Gene MbrePTP-sf1-1 in Monosiga brevicollis

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily MbrePTP-sf1
Protein sequence
ID Type Fasta BLAST phosphatome Note
MbreP032_AA protein Get Run
MbreP032_AA_651-950 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 655-953 5e-126 414.5 In-house 1-280 (281) alignment 
Range on Protein: 655-953
Range on HMM: 1-280/281.0
ALRQHFQDLQRND--GLQSEFATIEAADVRNTSVAAKRDANTHKHRYSNIFAYDHTRVRVTPDDAALrsdpapngdlttdegldviNTDYIDANFIAGVS
|||.|...|..||  |...|.....|..|.||..|.|.|.|..|.|||||.|||.|||.|||....                    |||||.|||..|..
alrkhlkqlsqndnaGfieeyeklaaigvdntataskadenvlknrYsnivaYDatrvkvtpneenk...................ntDYinanfvpgyk

GKAEYIVTEAPIPATMNIFWRMVFEQGVSAIVVLTRELEAGRLRCHRYWPEEGQSTIYADITVTTTAWREQPRSARRTLRLERPGCEPRRIEQLLFTAWP
|..|||.|..|.||....||.||.|| |||||..|||.|||.|.||||||.. ....|.|.||..||..|......|...||| ..|.|..||| .||||
gekeyiatqgPvPaslvafWqmvweqkvsaivmvtreieagklkChrYWPddnselkygdvtvkstaeeekatyierkfkleresgetreveqlaytaWP

ETGVPADPNAFLDFHREVQQCTRPNGNltAPMVVHCSSGVGRSGCFVAFDRLAQSAARQLTPLSVKATILSLRHERMLMVQTVLQYEFVYKAVLRYLDLE
..||||.....|.|..||...|... .  ||.|.|||.||||.|...|.|||.......|..|.|||.. .||.||.||||||.||||||||||..|| |
dhGvPattkellefrkevlkltekktk..aplvihCsaGvGrtGtyialDrlvkaveaeleeldvkavvaelrkernlmvqtvvqyefvykavldaldke

L
|
l
0050432 (Phosphotyrosine protein) phosphatases II 639-952 7.8e-77 253.9 In-house 14-302 (308) alignment 
Range on Protein: 639-952
Range on HMM: 14-302/308.0
PRSSQPHHEYLELQQNALRQHFQDLQRNDGLQSEFATIEAADVRNTSVAAKRDANTHKHRYSNIFAYDHTRVRVtPDDaalrsdpapngdlttdegldvi
 |. . ....|.|    | ......  . .|. || .. .  . ..  .|.. .| .|.||..|..|||.||.. ...                      
frdtsilvsslklsvldllkllekaldlglleeefeellsvkplleysvallpenkdkNrykdilpydhsRVkl.deg......................

nTDYIDANFIAGV--SGKAEYIVTEAPIPATMNIFWRMVFEQGVSAIVVLTRELEAGRLRCHRYWPEE--GQSTIYADITVTTTAWREQPRSARRTLRLE
 .|||.|... |     . ..|.| .| | |.. |||||.||.|. ||.||.. | ||  |..|||.|  |.|..| ..|||..   ...   .|||.|.
.sdYInAsyvdgyssklprkfIatqgPlpntvedFwrmvweqnvrvIvmLtklvengrekcaqYwplelgggsleygkftvtllseevlddytvrtlelt

R-PGCEPRRIEQLLFTAWPETGVPADPNAFLDFHREVQQCTrPNgnltAPMVVHCSSGVGRSGCFVAFDRLAQSAARQlTPLSVKATILSLRHERMLMVQ
   . | |.. .. .|.||. ||| .|...||| ..|...  |.     |.||||| ||||.|.|.| | | .   ..   ..|  ..  ||. |. |||
nlgdgesrtvthfhytnWpdhgvPpspeilldflelvrksl.pg....gpivVHCsaGvGRtGtfialdllleqleke.ggvdvfeavkklReqRpgmvq

TVLQYEFVYKAVLRYLDLE
|. ||.|.|.|.| || | 
tpeqylflyralleylklk
subfamily_PTPRD_pd Subfamily PTPRD 653-951 1.2e-75 250.2 In-house 7-283 (564) alignment 
Range on Protein: 653-951
Range on HMM: 7-283/564.0
QNALRQHFQDLQRNDG--LQSEFATIEAAdVRNTSVAAKRDANTHKHRYSNIFAYDHTRVRVTPddaalrsdpapngdLTTDEGldvinTDYIDANFIAG
 ..|..|.. |. |..  ...|. .||    . |  ||. .|| .| ||.|| ||||.||. ..              .  |||     .||| |.|| |
vaelkehvaklkansdlkfeeeykkieeg.qqftweaankpaNkaKNRyanivaYdhsRVvLsk..............vegdeg.....sDYINAsfidg

VSGKAEYIVTEAPIPATMNIFWRMVFEQGVSAIVVLTRELEAGRLRCHRYWPEEGqSTIYADITVTTTAWREQPRSARRTLRLERPG-CEPRRIEQLLFT
   . .|| | .|.. |.. |||||.|| .| || ||.  | |. .||.||||.| .. | ..||| ..  |      ||..|..    | | ..|  ||
yrkrkayIAtqgPlaetiedFWRmvweqnsstiVmltkleEkgkvkchkYWPekg.tetygeltVtleeeeeladyeirtfklkkkkssesreVrqFhFt

AWPETGVPADPNAFLDFHREVQQCTRpngNLTAPMVVHCSSGVGRSGCFVAFDRLAQSAARqLTPLSVKATILSLRHERMLMVQTVLQYEFVYKAVLRYL
.||..|||  ....||. |.|.....   . . |.|||||.||||.|.|.. | . . .      . .  ..  ||..|  ||||  || |...|.| .|
sWPdhgvpesatslLdlirkvralne...pdagPivVhCSaGVGRTGtfividamlerike.ektvDiyqyvkalrkqRnamVqteeQYiFiheaileal

DL
. 
ac
0051299 (Phosphotyrosine protein) phosphatases II 663-949 8.2e-75 247.2 In-house 19-286 (288) alignment 
Range on Protein: 663-949
Range on HMM: 19-286/288.0
LQRNDGLQSEFATIEAADVRNTSVAAKRDANTHKHRYSNIFAYDHTRVRVTpddaalrsdpapngdlttdE--GldVINTDYIDANFIAGVSGKAEYIVT
.  . ||. || .. .  . .|  ||.. .| .|.|||.|..|||.||...                      |  | ..|||.|..| |   | ..|.|
angltglleefeellsllpdltlsaallpenleknRysdilpydhsRVkLs...................vldg..vegsdYinAsyidgynlkrkfIat

EAPIPATMNIFWRMVFEQGVSAIVVLTRELEAGRLRCHRYWPEeGQSTIYADITVTTTAWREQPRSARRTLRLER-----PGCEPRRIEQLLFTAWPETG
..| | |.. |||||.||.|. ||.||.. | ||  |..|||. |.|..| |||||..   ...    |||....     .. |.|.. .. .|.||. |
qgPlpntvedFWrmvweqnvrvIvmltklvelgrekcaqYwpl.ggsltygditvtllseevlddytvrtlevtnldlldgdgesrtvthfhytnwpdhg

VPADPNAFLDFHREVQQCTRpngNLTAPMVVHCSSGVGRSGCFVAFDRLAQSAARQlTPLSVKATILSLRHERMLMVQTVLQYEFVYKAVLRYL
|| .|...||| |.|... .   .   |.||||| ||||.|.|.| | | .   ..   ..|  ..  ||. |. ||||. ||.|||.|.| ||
vpdspellldflrlvrkala...sgggpvvVHCsaGvgRtgtfialdllleqleke.ggvdvleavkrlreqRpgmvqtpeqyrfvyealleyl
DSPc_SM00195 669-949 1.3e-72 239.7 In-house 2-262 (263) alignment 
Range on Protein: 669-949
Range on HMM: 2-262/263.0
LQSEFATIEAADVRNTSVAAKRDANTHKHRYSNIFAYDHTRVRVTPDDAAlrsdpapngdlttdegldvINTDYIDANFIAGVSGKAEYIVTEAPIPATM
|. || ..|...  ...  |....|..|.||.||. ||||||......                      ..||| ||.| | . | .||.| .| | |.
lkeefekleestspketteaekkknksknRyknilpydhtrVklkkeekk...................egsdYINAnyikgankkkkyIatQgPlpstv

NIFWRMVFEQGVSAIVVLTRELEAGRLRCHRYWPEE-GQSTIYADITVTTTAWREQP-RSARRTLRLERPGC-EPRRIEQLLFTAWPETGVPADPNAFLD
. |||||.|..|. ||.||.| | |. .|.|||||| |... . .|.|...   ...    .|||.|.  |. |.|...|. ...||. ||| ... .|.
edFWrmvweekvkiivmlteeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvle

FHREVQQCTRPNgnlTAPMVVHCSSGVGRSGCFVAFDRLAQSAARQLTpLSVKATILSLRHERMLMVQTVLQYEFVYKAVLRYL
. |.|..... .   ..|.||||| ||||.|.||. | . .. ... . ....... .||..|. ||||  || |.|.|.|.|.
llravkksksts...sgpivVhCsaGvgRtgtfvtidiilskleeekk.vdifeivkelRkqRpgmvqtleqYlfiyeaileyi
PTPc_SM00194 669-949 1.3e-72 239.7 In-house 2-262 (263) alignment 
Range on Protein: 669-949
Range on HMM: 2-262/263.0
LQSEFATIEAADVRNTSVAAKRDANTHKHRYSNIFAYDHTRVRVTPDDAAlrsdpapngdlttdegldvINTDYIDANFIAGVSGKAEYIVTEAPIPATM
|. || ..|...  ...  |....|..|.||.||. ||||||......                      ..||| ||.| | . | .||.| .| | |.
lkeefekleestspketteaekkknksknRyknilpydhtrVklkkeekk...................egsdYINAnyikgankkkkyIatQgPlpstv

NIFWRMVFEQGVSAIVVLTRELEAGRLRCHRYWPEE-GQSTIYADITVTTTAWREQP-RSARRTLRLERPGC-EPRRIEQLLFTAWPETGVPADPNAFLD
. |||||.|..|. ||.||.| | |. .|.|||||| |... . .|.|...   ...    .|||.|.  |. |.|...|. ...||. ||| ... .|.
edFWrmvweekvkiivmlteeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvle

FHREVQQCTRPNgnlTAPMVVHCSSGVGRSGCFVAFDRLAQSAARQLTpLSVKATILSLRHERMLMVQTVLQYEFVYKAVLRYL
. |.|..... .   ..|.||||| ||||.|.||. | . .. ... . ....... .||..|. ||||  || |.|.|.|.|.
llravkksksts...sgpivVhCsaGvgRtgtfvtidiilskleeekk.vdifeivkelRkqRpgmvqtleqYlfiyeaileyi
0046845 (Phosphotyrosine protein) phosphatases II 668-952 3.3e-72 238.6 In-house 1-277 (284) alignment 
Range on Protein: 668-952
Range on HMM: 1-277/284.0
GLQSEFATIEAADVRN--TSVAAKRDANTHKHRYSNIFAYDHTRVRVTPDDAALRS-DpapngdlttdegldvintdYIDANFIAGV-----SGKAEYIV
||. || ..    |    .  .|.. .| .|.||..|..|||.||.... |  | . |                   ||.|... |        | ..|.
gleeefeellsltvklllslsvallpenlsknRykdilpydhsRVklksldgdledsd...................YinAsyvdgydldltyikkkfIa

TEAPIPATMNIFWRMVFEQGVSAIVVLTRELEAGRLRCHRYWPEEGQSTIYADITVTTTAWREQPRSARRTLRLERP--GCEPRRIEQLLFTAWPETGVP
| .| | |.. |||||.||.|. ||.||.. | ||  |..|||.||.. .| |.|||..   ...   .|||.|..   . |.|.. .. .|.||. |||
tqgPlpntvedFwrmvweqnvrvIVmltelvengrekcaqYwplegevltygdftvtllseevkddytvrtleltnlgytgesrtvthfhytswpdhgvp

ADPNAFLDFHREVQQCTRPnGNLTAPMVVHCSSGVGRSGCFVAFDRLAQSAARQLT--PLSVKATILSLRHERMLMVQTVLQYEFVYKAVLRYLDLE
..|. .|.| |.|... .   .   |.||||| ||||.|.|.| | | .   .. .   ..|  ..  ||  |. ||||. ||.|||.|.| || | 
pspedlleflrlvrellen.lpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyealleylklk
subfamily_PTPRB_pd Subfamily PTPRB 651-951 3.6e-72 237.9 In-house 7-287 (293) alignment 
Range on Protein: 651-951
Range on HMM: 7-287/293.0
LQQNALRQHFQDLQR--NDGLQSEFATIEAADVRNTSVAAKRDANTHKHRYSNIFAYDHTRVRVTPDDaalrsdpapngdlttdeglDVINTDYIDANFI
.. . . .|......  . ... |. ...| .  .. .||.. .|. | ||.|| .|||.||.... .                   |  ..|||.||.|
iklekfeehvkkmkadsdlrfseeyeelkavgkdqavkaaelavnraknrytnilpydhsrvkLaalk...................desgsDYinanyi

AGVSGKAEYIVTEAPIPATMNIFWRMVFEQGVSAIVVLTRELEAGRLRCHRYWPEEGQSTIYADITVTTTAWREQPRSARRTLRLERpGCEPRRIEQLLF
 | . . |.|.|  |.| |.. |||||.|. .|.||.||. .| |. .|..|||.. ....| ||.|| .| .|.   . |.|..|. . | |...|. |
pgynsprefiatqGPlpetvddfWrmvwekkssiivmltqlvekgkvkCeeYWPadeepvlyGdikvtlvaeeeledwvirelkiek.ekeerkvrqyhf

TAWPETGVPADPNAFLDFHREVQQCTRpNGNLTAPMVVHCSSGVGRSGCFVAFDRLAQSAARqLTPLSVKATILSLRHERMLMVQTVLQYEFVYKAVLRY
|.||. ||| .....||| |.|.. .. . . ..|.|||||.||||.| |.| ||| |.  .    . . ... .||.||.|.|||. || |....||..
tsWpdhgvPektktlldfvrtvreaie.ktaskrPivvhCsaGvGRtGtfialdrllqaiee.edyvdifgivaelReeRnllvqtekqYifihqcvldl

LDL
|  
lrk
0036941 (Phosphotyrosine protein) phosphatases II 663-949 7e-72 237.5 In-house 9-277 (297) alignment 
Range on Protein: 663-949
Range on HMM: 9-277/297.0
LQRNDGLQSEFATIEAADVRNTSVAAKRDANTHKHRYSNIFAYDHTRVRVTPDDaalrsdpapngdlttdegldvinTDYIDANFIAGVSGKAEYIVTEA
|  . .|..|| ..    .  .  .|.. .| .|.||..|..||||||......                       .|||.|... | . | ..|.|..
llflalllkefeellpllllgslsvallpenleknRykdilpydhtRVklddeg.......................sdYinAsyvdgydlkrkfIatqg

PIPATMNIFWRMVFEQGVSAIVVLTRELEAGRLRCHRYWPEE-GQSTIYADITVTTTAWRE--QPRSARRTLRLER-PGCEPRRIEQLLFTAWPETGVPA
| | |.. |||||.||.|. ||.||.. | ||  |..|||.| |.|  | |.|||..   .   .   .|||...   . |.|.. .. .| ||. ||| 
PlpntvedFWrmvweqnvtvIvmltelvelgrekcaqywpleegesltygdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpe

DPNAFLDFHREVQQCTRPN--GnltAPMVVHCSSGVGRSGCFVAFDRLAQSAAR--QLTPLSVKATILSLRHERMLMVQTVLQYEFVYKAVLRYL
.|. .||| ..|... .    |    |..|||| ||||||.|.| | . |   .      .... ....||. |. .|||. ||.|.| |.| .|
spaslldfielvrkvlkllpsg...gpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallell
0040438 (Phosphotyrosine protein) phosphatases II 666-949 4.1e-71 235.2 In-house 17-276 (317) alignment 
Range on Protein: 666-949
Range on HMM: 17-276/317.0
NDGLQSEFATIEAADVRnTSVAAKRDANTHKHRYSNIFAYDHTRVRVTPddaalrsdpapngdlttDEGldVINTDYIDANFIAGVSGKAEYIVTEAPIP
. .|..|| ..   ..  |   |.. .| .|.||..|. |||.||...|                 ..|  . ..||| |... | . | ..|.| .| |
ftalleefedllslkld.tysvaelpenkdknrypdilpydhsRVkLsp.................lgg..dldsdYInAsyvdgpnlkrkfIatqgPlp

ATMNIFWRMVFEQGVSAIVVLTRELEAGRLRCHRYWPEeGQSTIYADITVTTTAWREQPRSARRTLRLER-PGCEPRRIEQLLFTAWPETGVPADPNAFL
 |.. |||||.||||. || ||.. | ||  |..|||. |... | |.|||..   | .    |||..|   . |.|.. .. .|.||. ||| .|. .|
ntvedFwrmvweqgvtvivmLteleelgrekcaqYwpl.getltygdftvtllseeelagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdlll

DFHREVQQCTRpngNLTAPMVVHCSSGVGRSGCFVAFDRLAQSAARQLtPLSVKATILSLRHERMLMVQTVLQYEFVYKAVLRYL
|| ..|... .   .   |..|||| ||||.|.|.| ... .   .    ..|. ..  ||. |. .|||  ||.|.|.|.| ||
dfleavreale...dpggpvlVHCsaGvgRtGtfiaaylmleqlekeg.gvdveeavkelreqRpgavqtpeqyrflydalleyl
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 651-951 2.1e-69 229.0 In-house 2-282 (318) alignment 
Range on Protein: 651-951
Range on HMM: 2-282/318.0
LQQNALRQHFQDLQRND--GLQSEFATIEAADVRNTSVAAKRDANTHKHRYSNIFAYDHTRVRVTPDDaalrsdpapngdlttdeglDVINTDYIDANFI
.. ..|..| . |...    |..|.  ..  .   ||. .  ..| .| || || |||||||.... .                   .. ..|||.||.|
isvedleshvrrlresGelllseeyerlsrseetvtslkslepvnkaknryanilaydhtrvkLqmle...................geegsDyinanyi

AGVSGKAEYIVTEAPIPATMNIFWRMVFEQGVSAIVVLTRELEAGRLRCHRYWPEEGqSTIYADITVTTTAWREQPRSARRTLRLERPGCE-PRRIEQLL
 |   | .|| . ||.| |.. |||||.||. . ||.||.| |.|. ..|||||..| |. | ...|. .   |      |.....| ..|  | . |  
dGyrrkkayiaaqaPlpetieDfWrmvWeqnsavivmltqeeergkakvhryWPskg.srsygklvvelkeevelsdyvlrefkvtrteeeesrqvrqyh

FTAWPETGVPADPNAFLDFHREVQQCTRPNGNltAPMVVHCSSGVGRSGCFVAFDRLAQSAARQLTpLSVKATILSLRHERMLMVQTVLQYEFVYKAVLR
.|.||..|||...  .||. |.|..  ...|.   |.|||||.|||| | |.| | | . .. . . . |  |.  ||..| |||||  ||||.|...| 
ytsWpdegvpesgaslldlvrqvskaqqksga..gpivvhCsaGvGrtGvfiavdillerikaeal.vDvfqtvkqlreqrnlmvqtedqyefiydvlle

YLDL
.|  
alas
0047943 (Phosphotyrosine protein) phosphatases II 659-949 9.5e-69 227.2 In-house 4-272 (273) alignment 
Range on Protein: 659-949
Range on HMM: 4-272/273.0
HFQDLQRNDGLQSEFATIEAADVRNTSVAAKRDANTHKHRYSNIFAYDHTRVRVtpddaalrsdpapngdlttdeglDVINTDYIDANFIAGVSGKAEYI
....|  ...|. || ..    .  |  .|.. .| .|.||..|..|||.||..                       .  ..||| |... |   | ..|
llekllgltllleefelllslkplltysvallpenkdknrykdilpydhsrvkl.......................gdggsdyinAsyvdgynlkrkfi

VTEAPIPATMNIFWRMVFEQGVSAIVVLTRELEAGRLRCHRYWPEEGQ--STIYADITVTTTAWREQPRSARRTLRLER-PGCEPRRIEQLLFTAWPETG
.|..| | |.. |||||.||.|. ||.||.. | ||  |..|||.||.  |..| ..|||..   . .    |||.|..    |.| . ....| ||. |
atqgPlpntvedfwrmvweqnvrviVmLtelvelgrekcaqYwpleggelsltygkftvtllseetkddytvrtleltnlgtgesrtvthfhytgwpdhg

VPADPNAFLDFHREVQQCTRP---NgnltAPMVVHCSSGVGRSGCFVAFDRLAQSAARQlTPLSVKATILSLRHERMLMVQTVLQYEFVYKAVLRYL
||.... .|.| ..|... .    |     |.||||| ||||.|.|.| | | .   .    ..|. ..  ||  |. ||||. ||.|.|.|.| ||
vppslesllefielvrkalealpsn....gpvvVHCsaGvgRtgtfialdllldqleke.ggvdvleavkllrsqRpgmvqtpeqyrflyealleyl
0045450 (Phosphotyrosine protein) phosphatases II 656-949 1.6e-68 227.0 In-house 16-304 (307) alignment 
Range on Protein: 656-949
Range on HMM: 16-304/307.0
LRQHFQDLQRNDGLQSEFATIEAADV--RNTSVAAKRDANTHKHRYSNIFAYDHTRVRVTPDDaalrsdpapngdlT-----TdegldvintdYIDANFI
| .. . |  . ||. || ..    |   ..  .|.. .| .|.||..|..||||||.... |                              ||.|...
llvllllldfltgllkefekllsvtvfllgeysiallpenkdknrykdilpydhtRVklssld.............gsledsd..........YiNAsyv

--------AGVSGKAEYIVTEAPIPATMNIFWRMVFEQGVSAIVVLTRELEAGRLRCHRYWPEEGQSTIYADITVTTTAWREQPRSARRTLRLER--PGC
         |   | ..|.| .| | |.. ||||..||||..|| ||.. | ||  |..|||.||..  | ..|||..   ...   .|||....  .  
rvpllllldgydlkrkfIatqgPlpetvedFwrmlweqgvtvivmltelvelgrekcaqywPdegeeltygnftvtllseehldgytvrtlevtdldgtg

EPRRIEQLLFTAWPETGVPADPNAFLDFHREVQQCTRPNgNLTAPMVVHCSSGVGRSGCFVAFDRLAQSAARQLTP--LSVKATILSLRHERMLMVQTVL
|.|.. .. .|.||..||| ... .||| .||... . . .   |..|||| ||||.|.|.| . . .   .. |   ...  ..  ||  |. .||.  
esrtvthfhytgwpdhgvppsfeelldfieevrkaleel.pkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpe

QYEFVYKAVLRYL
||.|.|.|.| .|
qyrflyeallell
0039614 (Phosphotyrosine protein) phosphatases II 657-950 1e-67 224.1 In-house 22-290 (297) alignment 
Range on Protein: 657-950
Range on HMM: 22-290/297.0
RQHFQDLQRNDGLQSEFATIEAADVrNtSVAAKRDANTHKHRYSNIFAYDHTRVRVTPDDaalrsdpapngdlttdeglDV-INTDYIDANFIAGVSG-K
 ... ..  . .|. || ..    . .  . |.. .| .|.||..|..|||.||...| |                   .|  ..||| |... | .  .
llllekansktllllefeellslkp.d.ysiallpenkdknrykdilpydhsrvklkped...................gvdldsdYinAsyvdgydllt

AEYIVTEAPIPATMNIFWRMVFEQGVSAIVVLTRELEAGRlRCHRYWPEEGQstIYADITVTTTAWREQPRSARRTLRLERPGCEpRRIEQLLFTAWPET
 ..|.| .| | |.. |||||.||||..|| ||.. | ||  |..||||||.   | |.|||.. . . .   .|||.... |.. | . ....| ||. 
rkfIatqgPlpetvedFwrmvweqgvtvivmLtklvelgr.kcaqywpeegg..tygdftvtllkvehldgytvrtlevtnnges.rtvthfqytgwpdh

GVPADPNAFLDFHREVQQCTRPNgNLTAPMVVHCSSGVGRSGCFVAFDRLAQSAARQlTPLSVKATILSLRHERMLMVQTVLQYEFVYKAVLRYLD
||| ... .|.| ..|... . . .   |..|||| ||||.|.|.| ... .   .    ..|. ..  ||  |. .|||  ||.|.|.|.| .| 
gvppslellleflelvrealael.pkggpvlVHCsaGvgRtGtfiaaylmleqleke.ggvdvleavkelreqRpgavqtpsqyrflydallellk
0043336 (Phosphotyrosine protein) phosphatases II 666-949 6.4e-67 221.3 In-house 19-277 (278) alignment 
Range on Protein: 666-949
Range on HMM: 19-277/278.0
NDGLQSEFATIEAADVrNTSVAAKRDANTHKHRYSNIFAYDHTRVRVTPDDAALRSDpapngdlttdegldvintdYIDANFIAGVSGKAEYIVTEAPIP
. .|. || ..   .. .|   |.. .| .|.||..|..|||.||......  | ||                   || |... | . . ..|.| .| |
ktllllefeellsfkl.dtysiallpenkdknrykdilpydhsrvklsllggdldsd...................YinAsyvdgynvprkfiatqgPlp

ATMNIFWRMVFEQGVSAIVVLTRELEAGRLRCHRYWPeeGQSTIYADITVTTTAWREQPRSARRTLRLER-PGCEPRRIEQLLFTAWPETGVPADPNAFL
 |.. |||||.|.||. ||.||.. | ||  |..|||  |.|. | |.|||..   ...   .|||....    |.| . .. ...||. ||| ... .|
etvedFwrmvwelgvttivmLtelvelgrvkcaqYwp..ggsltygdftvtllkeehlddytvrtlevtnlgdgesrtvthyhylgwpdhgvpeslslll

DFHREVQQCTRpngNLTAPMVVHCSSGVGRSGCFVAFDRLAQSAARQLtPLSVKATILSLRHERMLMVQTVLQYEFVYKAVLRYL
|| ..|... .   .   |..|||| ||||.|.|.| ..| . . . .  ...  ..  ||. |. .|||  ||.|.|.|.| ||
dflkavreale...dsngpvlVHCsaGvgRTGtfialyllleqlekeg.gvdleeavkelreqRpgavqtpsqyrflyealleyl
Y_phosphatase Protein-tyrosine phosphatase 693-946 1.2e-64 213.3 Pfam-A 1-234 (235) alignment 
Range on Protein: 693-946
Range on HMM: 1-234/235.0
NTHKHRYSNIFAYDHTRVRVtpddaalrsdpapngdlttdegL-DVINTDYIDANFIAGVSGKAEYIVTEAPIPATMNIFWRMVFEQGVSAIVVLTRELE
| .|.||..| .||.|||..                        .  ..||| ||.. | . | ..|.|..|.. |.. |||||... |..||.||.. |
nkkknRykdilpydktrvkl......................kgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltslee

AGRLRCHRYWP-EEGQSTIYADITVTTT-AWR-EQPRSARRTLRLERPGCE--PRRIEQLLFTAWPETGVPADPNAFLDFHREVQQCTrpnGNLTAPMVV
 ||  |..||| ||..|. | ||.|...     .. . . |.|.|.  . |  .|...|| .|.||. |||..|...||. |.|.. .    . ..|.||
kgrekcaqYwpeeeeesltygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkveksk...eaksgpvvV

HCSSGVGRSGCFVAFDRLAQSAARQLTpLSVKATILSLRHERMLMVQTVLQYEFVYKAVL
||| ||||.|.||| | | ... .. . ..|. .. .||..|. |||.. ||.|.|||.|
hCsaGvgRtgtfvaldilleqleaeee.vdvlqivkelRkqRpgmvqsleqYiflykail
Y_phosphatase Protein-tyrosine phosphatase 693-946 1.2e-64 213.3 In-house 1-234 (235) alignment 
Range on Protein: 693-946
Range on HMM: 1-234/235.0
NTHKHRYSNIFAYDHTRVRVtpddaalrsdpapngdlttdegL-DVINTDYIDANFIAGVSGKAEYIVTEAPIPATMNIFWRMVFEQGVSAIVVLTRELE
| .|.||..| .||.|||..                        .  ..||| ||.. | . | ..|.|..|.. |.. |||||... |..||.||.. |
nkkknRykdilpydktrvkl......................kgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltslee

AGRLRCHRYWP-EEGQSTIYADITVTTT-AWR-EQPRSARRTLRLERPGCE--PRRIEQLLFTAWPETGVPADPNAFLDFHREVQQCTrpnGNLTAPMVV
 ||  |..||| ||..|. | ||.|...     .. . . |.|.|.  . |  .|...|| .|.||. |||..|...||. |.|.. .    . ..|.||
kgrekcaqYwpeeeeesltygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkveksk...eaksgpvvV

HCSSGVGRSGCFVAFDRLAQSAARQLTpLSVKATILSLRHERMLMVQTVLQYEFVYKAVL
||| ||||.|.||| | | ... .. . ..|. .. .||..|. |||.. ||.|.|||.|
hCsaGvgRtgtfvaldilleqleaeee.vdvlqivkelRkqRpgmvqsleqYiflykail
0045098 (Phosphotyrosine protein) phosphatases II 685-949 8e-64 211.0 In-house 25-272 (278) alignment 
Range on Protein: 685-949
Range on HMM: 25-272/278.0
SVAAKRDANTHKHRYSNIFAYDHTRVRvtpddaalrsdpapngdlttdegldvintDYIDANFIAGVsgKAEYIVTEAPIPATMNIFWRMVFEQGVSAIV
   | .  | .|.||..|..|||.||.                             |||.|..| |   . ..|.| .| | |.. ||||..|.|...||
itpalylgnldknRykdilpydhsrVk.............................dYINAsyidgy..pkkfIatqgPlpstvadfwrmlwelgitviv

VLTRELEAGRLRCHRYWPEeGQSTIYADITVTTTAWREQPRSARRTLRLER-----PGCEPRRIEQLLFTAWPETGVPADP--NAFLDFHREVQQCTR--
 ||...| ||  |..|||| |.| .| |.|||.. . . .    |||...      ...|.| ...| .. ||. ||| .|  . ||.. ...... .  
mltelvelgrekcaqywpe.ggsltygdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkll

------------PNgnltAPMVVHCSSGVGRSGCFVAFDRLAQSAarQlTPLSVKATILSLRHERML-MVQTVLQYEFVYKAVLRYL
            ..     |..|||| ||||.|..|| . . .    .   ...  ..  ||  |.  .||.  ||.|.|...|..|
aslllsslllldsg....gpvlVHCsaGvgRtGtlvaaylmlell..e.ggvdlleavkelrsqRpglavqnleqyrflyefllell
0040439 (Phosphotyrosine protein) phosphatases II 687-949 7.7e-62 204.4 In-house 5-246 (249) alignment 
Range on Protein: 687-949
Range on HMM: 5-246/249.0
AAKRDANTHKHRYSNIFAYDHTRVRVTPddaalrsdpapngdlttdeGLDVINTDYIDANFIAGVSGKAEYIVTEAPIPATMNIFWRMVFEQGVSAIVVL
 |.. .| .|.||..|..|||.||....                     ..  .|||.|..| |   | ..|.| .| | |.. ||||..|.|...|| |
vallpenkdknrypdilpydhsrvklsi...................lpglflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmL

TRELEAGRLRCHRYWPEeGQSTIYADITVTTTAWREQPRSARRTLRLER-PGCEPRRIEQLLFTAWPETGVPADPNAFLDFHREVQQCTRPNgNLTAPMV
|.. | ||  |..|||. |.|. | |.|||..   . .   .|||.|..    |.|.. .. .| ||..||| ... .||| ..|... . . .   |..
tslvelgrekcaqywpl.ggsleygdftvtllsvevkddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleel.pkggpvl

VHCSSGVGRSGCFVAFDRLAQSAARQLTpLSVKATILSLRHERMLMVQTVLQYEFVYKAVLRYL
|||| ||||.|.|.| . . .   . |. .... ..  ||. |. .||.  ||.|.|.|.|..|
VHCsaGvgRtGtfiaaylmleqlekelg.vdleeavkllrsqRpgavqnpeqyrflyeallell
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 661-948 2.9e-61 202.1 In-house 15-278 (288) alignment 
Range on Protein: 661-948
Range on HMM: 15-278/288.0
QDLQRNDGLQSEFATIEAADVRNTSVAAKRDANTHKHRYSNIFAYDHTRVRVTpddaalrsdpapngDLTtdeglDVINTDYIDANFIAGVSGKAEYIVT
.. . ..|...|. .. | .  ... |...  | .| || || .||..||...              .|      .. ..|||.|..|.|  .| .|| |
ksarnrtgfseeynsLaalektksvtagrlavnakknRyrnilpyDekrvklk..............kle.....eeagaDYinasyidgekkkkkyiat

EAPIPATMNIFWRMVFEQGVSAIVVLTRELEAGRLRCHRYWPEEGQSTIYADITVTTTAWREQPRSARRTLRLERPGcEPRRIEQLLFTAWPETGVPADP
 .|...|.| ||..|.|. .| || ||  .| |. .|..|||.... . | ..||| .  .|.     |.| ||. . . ..| |. ..|||..|||.. 
qgPladtvndfWelvyenktstivmltelveggktkCeeYWPdadkpknyGsvtvtlveskeledfvlrklllekkk.teleitqyqylaWpdhgvPesk

NAFLDFHREVQQCTRPNgnlTAPMVVHCSSGVGRSGCFVAFDRLAQSAARqLTPLSVKATILSLRHERMLMVQTVLQYEFVYKAVLRY
. .|.. | |..    .   | |..|||| ||||.| |.| | | .   .    . | .|.  ||..|.|.|||. ||||.|...|  
apllellrqvkvanqad...tgpiivhCsaGvGrtgtFialdalidavee.edyiDvagtvaklRkqRallvqtlkqYefiyevllsl
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 664-950 6.4e-61 201.2 In-house 24-291 (298) alignment 
Range on Protein: 664-950
Range on HMM: 24-291/298.0
QRNDGLQSEFATIEAADV---RNTSVAAKRDANTHKHRYSNIFAYDHTRVRVTPDDAalrsdpapngdlttDEgldviNTDYIDANFIAGVSGKAEYIVT
..  |...|| ....      .... .|....| .| ||..| |.|..||... .||              ||     ..||| | |. . .|.  .|.|
kkltgyalefqrlnsvsseieeeekevarkpenkkkNRyadiialdssRvvLekeda..............de.....esdYiNAsflhaykgrnafiat

EAPIPATMNIFWRMVFEQGVSAIVVLTRELEAGRLRCHRYWPEEGQsTIYADITVTTTAWREQPRSARRTLRLERPG-CEPRRIEQLLFTAWPETGVPAD
.||...|.. ||||| |. ...||.||   | .....|.|||.||. . | .|||.  .  |.   . |.| ...    . |.. || || ||. |||. 
qaPltetvedFWrmvteedigtiVmltnleeldktkyhkywPdegk.etygeitvsllskeefadlivrklkvskkkeekerevrqlhftsWpdkgvpen

PNAFLDFHREVQQCTRPNGNltAPMVVHCSSGVGRSGCFVAFDRLAQSAARQlTPLSVKATILSLRHERMLMVQTVLQYEFVYKAVLRYLD
 .. ||. |.|.. .. .||  .|..|.||.|||||| |.| | . . . ..   . |  ..  ||..|. .|||  || |.|.|||..||
atsvldllrkvrasqqqagn..kpvivqCsaGvgRsGtfiaidsvlervkke.qvvDvfqvvkvlRkkrpgavqteeqYvfiyeavleald
0042113 (Phosphotyrosine protein) phosphatases II 689-949 1.1e-60 200.4 In-house 5-243 (245) alignment 
Range on Protein: 689-949
Range on HMM: 5-243/245.0
KRDANTHKHRYSNIFAYDHTRVRVTPDDAALRSDpapngdlttdegldvintdYIDANFIAGVSGKAEYIVTEAPIPATMNIFWRMVFEQGVSAIVVLTR
.. .| .|.|||.|..||||||...||.  | ||                   || |... |   .  .|.| .| | | . ||||..|.|...|| ||.
llpenkdknrysdilpydhtrvklspdggdldsd...................yinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLte

ELEAGRLRCHRYWPEeGQSTIYADITVTTTAWREQPRSARRTLRLER-PGCEPRRIEQLLFTAWPETGVPADPNAFLDFHREVQQCTRPngNLTAPMVVH
| | ||  |..|||. |.|. | |.|||..     .   .|||.... .  |.| . ..... ||. ||| ... .|||...|... .   .   |..||
eeelgrvkcaqywpl.gesltygdftvtllseehlddytvrtlevtnlgddesrevihyhylpwpdhgvpdllellldflefvrkalae..dsngpvlVH

CSSGVGRSGCFVAFDRLAQSAARQlTPLSVKATILSLRHERMLMVQTVLQYEFVYKAVLRYL
|| ||||.|.|.| ..... . .    .|.  ..  ||  |. .|||  ||.|.|.|.| .|
CsaGvgRtGtfiaaylmleqleke.lgvsleeavkelrsqRpgavqtpsqyrflyeallell
subfamily_PTPN6_pd Subfamily PTPN6 653-952 3.3e-60 198.7 In-house 13-300 (306) alignment 
Range on Protein: 653-952
Range on HMM: 13-300/306.0
QNALRQhFQDLQRNDGLQSEFATIEAADVRN--TSVAAKRDANTHKHRYSNIFAYDHTRVRVTpddaalrsdpapN-GdlttDEGLDVINTDYIDANFIA
 . |..  ..   . |.. || ...  ....  .   ...  |..| || ||. .||||| ..            . .      | | ||..||. ..  
vselek.eeeslekagfeeefeelqqeeakkllsrkegakpenkeknryknilPfDhtrvilk............eps....vpgsdyinanyikkevkg

GVsgkAEYIVTEAPIPATMNIFWRMVFEQGVSAIVVLTRELEAGRLRCHRYWPEEGQSTIYADITVTTTAWREQPRSARRTLRLE--RPGCEPRRIEQLL
     ..|| |.  ...|.. |||||...    ||..|.|.| |. .| ||||.| ... | .|.||... ... .   |.|...  . . | |.. |. 
sd...ksyiatqgclettvsdFWrmvwqensrvivmttkevErgkekCarYWPdeeekeeyGkisvtnvseksladYilRelsvskkkkkkeerevfqyh

FTAWPETGVPADPNAFLDFHREVQQCTRPNG-NLTAPMVVHCSSGVGRSGCFVAFDRLAQSAARQ--LTPLSVKATILSLRHERMLMVQTVLQYEFVYKA
|..||. |||.||.|.||| ..|.. ..    . . |.|||||.|.|| | |.  | | .   ..   ... .. .. |.|. |  .|||  || |||||
fksWPdhgvpkdpgavLdfledvnrkqeeleeaeagpivvhCsaGiGRtGtfiviDillkliekkgldadidiqklvksvreqrsglvqteqqykfvyka

VLRYLDLE
.  |.. .
ikkyietk
subfamily_PTPN12_pd Subfamily PTPN12 680-955 6.5e-59 194.2 In-house 27-283 (290) alignment 
Range on Protein: 680-955
Range on HMM: 27-283/290.0
DVRNTSVAAKRDANTHKHRYSNIFAYDHTRVRVTPDDAALrsdpapngdlttdegldviNTDYIDANFIAGVSGKAEYIVTEAPIPATMNIFWRMVFEQG
.   .. |.... |..| || .|. ||..|| .. ..                      . |||.|||| ||.|| ||| . .|.|.|.. ||||..|. 
ekvysteagekeenvkknrykDilPydksrvelskieeee...................gsdYinanfikgvegkleyiaaqgPLpktlddfWrmiwekn

VSAIVVLTRELEAGRLRCHRYWPEEGQSTI-YADITVTTTAWREQP-RSARRTLRLERPgCEPRRIEQLLFTAWPETGVPADPNAFLDFHREVQQCTRpn
|. .|.. ||.| |. .|.|||||||.... .....||... .        |||..|.   | |...|. .||||. |||. ..  |.. ..|..  .  
veivvmaCrevelgkkkCerYWpeegeeelefgefevtleeekavdddflirtLkveaq.kesrkvyqfhYtaWPDhgvPssaksllelielvrelqe..

gNLTAPMVVHCSSGVGRSGCFVAFDRLAQSAARQLT--PLSVKATILSLRHERMLMVQTVLQYEFVYKAVLRYLDLELQK
 .  ||.|||||.|||| |  .| |   .   .. .   |.|   .|.||..|  .|||  |||.|||||. ..  ||. 
.sedaPlvvhCsaGvGrtGtiiaidyvrellkaekipeeldvfdlvlelrkqraalvqtkeqyelvykavaelvqkelei
subfamily_PTPRA_pd Subfamily PTPRA 665-950 3.5e-58 192.1 In-house 30-299 (330) alignment 
Range on Protein: 665-950
Range on HMM: 30-299/330.0
RNDGLQSEFATIEAADVRNTSVAAKRDANTHKHRYSNIFAYDHTRVRVTPDDaalrsdpapngdlttdeGLDviNTDYIDANFIAGVSGKAEYIVTEAPI
 |  .. || .. |.....|  .|... | .| |. ||. ||..|| ... .                 | .  ..|||.| || |   | ..| .  | 
dnklfreefnalPagpiqatlelaskeenkeknrvvnilPydfsrvilsvke.................Gve..esdyinasfidGykekdkfiaaqGPk

PATMNIFWRMVFEQGVSAIVVLTRELEAGRLRCHRYWPEEGQSTiYADITVTTTAWREQPRSARRTLRLE-RP-GC---EPRRIEQLLFTAWPETGVPAD
  |.. ||||..||  ..||.||   |  . .|..|||.||  | | .|.|.     .    . | . ..  | ..   ..| ..|. ||.||. |||..
eetvedfwrmiweqksativmltelkerkeekcaqywPdeGlvt.yGnirvevedetvlvdytvrkflvqqlpdatrekksrlvrqfhftswPdvGvPfe

PNAFLDFHREVQQCTRPNGNltaPMVVHCSSGVGRSGCFVAFDRLAQSAaRQLTPLSVKATILSLRHERMLMVQTVLQYEFVYKAVLRY---LD
|   |.. ..|... . ...   |.|||||.||||.| |...| . .   .    . |  .. .||  |  ||||  ||||.||..| |    |
piGmlkllkkvkklnqqsag...pivvhcsaGvGrtGtfivldavlerv.kaerkvdvfefvkrlrlqrpqmvqtdeqyefiykvlleyylygd
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 651-951 9.8e-58 190.7 In-house 5-285 (319) alignment 
Range on Protein: 651-951
Range on HMM: 5-285/319.0
LQQNALRQHFQDLQR--NDGLQSEFATIEAADVRnTSVAAKRDANTHKHRYSNIFAYDHTRVRVTPDDaalrsdpapngdlttdeglDVINTDYIDANFI
.. . |..... |.   . .|. || ... |.   |   |... | .| ||.|| |||.||| ... |                   .| ..|||.|.||
ievqeLkerlkalastgetllekefkllkeavnd.tfdsaskeenkkknryqnilaydrtrvvlseld...................gvegsdyinasfi

AGVSGKAEYIVTEAPIPATMNIFWRMVFEQGVSAIVVLTRELEAGRLRCHRYWPEEgQSTIYADITVTTTAWREQPRSARRTLRLERPGCEP--RRIEQL
 |   . ..| | ||.  |.. |||||.|...| .|.||.  | .......||||| . . |  ..||    .|.     | | |..   |   |.. . 
dgyqerekfiatqaPlentiedfWrmvWeeessivvmltklveklkvklkkywpee.nfeeyGrlivtleeeeeledyiirklklnkkssevetRevkhf

LFTAWPETGVPADPNAFLDFHREVQQCTRpnGNLTAPMVVHCSSGVGRSGCFVAFDRLAQSAARQlTPLSVKATILSLRHERMLMVQTVLQYEFVYKAVL
 .|.||. .|| .  . ||. ..... ..  ..   |.||||| |||| | |.. |   .   .. . | |  |.  ||  | .|||.  ||.|.|.|.|
qyteWpdhdvPekatslldllkrirksre..ktqsgPivvhCsaGvGRtGtfivldamlervkee.gvlDvfstvsrlRtqRnimvqrpeqYkfiyeall

RYLDL
 ... 
eavea
0037934 (Phosphotyrosine protein) phosphatases II 688-948 3.3e-57 189.1 In-house 5-241 (243) alignment 
Range on Protein: 688-948
Range on HMM: 5-241/243.0
AKRDANTHKHRYSNIFAYDHTRVRVtpddaalrsdpapngdlttdEGldvinTDYIDANFIAGVsGKaeYIVTEAPIPATMNI----FWRMVFEQGVSAI
|.. .| .|.|||.|..|||.||..                    ||     .|||.||.| .. ..  .|.| .| | | .     ||||..|.|...|
allpenlsknrysdilpydhsrvkl....................eg.....sdyinanliyvt.pr..liatqgPlpetveddlasfwrmlwelgitvi

VVLTRELEAGRLRCHRYWPeegQSTIYADITVTTTAWREQPRSARRTLRLER--PGCEPRRIEQLLFTAWPETGVPADPNAFLDFHREVQQCTRP-----
| ||.. | ||. |..|||   ... | |.|||..  .. .    |||.||.  .. ..| . ......||. ||| .|. .|||..||... .      
vmltelvElgrekcaqywp...gevtygdftvtllseehlddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsll

NGNLTAPMVVHCSSGVGRSGCFVAFDRLAQSAarqltPLSVKATILSLRHERML-MVQTVLQYEFVYKAVLRY
. .   |..|||| ||||.|...| . . .        ...  ..  ||  |.  .|||  ||.|.|.|.| .
aldsggpvlVHCsaGvgRtGtliaaylmllll.....gvdleeavkllreqRpgkavqtpsqyrflyeallel
subfamily_Ptp69D_pd Subfamily Ptp69D 659-950 3.9e-57 188.7 In-house 12-287 (307) alignment 
Range on Protein: 659-950
Range on HMM: 12-287/307.0
HFQDLQRN--DGLQSEFATIEAADVRNTSVAAKRDANTHKHRYSNIFAYDHTRVRVTPddaalrsdpaPNGDLttdegldviNTDYIDANFIAGVSGKAE
 ..  .|.   ||. |. ..||  .  ........ |. | || .| |.|.|||....           ||.          ..|||.|.|| |   | .
alksrkrdtdfglakeyekLeareidkstkvsekkenalknRyedikafDktRvkLkk..........ingke.........dsdYinasfikgykekkk

YIVTEAPIPATMNIFWRMVFEQGVSAIVVLTRELEAGRLRCHRYWPEEgQSTIYADITVTTTAWREQPRSARRTLRLERPG-C-----EPRRIEQLLFTA
.|.  .|. ||.. ||||. || |  ||.|. . |  | .|..|||.| . . | || |..   ....  ..|.| . . . .     . |.. |  .|.
fiaaqdPveatigDfWRmiaeqevtlivmlsnlteknrkkcakYWpie.devqygdilvklvseekhsdyiiReldvskkkeesgevedsrkvvqyhytg

WPETGVPADPNAFLDFHREVQQCTRPNgnlTAPMVVHCSSGVGRSGCFVAFDRLAQSAaRQLTPLSVKATILSLRHERMLMVQTVLQYEFVYKAVLRYLD
|... ||  ... |.. ..|..  . |    .|.||||| |||||| |||.| | |   ..   ... .|.  ||..| |.||   ||.|.|.|.| | .
WkDskvPevargllklieqvrelykln...rsPivvhCsaGvgrsgifvaldsllqql.kaedkvdifetvkdLrsqRnllvqsleqYvflyralldyss
subfamily_PTPN9_pd Subfamily PTPN9 656-949 1.4e-55 183.4 In-house 6-290 (297) alignment 
Range on Protein: 656-949
Range on HMM: 6-290/297.0
LRQHFQDLQrNDGLQSEFATIEAADVRNTSVAAKRDANTHKHRYSNIFAYDHTRVRVTPDDaalrsdpapngdltTDEgldviNTDYIDANFIAGVSGKA
| .. .. . . ||. |.| | .  |  |  |.|  || .| ||...  ||.||| ..  |               ||     ..|||.|||. |   | 
lvayvkekg.krGlskeyaeirnepveGtflasklranleknrytdvlcydetrvvlakvd..............ede.....asdyinanfvdGykqkk

EYIVTEAPIPATMNIFWRMVFEQGVSAIVVLTRELEAGRLRCHRYWP-EEGQSTIYADITVTTTAWREQPRSARRTLRLE-RPGCEPRRIEQLLFTAWPE
 .| |  |.. |.. |||||.|| |  ||. || .| |||.| .||| ||..|. ..|..|..   .|.     |.| ..     | |..    |..||.
afiatqGplkktvsdfWrmvWeqevlvivmttrvvergrlkcgqyWpleeessaefgdlsvsnveveeeedykvrvleiknvkteesrkvthfqflsWPd

TGVPADPNAFLDFHREVQQC---------TRPNGNLT-APMVVHCSSGVGRSGCFVAFDrLAQSAARQLTPLSVKATILSLRHERMLMVQTVLQYEFVYK
 ||| . ...||. ..|..           . .|...  |.|||||.|.||.| |...| .. |  .... . |  |.  ||  |  ..||  |||| |.
yGvPssaaslldvlekvrekqalavkelgdewkghpsgPPivvhcsaGiGrtGtfitld.iclsrleevgtvdvvetvkllrtqrafsiqtpeqyefcyl

AVLRYL
||| | 
avleya
subfamily_PTPN23_pd Subfamily PTPN23 667-956 6.3e-55 181.0 In-house 15-287 (288) alignment 
Range on Protein: 667-956
Range on HMM: 15-287/288.0
DGLQSE---FATIEAADVRNTSVAAKRdANTHKHRYSNIFAYDHTRVRVTpddaalrsdpapngdlttdegldVINTDYIDANFIAGVSGK-AEYIVTEA
 .|. .   . . .... |..|.|. .  ...| |. .|. |||.|| .                          . |||.| |. ..|    ..|.| |
taldkkfkeleqkqdkearkrsiaiak.lyseknrsrdilPyDhnRvklr.......................gskDDYinAsfvkdlspgcPdfiatqa

PIPATMNIFWRMVFEQGVSAIVVLTRELEAGRLRCHRYWPE-EGQSTIYADITVTTTAWREQPRSARRTLRLERPGC-EPRRIEQLLFTAWPETGVPADP
|.. |.| ||.||.|| .| ||.|. . | |. ...||||| .|... . |..||    || .   .|.|.||  .  . . .  | .|.||| |||| |
PlqstlnDFWlmvyeqkssviVmllskeelgkpkvdrYwPedkgetvkfgdlsvtlksvretethvervlkletldadavksvshlqltsWpelGvPasP

NAFLDFHREVQQ-CTRPNGNLTAPMVVHCSSGVGRSGCFVAFDRLAQSAARQLTPLSVKATILSLRHERMLMVQTVLQYEFVYKAVLRYLDLELQKH
. .|.|  ||..  .  . .. .|.|||||.||||.| |      ..   ..   | .   .  ||..|  |||.. |..|.|.|||..    |.|.
etllqfldevesayeavqrksktPlvvhCsaGvgRtgvfalvyaavrelekgnglldiiqvvsrlreqRrfmvqekeqlkfsyeavleaarrvldkr
subfamily_PTPN3_pd Subfamily PTPN3 684-948 1.2e-54 180.2 In-house 32-274 (280) alignment 
Range on Protein: 684-948
Range on HMM: 32-274/280.0
TSVAAKRDANTHKHRYSNIFAYDHTRVRvtpddaalrsdpapngdLTTDEGlDVINTDYIDANfIAGVSGKAEYIVTEAPIPATMNIFWRMVFEQGVSAI
.  ||.. .| .| || .| .||.|||.                 |.  |  | ||..|.. . | . .    ||.|  |.. |.. ||.||.|| .| |
aisaarkpenlsknryrdilpydatrvk.................lkeset.dyinanyvnme.ipstglvnryiatqGPlaktatdfWqmvweqkssli

VVLTRELEAGRLRCHRYWPEEGQSTIYADITVTTTAWREQPRSARRTLRLERPG-CEPRRIEQLLFTAWPETGVPADPNAFLDFHREVQQCTrpnGNLTA
|.||  .| || .||.||||..... |....|. .  .|.   . | | |..    | |.| || ..|||. ||| |.. ||.| ..|...       . 
vmlttlverGrvkChqyWPetedeleygefsvkcekedetksyvlrelvlkdketkeerkilqlqylaWpdhgvPddsadflefvervrklr...sgkee

PMVVHCSSGVGRSGCFVAFDRlAQSAARQLTPLSVKATILSLRHERMLMVQTVLQYEFVYKAVLRY
|.|||||.|.||.| .....  | .   .  |. . . .  .|  |. .|||. ||.|| .|.|. 
PvvvhCsaGigrtGvlillet.alalieaaepvypldivrtmrdqramlvqtasqykfvCeailkv
subfamily_PTPN14_pd Subfamily PTPN14 655-950 2.8e-54 179.2 In-house 11-297 (300) alignment 
Range on Protein: 655-950
Range on HMM: 11-297/300.0
ALRQHFQDLQRNDGLQSEFATIEAADVRNTSVAAKRDANTHKHRYSNIFAYDHTRVRVTPddaalrsdpapngdlTTDEgldviNTDYIDANFIA-GVSG
.......   ..  .  |.  |       .  .|| . |..| |. ..  |...||...|               | ..     .|.||.|  |   |.|
krakilekkleegkvfteyeripkkredallstaklpenaeknrfkdvlPyednrvelsp...............tken.....stgyinassikvsvgg

-KAEYIVTEAPIPATMNIFWRMVFEQGVSAIVVLTRELEAGRLRCHRYWPEE---GQSTIYADITVTTTAWREQPRSARRTLRLER-PGCEPRRIEQLLF
 . .|||. .|.. |...||.||.||||. || ||.| | |. ....|.|..    ..  .    |||   .. .. . ..|.|.  |  | | .  | .
kersyivaqgPleltvqdfWqmvWeqgvqlivmlteeeedgkeksfkyfPkleskkktvefgkfkvttkfsedsdsvittglklkhlpskeertvwhlqy

TAWPETGVPADPNAFLDFHREVQQCTRPNG------NLTAPMVVHCSSGVGRSGCFVAFDRLAQSAARQlTPLSVKATILSLRHERMLMVQTVLQYEFVY
| ||. ||| |.. ||.. .|||   |         .   |..|||| ||||.|  .  | | ..   .   . .| ..  ||. |||.|||. ||.|||
tDWpdhgvPeDvkgflsyLeevqsvrrktnseveskeskPPvlvhCsaGvGrtGvlilsdlliatlehn.eeidikkvlarLreqrmllvqtlaqYkfvY

KAVLRYLD
|....||.
kvlikylk
subfamily_PTPRK_pd Subfamily PTPRK 654-947 6.3e-53 174.6 In-house 7-275 (314) alignment 
Range on Protein: 654-947
Range on HMM: 7-275/314.0
NALRQHFQDLQR--NDGLQSEFATIEAAdvrntSVAAKRDANTHKHRYSNIFAYDHTRVRVTPDDaalrSDPapngdlttdegldviNTDYIDANFIAGV
. | |. . |.|  . |.. |. ..          |||.| | .| |. .| |||..||.... |     ||               ..|||.|..| . 
adllqsiallkraegygfkeeyeslfeg.....wdaakkdenreknrsgdilaydrsrvflitid....gdp...............ssdyinaalidsy

SGKAEYIVTEAPIPATMNIFWRMVFEQGVSAIVVLTRELEAGRLRCHRYWPEEGQStiYADITVTTTAWREQPRSARRTLRLER---PGCEPRRIEQLLF
   |..|||  |.. |.. |||.|.... ..||.||   | ||..| .||||...   | || |.      .     |..|.|.   .  | | . |. |
krpaafivtqgPlqetvkdfWrlvydencasivmltelvevgrvkClkyWPedtev..ygdikvelvetellaelvvrifrveklargqeeirevrqfqf

TAWPETGVPADPNAFLDFHREVQQCTRPngnLTAPMVVHCSSGVGRSGCFVAFDRLAQSAARQLTpLSVKATILSLRHERMLMVQTVLQYEFVYKAVLR
..||. .||   ...|.. |.|.. . .      ..|||||.| ||.|.|.| | . . . |. . . |  .. .|| ... ||.|  || |.| ..| 
lgWpdhdvPvsatgllklvrrvkksqee...eaGrivvhCsaGaGrtGtfiaidivldmieregv.vdvfnavktlrsrkvnmveteeqykfiydvile
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 688-951 6.8e-53 174.4 In-house 4-244 (250) alignment 
Range on Protein: 688-951
Range on HMM: 4-244/250.0
AKRDANTHKHRYSNIFAYDHTRVRVTPDDAalrsdpapngdlttDEgldviNTDYIDANFIAGVSGKAEYIVTEAPIPATMNIFWRMVFEQGVSAIVVLT
||. .| .| ||..| |.|..|| . ....              |.     ..|||.| |. | ...  .|.| .|..||.. |||||.|. ...||.||
akkpqnkeknryadiialdssrvvLekekg..............dk.....esdyinasflhgyderkafiatqgPlqatiedfWrmvleeksgtivmLt

RELEAGRLrCHRYWPEEgQSTIYADITVTTTAWREQPRSARRTLRLERPGCE-PRRIEQLLFTAWPETGVPADPNAFLDFHREVQQCTRPNGNltAPMVV
   | ..  .|.||| | ....| |.||.     |      |.| | .   .  | . || |..||. |||.  .| |.. ..||.  .  ||  ||..|
nLkesekt.yhqywPve.kaekyGdvtvsllskeefadytkrklklskakkaderivrqlhfvvWPdkgvPevatavLellkkvqasqqqagn..aPviv

HCSSGVGRSGCFVAFDRLAQSAARQlTPLSVKATILSLRHERMLMVQTVLQYEFVYKAVLRYLDL
.||.||||||.|.| | . . . ..   . |   |  ||..|. .|..  || |||...|..|| 
qCsaGvgrsGafiaidavlerlkke.kvvdvfkvikvlrkdrphavesleqyvfvyeiilkalds
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 669-950 2.5e-51 169.4 In-house 7-269 (274) alignment 
Range on Protein: 669-950
Range on HMM: 7-269/274.0
LQSEFATIEAAD-VRNTSVaakrDANTHKHRYSNIFAYDHTRVRVTPDDAAlrsdpapngdlttdegldVINTDYIDANFIAGVSGKAE-YIVTEAPIPA
|..||  . .    ....|      ...| || .|.  ...|| ......                     ...||.||.| | ... . |. |  |.| 
lekeflelPlnfdqeeldv....fgsqtknryktilPnensrvllesesse..................dedssyinanyikGydeeskayvatqGPlpn

TMNIFWRMVFEQGVSAIVVLTRELEAGRLRCHRYWPEEGQS---TIYADITVTTTAWREQPRSARRTLRLERPGCePRRIEQLLFTAWPETGVPADPNAF
|.. ||||.... |. ||.||.  || . .|..|.|.. .      | |. ....   |.     |.| |.     .|..   ..|.||.. .| |.|..
tvadfWrmiyqeevqvivmltklkeaneqkCavyfPdaedyeiserygdveikvekiverndysvrklvlkyler.ersvkhywytdWPdhksPddantl

LDFHREVQQCTRPNGNLTAPMVVHCSSGVGRSGCFVAFDRLAQsAARQLTPLSVKATILSLRHERMLMVQTVLQYEFVYKAVLRYLD
||. .||..  . . . .||.|||||.|.|| |||.| .   .   |. . . |  ..  || .|  ||||  |||....|.  || 
ldlvleveesreeenaklapvvvhCsaGiGrtGcfiaisiavr.qlreeivvdvlkivcnlrldrGGmvqtseqyelihralclylk
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 665-947 6.2e-50 164.9 In-house 22-277 (315) alignment 
Range on Protein: 665-947
Range on HMM: 22-277/315.0
RNDGLQSEFATIEAADVRNTSVAaKRDANTHKHRYSNIFAYDHTRVRVTpddaALRSDPapngdlttdegldviNTDYIDANFIAGVSGKAEYIVTEAPI
 ..|.. .. .|   ...   || |.  | .| || || |||..||..      |  ||               ..||..|||| | . |  || ...| 
tkngfkqdyesipggqlhpldva.kkienkqknryiniiaydksrvqlp....llendp...............hsdyvnanfidGynkkrryiaaqgpn

PATMNIFWRMVFEQGVSAIVVLTRELEAGRLRCHRYWPEEgqSTIYADITVTTTAWREQPRSARRTLRLeRPGCEPRRIEQLLFTAWPETGVPADPNAFL
.|... |||.|||. .. ||.||   |  . .. .|||..    ||  ||||      . . . |||     | . | . || .|.||..|||.   ...
vasvkdfwrlvfeedigkivmltnlvegekrkaekywpdk..kviyGkitvtrkseevnteytvrtlsv.vfgdnirevvqlhytswpdmgvpkytiplm

DFHREVQQCTRPNGnltAPMVVHCSSGVGRSGCFVAFDRLAQSAARQlTPLSVKATILSLRHERMLMVQTVLQYEFVYKAVLR
...| |.|    .    ...|||||.||||.| |...| . . |  .   . |   |  .|. |. |||.. ||.|.|.|.| 
nlirtvkqhhtnsv...gaivvhcsaGvGrtGtfitldavldqaeae.naidvynfitgvrqnrikmvqvaeqyqfiydalle
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 693-952 9.4e-50 164.1 In-house 20-267 (270) alignment 
Range on Protein: 693-952
Range on HMM: 20-267/270.0
NTHKHRYSNIFAYDHTRVRVtpddaalrsdpapngdltTDEGLDvINTDYIDANFIAGVSGK-AEYIVTEAPIPATMNIFWRMVFEQGVSAIVVLTRELE
...  || .|    .||||.                   ..  |  .| || ||...|..|. ..|| . .| |.|.. ||||..|. |.|||..|   |
gkklnRyadiLPsPatRvrl..................eeleed.sataYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleE

AGRLRCHRYWPEEGQS---TIYADITVTTTAWREQPRSARRTLRLERPGcEPRRIEQLLFTAWPETGVPADPN------AFLDFHREVQQCTRPNGNLTa
 || .| ||||.| ..   . . .|.|.... . .  . .. ||||. | | ||.    ...||. ||| ...        |   |.|.. ..   . . 
kgrkkCerYWpaepkekvkledgkikvlalseekeegyiltrlrleekg.eerrlvHfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkae.

PMVVHCSSGVGRSGCFVAFDRLAQSAARQlTPLSVKATILSLRHERMLMVQTVLQYEFVYKAVLRYLDLE
|..|||| ||||.|...| |   .   .. . . | | |  ||..|| .||.. ||||.||||. | .  
PllvHcsaGvgRtGtlialDiavrlLeet.kkvdvlaiieelRkdRmalvqhpeqyeflykavveyaerr
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 664-952 6.2e-49 161.7 In-house 23-287 (297) alignment 
Range on Protein: 664-952
Range on HMM: 23-287/297.0
QRNDGLQSEFATIEAADVRNTSVAAKRdANTHKHRYSNIFAYDHTRVRVtpddAALRSDPapngdlttdegldviNTDYIDANFIAGVSGkaEYIVTEAP
.. |  . ||  . .| .... || |.  | .| ||.||  ||  ||..    | . .||               . ||..| |. |.    ..| |. |
rhtdvfseeflclpeaniqpqtvaekk.vnfeksRYkniLPydssRvkL....aivnddp...............dsDyvnasfvkgnkh..rlittqmP

IPATMNIFWRMVFEQGVSAIVVLTRELEAGRlRCHRYWPEEGQSTiYADITVTTTAWREQPRSARRTLRLERPGCEPR-RIEQLLFTAWPETGVPA--DP
 .||.. ||.||... ||.||.|. . |  . .| |||...| .| . |..|....  |.    .|.| ...     |  ..|  |. ||.  |.   . 
mkatvadfWamvldeqvstivmlnddnerdk.kcaryWsdkgvtt.fGdvsvvllsvsereGfikrelevtkgkakarrvvkqyqfveWPdkaverkdsa

NAFLDFHREVQQCTRpnGNLTAPMVVHCSSGVGRSGCFVAFDRLAQSAARQlTPLSVKATILSLRHERMLMVQTVLQYEFVYKAVLRYLDLE
...|..  ||..     .|  .|..|||..|||| | ... |     | |.   . .  ..  ||.||. .|||  ||.|||.||| .|  |
ssllklisevrkdfs..qnaegPllvhclaGvGrtgvlltidsvvaeakre.kevdifglvkklrqerpylvqtkeqykfvyvavleallse
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 670-950 7.3e-49 161.3 In-house 22-278 (315) alignment 
Range on Protein: 670-950
Range on HMM: 22-278/315.0
QSEFATIEAADVRNTSVAaKRDANTHKHRYSNIFAYDHTRVRVTPDDaalrSDPapngdlttdegldviNTDYIDANFIAGVSGKAEYIVTEAPIPATMN
  ||  .   |. .. || . . | .| || ||. .|..||..   |     .|               . |||.| .| .|     || . .| .|...
seefhdlpdPdiyrqrva.retinfkknryknilPldsarvklevid....dsP...............dsdyinasyiksvdddkayiasqgPlkasvd

IFWRMVFEQGVSAIVVLTRELEAGRLRCHRYWPE-EGQSTIYADITVTTTAWREQPRSARRTLrLERPGCEPRRIEQLLFTAWPETGVPADPNAFLDFHR
 |||||... |..||..|   |  ...| .|||. ...|. .  | |..     .     | |   | . | |.. |  || ||. ||. .  ..| . .
dfwrmvlqekvttivmvtkkqegdkikcrqywPdrkadsvefGsikvellsleadtdgvarkl.vtrkseesrtvtqfqftewPdkGvdkqtssllklik

EVQQCtrpNGNLTAPMVVHCSSGVGRSGCFVAFDRLAQSAARQlTPLSVKATILSLRHERMLMVQTVLQYEFVYKAVLRYLD
||.     ||. . ...||||.||||.| ... |   . ..|.   . |  ..  || .|. .|||  .| |.| ||| .| 
evkad...ngkkefsllvhcsaGvGrtGvvisidevvaqikrt.rsvdvfnfvknlrakrpylvqteeeyafiydavledll
subfamily_PTPRG_pd Subfamily PTPRG 655-949 2.2e-48 159.8 In-house 5-287 (563) alignment 
Range on Protein: 655-949
Range on HMM: 5-287/563.0
ALRQHFQDLQRND--GLQSEFATIEAADVRN--TSVAAKRDANTHKHRYSNIFAYDHTRVRVTPddaalrsdpAPNGDLttdegldviNTDYIDANFIAG
 . .|  .|  ..  |.. ||  ..   . .  .  ....  | .| ||.|| |||..||...|          |. .          . ||| ||.| |
efakhvaslhadgdigfseefealqsetiskdldaehsqkpenkrKnRylnivaydrsRvklsp.........lpgkkk.........klDYinAnyidG

VSGKAEYIVTEAPIPATMNIFWRMVFEQGVSAIVVLTRELEAGRLRCHRYWPEeGQSTIYADITVTTTAWREQPRSARRTLRLER------PGC-EPRRI
   . ..|.|  |.. |.. ||||..|| |. ||..|   | ||  |..|||.  .|  |  ..|| ..      .. ||| ..         | . ...
yqkskafiatqgplkdtfddFWrmiWeqnvaiivmitnlvergrrkcdvYWPk.desetygalqvtlieeevlalytvrtlviknlklkkkkqcdteklv

EQLLFTAWPETGVPADPNAFLDFhreVQQCTRPNGNLTAPMVVHCSSGVGRSGCFVAFDRLAQSAARQlTPLSVKATILSLRHERMLMVQTVLQYEFVYK
 |  .| ||..|||  .   | |   |..  . | . . |.|||||.||||.| ....| | .   ..     |  ..  .| .|  .|||  || |...
rqyhytkWPdhgvPehslpvLif...vkkssaankaeaGPivvHcsaGvgrtGtyivldtllkqiqqe.navnvfgflkhiraqRnflvqteEqYiflhd

AVLRYL
|.|  .
alleai
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 664-949 2.8e-48 159.6 In-house 19-283 (305) alignment 
Range on Protein: 664-949
Range on HMM: 19-283/305.0
QRNDGLQSEFATIEAAdvRNTSVAAKRDANTHKHRYSNIFAYDHTRVRVTPDDaalrsdpapngdltT-DegldviNTDYIDANFIAGVSGKAEYIVTEA
. ..||. .. ..      ..    |..||..| |...|. .|. |...|...              . |      ..|||.|... | ..| .|||. .
ysdkgleaqykslyee..eesidvgkkeankaknrlkeitlldddriilteke..............sld......dsdyinasyvdgykrkkkyivaqg

PIPATMNIFWRMVFEQGVSAIVVLTRELEAGRLRCHRYWPEEGQS-TIYADITVTTTAWREQPRSARRTLRLER--PGCEPRRIEQLLFTAWPETGVPAD
|.. |.. |||...|  || || ||.  | |. .|..||||. .  . . ...|. .  .. .    | |..       | | . |. .| ||. |||  
PlkntvadfWrliveekvstivmltklveggkdkCrqYWpesktekkefgefsvelksektasdyieRklkisiededkesrtvlqyqltdWPdhGvpqf

PNAFLDFHREVQQCTRPNGNltAPMVVHCSSGVGRSGCFVAFDrLAQSAARQLTPLSVKATILSLRHERMLMVQTVLQYEFVYKAVLRYL
. ..|.. ..||.  . . .   |..|||| ||||.| |.| | .|   ...   . |   .  ||..|| ||||  || |.. |.  ..
atsllslikrvqkdqkkdkg..vpllVhCsagvgRtGvfiavd.ialerlkkEevvdvfevlkqlRskrmkmvqtldqYvflhdaldeli
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 665-951 2.3e-46 153.1 In-house 18-280 (287) alignment 
Range on Protein: 665-951
Range on HMM: 18-280/287.0
RNDGLQSEFATIEAADVRNTSVAAK-RDANTHKHRYSNIFAYDHTRVRVTpddaalrsdpapngdlttdegldVINTDYIDANFIAGVSGKAEYIVTEAP
 |.| .  |...|  . |. .|  .    | .| |...|  .|  || .                          . |||.| || | . | ..|..|.|
gnegfknqftvleqvtqredevthniasqnkdknRltqilvpdnyrvllk.......................gehpdyinavfidgykekkafiiaesP

IPATMNIFWRMVFEQGVSAIVVLTRELEAGRLRCHRYWPEEGQsTIYADITVTTTAWREQPRSARRTLRLERPG--CEPRRIEQLLFTAWPETG-VPADP
.  |.  ||... .. |.|||.|..| |  .  |..|||||   ... . ... .    .     |.|.... .   ......|  .|.|..|| |.   
mfntarnfWkliddrnvtaivmlcqekendeevcyqyWpeeks.vvlGeyniellneevnagyierklevknknkagdkqqvkqyqitnWdstgkvtepq

NAFLDFHREVQQcTRPNGNltAPMVVHCSSGVGRSGCFVAFDRLAQSAaRQLTPLSVKATILSLRHERMLMVQTVLQYEFVYKAVLRYLDL
  .| ... ...  | .||  ...||||| .||||. |.| .   . . ..   . |   . | |  .. .|||| ||.|....|| ||| 
tillvieemykt.qrkrgn..tsivvhCsdtvGrsamfcaaattinkc.kteGviDvfqvlksqriqkpgsvqtveqykfindivleylds
subfamily_PTPRN_pd Subfamily PTPRN 663-947 2.6e-46 152.7 In-house 25-290 (297) alignment 
Range on Protein: 663-947
Range on HMM: 25-290/297.0
LQRNDGLQSEFATIEAADVR-NTSVAAKRDANTHKHRYSNIFAYDHTRVRVTPDDAAlrsdpapNgdlttdegldviNTDYIDANFIAGVSG-KAEYIVT
|. .| |. |. .. | .   .|. .||.. | .| |......|||.||... . .|       .            ..|||.| .|      .. || |
lknkdrlekewealcayeaepstkevakaeknvkknrskavlpydhsrvklkeeasa.......e............ksdyinasaildhdprapayiat

EAPIPATMNIFWRMVFEQGVSAIVVLTRELEAGRLRCHRYWPEEGQST--IYADITVTTTAWREQPRSARRTLRlERPGCEPRRIEQLLFTAWPETGVPA
..|...|.  ||.||.||||  || |||  | |  .|.||||.||...  ||    |.   | ..       |. .    | | . |. | .|||.||||
qgplastvadfwqmvweqGvvvivnltrleeegvkqckrywpdeGsevyhiyevhlvsehiwcddylvrsfylk.nlqtsetrtvtqfhflswpeegvPa

DPNAFLDFHREVQQCTRPngnLTAPMVVHCSSGVGRSGCFVAFDRLAQSAARQLTPLSVKATILSLRHERMLMVQTVLQYEFVYKAVLR
 ....|.| | |... |     ..|.|||||.|.||.|.... | . .  .. .  . . ||.  || .|  .|.|  |.||...|| .
saksllefrrkvnksyrG...rscpivvhcsdGaGrtGvyilidlvlnrllkGvkeidiaatlehlrdqrpglvktkdqfefaltavae
subfamily_PTPN13_pd Subfamily PTPN13 740-949 2.6e-46 153.1 In-house 60-269 (273) alignment 
Range on Protein: 740-949
Range on HMM: 60-269/273.0
TDYIDANFIAGVSGKA--EYIVTEAPIPATMNIFWRMVFEQGVSAIVVLTRELEAGRLRCHRYWPEEGQSTIYA--DITVTTTAWREQPRSARRTLRLER
. ||.|..|    ||   |||..  |.| |.. ||.||.|| .. |...| | | |...|||||||. .... .   ..|.     ..   . |.| .. 
ggyinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweqkaeviamvtlekekgkvkchrywPesknkklkvsnrlevellkvqkldgfvvralavkd

-PGCEPRRIEQLLFTAWPETGVPADPNAFLDFHREVQQCTRpngnLTAPMVVHCSSGVGRSGCFVAFDRLAQSAARQLtPLSVKATILSLRHERMLMVQT
    | |.. .| |..||. |||. .. .| | .||..  .     ..|.|||||.|.|||| ... | . .  .|.  .. || .. .||. |  .|||
sesgesrevahlnfvkwPdhgvPssaaellqfvaevrrlqt....dagPivvhcsaGiGrsGtlitidvvlglierdk.efdvkeivrklreqrqgvvqt

VLQYEFVYKAVLRYL
  || |||||.|  |
kdqyifvykailevl
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 672-950 3.7e-46 152.3 In-house 23-277 (515) alignment 
Range on Protein: 672-950
Range on HMM: 23-277/515.0
EFATIEAADVRNTSVaAKRDANTHKHRYSNIFAYDHTRVRVTpddaALRSDPapngdlttdegldviNTDYIDANFIAGVSGKAEYIVTEAPIPATMNIF
||  .   ..   .| |. . | .| || ||. || .||..      .  .|               . ||..| .| ..     || . .| .|... |
efhdlpgpniypqtv.aqeeinfkknryknilPydsvrvkle....vindnP...............hsdyfnasyipsfdndkayiasqgPnkasvddf

WRMVFEQGVSAIVVLTRELEAGRLRCHRYWPE-EGQSTIYADITVTTTAWREQPRSARRTLRLERpGCEPRRIEQLLFTAWPETGVPADPNAFLDFHREV
||.|... |..|...|.  |  . .| .|||.  |.|  .  | | . .        .|.|.. . | . | . |  || ||. ||| . ...| . .||
WrlvlqenvttiamvtklkegdkikcgkyWPdkpgdsvkfGsikvelvsleactggikrkltvlk.gddsrtvtqfhfteWPdkGvpkhtssllklikev

QQCTrpnGNLTAPMVVHCSSGVGRSGCFVAFDRLAQSAArQLTPLSVKATILSLRHERMLMVQTVLQYEFVYKAVLRYLD
.  .   |..| |...|||.|||| | ... |     |. .   . |  ..  .| .|. .|||  || |.| ||| .| 
kadh...gqythpliihcsaGvGrtGvvisidsvvahak.ttrmvdvfnfvtnirqkrpylvqtqeqyafiygavledll
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 662-950 2.2e-45 149.8 In-house 15-284 (290) alignment 
Range on Protein: 662-950
Range on HMM: 15-284/290.0
DLQRNDGLQSEFATIEAADVRNTSVAAKRDANTHKHRYSNIFAYDHTRVRVTPddaalrsDPApNGDlttdegldvINTDYIDANFIAGVSGKAEYIVTE
  . |.| ...| ......  .|   .    | .. |..||  ||  |. . |        .  . |          . .||.| .| | . | .||.|.
hakgnegfrnqfkmldsgesehtvtvgltssnkllnRfanivvyddnritLrp.......isg.hkD.........CtneyinAcyikgykekkqyiatq

APIPATMNIFWRMVFEQGVSAIVVLTRELEAGRLRCHRYWPEEGQSTiYADITVTTTAWREQPRSARRTLRLERPGC--EPRRIEQLLFTAWPETGVPAD
.|.. |.  ||... .. |..||.|| . | |. .|. |||...... |  .... .  ..  .  .|.|...      ... . |. .|.|..||  ..
gpvsntlvdFWkliwqekvtiivmltniieegkvkCqqYWpdsdtka.ygefsikllneetlneyierklevknknsagakqsvtqyqitnwdstgkvtn

PNAFLDFHREVQQCTRPNGNltAPMVVHCSSGVGRSGCFVAFDRLAQSAaRQLTPLSVKATILSLRHERMLMVQTVLQYEFVYKAVLRYLD
|.. |   .|...  | .||   ..||||| .||||. |.| .   . . ..     | . . |.|  .. .|||| ||..... ||.|||
pqtillvieemyktqrkrgn..tsivvHCSdtvgrsavfcaaattinkc.ktegvidvfqvlksqRiqkpgsvqtvqqyqgifqivltyld
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 663-951 3.7e-45 148.9 In-house 6-279 (287) alignment 
Range on Protein: 663-951
Range on HMM: 6-279/287.0
LQRNDGLQSEFATIEAAD--VRNTSVAAKRDANTHKHRYSNIFAYDHTRVRVTpddaalrSdpapngdlTTDEGldvinTDYIDANFIAGVSGKAEYIVT
.. .| .. |. ..      .  |  ||.  |...| ||.... .|.||| ..                ... |     .|||.||..|.   . ..|..
rrvkddvdkevdalkedsesstatfkaaeelaavkknryadvlPiddtrvlls.......a........egelG.....sdyinanyvasytddeafiaa

EAPIPATMNIFWRMVFEQGVSAIVVLTRELEAGRLRCHRYWPEEGQSTIYADITVTTTAW-REQPRSARRTLRLERP-GCEPRRIEQLLFTAWPETGVPA
 .||.||.. |||.|.|. .......|||.| .||.|..||||  .       .|.       .|  . |.|||    . | | ..|| . .||. ... 
qgPiaatvrdfwravletrsasvitmtreveearlkcykywPerevPmrvGGysvvlldydikePeygvralrlidletrearvvkqldllswPdkvlaP

DPNAFLDFHREVQQC--TRPNGNLTAPMVVHCSSGVGRSGCFVAFDRLAQSaARQLTPLSVKATILSLRHERMLMVQTVLQYEFVYKAVLRYLDL
   ... |  .|.|    . ... . |.|||.. |.|||| ..|   | .    .|  . | |... ||  |  .||.|.|. ..|.|.  |   
tavglirfvldvkqhielardasevGPlvvhddvGiGrsGillatlvlvsr.ledlGrvdvaavvirlreyraalvqavvqlrllyealvtyykt
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 662-951 1.7e-44 147.3 In-house 18-295 (325) alignment 
Range on Protein: 662-951
Range on HMM: 18-295/325.0
DLQRNDGLQSEFATIEAADVRNTSVAAKrDANTHKHRYSNIFAYDHTRVRVTpddaALRSDPapngdlttdegldviNTDYIDANFIAGVSGKAEYIVTE
  | .||.  ||  . . |     ||.|  .|  | |. |. |.|..|| .     ... ||               ..|||.|...    .|  .. . 
kaqdqdgfahefgllpsddgiakkvamk.penkaknrfknvvaldksrvvle....tkkddp...............ssdyinasylrddkkkdvflaaq

APIPATMNIFWRMVFEQGvSAIVVLTRELEAGRLRCHRYWPEE-GQSTIYADITVTTTAWREQPRSARRTLRLERP-GCEPRRIEQLLFTAWPETGVPAD
|| .||.| .||.|..   ...||.. ||. |  ||  |||.| |.|  .  . |   .  |      | | . .. . | | ..|. . .|.. ||.  
aPltatindlWrlvldWr.csvvvvlneldlgkdrcavywpkemgksktfGglevklrtieeisdyvhrvldvkqvkkGetrsvkqfqlqswddmGvqkr

PNAFLDFH---REVQQCTRPNGNLTAPMVVHCSSGVGRSGCFVAFDRLAQSAARQlTPLSVKATILSLRHERMLMVQTVLQYEFVYKAVLRYL-----DL
| ... .     .|... . | . ..|..||||.||||.| |...  ...    . . . .   .  ||..|  ||.|| || ..|.|.  ..     |.
patlisilqlvkavservtantkastpilvhcsaGvGrtGvfislysalakviee.srvdifgfvkklrkdrpsmvetvdqyiliyealveaymsgntdv
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 650-947 5.2e-44 145.8 In-house 19-289 (319) alignment 
Range on Protein: 650-947
Range on HMM: 19-289/319.0
ELQQNALRQHFQDLQRNdgLQSEFATIEAADVRNTSV-AAKRDANTHKHRYSNIFAYDHTRVRVTPDDaalrsdpapngdltTDEGldvinTDYIDANFI
. || . ...|.| ...  |. ||  .    |  .    |  | |  | |. ||.|.|...|.. . .                |.     .|||.| |.
yyqqlsnksdfdddltk..levefrracklgvnladqtfanldqnkdknriinilafdknvvklerli..............Geef.....sdyinasfv

AGVSGKAEYIVTEAPIPATMNIFWRMVFEQGVSAIVVLTreleagRLRCHRYWPEEGQSTiYADITVTTTAWREQPRSARRTLRLERPG--CEPRRIEQL
.|   |  || .  | . |.. ||||..|. .|.||.||      . .| .||| ... . .    |  ..  |    . | ..| . |   . |.| | 
tGyqrkdkyiaaqGPldntladfWrmiweyncstivllt......kdkcsqywplkivik.eerfkvkvdsveetaeyvvrdielsedgkekdirkitqf

LFTAWPETGVPADPNAFLDFHREVQQCTRpNGNLTAPMVVHCSSGVGRSGCFVAFDRLAQSAaRQLTPLSVKATILSLRHERMLMVQTVLQYEFVYKAVL
 |  ||. |||  |  .. . . |.  |.   |  |..|||||.||||.| ....| | .   ..   . |  ..  || .|  .|| . || |.| |.|
hflGwpdvGvpdypsdlmrlvkkvrhlts.kenhranivvhcsaGvGrtGvyivldvlldrm.keekqvdvynfvrdlrqqrntlvqdlvqykfiysall

R
 
e
subfamily_PTPN1_pd Subfamily PTPN1 738-947 2e-42 139.9 In-house 54-269 (290) alignment 
Range on Protein: 738-947
Range on HMM: 54-269/290.0
INTDYIDANFIAGVSGKAEYIVTEAPIPATMNIFWRMVFEQGVSAIVVLTRELEAGRLRCHRYWPEEGQ--STIYADITVTTTAWREQ--PRSARRTLRL
 ..|||.|...     | .||.|  |.| |.. ||.||.||   |.|.| . .| ....|..|||.. .  . .. |.... .  .|.      .|.|.|
adndyinaslveleeakrsyiltqGPlpntvdhfWqmvWeqkskavvmlnkvvekeqikcaqywPqgeeekellledtklkvkliseerksyytvrllel

ER-PGCEPRRIEQLLFTAWPETGVPADPNAFLDFHREVQQCTRPNGNlTAPMVVHCSSGVGRSGCFVAFDRLAQ--SAARQLTPLSVKATILSLRHERML
|     | | | .  .|.||. |||  |.|||.|  .|...   . .   | |.|||.|.|||| |.  | .     .  .|. . .| ..| ||. |. 
enlktqetreilhfhyttwpdfgvpespaaflkflfkvresGslssd.vGpavihcsaGiGrsGtfclvdtclvliekkddlssvdikkvllelrkyrlG

MVQTVLQYEFVYKAVLR
..||  | .| | |.| 
liqtadqlrfsylaile
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 687-947 8.6e-42 138.6 In-house 19-253 (284) alignment 
Range on Protein: 687-947
Range on HMM: 19-253/284.0
AAKRDANTHKHRYSNIFAYDHTRVRVTPDDaalrsdpapngdltTDEGldvinTDYIDANFIAGVSGKAEYIVTEAPIPATMNIFWRMVFEQGVSAIVVL
 |  | |  | |. .|.|.|...|.. . .                |.     .|||.| ||.|   |  || |  | . |.. ||||..|. .|.||.|
fanldqnkdknrighilafdknvvklerli..............Geef.....sdyinasfitGyqrkdkyiatqGPldntladfWrmiweyncstivll

TreleagRLRCHRYWPEEGQSTiYADITVTTTAWREQPRSARRTLRLERPG--CEPRRIEQLLFTAWPETGVPADPNAFLDFHREVQQCTRpNGNLTAPM
|      . .| .||| ... . .    |  ..  |    . | ..| . |   . |.| |  |  ||. |||  |  .. . . |.  |.   |  |..
t......kdkcsqywplkivik.eerfkvkvdsveeseeyvvrdielsedgkekdirkirqfhflgwpdvgvpdypsdlmrlvkkvrhlts.kenhrani

VVHCSSGVGRSGCFVAFDRLAQSAaRQLTPLSVKATILSLRHERMLMVQTVLQYEFVYKAVLR
|||||.||||.| ....| | .   ..   . |  ..  || .|  .|| . || |.| |.| 
vvhcsagvgrtgvyivldvlldrm.keekqvdvynfvrdlrqqrntlvqdlvqykfiysalle
subfamily_CG7180_pd Subfamily CG7180 739-949 4.7e-40 132.1 In-house 69-290 (296) alignment 
Range on Protein: 739-949
Range on HMM: 69-290/296.0
NTDYIDANFIAGVSGKAEYIVTEAPIPATMNIFWRMVFEQGVSAIVVLTRELEAGRlRCHRYWPEEGqSTIYADITVTTTAWREQPRSARRTLRLERP--
..|||.| .. .   |.||||||||   |.. |||.|.....||.||||.. .  .  .. |||...  . | .| | ..  .. .    ||..| .   
ksdYinavyvdsflkkkeyivteapkketvdefWrlvydeeisavvvLtktfdfak.mypsywpnks.keqygeifveiveekqyanlkirtfkltkkiv

---------GCEPRRIEQLLFTAWPE-TGVPADPNAFLDFHREVQQCTRPN--GNLTAPMVVHCSSGVGRSGCFVAFDRLAQSAaRQLTPLSVKATILSL
           | | . .. .| |.    ||   ||.... | |..  . .   . ..|.||..| |..||| ..| |   . . ..   . |   .  |
alteqekqvkaetRivklfqlteWeledkvPlstnalielrrrvrlwrekvdedpeegPvvvvssdGasRsGvylaidanlelv.ekeeevdvFeavktl

RHERMLMVQTVLQYEFVYKAVLRYL
|..|  .|..| .| ..|  .| ..
rrsRpqLvenveeYkyiYdvlleav
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 693-946 1.1e-39 131.0 In-house 3-236 (237) alignment 
Range on Protein: 693-946
Range on HMM: 3-236/237.0
NTHKHRYSNIFAYDHTRVRVTPDDAAlrsdpapngdlttdegldvinTDYIDANFIAGVSGKA-EYIVTEAPIPATMNIFWRMVFEQGVSAIVVLTRELE
|  | ||.|| ||||.|| .    ..                     .|||.|... |. |   .|| .. |. .. . ||.||...  | ||.||  .|
nkiknrygnivaydhsrvvlkgagsg.....................sdyinatylkgfdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltglie

AGRLRCHRYWPEEGQSTIYADITVTTTAWREQPRSARRTLRLERPGC--EPRRIEQLLFTAWPETGVPADPNAFLDFHREVQQCTRpNGNLTAPMVVHCS
  .|.||.|||.  | . |  .||. .   |    . |.| | . .   | | | |  ||.||. |||    |.| | ... . ..   . ..| ..|||
gnelkchkywpstdqpaaygvltvslkkkeefsdytvrslllskrltlkevrlihqyqftswpdrgvpqqtaallrfrkniinrsp.hvsesgpwiihcs

SGVGRSGCFVAFDRLAQSAaRQLTPLSVKATILSLRHERMLMVQTVLQYEFVYKAVL
.||||.| |.  | . . | ..   . .   . |.  .|  ..||  || |.....|
agvgrtgiflvidamlrqa.kekkvvdiynyvysieedrpyiiqtkdqyvfihqtil
0041856 (Phosphotyrosine protein) phosphatases II 693-949 2.1e-37 123.8 In-house 1-171 (182) alignment 
Range on Protein: 693-949
Range on HMM: 1-171/182.0
NTHKHRYSNIFAYDHTRvrvtpddaalrsdpapngdlttdegldviNTDYIDANFIAGVSGKAEYIVTEAPIPATMNIFWRMVFEQGVSAIVVLTrelea
| .|.|||.|. |||.|                             . ||| ||...|     ..|.| .| . |.. |.||. |.|...|| ||     
nldknrysdilpydhsr.............................dldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt.....

grlrCHRYWPEEGqstiyaditvtttawreqprsarrtlrlerpgcePRRIEQLLFTAWPETGVPAdPNAFLDFHREVQQctrpngnLTAPMVVHCSSGV
    ...||||.                                   .| . |.|.. ||  |||  .. .||| .||..          | .|||| ||
....eelywpell..................................erlgiqylylpwpDhgvpd.ldelldfieevle.......eggpvlVHCsaGv

GRSGCFVAFDRLAQSaarqltPLSVKATILSLRHERMLMVQTVLQYEFVYKAVLRYL
||.|..|| . . .        .|.  ..  .|  |. ||.|  || |.. |.| .|
gRtgtlvaaylmkkl......gvsleeavklvrsrRpgmvitpnqyfflqlallell
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 652-948 2.8e-37 123.2 In-house 3-278 (439) alignment 
Range on Protein: 652-948
Range on HMM: 3-278/439.0
QQNALRQHFQDLQRNDG--LQSEFATIEAADVR---NTSVAAKrDANTHKHRYSNIFAYDHTRVRVtpddaalRSDPapngdlttdeglDVINTDYIDAN
... ...| ..|..|.   .. .| .|....     ..|.||. . .  | || .. |.||||| .       .  |             |  . ||.||
grdefqehvekldknkqeifkeifekinstspdyaciaslaaq.eydqtknrykdvgafdhtrvtl.......qeip............gvphshyinan

FIAGVSGKAEYIVTEAPIPATMNIFWRMVFEQGVSAIVVLTRELEAGRlrchrYWPEEGQsTIYADITVTTTAWREQPRSARRTLRL--ERPGC-EPRRI
.| |   .  || |..|   | . |||.|.|. .. ||.||  .|. .     ||| ... ..| ||.| .    | |. . | ...  ||  .   | .
yikGyyddklyiatqgpkkettddfwrlviekktvtivmltnlvesyk.....ywpsdae.vcygdiavrvdrnielpnyvirgfkvfnerdttekertv

EQLLFTAWPETGVPADPNAFLDFHREVQQCTrpNGNLTAPMVVHCSSGVGRSGCFVAFDrLAQSAARQLTPLSVKATILSLRHERMLMVQTVLQYEFVYK
 |. ..|||.  |||.    ||| | .. .   . . . |.|||||.||||.|  .|.| .|    .    . .|  .  ||..|  |||.. || |.|.
lqfhyiawpdknvpaqashvldflrainsan..dkeeygpvvvhcsagvGrtGtiiald.ialeqlklenkvdikgivkvlrkqrkqmvqalcqyvfiyn

AVLRY
|||  
avled
0051429 (Phosphotyrosine protein) phosphatases II 740-952 3.9e-37 123.7 In-house 4-228 (272) alignment 
Range on Protein: 740-952
Range on HMM: 4-228/272.0
TDYIDANFIAGVSG---KAEYIVTEAPIPATMNIFWRMvFEQGVSAIVVLTRELEAGRLRCHRYWP-----------EEGQSTIYADITVTTTAWREQPR
..|| |... |  .   .  .. . .| |.| . |||.  |.|...|| |..| | ||| |.||||           .. ..  | ...||.. .  .. 
sgyiNardvggygrvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseellld

SARRTLRLERP--GCEPRRIEQLLFTAWPETGVPADPnaFLDFHREVQQctrpngnlTAPMVVHCSSGVGRSGCFVAFDRLAQSAARQ-------LTPLS
   |.|.|..     |.|.. .|..|.||  ||| ..  .|.. .....          |..||||.|..|.|..|| ..|..   ..       || | 
yilrellltlllsagearevmhlhytdwpdhgvpqea..llellellld........ggpvlvHCsaGkdRTGtvvallllllgvsletivddYlltnly

VKATILSLRHERMLMVQTVLQYEFVYKAVLRYLDLE
. ...  ||  |. .|||  ||.|.|.|.| .|.  
leeaveelraqrpgavqteeqylflyeallellrsl
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 669-949 1.8e-35 117.1 In-house 22-236 (392) alignment 
Range on Protein: 669-949
Range on HMM: 22-236/392.0
LQSEFATIEAADVRNTSVAaKRDANTHKHRYSNIFAYDHTRVRVTPDDaalrsdpapngdlttdeglDVINTDYIDANFIAGVSGKAEYIVTEAPIPATM
. .||  .   |. ...|| ... | .| || ||. || .||..   |                   |. ..||..| .| ..  .  || ...| .|..
ffeefhdlpgpdiypqtva.qkeinlkknryknilpydsarvklevid...................dipdsdylnasyipsfdnekayiasqgpnaasl

NIFWRMVFEQGVSAIVVLTRELEAGrlrchrywpeegqstiyaditvtttawreqprsarrtlrlerPGCEPRRIEQLLFTAWPETGVPADPNAFLDFHR
. ||||||.. |..|...|.  |.                                            | . | . |  || ||. .||   ...| | .
ddfwrmvfqenvttiamvtklkegd..........................................kgddartvaqfhftewPdkdvpkhtssllkfik

EVQQctrPNGNLTAPMVVHCSSGVGRSGCFVAFDRLAQSaARQLTPLSVKATILSLRHERMLMVQTVLQYEFVYKAVLRYL
||.      |. | |...|||.||||.|  .. | .    |..   . |   .  .|..|  ||||  || |.| |||  |
evka...dfGqythpliihcsagvgrtgvvisidsvvah.akktrmvdvfnfvtnirrkrpymvqtkeqyafiygavledl
0046846 (Phosphotyrosine protein) phosphatases II 737-949 5.6e-35 116.0 In-house 9-173 (176) alignment 
Range on Protein: 737-949
Range on HMM: 9-173/176.0
VINTDYIDANFIAGvsgkAEYIVTEAPIPATMNIFWRMVFEQGVSAIVVLTRELEAGRLRCHRYWPEEGQSTIyaditvtttawreqprsarrtlrlerp
  . |||.||.|.|    . .|.| .|.| |.  |..|..|.|..|.| || | | |||.|..||||. .  |                           
dldldyinanlilg....srpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgi...........................

gceprrieQLLFTAWPETGVPADpNAFLDFHREVQQCTRPNgnltAPMVVHCSSGVGRSGCFVAFDRLAQSaarqlTPLSVKATILSLRHERM-LMVQTV
        | |.. ||. ||| . ...|.. ...... . .     | .|||| |.||.|..|| . |  .       |||  ..  .|  |.  .||| 
........qylhlpwpDhgvpdl.elllellefirealkeg....gpvlVHCsaGigRtgtlvaayllele.....kglsveealalvreqRplgavqtp

LQYEFVYKAVLRYL
 ||.|.|...|..|
eQyrflyefellll
0036282 (Phosphotyrosine protein) phosphatases II 740-943 8.2e-35 115.4 In-house 2-164 (174) alignment 
Range on Protein: 740-943
Range on HMM: 2-164/174.0
TDYIDANFIAGVSGKAEYIVTEAPIPatmniFWRMVFEQGVSAIVVLTRELEAGRLRCHRYWPEegqstiyaditvtttawreqprsarrtlrleRPGCE
.|||.|... ..    ..|.. .| .     ||.|..|.|....| |..| | |. .|..||||                               ..  .
sdyinaspldlsyitprliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe...............................lredl

PRRIEQLLFTAWPETGVPADPNaFLDFHREVQQCTRPngNLTAPMVVHCSSGVGRSGCFVAFDRLAQSAArqLTPLSVKATILSLRHERMLMVQTVLQYE
 | . |.|.. ||  ||| ..  .|.| ..|...     .   |..|||| ||||.|..|| ... .      ..  . ... .||  |. ||||  ||.
erlgiqylylpwpDhgvpdlsi.llefvkfveealse..dpggpvlVHCsaGvgRtGtlvaaylmlrgll..eslvdaldlvrelRlqrpgmvqtpsQyr

FVYK
|.|.
flyy
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 675-947 1.3e-34 114.4 In-house 14-264 (283) alignment 
Range on Protein: 675-947
Range on HMM: 14-264/283.0
TIEAADVRN-TSVAAKRDANTHKHRYSNIFAYDHTRVRVTPDDAalrsdpapngdlttdegldvintDYIDANFIA---GVSGKAEYIVTEAPIPATMNI
...   | .  .. |  | | .| |. .| ..|  ||.. ..                         |||.| ||        . .||.. .|.  |.  
vlkrlsvpdldadiasadenkrknrnqeivpadqwrvelksesr.......................dyinavfipvsksykqdkkyiiaqsPldrtvvd

FWRMVFEQGVSAIVVLTRELEAGRLRCHRYWPEEGqSTIYADITVTTTAWREQPRSARRTLRLERPGC--EPRRIEQLLFTAWPETGVPADPNAFLDFHR
||.|||.. ..|||.||.  |  | .| .|||..| |  | . |||      .    .. | |   .   .   .    .  | | |  |  |... | .
fWkmvfdekitaivmltklqedlrikCsqyWPkrG.sedyGeftvtlrkettsnsfiikelllrvnssakstlllahyqvidWleygeqaiinslvkfnk

EVQQCTRpngNLTAPMVVHCSSGVGRSGCFVAFDRLAQSaARQLTPLSVKATILSLRHERMLMVQTVLQYEFVYKAVLR
 . . |.   .  .|.|||||.|.||.. |.|     .  |.  . . | |..  .| .|| .|||  || .|...|| 
vislqte...skkgPivvhCstgiGrtavfiaasasvkd.altesvvdvfavvkimreqrmmavqtldqyklvhelvle
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 687-946 3.3e-34 113.1 In-house 2-238 (239) alignment 
Range on Protein: 687-946
Range on HMM: 2-238/239.0
AAKRDANTHKHRYSNIFAYDHTRVRVTpddaALRSDPapngdlttdeGLDVINTDYIDANfiaGVSGKAeYIVTEAPIPATMNIFWRMVFEQGVSAIVVL
|||.  |  | ||.|| .|||.|| .      |  ||            | ||. |.        | || || |.  . ..   ||||....    ||.|
aakkrvnkaknryanivtydhsrvvle....klsndp..........hsdyinasylrdy...dgspka.yiatqgcveissgdfwrmmwqerrcvivml

TRELEAGRLRCHRYWPEEgqSTIYADITVTTTAWREQPRSARRTLRLERPG-CEPRRIEQLLFTAWPETGVPADPNAFLDFHREVQQCTRPNgnlTAPMV
|  .|  . .||.|||.   .. |... ||            ||. . . |  | | . |  || ||. |||    | | ..|.. . . |    . | |
tglieghkkkchqywpds..tskycnlrvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrkitkdslpg...arpwv

VHCSSGVGRSGCFVAFDRLAQSAARQLTpLSVKATILSLRHERMLMVQTVLQYEFVYKAVL
.|||.||||.|.|.  | . . | .| | . .   . ..| .|  ||||  || |.. |||
ihcsagvgrtgaflvidamlrqakkqkt.vdifnyvkairedrphmvqtseqyvfihlavl
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 687-946 3.7e-34 112.9 In-house 1-237 (239) alignment 
Range on Protein: 687-946
Range on HMM: 1-237/239.0
AAKRDANTHKHRYSNIFAYDHTRVRVTpddaALRSDPapngdlttdeGLDVINTDYIDANfiaGVSGKAeYIVTEAPIPATMNIFWRMVFEQGVSAIVVL
|||.  |  | ||.|| .|||.|| .      |  ||            | ||. |.        | || || |.  . ..   ||||....    ||.|
aakkrvnkaknryanivtydhsrvvle....klsndp..........hsdyinasylrdy...dgspka.yiatqgcveissgdfwrmmwqerrcvivml

TRELEAGRLRCHRYWPEEgqSTIYADITVTTTAWREQPRSARRTLRLERPG-CEPRRIEQLLFTAWPETGVPADPNAFLDFHREVQQCTRPNgnlTAPMV
|  .|  . .||.|||.   .. |... ||            ||. . . |  | | . |  || ||. |||    | | ..|.. . . |    . | |
tglieghkkkchqywpds..tskycnlrvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrkitkdslpg...arpwv

VHCSSGVGRSGCFVAFDRLAQSAARQLTpLSVKATILSLRHERMLMVQTVLQYEFVYKAVL
.|||.||||.|.|.  | . . | .| | . .   . ..| .|  ||||  || |.. |||
ihcsagvgrtgaflvidamlrqakkqkt.vdifnyvkairedrphmvqtseqyvfihlavl
0043147 (Phosphotyrosine protein) phosphatases II 740-942 2.4e-32 107.4 In-house 5-154 (172) alignment 
Range on Protein: 740-942
Range on HMM: 5-154/172.0
TDYIDANFIAGVSGKAEYIVTEAPIPATMNIFWRMVFEQGVSAIVVLTREleagrlrchrywpeegqstiyaditvtttawreqprsarrtlrLERPGCE
.|||.|... ..    ..|.| .| . |.. ||||. |.|...|| ||..                                           |  | ..
sdyinasyldlyyipdrfiatqgplrntladfwrmlkelgithivnltel...........................................lydpell

PRRIEQLLFTAWPETGVPaDPNAFLDFHREVQQ--CTRPNgnltAPMVVHCSSGVGRSGCFVAFDRLAqsaarqlTPLSVKATILSLRHERMLMVQTVLQ
 | . |.|.. ||  ||| ... .|.| . ...  . .|.     |..|||| ||||.|..|| . .          ||.  ..  .|. |. .||.  |
erlgiqylylpwpDhgvp.llellleflefidellalspg....gpvlVHCsaGvgRtgtlvaaylml.......lglsleeavalvrekRpgavqnpsq

YEFVY
| |.|
yrfly
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 664-952 7.2e-32 105.3 In-house 12-296 (301) alignment 
Range on Protein: 664-952
Range on HMM: 12-296/301.0
QRNDGLQSEFATIEAADVRNTSVAAkRDANTHKHRYSNIFAYDHTRVRVTPddaalrsdpapngdlttDEGLDVINTDYIDANFIAGVSGKAEYIVTEAP
.......... ... .. ....|   ...|..  |. ||  ||. |. ..|                  . ||. ...||.|..| |.| | ..|....|
khsnkfeeqykelkegedksctvgl.seenkalnrfknitvyddnriilkp.................kpnldlcqreyinasyidgysekkkfiaaqgp

IPATMNIFWRMVFEQGVSAIVVLTRELEAGRLRCHRYWPE-EGQSTIYADITVTTTAWREQPRSARRTLR-----------------LERPGcEPRRIEQ
.  |.  |||..... ...||..| . |  . .|..|||. | .|. .  .||| .     |    | |                   ..   ... . |
mkktlvdfWrliwqekpvsivmvtnlkegtkskceqywpnseaeseefgpftvtlvneqvyPdfvirqlnvkiqdgsnngyierkfkvksdk.sswdvlq

LLFTAWPETGVPADPNAFLDFHREVQQCTRPNGNltAPMVVHCSSGVGRSGCFVAFDrLAQSAARQLTPLSVKATILSLRHERMLMVQTVLQYEFVYKAV
|  | ||. ||  .|.  |    .| . ..  |   .|.||||| .|.||| ... . ..   ..  .   |   . ..|. .. .|.|  || ..|...
lqvtdWpqdGvvreprtvLqviddvihrqqkigg..gpvvVHCSdtVsrsGvYcsvs.iglEQckaegVVdvfqvtkavrrskpgaVtTLeqytsiydvi

LRYLDLE
 .|| |.
dmylqln
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 736-948 3.6e-30 99.6 In-house 77-282 (290) alignment 
Range on Protein: 736-948
Range on HMM: 77-282/290.0
DVINTDYIDANFIAGVsgKAEYIVTEAPIPATMNIFWRMVFEQGVSAIVVLTRELEAGRLRCHRYWPE-EGQSTIYADITVTTTAWREQ-PRSARRTLRL
|  . ||. ||.. |.  || .|.|. .. .|.  .|||| ...|.|||.|   .| |. .|..|.|| ||.   . .|||. .   ..  .  ..|| .
dGydGdyvhanyvkGl..kamfiltqGalkdtvidiwrmvlqekvaaivmlceliedGkakceqyypekeGevltfGeitvlcseeddkdaniikktlsv

-ERPGCEPRRIEQLLFTAWPETGVPADPNAFLDFHREVQQctrpngnLTAPMVVHCSSGVGRSGCFVAFDRLAQSAArQLTPLSVKATILSLRHERMLMV
 ..      ..  |   .||.  |.    |.|   | ...       .. |.|||||.|.||.| ||| .  .|    .   | .  .. .||. |.  |
rdkdsGkehklkhlkikswpdksvalstlallrtlrilrk.......asGpvvvhcsaGiGrtGtfvaievglqill.dGkeldlldlvralrnsrlnsv

QTVLQYEFVYKAVLRY
|  .||  . ...| .
qvdiqylalveilldl
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 692-952 6.4e-30 99.2 In-house 42-274 (288) alignment 
Range on Protein: 692-952
Range on HMM: 42-274/288.0
ANTHKHRYSNIFAYDHTRVRVTpddaalrsdpapngdlttdeglDVInTDYIDANFIAGVSGKAEYIVTEAPIPATMNIFWRMVFEQGVSAIVVLTRELE
||. . || |..  | |||...                      |     || || ..    |   | ..||. .|....|.|..|..|  ||.|.. ||
anptrdryenlprcditrvkls......................ddp.dfyiaanvvssakykrrlicaqaPlngtieelWkmllesdveyivmlcelle

AGRLRCHRYWPE-EGQSTIY-ADITVTTTAWREQPRSAR-RTLRLERPGCEPRRIEQLLFTAWPETGVPADpnaFLDFhreVQQCTRPnGNLTAPMVVHC
 |. .   |.|   |... .    ||.     .  .  .  .|| ...| |.  . .| .  |.. ||| .   .| .   .. ...   .|. |.|||.
kGkeksaeyfPsklGekarigrlctvvkkkradidklvkvsllriskegeekvivkilhlleWdddgvPen...ylsp...lrllevl.kslqkPivvhs

SSGVGRSGCFvAFDRLAQSAARQLTPLSVKATILSLRHERMLMVQTVLQYEFVYKAVLRYLDLE
| ||||.| . ..  .|  ..|    |...  . .|| ||.  .||  || .|.. || .| | 
saGvGrtgtl.ililialeslrlddflgirsllaklreerfkaiqtemqylyvhrcvleelllk
0049260 (Phosphotyrosine protein) phosphatases II 748-943 8.8e-30 98.8 In-house 2-144 (152) alignment 
Range on Protein: 748-943
Range on HMM: 2-144/152.0
IAGVSGKAEYIVTEAPIPATMNIFWRMVFEQGVSAIVVLTRELEAGRLRCHRYWpeegqstiyaditvtttawreqprsarrtlrlerpgceprrieQLL
| |.  . |.| |..| | |.. ||||. |.|...||.||..|| |.| |..|.                                           | |
idgyampfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi...........................................qyl

FTAWPETGVPADPNAFLDFHREVQQCTRPNGNltaPMVVHCSSGVGRSGCFVAFDRLAqsaarqlTPLSVKATILSLRHERMLMVQTVLQYEFVYK
.. ||  ||| ..  .|.... .... . .|.   | .|||| ||||.|..|| . .          .|.. ..  .|  |. .|..  |..|.|.
hlpwpDhgvpdlsqlllflllfieklaldkgg...pvlVHCsaGvgRtgtlvaaylml.......lgvsleeavalvrekRpgavpnpgqlrflye
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 736-956 4.4e-29 96.4 In-house 63-283 (307) alignment 
Range on Protein: 736-956
Range on HMM: 63-283/307.0
DVINTDYIDANFIAGVSGKAEYIVTEAPIPATMNIFWRMVFEQGVSAIVVLTRELEAGRLRCHRYWP-EEGQSTIYADITVTTT-----AWREQPR---S
| . .||| ||..        .|... |  .|.  || |. .. | ....| . .| ....|..||| ||||  .... . | .     | .  |     
dglasdyihanylgiaikpkkficaqgplentqysfwamaiqekvesvimlckvielakikceqywpleegqklvfgeapntisvanlgakklapdedli

ARRTLRLERpGCEPRRIEQLLFTAWPETGVPADPNAFLDFhrevQQCTRPNgnlTAPMVVHCSSGVGRSGCFVAFDRLAQSAARQLTPLSVKATILSLRH
   ||...  . . | |..| .. ||. |||    . ...     . .| .   | |.|||||.||||||  ||   . .   .     ..|  .  || 
nvttlkvdw.aqksrtiqhlqwenwpdrgvpqinltainl....leavryd...tnpvvvhcsaGvGrsGtivaislvqdkmiaGinckdmkklveelrs

ERMLMVQTVLQYEFVYKAVLRYLdLELQKH
.|   .|| .|| .... .| |. ||| | 
qrhyaiqteaqylylhrvlleyf.lelyke
0051082 (Phosphotyrosine protein) phosphatases II 740-945 2.3e-28 94.1 In-house 3-149 (151) alignment 
Range on Protein: 740-945
Range on HMM: 3-149/151.0
TDYIDANFIAGVsgkaeYIVTEAPipatMNIFWRMVFEQGVSAIVVLTRELEAGrlRCHRYWPEEGqstiyaditvtttawreqprsarrtlrlerpgce
.|||..... |      .... .|    .. |.... |.|...|| |. | | |   |..|.||.|                                  
sdyinfsyvtgg.....lyrsggp....ladflellkelgiktivnlrseeerg..ycpeylpelg..................................

pRRIEQLLFTAWPETGVPADPNAFLDFHREVQQctrpngNLTAPMVVHCSSGVGRSGCFVAFDRLAQSaarqltpLSVKATILSLRHERMLMVQTVLQYE
 ... .. .. ||..|.|  ..|.|.|......      .   |..||||.|.||.|..|| .....        .|. ...  .|  |. .||.  |. 
.ievlhipildwpdpglplsfdavleflellld......kkngpvlvHCsaGkgRTGtlvalylmllg.......vsleealeeyrlkrpgvvqpnqqfl

FVYKAV
|...|.
fqlfal
PTPc_DSPc_SM00012 844-946 1.2e-27 91.5 In-house 3-104 (105) alignment 
Range on Protein: 844-946
Range on HMM: 3-104/105.0
EQLLFTAWPETGVPADPNAFLDFHREVQQCTRPNGNlTAPMVVHCSSGVGRSGCFVAFDRLAQSAARQLTPLSVKATILSLRHERMLMVQTVLQYEFVYK
 .. .|.||..||| .....|.. |.|..... ... ..|.||||| ||||.|.|||.| | |.  .. . .... .. .||..|. ||||  || |.|.
khyhytgwpdhgvPeesdsilellravkknknkses.skpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqylflyr

AVL
|.|
all
subfamily_ptpA1_pd Subfamily ptpA1 670-900 2.1e-27 90.9 In-house 24-248 (418) alignment 
Range on Protein: 670-900
Range on HMM: 24-248/418.0
QSEFATIEAADV-RNTSVaAKRDANTHKHRYSNIFAYDHTRVRVTpddaalrsdpapngDLTTDEGldvinTDYIDANFIAGVSGKaEYIVTEAPIPATM
. ||  .| .    .||    .  || | ||.||.  .||||..                .   ||     .|||.||.| |   | ..|.|. |.| |.
keefrlleesvgpsetse.gdkkhntsknrytnilpvnhtrvqlk..............kiqdkeg.....sdyinanyidgaypk.qfictqgplpnti

NIFWRMVFEQGVSAIVVLTRELEAGRLRCHRYWPEE---GQSTIYADIT-------VTTTAWREQPR--SARRTLRLERPGcEPRRIEQLLFTAWPETGV
  |||||.|. .  ||.|.|| |  |..| |||||.    | .|| .         |      ..|      | .||   | | | | |  .  ||.  .
adfwrmvwenrcriivmlsresencrikcdrywpeqiggeqfsiygngnevfgtysvelveviqdpereiitrnirltfeg.etrditqyqyegwpdhni

PADPNAFLDFHRE---VQQCTRPNGNLTAPMVVHCSSGVGRSGCFVA
|   . | .. .     |.   |. .   |..||||.||||.| |..
pdhtqpfrqllhsitnrqnqiipssdrnvpiivhcsagvgrtgtfct
subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 667-948 2.4e-27 90.3 In-house 11-268 (281) alignment 
Range on Protein: 667-948
Range on HMM: 11-268/281.0
DGLQSEFATIEAADVRNTSVAAKRDANTHKHRYSNIFAYDHTRVRVTpddaaLRsdpAPNGDlttdegldviNTDYIDANFIAGVSGKAEYIVTEAPIPA
| .. ||. .      .   . ..  | .| ||.|| . | .||..      ..    || .           |||| ||.|     |  ||.|. |   
ddfkqefsnlpgdppsdlctvfnqpvnnkknrylnipcldisrvqlk.....vk...mpnkn..........stdyihanyirspflkrgyiltqgpkke

TMNIFWRMVFEQGVSAIVVLTRELEAGRLRCHRYWPEEGQSTIYADITVTTTAWREQPRSARR-TLRLERpGCEPRRIEQLLFTAWPETGVPADPNAFLD
|   ||||....  .|||.| . ||. | .|  |.| . .  .  |    .       .|     | |     | | | . |.  ||.  ||   . .| 
tradfwrmiwqenttaivmlcqfletnrekcaeyfprnahcclqfdklsvsyedstvnkslvttrlnlsy.egetrlithwlwkewpdwqvpessevmlk

FHREVQQCtrpngnlTAPMVVHCSSGVGRSGCFVAFDRLAQSAARQLTPLSVKATILSLRH-ERMLMVQTVLQYEFVYKAVLRY
  |...         ..| |.|||.|||||| ..| .   ||   ..|   .|  .  ||   |   |||. || ...| .| .
ilrkirar.......stppvihcsagvgrsgtlmaveialqsihshftlpdikqivshlrvtgraasvqtlqqymliwkvlldf
0049772 (Phosphotyrosine protein) phosphatases II 683-951 3.3e-26 88.2 In-house 36-282 (314) alignment 
Range on Protein: 683-951
Range on HMM: 36-282/314.0
NTSVAAKRDANTHKHRYSNIFAYDhTRVRVtP-DDAalrsdpapngdlttdegldvINTDYIDANFIAGVsgkAEYIVTEAPIPATMNIF----------
.| ..|.  .| .| || .|. .| .||.. |  .                      ..|||.|... |.     .|.|..| . |.. |          
ltilvadlflnrdknryldilpad.nrvil.pglpv....................sgsdyinasyvdgf...lkfIatqgpleitvvdfreepvlyyng

WRMVF--EQGVSAIVV---------------------LTRELEAGrlrchRYWPEEGQSTIYaditvtttawreqprsarrTLRLERPGCePRRIEQLLF
||||.  .. |  ||                      |..  . |      ..... . ..                    .   ... . .|.. ..| 
wrmvlrgdlnvrdivmsrdevladelsrLdaAlgKtpllildgng.....neptaadlellk...................eelydpelf.erlgikylr

TAWPETGVPaDPNAFLDFHREVQQCtrpngNLTAPMVVHCSSGVGRSGCFVAFDRLAQSAarqltPLSVKATILSLRHERM-----LMVQTVLQYEFVYK
. .|  ..| ... |..| . ....     .   | .|||..|.||.|.||. . |          .|.. ..  .|  |.      .... .||||...
ipvpDgsap.lledfdeflefieea.....dkggpvlvHCkaGkgRtgtfvvaaylmkll.....gvsleealedvrlkRpinpnpgfieqleqyefile

AVLRYLDL
|.| ||. 
alleylkf
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 739-955 8.3e-26 85.3 In-house 79-294 (305) alignment 
Range on Protein: 739-955
Range on HMM: 79-294/305.0
NTDYIDANFIAG-VSGKAEYIVTEAPIPATMNIFWRMVFEQGVSAIVVLTRELEAGRLRCHRYWPEE-G-QSTIYADITVTT----TAWREQPRSARRTL
 .||| ||..   .  .  .|... |.  |.. || || .. |  ||.| . .| |.|.| .|||   | . .. . | |           ..     .|
psdyihanyvgcpmipekrficaqgpldqtidefwwmviqnkveqivmlcktvelgklkcaqywpaaqgeklelksgivvenvsgskpmerdaeiqitll

RLERPGCEPRRIEQLLFTAWPETGVPADPNAFLDFHREVQQCtrpngnlTAPMVVHCSSGVGRSGCFVAFDRLAQSAARQLTPLSVKATILSLRHERMLM
.|   | .   . .| .| ||. |||    . |..   ..           |.|||||.|.||.|  || . . .  | .     .   . .|| .|   
nltysgdqkmsvrhlqwtewpdrgvppckltslellsairgs.......kvpivvhcsagigrtgtivaieyilekiaenkpcppmpelvkalrdqrafs

VQTVLQYEFVYKAVLRYLdLELQK
.|. .|| |... .| |. ||  |
iqndvqylfihrvmlnyf.lekyk
subfamily_egg_pd Subfamily egg 687-948 8.5e-26 85.3 In-house 34-269 (307) alignment 
Range on Protein: 687-948
Range on HMM: 34-269/307.0
AAKRDANTHKHRYSNIFAYDHTRVRVtpddaalrsdPAPNGDLTTdegldvintDYIDANFIAGVSGKAEYIVTEAPIPATMNIFWRMVFEQGVSAIVVL
 |  | | .| |   .   | .||..            ..|  .          |.| || . |     |.|...||.  |.. ||||||.. |  ||.|
taasdnnlekarskrvhckdssrvkl..........elrrGqyld.........dfihanrvkGkpllnefilaqaplkntvddfwrmvfqeevqyivml

TRELEAgrLRCHRYWPEEGQSTIY---ADITVTTTAWREQPRSARRTLRLERPGCEprrIEQLLFTAWPetgvpADPNAFLDFHREVQqCTRPNGNLTAP
|   |.   ||. |||   . ..      . ...    ...    |  .|   | .    |..    |       | |   | .  ..   |   ||. |
tsrkes..erceyywpkaesdslvtvpGslrienlkvdskadplfrvtklklvGgd...deerflehwq.....gdvnnssdvysplr.vlrklrnlskp

MVVHCSSGVGRSGCFVAFDRLAQSAARQ-LTPLSVKATILSLRHERMLMVQTVLQYEFVYKAVLRY
.||..  || .....|| .    |  |  .|   |. ..  || .| | |..||.| |||. || .
vvvqdilGvskaatlvaieiallsllrGpitkslvlravvflrlrrrlsvesvllylfvyrlvlff
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 669-956 1.1e-24 81.9 In-house 8-266 (267) alignment 
Range on Protein: 669-956
Range on HMM: 8-266/267.0
LQSEFATIEA-ADVRNTSVAAKRDANTHKHRYSNIFAYDHTRVRVTPDDAAlrsdpapngdlttdegldvintdYIDANFIAGVSGKAEYIVTEAPIPAT
.. ||  |.  .| ..|        |  ..|. .   ||.||| .   .                         ||.| .. |   |  .|||. |.  |
iekefelikkisdtsstisqsiaeknqernrlddnlpyddtrvilrtkeee.......................yinasyvegyktknafivtqdplknt

MNIFWRMVFEQGVSAIVVLTRELEaGrlRCHRYWPEE-GQSTIYADITVTTTAWREQPRSARRTLRLERPGCEPRRIEQLLFTAWPetgVPADPNAFLDF
.  |. .. .|.|. ||.||.  . .    ...|| . ||.  | |.||  .  .|.      || |.      . .    .  |    . .. . .|  
itdfltvihdqkvpvivlltkvft.d..nirlfwPPkmgqakkyqdltvehslekeendyqiitlelkfknesahnvtlyyykkwn...intnnkpylkp

HRE-VQQCTRPNGNltAPMVVHCSSGVGRSGCFVAFDRLAQSAaRQLTPLSVKATILSLRHERMLMVQTVLQYEFVYKAVLRYLDLELQKH
    . .    |||   |.||.|| |||||| |.  |   . | ..   . .   .. .|. |. .|.|  .| .... .  | .  |.. 
lfgilaknqlengn..rPlvvacsdGvGrsGtflvidsqlera.ktegvsdifdflrkirsqriglvdtkeryiyihellaeyaegrlkee
0044763 (Phosphotyrosine protein) phosphatases II 735-948 1.3e-24 82.2 In-house 13-170 (178) alignment 
Range on Protein: 735-948
Range on HMM: 13-170/178.0
LDVINTDYIDANFIAGVsgkaeYIVTEAPIpatmNIFWRMVFEQGVSAIVVLTRELEAGRLRCHRYWPEEGQstiyaditvtttawreqprsarrtlrle
 ..  .|||.|..| .      .... .|       ..... |.|...|| || ||| |.| |..|||||                              
eglersdyinaseilpg.....lylgslpp....addlellkelgithivnlteelelgflkcdpywpeeag............................

rpgceprriEQLLFTAWPETGVPADPNAFLDFHREVQQCTRPNGnltAPMVVHCSSGVGRSGCFVAFDRLAQSaarqltPLSVKATILSLRHERMlMVQT
          | |.. .|  |||  .  ||.|.. ....  ..|    | .|||| ||||||..|| . . .        ||. . |  .|  |. .|..
.........iqylhipipDhgvpdllehflefvefieealdekg...gpvlVHCsaGvgRsgtlvaaylmkkl......glsleeaielvrerRp.ivpn

VLQYEFVYKAVLRY
  |....|.  ||.
pgqlrqLyefelrl
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 740-950 7.3e-24 79.0 In-house 73-288 (305) alignment 
Range on Protein: 740-950
Range on HMM: 73-288/305.0
TDYIDANFIAGVSGKAEYIVTEAPIPATMNIFWRMVFEQGVSAIVVLTRELEAGRLRCHRYWPEEGQSTIYA-----DITV----TT-TAWREQPRS--A
 .|| ||...  .    .| |.||.  |   || | ... | || .|   || |  .|. |.. . . ..        |.|    ..   .|.. ..   
heyihanyvstptnpkrfictqaplektcadfwymclqdkveaifmlcnllekgakkcleyfaskdkdvlefeekgqkisvkfessvtlkfrkdakakvt

RRTLRLERPGCEPRRIEQLLFTAWPETGVPADPNAFLDFHREvqqcTRPNgnlTAPMVVHCSSGVGRSGCFVAFDRLAQ-SAARQLTPlSVKATILSLRH
.  | .| ||.. |.. .  .  ||. ||||  .| |..  .    .||      |.|||||.|.||.|  | .. . .   | |      .  .  .| 
etvlviegpgekarkvthyhwidwpdrgvpaadlailellek....arps...kgpivvhcsagigrtgsvvmleyildqllagqiie.dtdkilqkire

ERMLMVQTVLQYEFVYKAVLRYLD
.|   .||  || ||.. .| |. 
qrnnsiqtdaqylfvhqvilnyfr
subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 645-950 9e-22 72.0 In-house 7-291 (310) alignment 
Range on Protein: 645-950
Range on HMM: 7-291/310.0
HHEYLELQQNALRQHfQDLqRNDGLQSEFATIEAADVRNTSVAAKRdANTHKHRYSNIFAYDHTRVRVTPDDAalRsdpapNGdlttdegldvintDYID
|..||.  .| .    . |   .||  ..  ..| .    .  | .  . || |||..   | .||... | .  |      .             ||| 
hlkylkalenfiiat.ekl.gieglvkqyrkldakqdssltyeayk.kymhknrysdvvcldtsrvklkidks..r.....ye.............dyih

ANFIAGVSGKAEYIVTEAPIPATMNIFWRMVFEQGVSAIVVLTRELEAGRLRCHRYWPEEGQSTIYADITVTTTAWREQP----RSARRTLR-----LER
||..     .. .|... |.  |.  ||||.|..   .|..| .  | || .|  |||  | .  |  | ||  .   .       |   .       |.
anyvktnylrstficsqgplqhtiidfwrmifqeraesilllckvgeegrpkcvgywpslgvtetygcirvtnlsesseefeicnlavtfvpdnvpvdeq

PG-CEPRRIEQLLFTAWPETGVPADpNAFLDFHREVQQCTrpngnlTAPMVVHCSSGVGRSGCFVAFDrLAQSAARQLTPLSVKATILSLRHERMLMVQT
|   .  |.. . .  ||..||| . .      | . |          | |||||.|..| .. || . |.   ...   . ..  .  |...|.  .||
panlkelrvslikwpnwpdrgvpde.kchtvpqrllaqvr......hgpcvvhcsagkdrlyvvvalk.lkidkldrglkvdaeevktellksraiciqt

VLQYEFVYKAVLRYLD
 ||| .. .  . .  
elqyliidrvriifar
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 694-824 3.4e-21 70.4 In-house 48-169 (350) alignment 
Range on Protein: 694-824
Range on HMM: 48-169/350.0
THKHRYSNIFAYDHTRVRVTpddAALRSDpapNGDLTTDEGLDVINTDYIDAN-FIAGVSGKAEYIVTEAPIPATMNIFWRMVFEQGVSAIVVLTRELEA
  | ||.||. |.|.||..     .|.|    ..   . .. | || .|.  . |   .  .  || | ||.| |.. |...... .|  |. || . | 
faknrYknilPYehsrvkLk...kslkss...dakkhslstnDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvkvilsltsdvel

GRLRCHRYWPEEGqstiYADITVTTTAWREQP
.. .|.|||.| .    | ||||  .. .|..
nlekcyrYWqegs....ydditvklaskweni
subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 742-941 4e-21 70.0 In-house 77-273 (301) alignment 
Range on Protein: 742-941
Range on HMM: 77-273/301.0
YIDANFIAGVSGKAEYIVTEAPIPATMNIFWRMVFEQGVSAIVVLTRELEAGRLRCHRYWPEEGQSTIYA---DITVTTTAWREQPRSARRTLRLERPG-
 | ||.|        .|.| .|...|.. || |.    |  ||.|....|    .|. | | . ....     .|.....    . .  .|||..|    
PihanwiptsGhphrfiatqgPlkntsedfwamlvqydvekivmlgqkvekleekceeylpvkisekldigrfkikiknkelilnkkiskrtlevedstg

-CEPRRIEQLLFTAWPETGVPADPNAFLDFHREVQQCTRpngnltaPMVVHCSSGVGRSGCFVAFDRLAQSAARQLTpLSVKATILSLRHERMLMVQTVL
  ..| .    .. |.. |||       |.   |..  .       |.|||||.|.||| .|.. . ||.    . | . .. ..  ||..|   |||. 
kfatrtvthyqysewtdrgvPkshaelfdlmelvkksek.......PivvhcsaGiGrsvafigteylareveadpt.ieltealkhlrehrwngvqtns

QYEFV
|  ..
qlywm
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 686-874 3.1e-20 67.2 In-house 26-197 (297) alignment 
Range on Protein: 686-874
Range on HMM: 26-197/297.0
VAAKRDANTHKHRYSNIFAYDHTRVRVtpddaalRSDPApngdlttdeGLDVINTDYIdaNFiAGVSGKAEYIVTEAPIPATMNIFWRMVFEQGVSAIVV
 .|||..  .| || .|.|.| |||..       .  ..         . | ||.||.   |      .  ||... |. ||.. ||..|.||.| .||.
ssakrnsslrknryrdilatddtrvkl.......lrvit.........erdyinadyv..vf.pdeeadlkyilaqGplsatvddfwtlvaeqdvrvivm

LTRELEAGRLRCHRYWPEEGQSTIYA-DITVTTT--AWREQPRSARRTLRLERPgCEPRRIEQLLFTAWPETGVPADPNAFLDFHREVQQCT
...  | || .|  |||.  |    | |. |        |  |     |.|     | | .    | .||. |||.| .    |. .|  |.
vaklqedGrdkcapywpsvvqerlkagdvvveflsstsdefdrviltelqliyr.sesrvvrhvqflswpdhGvpsdledlvrfqaqvcscc
subfamily_CG42327_pd Subfamily CG42327 714-872 5.1e-20 66.4 In-house 30-192 (319) alignment 
Range on Protein: 714-872
Range on HMM: 30-192/319.0
PDDAALRSDPAPNGDLTTDEGLDVINTDYIDANFIAGV-SGKAEYIVTEAPIPATMNIFWRMVFEQGVSAIVVLTRELEAGRLRCHRYWPEEG---QSTI
. .  ... | |.   ....  |  .. |.||... |  . .. || ....   .   |||.|.||    || ||   | |  .| .|.| .    .   
dksrvinvvPlPetrvvlqrigdddkdeyldasyvrGyddapnsyiaaqvsledsssdfwrtvweqqsrvivqltdlselGikvcaeylPtketldntsl

YADITVTTTAWREQPRSARRTLRLERP-GCEPRRIEQLLFtAWPETGVPADPNAFLDFHREVQQ
| || ||      . | |  || | |  . | | .    .  |.|..|||...|..    ||..
yGdilvtlkgrevkdryaistlllkrvdkeesrelthywy.kwleaevPaeeaaliamllevrs
subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 739-954 1.5e-19 65.1 In-house 58-275 (285) alignment 
Range on Protein: 739-954
Range on HMM: 58-275/285.0
NTDYIDANFIAgVSG--KAEYIVTEAPIPATMNIFWRMVFEQGVSAIVVLTRELEAGRLRCHRYWPEE-GQSTIYADITVTTTAWREQPRS-----ARRT
. ||| |...  . |  .. || |. |.| |.. ||.|.... .. ...|   .| |  .|  |.||. |.   .    .| |  .|.  .     |   
drdyihaswmr.mpgkdqstyittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekcalyypeklgevvkfgkyeitlteckeeaiagtilnaltv

LRLERPGCEPRRIEQLLFTAWPETGVPADPNAFLDFHREVQQCTrPNgnlTAPMVVHCSSGVGRSGCFVAFDRLAQsAARQLTPLSVKATILSLRHERML
.  |    ||  ....    ||.   | |   ...... |..   |.     |..||||.||||.  ||  |  .     .   . .   .  .|  |. 
intedasseplymnhvqvpwwpdqlapedarpmielykwvkkvn.pk...ekpicvhcsagvgrtatfvgidyati.rimenpniemldivremramrfq

MVQTVLQYEFVYKAVLRYLDLELQ
 ||. .|. |.|  .. |.  |  
avqshmqflflyvvlmeyfigegv
0048076 (Phosphotyrosine protein) phosphatases II 829-948 4.4e-19 64.0 In-house 34-142 (145) alignment 
Range on Protein: 829-948
Range on HMM: 34-142/145.0
RTLRLERPGCEPRRIeQLLFTAWPETGVPADPNAFLDFHREVQQCTRPNgnltAPMVVHCSSGVGRSGCFVAFDRLAQsaarqlTPLSVKATILSLRHER
 .|  |....|.  | |.|.. ||  ||| ... .|.| . .... . .     |..|||| ||||.|..|| . . .        .|.  ..  .|  |
lnltselellerlgi.qylylpwpDhgvpdllellleflefieealkeg....gpvlVHCsaGvgRtgtlvaaylmll......lgvsleealelvrsqr

MLMVQTVLQYEFVYKAVLRY
. .|... |..|.|...|..
pgavpnpgqlrflyefelel
subfamily_eak_pd Subfamily eak 742-951 2.9e-18 60.3 In-house 80-307 (332) alignment 
Range on Protein: 742-951
Range on HMM: 80-307/332.0
YIDANFIAGVSGKAEYIVTEAPIPATMNIFWRMVFEQGVSAIVVLTRELEAGRLRCHRYWPEEG-QSTIYADITVTTTAWREQPRSARRTLRLeRPGCEP
||.|  .       .||.| ..    . .||.||.||   ||| |  ..| .  .  .|.|... .   .  . |..  . ..     | | | . | | 
yinaslaefsevGrkyiltGiasedkvfafwqmvleqkspaivqlledvelkleksdkyfpdktreelkfGildverkefvkrniletrllel.skGnet

RRIEQLLFTAWPETGVPADpNAFLDFHREVQQC-----TRPNGNL----------TAP---MVVHCSSGVGRSGCFVAFDRLAQSAA-RQLTPLSVKATI
 |.    .  | || .|   . || ... ...        .. .|          | |    .. .. |  |.| ||  | | .    ..    ||.  |
hrvlhykvfGwtettlpky.edflalrkvmkevGvlllivmksallsstlkkyihtppsfapiiqsarGsaraGvfvvidllirlidnkkknlysvedli

LSLRHERMLMVQTVLQYEFVYKAVLRYLDL
|  .. |.  | . ||. |.|..|| ||  
lkvkskrihsvlvalqhsfiyeivldyllr
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 694-809 4.4e-18 59.7 In-house 49-161 (349) alignment 
Range on Protein: 694-809
Range on HMM: 49-161/349.0
THKHRYSNIFAYDHTRVRVTpddAALRSDPAPNGDLTTDEglDVINTDYIDANFI--AGVSGKAEYIVTEAPIPATMNIFWRMVFEQGVSAIVVLTRELE
  | ||..|. |.|.||..     .|.|  . .   .. .    .  |||.||..  . .| .  || | ||.|.|.. |....  .||  .. |. . |
faknrykdilPyehsrvklk...kslksskvikastsesd..sgklddyinanylkltrisvekkyiatqaPlPstvddfykvillngvklvlsLnddke

AGRLRCHRYWPEEGQSTI
 .  .|..|| |   | |
lslekcdiywqelsysni
0048179 (Phosphotyrosine protein) phosphatases II 827-943 9.1e-18 59.8 In-house 48-139 (144) alignment 
Range on Protein: 827-943
Range on HMM: 48-139/144.0
ArrtlrlerpgceprrIEQLLFTAWPETGVPADPNAFLDFHREVQQCTRPNgnltAPMVVHCSSGVGRSGCFVAFDRLAqsaarqLTPLSVKATILSLRH
                . |.|.. ||  ||| ... .|.| . .... ...     |..|||| ||||.|..|| ...       .  ||.. ..  .| 
e...............giqylhlpwpDhgvpdllellleflefieealeeg....gpvlVHCsaGvgRtgtlvaaylmk......klglsleealalvrs

ERMLMVQTVLQYEFVYK
 |. .|..  |..|...
rrpgavpnpgqlrfLle
subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 738-956 1.5e-17 58.7 In-house 44-262 (290) alignment 
Range on Protein: 738-956
Range on HMM: 44-262/290.0
INTDYIDANFIAGVSGkAEYIVTEAPIPAT-------MNIFWRMVFEQGVSAIVVLTRELEAGRL----RCHRYWPEE-GQSTIYADITVTTTAWREQPR
.| ||| ||..   .|  . |.|..|  ..       .. || |. .  |  .| |    |  .      | .| ||. |..  . ..||  .   ..  
fnddyiHAnrvtcpng.lrliltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCakYvpesvgeelkfkgltvkCkskekedd

SARRTLRLERPGCEPRRIEQLLFTAWPETGVPADPNAFLDFHREVQqCTrpngnlTAPMVVHCSSGVGRSGCFVAFDRLAQSAARQLTPLSVKATILSLR
  .|.| ..  . |.  ..  |.  | .. |. |.  .|.  . |. .       ..|..|||  |. || .. | .   |  | .   ..... . .||
vetRelvvkfddeeeftvtHsllkgWnklnvqedtktllsliqkvk.as......ktpvivHcvdGiSrsAalaaiilgyQkiaetsgsvkledvlkalr

HERMLMVQTVLQYEFVYKAVLryldLELQKH
..| |.... |.. ||  ...    | ... 
kqralaitsalelafvdagiv....llaiev
subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 756-953 2.3e-17 57.9 In-house 36-227 (255) alignment 
Range on Protein: 756-953
Range on HMM: 36-227/255.0
EYIVteapipaTMNIFWRMVFEQGVSAIVVLTRELEAGRLRCHRYWPEEG-QSTIYADITVTTTAwrEQPRSARRTLRLERPG---CEPRRIEQLLFTAW
 |..       |.. |....  .. . .|.|.   |.|. .|..|.| |  .  ..||..||||          |||..        . . ..   .. |
lysl.......tvdkfyqtivqtktevvvmlcdfaeegvekcssyfplekdeklkladvnvtttk..ssadvvlrtleitstlgekkkthtvkhysykGW

PETGVPADPNAFLDFHREVQQCtRpngnltaPMVVHCSSGVGRSGCFVAFDRLAQSAARQLT-----PLSVKATILSLRHERMLMVQTVLQYEFVYKAVL
.|   | ...  |   . |..  .       ..|||||.|.|||  ||  . . |   |.|       |  .  .  ||..|   ..| ||  |    ||
ieknaPelareilnilkvvrds.k.......svvvhCstGiGrsaafvlaelvyqkmirsldttetveldylslleelrskrkraihtPlqlafsilmvl

RYL--DLEL
 ..    ||
dlvfpkgel
subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 753-943 3e-17 57.5 In-house 3-198 (199) alignment 
Range on Protein: 753-943
Range on HMM: 3-198/199.0
GKAEYIVTEAPIPATMNIFWRMVFEQGVSAIVVLTRELEAGRLRCHRYWPE-EGQSTIYADITVTTTAWREQPRSARRTLRLERPGCEP---RRIEQLLF
|.  ||.|. |.  ||  ||.||.| |   ||..  .          |||  |  .. |. ..||| .   .|  .  .| |      |   | | .  |
gqrryiatqhplretmadfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqf

TAWPETGVPAD--PNAFLDFHREVQQctRPNGNLTAPMVVHCSSGVGRSGCFVAFDRLAQSAARQLTPL-SVKATILSLRHERMLMVQTVLQYEFVYK
|.| |   |       |.   ||| .  . . .  ||..|||| | | .| |||.|   .|     | .  .      ||  |  .. .. .|.|.|.
tswkekttpnvalfvgfvvasrevsk..kyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiyq
subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 753-943 5.3e-17 56.6 In-house 2-197 (198) alignment 
Range on Protein: 753-943
Range on HMM: 2-197/198.0
GKAEYIVTEAPIPATMNIFWRMVFEQGVSAIVVLTRELEAGRLRCHRYWPE-EGQSTIYADITVTTTAWREQPRSARRTLRLERPGCEP---RRIEQLLF
|.  ||.|. |.  |.  ||.||.| |   ||..  .          |||  |  .. |. ..||| .   .|  .  .| |      |   | | .  |
gqrryiatqhplretladfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqf

TAWPETGVPAD--PNAFLDFHREVQQctRPNGNLTAPMVVHCSSGVGRSGCFVAFDRLAQSAARQLTPL-SVKATILSLRHERMLMVQTVLQYEFVYK
|.| |   |       |.   ||| .  . . .  ||..|||| | | .| |||.|   .|     | .  .      ||  |  .. .. .|.|.|.
tswkekttpnvalfvgfvvasrevsk..kyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiyq
subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 741-951 5.4e-15 49.9 In-house 68-278 (312) alignment 
Range on Protein: 741-951
Range on HMM: 68-278/312.0
DYIDANFIAgVSGKAE-YIVTEAPIPATMNIFWRMVFEQGVSAIVVLTRELEAGRLRCHRYWPEEGQSTIYADITVTTT-------AWREQPRSARRTLR
 || |||.  .  | | ...|..|.  |   ||....  | ..|..|.  .| |  .| .|  .        |  | |          . . . . | |.
fyihanfvk.ictkperfvctqgplentcthfwqlalslgstsiillcgfvedgsekcakyisdivgfvdledhrvyteycteieiggkskdkithrvlk

LE-RPGCEPRRIEQLLFTAWPETGVPADPNAFLDFHREVQQCTRpngnltaPMVVHCSSGVGRSGCFVAFDRLAqSAARQLTPLSVKATILSLRHERMLM
.  .   .  ....  ...||. |.|   .. | .   |..  .       |.. |||.||||.| ..  . .  .| |.     || . . ||..|   
vvvkatgqesklnhyqwaswpdhgmpdscdtalrllsavkkdkk.......pviahcsagvgrtgtlaliesmi.aalrhprkqnvkdsfvllrkdrars

VQTVLQYEFVYKAVLRYLDL
|... || .. ..|| .|  
vrvfpqyvyalrcvleflys
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 837-949 1e-14 48.7 In-house 85-194 (440) alignment 
Range on Protein: 837-949
Range on HMM: 85-194/440.0
GCEPRRIEQLLFTAWPETGVPADPNAFLDFHREVQQCTRPNGNltAPMVVHCSSGVGRSGCFVAFDRLAQSAARQlTPLSVKATILSLRHERMLMVQTVL
| | | ..|  . .||. |||      | . ..|...    ||  .|..||||.|.||.|  .| | . . | |    . . . | |.| .|  ||||  
giesrtlkqyhyqgwpdkgvpkfagpvlkmiqdvnesqekagn..gpllvhcsagagrtgviiavdsilreakrs.dqidifsfinsmrnnrpqmvqtpe

QYEFVYKAVLRYL
|| ||..|||  |
qyafvheavlegl
subfamily_hpo-7_pd Subfamily hpo-7 766-949 1.6e-14 48.4 In-house 45-227 (263) alignment 
Range on Protein: 766-949
Range on HMM: 45-227/263.0
ATMNIFWRMVFEQGVSAIVVLTRELEAGRLRCHRYWPEEG-QSTIYADITVTTTAWREQP--RSARRTLRLERpGCEPRRIEQLLFTAWPETGVPADPna
 |.. |....  .. . .|.|.   |.|. .| .|.| |  .  ..|...|.||   ...  ..   .  |..   . . ...  .. |.|.  | ..  
qtidkfyqtivqtktevvvmLcDfneegvekcssyfPlekdekqklanvnvcttkvqsdvllktlellstlge.KkkthtvkhysykgWiekndpela..

fldfhREVQQCTRPNGNLtAPMVVHCSSGVGRSGCFVAFDRLAQSAARQLT-----PLSVKATILSLRHERMLMVQTVLQYEFVYKAVLRYL
     ||. .  . . |.  ..|||||.|.|||  |.  . . |   |.|       |     .  ||..|   ..| .|  |    || ..
.....reilnilkvarns.kslvvhcstGiGrsaafsvaElvyqkmirsldttstveldylsLleelrssrkraihtPmqLafsilmvLdfv
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 837-954 5.1e-14 46.8 In-house 211-349 (350) alignment 
Range on Protein: 837-954
Range on HMM: 211-349/350.0
GCEPRRIEQLLFTAWPETGVPADPNAFLDFHR---EV--QQCTR--PNGNLTAPMVVHCSSGVGRSGCFVAFDRLAQ--SAARQLTP------------L
 ..|  . || .  |.. ..  .|. .|       ..  . ...   . . ..|..||||.|||| | .|..| | .     ..||              
asdPyvvyqlqvknWkDlslllnPesilqalevkndliddlfaeshldnarsspilvhCsaGvGrtGtlvtlDsllsdfeilenltkesrkldvaaktrD

SVKATILSLRHERMLMVQTVLQYEFVYKAVLRYLDLELQ
 .. ... ||. |. |||.. |. |.|.|.| |  |...
lisiivnelrkqrismvqnldqfifiYeallfyfaLrkd
subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 765-954 5.6e-14 46.3 In-house 100-290 (302) alignment 
Range on Protein: 765-954
Range on HMM: 100-290/302.0
P---ATMNIFWRMVFEQGVSAIVVLTRELEAGRlRCHRYWP-EEGQSTIYADITVTTTAwREQPRSARRTLRLE--RPGCEPRRIEQL-LFTAWPETGVP
    . .. ||||||.. .  .|.| .| |  .   . ..| . |. . | .. | .    |.   ..  . .|    ||    . .. ..| |... ||
vdsedsveeFWrmvfqekivsvvilvgeeelkk.tlselfpkksgdykeygkmfvNnrk.VekaeeektryviEvlPegcsnsvlanvyvltnWkqkkvp

adpNAFLDFHREVQQCTRPNGNLTAPMVVHCSSGVGRSGCFVAFDRLAQSAARQlTPLSVKATILSLRHERMLMVQTVLQYEFVYKAVLRYLDLELQ
     . .  .....    . . ....|.    |.|| | |..     ..  ..     .| .. |.| .|  .|... || ..| |.| |.  ...
...vkyaeliktaakvfakkikadentvivSknGaGRagafltlavaveklqkg.kepnikeivksiRsqRpravdslkQyvslyialllyikkkvt
PDZ PDZ domain (Also known as DHR or GLGF) 303-381 1e-12 38.2 Pfam-A 2-80 (81) alignment 
Range on Protein: 303-381
Range on HMM: 2-80/81.0
VEIDR-QKGPMGFTVRSDDTLLaNHRNVVGTVKSGSMAESAGLQRQDVLVSINGNDVTNTSKETVRRLLQASDQIVCLVV
|.. . . |..||.. ...    ..  .|  |  |..|| .||.  |...|.|| ||.| |....  ... . . |.|..
vslekekrgglGfslkggsdkr.dkgifvsevvpggaaeadglkeGDkIlsvNgvdvenvshdeavqaikgkkgevtLti
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 881-948 2.8e-12 41.1 In-house 228-294 (297) alignment 
Range on Protein: 881-948
Range on HMM: 228-294/297.0
TAPMVVHCSSGVGRSGCFVAFDRLAQSAARQLTPlSVKATILSLRHERMLMVQTVLQYEFVYKAVLRY
 |...||||.||||||  |  | ...   ..  |  |.| .  ||..|  .|||. |.|..|.|||. 
nayllvhcsaGvGrsGvvvlsdvilaklrkkrip.dvaailsilreqrarlvqtleqfellydavlkk
subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 738-945 6.3e-12 39.7 In-house 67-275 (303) alignment 
Range on Protein: 738-945
Range on HMM: 67-275/303.0
INTDYIDANFIAGVSGKaEYIVTEAPIPATMNIFWRMVFEQGVSAIVVLTRELEAGRLRCHRYWPEEGQSTIYADITVTTTAWREQPRSARRTLRLE--R
 .. || |...   | |   |.|. |.. |   ||.|. || |  ...|  . |  .|  .  .|.. .   . . ..    ...   .   .|..    
sdssyihasyleldssk.kailtqlplshtaadfwqmiieqkvkcvlllltdseydklggdsvfprnqdflkfeersirvgefkrvelgdgwvlkvlsvs

PGCEPRRIEQLLFTAWPETGVPAD-PNAFLDFHREVQQCTRPNGNlTAPMVVHCSSGVGRSGCFVAFDRLAQSAARQLTPLSVKATILSLRHERMLMVQT
 |     .    . ||| . .|.|    |.    ..|   |   . . | |    ||.||.| |  |.    |   . . | .   .  .|  |.  || 
ngdyksflhvhhykawphnsipsdgspkfvkqiwqlqsvlrkysd.stptvymslsgcgragtfalfetahlslhseqasldlvkclenvrngrlhavqn

VLQYEFVYKAV
. |. .||  .
lsqfsvvytll
subfamily_CG42327_pd Subfamily CG42327 881-948 1.6e-11 38.4 In-house 247-314 (319) alignment 
Range on Protein: 881-948
Range on HMM: 247-314/319.0
TAPMVVHCSSGVGRSGCFVAFDRLAQSAARQLTPLSVKATILSLRHERMLMVQTVLQYEFVYKAVLRY
  |.||||| ||||.|  .| |   .|       . .  .. |.|..|   |.|. ||||.|| .  |
qGPlvvhcsdGvGrtGlviasdiairsleeskrsvdiPqlvssvrrdrasavltkeqyefiykvlsey
PDZ_2 PDZ domain 1525-1586 2.6e-10 29.7 Pfam-A 13-73 (82) alignment 
Range on Protein: 1525-1586
Range on HMM: 13-73/82.0
SGVVEIKSVVADTPAAEAGLQPGDQIVAVGDENVlGRTKQALLRTFREAPGDMLRLIVSRPG
.. | . ||  ..|||.|||.|||.|..|... |   ...   .  .  ||| ..| |.| |
trgvlvvsVkessPaakaglkpGDiilkvdgkkv.ksltdlkslllkkkpGdtvkltvlRdg
subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 763-940 3.9e-10 33.7 In-house 99-279 (302) alignment 
Range on Protein: 763-940
Range on HMM: 99-279/302.0
PIPATMNIFWRMVFEQGVSAIVVLTRELEAGRLRCHRYWPEEGQS-TIYADITVTTTAWREQPRS--ARRTLRL-----ER---PGCEPRRIEQLLFTAW
|   |.. .| .. .  |. .| |.   | .  .|  |. .. .    .   ||.|   ...      .....|     .        .. .. |.|.||
pkkstlekhwalieqynvaivvqlcsfvedeekkcaeyysdkvggelkfgrytvktvsvktdleeftdkksfklytveiknekkkkkvkktvdilafsaw

PETGVPADPNAFLDFhreVQQCTRPNGNltapMVVHCSSGVGRSGCFVAFDRLAQSAARQLTPlSVKATILSLRHERMLMVQTVLQYEF
|. | |..... ||    .. |     |    ..|||| ||||.| .||     |  ... .   .   .| .|. |   ||.  |  .
pdhGapkeaytaldi...lkfcesykkn....vlvhcsaGvGrtGtlvaikyGiqlcskkkvt.dllsivlpvrqcryGavqdeqqliy
subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 739-822 4.4e-10 33.6 In-house 121-200 (244) alignment 
Range on Protein: 739-822
Range on HMM: 121-200/244.0
NTDYIDANFIAGVSGKAEYIVTEAPIPATMNIFWRMVFEQGVSAIVVLTRELEAgrlrcHRYWPEEGQSTIY-ADITVTTTAWRE
   ||.| |.  .   ||||.|. |.  |   ||.|..|. |  .|||    |        |||.      |  ||||| |   |
gntyinasfvgclgrtaeyiltqhpladtsmdfwkmmlerhvnvlvvlgsveee.....deywpdseplewyeeditvtltdrde
PDZ PDZ domain (Also known as DHR or GLGF) 1498-1580 5.2e-10 29.5 Pfam-A 3-78 (81) alignment 
Range on Protein: 1498-1580
Range on HMM: 3-78/81.0
TLNK-TQDSLGMVLKELKTAGdnggtkrSGVVEIKSVVADtPAAEAG-LQPGDQIVAVGDENVLGRTKQALLRTFREAPGdMLRL
.|.| .. .||. ||. . ..       .  . ...||.. .||||. |..||.|..|....| . ..       ... |  ..|
slekekrgglGfslkggsdkr.......dkgifvsevvpg.gaaeadglkeGDkIlsvNgvdvenvshdeavqaikgkkg.evtL
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 880-953 1.2e-08 28.7 In-house 264-348 (349) alignment 
Range on Protein: 880-953
Range on HMM: 264-348/349.0
LTAPMVVHCSSGVGRSGCFVAFDRLAQ---SAARQLTPLS--------VKATILSLRHERMLMVQTVLQYEFVYKAVLRYLDLEL
 .....||||.| ||.| .| .| | .      ..   .         .  .. .||  |. ||| . |. ..|.|.|.|. | .
qlstllvhcsaGcGrtGvlvtldlllsileplqnesnkiklqallkDlisiivnelrkqrismvqnlaqfiaiyealLkyfalkk
subfamily_Sponge-PTP-4_pd Subfamily Sponge-PTP-4 739-820 2.7e-08 28.2 In-house 12-89 (130) alignment 
Range on Protein: 739-820
Range on HMM: 12-89/130.0
NTDYIDANFIAGVSGKAEYIVTEAPIPATMNIFWRMVFEQGVSAIVVLTRELEAgrlrcHRYWPEEGQSTIY-ADITVTTTAW
. .||.|.|.  .   |||. |..|. .|   ||.|..|. |  .|||    |        |||.      |  ||.||.|  
gntyinasfvGllgrtaeylltqhpladtsmdfwkmmleryvnvlvvlgsveee.....deywpdsePlewyeediivtltdr
PDZ_2 PDZ domain 312-384 8.5e-08 21.6 Pfam-A 3-72 (82) alignment 
Range on Protein: 312-384
Range on HMM: 3-72/82.0
MGFTVRSDDTllaNHRNVVGTVKSGSMAESAGLQRQDVLVSINGNDVtNTSKETVRRLLQ-ASDQIVCLVVKRK
.| .|. ...     . .| .||..| |. |||.  |......|..| ..... ...||.   .. | | |.|.
iGvsvsqlen...trgvlvvsVkessPaakaglkpGDiilkvdgkkv.ksltdlkslllkkkpGdtvkltvlRd
bZIP_1 bZIP transcription factor 1999-2045 1.3e-07 18.0 Pfam-A 17-63 (64) alignment 
Range on Protein: 1999-2045
Range on HMM: 17-63/64.0
AEKFAKQKEEYQRIMGQRVTTLETQNDELRTLNNQLKAQIEQLEEDV
| .. . |....    ..| .||..|..|.  ...|| ....|. .|
ArrsRqRKkaeieeLeekvkeLeaeNkaLkkeleelkkevaklksev
RBD-FIP FIP domain 2102-2140 1.3e-07 18.8 Pfam-A 1-46 (48) alignment 
Range on Protein: 2102-2140
Range on HMM: 1-46/48.0
SKAEVLDLLLDRDEETER-------LRQYVDAVTSVVVEKAPHLLE
|..|. .|||.. ||  |       |..|.| .   ..|. | .||
srdeLislllkqEeelsrkdehvkELedYiDnLLvrimEetPsiLe
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 748-833 2.9e-07 24.1 In-house 229-311 (440) alignment 
Range on Protein: 748-833
Range on HMM: 229-311/440.0
IAGVSGKAEYIVTEAPIPATMNIFWRMVFEQGVSAIVVLTReLEAgrLRCHRYWPEEGQSTIYADITVTTTAWREQPRSARRTLRL
. | | |  .| |. |. .|.  |||.| .  .|.|..| . |.     |  ||| . .|  .  .||      .  |   ||| |
fegyskknafiatqmpldstvldfwrlvhdyristiimlnq.lnd..ktcsiywpvntrsvtfgpftvghkgsenmnrvkvrtlel
subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 689-786 6.2e-07 23.3 In-house 33-116 (347) alignment 
Range on Protein: 689-786
Range on HMM: 33-116/347.0
KRDANTHKHRYSNIFAYDHTRVRVTPDDAALrsdpAPngdltTDEgldvInTDYIDANFIAGVSGKAEYIVTEAPIPATMNIFWRMVFEQGVSAIVVL
. . .  | |  .    | ||| ..|...      ..     .|.    .   ||.|  |     . |||.|. |.| |.  ||.||.   |. .| .
ewekslsknrskdvklidatrvvlspekskn....sr.....add....v.etyinashikfdnaskeyiltqyplpdtvrdfwkmvsvtkvtqvvti