Gene MbrePTP-sf1-5 in Monosiga brevicollis

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily MbrePTP-sf1
Protein sequence
ID Type Fasta BLAST phosphatome Note
MbreP036_AA protein Get Run
MbreP036_AA_65-351 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 67-348 2.9e-121 398.9 In-house 1-280 (281) alignment 
Range on Protein: 67-348
Range on HMM: 1-280/281.0
KLRAQIKAHSANNNAGFIETFTSIRD-GLGSAATASRSDANQHLNRYSNIVAYDATRVLVPKNKENFNCDYVNANWIPS-EGPRKYIAAQGPVPASLVSF
.||...|..|.|.||||||....... |....||||..|.|.. |||||||||||||| | .|.|| |.||.|||..|. .|...|||.|||||||||.|
alrkhlkqlsqndnaGfieeyeklaaigvdntataskadenvlknrYsnivaYDatrvkvtpneenkntDYinanfvpgykgekeyiatqgPvPaslvaf

WQMVVEHDARLIVMLTNEIEGGKLKCHRYWPDDNMakashpqpvkKVKIGTYIVSFEGEESFPTYVHRKFKLYLESGEARDVSQMAYTAWPDHGVPATTK
||||.|.....|||.|.|||.|||||||||||||           ..|.|...|... ||. .||..|||||. ||||.|.|.|.|||||||||||||||
WqmvweqkvsaivmvtreieagklkChrYWPddns..........elkygdvtvkstaeeekatyierkfkleresgetreveqlaytaWPdhGvPattk

ELLGFRLAV-KDQLKRLNCTPLIHCSAGVGRTGTFIGLDRYIDRVLSK-RDADVLDIVRDMRRARNFMIQ----FVYLFLVCLDAMDQLE
|||.|| .| | . |. ... .||||||||||||.|.|||....| .. ...|| ..|...|..||.|.|    . ......|||.|. .
ellefrkevlkltekktkaplvihCsaGvGrtGtyialDrlvkaveaeleeldvkavvaelrkernlmvqtvvqyefvykavldaldkel
subfamily_PTPRD_pd Subfamily PTPRD 65-349 1.7e-79 263.0 In-house 7-286 (564) alignment 
Range on Protein: 65-349
Range on HMM: 7-286/564.0
SQKLRAQIKAHSANNNAGFIETFTSIRDGLGSAATASRSDANQHLNRYSNIVAYDATRVLVPKNKENFNCDYVNANWIPS-EGPRKYIAAQGPVPASLVS
 ..|.. ..   ||... | | . .|. |  .  .|.. .||.. |||.||||||..||   | . . ..||.||..| . . ...|||.|||.. ..  
vaelkehvaklkansdlkfeeeykkieegqqftweaankpaNkaKNRyanivaYdhsRVvLskvegdegsDYINAsfidgyrkrkayIAtqgPlaetied

FWQMVVEHDARLIVMLTNEIEGGKLKCHRYWPDDNmaKAshpqpvkkvKIGTYIVSFEGEESFPTYVHRKFKLYL-ESGEARDVSQMAYTAWPDHGVPAT
||.|| |.. . |||||.  | || |||.|||...  ..         ..| ..|..| || . .|. |.|||   .| |.| | |  .|.||||||| .
FWRmvweqnsstiVmltkleEkgkvkchkYWPekg..te.........tygeltVtleeeeeladyeirtfklkkkkssesreVrqFhFtsWPdhgvpes

TKELLGFRLAVKDQLKRLNCTPLIHCSAGVGRTGTFIGLDRYIDRVLSKRDADVLDIVRDMRRARNFMIQ----FVYLFLVCLDAMDQLEK
...|| ..  |..  .. .   ..||||||||||||| .|  ..|. .... |.  .|. .|. ||.|.|    ..... . |.|..  ..
atslLdlirkvralnepdagPivVhCSaGVGRTGtfividamlerikeektvDiyqyvkalrkqRnamVqteeQYiFiheailealacgnt
subfamily_PTPRB_pd Subfamily PTPRB 66-338 5.6e-75 247.1 In-house 10-275 (293) alignment 
Range on Protein: 66-338
Range on HMM: 10-275/293.0
QKLRAQIKAHSANNNAGFIETFTSIRD-GLGSAATASRSDANQHLNRYSNIVAYDATRVLVPKNKENFNCDYVNANWIPS-EGPRKYIAAQGPVPASLVS
.|. . .|  .|.....| | . .... |   | .|... .|.  |||.||..||..|| . . |.. . ||.|||.||  . ||..||.|||.| ..  
ekfeehvkkmkadsdlrfseeyeelkavgkdqavkaaelavnraknrytnilpydhsrvkLaalkdesgsDYinanyipgynsprefiatqGPlpetvdd

FWQMVVEHDARLIVMLTNEIEGGKLKCHRYWPDDnmakashpqpVKKVKIGTYIVSFEGEESFPTYVHRKFKLYLeSGEARDVSQMAYTAWPDHGVPATT
||.|| |. .. |||||. .|.|| ||..|||.|           . |  |   |..  ||.   .| |..|.   . | |.| |. .|.||||||| .|
fWrmvwekkssiivmltqlvekgkvkCeeYWPad..........eepvlyGdikvtlvaeeeledwvirelkiek.ekeerkvrqyhftsWpdhgvPekt

KELLGFRLAVKDQL-KRLNCTPL-IHCSAGVGRTGTFIGLDRYIDRVLSKRDADVLDIVRDMRRARNFMIQFVYLFL
| || |  .|.... |  . .|. .||||||||||||| ||| .... ..   |.. || ..|. ||...| .  ..
ktlldfvrtvreaiektaskrPivvhCsaGvGRtGtfialdrllqaieeedyvdifgivaelReeRnllvqtekqYi
0051299 (Phosphotyrosine protein) phosphatases II 66-344 4.4e-74 244.8 In-house 8-282 (288) alignment 
Range on Protein: 66-344
Range on HMM: 8-282/288.0
QKLRAQIKAHSANNNAGFIETFTSIRDGLGSAA-TASRSDANQHLNRYSNIVAYDATRVLVPKNKENFNCDYVNANWIPS-EGPRKYIAAQGPVPASLVS
..|.  .... ||...|..| |  ... | .   .|..  .|.. ||||.|..|| .|| .   ... ..||.||..|.  . .||.||.||| | .. .
eellklvlkllangltglleefeellsllpdltlsaallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyidgynlkrkfIatqgPlpntved

FWQMVVEHDARLIVMLTNEIEGGKLKCHRYWPDDNMAKAshpqpvkkvkiGTYIVSFEGEESFPTYVHRKFKLYL-----ESGEARDVSQMAYTAWPDHG
||.|| |.. |.|||||...| |. ||..|||.... .            | . | .  ||....|..|....        .|| | | .. ||.|||||
FWrmvweqnvrvIvmltklvelgrekcaqYwplggslty...........gditvtllseevlddytvrtlevtnldlldgdgesrtvthfhytnwpdhg

VPATTKELLGFRLAVKDQLKRLNCTPLIHCSAGVGRTGTFIGLDRYIDRVLSKRDADVLDIVRDMRRARNFMIQFVYLFLVCLDAM
|| ....|| |  .|...|.  ... ..||||||||||||| ||  ..... ..  |||..|. .|. |..|.| .  .. . .|.
vpdspellldflrlvrkalasgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtpeqyrfvyeal
0050432 (Phosphotyrosine protein) phosphatases II 76-345 4.9e-73 241.5 In-house 37-296 (308) alignment 
Range on Protein: 76-345
Range on HMM: 37-296/308.0
SANNNAGFIETFTSIRDGLGSAA-TASRSDANQHLNRYSNIVAYDATRVLVpknkeNFNCDYVNANWIPSE---GPRKYIAAQGPVPASLVSFWQMVVEH
.|... .. | |  ...   .   ....  .|...|||..|..|| .|| .     . ..||.||....      |||.||.||| | .. .||.|| |.
kaldlglleeefeellsvkplleysvallpenkdkNrykdilpydhsRVkl.....degsdYInAsyvdgyssklprkfIatqgPlpntvedFwrmvweq

DARLIVMLTNEIEGGKLKCHRYWPDD---NMAKAshpqpvkkvkiGTYIVSFEGEESFPTYVHRKFKLYL-ESGEARDVSQMAYTAWPDHGVPATTKELL
. |.|||||...| |. ||..|||..   .  .            | . | .  ||....|..|...|   ..|| | | .. ||.|||||||  ...||
nvrvIvmLtklvengrekcaqYwplelgggsley...........gkftvtllseevlddytvrtleltnlgdgesrtvthfhytnWpdhgvPpspeill

GFRLAVKDQLkrLNCTPLIHCSAGVGRTGTFIGLDRYIDRVLSKRDADVLDIVRDMRRARNFMIQFVYLFLVCLDAMD
 |  .|...|   ... ..||||||||||||| ||  ....  ..  ||...|. .|. |..|.| .  .| . .|. 
dflelvrksl..pggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtpeqylflyrall
0040438 (Phosphotyrosine protein) phosphatases II 72-352 1.7e-72 239.7 In-house 9-280 (317) alignment 
Range on Protein: 72-352
Range on HMM: 9-280/317.0
IKAHSANNNAGFIETFTSIRDGLGSAATASRSDANQHLNRYSNIVAYDATRVLVPKNKENFNCDYVNANWIPSEG-PRKYIAAQGPVPASLVSFWQMVVE
..   .... .. | |  ...   .  . ..  .|...|||..|. ||..|| .   .. ...||.||....    .||.||.||| | .. .||.|| |
lldllksdftalleefedllslkldtysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyvdgpnlkrkfIatqgPlpntvedFwrmvwe

HDARLIVMLTNEIEGGKLKCHRYWPDDNMAKAshpqpvkkvkiGTYIVSFEGEESFPTYVHRKFKLYL-ESGEARDVSQMAYTAWPDHGVPATTKELLGF
.. ..|||||.. | |. ||..|||...  .            |...| . .||  . ...|.....  ...| | | .. ||.||||||| ....|| |
qgvtvivmLteleelgrekcaqYwplgetlty...........gdftvtllseeelagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldf

RLAVKDQLKRLNCTPLIHCSAGVGRTGTFIGLDRYIDRVLSKRDADVLDIVRDMRRARNFMIQFVYLFLVCLDAMDQLEKLLD
  ||...|.. ..  |.|||||||||||||.... ....  ... || ..|. .|..|. ..|    .  . ||. .. |  .
leavrealedpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalleylkrkl
0039614 (Phosphotyrosine protein) phosphatases II 71-345 1.5e-70 233.3 In-house 22-286 (297) alignment 
Range on Protein: 71-345
Range on HMM: 22-286/297.0
QIKAHSANNNAGFIETFTSIRDGLGSaATASRSDANQHLNRYSNIVAYDATRVLVPKNKEN-FNCDYVNANWIPSEG--PRKYIAAQGPVPASLVSFWQM
 .. . ||.. .... | .. .   .  . ... .|...|||..|..|| .|| .  ...  ...||.||....     .||.||.||| | .. .||.|
llllekansktllllefeellslkpd.ysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfIatqgPlpetvedFwrm

VVEHDARLIVMLTNEIEGGKlKCHRYWPDDNMakashpqpvkkvKIGTYIVSFEGEESFPTYVHRKFKLYLeSGEARDVSQMAYTAWPDHGVPATTKELL
| |.. . |||||...| |. ||..|||..              . |.. | . ..|  . |..|....   .|| | | .. || ||||||| ... ||
vweqgvtvivmLtklvelgr.kcaqywpeegg............tygdftvtllkvehldgytvrtlevtn.ngesrtvthfqytgwpdhgvppslelll

GFRLAVKDQLKR--LNCTPLIHCSAGVGRTGTFIGLDRYIDRVLSKRDADVLDIVRDMRRARNFMIQFVYLFLVCLDAMD
 |  .|...|..   ..  |.|||||||||||||.... .... .... |||..|. .|..|. ..|    .  . ||. 
eflelvrealaelpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydall
0046845 (Phosphotyrosine protein) phosphatases II 98-344 4.8e-70 231.5 In-house 20-270 (284) alignment 
Range on Protein: 98-344
Range on HMM: 20-270/284.0
ATASRSDANQHLNRYSNIVAYDATRVLVPKNKEN-FNCDYVNANWIPS------EGPRKYIAAQGPVPASLVSFWQMVVEHDARLIVMLTNEIEGGKLKC
 ....  .|...|||..|..|| .|| .   ...  ..||.||....         ..|.||.|||.| .. .||.|| |...|.|||||...| |. ||
lsvallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweqnvrvIVmltelvengrekc

HRYWPDDNMAKAShpqpvkkvkiGTYIVSFEGEESFPTYVHRKFKLYLE--SGEARDVSQMAYTAWPDHGVPATTKELLGFRLAVKDQLK--RLNCTPLI
..|||...  .            | ..| .  || ...|..|...|  .  .|| | | .. ||.|||||||.... || |  .|...|.    ... ..
aqYwplegevlty..........gdftvtllseevkddytvrtleltnlgytgesrtvthfhytswpdhgvppspedlleflrlvrellenlpgggpivV

HCSAGVGRTGTFIGLDRYIDRVLSKR---DADVLDIVRDMRRARNFMIQFVYLFLVCLDAM
||||||||||||| ||  ....  ..     |||..|. .|. |..|.| .  .. . .|.
HCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyeal
0043336 (Phosphotyrosine protein) phosphatases II 71-343 4.2e-69 228.4 In-house 10-272 (278) alignment 
Range on Protein: 71-343
Range on HMM: 10-272/278.0
QIKAHSANNNAGFIETFTSIRDGLGSAATASRSDANQHLNRYSNIVAYDATRVLVPKNKENFNCDYVNANWIPSEG-PRKYIAAQGPVPASLVSFWQMVV
 ..   .|....... | ....      . ... .|...|||..|..|| .|| .   .. ...||.||....    |||.||.||| | ..  ||.|| 
allelllnlktllllefeellsfkldtysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyvdgynvprkfiatqgPlpetvedFwrmvw

EHDARLIVMLTNEIEGGKLKCHRYWPddnmakashpqpVKKVKIGTYIVSFEGEESFPTYVHRKFKLYL-ESGEARDVSQMAYTAWPDHGVPATTKELLG
|.. . |||||.. | |. ||..|||             . ...|.. | . .||....|..|....    .|| | | .. |..||||||| ... || 
elgvttivmLtelvelgrvkcaqYwp............ggsltygdftvtllkeehlddytvrtlevtnlgdgesrtvthyhylgwpdhgvpeslsllld

FRLAVKDQLKRLNCTPLIHCSAGVGRTGTFIGLDRYIDRVLSKRDADVLDIVRDMRRARNFMIQFVYLFLVCLDA
|  ||...|.  |   |.|||||||||||||.|.. .... . .  |....|...|. |  ..|    .  . .|
flkavrealedsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflyea
0036941 (Phosphotyrosine protein) phosphatases II 77-347 7.1e-69 227.7 In-house 9-276 (297) alignment 
Range on Protein: 77-347
Range on HMM: 9-276/297.0
ANNNAGFIETFTSIRDGLGSAA-TASRSDANQHLNRYSNIVAYDATRVLVpknkENFNCDYVNANWIPSEG-PRKYIAAQGPVPASLVSFWQMVVEHDAR
....|.. . | .. . | .   ..... .|...|||..|..|| ||| .    .. ..||.||....  . .||.||.||| | .. .||.|| |.. .
llflalllkefeellpllllgslsvallpenleknRykdilpydhtRVkl....ddegsdYinAsyvdgydlkrkfIatqgPlpntvedFWrmvweqnvt

LIVMLTNEIEGGKLKCHRYWPDDNMAKASHpqpvkkvkiGTYIVSFEGEES--FPTYVHRKFKLYL-ESGEARDVSQMAYTAWPDHGVPATTKELLGFRL
 |||||...| |. ||..|||...     .         | ..| . ..|.  ...|. |.....  ..|| | | .. || ||||||| ....|| |  
vIvmltelvelgrekcaqywpleegeslty.........gdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfie

AVKDQLKR--LNCTPLIHCSAGVGRTGTFIGLDRYIDRVL---SKRDADVLDIVRDMRRARNFMIQFVYLFLVCLDAMDQL
.|...||    .   |.||||||||.||||..|  ....      .  |.|..|. .|. |....| .  .. . .|. .|
lvrkvlkllpsggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallel
0047943 (Phosphotyrosine protein) phosphatases II 77-343 2.2e-68 226.0 In-house 8-267 (273) alignment 
Range on Protein: 77-343
Range on HMM: 8-267/273.0
ANNNAGFIETFTSIRDGLGSAA-TASRSDANQHLNRYSNIVAYDATRVLVpknkENFNCDYVNANWIPS-EGPRKYIAAQGPVPASLVSFWQMVVEHDAR
........| |  ...   .   ....  .|...|||..|..|| .|| .    .. ..||.||....  . .||.||.||| | .. .||.|| |...|
llgltllleefelllslkplltysvallpenkdknrykdilpydhsrvkl....gdggsdyinAsyvdgynlkrkfiatqgPlpntvedfwrmvweqnvr

LIVMLTNEIEGGKLKCHRYWPDDnmakashpqpVK--KVKIGTYIVSFEGEESFPTYVHRKFKLYL-ESGEARDVSQMAYTAWPDHGVPATTKELLGFRL
.|||||...| |. ||..|||..          .   ... | ..| . .||....|..|...|.  ..|| | | .. || |||||||.....|| |  
viVmLtelvelgrekcaqYwple..........ggelsltygkftvtllseetkddytvrtleltnlgtgesrtvthfhytgwpdhgvppslesllefie

AVKDQLKR--LNCTPLIHCSAGVGRTGTFIGLDRYIDRVLSKRDADVLDIVRDMRRARNFMIQFVYLFLVCLDA
.|...|.    | . ..||||||||||||| ||  .|..  ..  |||..|. .|. |  |.| .  .. . .|
lvrkalealpsngpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrflyea
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 66-352 4.3e-68 224.7 In-house 5-284 (318) alignment 
Range on Protein: 66-352
Range on HMM: 5-284/318.0
QKLRAQIKAHSANNNAGFIETFTSI-RDGLGSAATASRSDANQHLNRYSNIVAYDATRVLVPKNKENFNCDYVNANWIPSE-GPRKYIAAQGPVPASLVS
..|. ...   .. .  . | .  . |.   .... | ...|.. ||| ||.||| |||.. . ... . ||.|||.|.     ..|||||.|.|  .  
edleshvrrlresGelllseeyerlsrseetvtslkslepvnkaknryanilaydhtrvkLqmlegeegsDyinanyidGyrrkkayiaaqaPlpetieD

FWQMVVEHDARLIVMLTNEIEGGKLKCHRYWPDDNmakashPqpvkkVKIGTYIVSFEGEESFPTYVHRKFKLYL-ESGEARDVSQMAYTAWPDHGVPAT
||.|| | ....|||||.| | || |.|||||...      .      ..|.  |  . | .. .|| |.||.   |. | |.| |  ||.|||.|||. 
fWrmvWeqnsavivmltqeeergkakvhryWPskg......s.....rsygklvvelkeevelsdyvlrefkvtrteeeesrqvrqyhytsWpdegvpes

TKELLGFRLAVKDQLKRLNCTP-LIHCSAGVGRTGTFIGLDRYIDRVLSKRDADVLDIVRDMRRARNFMIQFVYLFLVCLDAMDQLEKLLD
. .|| .   |.   .. . .| ..||||||||||.|| .|  ..|.      ||...|. .|. || |.|    . .. |.. .  .  |
gaslldlvrqvskaqqksgagpivvhCsaGvGrtGvfiavdillerikaealvDvfqtvkqlreqrnlmvqtedqyefiydvllealasgd
DSPc_SM00195 97-345 6.5e-68 224.3 In-house 17-259 (263) alignment 
Range on Protein: 97-345
Range on HMM: 17-259/263.0
AATASRSDANQHLNRYSNIVAYDATRVLVPKNKENFNCDYVNANWIPSE-GPRKYIAAQGPVPASLVSFWQMVVEHDARLIVMLTNEIEGGKLKCHRYWP
  | .. ..|.. |||.||. || ||| ..|.... . ||.|||.|  .  ..||||.||| |  . .||.||.|.. ..|||||.| | || ||.||||
etteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlteeeengkekcdrywp

DDNmakashpqpVKKVKIGTYIVSFEGEESFP-TYVHRKFKLYLES-GEARDVSQMAYTAWPDHGVPATTKELLGFRLAVKDQLKRLNCTPLIHCSAGVG
...          .| ..|.. | .  .|. .  .. |...|  |   |.|.| |. |..||||||| .||..| .  ||| . .. . . ..|||||||
ees.........ggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkkskstssgpivVhCsaGvg

RTGTFIGLDRYIDRVLSKRDADVLDIVRDMRRARNFMIQFVYLFLVCLDAMD
|||||. .|  .... .. . |. .||. .|  |  |.|    .|.. .|. 
RtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeail
PTPc_SM00194 97-345 6.5e-68 224.3 In-house 17-259 (263) alignment 
Range on Protein: 97-345
Range on HMM: 17-259/263.0
AATASRSDANQHLNRYSNIVAYDATRVLVPKNKENFNCDYVNANWIPSE-GPRKYIAAQGPVPASLVSFWQMVVEHDARLIVMLTNEIEGGKLKCHRYWP
  | .. ..|.. |||.||. || ||| ..|.... . ||.|||.|  .  ..||||.||| |  . .||.||.|.. ..|||||.| | || ||.||||
etteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlteeeengkekcdrywp

DDNmakashpqpVKKVKIGTYIVSFEGEESFP-TYVHRKFKLYLES-GEARDVSQMAYTAWPDHGVPATTKELLGFRLAVKDQLKRLNCTPLIHCSAGVG
...          .| ..|.. | .  .|. .  .. |...|  |   |.|.| |. |..||||||| .||..| .  ||| . .. . . ..|||||||
ees.........ggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkkskstssgpivVhCsaGvg

RTGTFIGLDRYIDRVLSKRDADVLDIVRDMRRARNFMIQFVYLFLVCLDAMD
|||||. .|  .... .. . |. .||. .|  |  |.|    .|.. .|. 
RtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeail
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 70-344 4.7e-67 221.0 In-house 10-275 (288) alignment 
Range on Protein: 70-344
Range on HMM: 10-275/288.0
AQIKAHSANNNAGFIETFTSI-RDGLGSAATASRSDANQHLNRYSNIVAYDATRVLVPKNKENFNCDYVNANWIPSE-GPRKYIAAQGPVPASLVSFWQM
|...  ||.|..|| | . |.   .  .. ||.|   |.. ||| ||..|| .|| . | .|. . ||.||..| .| . .||||.|||.....  ||..
akvakksarnrtgfseeynsLaalektksvtagrlavnakknRyrnilpyDekrvklkkleeeagaDYinasyidgekkkkkyiatqgPladtvndfWel

VVEHDARLIVMLTNEIEGGKLKCHRYWPDDNmakashpqpvKKVKIGTYIVSFEGEESFPTYVHRKFKLYlESGEARDVSQMAYTAWPDHGVPATTKELL
| |...  |||||. .|||| ||..||||..          |... |   |   ...    .|.||. |   ... ... |..|.||||||||. ...||
vyenktstivmltelveggktkCeeYWPdad..........kpknyGsvtvtlveskeledfvlrkllle.kkkteleitqyqylaWpdhgvPeskapll

GFRLAVKDQLKRLNCTPLIHCSAGVGRTGTFIGLDRYIDRVLSKRDADVLDIVRDMRRARNFMIQFVYLFLVCLDAM
...  || . .      ..||||||||||||| ||  ||.| ..   ||...|  .|. |....| .. .  . ...
ellrqvkvanqadtgpiivhCsaGvGrtgtFialdalidaveeedyiDvagtvaklRkqRallvqtlkqYefiyevl
0045098 (Phosphotyrosine protein) phosphatases II 91-343 2.7e-66 219.1 In-house 18-267 (278) alignment 
Range on Protein: 91-343
Range on HMM: 18-267/278.0
RDGLGSAATASRSDANQHLNRYSNIVAYDATRVLvpknkenfncDYVNANWIPSEgPRKYIAAQGPVPASLVSFWQMVVEHDARLIVMLTNEIEGGKLKC
. |  |  | .    |...|||..|..|| .||           ||.||..|..  |.|.||.||| |  . .||.|. |.. . |||||...|.|. ||
llgipseitpalylgnldknRykdilpydhsrVk..........dYINAsyidgy.pkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrekc

HRYWPDDNMAKAshpqpvkkvkiGTYIVSFEGEESFPTYVHRKFKLYL-----ESGEARDVSQMAYTAWPDHGVPATT--KELLGFRLAVKDQLKR----
..|||....              | . | .. || ...|..|.....      |..| | | .. |. ||||||| ..  | .| .   ... ||.    
aqywpeggslty...........gdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllasl

---------LNCTPLIHCSAGVGRTGTFIGLDRYIDRVlsKRDADVLDIVRDMRRARNF-MIQFVYLFLVCLDA
          ... |.|||||||||||.....  ....  ..  |.|..|. .|. |.. ..|    .  . ..
llsslllldsggpvlVHCsaGvgRtGtlvaaylmlell..eggvdlleavkelrsqRpglavqnleqyrflyef
0045450 (Phosphotyrosine protein) phosphatases II 73-343 2.3e-65 216.7 In-house 19-299 (307) alignment 
Range on Protein: 73-343
Range on HMM: 19-299/307.0
KAHSANNNAGFIETFTSIRDGLG---SAATASRSDANQHLNRYSNIVAYDATRVLVPKNKEN-FNCDYVNANWIPSE---------GPRKYIAAQGPVPA
.   .....|. . | ....         ..... .|...|||..|..|| ||| .   ...  ..||.||...             .||.||.||| | 
llllldfltgllkefekllsvtvfllgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydlkrkfIatqgPlpe

SLVSFWQMVVEHDARLIVMLTNEIEGGKLKCHRYWPDDNMAKASHPqpvkkvkigtYIVSFEGEESFPTYVHRKFKLYL--ESGEARDVSQMAYTAWPDH
.. .||.|. |.. ..|||||...| |. ||..||||..  .  ..          . | . .||  . |..|....    ..|| | | .. ||.||||
tvedFwrmlweqgvtvivmltelvelgrekcaqywPdegeeltygn..........ftvtllseehldgytvrtlevtdldgtgesrtvthfhytgwpdh

GVPATTKELLGFRLAVKDQLKR--LNCTPLIHCSAGVGRTGTFIGLDRYIDRVLSKRD---ADVLDIVRDMRRARNFMIQFVYLFLVCLDA
||| ...||| |  .|.. |..   ..  |.|||||||||||||...  .... .       |.|..|. .|. |  ..|    .  . .|
gvppsfeelldfieevrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyea
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 66-349 4.1e-64 211.6 In-house 8-284 (319) alignment 
Range on Protein: 66-349
Range on HMM: 8-284/319.0
QKLRAQIKAHSANNNAGFIETFTSIRDGLGSAATASRSDANQHLNRYSNIVAYDATRVLVPKNKENFNCDYVNANWIPSE-GPRKYIAAQGPVPASLVSF
|.|. ..||. .. . .. . |  .. .     . .  . |.. |||.||.||| ||| ... ..  . ||.||..| .    .|.||.|.|.   .  |
qeLkerlkalastgetllekefkllkeavndtfdsaskeenkkknryqnilaydrtrvvlseldgvegsdyinasfidgyqerekfiatqaPlentiedf

WQMVVEHDARLIVMLTNEIEGGKLKCHRYWPDDNMakashpqpvkkVKIGTYIVSFEGEESFPTYVHRKFKLYLESGEA--RDVSQMAYTAWPDHGVPAT
|.|| |...  .||||.  | .|.|...|||. |.           .. | .||  | ||    |. ||.||   |.|   |.|..  ||.||||.|| .
WrmvWeeessivvmltklveklkvklkkywpeenf...........eeyGrlivtleeeeeledyiirklklnkkssevetRevkhfqyteWpdhdvPek

TKELLGFRLAVKDQLKRLNCTPL-IHCSAGVGRTGTFIGLDRYIDRVLSKRDADVLDIVRDMRRARNFMIQFVYLFLVCLDAMDQLEK
.. || .   ..   .. .  |. .||||||||||||| ||  ..||      ||  .|. .|  ||.|.|    . .. .|. .  .
atslldllkrirksrektqsgPivvhCsaGvGRtGtfivldamlervkeegvlDvfstvsrlRtqRnimvqrpeqYkfiyealleave
0040439 (Phosphotyrosine protein) phosphatases II 101-343 5.9e-63 208.1 In-house 6-241 (249) alignment 
Range on Protein: 101-343
Range on HMM: 6-241/249.0
SRSDANQHLNRYSNIVAYDATRVLVPKNKENFNCDYVNANWIPSE-GPRKYIAAQGPVPASLVSFWQMVVEHDARLIVMLTNEIEGGKLKCHRYWPDDNM
..  .|...|||..|..|| .|| .   .. | .||.||..|.    .|..||.||| | .. .||.|. |.. . |||||.. | |. ||..|||....
allpenkdknrypdilpydhsrvklsilpglflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywplggs

AKAshpqpvkkvkiGTYIVSFEGEESFPTYVHRKFKLYL-ESGEARDVSQMAYTAWPDHGVPATTKELLGFRLAVKDQLKR--LNCTPLIHCSAGVGRTG
 .            |.. | .  .|... |..|...|.  . || | | .. || ||||||| ....|| |  ||.. |..   ..  |.||||||||||
ley...........gdftvtllsvevkddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtG

TFIGLDRYIDRVLSKRDADVLDIVRDMRRARNFMIQFVYLFLVCLDA
|||...  ....  ... |....|...|..|. ..|    .  ...|
tfiaaylmleqlekelgvdleeavkllrsqRpgavqnpeqyrflyea
0042113 (Phosphotyrosine protein) phosphatases II 101-343 2e-62 206.1 In-house 4-238 (245) alignment 
Range on Protein: 101-343
Range on HMM: 4-238/245.0
SRSDANQHLNRYSNIVAYDATRVLVPKNKENFNCDYVNANWIPSEG-PRKYIAAQGPVPASLVSFWQMVVEHDARLIVMLTNEIEGGKLKCHRYWPDDNM
..  .|...||||.|..|| ||| ..  .... .||.||....    ..|.||.||| | ..  ||.|. |.. . |||||.| | |. ||..|||....
allpenkdknrysdilpydhtrvklspdggdldsdyinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywplges

AKAshpqpvkkvkiGTYIVSFEGEESFPTYVHRKFKLYL-ESGEARDVSQMAYTAWPDHGVPATTKELLGFRLAVKDQLK-RLNCTPLIHCSAGVGRTGT
 .            |...| . .||....|..|....    ..| | | .. |. ||||||| ... || |  .|...|.   | . |.|||||||||||
lty...........gdftvtllseehlddytvrtlevtnlgddesrevihyhylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGt

FIGLDRYIDRVLSKRDADVLDIVRDMRRARNFMIQFVYLFLVCLDA
||.... .... . .. .. ..|...|. |  ..|    .  . .|
fiaaylmleqlekelgvsleeavkelrsqRpgavqtpsqyrflyea
Y_phosphatase Protein-tyrosine phosphatase 106-344 9.9e-62 203.8 Pfam-A 1-233 (235) alignment 
Range on Protein: 106-344
Range on HMM: 1-233/235.0
NQHLNRYSNIVAYDATRVLVpkNKENFNCDYVNANWIPSE-GPRKYIAAQGPVPASLVSFWQMVVEHDARLIVMLTNEIEGGKLKCHRYWPddnmakash
|.. |||..|..|| ||| .  .... ..||.|||.. .   ..|.||.|||.. .. .||.||.... ..|||||.. | |. ||..|||         
nkkknRykdilpydktrvkl..kgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwp.........

P---QpvkKVKIGTYIVSFE-GEE-SFPTYVHRKFKLYLESGEA--RDVSQMAYTAWPDHGVPATTKELLGFRLAVKDQLKRLNCTPLIHCSAGVGRTGT
    .   ... |.. |  .  |.     |. ||..|  . .|   | |.|. ||.|||||||...|.|| .  .|. . .  .   ..|||||||||||
eeeee...sltygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgt

FIGLDRYIDRVLSKRDADVLDIVRDMRRARNFMIQFVYLFLVCLDAM
|. ||  .... .... |||.||. .|. |. |.| .  . .. .|.
fvaldilleqleaeeevdvlqivkelRkqRpgmvqsleqYiflykai
Y_phosphatase Protein-tyrosine phosphatase 106-344 9.9e-62 203.8 In-house 1-233 (235) alignment 
Range on Protein: 106-344
Range on HMM: 1-233/235.0
NQHLNRYSNIVAYDATRVLVpkNKENFNCDYVNANWIPSE-GPRKYIAAQGPVPASLVSFWQMVVEHDARLIVMLTNEIEGGKLKCHRYWPddnmakash
|.. |||..|..|| ||| .  .... ..||.|||.. .   ..|.||.|||.. .. .||.||.... ..|||||.. | |. ||..|||         
nkkknRykdilpydktrvkl..kgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwp.........

P---QpvkKVKIGTYIVSFE-GEE-SFPTYVHRKFKLYLESGEA--RDVSQMAYTAWPDHGVPATTKELLGFRLAVKDQLKRLNCTPLIHCSAGVGRTGT
    .   ... |.. |  .  |.     |. ||..|  . .|   | |.|. ||.|||||||...|.|| .  .|. . .  .   ..|||||||||||
eeeee...sltygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgt

FIGLDRYIDRVLSKRDADVLDIVRDMRRARNFMIQFVYLFLVCLDAM
|. ||  .... .... |||.||. .|. |. |.| .  . .. .|.
fvaldilleqleaeeevdvlqivkelRkqRpgmvqsleqYiflykai
subfamily_PTPN3_pd Subfamily PTPN3 93-338 1.4e-60 199.6 In-house 28-265 (280) alignment 
Range on Protein: 93-338
Range on HMM: 28-265/280.0
GLGSAATASRSDANQHLNRYSNIVAYDATRVLVPKNKEnfncDYVNANWIPSEGPR-----KYIAAQGPVPASLVSFWQMVVEHDARLIVMLTNEIEGGK
  | | .|.|  .| . ||| .|..|||||| . ...     ||.|||..  | |      .|||.|||.. .   ||||| |....||||||. .| |.
kpglaisaarkpenlsknryrdilpydatrvklkeset....dyinanyvnmeipstglvnryiatqGPlaktatdfWqmvweqksslivmlttlverGr

LKCHRYWPDDNmakashpqpvKKVKIGTYIVSFEGEESFPTYVHRKFKLYLES-GEARDVSQMAYTAWPDHGVPATTKELLGFRLAVKDQLKRLNCTPLI
 |||.|||. .          .... |.. |  | |..  .|| |.. |  ..  | | . |. |.||||||||  ....| |   |... .  .   ..
vkChqyWPete..........deleygefsvkcekedetksyvlrelvlkdketkeerkilqlqylaWpdhgvPddsadflefvervrklrsgkeePvvv

HCSAGVGRTGTFIGLDRYIDRVLSKRDADVLDIVRDMRRARNFMIQFVYLFL
|||||.|||| .| |.  .  . ....  .||||| ||  |  ..| .  . 
hCsaGigrtGvlilletalalieaaepvypldivrtmrdqramlvqtasqyk
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 70-340 1.4e-59 196.8 In-house 16-282 (298) alignment 
Range on Protein: 70-340
Range on HMM: 16-282/298.0
AQIKAHSANNNAGFIETFTSIRDGLG----SAATASRSDANQHLNRYSNIVAYDATRVLVPKNKENFNCDYVNANWIPS-EGPRKYIAAQGPVPASLVSF
   . . ... .|. . |  .. .         ...|...|.. |||..|.|.| .||.. |.... ..||.|| .. . .|   .||.|.|...... |
klaavkkkkkltgyalefqrlnsvsseieeeekevarkpenkkkNRyadiialdssRvvLekedadeesdYiNAsflhaykgrnafiatqaPltetvedF

WQMVVEHDARLIVMLTNEIEGGKLKCHRYWPDDNMAKASHPQPvkkvkigtyivSFEGEESFPTYVHRKFKLY-LESGEARDVSQMAYTAWPDHGVPATT
|.||.|.|.  ||||||  | .|.|.|.||||.. ..  . .            |   .|.|  .. ||.|.   .. . | | |. .| |||.|||...
WrmvteedigtiVmltnleeldktkyhkywPdegketygeitv...........sllskeefadlivrklkvskkkeekerevrqlhftsWpdkgvpena

KELLGFRLAVKDQLKRLNCTP-LIHCSAGVGRTGTFIGLDRYIDRVLSKRDADVLDIVRDMRRARNFMIQFVYLFLVC
. .|...  |. . ..   .| ...|||||||.|||| .|  ..||  ..  ||...|. .|. |  ..|    .  .
tsvldllrkvrasqqqagnkpvivqCsaGvgRsGtfiaidsvlervkkeqvvDvfqvvkvlRkkrpgavqteeqYvfi
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 67-347 5e-59 194.9 In-house 8-282 (305) alignment 
Range on Protein: 67-347
Range on HMM: 8-282/305.0
KLRAQIKAHSANNNAGFIETFTSIRDGlGSAATASRSDANQHLNRYSNIVAYDATRVLVPKNKENFNCDYVNANWIPS-EGPRKYIAAQGPVPASLVSFW
.| |.|| ...... |. . . |. .  ...    ...||.. ||...|. .|  |. . ..... . ||.||... . ..  |||.||||..  .. ||
dlaayikearvysdkgleaqykslyee.eesidvgkkeankaknrlkeitlldddriiltekeslddsdyinasyvdgykrkkkyivaqgPlkntvadfW

QMVVEHDARLIVMLTNEIEGGKLKCHRYWPDDNMakasHpqpvkKVKIGTYIVSFEGEESFPTYVHRKFKLYL--ESGEARDVSQMAYTAWPDHGVPATT
...||   . |||||. .|||| ||..|||.       .     |...| ..|  . |.... |. ||.|.    |. | | |.|.  | ||||||| ..
rliveekvstivmltklveggkdkCrqYWpeskt....e.....kkefgefsvelksektasdyieRklkisiededkesrtvlqyqltdWPdhGvpqfa

KELLGFRLAVKDQLKRL-NCTPLIHCSAGVGRTGTFIGLDRYIDRVLSKRDADVLDIVRDMRRARNFMIQFVYLFLVCLDAMDQL
  || .   |. . |.  . . |.||||||||||.|| .|  ..|.      || .... .|. |  |.|    .  . ||.|.|
tsllslikrvqkdqkkdkgvpllVhCsagvgRtGvfiavdialerlkkEevvdvfevlkqlRskrmkmvqtldqYvflhdaldel
subfamily_PTPN12_pd Subfamily PTPN12 98-337 1.1e-58 193.4 In-house 32-266 (290) alignment 
Range on Protein: 98-337
Range on HMM: 32-266/290.0
ATASRSDANQHLNRYSNIVAYDATRVLVPKNKENFNCDYVNANWIP-SEGPRKYIAAQGPVPASLVSFWQMVVEHDARLIVMLTNEIEGGKLKCHRYWPD
..|.... |.. ||| .|. || .|| . |..|. . ||.|||.|  .||. .|||||||.|. |  ||.|. |.. ...||. .|.| || ||.||||.
teagekeenvkknrykDilPydksrvelskieeeegsdYinanfikgvegkleyiaaqgPLpktlddfWrmiweknveivvmaCrevelgkkkCerYWpe

DNMakashpqpvKKVKIGTYIVSFEGEESFP-TYVHRKFKLYLEsGEARDVSQMAYTAWPDHGVPATTKELLGFRLAVKDQLKRLNCTPLIHCSAGVGRT
 .          .....|.. |. | |. .   .. | .|.  . .| | | |. ||||||||||...|.|| .  .|..  .. .   ..|||||||||
ege.........eelefgefevtleeekavdddflirtLkveaq.kesrkvyqfhYtaWPDhgvPssaksllelielvrelqesedaPlvvhCsaGvGrt

GTFIGLDrYIDRVLSKRD----ADVLDIVRDMRRARNFMIQFVYLF
|| | .| |. ..| ..      || |.|...|. |. ..|    .
Gtiiaid.yvrellkaekipeeldvfdlvlelrkqraalvqtkeqy
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 105-339 5.1e-58 191.2 In-house 19-255 (270) alignment 
Range on Protein: 105-339
Range on HMM: 19-255/270.0
ANQHLNRYSNIVAYDATRVLVPKNKENFNCDYVNANWIP--SEGPRKYIAAQGPVPASLVSFWQMVVEHDARLIVMLTNEIEGGKLKCHRYWPDdnmaka
 ...|||| .|.   |||| ... .|. .  |.|||...  .. ..|||||.||.|..| |||.|..|. .. |||.|.  | |. || ||||       
rgkklnRyadiLPsPatRvrleeleedsataYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkgrkkCerYWpa......

sHPQPVKKVKIGTYIVSFEGEESFPTYVHRKFKLYlESGEARDVSQMAYTAWPDHGVPATTK------ELLGFRLAVKDQLKRLNCT--PLIHCSAGVGR
 .|.   |.. |.  |  . ||    |. .. .|  |.|| | .    |..||||||| ..       .||    ||. . |.|. .   |.||||||||
.epkekvkledgkikvlalseekeegyiltrlrle.ekgeerrlvHfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkaePllvHcsaGvgR

TGTFIGLDRYIDRVLSKRDADVLDIVRDMRRARNFMIQFVYLFLV
|||.| ||  .  . ... .||| |....|. |  ..| .  .  
tGtlialDiavrlLeetkkvdvlaiieelRkdRmalvqhpeqyef
0037934 (Phosphotyrosine protein) phosphatases II 101-343 8.1e-58 191.2 In-house 5-237 (243) alignment 
Range on Protein: 101-343
Range on HMM: 5-237/243.0
SRSDANQHLNRYSNIVAYDATRVLVpknkENfnCDYVNANWIPSEgPrKYIAAQGPVPASLVS----FWQMVVEHDARLIVMLTNEIEGGKLKCHRYWPd
... .|.. ||||.|..|| .|| .    |.  .||.|||.|.   | ..|| ||| | .. .    ||.|. |.. . |||||...| |..||..||| 
allpenlsknrysdilpydhsrvkl....eg..sdyinanliyvt.p.rliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywp.

dnmakashpqpvKKVKIGTYIVSFEGEESFPTYVHRKFKLYL--ESGEARDVSQMAYTAWPDHGVPATTKELLGFRLAVKDQLKR--------LNCTPLI
             .| .|...| . .||... |..|...|.   .... | | .  |..||||||| ... || |  .|.. ...         . . |.
............gevtygdftvtllseehlddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlV

HCSAGVGRTGTFIGLDRYIDRVlskrDADVLDIVRDMRRARNF-MIQFVYLFLVCLDA
|||||||||||.| ..  ....    . |....|...|. |.. ..|    .  . .|
HCsaGvgRtGtliaaylmllll....gvdleeavkllreqRpgkavqtpsqyrflyea
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 72-342 9.6e-58 190.6 In-house 15-283 (315) alignment 
Range on Protein: 72-342
Range on HMM: 15-283/315.0
IKAHSANNNAGFIETFTSIRDGLGSAATASRSDANQHLNRYSNIVAYDATRVLVPKNKENFNCDYVNANWIPS-EGPRKYIAAQGPVPASLVSFWQMVVE
.  . |. . || . . ||  |       ..   |.. ||| ||.||| .|| .|  . . ..||||||.|.  . .|.||||||| .||.  ||..| |
vaqkkastkngfkqdyesipggqlhpldvakkienkqknryiniiaydksrvqlpllendphsdyvnanfidGynkkrryiaaqgpnvasvkdfwrlvfe

HDARLIVMLTNEIEGGKLKCHRYWPDDnmakashpqpvkKVKIGTYIVSFEGEESFPTYVHRKFKLYLESgEARDVSQMAYTAWPDHGVPATTKELLGFR
.|   |||||| .|| | |. .||||.            ||  | . |.   || .  |  | .    .. . |.| |. ||.||| |||. |  |. . 
edigkivmltnlvegekrkaekywpdk............kviyGkitvtrkseevnteytvrtlsvvfgd.nirevvqlhytswpdmgvpkytiplmnli

LAVKDQLKRLNCTPLIHCSAGVGRTGTFIGLDRYIDRVLSKRDADVLDIVRDMRRARNFMIQFVYLF------L----VCLD
  ||   .   .. ..||||||||||||| ||  .|..  ..  || .... .|. |  |.| .  .      |    || |
rtvkqhhtnsvgaivvhcsaGvGrtGtfitldavldqaeaenaidvynfitgvrqnrikmvqvaeqyqfiydalletfvcgd
subfamily_PTPN6_pd Subfamily PTPN6 70-334 1.8e-57 189.7 In-house 15-283 (306) alignment 
Range on Protein: 70-334
Range on HMM: 15-283/306.0
AQIKAHSANNNAGFIETFTSIRDGLgSAATASR----SDANQHLNRYSNIVAYDATRVLVPkNKENFNCDYVNANWIPSE---GPRKYIAAQGPVPASLV
   | ..  ..||| | | ...    .  . ||       |.. ||| ||. .| ||| .  ...  . ||.||| | .|     ..|||.|| ... . 
elekeeeslekagfeeefeelqqee.akkllsrkegakpenkeknryknilPfDhtrvilk.epsvpgsdyinanyikkevkgsdksyiatqgclettvs

SFWQMVVEHDARLIVMLTNEIEGGKLKCHRYWPDDNMAKAsHpqpvkkvkiGTYIVSFEGEESFPTYVHRKFKLY--LESGEARDVSQMAYTAWPDHGVP
 ||.||.. ..|.|||.|.|.| || || ||||| .. .. .         |.. |.   |.|  .|. |....    ...|.|.| |. ...|||||||
dFWrmvwqensrvivmttkevErgkekCarYWPdeeekee.y.........GkisvtnvseksladYilRelsvskkkkkkeerevfqyhfksWPdhgvp

ATTKELLGFRLAVKDQLKRLN---CTP-LIHCSAGVGRTGTFIGLDRYIDRVLSK---RDADVLDIVRDMRRARNFMIQFV
. .. .| |   |. . ..|.     | ..|||||.||||||| .|  .. . .|    | |. ..|. .|. |. ..|  
kdpgavLdfledvnrkqeeleeaeagpivvhCsaGiGRtGtfiviDillkliekkgldadidiqklvksvreqrsglvqte
subfamily_Ptp69D_pd Subfamily Ptp69D 66-344 8.6e-57 187.6 In-house 7-282 (307) alignment 
Range on Protein: 66-344
Range on HMM: 7-282/307.0
QKLRAQIKAHSANNNAGFIETFTSIR-DGLGSAATASRSDANQHLNRYSNIVAYDATRVLVPKNKENFNCDYVNANWIPSE-GPRKYIAAQGPVPASLVS
..|. ..|..  . . |... . ..        ...|  . |.  ||| .|.|.| ||| ..| . . . ||.||..| .    .|.||||.|| | .  
ddleealksrkrdtdfglakeyekLeareidkstkvsekkenalknRyedikafDktRvkLkkingkedsdYinasfikgykekkkfiaaqdPveatigD

FWQMVVEHDARLIVMLTNEIEGGKLKCHRYWPDDnmakashpqpvKKVKIGTYIVSFEGEESFPTYVHRKFKLYLES------GEARDVSQMAYTAWPDH
||.|. | .  |||||.|. |  . ||..|||..           ..|. |  .| .  ||. . |..|....           . | | |  ||.|.| 
fWRmiaeqevtlivmlsnlteknrkkcakYWpie...........devqygdilvklvseekhsdyiiReldvskkkeesgevedsrkvvqyhytgWkDs

GVPATTKELLGFRLAVKDQlKRLNCTP-LIHCSAGVGRTGTFIGLDRYIDRVLSKRDADVLDIVRDMRRARNFMIQFVYLFLVCLDAM
 || ... || .   |..  ..|| .| ..||||||||.|.|. ||  ....     .|. ..|.|.|. ||...|    .  .  |.
kvPevargllklieqvrel.yklnrsPivvhCsaGvgrsgifvaldsllqqlkaedkvdifetvkdLrsqRnllvqsleqYvflyral
subfamily_PTPN13_pd Subfamily PTPN13 98-344 1.1e-56 187.1 In-house 29-265 (273) alignment 
Range on Protein: 98-344
Range on HMM: 29-265/273.0
ATASRSDANQHLNRYSNIVAYDATRVLVPKNKEnfncdYVNANWIP---SEGPRKYIAAQGPVPASLVSFWQMVVEHDARLIVMLTNEIEGGKLKCHRYW
.. .....|.. ||| |.. ||.||| . ..       |.||..|     .   .|||.|||.| .   ||||| | .|..|.|.|.| |.||.||||||
cevgkkkenkdknryrnvlPydetrvklgdegg.....yinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweqkaeviamvtlekekgkvkchryw

PDDNMakashpqpvKKVKIGT-YIVSFEGEESFPTYVHRKFKLY-LESGEARDVSQMAYTAWPDHGVPATTKELLGFRLAVKdQLKRlNCTP-LIHCSAG
|. .          ||.|.   . |. .. .   ..| |....  .||||.|.|... ...|||||||....||| |   |. .|.. . .| ..|||||
Peskn.........kklkvsnrlevellkvqkldgfvvralavkdsesgesrevahlnfvkwPdhgvPssaaellqfvaevr.rlqt.dagPivvhcsaG

VGRTGTFIGLDRYIDRVLSKRDADVLDIVRDMRRARNFMIQFVYLFLVCLDAM
.||.||.| .|  .. .  ... || .|||..|. |. ..|    .. .  |.
iGrsGtlitidvvlglierdkefdvkeivrklreqrqgvvqtkdqyifvykai
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 101-345 3.6e-55 181.9 In-house 4-243 (250) alignment 
Range on Protein: 101-345
Range on HMM: 4-243/250.0
SRSDANQHLNRYSNIVAYDATRVLVPKNKENFNCDYVNANWIPS-EGPRKYIAAQGPVPASLVSFWQMVVEHDARLIVMLTNEIEGGKLkCHRYWPDDNM
..  .|.. |||..|.|.| .||.. |.| . ..||.|| .. . .. . .||.|||..|... ||.||.|...  ||||||  | .|  .|.||| .. 
akkpqnkeknryadiialdssrvvLekekgdkesdyinasflhgyderkafiatqgPlqatiedfWrmvleeksgtivmLtnLkesekt.yhqywPveka

AkashpqpvkkvKIGTYIVSFEGEESFPTYVHRKFKLYLESGE-ARDVSQMAYTAWPDHGVPATTKELLGFRLAVKDQLKRLNCTPL-IHCSAGVGRTGT
            | |   ||   .| |  |..||.||  .. .  | | |. ...||| |||....  |...  |. . .. . .|. ..|||||||.|.
e...........kyGdvtvsllskeefadytkrklklskakkaderivrqlhfvvWPdkgvPevatavLellkkvqasqqqagnaPvivqCsaGvgrsGa

FIGLDRYIDRVLSKRDADVLDIVRDMRRARNFMIQFVYLFL----VCLDAMD
|| .|  ..|.  ..  || .... .|. |  ...    .     . | |.|
fiaidavlerlkkekvvdvfkvikvlrkdrphavesleqyvfvyeiilkald
subfamily_PTPRA_pd Subfamily PTPRA 66-347 4.1e-54 178.7 In-house 17-294 (330) alignment 
Range on Protein: 66-347
Range on HMM: 17-294/330.0
QKLRAQIKAHSANNNAGFIETFTSIRD-GLGSAATASRSDANQHLNRYSNIVAYDATRVLVPKNKENFNCDYVNANWIPSE-GPRKYIAAQGPVPASLVS
.||  .|. .||..|  | | | ..    . ..  ..  . |.. ||. ||. || .|| ... . . . ||.|| .|       |.||||||   ..  
ekleeeirirsaddnklfreefnalPagpiqatlelaskeenkeknrvvnilPydfsrvilsvkeGveesdyinasfidGykekdkfiaaqGPkeetved

FWQMVVEHDARLIVMLTNEIEGGKLKCHRYWPDDNMakashpqpvkkVKIGTYIVSFEGEESFPTYVHRKFKLY-----LESGEARDVSQMAYTAWPDHG
||.|. |...  |||||.  |  . ||..||||. .           |  |   |. | |.    |  ||| .       .  ..| |.|. .|.||| |
fwrmiweqksativmltelkerkeekcaqywPdeGl...........vtyGnirvevedetvlvdytvrkflvqqlpdatrekksrlvrqfhftswPdvG

VPATTKELLGFRLAVKDQLKRLNCTPLIHCSAGVGRTGTFIGLDRYIDRVLSKRDADVLDIVRDMRRARNFMIQFVYLFLVCLDAMDQL
||.... .| .  .|| . ..   .  .||||||||||||| ||  ..|| ..|  || ..|. .|  |  |.|    .  .  .. . 
vPfepiGmlkllkkvkklnqqsagpivvhcsaGvGrtGtfivldavlervkaerkvdvfefvkrlrlqrpqmvqtdeqyefiykvlley
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 79-334 6.7e-54 177.8 In-house 17-263 (315) alignment 
Range on Protein: 79-334
Range on HMM: 17-263/315.0
NNAGFIETFTSIRDGLGSAATASRSDANQHLNRYSNIVAYDATRVLVPKNKENFNCDYVNANWIPSEGP-RKYIAAQGPVPASLVSFWQMVVEHDARLIV
. | | | |  . |   .  ...| . |.. ||| ||. .| .|| .    .. . ||.||  |.|    . |||.||| .||.  ||.||.....  ||
htalfseefhdlpdPdiyrqrvaretinfkknryknilPldsarvkleviddsPdsdyinasyiksvdddkayiasqgPlkasvddfwrmvlqekvttiv

MLTNEIEGGKLKCHRYWPDDNmakAshpqpvKKVKIGTYIVSFEGEESFPTYVHRKFkLYLESGEARDVSQMAYTAWPDHGVPATTKELLGFRLAVKDQL
|.|.  || |.|| .|||| .   |      . |. |.. |.    |.    |.||.    .| | | |.|  .| |||.||.  |  || .  .|| . 
mvtkkqegdkikcrqywPdrk...a......dsvefGsikvellsleadtdgvarkl.vtrkseesrtvtqfqftewPdkGvdkqtssllklikevkadn

KRLNCTPLIHCSAGVGRTGTFIGLDRYIDRVLSKRDADVLDIVRDMRRARNFMIQFV
.. . . |.|||||||||| .| .|  ....  .|  ||...|. .|. | ...|  
gkkefsllvhcsaGvGrtGvvisidevvaqikrtrsvdvfnfvknlrakrpylvqte
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 83-333 1.1e-53 177.1 In-house 20-261 (515) alignment 
Range on Protein: 83-333
Range on HMM: 20-261/515.0
FIETFTSIRDGLGSAATASRSDANQHLNRYSNIVAYDATRVLVPKNKENFNCDYVNANWIPSEGP-RKYIAAQGPVPASLVSFWQMVVEHDARLIVMLTN
| | |  .        | .. . | . ||| ||. || .|| .   ..| . ||.||  |||    . |||.||| .||.  ||..|....   |.|.|.
fseefhdlpgpniypqtvaqeeinfkknryknilPydsvrvklevindnPhsdyfnasyipsfdndkayiasqgPnkasvddfWrlvlqenvttiamvtk

EIEGGKLKCHRYWPDdnmakashpQPVKKVKIGTYIVSFEGEESFPTYVHRKFKLYLESGeARDVSQMAYTAWPDHGVPATTKELLGFRLAVKDQLKRLN
  || | || .||||         .| . || |.. |.    |.    . ||...  ..  .| | |  .| |||.|||  |. || .  .|| .  ...
lkegdkikcgkyWPd.........kpgdsvkfGsikvelvsleactggikrkltvlkgdd.srtvtqfhfteWPdkGvpkhtssllklikevkadhgqyt

CTPLIHCSAGVGRTGTFIGLDRYIDRVLSKRDADVLDIVRDMRRARNFMIQF
 . .||||||||||| .| .|  . ..   |  ||...|. .|. | ...| 
hpliihcsaGvGrtGvvisidsvvahakttrmvdvfnfvtnirqkrpylvqt
subfamily_PTPN9_pd Subfamily PTPN9 77-343 3.5e-53 175.6 In-house 12-285 (297) alignment 
Range on Protein: 77-343
Range on HMM: 12-285/297.0
ANNNAGFIETFTSIRDGL-GSAATASRSDANQHLNRYSNIVAYDATRVLVPKNKENFNCDYVNANWIPS-EGPRKYIAAQGPVPASLVSFWQMVVEHDAR
.... | .. .. ||.      ..||.. || . |||.... || ||| ..| .|. . ||.|||..   . .. .||.|||..     ||.|| |....
ekgkrGlskeyaeirnepveGtflasklranleknrytdvlcydetrvvlakvdedeasdyinanfvdGykqkkafiatqGplkktvsdfWrmvWeqevl

LIVMLTNEIEGGKLKCHRYWPDDNMAKASHpqpvkkvkiGTYIVSFEGEESFPTYVHRKFKLY-LESGEARDVSQMAYTAWPDHGVPATTKELLGFRLAV
 ||| |  .| |.||| .|||... . |..         | . ||    |.   |..|.....  . .| | |.   ...|||.||| ....|| .. .|
vivmttrvvergrlkcgqyWpleeessaef.........gdlsvsnveveeeedykvrvleiknvkteesrkvthfqflsWPdyGvPssaaslldvlekv

KDQLK------------RLNCTP-LIHCSAGVGRTGTFIGLDRYIDRVLSKRDADVLDIVRDMRRARNFMIQFVYLFLVCLDA
...              ...  | ..|||||.||||||| ||  ..|. ..  .|| . |. .|  | |.||    .  |  |
rekqalavkelgdewkghpsgPPivvhcsaGiGrtGtfitldiclsrleevgtvdvvetvkllrtqrafsiqtpeqyefcyla
subfamily_PTPRG_pd Subfamily PTPRG 69-347 2.7e-51 169.5 In-house 7-290 (563) alignment 
Range on Protein: 69-347
Range on HMM: 7-290/563.0
RAQIKAHSANNNAGFIETFTSIRDGLGSA---ATASRSDANQHLNRYSNIVAYDATRVLVPKN-KENFNCDYVNANWIPS-EGPRKYIAAQGPVPASLVS
   . .  |... || | | ..     |    |..|.   |.. |||.|||||| .|| . .   .. . ||.|||.|   .  ...||.|||..  .  
akhvaslhadgdigfseefealqsetiskdldaehsqkpenkrKnRylnivaydrsRvklsplpgkkkklDYinAnyidGyqkskafiatqgplkdtfdd

FWQMVVEHDARLIVMLTNEIEGGKLKCHRYWPDDNMAKASHPQpVKKVKIGTYIVSfeGEESFpTYVHRKFKLYLESGEARDVSQMAYTAWPDHGVPATT
||.|. |. . .|||.||  | |. ||..||| |.  .  . | |. ..  . ...   .... .  ..| |   .  . . | |  || |||||||  .
FWrmiWeqnvaiivmitnlvergrrkcdvYWPkdesetygalq.vtlieeevlaly..tvrtl.viknlklkkkkqcdteklvrqyhytkWPdhgvPehs

KELLGFrLAVKDQLKRLNCTPL-IHCSAGVGRTGTFIGLDRYIDRVLSKRDADVLDIVRDMRRARNFMIQ----FVYLFLVCLDAMDQL
   | |    ... .. .  |. .|||||||||||.| ||  . .. ..   .|..... .|  |||..|    ...|. . |.|.   
lpvLif.vkkssaankaeaGPivvHcsaGvgrtGtyivldtllkqiqqenavnvfgflkhiraqRnflvqteEqYiflhdalleaiask
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 70-346 2.9e-51 169.1 In-house 9-285 (290) alignment 
Range on Protein: 70-346
Range on HMM: 9-285/290.0
AQIKAHSANNNAGFIETFTSIRDGLGS-AATASRSDANQHLNRYSNIVAYDATRVLVPKNKENFNC--DYVNANWIPS-EGPRKYIAAQGPVPASLVSFW
  .  . |..| || . |...  |  . ..|   .  |..|||..||| ||  |. . .  .. .|  .|.|| .|   .  ..|||.||||.  || ||
efvanghakgnegfrnqfkmldsgesehtvtvgltssnkllnRfanivvyddnritLrpisghkDCtneyinAcyikgykekkqyiatqgpvsntlvdFW

QMVVEHDARLIVMLTNEIEGGKLKCHRYWPDDNMAKaSHPQPVKKvkigtyivsfEGEESFPTYVHRKFKLYLESG--EARDVSQMAYTAWPDHG-VPAT
.......   ||||||.|| || ||. |||| . ..   .  .|             ||.. .|..||...  ..   ... | |   |.|...| |...
kliwqekvtiivmltniieegkvkCqqYWpdsdtka.ygefsikl..........lneetlneyierklevknknsagakqsvtqyqitnwdstgkvtnp

TKELLGFRLAVKDQLKRLNCTPLIHCSAGVGRTGTFIGLDRYIDRVLSKRDADVLDIVRDMRRARNFMIQFVY----LFLVCLDAMDQ
.  || ..  .| | || |   ..|||..|||...|. ..  |... ..   ||..... .|  .  ..| |     .| . | ..|.
qtillvieemyktqrkrgntsivvHCSdtvgrsavfcaaattinkcktegvidvfqvlksqRiqkpgsvqtvqqyqgifqivltylds
subfamily_PTPRK_pd Subfamily PTPRK 71-344 1.8e-50 166.5 In-house 12-273 (314) alignment 
Range on Protein: 71-344
Range on HMM: 12-273/314.0
QIKAHSANNNAGFIETFTSIRDGlgsaATASRSDANQHLNRYSNIVAYDATRVLVPKNKENFNCDYVNANWIPS-EGPRKYIAAQGPVPASLVSFWQMVV
.|.   .... || | . |. .|      |.. | |.. ||. .|.||| .|| .   ... . ||.||..| | . |...|..|||..  .  ||..| 
siallkraegygfkeeyeslfeg....wdaakkdenreknrsgdilaydrsrvflitidgdpssdyinaalidsykrpaafivtqgPlqetvkdfWrlvy

EHDARLIVMLTNEIEGGKLKCHRYWPDDNMAkasHpqpvKKVKIgtYIVSFEGEESfptYVHRKFKLYL---ESGEARDVSQMAYTAWPDHGVPATTKEL
....  |||||. .| |..|| .|||.| .    .    ...|.   .|. | ..    .|.| |...       | | | |. ...||||.||   . |
dencasivmltelvevgrvkClkyWPedtev...y....gdikv..elvetellae...lvvrifrveklargqeeirevrqfqflgWpdhdvPvsatgl

LGFRLAVKDQLKRLNCTPLIHCSAGVGRTGTFIGLDRYIDRVLSKRDADVLDIVRDMRRARNFMIQFVYLFLVCLDAM
|..   || . .  .   ..||||| ||||||| .|  .| .  ..  ||  .|...|  .  |..    .  . |..
lklvrrvkksqeeeaGrivvhCsaGaGrtGtfiaidivldmieregvvdvfnavktlrsrkvnmveteeqykfiydvi
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 71-346 4.3e-50 165.7 In-house 13-286 (325) alignment 
Range on Protein: 71-346
Range on HMM: 13-286/325.0
QIKAHSANNNAGFIETFTSIRDGLGSAATASRSDANQHLNRYSNIVAYDATRVLVPKNKENFNCDYVNANWIPSE-GPRKYIAAQGPVPASLVSFWQMVV
... . |... ||   |  .    | | ...   .|.  ||. |.||.| .|| .   |.. ..||.||... .. .   ..||| | .|..  .|..|.
hvekkkaqdqdgfahefgllpsddgiakkvamkpenkaknrfknvvaldksrvvletkkddpssdyinasylrddkkkdvflaaqaPltatindlWrlvl

EHDARlIVMLTNEIEGGKLKCHRYWPDDnMAKAshpqpvkkVKIGTYIVSFEGEESFPTYVHRKFKLY-LESGEARDVSQMAYTAWPDHGVPATTKELLG
.  .  .|...||...|| .|  |||.. |.|.        .. |.  |..   | .  ||||....   . ||.| | |. . .|.| ||.     |. 
dWrcs.vvvvlneldlgkdrcavywpke.mgks........ktfGglevklrtieeisdyvhrvldvkqvkkGetrsvkqfqlqswddmGvqkrpatlis

FRLAVKDQLKRLNC-----TP-LIHCSAGVGRTGTFIGLDRYIDRVLSKRDADVLDIVRDMRRARNFMIQFVYLFLVCLDAMDQ
.   ||   .|...     || |.||||||||||.|| |   ...|. .   |... |. .|. |  |.. |  . .. .|. .
ilqlvkavservtantkastpilvhcsaGvGrtGvfislysalakvieesrvdifgfvkklrkdrpsmvetvdqyiliyealve
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 72-338 4.9e-50 165.1 In-house 11-270 (287) alignment 
Range on Protein: 72-338
Range on HMM: 11-270/287.0
IKAHSANNNAGFIETFTSIRD--GLGSAATASRSDANQHLNRYSNIVAYDATRVLVPknkeNFNCDYVNANWIPSE-GPRKYIAAQGPVPASLVSFWQMV
..   |..| || . || . .        | . .  |...||...|. .|  |||.     . . ||.|| .| .    ...|.|..|.   .. ||...
vakghakgnegfknqftvleqvtqredevthniasqnkdknRltqilvpdnyrvllk....gehpdyinavfidgykekkafiiaesPmfntarnfWkli

VEHDARLIVMLTNEIEGGKLKCHRYWPDDNmakashpqpvkKVKIGTYIVSFEGEESFPTYVHRKFKLYLES--GEARDVSQMAYTAWPDHG-VPATTKE
 ..    ||||..| |  . .|..|||...            | .| | ...  ||    |. ||...  ..  |. . | |  .|.|...| |.     
ddrnvtaivmlcqekendeevcyqyWpeek...........svvlGeyniellneevnagyierklevknknkagdkqqvkqyqitnWdstgkvtepqti

LLGFRLAVKDQLKRLNCTPLIHCSAGVGRTGTFIGLDRYIDRVLSKRDADVLDIVRDMRRARNFMIQFV--YLFL
|| .   .| | || | . ..|||..|||...|.  .  |...      ||..... .|  .  ..| |  | |.
llvieemyktqrkrgntsivvhCsdtvGrsamfcaaattinkckteGviDvfqvlksqriqkpgsvqtveqykfi
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 106-333 6.2e-50 164.6 In-house 3-224 (237) alignment 
Range on Protein: 106-333
Range on HMM: 3-224/237.0
NQHLNRYSNIVAYDATRVLVPKNKENfnCDYVNANWIPS--EGPRKYIAAQGPVPASLVSFWQMVVEHDARLIVMLTNEIEGGKLKCHRYWPDDNmakas
|.  |||.|||||| .||..  .  .  .||.||... .    |.||||||||. .|   ||||| .    .|||||  ||| .||||.|||. .     
nkiknrygnivaydhsrvvlkgagsg..sdyinatylkgfdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywpstd.....

hpQPVKkvkIGTYIVSFEGEESFPTYVHRKFKLYL--ESGEARDVSQMAYTAWPDHGVPATTKELLGFRLAVKDQLKR-LNCTP-LIHCSAGVGRTGTFI
  ||      | . ||.  .| |  |  | . |    .  | | . |  .|.|||.|||  |  || ||  . .. .   ...| .||||||||||| |.
..qpaa...ygvltvslkkkeefsdytvrslllskrltlkevrlihqyqftswpdrgvpqqtaallrfrkniinrsphvsesgpwiihcsagvgrtgifl

GLDRYIDRVLSKRDADVLDIVRDMRRARNFMIQF
 .|  . .   |.  |. . |  .   | ..|| 
vidamlrqakekkvvdiynyvysieedrpyiiqt
subfamily_PTPN14_pd Subfamily PTPN14 60-334 3.8e-49 162.3 In-house 3-282 (300) alignment 
Range on Protein: 60-334
Range on HMM: 3-282/300.0
LAARHSQKLRAQIKAHSANNNAGFIETFTSIRDGLGSAATASRSDANQHLNRYSNIVAYDATRVLVPKNKENfNCDYVNANWIPS---EGPRKYIAAQGP
 |.|...  ||.|  .  ..   | |     .  . .  .... . |.. ||. ... |. .|| .  .||| . .|.||  |        |.||.||||
eatratkdkrakilekkleegkvfteyeripkkredallstaklpenaeknrfkdvlPyednrvelsptken.stgyinassikvsvggkersyivaqgP

VPASLVSFWQMVVEHDARLIVMLTNEIEGGKLKCHRYWPDDNMaKAshpqpvKKVKIGTYIVSFEGEESFPTYVHRKFKL-YLESGEARDVSQMAYTAWP
..  .  ||||| |.. .||||||.|.|.|| |...|.|...  |.      |.|. | . |. .  |. .... ...|| .| |.| |.|  . || ||
leltvqdfWqmvWeqgvqlivmlteeeedgkeksfkyfPkles.kk......ktvefgkfkvttkfsedsdsvittglklkhlpskeertvwhlqytDWp

DHGVPATTKELLGFRLAVKDQLKR---------LNCTPLIHCSAGVGRTGTFIGLDRYIDRVLSKRDADVLDIVRDMRRARNFMIQFV
|||||   |. | .   |.   ..          .   |.||||||||||  |  |  |  .   .. |.  ... .|. | ...| .
dhgvPeDvkgflsyLeevqsvrrktnseveskeskPPvlvhCsaGvGrtGvlilsdlliatlehneeidikkvlarLreqrmllvqtl
subfamily_PTPN23_pd Subfamily PTPN23 104-353 8.5e-49 160.9 In-house 41-286 (288) alignment 
Range on Protein: 104-353
Range on HMM: 41-286/288.0
DANQHLNRYSNIVAYDATRVLVPKNKEnfncDYVNANWIPSEGP--RKYIAAQGPVPASLVSFWQMVVEHDARLIVMLTNEIEGGKLKCHRYWPDDNMAK
  . . ||. .|. || .|| . ..|.    ||.|| .. .  |   ..||.|.| . .|  ||.||.|  ...||||... | || |..|||| |. . 
klyseknrsrdilPyDhnRvklrgskD....DYinAsfvkdlspgcPdfiatqaPlqstlnDFWlmvyeqkssviVmllskeelgkpkvdrYwPedkget

ASHPQpvkkvkigtYIVSFEGEESFPTYVHRKFKLYL-ESGEARDVSQMAYTAWPDHGVPATTKELLGFRLAVKD---QLKRLNCTPLI-HCSAGVGRTG
 ....         . |. . ... .|.|.|..||   .. . ..|| . .|.||..||||. ..|| |  .|..   . .|   |||. ||||||||||
vkfgd.........lsvtlksvretethvervlkletldadavksvshlqltsWpelGvPasPetllqfldevesayeavqrksktPlvvhCsaGvgRtg

TFIGLDRYIDRVlSKRD--ADVLDIVRDMRRARNFMIQFVYLFLVCLDAM-DQLEKLLDK
.|  .   .  . .|..  .|....|. .|. | ||.| .  .  ...|.  . .. |||
vfalvyaavrel.ekgnglldiiqvvsrlreqRrfmvqekeqlkfsyeavleaarrvldk
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 106-333 4.3e-48 158.8 In-house 28-253 (274) alignment 
Range on Protein: 106-333
Range on HMM: 28-253/274.0
NQHLNRYSNIVAYDATRVLV-PKNKENFNCDYVNANWI--PSEGPRKYIAAQGPVPASLVSFWQMVVEHDARLIVMLTNEIEGGKLKCHRYWPDDNMAKA
.|. ||| .|.  . .|||. ... |. . .|.|||.|  ..|  . |.|.|||.|  .  ||.|. ......|||||.  |  . ||..|.||.. .. 
sqtknryktilPnensrvllesessededssyinanyikGydeeskayvatqGPlpntvadfWrmiyqeevqvivmltklkeaneqkCavyfPdaedyei

SHP-QPVKkvkigtyiVSFEGEESFPTYVHRKFKLYLESGeARDVSQMAYTAWPDHGVPATTKELLGFRLAVKDQLKRLNCT---PLIHCSAGVGRTGTF
|.  . |.        . .|.  .   |  ||. |   .   |.|  . ||.|||| .|  ...|| . | |... .. |      ..|||||.|||| |
serygdve........ikvekiverndysvrklvlkyler.ersvkhywytdWPdhksPddantlldlvleveesreeenaklapvvvhCsaGiGrtGcf

IGLDRYIDRVLSKRDADVLDIVRDMRRARNFMIQF
|. .  . ..  .   ||| || ..|  |  |.| 
iaisiavrqlreeivvdvlkivcnlrldrGGmvqt
subfamily_PTPN1_pd Subfamily PTPN1 97-332 1.3e-47 156.9 In-house 23-255 (290) alignment 
Range on Protein: 97-332
Range on HMM: 23-255/290.0
AATASRSDANQHLNRYSNIVAYDATRVLVPKNkENfncDYVNANWIPSE-GPRKYIAAQGPVPASLVSFWQMVVEHDARLIVMLTNEIEGGKLKCHRYWP
 ..... ..|. |||| ..  || .|. . .. .|   ||.||. .  |   |.|| .|||.|     ||||| |.... .||| . .| ...||..|||
ptreaklpenrnlnryrdvspydhsriklera.dn...dyinaslveleeakrsyiltqGPlpntvdhfWqmvWeqkskavvmlnkvvekeqikcaqywP

DDNMakashpqpVKK--VKIGTYIVSFEGEESFPTYVHRKFKLY-LESGEARDVSQMAYTAWPDHGVPATTKELLGFRLAVKD--QLKRLNCTPLIHCSA
 ..         .|.  ..  .. | .  ||.  .|. |...|  |.. |.|..... ||.||| ||| .   .| |   |..   |..    ..|||||
qgee........ekellledtklkvkliseerksyytvrllelenlktqetreilhfhyttwpdfgvpespaaflkflfkvresGslssdvGpavihcsa

GVGRTGTFIGLDRYIDRVLSKRD---ADVLDIVRDMRRARNFMIQ
|.||.|||. .|  . ..  | |    |. . . ..|. |  .||
GiGrsGtfclvdtclvliekkddlssvdikkvllelrkyrlGliq
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 101-344 8.2e-47 154.3 In-house 33-273 (287) alignment 
Range on Protein: 101-344
Range on HMM: 33-273/287.0
SRSDANQHLNRYSNIVAYDATRVLVPKNKeNFNCDYVNANWIPS-EGPRKYIAAQGPVPASLVSFWQMVVEHDARLIVMLTNEIEGGKLKCHRYWPDDNm
.   |. . |||.... .| ||||. ..  ..  ||.|||...| .   ..||||||..|.. .||..|.|. .  ....| |.| ..|||..|||. . 
aeelaavkknryadvlPiddtrvllsaeg.elGsdyinanyvasytddeafiaaqgPiaatvrdfwravletrsasvitmtreveearlkcykywPere.

akashpQPvkkVKIGTY-IVSFEGEESFPTYVHRKFKLY-LESGEARDVSQMAYTAWPDHGVPATTKELLGFRLAVKDQL--KRLN---CTPLIHCSAGV
      .|   ...| | .| .. .   | |  | ..|  ||. ||| | |. . .|||.... |.  |. | | ||...  .|       ...|...|.
......vP...mrvGGysvvlldydikePeygvralrlidletrearvvkqldllswPdkvlaPtavglirfvldvkqhielardasevGPlvvhddvGi

GRTGTFIGLDRYIDRVLSKRDADVLDIVRDMRRARNFMIQFVYLFLVCLDAM
||.|... .   ..| ..    ||  .|  .|  |. ..| |  . .  .|.
GrsGillatlvlvsrledlGrvdvaavvirlreyraalvqavvqlrllyeal
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 95-345 1e-46 154.8 In-house 50-288 (319) alignment 
Range on Protein: 95-345
Range on HMM: 50-288/319.0
GSAATASRSDANQHLNRYSNIVAYDATRVLVPKNKENFNCDYVNANWIPS-EGPRKYIAAQGPVPASLVSFWQMVVEHDARLIVMLTneieggKLKCHRY
..  | .  | |.  ||. ||.|.| ..| . .       ||.|| ..     . |||||||| . .|  ||.|. |...  ||.||      | || .|
ladqtfanldqnkdknriinilafdknvvklerliGeefsdyinasfvtGyqrkdkyiaaqGPldntladfWrmiweyncstivllt......kdkcsqy

WPDDNMAKASHpqpvKKVKIGtyIVSfEGEEsfptYVHRKFKLYL--ESGEARDVSQMAYTAWPDHGVPATTKELLGFRLAVKDQLKRLN--CTPLIHCS
|| .   |  .     |||.    |  | .|    || |...|    .  . |.. |  .  |||.|||  . .|. .   |.   .. |     ..|||
wplkivikeer....fkvkvd..sve.etae....yvvrdielsedgkekdirkitqfhflGwpdvGvpdypsdlmrlvkkvrhltskenhranivvhcs

AGVGRTGTFIGLDRYIDRVLSKRDADVLDIVRDMRRARNFMIQFVYLFLVCLDAMD
|||||||..| ||  .||.  ..  || ..|||.|. || ..| .  .  .  |. 
aGvGrtGvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysall
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 96-334 3.6e-46 152.7 In-house 41-270 (297) alignment 
Range on Protein: 96-334
Range on HMM: 41-270/297.0
SAATASRSDANQHLNRYSNIVAYDATRVLVPKNKENFNCDYVNANWIPSEGPrKYIAAQGPVPASLVSFWQMVVEHDARLIVMLTNEIEGGKlKCHRYWP
 ..| ..   | . .||.||. ||  || .    .. . ||||| ....    ..|. | | .|..  ||.||.....  ||||... |. | || |||.
qpqtvaekkvnfeksRYkniLPydssRvkLaivnddpdsDyvnasfvkgnkh.rlittqmPmkatvadfWamvldeqvstivmlnddnerdk.kcaryWs

DDNMAKashpqpvkkvkIGTYIVSFEGEESFPTYVHRKFKLYLESG-EARDVSQMAYTAWPDHGVPA--TTKELLGFRLAVKDQLKRLNCTPL-IHCSAG
|. ...            |.  |  .  ..   ...|....  ..    | | |  .. |||. |.   ... || .   |... .  . .|| .||.||
dkgvtt...........fGdvsvvllsvsereGfikrelevtkgkakarrvvkqyqfveWPdkaverkdsassllklisevrkdfsqnaegPllvhclaG

VGRTGTFIGLDRYIDRVLSKRDADVLDIVRDMRRARNFMIQFV
||||| .. .|  . ..  . . |....|. .|. | ...|  
vGrtgvlltidsvvaeakrekevdifglvkklrqerpylvqtk
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 96-345 4.9e-46 152.5 In-house 15-252 (284) alignment 
Range on Protein: 96-345
Range on HMM: 15-252/284.0
SAATASRSDANQHLNRYSNIVAYDATRVLVPKNKENFNCDYVNANWIPS-EGPRKYIAAQGPVPASLVSFWQMVVEHDARLIVMLTneieggKLKCHRYW
.  | .  | |.  ||. .|.|.| ..| . .   .   ||.|| .|     . ||||.||| . .|  ||.|. |...  ||.||      | || .||
tdqtfanldqnkdknrighilafdknvvklerliGeefsdyinasfitGyqrkdkyiatqGPldntladfWrmiweyncstivllt......kdkcsqyw

PDDNMAKASHpqpvKKVKIGtyIVSfEGEEsfptYVHRKFKLYL--ESGEARDVSQMAYTAWPDHGVPATTKELLGFRLAVKDQLKRLN--CTPLIHCSA
| .   |  .     |||.    |. | ||    || |...|    .  . |.. |. .  |||.|||  . .|. .   |.   .. |   . ..||||
plkivikeer....fkvkvd..sve.esee....yvvrdielsedgkekdirkirqfhflgwpdvgvpdypsdlmrlvkkvrhltskenhranivvhcsa

GVGRTGTFIGLDRYIDRVLSKRDADVLDIVRDMRRARNFMIQFVYLFLVCLDAMD
||||||..| ||  .||.  ..  || ..|||.|. || ..| .  .  .  |. 
gvgrtgvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysall
subfamily_PTPRN_pd Subfamily PTPRN 97-343 1.8e-45 150.0 In-house 47-287 (297) alignment 
Range on Protein: 97-343
Range on HMM: 47-287/297.0
AATASRSDANQHLNRYSNIVAYDATRVLVPKNKENFNCDYVNANWIPSEGPRK--YIAAQGPVPASLVSFWQMVVEHDARLIVMLTNEIEGGKLKCHRYW
........ | . ||......|| .|| . .. .. . ||.||  |  . ||.  |||.|||..... .||||| |. . .||.||.  | |  .|.|||
tkevakaeknvkknrskavlpydhsrvklkeeasaeksdyinasaildhdprapayiatqgplastvadfwqmvweqGvvvivnltrleeegvkqckryw

PDDNmAKASHPQPVKKVKigTYIVSfegEesfpTYVHRKFKL-YLESGEARDVSQMAYTAWPDHGVPATTKELLGFRLAVKDQLKRLNCTPLIHCSAGVG
||.  ..  |   |. |    .| .   .     |. | | |  |.. |.| |.|. . .||..||||..| || ||  |    .   |. ..|||.|.|
pdeG.sevyhiyevhlvs..ehiwc...d....dylvrsfylknlqtsetrtvtqfhflswpeegvPasaksllefrrkvnksyrGrscpivvhcsdGaG

RTGTFIGLDRYIDRVLS-KRDADVLDIVRDMRRARNFMIQFVYLFLVCLDA
|||..| .|  ..|.|   .. |.   .  .|  |. ...    | ..| |
rtGvyilidlvlnrllkGvkeidiaatlehlrdqrpglvktkdqfefalta
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 102-339 4.2e-43 142.2 In-house 3-235 (239) alignment 
Range on Protein: 102-339
Range on HMM: 3-235/239.0
RSDANQHLNRYSNIVAYDATRVLVPKNKENFNCDYVNANWIPS--EGPRKYIAAQGPVPASLVSFWQMVVEHDARLIVMLTNEIEGGKLKCHRYWPDDNm
.   |.  |||.|||.|| .||.. |  ..   ||.||...      |. |||.|| | .|   ||.|. .    .|||||  ||| | |||.||||   
kkrvnkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdst.

akaShpqpvkkvKIGTYIVSFEGEESFPTYVHRKFKLY-LESGEARDVSQMAYTAWPDHGVPATTKELLGFRLAV-KDQLKRlNCTPLIHCSAGVGRTGT
   |        |     |..   | |  |. | | .  .   | | | |  .| |||.|||  .  .||.|  . || |       .|||||||||||.
...s........kycnlrvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrkitkdslpg.arpwvihcsagvgrtga

FIGLDRYIDRVLSKRDADVLDIVRDMRRARNFMIQ----FVYLFLV
|. .|  . .   ..  |... |. .|  | .|.|    .|...| 
flvidamlrqakkqktvdifnyvkairedrphmvqtseqyvfihla
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 101-334 5e-43 142.0 In-house 3-227 (239) alignment 
Range on Protein: 101-334
Range on HMM: 3-227/239.0
SRSDANQHLNRYSNIVAYDATRVLVPKNKENFNCDYVNANWIPS--EGPRKYIAAQGPVPASLVSFWQMVVEHDARLIVMLTNEIEGGKLKCHRYWPDDN
..   |.  |||.|||.|| .||.. |  ..   ||.||...      |. |||.|| | .|   ||.|. .    .|||||  ||| | |||.||||  
akkrvnkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdst

makaShpqpvkkvKIGTYIVSFEGEESFPTYVHRKFKLY-LESGEARDVSQMAYTAWPDHGVPATTKELLGFRLAV-KDQLKRlNCTPLIHCSAGVGRTG
    |        |     |..   | |  |. | | .  .   | | | |  .| |||.|||  .  .||.|  . || |       .|||||||||||
....s........kycnlrvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrkitkdslpg.arpwvihcsagvgrtg

TFIGLDRYIDRVLSKRDADVLDIVRDMRRARNFMIQFV
.|. .|  . .   ..  |... |. .|  | .|.|  
aflvidamlrqakkqktvdifnyvkairedrphmvqts
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 77-336 4.2e-41 135.6 In-house 14-224 (392) alignment 
Range on Protein: 77-336
Range on HMM: 14-224/392.0
AN--NNAGFIETFTSIRDGLGSAATASRSDANQHLNRYSNIVAYDATRVLVPKNKENFNCDYVNANWIPSEGP-RKYIAAQGPVPASLVSFWQMVVEHDA
 .   .| |.| |  . .   .  |... . |.. ||| ||. ||..|| .    .  . ||.|| .|||    . |||.||| .|||  ||.|| ....
eknrhsalffeefhdlpgpdiypqtvaqkeinlkknryknilpydsarvkleviddipdsdylnasyipsfdnekayiasqgpnaaslddfwrmvfqenv

RLIVMLTNEIEGGklkchrywpddnmakashpqpvkkvkigtyivsfegeesfptyvhrkfklylESGEARDVSQMAYTAWPDHGVPATTKELLGFRLAV
  |.|.|.  ||                                                        .|| |.|  .| |||..||  |  || |   |
ttiamvtklkegd....................................................kgddartvaqfhftewPdkdvpkhtssllkfikev

KDQLKRLNCTPLIHCSAGVGRTGTFIGLDRYIDRVLSKRDADVLDIVRDMRRARNFMIQFVYL
| .  .     .|||||||||||  | .|  . .    |  ||...| ..|| | .|.|    
kadfGqythpliihcsagvgrtgvvisidsvvahakktrmvdvfnfvtnirrkrpymvqtkeq
0041856 (Phosphotyrosine protein) phosphatases II 106-340 5e-40 132.4 In-house 1-163 (182) alignment 
Range on Protein: 106-340
Range on HMM: 1-163/182.0
NQHLNRYSNIVAYDATRvlvpknkenfNCDYVNANWIPSEGPR-KYIAAQGPVPASLVSFWQMVVEHDARLIVMLTneieggklkCHRYWPddnmakash
|...||||.|. || .|          ..||.|||.. .  |  ..||.||| . .. .|..|. |.. ..||.||         ...|||         
nldknrysdilpydhsr..........dldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt.........eelywp.........

pqpvkkvkigtyivsfegeesfptyvhrkfklyleSGEARDVSQMAYTAWPDHGVPAtTKELLGFRLAVKDqlkrLNCTPLIHCSAGVGRTGTFIGLDRY
                                   . . | . |  |. |||||||  . ||| |  .|..     ... |.|||||||||||.....  
...................................ellerlgiqylylpwpDhgvpd.ldelldfieevle....eggpvlVHCsaGvgRtgtlvaaylm

IDRvlskrDADVLDIVRDMRRARNFMIQFVYLFLVC
. .     . .. ..|. .|..|. |..    . ..
kkl.....gvsleeavklvrsrRpgmvitpnqyffl
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 98-365 8.3e-40 131.7 In-house 33-297 (307) alignment 
Range on Protein: 98-365
Range on HMM: 33-297/307.0
ATASRSDANQHLNRYSNIVAYDATRVLVpkNKENFNCDYVNANWIP-SEGPRKYIAAQGPVPASLVSFWQMVVEHDARLIVMLTNEIEGGKLKCHRYWPD
 |.   .||.. |||... . | .|..|  . .    ||. ||..  .  |.|.|.||||  ..  ||| |.....   ..|| . || .|.||..||| 
vtveafsantdknryqdvkcqdkgrivv..kfdglasdyihanylgiaikpkkficaqgplentqysfwamaiqekvesvimlckvielakikceqywpl

DNMAKASHPQPVKKVKIGTYIVS-FEGEESFPTYVhrKFKLYLeSGEARDVSQMAYTAWPDHGVPATTKELLGFRLAVKDQLKRLnctpLIHCSAGVGRT
..  |  . .  . . .    .  .  .| .      ..|.   ....| .... .. |||.||| .    . .  ||. .   .    ..||||||||.
eegqklvfgeapntisvanlgakklapdedlinvt..tlkvdw.aqksrtiqhlqwenwpdrgvpqinltainlleavrydtnpv....vvhcsaGvGrs

GTFIGLDRYIDRVLSKRD-ADVLDIVRDMRRARNFMIQ----FVYLFLVCLDAMdqLEKLLDKYLAL-ATKSEEEQ
|| ...    |....  .  |. ..|...|  |.. ||    ..||  | |. .  ||.  . |  |  ||  ||.
GtivaislvqdkmiaGinckdmkklveelrsqrhyaiqteaqylylhrvlleyf..lelyketyeellltknyeek
subfamily_ptpA1_pd Subfamily ptpA1 85-318 3.5e-39 129.7 In-house 25-269 (418) alignment 
Range on Protein: 85-318
Range on HMM: 25-269/418.0
ETFTSIRDGLGSAATAS-RSDANQHLNRYSNIVAYDATRVLVPKNKENFNCDYVNANWIPSEGPRKYIAAQGPVPASLVSFWQMVVEHDARLIVMLTNEI
| |  . . .| . |.      |   |||.||.  . ||| . | ...   ||.|||.|    |...|..|||.| ..  ||.|| |  .|.||||. | 
eefrlleesvgpsetsegdkkhntsknrytnilpvnhtrvqlkkiqdkegsdyinanyidgaypkqfictqgplpntiadfwrmvwenrcriivmlsres

EGGKLKCHRYWPDDNMAKASHPQPVKKVKIGTYIVSFEGEESFP--TYVHRKFKLYLEsGEARDVSQMAYTAWPDHGVPATTKELLGFRLAVKD---QLK
|  ..|| ||||..   .        .  .||| | .      |    . |. .| .| ||.||..|  |  |||| .|  |. .  .  .. .   |. 
encrikcdrywpeqiggeqfsiygngnevfgtysvelveviqdpereiitrnirltfe.getrditqyqyegwpdhnipdhtqpfrqllhsitnrqnqii

---RLNCTPLIHCSAGVGRTGTFIG---LDRYIDRVLSKRDADVLD
     |   ..||||||||||||     . . .|. . . ||  .|
pssdrnvpiivhcsagvgrtgtfctavimmkkldhyfkqldatpid
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 76-389 1.2e-38 127.7 In-house 15-316 (439) alignment 
Range on Protein: 76-389
Range on HMM: 15-316/439.0
SANNNAGFIETFTSIRDGLGS---AATASRSDANQHLNRYSNIVAYDATRVLVPKNKENFNCDYVNANWIPS-EGPRKYIAAQGPVPASLVSFWQMVVEH
  |..  | | | .|          |.    . .|  ||| ...|.| ||| . .        |.|||.|     .. |||.|||   .  .||..|.|.
dknkqeifkeifekinstspdyaciaslaaqeydqtknrykdvgafdhtrvtlqeipgvphshyinanyikGyyddklyiatqgpkkettddfwrlviek

DARLIVMLTNEIEGGKlkchrYWPDDNmakashpqpvkKVKIGTYIVSFEGEESFPTYVHRKFKLYLESG---EARDVSQMAYTAWPDHGVPATTKELLG
 .  |||||| .|  |     ||| |.           .|  |  .|  . .  .| || | ||.. |       | | |. |.||||. ||| .  .| 
ktvtivmltnlvesyk.....ywpsda...........evcygdiavrvdrnielpnyvirgfkvfnerdttekertvlqfhyiawpdknvpaqashvld

FRLAVKDQLKRLNCTPL-IHCSAGVGRTGTFIGLDRYIDRVLSKRDADVLDIVRDMRRARNFMIQFVYLFLVCLDAMdqLEKLldKYLALATKSEEEQQE
|  |..    . .. |. .||||||||||| | ||  .... ..   |.  ||. .|. |. |.| .  ...  .|.  || .  .| ..|.  .| ..|
flrainsandkeeygpvvvhcsagvGrtGtiialdialeqlklenkvdikgivkvlrkqrkqmvqalcqyvfiynav..ledi..vyGdiavtidefkke

EELAALTQELVATEDEAVATIK
 .   .|...   ..|  ...|
fnagfstrdisifneedssllk
0051429 (Phosphotyrosine protein) phosphatases II 135-347 2.2e-38 127.8 In-house 5-224 (272) alignment 
Range on Protein: 135-347
Range on HMM: 5-224/272.0
DYVNANWIPSEGP----RKYIAAQGPVPASLVSFWQMvVEHDARLIVMLTNEIEGGKLKCHRYWPDDNMAKASHPQP-VKKVKIGTYIVSFEGEESFPTY
.|.||....  |     .......|| |..  .||..  |.. . ||.|..| | |.|||.||||. .    . .   .  . .| . | .  || .. |
gyiNardvggygrvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseellldy

VHRKFKLYLE--SGEARDVSQMAYTAWPDHGVPATTkeLLGFRLAVKDqlkrlNCTPLIHCSAGVGRTGTFIGLDRYIDRVLSKRDAD--------VLDI
..|.. |.|.   |||| | .. ||.|||||||  .  || .  .. |     .   |.|||||..||||.. |.. . .|     .|        ....
ilrellltlllsagearevmhlhytdwpdhgvpqea..llellellld.....ggpvlvHCsaGkdRTGtvvallllllgvsletivddYlltnlyleea

VRDMRRARNFMIQFVYLFLVCLDAMDQL
|. .|..|  ..|    .| ...|. .|
veelraqrpgavqteeqylflyeallel
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 74-347 2.9e-38 126.3 In-house 8-292 (301) alignment 
Range on Protein: 74-347
Range on HMM: 8-292/301.0
AHSANNNAGFIETFTSIRDGLGSAATASRSDANQHLNRYSNIVAYDATRVLVPKNKE--NFNCDYVNANWIPSE-GPRKYIAAQGPVPASLVSFWQMVVE
 . |... .| | ......|    .| . |..|..|||. ||. ||  |... ....    . .|.||..| .    .|.||||||.   || ||.....
hvaakhsnkfeeqykelkegedksctvglseenkalnrfknitvyddnriilkpkpnldlcqreyinasyidgysekkkfiaaqgpmkktlvdfWrliwq

HDARLIVMLTNEIEGGKLKCHRYWPDDNMAKASHpQPVKKVK-----IGTYIVS-F--E-GEESFPTYVHRKFKLYLESgEARDVSQMAYTAWPDHGV-P
.    |||.||. || | ||..|||. .. . .   |..        .  ...  .     . |  .|..||||   .  ...|| |.  | ||..|| .
ekpvsivmvtnlkegtkskceqywpnseaeseef.gpftvtlvneqvyPdfvirqlnvkiqdgsnngyierkfkvksdk.sswdvlqlqvtdWpqdGvvr

ATTKELLGFRLAVKDQLKRLNCTPLIHCSAGVGRTGTFIGLDRYIDRVLSKRDADVLDIVRDMRRARNFMIQFVYLFLVCLDAMDQL
     |      .. | |      ..|||..|.|.|... ..  .. . .    || .... .|| .  ...    .    |..|. 
eprtvLqviddvihrqqkigggpvvVHCSdtVsrsGvYcsvsiglEQckaegVVdvfqvtkavrrskpgaVtTLeqytsiydvidmy
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 96-344 4.5e-38 125.8 In-house 23-291 (297) alignment 
Range on Protein: 96-344
Range on HMM: 23-291/297.0
SAATASRSDANQHLNRYSNIVAYDATRVLVPKNKenFNCDYVNANWI--PS-EGPRKYIAAQGPVPASLVSFWQMVVEHDARLIVMLTNEIEGGKLKCHR
 . .... ..  . ||| .|.|.| ||| . .     . ||.||...  |  | . ||| ||||. |..  ||..|.|.| | |||...  |.|. ||  
esfssakrnsslrknryrdilatddtrvkllrvi..terdyinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmvaklqedGrdkcap

YWPDDNMAKASHPQPVkkvkiGTYiVSFEGEEsFPTYVHRKFKLYLEsGEARDVSQMAYTAWPDHGVPATTKELLGF-------------RLAVKD----
|||. .  .   .. |       . .|   .| | . .  ...|.    | | |  . . .|||||||.  ..|  |              ||. .    
ywpsvvqerlkagdvv.....vef.lsstsde.fdrviltelqliyr.sesrvvrhvqflswpdhGvpsdledlvrfqaqvcscciavpmmlalvemfta

----QLKRLN------CTPLIHCSAGVGRTGTFIGLDRYIDRVLSKRDADVLDIVRDMRRARNFMIQFVYLFLVCLDAM
    ||. |.         |.||||||||.|  .  |  ....  ||  ||  |.. .|  |  ..| .  | .. ||.
mvflqleslraemprnayllvhcsaGvGrsGvvvlsdvilaklrkkripdvaailsilreqrarlvqtleqfellydav
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 77-334 1.1e-36 121.2 In-house 5-252 (283) alignment 
Range on Protein: 77-334
Range on HMM: 5-252/283.0
ANNNAGFIETFTSIRDGLgSAATASRSDANQHLNRYSNIVAYDATRVLVPKNKEnfncDYVNANWIP----SEGPRKYIAAQGPVPASLVSFWQMVVEHD
.|||  | |..  .       |. . .| |.. ||. .||..|  || .  . .    ||.|| .||     .  .|||.||.|.    | ||.|| ...
vnnnklfrevlkrlsvpd.ldadiasadenkrknrnqeivpadqwrvelksesr....dyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfdek

ARLIVMLTNEIEGGKLKCHRYWPDDNmakaShpqpvkkVKIGTYIVSFEGEESFPTYVHRKFKLYLESGEAR--DVSQMAYTAWPDHGVPATTKELLGFR
.  |||||.  |. . || .||| .     |       .. | . |. . | .  ... ... |  .|       ..   .  | . |  |    |. | 
itaivmltklqedlrikCsqyWPkrG....s.......edyGeftvtlrkettsnsfiikelllrvnssakstlllahyqvidWleygeqaiinslvkfn

LAVKDQLKRLNCTPLIHCSAGVGRTGTFIGLDRYIDRVLSKRDADVLDIVRDMRRARNFMIQFV
. .  | .  .   ..|||.|.|||..||..   .. .|..   ||  .|. ||  |  ..|  
kvislqteskkgPivvhCstgiGrtavfiaasasvkdaltesvvdvfavvkimreqrmmavqtl
0036282 (Phosphotyrosine protein) phosphatases II 135-333 2.2e-35 117.3 In-house 3-155 (174) alignment 
Range on Protein: 135-333
Range on HMM: 3-155/174.0
DYVNANW-----IPSegprKYIAAQGPVPaslvsFWQMVVEHDARLIVMLTNEIEGGKLKCHRYWPDdnmakashpqpvkkvkigtyivsfegeesfpty
|| ||..     |..    ..|| ||| .     ||.|. |.. . .|||..|.| |. ||..|||.                                 
dyinaspldlsyitp....rliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe.................................

vhrkfklyLESGEARDVSQMAYTAWPDHGVPATTKeLLGFRLAVKDQLKR-LNCTPLIHCSAGVGRTGTFIGLDRYIDRVLsKRDADVLDIVRDMRRARN
        | . . | . |  |. ||||||| ... || |  .|.. |..  ... |.|||||||||||...... . . |  .  |.||.|| .|. | 
........lredlerlgiqylylpwpDhgvpdlsi.llefvkfveealsedpggpvlVHCsaGvgRtGtlvaaylmlrgll.eslvdaldlvrelRlqrp

FMIQF
 |.| 
gmvqt
subfamily_CG7180_pd Subfamily CG7180 96-344 9.5e-35 114.7 In-house 33-286 (296) alignment 
Range on Protein: 96-344
Range on HMM: 33-286/296.0
SAATASRSDaNQHLNRYSNIVAYDATRVLVPKNKENFNCDYVNANWIPS-EGPRKYIAAQGPVPASLVSFWQMVVEHDARLIVMLTNEIEGGKlKCHRYW
  |.. |.. |.  ||. ..| || .||...| . . . ||.|| .. |   ...||  ..|.  .. .||..| ....  .|.||.. .  | ... ||
dCagglrke.nreknrdvkvvPyDynRvvLekldGeeksdYinavyvdsflkkkeyivteapkketvdefWrlvydeeisavvvLtktfdfak.mypsyw

PDDNmakashpqpvkKVKIGTYIVSFEGEESFPTYVHRKFKLYLE-----------SGEARDVSQMAYTAWPD-HGVPATTKELLGFRLAVKDQLKRL--
| .            | . |  .|    |....  . |.|||. .           . | | | .. .| |.  . ||  |. |. .|  |.   ..   
pnks...........keqygeifveiveekqyanlkirtfkltkkivalteqekqvkaetRivklfqlteWeledkvPlstnalielrrrvrlwrekvde

--NCTP-LIHCSAGVGRTGTFIGLDRYIDRVLSKRDADVLDIVRDMRRARNFMIQFVYLFLVCLDAM
  .  | ....| |..|.| ....|  .. |  .   || . |. .|| |. ... |  .  . | .
dpeegPvvvvssdGasRsGvylaidanlelvekeeevdvFeavktlrrsRpqLvenveeYkyiYdvl
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 102-360 2.8e-34 113.1 In-house 51-303 (305) alignment 
Range on Protein: 102-360
Range on HMM: 51-303/305.0
RSDANQHLNRYSNIVAYDATRVLVPKNKenfNCDYVNANWI--PSEGPRKYIAAQGPVPASLVSFWQMVVEHDARLIVMLTNEIEGGKLKCHRYWPDDNM
 .| ..  |||... . | . |.. |      .||. ||..  |    ...|.||||.  ..  || ||...    |||| . .| ||||| .|||  . 
sadiaitknryqdvpcqdqsavkldkps...psdyihanyvgcpmipekrficaqgpldqtidefwwmviqnkveqivmlcktvelgklkcaqywpaaqg

AKashpqpvKKVKIGTYIVSFEG---EESFPTYVHRKFKLYLESGEARDVSQMAYTAWPDHGVPATTKELLGFRLAVKDQlkrlNCTPLIHCSAGVGRTG
 |       ...| |  .    |    |  .      ..|    ..   | .. .| ||| |||      | .  |..      .   ..|||||.||||
ek.......lelksgivvenvsgskpmerdaeiqitllnltysgdqkmsvrhlqwtewpdrgvppckltslellsairgs....kvpivvhcsagigrtg

TFIGLDRYIDRVLSKRDA-DVLDIVRDMRRARNFMIQF--VYLFLVCLDAMDQLEKLLDKYLALATK
| . ..  ....  ....  . ..|. .|  | | ||    |||.  .     |||  .|| || | 
tivaieyilekiaenkpcppmpelvkalrdqrafsiqndvqylfihrvmlnyflekykekyaallta
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 104-343 9e-34 111.4 In-house 52-278 (290) alignment 
Range on Protein: 104-343
Range on HMM: 52-278/290.0
DANQ--HLNRYSNIVAYDATRVLVpknKENFNCDYVNANWIPSEGPrKYIAAQGPVPASLVSFWQMVVEHDARLIVMLTNEIEGGKLKCHRYWPDDNMak
|.|   . ||| ..|  | |||..   |. .. ||| ||..    .  .| .||.. .. . .|.||.....  |||| . || || ||..|.|. .   
dkntefkknrykdvvcndktrvil...kdGydGdyvhanyvkGlka.mfiltqGalkdtvidiwrmvlqekvaaivmlceliedGkakceqyypekeG..

ashpqpvKKVKIGTYIVSFEGEESFPTYVHRKF--KLYLESGEARDVSQMAYTAWPDHGVPATTKELLGFRlavkDQLKRLNCTPLIHCSAGVGRTGTFI
       . . .| . |    |..  . . .|       .||    .  .   .|||. |. .|  ||         |....    .|||||.||||||.
.......evltfGeitvlcseeddkdaniikktlsvrdkdsGkehklkhlkikswpdksvalstlallrtl....rilrkasGpvvvhcsaGiGrtGtfv

GLDRYIDRVLSKRDADVLDIVRDMRRARNFMIQFVYLFLVCLDA
 ..  .. .|  .. |.||.|| .|..|   .|    .|. ...
aievglqilldGkeldlldlvralrnsrlnsvqvdiqylalvei
0046846 (Phosphotyrosine protein) phosphatases II 129-338 1.6e-33 111.3 In-house 7-163 (176) alignment 
Range on Protein: 129-338
Range on HMM: 7-163/176.0
KENFNCDYVNANWIPSEgprKYIAAQGPVPASLVSFWQMVVEHDARLIVMLTNEIEGGKLKCHRYWPDdnMAKASHpqpvkkvkigtyivsfegeesfpt
 .....||.|||.| .    ..|| |||.| .| .|..|. |.. ...|.||.|.| |.|||..|||.  . |...                        
gldldldyinanlilgs...rpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpe..leklgi........................

yvhrkfklylesgeardvsQMAYTAWPDHGVPATtKELLGFRLAVKDQLKRlNCTPLIHCSAGVGRTGTFIGLDryidRVLSKRDADVLDIVRDMRRARN
                   |  .. |||||||   . || .  .....||. . . |.|||||.|||||.. ..     . .... .|..... .|. | 
...................qylhlpwpDhgvpdl.elllellefirealke.ggpvlVHCsaGigRtgtlvaay....llelekglsveealalvreqRp

-FMIQFVYLFL
 ...|      
lgavqtpeQyr
0049772 (Phosphotyrosine protein) phosphatases II 101-353 2e-33 111.8 In-house 41-285 (314) alignment 
Range on Protein: 101-353
Range on HMM: 41-285/314.0
SRSDANQHLNRYSNIVAYDaTRVLVpKNKENFNCDYVNANWIPSEgpRKYIAAQGPVPASLVSF----------WQMVV--EHDARLIVM----------
..  .|.. ||| .|. .| .|| . .. .....|| ||... .   .|.||.||| .  .|.|          |.||.  ... | |||          
adlflnrdknryldilpad.nrvil.pglpvsgsdyinasyvdgf..lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivmsrdevladel

-----------LTNEIEGGklkchrywpddnmakashpqpvkkvkI----------GtyivsfegeesfptyvhrkFKLYLESGEARDVSQMAYTAWPDH
           |..  ..|                                                           ||  .   | . .  .. .||.
srLdaAlgKtpllildgng..........................neptaadlellk...................eelydpelferlgikylripvpDg

GVPaTTKELLGFRLAVKDQlkRLNCTPLIHCSAGVGRTGTFIGldryIDRVLSKRDADVLDIVRDMRRARN-----FMIQFVYLFLVCLDAMDQLEKLLD
..| ... .. |  ....   . .   |.||.||.||||||.     .. ...... .. ....|.|..|       .|..  ... .|.|. .. | | 
sap.lledfdeflefieea..dkggpvlvHCkaGkgRtgtfvv....aaylmkllgvsleealedvrlkRpinpnpgfieqleqyefilealleylkflk

K
|
k
0043147 (Phosphotyrosine protein) phosphatases II 133-334 4.3e-32 106.6 In-house 4-147 (172) alignment 
Range on Protein: 133-334
Range on HMM: 4-147/172.0
NCDYVNANWIPSE-GPRKYIAAQGPVPASLVSFWQMVVEHDARLIVMLTNEieggklkchrywpddnmakashpqpvkkvkigtyivsfegeesfptyvh
..||.||....    |...|| ||| .  | .||.|. |.. ..||.||..                                                 
gsdyinasyldlyyipdrfiatqgplrntladfwrmlkelgithivnltel.................................................

rkfkLYLESGEARDVSQMAYTAWPDHGVPaTTKELLGFRLAVKD-QLKRLNCTPLIHCSAGVGRTGTFIGLDRYIdrvlskRDADVLDIVRDMRRARNFM
    ||. ... | . |  |. ||||||| ... || |   ... .... ... |.|||||||||||.. ..  .      .. .....|. .|..|. .
....lydpellerlgiqylylpwpDhgvp.llellleflefidellalspggpvlVHCsaGvgRtgtlvaaylml......lglsleeavalvrekRpga

IQFV
.|  
vqnp
subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 96-341 8.5e-32 105.2 In-house 25-267 (285) alignment 
Range on Protein: 96-341
Range on HMM: 25-267/285.0
SAATASRSDANQHLNRYSNIVAYDATRVLVpknkENFNCDYVNANWI--PSEGPRKYIAAQGPVPASLVSFWQMVVEHDARLIVMLTNEIEGGKLKCHRY
  .| .  .||  ||||... . . |||..    .|.. ||. |.|.  | .    ||..|||.| .|  ||.|. .     ..||   .|||  ||  |
pnctytayeanpdlnryadvrcieetrvvl....knhdrdyihaswmrmpgkdqstyittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekcaly

WPDDnMAkashpqpvKKVKIGTYIVSFE--GEESFPTYVHRKFKLYL-E--SGEARDVSQMAYTAWPDHGVPATTKELLGFRLAVKDQLKRlNCTPLIHC
.|.  .         . ||.| | ...    ||.    .   . .   |  | |   . ..    |||.  |  .. .. .   ||    . .    .||
ypek.lg........evvkfgkyeitlteckeeaiagtilnaltvintedasseplymnhvqvpwwpdqlapedarpmielykwvkkvnpk.ekpicvhc

SAGVGRTGTFIGLDRYIDRVLSKRDADVLDIVRDMRRARNFM----IQFVYLFLVCL
||||||| ||.|.|    |.. . . ..|||||.||  |       .||..|..| .
sagvgrtatfvgidyatirimenpniemldivremramrfqavqshmqflflyvvlm
0049260 (Phosphotyrosine protein) phosphatases II 147-333 1.4e-31 104.6 In-house 8-135 (152) alignment 
Range on Protein: 147-333
Range on HMM: 8-135/152.0
PRKYIAAQGPVPASLVSFWQMVVEHDARLIVMLTNEIEGGKLKCHRYWpddnmakashpqpvkkvkigtyivsfegeesfptyvhrkfklylesgeardv
|...||.||| | .| .||.|. |.... |||||.. | |||||..|.                                                    
pfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi....................................................

sQMAYTAWPDHGVPATTKELLGFRLAVKDQLKRLNCTPLIHCSAGVGRTGTFIGLDRYIdrvlskRDADVLDIVRDMRRARNFMIQF
 |  .. |||||||  .  || . |...  ... ... |.|||||||||||.. ..  .      .. .....|. .|..|. ... 
.qylhlpwpDhgvpdlsqlllflllfieklaldkggpvlVHCsaGvgRtgtlvaaylml......lgvsleeavalvrekRpgavpn
0044763 (Phosphotyrosine protein) phosphatases II 118-339 3.8e-30 100.2 In-house 2-162 (178) alignment 
Range on Protein: 118-339
Range on HMM: 2-162/178.0
YDATRVLVPKNKENFNCDYVNANWIPsegPRKYIAAQGPvpaslVSFWQMVVEHDARLIVMLTNEIEGGKLKCHRYWPDDNMakashpqpvkkvkigtyi
.| ||||...    . .|| ||..|    |. |.....|     ....... |.. ..||.||.|.|.|.|||..|||...                   
ldrtrvllsnleglersdyinaseil...pglylgslpp.....addlellkelgithivnlteelelgflkcdpywpeeag..................

vsfegeesfptyvhrkfklylesgeardvSQMAYTAWPDHGVPATTKELLGFRLAVKDQLKRLNCTPLIHCSAGVGRTGTFIGLDRYIDRvlskrDADVL
                              |. .. .||||||  .. .| |  .... |.. ... |.||||||||.||.. ..  . .     . .. 
.............................iqylhipipDhgvpdllehflefvefieealdekggpvlVHCsaGvgRsgtlvaaylmkkl.....glsle

DIVRDMRRARNfMIQFVYLFLV
.... .|..|. ...       
eaielvrerRp.ivpnpgqlrq
0051082 (Phosphotyrosine protein) phosphatases II 135-343 1.6e-29 97.8 In-house 4-148 (151) alignment 
Range on Protein: 135-343
Range on HMM: 4-148/151.0
DYVNANWIPSEgprkYIAAQGPVPaslvSFWQMVVEHDARLIVMLTNEIEGGklKCHRYWPDDNmakashpqpvkkvkigtyivsfegeesfptyvhrkf
|| |.... .     ... .|| .     |.... |.. . ||.|..| | |  .|..|.|. .                                    
dyinfsyvtgg....lyrsggpla....dflellkelgiktivnlrseeerg..ycpeylpelg....................................

klylesgeaRDVSQMAYTAWPDHGVPATTKELLGFRLAVKDqlkrL-NCTPLIHCSAGVGRTGTFIGLDRYIDRvlskrdADVLDIVRDMRRARNFMIQF
         ..| .. .. |||.|.| .....| |  .. |      |   |.|||||.|||||...|.. . .       .. ......|. |  ..| 
.........ievlhipildwpdpglplsfdavleflellld....kkngpvlvHCsaGkgRTGtlvalylmllg......vsleealeeyrlkrpgvvqp

VYLFLVCLDA
   ||..| |
nqqflfqlfa
subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 106-349 6.1e-29 95.7 In-house 50-283 (301) alignment 
Range on Protein: 106-349
Range on HMM: 50-283/301.0
NQHLNRYSNIVAYDATRVLVPKNKENFNcdyVNANWIPSEG-PRKYIAAQGPVPASLVSFWQMVVEHDARLIVMLTNEIEGGKLKCHRYWPDDNMakash
... .|| ..     | | | .. .      . |||||..| |...||.|||....   || |.| .|   ||||....|  . ||. | | .       
pkdkhryptvPckPstavevivdGkrvP...ihanwiptsGhphrfiatqgPlkntsedfwamlvqydvekivmlgqkvekleekceeylpvkis.....

pqpvKKVKIGTYIVSFEGEESFP--TYVHRKFKLYLESGE--ARDVSQMAYTAWPDHGVPATTKELLGFRLAVKDQLKRLnctpLIHCSAGVGRTGTFIG
    .|..|| . .  . .|.      ..|....   .|.  .| |    |. |.|.||| .  ||  .   ||.  | .    ..|||||.||. .|||
....ekldigrfkikiknkelilnkkiskrtlevedstgkfatrtvthyqysewtdrgvPkshaelfdlmelvkksekPi....vvhcsaGiGrsvafig

LDRYIDRVLSKRDADVLDIVRDMRRARNFMIQFV-YLFLVCLDAMDQLEK
 .    .|....  .. . ....|  |   .| .  |. . | .. .| |
teylareveadptieltealkhlrehrwngvqtnsqlywmtlGtvyrlik
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 103-338 6.1e-28 92.4 In-house 45-279 (305) alignment 
Range on Protein: 103-338
Range on HMM: 45-279/305.0
SDANQHLNRYSNIVAYDATRVLVpknKENFNCDYVNANWIPS-EGPRKYIAAQGPVPASLVSFWQMVVEHDARLIVMLTNEIEGGKLKCHRYWPDDNMAK
   ... ||| ..   |  || .   .  .  .|. ||.. .   |...| .| |.  .   || | ...    | || | .| |  ||. |.. ..  .
eaqeagknrykdvgcldnnrvkl...egpwpheyihanyvstptnpkrfictqaplektcadfwymclqdkveaifmlcnllekgakkcleyfaskdkdv

ASHPQPVKKVKI---GTYIVSFEGEESfPTYVHRKFKLYLESGEARDVSQMAYTAWPDHGVPATTKELLGFrlAVKDqlKRLNCTPLIHCSAGVGRTGTF
 .  .  .|. .    .  ..|. . .  .  . .. .    ..|| |..  .  ||| ||||.   .| .    |   . .     .|||||.||||. 
lefeekgqkisvkfessvtlkfrkdak.akvtetvlviegpgekarkvthyhwidwpdrgvpaadlailel..leka..rpskgpivvhcsagigrtgsv

IGLDRYIDRVLSKRDAD-VLDIVRDMRRARNFMIQFV--YLFL
. |.  .|..|. .  .    |.. .|  ||  ||    |||.
vmleyildqllagqiiedtdkilqkireqrnnsiqtdaqylfv
subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 98-324 2.2e-26 87.1 In-house 29-244 (281) alignment 
Range on Protein: 98-324
Range on HMM: 29-244/281.0
ATASRSDANQHLNRYSNIVAYDATRVLVPKNKENF-NCDYVNANWIPSEG-PRKYIAAQGPVPASLVSFWQMVVEHDARLIVMLTNEIEGGKLKCHRYWP
.|.     |.. |||.|| . | .|| .  .  |    ||. ||.| |    | || .|||   .   ||.|. . ..  |||| . .|  . ||  |.|
ctvfnqpvnnkknrylnipcldisrvqlkvkmpnknstdyihanyirspflkrgyiltqgpkketradfwrmiwqenttaivmlcqfletnrekcaeyfp

DDNMAKashpqpvkkVKIGTYIVSFEGEESFPTYVHRKFKLYLEsGEARDVSQMAYTAWPDHGVPATTKELLgfrlAVKDQLKRLNCTPLIHCSAGVGRT
 .  .          ...  . ||.|      . |  ...|  | ||.| ...  .  |||  || ... .|     .  ...     |.|||||||||.
rnahcc.........lqfdklsvsyedstvnkslvttrlnlsye.getrlithwlwkewpdwqvpessevml....kilrkirarstppvihcsagvgrs

GTFIGLDRYIDRVLSKRD-ADVLDIVRDMR
||.. ..  .. . |.    |. .||  .|
gtlmaveialqsihshftlpdikqivshlr
PTPc_DSPc_SM00012 246-344 3.7e-25 83.5 In-house 2-103 (105) alignment 
Range on Protein: 246-344
Range on HMM: 2-103/105.0
VSQMAYTAWPDHGVPATTKELLGFRLAVKDQLKRLN--CTPLIHCSAGVGRTGTFIGLDRYIDRVLSK-RDADVLDIVRDMRRARNFMIQFVYLFLVCLD
|... ||.||||||| .....| .  |||.. .  .     ..||||||||||||. ||  .... .. .  |...||. .|. |. |.|. . .|....
vkhyhytgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqylflyr

AM
|.
al
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 98-340 4.4e-25 83.2 In-house 25-251 (267) alignment 
Range on Protein: 98-340
Range on HMM: 25-251/267.0
ATASRSDANQHLNRYSNIVAYDATRVLVPKNKENfncdYVNANWIPS-EGPRKYIAAQGPVPASLVSFWQMVVEHDARLIVMLTNEIEGgklKCHRYWPD
 . | .  ||  ||. . . || ||| . ...|.    |.|| .. . .  ...|. |.|.  .   |.... ...   ||.||.  ..   . ...|| 
isqsiaeknqernrlddnlpyddtrvilrtkeee....yinasyvegyktknafivtqdplkntitdfltvihdqkvpvivlltkvftd...nirlfwPP

dNMAKAshpqpvKKVKIGTYIVSFEGEESFPTYVHRKFKlyLESGEARDVSQMAYTAWPDHGVP-ATTKELLGfrLAVKDQLKRLNCTPLIHCSAGVGRT
 .|..|      || .  |   |.| ||     .  ..|  ..   |..|.   |  |          | |.|  .  |.||.  |   ...||.||||.
.kmgqa......kkyqdltvehslekeendyqiitlelk..fknesahnvtlyyykkwnintnnkpylkplfg..ilaknqlengnrPlvvacsdGvGrs

GTFIGLDRYIDRVLSKRDADVLDIVRDMRRARNFMIQFVYLFLVC
|||. .|  ..|.     .|. | .| .|  |  ...    .. .
Gtflvidsqleraktegvsdifdflrkirsqriglvdtkeryiyi
subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 103-334 4.4e-25 82.9 In-house 49-276 (310) alignment 
Range on Protein: 103-334
Range on HMM: 49-276/310.0
SDANQHLNRYSNIVAYDATRVLVPKNKENFNcDYVNANWIPSEGPRK-YIAAQGPVPASLVSFWQMVVEHDARLIVMLTNEIEGGKLKCHRYWPDDNMAK
   . | ||||..|  |..|| .  .|  .. ||. ||.. ..  |. .| .|||.  ... ||.|. .  |  |..| .  | |. ||  |||   ...
ykkymhknrysdvvcldtsrvklkidksrye.dyihanyvktnylrstficsqgplqhtiidfwrmifqeraesilllckvgeegrpkcvgywpslgvte

ASHpqPVKKVKIGTYIVSFEGEESFPTYVHRKFKLYLESGEA--RDVSQMAYTAWPDHGVPATTKELLGFRLAVkdQLKRLNCtpLIHCSAGVGRTGTFI
.     ..  ...     ||  .   |.|  .  .  .  .     || . .  ||| |||      .  ||    |..   |  ..|||||..|... .
tyg..cirvtnlsesseefeicnlavtfvpdnvpvdeqpanlkelrvslikwpnwpdrgvpdekchtvpqrlla..qvrhgpc..vvhcsagkdrlyvvv

GLDRYIDRVLSKRDADVLDIVRDMRRARNFMIQFV
 |.  ||..      |. ... .... |   ||  
alklkidkldrglkvdaeevktellksraiciqte
subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 107-361 5.8e-25 82.6 In-house 44-287 (312) alignment 
Range on Protein: 107-361
Range on HMM: 44-287/312.0
QHLNRYSNIVAYDATRVLVPkNKENFncdYVNANWIP-SEGPRKYIAAQGPVPASLVSFWQMVVEHDARLIVMLTNEIEGGKLKCHRYWPDDNMAKASHP
. |||| ||  .|  |  .    |||   |. ||..     | .....|||.  . . |||...   .  |..|.  .| |  || .|  |         
kdlnrypniqcwdrgrftla.gdenf...yihanfvkictkperfvctqgplentcthfwqlalslgstsiillcgfvedgsekcakyisdivgfvdled

QPVKkVKIGTYIVsfEGEESFPTYVHRKFKLYLE-SGEARDVSQMAYTAWPDHGVPATTKELLGFRLAVKDQLKRLnctpLIHCSAGVGRTGTFIGLDRY
. |   .  | |    |  |     || .|. .  .|.   . .  ...|||||.| .    | .  ||| . | .    . |||||||||||.. ..  
hrvy.teycteie..iggkskdkithrvlkvvvkatgqesklnhyqwaswpdhgmpdscdtalrllsavkkdkkpv....iahcsagvgrtgtlaliesm

IDRVLSKRDADVLDIVRDMRRARNFMIQFVYLFLVCLDAMdqLEKLLDKYLALATKS
|  .   |  .| |.   .|. |   .. .  .. .| ..  || |  | |    . 
iaalrhprkqnvkdsfvllrkdrarsvrvfpqyvyalrcv..leflyskglykrneq
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 106-337 2.2e-22 74.5 In-house 43-264 (288) alignment 
Range on Protein: 106-337
Range on HMM: 43-264/288.0
NQHLNRYSNIVAYDATRVLVPknkenFNCD-YVNANWIPSEGP-RKYIAAQGPVPASLVSFWQMVVEHDARLIVMLTNEIEGGKLKCHRYWPDDNMAKAS
|   .|| |.   |.||| .       ..| |..|| ..|.   |. | || |. . .  .|.|..| | . ||||.. .| || |   |.|     || 
nptrdryenlprcditrvkls.....ddpdfyiaanvvssakykrrlicaqaPlngtieelWkmllesdveyivmlcellekGkeksaeyfPsklGekar

HPQPVKKVKIGTyivsfegeESFPTYVHRKFKLYLESGEARD-VSQMAYTAWPDHGVPATTKELLgfRlaVKDQLKRLNCTPLIHCSAGVGRTGTFIGLD
  .  . ||           .     |.       . || .  | .. .  |.|.|||   .  |  |  . . || |.   ..|.|||||||||.|   
igrlctvvkkkr........adidklvkvsllriskegeekvivkilhlleWdddgvPenylspl..r..llevlkslqkPivvhssaGvGrtgtlilil

RYIDRVLSKRDADVLDIVRDMRRARNFMIQ----FVYLF
  .. . .. .  .  ..  .|  |   ||    ..|..
ialeslrlddflgirsllaklreerfkaiqtemqylyvh
subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 158-339 6.5e-22 72.3 In-house 101-283 (302) alignment 
Range on Protein: 158-339
Range on HMM: 101-283/302.0
PASLVSFWQMVVEHDARLIVMLTNEIEGGKLKCHRYWPDDNMAKASHP-QPVKKVKIGTYIVSFEGEESFPTYVHRKFKLYLESGEARDVSQMAYTAWPD
  .|  .| .. ...  ..| |.. .|... ||  |. |.   .       || |.. | .  |   .||  |         ..   . |. .|..||||
kstlekhwalieqynvaivvqlcsfvedeekkcaeyysdkvggelkfgrytvktvsvktdleeftdkksfklytveiknekkkkkvkktvdilafsawpd

HGVPATTKELLGFrLAVKDQLKRlncTPLIHCSAGVGRTGTFIGLDRYIDRVLSKRDADVLDIVRDMRRARNFMIQ----FVYLFLV
|| |. ..  |   |   .  |.   . |.|||||||||||.. .   |.  . |. .|.|.||  .|. |   .|     .||.|.
hGapkeaytaldi.lkfcesykk...nvlvhcsaGvGrtGtlvaikyGiqlcskkkvtdllsivlpvrqcryGavqdeqqliylllc
subfamily_CG42327_pd Subfamily CG42327 107-279 1.1e-21 71.8 In-house 29-196 (319) alignment 
Range on Protein: 107-279
Range on HMM: 29-196/319.0
QHLNRYSNIVAYDATRVLVPKNKENFNCDYVNANWI--PSEGPRKYIAAQGPVPASLVSFWQMVVEHDARLIVMLTNEIEGGKLKCHRYWPDDNMAKAsh
.  .|. |.|    ||| ...  .. .  |..|...  . . |  ||||| .   |  .||..| |  .| || ||.  | |  .| .|.|  .  .   
kdksrvinvvPlPetrvvlqrigdddkdeyldasyvrGyddapnsyiaaqvsledsssdfwrtvweqqsrvivqltdlselGikvcaeylPtketldn..

pqpvkKVKIGTYIVSFEGEESFPTYVHRKFKL-YLESGEARDVSQMAYtAWPDHGVPATTKELLGFRLAVKDQLKR
     .   | . |.. | |.   |.   . |  ..  |.|...   |  |.. .|||  . |.   | |.. || 
.....tslyGdilvtlkgrevkdryaistlllkrvdkeesrelthywy.kwleaevPaeeaaliamllevrsslks
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 109-200 1.3e-19 65.1 In-house 50-156 (350) alignment 
Range on Protein: 109-200
Range on HMM: 50-156/350.0
LNRYSNIVAYDATRVLVP--------KNKENFNCDYVNANWIPSE-------GPRKYIAAQGPVPASLVSFWQMVVEHDARLIVMLTNEIEGGKLKCHRY
 |||.||. |. .|| ..        |..     ||.|||..  .          ||||.|.|.|  .  |...... . ..|..||...| .  ||.||
knrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvkvilsltsdvelnlekcyrY

WPDDNMA
|.. .. 
Wqegsyd
0048076 (Phosphotyrosine protein) phosphatases II 219-338 1.7e-18 62.2 In-house 15-133 (145) alignment 
Range on Protein: 219-338
Range on HMM: 15-133/145.0
SFEGEESFPTYVHRKFKL-----YLESGEARDVSQMAYTAWPDHGVPATTKELLGFRLAVKDQLKRlNCTPLIHCSAGVGRTGTFIGLDRYIDrvlskRD
|.   ...... . ....     . .... | . |  |. |||||||  .. || |  .... ||. ..  |.|||||||||||.....  .      ..
slptaldlellkdlgittvlnltselellerlgiqylylpwpDhgvpdllellleflefieealke.ggpvlVHCsaGvgRtgtlvaaylmll.....lg

ADVLDIVRDMRRARNFMIQFVYLFL
 .. .... .|..| .... .  . 
vsleealelvrsqrpgavpnpgqlr
0048179 (Phosphotyrosine protein) phosphatases II 232-335 2.1e-17 58.7 In-house 48-132 (144) alignment 
Range on Protein: 232-335
Range on HMM: 48-132/144.0
RkfklylesgeardVSQMAYTAWPDHGVPATTKELLGFRLAVKDQLKrLNCTPLIHCSAGVGRTGTFIGLDRYIdrvlsKRDADVLDIVRDMRRARNFMI
              . |  .. |||||||  .. || |  .... |.  ..  |.|||||||||||.. ... .     |.. .. .... .|..| ...
e.............giqylhlpwpDhgvpdllellleflefieeale.eggpvlVHCsaGvgRtgtlvaaylmk.....klglsleealalvrsrrpgav

QFVY
.   
pnpg
subfamily_egg_pd Subfamily egg 99-338 1.2e-14 48.7 In-house 33-260 (307) alignment 
Range on Protein: 99-338
Range on HMM: 33-260/307.0
TASRSDANQHLNRYSNIVAYDATRVLVPKNKENFNCDYVNANWIPSeGP--RKYIAAQGPVPASLVSFWQMVVEHDARLIVMLTNEIEGgkLKCHRYWPD
| . || |..  |   .   | .|| .  ..  .  |.. || .   .|   ..| || |.  .   ||.|| . . . |||||   |    .|. ||| 
ttaasdnnlekarskrvhckdssrvklelrrGqylddfihanrvkG.kpllnefilaqaplkntvddfwrmvfqeevqyivmltsrkes..erceyywpk

dnmakaSHPQPVKKVKIGTYIVSFEGEeSFPTYVHRKFKLYLeSGEARDVSQMAYTAWpdhGVPATTKelLGFRLAVKDQLKRLNCTPLIHCSAGVGRTG
      .. .... |  .  | ... . | .  . |  || |  |  ..   . .  .    |  ...  . . | |  .|..|    ....  || ...
......aesdslvtvpGslrienlkvd.skadplfrvtklkl.vGgddeerflehwqg...dvnnssd..vysplrvlrklrnlskpvvvqdilGvskaa

TFIGLDRYIDRVLSK--RDADVLDIVRDMRRARNFMIQFVYLFL
|.. ..  .  .|        ||  |  .|. |.. .. | |.|
tlvaieiallsllrGpitkslvlravvflrlrrrlsvesvllyl
subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 146-331 3e-14 47.7 In-house 3-187 (199) alignment 
Range on Protein: 146-331
Range on HMM: 3-187/199.0
GPRKYIAAQGPVPASLVSFWQMVVEHDARLIVMLTNEIEGGKLKCHRYWPDDNMAKASHpqpvKKVKIGTYIVSFEGEESFPTYVHRKFKlyLESGEARD
| |.|||.| |.  ..  ||||| |  .  |||. ..    .     |||  . . . .      . . |  .. . . .  . .  .         .|.
gqrryiatqhplretmadfwqmvwetgsghivmvnddqknkeadypfywpttesgtgky....gslsvttktittkpdytitaliltnnt..tappstre

VSQMAYTAWPDHGVPATTkELLGFRLAVKDQLKRLN---CTP-LIHCSAGVGRTGTFIGLDRYIDRV-LSKRD-ADVLDIVRDMRRARNFMI
.|.  .|.| ..  |  .  ..|| .| ..  |. .    .| ..||| | | || |. ||  .     ||    |.... . .|.||  .|
ishyqftswkekttpnva.lfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgii
subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 160-336 3.2e-14 47.6 In-house 40-173 (255) alignment 
Range on Protein: 160-336
Range on HMM: 40-173/255.0
SLVSFWQMVVEHDARLIVMLTNEIEGGKLKCHRYWPDDNMAKashpQPVKKVKIGTYIvsfegeeSFPTYVHRKFKLYLESG---EARDVSQMAYTAWPD
..  |.|..|  ..  .|||..  | |. ||..|.| .   |    . ...|.. |         |    | |  .. .. |   ....|    |. |..
tvdkfyqtivqtktevvvmlcdfaeegvekcssyfplekdek....lkladvnvtttk.......ssadvvlrtleitstlgekkkthtvkhysykGWie

HGVPATTKELLGFRLAVKDQlKRLnctpLIHCSAGVGRTGTFIgldryidrvlskrdadvldivrdmrrarnfMIQFVYL
.  |  ..|.|    .|.|  | .    ..|||.|.||. .|.                              ....|| 
knaPelareilnilkvvrds.ksv....vvhCstGiGrsaafv..............................laelvyq
subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 146-331 3.9e-14 47.3 In-house 2-186 (198) alignment 
Range on Protein: 146-331
Range on HMM: 2-186/198.0
GPRKYIAAQGPVPASLVSFWQMVVEHDARLIVMLTNEIEGGKLKCHRYWPDDNMAKASHpqpvKKVKIGTYIVSFEGEESFPTYVHRKFKlyLESGEARD
| |.|||.| |.  .|  ||||| |  .  |||. ..    .     |||  . . . .      . . |  .. . . .  . .  .         .|.
gqrryiatqhplretladfwqmvwetgsghivmvnddqknkeadypfywpttesgtgky....gslsvttktittkpdytitaliltnnt..tappstre

VSQMAYTAWPDHGVPATTkELLGFRLAVKDQLKRLN---CTP-LIHCSAGVGRTGTFIGLDRYIDRV-LSKRD-ADVLDIVRDMRRARNFMI
.|.  .|.| ..  |  .  ..|| .| ..  |. .    .| ..||| | | || |. ||  .     ||    |.... . .|.||  .|
ishyqftswkekttpnva.lfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgii
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 237-342 2.9e-13 44.0 In-house 82-188 (440) alignment 
Range on Protein: 237-342
Range on HMM: 82-188/440.0
YLESGEARDVSQMAYTAWPDHGVPATTKELLGFRLAVKD-QLKRLNCTPLIHCSAGVGRTGTFIGLDRYIDRVLSKRDADVLDIVRDMRRARNFMIQFVY
|... |.| . |. | .|||.|||  .  .| .   |.. | |  |   |.|||||.||||  | .|  .  .    . |.. ..  ||  |  |.|   
yingiesrtlkqyhyqgwpdkgvpkfagpvlkmiqdvnesqekagngpllvhcsagagrtgviiavdsilreakrsdqidifsfinsmrnnrpqmvqtpe

LFLVCLD
 . .  .
qyafvhe
subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 116-338 5.6e-12 40.4 In-house 28-251 (290) alignment 
Range on Protein: 116-338
Range on HMM: 28-251/290.0
VAYDATRVLVPKNKENFNCDYVNANWIPSEGPRKYIAAQGPVPAS-------LVSFWQMVVEHDARLIVMLTNEIEGGKL----KCHRYWPDDNMakash
    ||||     .. || ||. || .      . |. | |  .        . .|| |. .  .. .||| .  |  .      | .| |.        
pLveatrvvLkgygkrfnddyiHAnrvtcpnglrliltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCakYvpesvg.....

pqpvKKVKIGTYIVSFEGEESFPTYVHRKFKLYLESGEARDVSQMAYTAWPDHGVPATTKELLgfrlAVKDQLKRLNCTPLIHCSAGVGRTGTFIGLDRY
    ...|..   |.    |      .|.  .  . .|   |    .  | .  |. .|| ||    .. ...|  . . ..||  |. |  ..  ..  
....eelkfkgltvkCkskekeddvetRelvvkfddeeeftvtHsllkgWnklnvqedtktll....sliqkvkasktpvivHcvdGiSrsAalaaiilg

IDRVL----SKRDADVLDIVRDMRrARNFMIQFVYLFL
   .     |   .|||. .| .| |  .. .  . | 
yQkiaetsgsvkledvlkalrkqr.alaitsalelafv
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 110-200 8.6e-12 39.0 In-house 52-159 (349) alignment 
Range on Protein: 110-200
Range on HMM: 52-159/349.0
NRYSNIVAYDATRVLVPKNKEN--------------FNCDYVNANWIPS---EGPRKYIAAQGPVPASLVSFWQMVVEHDARLIVMLTNEIEGGKLKCHR
|||..|. |. .|| ..|  ..                 ||.|||..     .  .|||| | |.|...  |.....    .|.. |... | .  ||..
nrykdilPyehsrvklkkslksskvikastsesdsgklddyinanylkltrisvekkyiatqaPlPstvddfykvillngvklvlsLnddkelslekcdi

YWPDDNMA
|| . . .
ywqelsys
subfamily_Sponge-PTP3_pd Subfamily Sponge-PTP3 74-155 4.8e-11 36.7 In-house 16-95 (95) alignment 
Range on Protein: 74-155
Range on HMM: 16-95/95.0
AHSANNNAGFIETFTSIRDGLGSAATASRSDANQHLNRYSNIVAYDATRVLVPKNKenfNCDYVNANWIPSEGPR-KYIAAQG
   .| .  | . | ||    |.. |.  |.||   ||. ||. |||||| .  ..   . ||.|| ..     .  ||||||
emhsnsdqefdnefksismtsgapytvgsseanipknrflnifpydatrvvlttkr...dsdyinacfvdgyarkncyiaaqg
subfamily_eak_pd Subfamily eak 106-308 5e-11 36.6 In-house 52-263 (332) alignment 
Range on Protein: 106-308
Range on HMM: 52-263/332.0
NQHLNrYSNIVAYDATRVLVPKNKENFNcDYVNANWIP-SEGPRKYIAAQGPVPASLVSFWQMVVEHDARLIVMLTNEIEGGKLKCHRYWPDDN--MAKA
. . |   .|| ||   | .   . | .  |.||  .  ||  |||| .  .    .  |||||.|  .  ||.| ...| .  |  .|.||.     | 
avnrn.vvkivpydrylvrltssqlnrl.GyinaslaefsevGrkyiltGiasedkvfafwqmvleqkspaivqlledvelkleksdkyfpdktreelkf

SHPQP-----VKKVKIGTYIVSF-EGEESFpTYVHRKFKLYLESGEARDVSQMAY-TAWPDHGVPATTKEL-LGFRLAVKDQLK-RLNCTPLIHCSAGVG
 . .      ||. .. |  .    |.|.     | |.  . |    .    .|.  .  . ||.         ..  .|   .     .|.| .. |  
GildverkefvkrniletrllelskGneth.rvlhykvfGwtettlpkyedflalrkvmkevGvlllivmksallsstlkkyihtppsfapiiqsarGsa

RTGTFIGLDRYIDRV
|.|.|. .|  |  .
raGvfvvidllirli
subfamily_hpo-7_pd Subfamily hpo-7 162-306 7.1e-11 36.5 In-house 48-179 (263) alignment 
Range on Protein: 162-306
Range on HMM: 48-179/263.0
VSFWQMVVEHDARLIVMLTNEIEGGKLKCHRYWPDDNMAKashpQPVKKVKIGTYIVSFegeesfpTYVH--RKFKLYLE-SGEARDVSQMAYTAWPDHG
 .|.|..|   .  .|||..  | |. || .|.| .   |    | ...|.. |  |           .   ...  .|.   . ..| .  |. |... 
dkfyqtivqtktevvvmLcDfneegvekcssyfPlekdek....qklanvnvcttkvqs.......dvllktlellstlgeKkkthtvkhysykgWiekn

VPATTKELLGFRLAVKDQlKRLnctpLIHCSAGVGRTGTFIGLDRYID
 |  ..| |    ....  |.|     .|||.|.||.  |   .    
dpelareilnilkvarns.ksl....vvhcstGiGrsaafsvaElvyq
subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 86-334 1.2e-10 35.5 In-house 27-265 (303) alignment 
Range on Protein: 86-334
Range on HMM: 27-265/303.0
TFTSIRDGLGSAATASRSDANQHLNRYSNIVAYDATRVLVPknkenfNCDYVNANWIPSEGPRKYIAAQGPVPASLVSFWQMVVEHDARLIVMLTNEIEG
 |  .   |    .  .   | . ||. ...  | ..| .       .  |. |...  .  .| | .| |.. .   ||||..|   . ...|  . | 
efekvvsylppsvsknqfvknmdknrfvdvicldhskvkls......dssyihasyleldsskkailtqlplshtaadfwqmiieqkvkcvlllltdsey

GKLKCHRYWPDDNMAKASHPqpvKKVKIGTyivsFEGEESFPTYVHRKfkLYLESGEARDVSQ-MAYTAWPDHGVPAT-TKELLGFRLAVKDQLKRL-NC
 ||  .  .| ..          . ...|     |   |    .| .   | .  |. .   .   | |||   .|.  . ...     ..  |..  ..
dklggdsvfprnqdflkfee...rsirvge....fkrvelgdgwvlkv..lsvsngdyksflhvhhykawphnsipsdgspkfvkqiwqlqsvlrkysds

TPLIHCS-AGVGRTGTFIGLDRYiDRVLsKRDADVLDIVRDMRRARNFMIQ---FV
|| .. | .|.||.|||  ..      | . .   ||.|. .   ||  ..    .
tptvymslsgcgragtfalfeta.hlsl.hseqasldlvkclenvrngrlhavqnl
subfamily_Sponge-PTP-7_pd Subfamily Sponge-PTP-7 286-344 7.9e-10 33.0 In-house 3-61 (69) alignment 
Range on Protein: 286-344
Range on HMM: 3-61/69.0
IHCSAGVGRTGTFIGLDRYIDRVLSKRDADVLDIVRDMRRARNFMIQFVYLFLVCLDAM
.|||.| ||||||| .   . |. |..  |... |. ||. |  |.     ..   ||.
vhcssgtgrtgtfiaimvemarikseklvdifnnvqymrkcrpmmvmneieyifihdal
subfamily_Sponge-PTP7_pd Subfamily Sponge-PTP7 286-344 1.1e-09 32.5 In-house 2-60 (69) alignment 
Range on Protein: 286-344
Range on HMM: 2-60/69.0
IHCSAGVGRTGTFIGLDRYIDRVLSKRDADVLDIVRDMRRARNFMIQFVYLFLVCLDAM
.|||.| ||||||| .   . |. |..  |... |. ||. |  |.     ..   ||.
vhcssGtGrtGtfiaimvemarikseklvdifnnvqymrkcrpmmvmneneymfihdal
0038934 (Phosphotyrosine protein) phosphatases II 252-326 1.9e-08 29.7 In-house 85-158 (194) alignment 
Range on Protein: 252-326
Range on HMM: 85-158/194.0
TAWPDHGVPATTKELLGFRLAVKDQLKRL-NCTPLIHCSAGVGRTGTFIGldRYIDRVLSKRDADVLDIVRDMRRA
  .||.|.. ... || |  .|.. |..  ... ..|| ||.|||||...  .|.  .|     . ....|..|. 
lpfpddgtvPsleillrfldlvdeflnedpggvvaVHCkaGlgRtGtlva..aYLiyrlgmsaeeAialfrekRpg
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 282-348 9e-08 26.2 In-house 262-344 (350) alignment 
Range on Protein: 282-348
Range on HMM: 262-344/350.0
C-TPLIHCSAGVGRTGTFIGLDRYID--RVL---------SKRDADV----LDIVRDMRRARNFMIQFVYLFLVCLDAMDQLE
  . |.|||||||||||.. ||  .    .|         ... | .      ||  .|. |  |.| .  |... .|.  . 
sspilvhCsaGvGrtGtlvtlDsllsdfeilenltkesrkldvaaktrDlisiivnelrkqrismvqnldqfifiYeallfyf
subfamily_CG42327_pd Subfamily CG42327 286-332 7e-07 23.2 In-house 252-299 (319) alignment 
Range on Protein: 286-332
Range on HMM: 252-299/319.0
IHCSAGVGRTGTFIGLDRYIDRVL-SKRDADVLDIVRDMRRARNFMIQ
.||| ||||||. |  |  | ..  |||  |. ..|  .|| |   ..
vhcsdGvGrtGlviasdiairsleeskrsvdiPqlvssvrrdrasavl
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 282-313 1.6e-06 21.7 In-house 266-296 (349) alignment 
Range on Protein: 282-313
Range on HMM: 266-296/349.0
CTPLIHCSAGVGRTGTFIGLDRYIDrVLSKRD
 | |.||||| ||||... ||  .. .|.   
stllvhcsaGcGrtGvlvtldllls.ileplq
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 82-143 3e-06 20.8 In-house 23-84 (440) alignment 
Range on Protein: 82-143
Range on HMM: 23-84/440.0
GFIETFTSIRDGLGSAATASRSDANQHLNRYSNIVAYDATRVLVPKNKENFNCDYVNANWIP
 | . .. .  || . .  .    |.  ||| ||.||| .||.. . |   . ||.|| .| 
afedewsllpsglsqpsdiaslpnnkvknryrnilaydhsrvmleevkgvpdsdyinasyin
subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 99-190 3e-06 21.0 In-house 30-127 (347) alignment 
Range on Protein: 99-190
Range on HMM: 30-127/347.0
TASRSDANQHLNRYSNIVAYDATRV-LVPKNKENFNCD----YVNANWIPSE-GPRKYIAAQGPVPASLVSFWQMVVEHDARLIVMLTNEIEGGKLKC
|..  . .   ||  .    ||||| | |.. .| ..|    |.||  |  .   ..|| .| |.| ..  ||.||       .| . . |.   .. 
tsvewekslsknrskdvklidatrvvlspeksknsraddvetyinashikfdnaskeyiltqyplpdtvrdfwkmvsvtkvtqvvtifepikdeaiee
PTEN_1 252-299 9e-06 20.6 In-house 100-148 (196) alignment 
Range on Protein: 252-299
Range on HMM: 100-148/196.0
TAWPDHGVPATTKeLLGFRLAVKDQLKRLNC--TPLIHCSAGVGRTGTFI
  ..|||.|   . |. .   ....|.....  . |.|| ||.||.|| .
fpieDhgapslse.lfdicksfiewllsdpngnvVlVHCkaGlgRsGtvv