Gene OCA-1 in Monosiga brevicollis

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family OCA
Subfamily OCA
Protein sequence
ID Type Fasta BLAST phosphatome Note
MbreP026_AA protein Get Run
MbreP026_AA_14-373 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
0051429 (Phosphotyrosine protein) phosphatases II 322-447 6e-27 90.4 In-house 133-271 (272) alignment
Range on Protein: 322-447
Range on HMM: 133-271/272.0
LKYSRHMLCRGLKIVATqaHHPVLVHCFHGKDRTGLLVALVLSILKVPRESIIMDYHYSERF---------------GSSEQGRAHFAKVPQLNADTWCL
  . .. |.. |.....  ..||||||..||||||..|||.|..| |..| |. ||.... .               . .|. ..   .. . .....  
hgvpqeallellellld..ggpvlvHCsaGkdRTGtvvallllllgvsletivddYlltnlyleeaveelraqrpgavqteeqylflyeallellrslls

APTEVMRQTLDHLDQEYDGIEAYCDKIGFNDHWRARLRSAL
.. |.....||..|.||...|.|  ..|.......|||. |
vraeyllaaldaideeyGsvegYLrdlglseeelerLrell

subfamily_OCA_pd Subfamily OCA 298-448 4.3e-24 75.4 In-house 136-277 (282) alignment
Range on Protein: 298-448
Range on HMM: 136-277/282.0
KEEAKNHMITKFNDMGLIGLNRIilkysRHMLCRGLK-IVATQAHHPVLVhcfhgkDRTGLLVALVLSILKVPRESIImDYhyserFGSSEQGRAHFAK-
................|.  ...     ...... |. ........|.|.      ||.||..||.|.  .|.||.|. |.     . |||.. ..... 
hffprlyslvpprnfslveeykd.....kpvisgllrlllpeeenlpfLi......drlglktaliLdaeeveretia.df.....lasseiklvslrne

VPQLNADTWCLA-------PTEVMRQTLDHlDQEYDGIEAYCDKIGFNDHWRARLRSALC
| .   |....|        |... . |.. |..|. .. |...|||. .....|.|.|.
vlkdlldndnyavelscqaktdtvlkvLrk.dkkygstsiyleyigFtledqeslksill

Y_phosphatase3 Tyrosine phosphatase family 307-380 1.1e-16 56.3 Pfam-A 91-163 (164) alignment
Range on Protein: 307-380
Range on HMM: 91-163/164.0
TKFNDMGLIGLNRIILKYSRHMLCRGLKIVATQAhHPVLVHCFHGKDRTGLLVALVLSILKVPRESIIMDYHYS
.. ..  .  ..| ||. ... . . |...|... .|||.|| .||||||...||.||.| |..| |. ||  .
aeeaeeamaeayreiledekkayrkvlealaeee.gpvlfHCtaGKDRTGvvaalllsllgvdeetiaaDYllt

0051429 (Phosphotyrosine protein) phosphatases II 17-90 3.7e-15 51.8 In-house 3-68 (272) alignment
Range on Protein: 17-90
Range on HMM: 3-68/272.0
FATFVNFRDLSVLDTRIKPHRFYRSATPSTLTSEDVVVLlEQLGVKTIIDLRDRSEAEHDPGDRLVqhcfgiaP
. . .|.||.. .  ..||.|.|||. |..|| .|.  | ..||.|||.|||. .| .... ||.        |
lsgyiNardvggygrvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdryw.......p

0051082 (Phosphotyrosine protein) phosphatases II 324-380 7.3e-14 47.1 In-house 75-131 (151) alignment
Range on Protein: 324-380
Range on HMM: 75-131/151.0
YSRHMLCRGLKIVATQAHHPVLVHCFHGKDRTGLLVALVLSILKVPRESIIMDYHYS
 | . . . |.... . ..|||||| .||.|||.||||.| .|.|. |... .|. .
lsfdavleflellldkkngpvlvHCsaGkgRTGtlvalylmllgvsleealeeyrlk

Y_phosphatase3 Tyrosine phosphatase family 22-83 4.2e-13 44.6 Pfam-A 1-64 (164) alignment
Range on Protein: 22-83
Range on HMM: 1-64/164.0
NFRDLSVLDT----RIKPHRFYRSATPSTLTSEDVVVLLeQLGVKTIIDLRDRSEAEHDPgDRLVQ
|||||  ..|    ...|...||||. |.||..|. .|  .||.||..|||...|.|..| |.|..
NfRDlGgyptadgrtvrpgvlyRSaalsklteadlaaLa.elgiktvvDLRseeEvekep.dklpe

0049772 (Phosphotyrosine protein) phosphatases II 333-378 3.3e-11 39.0 In-house 203-251 (314) alignment
Range on Protein: 333-378
Range on HMM: 203-251/314.0
LKIVAT-QAHHPVLVHCFHGKDRTG--LLVALVLSILKVPRESIIMDYH
|... . ....|||||| .||.|||  ...|.... |.|. | .. |..
lefieeadkggpvlvHCkaGkgRtgtfvvaaylmkllgvsleealedvr

0041856 (Phosphotyrosine protein) phosphatases II 33-365 5.8e-11 37.8 In-house 31-133 (182) alignment
Range on Protein: 33-365
Range on HMM: 31-133/182.0
IKPHRFYRSATPSTLTSEDVVVLLEQLGVKTIIDLRdrsEAEHDPgdrlvqhcfgiapqahevivdrlealddpqtfqahleglevapmdkphehhhhlp
 .. ||    .|   | .| . .| .||..||..|.   |  ..|                                                       
lpatrfiatqgpllstvadflrmlkelgittivnlt...eelywp.......................................................

hlrhlrhlrhgskshghedvessadpsgpvldqetpaeqarvvratyhhtpearqpieelahgdwaasresspssptdspddieevdlqlchdldertra
                                                                                                    
....................................................................................................

espqqvhneamrvqnefgtkarlkyflplaersvmtrallsevtwydklyvgakytlglavnSEYKEEAKNHMITKFNDMGLIGlNRIILKYSRHMLCrg
                                                              .... .  ... . . |.|     ...|.. . .|   
..............................................................ellerlgiqylylpwpDhgvpd.ldelldfieevle..

lkivatqAHHPVLVHCFHGKDRTGLLVALVLSI
        ..|||||| .|..||| |||. | .
.......eggpvlVHCsaGvgRtgtlvaaylmk

Y_phosphatase3C Tyrosine phosphatase family C-terminal region 409-447 1.6e-10 30.5 Pfam-A 28-67 (68) alignment
Range on Protein: 409-447
Range on HMM: 28-67/68.0
TEVMRQTLDHLDQEYDGIEAYC-DKIGFNDHWRARLRSAL
.| ....||..|..| ..|.|  ...|. .. ..|||. |
eeyleaaldtideryGsvegYLeeaLGlseedierLRerl

0042113 (Phosphotyrosine protein) phosphatases II 328-377 2.1e-10 35.9 In-house 163-218 (245) alignment
Range on Protein: 328-377
Range on HMM: 163-218/245.0
MLCRGLKIVATQAHHPVLVHCFHGKDRTGLLVALVL------SILKVPRESIIMDY
.| . .|..|  ...|||||| .|..|||...|. |      . |.|. |... ..
flefvrkalaedsngpvlVHCsaGvgRtGtfiaaylmleqlekelgvsleeavkel

Y_phosphatase2 Tyrosine phosphatase family 322-378 5.2e-10 31.4 Pfam-A 72-128 (165) alignment
Range on Protein: 322-378
Range on HMM: 72-128/165.0
LKYSRHMLCRGLKIVATQAHHPVLVHCFHGKDRTGLLVALVLSILKVPRESIIMDYH
 .   ..| . ||.. .....|||.|| .|| ||||... .  . | .  ||. .|.
veiksdllkkalklllnkenypvllhckrGkhrtglvigclRklqkWslasilnEyr

0043336 (Phosphotyrosine protein) phosphatases II 327-377 1.6e-09 33.1 In-house 193-252 (278) alignment
Range on Protein: 327-377
Range on HMM: 193-252/278.0
HMLCRGLKIVAT---QAHHPVLVHCFHGKDRTGLLVALVL------SILKVPRESIIMDY
 .|.. ||.| .     ..|||||| .|..|||...|| |      ....|. |... ..
sllldflkavrealedsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkel

0049260 (Phosphotyrosine protein) phosphatases II 303-373 2.4e-09 32.5 In-house 56-121 (152) alignment
Range on Protein: 303-373
Range on HMM: 56-121/152.0
NHMITKFNDMGLIGLNRIILKYSRHMLCRglkivATQAHHPVLVHCFHGKDRTGLLVALVLSILKVPRESI
... . . |.|   |  ..|   . . ..     | . ..||||||..|..|||.|||. | .|.|. | .
qylhlpwpDhgvpdlsqlllflllfiekl.....aldkggpvlVHCsaGvgRtgtlvaaylmllgvsleea

0048076 (Phosphotyrosine protein) phosphatases II 299-373 3.4e-09 32.1 In-house 45-114 (145) alignment
Range on Protein: 299-373
Range on HMM: 45-114/145.0
EEAKNHMITKFNDMGLIGLNRIILKYSRHMlcrglkIVATQAHHPVLVHCFHGKDRTGLLVALVLSIL-KVPRESI
..  ... . . |.|   | ...|.  . .        | ....|||||| .|..|||.|||. | .| .|. |..
rlgiqylylpwpDhgvpdllellleflefi......eealkeggpvlVHCsaGvgRtgtlvaaylmlllgvsleea

0040439 (Phosphotyrosine protein) phosphatases II 338-377 4.5e-09 31.8 In-house 175-221 (249) alignment
Range on Protein: 338-377
Range on HMM: 175-221/249.0
T-QAHHPVLVHCFHGKDRTGLLVALVLS------ILKVPRESIIMDY
.   ..|||||| .|..|||...|. |        |.|. |... ..
elpkggpvlVHCsaGvgRtGtfiaaylmleqlekelgvdleeavkll

0036282 (Phosphotyrosine protein) phosphatases II 303-366 4.9e-09 31.6 In-house 71-129 (174) alignment
Range on Protein: 303-366
Range on HMM: 71-129/174.0
NHMITKFNDMGLIGLNRiILKYSRHMLCRGLKivatQAHHPVLVHCFHGKDRTGLLVALVLSIL
... . . |.|   |.  .|.  . .    ..      ..|||||| .|..|||.|||. | . 
qylylpwpDhgvpdlsi.llefvkfveealse....dpggpvlVHCsaGvgRtGtlvaaylmlr

0037934 (Phosphotyrosine protein) phosphatases II 330-377 6e-09 31.3 In-house 167-216 (243) alignment
Range on Protein: 330-377
Range on HMM: 167-216/243.0
CRGLKIVATQAHHPVLVHCFHGKDRTGLLVALVLSIL--KVPRESIIMDY
 . | ..|   ..|||||| .|..|||.|.|. | .|  .|. |... ..
eellsllaldsggpvlVHCsaGvgRtGtliaaylmllllgvdleeavkll

0048179 (Phosphotyrosine protein) phosphatases II 303-368 6.9e-09 31.1 In-house 51-111 (144) alignment
Range on Protein: 303-368
Range on HMM: 51-111/144.0
NHMITKFNDMGLIGLNRIILKYSRHMLCRglkivaTQAHHPVLVHCFHGKDRTGLLVALVLS-ILKV
... . . |.|   |  ..|.  . .          . ..|||||| .|..|||.|||. |   |..
qylhlpwpDhgvpdllellleflefieea......leeggpvlVHCsaGvgRtgtlvaaylmkklgl

0043147 (Phosphotyrosine protein) phosphatases II 303-371 1.1e-08 30.5 In-house 67-130 (172) alignment
Range on Protein: 303-371
Range on HMM: 67-130/172.0
NHMITKFNDMGLIgLNRIILKYSRHMLCRGlkivATQAHHPVLVHCFHGKDRTGLLVALVLSILKVPRE
 .. . . |.|   | ...|.  . .  .     | . ..|||||| .|..|||.|||. | .|... |
qylylpwpDhgvp.llellleflefidell....alspggpvlVHCsaGvgRtgtlvaaylmllglsle

0039614 (Phosphotyrosine protein) phosphatases II 308-372 1.1e-08 30.4 In-house 192-259 (297) alignment
Range on Protein: 308-372
Range on HMM: 192-259/297.0
KFNDMGLIGLNRIILKYSRHMLCRGLKIvatQAHHPVLVHCFHGKDRTGLLVALVLS------ILKVPRES
.. |.|   . ...|.  . .  .  .    . ..|||||| .|..||| ..|. |         .|  ..
gwpdhgvppslellleflelvrealael...pkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvle

0045450 (Phosphotyrosine protein) phosphatases II 336-373 1.1e-08 30.7 In-house 228-266 (307) alignment
Range on Protein: 336-373
Range on HMM: 228-266/307.0
VATQ-AHHPVLVHCFHGKDRTGLLVALVLSILKVPRESI
...   ..|||||| .|..||| ..|. | .  . .| .
leelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegt

0044763 (Phosphotyrosine protein) phosphatases II 334-364 1.2e-08 30.3 In-house 103-133 (178) alignment
Range on Protein: 334-364
Range on HMM: 103-133/178.0
KIVATQAHHPVLVHCFHGKDRTGLLVALVLS
. .  . ..|||||| .|..|.|.|||. | 
eealdekggpvlVHCsaGvgRsgtlvaaylm

0045098 (Phosphotyrosine protein) phosphatases II 304-367 1.5e-08 29.9 In-house 159-232 (278) alignment
Range on Protein: 304-367
Range on HMM: 159-232/278.0
HMITKFNDMGLIGLN--RIILKYSRHMLCRGLKIVAT--------QAHHPVLVHCFHGKDRTGLLVALVLSILK
. .. . |.|   |.  . .|.. . .. .  ...          . ..|||||| .|..||| |||. | .  
lhylpwpdhgvpslpilksflellefirealkllaslllsslllldsggpvlVHCsaGvgRtGtlvaaylmlel

0038934 (Phosphotyrosine protein) phosphatases II 327-381 3.9e-08 28.7 In-house 97-167 (194) alignment
Range on Protein: 327-381
Range on HMM: 97-167/194.0
HMLCRGLKIV----ATQAHHPVLVHCFHGKDRTGLLVALVLSI------------LKVPRESIIMDYHYSE
 .|.| |..|    . .... |.||| .|. |||.|||  |              ..  | ..|. ..| |
eillrfldlvdeflnedpggvvaVHCkaGlgRtGtlvaaYLiyrlgmsaeeAialfrekRpgaipnqdyle

0040438 (Phosphotyrosine protein) phosphatases II 336-368 3.9e-08 28.4 In-house 201-242 (317) alignment
Range on Protein: 336-368
Range on HMM: 201-242/317.0
VAT---QAHHPVLVHCFHGKDRTGLLVALVLS------ILKV
| .   . ..|||||| .|..||| ..|. |         .|
vrealedpggpvlVHCsaGvgRtGtfiaaylmleqlekeggv

0046846 (Phosphotyrosine protein) phosphatases II 303-366 4.4e-08 28.6 In-house 78-134 (176) alignment
Range on Protein: 303-366
Range on HMM: 78-134/176.0
NHMITKFNDMGLIGLnRIILKYSRHMLCrglkivATQAHHPVLVHCFHGKDRTGLLVALVLSIL
 .. . . |.|   | ...|.  . .        | ....||||||..|. |||.|||. | .|
qylhlpwpDhgvpdl.elllellefire......alkeggpvlVHCsaGigRtgtlvaayllel

subfamily_OCA_pd Subfamily OCA 15-72 7.5e-08 22.1 In-house 139-197 (282) alignment
Range on Protein: 15-72
Range on HMM: 139-197/282.0
DPFATFVNFRDLSVLDT---RIKPHRFYRSATPSTLTSEdvvVLLEQLGVKTIIDLRDRS-E
 .....|..|..|....   ........|...|.... .   .|...||.||.. |.... |
prlyslvpprnfslveeykdkpvisgllrlllpeeenlp...fLidrlglktaliLdaeeve

PTPc_DSPc_SM00012 337-372 8.9e-08 27.7 In-house 38-70 (105) alignment
Range on Protein: 337-372
Range on HMM: 38-70/105.0
AtqaHHPVLVHCFHGKDRTGLLVALVLSILKVPRES
    ..||.|||..| .||| .||| . . .. .|.
s...skpvvVhCsaGvgRtgtfvaldillqqleket

0036941 (Phosphotyrosine protein) phosphatases II 339-368 4.4e-07 25.0 In-house 205-234 (297) alignment
Range on Protein: 339-368
Range on HMM: 205-234/297.0
QAHHPVLVHCFHGKDRTGLLVALVLSILKV
  ..|||||| .|. |.| ..|. | .  .
psggpvlVHCsaGvgRsgtfiaadlmlqql

0051299 (Phosphotyrosine protein) phosphatases II 321-368 4.8e-07 25.0 In-house 204-246 (288) alignment
Range on Protein: 321-368
Range on HMM: 204-246/288.0
ILKYSRHMLCRGLkivatQAHHPVLVHCFHGKDRTGLLVALVLSILKV
.|.. |..          . ..||.||| .|..||| ..|| | .  .
lldflrlvrkala.....sgggpvvVHCsaGvgRtgtfialdllleql

0042113 (Phosphotyrosine protein) phosphatases II 15-75 5.2e-07 24.8 In-house 31-91 (245) alignment
Range on Protein: 15-75
Range on HMM: 31-91/245.0
DPFATFVNFRDLSVLDTRIKPHRFYRSATPSTLTSEDVVVLLEQLGVKTIIDLRDRSEAEH
|..  ....   |  |.   ...|.... |.. | ||   .| .||..||..|..  | ..
dggdldsdyinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgr

0046845 (Phosphotyrosine protein) phosphatases II 338-372 5.2e-07 24.8 In-house 201-235 (284) alignment
Range on Protein: 338-372
Range on HMM: 201-235/284.0
TQAHHPVLVHCFHGKDRTGLLVALVLSILKVPRES
.  ..|..||| .|. ||| ..|| | .  . .|.
lpgggpivVHCsaGvgRtGtfialdllleqlekeg

0047943 (Phosphotyrosine protein) phosphatases II 339-366 9e-07 24.1 In-house 203-230 (273) alignment
Range on Protein: 339-366
Range on HMM: 203-230/273.0
QAHHPVLVHCFHGKDRTGLLVALVLSIL
  ..||.||| .|. ||| ..|| | . 
psngpvvVHCsaGvgRtgtfialdllld

0050432 (Phosphotyrosine protein) phosphatases II 337-367 1.1e-06 23.7 In-house 228-258 (308) alignment
Range on Protein: 337-367
Range on HMM: 228-258/308.0
ATQAHHPVLVHCFHGKDRTGLLVALVLSILK
 .. ..|..||| .|  ||| ..|| | .  
kslpggpivVHCsaGvGRtGtfialdllleq

PTEN_1 340-367 7.8e-06 20.8 In-house 129-156 (196) alignment
Range on Protein: 340-367
Range on HMM: 129-156/196.0
AHHPVLVHCFHGKDRTGLLVALVLSILK
 .. ||||| .|. |.|..||  |  ..
ngnvVlVHCkaGlgRsGtvvaayLmykg

Y_phosphatase Protein-tyrosine phosphatase 325-371 8.7e-06 20.7 Pfam-A 159-200 (235) alignment
Range on Protein: 325-371
Range on HMM: 159-200/235.0
SRHMLCRGlkivaTQAHHPVLVHCFHGKDRTGLLVALVLSILKVPRE
 | .  .      .. ..||.||| .|  ||| .||| . . .. .|
irkveksk.....eaksgpvvVhCsaGvgRtgtfvaldilleqleae

Y_phosphatase Protein-tyrosine phosphatase 325-371 8.7e-06 20.7 In-house 159-200 (235) alignment
Range on Protein: 325-371
Range on HMM: 159-200/235.0
SRHMLCRGlkivaTQAHHPVLVHCFHGKDRTGLLVALVLSILKVPRE
 | .  .      .. ..||.||| .|  ||| .||| . . .. .|
irkveksk.....eaksgpvvVhCsaGvgRtgtfvaldilleqleae