Gene MbrePTP-sf1-4 in Monosiga brevicollis

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily MbrePTP-sf1
Protein sequence
ID Type Fasta BLAST phosphatome Note
MbreP035_AA protein Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 2-250 3.6e-116 382.2 In-house 20-265 (281) alignment 
Range on Protein: 2-250
Range on HMM: 20-265/281.0
RYQDFYDIGRDQPATASYANPNLLKNRYGNIVAYDAGRVKLSQIGDDPSTDYINASWVDAYKQPNGYIASQGPVPNSFLDFWRMVWEQNACTIVMVTHEV
 |.....||.|..||||.|. | ||||| |||||||.|||...  .. .||||||..|..||....|||.|||||.|. .||.|||||....|||||.|.
eyeklaaigvdntataskadenvlknrYsnivaYDatrvkvtpneenkntDYinanfvpgykgekeyiatqgPvPaslvafWqmvweqkvsaivmvtrei

EKGRIKCHRYWPDPTStpptqTLSYGDVTVTHLRAEAHRHFVVRTFLV-RCNSEERTVKQFAYTSWPDHGVPLTTAELLGFRNAV-NAGTPNKDVPIVIH
|.|..||||||||..|     .|.||||||.....|...... |.| . |...|.|.|.|.|||.||||||| ||.|||.||..| .. ......|.|||
eagklkChrYWPddns.....elkygdvtvkstaeeekatyierkfkleresgetreveqlaytaWPdhGvPattkellefrkevlkltekktkaplvih

CSAGVGRTGTYIAIDTLVKQCLDMGGMPNVDAVVRDMRLRRNYMVQTEVCI
|||||||||||||.|.|||.. ..  . .|.|||...| .||.|||| |. 
CsaGvGrtGtyialDrlvkaveaeleeldvkavvaelrkernlmvqtvvqy
subfamily_PTPRD_pd Subfamily PTPRD 11-247 2.1e-93 308.9 In-house 36-267 (564) alignment 
Range on Protein: 11-247
Range on HMM: 36-267/564.0
RDQPATASYANPNLLKNRYGNIVAYDAGRVKLSQIGDDPSTDYINASWVDAYKQPNGYIASQGPVPNSFLDFWRMVWEQNACTIVMVTHEVEKGRIKCHR
.  . .|. .. |  |||| ||||||. ||.||..  |...||||||..|.|.... |||.|||..... |||||||||| .||||.|. .|||. |||.
qqftweaankpaNkaKNRyanivaYdhsRVvLskvegdegsDYINAsfidgyrkrkayIAtqgPlaetiedFWRmvweqnsstiVmltkleEkgkvkchk

YWPDptstppTQTLSYGDVTVTHLRAEAHRHFVVRTFLV--RCNSEERTVKQFAYTSWPDHGVPLTTAELLGFRNAVNAGTPNKDVPIVIHCSAGVGRTG
|||.      ..| .||..|||    |   ....||| .    .|| |.|.|| .||||||||| ....|| ... |.| ....  |||.||||||||||
YWPe......kgtetygeltVtleeeeeladyeirtfklkkkkssesreVrqFhFtsWPdhgvpesatslLdlirkvralnepdagPivVhCSaGVGRTG

TYIAIDTLVKQCLDmGGMPNVDAVVRDMRLRRNYMVQTE
|.|.|| ....  .  .. ..  .|. .|  ||.|||||
tfividamlerike.ektvDiyqyvkalrkqRnamVqte
subfamily_PTPRB_pd Subfamily PTPRB 2-247 6.2e-89 292.9 In-house 30-271 (293) alignment 
Range on Protein: 2-247
Range on HMM: 30-271/293.0
RYQDFYDIGRDQPATASYANPNLLKNRYGNIVAYDAGRVKLSQIGDDPSTDYINASWVDAYKQPNGYIASQGPVPNSFLDFWRMVWEQNACTIVMVTHEV
.|... ..|.||  .|. .. |  |||| ||..||. ||||... |....|||||.... |..|. .||.|||.|... ||||||||... .|||.|. |
eyeelkavgkdqavkaaelavnraknrytnilpydhsrvkLaalkdesgsDYinanyipgynsprefiatqGPlpetvddfWrmvwekkssiivmltqlv

EKGRIKCHRYWPDPtstppTQTLSYGDVTVTHLRAEAHRHFVVRTFLVRCNSEERTVKQFAYTSWPDHGVPLTTAELLGFRNAVNAGT--PNKDVPIVIH
|||..||..|||.      ...  |||..|| .  |  ...|.|..... ..|||.|.|. .||||||||| .|. || | ..|.  .   ... |||.|
ekgkvkCeeYWPad.....eepvlyGdikvtlvaeeeledwvirelkiekekeerkvrqyhftsWpdhgvPektktlldfvrtvreaiektaskrPivvh

CSAGVGRTGTYIAIDTLVKQCLDmGGMPNVDAVVRDMRLRRNYMVQTE
||||||||||.||.|.|...  .   . .. ..| ..| .||..||||
CsaGvGRtGtfialdrllqaiee.edyvdifgivaelReeRnllvqte
0051299 (Phosphotyrosine protein) phosphatases II 2-247 7.7e-85 280.1 In-house 28-272 (288) alignment 
Range on Protein: 2-247
Range on HMM: 28-272/288.0
RYQDFYDIGRDQPATASYANPNLLKNRYGNIVAYDAGRVKLSQIGDDPSTDYINASWVDAYKQPNGYIASQGPVPNSFLDFWRMVWEQNACTIVMVTHEV
 .......  | . .|..   || |||| .|..||  ||||| .......||||||..| |.... .|| ||| ||.. ||||||||||  .|||.| .|
efeellsllpdltlsaallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyidgynlkrkfIatqgPlpntvedFWrmvweqnvrvIvmltklv

EKGRIKCHRYWPDptstppTQTLSYGDVTVTHLRAEAHRHFVVRTFLVR------CNSEERTVKQFAYTSWPDHGVPLTTAELLGFRNAVNAGTPNKDVP
|.||.||..|||.       ..| |||.||| |. | . ...|||. |.      ...|.|||..| ||.||||||| .. .|| | ..|.   .... |
elgrekcaqYwpl......ggsltygditvtllseevlddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpdspellldflrlvrkalasgggp

IVIHCSAGVGRTGTYIAIDTLVKQCLDMgGMPNVDAVVRDMRLRRNYMVQTE
.|.|||||||||||.||.|.|. | .   |...|  .|. .| .|..||||.
vvVHCsaGvgRtgtfialdllleqleke.ggvdvleavkrlreqRpgmvqtp
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 12-247 1.2e-83 275.8 In-house 35-266 (318) alignment 
Range on Protein: 12-247
Range on HMM: 35-266/318.0
DQPATASYANPNLLKNRYGNIVAYDAGRVKLSQIGDDPSTDYINASWVDAYKQPNGYIASQGPVPNSFLDFWRMVWEQNACTIVMVTHEVEKGRIKCHRY
   .. |  . |  |||| ||.|||  ||||... .....|||||...| |.. . |||.|.|.|. . ||||||||||...|||.|.|.|.|..|.|||
tvtslkslepvnkaknryanilaydhtrvkLqmlegeegsDyinanyidGyrrkkayiaaqaPlpetieDfWrmvWeqnsavivmltqeeergkakvhry

WPDptstppTQTLSYGDVTVTHLRAEAHRHFVVRTFLVRCN--SEERTVKQFAYTSWPDHGVPLTTAELLGFRNAVNAGT-PNKDVPIVIHCSAGVGRTG
||.       .. |||...|.        ..|.|.| |. .  .|.|.|.|. ||||||.|||  .|.|| .   |..   ...  |||.||||||||||
WPs......kgsrsygklvvelkeevelsdyvlrefkvtrteeeesrqvrqyhytsWpdegvpesgaslldlvrqvskaqqksgagpivvhCsaGvGrtG

TYIAIDTLVKQcLDMGGMPNVDAVVRDMRLRRNYMVQTE
..||.|.|... .   .. .|  .|. .| .|| |||||
vfiavdiller.ikaealvDvfqtvkqlreqrnlmvqte
0050432 (Phosphotyrosine protein) phosphatases II 3-247 1.6e-82 272.6 In-house 48-285 (308) alignment 
Range on Protein: 3-247
Range on HMM: 48-285/308.0
YQDFYDIGRDQPATASYANPNLLKNRYGNIVAYDAGRVKLsqigdDPSTDYINASWVDAY--KQPNGYIASQGPVPNSFLDFWRMVWEQNACTIVMVTHE
.......  . . ....   |  |||| .|..||  ||||     |...||||||.|| |  |.|. .|| ||| ||.. ||||||||||  .|||.| .
feellsvkplleysvallpenkdkNrykdilpydhsRVkl.....degsdYInAsyvdgyssklprkfIatqgPlpntvedFwrmvweqnvrvIvmLtkl

VEKGRIKCHRYWPDPTSTpptQTLSYGDVTVTHLRAEAHRHFVVRTFLVRC--NSEERTVKQFAYTSWPDHGVPLTTAELLGFRNAVNAGTpnKDVPIVI
||.||.||..|||. .     ..| ||..|||.|. | . ...|||. ...  ..|.|||..| ||.|||||||  ...|| | ..|.     .. |||.
vengrekcaqYwplelgg...gsleygkftvtllseevlddytvrtleltnlgdgesrtvthfhytnWpdhgvPpspeilldflelvrksl..pggpivV

HCSAGVGRTGTYIAIDTLVKQCLDMgGMPNVDAVVRDMRLRRNYMVQTE
|||||||||||.||.|.|. |     |...|  .|. .| .|..||||.
HCsaGvGRtGtfialdllleqleke.ggvdvfeavkklReqRpgmvqtp
0040438 (Phosphotyrosine protein) phosphatases II 3-247 8.9e-82 270.2 In-house 24-262 (317) alignment 
Range on Protein: 3-247
Range on HMM: 24-262/317.0
YQDFYDIGRDqPATASYANPNLLKNRYGNIVAYDAGRVKLSQIGDDPSTDYINASWVDAYKQPNGYIASQGPVPNSFLDFWRMVWEQNACTIVMVTHEVE
..|....  | . . ..   |  |||| .|. ||. ||||| .| |...||||||.|| ..... .|| ||| ||.. |||||||||. ..|||.|...|
fedllslkld.tysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyvdgpnlkrkfIatqgPlpntvedFwrmvweqgvtvivmLtelee

KGRIKCHRYWPDptstppTQTLSYGDVTVTHLRAEAHRHFVVRTFLVR--CNSEERTVKQFAYTSWPDHGVPLTTAELLGFRNAVNAGTPNKDVPIVIHC
.||.||..|||.       .|| |||.|||.|  | . ....||. |    .||.|||..| ||.||||||| .. .|| | .||..  .... |...||
lgrekcaqYwpl......getltygdftvtllseeelagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfleavrealedpggpvlVHC

SAGVGRTGTYIAIDTLVKQCLDMGgMPNVDAVVRDMRLRRNYMVQTE
|||||||||.||..... |.   |  ..|. .|. .| .|...|||.
saGvgRtGtfiaaylmleqlekeg.gvdveeavkelreqRpgavqtp
0046845 (Phosphotyrosine protein) phosphatases II 13-247 1.4e-80 266.0 In-house 18-260 (284) alignment 
Range on Protein: 13-247
Range on HMM: 18-260/284.0
QPATASYANPNLLKNRYGNIVAYDAGRVKLSQIGDD-PSTDYINASWVDAY-----KQPNGYIASQGPVPNSFLDFWRMVWEQNACTIVMVTHEVEKGRI
 . .....  || |||| .|..||  ||||. ...| ...||||||.|| |     .... .|| |||.||.. ||||||||||. .|||.| .||.||.
lslsvallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweqnvrvIVmltelvengre

KCHRYWPDPtstppTQTLSYGDVTVTHLRAEAHRHFVVRTFLVRC---NSEERTVKQFAYTSWPDHGVPLTTAELLGFRNAVNAGTP--NKDVPIVIHCS
||..|||.       ..| |||.||| |. | . ...|||. ...   ..|.|||..| |||||||||| ... || | ..|.   .  ... |||.|||
kcaqYwple.....gevltygdftvtllseevkddytvrtleltnlgytgesrtvthfhytswpdhgvppspedlleflrlvrellenlpgggpivVHCs

AGVGRTGTYIAIDTLVKQCLDMGG--MPNVDAVVRDMRLRRNYMVQTE
||||||||.||.|.| .|    |   ...|  .|. .| .|..||||.
aGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtl
0036941 (Phosphotyrosine protein) phosphatases II 3-247 2.7e-79 261.9 In-house 19-263 (297) alignment 
Range on Protein: 3-247
Range on HMM: 19-263/297.0
YQDFYDIGRDQPATASYANPNLLKNRYGNIVAYDAGRVKLsqigDDPSTDYINASWVDAYKQPNGYIASQGPVPNSFLDFWRMVWEQNACTIVMVTHEVE
.......  . . ...    || |||| .|..||  ||||    ||...||||||.|| |.... .|| ||| ||.. ||||||||||  .|||.| .||
feellpllllgslsvallpenleknRykdilpydhtRVkl....ddegsdYinAsyvdgydlkrkfIatqgPlpntvedFWrmvweqnvtvIvmltelve

KGRIKCHRYWPDPtstpPTQTLSYGDVTVTHLRAEA--HRHFVVRTFLVRC--NSEERTVKQFAYTSWPDHGVPLTTAELLGFRNAVNAGTPN--KDVPI
.||.||..|||.       ..| |||.||| |. |   . ....||. | .  |.|.|||..| ||.||||||| ..|.|| | ..|.   ..  .. |.
lgrekcaqywple....egesltygdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfielvrkvlkllpsggpv

VIHCSAGVGRTGTYIAIDTLVKQCLD--MGGMPNVDAVVRDMRLRRNYMVQTE
..||||||||.||.||.|... |  |  . | ...  .|. .| .|. .|||.
lVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtl
0047943 (Phosphotyrosine protein) phosphatases II 3-247 8.1e-79 260.2 In-house 18-258 (273) alignment 
Range on Protein: 3-247
Range on HMM: 18-258/273.0
YQDFYDIGRDQPATASYANPNLLKNRYGNIVAYDAGRVKLsqigDDPSTDYINASWVDAYKQPNGYIASQGPVPNSFLDFWRMVWEQNACTIVMVTHEVE
.......  . . ....   |. |||| .|..||  ||||    .|...||||||.|| |.... .|| ||| ||.. ||||||||||. .|||.| .||
felllslkplltysvallpenkdknrykdilpydhsrvkl....gdggsdyinAsyvdgynlkrkfiatqgPlpntvedfwrmvweqnvrviVmLtelve

KGRIKCHRYWPDPTSTpptQTLSYGDVTVTHLRAEAHRHFVVRTFLVRC--NSEERTVKQFAYTSWPDHGVPLTTAELLGFRNAVNAGTPN--KDVPIVI
.||.||..|||.   .    .| ||..|||.|. | . ...|||. ..   ..|.|||..| ||.||||||| ....|| | ..|.    .  .. |.|.
lgrekcaqYwplegge...lsltygkftvtllseetkddytvrtleltnlgtgesrtvthfhytgwpdhgvppslesllefielvrkalealpsngpvvV

HCSAGVGRTGTYIAIDTLVKQCLDMgGMPNVDAVVRDMRLRRNYMVQTE
|||||||||||.||.|.|. |     |...|. .|. .| .| .||||.
HCsaGvgRtgtfialdllldqleke.ggvdvleavkllrsqRpgmvqtp
0043336 (Phosphotyrosine protein) phosphatases II 3-247 1.2e-78 259.7 In-house 26-263 (278) alignment 
Range on Protein: 3-247
Range on HMM: 26-263/278.0
YQDFYDIGRdQPATASYANPNLLKNRYGNIVAYDAGRVKLSQIGDDPSTDYINASWVDAYKQPNGYIASQGPVPNSFLDFWRMVWEQNACTIVMVTHEVE
.......    . . ..   |  |||| .|..||  ||||| .| |...||||||.|| |..|...||.||| |... ||||||||..  ||||.| .||
feellsfkl.dtysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyvdgynvprkfiatqgPlpetvedFwrmvwelgvttivmLtelve

KGRIKCHRYWPdptstppTQTLSYGDVTVTHLRAEAHRHFVVRTFLVR--CNSEERTVKQFAYTSWPDHGVPLTTAELLGFRNAVNAGTPNKDVPIVIHC
.||.||..|||        ..| |||.||| |. | . ...|||. |    ..|.||| .. |..||||||| ... || | .||.   .... |...||
lgrvkcaqYwp.......ggsltygdftvtllkeehlddytvrtlevtnlgdgesrtvthyhylgwpdhgvpeslsllldflkavrealedsngpvlVHC

SAGVGRTGTYIAIDTLVKQCLDMGgMPNVDAVVRDMRLRRNYMVQTE
|||||||||.||...|. |  . |  .... .|...| .|  .|||.
saGvgRTGtfialyllleqlekeg.gvdleeavkelreqRpgavqtp
0039614 (Phosphotyrosine protein) phosphatases II 15-247 5.9e-77 254.3 In-house 48-275 (297) alignment 
Range on Protein: 15-247
Range on HMM: 48-275/297.0
ATASYANPNLLKNRYGNIVAYDAGRVKLSQIGD-DPSTDYINASWVDAYKQ-PNGYIASQGPVPNSFLDFWRMVWEQNACTIVMVTHEVEKGRiKCHRYW
 . ..   |  |||| .|..||  ||||. ... |...||||||.|| |.. .. .||.||| |... |||||||||.  .|||.| .||.|| ||..||
ysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfIatqgPlpetvedFwrmvweqgvtvivmLtklvelgr.kcaqyw

PDPTStpptqtlSYGDVTVTHLRAEAHRHFVVRTFLVRCNSEERTVKQFAYTSWPDHGVPLTTAELLGFRNAVNAGTP--NKDVPIVIHCSAGVGRTGTY
|. ..        |||.||| |. | . ...|||. |. |.|.|||..| ||.||||||| ... || | ..|.      .|. |...|||||||||||.
peegg.......tygdftvtllkvehldgytvrtlevtnngesrtvthfqytgwpdhgvppslellleflelvrealaelpkggpvlVHCsaGvgRtGtf

IAIDTLVKQClDMGGMPNVDAVVRDMRLRRNYMVQTE
||..... |. . .| ..|. .|. .| .|...|||.
iaaylmleql.ekeggvdvleavkelreqRpgavqtp
0045450 (Phosphotyrosine protein) phosphatases II 14-247 4.5e-76 251.8 In-house 46-290 (307) alignment 
Range on Protein: 14-247
Range on HMM: 46-290/307.0
PATASYANPNLLKNRYGNIVAYDAGRVKLSQIGDD-PSTDYINASWV--------DAYKQPNGYIASQGPVPNSFLDFWRMVWEQNACTIVMVTHEVEKG
. ....   |  |||| .|..||  ||||| .... ...||||||.|        | |.... .|| ||| |... |||||.|||.  .|||.|..||.|
eysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydlkrkfIatqgPlpetvedFwrmlweqgvtvivmltelvelg

RIKCHRYWPDPtstppTQTLSYGDVTVTHLRAEAHRHFVVRTFLVR---CNSEERTVKQFAYTSWPDHGVPLTTAELLGFRNAVNA--GTPNKDVPIVIH
|.||..||||       ..| ||..||| |. | . ...|||. |     ..|.|||..| ||.||||||| ...||| | ..|..  .. .|. |...|
rekcaqywPde.....geeltygnftvtllseehldgytvrtlevtdldgtgesrtvthfhytgwpdhgvppsfeelldfieevrkaleelpkggpvlVH

CSAGVGRTGTYIAIDTLVKQClDMGGM---PNVDAVVRDMRLRRNYMVQTE
||||||||||.||.... .|  . .|.   .... .|. .| .|  .||..
CsaGvgRtGtfiaaylmlrql.ekegtlldvdlleavkllreqRpgavqnp
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 3-247 8.2e-76 249.8 In-house 27-265 (288) alignment 
Range on Protein: 3-247
Range on HMM: 27-265/288.0
YQDFYDIGRDQPATASYANPNLLKNRYGNIVAYDAGRVKLSQIGDDPSTDYINASWVDAYKQPNGYIASQGPVPNSFLDFWRMVWEQNACTIVMVTHEVE
|.    .....  ||.    |  |||| ||..||  |||| .  . ...||||||..| .|. . |||.|||....  |||..|.|... ||||.|. ||
ynsLaalektksvtagrlavnakknRyrnilpyDekrvklkkleeeagaDYinasyidgekkkkkyiatqgPladtvndfWelvyenktstivmltelve

KGRIKCHRYWPDPTstpptQTLSYGDVTVTHLRAEAHRHFVVRTFLVRCNSEERTVKQFAYTSWPDHGVPLTTAELLGFRNAVNAGTPNKDVPIVIHCSA
.|. ||..||||       .   ||.|||| .  .   .||.|..|.  . .|....|..|..|||||||  .|.||.... |.   ...  ||..||||
ggktkCeeYWPdad.....kpknyGsvtvtlveskeledfvlrklllekkkteleitqyqylaWpdhgvPeskapllellrqvkvanqadtgpiivhCsa

GVGRTGTYIAIDTLVKQCLDmGGMPNVDAVVRDMRLRRNYMVQTE
|||||||.||.|.|...      . .| ..|  .| .|. .|||.
GvGrtgtFialdalidavee.edyiDvagtvaklRkqRallvqtl
DSPc_SM00195 14-247 1.4e-74 246.1 In-house 17-248 (263) alignment 
Range on Protein: 14-247
Range on HMM: 17-248/263.0
PATASYANPNLLKNRYGNIVAYDAGRVKLSQIGDDPSTDYINASWVDAYKQPNGYIASQGPVPNSFLDFWRMVWEQNACTIVMVTHEVEKGRIKCHRYWP
. | .  . |  |||| ||. ||  ||||... .....|||||.... ..... ||| ||| |. . ||||||||..  .|||.| |.|.|..||.||||
etteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlteeeengkekcdrywp

DPTstppTQTLSYGDVTVTHLRAEAHR-HFVVRTFLVRCNS--EERTVKQFAYTSWPDHGVPLTTAELLGFRNAVNAGTPNKDVPIVIHCSAGVGRTGTY
.       ..  .|...|.  . | .. ....||. .. .   |.|.|.|. |..||||||| .| ..| . .||.  . ....|||.|||||||||||.
ees....ggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkkskstssgpivVhCsaGvgRtgtf

IAIDTLVKQcLDMGGMPNVDAVVRDMRLRRNYMVQTE
..||..... |... .......|. .|  |  ||||.
vtidiilsk.leeekkvdifeivkelRkqRpgmvqtl
PTPc_SM00194 14-247 1.4e-74 246.1 In-house 17-248 (263) alignment 
Range on Protein: 14-247
Range on HMM: 17-248/263.0
PATASYANPNLLKNRYGNIVAYDAGRVKLSQIGDDPSTDYINASWVDAYKQPNGYIASQGPVPNSFLDFWRMVWEQNACTIVMVTHEVEKGRIKCHRYWP
. | .  . |  |||| ||. ||  ||||... .....|||||.... ..... ||| ||| |. . ||||||||..  .|||.| |.|.|..||.||||
etteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlteeeengkekcdrywp

DPTstppTQTLSYGDVTVTHLRAEAHR-HFVVRTFLVRCNS--EERTVKQFAYTSWPDHGVPLTTAELLGFRNAVNAGTPNKDVPIVIHCSAGVGRTGTY
.       ..  .|...|.  . | .. ....||. .. .   |.|.|.|. |..||||||| .| ..| . .||.  . ....|||.|||||||||||.
ees....ggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkkskstssgpivVhCsaGvgRtgtf

IAIDTLVKQcLDMGGMPNVDAVVRDMRLRRNYMVQTE
..||..... |... .......|. .|  |  ||||.
vtidiilsk.leeekkvdifeivkelRkqRpgmvqtl
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 17-247 5.9e-74 244.0 In-house 42-269 (319) alignment 
Range on Protein: 17-247
Range on HMM: 42-269/319.0
ASYANPNLLKNRYGNIVAYDAGRVKLSQIGDDPSTDYINASWVDAYKQPNGYIASQGPVPNSFLDFWRMVWEQNACTIVMVTHEVEKGRIKCHRYWPDpt
 .  . |  |||| ||.|||  ||.||.. . ...||||||..|.|.. . .|| |.|. | . ||||||||... ..||.|. |||...|...|||.  
saskeenkkknryqnilaydrtrvvlseldgvegsdyinasfidgyqerekfiatqaPlentiedfWrmvWeeessivvmltklveklkvklkkywpe..

stppTQTLSYGDVTVTHLRAEAHRHFVVRTFLVRCNSEE---RTVKQFAYTSWPDHGVPLTTAELLGFRNAVNAGTP-NKDVPIVIHCSAGVGRTGTYIA
    ..  .|| ..|| .  |   ....| . .. .|.|   |.||.| ||.||||.|| ..  || . . ..  .  ... |||.|||||||||||.|.
....enfeeyGrlivtleeeeeledyiirklklnkkssevetRevkhfqyteWpdhdvPekatslldllkrirksrektqsgPivvhCsaGvGRtGtfiv

IDTLVKQClDMGGMPNVDAVVRDMRLRRNYMVQTE
.|  . .     |. .|  .|. .|. || |||..
ldamlerv.keegvlDvfstvsrlRtqRnimvqrp
0040439 (Phosphotyrosine protein) phosphatases II 17-247 1.9e-73 242.4 In-house 5-232 (249) alignment 
Range on Protein: 17-247
Range on HMM: 5-232/249.0
ASYANPNLLKNRYGNIVAYDAGRVKLSQIGDDPSTDYINASWVDAYKQPNGYIASQGPVPNSFLDFWRMVWEQNACTIVMVTHEVEKGRIKCHRYWPDpt
 ..   |. |||| .|..||  ||||| ... . .||||||..| |.... .|| ||| |... |||||.||..  .|||.|..||.||.||..|||.  
vallpenkdknrypdilpydhsrvklsilpglflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywpl..

stppTQTLSYGDVTVTHLRAEAHRHFVVRTFLVR--CNSEERTVKQFAYTSWPDHGVPLTTAELLGFRNAVNA--GTPNKDVPIVIHCSAGVGRTGTYIA
     ..| |||.||| |. | . ...|||. .    ..|.|||... ||.||||||| ....|| | .||.    . .|. |...|||||||||||.||
....ggsleygdftvtllsvevkddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfia

IDTLVKQCLDMGGmPNVDAVVRDMRLRRNYMVQTE
..... |    .|  ... .|...| .|...||..
aylmleqlekelg.vdleeavkllrsqRpgavqnp
0042113 (Phosphotyrosine protein) phosphatases II 22-247 1.5e-72 239.2 In-house 8-229 (245) alignment 
Range on Protein: 22-247
Range on HMM: 8-229/245.0
PNLLKNRYGNIVAYDAGRVKLSQIGDDPSTDYINASWVDAYKQPNGYIASQGPVPNSFLDFWRMVWEQNACTIVMVTHEVEKGRIKCHRYWPDptstppT
 |  |||| .|..||  ||||| .| |. .||||||.|| |......||.||| |... |||||.||..  ||||.| |.|.||.||..|||.       
enkdknrysdilpydhtrvklspdggdldsdyinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywpl......g

QTLSYGDVTVTHLRAEAHRHFVVRTFLVR--CNSEERTVKQFAYTSWPDHGVPLTTAELLGFRNAVNAGTP-NKDVPIVIHCSAGVGRTGTYIAIDTLVK
..| |||.||| |. | . ...|||. |    ..|.|.| .. |..||||||| ... || | ..|.     ... |...|||||||||||.||..... 
esltygdftvtllseehlddytvrtlevtnlgddesrevihyhylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylmle

QCLDMgGMPNVDAVVRDMRLRRNYMVQTE
|     .  ... .|...| .|  .|||.
qleke.lgvsleeavkelrsqRpgavqtp
subfamily_PTPN9_pd Subfamily PTPN9 16-247 7.9e-72 236.8 In-house 35-276 (297) alignment 
Range on Protein: 16-247
Range on HMM: 35-276/297.0
TASYANPNLLKNRYGNIVAYDAGRVKLSQIGDDPSTDYINASWVDAYKQPNGYIASQGPVPNSFLDFWRMVWEQNACTIVMVTHEVEKGRIKCHRYWPDP
.||  . || |||| ... ||  ||.|... .|. .|||||..|| |||....|| |||... . |||||||||.. .|||.|. ||.||.|| .|||. 
lasklranleknrytdvlcydetrvvlakvdedeasdyinanfvdGykqkkafiatqGplkktvsdfWrmvWeqevlvivmttrvvergrlkcgqyWple

TSTpptqTLSYGDVTVTHLRAEAHRHFVVRTFLVR--CNSEERTVKQFAYTSWPDHGVPLTTAELLGFRNAVNA---------G----TPNKDVPIVIHC
. .    . ..||..|...  | .....||.. ..   ..|.|.|  | ..||||.||| ..|.|| ....|           |     . .. |||.||
ees....saefgdlsvsnveveeeedykvrvleiknvkteesrkvthfqflsWPdyGvPssaaslldvlekvrekqalavkelgdewkghpsgPPivvhc

SAGVGRTGTYIAIDTLVKQcLDMGGMPNVDAVVRDMRLRRNYMVQTE
|||.|||||.|..|  ... |.. |. .|  .|. .| .| ...||.
saGiGrtGtfitldiclsr.leevgtvdvvetvkllrtqrafsiqtp
subfamily_PTPRK_pd Subfamily PTPRK 20-247 4.9e-71 234.1 In-house 40-263 (314) alignment 
Range on Protein: 20-247
Range on HMM: 40-263/314.0
ANPNLLKNRYGNIVAYDAGRVKLSQIGDDPSTDYINASWVDAYKQPNGYIASQGPVPNSFLDFWRMVWEQNACTIVMVTHEVEKGRIKCHRYWPDPTStp
 . |  |||.|.|.|||  ||.| .| .|||.|||||...|.||.|. .|. |||...   ||||.|...|...|||.|. ||.||.|| .|||. |.  
kdenreknrsgdilaydrsrvflitidgdpssdyinaalidsykrpaafivtqgPlqetvkdfWrlvydencasivmltelvevgrvkClkyWPedte..

ptqTlsYGDVTVTHLRAEAHRHFVVRTFLVR----CNSEERTVKQFAYTSWPDHGVPLTTAELLGFRNAVNAGTPNKDVPIVIHCSAGVGRTGTYIAIDT
   .  |||. |. ...|..  .|||.| |.      .| |.|.|| ...||||.||     ||..   |.. ..... .||.||||| |||||.||||.
...v..ygdikvelvetellaelvvrifrveklargqeeirevrqfqflgWpdhdvPvsatgllklvrrvkksqeeeaGrivvhCsaGaGrtGtfiaidi

LVKqCLDMGGMPNVDAVVRDMRLRRNYMVQTE
..   ..  |. .|  .|...| |.  ||.||
vld.mieregvvdvfnavktlrsrkvnmvete
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 14-247 6.5e-71 234.0 In-house 47-276 (298) alignment 
Range on Protein: 14-247
Range on HMM: 47-276/298.0
PATASYANPNLLKNRYGNIVAYDAGRVKLSQIGDDPSTDYINASWVDAYKQPNGYIASQGPVPNSFLDFWRMVWEQNACTIVMVTHEVEKGRIKCHRYWP
  ... .. |  |||| .|.|.|  || |... .|  .||||||...|||. | .||.|.|..... ||||||.|... ||||.|  .|....|.|.|||
ekevarkpenkkkNRyadiialdssRvvLekedadeesdYiNAsflhaykgrnafiatqaPltetvedFWrmvteedigtiVmltnleeldktkyhkywP

DPTSTpptqtlSYGDVTVTHLRAEAHRHFVVRTFLVRC--NSEERTVKQFAYTSWPDHGVPLTTAELLGFRNAVNAGTPN-KDVPIVIHCSAGVGRTGTY
|  ..       ||..||. |. | .  ..||.. |    ...||.|.|. .|||||.||| ..  .|.... |.| . . ...|....|||||||.||.
degke......tygeitvsllskeefadlivrklkvskkkeekerevrqlhftsWpdkgvpenatsvldllrkvrasqqqagnkpvivqCsaGvgRsGtf

IAIDTLVKQClDMGGMPNVDAVVRDMRLRRNYMVQTE
||||... .      .  |  ||. .| .|  .||||
iaidsvlerv.kkeqvvDvfqvvkvlRkkrpgavqte
subfamily_PTPRG_pd Subfamily PTPRG 11-247 1.3e-70 233.2 In-house 35-273 (563) alignment 
Range on Protein: 11-247
Range on HMM: 35-273/563.0
RDQPATASYANPNLLKNRYGNIVAYDAGRVKLSQIGDDPST-DYINASWVDAYKQPNGYIASQGPVPNSFLDFWRMVWEQNACTIVMVTHEVEKGRIKCH
.| .|..| .. |  |||| ||||||  |||||.. .  .. |||||...| |.. . .||.|||... | |||||.||||. .|||.|  ||.|| ||.
kdldaehsqkpenkrKnRylnivaydrsRvklsplpgkkkklDYinAnyidGyqkskafiatqgplkdtfddFWrmiWeqnvaiivmitnlvergrrkcd

RYWPDptstppTQTLSYGDVTVTHLRAEAHRHFVVRTFLVRC-----NS---EERTVKQFAYTSWPDHGVPLTTAELLGFRNAVNAGTPNKDVPIVIHCS
.|||        ... || ..||  . | .    |||. ..      ..   .|..|.|. ||.|||||||  ..  | | .  .| ....  |||.|||
vYWPk......desetygalqvtlieeevlalytvrtlviknlklkkkkqcdteklvrqyhytkWPdhgvPehslpvLifvkkssaankaeaGPivvHcs

AGVGRTGTYIAIDTLVKQcLDMGGMPNVDAVVRDMRLRRNYMVQTE
||||||||||..|||.|| .    . ||  ... .|..||..||||
aGvgrtGtyivldtllkq.iqqenavnvfgflkhiraqRnflvqte
subfamily_PTPN12_pd Subfamily PTPN12 14-247 3.9e-70 231.0 In-house 31-263 (290) alignment 
Range on Protein: 14-247
Range on HMM: 31-263/290.0
PATASYANPNLLKNRYGNIVAYDAGRVKLSQIGDDPSTDYINASWVDAYKQPNGYIASQGPVPNSFLDFWRMVWEQNACTIVMVTHEVEKGRIKCHRYWP
...|. .. |  |||| .|. ||  ||.||.| ...  |||||...   ...  |||.|||.|.   |||||.||.|   .||. .||| |..||.||||
steagekeenvkknrykDilPydksrvelskieeeegsdYinanfikgvegkleyiaaqgPLpktlddfWrmiweknveivvmaCrevelgkkkCerYWp

DPTStpptQTLSYGDVTVTHLRAEAHR-HFVVRTFLVRCNSEERTVKQFAYTSWPDHGVPLTTAELLGFRNAVNAGTPNKDVPIVIHCSAGVGRTGTYIA
. .     ..| .|...||  . .|    |..||. |....|.|.|.|| ||.||||||| .. .|| . ..|.    ..|.|.|.||||||||||| ||
eege....eelefgefevtleeekavdddflirtLkveaqkesrkvyqfhYtaWPDhgvPssaksllelielvrelqesedaPlvvhCsaGvGrtGtiia

IDTlVKQCLDMGGM-P--NVDAVVRDMRLRRNYMVQTE
||  |.. |  . . .  .|  .|...| .|. .|||.
idy.vrellkaekipeeldvfdlvlelrkqraalvqtk
Y_phosphatase Protein-tyrosine phosphatase 23-247 1.2e-69 229.7 Pfam-A 1-223 (235) alignment 
Range on Protein: 23-247
Range on HMM: 1-223/235.0
NLLKNRYGNIVAYDAGRVKLsqIGDDPSTDYINASWVDAYKQPNGYIASQGPVPNSFLDFWRMVWEQNACTIVMVTHEVEKGRIKCHRYWPdptsTPPTQ
|. |||| .|..||  ||||   |.. ..|||||..|. ||... .||.|||..... |||||||...  .|||.|...|||| ||..|||    .   .
nkkknRykdilpydktrvkl..kgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwp....eeeee

TLSYGDVTVTHL-RAE-AHRHFVVRTFLVR--CNS-EERTVKQFAYTSWPDHGVPLTTAELLGFRNAVNAGTPNKDVPIVIHCSAGVGRTGTYIAIDTLV
.|.|||..|.   . . .. ....|.. ..  ... |.|.|||. ||.||||||| .. .|| . ..|.  . .|. |.|.|||||||||||..|.|.|.
sltygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldill

KQCLDMGGmPNVDAVVRDMRLRRNYMVQTE
.|. . .  ..|  .|. .| .|. |||..
eqleaeee.vdvlqivkelRkqRpgmvqsl
Y_phosphatase Protein-tyrosine phosphatase 23-247 1.2e-69 229.7 In-house 1-223 (235) alignment 
Range on Protein: 23-247
Range on HMM: 1-223/235.0
NLLKNRYGNIVAYDAGRVKLsqIGDDPSTDYINASWVDAYKQPNGYIASQGPVPNSFLDFWRMVWEQNACTIVMVTHEVEKGRIKCHRYWPdptsTPPTQ
|. |||| .|..||  ||||   |.. ..|||||..|. ||... .||.|||..... |||||||...  .|||.|...|||| ||..|||    .   .
nkkknRykdilpydktrvkl..kgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwp....eeeee

TLSYGDVTVTHL-RAE-AHRHFVVRTFLVR--CNS-EERTVKQFAYTSWPDHGVPLTTAELLGFRNAVNAGTPNKDVPIVIHCSAGVGRTGTYIAIDTLV
.|.|||..|.   . . .. ....|.. ..  ... |.|.|||. ||.||||||| .. .|| . ..|.  . .|. |.|.|||||||||||..|.|.|.
sltygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldill

KQCLDMGGmPNVDAVVRDMRLRRNYMVQTE
.|. . .  ..|  .|. .| .|. |||..
eqleaeee.vdvlqivkelRkqRpgmvqsl
0045098 (Phosphotyrosine protein) phosphatases II 17-247 1.5e-69 229.7 In-house 27-258 (278) alignment 
Range on Protein: 17-247
Range on HMM: 27-258/278.0
ASYANPNLLKNRYGNIVAYDAGRVKlsqigddpstDYINASWVDAYkqPNGYIASQGPVPNSFLDFWRMVWEQNACTIVMVTHEVEKGRIKCHRYWPDpt
 .    || |||| .|..||  |||          ||||||..| |  |. .|| ||| |. . |||||.||..  .|||.|..||.||.||..|||.  
palylgnldknRykdilpydhsrVk..........dYINAsyidgy..pkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrekcaqywpe..

stppTQTLSYGDVTVTHLRAEAHRHFVVRTFLVR------CNSEERTVKQFAYTSWPDHGVPLTT--AELLGFRNAVNAGTPN-------------KDVP
     ..| |||.||| |  | . ....||.||.       . |.|.|... |..||||||| ..  . .| . . ...   .             .. |
....ggsltygdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsggp

IVIHCSAGVGRTGTYIAIDTLVKQCldmGGMPNVDAVVRDMRLRRNY-MVQTE
...|||||||||||..|.... ...   .|  ... .|. .| .|.. .||..
vlVHCsaGvgRtGtlvaaylmlell...eggvdlleavkelrsqRpglavqnl
subfamily_PTPRA_pd Subfamily PTPRA 21-247 2.1e-69 229.0 In-house 56-281 (330) alignment 
Range on Protein: 21-247
Range on HMM: 56-281/330.0
NPNLLKNRYGNIVAYDAGRVKLSQIGDDPSTDYINASWVDAYKQPNGYIASQGPVPNSFLDFWRMVWEQNACTIVMVTHEVEKGRIKCHRYWPDPTStpp
. |  |||. ||. ||  || ||..   ...||||||..| ||. . .||.|||  ..  |||||.|||...||||.|.  |. . ||..||||  .   
eenkeknrvvnilPydfsrvilsvkeGveesdyinasfidGykekdkfiaaqGPkeetvedfwrmiweqksativmltelkerkeekcaqywPdeGl...

tqtLSYGDVTVTHLRAEAHRHFVVRTFLVR-----C-NSEERTVKQFAYTSWPDHGVPLTTAELLGFRNAVNAGTPNKDVPIVIHCSAGVGRTGTYIAID
   ..||...|.    .   .. || |||.     . . ..| |.|| .||||| ||| ..  .| . ..|..  ...  |||.|||||||||||.|..|
...vtyGnirvevedetvlvdytvrkflvqqlpdatrekksrlvrqfhftswPdvGvPfepiGmlkllkkvkklnqqsagpivvhcsaGvGrtGtfivld

TLVKQcLDMGGMPNVDAVVRDMRLRRNYMVQTE
..... .   .. .|  .|. .||.|  ||||.
avler.vkaerkvdvfefvkrlrlqrpqmvqtd
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 14-247 5.8e-69 227.5 In-house 34-262 (515) alignment 
Range on Protein: 14-247
Range on HMM: 34-262/515.0
PATASYANPNLLKNRYGNIVAYDAGRVKLSQIGDDPSTDYINASWVDAYKQPNGYIASQGPVPNSFLDFWRMVWEQNACTIVMVTHEVEKGRIKCHRYWP
| | .  . |  ||||.||. ||  ||||  | |.|  ||.||| . ...  . ||||||| . |  ||||.|...|  ||.|||.  |  .||| .|||
pqtvaqeeinfkknryknilPydsvrvklevindnPhsdyfnasyipsfdndkayiasqgPnkasvddfWrlvlqenvttiamvtklkegdkikcgkyWP

DptstPPTQTLSYGDVTVTHLRAEAHRHFVVRTFLVRCNSEERTVKQFAYTSWPDHGVPLTTAELLGFRNAVNAGTPNKDVPIVIHCSAGVGRTGTYIAI
|     |.... .| . |  .  ||    . |.. |  ... ||| || .| |||.|||  |  || .  .| | . .   |..||||||||||| .|.|
d....kpgdsvkfGsikvelvsleactggikrkltvlkgddsrtvtqfhfteWPdkGvpkhtssllklikevkadhgqythpliihcsaGvGrtGvvisi

DTLVKQClDMGGMPNVDAVVRDMRLRRNYMVQTE
|  | .    . | .|  .|. .| .| |.|||.
dsvvaha.kttrmvdvfnfvtnirqkrpylvqtq
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 13-247 9.9e-68 223.3 In-house 34-263 (315) alignment 
Range on Protein: 13-247
Range on HMM: 34-263/315.0
QPATASYANPNLLKNRYGNIVAYDAGRVKLSQIGDDPSTDYINASWVDAYKQPNGYIASQGPVPNSFLDFWRMVWEQNACTIVMVTHEVEKGRIKCHRYW
 . ...  . |  ||||.||. .|  ||||  | |.|  |||||| . .... . ||||||| . |  ||||||..... ||||||.  |  .||| .||
yrqrvaretinfkknryknilPldsarvkleviddsPdsdyinasyiksvdddkayiasqgPlkasvddfwrmvlqekvttivmvtkkqegdkikcrqyw

PDPTstppTQTLSYGDVTVTHLRAEAHRHFVVRTFLVRCNSEERTVKQFAYTSWPDHGVPLTTAELLGFRNAVNAGTPNKDVPIVIHCSAGVGRTGTYIA
||      ...  .| . |. |  ||    |.| . .|   | ||| || .| |||.||.  |. || .  .| |   .|. ....||||||||||  |.
Pdrk....adsvefGsikvellsleadtdgvarklvtrkseesrtvtqfqftewPdkGvdkqtssllklikevkadngkkefsllvhcsaGvGrtGvvis

IDTLVKQCLdMGGMPNVDAVVRDMRLRRNYMVQTE
||  |.|    . . .|  .|. .|  | |.||||
idevvaqik.rtrsvdvfnfvknlrakrpylvqte
subfamily_Ptp69D_pd Subfamily Ptp69D 15-245 1.8e-67 222.6 In-house 40-270 (307) alignment 
Range on Protein: 15-245
Range on HMM: 40-270/307.0
ATASYANPNLLKNRYGNIVAYDAGRVKLSQIGDDPSTDYINASWVDAYKQPNGYIASQGPVPNSFLDFWRMVWEQNACTIVMVTHEVEKGRIKCHRYWPD
...|  . |.||||| .|.|.|  ||||..|  . ..||||||.. .||. . .||.|.|| .   |||||..||.  .|||.. . || | ||..|||.
tkvsekkenalknRyedikafDktRvkLkkingkedsdYinasfikgykekkkfiaaqdPveatigDfWRmiaeqevtlivmlsnlteknrkkcakYWpi

PtstpptQTLSYGDVTVTHLRAEAHRHFVVRTFLVRCNS-------EERTVKQFAYTSWPDHGVPLTTAELLGFRNAVNAGTPNKDVPIVIHCSAGVGRT
       ..  |||. |.  . | | ... |.. |  .        ..| | |. ||.|.|  || ..  || . . |.    ..  |||.||||||||.
e......devqygdilvklvseekhsdyiiReldvskkkeesgevedsrkvvqyhytgWkDskvPevargllklieqvrelyklnrsPivvhCsaGvgrs

GTYIAIDTLVKQCLDMgGMPNVDAVVRDMRLRRNYMVQ
|...|.| |..|.       .. ..|.|.| .|| .||
gifvaldsllqqlkae.dkvdifetvkdLrsqRnllvq
0037934 (Phosphotyrosine protein) phosphatases II 22-247 2.5e-67 222.2 In-house 9-228 (243) alignment 
Range on Protein: 22-247
Range on HMM: 9-228/243.0
PNLLKNRYGNIVAYDAGRVKLsqigDDpsTDYINASWVDAYkqPnGYIASQGPVPNSFLD----FWRMVWEQNACTIVMVTHEVEKGRIKCHRYWPdpts
 || |||| .|..|| .||||    ..  .|||||.... .  | ..||.||| |... |    ||||.||..  .|||.|..||.||.||..|||    
enlsknrysdilpydhsrvkl....eg..sdyinanliyvt..p.rliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywp....

tpptQTLSYGDVTVTHLRAEAHRHFVVRTFLVRC---NSEERTVKQFAYTSWPDHGVPLTTAELLGFRNAVNAG--------TPNKDVPIVIHCSAGVGR
    ..  |||.||| |  | . ...|||.|...   . ..|.| .. |..||||||| ... || | ..|..         . ... |...||||||||
....gevtygdftvtllseehlddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgR

TGTYIAIDTLVKQCldmgGmPNVDAVVRDMRLRRNY-MVQTE
|||.||.... ...    |  ... .|...| .|.. .|||.
tGtliaaylmllll....g.vdleeavkllreqRpgkavqtp
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 22-247 3.8e-67 221.1 In-house 8-228 (250) alignment 
Range on Protein: 22-247
Range on HMM: 8-228/250.0
PNLLKNRYGNIVAYDAGRVKLSQIGDDPSTDYINASWVDAYKQPNGYIASQGPVPNSFLDFWRMVWEQNACTIVMVTHEVEKGRIkCHRYWPDPtstppt
 |. |||| .|.|.|  || | .   |  .||||||....|.. . .||.|||..... ||||||.|... ||||.|  .|...  .|.|||        
qnkeknryadiialdssrvvLekekgdkesdyinasflhgyderkafiatqgPlqatiedfWrmvleeksgtivmLtnLkesekt.yhqywPve......

QTLSYGDVTVTHLRAEAHRHFVVRTFLVRCNSE--ERTVKQFAYTSWPDHGVPLTTAELLGFRNAVNAGTPN-KDVPIVIHCSAGVGRTGTYIAIDTLVK
..  ||||||. |  | .  ...|.. .  ...  ||.|.|. ...||| ||| ..   |.... |.|  .. .. |....|||||||.|..||||....
kaekyGdvtvsllskeefadytkrklklskakkaderivrqlhfvvWPdkgvPevatavLellkkvqasqqqagnaPvivqCsaGvgrsGafiaidavle

QcLDMGGMPNVDAVVRDMRLRRNYMVQTE
. |    . .|  |.. .|  |  .|...
r.lkkekvvdvfkvikvlrkdrphavesl
subfamily_PTPN6_pd Subfamily PTPN6 22-249 4.2e-67 221.3 In-house 53-285 (306) alignment 
Range on Protein: 22-249
Range on HMM: 53-285/306.0
PNLLKNRYGNIVAYDAGRVKLSqIGDDPSTDYINASWVD--AYKQPNGYIASQGPVPNSFLDFWRMVWEQNACTIVMVTHEVEKGRIKCHRYWPDPTSTP
 |  |||| ||. .|  ||.|.   . | .|||||. ..  . .. . |||.|| ...   |||||||..|.  |||.|.|||.|. || ||||| ....
enkeknryknilPfDhtrvilk.epsvpgsdyinanyikkevkgsdksyiatqgclettvsdFWrmvwqensrvivmttkevErgkekCarYWPdeeeke

ptqtLsYGDVTVTHLRAEAHRHFVVRTFLVR---CNSEERTVKQFAYTSWPDHGVPLTTAELLGFRNAVNAGTPNKD----VPIVIHCSAGVGRTGTYIA
      ||...||... ........|...|     ..|||.| |. ..||||||||  .  .| | . ||. . .       |||.|||||.|||||.| 
....e.yGkisvtnvseksladYilRelsvskkkkkkeerevfqyhfksWPdhgvpkdpgavLdfledvnrkqeeleeaeagpivvhCsaGiGRtGtfiv

IDTLVKQCLDMGGMPNV--DAVVRDMRLRRNYMVQTEVC
||.|.|.    |   ..    .|. .|  |. .|||| .
iDillkliekkgldadidiqklvksvreqrsglvqteqq
subfamily_PTPN3_pd Subfamily PTPN3 3-247 2.1e-66 218.7 In-house 21-261 (280) alignment 
Range on Protein: 3-247
Range on HMM: 21-261/280.0
YQDFYDIGRDQPATASYANPNLLKNRYGNIVAYDAGRVKLSQigddPSTDYINASWVDA----YKQPNGYIASQGPVPNSFLDFWRMVWEQNACTIVMVT
.. .|   ..   .|.    || |||| .|..||| ||||..     .||||||..|.      .. | |||.|||....  |||.|||||.. .|||.|
feqlyrkkpglaisaarkpenlsknryrdilpydatrvklke....setdyinanyvnmeipstglvnryiatqGPlaktatdfWqmvweqksslivmlt

HEVEKGRIKCHRYWPDptstpPTQTLSYGDVTVTHLRAEAHRHFVVRTFLVRCNS--EERTVKQFAYTSWPDHGVPLTTAELLGFRNAVNAGTPNKDVPI
  ||.||.|||.|||.     ....|.||. .|.  . .... .|.| .... ..  |||.. |. |..|||||||  .|..| | . |..    |. |.
tlverGrvkChqyWPe.....tedeleygefsvkcekedetksyvlrelvlkdketkeerkilqlqylaWpdhgvPddsadflefvervrklrsgkeePv

VIHCSAGVGRTGTYIAIDTLVKqCLDMGGMPNVDAVVRDMRLRRNYMVQTE
|.|||||.|||| .|...| .   ...    .. ..|| || .|  .|||.
vvhCsaGigrtGvlilletala.lieaaepvypldivrtmrdqramlvqta
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 14-246 7.8e-66 217.1 In-house 40-264 (315) alignment 
Range on Protein: 14-246
Range on HMM: 40-264/315.0
PATASYANPNLLKNRYGNIVAYDAGRVKLSQIGDDPSTDYINASWVDAYKQPNGYIASQGPVPNSFLDFWRMVWEQNACTIVMVTHEVEKGRIKCHRYWP
|   .    |  |||| ||.|||  ||.|  .  || .||.||...| |.... |||.||| ..|  ||||.|.|..  .|||.|  ||. . |. .|||
pldvakkienkqknryiniiaydksrvqlpllendphsdyvnanfidGynkkrryiaaqgpnvasvkdfwrlvfeedigkivmltnlvegekrkaekywp

DPtstpptqTLSYGDVTVTHLRAEAHRHFVVRTFLVRCNSEERTVKQFAYTSWPDHGVPLTTAELLGFRNAVNAGTPNKDVPIVIHCSAGVGRTGTYIAI
|         . || .|||.   | . .. |||. |  ... |.| |. |||||| |||  |  |. .   |.    |.  .||.|||||||||||.|..
dk.......kviyGkitvtrkseevnteytvrtlsvvfgdnirevvqlhytswpdmgvpkytiplmnlirtvkqhhtnsvgaivvhcsaGvGrtGtfitl

DTLVKQcLDMGGMPNVDAVVRDMRLRRNYMVQT
|....| ...  . .|  ... .|  |  |||.
davldq.aeaenaidvynfitgvrqnrikmvqv
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 3-246 4.2e-64 211.6 In-house 28-268 (305) alignment 
Range on Protein: 3-246
Range on HMM: 28-268/305.0
YQDFYDIgrDQPATASYANPNLLKNRYGNIVAYDAGRVKLSQIGDDPSTDYINASWVDAYKQPNGYIASQGPVPNSFLDFWRMVWEQNACTIVMVTHEVE
|. .|.   ...      . |  |||. .|. .|  |..|..  ... .||||||.||.||. . ||..|||..|   ||||...|    ||||.|. ||
ykslyee..eesidvgkkeankaknrlkeitlldddriiltekeslddsdyinasyvdgykrkkkyivaqgPlkntvadfWrliveekvstivmltklve

KGRIKCHRYWPDPTstppTQTLSYGDVTVTHLRAEAHRHFVVRTFLVRC---NSEERTVKQFAYTSWPDHGVPLTTAELLGFRNAVNA-GTPNKDVPIVI
 |. ||..|||. .    |..  .|...|.    ..   .. | . .     ..|.||| |.  |.||||||| ... || . . |.     .|.||...
ggkdkCrqYWpesk....tekkefgefsvelksektasdyieRklkisiededkesrtvlqyqltdWPdhGvpqfatsllslikrvqkdqkkdkgvpllV

HCSAGVGRTGTYIAIDTLVKQCLDmGGMPNVDAVVRDMRLRRNYMVQT
||||||||||..||.|  . ..    .. .|  |.. .| .| .||||
hCsagvgRtGvfiavdialerlkk.EevvdvfevlkqlRskrmkmvqt
subfamily_PTPN13_pd Subfamily PTPN13 19-247 3.6e-63 208.4 In-house 33-255 (273) alignment 
Range on Protein: 19-247
Range on HMM: 33-255/273.0
YANPNLLKNRYGNIVAYDAGRVKLSQIGDdpstdYINASWVDAY--KQPNGYIASQGPVPNSFLDFWRMVWEQNACTIVMVTHEVEKGRIKCHRYWPDPT
  . |  |||| |.. ||. ||||.. |      |||||.. .   |.   |||.|||.|..  |||.|||||.|  |.|||.|.|||..|||||||. .
kkkenkdknryrnvlPydetrvklgdegg.....yinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweqkaeviamvtlekekgkvkchrywPesk

STPptqTLSYGDVTVTHLRAEAHRHFVVRTFLVRCN--SEERTVKQFAYTSWPDHGVPLTTAELLGFRNAVNAGTPnKDVPIVIHCSAGVGRTGTYIAID
. .   .  .. ..|. |. . .  ||||.. |. .  .| | | .. ...||||||| ..|||| |   |.     .  |||.|||||.||.||.|.||
nkk...lkvsnrlevellkvqkldgfvvralavkdsesgesrevahlnfvkwPdhgvPssaaellqfvaevrrlqt.dagPivvhcsaGiGrsGtlitid

TLVkQCLDMGGMPNVDAVVRDMRLRRNYMVQTE
... . ..     .|  .||..| .|. .|||.
vvl.glierdkefdvkeivrklreqrqgvvqtk
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 13-247 1.2e-60 200.2 In-house 41-270 (297) alignment 
Range on Protein: 13-247
Range on HMM: 41-270/297.0
QPATASYANPNLLKNRYGNIVAYDAGRVKLSQIGDDPSTDYINASWVDAYKQpnGYIASQGPVPNSFLDFWRMVWEQNACTIVMVTHEVEKGRiKCHRYW
||.| .  . |. |.|| ||. ||  ||||  ..|||. ||.|||.| ..|.   .|..| | ...  |||.||..... ||||.... |. . || |||
qpqtvaekkvnfeksRYkniLPydssRvkLaivnddpdsDyvnasfvkgnkh..rlittqmPmkatvadfWamvldeqvstivmlnddnerdk.kcaryW

PDPTSTPptqtlsYGDVTVTHLRAEAHRHFVVRTFLVRCNS--EERTVKQFAYTSWPDHGVPL--TTAELLGFRNAVNAGTPNKDV-PIVIHCSAGVGRT
.| ..|.      .|||.|. |  .  . |. |.. |. ..   .| |||. ...|||. |.   ... || . . |.    ..   |...||.||||||
sdkgvtt......fGdvsvvllsvsereGfikrelevtkgkakarrvvkqyqfveWPdkaverkdsassllklisevrkdfsqnaegPllvhclaGvGrt

GTYIAIDTLVKQCLDMGGMpNVDAVVRDMRLRRNYMVQTE
| ...||  | .  .   . ..  .|. .|  | |.|||.
gvlltidsvvaeakrekev.difglvkklrqerpylvqtk
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 18-246 1.5e-60 200.2 In-house 56-276 (319) alignment 
Range on Protein: 18-246
Range on HMM: 56-276/319.0
SYANPNLLKNRYGNIVAYDAGRVKLSQIGDDPSTDYINASWVDAYKQPNGYIASQGPVPNSFLDFWRMVWEQNACTIVMVThevekgRIKCHRYWPDPTS
.  ..|  |||..||.|.|  .||| ..     .||||||.|. |.... |||.||| .|.  |||||.||.|..|||..|      . || .|||  . 
anldqnkdknriinilafdknvvklerliGeefsdyinasfvtGyqrkdkyiaaqGPldntladfWrmiweyncstivllt......kdkcsqywplkiv

tpptQTLSYGDVTVTHLRAEAHrhFVVRTFLVRC---NSEERTVKQFAYTSWPDHGVPLTTAELLGFRNAVNAGT--PNKDVPIVIHCSAGVGRTGTYIA
    ..   ..| |. .   |   .||| . .     . . | ..|| .  |||.|||  ...|. . . |.  |   |.  .||.||||||||||.||.
....ikeerfkvkvdsveetae..yvvrdielsedgkekdirkitqfhflGwpdvGvpdypsdlmrlvkkvrhltskenhranivvhcsaGvGrtGvyiv

IDTLVKQcLDMGGMPNVDAVVRDMRLRRNYMVQT
.|.|... ..   . .|  .|||.| .|| .|| 
ldvlldr.mkeekqvdvynfvrdlrqqrntlvqd
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 26-247 2.6e-60 198.7 In-house 23-250 (270) alignment 
Range on Protein: 26-247
Range on HMM: 23-250/270.0
KNRYGNIVAYDAGRVKLSQIGDDPSTDYINASWVD-AYKQPNGYIASQGPVPNSFLDFWRMVWEQNACTIVMVTHEVEKGRIKCHRYWPDptSTPPTQTL
 ||| .|.   | ||.|... .|. | |||| .|  . .... |||..||.|..  .||||.||... .|||.|. .|||| || ||||   ..  . .|
lnRyadiLPsPatRvrleeleedsataYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkgrkkCerYWpa..epkekvkl

SYGDVTVTHLRAEAHRHFVVRTFLVRCNSEERTVKQFAYTSWPDHGVPLTTA------ELLGFRNAVNAG--TPNKDVPIVIHCSAGVGRTGTYIAIDTL
..|...|. |  | .. ....   .. ..||| .  | |..||||||| ..       .||   .|| .     .|  |...||||||||||| ||.|. 
edgkikvlalseekeegyiltrlrleekgeerrlvHfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkaePllvHcsaGvgRtGtlialDia

VkQCLDMGGMPNVDAVVRDMRLRRNYMVQTE
| ..|.. .  .| |.....|  |  .||. 
v.rlLeetkkvdvlaiieelRkdRmalvqhp
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 18-246 5.7e-60 198.2 In-house 20-240 (284) alignment 
Range on Protein: 18-246
Range on HMM: 20-240/284.0
SYANPNLLKNRYGNIVAYDAGRVKLSQIGDDPSTDYINASWVDAYKQPNGYIASQGPVPNSFLDFWRMVWEQNACTIVMVThevekgRIKCHRYWPDPTS
.  ..|  |||.|.|.|.|  .||| ..     .||||||..  |.... |||.||| .|.  |||||.||.|..|||..|      . || .|||  . 
anldqnkdknrighilafdknvvklerliGeefsdyinasfitGyqrkdkyiatqGPldntladfWrmiweyncstivllt......kdkcsqywplkiv

tpptQTLSYGDVTVTHLRAEAHrhFVVRTFLVRC---NSEERTVKQFAYTSWPDHGVPLTTAELLGFRNAVNAGT--PNKDVPIVIHCSAGVGRTGTYIA
    ..   ..| |. .   .   .||| . .     . . |...|| .  |||.|||  ...|. . . |.  |   |.  .||.||||||||||.||.
....ikeerfkvkvdsveesee..yvvrdielsedgkekdirkirqfhflgwpdvgvpdypsdlmrlvkkvrhltskenhranivvhcsagvgrtgvyiv

IDTLVKQcLDMGGMPNVDAVVRDMRLRRNYMVQT
.|.|... ..   . .|  .|||.| .|| .|| 
ldvlldr.mkeekqvdvynfvrdlrqqrntlvqd
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 10-251 3.1e-59 195.2 In-house 33-273 (290) alignment 
Range on Protein: 10-251
Range on HMM: 33-273/290.0
GRDQPATASYANPNLLKNRYGNIVAYDAGRVKLSQIGDD--PSTDYINASWVDAYKQPNGYIASQGPVPNSFLDFWRMVWEQNACTIVMVTHEVEKGRIK
 ... .|   .. | |.||. ||| ||  |. | .|...   . .||||.... ||. . ||| ||||.|   |||...|... . |||.|...|.|. |
esehtvtvgltssnkllnRfanivvyddnritLrpisghkDCtneyinAcyikgykekkqyiatqgpvsntlvdFWkliwqekvtiivmltniieegkvk

CHRYWPDPtstpPTQTlsYGDVTVTHLRAEAHRHFVVRTFLVRCNSE---ERTVKQFAYTSWPDHG-VPLTTAELLGFRNAVNAGTPNKDVPIVIHCSAG
|. ||||     .|..  || .... |  |.. ... |.. |. ...   ...|.|.  |.|...| |. ... || ... ..    . . .||.|||..
CqqYWpds....dtka..ygefsikllneetlneyierklevknknsagakqsvtqyqitnwdstgkvtnpqtillvieemyktqrkrgntsivvHCSdt

VGRTGTYIAIDTLVKQCLDMGGMpNVDAVVRDMRLRRNYMVQTEVCIG
|||.....|..| ...|   |.. .| .|.. .|  .  .|||.... 
vgrsavfcaaattinkcktegvi.dvfqvlksqRiqkpgsvqtvqqyq
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 4-247 3.7e-58 191.8 In-house 9-254 (274) alignment 
Range on Protein: 4-247
Range on HMM: 9-254/274.0
QDFYDIGRDQPATASYANPNLLKNRYGNIVAYDAGRVKL-SQIGDDPSTDYINASWVDAYK-QPNGYIASQGPVPNSFLDFWRMVWEQNACTIVMVTHEV
..|...  . .        .  |||| .|.  .  || | |. ..|. ..|||| ..  |. . . |.| |||.||   |||||......  |||.|.  
keflelPlnfdqeeldvfgsqtknryktilPnensrvllesessededssyinanyikGydeeskayvatqGPlpntvadfWrmiyqeevqvivmltklk

EKGRIKCHRYWPDPTSTPPTQtlSYGDVTVTHLRAEAHRHFVVRTFLVRCNSEERTVKQFAYTSWPDHGVPLTTAELLGFRNAVNAGTPNKDV---PIVI
|. . ||..|.|| ...  ..   |||| ..   .  . .. ||.....  ..||.|| . ||.|||| .|  . .|| . . |.    ...    |.|.
eaneqkCavyfPdaedyeise..rygdveikvekiverndysvrklvlkylerersvkhywytdWPdhksPddantlldlvleveesreeenaklapvvv

HCSAGVGRTGTYIAIDTLVKQcLDMGGMPNVDAVVRDMRLRRNYMVQTE
|||||.|||| .|||.  |.| |.  .. .|  .| ..|| |  ||||.
hCsaGiGrtGcfiaisiavrq.lreeivvdvlkivcnlrldrGGmvqts
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 12-247 3.3e-57 188.7 In-house 36-264 (287) alignment 
Range on Protein: 12-247
Range on HMM: 36-264/287.0
DQPATASYANPNLLKNRYGNIVAYDAGRVKLSqigdDPSTDYINASWVDAYKQPNGYIASQGPVPNSFLDFWRMVWEQNACTIVMVTHEVEKGRIKCHRY
..  | . |. |  |||. .|. .|  || |     .   |||||...|.||. . .|....|. |   .||......|  .|||...| |. . .|..|
edevthniasqnkdknRltqilvpdnyrvllk....gehpdyinavfidgykekkafiiaesPmfntarnfWkliddrnvtaivmlcqekendeevcyqy

WPDptstppTQTLSYGDVTVTHLRAEAHRHFVVRTFLVRCNS---EERTVKQFAYTSWPDHG-VPLTTAELLGFRNAVNAGTPNKDVPIVIHCSAGVGRT
||.      ......|. ... |  | . ....|.. |. ..   ....|||. .|.|...| |.   . || . . . .   . . .||.|||..|||.
Wpe......eksvvlGeyniellneevnagyierklevknknkagdkqqvkqyqitnWdstgkvtepqtillvieemyktqrkrgntsivvhCsdtvGrs

GTYIAIDTLVKQCLDMGGMpNVDAVVRDMRLRRNYMVQTE
....|..| ...|   |.. .|  |.. .| ..  .||| 
amfcaaattinkckteGvi.Dvfqvlksqriqkpgsvqtv
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 23-247 5.8e-57 187.6 In-house 8-227 (239) alignment 
Range on Protein: 23-247
Range on HMM: 8-227/239.0
NLLKNRYGNIVAYDAGRVKLSQIGDDPSTDYINASWVDAYK-QPNGYIASQGPVPNSFLDFWRMVWEQNACTIVMVTHEVEKGRIKCHRYWPDPTStppt
|  |||| |||.||  || | .. .|| .||||||..  |   |. |||.|| |  |  |||||.|..  | |||.|  .|  . |||.|||| ||    
nkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdsts....

qtlSYGDVTVTHLRAEAHRHFVVRTFLVR--CNSEERTVKQFAYTSWPDHGVPLTTAELLGFRNAVNAGTPNKDVPIVIHCSAGVGRTGTYIAIDTLVKQ
    | .. ||  ..|    ...|||..    ..||| | |. .| |||.|||  .. .||.|  .   .     | ||||||||||||... ||....|
...kycnlrvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcsagvgrtgaflvidamlrq

CLDMGGMpNVDAVVRDMRLRRNYMVQTE
.     . ..   |. .|  | .|||| 
akkqktv.difnyvkairedrphmvqts
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 23-247 6.3e-57 187.5 In-house 7-226 (239) alignment 
Range on Protein: 23-247
Range on HMM: 7-226/239.0
NLLKNRYGNIVAYDAGRVKLSQIGDDPSTDYINASWVDAYK-QPNGYIASQGPVPNSFLDFWRMVWEQNACTIVMVTHEVEKGRIKCHRYWPDPTStppt
|  |||| |||.||  || | .. .|| .||||||..  |   |. |||.|| |  |  |||||.|..  | |||.|  .|  . |||.|||| ||    
nkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdsts....

qtlSYGDVTVTHLRAEAHRHFVVRTFLVR--CNSEERTVKQFAYTSWPDHGVPLTTAELLGFRNAVNAGTPNKDVPIVIHCSAGVGRTGTYIAIDTLVKQ
    | .. ||  ..|    ...|||..    ..||| | |. .| |||.|||  .. .||.|  .   .     | ||||||||||||... ||....|
...kycnlrvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcsagvgrtgaflvidamlrq

CLDMGGMpNVDAVVRDMRLRRNYMVQTE
.     . ..   |. .|  | .|||| 
akkqktv.difnyvkairedrphmvqts
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 23-247 7.9e-57 187.2 In-house 3-225 (237) alignment 
Range on Protein: 23-247
Range on HMM: 3-225/237.0
NLLKNRYGNIVAYDAGRVKLSQIGDDpsTDYINASWVDAYK-QPNGYIASQGPVPNSFLDFWRMVWEQNACTIVMVTHEVEKGRIKCHRYWPDpTstppT
| .|||||||||||  || |   | .  .|||||.... .   |. |||.|||. .|  |||.|||...   |||.|  .|. ..|||.|||. |     
nkiknrygnivaydhsrvvlkgagsg..sdyinatylkgfdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywps.t....d

QTLSYGDVTVTHLRAEAHRHFVVRTFLVRCNS---EERTVKQFAYTSWPDHGVPLTTAELLGFRNAVNAGTPN--KDVPIVIHCSAGVGRTGTYIAIDTL
|  .|| .||.  . |.   . ||..|.  .    | | ..|. .|||||.|||  || || ||  .   .|   .  | .||||||||||| .. ||..
qpaaygvltvslkkkeefsdytvrslllskrltlkevrlihqyqftswpdrgvpqqtaallrfrkniinrsphvsesgpwiihcsagvgrtgiflvidam

VKQCLDMGgMPNVDAVVRDMRLRRNYMVQTE
..|. .   . ..   |  .   | |..||.
lrqakekk.vvdiynyvysieedrpyiiqtk
subfamily_PTPN23_pd Subfamily PTPN23 18-248 3.6e-55 181.8 In-house 38-267 (288) alignment 
Range on Protein: 18-248
Range on HMM: 38-267/288.0
SYANPNLLKNRYGNIVAYDAGRVKLSqigdDPSTDYINASWVDAYK-QPNGYIASQGPVPNSFLDFWRMVWEQNACTIVMVTHEVEKGRIKCHRYWPDPT
. |. .  |||. .|. ||  ||||     .   ||||||.|     .   .||.|.| ...  |||.||.|| . .|||.... |.|. |..||||  .
aiaklyseknrsrdilPyDhnRvklr....gskDDYinAsfvkdlspgcPdfiatqaPlqstlnDFWlmvyeqkssviVmllskeelgkpkvdrYwPedk

stppTQTLSYGDVTVTHLRAEAHRHFVVRTFLVRCN--SEERTVKQFAYTSWPDHGVPLTTAELLGFRNAVNA----GTPNKDVPIVIHCSAGVGRTGTY
     .| ..||..||  . .   ..| |.. .. .  .. ..|.   .||||..||| .  .|| | ..|..       . ..|.|.||||||||||..
....getvkfgdlsvtlksvretethvervlkletldadavksvshlqltsWpelGvPasPetllqfldevesayeavqrksktPlvvhCsaGvgRtgvf

IAIDTLVKQCLDMGGMPNVDAVVRDMRLRRNYMVQTEV
  . . |..     |....  ||. .|  | .|||.. 
alvyaavrelekgnglldiiqvvsrlreqRrfmvqeke
subfamily_PTPN1_pd Subfamily PTPN1 10-247 1.1e-54 180.1 In-house 19-257 (290) alignment 
Range on Protein: 10-247
Range on HMM: 19-257/290.0
GRDQPATASYANPNLLKNRYGNIVAYDAGRVKLSQIGDdpstDYINASWVDAYKQPNGYIASQGPVPNSFLDFWRMVWEQNACTIVMVTHEVEKGRIKCH
 .| |....  . |  .||| ..  ||  |.|| .       |||||| |.. .    || .|||.||    ||.|||||.. ..||. . |||..|||.
asdfptreaklpenrnlnryrdvspydhsrikleradn....dyinaslveleeakrsyiltqGPlpntvdhfWqmvWeqkskavvmlnkvvekeqikca

RYWPDPTStppTQTLSYG--DVTVTHLRAEAHRHFVVRTFLVRC--NSEERTVKQFAYTSWPDHGVPLTTAELLGFRNAV-NAGTPNKDV-PIVIHCSAG
.|||   .   ...| .    ..|. .. | .....||.. .      | |.. .| ||.||| ||| . | .| |   | ..|. ..|| | |||||||
qywPqgee...ekellledtklkvkliseerksyytvrllelenlktqetreilhfhyttwpdfgvpespaaflkflfkvresGslssdvGpavihcsaG

VGRTGTYIAIDTLVKQCLDMGG--MPNVDAVVRDMRLRRNYMVQTE
.||.||.. .||.. .  . .     ..  |. ..|  |  ..|| 
iGrsGtfclvdtclvliekkddlssvdikkvllelrkyrlGliqta
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 23-248 5e-54 178.0 In-house 38-264 (287) alignment 
Range on Protein: 23-248
Range on HMM: 38-264/287.0
NLLKNRYGNIVAYDAGRVKLSQIGDDpSTDYINASWVDAYKQPNGYIASQGPVPNSFLDFWRMVWEQNACTIVMVTHEVEKGRIKCHRYWPDPtSTPptq
.  ||||.... .|  || ||. |.   .||||| .| .|.. . .||.|||.. .  ||||.|.|.........|.|||..| ||..|||..   |   
avkknryadvlPiddtrvllsaegel.GsdyinanyvasytddeafiaaqgPiaatvrdfwravletrsasvitmtreveearlkcykywPer.evP...

tLSYGDVTVTHLRAEA-HRHFVVRTF-LVRCNSEE-RTVKQFAYTSWPDHGVPLTTAELLGFRNAV-----NAGTPNKDVPIVIHCSAGVGRTGTYIAID
 .  |  .|. |  .  . .. ||.. |.  ...| | |||. . ||||.... |.  |. |   |      |   ..  |.|.|...|.||.|...|. 
.mrvGGysvvlldydikePeygvralrlidletrearvvkqldllswPdkvlaPtavglirfvldvkqhielardasevGPlvvhddvGiGrsGillatl

TLVKQCLDMGGMpNVDAVVRDMRLRRNYMVQTEV
.||.. .|.| . .| |||  .| .|. .||. |
vlvsrledlGrv.dvaavvirlreyraalvqavv
subfamily_PTPRN_pd Subfamily PTPRN 17-247 1.3e-52 173.3 In-house 50-278 (297) alignment 
Range on Protein: 17-247
Range on HMM: 50-278/297.0
ASYANPNLLKNRYGNIVAYDAGRVKLSQIGDDPSTDYINASWV-DAYKQPNGYIASQGPVPNSFLDFWRMVWEQNACTIVMVTHEVEKGRIKCHRYWPDP
.. |. |. |||. ....||  ||||..  .. ..|||||| . |   .   |||.|||....  |||.||||| .. ||..|.  |.|  .|.||||| 
vakaeknvkknrskavlpydhsrvklkeeasaeksdyinasaildhdprapayiatqgplastvadfwqmvweqGvvvivnltrleeegvkqckrywpde

TSTppTQTLSYGDVTVTHLRAEahrHFVVRTFLVRC--NSEERTVKQFAYTSWPDHGVPLTTAELLGFRNAVNAGTPNKDVPIVIHCSAGVGRTGTYIAI
 |   .  .   ..   |. ..    ..||.| ..   .|| ||| || . |||..||| ..  || ||  ||     .  |||.|||.|.||||.||.|
Gse..vyhiyevhlvsehiwcd...dylvrsfylknlqtsetrtvtqfhflswpeegvPasaksllefrrkvnksyrGrscpivvhcsdGaGrtGvyili

DTLVKQCLDMGGMPNVDAVVRDMRLRRNYMVQTE
| .... |      .. | .  .| .|. .|.|.
dlvlnrllkGvkeidiaatlehlrdqrpglvktk
subfamily_PTPN14_pd Subfamily PTPN14 15-246 3.5e-52 172.3 In-house 41-281 (300) alignment 
Range on Protein: 15-246
Range on HMM: 41-281/300.0
ATASYANPNLLKNRYGNIVAYDAGRVKLSQIGDDpSTDYINASWVDAY--KQPNGYIASQGPVPNSFLDFWRMVWEQNACTIVMVTHEVEKGRIKCHRYW
 ...  . |  |||. ... |.  ||.||   .. ||.||||| . .    .   ||..|||...   |||.|||||.   |||.|.| |.|. |...|.
lstaklpenaeknrfkdvlPyednrvelsptken.stgyinassikvsvggkersyivaqgPleltvqdfWqmvWeqgvqlivmlteeeedgkeksfkyf

PDPTStpPTQTLSYGDVTVTHLRAEAHRHFVVRTFLVR--CNSEERTVKQFAYTSWPDHGVPLTTAELLGFRNAVNA-------GT--PNKDVPIVIHCS
|. .|    .|. .|   ||    |    .. ... ..    .|||||  . || |||||||    . | . . |..        .   ... |...|||
Pkles..kkktvefgkfkvttkfsedsdsvittglklkhlpskeertvwhlqytDWpdhgvPeDvkgflsyLeevqsvrrktnseveskeskPPvlvhCs

AGVGRTGTYIAIDTLVkQCLDMGGMPNVDAVVRDMRLRRNYMVQT
|||||||  |  | |. ..|. .   ... |.. .| .| ..|||
aGvGrtGvlilsdlli.atlehneeidikkvlarLreqrmllvqt
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 13-247 7.7e-52 171.0 In-house 35-222 (392) alignment 
Range on Protein: 13-247
Range on HMM: 35-222/392.0
QPATASYANPNLLKNRYGNIVAYDAGRVKLSQIGDDPSTDYINASWVDAYKQPNGYIASQGPVPNSFLDFWRMVWEQNACTIVMVTHEVEKGrikchryw
 | |..  . || ||||.||. ||. ||||  | | | .||.|||....... . ||||||| . |. ||||||...|..||.|||.  |          
ypqtvaqkeinlkknryknilpydsarvkleviddipdsdylnasyipsfdnekayiasqgpnaaslddfwrmvfqenvttiamvtklkegd........

pdptstpptqtlsygdvtvthlraeahrhfvvrtflvrCNSEERTVKQFAYTSWPDHGVPLTTAELLGFRNAVNAGTPNKDVPIVIHCSAGVGRTGTYIA
                                         . ||| || .| |||..||  |. || | . |.|   .   |..|||||||||||  |.
......................................kgddartvaqfhftewPdkdvpkhtssllkfikevkadfGqythpliihcsagvgrtgvvis

IDTLVKQClDMGGMPNVDAVVRDMRLRRNYMVQTE
||..| ..     | .|  .| ..| .| |||||.
idsvvaha.kktrmvdvfnfvtnirrkrpymvqtk
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 16-246 1.8e-51 170.2 In-house 41-273 (325) alignment 
Range on Protein: 16-246
Range on HMM: 41-273/325.0
TASYANPNLLKNRYGNIVAYDAGRVKLSQIGDDPSTDYINASWVDAYKQPNGYIASQGPVPNSFLDFWRMV--WEqnaCTIVMVTHEVEKGRIKCHRYWP
...    |  |||. |.||.|  || |   .||||.||||||..  .|. . ..|.| | ...  |.||.|  |.   |..|.|. |...|  .|  |||
kvamkpenkaknrfknvvaldksrvvletkkddpssdyinasylrddkkkdvflaaqaPltatindlWrlvldWr...csvvvvlneldlgkdrcavywp

DPTStpptQTLSYGDVTVTHLRAEAHRHFVVRTFLVRCNSEE--RTVKQFAYTSWPDHGVPLTTAELLGFRNAVNAGT------PNKDVPIVIHCSAGVG
.  .    ..  .| . |    .|    .| | . |.  ..   |.|||| . ||.| ||.   | |. . . |.|         .   ||..|||||||
kemg....ksktfGglevklrtieeisdyvhrvldvkqvkkGetrsvkqfqlqswddmGvqkrpatlisilqlvkavservtantkastpilvhcsaGvG

RTGTYIAIDTLVKQCLDMGGMpNVDAVVRDMRLRRNYMVQT
|||..|.. ..... ..   . ..  .|. .|  |  ||.|
rtGvfislysalakvieesrv.difgfvkklrkdrpsmvet
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 25-246 1.3e-49 163.9 In-house 50-264 (439) alignment 
Range on Protein: 25-246
Range on HMM: 50-264/439.0
LKNRYGNIVAYDAGRVKLSQIGDDPSTDYINASWVDAYKQPNGYIASQGPVPNSFLDFWRMVWEQNACTIVMVTHEVEKGRikchrYWPDptstppTQTL
 |||| ...|.| .|| | .|   | . |||| ... | ... |||.|||  ..  ||||.|.|... ||||.|  ||  .     |||        .  
tknrykdvgafdhtrvtlqeipgvphshyinanyikGyyddklyiatqgpkkettddfwrlviekktvtivmltnlvesyk.....ywps......daev

SYGDVTVTHLRAEAHRHFVVRTFLVRC----NSEERTVKQFAYTSWPDHGVPLTTAELLGFRNAVNAGTPNKDV-PIVIHCSAGVGRTGTYIAIDTLVKQ
 |||..|   |     ..|.| | |      .  |||| || |..|||. ||  .. .| |  |.|.   .... |.|.||||||||||| ||.|  ..|
cygdiavrvdrnielpnyvirgfkvfnerdttekertvlqfhyiawpdknvpaqashvldflrainsandkeeygpvvvhcsagvGrtGtiialdialeq

cLDMGGMPNVDAVVRDMRLRRNYMVQT
 | .    ... .|. .| .|. |||.
.lklenkvdikgivkvlrkqrkqmvqa
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 12-246 5.7e-49 161.5 In-house 22-251 (283) alignment 
Range on Protein: 12-246
Range on HMM: 22-251/283.0
DQPATASYANPNLLKNRYGNIVAYDAGRVKLSQIGDdpstDYINASWVD---AYKQPNGYIASQGPVPNSFLDFWRMVWEQNACTIVMVTHEVEKGRIKC
|..|. . |. |  |||. .||..|  ||.|         |||||...     ||| ..||..|.|. .   |||.||.......|||.|.  |  ||||
dldadiasadenkrknrnqeivpadqwrvelksesr....dyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfdekitaivmltklqedlrikC

HRYWPDPTstpptqTLSYGDVTVTHLRAEAHRHFVVRTFLVRCN-S--EERTVKQFAYTSWPDHGVPLTTAELLGFRNAVNAGTPNKDVPIVIHCSAGVG
 .|||         .  ||. |||  .  ... |... .|.| | |  ..  .  . .  | . |       |. |   .   | .|. |||.|||.|.|
sqyWPkrG......sedyGeftvtlrkettsnsfiikelllrvnssakstlllahyqvidWleygeqaiinslvkfnkvislqteskkgPivvhCstgiG

RTGTYIAIDTLVKQCLDMgGMPNVDAVVRDMRLRRNYMVQT
||...||. . ||. |    . .| |||. || .|  .|||
rtavfiaasasvkdalte.svvdvfavvkimreqrmmavqt
0051429 (Phosphotyrosine protein) phosphatases II 50-248 7.6e-48 158.8 In-house 3-212 (272) alignment 
Range on Protein: 50-248
Range on HMM: 3-212/272.0
STDYINASWVDAYKQ---PNGYIASQGPVPNSFLDFWRMvWEQNACTIVMVTHEVEKGRIKCHRYWP------DPTSTPPTQTLSYGDVTVTHLRAEAHR
 ..||||..|. | .   |. ...|.|| |..  ||||. .|..  |||....|.|.|| ||.||||       |.    ..| .||...||.|  | . 
lsgyiNardvggygrvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseelll

HFVVRTFLVR---CNSEERTVKQFAYTSWPDHGVPLTTaeLLGFRNAVNAgtpnkDVPIVIHCSAGVGRTGTYIAIDTLVkQCLDMGGMPN--------V
....|..|..    ..| |.| .. ||.|||||||  .  || . .....     . |...|||||..||||..|.. |. . ...  . .        .
dyilrellltlllsagearevmhlhytdwpdhgvpqea..llellellld.....ggpvlvHCsaGkdRTGtvvalllll.lgvsletivddYlltnlyl

DAVVRDMRLRRNYMVQTEV
...|. .| .| ..|||| 
eeaveelraqrpgavqtee
subfamily_CG7180_pd Subfamily CG7180 21-245 4.3e-46 151.9 In-house 40-274 (296) alignment 
Range on Protein: 21-245
Range on HMM: 40-274/296.0
NPNLLKNRYGNIVAYDAGRVKLSQIGDDPSTDYINASWVDAYKQPNGYIASQGPVPNSFLDFWRMVWEQNACTIVMVTHEVEKGRiKCHRYWPDPTstpp
. |. |||. ..| ||  || |.... . ..|||||..||.. ... ||  ..|. ..  .|||.|..... ..|..|.. .  . ... |||  .    
kenreknrdvkvvPyDynRvvLekldGeeksdYinavyvdsflkkkeyivteapkketvdefWrlvydeeisavvvLtktfdfak.mypsywpnks....

tqTLSYGDVTVTHLRAEAHRHFVVRTFLVRCN------------SEERTVKQFAYTSWPD-HGVPLTTAELLGFRNAVNAGTPNK-----DVPIVIHCSA
     ||.. |  .. .   ... ||| .  .             |.|.||.| .| |.  . ||| |. |. .|. |.    .        |.|...| 
..keqygeifveiveekqyanlkirtfkltkkivalteqekqvkaetRivklfqlteWeledkvPlstnalielrrrvrlwrekvdedpeegPvvvvssd

GVGRTGTYIAIDTLVKQCLDmGGMPNVDAVVRDMRLRRNYMVQ
|..|.| |.|||  . .     .  .|   |. .|  |. .|.
GasRsGvylaidanlelvek.eeevdvFeavktlrrsRpqLve
0041856 (Phosphotyrosine protein) phosphatases II 23-246 1.5e-44 147.1 In-house 1-156 (182) alignment 
Range on Protein: 23-246
Range on HMM: 1-156/182.0
NLLKNRYGNIVAYDAGRvklsqigddpSTDYINASWVDAYKQPNGYIASQGPVPNSFLDFWRMVWEQNACTIVMVThevekgrikCHRYWPdptstpptq
|| |||| .|. || .|            |||||.... .  .. .|| ||| .... ||.||..|..  |||..|         ...|||         
nldknrysdilpydhsr..........dldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt.........eelywp.........

tlsygdvtvthlraeahrhfvvrtflvrcNSEERTVKQFAYTSWPDHGVPLtTAELLGFRNAVNAgtpnKDVPIVIHCSAGVGRTGTYIAIDTLVKQcld
                             . .||.. |. |..|||||||  . ||| | ..|..    .. |...|||||||||||..|.. . |.   
.............................ellerlgiqylylpwpDhgvpd.ldelldfieevle....eggpvlVHCsaGvgRtgtlvaaylmkkl...

mgGmPNVDAVVRDMRLRRNYMVQT
  |  ... .|. .| ||. ||.|
..g.vsleeavklvrsrRpgmvit
subfamily_ptpA1_pd Subfamily ptpA1 23-219 8.8e-44 144.9 In-house 47-255 (418) alignment 
Range on Protein: 23-219
Range on HMM: 47-255/418.0
NLLKNRYGNIVAYDAGRVKLSQIGDDPSTDYINASWVDAyKQPNGYIASQGPVPNSFLDFWRMVWEQNACTIVMVTHEVEKGRIKCHRYWPDPTSTPPTQ
|  |||| ||.  .  ||.| .| |   .||||| ..|    |. .|..|||.||.  ||||||||. .  |||...| |. |||| ||||.        
ntsknrytnilpvnhtrvqlkkiqdkegsdyinanyidg.aypkqfictqgplpntiadfwrmvwenrcriivmlsresencrikcdrywpeqiggeqfs

TLSYG-------DVTVTHLRAEAHRHFVVRTFLVRCNSEERTVKQFAYTSWPDHGVPLTTAEL----LGFRNAVNAGTP--NKDVPIVIHCSAGVGRTGT
    |        | .  .  .  |  . |   .  . | | . |. |  |||| .|  |  .        |  |   |  ...|||..|||||||||||
iygngnevfgtysvelveviqdpereiitrnirltfegetrditqyqyegwpdhnipdhtqpfrqllhsitnrqnqiipssdrnvpiivhcsagvgrtgt

YIAIDTLVKQ
. .   ..|.
fctavimmkk
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 17-248 8.6e-43 141.5 In-house 35-264 (307) alignment 
Range on Protein: 17-248
Range on HMM: 35-264/307.0
ASYANPNLLKNRYGNIVAYDAGRVKLSQIGddPSTDYINASWVDAYKQPNGYIASQGPVPNSFLDFWRMVWEQNACTIVMVTHEVEKGRIKCHRYWPDPT
.   . |  |||| .. . | ||. .   |   ..||| | ..    .|. .|..|||  |.  .|| |. ...  ...|. . .| ..|||..|||   
veafsantdknryqdvkcqdkgrivvkfdg..lasdyihanylgiaikpkkficaqgplentqysfwamaiqekvesvimlckvielakikceqywplee

STPPT-----QTLSYGDVTVTHLRAEaHRHFVVRTFLVRCNSEERTVKQFAYTSWPDHGVPLTTAELLGFRNAVNAgtpNkDVPIVIHCSAGVGRTGTYI
    .     .|.|  .. . .|  . .    | |. |   .. ||.... .. |||.||| .    . . .||.    .   |.|.||||||||.|| .
gqklvfgeapntisvanlgakklapd.edlinvttlkvdwaqksrtiqhlqwenwpdrgvpqinltainlleavry...d.tnpvvvhcsaGvGrsGtiv

AIDTLVKQCLDMGGMPNVDAVVRDMRLRRNYMVQTEV
||  .  . ..     ... .|...| .|.| .|||.
aislvqdkmiaGinckdmkklveelrsqrhyaiqtea
0036282 (Phosphotyrosine protein) phosphatases II 51-247 1.3e-42 140.8 In-house 2-156 (174) alignment 
Range on Protein: 51-247
Range on HMM: 2-156/174.0
TDYINASWVDAYKQPNGYIASQGPVPnsfldFWRMVWEQNACTIVMVTHEVEKGRIKCHRYWPDptstpptqtlsygdvtvthlraeahrhfvvrtflvR
.||||||..| .  ....||.||| .     ||.|..|..  |.||...|.|.|. ||..|||.                                   .
sdyinaspldlsyitprliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe...................................l

CNSEERTVKQFAYTSWPDHGVPLTTAeLLGFRNAVNAGTPN-KDVPIVIHCSAGVGRTGTYIAIDTLVKQCLdmGGMPNVDAVVRDMRLRRNYMVQTE
 ...||.. |. |. ||||||| ..  || | ..|.    . .. |...||||||||||| .|.. . .. |   .. .. ..|| .|| | .||||.
redlerlgiqylylpwpDhgvpdlsi.llefvkfveealsedpggpvlVHCsaGvgRtGtlvaaylmlrgll..eslvdaldlvrelRlqrpgmvqtp
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 10-246 2e-42 139.9 In-house 27-278 (301) alignment 
Range on Protein: 10-246
Range on HMM: 27-278/301.0
GRDQPATASYANPNLLKNRYGNIVAYDAGRVKLSQI--GDDPSTDYINASWVDAYKQPNGYIASQGPVPNSFLDFWRMVWEQNACTIVMVTHEVEKGRIK
|.|...| .. . |   ||. ||. ||  |. |..    |  ...|||||..|.|.. . .||.|||. .   ||||..|..   .||||| . |. . |
gedksctvglseenkalnrfknitvyddnriilkpkpnldlcqreyinasyidgysekkkfiaaqgpmkktlvdfWrliwqekpvsivmvtnlkegtksk

CHRYWPDPTStpptQTLSYGDVTVTHLRAEAHRHFVVR-----------------TFLVRCNSEERTVKQFAYTSWPDHGV-PLTTAELLGFRNAVNAGT
|..|||. .     .. ..| .|||     ..  ||.|                 .| |. . . ..| |.  |.||..|| .     |    . . .  
ceqywpnsea....eseefgpftvtlvneqvyPdfvirqlnvkiqdgsnngyierkfkvksdksswdvlqlqvtdWpqdGvvreprtvLqviddvihrqq

PNKDVPIVIHCSAGVGRTGTYIAIDTLVKQCLDmGGMPNVDAVVRDMRLRRNYMVQT
     |.|.|||..|.|.|.|....  . ||    |  .|  |.. .|  .  .|.|
kigggpvvVHCSdtVsrsGvYcsvsiglEQcka.egVVdvfqvtkavrrskpgaVtT
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 20-247 1.4e-41 137.0 In-house 53-269 (290) alignment 
Range on Protein: 20-247
Range on HMM: 53-269/290.0
ANPNLLKNRYGNIVAYDAGRVKLSQIGDdpsTDYINASWVDAYKQPngYIASQGPVPNSFLDFWRMVWEQNACTIVMVTHEVEKGRIKCHRYWPDPTstp
.|... |||| ..|  |  || |.. .|    ||. | .|.  | .  .| .||.. .. .|.|||| .... .|||.   .|.|. ||..|.|.     
kntefkknrykdvvcndktrvilkdGyd...GdyvhanyvkGlkam..filtqGalkdtvidiwrmvlqekvaaivmlceliedGkakceqyypeke...

pTQTLSYGDVTVTH-LRAEAHRHFVVRTFLVRC--NSEERTVKQFAYTSWPDHGVPLTTAELLGFRNAVNAgtpnKDVPIVIHCSAGVGRTGTYIAIDTl
  ..|..|..||.  .  .   . . .|. ||   .  |  .| .   ||||. |.|.|  ||    ..         |.|.|||||.|||||..||.. 
.GevltfGeitvlcseeddkdaniikktlsvrdkdsGkehklkhlkikswpdksvalstlallrtlrilrk....asGpvvvhcsaGiGrtGtfvaiev.

VKQCLDMGGMPNVDAVVRDMRLRRNYMVQTE
  |.|  |   ..  .|| .|  |   || .
glqilldGkeldlldlvralrnsrlnsvqvd
0043147 (Phosphotyrosine protein) phosphatases II 48-247 2e-40 133.7 In-house 2-147 (172) alignment 
Range on Protein: 48-247
Range on HMM: 2-147/172.0
DPSTDYINASWVDAYKQPNGYIASQGPVPNSFLDFWRMVWEQNACTIVMVTHEvekgrikchrywpdptstpptqtlsygdvtvthlraeahrhfvvrtf
|...||||||..| |  |. .|| ||| .| . |||||..|..  .||..| .                                               
degsdyinasyldlyyipdrfiatqgplrntladfwrmlkelgithivnltel...............................................

LVRCNSEERTVKQFAYTSWPDHGVPlTTAELLGFRNAVNA-GTPNKDVPIVIHCSAGVGRTGTYIAIDTLVkqcLDMggmpNVDAVVRDMRLRRNYMVQT
|. .  .||.. |. |..||||||| ... || | . ..     ... |...||||||||||| .|.. .    |..    ... .|. .| .|...||.
lydpellerlgiqylylpwpDhgvp.llellleflefidellalspggpvlVHCsaGvgRtgtlvaaylml...lgl....sleeavalvrekRpgavqn

E
.
p
0049772 (Phosphotyrosine protein) phosphatases II 16-244 1.7e-39 131.8 In-house 39-263 (314) alignment 
Range on Protein: 16-244
Range on HMM: 39-263/314.0
TASYANPNLLKNRYGNIVAYDaGRVKLsQIGDDPSTDYINASWVDAYkqpNGYIASQGPVPNSFLDF----------WRMV--WEQNACTIVM-------
....  .|  |||| .|. .|  ||.| .  .  ..||||||.|| .   . .||.||| .. . ||          ||||  ...|  .|||       
lvadlflnrdknryldilpad.nrvil.pglpvsgsdyinasyvdgf...lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivmsrdevla

--------------VTHEVEKGRIKCHRYWPDPTstpptqtlsygdvtvthlraeahrhF-------VvrtflvrcnseERTVKQFAYTSWPDHGVPlTT
               .   ..| . . .....                                   .           ||.. .. .. .||...| ..
delsrLdaAlgKtpllildgngneptaadlellk.........................eelydpelf...........erlgikylripvpDgsap.ll

AELLGFRNAVNAGtpNKDVPIVIHCSAGVGRTGTYIAIDTLVKQCldmgGMpNVDAVVRDMRLRRN-----YMV
. .. | .....   .|. |...||.||.|||||..... |.|..    |. ... ...|.||.|       ..
edfdeflefieea..dkggpvlvHCkaGkgRtgtfvvaaylmkll....gv.sleealedvrlkRpinpnpgfi
0046846 (Phosphotyrosine protein) phosphatases II 44-247 3.4e-37 123.3 In-house 5-159 (176) alignment 
Range on Protein: 44-247
Range on HMM: 5-159/176.0
QIGDDPSTDYINASWVDAYKqpngYIASQGPVPNSFLDFWRMVWEQNACTIVMVTHEVEKGRIKCHRYWPDPTSTPPtqtlsygdvtvthlraeahrhfv
..|.|.. |||||.... ..    .|| |||.|... ||..|..|..  ..|..| |||.||.||..|||. ..                          
llgldldldyinanlilgsr....piatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgi.......................

vrtflvrcnseertvkQFAYTSWPDHGVPLTtAELLGFRNAVNAGTPNKdVPIVIHCSAGVGRTGTYIAIDTLVKqcldmGGMPNVDAVVRDMRLRRN-Y
                |. .. |||||||   . || . ....    ..  |...|||||.|||||..|.. | .     .   .|. ... .| .|  .
................qylhlpwpDhgvpdl.elllellefirealkeg.gpvlVHCsaGigRtgtlvaayllel.....ekglsveealalvreqRplg

MVQTE
.|||.
avqtp
subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 6-245 4.9e-36 118.8 In-house 17-253 (281) alignment 
Range on Protein: 6-245
Range on HMM: 17-253/281.0
FYDIGRDQPAT--ASYAN-PNLLKNRYGNIVAYDAGRVKLSQ-IGDDPSTDYINASWVDAYKQPNGYIASQGPVPNSFLDFWRMVWEQNACTIVMVTHEV
| ..  | |.   . . .  |  |||| || . |  ||.|   . .  ||||| | .. .     ||| .|||  ..  |||||.|..|. .|||. . .
fsnlpgdppsdlctvfnqpvnnkknrylnipcldisrvqlkvkmpnknstdyihanyirspflkrgyiltqgpkketradfwrmiwqenttaivmlcqfl

EKGRIKCHRYWPDPTSTpptqTLSYGDVTVTHLRAEAHRHFVVRTFLVRCNSEERTVKQFAYTSWPDHGVPLTTAELLGFRNAVNAgtpnKDVPIVIHCS
|  | ||  |.|  .       | .  ..|..  .   . .|   . .  . | | . .. .  |||  || ..  .|     . |    .  | |||||
etnrekcaeyfprnahc....clqfdklsvsyedstvnkslvttrlnlsyegetrlithwlwkewpdwqvpessevmlkilrkira....rstppvihcs

AGVGRTGTYIAIDTLVKQCLDMGGMPNVDAVVRDMRLR-RNYMVQ
|||||.|| .|..  ..       .|..  .|  .|.  |   ||
agvgrsgtlmaveialqsihshftlpdikqivshlrvtgraasvq
0049260 (Phosphotyrosine protein) phosphatases II 59-247 1.4e-35 117.6 In-house 2-136 (152) alignment 
Range on Protein: 59-247
Range on HMM: 2-136/152.0
VDAYKQPNGYIASQGPVPNSFLDFWRMVWEQNACTIVMVTHEVEKGRIKCHRYWpdptstpptqtlsygdvtvthlraeahrhfvvrtflvrcnseertv
.| |..|. .|| ||| ||.. |||||..|... ||||.| ..|.|..||..|.                                              
idgyampfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi..............................................

kQFAYTSWPDHGVPLTTAELLGFRNAVNAGTPNKDVPIVIHCSAGVGRTGTYIAIDTLVkqcldmgGMPNVDAVVRDMRLRRNYMVQTE
 |. .. |||||||  .  || .  ...    .|. |...|||||||||||..|.. .           ... .|. .| .|...|...
.qylhlpwpDhgvpdlsqlllflllfieklaldkggpvlVHCsaGvgRtgtlvaaylml.......lgvsleeavalvrekRpgavpnp
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 20-248 2e-35 116.9 In-house 52-276 (305) alignment 
Range on Protein: 20-248
Range on HMM: 52-276/305.0
ANPNLLKNRYGNIVAYDAGRVKLSQIGddpSTDYINASWVDAYKQPN-GYIASQGPVPNSFLDFWRMVWEQNACTIVMVTHEVEKGRIKCHRYWPDPTST
|. .  |||| .. . |   |||..      .||| | .| .   |.  .|..|||. ..  .|| || ...   |||. . || |..|| .|||     
adiaitknryqdvpcqdqsavkldkps...psdyihanyvgcpmipekrficaqgpldqtidefwwmviqnkveqivmlcktvelgklkcaqywpaaqge

ppTQTLSYGDVT--VTHLR-AEAHRHFVVRTFLVRC-NSEERTVKQFAYTSWPDHGVPLTTAELLGFRNAVNAgtpnKDVPIVIHCSAGVGRTGTYIAID
   ..|  | |   |.  .  |      . .. .    ... .|... .| ||| |||      | .  |.        ||||.|||||.||||| .||.
..klelksgivvenvsgskpmerdaeiqitllnltysgdqkmsvrhlqwtewpdrgvppckltslellsairg....skvpivvhcsagigrtgtivaie

TLVKQCLDMGGMPNVDAVVRDMRLRRNYMVQTEV
 ....  .    | .  .|. .| .| . .|..|
yilekiaenkpcppmpelvkalrdqrafsiqndv
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 16-185 4.4e-35 116.0 In-house 26-193 (297) alignment 
Range on Protein: 16-185
Range on HMM: 26-193/297.0
TASYANPNLLKNRYGNIVAYDAGRVKLSQIgdDPSTDYINASWVDAYK--QPNGYIASQGPVPNSFLDFWRMVWEQNACTIVMVTHEVEKGRIKCHRYWP
...  |  | |||| .|.|.|  |||| .    . .||||| .|   .  ..  || .|||. ..  |||..|.||.  .||||..  | || ||  |||
ssakrnsslrknryrdilatddtrvkllrv..iterdyinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmvaklqedGrdkcapywp

DPTStpptQTLSYGDVTVTHLRAEAHRH--FVVRTFLVRCNSEERTVKQFAYTSWPDHGVPLTTAELLGFRNAV
.       . |  ||| | .|   .  .   ..  . .   ||.| |.   . ||||||||    .|  |.  |
svvq....erlkagdvvveflsstsdefdrviltelqliyrsesrvvrhvqflswpdhGvpsdledlvrfqaqv
0051082 (Phosphotyrosine protein) phosphatases II 50-247 4.6e-35 115.8 In-house 2-139 (151) alignment 
Range on Protein: 50-247
Range on HMM: 2-139/151.0
STDYINASWVDAYkqpngYIASQGPVPnsflDFWRMVWEQNACTIVMVTHEVEKGriKCHRYWPDPTstpptqtlsygdvtvthlraeahrhfvvrtflv
 .||||.|.|. .     ...|.|| .    ||.....|..  |||... |.| |  .|..|.|.                                   
lsdyinfsyvtgg.....lyrsggpla....dflellkelgiktivnlrseeerg..ycpeylpelg.................................

rcnseeRTVKQFAYTSWPDHGVPLTTAELLGFRNAVNAgtpNKDVPIVIHCSAGVGRTGTYIAIDTLVkQCldmggmPNVDAVVRDMRLRRNYMVQTE
      ..|... ...|||.|.||.....| | .....   .|. |...|||||.||||| .|.. .  .        .........||.| ..||..
......ievlhipildwpdpglplsfdavleflellld...kkngpvlvHCsaGkgRTGtlvalylml.lg......vsleealeeyrlkrpgvvqpn
0044763 (Phosphotyrosine protein) phosphatases II 35-247 6e-34 112.6 In-house 2-157 (178) alignment 
Range on Protein: 35-247
Range on HMM: 2-157/178.0
YDAGRVKLSQIGDDPSTDYINASWVDaykqPNGYIASQGPvpnsfLDFWRMVWEQNACTIVMVTHEVEKGRIKCHRYWPDPTStpptqtlsygdvtvthl
.|  ||.|| . . ...||||||...    |. |..|..|      |......|..  .||..|.|.| |..||..|||. ..                 
ldrtrvllsnleglersdyinaseil....pglylgslpp.....addlellkelgithivnlteelelgflkcdpywpeeag.................

raeahrhfvvrtflvrcnseertvKQFAYTSWPDHGVPLTTAELLGFRNAVNAGTPNKDVPIVIHCSAGVGRTGTYIAIDTLVKQcldmgGMpNVDAVVR
                         |. .. .||||||  .. .| | .....  ..|. |...||||||||.|| .|.. . |.     |. .......
........................iqylhipipDhgvpdllehflefvefieealdekggpvlVHCsaGvgRsgtlvaaylmkkl.....gl.sleeaie

DMRLRRNyMVQTE
 .| ||. .|...
lvrerRp.ivpnp
subfamily_CG42327_pd Subfamily CG42327 26-179 2e-32 107.1 In-house 31-184 (319) alignment 
Range on Protein: 26-179
Range on HMM: 31-184/319.0
KNRYGNIVAYDAGRVKLSQIGDDPSTDYINASWVDAYKQ-PNGYIASQGPVPNSFLDFWRMVWEQNACTIVMVTHEVEKGRIKCHRYWPDPTSTPPTQtl
|.|. |.|     || | .||||... |..||.|  |.. || |||.| .  .|  ||||.||||.. .|| .|   |.|  .| .|.|   . . |.  
ksrvinvvPlPetrvvlqrigdddkdeyldasyvrGyddapnsyiaaqvsledsssdfwrtvweqqsrvivqltdlselGikvcaeylPtketldnts..

SYGDVTVTHLRAEAHRHFVVRTFLVRC--NSEERTVKQFAYtSWPDHGVPLTTAELL
.|||. ||    |.. .... |.|..   ..| | .  . |  |.. .||   | |.
lyGdilvtlkgrevkdryaistlllkrvdkeesrelthywy.kwleaevPaeeaali
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 16-246 4.7e-32 106.1 In-house 26-244 (267) alignment 
Range on Protein: 16-246
Range on HMM: 26-244/267.0
TASYANPNLLKNRYGNIVAYDAGRVKLSQIGDDpstdYINASWVDAYKQPNGYIASQGPVPNSFLDFWRMVWEQNACTIVMVtHEVEKGRIKchRYWPdp
. |.|. |  .||. . . ||  || |..  ..    |||||.|..||. | .|. |.|. |.  ||. .. .|.  .||.. . | .. |.  ..||  
sqsiaeknqernrlddnlpyddtrvilrtkeee....yinasyvegyktknafivtqdplkntitdfltvihdqkvpvivll.tkvftdnir..lfwP..

tstpP--TQTLSYGDVTVTHLRAEAHRHFVVRTFLVRC-NSEERTVKQFAYTSWPDHGVPLTT-AELLGFRnaVNAGTPNKDVPIVIHCSAGVGRTGTYI
    |   |.  | |.|| |   .    . . |. ..  |   . |  . |  |            |.|     .    | . |.|..||.||||.||..
....Pkmgqakkyqdltvehslekeendyqiitlelkfknesahnvtlyyykkwnintnnkpylkplfgil..aknqlengnrPlvvacsdGvGrsGtfl

AIDTLVKQClDMGGMPNVDAVVRDMRLRRNYMVQT
 ||. ...     |. ..   .| .| .|  .|.|
vidsqlera.ktegvsdifdflrkirsqriglvdt
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 25-247 1.1e-31 104.7 In-house 50-273 (305) alignment 
Range on Protein: 25-247
Range on HMM: 50-273/305.0
LKNRYGNIVAYDAGRVKLsqIGDDPsTDYINASWVDAYKQPNGYIASQGPVPNSFLDFWRMVWEQNACTIVMVTHEVEKGRIKCHRYWPDPTstPPTQ--
 |||| ..   |  ||||   |  |  .|| | .| .  .|. .| .| |. ..  ||| | ....  .| |.   .|||  ||. |..      ..   
gknrykdvgcldnnrvkl..egpwp.heyihanyvstptnpkrfictqaplektcadfwymclqdkveaifmlcnllekgakkcleyfaskd..kdvlef

-------TLSYGDVTVTHLRAEAHRHFVVRTFLVRCN-SEERTVKQFAYTSWPDHGVPLTTAELLGFrnaVNAGTPNKdVPIVIHCSAGVGRTGTYIAID
       .. .   .  ..|..|. .     ...    .. | |... .  ||| ||| .   .| .   ..   | |  |||.|||||.||||. . ..
eekgqkisvkfessvtlkfrkdakakvtetvlviegpgekarkvthyhwidwpdrgvpaadlailel...lekarpsk.gpivvhcsagigrtgsvvmle

TLVKQCLDMGGMPNVDAVVRDMRLRRNYMVQTE
 ...| |    . . | ... .| .||  .||.
yildqllagqiiedtdkilqkireqrnnsiqtd
subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 17-247 4.6e-31 102.7 In-house 44-267 (301) alignment 
Range on Protein: 17-247
Range on HMM: 44-267/301.0
ASYANPNLLKNRYGNIVAYDAGRVKLSQigdDPSTDYINASWVDAYKQPNGYIASQGPVPNSFLDFWRMVWEQNACTIVMVTHEVEKGRIKCHRYWPDPT
 |||  .  |.|| ..       |.. .   |     | | |...  .|. .||.|||..|.  ||| |.   .  .|||....|||   ||. | |  .
esyaylpkdkhryptvPckPstaveviv...dGkrvPihanwiptsGhphrfiatqgPlkntsedfwamlvqydvekivmlgqkvekleekceeylpvki

StpPTQTLSYGDVTVTHLRAEAHRHFVVRTFLVRCNSE---ERTVKQFAYTSWPDHGVPLTTAELLGFRNAVNagtpNKDVPIVIHCSAGVGRTGTYIAI
|   .  .   ......     . . . ||. |.  ..    |||  . |..|.|.||| . |||  . . |     . . |||.|||||.||. ..|. 
s..ekldigrfkikiknkelilnkkiskrtlevedstgkfatrtvthyqysewtdrgvPkshaelfdlmelvk....ksekPivvhcsaGiGrsvafigt

DTLVKQCLDMGGMPNVDAvVRDMRLRRNYMVQTE
. | .. .    .   .| ....| .|   |||.
eylareveadptieltea.lkhlrehrwngvqtn
subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 13-248 6e-31 102.1 In-house 42-277 (310) alignment 
Range on Protein: 13-248
Range on HMM: 42-277/310.0
QPATASYANPNLLKNRYGNIVAYDAGRVKLsQIGDDPSTDYINASWVDAYKQPNGYIASQGPVPNSFLDFWRMVWEQNACTIVMVTHEVEKGRIKCHRYW
.  |    . .. |||| ..|  |. |||| .|      ||| | .| .    . .| ||||.  . .|||||.... | .|... . .|.|| ||  ||
ssltyeaykkymhknrysdvvcldtsrvkl.kidksryedyihanyvktnylrstficsqgplqhtiidfwrmifqeraesilllckvgeegrpkcvgyw

PDPTStpptqTLSYGDVTVTHLRAEAHrHFVV----RTFLV--------RCNSEERTVKQFAYTSWPDHGVPLTTAELLGFRNAVNAgtpnKDVPIVIHC
|         | .|| . || |   ..  | .     ||.          .| .|  |.   .  ||| |||      .  |   .     .  | |.||
pslgv.....tetygcirvtnlsesse.efeicnlavtfvpdnvpvdeqpanlkelrvslikwpnwpdrgvpdekchtvpqrllaqv....rhgpcvvhc

SAGVGRTGTYIAIDtLVKQCLDMGGMPNVDAVVRDMRLRRNYMVQTEV
|||..|... .|.. |  . || |   ... |. ... .|   .|||.
sagkdrlyvvvalk.lkidkldrglkvdaeevktellksraiciqtel
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 23-247 2.9e-29 97.0 In-house 43-257 (288) alignment 
Range on Protein: 23-247
Range on HMM: 43-257/288.0
NLLKNRYGNIVAYDAGRVKLSqigDDPSTdYINASWVDAYKQPNGYIASQGPVPNSFLDFWRMVWEQNACTIVMVTHEVEKGRIKCHRYWPDPTSTPpTQ
|  ..|| |.   |. |||||   |||   ||.|  | . | ..  | .| |.      .|.|. |..   |||... .|||. |   |.|       ..
nptrdryenlprcditrvkls...ddpdf.yiaanvvssakykrrlicaqaPlngtieelWkmllesdveyivmlcellekGkeksaeyfPsklGek.ar

TLSYGDVtVTHLRAEAHRHFVVRTFLVRCNSEERT-VKQFAYTSWPDHGVPLTTAELLGFRNAVnagtPNKDVPIVIHCSAGVGRTGTYIAIdTLVKQCL
   .  | | . ||. ..  .| .. .  . ||.  ||.  .  |.|.|||      | . . .     . . |||.|.||||||||| | |  .. . |
igrlctv.vkkkradidklvkvsllriskegeekvivkilhlleWdddgvPenylsplrllevl....kslqkPivvhssaGvGrtgtlili.lialesl

DMGGMPNVDAVVRDMRLRRNYMVQTE
 .     .  ..  .|  |   .|||
rlddflgirsllaklreerfkaiqte
subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 16-247 3.9e-29 96.5 In-house 30-256 (285) alignment 
Range on Protein: 16-247
Range on HMM: 30-256/285.0
TASYANPNLlkNRYGNIVAYDAGRVKLSQigddPSTDYINASWVDA-YKQPNGYIASQGPVPNSFLDFWRMVWEQNACTIVMVTHEVEKGRIKCHRYWPD
||  |||.|  ||| .. . .  || | .       ||| |||.    |. . ||..|||.|... |||.|..... . ..|.   .| |  ||  |.|.
tayeanpdl..nryadvrcieetrvvlkn....hdrdyihaswmrmpgkdqstyittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekcalyype

PTSTppTQTLSYGDVTVTHLRAEAHRHFVVRTFLVR----CNSEERTVKQFAYTSWPDHGVPLTTAELLGFRNAVNAGTPnKDVPIVIHCSAGVGRTGTY
         .   ..|.|  . ||    .. .. |     ..||   ...     |||.  |  .  .. . . |.   | |. ||..||||||||| |.
klge..vvkfgkyeitlteckeeaiagtilnaltvintedasseplymnhvqvpwwpdqlapedarpmielykwvkkvnp.kekpicvhcsagvgrtatf

IAIDTLVKQCLDMGGMPNVDaVVRDMRLRRNYMVQTE
. ||    . ..   .  .| .||.||  |   ||. 
vgidyatirimenpniemld.ivremramrfqavqsh
subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 27-218 9.8e-27 88.4 In-house 47-234 (312) alignment 
Range on Protein: 27-218
Range on HMM: 47-234/312.0
NRYGNIVAYDAGRVKLSqiGDDpsTDYINASWVDAYKQPNGYIASQGPVPNSFLDFWRMVWEQNACTIVMVTHEVEKGRIKCHRYWPDPTSTPP-----T
||| ||  .| ||  |.  ||.    || | .|    .|. ....|||. |.   ||...    ...|....  || |  || .|  |  .         
nrypniqcwdrgrftla..gde..nfyihanfvkictkperfvctqgplentcthfwqlalslgstsiillcgfvedgsekcakyisdivgfvdledhrv

QTLSYGDVTVTHLRAEAHRHFVVRtFLVRCNSEERTVKQFAYTSWPDHGVPLTTAELLGFRNAVNagtpNKDVPIVIHCSAGVGRTGTYIAIDTLVK
 | .  .. .     .   | |..  .|..  .|  .... ..||||||.| .    | .  ||.    .   |.. ||||||||||| . |.... 
yteycteieiggkskdkithrvlk.vvvkatgqesklnhyqwaswpdhgmpdscdtalrllsavk....kdkkpviahcsagvgrtgtlaliesmia
PTPc_DSPc_SM00012 157-247 3.9e-25 83.4 In-house 1-93 (105) alignment 
Range on Protein: 157-247
Range on HMM: 1-93/105.0
TVKQFAYTSWPDHGVPLTTAELLGFRNAVNAGTPNKD--VPIVIHCSAGVGRTGTYIAIDTLVKQCLDMGGMPNVDAVVRDMRLRRNYMVQTE
|||.. ||.||||||| .. ..| . .||.  . ...   |.|.|||||||||||..|.|.|..|. .  . ...  .|. .| .|. |||||
tvkhyhytgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqte
subfamily_egg_pd Subfamily egg 12-247 5.2e-23 76.2 In-house 29-256 (307) alignment 
Range on Protein: 12-247
Range on HMM: 29-256/307.0
DQPATASYANPNLLKNRYGNIVAYDAGRVKLSQIGDDPSTDYINASWVDAYKQPNGYIASQGPVPNSFLDFWRMVWEQNACTIVMVTHEVEKgrIKCHRY
... | .... || | |   .   |  ||||       . |.| |  |.     | .| .| |. |.  ||||||....   |||.|  .|    .|. |
eislttaasdnnlekarskrvhckdssrvklelrrGqylddfihanrvkGkpllnefilaqaplkntvddfwrmvfqeevqyivmltsrkes..erceyy

WPDPTSTPPTQTlsYGDVTVTHL--RAEAHRHFVV-RTFLVRCNSEERTVKQFAYtSWPDHGVPLTTAELLgfRNAVNAGTpnkdvPIVIHCSAGVGRTG
||   | .       | . .. |    .|   | | .  ||  . ||| .. . .  .   .   .  ..|  | . |. .     |.|...  || ...
wpkaesdslvtv..pGslrienlkvdskadplfrvtklklvGgddeerflehwqg.dvnnssdvysplrvl..rklrnlsk.....pvvvqdilGvskaa

TYIAIDTLVKQCLDMGG-MPNVDAVVRDMRLRRNYMVQTE
| .||.. . . |        |   |  .||||.. |.. 
tlvaieiallsllrGpitkslvlravvflrlrrrlsvesv
0048076 (Phosphotyrosine protein) phosphatases II 137-247 2.3e-21 71.4 In-house 26-129 (145) alignment 
Range on Protein: 137-247
Range on HMM: 26-129/145.0
EAHRHFVVRTFLVRCNSEERTVKQFAYTSWPDHGVPLTTAELLGFRNAVNAGTPNKdVPIVIHCSAGVGRTGTYIAIDTLVKqcldmGGmPNVDAVVRDM
. . .  | ..   .. .||.. |. |..|||||||  .. || | .....  ...  |...|||||||||||..|.. . .      |  ... ... .
kdlgittvlnltselellerlgiqylylpwpDhgvpdllellleflefieealkeg.gpvlVHCsaGvgRtgtlvaaylmll.....lg.vsleealelv

RLRRNYMVQTE
| .| ..|...
rsqrpgavpnp
subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 66-219 7.4e-21 69.2 In-house 5-161 (199) alignment 
Range on Protein: 66-219
Range on HMM: 5-161/199.0
NGYIASQGPVPNSFLDFWRMVWEQNACTIVMVTHEVEKGRIKCHRYWPDPTStpptQTLSYGDVTVTHLRAEAHRHFVVRTFLVRCNS----EERTVKQF
  |||.| |. ... |||.||||  .  ||||  .  .       |||   |     |  || ..||     ..  ... ....  |.      | . ..
rryiatqhplretmadfwqmvwetgsghivmvnddqknkeadypfywpttes....gtgkygslsvttktittkpdytitaliltnnttappstreishy

AYTSWPDHGVPlTTAELLGF----RNAVNAGTPNKDVPIVIHCSAGVGRTGTYIAIDTLVKQ
 .||| ..  |   | ..||    |.  .    .|| |...||| | | || ..|.|  |. 
qftswkekttp.nvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrs
subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 67-219 9.1e-21 68.9 In-house 5-160 (198) alignment 
Range on Protein: 67-219
Range on HMM: 5-160/198.0
GYIASQGPVPNSFLDFWRMVWEQNACTIVMVTHEVEKGRIKCHRYWPDPTStpptQTLSYGDVTVTHLRAEAHRHFVVRTFLVRCNS----EERTVKQFA
 |||.| |. ... |||.||||  .  ||||  .  .       |||   |     |  || ..||     ..  ... ....  |.      | . .. 
ryiatqhplretladfwqmvwetgsghivmvnddqknkeadypfywpttes....gtgkygslsvttktittkpdytitaliltnnttappstreishyq

YTSWPDHGVPlTTAELLGF----RNAVNAGTPNKDVPIVIHCSAGVGRTGTYIAIDTLVKQ
.||| ..  |   | ..||    |.  .    .|| |...||| | | || ..|.|  |. 
ftswkekttp.nvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrs
0048179 (Phosphotyrosine protein) phosphatases II 130-247 5.9e-20 66.9 In-house 32-131 (144) alignment 
Range on Protein: 130-247
Range on HMM: 32-131/144.0
TVTHLRAEAHRHFVVRTflvrcnseertVKQFAYTSWPDHGVPLTTAELLGFRNAVNAGTPnKDVPIVIHCSAGVGRTGTYIAIDTLVkqcldMGGMpNV
||  |. | . .|. |.           . |. ...|||||||  .. || | .....  . .. |...|||||||||||..|.. ..     . |. ..
tvinlteeyepeflere...........giqylhlpwpDhgvpdllellleflefieeale.eggpvlVHCsaGvgRtgtlvaaylmk.....klgl.sl

DAVVRDMRLRRNYMVQTE
. ... .| || ..|...
eealalvrsrrpgavpnp
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 25-114 1e-19 65.5 In-house 49-152 (350) alignment 
Range on Protein: 25-114
Range on HMM: 49-152/350.0
LKNRYGNIVAYDAGRVKLSQIGD--------DPSTDYINASWVDAY----K-QPNG-YIASQGPVPNSFLDFWRMVWEQNACTIVMVTHEVEKGRIKCHR
 |||| ||. |.  |||| .             . |||||...       . .|.  ||| |.|.|. . ||.... . .   |...| .|| .. ||.|
aknrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvkvilsltsdvelnlekcyr

YWPD
||..
YWqe
subfamily_eak_pd Subfamily eak 23-185 8.4e-18 58.8 In-house 52-207 (332) alignment 
Range on Protein: 23-185
Range on HMM: 52-207/332.0
NLLKNrYGNIVAYDAGRVKLSQIGDDPsTDYINASWVDAYKQPNGYIASQGPVPNSFLDFWRMVWEQNACTIVMVTHEVEKGRIKCHRYWPDPTStpptQ
.. .|   .|| ||   |.|.    ..   ||||| ..  .  . || .  .  .    ||.|| ||.. .||.. ..||..  |  .|.|| |     .
avnrn.vvkivpydrylvrltssqlnr.lGyinaslaefsevGrkyiltGiasedkvfafwqmvleqkspaivqlledvelkleksdkyfpdktr....e

TLSYGDVTVTHLRAEAHRHFVVRTFLVRCNSEERTVKQFAYTSWPDHGVPLTtAELLGFRNAV
 |..| . |.      .  . .| . ..   |   |. . .  | .  .|    ..| .|...
elkfGildverkefvkrniletrllelskGnethrvlhykvfGwtettlpky.edflalrkvm
subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 81-230 4.6e-16 53.6 In-house 43-188 (255) alignment 
Range on Protein: 81-230
Range on HMM: 43-188/255.0
DFWRMVWEQNACTIVMVTHEVEKGRIKCHRYWPdpTSTPPTQtlSYGDVTVTHLRaeAHRHFVVRTFLVRCN----SEERTVKQFAYTSWPDHGVPLTTA
 |....  ... ..||..   |.|. ||..|.|  .     .   . ||.||  .  .  . |.||  .  .     . .||| . |. |...  |  . 
kfyqtivqtktevvvmlcdfaeegvekcssyfp..lekdekl..kladvnvtttk..ssadvvlrtleitstlgekkkthtvkhysykGWieknaPelar

ELLGFRNAVNagtPNKdvPIVIHCSAGVGRTGTYIAIDTLVK---QCLDMGGMPNVD
|.|    .|      |  ..|.|||.|.||. ... .. . .   . ||     ..|
eilnilkvvr...dsk..svvvhCstGiGrsaafvlaelvyqkmirsldttetveld
subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 26-247 1.1e-15 52.5 In-house 22-245 (290) alignment 
Range on Protein: 26-247
Range on HMM: 22-245/290.0
KNRYGNIVAyDAGRVKLSQIGDDPSTDYINASWVDaYKQPNGYIASQGPVPNS-------FLDFWRMVWEQNACTIVMVTHEVEKGRI----KCHRYWPD
..|. . ..  | || | . |   . ||| |. |  . .    |..| |  .          .|| |. . ..  .||.    || .      | .| |.
dqRlevpLv.eatrvvLkgygkrfnddyiHAnrvt.cpnglrliltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCakYvpe

PTSTpptqTLSYGDVTVTHLRAEAHRHFVVRTFLVRCNS-EERTVKQFAYTSWPDHGVPLTTAELLGFRNAVNagtpNKDVPIVIHCSAGVGRTGTYIAI
   .     | ....||     |..  . .|. .|. .  || ||.   . .| .  |. .|  ||   . |.    ... |...||  |. |  .  ||
svge....elkfkgltvkCkskekeddvetRelvvkfddeeeftvtHsllkgWnklnvqedtktllsliqkvk....asktpvivHcvdGiSrsAalaai

DTLVKQCLDMGGMPNVDAVVRDMRLRRNYMVQTE
.       .. |  .. .|. ..| .|. .....
ilgyQkiaetsgsvkledvlkalrkqralaitsa
subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 80-248 6.3e-15 49.4 In-house 105-275 (302) alignment 
Range on Protein: 80-248
Range on HMM: 105-275/302.0
LDFWRMVWEQNACTIVMVTHEVEKGRIKCHRYWPDPTStpptQTLSYGDVTVTHLRA-------EAHRHFVVRTFLVRCN----SEERTVKQFAYTSWPD
  .| .. . | . .| ... ||..  ||  |. |       ..| .|  ||. .            ..|.. |  .. .      ..||. .|...|||
ekhwalieqynvaivvqlcsfvedeekkcaeyysdkvg....gelkfgrytvktvsvktdleeftdkksfklytveiknekkkkkvkktvdilafsawpd

HGVPLTTAELLGFRNAVNAgtPNKDvpIVIHCSAGVGRTGTYIAIDTLVKQCLDMgGMPNVDAVVRDMRLRRNYMVQTEV
|| |  .   |   .  ..    |.  ...||||||||||| .||   .. |.    . ..  .|  .|  |   ||.| 
hGapkeaytaldilkfces..ykkn..vlvhcsaGvGrtGtlvaikyGiqlcskk.kvtdllsivlpvrqcryGavqdeq
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 153-247 7.7e-15 49.1 In-house 86-180 (440) alignment 
Range on Protein: 153-247
Range on HMM: 86-180/440.0
SEERTVKQFAYTSWPDHGVPLTTAELLGFRNAVNAGTP-NKDVPIVIHCSAGVGRTGTYIAIDTLVKQCLDMGGMpNVDAVVRDMRLRRNYMVQTE
 | ||.||. | .|||.|||  .. .| . . ||       . |...|||||.||||  ||.|......     . .. ...  ||  |  |||| 
iesrtlkqyhyqgwpdkgvpkfagpvlkmiqdvnesqekagngpllvhcsagagrtgviiavdsilreakrsdqi.difsfinsmrnnrpqmvqtp
subfamily_hpo-7_pd Subfamily hpo-7 81-225 2.5e-13 44.5 In-house 49-189 (263) alignment 
Range on Protein: 81-225
Range on HMM: 49-189/263.0
DFWRMVWEQNACTIVMVTHEVEKGRIKCHRYWPdpTSTPptQTLSYGDVTVTHLRAEAhrHFVVRTFLVRC----NSEERTVKQFAYTSWPDHGVPLTTA
 |....  ... ..||..   |.|. || .|.|  .     . . . .|.|.  ..      ...|  .        . .|||.. |. |...  |  . 
kfyqtivqtktevvvmLcDfneegvekcssyfP..lekd..ekqklanvnvcttkvqs..dvllktlellstlgeKkkthtvkhysykgWiekndpelar

ELLgfrNAVNAGTPNKdvPIVIHCSAGVGRTGTYIAIDTLVK---QCLDMGG
| |   | ... .  |  ..|.|||.|.||.  .  .... .   . ||   
eil...nilkvarnsk..slvvhcstGiGrsaafsvaElvyqkmirsldtts
subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 18-145 2.7e-13 44.1 In-house 91-207 (244) alignment 
Range on Protein: 18-145
Range on HMM: 91-207/244.0
SYANPNLLKNRYGNIVAYDAGRVKLSQiGDdPSTDYINASWVDAYKQPNGYIASQGPVPNSFLDFWRMVWEQNACTIVmVTHEVEKGrikcHRYWPDptS
..   |  ||| |  . .|  || ||. |   .  |||||.|    .   || .| |. .. .|||.|. |.    .| |   ||.       ||||  |
afnpnnswknregaglpfdfnrvplsk.gs.mgntyinasfvgclgrtaeyiltqhpladtsmdfwkmmlerhvnvlv.vlgsveee....deywpd..s

TPpTQtLSYGDVTVTHLRAEAHRHFVVR
 |  .     |.|||    .  .     
ep.le.wyeeditvtltdrdefknikas
subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 23-246 3e-13 43.9 In-house 51-270 (302) alignment 
Range on Protein: 23-246
Range on HMM: 51-270/302.0
NLLKNRYGNIVAYDAGRVKLSQIGDdpstDYINASWVDAYKQPNGYIASQGPVPNSF---LDFWRMVWEQNACTIVMVTHEVEKGRiKCHRYWPDPTSTP
|| ||.  .. ..|. .|||..  |    .|.||| |.  .  .  | .| |. .|     .|||||....  ..|..  | |  .   . ..|  . . 
nlkknqsedvpildsnlvkleaepd....syvnaskvevPeltrsiilaQlpkvdsedsveeFWrmvfqekivsvvilvgeeelkk.tlselfpkksgdy

P-TQTLSYGDVTVTHLRAEAhRHFVVRTFLVRCnSEERTVKQFAYTSWPDHGVPLTTAELLGFRNAVNAGTPNKDVPIVIHCSAGVGRTGTYIAIDTlVK
   ...      | .  .|.  ..|.  .   | |.   ..    | |... ||   |||      | | . . | ..||    |.|| |. ..  . . 
keygkmfvNnrkVekaeeek.tryviEvlPegc.snsvlanvyvltnWkqkkvpvkyaeliktaakvfakkikadentvivSknGaGRagafltlav.av

QCLDMGGMPNVDAVVRDMRLRRNYMVQT
..|. |  ||.  .|. .|  |  .|..
eklqkgkepnikeivksiRsqRpravds
subfamily_Sponge-PTP3_pd Subfamily Sponge-PTP3 14-73 2.2e-12 41.0 In-house 39-95 (95) alignment 
Range on Protein: 14-73
Range on HMM: 39-95/95.0
PATASYANPNLLKNRYGNIVAYDAGRVKLSQIGDdpsTDYINASWVDAYKQPNGYIASQG
| |.  .. |. |||. ||. ||| || |.   |   .||||| .|| | . | |||.||
pytvgsseanipknrflnifpydatrvvlttkrd...sdyinacfvdgyarkncyiaaqg
subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 21-157 2.3e-11 37.8 In-house 35-177 (347) alignment 
Range on Protein: 21-157
Range on HMM: 35-177/347.0
NPNLLKNRYGNIVAYDAGRVKLSQ-----IGDDPSTDYINASWVDAYKQPNGYIASQGPVPNSFLDFWRMVWEQNACTIVMVTHEVEKGRIKCHRYwPDP
. .| |||  .    || || ||         |..  ||||| .   .  . || .| |.|..  |||.||   .   .| .   ..   |.  .  .  
ekslsknrskdvklidatrvvlspeksknsraddvetyinashikfdnaskeyiltqyplpdtvrdfwkmvsvtkvtqvvtifepikdeaieefan.atl

TSTPPTQTLSYGDVTVTH--LRAEAHRHFVVRTFLVRCNSEERT
. ..|. | |  |.  .   .   |.    ...  .||.|.   
slvapaptasskdigsspvpidqiarereqieiksircesnlhr
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 156-223 3.9e-11 37.3 In-house 215-292 (350) alignment 
Range on Protein: 156-223
Range on HMM: 215-292/350.0
RTVKQFAYTSWPDHGVPLTTAELLGF----------RNAVNAGTPNKDVPIVIHCSAGVGRTGTYIAIDTLVKQCLDM
  | |. .  |.| .. |   ..|             .| .    ..  ||..|||||||||||....| |... ...
yvvyqlqvknWkDlslllnPesilqalevkndliddlfaeshldnarsspilvhCsaGvGrtGtlvtlDsllsdfeil
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 60-150 5.1e-11 36.5 In-house 230-312 (440) alignment 
Range on Protein: 60-150
Range on HMM: 230-312/440.0
DAYKQPNGYIASQGPVPNSFLDFWRMVWEQNACTIVMVTHEVEKgriKCHRYWPDPtstppTQTLSYGDVTVTHLRAEAHRHFVVRTFLVR
. | . | .||.| |.  . |||||.| . .  ||.|.    .|    |  |||       |.....|  || |  .|      |||. ..
egyskknafiatqmpldstvldfwrlvhdyristiimlnqlndk...tcsiywpvn.....trsvtfgpftvghkgsenmnrvkvrtlelk
subfamily_Cele-PTP-12_pd Subfamily Cele-PTP-12 22-106 6.6e-11 36.3 In-house 33-116 (332) alignment 
Range on Protein: 22-106
Range on HMM: 33-116/332.0
PNLLKNRYGNIVAYDAGRVKLSQigDDPSTDYINASWVDAYKQPNGYIASQGPVPNS-FLDFWRMVWEQNACTIVMVTHEVEKGRI
 |.  ||   . ..|  ||.|.   .|   |. |||||| | . . || .| |. .     ||||| |..   |...    || . 
nnmdmnriphlycfdhsrvelap..qdgkddfynaswvdgyskksayifaqapfndhteyvfwrmvserkpsmilvfgdidekqkr
subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 23-215 1.1e-10 35.6 In-house 47-233 (303) alignment 
Range on Protein: 23-215
Range on HMM: 47-233/303.0
NLLKNRYGNIVAYDAGRVKLSqigdDpsTDYINASWVDAYKQPNgYIASQGPVPNSFLDFWRMVWEQNACTIVMVTHEVEKGRIKCHRYWPDPTSTpptq
|. |||. ...  |  .||||    |  . || ||...   . .  | .| |.. .  |||.|. ||.   ....  . |  ..  .  .|         
nmdknrfvdvicldhskvkls....d..ssyihasyleldsskk.ailtqlplshtaadfwqmiieqkvkcvlllltdseydklggdsvfprnqdf....

tLSYGD--VTVTH-LRAEAHRHFVVRTFLVRCNSEERTVKQFAYTSWPDHGVPLT-----TAELLGFRNAVNAGTPnkDVPIVIHCSAGVGRTGTYIAID
 | . .  . |    | |    .|..   |   .    ..   | .||   .|         ..   .  .   ..    | |    .|.||.||.  ..
.lkfeersirvgefkrvelgdgwvlkvlsvsngdyksflhvhhykawphnsipsdgspkfvkqiwqlqsvlrkysd..stptvymslsgcgragtfalfe

T
|
t
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 26-114 6.9e-10 32.8 In-house 51-155 (349) alignment 
Range on Protein: 26-114
Range on HMM: 51-155/349.0
KNRYGNIVAYDAGRVKLSQIGDDP-----S---------TDYINASWVDA--YKQPNGYIASQGPVPNSFLDFWRMVWEQNACTIVMVTHEVEKGRIKCH
|||| .|. |.  |||| .    .     |          ||||| ..    ..  . ||| | |.| .  ||....  ..   .. .... |..  ||.
knrykdilPyehsrvklkkslksskvikastsesdsgklddyinanylkltrisvekkyiatqaPlPstvddfykvillngvklvlsLnddkelslekcd

RYWPD
.|| .
iywqe
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 187-246 1.2e-09 32.5 In-house 223-280 (297) alignment 
Range on Protein: 187-246
Range on HMM: 223-280/297.0
AGTPnKDVPIVIHCSAGVGRTGTYIAIDTLVKqCLDMGGMPNVDAVVRDMRLRRNYMVQT
|  | .......||||||||.|  .  |....  |  . .|.| |... .| .|  .|||
aemp.rnayllvhcsaGvGrsGvvvlsdvila.klrkkripdvaailsilreqrarlvqt
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 10-61 5.7e-09 29.8 In-house 34-85 (440) alignment 
Range on Protein: 10-61
Range on HMM: 34-85/440.0
GRDQPATASYANPNLLKNRYGNIVAYDAGRVKLSQIGDDPSTDYINASWVDA
|  ||.  .    | .|||| ||.|||  || | ..   |..||||||....
glsqpsdiaslpnnkvknryrnilaydhsrvmleevkgvpdsdyinasying
0038934 (Phosphotyrosine protein) phosphatases II 157-244 5.7e-09 31.4 In-house 78-160 (194) alignment 
Range on Protein: 157-244
Range on HMM: 78-160/194.0
TVKQFAYTSWPDHGVPLTTAELLGFRNAVNAGTPN-KDVPIVIHCSAGVGRTGTYIAIDtLVKQcldmGGMpNVDAVVRDMRLRRNYMV
   ..    .||.|.. ... || | ..|.  . . ..  ...|| ||.||||| .|   |..      || .... .. .| .|. ..
agieylklpfpddgtvPsleillrfldlvdeflnedpggvvaVHCkaGlgRtGtlvaaY.Liyr....lgm.saeeAialfrekRpgai
subfamily_CG42327_pd Subfamily CG42327 186-246 4.1e-08 27.3 In-house 240-300 (319) alignment 
Range on Protein: 186-246
Range on HMM: 240-300/319.0
NAGTPNKDVPIVIHCSAGVGRTGTYIAIDTLVKQCLDMGGMPNVDAVVRDMRLRRNYMVQT
 .|| ..  |.|.||| ||||||. || |  ...  .     ..  .|  .|  |   |.|
rsgtresqGPlvvhcsdGvGrtGlviasdiairsleeskrsvdiPqlvssvrrdrasavlt
subfamily_Sponge-PTP-2_pd Subfamily Sponge-PTP-2 23-103 6.4e-08 25.7 In-house 27-80 (169) alignment 
Range on Protein: 23-103
Range on HMM: 27-80/169.0
NLLKNRYGNIVAYDAGRVKLSQIGDDPSTDYINAswvdaykqpngyiasqgpvpnsfldfwRMVWEQNACTIVMVTHEVEK
|  |||    .|    |||| .. .| ..|||||                           ||.|| ||  ||..    .|
netknrpagplapshtrvklqrvmedlgsdyina...........................rmiwetnasvivvlgdtddk
subfamily_Sponge-PTP2_pd Subfamily Sponge-PTP2 23-103 7.8e-08 25.3 In-house 26-79 (169) alignment 
Range on Protein: 23-103
Range on HMM: 26-79/169.0
NLLKNRYGNIVAYDAGRVKLSQIGDDPSTDYINAswvdaykqpngyiasqgpvpnsfldfwRMVWEQNACTIVMVTHEVEK
|  |||    .|    |||| .. .| ..|||||                           ||.|| ||  ||..    .|
netknrpagplapshtrvklqrvmedlgsdyina...........................rmiwetnasvivvlGdtddk
subfamily_Sponge-PTP-4_pd Subfamily Sponge-PTP-4 35-170 1e-07 26.3 In-house 5-125 (130) alignment 
Range on Protein: 35-170
Range on HMM: 5-125/130.0
YDAGRVKlsqigddpSTDYINASWVDAYKQPNGYIASQGPVPNSFLDFWRMVWEQNACtIVMVTHEVEKGrikcHRYWPDptSTpPTQtLSYGDVTVTHL
..  |..          .|||||.|    . . |. .| |. .. .|||.|. |.    ...|   ||.       ||||  |  | .     |..||  
fevsrlq........gntyinasfvGllgrtaeylltqhpladtsmdfwkmmleryvn.vlvvlgsveee....deywpd..se.Ple.wyeediivtlt

RAEAHRHFVVRTFLVRCNSEE--RTVKQFAYTSWPDHG
  .  ..     . .  .  |  ...  |  . ||  |
drdefknikasnleiesdlneshqaltmfqisnwpsdg
PTEN_1 139-212 1.3e-07 26.6 In-house 67-149 (196) alignment 
Range on Protein: 139-212
Range on HMM: 67-149/196.0
HRHFVVRTFLVR------CNSEERTVKQFA--YTSWPDHGVPLTTAELLGFRNAVNAGTPNK-DVPIVIHCSAGVGRTGTYIA
. ..||.  . .      .. ||.  ...     ...|||.|     .   ... ..   ..    ...|| ||.||.|| .|
gitlvvnlseeeelsgrsydleeffksgveylhfpieDhgapslselfdicksfiewllsdpngnvVlVHCkaGlgRsGtvva
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 183-218 2.3e-07 24.5 In-house 255-290 (349) alignment 
Range on Protein: 183-218
Range on HMM: 255-290/349.0
NAVNAGTPNKDVPIVIHCSAGVGRTGTYIAIDTLVK
.| .    ..  ....||||| ||||... .| |. 
farlyldtdqlstllvhcsaGcGrtGvlvtldllls
subfamily_PTPDC1_pd Subfamily PTPDC1 162-251 6.5e-07 24.0 In-house 86-166 (182) alignment 
Range on Protein: 162-251
Range on HMM: 86-166/182.0
AYTSWPDHGVPlTTAELLGFRNAVNAGTPNKdvPIVIHCSAGVGRTGTYIAIDTLVKQCLDmgGmpnvDAVVRDMRLRRNYMVQTEVCIG
   .|.|.||. .  ..|     |.    ..   . .|| || ||||  ||   . .. |.  .    .  .. .| .|   .||  .. 
ynfgwkDygva.sleriLdivkvvafalqeg..kvavhChaGlGrtGvliacylvyakrlt..a....ekaiklvrskrpksiqtreqve
subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 151-241 3.8e-06 20.6 In-house 222-318 (347) alignment 
Range on Protein: 151-241
Range on HMM: 222-318/347.0
CNSEERTVKQFAYTSWPDHGVPLTTAELLGF-RNAVNAGTPN------KDVPIVIHCSAGVGRTGTYIAIDTLVKQCLDmGGMPNVDAVVRDMRLRRN
  ||    | .  |.|| .  |     .| . |  |.  ..       |  |.|. |  |. |. | .    ...| || |  |..|.. . || .| 
gcseatfakvyncttwpwkkypddekkvlalvrapvkesstslianleklapvvvmcdlgldrsatvvltsiiieqvld.gktpdcddlfkkmrdqra
subfamily_Sponge-PTP7_pd Subfamily Sponge-PTP7 197-216 6.9e-06 20.3 In-house 1-20 (69) alignment 
Range on Protein: 197-216
Range on HMM: 1-20/69.0
VIHCSAGVGRTGTYIAIDTL
|.|||.| |||||.|||   
vvhcssGtGrtGtfiaimve
subfamily_Sponge-PTP-7_pd Subfamily Sponge-PTP-7 196-244 7.2e-06 20.3 In-house 1-48 (69) alignment 
Range on Protein: 196-244
Range on HMM: 1-48/69.0
IVIHCSAGVGRTGTYIAIDTLVKQcLDMGGMPNVDAVVRDMRLRRNYMV
.|.|||.| |||||.|||   . . .    . ..   |. ||  |  ||
mvvhcssgtgrtgtfiaimvemar.ikseklvdifnnvqymrkcrpmmv
0048567 (Phosphotyrosine protein) phosphatases II 149-213 8.5e-06 20.2 In-house 21-97 (157) alignment 
Range on Protein: 149-213
Range on HMM: 21-97/157.0
VRCNSEERTVKQFAYTS-------WPDHGvPLTTAELLGFRNAVNAGT---PNKDVPIVIHCSAGV---GRTGTYIAI
.| ..   ....| ..        . |.| ||. | |  | . .|       ... .|..||.||    |||.| |. 
prlpkslynalyFsiddglvyedfffdfG.PlnlailyrFilklnkflkilelagkaiavhckaglkkrgrtatLigc