Gene SSH-1 in Monosiga brevicollis

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family DSP
Subfamily Slingshot
Protein sequence
ID Type Fasta BLAST phosphatome Note
MbreP019_AA protein Get Run
MbreP019_AA_406-550 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_Slingshot_pd Subfamily Slingshot 391-551 2e-86 281.6 In-house 1-161 (169) alignment 
Range on Protein: 391-551
Range on HMM: 1-161/169.0
YRKIIDQQMITVMGQMEPSSKIFDYLYLGTEWNASNWEELSRNNCQYIINVTCEIENFFPDKIKYCNIRVWDVPTTTIWPNWNRTYDFIRQARKAGSSVL
|...||..|....||.. .|||||..|||.||||||.|||..|...||.|||.||.||||.|..|.||||.| ..|.....||.||.||..|.|.||.||
ykefidnemlvilgqldsaskifdhvylGsewnasnleelkengveyilnvtkeidnffpekfeylnirvydeeetdllkywnetykfiekakkkgskvl

VHCKMGVSRSASTVIAYAMKQYSWSLEEAHAFVKKRRRIIKPNEGFRTQLVMYEGMLTARR
||||||||||||||||||||.|..|||||...||.||..||||.|| .|| .|||.|.|..
vhckmGvsrsastviayamkeyglsleealeyvkerrsvikPnkgflkqleeyeGileask
subfamily_DSP1_pd Subfamily DSP1 405-548 2.3e-44 145.4 In-house 14-157 (163) alignment 
Range on Protein: 405-548
Range on HMM: 14-157/163.0
QMEPSSKIFDYLYLGTEWNASNWEELSRNNCQYIINVTCEIENFFPDKIKYCNIRVWDVPTTTIWPNWNRTYDFIRQARKAGSSVLVHCKMGVSRSASTV
  .|. || |.||||.| .||| | |....   |.||. |..|.|.|  .| .. . | |.  |   ...  .|| ...|..  ||.||..|.|||.. .
lydPvekildfLylGsetvasnleiLkslgitailnvskeldnvfedlfeYkklkleDspkadislvfeeviefidevkkknGkvlihCqaGisRsstlc

IAYAMKQYSWSLEEAHAFVKKRRRIIKPNEGFRTQLVMYEGMLT
.|| ||.  .|||||. |||.|| ||.|| ||  ||. ||  |.
laylmktkrvsleeafdfvkqrRsiisPnagFvlqLlnyekkll
subfamily_DSP10_pd Subfamily DSP10 406-550 1.2e-42 139.5 In-house 11-156 (159) alignment 
Range on Protein: 406-550
Range on HMM: 11-156/159.0
MEPSSKIFDYLYLGTEWNASNWEELSRNNCQYIINVTCEIENFFPD-KIKYCNIRVWDVPTTTIWPNWNRTYDFIRQARKAGSSVLVHCKMGVSRSASTV
  | |... .|.|| | .|.. . | | | ....|||... |.| . ..||  | | |  .  .  ...  ..|| .||| ||.|||||. |.||||. |
tapasqvlpfLflGsekdaadldaldrlnitavlnvttsvPnefeeealkYkripvsDtskqnlkqyfeealefieearkkgsrvLvhCqaGisrsatvv

IAYAMKQYSWSLEEAHAFVKKRRRIIKPNEGFRTQLVMYEGMLTAR
||| ||. . ||..|. |||..| || || .|  ||. .|  |.  
iaYlmkhlnlslndaykfvkekrpiisPnLnfmGqLlefekelnks
0044763 (Phosphotyrosine protein) phosphatases II 391-549 1.4e-42 140.7 In-house 5-172 (178) alignment 
Range on Protein: 391-549
Range on HMM: 5-172/178.0
YRKIIDQQMITVMGQMEPSSKIFDYLYLGTEWNASNWEELSRNNCQYIINVTCEIENFFPDK---------IKYCNIRVWDVPTTTIWPNWNRTYDFIRQ
.| ...  . . .... . |.|...||||. ..|...| | ......|.|.| |.|..|..          |.|..| . | .....   . ....||..
trvllsnleglersdyinaseilpglylgslppaddlellkelgithivnlteelelgflkcdpywpeeagiqylhipipDhgvpdllehflefvefiee

AR-KAGSSVLVHCKMGVSRSASTVIAYAMKQYSWSLEEAHAFVKKRRRiIKPNEGFRTQLVMYEGMLTA
|. . |. |||||..||.||.. |.|| ||....||||| ..|..||. | ||.|.. || ..| .| .
aldekggpvlVHCsaGvgRsgtlvaaylmkklglsleeaielvrerRp.ivpnpgqlrqLyefelrllk
subfamily_DSP19_pd Subfamily DSP19 410-546 7.3e-40 130.8 In-house 13-149 (152) alignment 
Range on Protein: 410-546
Range on HMM: 13-149/152.0
SKIFDYLYLGTEWNASNWEELSRNNCQYIINVTCEIENFFPDKIKYCNIRVWDVPTTTIWPNWNRTYDFIRQARKAGSSVLVHCKMGVSRSASTVIAYAM
... ..||||    |.. |.|....  .|.||. ...|.||....|..| ..|.| |..   .... |||..||..   |||||. ||||||| |||| |
geveprlylgsqdvaadkeilkekkitHilnvatgvpnvfpkdftylsieilDlpetdllsylkealdFieearskdgavlvHCnAGvSRsasvviaylm

KQYSWSLEEAHAFVKKRRRIIKPNEGFRTQLVMYEGM
|. . |||||   |.. |. |||||||  ||  ||  
kkeelsleealelvrearpcikPneGFikqLkeyeae
subfamily_DSP14_pd Subfamily DSP14 407-550 5.8e-39 127.6 In-house 5-147 (157) alignment 
Range on Protein: 407-550
Range on HMM: 5-147/157.0
EPSSKIFDYLYLGtEWNASNWEELSRNNCQYIINVTCEIENFFPDKIKYCNIRVWDVPTTTIWPNWNRTYDFIRQARKAGSSVLVHCKMGVSRSASTVIA
.  |.| ..|.|.    |.. |.|....   ||||| |. |   ..|.. ...| | |.... . .....| |....|.|  .||||..||||||| ..|
aalsqitpsLfls.gvaalskellkkkkitliinvtvelpntklkdiervkvpveDnpeaklakhfdevadkieevkkkggktlvhCvaGvSRSAslcla

YAMKQYSWSLEEAHAFVKKRRRIIKPNEGFRTQLVMYEGMLTAR
| ||  . ||.||.  ||..| ||.|| ||  ||. ||  |...
ylmkyeklsLreayklvksaRpiirPNvGFwkqlidyEkklkgk
0048076 (Phosphotyrosine protein) phosphatases II 410-547 1.6e-36 120.5 In-house 5-142 (145) alignment 
Range on Protein: 410-547
Range on HMM: 5-142/145.0
SKIFDYLYLGTEWNASNWEELSRNNCQYIINVTCEIENFFPDKIKYCNIRVWDVPTTTIWPNWNRTYDFIRQARKAGSSVLVHCKMGVSRSASTVIAYAM
|.|...||||  ..|...|.| ...  ...|.|.|.|....  |.|... ..| .. ...  . . ..||..|.|.|  |||||..||.|... |.|| |
seilpglylgslptaldlellkdlgittvlnltselellerlgiqylylpwpDhgvpdllellleflefieealkeggpvlVHCsaGvgRtgtlvaaylm

KQYSWSLEEAHAFVKKRRRIIKPNEGFRTQLVMYEGML
.....||||| ..|...|... ||.|.. .| ..| .|
lllgvsleealelvrsqrpgavpnpgqlrflyefelel
PTPc_motif_SM00404 410-544 2.9e-36 119.4 In-house 3-138 (140) alignment 
Range on Protein: 410-544
Range on HMM: 3-138/140.0
SKIFDYLYLGTEWNASNWEELSRNNCQYIINVTCEIENF-FPDKIKYCNIRVWDVPTTTIWPNWNRTYDFIRQARKAGSSVLVHCKMGVSRSASTVIAYA
|.| ..||||.. .|.| . |. .. ...|||| |...     ......| . |  .. . . .....|||..|.| | .|||||..||||||. .||| 
srilphlylgskskaqnpallkklgithvinvteevsltkensgfqilqiplddnekdklskyldkvldfienaekkggkvlVHCqaGvSRSatliiaYl

MKQYSWSLEEAHAFVKKRRRIIKPNEGFRTQLVMYE
|.....||.||  |||.|| ||.||..|  ||. ||
mryrqlslaeayefvkerRpiispnlnfvrqLieye
subfamily_DSP6_pd Subfamily DSP6 409-549 3.9e-36 118.0 In-house 14-156 (158) alignment 
Range on Protein: 409-549
Range on HMM: 14-156/158.0
SSKIFDYLYLGTEWNASNWEELSRNNCQYIINVTCEIENFFPD--KIKYCNIRVWDVPTTTIWPNWNRTYDFIRQARKAGSSVLVHCKMGVSRSASTVIA
  .| ..||||.. .||| | |.. . .|..||| ...|.| .  ..|| .| . |. .. .   .  . .|| .||.. |.|||||  |.|||   ..|
pveilpllylGsakdasnlevlkklkikyvlnvtsnlpnkfeesgelkylqipiedhlsqnlakffPeaiefidearskkskvlvhClaGisrsvtvtla

YAMKQYSWSLEEAHAFVKKRRRIIKPNEGFRTQLVMYEGMLTA
| ||..  ||..|...||||.  | ||  |  ||. .| .|. 
ylmkklalslndaydlvkkrksnisPnfnfmgqlldferslrl
0048179 (Phosphotyrosine protein) phosphatases II 410-547 1e-34 114.6 In-house 5-144 (144) alignment 
Range on Protein: 410-547
Range on HMM: 5-144/144.0
SKIFDYLYLGTEWNASNWEELSRNNCQYIINVTCEIENFFPDKI--KYCNIRVWDVPTTTIWPNWNRTYDFIRQARKAGSSVLVHCKMGVSRSASTVIAY
|.|...||||  . |...|.| ...  ..||.| | |. |. .   .|... . | .. ...  ......||..|.. |  |||||..||.|... |.||
seilpglylgslptaldlellkklgittvinlteeyepefleregiqylhlpwpDhgvpdllellleflefieealeeggpvlVHCsaGvgRtgtlvaay

AMKQYSWSLEEAHAFVKKRRRIIKPNEGFRTQLVMYEGML
 || . .||||| |.|..|| .. ||.|.. .| .|| .|
lmkklglsleealalvrsrrpgavpnpgqlrfLleyekll
0041856 (Phosphotyrosine protein) phosphatases II 408-547 1.3e-34 114.8 In-house 18-172 (182) alignment 
Range on Protein: 408-547
Range on HMM: 18-172/182.0
PSSKIFDYLYLGTEWN--------------ASNWEELSRNNCQYIINVTCEI---ENFFPDKIKYCNIRVWDVPTTTiwpnWNRTYDFIRQARKAGSSVL
....| ..||||  ..              |.... | ......|.|.|.|    |..    |.|... . | ....    .. ..|||..... |  ||
dldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlteelywpellerlgiqylylpwpDhgvpd....ldelldfieevleeggpvl

VHCKMGVSRSASTVIAYAMKQYSWSLEEAHAFVKKRRR--IIKPNEGFRTQLVMYEGML
|||..||.|... |.|| ||....||||| ..|..||   .| || .|  ||...| .|
VHCsaGvgRtgtlvaaylmkklgvsleeavklvrsrRpgmvitpnqyfflqlallelll
subfamily_MKPLT_pd Subfamily MKPLT 405-548 1.8e-34 112.6 In-house 18-161 (164) alignment 
Range on Protein: 405-548
Range on HMM: 18-161/164.0
QMEPSSKIFDYLYLGTEWNASNWEELSRNNCQYIINVTCEIENFFPDKIKYCNIRVWDVPTTTIWPNWNRTYDFIRQARKAGSSVLVHCKMGVSRSASTV
.. ||  . | ||||   .| | . |   . ..|.||. |  . ||  ..| ...| |...... .  .|. .|. .| ..|  ||||| .|.|||.|. 
kiypsvvledtlylGnakhatnekvlkdlkithivnvsqekkdafpksveYlqvkvedesdeqlssfleraakfladaidsGGrvlvhcvqGksrsssvt

IAYAMKQYSWSLEEAHAFVKKRRRIIKPNEGFRTQLVMYEGMLT
.|. .|   | |.||. ..|.|| |..|| ||  ||  .| .. 
vafLikskgwtlkeayeylkerrsivapnrGflkqlakfeelil
subfamily_MKPLV_pd Subfamily MKPLV 405-548 1.8e-34 112.6 In-house 18-161 (164) alignment 
Range on Protein: 405-548
Range on HMM: 18-161/164.0
QMEPSSKIFDYLYLGTEWNASNWEELSRNNCQYIINVTCEIENFFPDKIKYCNIRVWDVPTTTIWPNWNRTYDFIRQARKAGSSVLVHCKMGVSRSASTV
.. ||  . | ||||   .| | . |   . ..|.||. |  . ||  ..| ...| |...... .  .|. .|. .| ..|  ||||| .|.|||.|. 
kiypsvvledtlylGnakhatnekvlkdlkithivnvsqekkdafpksveYlqvkvedesdeqlssfleraakfladaidsGGrvlvhcvqGksrsssvt

IAYAMKQYSWSLEEAHAFVKKRRRIIKPNEGFRTQLVMYEGMLT
.|. .|   | |.||. ..|.|| |..|| ||  ||  .| .. 
vafLikskgwtlkeayeylkerrsivapnrGflkqlakfeelil
subfamily_DSP12_pd Subfamily DSP12 410-548 1.9e-33 110.1 In-house 3-144 (155) alignment 
Range on Protein: 410-548
Range on HMM: 3-144/155.0
SKIFDYLYLGTEWNASNWEELSRNNCQYIINVTCE-I--ENFFPDKIKYCNIRVWDVPTTTIWPNWNRTYDFIRQARKAGSSVLVHCKMGVSRSASTVIA
|.| . ||||.  .. . | |.  . . .. |. | .  ..  . |... .| . | |.. |  . ... ||| .|.. . .|||||..|||||...|||
srilpglylggleavqeeellkelkithvlsvikeelpehklkkgkvstkfiqilDepeediLshldeavdFieealeeegavlvHCqagvSRSvtiviA

YAMKQYSWSLEEAHAFVKKRRRIIKPNEGFRTQLVMYEGMLT
| ||.. .|||.|. .||. .. |.||||| .|| ..| | .
YlmkkeklslekAlklvkekkpeiepNegFleQLklfekmgc
DSPc Dual specificity phosphatase, catalytic domain 416-544 2.6e-32 106.5 Pfam-A 1-131 (133) alignment 
Range on Protein: 416-544
Range on HMM: 1-131/133.0
LYLGTEWNASnWEELSRNNCQYIINVTCEIEN---FFPDKIKYCNIRVWDVPTTTIWPNWNRTYDFIRQARKAGSSVLVHCKMGVSRSASTVIAYAMKQY
||||.. .||  . |. .. ...|||| |..|   . . .|.| .| | |  .| | .  .....||..|.. | .|||||..|.||||. .||| ||..
lylgskstas.lalleklgitlvinvtkevpnnnaikkseieylripvedetetkiskeleeavefiekaeqkgkkvlVHCqaGisRSatliiaYlmktk

SWSLEEAHAFVKKRRRIIKPNEGFRTQLVMYE
..||.|| .|||.|| .| ||.||  ||. ||
nlslneAyefvkerrskispnagflrqLleye
DSPc Dual specificity phosphatase, catalytic domain 416-544 2.6e-32 106.5 In-house 1-131 (133) alignment 
Range on Protein: 416-544
Range on HMM: 1-131/133.0
LYLGTEWNASnWEELSRNNCQYIINVTCEIEN---FFPDKIKYCNIRVWDVPTTTIWPNWNRTYDFIRQARKAGSSVLVHCKMGVSRSASTVIAYAMKQY
||||.. .||  . |. .. ...|||| |..|   . . .|.| .| | |  .| | .  .....||..|.. | .|||||..|.||||. .||| ||..
lylgskstas.lalleklgitlvinvtkevpnnnaikkseieylripvedetetkiskeleeavefiekaeqkgkkvlVHCqaGisRSatliiaYlmktk

SWSLEEAHAFVKKRRRIIKPNEGFRTQLVMYE
..||.|| .|||.|| .| ||.||  ||. ||
nlslneAyefvkerrskispnagflrqLleye
0049772 (Phosphotyrosine protein) phosphatases II 406-549 1.5e-31 105.7 In-house 155-275 (314) alignment 
Range on Protein: 406-549
Range on HMM: 155-275/314.0
MepsskifdylylgTEWNASNWEELSrnncqyiinvtCEI--ENFFPDK-IKYCNIRVWDvPTTTIWPNWNRTYDFIRQArKAGSSVLVHCKMGVSRSAS
.              |..|...|.|             |.   ..|..  |||..| |.| ... .   ... ..||..| ..|. ||||||.|..|...
g.............neptaadlellk...........eelydpelferlgikylripvpD.gsaplledfdeflefieea.dkggpvlvHCkaGkgRtgt

-TVIAYAMKQYSWSLEEAHAFVKKRRRiIKPNEGFRTQLVMYEGMLTA
  |.|| ||.. .||||| ..|...|  |.||.||. ||  || .| |
fvvaaylmkllgvsleealedvrlkRp.inpnpgfieqleqyefilea
0043147 (Phosphotyrosine protein) phosphatases II 409-548 1.9e-31 104.5 In-house 19-161 (172) alignment 
Range on Protein: 409-548
Range on HMM: 19-161/172.0
SSKIFDYLYLGTEWNASNWEELSRNNCQYIINVTCE---IENFFPDKIKYCNIRVWDVPTTtIWPNWNRTYDFIRQ--ARKAGSSVLVHCKMGVSRSAST
  ......... .  |..|. | ......|.|.| .    |....  |.|. . . | ... .   . ....||..  |.. |  |||||..||.|..  
pdrfiatqgplrntladfwrmlkelgithivnltellydpellerlgiqylylpwpDhgvp.llellleflefidellalspggpvlVHCsaGvgRtgtl

VIAYAMKqYSWSLEEAHAFVKKRRRIIKPNEGFRTQLVMYEGMLT
|.|| |. ...||||| |.|...|... .|.... .| ..| .| 
vaaylml.lglsleeavalvrekRpgavqnpsqyrflyyfeklll
subfamily_LRR-DSP_pd Subfamily LRR-DSP 409-548 3.1e-31 102.4 In-house 120-259 (263) alignment 
Range on Protein: 409-548
Range on HMM: 120-259/263.0
SSKIFDYLYLGTEWNASNWEELSRNNCQYIINVTCEIENFFPDKIKYCNI-RVWDVPTTTIWPNWNRTYDFIRQARKAGsSVLVHCKMGVSRSASTVIAY
 ..| | |.||.   | |   |  ..  .|.   ...| .||.  ||  |  . ||.   |   ...|  || . || |  |||||. |||||.. ||.|
PdeiidklflGgldsannksilkdlgvthillavadfePlfPklfkylsiddiedvdeadisqhfeetnafieeGrkkG.GvlvhcraGvsrsstlvisy

AMKQYSWSLEEAHAFVKKRRRIIKPNEGFRTQLVMYEGMLT
 ||. .  ..||  .|.|.|  |.|| ||. ||  ||  | 
lmkkqrlkfkealdlvikkrpriqPnpGfkdqlkkyekklf
subfamily_DSP8_pd Subfamily DSP8 409-549 4.3e-30 98.4 In-house 15-156 (159) alignment 
Range on Protein: 409-549
Range on HMM: 15-156/159.0
SSKIFDYLYLGTEWNASNWEELSRNNCQYIINVT--CEIENFFPDKiKYCNIRVWDVPTTTIWPNWNRTYDFIRQARKAGSSVLVHCKMGVSRSASTVIA
  .| ..||||.. .. . | ||... .|..|.   |   ...... |.  . | |  .  . | ......|| .|... ..||||.  | ||||. .||
ptrilknlylGsqkdvlseellsklgisyvlnasnscpkleelkes.kflrvPvkDkydekllpwfdksvefidkaksengrvlvhvlaGisrsatvaia

YAMKQYSWSLEEAHAFVKKRRRIIKPNEGFRTQLVMYEGMLTA
| ||. . ||.||. |||..|  |.||  |  ||. ||  |. 
yimktlemsldeayrfvkekrptispnlnflgqLleyekelkl
0045098 (Phosphotyrosine protein) phosphatases II 406-546 9.6e-30 99.3 In-house 19-270 (278) alignment 
Range on Protein: 406-546
Range on HMM: 19-270/278.0
MEPSSKIFDYLYLGTEW-----------------------------------------NASNWEELSRNNCQYIINVT----------------------
. . |.|...||||  .                                          |..|. |  .....|...|                      
lgipseitpalylgnldknRykdilpydhsrVkdYINAsyidgypkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrekcaqywpeggslty

------------------------------CEIENFFPDKIKYCNIRVWDVPTTTIWPNWNRTYDFIRQARK--------------AGSSVLVHCKMGVS
                               ..|...   ..| ..   .||...|.  . . ..|||.|.|               |  |||||..||.
gdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsggpvlVHCsaGvg

RSASTVIAYAMKQY---SWSLEEAHAFVKKRRRI-IKPNEGFRTQLVMYEGM
|..  |.|| |...    ..|.|| ......|.. . .|...  .| ... .
RtGtlvaaylmlelleggvdlleavkelrsqRpglavqnleqyrflyeflle
subfamily_DSP15_pd Subfamily DSP15 410-545 3e-29 96.1 In-house 3-137 (151) alignment 
Range on Protein: 410-545
Range on HMM: 3-137/151.0
SKIFDYLYLGTEWNASNWEELSRNNCQYIINVTCEIENFFPDkIKYCNIRVWDVPTTTIWPNWNRTYDFIRQARKAGSSVLVHCKMGVSRSASTVIAYAM
||.   ||||   .... | |...|   |..|  . .....| |.|  |.. | | . .    . . .|| ..|  . .||||| .|||||.  |.|| |
skvlpglylgnfrdskdeelLkeknithilsvhdnakkllkd.ieYkciaasDtpsaklskffkesvefihkcRlkeenvlvhClaGvsRsvtlvvaYlm

KQYSWSLEEAHAFVKKRRRIIKPNEGFRTQLVMYEG
   . . ..|  ..|..| . .|| ||..||  || 
tvtelnwrdalevikaaRsvanPnfGfkrqlkeyek
0046846 (Phosphotyrosine protein) phosphatases II 402-547 3.4e-29 97.2 In-house 5-172 (176) alignment 
Range on Protein: 402-547
Range on HMM: 5-172/176.0
VMGQMEPSSKIFDYLYLGTEW----------NASNWEELSRNNCQYIINVTCEI-------ENFFPD----KIKYCNIRVWDVPTTTIwPNWNRTYDFIR
..|  .... | ..|.||  .           |...|.| ........|.| |.        |..|.    .|.|... . |  . ..   . . ..|||
llgldldldyinanlilgsrpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgiqylhlpwpDhgvpdl.elllellefir

QARKAGSSVLVHCKMGVSRSASTVIAYAMKQ-YSWSLEEAHAFVKKRRR-IIKPNEGFRTQLVMYEGML
.|.|.|  |||||..|..|..  |.|| ..  . .|.||| |.|...|.  . ...... .| ..| .|
ealkeggpvlVHCsaGigRtgtlvaayllelekglsveealalvreqRplgavqtpeQyrflyefelll
subfamily_Choan-DSP_MKP-1_pd Subfamily Choan-DSP_MKP-1 409-544 4e-29 95.0 In-house 8-144 (148) alignment 
Range on Protein: 409-544
Range on HMM: 8-144/148.0
SSKIFDYLYLGTEWNASNWEELSRNNCQYIINVTCEIENFFPDK-IKYCNIRVWDVPTTTIWPNWNRTYDFIRQARKAGSSVLVHCKMGVSRSASTVIAY
|     .|.||    |...| |   .   |.| | | .| . .. |.| .... | |   .   ..   .|.|.|...|  ||||..||||||.  ....
seikdafLFlGskksaadlealkalgvtrivnatkerdnaldqrgieYlhvaldDkpkedlsaiFediiafvrkakdeGrrvLvhlqmGvsrssalallw

AMKQYSWSLEEAHAFVKKRRRIIKPNEGFRTQLVMYE
 ..    ||.|| |.|| .|| ..|| ||  ||  .|
lidfkrvslkealalvkskrryvdpnlgfLkqLaele
0049260 (Phosphotyrosine protein) phosphatases II 410-547 7.7e-29 95.7 In-house 9-149 (152) alignment 
Range on Protein: 410-547
Range on HMM: 9-149/152.0
SKIFDYLYLGTEWNASNWEELSRNNCQYIINVTCEIEN---FFPDKIKYCNIRVWDVPTTTIWPNWNRTYDFIRQ-ARKAGSSVLVHCKMGVSRSASTVI
 ..  ....| .. |..|. | ......|...| . |.   ...  |.|... . | .. ..       ..||.. |.. |  |||||. ||.|..  |.
fefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyiqylhlpwpDhgvpdlsqlllflllfieklaldkggpvlVHCsaGvgRtgtlva

AYAMKqYSWSLEEAHAFVKKRRRIIKPNEGFRTQLVMYEGML
|| |. . .||||| |.|...| .. ||.|.. .|  .|..|
aylml.lgvsleeavalvrekRpgavpnpgqlrflyefekll
subfamily_Dicty-DSP19-like_pd Subfamily Dicty-DSP19-like 410-545 1.3e-27 90.0 In-house 4-150 (154) alignment 
Range on Protein: 410-545
Range on HMM: 4-150/154.0
SKIFDYLYLGTEWNASNWEELSRNNCQYIINVTCEIENFFPDK---------IKYCNIRVWDVPTTTIWPNWNRTYDFIRQAR--KAGSSVLVHCKMGVS
||   .||...   | |  .|  .| . |.||   |.| |.|.         |.|.|....| .   |  . .....||..|      . ||||.. |||
skeaiflyissfdaalnkldlqlkniksilnvgiGinnlftdensdindgfiieylnlelfddvnfdiiekldkafefiddaiggvennkvlvhsdkGvs

RSASTVIAYAMKQYSWSLEEAHAFVKKRRRIIKPNEGFRTQLVMYEG
|||. .|.| |.. . || .|  ..|. | |||||.||  || ..| 
rsaallisylmdklkislslalellkdsryiikPnqGflkqleifek
0040439 (Phosphotyrosine protein) phosphatases II 422-545 8.2e-26 86.5 In-house 66-243 (249) alignment 
Range on Protein: 422-545
Range on HMM: 66-243/249.0
WNASNWEELSRNNCQYIINVTCEIEN-------------------------------------------FFPDKIKYCNIRVWDVPTTTIWPNWNRTYDF
  ...|. | ......|...| . |.                                            .......  |.. | | . . |. . . ||
tvedfwrmlwelgitvivmLtslvelgrekcaqywplggsleygdftvtllsvevkddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldf

IRQARK------AGSSVLVHCKMGVSRSASTVIAYAM-----KQYSWSLEEAHAFVKKRRRIIKPNEGFRTQLVMYEG
|...||       |. |||||..||.|..  ..|| |     | . ..|||| ......|. . .|...  .| ... 
ieavrkaleelpkggpvlVHCsaGvgRtGtfiaaylmleqlekelgvdleeavkllrsqRpgavqnpeqyrflyeall
subfamily_DSP3_pd Subfamily DSP3 409-548 1.2e-25 84.1 In-house 11-158 (162) alignment 
Range on Protein: 409-548
Range on HMM: 11-158/162.0
SSKIFDYLYLGTEWNASNWEELSRNNCQYIINVTCE----I---ENFFP-DKIKYCNIRVWDVPTTTIWPNWNRTYDFIRQARKA-GSSVLVHCKMGVSR
   ... ||.| |  |.. ..| .    ...| .      .   ..|.   .|||. . | |||.. .   .... .||..| .   . |||||..||||
vdevypklyvgdeavakdkskLkklGithvlnaaegrfskvdtgaefykdleikylGlevdDvpefdlskyFetaakfidealsqkegkvlvhcvvGvsR

SASTVIAYAMKQYSWSLEEAHAFVKKRRRiIKPNEGFRTQLVMYEGMLT
||  |.|| | . . .| ||   |.|.|. | |||||  ||. ..  |.
satlvlayLmirrkmtlveairtvrkkRe.ilPneGFlkqLaeldeelk
0045450 (Phosphotyrosine protein) phosphatases II 415-544 1.3e-25 86.3 In-house 97-300 (307) alignment 
Range on Protein: 415-544
Range on HMM: 97-300/307.0
YLYLGTEWNASN---------------WEELSRNNCQYIINVTCEIEN-------FFPDK---------------------IKYCNIRVWDV--------
.|.|.. ..  .               |. | ......|...| ..|.       ..||.                     ... ...|.|         
lllldgydlkrkfIatqgPlpetvedFwrmlweqgvtvivmltelvelgrekcaqywPdegeeltygnftvtllseehldgytvrtlevtdldgtgesrt

---------PTTTIWPNWNRTYDFIRQARK------AGSSVLVHCKMGVSRSASTVIAYAMKQYS--------WSLEEAHAFVKKRRRIIKPNEGFRTQL
         | ... |... . |||...||       |. |||||..||.|... ..|| |...         ..|.|| ......|  . .|...  .|
vthfhytgwpdhgvppsfeelldfieevrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrfl

VMYE
 ...
yeal
0051082 (Phosphotyrosine protein) phosphatases II 410-543 7.3e-25 82.7 In-house 9-149 (151) alignment 
Range on Protein: 410-543
Range on HMM: 9-149/151.0
SKIFDYLYLGTEWNASNWEELSRNNCQYIINVTCEI-----ENFFPD-KIKYCNIRVWDVPTTTIWPNWNRTYDFIRQARKA-GSSVLVHCKMGVSRSAS
| . ..||..    | ..|.| ......|.|.. |       ...|.  |....| ..| |....  ...   .|......  .  |||||..|..|.. 
syvtgglyrsggpladflellkelgiktivnlrseeergycpeylpelgievlhipildwpdpglplsfdavleflellldkkngpvlvHCsaGkgRTGt

TVIAYAMKqYSWSLEEAHAFVKKRRR-IIKPNEGFRTQLVMY
 |..| |. . .||||| ......|  .. ||..|. || ..
lvalylml.lgvsleealeeyrlkrpgvvqpnqqflfqlfal
0037934 (Phosphotyrosine protein) phosphatases II 411-544 1.1e-24 82.7 In-house 41-238 (243) alignment 
Range on Protein: 411-544
Range on HMM: 41-238/243.0
KIFDYLYLGTE--------WNASNWEELSRNNCQYIINVTCEI---------------------------------------------ENFFPDKIKYCN
.....|...          . ||.|. | ......|...| ..                                             ....   |.|. 
yvtprliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywpgevtygdftvtllseehlddytvrtlllenldlddltrlvihyhy

IRVWD----VPTTTIWPNWNRTYDFIRQ-----ARKAGSSVLVHCKMGVSRSASTVIAYAMKQY-SWSLEEAHAFVKKRRRI-IKPNEGFRTQLVMYE
. . |      .. ..  .. ...||..     |.. |. |||||..||.|..  ..|| |... ...|||| ......|   . ...... .| ...
lpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRtGtliaaylmllllgvdleeavkllreqRpgkavqtpsqyrflyeal
0036282 (Phosphotyrosine protein) phosphatases II 410-547 1.7e-24 81.9 In-house 13-169 (174) alignment 
Range on Protein: 410-547
Range on HMM: 13-169/174.0
SKIFDYLYLGTEWNAsNWEELSRNNCQYIINVTCEIEN---------------FFPDKIKYCNIRVWDVPTTTIWPnWNRTYDFIRQARKA--GSSVLVH
| | ..|..|    | .||.| ........... |.|.               . .  |.|. . . |  . ..   . . ..|...|..   |  ||||
syitprliagqgpla.fwemlkelgittvvmlleekelglykcinywpelredlerlgiqylylpwpDhgvpdlsi.llefvkfveealsedpggpvlVH

CKMGVSRSASTVIAYAMKQYSW-SLEEAHAFVKKRR---RIIKPNEGFRTQLVMYEGML
|..||.|..  |.|| |... . ||..| ..|...|     . ...... .|  .| .|
CsaGvgRtGtlvaaylmlrglleslvdaldlvrelRlqrpgmvqtpsQyrflyyfekll
0040438 (Phosphotyrosine protein) phosphatases II 425-544 8.9e-24 79.8 In-house 101-272 (317) alignment 
Range on Protein: 425-544
Range on HMM: 101-272/317.0
SNWEELSRNNCQYIINVTCEIEN---------------------------FFPDKIKYCNIRVWDV----------------PTTTIWPNWNRTYDFIRQ
. |. . ......|...| . |.                           .  . |.. ...|.|                 |  .. |...   ||...
dFwrmvweqgvtvivmLteleelgrekcaqYwplgetltygdftvtllseeelagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldflea

ARKA----GSSVLVHCKMGVSRSASTVIAYAM-----KQYSWSLEEAHAFVKKRRRIIKPNEGFRTQLVMYE
.|.|    |. |||||..||.|... ..|| |     | . ...||| ......|. . .....  .| ...
vrealedpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydal
PTEN_1 408-550 3.8e-23 77.3 In-house 41-194 (196) alignment 
Range on Protein: 408-550
Range on HMM: 41-194/196.0
PSsKIFDYLYLGTEWNA-SNWEELSRNNCQYIINVTCEIEN---------FFPDKIKYCNIRVWDVPTTTIWPNWNRTYDFIRQARK--AGSSVLVHCKM
.. .|.. ||.| .  . .....|  ..   ..|...| |.         ||  ...| .. . | .. ..   .   ..|| ....   |  |||||| 
lq.eideglyrgslkdvaadldnlkedgitlvvnlseeeelsgrsydleeffksgveylhfpieDhgapslselfdicksfiewllsdpngnvVlVHCka

GVSRSASTVIAYAMKQYSWSLEEAHAFVKKRRRIIKPNEGFRTQLVMYEGMLTAR
|..||.  |.|| |. . .. .|| ..|...|  . || ... .|. |. .| |.
GlgRsGtvvaayLmykgkltadeAlelvrekRppgapnspsqerlleyfaellae
0042113 (Phosphotyrosine protein) phosphatases II 413-544 2.2e-21 71.9 In-house 51-239 (245) alignment 
Range on Protein: 413-544
Range on HMM: 51-239/245.0
FDYLYLGTEWNASNWE----ELSRNNCQYIINVTCEIEN----------------------------------------------FFPDKIKYCNIRVWD
 . ....    ....|     | ......|...| | |.                                              .    | |. . . |
tpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywplgesltygdftvtllseehlddytvrtlevtnlgddesrevihyhylpwpd

VPTTTIWPNWNRTYDFIRQARK--AGSSVLVHCKMGVSRSASTVIAYAM-----KQYSWSLEEAHAFVKKRRRIIKPNEGFRTQLVMYE
 .....     . ..|.|.|..  ..  |||||..||.|..  ..|| |     | . .||||| ......|. . .....  .| ...
hgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylmleqlekelgvsleeavkelrsqRpgavqtpsqyrflyeal
subfamily_STYX_pd Subfamily STYX 427-549 2.3e-21 69.6 In-house 32-159 (166) alignment 
Range on Protein: 427-549
Range on HMM: 32-159/166.0
WEELSRNNCQYIINVTCEIE-----NFFPDKIKYCNIRVWDVPTTTIWPNWNRTYDFIRQARKAGSSVLVHCKMGVSRSASTVIAYAMKQYSWSLEEAHA
 | | ..   .|. .  .||       |||...|  . | | ..  |     .. .|| .. . |  |||| . |.||||. |||| |. |     ||.|
levlkkhgithivcirqnieanlikpnfpdrfrylvldvadntveniirylptvkefiddslqkggkvlvhgnagisrsaalviayimetyglkyreafa

FVKKRRRIIKPNEGFRTQLVMYEGMLTA
.|..||  |.||||| .||  || .  |
yvqerrfcinpnegfvsqlkeyeaiyla
0038934 (Phosphotyrosine protein) phosphatases II 416-547 4.3e-21 70.9 In-house 38-176 (194) alignment 
Range on Protein: 416-547
Range on HMM: 38-176/194.0
LYLGTEWNASNWEELSRNNCQYIINVTCEIENFFPDKIKYCNIRVWDVPTTTI--WPNWNRTYDFIRQA-----RKAGSSVLVHCKMGVSRSASTVIAYA
||  . ..  .. .|   .. ..|..|..   . |....  .|.. . |.      |. . ...|.. .     ...|  |.||||.|..|..  |.|| 
lyrfspedlvrylkllnvklglvidltnteryYdpeefekagieylklpfpddgtvPsleillrfldlvdeflnedpggvvaVHCkaGlgRtGtlvaaYL

MKQYSWSLEEAHAFVKKRRRIIKPNEGFRTQLVMYEGML
.. . .|.||| |... .|. . || ..  .|... ..|
iyrlgmsaeeAialfrekRpgaipnqdyleallkrykel
0036941 (Phosphotyrosine protein) phosphatases II 407-546 2.7e-20 68.3 In-house 17-275 (297) alignment 
Range on Protein: 407-546
Range on HMM: 17-275/297.0
EPSSKIFDYLYLGTEWNASNWEELSRN----------------------------------------------------------NCQYIINVTCEIEN-
.  ......|.||. . |...| |..|                                                          |.. |...| ..|. 
kefeellpllllgslsvallpenleknRykdilpydhtRVklddegsdYinAsyvdgydlkrkfIatqgPlpntvedFWrmvweqnvtvIvmltelvelg

------FFPDK-----------IKYCNIRV-----------------------------WDVPTTTIWPNWNRTYDFIRQARK------AGSSVLVHCKM
      ..|..           ... .. |                              . |   . ....   |||...||       |. |||||..
rekcaqywpleegesltygdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfielvrkvlkllpsggpvlVHCsa

GVSRSASTVIAYAM--------KQYSWSLEEAHAFVKKRRRIIKPNEGFRTQLVMYEGM
||.||.. ..|. |        |.. ... ||  .....|  . .....  .| ... .
GvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyealle
subfamily_STYXL1_pd Subfamily STYXL1 413-547 7.1e-20 64.8 In-house 16-153 (157) alignment 
Range on Protein: 413-547
Range on HMM: 16-153/157.0
FDYLYLGTEWNASNWEELSRNNCQYIINVTCEIENFF---PDKIKYCNIRVWDVPTTTIWPNWNRTYDFIRQARKAGSSVLVHCKMGVSRSASTVIAYAM
 . ||||.. .| | .       .  .||. . ....   .|  |  .|.| |.. . . .. ..  .|| . .| |. |||  . |.||||. .||| |
PgklylGnykqaqnpaikkdlkvkahvnvsmdadkliagvadvakllhiavedeneadllerlkeavqfiekhkkegevvlvfsnkGisrsaaviiaylm

KQYSWSLEEAHAFVKKRRRIIKPNEGFRTQLVMYEGML
 .. ..|..|....|| .  .||| .|  ||  .| .|
yskkitlkkaykylkkCkenvkPnrafveqlseWekql
0039614 (Phosphotyrosine protein) phosphatases II 426-546 2.1e-19 65.5 In-house 63-287 (297) alignment 
Range on Protein: 426-546
Range on HMM: 63-287/297.0
N------------------------------------------------------WEELSRNNCQYIINVTCEIEN--------------------FFPD
                                                       |. . ......|...| ..|.                     . .
kdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfIatqgPlpetvedFwrmvweqgvtvivmLtklvelgrkcaqywpeeggtygdftvtllk

KIKYCNIR-------------------VWDVPTTTIWPNWNRTYDFIRQARK------AGSSVLVHCKMGVSRSASTVIAYAM-----KQYSWSLEEAHA
 ... ..                    . . |  .. |. .  ..|....|.       |  |||||..||.|... ..|| |     | . ....|| .
vehldgytvrtlevtnngesrtvthfqytgwpdhgvppslellleflelvrealaelpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavk

FVKKRRRIIKPNEGFRTQLVMYEGM
.....|. . .....  .| ... .
elreqRpgavqtpsqyrflydalle
subfamily_PTPMT1_pd Subfamily PTPMT1 445-546 4.6e-19 63.5 In-house 66-167 (171) alignment 
Range on Protein: 445-546
Range on HMM: 66-167/171.0
IENFFPDKIKYCNIRVWDVPTTTIWPNWNRTYDFIRQARKAGSSVLVHCKMGVSRSASTVIAYAMKQYSWSLEEAHAFVKKRRRIIKPNEGFRTQLVMYE
 |..    ... .....|.  .. . . ... .||.. .. |..| |||| | .|||. |..| ||.. .|.|||. ..||.|.||. ..  ...|  ||
teewkklgveqlqlatvDfteapdleklekgvefiekvaskgkrvYvHCkaGrgRsatlvacylmkkeklspeeAlkalkkkRkiirlakkqwkalqeye

GM
  
ek
0051429 (Phosphotyrosine protein) phosphatases II 414-544 4.9e-18 61.2 In-house 22-221 (272) alignment 
Range on Protein: 414-544
Range on HMM: 22-221/272.0
DYLYLGTEW---NASNWEELSRNNCQYIINVTCEIENFFPD------KIKYCNIRVWDVPTTTIWPNW--------------------------------
..||..  .   .| ... | .... .|.... | |  . .       |.|... ..|  ..||  ..                                
grlyrsggplpltaadfwrlkelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseellldyilrellltlllsageare

----------------NRTYDFIRQARKaGSSVLVHCKMGVSRSASTVIAYAMKqYSWS--------------LEEAHAFVKKRRRIIKPNEGFRTQLVM
                .   ..... .. |  |||||. |..|..  | .. .  . .|              |||| . ....|. . ..|... .| .
vmhlhytdwpdhgvpqeallellellld.ggpvlvHCsaGkdRTGtvvalllll.lgvsletivddYlltnlyleeaveelraqrpgavqteeqylflye

YE
..
al
subfamily_MSG5_pd Subfamily MSG5 437-550 8e-18 58.1 In-house 50-163 (165) alignment 
Range on Protein: 437-550
Range on HMM: 50-163/165.0
YIINVTCEIENF--FPDKIKYCNIRvWDVpTTTIWPNWNRTYDFIRQARKAGSSVLVHCKMGVSRSASTVIAYAMKQYSWSLEEAHAFVKKRRRIIKPNE
 .|||. ||...      .||  |. |.  .. |  . .|    |  |.  .  .||||. |.||||| ..|| || |. ||..|.  .| .   |.|. 
lvinvakeindlellvpavkyyhie.weh.dskivkdlsrltriihaatskrkkilvhcqcglsrsaslivayimkyynlslrdaydklksvaddispsi

GFRTQLVMYEGMLTAR
|.  ||. .| .|...
glifqlmewevalskk
0043336 (Phosphotyrosine protein) phosphatases II 427-544 3.9e-16 54.8 In-house 105-273 (278) alignment 
Range on Protein: 427-544
Range on HMM: 105-273/278.0
WEELSRNNCQYIINVTCEIEN------------------------------------------FFPDKIKYCNIRVWDVPTTTIWPNWNRTYDFIRQARK
|. .  .... |...| . |.                                            . . . . .   ..|  .. .. .   ||....|.
wrmvwelgvttivmLtelvelgrvkcaqYwpggsltygdftvtllkeehlddytvrtlevtnlgdgesrtvthyhylgwpdhgvpeslsllldflkavre

----AGSSVLVHCKMGVSRSASTVIAYAM-----KQYSWSLEEAHAFVKKRRRIIKPNEGFRTQLVMYE
     .. |||||. ||.|..  ...| .     | . ..|||| ......|  . ... .  .| ...
aledsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflyeal
DEK_C DEK C terminal domain 352-401 5e-15 44.7 Pfam-A 2-51 (54) alignment 
Range on Protein: 352-401
Range on HMM: 2-51/54.0
EQRIISKLKEIMFKSDLDTITSKQLRLQLEAEFDMDLKKYRKIIDQQMIT
.. | ....||. ..||.|.|.||.| .|||....||. ... |....  
deeikeevreiLkeaDLetvTkkqvrkeLearlgvdLserKafIkdliee
SAM_1 SAM domain (Sterile alpha motif) 959-1019 7e-15 42.5 Pfam-A 3-63 (64) alignment 
Range on Protein: 959-1019
Range on HMM: 3-63/64.0
WTSSEVVAWLEQAGLAEYGPLFAREELQGCDLLDLCNDDLKSIGIMTLHARKRILRACRAL
|. ..|. |||. ||..|  .|...|  |  || |  .||...|.  |  ||.||.. . |
wsvedVgeWLesiglgqYadnFrageidgdaLlllteedLeklgvtllGHrkkIlssIqrl
0047943 (Phosphotyrosine protein) phosphatases II 427-540 4.4e-14 48.1 In-house 94-264 (273) alignment 
Range on Protein: 427-540
Range on HMM: 94-264/273.0
WEELSRNNCQYIINVTCEIEN-------FFPDKIK---------------------------------------YCNIRVWDVPTTTIWPNWNRTYDFIR
|  .  .|...|. .| ..|.       ..|..                                         .. . . . |   . |...   .||.
wrmvweqnvrviVmLtelvelgrekcaqYwpleggelsltygkftvtllseetkddytvrtleltnlgtgesrtvthfhytgwpdhgvppslesllefie

QARK------AGSSVLVHCKMGVSRSASTVIAYAM-----KQYSWSLEEAHAFVKKRRRIIKPNEGFRTQL
..||       .. |.|||. ||.|... .... .     | . ....|| ......|  . ... .. .|
lvrkalealpsngpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrfl
0051299 (Phosphotyrosine protein) phosphatases II 427-533 2.8e-13 45.5 In-house 109-271 (288) alignment 
Range on Protein: 427-533
Range on HMM: 109-271/288.0
WEELSRNNCQYIINVTCEIEN-----------------------------------------------FFPDKIKYCNIRVWDVPTTTIWPNWNRTYDFI
|  .  .|...|. .| ..|.                                               .   ....  . . . |   . ....   ||.
WrmvweqnvrvIvmltklvelgrekcaqYwplggsltygditvtllseevlddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpdspellldfl

RQARKA----GSSVLVHCKMGVSRSASTVIAYAM-----KQYSWSLEEAHAFVKKRRRIIKPN
|..|||    |. |.|||. ||.|..  .... .     |.. ....|| ......|  . ..
rlvrkalasgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqt
SAM_2 SAM domain (Sterile alpha motif) 958-1019 3.6e-13 36.7 Pfam-A 3-65 (66) alignment 
Range on Protein: 958-1019
Range on HMM: 3-65/66.0
RWTSSEVVAWLEQAGLAEYGPLFAREELQG-CDLLDLCNDDLKSIGIMTLHARKRILRACRAL
 |....|  ||.. ||..| . | . .. | . || |  .||| .||     ||.||.....|
swsledvaeWLrsiglkqYadnFrdqgitgaelllrlteedLkrlGitsvghrkkilkkiqrl
0050432 (Phosphotyrosine protein) phosphatases II 427-529 8.5e-13 43.7 In-house 125-280 (308) alignment 
Range on Protein: 427-529
Range on HMM: 125-280/308.0
WEELSRNNCQYIINVTCEIEN-------FFPDKIK-----YCNIR----------------------------------VWDVPTTTIWPNWNRTYDFIR
|  .  .|...|. .| ..||       ..|....     | ...                                    . |   . |...   ||..
wrmvweqnvrvIvmLtklvengrekcaqYwplelgggsleygkftvtllseevlddytvrtleltnlgdgesrtvthfhytnWpdhgvPpspeilldfle

QARKA--GSSVLVHCKMGVSRSASTVIAYAM-----KQYSWSLEEAHAFVKKRRRI
..||   |. ..|||. ||.|..  .... .     |.. ....|| ......|  
lvrkslpggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpg
subfamily_Sponge-DSP-Subfam1_pd Subfamily Sponge-DSP-Subfam1 471-544 1.4e-11 37.7 In-house 65-138 (145) alignment 
Range on Protein: 471-544
Range on HMM: 65-138/145.0
NWNRTYDFIRQARKAGSSVLVHCKMGVSRSASTVIAYAMKQYSWSLEEAHAFVKKRRRIIKPNEGFRTQLVMYE
 ..   ||| . .. |. |.|||  ||||| .  .|. ||  . .| ||   |. .|    ||  |  .|.  |
hfdevtdfidkgkeegagvfvhcmagvsrsvtvsvaflmkycnmtlseaarqvrsnrllaypnvtflknllnle
0046845 (Phosphotyrosine protein) phosphatases II 427-528 4.5e-11 38.1 In-house 94-254 (284) alignment 
Range on Protein: 427-528
Range on HMM: 94-254/284.0
WEELSRNNCQYIINVTCEIENF-------FPD--------------------------------------KIKYCNIRVWDVPTTTIWPNWNRTYDFIRQ
|  .  .|...|. .| ..||        .|.                                       ..   . . . |   . |. .   .|.|.
wrmvweqnvrvIVmltelvengrekcaqYwplegevltygdftvtllseevkddytvrtleltnlgytgesrtvthfhytswpdhgvppspedlleflrl

ARKA------GSSVLVHCKMGVSRSASTVIAYAMKQY--------SWSLEEAHAFVKKRRR
.|..      |. ..|||. ||.|..  .... ....         ....|| ......| 
vrellenlpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRp
0048567 (Phosphotyrosine protein) phosphatases II 471-527 1.5e-07 25.9 In-house 52-118 (157) alignment 
Range on Protein: 471-527
Range on HMM: 52-118/157.0
NWNR-------TYDFIRQARKAGSSVLVHCKMGV---SRSASTVIAYAMKQYSWSLEEAHAFVKKRR
|...        ..|... ..||  . ||||.|    .|.|  . .|... .... ||| |...  |
nlailyrFilklnkflkilelagkaiavhckaglkkrgrtatLigcYlilhlgftpeeaiaplrivr
subfamily_RNGTT_pd Subfamily RNGTT 428-532 4.2e-07 23.8 In-house 48-160 (189) alignment 
Range on Protein: 428-532
Range on HMM: 48-160/189.0
EELSRNNCQYIINVTCEIENFFPDKIKYCNIRVWDVPTT--TIWPNWNRTYDFIRQ-----ARKAGSSVLVHCKMGVSRSASTVIAYAMKQYSWSLEEA-
 .. ...  ..|..| .   .  .... ..|.   . ..     |. ...  ||.      .... . . |||. |  |.   ...| ... .||.|.| 
lktlkvklglvidltntsryYdkeelekegikyvklqcagkgeaPeaeqvkefiklveeffkknpeevigvhCthGfnRtGFlivsyLvekedwsveaav

HAFVKKRRRIIKP
..| | |   |. 
alFakaRppGiyk
subfamily_CDC14_pd Subfamily CDC14 477-526 9.1e-07 23.0 In-house 254-303 (328) alignment 
Range on Protein: 477-526
Range on HMM: 254-303/328.0
DFIRQARKAGSSVLVHCKMGVSRSASTVIAYAMKQYSWSLEEAHAFVKKR
 |.. | ||  .. |||| |. |  . . .| ||.|  . .|| |...  
kfleiaekaeGaiavhCkaGLGrtGtLiacylmkhyrftaaeaiawlric
subfamily_Laforin_pd Subfamily Laforin 463-529 6.2e-06 19.2 In-house 87-153 (183) alignment 
Range on Protein: 463-529
Range on HMM: 87-153/183.0
VPTTTIWPNWNRTYDFIRQARKAGSSVLVHCKMGVSRSASTVIAYAMKQYSWSLEEAHAFVKKRRRI
. | .   |  ..  ..    . |  | |||. || ||.. |  . .    |||     |.  .| .
lstesrvenlpqavyllhallekghivyvhcnagvgrstaivcgflqyvlgwslakvqyfllakrpv