Gene MbrePTP-sf1-2 in Monosiga brevicollis

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily MbrePTP-sf1
Protein sequence
ID Type Fasta BLAST phosphatome Note
MbreP033_AA protein Get Run
MbreP033_AA_31-303 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 34-306 4.3e-126 414.7 In-house 2-280 (281) alignment 
Range on Protein: 34-306
Range on HMM: 2-280/281.0
LFRHAERLSTNQNRGWIEEYSKFAA--IQGVAHASFTEENVNKNRYRNISAYDHTRVKITPNPHNGMSDYVNANYIP---GETKYIAAQGPVPESFYAFW
|..|...||.|.|.|.||||.|.||  .. .|.||...|||.||||.||.|||.||||.||| .| ..||.|||..|   ||..|||.|||||.|..|||
lrkhlkqlsqndnaGfieeyeklaaigvdntataskadenvlknrYsnivaYDatrvkvtpneenkntDYinanfvpgykgekeyiatqgPvPaslvafW

QMVWETKVDVIAMVTNEIEGGKLKCHRYWPeEQNSELKLGNLRIISGPARDTATHICKHFMLqNMDTNESREIVHLRYTAWPDHGVPESASAMLSFRKAI
|||||.||..|.|||.|||.|||||||||| ..|||||.|.... |  ....||.|...|.| .....|.||...|.||||||||||......|.|||..
qmvweqkvsaivmvtreieagklkChrYWP.ddnselkygdvtvkstaeeekatyierkfkl.eresgetreveqlaytaWPdhGvPattkellefrkev

LKLQKSDT---LLIHCSAGVGRTGTYIAIDTLVRRLEAGAPNLDPCAVVTEMRRARNFMVQTLVQYQFVFKALLEVINKYL
|||....|   |.|||||||||||||||.|.||...|| ...||..|||.|.|..||.||||.|||.||.||.|....|.|
lkltekktkaplvihCsaGvGrtGtyialDrlvkaveaeleeldvkavvaelrkernlmvqtvvqyefvykavldaldkel
subfamily_PTPRD_pd Subfamily PTPRD 32-306 2.1e-90 299.0 In-house 8-285 (564) alignment 
Range on Protein: 32-306
Range on HMM: 8-285/564.0
TALFRHAERLSTNQNRGWIEEYSKFAAIQGVA-HASFTEENVNKNRYRNISAYDHTRVKITPNPHNGMSDYVNANYIPG---ETKYIAAQGPVPESFYAF
..| .| ..| .|..    ||| |.   | .  .|.  ..| .|||| || ||||.||.... . .  |||.||..| |   . .|||.|||..|..  |
aelkehvaklkansdlkfeeeykkieegqqftweaankpaNkaKNRyanivaYdhsRVvLskvegdegsDYINAsfidgyrkrkayIAtqgPlaetiedF

WQMVWETKVDVIAMVTNEIEGGKLKCHRYWPEEqNsELKLGNLRIISGPARDTATHICKHFMLQNMDTNESREIVHLRYTAWPDHGVPESASAMLSFRKA
|.|||| .. .| |.|.  | || |||.||||. . . . |.| .      . |. ....| |.. ...||||. .  .|.|||||||||| ..|.... 
WRmvweqnsstiVmltkleEkgkvkchkYWPek.g.tetygeltVtleeeeeladyeirtfklkkkkssesreVrqFhFtsWPdhgvpesatslLdlirk

ILKLQKSDT--LLIHCSAGVGRTGTYIAIDTLVRRLEAgAPNLDPCAVVTEMRRARNFMVQTLVQYQFVFKALLEVINKYL
. .|...|.  ...|||||||||||.|.|| ...|...   ..|   .|...|. ||.||||  ||.|...|.|| .... 
vralnepdagPivVhCSaGVGRTGtfividamlerike.ektvDiyqyvkalrkqRnamVqteeQYiFiheailealacgn
subfamily_PTPRB_pd Subfamily PTPRB 31-304 2.6e-84 277.7 In-house 9-287 (293) alignment 
Range on Protein: 31-304
Range on HMM: 9-287/293.0
MTALFRHAERLSTNQNRGWIEEYSKFAAIQG--VAHASFTEENVNKNRYRNISAYDHTRVKITPNPHNGMSDYVNANYIPGE---TKYIAAQGPVPESFY
.. .  | ........ .. |||... |..     .|. ...| .||||.|| .|||.|||...  ..  |||.|||||||     ..||.|||.||.. 
lekfeehvkkmkadsdlrfseeyeelkavgkdqavkaaelavnraknrytnilpydhsrvkLaalkdesgsDYinanyipgynsprefiatqGPlpetvd

AFWQMVWETKVDVIAMVTNEIEGGKLKCHRYWPEEQNSElKLGNLRIISGPARDTATHICKHFMLQNmdTNESREIVHLRYTAWPDHGVPESASAMLSFR
 ||.||||.|. .| |.|. .|.|| ||..|||.....    |....     ...  ..........  ..|.|.. ....|.||||||||.....|.| 
dfWrmvwekkssiivmltqlvekgkvkCeeYWPadeepv.lyGdikvtlvaeeeledwvirelkiek..ekeerkvrqyhftsWpdhgvPektktlldfv

KAILKLQ----KSDTLLIHCSAGVGRTGTYIAIDTLVRRLEAgAPNLDPCAVVTEMRRARNFMVQTLVQYQFVFKALLEVINK
... . .    ..  ...|||||||||||.||.|.|....|     .| ...|.|.|. ||..|||  || |. ...|....|
rtvreaiektaskrPivvhCsaGvGRtGtfialdrllqaiee.edyvdifgivaelReeRnllvqtekqYifihqcvldllrk
0050432 (Phosphotyrosine protein) phosphatases II 34-307 1.4e-83 276.1 In-house 31-304 (308) alignment 
Range on Protein: 34-307
Range on HMM: 31-304/308.0
LFRHAERlsTNQNRGWIEEYSKFAAIQGVAH--ASFTEENVNKNRYRNISAYDHTRVKItpnphNGMSDYVNANYIPGE-----TKYIAAQGPVPESFYA
| .. |.   ... .. ||. .. ... .    ..  .||..||||..| .|||.|||.     .. |||.||.|..|       |.||.||| |.... 
llkllek..aldlglleeefeellsvkplleysvallpenkdkNrykdilpydhsRVkl.....degsdYInAsyvdgyssklprkfIatqgPlpntved

FWQMVWETKVDVIAMVTNEIEGGKLKCHRYWPEEQN-SELKLGNLRIISGPARDTATHICKHFMLQNMDTNESREIVHLRYTAWPDHGVPESASAMLSFR
||.|||| .| || |.|...| |. ||..|||.|.. . |. |....        ..... ...|.|....|||.. |. ||.|||||||.|....|.| 
FwrmvweqnvrvIvmLtklvengrekcaqYwplelgggsleygkftvtllseevlddytvrtleltnlgdgesrtvthfhytnWpdhgvPpspeilldfl

KAILKLQKSDTLLIHCSAGVGRTGTYIAIDTLVRRLEAGaPNLDPCAVVTEMRRARNFMVQTLVQYQFVFKALLEVINKYLL
... | ... . ..|||||||||||.||.|.|...||..  ..|.. .|  .|. |..||||. ||.|...|||| ....| 
elvrkslpggpivVHCsaGvGRtGtfialdllleqleke.ggvdvfeavkklReqRpgmvqtpeqylflyralleylklklt
0051299 (Phosphotyrosine protein) phosphatases II 31-302 4.3e-81 267.8 In-house 7-286 (288) alignment 
Range on Protein: 31-302
Range on HMM: 7-286/288.0
MTALFRHAERLSTNQNRGWIEEYSKFAAIQGVA--HASFTEENVNKNRYRNISAYDHTRVKITPNPHNGMSDYVNANYIPG---ETKYIAAQGPVPESFY
.. |... ..|  |.. |..||. .. ...     .|.  .||..||||..| .|||.|||... . .. |||.||.||.|   . |.||.||| |....
veellklvlkllangltglleefeellsllpdltlsaallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyidgynlkrkfIatqgPlpntve

AFWQMVWETKVDVIAMVTNEIEGGKLKCHRYWPEeqNSELKLGNLRIISGPARDTATHICKHFMLQNM----DTNESREIVHLRYTAWPDHGVPESASAM
 ||.|||| .| || |.|...| |. ||..|||.  .. |..|....        .. .. .....|.     ..|||.. |. ||.|||||||.|....
dFWrmvweqnvrvIvmltklvelgrekcaqYwpl..ggsltygditvtllseevlddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpdspell

LSFRKAILKL--QKSDTLLIHCSAGVGRTGTYIAIDTLVRRLEAGaPNLDPCAVVTEMRRARNFMVQTLVQYQFVFKALLEVI
|.| ... |   ... . ..|||||||||||.||.|.|...||..   .|.. .|  .|. |..||||. ||.||..|||| .
ldflrlvrkalasgggpvvVHCsaGvgRtgtfialdllleqleke.ggvdvleavkrlreqRpgmvqtpeqyrfvyealleyl
0046845 (Phosphotyrosine protein) phosphatases II 64-306 6.3e-81 267.2 In-house 21-278 (284) alignment 
Range on Protein: 64-306
Range on HMM: 21-278/284.0
HASFTEENVNKNRYRNISAYDHTRVKITPNPHN-GMSDYVNANYIPGE--------TKYIAAQGPVPESFYAFWQMVWETKVDVIAMVTNEIEGGKLKCH
...  .||..||||..| .|||.|||... ... . |||.||.|..|          |.||.|||.|.... ||.|||| .| || |.|...| |. ||.
svallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweqnvrvIVmltelvengrekca

RYWPEEqNSELKLGNLRIISGPARDTATHICKHFMLQNMD-TNESREIVHLRYTAWPDHGVPESASAMLSFRKAILKLQK----SDTLLIHCSAGVGRTG
.|||.| .. |..|....         .... ...|.|.. |.|||.. |. ||.|||||||.|.. .|.| ... .|..    . . ..||||||||||
qYwple.gevltygdftvtllseevkddytvrtleltnlgytgesrtvthfhytswpdhgvppspedlleflrlvrellenlpgggpivVHCsaGvgRtG

TYIAIDTLVRRLEAGAP--NLDPCAVVTEMRRARNFMVQTLVQYQFVFKALLEVINKYL
|.||.|.| ..||.. .  ..|.. .|  .|. |..||||| ||.||..|||| ....|
tfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyealleylklkl
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 32-308 2.2e-79 261.8 In-house 5-286 (318) alignment 
Range on Protein: 32-308
Range on HMM: 5-286/318.0
TALFRHAERLSTNQNRGWIEEYSKF--AAIQGVAHASFTEENVNKNRYRNISAYDHTRVKITPNPHNGMSDYVNANYIPGET---KYIAAQGPVPESFYA
 .| .| .|| .. .    ||| ..     .  .. | .. | .|||| || ||||||||...   .  |||.|||||.| .   .|||||.|.|| .  
edleshvrrlresGelllseeyerlsrseetvtslkslepvnkaknryanilaydhtrvkLqmlegeegsDyinanyidGyrrkkayiaaqaPlpetieD

FWQMVWETKVDVIAMVTNEIEGGKLKCHRYWPEEQNSelKLGNLRIISGPARDTATHICKHFMLQNMDTNESREIVHLRYTAWPDHGVPESASAMLSFRK
||.|||| .  || |.|.| | || |.|||||...    ..|.|..      ...... ..| ... ...|||..   .||.|||.|||||.. .|.. .
fWrmvWeqnsavivmltqeeergkakvhryWPskgsr..sygklvvelkeevelsdyvlrefkvtrteeeesrqvrqyhytsWpdegvpesgaslldlvr

AILKLQ---KSDTLLIHCSAGVGRTGTYIAIDTLVRRLEAGApNLDPCAVVTEMRRARNFMVQTLVQYQFVFKALLEVINKYLLR
 . | |   . .....||||||||||..||.|.|..|..| |  .|   .|...|. || ||||  ||.|....||| .. . . 
qvskaqqksgagpivvhCsaGvGrtGvfiavdillerikaea.lvDvfqtvkqlreqrnlmvqtedqyefiydvllealasgdte
0040438 (Phosphotyrosine protein) phosphatases II 65-306 9.6e-78 256.9 In-house 37-280 (317) alignment 
Range on Protein: 65-306
Range on HMM: 37-280/317.0
ASFTEENVNKNRYRNISAYDHTRVKITPNPHNGMSDYVNANYIPG---ETKYIAAQGPVPESFYAFWQMVWETKVDVIAMVTNEIEGGKLKCHRYWPEeq
 .  .|| .||||..|  |||.|||..| .    |||.||.|..|    .|.||.||| |.... ||.|||| .| || |.|.. | |. ||..|||.  
vaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyvdgpnlkrkfIatqgPlpntvedFwrmvweqgvtvivmLteleelgrekcaqYwpl..

NSELKLGNLRIISGPARDTATHICKHFMLQNMDTNESREIVHLRYTAWPDHGVPESASAMLSFRKAILKL--QKSDTLLIHCSAGVGRTGTYIAIDTLVR
...|. |....        |  .  ..........|||.. |. ||.|||||||.| . .|.| .|. .   ...  .|.|||||||||||.||......
getltygdftvtllseeelagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfleavrealedpggpvlVHCsaGvgRtGtfiaaylmle

RLEAGApNLDPCAVVTEMRRARNFMVQTLVQYQFVFKALLEVINKYL
.|| .  ..|.  .| |.|..|. .|||. ||.|. .|||| ....|
qlekeg.gvdveeavkelreqRpgavqtpeqyrflydalleylkrkl
0036941 (Phosphotyrosine protein) phosphatases II 64-307 1e-77 256.7 In-house 30-282 (297) alignment 
Range on Protein: 64-307
Range on HMM: 30-282/297.0
H--ASFTEENVNKNRYRNISAYDHTRVKItpnpHNGMSDYVNANYIPGET---KYIAAQGPVPESFYAFWQMVWETKVDVIAMVTNEIEGGKLKCHRYWP
.  ..  .||..||||..| .|||||||.    ... |||.||.|..|     |.||.||| |.... ||.|||| .| || |.|...| |. ||..|||
slsvallpenleknRykdilpydhtRVkl....ddegsdYinAsyvdgydlkrkfIatqgPlpntvedFWrmvweqnvtvIvmltelvelgrekcaqywp

EEQNSELKLGNLRIISGPARD--TATHICKHFMLQNMDTNESREIVHLRYTAWPDHGVPESASAMLSFRKAILKLQ----KSDTLLIHCSAGVGRTGTYI
.|....|. |....          .. .  .. .......|||.. |. || |||||||||.. .|.| ....| .    ..   |.||||||||.||.|
leegesltygdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfielvrkvlkllpsggpvlVHCsaGvgRsgtfi

AIDTLVRRLEA--GAPNLDPCAVVTEMRRARNFMVQTLVQYQFVFKALLEVINKYLL
|.|.....||     ...|.. .| ..|. |...|||| ||.|.  |||| ..|.|.
aadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallellkkklt
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 35-304 3.9e-77 254.1 In-house 9-281 (288) alignment 
Range on Protein: 35-304
Range on HMM: 9-281/288.0
FRHAERLSTNQNRGWIEEYSKFAAIQGV--AHASFTEENVNKNRYRNISAYDHTRVKITPNPHNGMSDYVNANYIPGE---TKYIAAQGPVPESFYAFWQ
  .. . | ... |  ||| . ||..     .|.   .| .||||||| .||..|||..  ...  .||.||.|| ||    ||||.|||....   ||.
vakvakksarnrtgfseeynsLaalektksvtagrlavnakknRyrnilpyDekrvklkkleeeagaDYinasyidgekkkkkyiatqgPladtvndfWe

MVWETKVDVIAMVTNEIEGGKLKCHRYWPEEQNSElKLGNLRIISGPARDTATHICKHFMLQnmDTNESREIVHLRYTAWPDHGVPESASAMLSFRKAIL
.|.|.|.  |.|.|. .|||| ||..|||.... . . |.. ..    ...  .. ....|.   ... .|| ...|.||||||||||.  .| ... . 
lvyenktstivmltelveggktkCeeYWPdadkpk.nyGsvtvtlveskeledfvlrkllle..kkkteleitqyqylaWpdhgvPeskapllellrqvk

KLQKSD--TLLIHCSAGVGRTGTYIAIDTLVRRLEAgAPNLDPCAVVTEMRRARNFMVQTLVQYQFVFKALLEVINK
  ...|   ...|||||||||||.||.|.|. ..|.    .| ...|...|. |...|||| ||.|....||..|..
vanqadtgpiivhCsaGvGrtgtFialdalidavee.edyiDvagtvaklRkqRallvqtlkqYefiyevllsliee
0045450 (Phosphotyrosine protein) phosphatases II 42-302 3e-76 252.4 In-house 22-304 (307) alignment 
Range on Protein: 42-302
Range on HMM: 22-304/307.0
STNQNRGWIEEYSKFAAIQGV----AHASFTEENVNKNRYRNISAYDHTRVKITPNPHN-GMSDYVNANYI-----------PGETKYIAAQGPVPESFY
  . . |. .|. |.  ..        ..  .|| .||||..| .|||||||... ... . |||.||.|.              .|.||.||| ||...
lldfltgllkefekllsvtvfllgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydlkrkfIatqgPlpetve

AFWQMVWETKVDVIAMVTNEIEGGKLKCHRYWPEEqNSELKLGNLRIISGPARDTATHICKHFMLQNM-DTNESREIVHLRYTAWPDHGVPESASAMLSF
 ||.|.|| .| || |.|...| |. ||..|||.| ..||  ||...        .  .. .. ....  |.|||.. |. ||.|||||||.| . .|.|
dFwrmlweqgvtvivmltelvelgrekcaqywPde.geeltygnftvtllseehldgytvrtlevtdldgtgesrtvthfhytgwpdhgvppsfeelldf

RKAILKLQ----KSDTLLIHCSAGVGRTGTYIAIDTLVRRLEAGAPN--LDPCAVVTEMRRARNFMVQTLVQYQFVFKALLEVI
 ....| .    |.   |.|||||||||||.||.... |.||..     .|.  .| ..|. |  .||.. ||.|. .|||| .
ieevrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyeallell
0047943 (Phosphotyrosine protein) phosphatases II 45-302 5.7e-76 250.9 In-house 10-272 (273) alignment 
Range on Protein: 45-302
Range on HMM: 10-272/273.0
QNRGWIEEYSKFAAIQGVA--HASFTEENVNKNRYRNISAYDHTRVKItpnpHNGMSDYVNANYIPG---ETKYIAAQGPVPESFYAFWQMVWETKVDVI
......||. ..  .. .    ..  .|| .||||..| .|||.|||.    ..| |||.||.|..|   . |.||.||| |.... ||.|||| .| ||
gltllleefelllslkplltysvallpenkdknrykdilpydhsrvkl....gdggsdyinAsyvdgynlkrkfiatqgPlpntvedfwrmvweqnvrvi

AMVTNEIEGGKLKCHRYWPEEQNS-ELKLGNLRIISGPARDTATHICKHFMLQNMDTNESREIVHLRYTAWPDHGVPESASAMLSFRKAILKLQK----S
 |.|...| |. ||..|||.|... .|. |....        ....  ...|.|..|.|||.. |. || |||||||.| . .|.| ... | ..    .
VmLtelvelgrekcaqYwpleggelsltygkftvtllseetkddytvrtleltnlgtgesrtvthfhytgwpdhgvppslesllefielvrkalealpsn

DTLLIHCSAGVGRTGTYIAIDTLVRRLEAGaPNLDPCAVVTEMRRARNFMVQTLVQYQFVFKALLEVI
 . ..|||||||||||.||.|.|...||..  ..|.. .|  .|. |  ||||. ||.|. .|||| .
gpvvVHCsaGvgRtgtfialdllldqleke.ggvdvleavkllrsqRpgmvqtpeqyrflyealleyl
0039614 (Phosphotyrosine protein) phosphatases II 24-305 1.4e-75 249.8 In-house 9-292 (297) alignment 
Range on Protein: 24-305
Range on HMM: 9-292/297.0
VSYLDQQMTALFRHAERLSTNQNRGWIEEYSKFAAIQGVAHASFTEENVNKNRYRNISAYDHTRVKITPNPHN-GMSDYVNANYIPGET----KYIAAQG
... . ....| ..  ..  |.. ....|. .   ..     .  .||..||||..| .|||.|||..|...    |||.||.|..|      |.||.||
lesipiplsvldlllllekansktllllefeellslkpdysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfIatqg

PVPESFYAFWQMVWETKVDVIAMVTNEIEGGKlKCHRYWPEEQNselKLGNLRIISGPARDTATHICKHFMLQNmdTNESREIVHLRYTAWPDHGVPESA
| ||... ||.|||| .| || |.|...| |. ||..|||||..   . |....        .  .  .. ..|  ..|||.. |. || |||||||.|.
PlpetvedFwrmvweqgvtvivmLtklvelgr.kcaqywpeegg...tygdftvtllkvehldgytvrtlevtn..ngesrtvthfqytgwpdhgvppsl

SAMLSFRKAILKLQ----KSDTLLIHCSAGVGRTGTYIAIDTLVRRLEAGaPNLDPCAVVTEMRRARNFMVQTLVQYQFVFKALLEVINKY
. .|.| ... . .    |.   |.|||||||||||.||.......|| .  ..|.  .| |.|..|. .|||. ||.|...|||| ....
ellleflelvrealaelpkggpvlVHCsaGvgRtGtfiaaylmleqleke.ggvdvleavkelreqRpgavqtpsqyrflydallellkrk
DSPc_SM00195 67-302 2.5e-75 248.6 In-house 22-262 (263) alignment 
Range on Protein: 67-302
Range on HMM: 22-262/263.0
FTEENVNKNRYRNISAYDHTRVKITPNPHNGMSDYVNANYIPGE---TKYIAAQGPVPESFYAFWQMVWETKVDVIAMVTNEIEGGKLKCHRYWPEEQNS
  ..|..||||.||  |||||||.......  |||.||||| |.    ||||.||| |. .  ||.||||.|| .|.|.|.| | || ||.||||||...
ekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlteeeengkekcdrywpeesgg

ELKLGNLRIISGPARDTA-THICKHFMLQNMDTNESREIVHLRYTAWPDHGVPESASAMLSFRKAILKLQK--SDTLLIHCSAGVGRTGTYIAIDTLVRR
. . |....       .    | ... |.. ...|.|.. .. |..|||||||.|.. .|.. .|. | ..  | ....|||||||||||...||.....
ketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkkskstssgpivVhCsaGvgRtgtfvtidiilsk

LEAGAPnLDPCAVVTEMRRARNFMVQTLVQYQFVFKALLEVI
||..   .| ...|.|.|  |  ||||| ||.|. .|.||.|
leeekk.vdifeivkelRkqRpgmvqtleqYlfiyeaileyi
PTPc_SM00194 67-302 2.5e-75 248.6 In-house 22-262 (263) alignment 
Range on Protein: 67-302
Range on HMM: 22-262/263.0
FTEENVNKNRYRNISAYDHTRVKITPNPHNGMSDYVNANYIPGE---TKYIAAQGPVPESFYAFWQMVWETKVDVIAMVTNEIEGGKLKCHRYWPEEQNS
  ..|..||||.||  |||||||.......  |||.||||| |.    ||||.||| |. .  ||.||||.|| .|.|.|.| | || ||.||||||...
ekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlteeeengkekcdrywpeesgg

ELKLGNLRIISGPARDTA-THICKHFMLQNMDTNESREIVHLRYTAWPDHGVPESASAMLSFRKAILKLQK--SDTLLIHCSAGVGRTGTYIAIDTLVRR
. . |....       .    | ... |.. ...|.|.. .. |..|||||||.|.. .|.. .|. | ..  | ....|||||||||||...||.....
ketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkkskstssgpivVhCsaGvgRtgtfvtidiilsk

LEAGAPnLDPCAVVTEMRRARNFMVQTLVQYQFVFKALLEVI
||..   .| ...|.|.|  |  ||||| ||.|. .|.||.|
leeekk.vdifeivkelRkqRpgmvqtleqYlfiyeaileyi
subfamily_PTPN3_pd Subfamily PTPN3 68-304 1.2e-73 242.5 In-house 38-277 (280) alignment 
Range on Protein: 68-304
Range on HMM: 38-277/280.0
TEENVNKNRYRNISAYDHTRVKITpnphNGMSDYVNANYI----PG---ETKYIAAQGPVPESFYAFWQMVWETKVDVIAMVTNEIEGGKLKCHRYWPEe
  ||..|||||.|..||.||||..    .. .||.||||.    |.    ..|||.|||....   ||||||| |. .| |.|. .| |. |||.|||| 
kpenlsknryrdilpydatrvklk....esetdyinanyvnmeipstglvnryiatqGPlaktatdfWqmvweqksslivmlttlverGrvkChqyWPe.

QNSELKLGNLRIISGPARDTATHICKHFMLQNMDTNESREIVHLRYTAWPDHGVPESASAMLSFRKAILKLQ--KSDTLLIHCSAGVGRTGTYIAIDTLV
.. ||..|....     . | ... ....|.. .|.|.|.|..|.|.||||||||.... .|.| . . ||.  |.. ...|||||.|||| .|...| .
tedeleygefsvkcekedetksyvlrelvlkdketkeerkilqlqylaWpdhgvPddsadflefvervrklrsgkeePvvvhCsaGigrtGvlilletal

RRLEAGAPnLDPCAVVTEMRRARNFMVQTLVQYQFVFKALLEVINK
  .||  | . | ..| .||  |  .|||  ||.|| .|.|.| ..
alieaaep.vypldivrtmrdqramlvqtasqykfvCeailkvyee
0043336 (Phosphotyrosine protein) phosphatases II 51-301 6.4e-73 240.9 In-house 24-276 (278) alignment 
Range on Protein: 51-301
Range on HMM: 24-276/278.0
EEYSKFAAIQ-GVAHASFTEENVNKNRYRNISAYDHTRVKITPNPHNGMSDYVNANYIPG---ETKYIAAQGPVPESFYAFWQMVWETKVDVIAMVTNEI
.|. ..  .. .    .  .||..||||..| .|||.|||... .    |||.||.|..|    .|.||.||| ||... ||.|||| .| .| |.|.. 
lefeellsfkldtysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyvdgynvprkfiatqgPlpetvedFwrmvwelgvttivmLtelv

EGGKLKCHRYWPeeqNSELKLGNLRIISGPARDTATHICKHFMLQNMDTNESREIVHLRYTAWPDHGVPESASAMLSFRKAILKLQ--KSDTLLIHCSAG
| |. ||..|||   .. |. |....        .. .  .. . |. ..|||...|. |..||||||||| | .|.| ||... .  ..  .|.|||||
elgrvkcaqYwp...ggsltygdftvtllkeehlddytvrtlevtnlgdgesrtvthyhylgwpdhgvpeslsllldflkavrealedsngpvlVHCsaG

VGRTGTYIAIDTLVRRLEAGApNLDPCAVVTEMRRARNFMVQTLVQYQFVFKALLEV
||||||.||...|...|| .  ..|.. .| |.|. |  .|||. ||.|...|||| 
vgRTGtfialyllleqlekeg.gvdleeavkelreqRpgavqtpsqyrflyealley
Y_phosphatase Protein-tyrosine phosphatase 71-300 1.2e-72 239.5 Pfam-A 1-235 (235) alignment 
Range on Protein: 71-300
Range on HMM: 1-235/235.0
NVNKNRYRNISAYDHTRVKItpNPHNGMSDYVNANYI---PGETKYIAAQGPVPESFYAFWQMVWETKVDVIAMVTNEIEGGKLKCHRYWPEEQNSELKL
| .||||..| .||.||||.  . ..| |||.||||.   . . |.||.|||.....  ||.|||. || ||.|.|.. | |. ||..|||||.. .|. 
nkkknRykdilpydktrvkl..kgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeeslty

GNLRIISG-PAR-DTATHICKHFMLQNMDTN-ESREIVHLRYTAWPDHGVPESASAMLSFRKAILKLQ--KSDTLLIHCSAGVGRTGTYIAIDTLVRRLE
|....        |..  . ... |.. ... |.||. .| ||.|||||||||....|.. ... | .  ||  ...|||||||||||..|.|.|...||
gdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleqle

AGAPnLDPCAVVTEMRRARNFMVQTLVQYQFVFKALLE
|.   .| . .| |.|. |. |||.| ||.|. ||.||
aeee.vdvlqivkelRkqRpgmvqsleqYiflykaile
Y_phosphatase Protein-tyrosine phosphatase 71-300 1.2e-72 239.5 In-house 1-235 (235) alignment 
Range on Protein: 71-300
Range on HMM: 1-235/235.0
NVNKNRYRNISAYDHTRVKItpNPHNGMSDYVNANYI---PGETKYIAAQGPVPESFYAFWQMVWETKVDVIAMVTNEIEGGKLKCHRYWPEEQNSELKL
| .||||..| .||.||||.  . ..| |||.||||.   . . |.||.|||.....  ||.|||. || ||.|.|.. | |. ||..|||||.. .|. 
nkkknRykdilpydktrvkl..kgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeeslty

GNLRIISG-PAR-DTATHICKHFMLQNMDTN-ESREIVHLRYTAWPDHGVPESASAMLSFRKAILKLQ--KSDTLLIHCSAGVGRTGTYIAIDTLVRRLE
|....        |..  . ... |.. ... |.||. .| ||.|||||||||....|.. ... | .  ||  ...|||||||||||..|.|.|...||
gdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleqle

AGAPnLDPCAVVTEMRRARNFMVQTLVQYQFVFKALLE
|.   .| . .| |.|. |. |||.| ||.|. ||.||
aeee.vdvlqivkelRkqRpgmvqsleqYiflykaile
subfamily_PTPN13_pd Subfamily PTPN13 51-304 2.9e-71 234.9 In-house 15-271 (273) alignment 
Range on Protein: 51-304
Range on HMM: 15-271/273.0
EEYSKFAAIQGVAHASFT--EENVNKNRYRNISAYDHTRVKITPNPHngmsdYVNANYIP-----GETKYIAAQGPVPESFYAFWQMVWETKVDVIAMVT
||. ..  .. . ... .  .|| .||||||.  ||.||||.  .       |.||..|       | .|||.|||.||.   ||||||| |..||||||
eefkelrelkpldtcevgkkkenkdknryrnvlPydetrvklgdegg.....yinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweqkaeviamvt

NEIEGGKLKCHRYWPEEQNSELKLGN-LRIISGPARDTATHICKHFMLQNMDTNESREIVHLRYTAWPDHGVPESASAMLSFRKAILKLQK-SDTLLIHC
.| |.||.||||||||..|..||. | |..      .  .   ...........||||..||....||||||| ||  .| | . . .||. .  ...||
lekekgkvkchrywPesknkklkvsnrlevellkvqkldgfvvralavkdsesgesrevahlnfvkwPdhgvPssaaellqfvaevrrlqtdagPivvhc

SAGVGRTGTYIAIDTLVRRLEAGApNLDPCAVVTEMRRARNFMVQTLVQYQFVFKALLEVINK
|||.||.||.|.||...  .|    ..|   .| ..|. |. .|||  || ||.||.|||...
saGiGrsGtlitidvvlglierdk.efdvkeivrklreqrqgvvqtkdqyifvykailevlks
0045098 (Phosphotyrosine protein) phosphatases II 67-303 3e-71 235.3 In-house 29-273 (278) alignment 
Range on Protein: 67-303
Range on HMM: 29-273/278.0
FTEENVNKNRYRNISAYDHTRVKitpnphngmsDYVNANYIPG-ETKYIAAQGPVPESFYAFWQMVWETKVDVIAMVTNEIEGGKLKCHRYWPEeqNSEL
  ..|..||||..| .|||.|||          ||.||.||.|  .|.||.||| |. . .||.|.|| .. || |.|...|.|. ||..||||  .. |
lylgnldknRykdilpydhsrVk..........dYINAsyidgypkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrekcaqywpe..ggsl

KLGNLRIISGPARDTATHICKHFMLQNM----DTNESREIVHLRYTAWPDHGVPESA--SAMLSFRKAILKLQ---------------KSDTLLIHCSAG
  |....       . . .  .....|      ..|||.. || |. |||||||..   . .|.. . |.. .               .. . |.|||||
tygdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsggpvlVHCsaG

VGRTGTYIAIDTLVRRLeaGaPNLDPCAVVTEMRRARNF-MVQTLVQYQFVFKALLEVIN
||||||..|.... ..|  . ...|.  .|.|.|. |.. .||.| ||.|....|||...
vgRtGtlvaaylmlell..e.ggvdlleavkelrsqRpglavqnleqyrflyefllelll
subfamily_PTPN12_pd Subfamily PTPN12 65-307 5.8e-71 233.7 In-house 34-282 (290) alignment 
Range on Protein: 65-307
Range on HMM: 34-282/290.0
ASFTEENVNKNRYRNISAYDHTRVKITPNPHNGMSDYVNANYIPG---ETKYIAAQGPVPESFYAFWQMVWETKVDVIAMVTNEIEGGKLKCHRYWPEEQ
|. .||||.||||..|  ||..||... . ..  |||.|||.| |   ...|||||||.|.    ||.|.||..| .. |. .|.| || ||.||||||.
agekeenvkknrykDilPydksrvelskieeeegsdYinanfikgvegkleyiaaqgPLpktlddfWrmiweknveivvmaCrevelgkkkCerYWpeeg

NSELKLGNLRIISGPARDTA-THICKHFMLQNMdtNESREIVHLRYTAWPDHGVPESASAMLSFRKAILKLQKSD--TLLIHCSAGVGRTGTYIAIDTLV
..||. |....     . .   .. . . ...   .|||..  ..||||||||||.||. .|.. ... .||.|.   |..||||||||||| ||||   
eeelefgefevtleeekavdddflirtLkveaq..kesrkvyqfhYtaWPDhgvPssaksllelielvrelqesedaPlvvhCsaGvGrtGtiiaidyvr

RRLEAGA--PNLDPCAVVTEMRRARNFMVQTLVQYQFVFKALLEVINKYLL
. |.|.   ..||   .|.|.|. |. .|||  ||..|.||..|...| | 
ellkaekipeeldvfdlvlelrkqraalvqtkeqyelvykavaelvqkele
subfamily_PTPN9_pd Subfamily PTPN9 42-302 1e-69 229.8 In-house 11-290 (297) alignment 
Range on Protein: 42-302
Range on HMM: 11-290/297.0
STNQNRGWIEEYSKF--AAIQGVAHASFTEENVNKNRYRNISAYDHTRVKITPNPHNGMSDYVNANYIPGET---KYIAAQGPVPESFYAFWQMVWETKV
  ...|| ..|| .    ...| ..|| .  |..|||| ..  ||.|||...  ... .|||.|||.. |      .||.|||... .  ||.|||| .|
kekgkrGlskeyaeirnepveGtflasklranleknrytdvlcydetrvvlakvdedeasdyinanfvdGykqkkafiatqGplkktvsdfWrmvWeqev

DVIAMVTNEIEGGKLKCHRYWPEEQNSELKLGNLRIISGPARDTATHICKHFMLQNMDTNESREIVHLRYTAWPDHGVPESASAMLSFRKAILKLQKS--
 || |.|  .| |.||| .|||.|..|  . |.|.. .   . .  .  . . ..|..|.|||...| ....|||.|||.||...| ..... . | .  
lvivmttrvvergrlkcgqyWpleeessaefgdlsvsnveveeeedykvrvleiknvkteesrkvthfqflsWPdyGvPssaaslldvlekvrekqalav

-------------DTLLIHCSAGVGRTGTYIAIDTLVRRLEAGApNLDPCAVVTEMRRARNFMVQTLVQYQFVFKALLEVI
               ...|||||.|||||.|..|  . |||  . ..| . .|  .|  | |..||  ||.| ..|.||  
kelgdewkghpsgPPivvhcsaGiGrtGtfitldiclsrleevg.tvdvvetvkllrtqrafsiqtpeqyefcylavleya
0040439 (Phosphotyrosine protein) phosphatases II 67-303 1e-69 230.2 In-house 7-247 (249) alignment 
Range on Protein: 67-303
Range on HMM: 7-247/249.0
FTEENVNKNRYRNISAYDHTRVKITPNPHNGMSDYVNANYIPG---ETKYIAAQGPVPESFYAFWQMVWETKVDVIAMVTNEIEGGKLKCHRYWPEeqNS
  .||..||||..| .|||.|||... |    |||.||.||.|    ...||.||| ||....||.|.|| .. || |.|.. | |. ||..|||.  ..
llpenkdknrypdilpydhsrvklsilpglflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywpl..gg

ELKLGNLRIISGPARDTATHICKHFMLQNMDTNESREIVHLRYTAWPDHGVPESASAMLSFRKAILKLQ----KSDTLLIHCSAGVGRTGTYIAIDTLVR
.|. |....        .  .. ...|.|. ..|||.. |..|| |||||||.| . .|.| .|..| .    |.  .|.|||||||||||.||......
sleygdftvtllsvevkddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaaylmle

RLEAGaPNLDPCAVVTEMRRARNFMVQTLVQYQFVFKALLEVIN
.||    ..|.  .| ..|..|. .||.. ||.|. .|||| ..
qleke.lgvdleeavkllrsqRpgavqnpeqyrflyeallelll
0042113 (Phosphotyrosine protein) phosphatases II 68-303 1.4e-69 229.6 In-house 6-244 (245) alignment 
Range on Protein: 68-303
Range on HMM: 6-244/245.0
TEENVNKNRYRNISAYDHTRVKITPNPHNGMSDYVNANYIPG---ETKYIAAQGPVPESFYAFWQMVWETKVDVIAMVTNEIEGGKLKCHRYWPEeqNSE
 .||..||||..| .|||||||..| ...  |||.||.|..|     |.||.||| ||.. .||.|.|| .. .| |.|.| | |. ||..|||.  ...
lpenkdknrysdilpydhtrvklspdggdldsdyinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywpl..ges

LKLGNLRIISGPARDTATHICKHFMLQNMDTNESREIVHLRYTAWPDHGVPESASAMLSFRKAILKLQK---SDTLLIHCSAGVGRTGTYIAIDTLVRRL
|. |....        .. .. .....|. ..||||..|..|. |||||||.. . .|.| ....| ..   . ..|.|||||||||||.||.......|
ltygdftvtllseehlddytvrtlevtnlgddesrevihyhylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylmleql

EAGaPNLDPCAVVTEMRRARNFMVQTLVQYQFVFKALLEVIN
|.   ....  .| |.|. |  .|||. ||.|. .|||| ..
eke.lgvsleeavkelrsqRpgavqtpsqyrflyeallellk
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 34-304 3e-69 228.5 In-house 10-285 (319) alignment 
Range on Protein: 34-304
Range on HMM: 10-285/319.0
LFRHAERLSTNQNRGWIEEYSKFAAIQGVA-HASFTEENVNKNRYRNISAYDHTRVKITPNPHNGMSDYVNANYIPG---ETKYIAAQGPVPESFYAFWQ
| .. ..| .. ...  .|. ..   . .  . . .||| .||||.|| |||.|||.... .    |||.||..| |   ..|.||.|.|. . .  ||.
LkerlkalastgetllekefkllkeavndtfdsaskeenkkknryqnilaydrtrvvlseldgvegsdyinasfidgyqerekfiatqaPlentiedfWr

MVWETKVDVIAMVTNEIEGGKLKCHRYWPEEQNSelKLGNLRIISGPARDTATHICKHFMLQNMDTN-ESREIVHLRYTAWPDHGVPESASAMLSFRKAI
|||| .. .. |.|.  | .|.|...|||||.    . |.| .     . ..  | ....|..  .. |.||..|  ||.||||.|||.| ..| . | |
mvWeeessivvmltklveklkvklkkywpeenfe..eyGrlivtleeeeeledyiirklklnkkssevetRevkhfqyteWpdhdvPekatslldllkri

LKLQKS---DTLLIHCSAGVGRTGTYIAIDTLVRRLEAGApNLDPCAVVTEMRRARNFMVQTLVQYQFVFKALLEVINK
 | ..      . .|||||||||||.|..|  . |..  .  ||   .| ..|  ||.|||.  ||.|...||||... 
rksrektqsgPivvhCsaGvGRtGtfivldamlervkeeg.vlDvfstvsrlRtqRnimvqrpeqYkfiyealleavea
subfamily_PTPN6_pd Subfamily PTPN6 47-304 8.2e-69 226.9 In-house 26-299 (306) alignment 
Range on Protein: 47-304
Range on HMM: 26-299/306.0
RGWIEEYSKFAAIQG----VAHASFTEENVNKNRYRNISAYDHTRVKITpNPHNGMSDYVNANYIPGE-----TKYIAAQGPVPESFYAFWQMVWETKVD
 |  ||. ..   .       . .   || .||||.||  .|||||... .|.   |||.||||| .|     ..|||.|| ...    ||.|||. .  
agfeeefeelqqeeakkllsrkegakpenkeknryknilPfDhtrvilk.epsvpgsdyinanyikkevkgsdksyiatqgclettvsdFWrmvwqensr

VIAMVTNEIEGGKLKCHRYWPEEQNSELkLGNLRIISGPARDTATHICKHFMLQN-MDTNESREIVHLRYTAWPDHGVPESASAMLSFRKAILKLQKSDT
|| |.|.|.| || || ||||.|...|   |.... .   ...|. | .......  . .|.||........|||||||.. .|.|.| . . . |.. .
vivmttkevErgkekCarYWPdeeekee.yGkisvtnvseksladYilRelsvskkkkkkeerevfqyhfksWPdhgvpkdpgavLdfledvnrkqeele

------LLIHCSAGVGRTGTYIAIDTLVRRLEAGAP--NLDPCAVVTEMRRARNFMVQTLVQYQFVFKALLEVINK
      ...|||||.|||||.| ||.|.. .|      ..|   .|  .|. |. .|||  ||.||.||. . |..
eaeagpivvhCsaGiGRtGtfiviDillkliekkgldadidiqklvksvreqrsglvqteqqykfvykaikkyiet
0037934 (Phosphotyrosine protein) phosphatases II 66-301 3.4e-67 221.8 In-house 5-241 (243) alignment 
Range on Protein: 66-301
Range on HMM: 5-241/243.0
SFTEENVNKNRYRNISAYDHTRVKItpnphNGmSDYVNANYIPGETKYIAAQGPVPESFYA----FWQMVWETKVDVIAMVTNEIEGGKLKCHRYWPeeq
.  .||..||||..| .|||.|||.     .| |||.|||.|..  ..|| ||| ||..      ||.|.|| ...|| |.|...| |..||..|||   
allpenlsknrysdilpydhsrvkl.....eg.sdyinanliyvtprliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywp...

NSElKLGNLRIISGPARDTATHICKHFMLQNMD-TNESREIVHLRYTAWPDHGVPESASAMLSFRKAILK----------LQKSDTLLIHCSAGVGRTGT
...   |....     . ..  .  ...|.| | ....|...|. |..|||||||.| . .|.| ... .          | .. ..|.|||||||||||
gev.tygdftvtllseehlddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRtGt

YIAIDTLVRRLeagapNLDPCAVVTEMRRARNF-MVQTLVQYQFVFKALLEV
.||.... ..|     ..|.  .| ..|. |.. .|||. ||.|. .|||| 
liaaylmllll.....gvdleeavkllreqRpgkavqtpsqyrflyeallel
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 33-303 4.3e-67 221.5 In-house 13-291 (298) alignment 
Range on Protein: 33-303
Range on HMM: 13-291/298.0
ALFRHAERLSTNQNRGWIEEYSKFAAIQG-----VAHASFTEENVNKNRYRNISAYDHTRVKITPNPHNGMSDYVNANYIPG---ETKYIAAQGPVPESF
|| . |.   ...  |. .|. .. ...        ... ..|| .|||| .| |.|..|| .. .  .  |||.|| .. .   .. .||.|.|..|..
alqklaavkkkkkltgyalefqrlnsvsseieeeekevarkpenkkkNRyadiialdssRvvLekedadeesdYiNAsflhaykgrnafiatqaPltetv

YAFWQMVWETKVDVIAMVTNEIEGGKLKCHRYWPEEQNSelKLGNLRIISGPARDTATHICKHFMLQNMDTNESREIVHLRYTAWPDHGVPESASAMLSF
  ||.||.| .. .| |.||  | .|.|.|.|||.|..   . |....      . |  |........ .....||...|..| |||.|||| |...| .
edFWrmvteedigtiVmltnleeldktkyhkywPdegke..tygeitvsllskeefadlivrklkvskkkeekerevrqlhftsWpdkgvpenatsvldl

RKAILKLQKSD---TLLIHCSAGVGRTGTYIAIDTLVRRLEAGApNLDPCAVVTEMRRARNFMVQTLVQYQFVFKALLEVIN
.. . . |.      ....|||||||.||.||||... |...    .|   ||  .|. |  .|||  || |...| ||...
lrkvrasqqqagnkpvivqCsaGvgRsGtfiaidsvlervkkeq.vvDvfqvvkvlRkkrpgavqteeqYvfiyeavleald
subfamily_Ptp69D_pd Subfamily Ptp69D 41-303 4.7e-67 221.3 In-house 16-287 (307) alignment 
Range on Protein: 41-303
Range on HMM: 16-287/307.0
LSTNQNRGWIEEYSKFA--AIQGVAHASFTEENVNKNRYRNISAYDHTRVKITPNPHNGMSDYVNANYIPGE---TKYIAAQGPVPESFYAFWQMVWETK
   . . | ..|| |     |.  ...|  .||  |||| .| |.|.||||... . .  |||.||..| |     |.||||.|| .    ||.|..| .
rkrdtdfglakeyekLeareidkstkvsekkenalknRyedikafDktRvkLkkingkedsdYinasfikgykekkkfiaaqdPveatigDfWRmiaeqe

VDVIAMVTNEIEGGKLKCHRYWPEEqnSELKLGNLRIISGPARDTATHICKHFMLQNMD-----TNESREIVHLRYTAWPDHGVPESASAMLSFRKAILK
| .| |..|. |  . ||..|||.|   | . |.. .     . .  .| ... . ...      ..||..|  .||.|.|  |||.| ..| . . . .
vtlivmlsnlteknrkkcakYWpie..devqygdilvklvseekhsdyiiReldvskkkeesgevedsrkvvqyhytgWkDskvPevargllklieqvre

LQK--SDTLLIHCSAGVGRTGTYIAIDTLVRRLEAGApNLDPCAVVTEMRRARNFMVQTLVQYQFVFKALLEVIN
|.|     ...||||||||.|...|.| |. .|.|   ..| ...| ..|. ||..|| | ||.|...|||. ..
lyklnrsPivvhCsaGvgrsgifvaldsllqqlkaed.kvdifetvkdLrsqRnllvqsleqYvflyralldyss
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 37-303 1.9e-66 219.3 In-house 12-284 (305) alignment 
Range on Protein: 37-303
Range on HMM: 12-284/305.0
HAERLSTNQNRGWIEEYSKFAAIQGVAHASFTEENVNKNRYRNISAYDHTRVKITPNPHNGMSDYVNANYIPG---ETKYIAAQGPVPESFYAFWQMVWE
. .  ......|. ..| ...  .   .   .|.|..|||...|  .|. |...|...... |||.||.|. |   . |||.||||...    ||....|
yikearvysdkgleaqykslyeeeesidvgkkeankaknrlkeitlldddriiltekeslddsdyinasyvdgykrkkkyivaqgPlkntvadfWrlive

TKVDVIAMVTNEIEGGKLKCHRYWPEEQNSELKLGNLRIISGPARDTATHICKHFMLQN-MDTNESREIVHLRYTAWPDHGVPESASAMLSFRKAILKLQ
.|| .| |.|. .|||| ||..||||... . ..|.. ..    . .. .| ... . .  . .||| ..... | |||||||..|...||. | . | |
ekvstivmltklveggkdkCrqYWpesktekkefgefsvelksektasdyieRklkisiededkesrtvlqyqltdWPdhGvpqfatsllslikrvqkdq

KSD---TLLIHCSAGVGRTGTYIAIDTLVRRLEAGApNLDPCAVVTEMRRARNFMVQTLVQYQFVFKALLEVIN
|.|   .||.||||||||||..||.|  . ||..    .|   |. ..|. |  ||||| ||.|.. || | |.
kkdkgvpllVhCsagvgRtGvfiavdialerlkkEe.vvdvfevlkqlRskrmkmvqtldqYvflhdaldelit
subfamily_PTPRG_pd Subfamily PTPRG 35-303 7.3e-66 217.5 In-house 7-288 (563) alignment 
Range on Protein: 35-303
Range on HMM: 7-288/563.0
FRHAERLSTNQNRGWIEEYS----KFAAIQGVAHASFTEENVNKNRYRNISAYDHTRVKITPNPHNGM-SDYVNANYIPG---ETKYIAAQGPVPESFYA
 .|   | .... |. ||.     . .. .  |..|  .|| .|||| || |||..|||..| | .    ||.||||| |   . ..||.|||... |  
akhvaslhadgdigfseefealqsetiskdldaehsqkpenkrKnRylnivaydrsRvklsplpgkkkklDYinAnyidGyqkskafiatqgplkdtfdd

FWQMVWETKVDVIAMVTNEIEGGKLKCHRYWPEeqNSELKLGNLRIISGPARDTATHICKHFMLQN-----MDT-NESREIVHLRYTAWPDHGVPESASA
||.|.|| .| .| |.||  | |. ||..|||.  .  ...|.|..       .|.   ......|      .  .. ... . .|| ||||||||..  
FWrmiWeqnvaiivmitnlvergrrkcdvYWPk..desetygalqvtlieeevlalytvrtlviknlklkkkkqcdteklvrqyhytkWPdhgvPehslp

MLSFRKA--ILKLQKSDTLLIHCSAGVGRTGTYIAIDTLVRRLEAGApNLDPCAVVTEMRRARNFMVQTLVQYQFVFKALLEVIN
 |.| |     . ..   ...|||||||||||||..|||......     .   ..  .|  |||.|||  ||.|...||||.|.
vLifvkkssaankaeaGPivvHcsaGvgrtGtyivldtllkqiqqen.avnvfgflkhiraqRnflvqteEqYiflhdalleaia
subfamily_PTPRA_pd Subfamily PTPRA 38-301 1e-65 216.8 In-house 23-294 (330) alignment 
Range on Protein: 38-301
Range on HMM: 23-294/330.0
AERLSTNQNRGWIEEYSKFAA--IQGVAHASFTEENVNKNRYRNISAYDHTRVKITPNPHNGMSDYVNANYIPGE---TKYIAAQGPVPESFYAFWQMVW
 .. |...|. . ||.  . |  ||..  ..  ||| .|||. ||  ||..|| ...   . .|||.|| .| |     |.||||||  |.   ||.|.|
irirsaddnklfreefnalPagpiqatlelaskeenkeknrvvnilPydfsrvilsvkeGveesdyinasfidGykekdkfiaaqGPkeetvedfwrmiw

ETKVDVIAMVTNEIEGGKLKCHRYWPEEqnSELKLGNLRIISGPARDTATHICKHFMLQ----NMDTNESREIVHLRYTAWPDHGVPESASAMLSFRKAI
| |   | |.|.  |  . ||..|||.|    .  ||.|.       .     ..|..|    ... ..|| .  . .|.||| |||  .  ||.. |..
eqksativmltelkerkeekcaqywPde..GlvtyGnirvevedetvlvdytvrkflvqqlpdatrekksrlvrqfhftswPdvGvPfepiGmlkllkkv

LKLQ--KSDTLLIHCSAGVGRTGTYIAIDTLVRRLEAGApNLDPCAVVTEMRRARNFMVQTLVQYQFVFKALLEV
 ||.  ..... .|||||||||||.|..|... |..|    .|   .| ..|  |  ||||. ||.|..|.||| 
kklnqqsagpivvhcsaGvGrtGtfivldavlervkaer.kvdvfefvkrlrlqrpqmvqtdeqyefiykvlley
subfamily_PTPN14_pd Subfamily PTPN14 59-304 3.2e-65 215.1 In-house 37-298 (300) alignment 
Range on Protein: 59-304
Range on HMM: 37-298/300.0
IQGVAHASFTEENVNKNRYRNISAYDHTRVKITPNPHNgMSDYVNANYIP-----GETKYIAAQGPVPESFYAFWQMVWETKVDVIAMVTNEIEGGKLKC
 ... ...  .||..|||....  |...||...|. .|  ..|.||  |       | .||.||||..     |||||||..|..|.|.|.|.|.|| |.
edallstaklpenaeknrfkdvlPyednrvelsptken.stgyinassikvsvggkersyivaqgPleltvqdfWqmvWeqgvqlivmlteeeedgkeks

HRYWPEE--QNSELKLGNLRIISGPARDTATHICKHFMLQNMDTNESREIVHLRYTAWPDHGVPESASAMLSFRKAILKLQK--SD---------TLLIH
..|.|..  ...... |. ....   .|. . | . . |. . ..| |...||.|| ||||||||  . .||. . .  ...  ..          .|.|
fkyfPkleskkktvefgkfkvttkfsedsdsvittglklkhlpskeertvwhlqytDWpdhgvPeDvkgflsyLeevqsvrrktnseveskeskPPvlvh

CSAGVGRTGTYIAIDTLVRRLEAGApNLDPCAVVTEMRRARNFMVQTLVQYQFVFKALLEVINK
|||||||||  |  | |.  || .  ..|   |.. .|. | ..|||| ||.||.|.|.. ...
CsaGvGrtGvlilsdlliatlehne.eidikkvlarLreqrmllvqtlaqYkfvYkvlikylkn
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 71-304 8.5e-62 203.6 In-house 20-266 (270) alignment 
Range on Protein: 71-304
Range on HMM: 20-266/270.0
NVNKNRYRNISAYDHTRVKITPNPHNGMSDYVNANYIPG----ETKYIAAQGPVPESFYAFWQMVWETKVDVIAMVTNEIEGGKLKCHRYWPEEQNSELK
. . |||..|    .|||.. .  .. .. |.||||..|    ..|||||.||.| .  .||.|.||.||  |.|.|.  | |. || ||||.|.....|
gkklnRyadiLPsPatRvrleeleedsataYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkgrkkCerYWpaepkekvk

L--GNLRIISGPARDTATHICKHFMLQnmDTNESREIVHLRYTAWPDHGVPESAS------AML----SFRKAILKLQKSDTLLIHCSAGVGRTGTYIAI
|  |......   . .  .| ..  |.  .. |.|..||  |..|||||||...        .|      |.   .|.|.. ||.||||||||||| ||.
ledgkikvlalseekeegyiltrlrle..ekgeerrlvHfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkaePllvHcsaGvgRtGtlial

DTLVRRLEAGApNLDPCAVVTEMRRARNFMVQTLVQYQFVFKALLEVINK
|. || ||    ..|. |...|.|. |  .||. .||.|..||..| ...
DiavrlLeetk.kvdvlaiieelRkdRmalvqhpeqyeflykavveyaer
subfamily_PTPRK_pd Subfamily PTPRK 33-301 3.3e-60 198.6 In-house 8-276 (314) alignment 
Range on Protein: 33-301
Range on HMM: 8-276/314.0
ALFRHAERLSTNQNRGWIEEYSKFAAIqgvAHASFTEENVNKNRYRNISAYDHTRVKITPNPHNGMSDYVNANYIPGET---KYIAAQGPVPESFYAFWQ
 |...   | .... |. |||  .        |.  .|| .|||. .| |||..||....   .  |||.||..| . .   ..|..|||..|  . ||.
dllqsiallkraegygfkeeyeslfeg...wdaakkdenreknrsgdilaydrsrvflitidgdpssdyinaalidsykrpaafivtqgPlqetvkdfWr

MVWETKVDVIAMVTNEIEGGKLKCHRYWPEEQNSelkLGNLRIISGPARDTATHICKHFMLQN--MDTNESREIVHLRYTAWPDHGVPESASAMLSFRKA
.|.. .   | |.|. .| |..|| .||||. .     |....    .   |  . . | ...     .| ||. ......||||.|| || ..|.. . 
lvydencasivmltelvevgrvkClkyWPedtev...ygdikvelvetellaelvvrifrveklargqeeirevrqfqflgWpdhdvPvsatgllklvrr

ILKLQKS--DTLLIHCSAGVGRTGTYIAIDTLVRRLEAGApNLDPCAVVTEMRRARNFMVQTLVQYQFVFKALLEV
. | |.     ...||||| |||||.||||...  .|     .|   .| ..|  .  ||.|  ||.|.. ..|| 
vkksqeeeaGrivvhCsaGaGrtGtfiaidivldmiereg.vvdvfnavktlrsrkvnmveteeqykfiydvilea
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 70-302 7.1e-60 197.3 In-house 8-242 (250) alignment 
Range on Protein: 70-302
Range on HMM: 8-242/250.0
ENVNKNRYRNISAYDHTRVKITPNPHNGMSDYVNANYIPG---ETKYIAAQGPVPESFYAFWQMVWETKVDVIAMVTNEIEGGKLkCHRYWPEEQNSelK
.| .|||| .| |.|..|| . ..  .  |||.|| .. |   .  .||.|||.....  ||.||.| |...| |.||  | .|  .|.||| |.    |
qnkeknryadiialdssrvvLekekgdkesdyinasflhgyderkafiatqgPlqatiedfWrmvleeksgtivmLtnLkesekt.yhqywPvekae..k

LGNLRIISGPARDTATHICKHFMLQNMDTNESREIVHLRYTAWPDHGVPESASAMLSFRKAILKLQKS---DTLLIHCSAGVGRTGTYIAIDTLVRRLEA
 |....        |  . ....| .   ...| ...| ...||| |||| | |.| ..| . . |.      ....|||||||.|..||||... ||. 
yGdvtvsllskeefadytkrklklskakkaderivrqlhfvvWPdkgvPevatavLellkkvqasqqqagnaPvivqCsaGvgrsGafiaidavlerlkk

GaPNLDPCAVVTEMRRARNFMVQTLVQYQFVFKALLEVI
    .|   |.  .|. |  .|..| || ||....|. .
e.kvvdvfkvikvlrkdrphavesleqyvfvyeiilkal
subfamily_PTPN23_pd Subfamily PTPN23 66-306 2.2e-59 195.6 In-house 38-284 (288) alignment 
Range on Protein: 66-306
Range on HMM: 38-284/288.0
SFTEENVNKNRYRNISAYDHTRVKITpnphNGMSDYVNANYI----PGETKYIAAQGPVPESFYAFWQMVWETKVDVIAMVTNEIEGGKLKCHRYWPEEQ
.  . ...|||.|.|  |||.|||.     ..  ||.|| ..    ||  ..||.|.| ...   ||.||.| |. || |.... | || |..|||||..
aiaklyseknrsrdilPyDhnRvklr....gskDDYinAsfvkdlspgcPdfiatqaPlqstlnDFWlmvyeqkssviVmllskeelgkpkvdrYwPedk

NSELKLGNLRIISGPARDTATHICKHFMLQNMDTNESREIVHLRYTAWPDHGVPESASAMLSFRKAILK-----LQKS-DTLLIHCSAGVGRTGTYIAID
.   | |.|..     |.| ||. ... |.  |... ....||..|.||..|||.| . .| | ... .      .||   |..||||||||||..  . 
getvkfgdlsvtlksvretethvervlkletldadavksvshlqltsWpelGvPasPetllqfldevesayeavqrksktPlvvhCsaGvgRtgvfalvy

TLVRRLEAGAPNLDPCAVVTEMRRARNFMVQTLVQYQFVFKALLEVINKYL
. || ||.|   ||   ||  .|. | ||||.  |..|...| || ....|
aavrelekgnglldiiqvvsrlreqRrfmvqekeqlkfsyeavleaarrvl
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 68-301 1.3e-58 193.4 In-house 46-278 (315) alignment 
Range on Protein: 68-301
Range on HMM: 46-278/315.0
TEENVNKNRYRNISAYDHTRVKITPNPHNGMSDYVNANYIPGET---KYIAAQGPVPESFYAFWQMVWETKVDVIAMVTNEIEGGKLKCHRYWPEEqnsE
  ||..|||| || |||..||..     .  |||||||.|.| .   .||||||| ..|   ||..|.| ..  | |.|| .|| | |. .|||..   .
kienkqknryiniiaydksrvqlpllendphsdyvnanfidGynkkrryiaaqgpnvasvkdfwrlvfeedigkivmltnlvegekrkaekywpdk...k

LKLGNLRIISGpARDTATHICKHFMlQNMDTNESREIVHLRYTAWPDHGVPESASAMLSFRKAILKLQKS--DTLLIHCSAGVGRTGTYIAIDTLVRRLE
.  |.. .      .  |...   .   .  .. ||.| |.||.||| |||... ... . . . . ...   ....|||||||||||.|..|... ..|
viyGkitvtrk.seevnteytvrtl.svvfgdnirevvqlhytswpdmgvpkytiplmnlirtvkqhhtnsvgaivvhcsaGvGrtGtfitldavldqae

AGApNLDPCAVVTEMRRARNFMVQTLVQYQFVFKALLEV
|    .|   ..| .|. |  |||.. ||||...|||| 
aen.aidvynfitgvrqnrikmvqvaeqyqfiydallet
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 68-302 3e-58 192.2 In-house 40-276 (515) alignment 
Range on Protein: 68-302
Range on HMM: 40-276/515.0
TEENVNKNRYRNISAYDHTRVKITPNPHNGMSDYVNANYIPGETK---YIAAQGPVPESFYAFWQMVWETKVDVIAMVTNEIEGGKLKCHRYWPEEQNSE
 | | .||||.||  || .|||.     |  |||.|| |||.      |||.||| . |   ||..|.. .|  |||||.  || | || .|||.     
eeinfkknryknilPydsvrvklevindnPhsdyfnasyipsfdndkayiasqgPnkasvddfWrlvlqenvttiamvtklkegdkikcgkyWPdkpgds

LKLGNLRIISGPArDTATHICKH--FMLQNMDtneSREIVHLRYTAWPDHGVPESASAMLSFRKAILK--LQKSDTLLIHCSAGVGRTGTYIAIDTLVRR
.|.|....      .. |   |    .|.. |   || .   ..| |||.|||. .|..| . |..     | . .|.||||||||||| .|.||  | .
vkfGsikvelvsl.eactggikrkltvlkgdd...srtvtqfhfteWPdkGvpkhtssllklikevkadhgqythpliihcsaGvGrtGvvisidsvvah

LEAGApNLDPCAVVTEMRRARNFMVQTLVQYQFVFKALLEVI
 . .   .|   .|| .|. | ..|||  || |.. |.|| .
akttr.mvdvfnfvtnirqkrpylvqtqeqyafiygavledl
subfamily_PTPRN_pd Subfamily PTPRN 48-306 3.9e-58 191.5 In-house 34-296 (297) alignment 
Range on Protein: 48-306
Range on HMM: 34-296/297.0
GWiEEYSKFAAIQGVAHASFTEENVNKNRYRNISAYDHTRVKITPNPHNGMSDYVNANYI----PGETKYIAAQGPVPESFYAFWQMVWETKVDVIAMVT
 | |   .. | . ..... .|.||.|||.... .|||.|||.. .  .  |||.||  |    | .. |||.|||....  .|||||||  | || ..|
ew.ealcayeaepstkevakaeknvkknrskavlpydhsrvklkeeasaeksdyinasaildhdprapayiatqgplastvadfwqmvweqGvvvivnlt

NEIEGGKLKCHRYWPEEQNSELKLGNLRIISGPARdTATHICKHFMLQNMDTNESREIVHLRYTAWPDHGVPESASAMLSFRKAILKLQ--KSDTLLIHC
.  | |  .|.||||.| ..  .. .....|     .  .. . | |.|..|.|.| .  . . .||..||| || ..| ||. . |    .| ....||
rleeegvkqckrywpdeGsevyhiyevhlvsehiw.cddylvrsfylknlqtsetrtvtqfhflswpeegvPasaksllefrrkvnksyrGrscpivvhc

SAGVGRTGTYIAIDTLVRRLEAGAPNLDPCAVVTEMRRARNFMVQTLVQYQFVFKALLEVINKYL
|.|.||||.||.|| .. ||  |. ..| .| .  .|  |. .|.|  |..|...|. | .|. |
sdGaGrtGvyilidlvlnrllkGvkeidiaatlehlrdqrpglvktkdqfefaltavaeevnail
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 67-300 5.7e-58 191.7 In-house 57-289 (319) alignment 
Range on Protein: 67-300
Range on HMM: 57-289/319.0
FTEENVNKNRYRNISAYDHTRVKITPNPHNGMSDYVNANYIPG---ETKYIAAQGPVPESFYAFWQMVWETKVDVIAMVTneieggKLKCHRYWPEEQNS
  ..| .|||. || |.|...||. .     .|||.|| .. |   . |||||||| ...   ||.|.|| ..  | ..|      | || .||| . . 
nldqnkdknriinilafdknvvklerliGeefsdyinasfvtGyqrkdkyiaaqGPldntladfWrmiweyncstivllt......kdkcsqywplkivi

ELKLGNLRIISgpARDTATHICKHFMLQN-MDTNESREIVHLRYTAWPDHGVPESASAMLSFRKA----ILKLQKSDTLLIHCSAGVGRTGTYIAIDTLV
. . ..... |    .|| .. ... | .    .. |.|    .  |||.|||...| .. . |       | ..   ...||||||||||.||..|.|.
keerfkvkvds..veetaeyvvrdielsedgkekdirkitqfhflGwpdvGvpdypsdlmrlvkkvrhltskenhranivvhcsaGvGrtGvyivldvll

RRLEAGApNLDPCAVVTEMRRARNFMVQTLVQYQFVFKALLE
 |..     .|   .| ..|. || .|| ||||.|.. ||||
drmkeek.qvdvynfvrdlrqqrntlvqdlvqykfiysalle
subfamily_PTPN1_pd Subfamily PTPN1 65-303 2.3e-57 188.9 In-house 26-272 (290) alignment 
Range on Protein: 65-303
Range on HMM: 26-272/290.0
ASFTEENVNKNRYRNISAYDHTRVKItpnpHNGMSDYVNANYIPGE---TKYIAAQGPVPESFYAFWQMVWETKVDVIAMVTNEIEGGKLKCHRYWPEEQ
.. ..|| |.||||..| |||.|.|.    ...  ||.||. .  |    .|| .|||.|.    ||||||| |   . |. . .| ...||..|||...
eaklpenrnlnryrdvspydhsrikl....eradndyinaslveleeakrsyiltqGPlpntvdhfWqmvWeqkskavvmlnkvvekeqikcaqywPqge

N-SELKLG--NLRIISGPARDTATHICKHFMLQNMDTNESREIVHLRYTAWPDHGVPESASAMLSFRKAI----LKLQKSDTLLIHCSAGVGRTGTYIAI
. .||.|   .|..      .. ... ... |.|. |.|.|||.|  ||.||| ||||| .|.|.|   .       ..    .||||||.||.||.. .
eekellledtklkvkliseerksyytvrllelenlktqetreilhfhyttwpdfgvpespaaflkflfkvresGslssdvGpavihcsaGiGrsGtfclv

DTLVRRLEAGAP--NLDPCAVVTEMRRARNFMVQTLVQYQFVFKALLEVIN
||.. ..|.     ..|   |. |.|. |  ..||  | .| . |.|| ..
dtclvliekkddlssvdikkvllelrkyrlGliqtadqlrfsylaileGak
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 68-300 3.4e-57 189.1 In-house 22-253 (284) alignment 
Range on Protein: 68-300
Range on HMM: 22-253/284.0
TEENVNKNRYRNISAYDHTRVKITPNPHNGMSDYVNANYIPG---ETKYIAAQGPVPESFYAFWQMVWETKVDVIAMVTneieggKLKCHRYWPEEQNSE
 ..| .|||. .| |.|...||. .   . .|||.|| .| |   . ||||.||| ...   ||.|.|| ..  | ..|      | || .||| . . .
ldqnkdknrighilafdknvvklerliGeefsdyinasfitGyqrkdkyiatqGPldntladfWrmiweyncstivllt......kdkcsqywplkivik

LKLGNLRIISgpARDTATHICKHFMLQN-MDTNESREIVHLRYTAWPDHGVPESASAMLSFRKA----ILKLQKSDTLLIHCSAGVGRTGTYIAIDTLVR
 . ..... |    ... .. ... | .    .. |.|    .  |||.|||...| .. . |       | ..  ....||||||||||.||..|.|. 
eerfkvkvds..veeseeyvvrdielsedgkekdirkirqfhflgwpdvgvpdypsdlmrlvkkvrhltskenhranivvhcsagvgrtgvyivldvlld

RLEAGApNLDPCAVVTEMRRARNFMVQTLVQYQFVFKALLE
|..     .|   .| ..|. || .|| ||||.|.. ||||
rmkeek.qvdvynfvrdlrqqrntlvqdlvqykfiysalle
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 67-303 1.6e-56 186.5 In-house 40-278 (315) alignment 
Range on Protein: 67-303
Range on HMM: 40-278/315.0
FTEENVNKNRYRNISAYDHTRVKITPNPHNGMSDYVNANYIPGETK---YIAAQGPVPESFYAFWQMVWETKVDVIAMVTNEIEGGKLKCHRYWPEEQNS
 ...| .||||.||  .|..|||.     .  |||.|| ||..  .   |||.||| . |   ||.||...||  |.|||.  || |.|| .|||...  
retinfkknryknilPldsarvkleviddsPdsdyinasyiksvdddkayiasqgPlkasvddfwrmvlqekvttivmvtkkqegdkikcrqywPdrkad

ELKLGNLRIISGPaRDTATHICKHFMlQNMDTNESREIVHLRYTAWPDHGVPESASAMLSFRKAILKL--QKSDTLLIHCSAGVGRTGTYIAIDTLVRRL
  ..|....      .. |   .  .    ...||| .   ..| |||.||.. .|..| . |..     .|  .||.||||||||||  |.||  | ..
svefGsikvells.leadtdgvarkl.vtrkseesrtvtqfqftewPdkGvdkqtssllklikevkadngkkefsllvhcsaGvGrtGvvisidevvaqi

EAGaPNLDPCAVVTEMRRARNFMVQTLVQYQFVFKALLEVIN
. .   .|   .|...|. | ..|||  .| |.. |.|| . 
krt.rsvdvfnfvknlrakrpylvqteeeyafiydavledll
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 71-303 7.9e-56 184.1 In-house 28-269 (274) alignment 
Range on Protein: 71-303
Range on HMM: 28-269/274.0
NVNKNRYRNISAYDHTRVKIT-PNPHNGMSDYVNANYIPGE----TKYIAAQGPVPESFYAFWQMVWETKVDVIAMVTNEIEGGKLKCHRYWPEEQNS--
. .||||..|   ...|| ..  ....  |.|.||||| |     . |.|.|||.|.    ||.|.....|.|| |.|.  |  . ||..|.|....   
sqtknryktilPnensrvllesessededssyinanyikGydeeskayvatqGPlpntvadfWrmiyqeevqvivmltklkeaneqkCavyfPdaedyei

ELKLGNLRIISGPARDTATHICKHFMLQNMDTneSREIVHLRYTAWPDHGVPESASAMLSFRKAILKLQKSDT-----LLIHCSAGVGRTGTYIAIDTLV
. . |.. |    . ..  .  ....|...    .|...|  ||.|||| .|..|...|.. . . . .....      ..|||||.|||| .|||.  |
serygdveikvekiverndysvrklvlkyler..ersvkhywytdWPdhksPddantlldlvleveesreeenaklapvvvhCsaGiGrtGcfiaisiav

RRLEAGApNLDPCAVVTEMRRARNFMVQTLVQYQFVFKALLEVIN
|.|..    .|   .|...|  |  ||||  ||.....|| .  .
rqlreei.vvdvlkivcnlrldrGGmvqtseqyelihralclylk
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 20-299 8.9e-55 180.5 In-house 16-274 (287) alignment 
Range on Protein: 20-299
Range on HMM: 16-274/287.0
LENVVSYLdQQMTALFRHAERLSTnqnrgwieeyskfaaiqgvahasfteenVNKNRYRNISAYDHTRVKITPNPHNGmSDYVNANYIPG---ETKYIAA
....     . .||.|. || | .                            |.|||| ..  .|.||| .. ... | |||.||||...   . ..|||
vdalkeds.esstatfkaaeelaa............................vkknryadvlPiddtrvllsaegelG.sdyinanyvasytddeafiaa

QGPVPESFYAFWQMVWETKVDVIAMVTNEIEGGKLKCHRYWPEEqNSELKLGNLRIISGPARDTAT-HICKHFMLQNMDTNESREIVHLRYTAWPDHGVP
|||.. .   ||..|.||.. .....| |.| ..|||..||||  .  ...|   ..          .  . . | ...|.|.| .  | . .|||....
qgPiaatvrdfwravletrsasvitmtreveearlkcykywPer.evPmrvGGysvvlldydikePeygvralrlidletrearvvkqldllswPdkvla

ESASAMLSFRKAI---LKLQKSD----TLLIHCSAGVGRTGTYIAIDTLVRRLEAgAPNLDPCAVVTEMRRARNFMVQTLVQYQFVFKALL
 .| ... |   .   ..|...      |..|...|.||.|...|. .||.|||    ..|. |||  .|  |. .||. ||......|| 
PtavglirfvldvkqhielardasevGPlvvhddvGiGrsGillatlvlvsrled.lGrvdvaavvirlreyraalvqavvqlrllyealv
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 70-300 6.2e-53 174.4 In-house 2-237 (237) alignment 
Range on Protein: 70-300
Range on HMM: 2-237/237.0
ENVNKNRYRNISAYDHTRVKITPNPHNgmSDYVNANYIPG----ETKYIAAQGPVPESFYAFWQMVWETKVDVIAMVTNEIEGGKLKCHRYWPEEQNSeL
||  |||| || ||||.|| .  .  .  |||.||.|. |      ||||||||.  |   ||||||. |  || |.|  ||| .||||.|||. ..   
enkiknrygnivaydhsrvvlkgagsg..sdyinatylkgfdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywpstdqp.a

KLGNLRIISGPARDTATHICKHFMLQN-MDTNESREIVHLRYTAWPDHGVPESASAMLSFRKAILK----LQKSDTLLIHCSAGVGRTGTYIAIDTLVRR
  | | .      . . .  . ..|.. .  .| | |   ..|.|||.|||. ..|.| ||| |..    ...|   .||||||||||| .. ||...|.
aygvltvslkkkeefsdytvrslllskrltlkevrlihqyqftswpdrgvpqqtaallrfrkniinrsphvsesgpwiihcsagvgrtgiflvidamlrq

LEAgAPNLDPCAVVTEMRRARNFMVQTLVQYQFVFKALLE
 .     .|    |  .   | ...||  || |.....||
ake.kkvvdiynyvysieedrpyiiqtkdqyvfihqtile
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 65-302 2e-52 173.2 In-house 43-284 (297) alignment 
Range on Protein: 65-302
Range on HMM: 43-284/297.0
ASFTEE--NVNKNRYRNISAYDHTRVKITPNPHNGMSDYVNANYIPGET-KYIAAQGPVPESFYAFWQMVWETKVDVIAMVTNEIEGGKlKCHRYWPEEQ
.  .|.  | .|.||.||  ||  |||.    ..  |||||| ...|   ..|. | | ...   ||.||.. .| .|.|.... |. | || |||... 
qtvaekkvnfeksRYkniLPydssRvkLaivnddpdsDyvnasfvkgnkhrlittqmPmkatvadfWamvldeqvstivmlnddnerdk.kcaryWsdkg

NSElkLGNLRIISGPARDTATHICKHFMLQNMDTNESREIVHLRYTAWPDHGVPE--SASAMLSFRKAILKL---QKSDTLLIHCSAGVGRTGTYIAIDT
 ..  .|.. ..     .    | ... ... ..   | .   ... |||. |..  |||..| . . . |    ...  ||.||.||||||| ...|| 
vtt..fGdvsvvllsvsereGfikrelevtkgkakarrvvkqyqfveWPdkaverkdsassllklisevrkdfsqnaegPllvhclaGvGrtgvlltids

LVRRLEAgAPNLDPCAVVTEMRRARNFMVQTLVQYQFVFKALLEVI
 | . .    ..|   .|. .|. | ..|||  ||.||..|.||..
vvaeakr.ekevdifglvkklrqerpylvqtkeqykfvyvavleal
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 48-304 3.3e-52 172.2 In-house 21-285 (290) alignment 
Range on Protein: 48-304
Range on HMM: 21-285/290.0
GWIEEYSKFAAIQ--GVAHASFTEENVNKNRYRNISAYDHTRVKITPNPHN--GMSDYVNANYIPG---ETKYIAAQGPVPESFYAFWQMVWETKVDVIA
|. ... .. . .    ..  .|..| ..||..||  ||  |. . | . .     .|.|| || |   . .|||.||||..    ||...|. || .| 
gfrnqfkmldsgesehtvtvgltssnkllnRfanivvyddnritLrpisghkDCtneyinAcyikgykekkqyiatqgpvsntlvdFWkliwqekvtiiv

MVTNEIEGGKLKCHRYWPEEqNSELkLGNLRIISGPARDTATHICKHFMLQNMDT-NESREIVHLRYTAWPDHG-VPESASAMLSFRKAILK--LQKSDT
|.||.|| || ||. |||.. ...  .|. .|     . . . | ... ..|... .......... |.|...| |.. .. .|.... . .   .    
mltniieegkvkCqqYWpds.dtka.ygefsikllneetlneyierklevknknsagakqsvtqyqitnwdstgkvtnpqtillvieemyktqrkrgnts

LLIHCSAGVGRTGTYIAIDTLVRRLEAGApNLDPCAVVTEMRRARNFMVQTLVQYQFVFKALLEVINK
...|||..|||.....|..| . . .      |  .|. ..|  .  .||| .|||..|. .|. ...
ivvHCSdtvgrsavfcaaattinkckteg.vidvfqvlksqRiqkpgsvqtvqqyqgifqivltylds
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 71-300 6e-50 164.6 In-house 7-238 (239) alignment 
Range on Protein: 71-300
Range on HMM: 7-238/239.0
NVNKNRYRNISAYDHTRVKITPNPHNGMSDYVNANYIP---GE-TKYIAAQGPVPESFYAFWQMVWETKVDVIAMVTNEIEGGKLKCHRYWPEeqnSELK
|  |||| || .|||.|| .     .  |||.||.|.    |    |||.|| |  |   ||.|.|. .  || |.|  ||| | |||.|||.   |  |
nkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpd...stsk

LGNLRIISGPARDTATHICKHFMLQNMDTNESREIVHLRYTAWPDHGVPESASAMLSFRKAILK--LQKSDTLLIHCSAGVGRTGTYIAIDTLVRRLEAg
  |||.    .   | .| . |.. ..   | | . . ..| |||.|||. |.|.| .|. | |  |  .   .|||||||||||... ||...|. .  
ycnlrvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcsagvgrtgaflvidamlrqakk.

APNLDPCAVVTEMRRARNFMVQTLVQYQFVFKALLE
   .|    |  .|  | .||||  || |.. |.||
qktvdifnyvkairedrphmvqtseqyvfihlavle
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 65-304 9e-50 164.3 In-house 41-280 (287) alignment 
Range on Protein: 65-304
Range on HMM: 41-280/287.0
ASFTEENVNKNRYRNISAYDHTRVKITpnphNGMSDYVNANYIPG---ETKYIAAQGPVPESFYAFWQMVWETKVDVIAMVTNEIEGGKLKCHRYWPEEQ
 . ...| .|||...|  .|  || .     .   ||.|| .| |   . ..|.|..|. .    ||..... .| .| |...| |  . .|..|||||.
hniasqnkdknRltqilvpdnyrvllk....gehpdyinavfidgykekkafiiaesPmfntarnfWkliddrnvtaivmlcqekendeevcyqyWpeek

NseLKLGNLRIISGPARDTATHICKHFMLQNMD-TNESREIVHLRYTAWPDHG-VPESASAMLSFRKAILKLQKS--DTLLIHCSAGVGRTGTYIAIDTL
.  . ||. .|       .|  | ... ..| . ... ....  ..|.|...| |.| .. .| . . . . .|.   ....|||..|||.....|..| 
s..vvlGeyniellneevnagyierklevknknkagdkqqvkqyqitnWdstgkvtepqtillvieemyktqrkrgntsivvhCsdtvGrsamfcaaatt

VRRLEAGApNLDPCAVVTEMRRARNFMVQTLVQYQFVFKALLEVINK
... .     .|   |. ..|  .  .|||  ||.|.....|| .. 
inkckteG.viDvfqvlksqriqkpgsvqtveqykfindivleylds
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 71-300 9.1e-50 164.0 In-house 8-239 (239) alignment 
Range on Protein: 71-300
Range on HMM: 8-239/239.0
NVNKNRYRNISAYDHTRVKITPNPHNGMSDYVNANYIP---GE-TKYIAAQGPVPESFYAFWQMVWETKVDVIAMVTNEIEGGKLKCHRYWPEeqnSELK
|  |||| || .|||.|| .     .  |||.||.|.    |    |||.|| |  |   ||.|.|. .  || |.|  ||| | |||.|||.   |  |
nkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpd...stsk

LGNLRIISGPARDTATHICKHFMLQNMDTNESREIVHLRYTAWPDHGVPESASAMLSFRKAILK--LQKSDTLLIHCSAGVGRTGTYIAIDTLVRRLEAg
  |||.    .   | .| . |.. ..   | | . . ..| |||.|||. |.|.| .|. | |  |  .   .|||||||||||... ||...|. .  
ycnlrvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcsagvgrtgaflvidamlrqakk.

APNLDPCAVVTEMRRARNFMVQTLVQYQFVFKALLE
   .|    |  .|  | .||||  || |.. |.||
qktvdifnyvkairedrphmvqtseqyvfihlavle
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 33-302 1.8e-48 160.3 In-house 9-288 (325) alignment 
Range on Protein: 33-302
Range on HMM: 9-288/325.0
ALFRHAERLSTNQNRGWIEEYSKFAAIQGVAH-ASFTEENVNKNRYRNISAYDHTRVKITPNPHNGMSDYVNANYIPGET---KYIAAQGPVPESFYAFW
 |  | |.  .... |.  |.    . .|.|. ..   ||..|||..|. |.|..|| .    ... |||.||.|.  .     ..||| | ...   .|
nlvehvekkkaqdqdgfahefgllpsddgiakkvamkpenkaknrfknvvaldksrvvletkkddpssdyinasylrddkkkdvflaaqaPltatindlW

QMVWETKVDVIaMVTNEIEGGKLKCHRYWPEEQNSELKLGNLRIISGPARDTATHICKHFMLQNMDTNESREIVHLRYTAWPDHGVPESASAMLSFRKAI
..| . .  |. .|.||...|| .|  |||.|     ..| |..    . . . .. . . .....  |.| .  ... .|.| ||..  ....|. . .
rlvldWrcsvv.vvlneldlgkdrcavywpkemgksktfGglevklrtieeisdyvhrvldvkqvkkGetrsvkqfqlqswddmGvqkrpatlisilqlv

LK--------LQKSDTLLIHCSAGVGRTGTYIAIDTLVRRLEAGApNLDPCAVVTEMRRARNFMVQTLVQYQFVFKALLEVI
 .         . |  .|.||||||||||..|.. ... ..   . ..|   .|  .|. |  ||.|  || ....|| |..
kavservtantkastpilvhcsaGvGrtGvfislysalakviees.rvdifgfvkklrkdrpsmvetvdqyiliyealveay
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 33-302 2.9e-47 156.1 In-house 6-279 (439) alignment 
Range on Protein: 33-302
Range on HMM: 6-279/439.0
ALFRHAERLSTNQNRGWIEEYSKFAAIQGV--AHASF--TEENVNKNRYRNISAYDHTRVKITPNPHNGMSDYVNANYIPG---ETKYIAAQGPVPESFY
 .  | |.|  |..  . |.. |  ...    . ||.   | .  ||||....|.||||| .   |    | |.||||| |   .  |||.|||  |.  
efqehvekldknkqeifkeifekinstspdyaciaslaaqeydqtknrykdvgafdhtrvtlqeipgvphshyinanyikGyyddklyiatqgpkkettd

AFWQMVWETKVDVIAMVTNEIEGGKlkchrYWPEEQnsELKLGNLRIISGPARDTATHICKHFMLQNM-D-TNESREIVHLRYTAWPDHGVPESASAMLS
 ||..|.| |.  | |.|| .|  |     ||| ..  |   |.. .      .   .. . | . |  | |.  | .... |.||||. ||  || .| 
dfwrlviekktvtivmltnlvesyk.....ywpsda..evcygdiavrvdrnielpnyvirgfkvfnerdttekertvlqfhyiawpdknvpaqashvld

FRKAILKLQKS---DTLLIHCSAGVGRTGTYIAIDTLVRRLEAGApNLDPCAVVTEMRRARNFMVQTLVQYQFVFKALLEVI
| .||   . .     ...||||||||||| ||.|  . .| .   ..|   .|. .|. |. |||.|.|| |...|.|| |
flrainsandkeeygpvvvhcsagvGrtGtiialdialeqlklen.kvdikgivkvlrkqrkqmvqalcqyvfiynavledi
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 56-302 3.5e-46 152.6 In-house 25-277 (307) alignment 
Range on Protein: 56-302
Range on HMM: 25-277/307.0
FAA--IQGVAHASFTeENVNKNRYRNISAYDHTRVKITPNphNGMSDYVNANYIPGET---KYIAAQGPVPESFYAFWQMVWETKVDVIAMVTNEIEGGK
.|    .||.  .|.  | .||||... . |..|. .. .     |||. |||.   .   |.|.||||  .. | || |. . ||. . |. . || .|
lakktpegvtveafs.antdknryqdvkcqdkgrivvkfd..glasdyihanylgiaikpkkficaqgplentqysfwamaiqekvesvimlckvielak

LKCHRYWPEEQNSELKLGNLRI-ISG---PARDTA--THICKHFMLQNMDTNESREIVHLRYTAWPDHGVPESASAMLSFRKAILKlqKSDTLLIHCSAG
.||..||| |.  .|  |.    ||     |.  |   .. .   |.   ...|| | ||... |||.|||.   . . . .|.    . . ...|||||
ikceqywpleegqklvfgeapntisvanlgakklapdedlinvttlkvdwaqksrtiqhlqwenwpdrgvpqinltainlleavry..dtnpvvvhcsaG

VGRTGTYIAIDTLVRRLEAGAPNLDPCAVVTEMRRARNFMVQTLVQYQFVFKALLEVI
|||.|| .||  .  .. ||    |   .| |.|  |.. .|| .|| .. . |||  
vGrsGtivaislvqdkmiaGinckdmkklveelrsqrhyaiqteaqylylhrvlleyf
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 49-301 3.8e-46 152.1 In-house 33-282 (290) alignment 
Range on Protein: 49-301
Range on HMM: 33-282/290.0
WIEEYSKFAAIQGVAHASFTEEN-VNKNRYRNISAYDHTRVKITpnpHNGMSDYVNANYIPGE-TKYIAAQGPVPESFYAFWQMVWETKVDVIAMVTNEI
..|.   .   | .    | ..  ..||||...   | ||| .      .  ||| |||. |  . .| .||.. ..   .|.|| ..|| .| |. . |
yleklkpylpvqylerkifdkntefkknrykdvvcndktrvilk...dGydGdyvhanyvkGlkamfiltqGalkdtvidiwrmvlqekvaaivmlceli

EGGKLKCHRYWPEEQNSELKLGNLRIISGPARDTATHICKH-FMLQNMDTNESREIVHLRYTAWPDHGVPESASAMLSFRKAILKLqkSDTLLIHCSAGV
| || ||..|.||..   | .|.. ..     |  ..| |. . ....|.  .  . ||.  .|||. |. |. |.|   ... |.  |  . .|||||.
edGkakceqyypekeGevltfGeitvlcseeddkdaniikktlsvrdkdsGkehklkhlkikswpdksvalstlallrtlrilrka..sGpvvvhcsaGi

GRTGTYIAIDTLVRRLEAGApNLDPCAVVTEMRRARNFMVQTLVQYQFVFKALLEV
|||||..||.. .. |  |  .||.  .|  .|..|   ||  .||  . ..||..
GrtGtfvaievglqilldGk.eldlldlvralrnsrlnsvqvdiqylalveilldl
0051429 (Phosphotyrosine protein) phosphatases II 98-313 3.7e-45 150.0 In-house 3-236 (272) alignment 
Range on Protein: 98-313
Range on HMM: 3-236/272.0
MSDYVNANYIPGETK------YIAAQGPVPESFYAFWQMvWETKVDVIAMVTNEIEGGKLKCHRYWP----------EEQNSELKLGNLRIISGPARDTA
.|.|.||....| ..      .....|| | .   ||.. .| ....| ....| | |.|||.||||          ..   .  .|.||..      . 
lsgyiNardvggygrvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseelll

THICKHFMLQNM-DTNESREIVHLRYTAWPDHGVPESAsaMLSFRKAILKlqkSDTLLIHCSAGVGRTGTYIAIDTLVRRLEAGAPNLD-------PCAV
 .|. ...| .. ...|.||. || ||.|||||||..|  .|.. ...|.   .  .|.|||||..||||..|.. |...... .   |       . ..
dyilrellltlllsagearevmhlhytdwpdhgvpqea..llellellld...ggpvlvHCsaGkdRTGtvvallllllgvsletivddYlltnlyleea

VTEMRRARNFMVQTLVQYQFVFKALLEVINKYLLRAKKAL
| |.|..|  .|||  ||.|...||||.....| .   .|
veelraqrpgavqteeqylflyeallellrsllsvraeyl
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 66-301 3.9e-45 148.9 In-house 40-235 (392) alignment 
Range on Protein: 66-301
Range on HMM: 40-235/392.0
SFTEENVNKNRYRNISAYDHTRVKITPNPHNGMSDYVNANYIPGE---TKYIAAQGPVPESFYAFWQMVWETKVDVIAMVTNEIEGGklkchrywpeeqn
. .| |..||||.||  || .|||.        |||.|| |||.      |||.||| . |.  ||.||.. .|  |||||.  ||              
aqkeinlkknryknilpydsarvkleviddipdsdylnasyipsfdnekayiasqgpnaaslddfwrmvfqenvttiamvtklkegd.............

selklgnlriisgpardtathickhfmlqnmDTNESREIVHLRYTAWPDHGVPESASAMLSFRKAILKLQK--SDTLLIHCSAGVGRTGTYIAIDTLVRR
                                 .. | .   ..| |||..||. .|..| | | .       .  |.|||||||||||  |.||..| .
...............................kgddartvaqfhftewPdkdvpkhtssllkfikevkadfGqythpliihcsagvgrtgvvisidsvvah

LEAgAPNLDPCAVVTEMRRARNFMVQTLVQYQFVFKALLEV
 .  .  .|   .||..|| | .||||  || |.. |.|| 
akk.trmvdvfnfvtnirrkrpymvqtkeqyafiygavled
0041856 (Phosphotyrosine protein) phosphatases II 71-302 1.2e-44 147.4 In-house 1-171 (182) alignment 
Range on Protein: 71-302
Range on HMM: 1-171/182.0
NVNKNRYRNISAYDHTRvkitpnphngMSDYVNANYIPGET---KYIAAQGPVPESFYAFWQMVWETKVDVIAMVTneieggklkCHRYWPeeqnselkl
|..||||..|  |||.|           .||.|||.. |     ..||.||| ......|..|..| .. .| ..|         ...|||         
nldknrysdilpydhsr..........dldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt.........eelywp.........

gnlriisgpardtathickhfmlqnmdTNESREIVHLRYTAWPDHGVPEsASAMLSFRKAILKlqKSDTLLIHCSAGVGRTGTYIAIDTLVRRleagapN
                           ... |......|. |||||||.  . .|.| ...|.  .. . |.|||||||||||..|.. . ..      .
...........................ellerlgiqylylpwpDhgvpd.ldelldfieevle..eggpvlVHCsaGvgRtgtlvaaylmkkl......g

LDPCAVVTEMRRARNFMVQTLVQYQFVFKALLEVI
...  .| ..|..|. ||.|. ||.|.  ||||..
vsleeavklvrsrRpgmvitpnqyfflqlallell
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 51-301 8.7e-43 141.1 In-house 19-292 (301) alignment 
Range on Protein: 51-301
Range on HMM: 19-292/301.0
EEYSKFAAIQG-VAHASFTEENVNKNRYRNISAYDHTRVKITPNPHNGM--SDYVNANYIPGE---TKYIAAQGPVPESFYAFWQMVWETKVDVIAMVTN
|.|..    .   .. ...||| . ||..||. ||. |. ..|.|.  .   .|.||.|| |    .|.||||||. .    ||...|. |.  | ||||
eqykelkegedksctvglseenkalnrfknitvyddnriilkpkpnldlcqreyinasyidgysekkkfiaaqgpmkktlvdfWrliwqekpvsivmvtn

EIEGGKLKCHRYWPEEQNSELKLGNLRIISGPAR---------------DTATHICKHFMLQNMDTNESREIVHLRYTAWPDHGV-PESASAMLSFRKAI
. || | ||..|||. .... . |.. .                     |.. .   . ...   ...|.... |  | ||..|| .| .  . .  . |
lkegtkskceqywpnseaeseefgpftvtlvneqvyPdfvirqlnvkiqdgsnngyierkfkvksdksswdvlqlqvtdWpqdGvvreprtvLqviddvi

LKLQKSD--TLLIHCSAGVGRTGTYIAIDTLVRRLEAGApNLDPCAVVTEMRRARNFMVQTLVQYQFVFKALLEV
 . || .   ...|||..|.|.|.|....  .    |     |   |.  .|| .  .|.|| || ...... . 
hrqqkigggpvvVHCSdtVsrsGvYcsvsiglEQckaeg.VVdvfqvtkavrrskpgaVtTLeqytsiydvidmy
0046846 (Phosphotyrosine protein) phosphatases II 91-302 2.3e-42 140.0 In-house 4-173 (176) alignment 
Range on Protein: 91-302
Range on HMM: 4-173/176.0
TPNPHNGMSDYVNANYIPGEtKYIAAQGPVPESFYAFWQMVWETKVDVIAMVTNEIEGGKLKCHRYWPEEQNSELklgnlriisgpardtathickhfml
..  ... .||.|||.| |  ..|| |||.|.....|..|..| ..... ..|.|.| |.|||..||||... ..                         
rllgldldldyinanlilgs.rpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgi.........................

qnmdtnesreivHLRYTAWPDHGVPESaSAMLSFRKAILKLQKSD-TLLIHCSAGVGRTGTYIAIDTLVRrleagAPNLDPCAVVTEMRRARN-FMVQTL
            .  .. |||||||.. ...|.. ..| . .|.. . |.|||||.|||||..|.. | .       .|..  .. ..|. |  ..||| 
............qylhlpwpDhgvpdl.elllellefirealkeggpvlVHCsaGigRtgtlvaayllel.....ekglsveealalvreqRplgavqtp

VQYQFVFKALLEVI
 ||.|. ...|...
eQyrflyefellll
0049772 (Phosphotyrosine protein) phosphatases II 68-305 6.9e-42 139.6 In-house 43-283 (314) alignment 
Range on Protein: 68-305
Range on HMM: 43-283/314.0
TEENVNKNRYRNISAYDhTRVKITPNPHNGmSDYVNANYIPGETKYIAAQGPVPESFYAF----------WQMV--WETKVDVIAM--------------
 ..| .|||| .|  .| .||..   |..| ||| ||.|. |  |.||.||| .. .. |          |.||  .. .| .| |              
lflnrdknryldilpad.nrvilpglpvsg.sdyinasyvdgflkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivmsrdevladelsrLd

-------VTNEIEGGklkchRYWPEEQNSELKlgnlriisgpardtathickH-------FmlqnmdtneSREIVHLRYTAWPDHGVPeSASAMLSFRKA
        ..  ..|      .....   .||                            |         .|..... .. .||...| . . ...| ..
aAlgKtpllildgng.....neptaadlellk....................eelydpelf.........erlgikylripvpDgsap.lledfdeflef

ILKLQKSDTLLIHCSAGVGRTGTYIAIDTLVRRLeagapNLDPCAVVTEMRRARN-----FMVQTLVQYQFVFKALLEVINKY
|....|   .|.||.||.|||||..... |...|     ....  .. ..|..|       ....| ||.|...|||| ....
ieeadkggpvlvHCkaGkgRtgtfvvaaylmkll.....gvsleealedvrlkRpinpnpgfieqleqyefilealleylkfl
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 41-300 3e-41 136.2 In-house 3-264 (283) alignment 
Range on Protein: 41-300
Range on HMM: 3-264/283.0
LSTNQNRGWIEEYSKFAAIQGVAHASFTEENVNKNRYRNISAYDHTRVKITPNPHngmsDYVNANYIP------GETKYIAAQGPVPESFYAFWQMVWET
|..|.|.   | . ...  .  |  . ..|| .|||...| ..|  ||.. ....    ||.|| .||       . |||.||.|. .    ||.||.. 
lrvnnnklfrevlkrlsvpdldadiasadenkrknrnqeivpadqwrvelksesr....dyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfde

KVDVIAMVTNEIEGGKLKCHRYWPEEQNSElkLGNLRIISGPARDTATHICKHFMLQNM-DTNESREIVHLRYTAWPDHGVPESASAMLSFRKAILKLQK
|.  | |.|.  |. . || .|||..   .   |.. .         . | | ..|..   ....  . | ..  | . |      ... | | | . ..
kitaivmltklqedlrikCsqyWPkrGsed..yGeftvtlrkettsnsfiikelllrvnssakstlllahyqvidWleygeqaiinslvkfnkvislqte

S--DTLLIHCSAGVGRTGTYIAIDTLVRRLEAGApNLDPCAVVTEMRRARNFMVQTLVQYQFVFKALLE
|    ...|||.|.|||...||. . |  . . .  .|  |||. ||  |  .|||| ||..| .. ||
skkgPivvhCstgiGrtavfiaasasvkdaltes.vvdvfavvkimreqrmmavqtldqyklvhelvle
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 68-305 2e-39 130.0 In-house 52-293 (305) alignment 
Range on Protein: 68-305
Range on HMM: 52-293/305.0
TEENVNKNRYRNISAYDHTRVKITPNPhngMSDYVNANYIP----GETKYIAAQGPVPESFYAFWQMVWETKVDVIAMVTNEIEGGKLKCHRYWPEEQNS
.. .. ||||... . |.. ||.   .    |||. |||.      | ..|.||||. ..   || || . ||. | |. . .| ||||| .|||  |  
adiaitknryqdvpcqdqsavkldkps...psdyihanyvgcpmipekrficaqgpldqtidefwwmviqnkveqivmlcktvelgklkcaqywpaaqge

ELK--LGN-LRIISGPA---RDTATHICkhfMLQ-NMDTNESREIVHLRYTAWPDHGVPESASAMLSFRKAILKLQksDTLLIHCSAGVGRTGTYIAIDT
 |.   |  .  .||     ||.  .|    .|. ..  ...  . ||..| ||| |||    . | .  ||   .    ...|||||.||||| .||. 
klelksgivvenvsgskpmerdaeiqit...llnltysgdqkmsvrhlqwtewpdrgvppckltslellsairgsk..vpivvhcsagigrtgtivaiey

LVRRLEAGAPNLDPCAVVTEMRRARNFMVQTLVQYQFVFKALLEV-INKY
.. ..    |      .|  .|  | | .|. ||| |. . .|.  ..||
ilekiaenkpcppmpelvkalrdqrafsiqndvqylfihrvmlnyfleky
0036282 (Phosphotyrosine protein) phosphatases II 99-295 2.3e-39 130.2 In-house 2-163 (174) alignment 
Range on Protein: 99-295
Range on HMM: 2-163/174.0
SDYVNANYIPGE---TKYIAAQGPVPesfyaFWQMVWETKVDVIAMVTNEIEGGKLKCHRYWPEeqnselklgnlriisgpardtathickhfmlqnMDT
||| ||... .    ...|| ||| .     ||.|..| .. .. |...|.| |. ||..||||                                 . .
sdyinaspldlsyitprliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe.................................lre

NESREIVHLRYTAWPDHGVPESASaMLSFRKAILKLQKS---DTLLIHCSAGVGRTGTYIAIDTLVRRLEagAPNLDPCAVVTEMRRARNFMVQTLVQYQ
 ..|..... |. |||||||...  .|.| |.. . ...    ..|.||||||||||| .|.. . |.|.   .  | ...| |.|. |  ||||  ||.
dlerlgiqylylpwpDhgvpdlsi.llefvkfveealsedpggpvlVHCsaGvgRtGtlvaaylmlrgll..eslvdaldlvrelRlqrpgmvqtpsQyr

FVF
|. 
fly
0043147 (Phosphotyrosine protein) phosphatases II 97-295 7.7e-37 122.0 In-house 3-154 (172) alignment 
Range on Protein: 97-295
Range on HMM: 3-154/172.0
GMSDYVNANYIPGE---TKYIAAQGPVPESFYAFWQMVWETKVDVIAMVTNEieggklkchrywpeeqnselklgnlriisgpardtathickhfmlQNM
. |||.||.|...    ...|| ||| .. .  ||.|..| ....| ..|..                                             .. 
egsdyinasyldlyyipdrfiatqgplrntladfwrmlkelgithivnltel.............................................lyd

DTNESREIVHLRYTAWPDHGVPeSASAMLSFRKAILK---LQKSDTLLIHCSAGVGRTGTYIAIDTLVrrleagaPNLDPCAVVTEMRRARNFMVQTLVQ
 ....|..... |. ||||||| ... .|.| . | .   |... . |.||||||||||| .|.. .         .|..  .| ..|..|. .||.  |
pellerlgiqylylpwpDhgvp.llellleflefidellalspggpvlVHCsaGvgRtgtlvaaylml.......lglsleeavalvrekRpgavqnpsq

YQFVF
|.|. 
yrfly
0049260 (Phosphotyrosine protein) phosphatases II 109-295 2e-36 120.3 In-house 7-143 (152) alignment 
Range on Protein: 109-295
Range on HMM: 7-143/152.0
GETKYIAAQGPVPESFYAFWQMVWETKVDVIAMVTNEIEGGKLKCHRYWpeeqnselklgnlriisgpardtathickhfmlqnmdtnesreivHLRYTA
  ...||.||| |...  ||.|..| ....| |.|.. | |||||..|.                                             .  .. 
mpfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi.............................................qylhlp

WPDHGVPESASAMLSFRKAILK--LQKSDTLLIHCSAGVGRTGTYIAIDTLVrrleagaPNLDPCAVVTEMRRARNFMVQTLVQYQFVF
|||||||...  .| . ..| |  |.|. . |.|||||||||||..|.. .         ....  .|  .|..|. .|..  |..|..
wpDhgvpdlsqlllflllfieklaldkggpvlVHCsaGvgRtgtlvaaylml.......lgvsleeavalvrekRpgavpnpgqlrfly
0044763 (Phosphotyrosine protein) phosphatases II 83-299 3e-36 120.1 In-house 2-168 (178) alignment 
Range on Protein: 83-299
Range on HMM: 2-168/178.0
YDHTRVKITPNPHNGMSDYVNANYIPGEtKYIAAQGPvpesfYAFWQMVWETKVDVIAMVTNEIEGGKLKCHRYWPEEQNselklgnlriisgpardtat
.|.|||.... ..  .||| ||..| .   |.....|      .......| ....| ..|.|.|.|.|||..||||| .                    
ldrtrvllsnleglersdyinaseilpg.lylgslpp.....addlellkelgithivnlteelelgflkcdpywpeeag....................

hickhfmlqnmdtnesreiVHLRYTAWPDHGVPESASAMLSFRKAILKL--QKSDTLLIHCSAGVGRTGTYIAIDTLVRRleagapNLDPCAVVTEMRRA
                   .. ... .||||||.. . .| | ..| ..  .|  . |.||||||||.|| .|.. . ..      .|.. ... ..|..
...................iqylhipipDhgvpdllehflefvefieealdekggpvlVHCsaGvgRsgtlvaaylmkkl......glsleeaielvrer

RNfMVQTLVQYQFVFKALL
|. .|..  |.... .  |
Rp.ivpnpgqlrqLyefel
subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 69-301 8.3e-36 118.4 In-house 33-269 (285) alignment 
Range on Protein: 69-301
Range on HMM: 33-269/285.0
EENVNKNRYRNISAYDHTRVKItpnpHNGMSDYVNANY--IPGE--TKYIAAQGPVPESFYAFWQMVWETKVDVIAMVTNEIEGGKLKCHRYWPEEQNSE
| | . ||| .. . . ||| .    .|   ||. |..  .||.  . ||..|||.||..  ||.|... |.  . |.   .|||  ||  |.||.    
eanpdlnryadvrcieetrvvl....knhdrdyihaswmrmpgkdqstyittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekcalyypeklgev

LKLGNLRIISGPARDTA--THICKHFMLQNMDT--NESREIVHLRYTAWPDHGVPESASAMLSFRKAILKLQ-KSDTLLIHCSAGVGRTGTYIAIDTLVR
.|.|.  |    ... |    | . . . | .   .|   . |..   |||.  || |  |. . | . |.. |   . .||||||||| |.. ||    
vkfgkyeitlteckeeaiagtilnaltvintedasseplymnhvqvpwwpdqlapedarpmielykwvkkvnpkekpicvhcsagvgrtatfvgidyati

RLEAgAPNLDPCAVVTEMRRARNFMVQTLVQYQFVFKALLEV
|.    ||..   .| |||  |   ||. .|. |..  |.| 
rime.npniemldivremramrfqavqshmqflflyvvlmey
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 70-224 1.5e-35 117.5 In-house 32-189 (297) alignment 
Range on Protein: 70-224
Range on HMM: 32-189/297.0
ENVNKNRYRNISAYDHTRVKITPNPHNgmSDYVNANYI--P---GETKYIAAQGPVPESFYAFWQMVWETKVDVIAMVTNEIEGGKLKCHRYWPEEQNSE
  . |||||.| |.| ||||.   . .  .||.||.|.  |    . ||| ||||. ..   ||..|.|  | ||.||..  |.|. ||  |||. ..  
sslrknryrdilatddtrvkllrvite..rdyinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmvaklqedGrdkcapywpsvvqer

LKLGNLR--IISGPARDTATHICkhFMLQNMDTNESREIVHLRYTAWPDHGVPESASAMLSF
|| |..    .|  . .  . |     || .  .||| . | .. .|||||||     .  |
lkagdvvveflsstsdefdrvil..telqliyrsesrvvrhvqflswpdhGvpsdledlvrf
subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 71-303 4.7e-35 115.6 In-house 37-270 (281) alignment 
Range on Protein: 71-303
Range on HMM: 37-270/281.0
NVNKNRYRNISAYDHTRVKITP-NPHNGMSDYVNANYIPG---ETKYIAAQGPVPESFYAFWQMVWETKVDVIAMVTNEIEGGKLKCHRYWPEEQNSELK
| .|||| || . | .||..    | .  .||. ||||     .  || .|||  |.   ||.|.|. .   | |. . .|  . ||  |.| .    |.
nnkknrylnipcldisrvqlkvkmpnknstdyihanyirspflkrgyiltqgpkketradfwrmiwqenttaivmlcqfletnrekcaeyfprnahcclq

LGNLRIISGPARDTATHICKHfmLQNMDTNESREIVHLRYTAWPDHGVPESASAMLSFRKAILklQKSDTLLIHCSAGVGRTGTYIAIDTLVRRLEAGAP
. .| .    .    . .  .  |.     |.| | |  .  |||  ||||.  ||   . |    .|   .|||||||||.|| .|..  .. . .   
fdklsvsyedstvnkslvttr..lnlsyegetrlithwlwkewpdwqvpessevmlkilrkir..arstppvihcsagvgrsgtlmaveialqsihshft

NLDPCAVVTEMRR-ARNFMVQTLVQYQFVFKALLEVIN
  |   .|. .|   |   |||| || ...| ||..  
lpdikqivshlrvtgraasvqtlqqymliwkvlldfgv
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 70-305 5.4e-35 115.6 In-house 47-290 (305) alignment 
Range on Protein: 70-305
Range on HMM: 47-290/305.0
ENVNKNRYRNISAYDHTRVKITP-NPHngmsDYVNANYIPGE---TKYIAAQGPVPESFYAFWQMVWETKVDVIAMVTNEIEGGKLKCHRYWPEEQNSEL
.. .||||...   |. |||. .  ||    .|. |||.       ..| .| |. ..   || | .. ||. | |. | .| |  ||. |.. ... .|
qeagknrykdvgcldnnrvklegpwph....eyihanyvstptnpkrfictqaplektcadfwymclqdkveaifmlcnllekgakkcleyfaskdkdvl

KLG--NLRII----SG----PARDTATHICKHFMLQNMDTNESREIVHLRYTAWPDHGVPESASAMLSFRKAIlKLQKSdTLLIHCSAGVGRTGTYIAID
..   . .|.    |       .|..... .  .. .   ...| . |  .  ||| ||| .  |.| . .   .  |   . .|||||.||||. . ..
efeekgqkisvkfessvtlkfrkdakakvtetvlviegpgekarkvthyhwidwpdrgvpaadlailelleka.rpskg.pivvhcsagigrtgsvvmle

TLVRRLEAGAPNLDPCAVVTEMRRARNFMVQTLVQYQFVFKALLEVINKY
 .. .| ||    |   ..  .|  ||  .||  || || . .|. ..| 
yildqllagqiiedtdkilqkireqrnnsiqtdaqylfvhqvilnyfrkk
subfamily_CG7180_pd Subfamily CG7180 66-302 1.2e-34 114.4 In-house 37-290 (296) alignment 
Range on Protein: 66-302
Range on HMM: 37-290/296.0
SFTEENVNKNRYRNISAYDHTRVKITPNPHNGMSDYVNANYIPGETK---YIAAQGPVPESFYAFWQMVWETKVDVIAMVTNEIEGGKlKCHRYWPEEQn
   .|| .|||. ..  ||..|| ..    .  |||.|| |. . .|   ||  ..|. |.  .||..|.. ... . ..|.. .  | ... |||... 
glrkenreknrdvkvvPyDynRvvLekldGeeksdYinavyvdsflkkkeyivteapkketvdefWrlvydeeisavvvLtktfdfak.mypsywpnks.

sELKLGNLRIISGPARDTATHICKHFMLQNM----------DTNESREIVHLRYTAWPD-HGVPESASAMLSFRKAILKLQKSD-------TLLIHCSAG
 . . |.. .     .  |    . | |. .           . | | . ....| |.  . || |..|.. .|. . ....          .....| |
.keqygeifveiveekqyanlkirtfkltkkivalteqekqvkaetRivklfqlteWeledkvPlstnalielrrrvrlwrekvdedpeegPvvvvssdG

VGRTGTYIAIDTLVRRLEAgAPNLDPCAVVTEMRRARNFMVQTLVQYQFVFKALLEVI
..|.| |.|||  .  .|    ..|    |  .|| |. .|..  .|....  ||| .
asRsGvylaidanlelvek.eeevdvFeavktlrrsRpqLvenveeYkyiYdvlleav
subfamily_ptpA1_pd Subfamily ptpA1 69-268 3.3e-34 113.3 In-house 45-263 (418) alignment 
Range on Protein: 69-268
Range on HMM: 45-263/418.0
EENVNKNRYRNISAYDHTRVKITPNPHNGMSDYVNANYIPGE--TKYIAAQGPVPESFYAFWQMVWETKVDVIAMVTNEIEGGKLKCHRYWPEEQNSEL-
. | .|||| ||   .||||..     .  |||.||||| |    ..|..|||.|..   ||.|||| .. .| |.. | |  ..|| |||||.   |  
khntsknrytnilpvnhtrvqlkkiqdkegsdyinanyidgaypkqfictqgplpntiadfwrmvwenrcriivmlsresencrikcdrywpeqiggeqf

-KLGNLRIISGPAR----DTATHICKHFMLQNMD---TNESREIVHLRYTAWPDHGVPESASAMLSFRKAILKLQK-----SD---TLLIHCSAGVGRTG
   ||   . |       .      .  . .|.      |.|.| . .|  |||| .|. .  .  . ..| . |.     ||    ...||||||||||
siygngnevfgtysvelveviqdpereiitrnirltfegetrditqyqyegwpdhnipdhtqpfrqllhsitnrqnqiipssdrnvpiivhcsagvgrtg

TYIAIDTLVRRLEAGAPNL
|. .   ....|.    .|
tfctavimmkkldhyfkql
0051082 (Phosphotyrosine protein) phosphatases II 98-299 5.1e-33 109.1 In-house 2-150 (151) alignment 
Range on Protein: 98-299
Range on HMM: 2-150/151.0
MSDYVNANYIPGEtkYIAAQGPVPesfyAFWQMVWETKVDVIAMVTNEIEGGklKCHRYWPEEQnselklgnlriisgpardtathickhfmlqnmdtne
.||| |..|. |   ... .|| .    .|.....| ....| ....| | |  .|..|.||..                                    
lsdyinfsyvtgg..lyrsggpla....dflellkelgiktivnlrseeerg..ycpeylpelg....................................

sREIVHLRYTAWPDHGVPESASAMLSFRKAILKlQKSDTLLIHCSAGVGRTGTYIAIDTLVRRleagapnLDPCAVVTEMRRARNFMVQTLVQYQFVFKA
 .|..|. .. |||.|.|.|  |.|.| ...|. .|.  .|.|||||.||||| .|.. . ..       ... ... |.|. |  .||.  |..|...|
.ievlhipildwpdpglplsfdavleflellld.kkngpvlvHCsaGkgRTGtlvalylmllg.......vsleealeeyrlkrpgvvqpnqqflfqlfa

LL
||
ll
subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 66-294 8.4e-32 105.1 In-house 45-273 (301) alignment 
Range on Protein: 66-294
Range on HMM: 45-273/301.0
SFTEENVNKNRYRNISAYDHTRVKITpnpHNGMSDYVNANYIPGE---TKYIAAQGPVPESFYAFWQMVWETKVDVIAMVTNEIEGGKLKCHRYWPEEQN
|..  . .|.|| ..    .| |..     .|    . ||.|| .    ..||.|||.... . || |.   .|. |.|.....|  . ||. | | . .
syaylpkdkhryptvPckPstavevi...vdGkrvPihanwiptsGhphrfiatqgPlkntsedfwamlvqydvekivmlgqkvekleekceeylpvkis

SELKLGNLRIISGPARDTATHICKHFMLQNMDTN---ESREIVHLRYTAWPDHGVPESASAMLSFRKAILKLQKsdTLLIHCSAGVGRTGTYIAIDTLVR
..|..|  .|          .  ..  |.  |.    ..| ..| .|. |.|.|||.|   .  . . . | .|   ...|||||.||. ..|. . | |
ekldigrfkikiknkelilnkkiskrtlevedstgkfatrtvthyqysewtdrgvPkshaelfdlmelvkksek..PivvhcsaGiGrsvafigteylar

RLEAgAPNLDPCAVVTEMRRARNFMVQTLVQYQFV
..||  |...    . ..|  |   |||  |  ..
evea.dptieltealkhlrehrwngvqtnsqlywm
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 70-302 1.3e-31 104.7 In-house 42-271 (288) alignment 
Range on Protein: 70-302
Range on HMM: 42-271/288.0
ENVNKNRYRNISAYDHTRVKITPNPHNgmsdYVNANYIPGE---TKYIAAQGPVPESFYAFWQMVWETKVDVIAMVTNEIEGGKLKCHRYWPEEQNSELK
.|  ..||.|.   | ||||.. .|.     |..|| .. .    . | || |.      .|.|. |. |. | |... .| || |   |.| ..  . .
anptrdryenlprcditrvklsddpdf....yiaanvvssakykrrlicaqaPlngtieelWkmllesdveyivmlcellekGkeksaeyfPsklGekar

LGNLRIISGPARDTATHICKHFMLQNMDTNESRE-IVHLRYTAWPDHGVPESASAMLSFRKAILKLQKsdTLLIHCSAGVGRTGTYIAIDTLVRRLEAgA
.| |  .    |.   .. |  .|..  . | .  . .| .  |.|.||||.  . | . . . .|||   ...|.||||||||| | |   .. |    
igrlctvvkkkradidklvkvsllriskegeekvivkilhlleWdddgvPenylsplrllevlkslqk..PivvhssaGvGrtgtlililialeslrl.d

PNLDPCAVVTEMRRARNFMVQTLVQYQFVFKALLEVI
 .|    .....|  |   .||  || .|.. .|| .
dflgirsllaklreerfkaiqtemqylyvhrcvleel
PTPc_DSPc_SM00012 201-300 6.8e-30 98.7 In-house 2-105 (105) alignment 
Range on Protein: 201-300
Range on HMM: 2-105/105.0
IVHLRYTAWPDHGVPESASAMLSFRKAILKLQK----SDTLLIHCSAGVGRTGTYIAIDTLVRRLEAGAPNLDPCAVVTEMRRARNFMVQTLVQYQFVFK
. |. ||.||||||||.....|.. .|. | ..    |  ...|||||||||||..|.|.|...||..  ..| . .| |.|. |. ||||. ||.|. .
vkhyhytgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqylflyr

ALLE
||||
alle
subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 48-315 1.4e-28 94.3 In-house 28-303 (310) alignment 
Range on Protein: 48-315
Range on HMM: 28-303/310.0
GWIEEYSKFAAIQGV--AHASFTeENVNKNRYRNISAYDHTRVKITPNpHNGMSDYVNANYIPGE---TKYIAAQGPVPESFYAFWQMVWETKVDVIAMV
| . .| |. | |    .. ... ... |||| ..   | .|||.. . .    ||. |||.  .   . .| .|||.  .   ||.|... . . | ..
glvkqyrkldakqdssltyeayk.kymhknrysdvvcldtsrvklkid.ksryedyihanyvktnylrstficsqgplqhtiidfwrmifqeraesilll

TNEIEGGKLKCHRYWPEEQNSElKLGNLRIISGPARDTATHICK---HFMLQNMDTNESR------EIVHLRYTAWPDHGVPESASAMLSFRkaILKLQK
 .  | |. ||  |||    .|   | .|.           ||.    |. .|.  .|         .  ...  ||| |||.     .  |  .|   .
ckvgeegrpkcvgywpslgvte.tygcirvtnlsesseefeicnlavtfvpdnvpvdeqpanlkelrvslikwpnwpdrgvpdekchtvpqr..llaqvr

SDTLLIHCSAGVGRTGTYIAIDTLVRRLEAGApNLDPCAVVTEMRRARNFMVQTLVQYQFVFKALLEVINKYLLRAKKALAE
    ..|||||..|... .|..  . .|. |  ..|   |.||... |   .|| .|| .. .  .        .|.|.|. 
hgpcvvhcsagkdrlyvvvalklkidkldrgl.kvdaeevktellksraiciqtelqyliidrvriifargetevaekilll
0048076 (Phosphotyrosine protein) phosphatases II 155-300 2.2e-26 87.7 In-house 1-141 (145) alignment 
Range on Protein: 155-300
Range on HMM: 1-141/145.0
RYWPEEQNSELKLGNLRIISGPARDTATHICKHFMLQNMDTNESREIVHLRYTAWPDHGVPESASAMLSFRKAILKLQKSD-TLLIHCSAGVGRTGTYIA
.||| |    | ||.|   .  ..    .|   . | .. ....|..... |. |||||||.... .|.| ..| ...|..   |.|||||||||||..|
pywpseilpglylgslptaldlellkdlgittvlnltselellerlgiqylylpwpDhgvpdllellleflefieealkeggpvlVHCsaGvgRtgtlva

IDTLVRrleagaPNLDPCAVVTEMRRARNFMVQTLVQYQFVFKALLE
.. . .       ....  .. ..|..| ..|..  |..|.....||
aylmll......lgvsleealelvrsqrpgavpnpgqlrflyefele
subfamily_egg_pd Subfamily egg 65-307 3.3e-26 86.7 In-house 34-275 (307) alignment 
Range on Protein: 65-307
Range on HMM: 34-275/307.0
ASFTEENVNKNRYRNISAYDHTRVKITPNPHNGMSDYVNANYIPGE---TKYIAAQGPVPESFYAFWQMVWETKVDVIAMVTNEIEGgkLKCHRYWPEEQ
 .....| .| | . .   | .|||.  .    . |.. ||.. |.    ..| || |. ..   ||.||.. .|. | |.|   |    .|. |||  .
taasdnnlekarskrvhckdssrvklelrrGqylddfihanrvkGkpllnefilaqaplkntvddfwrmvfqeevqyivmltsrkes..erceyywpkae

NSELKL--GNLRIISGPARDTATHICKHFMLQNMDTNesREIVHLRYTAWPdhgVPESASAMLSFRKAILKLQKSDTLLIHCSAGVGRTGTYIAIDTLVR
.  |..  |.||| .    ..|  . .   |. . ..  .|  .| .  .    | .|.     .|   .  . |   ....  || ...| .||.. . 
sdslvtvpGslrienlkvdskadplfrvtklklvGgd..deerflehwqgd...vnnssdvysplrvlrklrnlskpvvvqdilGvskaatlvaieiall

RLEAGaPNL-DPC-AVVTEMRRARNFMVQTLVQYQFVFKALLEVINKYLL
 |  | |    .    |  .|. |.. |.. ..| ||.. .| ..   . 
sllrG.pitkslvlravvflrlrrrlsvesvllylfvyrlvlfffrdvig
subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 71-311 1e-25 85.1 In-house 43-285 (312) alignment 
Range on Protein: 71-311
Range on HMM: 43-285/312.0
NVNKNRYRNISAYDHTRVKITPNPhNgmsDYVNANYIPGETK---YIAAQGPVPESFYAFWQMVWETKVDVIAMVTNEIEGGKLKCHRYWPEeQNSELKL
  . ||| ||  .|  |  .. .  |    |. ||..   ||   ....|||. ..   |||..       | ...  .| |  || .|  .   . ..|
fkdlnrypniqcwdrgrftlagde.n...fyihanfvkictkperfvctqgplentcthfwqlalslgstsiillcgfvedgsekcakyisd.ivgfvdl

GNLRI---------ISGPARDTATHICKHFMLQNmdTNESREIVHLRYTAWPDHGVPESASAMLSFRKAILKLQKsdTLLIHCSAGVGRTGTYIAIDTLV
 . |.         | | ..|  ||   . ...   | .   . | ....|||||.|.|  . | .  |. | .|   .. ||||||||||| . |....
edhrvyteycteieiggkskdkithrvlkvvvka..tgqesklnhyqwaswpdhgmpdscdtalrllsavkkdkk..pviahcsagvgrtgtlaliesmi

RRLEAG-APNLDPCAVVteMRRARNFMVQTLVQYQFVFKALLEVINKYLLRAKK
  |      |.    |.  .|. |   |... || ......||..    |  ..
aalrhprkqnvkdsfvl..lrkdrarsvrvfpqyvyalrcvleflyskglykrn
subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 125-302 3.6e-24 80.2 In-house 42-221 (255) alignment 
Range on Protein: 125-302
Range on HMM: 42-221/255.0
YAFWQMVWETKVDVIAMVTNEIEGGKLKCHRYWPEEQNSELKLGNLRIISGParDTATHICKHFML-QNM-DTNESREIVHLRYTAWPDHGVPESASAML
 .|.|..  || .|..|...  | |. ||..|.| |..  ||| .. ...     .|  . .   .  .. .  . ... |  |. |...  || |  .|
dkfyqtivqtktevvvmlcdfaeegvekcssyfplekdeklkladvnvtttk..ssadvvlrtleitstlgekkkthtvkhysykGWieknaPelareil

SFRKAIlklQKSDTLLIHCSAGVGRTGTYIAIDTLV----RRLEA-GAPNLDPCAVVTEMRRARNFMVQTLVQYQFVFKALLEVI
   |..   ..| ....|||.|.||. ... .. .     | |.   . .||   ...|.|  |.  ..| .|  | .  .|...
nilkvv...rdsksvvvhCstGiGrsaafvlaelvyqkmirsldttetveldylslleelrskrkraihtPlqlafsilmvldlv
subfamily_CG42327_pd Subfamily CG42327 71-224 3e-23 77.0 In-house 28-186 (319) alignment 
Range on Protein: 71-224
Range on HMM: 28-186/319.0
NVNKNRYRNISAYDHTRVKITPNPHNGMSDYVNANYIPGE----TKYIAAQGPVPESFYAFWQMVWETKVDVIAMVTNEIEGGKLKCHRYWPEEQN--SE
  .|.|. |.    .|||     . .  . |..|.|. |     . ||||| .  .|  .||..||| .  ||  .|.  | |  .| .|.| ..   ..
skdksrvinvvPlPetrvvlqrigdddkdeyldasyvrGyddapnsyiaaqvsledsssdfwrtvweqqsrvivqltdlselGikvcaeylPtketldnt

LKLGNLRIISGPARDTATHICKHFMLQNMDTNESREIVHLRYtAWPDHGVPESASAMLSF
   |....          ..   ..|...| .||||. |  |  |.. .|| . .|... 
slyGdilvtlkgrevkdryaistlllkrvdkeesrelthywy.kwleaevPaeeaaliam
subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 109-296 4.4e-23 76.5 In-house 3-198 (199) alignment 
Range on Protein: 109-296
Range on HMM: 3-198/199.0
GETKYIAAQGPVPESFYAFWQMVWETKVDVIAMVTNEIEGGKLKCHRYWPEEQNSELKLGNLRIISGPARDTATHICKHFMLQNMDTN--ESREIVHLRY
|. .|||.| |. |..  ||||||||    | || ..    .     |||  ...  | |.| . .      . .    ..| |  |    .||| | ..
gqrryiatqhplretmadfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqf

TAWPDHGVPESASA---MLSFRKAILKL--QKSDTLLIHCSAGVGRTGTYIAIDTLVRRLEA-GAPNLDPCAVVTEMRRARNFMVQTLVQYQFVFK
|.| ..  |. |     ... |.   |   .|   ...||| | | || ..|.|  ||  |   .  .|   |   .|.||  .. .| .|.|...
tswkekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiyq
subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 109-296 4.7e-23 76.4 In-house 2-197 (198) alignment 
Range on Protein: 109-296
Range on HMM: 2-197/198.0
GETKYIAAQGPVPESFYAFWQMVWETKVDVIAMVTNEIEGGKLKCHRYWPEEQNSELKLGNLRIISGPARDTATHICKHFMLQNMDTN--ESREIVHLRY
|. .|||.| |. |..  ||||||||    | || ..    .     |||  ...  | |.| . .      . .    ..| |  |    .||| | ..
gqrryiatqhplretladfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqf

TAWPDHGVPESASA---MLSFRKAILKL--QKSDTLLIHCSAGVGRTGTYIAIDTLVRRLEA-GAPNLDPCAVVTEMRRARNFMVQTLVQYQFVFK
|.| ..  |. |     ... |.   |   .|   ...||| | | || ..|.|  ||  |   .  .|   |   .|.||  .. .| .|.|...
tswkekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiyq
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 51-303 1e-22 75.4 In-house 13-260 (267) alignment 
Range on Protein: 51-303
Range on HMM: 13-260/267.0
EEYSKFAAIQGVAHASFTEENVNKNRYRNISAYDHTRVKITPNPHNgmsdYVNANYIPG---ETKYIAAQGPVPESFYAFWQMVWETKVDVIAMVTNEIE
|.  | . ..     |..|.| ..||. .   ||.||| .  . ..    |.|| |. |   . ..|. |.|.  .   |.... . || || ..|.  .
elikkisdtsstisqsiaeknqernrlddnlpyddtrvilrtkeee....yinasyvegyktknafivtqdplkntitdfltvihdqkvpvivlltkvft

GgklKCHRYWPEEQNSELKLGNLRIISGPARDTATHICkhFMLQNMDTNESREIVHLRY-TAWPDHGVPESASAMLSFRKAILKLQK-SDTLLIHCSAGV
.   . ...|| .     |  .| .     ..   .      |.    |||   | | |   |      .     |    |  .|.. .  |...||.||
d...nirlfwPPkmgqakkyqdltvehslekeendyqi..itlelkfknesahnvtlyyykkwnintnnkpylkplfgilaknqlengnrPlvvacsdGv

GRTGTYIAIDTLVRRLEAGApNLDPCAVVTEMRRARNFMVQTLVQYQFVFKALLEVIN
||.||.. ||. ..|.      .|    . ..|  |  .|.|. .| .. . | |  .
GrsGtflvidsqlerakteg.vsdifdflrkirsqriglvdtkeryiyihellaeyae
0048179 (Phosphotyrosine protein) phosphatases II 194-295 8e-22 72.9 In-house 42-138 (144) alignment 
Range on Protein: 194-295
Range on HMM: 42-138/144.0
DTNESREIVHLRYTAWPDHGVPESASAMLSFRKAILKL-QKSDTLLIHCSAGVGRTGTYIAIDTLVrrleagAPNLDPCAVVTEMRRARNFMVQTLVQYQ
 . . ||.... .. |||||||.... .|.| ..| .. ...   |.|||||||||||..|.. ..        .|..  .. ..|..| ..|..  |..
pefleregiqylhlpwpDhgvpdllellleflefieealeeggpvlVHCsaGvgRtgtlvaaylmk......klglsleealalvrsrrpgavpnpgqlr

FVF
|. 
fLl
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 71-171 1.3e-21 71.7 In-house 47-166 (350) alignment 
Range on Protein: 71-171
Range on HMM: 47-166/350.0
NVNKNRYRNISAYDHTRVKIT--PNPHN------GMSDYVNANYIPGE---------TKYIAAQGPVPESFYAFWQMVWETKVDVIAMVTNEIEGGKLKC
   ||||.||  |.|.|||.   ... .        .||.||||.  .          ||||.|.|.|. .  |.... . || || ..|...| .  ||
lfaknrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvkvilsltsdvelnlekc

HRYWPEEQNSE--LKLGNLR
.|||.| . ..  .|| . .
yrYWqegsydditvklaskw
subfamily_hpo-7_pd Subfamily hpo-7 126-303 8.8e-21 69.0 In-house 49-228 (263) alignment 
Range on Protein: 126-303
Range on HMM: 49-228/263.0
AFWQMVWETKVDVIAMVTNEIEGGKLKCHRYWPEEQNSELKLGNLRIISGPARDTATHICKHFMLQNMDTNESREIVHLRYTAWPDHGVPESASAMLSFR
.|.|..  || .|..|...  | |. || .|.| |..  .|| |. . .  . .      .... .  .  . ... |  |. |...  || |  .|   
kfyqtivqtktevvvmLcDfneegvekcssyfPlekdekqklanvnvcttkvqsdvllktlellstlgeKkkthtvkhysykgWiekndpelareilnil

KAIlklQKSDTLLIHCSAGVGRTGTYIAIDTL----VRRLEA-GAPNLDPCAVVTEMRRARNFMVQTLVQYQFVFKALLEVIN
|.    ..|  | .|||.|.||.  .  ....    .| |.   . .||   ...|.|  |.  ..| .|  | .  .|... 
kva...rnskslvvhcstGiGrsaafsvaElvyqkmirsldttstveldylsLleelrssrkraihtPmqLafsilmvLdfvl
subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 65-304 5e-20 66.3 In-house 42-281 (303) alignment 
Range on Protein: 65-304
Range on HMM: 42-281/303.0
ASFTeENVNKNRYRNISAYDHTRVKITPnphngmSDYVNANYIPGET--KYIAAQGPVPESFYAFWQMVWETKVDVIAMVTNEIEGGKLKCHRYWPEEQN
  |  .|..|||. ..   ||..||..       | |. |.|.  ..  | | .| |.. .   ||||. | || .. ..  . |  ||  .  .|..|.
nqfv.knmdknrfvdvicldhskvklsd......ssyihasyleldsskkailtqlplshtaadfwqmiieqkvkcvlllltdseydklggdsvfprnqd

SeLKLGNLRIISGPARDTatHICKHFMLQNM--DTNESREIVHL-RYTAWPDHGVPESASAM-----LSFRKAILKLQKSDTLLIHCSAGVGRTGTYIAI
  ||. .  |  |  .     . . . |. .     . . ..|.  | |||   .|  .|.         .  . |  .|   .    .|.||.||.  .
f.lkfeersirvgefkrv..elgdgwvlkvlsvsngdyksflhvhhykawphnsipsdgspkfvkqiwqlqsvlrkysdstptvymslsgcgragtfalf

DTLVRRLEAGAPNLDPCAVVTEMRRARNFMVQTLVQYQFVFKALLEVINK
.|    | .  . ||   ..  .|  |   || | |. .|.  | | . .
etahlslhseqasldlvkclenvrngrlhavqnlsqfsvvytllaehvld
subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 120-295 2e-19 64.2 In-house 100-281 (302) alignment 
Range on Protein: 120-295
Range on HMM: 100-281/302.0
VPESFYAFWQMVWETKVDVIAMVTNEIEGGKLKCHRYWPEEQNSELKLGNLRIISGPARDTATHI--CKHFMLQNMDTNESR-------EIVHLRYTAWP
  ..   .| .. . .| ... ... .|... ||  |. .. . |||.|.  . .   ..   .    |.|.| ... ....        .  | ..|||
kkstlekhwalieqynvaivvqlcsfvedeekkcaeyysdkvggelkfgrytvktvsvktdleeftdkksfklytveiknekkkkkvkktvdilafsawp

DHGVPESASAMLSFRKAILKLQKSdtLLIHCSAGVGRTGTYIAIDTLVRrLEAGAPNLDPCAVVTEMRRARNFMVQTLVQYQFVF
||| |. | . |   |     .|.  .|.||||||||||| .||   .  | .     |   .|. .|. |   ||.  |  ...
dhGapkeaytaldilkfcesykkn..vlvhcsaGvGrtGtlvaikyGiq.lcskkkvtdllsivlpvrqcryGavqdeqqliyll
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 193-302 4.6e-18 59.8 In-house 83-194 (440) alignment 
Range on Protein: 193-302
Range on HMM: 83-194/440.0
MDTNESREIVHLRYTAWPDHGVPESASAMLSFRKAILKLQK---SDTLLIHCSAGVGRTGTYIAIDTLVRRLEAgAPNLDPCAVVTEMRRARNFMVQTLV
..  ||| . . .| .|||.|||. |. .| . . . . |.   .  ||.|||||.||||  ||.|...|  .  . ..|  ...  ||  |  ||||  
ingiesrtlkqyhyqgwpdkgvpkfagpvlkmiqdvnesqekagngpllvhcsagagrtgviiavdsilreakr.sdqidifsfinsmrnnrpqmvqtpe

QYQFVFKALLEVI
|| ||..|.|| .
qyafvheavlegl
subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 73-322 1.8e-17 58.4 In-house 21-272 (290) alignment 
Range on Protein: 73-322
Range on HMM: 21-272/290.0
NKNRYrNISAYDHTRVKITPNPHNGMSDYVNANYI--PGETKYIAAQGPVPES-------FYAFWQMVWETKVDVIAMVTNEIEGGKL----KCHRYWPE
 ..|. ...   .||| .        .||. ||..  |   . |. | |  .           || |. . ||. . |. .  |  .      | .| ||
mdqRl.evpLveatrvvLkgygkrfnddyiHAnrvtcpnglrliltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCakYvpe

EQNSELKLGNLRIISgPARDTATHICKHFMLQNMDTNESREIVHLRYTAWPDHGVPESASAMLSFRKAILklQKSDTLLIHCSAGVGRTGTYIAIDTLVR
. . |||...| .     . .   . .  .. . | .|   . | ..  | .  |.|.   .||  . .   ..  . ..||  |. |  .  ||.    
svgeelkfkgltvkC.kskekeddvetRelvvkfddeeeftvtHsllkgWnklnvqedtktllsliqkvk..asktpvivHcvdGiSrsAalaaiilgyQ

RLEAGAPNLDPCAVVTEMRRARNFMVQTLVQYQFVFKALLevinkylLRAKKALAEVKGRADE
 .     ..   .|. ..|. |. ....  .. ||  ...       |.|...| ..   ..|
kiaetsgsvkledvlkalrkqralaitsalelafvdagiv.......llaievldqfaeeete
subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 69-305 1e-16 55.2 In-house 49-288 (302) alignment 
Range on Protein: 69-305
Range on HMM: 49-288/302.0
EENVNKNRYRNISAYDHTRVKITPNPhngmSDYVNANY--IP-GETKYIAAQGPVPESF---YAFWQMVWETKVDVIAMVTNEIEGGKlKCHRYWPEEQN
 .|..||.  .. ..|...||.. .|     .||||    .|  . . | || |. .|      ||.||.. |.  . ..  | |  |   . ..|....
kknlkknqsedvpildsnlvkleaep....dsyvnaskvevPeltrsiilaQlpkvdsedsveeFWrmvfqekivsvvilvgeeelkk.tlselfpkksg

SELKLGNLRIISGPARDTATHIcKHFMLQNMDTNESREIVHL--RYTAWPDHGVPESASAMLSFRKAI--LKLQKSDTLLIHCSAGVGRTGTYIAIDTLV
. .. |....       .  .  .....  .  . |  ..      | |... ||.. ...    . .  .| . .....|    |.|| |. ..  . |
dykeygkmfvNnrkVekaeeek.tryviEvlPegcsnsvlanvyvltnWkqkkvpvkyaeliktaakvfakkikadentvivSknGaGRagafltlavav

RRLEAGaPNLDPCAVVTEMRRARNFMVQTLVQYQFVFKALLEVINKY
 .|..|  .     .|. .|  |  .|..| || ... |||  | | 
eklqkg.kepnikeivksiRsqRpravdslkQyvslyialllyikkk
subfamily_eak_pd Subfamily eak 41-227 4.4e-16 53.2 In-house 23-206 (332) alignment 
Range on Protein: 41-227
Range on HMM: 23-206/332.0
LSTNQNRGWIEEYSKFAAIQGVAHASFTeENVNKNrYRNISAYDHTRVKITPNPHNGmSDYVNANYIP---GETKYIAAQGPVPESFYAFWQMVWETKVD
   ||    .... ..  .. .  .. . |.||.|   .|  ||.  |..|.   |    |.||  .       ||| .  .  .  .|||||| | |  
nrinqrinivadlddyqrllsisetarl.eavnrn.vvkivpydrylvrltssqlnr.lGyinaslaefsevGrkyiltGiasedkvfafwqmvleqksp

VIAMVTNEIEGGKLKCHRYWPEEQNSELKLGNLRIISGPArdTATHICKHFMLQNMDTNESREIVHLRYTAWPDHGVPESAsAMLSFRKA
 | .. ...| .  |  .|.|..   ||| | | .           | .  .|.    ||. .. | ..  | .  .|     .|..||.
aivqlledvelkleksdkyfpdktreelkfGildverkef..vkrniletrllelskGnethrvlhykvfGwtettlpkye.dflalrkv
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 70-169 3e-14 47.1 In-house 47-167 (349) alignment 
Range on Protein: 70-169
Range on HMM: 47-167/349.0
ENVNKNRYRNISAYDHTRVKITPNPH--NG------------MSDYVNANYI-----PGETKYIAAQGPVPESFYAFWQMVWETKVDVIAMVTNEIEGGK
|   ||||..|  |.|.|||.   ..  ..            . ||.||||.       | |||| | |.| .   |....   .| ..  .... | . 
elfaknrykdilPyehsrvklkkslksskvikastsesdsgklddyinanylkltrisvekkyiatqaPlPstvddfykvillngvklvlsLnddkelsl

LKCHRYWPEEQNS--ELKLGN
 ||..|| | . |  ..|| |
ekcdiywqelsysnitvklqn
subfamily_CG42327_pd Subfamily CG42327 236-300 3.5e-14 47.2 In-house 249-313 (319) alignment 
Range on Protein: 236-300
Range on HMM: 249-313/319.0
TLLIHCSAGVGRTGTYIAIDTLVRRLEAGAPNLDPCAVVTEMRRARNFMVQTLVQYQFVFKALLE
 | .||| ||||||. || |  .|.||     .|   .|  .|| |   |.|  ||.|..| | |
PlvvhcsdGvGrtGlviasdiairsleeskrsvdiPqlvssvrrdrasavltkeqyefiykvlse
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 201-300 3.6e-13 44.0 In-house 217-342 (350) alignment 
Range on Protein: 201-300
Range on HMM: 217-342/350.0
IVHLRYTAWPDH---GVPESASAMLS---------FRKAILKLQKSDTLLIHCSAGVGRTGTYIAIDTLVR-------------RLEAGAPNLDPC-AVV
. .|..  |.|      |||   .|          | .  |. ..|...|.|||||||||||....| |.              .|.  |   |.   .|
vyqlqvknWkDlslllnPesilqalevkndliddlfaeshldnarsspilvhCsaGvGrtGtlvtlDsllsdfeilenltkesrkldvaaktrDlisiiv

TEMRRARNFMVQTLVQYQFVFKALLE
 |.|. |  |||.| |. |...||| 
nelrkqrismvqnldqfifiYeallf
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 234-301 1e-11 39.3 In-house 228-294 (297) alignment 
Range on Protein: 234-301
Range on HMM: 228-294/297.0
SDTLLIHCSAGVGRTGTYIAIDTLVRRLEAGApNLDPCAVVTEMRRARNFMVQTLVQYQFVFKALLEV
.  ||.||||||||.|  .  |... .|  .    |  |... .|  |  .|||| |......| |. 
nayllvhcsaGvGrsGvvvlsdvilaklrkkr.ipdvaailsilreqrarlvqtleqfellydavlkk
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 198-300 7.8e-11 35.9 In-house 217-342 (349) alignment 
Range on Protein: 198-300
Range on HMM: 217-342/349.0
SREIVHLRYTAWPDHGV---PESASAMLS---------FRKAILKLQKSDTLLIHCSAGVGRTGTYIAIDTLVR----------RLEAGAPNLDPCA-VV
  |.. |..  |.| ..   | |    |          | .  |. ... |||.||||| ||||... .| |.           ...  |   |.   .|
PyellqlqvknwldlslllnPisilqalevkndliddlfarlyldtdqlstllvhcsaGcGrtGvlvtldlllsileplqnesnkiklqallkDlisiiv

TEMRRARNFMVQTLVQYQFVFKALLE
 |.|. |  ||| | |. ....|||.
nelrkqrismvqnlaqfiaiyealLk
subfamily_Sponge-PTP-7_pd Subfamily Sponge-PTP-7 238-302 3.3e-10 34.2 In-house 2-65 (69) alignment 
Range on Protein: 238-302
Range on HMM: 2-65/69.0
LIHCSAGVGRTGTYIAIDTLVRRLEAGApNLDPCAVVTEMRRARNFMVQTLVQYQFVFKALLEVI
..|||.| |||||.|||   . |. .    .|    |  ||. |  ||   ..| |.  || | .
vvhcssgtgrtgtfiaimvemariksek.lvdifnnvqymrkcrpmmvmneieyifihdalveal
subfamily_Sponge-PTP7_pd Subfamily Sponge-PTP7 239-302 1e-09 32.6 In-house 2-64 (69) alignment 
Range on Protein: 239-302
Range on HMM: 2-64/69.0
IHCSAGVGRTGTYIAIDTLVRRLEAGApNLDPCAVVTEMRRARNFMVQTLVQYQFVFKALLEVI
.|||.| |||||.|||   . |. .    .|    |  ||. |  ||    .| |.  || | .
vhcssGtGrtGtfiaimvemariksek.lvdifnnvqymrkcrpmmvmneneymfihdalveal
subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 68-143 1.5e-09 31.8 In-house 34-117 (347) alignment 
Range on Protein: 68-143
Range on HMM: 34-117/347.0
TEENVNKNRYRNISAYDHTRVKITPNP-HNG----MSDYVNANYIP---GETKYIAAQGPVPESFYAFWQMVWETKVDVIAMVT
 | ...||| ..    | ||| ..|.  .|.    .  |.|| .|     ...|| .| |.|..   ||.||  |||  .  . 
wekslsknrskdvklidatrvvlspeksknsraddvetyinashikfdnaskeyiltqyplpdtvrdfwkmvsvtkvtqvvtif
subfamily_Sponge-PTP3_pd Subfamily Sponge-PTP3 36-118 4.4e-09 30.4 In-house 12-95 (95) alignment 
Range on Protein: 36-118
Range on HMM: 12-95/95.0
RHAERLSTNQNRGWIEEYSKFAAIQGVAHA-SFTEENVNKNRYRNISAYDHTRVKITPNphnGMSDYVNANYIPGETK---YIAAQG
 |   . .| .. . .|.   .   | ...   .| |. |||. ||  || ||| .| .     |||.|| .. | ..   ||||||
shvlemhsnsdqefdnefksismtsgapytvgsseanipknrflnifpydatrvvlttk...rdsdyinacfvdgyarkncyiaaqg
subfamily_Cele-PTP-12_pd Subfamily Cele-PTP-12 70-143 1.1e-08 28.9 In-house 33-108 (332) alignment 
Range on Protein: 70-143
Range on HMM: 33-108/332.0
ENVNKNRYRNISAYDHTRVKITPnpHNGMSDYVNANYIPGETK---YIAAQGPVPE-SFYAFWQMVWETKVDVIAMVT
.|.. ||   . ..||.||...|  ..|  |. ||... | .|   || || |. . . | ||.|| | |  .| .. 
nnmdmnriphlycfdhsrvelap..qdgkddfynaswvdgyskksayifaqapfndhteyvfwrmvserkpsmilvfg
0038934 (Phosphotyrosine protein) phosphatases II 203-297 1.1e-08 30.5 In-house 81-172 (194) alignment 
Range on Protein: 203-297
Range on HMM: 81-172/194.0
HLRYTAWPDHGVPESASAMLSFRKAILKLQKS---DTLLIHCSAGVGRTGTYIAIdTLVRRLeagapNLDPCAVVTEMRRARNFMVQTLVQYQFVFKA
.     .||.|.. | . .|.| ... .  .     . ..|| ||.||||| .|   |. ||     .... . .  .|..|. ....  ... ..| 
eylklpfpddgtvPsleillrfldlvdeflnedpggvvaVHCkaGlgRtGtlvaa.YLiyrl.....gmsaeeAialfrekRpgaipnqdyleallkr
PTEN_1 198-253 4.9e-08 28.0 In-house 91-149 (196) alignment 
Range on Protein: 198-253
Range on HMM: 91-149/196.0
SREIVHLRYTAWPDHGVPESASAMLSFRKAILKLQK---SDTLLIHCSAGVGRTGTYIA
 .. |  .   ..|||.|  .. .   ...|  |..     . |.|| ||.||.|| .|
fksgveylhfpieDhgapslselfdicksfiewllsdpngnvVlVHCkaGlgRsGtvva
subfamily_PTPDC1_pd Subfamily PTPDC1 198-294 8.7e-08 26.8 In-house 80-168 (182) alignment 
Range on Protein: 198-294
Range on HMM: 80-168/182.0
SREIVHLRYtAWPDHGVPeSASAMLSFRKAILKLQKSDTLLIHCSAGVGRTGTYIAIdTLVRRLeagapNLDPCAVVTEMRRARNFMVQTLVQYQFV
 ..|..  . .|.|.||. |   .|   | .    . . . .|| || ||||  ||   ||        .|..   .. .|  |   .||  | ..|
eqgiyvynf.gwkDygva.sleriLdivkvvafalqegkvavhChaGlGrtGvliac.ylvyak.....rltaekaiklvrskrpksiqtreqvelv
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 46-109 2e-07 24.7 In-house 21-85 (440) alignment 
Range on Protein: 46-109
Range on HMM: 21-85/440.0
NRGWIEEYSKFAA--IQGVAHASFTeENVNKNRYRNISAYDHTRVKITPNPHNGMSDYVNANYIPG
 | . .|.| . .   |    ||.  .|  ||||||| ||||.|| .        |||.|| || |
srafedewsllpsglsqpsdiaslp.nnkvknryrnilaydhsrvmleevkgvpdsdyinasying
subfamily_Sponge-PTP-2_pd Subfamily Sponge-PTP-2 70-217 2.6e-07 23.7 In-house 26-157 (169) alignment 
Range on Protein: 70-217
Range on HMM: 26-157/169.0
ENVNKNRYRNISAYDHTRVKITPNPHNGMSDYVNAnyipgetkyiaaqgpvpesfyafwQMVWETKVDVIAMVtneieGGKLKCHRYWPEEQNSELK---
 |  |||     |  |||||.    ..  |||.||                        .|.|||   || ..     |.      .||| .. .|.   
cnetknrpagplapshtrvklqrvmedlgsdyina........................rmiwetnasvivvl.....gdtddknnfwpekedyqlhpav

-LGNLRIISGPARDTATH-ICKH--------FMLQNMDTNESREIVHLRYTAWPDHGVPES
 ||.    |   |    |  ..         ..... | . . ..  | |..||. |||.|
ilgewytdslyvrtdkvhantsgveglfevsmvihsydddvteklsllhystwpqngvpqs
subfamily_Sponge-PTP2_pd Subfamily Sponge-PTP2 71-171 5.2e-07 22.6 In-house 26-101 (169) alignment 
Range on Protein: 71-171
Range on HMM: 26-101/169.0
NVNKNRYRNISAYDHTRVKITPNPHNGMSDYVNAnyipgetkyiaaqgpvpesfyafwQMVWETKVDVIAMVtneieGGKLKCHRYWPEEQNSELK----
|  |||     |  |||||.     .  |||.||                        .|.|||   || ..     |.      .||| .. .|.    
netknrpagplapshtrvklqrvmedlgsdyina........................rmiwetnasvivvl.....Gdtddknnfwpekedyqlhpavi

LGNLR
||.  
lGewy
subfamily_eak_pd Subfamily eak 220-316 7.8e-07 22.8 In-house 222-315 (332) alignment 
Range on Protein: 220-316
Range on HMM: 222-315/332.0
AMLSFRKAILKLQKSDTLLIHCSAGVGRTGTYIAIDTLVRRLEAGAPNLDPC-AVVTEMRRARNFMVQTLVQYQFVFKALLevinKYLLRAKKALAEV
 . |. |   .   | . .| .. |  |.|... || |.| ...   ||     ..  ..  |.  | .  |. |.....|    .|||| .. | ..
llsstlkkyihtppsfapiiqsarGsaraGvfvvidllirlidnkkknlysvedlilkvkskrihsvlvalqhsfiyeivl....dyllrrnnrlrdl
subfamily_CDKN3_pd Subfamily CDKN3 205-295 1.1e-06 22.3 In-house 103-189 (202) alignment 
Range on Protein: 205-295
Range on HMM: 103-189/202.0
RYTAWPDHGVPESASAMLSFRKAILKLQKSDTLLIHCSAGVGRTGTYIAidTLVRRLEAGAPNLDPCAVVTEMRRARnfMVQTLVQYQFVF
 .   .| .||. || .  . .  . |..    |.||  |.||.   ||   |.  |.      |  . . ... .|   .||. ||... 
hhypiadglvpdiasclkileelrinlkayrktlvhcygglgrsslvia..clllylddtiepkdaidklrdlkgsr..aiqtvkqynyls
subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 68-112 1.4e-06 22.1 In-house 36-79 (244) alignment 
Range on Protein: 68-112
Range on HMM: 36-79/244.0
TEENVNKNRYRNISAYDHTRVKITPNPHNGmSDYVNANYIPGETK
   |. |||| ||  .|.||| .. . ..| |||.||||| |  .
lsanatknryinilpfdetrvilssskkeg.sdyinanyiqgsqn
DUF4615 Domain of unknown function (DUF4615) 461-539 1.7e-06 14.8 Pfam-A 26-99 (124) alignment 
Range on Protein: 461-539
Range on HMM: 26-99/124.0
KQAHggeeyDVSQSFTPLESRILALAQQREVMALKSDDVRRKMEEEEFARITSLTHRIKSLASERLEDRTKWADRPRKS
|||.     ....  . |.|.  .|.. | ||     | |.||||||    . | .  .| . .  .. .| .   .||
kqae.....ealkalktLksekaplvkKrqvmrstfGdYrakmeeeekkllkalesakfsakvkevaeakkkskfvkks
PTPlike_phytase Inositol hexakisphosphate 164-259 2.4e-06 22.3 Pfam-A 80-149 (149) alignment 
Range on Protein: 164-259
Range on HMM: 80-149/149.0
ElklgnlriisgpardtathickhfMLQNMDTNESREIVHLRYtAWPDHGVPESaSAMLSFRKAILKLQKSDTLLIHCSAGVGRTGTYIAIDTLVR
|                         . .... |. ..   |  . .|.  ||  .   .| ..| .|.... |...|.|| ||| |...| .|.|
e........................evyeeelaegfgvkYvRi.pitdeqapee.edvDafvrlikslprdtalvfnCqaGrgRTTtamviadLlr
PTPlike_phytase Inositol hexakisphosphate 164-259 2.4e-06 22.3 In-house 80-149 (149) alignment 
Range on Protein: 164-259
Range on HMM: 80-149/149.0
ElklgnlriisgpardtathickhfMLQNMDTNESREIVHLRYtAWPDHGVPESaSAMLSFRKAILKLQKSDTLLIHCSAGVGRTGTYIAIDTLVR
|                         . .... |. ..   |  . .|.  ||  .   .| ..| .|.... |...|.|| ||| |...| .|.|
e........................evyeeelaegfgvkYvRi.pitdeqapee.edvDafvrlikslprdtalvfnCqaGrgRTTtamviadLlr