Gene OCA-1 in Monosiga brevicollis

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family OCA
Subfamily OCA
Protein sequence
ID Type Fasta BLAST phosphatome Note
MbreP026_AA protein Get Run
MbreP026_AA_14-373 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
0051429 (Phosphotyrosine protein) phosphatases II 322-447 6e-27 90.4 In-house 133-271 (272) alignment 
Range on Protein: 322-447
Range on HMM: 133-271/272.0
LKYSRHMLCRGLKIVATqaHHPVLVHCFHGKDRTGLLVALVLSILKVPRESIIMDYHYSERF---------------GSSEQGRAHFAKVPQLNADTWCL
  . .. |.. |.....  ..||||||..||||||..|||.|..| |..| |. ||.... .               . .|. ..   .. . .....  
hgvpqeallellellld..ggpvlvHCsaGkdRTGtvvallllllgvsletivddYlltnlyleeaveelraqrpgavqteeqylflyeallellrslls

APTEVMRQTLDHLDQEYDGIEAYCDKIGFNDHWRARLRSAL
.. |.....||..|.||...|.|  ..|.......|||. |
vraeyllaaldaideeyGsvegYLrdlglseeelerLrell
subfamily_OCA_pd Subfamily OCA 298-448 4.3e-24 75.4 In-house 136-277 (282) alignment 
Range on Protein: 298-448
Range on HMM: 136-277/282.0
KEEAKNHMITKFNDMGLIGLNRIilkysRHMLCRGLK-IVATQAHHPVLVhcfhgkDRTGLLVALVLSILKVPRESIImDYhyserFGSSEQGRAHFAK-
................|.  ...     ...... |. ........|.|.      ||.||..||.|.  .|.||.|. |.     . |||.. ..... 
hffprlyslvpprnfslveeykd.....kpvisgllrlllpeeenlpfLi......drlglktaliLdaeeveretia.df.....lasseiklvslrne

VPQLNADTWCLA-------PTEVMRQTLDHlDQEYDGIEAYCDKIGFNDHWRARLRSALC
| .   |....|        |... . |.. |..|. .. |...|||. .....|.|.|.
vlkdlldndnyavelscqaktdtvlkvLrk.dkkygstsiyleyigFtledqeslksill
Y_phosphatase3 Tyrosine phosphatase family 307-380 1.1e-16 56.3 Pfam-A 91-163 (164) alignment 
Range on Protein: 307-380
Range on HMM: 91-163/164.0
TKFNDMGLIGLNRIILKYSRHMLCRGLKIVATQAhHPVLVHCFHGKDRTGLLVALVLSILKVPRESIIMDYHYS
.. ..  .  ..| ||. ... . . |...|... .|||.|| .||||||...||.||.| |..| |. ||  .
aeeaeeamaeayreiledekkayrkvlealaeee.gpvlfHCtaGKDRTGvvaalllsllgvdeetiaaDYllt
0051429 (Phosphotyrosine protein) phosphatases II 17-90 3.7e-15 51.8 In-house 3-68 (272) alignment 
Range on Protein: 17-90
Range on HMM: 3-68/272.0
FATFVNFRDLSVLDTRIKPHRFYRSATPSTLTSEDVVVLlEQLGVKTIIDLRDRSEAEHDPGDRLVqhcfgiaP
. . .|.||.. .  ..||.|.|||. |..|| .|.  | ..||.|||.|||. .| .... ||.        |
lsgyiNardvggygrvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdryw.......p
0051082 (Phosphotyrosine protein) phosphatases II 324-380 7.3e-14 47.1 In-house 75-131 (151) alignment 
Range on Protein: 324-380
Range on HMM: 75-131/151.0
YSRHMLCRGLKIVATQAHHPVLVHCFHGKDRTGLLVALVLSILKVPRESIIMDYHYS
 | . . . |.... . ..|||||| .||.|||.||||.| .|.|. |... .|. .
lsfdavleflellldkkngpvlvHCsaGkgRTGtlvalylmllgvsleealeeyrlk
Y_phosphatase3 Tyrosine phosphatase family 22-83 4.2e-13 44.6 Pfam-A 1-64 (164) alignment 
Range on Protein: 22-83
Range on HMM: 1-64/164.0
NFRDLSVLDT----RIKPHRFYRSATPSTLTSEDVVVLLeQLGVKTIIDLRDRSEAEHDPgDRLVQ
|||||  ..|    ...|...||||. |.||..|. .|  .||.||..|||...|.|..| |.|..
NfRDlGgyptadgrtvrpgvlyRSaalsklteadlaaLa.elgiktvvDLRseeEvekep.dklpe
0049772 (Phosphotyrosine protein) phosphatases II 333-378 3.3e-11 39.0 In-house 203-251 (314) alignment 
Range on Protein: 333-378
Range on HMM: 203-251/314.0
LKIVAT-QAHHPVLVHCFHGKDRTG--LLVALVLSILKVPRESIIMDYH
|... . ....|||||| .||.|||  ...|.... |.|. | .. |..
lefieeadkggpvlvHCkaGkgRtgtfvvaaylmkllgvsleealedvr
0041856 (Phosphotyrosine protein) phosphatases II 33-365 5.8e-11 37.8 In-house 31-133 (182) alignment 
Range on Protein: 33-365
Range on HMM: 31-133/182.0
IKPHRFYRSATPSTLTSEDVVVLLEQLGVKTIIDLRdrsEAEHDPgdrlvqhcfgiapqahevivdrlealddpqtfqahleglevapmdkphehhhhlp
 .. ||    .|   | .| . .| .||..||..|.   |  ..|                                                       
lpatrfiatqgpllstvadflrmlkelgittivnlt...eelywp.......................................................

hlrhlrhlrhgskshghedvessadpsgpvldqetpaeqarvvratyhhtpearqpieelahgdwaasresspssptdspddieevdlqlchdldertra
                                                                                                    
....................................................................................................

espqqvhneamrvqnefgtkarlkyflplaersvmtrallsevtwydklyvgakytlglavnSEYKEEAKNHMITKFNDMGLIGlNRIILKYSRHMLCrg
                                                              .... .  ... . . |.|     ...|.. . .|   
..............................................................ellerlgiqylylpwpDhgvpd.ldelldfieevle..

lkivatqAHHPVLVHCFHGKDRTGLLVALVLSI
        ..|||||| .|..||| |||. | .
.......eggpvlVHCsaGvgRtgtlvaaylmk
Y_phosphatase3C Tyrosine phosphatase family C-terminal region 409-447 1.6e-10 30.5 Pfam-A 28-67 (68) alignment 
Range on Protein: 409-447
Range on HMM: 28-67/68.0
TEVMRQTLDHLDQEYDGIEAYC-DKIGFNDHWRARLRSAL
.| ....||..|..| ..|.|  ...|. .. ..|||. |
eeyleaaldtideryGsvegYLeeaLGlseedierLRerl
0042113 (Phosphotyrosine protein) phosphatases II 328-377 2.1e-10 35.9 In-house 163-218 (245) alignment 
Range on Protein: 328-377
Range on HMM: 163-218/245.0
MLCRGLKIVATQAHHPVLVHCFHGKDRTGLLVALVL------SILKVPRESIIMDY
.| . .|..|  ...|||||| .|..|||...|. |      . |.|. |... ..
flefvrkalaedsngpvlVHCsaGvgRtGtfiaaylmleqlekelgvsleeavkel
Y_phosphatase2 Tyrosine phosphatase family 322-378 5.2e-10 31.4 Pfam-A 72-128 (165) alignment 
Range on Protein: 322-378
Range on HMM: 72-128/165.0
LKYSRHMLCRGLKIVATQAHHPVLVHCFHGKDRTGLLVALVLSILKVPRESIIMDYH
 .   ..| . ||.. .....|||.|| .|| ||||... .  . | .  ||. .|.
veiksdllkkalklllnkenypvllhckrGkhrtglvigclRklqkWslasilnEyr
0043336 (Phosphotyrosine protein) phosphatases II 327-377 1.6e-09 33.1 In-house 193-252 (278) alignment 
Range on Protein: 327-377
Range on HMM: 193-252/278.0
HMLCRGLKIVAT---QAHHPVLVHCFHGKDRTGLLVALVL------SILKVPRESIIMDY
 .|.. ||.| .     ..|||||| .|..|||...|| |      ....|. |... ..
sllldflkavrealedsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkel
0049260 (Phosphotyrosine protein) phosphatases II 303-373 2.4e-09 32.5 In-house 56-121 (152) alignment 
Range on Protein: 303-373
Range on HMM: 56-121/152.0
NHMITKFNDMGLIGLNRIILKYSRHMLCRglkivATQAHHPVLVHCFHGKDRTGLLVALVLSILKVPRESI
... . . |.|   |  ..|   . . ..     | . ..||||||..|..|||.|||. | .|.|. | .
qylhlpwpDhgvpdlsqlllflllfiekl.....aldkggpvlVHCsaGvgRtgtlvaaylmllgvsleea
0048076 (Phosphotyrosine protein) phosphatases II 299-373 3.4e-09 32.1 In-house 45-114 (145) alignment 
Range on Protein: 299-373
Range on HMM: 45-114/145.0
EEAKNHMITKFNDMGLIGLNRIILKYSRHMlcrglkIVATQAHHPVLVHCFHGKDRTGLLVALVLSIL-KVPRESI
..  ... . . |.|   | ...|.  . .        | ....|||||| .|..|||.|||. | .| .|. |..
rlgiqylylpwpDhgvpdllellleflefi......eealkeggpvlVHCsaGvgRtgtlvaaylmlllgvsleea
0040439 (Phosphotyrosine protein) phosphatases II 338-377 4.5e-09 31.8 In-house 175-221 (249) alignment 
Range on Protein: 338-377
Range on HMM: 175-221/249.0
T-QAHHPVLVHCFHGKDRTGLLVALVLS------ILKVPRESIIMDY
.   ..|||||| .|..|||...|. |        |.|. |... ..
elpkggpvlVHCsaGvgRtGtfiaaylmleqlekelgvdleeavkll
0036282 (Phosphotyrosine protein) phosphatases II 303-366 4.9e-09 31.6 In-house 71-129 (174) alignment 
Range on Protein: 303-366
Range on HMM: 71-129/174.0
NHMITKFNDMGLIGLNRiILKYSRHMLCRGLKivatQAHHPVLVHCFHGKDRTGLLVALVLSIL
... . . |.|   |.  .|.  . .    ..      ..|||||| .|..|||.|||. | . 
qylylpwpDhgvpdlsi.llefvkfveealse....dpggpvlVHCsaGvgRtGtlvaaylmlr
0037934 (Phosphotyrosine protein) phosphatases II 330-377 6e-09 31.3 In-house 167-216 (243) alignment 
Range on Protein: 330-377
Range on HMM: 167-216/243.0
CRGLKIVATQAHHPVLVHCFHGKDRTGLLVALVLSIL--KVPRESIIMDY
 . | ..|   ..|||||| .|..|||.|.|. | .|  .|. |... ..
eellsllaldsggpvlVHCsaGvgRtGtliaaylmllllgvdleeavkll
0048179 (Phosphotyrosine protein) phosphatases II 303-368 6.9e-09 31.1 In-house 51-111 (144) alignment 
Range on Protein: 303-368
Range on HMM: 51-111/144.0
NHMITKFNDMGLIGLNRIILKYSRHMLCRglkivaTQAHHPVLVHCFHGKDRTGLLVALVLS-ILKV
... . . |.|   |  ..|.  . .          . ..|||||| .|..|||.|||. |   |..
qylhlpwpDhgvpdllellleflefieea......leeggpvlVHCsaGvgRtgtlvaaylmkklgl
0043147 (Phosphotyrosine protein) phosphatases II 303-371 1.1e-08 30.5 In-house 67-130 (172) alignment 
Range on Protein: 303-371
Range on HMM: 67-130/172.0
NHMITKFNDMGLIgLNRIILKYSRHMLCRGlkivATQAHHPVLVHCFHGKDRTGLLVALVLSILKVPRE
 .. . . |.|   | ...|.  . .  .     | . ..|||||| .|..|||.|||. | .|... |
qylylpwpDhgvp.llellleflefidell....alspggpvlVHCsaGvgRtgtlvaaylmllglsle
0039614 (Phosphotyrosine protein) phosphatases II 308-372 1.1e-08 30.4 In-house 192-259 (297) alignment 
Range on Protein: 308-372
Range on HMM: 192-259/297.0
KFNDMGLIGLNRIILKYSRHMLCRGLKIvatQAHHPVLVHCFHGKDRTGLLVALVLS------ILKVPRES
.. |.|   . ...|.  . .  .  .    . ..|||||| .|..||| ..|. |         .|  ..
gwpdhgvppslellleflelvrealael...pkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvle
0045450 (Phosphotyrosine protein) phosphatases II 336-373 1.1e-08 30.7 In-house 228-266 (307) alignment 
Range on Protein: 336-373
Range on HMM: 228-266/307.0
VATQ-AHHPVLVHCFHGKDRTGLLVALVLSILKVPRESI
...   ..|||||| .|..||| ..|. | .  . .| .
leelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegt
0044763 (Phosphotyrosine protein) phosphatases II 334-364 1.2e-08 30.3 In-house 103-133 (178) alignment 
Range on Protein: 334-364
Range on HMM: 103-133/178.0
KIVATQAHHPVLVHCFHGKDRTGLLVALVLS
. .  . ..|||||| .|..|.|.|||. | 
eealdekggpvlVHCsaGvgRsgtlvaaylm
0045098 (Phosphotyrosine protein) phosphatases II 304-367 1.5e-08 29.9 In-house 159-232 (278) alignment 
Range on Protein: 304-367
Range on HMM: 159-232/278.0
HMITKFNDMGLIGLN--RIILKYSRHMLCRGLKIVAT--------QAHHPVLVHCFHGKDRTGLLVALVLSILK
. .. . |.|   |.  . .|.. . .. .  ...          . ..|||||| .|..||| |||. | .  
lhylpwpdhgvpslpilksflellefirealkllaslllsslllldsggpvlVHCsaGvgRtGtlvaaylmlel
0038934 (Phosphotyrosine protein) phosphatases II 327-381 3.9e-08 28.7 In-house 97-167 (194) alignment 
Range on Protein: 327-381
Range on HMM: 97-167/194.0
HMLCRGLKIV----ATQAHHPVLVHCFHGKDRTGLLVALVLSI------------LKVPRESIIMDYHYSE
 .|.| |..|    . .... |.||| .|. |||.|||  |              ..  | ..|. ..| |
eillrfldlvdeflnedpggvvaVHCkaGlgRtGtlvaaYLiyrlgmsaeeAialfrekRpgaipnqdyle
0040438 (Phosphotyrosine protein) phosphatases II 336-368 3.9e-08 28.4 In-house 201-242 (317) alignment 
Range on Protein: 336-368
Range on HMM: 201-242/317.0
VAT---QAHHPVLVHCFHGKDRTGLLVALVLS------ILKV
| .   . ..|||||| .|..||| ..|. |         .|
vrealedpggpvlVHCsaGvgRtGtfiaaylmleqlekeggv
0046846 (Phosphotyrosine protein) phosphatases II 303-366 4.4e-08 28.6 In-house 78-134 (176) alignment 
Range on Protein: 303-366
Range on HMM: 78-134/176.0
NHMITKFNDMGLIGLnRIILKYSRHMLCrglkivATQAHHPVLVHCFHGKDRTGLLVALVLSIL
 .. . . |.|   | ...|.  . .        | ....||||||..|. |||.|||. | .|
qylhlpwpDhgvpdl.elllellefire......alkeggpvlVHCsaGigRtgtlvaayllel
subfamily_OCA_pd Subfamily OCA 15-72 7.5e-08 22.1 In-house 139-197 (282) alignment 
Range on Protein: 15-72
Range on HMM: 139-197/282.0
DPFATFVNFRDLSVLDT---RIKPHRFYRSATPSTLTSEdvvVLLEQLGVKTIIDLRDRS-E
 .....|..|..|....   ........|...|.... .   .|...||.||.. |.... |
prlyslvpprnfslveeykdkpvisgllrlllpeeenlp...fLidrlglktaliLdaeeve
PTPc_DSPc_SM00012 337-372 8.9e-08 27.7 In-house 38-70 (105) alignment 
Range on Protein: 337-372
Range on HMM: 38-70/105.0
AtqaHHPVLVHCFHGKDRTGLLVALVLSILKVPRES
    ..||.|||..| .||| .||| . . .. .|.
s...skpvvVhCsaGvgRtgtfvaldillqqleket
0036941 (Phosphotyrosine protein) phosphatases II 339-368 4.4e-07 25.0 In-house 205-234 (297) alignment 
Range on Protein: 339-368
Range on HMM: 205-234/297.0
QAHHPVLVHCFHGKDRTGLLVALVLSILKV
  ..|||||| .|. |.| ..|. | .  .
psggpvlVHCsaGvgRsgtfiaadlmlqql
0051299 (Phosphotyrosine protein) phosphatases II 321-368 4.8e-07 25.0 In-house 204-246 (288) alignment 
Range on Protein: 321-368
Range on HMM: 204-246/288.0
ILKYSRHMLCRGLkivatQAHHPVLVHCFHGKDRTGLLVALVLSILKV
.|.. |..          . ..||.||| .|..||| ..|| | .  .
lldflrlvrkala.....sgggpvvVHCsaGvgRtgtfialdllleql
0042113 (Phosphotyrosine protein) phosphatases II 15-75 5.2e-07 24.8 In-house 31-91 (245) alignment 
Range on Protein: 15-75
Range on HMM: 31-91/245.0
DPFATFVNFRDLSVLDTRIKPHRFYRSATPSTLTSEDVVVLLEQLGVKTIIDLRDRSEAEH
|..  ....   |  |.   ...|.... |.. | ||   .| .||..||..|..  | ..
dggdldsdyinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgr
0046845 (Phosphotyrosine protein) phosphatases II 338-372 5.2e-07 24.8 In-house 201-235 (284) alignment 
Range on Protein: 338-372
Range on HMM: 201-235/284.0
TQAHHPVLVHCFHGKDRTGLLVALVLSILKVPRES
.  ..|..||| .|. ||| ..|| | .  . .|.
lpgggpivVHCsaGvgRtGtfialdllleqlekeg
0047943 (Phosphotyrosine protein) phosphatases II 339-366 9e-07 24.1 In-house 203-230 (273) alignment 
Range on Protein: 339-366
Range on HMM: 203-230/273.0
QAHHPVLVHCFHGKDRTGLLVALVLSIL
  ..||.||| .|. ||| ..|| | . 
psngpvvVHCsaGvgRtgtfialdllld
0050432 (Phosphotyrosine protein) phosphatases II 337-367 1.1e-06 23.7 In-house 228-258 (308) alignment 
Range on Protein: 337-367
Range on HMM: 228-258/308.0
ATQAHHPVLVHCFHGKDRTGLLVALVLSILK
 .. ..|..||| .|  ||| ..|| | .  
kslpggpivVHCsaGvGRtGtfialdllleq
PTEN_1 340-367 7.8e-06 20.8 In-house 129-156 (196) alignment 
Range on Protein: 340-367
Range on HMM: 129-156/196.0
AHHPVLVHCFHGKDRTGLLVALVLSILK
 .. ||||| .|. |.|..||  |  ..
ngnvVlVHCkaGlgRsGtvvaayLmykg
Y_phosphatase Protein-tyrosine phosphatase 325-371 8.7e-06 20.7 Pfam-A 159-200 (235) alignment 
Range on Protein: 325-371
Range on HMM: 159-200/235.0
SRHMLCRGlkivaTQAHHPVLVHCFHGKDRTGLLVALVLSILKVPRE
 | .  .      .. ..||.||| .|  ||| .||| . . .. .|
irkveksk.....eaksgpvvVhCsaGvgRtgtfvaldilleqleae
Y_phosphatase Protein-tyrosine phosphatase 325-371 8.7e-06 20.7 In-house 159-200 (235) alignment 
Range on Protein: 325-371
Range on HMM: 159-200/235.0
SRHMLCRGlkivaTQAHHPVLVHCFHGKDRTGLLVALVLSILKVPRE
 | .  .      .. ..||.||| .|  ||| .||| . . .. .|
irkveksk.....eaksgpvvVhCsaGvgRtgtfvaldilleqleae