Gene expression:
Classification
Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.
Protein sequence
Domains
Summary
Details
| Domain | Domain Description | Range | Significance | Score | Source | Profile Range (length) | Alignment | ||
|---|---|---|---|---|---|---|---|---|---|
| 0051429 | (Phosphotyrosine protein) phosphatases II | 334-466 | 7.8e-29 | 96.6 | In-house | 126-272 (272) | alignment | ||
Range on Protein: 334-466
Range on HMM: 126-272/272.0
FYKVLMTRSY--AAICSVLQICADarNHPIMLHCSHGKDRTGVTTAVLLAALGVSDEAIAADYALSDDY--------------GNSPEGRQRFDTECPEL
.| .... |....|....| ..|.. |||.||||||. |.|| .||||.|.|..||.|.. | . |. .| |.
hytdwpdhgvpqeallellellld..ggpvlvHCsaGkdRTGtvvallllllgvsletivddYlltnlyleeaveelraqrpgavqteeqylflyealle
DPDEWARARPETMLQLMQWVREEFGGIDGYLDLIGFDGHWRHKLRQNLL
.... .|.|..|. .....||.|...||| .|.. .....||..||
llrsllsvraeyllaaldaideeyGsvegYLrdlglseeelerLrellL
|
|||||||||
| subfamily_OCA_pd | Subfamily OCA | 325-467 | 3e-21 | 66.0 | In-house | 146-278 (282) | alignment | ||
Range on Protein: 325-467
Range on HMM: 146-278/282.0
RFNKVGLLGFYKVlmtrsYAAICSVLQ-ICADARNHPIMLhcshgkDRTGVTTAVLLAALGVSDEAIAaDYalsddYGNSPEGRQRFDTECPELDPDEWA
......|. ||. ...|...|. .... .|.|... ||.|..||..|.| .|..|.|| |. . .| .. .....|. . |..
pprnfslveeykd.....kpvisgllrlllpeeenlpfLi......drlglktaliLdaeeveretia.df.....lasseiklvslrnevlkdlldndn
-------RARPETMLQLMQWvREEFGGIDGYLDLIGFDGHWRHKLRQNLLV
.|. .|.|..... ...| .. ||. |||.......|...||.
yavelscqaktdtvlkvLrk.dkkygstsiyleyigFtledqeslksilli
|
|||||||||
| Y_phosphatase3 | Tyrosine phosphatase family | 324-397 | 1.2e-19 | 65.9 | Pfam-A | 91-163 (164) | alignment | ||
Range on Protein: 324-397
Range on HMM: 91-163/164.0
RRFNKVGLLGFYKVLMTRSYAAICSVLQICADARnHPIMLHCSHGKDRTGVTTAVLLAALGVSDEAIAADYALS
.. .. . .|. ..... .|. .||...|... .|...||..|||||||..|.||..|||..|.|||||.|.
aeeaeeamaeayreiledekkayrkvlealaeee.gpvlfHCtaGKDRTGvvaalllsllgvdeetiaaDYllt
|
|||||||||
| 0051082 | (Phosphotyrosine protein) phosphatases II | 64-399 | 5.6e-19 | 63.7 | In-house | 2-133 (151) | alignment | ||
Range on Protein: 64-399
Range on HMM: 2-133/151.0
LETVANFRDICRVatlikpycIFRSSTPsqaTQKDAALLmEQVGIKTIIDFREQSESLrdcgacLLRE-----Qypefdlesqpgdkckeimrrmekipi
|... ||... ..||. | .. . .|| .. |||||...|. | . | .
lsdyinfsyvtgg........lyrsggp...ladflell.kelgiktivnlrseeerg......ycpeylpelg..........................
ttfaaqdirqatspsiprrpsaierdrerraraqqstssdsstepsrptfrldasvmvdevfdshdaastphatqtdkatptasqkepatgagdnntlda
....................................................................................................
edievvtlpgqrrlvrvpycprkvM-------------KkvvfgmlnnkdlgkvacwmflgglffrkkwrergksvakrrfnkvgllgfykvlMTRSYAA
. . . |..|
........................ievlhipildwpdpg......................................................lplsfda
ICSVLQICADARNHPIMLHCSHGKDRTGVTTAVLLAALGVSDEAIAADYALSDD
. ..|....| .|.|. |||.||.|||. |..| .|||| |.. ..| |.
vleflellldkkngpvlvHCsaGkgRTGtlvalylmllgvsleealeeyrlkrp
|
|||||||||
| Y_phosphatase3C | Tyrosine phosphatase family C-terminal region | 424-466 | 1.8e-11 | 33.5 | Pfam-A | 25-68 (68) | alignment | ||
Range on Protein: 424-466
Range on HMM: 25-68/68.0
RARPETMLQLMQWVREEFGGIDGYL-DLIGFDGHWRHKLRQNLL
.|.|.. . .....|..|...||| . .|.. . . .||..||
gvreeyleaaldtideryGsvegYLeeaLGlseedierLRerlL
|
|||||||||
| 0049772 | (Phosphotyrosine protein) phosphatases II | 343-396 | 6.8e-11 | 37.9 | In-house | 196-252 (314) | alignment | ||
Range on Protein: 343-396
Range on HMM: 196-252/314.0
YAAICSVLQICAD-ARNHPIMLHCSHGKDRTG--VTTAVLLAALGVSDEAIAADYAL
. . ..|... . ...|. ||..||.||| |..| |. .|||| | . .|. |
ledfdeflefieeadkggpvlvHCkaGkgRtgtfvvaaylmkllgvsleealedvrl
|
|||||||||
| 0051429 | (Phosphotyrosine protein) phosphatases II | 63-126 | 6.1e-10 | 34.7 | In-house | 2-64 (272) | alignment | ||
Range on Protein: 63-126
Range on HMM: 2-64/272.0
HLETVANFRDICRVATLIKPYCIFRSSTPSQATQKDAALLmEQVGIKTIIDFREQSESLRDCGA
.|... |.||. .|| ..||. |...|..| . | .. |||||.|.|. .| |.
plsgyiNardvggygrvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcd
|
|||||||||
| Y_phosphatase3 | Tyrosine phosphatase family | 69-153 | 2.2e-09 | 32.5 | Pfam-A | 1-88 (164) | alignment | ||
Range on Protein: 69-153
Range on HMM: 1-88/164.0
NFRDICRVAT----LIKPYCIFRSSTPSQATQKDAALLMeQVGIKTIIDFREQSESLRDCGACLLREQYPEFDLESQPGDKCKEIMRRM
||||. ..| ..| ..||.. |..|..|.| | ..||||..|.|...| .. .| ....... .. .|. .|.
NfRDlGgyptadgrtvrpgvlyRSaalsklteadlaaLa.elgiktvvDLRseeEvekepdklpegvkyvnlpvlkeeaespeelaerl
|
|||||||||
| 0042113 | (Phosphotyrosine protein) phosphatases II | 345-394 | 2.2e-09 | 32.6 | In-house | 163-218 (245) | alignment | ||
Range on Protein: 345-394
Range on HMM: 163-218/245.0
AICSVLQICADARNHPIMLHCSHGKDRTGVTTAVLL------AALGVSDEAIAADY
.. |....|. .|.|.. |||.|..|||. |..| . |||| | . ...
flefvrkalaedsngpvlVHCsaGvgRtGtfiaaylmleqlekelgvsleeavkel
|
|||||||||
| 0044763 | (Phosphotyrosine protein) phosphatases II | 76-386 | 2.7e-08 | 29.2 | In-house | 22-139 (178) | alignment | ||
Range on Protein: 76-386
Range on HMM: 22-139/178.0
VATLIKPYcIFRSSTPSqatqKDAALLMEQVGIKTIIDFREQSESLRdcgacllreQ----------Ypefdlesqpgdkckeimrrmekipittfaaqd
|. | |. ....| |. | |. . ||..|....| | . .
naseilpg.lylgslpp....addlellkelgithivnlteelelgf.........lkcdpywpeeag................................
irqatspsiprrpsaierdrerraraqqstssdsstepsrptfrldasvmvdevfdshdaastphatqtdkatptasqkepatgagdnntldaedievvt
....................................................................................................
lpgqrrlvrvpycprkvmkkvvfgmlnnkdlgkvacwmflgglffrkkwrergksvakRRFNKVGLLGFYKVLMTRSYAAICSVLQICADARNHPIMLHC
.. .... .. ... ... .. . | ...|. ||
..........................................................iqylhipipDhgvpdllehflefvefieealdekggpvlVHC
SHGKDRTGVTTAV-LLAALGVS
|.|..|.|. | |. ||.|
saGvgRsgtlvaaylmkklgls
|
|||||||||
| 0036282 | (Phosphotyrosine protein) phosphatases II | 324-385 | 3.5e-08 | 28.8 | In-house | 70-131 (174) | alignment | ||
Range on Protein: 324-385
Range on HMM: 70-131/174.0
RRFNKVGLLGFYKVLMTRSYAAICSVLQICADARNHPIMLHCSHGKDRTGVTTAVLLAALGV
.. ... .. .. . ... | ..... ...|. |||.|..|||. | .| |
iqylylpwpDhgvpdlsillefvkfveealsedpggpvlVHCsaGvgRtGtlvaaylmlrgl
|
|||||||||
| 0043336 | (Phosphotyrosine protein) phosphatases II | 346-394 | 6.3e-08 | 27.9 | In-house | 199-252 (278) | alignment | ||
Range on Protein: 346-394
Range on HMM: 199-252/278.0
ICSVLQICAdARNHPIMLHCSHGKDRTGVTTAVLLA------ALGVSDEAIAADY
. |..... .|.|.. |||.|..|||. |..|. .||. | . ...
lkavreale.dsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkel
|
|||||||||
| 0040439 | (Phosphotyrosine protein) phosphatases II | 346-394 | 6.4e-08 | 28.0 | In-house | 166-221 (249) | alignment | ||
Range on Protein: 346-394
Range on HMM: 166-221/249.0
ICSVLQICADA-RNHPIMLHCSHGKDRTGVTTAVLLA------ALGVSDEAIAADY
| |....... ...|.. |||.|..|||. | .|. |||. | . ...
ieavrkaleelpkggpvlVHCsaGvgRtGtfiaaylmleqlekelgvdleeavkll
|
|||||||||
| Y_phosphatase2 | Tyrosine phosphatase family | 339-379 | 1.4e-07 | 23.4 | Pfam-A | 72-112 (165) | alignment | ||
Range on Protein: 339-379
Range on HMM: 72-112/165.0
MTRSYAAICSVLQICADARNHPIMLHCSHGKDRTGVTTAVL
. . . .|.. . .|.|..|||..|| |||. ..|
veiksdllkkalklllnkenypvllhckrGkhrtglvigcl
|
|||||||||
| 0037934 | (Phosphotyrosine protein) phosphatases II | 349-394 | 3.2e-07 | 25.6 | In-house | 169-216 (243) | alignment | ||
Range on Protein: 349-394
Range on HMM: 169-216/243.0
VLQICADARNHPIMLHCSHGKDRTGVTTAVLLAAL--GVSDEAIAADY
.|.. |. ...|. .|||.|..|||. | .| | ||. | . ...
llsllaldsggpvlVHCsaGvgRtGtliaaylmllllgvdleeavkll
|
|||||||||
| 0049260 | (Phosphotyrosine protein) phosphatases II | 345-388 | 5e-07 | 25.0 | In-house | 76-119 (152) | alignment | ||
Range on Protein: 345-388
Range on HMM: 76-119/152.0
AICSVLQICADARNHPIMLHCSHGKDRTGVTTAVLLAALGVSDE
.. .....| ...|. |||.|..|||. | .| |||| |
flllfieklaldkggpvlVHCsaGvgRtgtlvaaylmllgvsle
|
|||||||||
| 0045450 | (Phosphotyrosine protein) phosphatases II | 345-388 | 8.3e-07 | 24.5 | In-house | 220-264 (307) | alignment | ||
Range on Protein: 345-388
Range on HMM: 220-264/307.0
AICSVLQICADA-RNHPIMLHCSHGKDRTGVTTAVLLAALGVSDE
| |...... ...|.. |||.|..|||. | .|. .. .|
fieevrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqleke
|
|||||||||
| 0048076 | (Phosphotyrosine protein) phosphatases II | 347-390 | 9.1e-07 | 24.2 | In-house | 68-114 (145) | alignment | ||
Range on Protein: 347-390
Range on HMM: 68-114/145.0
CSVLQIC--ADARNHPIMLHCSHGKDRTGVTTAV-LLAALGVSDEAI
...|... | ....|. |||.|..|||. | |. |||| | .
leflefieealkeggpvlVHCsaGvgRtgtlvaaylmlllgvsleea
|
|||||||||
| PTPc_DSPc_SM00012 | 345-388 | 1.3e-06 | 23.9 | In-house | 21-69 (105) | alignment | |||
Range on Protein: 345-388
Range on HMM: 21-69/105.0
AICSVLQICADARN-----HPIMLHCSHGKDRTGVTTAVLLAALGVSDE
.|...|. . . .| .|...|||.| .|||. .|. .. ...|
silellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleke
|
|||||||||
| 0048179 | (Phosphotyrosine protein) phosphatases II | 346-388 | 1.3e-06 | 23.7 | In-house | 69-114 (144) | alignment | ||
Range on Protein: 346-388
Range on HMM: 69-114/144.0
ICSVLQICADA--RNHPIMLHCSHGKDRTGVTTAV-LLAALGVSDE
....|... .| ...|. |||.|..|||. | |. ||.| |
lleflefieealeeggpvlVHCsaGvgRtgtlvaaylmkklglsle
|
|||||||||
| 0039614 | (Phosphotyrosine protein) phosphatases II | 346-386 | 1.5e-06 | 23.4 | In-house | 209-256 (297) | alignment | ||
Range on Protein: 346-386
Range on HMM: 209-256/297.0
ICSVLQICADA-RNHPIMLHCSHGKDRTGVTTAVLLA------ALGVS
. | ...| . ...|. |||.|..|||. | .|. ||.
lelvrealaelpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvd
|
|||||||||
| 0040438 | (Phosphotyrosine protein) phosphatases II | 348-381 | 1.9e-06 | 22.8 | In-house | 199-232 (317) | alignment | ||
Range on Protein: 348-381
Range on HMM: 199-232/317.0
SVLQICADARNHPIMLHCSHGKDRTGVTTAVLLA
. .. . . ...|.. |||.|..|||. |..|.
eavrealedpggpvlVHCsaGvgRtGtfiaaylm
|
|||||||||
| 0041856 | (Phosphotyrosine protein) phosphatases II | 345-386 | 2.8e-06 | 22.6 | In-house | 97-138 (182) | alignment | ||
Range on Protein: 345-386
Range on HMM: 97-138/182.0
AICSVLQICADaRNHPIMLHCSHGKDRTGVTTAV-LLAALGVS
... .... . ...|. |||.|..|||. | |. ||||
elldfieevle.eggpvlVHCsaGvgRtgtlvaaylmkklgvs
|
|||||||||
| 0043147 | (Phosphotyrosine protein) phosphatases II | 345-386 | 3.8e-06 | 22.2 | In-house | 87-128 (172) | alignment | ||
Range on Protein: 345-386
Range on HMM: 87-128/172.0
AICSVLQICADARNHPIMLHCSHGKDRTGVTTAVLLAALGVS
.. . ...| ...|. |||.|..|||. | .| ||.|
flefidellalspggpvlVHCsaGvgRtgtlvaaylmllgls
|
|||||||||
| subfamily_OCA_pd | Subfamily OCA | 61-118 | 6.2e-06 | 15.8 | In-house | 138-195 (282) | alignment | ||
Range on Protein: 61-118
Range on HMM: 138-195/282.0
TAHLETVANFRDICRVAT---LIKPYCIFRSSTPSQATQKdaaLLMEQVGIKTIIDFREQS
...|... ..|... |.. .......|...|.... . .|....|.||.. . ..
fprlyslvpprnfslveeykdkpvisgllrlllpeeenlp...fLidrlglktaliLdaee
|
|||||||||
| 0045098 | (Phosphotyrosine protein) phosphatases II | 348-385 | 7.8e-06 | 21.0 | In-house | 187-233 (278) | alignment | ||
Range on Protein: 348-385
Range on HMM: 187-233/278.0
SVLQICA---------DARNHPIMLHCSHGKDRTGVTTAVLLAALGV
..|. | . ...|. |||.|..|||. |. | .
ealkllaslllsslllldsggpvlVHCsaGvgRtGtlvaaylmlell
|
|||||||||