range on Protein: 32-114
Range on HMM: 43-124/189.0
RVLQQ--ENVVALCRVCEPSYDVSKLKDngiEVHDWAFQDGAPPPDEVIDNWLRLCRETFAQHPNGFVAVHCVAGLGRAPVLVAL
..|..  .. . .  . | .||.|||..   .| |  . |   |. | .    .   . . ..|.  |.|||  | ||  |.|. 
kllkskhndkylvfnlsekrydisklnk...kvldfGWPdllaPsleklcsicksldsWlkadpqnvvvvhckGgkgrigvvvsa
subfamily_PTPRB_pd Subfamily PTPRB 69-127 5.9e-06 20.5 In-house 192-251 (293) alignment 
Range on Protein: 69-127
Range on HMM: 192-251/293.0
DGAPPPDEVIDNWLRLCRETF-AQHPNGFVAVHCVAGLGRAPVLVALSLIEAGMSSEDAV
 | |   . . ...|  ||.   .. .. . ||| ||.||. ...||  .   ...|| |
hgvPektktlldfvrtvreaiektaskrPivvhCsaGvGRtGtfialdrllqaieeedyv
subfamily_DSP15_pd Subfamily DSP15 94-149 6.1e-06 20.4 In-house 78-135 (151) alignment 
Range on Protein: 94-149
Range on HMM: 78-135/151.0
NGFVAVHCVAGLGRAPVLVALSLIEA-GMSSEDAVLFIREKRHGAI-NRRQLQFLQDY
.. | |||.||. |.  ||.. |. .  .. .||. .|...|  |  |    . |..|
eenvlvhClaGvsRsvtlvvaYlmtvtelnwrdalevikaaRsvanPnfGfkrqlkey
subfamily_PTPN13_pd Subfamily PTPN13 91-150 6.8e-06 20.6 In-house 199-263 (273) alignment 
Range on Protein: 91-150
Range on HMM: 199-263/273.0
QHPNGFVAVHCVAGLGRAPVLVALSLI----E--AGMSSEDAVLFIREKRHGAINRRQlQFLQDYK
|. .| ..||| ||.||. .|...  .    |    .  .. |  .||.|.| .  .. |..  ||
qtdagPivvhcsaGiGrsGtlitidvvlglierdkefdvkeivrklreqrqgvvqtkd.qyifvyk
subfamily_VSP_pd Subfamily VSP 38-136 8.5e-06 19.8 In-house 77-172 (212) alignment 
Range on Protein: 38-136
Range on HMM: 77-172/212.0
NVVALCrvCEPSYDVSKLKDNgieVHDWAFQDGAPPPDEVIDNWLRLCRETFAQHPNGFVAVHCVAGLGRAPVLVALSLIEAGMS--SEDAVLFIREKRH
.|| ||   | .|| . ....   |.    .|   |  | . .  .  .| ... ..  .|.||  | ||.  .|   |.....   ..... .. |.| 
kvvnlc..seraydekyfnnr...vkriliddhnvpkleellvftkevkewlekdlknvlaihckGGkgrtGtivcalllaseifetakesldyfgerrt

G
 
d