Gene MTMR14 in Monosiga brevicollis

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family Myotubularin
Subfamily MTMR14
Protein sequence
ID Type Fasta BLAST phosphatome Note
MbreP022_AA protein Get Run
MbreP022_AA_311-497 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_MTMR14_pd Subfamily MTMR14 107-498 6.6e-162 530.3 In-house 1-352 (357) alignment 
Range on Protein: 107-498
Range on HMM: 1-352/357.0
RVVRTLLERDYHVRAIDNRNGRLCSHYPFELYIL-----EGHKGSDELINNA---DELDMVFSgESQYARCRRRFVVPVILIDSMNICRSATLSRSGEIV
..|..||.|||....|||.||.|||.||..|.||     ||..|..||...|   ..|..... ...|||||.||||||||.|..|||||||||...||.
kkveellkrdyslsvidntnGelcsrypvkllileyelgegsegekelvesaydvqrlrellt.kakyarcrerfvvpvilldgknicrsatlsvaaeiy

YRqsctavskvYGALWEDASTEAAAHARQNNELIPATSDsvymaaatatdmatAQERMSALERCRRADVELLRHLRVQFIADLMIEKKKVKYGLHVSSSE
.|         .|. ......|.|.......||| |..|              ..|....|.|.|..|..||..|.|..|.|||.|||||||||.|||||
gr.........sGlnylasggeeadadkedeelitaked..............qaeeqalldrvrksdikllktlkvklivdlmvekkkvkyglavssse

KADTSGMYDSFDLVALPYPGVEWFNSMREQHYnpfkivrslpvlvpvsfltipCMACTFFNWSHPEVSVDLTIPKQARALVDTDWSNYKKWDLVTLTKNY
|||.. .|..|.|..|||||||.|...|...|                     .....|.||...||...|.||....| ||.|||.|||||||.||.||
kadkekrykdftllslPyPGveffkkfrdnky.....................saknlfynWkqdevdaelniPdklaasvdidwseykkWdlvaltqny

LKLMLAHIrtnKEDADQGLLVHCISGWDRTPLFTSLLRLSLWADGLIHQSLSAEEMLYLTVGYDWLLFGHLLPSRLNKGEEIFLFCFDVLQYLDSDEFSL
|||.|...   |||.|.||||||||||||||||.|||||||||||||||||||.|.|||||.|||.|||| ||.||.|||||..||||||....|.|||.
lklllkyv...kededsGllvhcisGWdrtPlfvsllrlslWadglihqslsaaellyltvaydWflfghqlpdrlkkgeeilffcfdvlkfitseefsi
0040695 (Phosphotyrosine protein) phosphatases II 106-497 2.7e-30 99.4 In-house 15-316 (388) alignment 
Range on Protein: 106-497
Range on HMM: 15-316/388.0
ARVVRTLLERDYHVRAIDNRNGRLCSHYPFELYileghkgsdelinnadeldmVFS-----GESQYARCRRRFVVPVILI----DSMNICRSATLSRsge
 .. |. |..|.    | |.|. ||..||  |.                    | .        ..||.|... .||..     . . ..||...     
relkrlglgldlwrisivNenyelcpsYPallv....................VPksisdellkrvarfrskgriPvlsyrhpnngavllRssqplv...

ivyrqsctavskvygalwedasteaaaharqnnelipatsdsvymaaatatdmATAQERMSALERCRRADVELLRHLRVQFIADLMiekKKVKYGLHVSS
                                                      ..  |. . |. ..|...||. |.. .| ||.   .|... . . .
.....................................................glllsrsledeklleailkllpnlskllivdlr...pklnalanral

SEKADTSGMYDSFDLVALPYPGVEWFNSmreqhynpfkivrslpvlvpvsfltiP---------------------Cmactffnwshpevsvdltipkqa
... .  ..| ...|. |..|.......                                                                        
gggvenedaypnaeliflnipnihvvre..........................slqklldaclnvpdslnllslle.......................

ralvdtdwsNYKKWDLVTLTKNYLKLMLAHIRtnkeDADQGLLVHCISGWDRTPLFTSLLRLSLWADgliHQSLSAEEMLyltVGYDWLLFGHLLPSRLN
         ... .||. |. ....|.. ...    . . ..||||..|||||....||..|.|...   ...|    .|   . ..||.||| ...||.
.........esgwldliklilelavlivklld....lgnssvlvhcsdgwdrtsqlssLaqllldPy...YRTleGFqvL...iekeWlsfghkfadRlg

KGEE---------------------------IFLFCFDVLQYLDSDEFS
 .|.                           .| |.. .| .|    .|
hleseidskefsPvFllFLdcvwqLlrqfPtaFeFnerlLlfLadhlys
subfamily_MTMR3_pd Subfamily MTMR3 410-492 1.1e-07 24.0 In-house 265-344 (442) alignment 
Range on Protein: 410-492
Range on HMM: 265-344/442.0
KEDADQGLLVHCISGWDRTPLFTSLLRLSLwaDGlIHQSLSAEEMLyltVGYDWLLFGHLLPSRLNKGEEI---FLFCFDVLQYLD
 .   . .||||  |||||.  ..| .| |  |   ...|   ..|   |  .|| ||| .  |   ||..      |   ||.||
vdkegrpvlvhCsdGWdrttqivalaklll..dp.yyrtleGfkvl...vereWldfGhkfadrcghgenvddanercPvflqwld
subfamily_MTMR1_pd Subfamily MTMR1 409-479 1.6e-07 22.9 In-house 207-271 (389) alignment 
Range on Protein: 409-479
Range on HMM: 207-271/389.0
NKEDADQGLLVHCISGWDRTPLFTSLLRLSLwaDGLiHQSLSAEEMLyltVGYDWLLFGHLLPSRLNKGEE
. |   .  ||||  |||||  .|||  | |  |   .....  |.|   .  .|| ||| . .|| .|..
kvetektsvlvhcsdGWDRtaqltsLamlll..Dsy.yRtieGfevl...iekeWlsfGHkfkeRlghgdk
0051429 (Phosphotyrosine protein) phosphatases II 374-442 1e-06 24.2 In-house 115-178 (272) alignment 
Range on Protein: 374-442
Range on HMM: 115-178/272.0
QARALVDTDWSNYKKWDLVTLTKNYLKLMLAHIRTnkedaDQGLLVHCISGWDRTPLFTSLLRLSLWAD
.| .     .  |  |      ...|. .|.....     .. .|||| .|.||| ..  ||.| |  .
sagearevmhlhytdwpdhgvpqeallellellld.....ggpvlvHCsaGkdRTGtvvallllllgvs
subfamily_Dicty-MTMR1-like_pd Subfamily Dicty-MTMR1-like 407-476 1e-06 20.2 In-house 215-278 (404) alignment 
Range on Protein: 407-476
Range on HMM: 215-278/404.0
RTNKEDADQGLLVHCISGWDRTPLFTSLLrlSLWADGlIHQSLSAeemLYLTVGYDWLLFGHLLPSRLNK
 .  |.  .  ||||. |||||.  .||    | .|   .. ...    .  .  .|| |||.  .| ..
veliekekssvlvhcsdgwDrtsqlssls..qllldp.yyrtieg...FivliekewlsfGhkfaqRigq
0051082 (Phosphotyrosine protein) phosphatases II 265-438 1.3e-06 23.6 In-house 24-116 (151) alignment 
Range on Protein: 265-438
Range on HMM: 24-116/151.0
ADVELLRHLRVQFIADLMIEKKKVKYGLHVSSSEkadtsgmydsfdlvalpypgvewfnsmreqhynpfkivrslpvlvpvsfltI-----PCMACTFFN
...|||..| .. | .|. |.   ..   . . .                                                   |     |..  ....
dflellkelgiktivnlrseeergycpeylpelg...................................................ievlhipildwpdpg

wshpevsvdltipkqaralvdtdwsnykkwdlvtlTKNYLKLMLAHIRTNKEDADQGLLVHCISGWDRTPLFTSLLRLS
                                   .  ... .|. ..   .. .. .|||| .|..|| ..  |... 
...................................lplsfdavleflellldkkngpvlvHCsaGkgRTGtlvalylml
0049772 (Phosphotyrosine protein) phosphatases II 390-441 4.3e-06 22.2 In-house 190-241 (314) alignment 
Range on Protein: 390-441
Range on HMM: 190-241/314.0
DLVTLTKNYLKLMLAHIRTNkeDADQGLLVHCISGWDRTP--LFTSLLRLSLWA
|  . . .... .|..|...  |..  .|||| .|..||.  ... .| . |. 
Dgsaplledfdeflefieea..dkggpvlvHCkaGkgRtgtfvvaaylmkllgv
subfamily_Ank-MTMR1_pd Subfamily Ank-MTMR1 415-475 4.8e-06 17.6 In-house 234-288 (405) alignment 
Range on Protein: 415-475
Range on HMM: 234-288/405.0
QGLLVHCISGWDRTPLFTSLLRLSLwaDGLiHQSLSAeemLYLTVGYDWLLFGHLLPSRLN
. .||||  ||||||  ||| .. |  |   ....     . . .  .|| ||| .  || 
nsilvhcsdgwdrtpqitsltqill..dpy.yrtivg...fqvliekewlsfghkfslrlg
Myotub-related Myotubularin-like phosphatase domain 412-477 7.6e-06 17.9 Pfam-A 229-288 (353) alignment
Myotub-related Myotubularin-like phosphatase domain 412-477 7.6e-06 17.9 In-house 229-288 (353) alignment