Gene MbrePTP-sf1-5 in Monosiga brevicollis

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily MbrePTP-sf1
Protein sequence
ID Type Fasta BLAST phosphatome Note
MbreP036_AA protein Get Run
MbreP036_AA_65-351 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 67-348 2.9e-121 398.9 In-house 1-280 (281) alignment
Range on Protein: 67-348
Range on HMM: 1-280/281.0
KLRAQIKAHSANNNAGFIETFTSIRD-GLGSAATASRSDANQHLNRYSNIVAYDATRVLVPKNKENFNCDYVNANWIPS-EGPRKYIAAQGPVPASLVSF
.||...|..|.|.||||||....... |....||||..|.|.. |||||||||||||| | .|.|| |.||.|||..|. .|...|||.|||||||||.|
alrkhlkqlsqndnaGfieeyeklaaigvdntataskadenvlknrYsnivaYDatrvkvtpneenkntDYinanfvpgykgekeyiatqgPvPaslvaf

WQMVVEHDARLIVMLTNEIEGGKLKCHRYWPDDNMakashpqpvkKVKIGTYIVSFEGEESFPTYVHRKFKLYLESGEARDVSQMAYTAWPDHGVPATTK
||||.|.....|||.|.|||.|||||||||||||           ..|.|...|... ||. .||..|||||. ||||.|.|.|.|||||||||||||||
WqmvweqkvsaivmvtreieagklkChrYWPddns..........elkygdvtvkstaeeekatyierkfkleresgetreveqlaytaWPdhGvPattk

ELLGFRLAV-KDQLKRLNCTPLIHCSAGVGRTGTFIGLDRYIDRVLSK-RDADVLDIVRDMRRARNFMIQ----FVYLFLVCLDAMDQLE
|||.|| .| | . |. ... .||||||||||||.|.|||....| .. ...|| ..|...|..||.|.|    . ......|||.|. .
ellefrkevlkltekktkaplvihCsaGvGrtGtyialDrlvkaveaeleeldvkavvaelrkernlmvqtvvqyefvykavldaldkel

subfamily_PTPRD_pd Subfamily PTPRD 65-349 1.7e-79 263.0 In-house 7-286 (564) alignment
Range on Protein: 65-349
Range on HMM: 7-286/564.0
SQKLRAQIKAHSANNNAGFIETFTSIRDGLGSAATASRSDANQHLNRYSNIVAYDATRVLVPKNKENFNCDYVNANWIPS-EGPRKYIAAQGPVPASLVS
 ..|.. ..   ||... | | . .|. |  .  .|.. .||.. |||.||||||..||   | . . ..||.||..| . . ...|||.|||.. ..  
vaelkehvaklkansdlkfeeeykkieegqqftweaankpaNkaKNRyanivaYdhsRVvLskvegdegsDYINAsfidgyrkrkayIAtqgPlaetied

FWQMVVEHDARLIVMLTNEIEGGKLKCHRYWPDDNmaKAshpqpvkkvKIGTYIVSFEGEESFPTYVHRKFKLYL-ESGEARDVSQMAYTAWPDHGVPAT
||.|| |.. . |||||.  | || |||.|||...  ..         ..| ..|..| || . .|. |.|||   .| |.| | |  .|.||||||| .
FWRmvweqnsstiVmltkleEkgkvkchkYWPekg..te.........tygeltVtleeeeeladyeirtfklkkkkssesreVrqFhFtsWPdhgvpes

TKELLGFRLAVKDQLKRLNCTPLIHCSAGVGRTGTFIGLDRYIDRVLSKRDADVLDIVRDMRRARNFMIQ----FVYLFLVCLDAMDQLEK
...|| ..  |..  .. .   ..||||||||||||| .|  ..|. .... |.  .|. .|. ||.|.|    ..... . |.|..  ..
atslLdlirkvralnepdagPivVhCSaGVGRTGtfividamlerikeektvDiyqyvkalrkqRnamVqteeQYiFiheailealacgnt

subfamily_PTPRB_pd Subfamily PTPRB 66-338 5.6e-75 247.1 In-house 10-275 (293) alignment
Range on Protein: 66-338
Range on HMM: 10-275/293.0
QKLRAQIKAHSANNNAGFIETFTSIRD-GLGSAATASRSDANQHLNRYSNIVAYDATRVLVPKNKENFNCDYVNANWIPS-EGPRKYIAAQGPVPASLVS
.|. . .|  .|.....| | . .... |   | .|... .|.  |||.||..||..|| . . |.. . ||.|||.||  . ||..||.|||.| ..  
ekfeehvkkmkadsdlrfseeyeelkavgkdqavkaaelavnraknrytnilpydhsrvkLaalkdesgsDYinanyipgynsprefiatqGPlpetvdd

FWQMVVEHDARLIVMLTNEIEGGKLKCHRYWPDDnmakashpqpVKKVKIGTYIVSFEGEESFPTYVHRKFKLYLeSGEARDVSQMAYTAWPDHGVPATT
||.|| |. .. |||||. .|.|| ||..|||.|           . |  |   |..  ||.   .| |..|.   . | |.| |. .|.||||||| .|
fWrmvwekkssiivmltqlvekgkvkCeeYWPad..........eepvlyGdikvtlvaeeeledwvirelkiek.ekeerkvrqyhftsWpdhgvPekt

KELLGFRLAVKDQL-KRLNCTPL-IHCSAGVGRTGTFIGLDRYIDRVLSKRDADVLDIVRDMRRARNFMIQFVYLFL
| || |  .|.... |  . .|. .||||||||||||| ||| .... ..   |.. || ..|. ||...| .  ..
ktlldfvrtvreaiektaskrPivvhCsaGvGRtGtfialdrllqaieeedyvdifgivaelReeRnllvqtekqYi

0051299 (Phosphotyrosine protein) phosphatases II 66-344 4.4e-74 244.8 In-house 8-282 (288) alignment
Range on Protein: 66-344
Range on HMM: 8-282/288.0
QKLRAQIKAHSANNNAGFIETFTSIRDGLGSAA-TASRSDANQHLNRYSNIVAYDATRVLVPKNKENFNCDYVNANWIPS-EGPRKYIAAQGPVPASLVS
..|.  .... ||...|..| |  ... | .   .|..  .|.. ||||.|..|| .|| .   ... ..||.||..|.  . .||.||.||| | .. .
eellklvlkllangltglleefeellsllpdltlsaallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyidgynlkrkfIatqgPlpntved

FWQMVVEHDARLIVMLTNEIEGGKLKCHRYWPDDNMAKAshpqpvkkvkiGTYIVSFEGEESFPTYVHRKFKLYL-----ESGEARDVSQMAYTAWPDHG
||.|| |.. |.|||||...| |. ||..|||.... .            | . | .  ||....|..|....        .|| | | .. ||.|||||
FWrmvweqnvrvIvmltklvelgrekcaqYwplggslty...........gditvtllseevlddytvrtlevtnldlldgdgesrtvthfhytnwpdhg

VPATTKELLGFRLAVKDQLKRLNCTPLIHCSAGVGRTGTFIGLDRYIDRVLSKRDADVLDIVRDMRRARNFMIQFVYLFLVCLDAM
|| ....|| |  .|...|.  ... ..||||||||||||| ||  ..... ..  |||..|. .|. |..|.| .  .. . .|.
vpdspellldflrlvrkalasgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtpeqyrfvyeal

0050432 (Phosphotyrosine protein) phosphatases II 76-345 4.9e-73 241.5 In-house 37-296 (308) alignment
Range on Protein: 76-345
Range on HMM: 37-296/308.0
SANNNAGFIETFTSIRDGLGSAA-TASRSDANQHLNRYSNIVAYDATRVLVpknkeNFNCDYVNANWIPSE---GPRKYIAAQGPVPASLVSFWQMVVEH
.|... .. | |  ...   .   ....  .|...|||..|..|| .|| .     . ..||.||....      |||.||.||| | .. .||.|| |.
kaldlglleeefeellsvkplleysvallpenkdkNrykdilpydhsRVkl.....degsdYInAsyvdgyssklprkfIatqgPlpntvedFwrmvweq

DARLIVMLTNEIEGGKLKCHRYWPDD---NMAKAshpqpvkkvkiGTYIVSFEGEESFPTYVHRKFKLYL-ESGEARDVSQMAYTAWPDHGVPATTKELL
. |.|||||...| |. ||..|||..   .  .            | . | .  ||....|..|...|   ..|| | | .. ||.|||||||  ...||
nvrvIvmLtklvengrekcaqYwplelgggsley...........gkftvtllseevlddytvrtleltnlgdgesrtvthfhytnWpdhgvPpspeill

GFRLAVKDQLkrLNCTPLIHCSAGVGRTGTFIGLDRYIDRVLSKRDADVLDIVRDMRRARNFMIQFVYLFLVCLDAMD
 |  .|...|   ... ..||||||||||||| ||  ....  ..  ||...|. .|. |..|.| .  .| . .|. 
dflelvrksl..pggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtpeqylflyrall

0040438 (Phosphotyrosine protein) phosphatases II 72-352 1.7e-72 239.7 In-house 9-280 (317) alignment
Range on Protein: 72-352
Range on HMM: 9-280/317.0
IKAHSANNNAGFIETFTSIRDGLGSAATASRSDANQHLNRYSNIVAYDATRVLVPKNKENFNCDYVNANWIPSEG-PRKYIAAQGPVPASLVSFWQMVVE
..   .... .. | |  ...   .  . ..  .|...|||..|. ||..|| .   .. ...||.||....    .||.||.||| | .. .||.|| |
lldllksdftalleefedllslkldtysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyvdgpnlkrkfIatqgPlpntvedFwrmvwe

HDARLIVMLTNEIEGGKLKCHRYWPDDNMAKAshpqpvkkvkiGTYIVSFEGEESFPTYVHRKFKLYL-ESGEARDVSQMAYTAWPDHGVPATTKELLGF
.. ..|||||.. | |. ||..|||...  .            |...| . .||  . ...|.....  ...| | | .. ||.||||||| ....|| |
qgvtvivmLteleelgrekcaqYwplgetlty...........gdftvtllseeelagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldf

RLAVKDQLKRLNCTPLIHCSAGVGRTGTFIGLDRYIDRVLSKRDADVLDIVRDMRRARNFMIQFVYLFLVCLDAMDQLEKLLD
  ||...|.. ..  |.|||||||||||||.... ....  ... || ..|. .|..|. ..|    .  . ||. .. |  .
leavrealedpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalleylkrkl

0039614 (Phosphotyrosine protein) phosphatases II 71-345 1.5e-70 233.3 In-house 22-286 (297) alignment
Range on Protein: 71-345
Range on HMM: 22-286/297.0
QIKAHSANNNAGFIETFTSIRDGLGSaATASRSDANQHLNRYSNIVAYDATRVLVPKNKEN-FNCDYVNANWIPSEG--PRKYIAAQGPVPASLVSFWQM
 .. . ||.. .... | .. .   .  . ... .|...|||..|..|| .|| .  ...  ...||.||....     .||.||.||| | .. .||.|
llllekansktllllefeellslkpd.ysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfIatqgPlpetvedFwrm

VVEHDARLIVMLTNEIEGGKlKCHRYWPDDNMakashpqpvkkvKIGTYIVSFEGEESFPTYVHRKFKLYLeSGEARDVSQMAYTAWPDHGVPATTKELL
| |.. . |||||...| |. ||..|||..              . |.. | . ..|  . |..|....   .|| | | .. || ||||||| ... ||
vweqgvtvivmLtklvelgr.kcaqywpeegg............tygdftvtllkvehldgytvrtlevtn.ngesrtvthfqytgwpdhgvppslelll

GFRLAVKDQLKR--LNCTPLIHCSAGVGRTGTFIGLDRYIDRVLSKRDADVLDIVRDMRRARNFMIQFVYLFLVCLDAMD
 |  .|...|..   ..  |.|||||||||||||.... .... .... |||..|. .|..|. ..|    .  . ||. 
eflelvrealaelpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydall

0046845 (Phosphotyrosine protein) phosphatases II 98-344 4.8e-70 231.5 In-house 20-270 (284) alignment
Range on Protein: 98-344
Range on HMM: 20-270/284.0
ATASRSDANQHLNRYSNIVAYDATRVLVPKNKEN-FNCDYVNANWIPS------EGPRKYIAAQGPVPASLVSFWQMVVEHDARLIVMLTNEIEGGKLKC
 ....  .|...|||..|..|| .|| .   ...  ..||.||....         ..|.||.|||.| .. .||.|| |...|.|||||...| |. ||
lsvallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweqnvrvIVmltelvengrekc

HRYWPDDNMAKAShpqpvkkvkiGTYIVSFEGEESFPTYVHRKFKLYLE--SGEARDVSQMAYTAWPDHGVPATTKELLGFRLAVKDQLK--RLNCTPLI
..|||...  .            | ..| .  || ...|..|...|  .  .|| | | .. ||.|||||||.... || |  .|...|.    ... ..
aqYwplegevlty..........gdftvtllseevkddytvrtleltnlgytgesrtvthfhytswpdhgvppspedlleflrlvrellenlpgggpivV

HCSAGVGRTGTFIGLDRYIDRVLSKR---DADVLDIVRDMRRARNFMIQFVYLFLVCLDAM
||||||||||||| ||  ....  ..     |||..|. .|. |..|.| .  .. . .|.
HCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyeal

0043336 (Phosphotyrosine protein) phosphatases II 71-343 4.2e-69 228.4 In-house 10-272 (278) alignment
Range on Protein: 71-343
Range on HMM: 10-272/278.0
QIKAHSANNNAGFIETFTSIRDGLGSAATASRSDANQHLNRYSNIVAYDATRVLVPKNKENFNCDYVNANWIPSEG-PRKYIAAQGPVPASLVSFWQMVV
 ..   .|....... | ....      . ... .|...|||..|..|| .|| .   .. ...||.||....    |||.||.||| | ..  ||.|| 
allelllnlktllllefeellsfkldtysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyvdgynvprkfiatqgPlpetvedFwrmvw

EHDARLIVMLTNEIEGGKLKCHRYWPddnmakashpqpVKKVKIGTYIVSFEGEESFPTYVHRKFKLYL-ESGEARDVSQMAYTAWPDHGVPATTKELLG
|.. . |||||.. | |. ||..|||             . ...|.. | . .||....|..|....    .|| | | .. |..||||||| ... || 
elgvttivmLtelvelgrvkcaqYwp............ggsltygdftvtllkeehlddytvrtlevtnlgdgesrtvthyhylgwpdhgvpeslsllld

FRLAVKDQLKRLNCTPLIHCSAGVGRTGTFIGLDRYIDRVLSKRDADVLDIVRDMRRARNFMIQFVYLFLVCLDA
|  ||...|.  |   |.|||||||||||||.|.. .... . .  |....|...|. |  ..|    .  . .|
flkavrealedsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflyea

0036941 (Phosphotyrosine protein) phosphatases II 77-347 7.1e-69 227.7 In-house 9-276 (297) alignment
Range on Protein: 77-347
Range on HMM: 9-276/297.0
ANNNAGFIETFTSIRDGLGSAA-TASRSDANQHLNRYSNIVAYDATRVLVpknkENFNCDYVNANWIPSEG-PRKYIAAQGPVPASLVSFWQMVVEHDAR
....|.. . | .. . | .   ..... .|...|||..|..|| ||| .    .. ..||.||....  . .||.||.||| | .. .||.|| |.. .
llflalllkefeellpllllgslsvallpenleknRykdilpydhtRVkl....ddegsdYinAsyvdgydlkrkfIatqgPlpntvedFWrmvweqnvt

LIVMLTNEIEGGKLKCHRYWPDDNMAKASHpqpvkkvkiGTYIVSFEGEES--FPTYVHRKFKLYL-ESGEARDVSQMAYTAWPDHGVPATTKELLGFRL
 |||||...| |. ||..|||...     .         | ..| . ..|.  ...|. |.....  ..|| | | .. || ||||||| ....|| |  
vIvmltelvelgrekcaqywpleegeslty.........gdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfie

AVKDQLKR--LNCTPLIHCSAGVGRTGTFIGLDRYIDRVL---SKRDADVLDIVRDMRRARNFMIQFVYLFLVCLDAMDQL
.|...||    .   |.||||||||.||||..|  ....      .  |.|..|. .|. |....| .  .. . .|. .|
lvrkvlkllpsggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallel

0047943 (Phosphotyrosine protein) phosphatases II 77-343 2.2e-68 226.0 In-house 8-267 (273) alignment
Range on Protein: 77-343
Range on HMM: 8-267/273.0
ANNNAGFIETFTSIRDGLGSAA-TASRSDANQHLNRYSNIVAYDATRVLVpknkENFNCDYVNANWIPS-EGPRKYIAAQGPVPASLVSFWQMVVEHDAR
........| |  ...   .   ....  .|...|||..|..|| .|| .    .. ..||.||....  . .||.||.||| | .. .||.|| |...|
llgltllleefelllslkplltysvallpenkdknrykdilpydhsrvkl....gdggsdyinAsyvdgynlkrkfiatqgPlpntvedfwrmvweqnvr

LIVMLTNEIEGGKLKCHRYWPDDnmakashpqpVK--KVKIGTYIVSFEGEESFPTYVHRKFKLYL-ESGEARDVSQMAYTAWPDHGVPATTKELLGFRL
.|||||...| |. ||..|||..          .   ... | ..| . .||....|..|...|.  ..|| | | .. || |||||||.....|| |  
viVmLtelvelgrekcaqYwple..........ggelsltygkftvtllseetkddytvrtleltnlgtgesrtvthfhytgwpdhgvppslesllefie

AVKDQLKR--LNCTPLIHCSAGVGRTGTFIGLDRYIDRVLSKRDADVLDIVRDMRRARNFMIQFVYLFLVCLDA
.|...|.    | . ..||||||||||||| ||  .|..  ..  |||..|. .|. |  |.| .  .. . .|
lvrkalealpsngpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrflyea

subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 66-352 4.3e-68 224.7 In-house 5-284 (318) alignment
Range on Protein: 66-352
Range on HMM: 5-284/318.0
QKLRAQIKAHSANNNAGFIETFTSI-RDGLGSAATASRSDANQHLNRYSNIVAYDATRVLVPKNKENFNCDYVNANWIPSE-GPRKYIAAQGPVPASLVS
..|. ...   .. .  . | .  . |.   .... | ...|.. ||| ||.||| |||.. . ... . ||.|||.|.     ..|||||.|.|  .  
edleshvrrlresGelllseeyerlsrseetvtslkslepvnkaknryanilaydhtrvkLqmlegeegsDyinanyidGyrrkkayiaaqaPlpetieD

FWQMVVEHDARLIVMLTNEIEGGKLKCHRYWPDDNmakashPqpvkkVKIGTYIVSFEGEESFPTYVHRKFKLYL-ESGEARDVSQMAYTAWPDHGVPAT
||.|| | ....|||||.| | || |.|||||...      .      ..|.  |  . | .. .|| |.||.   |. | |.| |  ||.|||.|||. 
fWrmvWeqnsavivmltqeeergkakvhryWPskg......s.....rsygklvvelkeevelsdyvlrefkvtrteeeesrqvrqyhytsWpdegvpes

TKELLGFRLAVKDQLKRLNCTP-LIHCSAGVGRTGTFIGLDRYIDRVLSKRDADVLDIVRDMRRARNFMIQFVYLFLVCLDAMDQLEKLLD
. .|| .   |.   .. . .| ..||||||||||.|| .|  ..|.      ||...|. .|. || |.|    . .. |.. .  .  |
gaslldlvrqvskaqqksgagpivvhCsaGvGrtGvfiavdillerikaealvDvfqtvkqlreqrnlmvqtedqyefiydvllealasgd

DSPc_SM00195 97-345 6.5e-68 224.3 In-house 17-259 (263) alignment
Range on Protein: 97-345
Range on HMM: 17-259/263.0
AATASRSDANQHLNRYSNIVAYDATRVLVPKNKENFNCDYVNANWIPSE-GPRKYIAAQGPVPASLVSFWQMVVEHDARLIVMLTNEIEGGKLKCHRYWP
  | .. ..|.. |||.||. || ||| ..|.... . ||.|||.|  .  ..||||.||| |  . .||.||.|.. ..|||||.| | || ||.||||
etteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlteeeengkekcdrywp

DDNmakashpqpVKKVKIGTYIVSFEGEESFP-TYVHRKFKLYLES-GEARDVSQMAYTAWPDHGVPATTKELLGFRLAVKDQLKRLNCTPLIHCSAGVG
...          .| ..|.. | .  .|. .  .. |...|  |   |.|.| |. |..||||||| .||..| .  ||| . .. . . ..|||||||
ees.........ggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkkskstssgpivVhCsaGvg

RTGTFIGLDRYIDRVLSKRDADVLDIVRDMRRARNFMIQFVYLFLVCLDAMD
|||||. .|  .... .. . |. .||. .|  |  |.|    .|.. .|. 
RtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeail

PTPc_SM00194 97-345 6.5e-68 224.3 In-house 17-259 (263) alignment
Range on Protein: 97-345
Range on HMM: 17-259/263.0
AATASRSDANQHLNRYSNIVAYDATRVLVPKNKENFNCDYVNANWIPSE-GPRKYIAAQGPVPASLVSFWQMVVEHDARLIVMLTNEIEGGKLKCHRYWP
  | .. ..|.. |||.||. || ||| ..|.... . ||.|||.|  .  ..||||.||| |  . .||.||.|.. ..|||||.| | || ||.||||
etteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlteeeengkekcdrywp

DDNmakashpqpVKKVKIGTYIVSFEGEESFP-TYVHRKFKLYLES-GEARDVSQMAYTAWPDHGVPATTKELLGFRLAVKDQLKRLNCTPLIHCSAGVG
...          .| ..|.. | .  .|. .  .. |...|  |   |.|.| |. |..||||||| .||..| .  ||| . .. . . ..|||||||
ees.........ggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkkskstssgpivVhCsaGvg

RTGTFIGLDRYIDRVLSKRDADVLDIVRDMRRARNFMIQFVYLFLVCLDAMD
|||||. .|  .... .. . |. .||. .|  |  |.|    .|.. .|. 
RtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeail

subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 70-344 4.7e-67 221.0 In-house 10-275 (288) alignment
Range on Protein: 70-344
Range on HMM: 10-275/288.0
AQIKAHSANNNAGFIETFTSI-RDGLGSAATASRSDANQHLNRYSNIVAYDATRVLVPKNKENFNCDYVNANWIPSE-GPRKYIAAQGPVPASLVSFWQM
|...  ||.|..|| | . |.   .  .. ||.|   |.. ||| ||..|| .|| . | .|. . ||.||..| .| . .||||.|||.....  ||..
akvakksarnrtgfseeynsLaalektksvtagrlavnakknRyrnilpyDekrvklkkleeeagaDYinasyidgekkkkkyiatqgPladtvndfWel

VVEHDARLIVMLTNEIEGGKLKCHRYWPDDNmakashpqpvKKVKIGTYIVSFEGEESFPTYVHRKFKLYlESGEARDVSQMAYTAWPDHGVPATTKELL
| |...  |||||. .|||| ||..||||..          |... |   |   ...    .|.||. |   ... ... |..|.||||||||. ...||
vyenktstivmltelveggktkCeeYWPdad..........kpknyGsvtvtlveskeledfvlrkllle.kkkteleitqyqylaWpdhgvPeskapll

GFRLAVKDQLKRLNCTPLIHCSAGVGRTGTFIGLDRYIDRVLSKRDADVLDIVRDMRRARNFMIQFVYLFLVCLDAM
...  || . .      ..||||||||||||| ||  ||.| ..   ||...|  .|. |....| .. .  . ...
ellrqvkvanqadtgpiivhCsaGvGrtgtFialdalidaveeedyiDvagtvaklRkqRallvqtlkqYefiyevl

0045098 (Phosphotyrosine protein) phosphatases II 91-343 2.7e-66 219.1 In-house 18-267 (278) alignment
Range on Protein: 91-343
Range on HMM: 18-267/278.0
RDGLGSAATASRSDANQHLNRYSNIVAYDATRVLvpknkenfncDYVNANWIPSEgPRKYIAAQGPVPASLVSFWQMVVEHDARLIVMLTNEIEGGKLKC
. |  |  | .    |...|||..|..|| .||           ||.||..|..  |.|.||.||| |  . .||.|. |.. . |||||...|.|. ||
llgipseitpalylgnldknRykdilpydhsrVk..........dYINAsyidgy.pkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrekc

HRYWPDDNMAKAshpqpvkkvkiGTYIVSFEGEESFPTYVHRKFKLYL-----ESGEARDVSQMAYTAWPDHGVPATT--KELLGFRLAVKDQLKR----
..|||....              | . | .. || ...|..|.....      |..| | | .. |. ||||||| ..  | .| .   ... ||.    
aqywpeggslty...........gdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllasl

---------LNCTPLIHCSAGVGRTGTFIGLDRYIDRVlsKRDADVLDIVRDMRRARNF-MIQFVYLFLVCLDA
          ... |.|||||||||||.....  ....  ..  |.|..|. .|. |.. ..|    .  . ..
llsslllldsggpvlVHCsaGvgRtGtlvaaylmlell..eggvdlleavkelrsqRpglavqnleqyrflyef

0045450 (Phosphotyrosine protein) phosphatases II 73-343 2.3e-65 216.7 In-house 19-299 (307) alignment
Range on Protein: 73-343
Range on HMM: 19-299/307.0
KAHSANNNAGFIETFTSIRDGLG---SAATASRSDANQHLNRYSNIVAYDATRVLVPKNKEN-FNCDYVNANWIPSE---------GPRKYIAAQGPVPA
.   .....|. . | ....         ..... .|...|||..|..|| ||| .   ...  ..||.||...             .||.||.||| | 
llllldfltgllkefekllsvtvfllgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydlkrkfIatqgPlpe

SLVSFWQMVVEHDARLIVMLTNEIEGGKLKCHRYWPDDNMAKASHPqpvkkvkigtYIVSFEGEESFPTYVHRKFKLYL--ESGEARDVSQMAYTAWPDH
.. .||.|. |.. ..|||||...| |. ||..||||..  .  ..          . | . .||  . |..|....    ..|| | | .. ||.||||
tvedFwrmlweqgvtvivmltelvelgrekcaqywPdegeeltygn..........ftvtllseehldgytvrtlevtdldgtgesrtvthfhytgwpdh

GVPATTKELLGFRLAVKDQLKR--LNCTPLIHCSAGVGRTGTFIGLDRYIDRVLSKRD---ADVLDIVRDMRRARNFMIQFVYLFLVCLDA
||| ...||| |  .|.. |..   ..  |.|||||||||||||...  .... .       |.|..|. .|. |  ..|    .  . .|
gvppsfeelldfieevrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyea

subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 66-349 4.1e-64 211.6 In-house 8-284 (319) alignment
Range on Protein: 66-349
Range on HMM: 8-284/319.0
QKLRAQIKAHSANNNAGFIETFTSIRDGLGSAATASRSDANQHLNRYSNIVAYDATRVLVPKNKENFNCDYVNANWIPSE-GPRKYIAAQGPVPASLVSF
|.|. ..||. .. . .. . |  .. .     . .  . |.. |||.||.||| ||| ... ..  . ||.||..| .    .|.||.|.|.   .  |
qeLkerlkalastgetllekefkllkeavndtfdsaskeenkkknryqnilaydrtrvvlseldgvegsdyinasfidgyqerekfiatqaPlentiedf

WQMVVEHDARLIVMLTNEIEGGKLKCHRYWPDDNMakashpqpvkkVKIGTYIVSFEGEESFPTYVHRKFKLYLESGEA--RDVSQMAYTAWPDHGVPAT
|.|| |...  .||||.  | .|.|...|||. |.           .. | .||  | ||    |. ||.||   |.|   |.|..  ||.||||.|| .
WrmvWeeessivvmltklveklkvklkkywpeenf...........eeyGrlivtleeeeeledyiirklklnkkssevetRevkhfqyteWpdhdvPek

TKELLGFRLAVKDQLKRLNCTPL-IHCSAGVGRTGTFIGLDRYIDRVLSKRDADVLDIVRDMRRARNFMIQFVYLFLVCLDAMDQLEK
.. || .   ..   .. .  |. .||||||||||||| ||  ..||      ||  .|. .|  ||.|.|    . .. .|. .  .
atslldllkrirksrektqsgPivvhCsaGvGRtGtfivldamlervkeegvlDvfstvsrlRtqRnimvqrpeqYkfiyealleave

0040439 (Phosphotyrosine protein) phosphatases II 101-343 5.9e-63 208.1 In-house 6-241 (249) alignment
Range on Protein: 101-343
Range on HMM: 6-241/249.0
SRSDANQHLNRYSNIVAYDATRVLVPKNKENFNCDYVNANWIPSE-GPRKYIAAQGPVPASLVSFWQMVVEHDARLIVMLTNEIEGGKLKCHRYWPDDNM
..  .|...|||..|..|| .|| .   .. | .||.||..|.    .|..||.||| | .. .||.|. |.. . |||||.. | |. ||..|||....
allpenkdknrypdilpydhsrvklsilpglflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywplggs

AKAshpqpvkkvkiGTYIVSFEGEESFPTYVHRKFKLYL-ESGEARDVSQMAYTAWPDHGVPATTKELLGFRLAVKDQLKR--LNCTPLIHCSAGVGRTG
 .            |.. | .  .|... |..|...|.  . || | | .. || ||||||| ....|| |  ||.. |..   ..  |.||||||||||
ley...........gdftvtllsvevkddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtG

TFIGLDRYIDRVLSKRDADVLDIVRDMRRARNFMIQFVYLFLVCLDA
|||...  ....  ... |....|...|..|. ..|    .  ...|
tfiaaylmleqlekelgvdleeavkllrsqRpgavqnpeqyrflyea

0042113 (Phosphotyrosine protein) phosphatases II 101-343 2e-62 206.1 In-house 4-238 (245) alignment
Range on Protein: 101-343
Range on HMM: 4-238/245.0
SRSDANQHLNRYSNIVAYDATRVLVPKNKENFNCDYVNANWIPSEG-PRKYIAAQGPVPASLVSFWQMVVEHDARLIVMLTNEIEGGKLKCHRYWPDDNM
..  .|...||||.|..|| ||| ..  .... .||.||....    ..|.||.||| | ..  ||.|. |.. . |||||.| | |. ||..|||....
allpenkdknrysdilpydhtrvklspdggdldsdyinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywplges

AKAshpqpvkkvkiGTYIVSFEGEESFPTYVHRKFKLYL-ESGEARDVSQMAYTAWPDHGVPATTKELLGFRLAVKDQLK-RLNCTPLIHCSAGVGRTGT
 .            |...| . .||....|..|....    ..| | | .. |. ||||||| ... || |  .|...|.   | . |.|||||||||||
lty...........gdftvtllseehlddytvrtlevtnlgddesrevihyhylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGt

FIGLDRYIDRVLSKRDADVLDIVRDMRRARNFMIQFVYLFLVCLDA
||.... .... . .. .. ..|...|. |  ..|    .  . .|
fiaaylmleqlekelgvsleeavkelrsqRpgavqtpsqyrflyea

Y_phosphatase Protein-tyrosine phosphatase 106-344 9.9e-62 203.8 Pfam-A 1-233 (235) alignment
Range on Protein: 106-344
Range on HMM: 1-233/235.0
NQHLNRYSNIVAYDATRVLVpkNKENFNCDYVNANWIPSE-GPRKYIAAQGPVPASLVSFWQMVVEHDARLIVMLTNEIEGGKLKCHRYWPddnmakash
|.. |||..|..|| ||| .  .... ..||.|||.. .   ..|.||.|||.. .. .||.||.... ..|||||.. | |. ||..|||         
nkkknRykdilpydktrvkl..kgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwp.........

P---QpvkKVKIGTYIVSFE-GEE-SFPTYVHRKFKLYLESGEA--RDVSQMAYTAWPDHGVPATTKELLGFRLAVKDQLKRLNCTPLIHCSAGVGRTGT
    .   ... |.. |  .  |.     |. ||..|  . .|   | |.|. ||.|||||||...|.|| .  .|. . .  .   ..|||||||||||
eeeee...sltygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgt

FIGLDRYIDRVLSKRDADVLDIVRDMRRARNFMIQFVYLFLVCLDAM
|. ||  .... .... |||.||. .|. |. |.| .  . .. .|.
fvaldilleqleaeeevdvlqivkelRkqRpgmvqsleqYiflykai

Y_phosphatase Protein-tyrosine phosphatase 106-344 9.9e-62 203.8 In-house 1-233 (235) alignment
Range on Protein: 106-344
Range on HMM: 1-233/235.0
NQHLNRYSNIVAYDATRVLVpkNKENFNCDYVNANWIPSE-GPRKYIAAQGPVPASLVSFWQMVVEHDARLIVMLTNEIEGGKLKCHRYWPddnmakash
|.. |||..|..|| ||| .  .... ..||.|||.. .   ..|.||.|||.. .. .||.||.... ..|||||.. | |. ||..|||         
nkkknRykdilpydktrvkl..kgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwp.........

P---QpvkKVKIGTYIVSFE-GEE-SFPTYVHRKFKLYLESGEA--RDVSQMAYTAWPDHGVPATTKELLGFRLAVKDQLKRLNCTPLIHCSAGVGRTGT
    .   ... |.. |  .  |.     |. ||..|  . .|   | |.|. ||.|||||||...|.|| .  .|. . .  .   ..|||||||||||
eeeee...sltygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgt

FIGLDRYIDRVLSKRDADVLDIVRDMRRARNFMIQFVYLFLVCLDAM
|. ||  .... .... |||.||. .|. |. |.| .  . .. .|.
fvaldilleqleaeeevdvlqivkelRkqRpgmvqsleqYiflykai

subfamily_PTPN3_pd Subfamily PTPN3 93-338 1.4e-60 199.6 In-house 28-265 (280) alignment
Range on Protein: 93-338
Range on HMM: 28-265/280.0
GLGSAATASRSDANQHLNRYSNIVAYDATRVLVPKNKEnfncDYVNANWIPSEGPR-----KYIAAQGPVPASLVSFWQMVVEHDARLIVMLTNEIEGGK
  | | .|.|  .| . ||| .|..|||||| . ...     ||.|||..  | |      .|||.|||.. .   ||||| |....||||||. .| |.
kpglaisaarkpenlsknryrdilpydatrvklkeset....dyinanyvnmeipstglvnryiatqGPlaktatdfWqmvweqksslivmlttlverGr

LKCHRYWPDDNmakashpqpvKKVKIGTYIVSFEGEESFPTYVHRKFKLYLES-GEARDVSQMAYTAWPDHGVPATTKELLGFRLAVKDQLKRLNCTPLI
 |||.|||. .          .... |.. |  | |..  .|| |.. |  ..  | | . |. |.||||||||  ....| |   |... .  .   ..
vkChqyWPete..........deleygefsvkcekedetksyvlrelvlkdketkeerkilqlqylaWpdhgvPddsadflefvervrklrsgkeePvvv

HCSAGVGRTGTFIGLDRYIDRVLSKRDADVLDIVRDMRRARNFMIQFVYLFL
|||||.|||| .| |.  .  . ....  .||||| ||  |  ..| .  . 
hCsaGigrtGvlilletalalieaaepvypldivrtmrdqramlvqtasqyk

subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 70-340 1.4e-59 196.8 In-house 16-282 (298) alignment
Range on Protein: 70-340
Range on HMM: 16-282/298.0
AQIKAHSANNNAGFIETFTSIRDGLG----SAATASRSDANQHLNRYSNIVAYDATRVLVPKNKENFNCDYVNANWIPS-EGPRKYIAAQGPVPASLVSF
   . . ... .|. . |  .. .         ...|...|.. |||..|.|.| .||.. |.... ..||.|| .. . .|   .||.|.|...... |
klaavkkkkkltgyalefqrlnsvsseieeeekevarkpenkkkNRyadiialdssRvvLekedadeesdYiNAsflhaykgrnafiatqaPltetvedF

WQMVVEHDARLIVMLTNEIEGGKLKCHRYWPDDNMAKASHPQPvkkvkigtyivSFEGEESFPTYVHRKFKLY-LESGEARDVSQMAYTAWPDHGVPATT
|.||.|.|.  ||||||  | .|.|.|.||||.. ..  . .            |   .|.|  .. ||.|.   .. . | | |. .| |||.|||...
WrmvteedigtiVmltnleeldktkyhkywPdegketygeitv...........sllskeefadlivrklkvskkkeekerevrqlhftsWpdkgvpena

KELLGFRLAVKDQLKRLNCTP-LIHCSAGVGRTGTFIGLDRYIDRVLSKRDADVLDIVRDMRRARNFMIQFVYLFLVC
. .|...  |. . ..   .| ...|||||||.|||| .|  ..||  ..  ||...|. .|. |  ..|    .  .
tsvldllrkvrasqqqagnkpvivqCsaGvgRsGtfiaidsvlervkkeqvvDvfqvvkvlRkkrpgavqteeqYvfi

subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 67-347 5e-59 194.9 In-house 8-282 (305) alignment
Range on Protein: 67-347
Range on HMM: 8-282/305.0
KLRAQIKAHSANNNAGFIETFTSIRDGlGSAATASRSDANQHLNRYSNIVAYDATRVLVPKNKENFNCDYVNANWIPS-EGPRKYIAAQGPVPASLVSFW
.| |.|| ...... |. . . |. .  ...    ...||.. ||...|. .|  |. . ..... . ||.||... . ..  |||.||||..  .. ||
dlaayikearvysdkgleaqykslyee.eesidvgkkeankaknrlkeitlldddriiltekeslddsdyinasyvdgykrkkkyivaqgPlkntvadfW

QMVVEHDARLIVMLTNEIEGGKLKCHRYWPDDNMakasHpqpvkKVKIGTYIVSFEGEESFPTYVHRKFKLYL--ESGEARDVSQMAYTAWPDHGVPATT
...||   . |||||. .|||| ||..|||.       .     |...| ..|  . |.... |. ||.|.    |. | | |.|.  | ||||||| ..
rliveekvstivmltklveggkdkCrqYWpeskt....e.....kkefgefsvelksektasdyieRklkisiededkesrtvlqyqltdWPdhGvpqfa

KELLGFRLAVKDQLKRL-NCTPLIHCSAGVGRTGTFIGLDRYIDRVLSKRDADVLDIVRDMRRARNFMIQFVYLFLVCLDAMDQL
  || .   |. . |.  . . |.||||||||||.|| .|  ..|.      || .... .|. |  |.|    .  . ||.|.|
tsllslikrvqkdqkkdkgvpllVhCsagvgRtGvfiavdialerlkkEevvdvfevlkqlRskrmkmvqtldqYvflhdaldel

subfamily_PTPN12_pd Subfamily PTPN12 98-337 1.1e-58 193.4 In-house 32-266 (290) alignment
Range on Protein: 98-337
Range on HMM: 32-266/290.0
ATASRSDANQHLNRYSNIVAYDATRVLVPKNKENFNCDYVNANWIP-SEGPRKYIAAQGPVPASLVSFWQMVVEHDARLIVMLTNEIEGGKLKCHRYWPD
..|.... |.. ||| .|. || .|| . |..|. . ||.|||.|  .||. .|||||||.|. |  ||.|. |.. ...||. .|.| || ||.||||.
teagekeenvkknrykDilPydksrvelskieeeegsdYinanfikgvegkleyiaaqgPLpktlddfWrmiweknveivvmaCrevelgkkkCerYWpe

DNMakashpqpvKKVKIGTYIVSFEGEESFP-TYVHRKFKLYLEsGEARDVSQMAYTAWPDHGVPATTKELLGFRLAVKDQLKRLNCTPLIHCSAGVGRT
 .          .....|.. |. | |. .   .. | .|.  . .| | | |. ||||||||||...|.|| .  .|..  .. .   ..|||||||||
ege.........eelefgefevtleeekavdddflirtLkveaq.kesrkvyqfhYtaWPDhgvPssaksllelielvrelqesedaPlvvhCsaGvGrt

GTFIGLDrYIDRVLSKRD----ADVLDIVRDMRRARNFMIQFVYLF
|| | .| |. ..| ..      || |.|...|. |. ..|    .
Gtiiaid.yvrellkaekipeeldvfdlvlelrkqraalvqtkeqy

subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 105-339 5.1e-58 191.2 In-house 19-255 (270) alignment
Range on Protein: 105-339
Range on HMM: 19-255/270.0
ANQHLNRYSNIVAYDATRVLVPKNKENFNCDYVNANWIP--SEGPRKYIAAQGPVPASLVSFWQMVVEHDARLIVMLTNEIEGGKLKCHRYWPDdnmaka
 ...|||| .|.   |||| ... .|. .  |.|||...  .. ..|||||.||.|..| |||.|..|. .. |||.|.  | |. || ||||       
rgkklnRyadiLPsPatRvrleeleedsataYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkgrkkCerYWpa......

sHPQPVKKVKIGTYIVSFEGEESFPTYVHRKFKLYlESGEARDVSQMAYTAWPDHGVPATTK------ELLGFRLAVKDQLKRLNCT--PLIHCSAGVGR
 .|.   |.. |.  |  . ||    |. .. .|  |.|| | .    |..||||||| ..       .||    ||. . |.|. .   |.||||||||
.epkekvkledgkikvlalseekeegyiltrlrle.ekgeerrlvHfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkaePllvHcsaGvgR

TGTFIGLDRYIDRVLSKRDADVLDIVRDMRRARNFMIQFVYLFLV
|||.| ||  .  . ... .||| |....|. |  ..| .  .  
tGtlialDiavrlLeetkkvdvlaiieelRkdRmalvqhpeqyef

0037934 (Phosphotyrosine protein) phosphatases II 101-343 8.1e-58 191.2 In-house 5-237 (243) alignment
Range on Protein: 101-343
Range on HMM: 5-237/243.0
SRSDANQHLNRYSNIVAYDATRVLVpknkENfnCDYVNANWIPSEgPrKYIAAQGPVPASLVS----FWQMVVEHDARLIVMLTNEIEGGKLKCHRYWPd
... .|.. ||||.|..|| .|| .    |.  .||.|||.|.   | ..|| ||| | .. .    ||.|. |.. . |||||...| |..||..||| 
allpenlsknrysdilpydhsrvkl....eg..sdyinanliyvt.p.rliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywp.

dnmakashpqpvKKVKIGTYIVSFEGEESFPTYVHRKFKLYL--ESGEARDVSQMAYTAWPDHGVPATTKELLGFRLAVKDQLKR--------LNCTPLI
             .| .|...| . .||... |..|...|.   .... | | .  |..||||||| ... || |  .|.. ...         . . |.
............gevtygdftvtllseehlddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlV

HCSAGVGRTGTFIGLDRYIDRVlskrDADVLDIVRDMRRARNF-MIQFVYLFLVCLDA
|||||||||||.| ..  ....    . |....|...|. |.. ..|    .  . .|
HCsaGvgRtGtliaaylmllll....gvdleeavkllreqRpgkavqtpsqyrflyea

subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 72-342 9.6e-58 190.6 In-house 15-283 (315) alignment
Range on Protein: 72-342
Range on HMM: 15-283/315.0
IKAHSANNNAGFIETFTSIRDGLGSAATASRSDANQHLNRYSNIVAYDATRVLVPKNKENFNCDYVNANWIPS-EGPRKYIAAQGPVPASLVSFWQMVVE
.  . |. . || . . ||  |       ..   |.. ||| ||.||| .|| .|  . . ..||||||.|.  . .|.||||||| .||.  ||..| |
vaqkkastkngfkqdyesipggqlhpldvakkienkqknryiniiaydksrvqlpllendphsdyvnanfidGynkkrryiaaqgpnvasvkdfwrlvfe

HDARLIVMLTNEIEGGKLKCHRYWPDDnmakashpqpvkKVKIGTYIVSFEGEESFPTYVHRKFKLYLESgEARDVSQMAYTAWPDHGVPATTKELLGFR
.|   |||||| .|| | |. .||||.            ||  | . |.   || .  |  | .    .. . |.| |. ||.||| |||. |  |. . 
edigkivmltnlvegekrkaekywpdk............kviyGkitvtrkseevnteytvrtlsvvfgd.nirevvqlhytswpdmgvpkytiplmnli

LAVKDQLKRLNCTPLIHCSAGVGRTGTFIGLDRYIDRVLSKRDADVLDIVRDMRRARNFMIQFVYLF------L----VCLD
  ||   .   .. ..||||||||||||| ||  .|..  ..  || .... .|. |  |.| .  .      |    || |
rtvkqhhtnsvgaivvhcsaGvGrtGtfitldavldqaeaenaidvynfitgvrqnrikmvqvaeqyqfiydalletfvcgd

subfamily_PTPN6_pd Subfamily PTPN6 70-334 1.8e-57 189.7 In-house 15-283 (306) alignment
Range on Protein: 70-334
Range on HMM: 15-283/306.0
AQIKAHSANNNAGFIETFTSIRDGLgSAATASR----SDANQHLNRYSNIVAYDATRVLVPkNKENFNCDYVNANWIPSE---GPRKYIAAQGPVPASLV
   | ..  ..||| | | ...    .  . ||       |.. ||| ||. .| ||| .  ...  . ||.||| | .|     ..|||.|| ... . 
elekeeeslekagfeeefeelqqee.akkllsrkegakpenkeknryknilPfDhtrvilk.epsvpgsdyinanyikkevkgsdksyiatqgclettvs

SFWQMVVEHDARLIVMLTNEIEGGKLKCHRYWPDDNMAKAsHpqpvkkvkiGTYIVSFEGEESFPTYVHRKFKLY--LESGEARDVSQMAYTAWPDHGVP
 ||.||.. ..|.|||.|.|.| || || ||||| .. .. .         |.. |.   |.|  .|. |....    ...|.|.| |. ...|||||||
dFWrmvwqensrvivmttkevErgkekCarYWPdeeekee.y.........GkisvtnvseksladYilRelsvskkkkkkeerevfqyhfksWPdhgvp

ATTKELLGFRLAVKDQLKRLN---CTP-LIHCSAGVGRTGTFIGLDRYIDRVLSK---RDADVLDIVRDMRRARNFMIQFV
. .. .| |   |. . ..|.     | ..|||||.||||||| .|  .. . .|    | |. ..|. .|. |. ..|  
kdpgavLdfledvnrkqeeleeaeagpivvhCsaGiGRtGtfiviDillkliekkgldadidiqklvksvreqrsglvqte

subfamily_Ptp69D_pd Subfamily Ptp69D 66-344 8.6e-57 187.6 In-house 7-282 (307) alignment
Range on Protein: 66-344
Range on HMM: 7-282/307.0
QKLRAQIKAHSANNNAGFIETFTSIR-DGLGSAATASRSDANQHLNRYSNIVAYDATRVLVPKNKENFNCDYVNANWIPSE-GPRKYIAAQGPVPASLVS
..|. ..|..  . . |... . ..        ...|  . |.  ||| .|.|.| ||| ..| . . . ||.||..| .    .|.||||.|| | .  
ddleealksrkrdtdfglakeyekLeareidkstkvsekkenalknRyedikafDktRvkLkkingkedsdYinasfikgykekkkfiaaqdPveatigD

FWQMVVEHDARLIVMLTNEIEGGKLKCHRYWPDDnmakashpqpvKKVKIGTYIVSFEGEESFPTYVHRKFKLYLES------GEARDVSQMAYTAWPDH
||.|. | .  |||||.|. |  . ||..|||..           ..|. |  .| .  ||. . |..|....           . | | |  ||.|.| 
fWRmiaeqevtlivmlsnlteknrkkcakYWpie...........devqygdilvklvseekhsdyiiReldvskkkeesgevedsrkvvqyhytgWkDs

GVPATTKELLGFRLAVKDQlKRLNCTP-LIHCSAGVGRTGTFIGLDRYIDRVLSKRDADVLDIVRDMRRARNFMIQFVYLFLVCLDAM
 || ... || .   |..  ..|| .| ..||||||||.|.|. ||  ....     .|. ..|.|.|. ||...|    .  .  |.
kvPevargllklieqvrel.yklnrsPivvhCsaGvgrsgifvaldsllqqlkaedkvdifetvkdLrsqRnllvqsleqYvflyral

subfamily_PTPN13_pd Subfamily PTPN13 98-344 1.1e-56 187.1 In-house 29-265 (273) alignment
Range on Protein: 98-344
Range on HMM: 29-265/273.0
ATASRSDANQHLNRYSNIVAYDATRVLVPKNKEnfncdYVNANWIP---SEGPRKYIAAQGPVPASLVSFWQMVVEHDARLIVMLTNEIEGGKLKCHRYW
.. .....|.. ||| |.. ||.||| . ..       |.||..|     .   .|||.|||.| .   ||||| | .|..|.|.|.| |.||.||||||
cevgkkkenkdknryrnvlPydetrvklgdegg.....yinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweqkaeviamvtlekekgkvkchryw

PDDNMakashpqpvKKVKIGT-YIVSFEGEESFPTYVHRKFKLY-LESGEARDVSQMAYTAWPDHGVPATTKELLGFRLAVKdQLKRlNCTP-LIHCSAG
|. .          ||.|.   . |. .. .   ..| |....  .||||.|.|... ...|||||||....||| |   |. .|.. . .| ..|||||
Peskn.........kklkvsnrlevellkvqkldgfvvralavkdsesgesrevahlnfvkwPdhgvPssaaellqfvaevr.rlqt.dagPivvhcsaG

VGRTGTFIGLDRYIDRVLSKRDADVLDIVRDMRRARNFMIQFVYLFLVCLDAM
.||.||.| .|  .. .  ... || .|||..|. |. ..|    .. .  |.
iGrsGtlitidvvlglierdkefdvkeivrklreqrqgvvqtkdqyifvykai

subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 101-345 3.6e-55 181.9 In-house 4-243 (250) alignment
Range on Protein: 101-345
Range on HMM: 4-243/250.0
SRSDANQHLNRYSNIVAYDATRVLVPKNKENFNCDYVNANWIPS-EGPRKYIAAQGPVPASLVSFWQMVVEHDARLIVMLTNEIEGGKLkCHRYWPDDNM
..  .|.. |||..|.|.| .||.. |.| . ..||.|| .. . .. . .||.|||..|... ||.||.|...  ||||||  | .|  .|.||| .. 
akkpqnkeknryadiialdssrvvLekekgdkesdyinasflhgyderkafiatqgPlqatiedfWrmvleeksgtivmLtnLkesekt.yhqywPveka

AkashpqpvkkvKIGTYIVSFEGEESFPTYVHRKFKLYLESGE-ARDVSQMAYTAWPDHGVPATTKELLGFRLAVKDQLKRLNCTPL-IHCSAGVGRTGT
            | |   ||   .| |  |..||.||  .. .  | | |. ...||| |||....  |...  |. . .. . .|. ..|||||||.|.
e...........kyGdvtvsllskeefadytkrklklskakkaderivrqlhfvvWPdkgvPevatavLellkkvqasqqqagnaPvivqCsaGvgrsGa

FIGLDRYIDRVLSKRDADVLDIVRDMRRARNFMIQFVYLFL----VCLDAMD
|| .|  ..|.  ..  || .... .|. |  ...    .     . | |.|
fiaidavlerlkkekvvdvfkvikvlrkdrphavesleqyvfvyeiilkald

subfamily_PTPRA_pd Subfamily PTPRA 66-347 4.1e-54 178.7 In-house 17-294 (330) alignment
Range on Protein: 66-347
Range on HMM: 17-294/330.0
QKLRAQIKAHSANNNAGFIETFTSIRD-GLGSAATASRSDANQHLNRYSNIVAYDATRVLVPKNKENFNCDYVNANWIPSE-GPRKYIAAQGPVPASLVS
.||  .|. .||..|  | | | ..    . ..  ..  . |.. ||. ||. || .|| ... . . . ||.|| .|       |.||||||   ..  
ekleeeirirsaddnklfreefnalPagpiqatlelaskeenkeknrvvnilPydfsrvilsvkeGveesdyinasfidGykekdkfiaaqGPkeetved

FWQMVVEHDARLIVMLTNEIEGGKLKCHRYWPDDNMakashpqpvkkVKIGTYIVSFEGEESFPTYVHRKFKLY-----LESGEARDVSQMAYTAWPDHG
||.|. |...  |||||.  |  . ||..||||. .           |  |   |. | |.    |  ||| .       .  ..| |.|. .|.||| |
fwrmiweqksativmltelkerkeekcaqywPdeGl...........vtyGnirvevedetvlvdytvrkflvqqlpdatrekksrlvrqfhftswPdvG

VPATTKELLGFRLAVKDQLKRLNCTPLIHCSAGVGRTGTFIGLDRYIDRVLSKRDADVLDIVRDMRRARNFMIQFVYLFLVCLDAMDQL
||.... .| .  .|| . ..   .  .||||||||||||| ||  ..|| ..|  || ..|. .|  |  |.|    .  .  .. . 
vPfepiGmlkllkkvkklnqqsagpivvhcsaGvGrtGtfivldavlervkaerkvdvfefvkrlrlqrpqmvqtdeqyefiykvlley

subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 79-334 6.7e-54 177.8 In-house 17-263 (315) alignment
Range on Protein: 79-334
Range on HMM: 17-263/315.0
NNAGFIETFTSIRDGLGSAATASRSDANQHLNRYSNIVAYDATRVLVPKNKENFNCDYVNANWIPSEGP-RKYIAAQGPVPASLVSFWQMVVEHDARLIV
. | | | |  . |   .  ...| . |.. ||| ||. .| .|| .    .. . ||.||  |.|    . |||.||| .||.  ||.||.....  ||
htalfseefhdlpdPdiyrqrvaretinfkknryknilPldsarvkleviddsPdsdyinasyiksvdddkayiasqgPlkasvddfwrmvlqekvttiv

MLTNEIEGGKLKCHRYWPDDNmakAshpqpvKKVKIGTYIVSFEGEESFPTYVHRKFkLYLESGEARDVSQMAYTAWPDHGVPATTKELLGFRLAVKDQL
|.|.  || |.|| .|||| .   |      . |. |.. |.    |.    |.||.    .| | | |.|  .| |||.||.  |  || .  .|| . 
mvtkkqegdkikcrqywPdrk...a......dsvefGsikvellsleadtdgvarkl.vtrkseesrtvtqfqftewPdkGvdkqtssllklikevkadn

KRLNCTPLIHCSAGVGRTGTFIGLDRYIDRVLSKRDADVLDIVRDMRRARNFMIQFV
.. . . |.|||||||||| .| .|  ....  .|  ||...|. .|. | ...|  
gkkefsllvhcsaGvGrtGvvisidevvaqikrtrsvdvfnfvknlrakrpylvqte

subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 83-333 1.1e-53 177.1 In-house 20-261 (515) alignment
Range on Protein: 83-333
Range on HMM: 20-261/515.0
FIETFTSIRDGLGSAATASRSDANQHLNRYSNIVAYDATRVLVPKNKENFNCDYVNANWIPSEGP-RKYIAAQGPVPASLVSFWQMVVEHDARLIVMLTN
| | |  .        | .. . | . ||| ||. || .|| .   ..| . ||.||  |||    . |||.||| .||.  ||..|....   |.|.|.
fseefhdlpgpniypqtvaqeeinfkknryknilPydsvrvklevindnPhsdyfnasyipsfdndkayiasqgPnkasvddfWrlvlqenvttiamvtk

EIEGGKLKCHRYWPDdnmakashpQPVKKVKIGTYIVSFEGEESFPTYVHRKFKLYLESGeARDVSQMAYTAWPDHGVPATTKELLGFRLAVKDQLKRLN
  || | || .||||         .| . || |.. |.    |.    . ||...  ..  .| | |  .| |||.|||  |. || .  .|| .  ...
lkegdkikcgkyWPd.........kpgdsvkfGsikvelvsleactggikrkltvlkgdd.srtvtqfhfteWPdkGvpkhtssllklikevkadhgqyt

CTPLIHCSAGVGRTGTFIGLDRYIDRVLSKRDADVLDIVRDMRRARNFMIQF
 . .||||||||||| .| .|  . ..   |  ||...|. .|. | ...| 
hpliihcsaGvGrtGvvisidsvvahakttrmvdvfnfvtnirqkrpylvqt

subfamily_PTPN9_pd Subfamily PTPN9 77-343 3.5e-53 175.6 In-house 12-285 (297) alignment
Range on Protein: 77-343
Range on HMM: 12-285/297.0
ANNNAGFIETFTSIRDGL-GSAATASRSDANQHLNRYSNIVAYDATRVLVPKNKENFNCDYVNANWIPS-EGPRKYIAAQGPVPASLVSFWQMVVEHDAR
.... | .. .. ||.      ..||.. || . |||.... || ||| ..| .|. . ||.|||..   . .. .||.|||..     ||.|| |....
ekgkrGlskeyaeirnepveGtflasklranleknrytdvlcydetrvvlakvdedeasdyinanfvdGykqkkafiatqGplkktvsdfWrmvWeqevl

LIVMLTNEIEGGKLKCHRYWPDDNMAKASHpqpvkkvkiGTYIVSFEGEESFPTYVHRKFKLY-LESGEARDVSQMAYTAWPDHGVPATTKELLGFRLAV
 ||| |  .| |.||| .|||... . |..         | . ||    |.   |..|.....  . .| | |.   ...|||.||| ....|| .. .|
vivmttrvvergrlkcgqyWpleeessaef.........gdlsvsnveveeeedykvrvleiknvkteesrkvthfqflsWPdyGvPssaaslldvlekv

KDQLK------------RLNCTP-LIHCSAGVGRTGTFIGLDRYIDRVLSKRDADVLDIVRDMRRARNFMIQFVYLFLVCLDA
...              ...  | ..|||||.||||||| ||  ..|. ..  .|| . |. .|  | |.||    .  |  |
rekqalavkelgdewkghpsgPPivvhcsaGiGrtGtfitldiclsrleevgtvdvvetvkllrtqrafsiqtpeqyefcyla

subfamily_PTPRG_pd Subfamily PTPRG 69-347 2.7e-51 169.5 In-house 7-290 (563) alignment
Range on Protein: 69-347
Range on HMM: 7-290/563.0
RAQIKAHSANNNAGFIETFTSIRDGLGSA---ATASRSDANQHLNRYSNIVAYDATRVLVPKN-KENFNCDYVNANWIPS-EGPRKYIAAQGPVPASLVS
   . .  |... || | | ..     |    |..|.   |.. |||.|||||| .|| . .   .. . ||.|||.|   .  ...||.|||..  .  
akhvaslhadgdigfseefealqsetiskdldaehsqkpenkrKnRylnivaydrsRvklsplpgkkkklDYinAnyidGyqkskafiatqgplkdtfdd

FWQMVVEHDARLIVMLTNEIEGGKLKCHRYWPDDNMAKASHPQpVKKVKIGTYIVSfeGEESFpTYVHRKFKLYLESGEARDVSQMAYTAWPDHGVPATT
||.|. |. . .|||.||  | |. ||..||| |.  .  . | |. ..  . ...   .... .  ..| |   .  . . | |  || |||||||  .
FWrmiWeqnvaiivmitnlvergrrkcdvYWPkdesetygalq.vtlieeevlaly..tvrtl.viknlklkkkkqcdteklvrqyhytkWPdhgvPehs

KELLGFrLAVKDQLKRLNCTPL-IHCSAGVGRTGTFIGLDRYIDRVLSKRDADVLDIVRDMRRARNFMIQ----FVYLFLVCLDAMDQL
   | |    ... .. .  |. .|||||||||||.| ||  . .. ..   .|..... .|  |||..|    ...|. . |.|.   
lpvLif.vkkssaankaeaGPivvHcsaGvgrtGtyivldtllkqiqqenavnvfgflkhiraqRnflvqteEqYiflhdalleaiask

subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 70-346 2.9e-51 169.1 In-house 9-285 (290) alignment
Range on Protein: 70-346
Range on HMM: 9-285/290.0
AQIKAHSANNNAGFIETFTSIRDGLGS-AATASRSDANQHLNRYSNIVAYDATRVLVPKNKENFNC--DYVNANWIPS-EGPRKYIAAQGPVPASLVSFW
  .  . |..| || . |...  |  . ..|   .  |..|||..||| ||  |. . .  .. .|  .|.|| .|   .  ..|||.||||.  || ||
efvanghakgnegfrnqfkmldsgesehtvtvgltssnkllnRfanivvyddnritLrpisghkDCtneyinAcyikgykekkqyiatqgpvsntlvdFW

QMVVEHDARLIVMLTNEIEGGKLKCHRYWPDDNMAKaSHPQPVKKvkigtyivsfEGEESFPTYVHRKFKLYLESG--EARDVSQMAYTAWPDHG-VPAT
.......   ||||||.|| || ||. |||| . ..   .  .|             ||.. .|..||...  ..   ... | |   |.|...| |...
kliwqekvtiivmltniieegkvkCqqYWpdsdtka.ygefsikl..........lneetlneyierklevknknsagakqsvtqyqitnwdstgkvtnp

TKELLGFRLAVKDQLKRLNCTPLIHCSAGVGRTGTFIGLDRYIDRVLSKRDADVLDIVRDMRRARNFMIQFVY----LFLVCLDAMDQ
.  || ..  .| | || |   ..|||..|||...|. ..  |... ..   ||..... .|  .  ..| |     .| . | ..|.
qtillvieemyktqrkrgntsivvHCSdtvgrsavfcaaattinkcktegvidvfqvlksqRiqkpgsvqtvqqyqgifqivltylds

subfamily_PTPRK_pd Subfamily PTPRK 71-344 1.8e-50 166.5 In-house 12-273 (314) alignment
Range on Protein: 71-344
Range on HMM: 12-273/314.0
QIKAHSANNNAGFIETFTSIRDGlgsaATASRSDANQHLNRYSNIVAYDATRVLVPKNKENFNCDYVNANWIPS-EGPRKYIAAQGPVPASLVSFWQMVV
.|.   .... || | . |. .|      |.. | |.. ||. .|.||| .|| .   ... . ||.||..| | . |...|..|||..  .  ||..| 
siallkraegygfkeeyeslfeg....wdaakkdenreknrsgdilaydrsrvflitidgdpssdyinaalidsykrpaafivtqgPlqetvkdfWrlvy

EHDARLIVMLTNEIEGGKLKCHRYWPDDNMAkasHpqpvKKVKIgtYIVSFEGEESfptYVHRKFKLYL---ESGEARDVSQMAYTAWPDHGVPATTKEL
....  |||||. .| |..|| .|||.| .    .    ...|.   .|. | ..    .|.| |...       | | | |. ...||||.||   . |
dencasivmltelvevgrvkClkyWPedtev...y....gdikv..elvetellae...lvvrifrveklargqeeirevrqfqflgWpdhdvPvsatgl

LGFRLAVKDQLKRLNCTPLIHCSAGVGRTGTFIGLDRYIDRVLSKRDADVLDIVRDMRRARNFMIQFVYLFLVCLDAM
|..   || . .  .   ..||||| ||||||| .|  .| .  ..  ||  .|...|  .  |..    .  . |..
lklvrrvkksqeeeaGrivvhCsaGaGrtGtfiaidivldmieregvvdvfnavktlrsrkvnmveteeqykfiydvi

subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 71-346 4.3e-50 165.7 In-house 13-286 (325) alignment
Range on Protein: 71-346
Range on HMM: 13-286/325.0
QIKAHSANNNAGFIETFTSIRDGLGSAATASRSDANQHLNRYSNIVAYDATRVLVPKNKENFNCDYVNANWIPSE-GPRKYIAAQGPVPASLVSFWQMVV
... . |... ||   |  .    | | ...   .|.  ||. |.||.| .|| .   |.. ..||.||... .. .   ..||| | .|..  .|..|.
hvekkkaqdqdgfahefgllpsddgiakkvamkpenkaknrfknvvaldksrvvletkkddpssdyinasylrddkkkdvflaaqaPltatindlWrlvl

EHDARlIVMLTNEIEGGKLKCHRYWPDDnMAKAshpqpvkkVKIGTYIVSFEGEESFPTYVHRKFKLY-LESGEARDVSQMAYTAWPDHGVPATTKELLG
.  .  .|...||...|| .|  |||.. |.|.        .. |.  |..   | .  ||||....   . ||.| | |. . .|.| ||.     |. 
dWrcs.vvvvlneldlgkdrcavywpke.mgks........ktfGglevklrtieeisdyvhrvldvkqvkkGetrsvkqfqlqswddmGvqkrpatlis

FRLAVKDQLKRLNC-----TP-LIHCSAGVGRTGTFIGLDRYIDRVLSKRDADVLDIVRDMRRARNFMIQFVYLFLVCLDAMDQ
.   ||   .|...     || |.||||||||||.|| |   ...|. .   |... |. .|. |  |.. |  . .. .|. .
ilqlvkavservtantkastpilvhcsaGvGrtGvfislysalakvieesrvdifgfvkklrkdrpsmvetvdqyiliyealve

subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 72-338 4.9e-50 165.1 In-house 11-270 (287) alignment
Range on Protein: 72-338
Range on HMM: 11-270/287.0
IKAHSANNNAGFIETFTSIRD--GLGSAATASRSDANQHLNRYSNIVAYDATRVLVPknkeNFNCDYVNANWIPSE-GPRKYIAAQGPVPASLVSFWQMV
..   |..| || . || . .        | . .  |...||...|. .|  |||.     . . ||.|| .| .    ...|.|..|.   .. ||...
vakghakgnegfknqftvleqvtqredevthniasqnkdknRltqilvpdnyrvllk....gehpdyinavfidgykekkafiiaesPmfntarnfWkli

VEHDARLIVMLTNEIEGGKLKCHRYWPDDNmakashpqpvkKVKIGTYIVSFEGEESFPTYVHRKFKLYLES--GEARDVSQMAYTAWPDHG-VPATTKE
 ..    ||||..| |  . .|..|||...            | .| | ...  ||    |. ||...  ..  |. . | |  .|.|...| |.     
ddrnvtaivmlcqekendeevcyqyWpeek...........svvlGeyniellneevnagyierklevknknkagdkqqvkqyqitnWdstgkvtepqti

LLGFRLAVKDQLKRLNCTPLIHCSAGVGRTGTFIGLDRYIDRVLSKRDADVLDIVRDMRRARNFMIQFV--YLFL
|| .   .| | || | . ..|||..|||...|.  .  |...      ||..... .|  .  ..| |  | |.
llvieemyktqrkrgntsivvhCsdtvGrsamfcaaattinkckteGviDvfqvlksqriqkpgsvqtveqykfi

subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 106-333 6.2e-50 164.6 In-house 3-224 (237) alignment
Range on Protein: 106-333
Range on HMM: 3-224/237.0
NQHLNRYSNIVAYDATRVLVPKNKENfnCDYVNANWIPS--EGPRKYIAAQGPVPASLVSFWQMVVEHDARLIVMLTNEIEGGKLKCHRYWPDDNmakas
|.  |||.|||||| .||..  .  .  .||.||... .    |.||||||||. .|   ||||| .    .|||||  ||| .||||.|||. .     
nkiknrygnivaydhsrvvlkgagsg..sdyinatylkgfdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywpstd.....

hpQPVKkvkIGTYIVSFEGEESFPTYVHRKFKLYL--ESGEARDVSQMAYTAWPDHGVPATTKELLGFRLAVKDQLKR-LNCTP-LIHCSAGVGRTGTFI
  ||      | . ||.  .| |  |  | . |    .  | | . |  .|.|||.|||  |  || ||  . .. .   ...| .||||||||||| |.
..qpaa...ygvltvslkkkeefsdytvrslllskrltlkevrlihqyqftswpdrgvpqqtaallrfrkniinrsphvsesgpwiihcsagvgrtgifl

GLDRYIDRVLSKRDADVLDIVRDMRRARNFMIQF
 .|  . .   |.  |. . |  .   | ..|| 
vidamlrqakekkvvdiynyvysieedrpyiiqt

subfamily_PTPN14_pd Subfamily PTPN14 60-334 3.8e-49 162.3 In-house 3-282 (300) alignment
Range on Protein: 60-334
Range on HMM: 3-282/300.0
LAARHSQKLRAQIKAHSANNNAGFIETFTSIRDGLGSAATASRSDANQHLNRYSNIVAYDATRVLVPKNKENfNCDYVNANWIPS---EGPRKYIAAQGP
 |.|...  ||.|  .  ..   | |     .  . .  .... . |.. ||. ... |. .|| .  .||| . .|.||  |        |.||.||||
eatratkdkrakilekkleegkvfteyeripkkredallstaklpenaeknrfkdvlPyednrvelsptken.stgyinassikvsvggkersyivaqgP

VPASLVSFWQMVVEHDARLIVMLTNEIEGGKLKCHRYWPDDNMaKAshpqpvKKVKIGTYIVSFEGEESFPTYVHRKFKL-YLESGEARDVSQMAYTAWP
..  .  ||||| |.. .||||||.|.|.|| |...|.|...  |.      |.|. | . |. .  |. .... ...|| .| |.| |.|  . || ||
leltvqdfWqmvWeqgvqlivmlteeeedgkeksfkyfPkles.kk......ktvefgkfkvttkfsedsdsvittglklkhlpskeertvwhlqytDWp

DHGVPATTKELLGFRLAVKDQLKR---------LNCTPLIHCSAGVGRTGTFIGLDRYIDRVLSKRDADVLDIVRDMRRARNFMIQFV
|||||   |. | .   |.   ..          .   |.||||||||||  |  |  |  .   .. |.  ... .|. | ...| .
dhgvPeDvkgflsyLeevqsvrrktnseveskeskPPvlvhCsaGvGrtGvlilsdlliatlehneeidikkvlarLreqrmllvqtl

subfamily_PTPN23_pd Subfamily PTPN23 104-353 8.5e-49 160.9 In-house 41-286 (288) alignment
Range on Protein: 104-353
Range on HMM: 41-286/288.0
DANQHLNRYSNIVAYDATRVLVPKNKEnfncDYVNANWIPSEGP--RKYIAAQGPVPASLVSFWQMVVEHDARLIVMLTNEIEGGKLKCHRYWPDDNMAK
  . . ||. .|. || .|| . ..|.    ||.|| .. .  |   ..||.|.| . .|  ||.||.|  ...||||... | || |..|||| |. . 
klyseknrsrdilPyDhnRvklrgskD....DYinAsfvkdlspgcPdfiatqaPlqstlnDFWlmvyeqkssviVmllskeelgkpkvdrYwPedkget

ASHPQpvkkvkigtYIVSFEGEESFPTYVHRKFKLYL-ESGEARDVSQMAYTAWPDHGVPATTKELLGFRLAVKD---QLKRLNCTPLI-HCSAGVGRTG
 ....         . |. . ... .|.|.|..||   .. . ..|| . .|.||..||||. ..|| |  .|..   . .|   |||. ||||||||||
vkfgd.........lsvtlksvretethvervlkletldadavksvshlqltsWpelGvPasPetllqfldevesayeavqrksktPlvvhCsaGvgRtg

TFIGLDRYIDRVlSKRD--ADVLDIVRDMRRARNFMIQFVYLFLVCLDAM-DQLEKLLDK
.|  .   .  . .|..  .|....|. .|. | ||.| .  .  ...|.  . .. |||
vfalvyaavrel.ekgnglldiiqvvsrlreqRrfmvqekeqlkfsyeavleaarrvldk

subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 106-333 4.3e-48 158.8 In-house 28-253 (274) alignment
Range on Protein: 106-333
Range on HMM: 28-253/274.0
NQHLNRYSNIVAYDATRVLV-PKNKENFNCDYVNANWI--PSEGPRKYIAAQGPVPASLVSFWQMVVEHDARLIVMLTNEIEGGKLKCHRYWPDDNMAKA
.|. ||| .|.  . .|||. ... |. . .|.|||.|  ..|  . |.|.|||.|  .  ||.|. ......|||||.  |  . ||..|.||.. .. 
sqtknryktilPnensrvllesessededssyinanyikGydeeskayvatqGPlpntvadfWrmiyqeevqvivmltklkeaneqkCavyfPdaedyei

SHP-QPVKkvkigtyiVSFEGEESFPTYVHRKFKLYLESGeARDVSQMAYTAWPDHGVPATTKELLGFRLAVKDQLKRLNCT---PLIHCSAGVGRTGTF
|.  . |.        . .|.  .   |  ||. |   .   |.|  . ||.|||| .|  ...|| . | |... .. |      ..|||||.|||| |
serygdve........ikvekiverndysvrklvlkyler.ersvkhywytdWPdhksPddantlldlvleveesreeenaklapvvvhCsaGiGrtGcf

IGLDRYIDRVLSKRDADVLDIVRDMRRARNFMIQF
|. .  . ..  .   ||| || ..|  |  |.| 
iaisiavrqlreeivvdvlkivcnlrldrGGmvqt

subfamily_PTPN1_pd Subfamily PTPN1 97-332 1.3e-47 156.9 In-house 23-255 (290) alignment
Range on Protein: 97-332
Range on HMM: 23-255/290.0
AATASRSDANQHLNRYSNIVAYDATRVLVPKNkENfncDYVNANWIPSE-GPRKYIAAQGPVPASLVSFWQMVVEHDARLIVMLTNEIEGGKLKCHRYWP
 ..... ..|. |||| ..  || .|. . .. .|   ||.||. .  |   |.|| .|||.|     ||||| |.... .||| . .| ...||..|||
ptreaklpenrnlnryrdvspydhsriklera.dn...dyinaslveleeakrsyiltqGPlpntvdhfWqmvWeqkskavvmlnkvvekeqikcaqywP

DDNMakashpqpVKK--VKIGTYIVSFEGEESFPTYVHRKFKLY-LESGEARDVSQMAYTAWPDHGVPATTKELLGFRLAVKD--QLKRLNCTPLIHCSA
 ..         .|.  ..  .. | .  ||.  .|. |...|  |.. |.|..... ||.||| ||| .   .| |   |..   |..    ..|||||
qgee........ekellledtklkvkliseerksyytvrllelenlktqetreilhfhyttwpdfgvpespaaflkflfkvresGslssdvGpavihcsa

GVGRTGTFIGLDRYIDRVLSKRD---ADVLDIVRDMRRARNFMIQ
|.||.|||. .|  . ..  | |    |. . . ..|. |  .||
GiGrsGtfclvdtclvliekkddlssvdikkvllelrkyrlGliq

subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 101-344 8.2e-47 154.3 In-house 33-273 (287) alignment
Range on Protein: 101-344
Range on HMM: 33-273/287.0
SRSDANQHLNRYSNIVAYDATRVLVPKNKeNFNCDYVNANWIPS-EGPRKYIAAQGPVPASLVSFWQMVVEHDARLIVMLTNEIEGGKLKCHRYWPDDNm
.   |. . |||.... .| ||||. ..  ..  ||.|||...| .   ..||||||..|.. .||..|.|. .  ....| |.| ..|||..|||. . 
aeelaavkknryadvlPiddtrvllsaeg.elGsdyinanyvasytddeafiaaqgPiaatvrdfwravletrsasvitmtreveearlkcykywPere.

akashpQPvkkVKIGTY-IVSFEGEESFPTYVHRKFKLY-LESGEARDVSQMAYTAWPDHGVPATTKELLGFRLAVKDQL--KRLN---CTPLIHCSAGV
      .|   ...| | .| .. .   | |  | ..|  ||. ||| | |. . .|||.... |.  |. | | ||...  .|       ...|...|.
......vP...mrvGGysvvlldydikePeygvralrlidletrearvvkqldllswPdkvlaPtavglirfvldvkqhielardasevGPlvvhddvGi

GRTGTFIGLDRYIDRVLSKRDADVLDIVRDMRRARNFMIQFVYLFLVCLDAM
||.|... .   ..| ..    ||  .|  .|  |. ..| |  . .  .|.
GrsGillatlvlvsrledlGrvdvaavvirlreyraalvqavvqlrllyeal

subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 95-345 1e-46 154.8 In-house 50-288 (319) alignment
Range on Protein: 95-345
Range on HMM: 50-288/319.0
GSAATASRSDANQHLNRYSNIVAYDATRVLVPKNKENFNCDYVNANWIPS-EGPRKYIAAQGPVPASLVSFWQMVVEHDARLIVMLTneieggKLKCHRY
..  | .  | |.  ||. ||.|.| ..| . .       ||.|| ..     . |||||||| . .|  ||.|. |...  ||.||      | || .|
ladqtfanldqnkdknriinilafdknvvklerliGeefsdyinasfvtGyqrkdkyiaaqGPldntladfWrmiweyncstivllt......kdkcsqy

WPDDNMAKASHpqpvKKVKIGtyIVSfEGEEsfptYVHRKFKLYL--ESGEARDVSQMAYTAWPDHGVPATTKELLGFRLAVKDQLKRLN--CTPLIHCS
|| .   |  .     |||.    |  | .|    || |...|    .  . |.. |  .  |||.|||  . .|. .   |.   .. |     ..|||
wplkivikeer....fkvkvd..sve.etae....yvvrdielsedgkekdirkitqfhflGwpdvGvpdypsdlmrlvkkvrhltskenhranivvhcs

AGVGRTGTFIGLDRYIDRVLSKRDADVLDIVRDMRRARNFMIQFVYLFLVCLDAMD
|||||||..| ||  .||.  ..  || ..|||.|. || ..| .  .  .  |. 
aGvGrtGvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysall

subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 96-334 3.6e-46 152.7 In-house 41-270 (297) alignment
Range on Protein: 96-334
Range on HMM: 41-270/297.0
SAATASRSDANQHLNRYSNIVAYDATRVLVPKNKENFNCDYVNANWIPSEGPrKYIAAQGPVPASLVSFWQMVVEHDARLIVMLTNEIEGGKlKCHRYWP
 ..| ..   | . .||.||. ||  || .    .. . ||||| ....    ..|. | | .|..  ||.||.....  ||||... |. | || |||.
qpqtvaekkvnfeksRYkniLPydssRvkLaivnddpdsDyvnasfvkgnkh.rlittqmPmkatvadfWamvldeqvstivmlnddnerdk.kcaryWs

DDNMAKashpqpvkkvkIGTYIVSFEGEESFPTYVHRKFKLYLESG-EARDVSQMAYTAWPDHGVPA--TTKELLGFRLAVKDQLKRLNCTPL-IHCSAG
|. ...            |.  |  .  ..   ...|....  ..    | | |  .. |||. |.   ... || .   |... .  . .|| .||.||
dkgvtt...........fGdvsvvllsvsereGfikrelevtkgkakarrvvkqyqfveWPdkaverkdsassllklisevrkdfsqnaegPllvhclaG

VGRTGTFIGLDRYIDRVLSKRDADVLDIVRDMRRARNFMIQFV
||||| .. .|  . ..  . . |....|. .|. | ...|  
vGrtgvlltidsvvaeakrekevdifglvkklrqerpylvqtk

subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 96-345 4.9e-46 152.5 In-house 15-252 (284) alignment
Range on Protein: 96-345
Range on HMM: 15-252/284.0
SAATASRSDANQHLNRYSNIVAYDATRVLVPKNKENFNCDYVNANWIPS-EGPRKYIAAQGPVPASLVSFWQMVVEHDARLIVMLTneieggKLKCHRYW
.  | .  | |.  ||. .|.|.| ..| . .   .   ||.|| .|     . ||||.||| . .|  ||.|. |...  ||.||      | || .||
tdqtfanldqnkdknrighilafdknvvklerliGeefsdyinasfitGyqrkdkyiatqGPldntladfWrmiweyncstivllt......kdkcsqyw

PDDNMAKASHpqpvKKVKIGtyIVSfEGEEsfptYVHRKFKLYL--ESGEARDVSQMAYTAWPDHGVPATTKELLGFRLAVKDQLKRLN--CTPLIHCSA
| .   |  .     |||.    |. | ||    || |...|    .  . |.. |. .  |||.|||  . .|. .   |.   .. |   . ..||||
plkivikeer....fkvkvd..sve.esee....yvvrdielsedgkekdirkirqfhflgwpdvgvpdypsdlmrlvkkvrhltskenhranivvhcsa

GVGRTGTFIGLDRYIDRVLSKRDADVLDIVRDMRRARNFMIQFVYLFLVCLDAMD
||||||..| ||  .||.  ..  || ..|||.|. || ..| .  .  .  |. 
gvgrtgvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysall

subfamily_PTPRN_pd Subfamily PTPRN 97-343 1.8e-45 150.0 In-house 47-287 (297) alignment
Range on Protein: 97-343
Range on HMM: 47-287/297.0
AATASRSDANQHLNRYSNIVAYDATRVLVPKNKENFNCDYVNANWIPSEGPRK--YIAAQGPVPASLVSFWQMVVEHDARLIVMLTNEIEGGKLKCHRYW
........ | . ||......|| .|| . .. .. . ||.||  |  . ||.  |||.|||..... .||||| |. . .||.||.  | |  .|.|||
tkevakaeknvkknrskavlpydhsrvklkeeasaeksdyinasaildhdprapayiatqgplastvadfwqmvweqGvvvivnltrleeegvkqckryw

PDDNmAKASHPQPVKKVKigTYIVSfegEesfpTYVHRKFKL-YLESGEARDVSQMAYTAWPDHGVPATTKELLGFRLAVKDQLKRLNCTPLIHCSAGVG
||.  ..  |   |. |    .| .   .     |. | | |  |.. |.| |.|. . .||..||||..| || ||  |    .   |. ..|||.|.|
pdeG.sevyhiyevhlvs..ehiwc...d....dylvrsfylknlqtsetrtvtqfhflswpeegvPasaksllefrrkvnksyrGrscpivvhcsdGaG

RTGTFIGLDRYIDRVLS-KRDADVLDIVRDMRRARNFMIQFVYLFLVCLDA
|||..| .|  ..|.|   .. |.   .  .|  |. ...    | ..| |
rtGvyilidlvlnrllkGvkeidiaatlehlrdqrpglvktkdqfefalta

subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 102-339 4.2e-43 142.2 In-house 3-235 (239) alignment
Range on Protein: 102-339
Range on HMM: 3-235/239.0
RSDANQHLNRYSNIVAYDATRVLVPKNKENFNCDYVNANWIPS--EGPRKYIAAQGPVPASLVSFWQMVVEHDARLIVMLTNEIEGGKLKCHRYWPDDNm
.   |.  |||.|||.|| .||.. |  ..   ||.||...      |. |||.|| | .|   ||.|. .    .|||||  ||| | |||.||||   
kkrvnkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdst.

akaShpqpvkkvKIGTYIVSFEGEESFPTYVHRKFKLY-LESGEARDVSQMAYTAWPDHGVPATTKELLGFRLAV-KDQLKRlNCTPLIHCSAGVGRTGT
   |        |     |..   | |  |. | | .  .   | | | |  .| |||.|||  .  .||.|  . || |       .|||||||||||.
...s........kycnlrvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrkitkdslpg.arpwvihcsagvgrtga

FIGLDRYIDRVLSKRDADVLDIVRDMRRARNFMIQ----FVYLFLV
|. .|  . .   ..  |... |. .|  | .|.|    .|...| 
flvidamlrqakkqktvdifnyvkairedrphmvqtseqyvfihla

subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 101-334 5e-43 142.0 In-house 3-227 (239) alignment
Range on Protein: 101-334
Range on HMM: 3-227/239.0
SRSDANQHLNRYSNIVAYDATRVLVPKNKENFNCDYVNANWIPS--EGPRKYIAAQGPVPASLVSFWQMVVEHDARLIVMLTNEIEGGKLKCHRYWPDDN
..   |.  |||.|||.|| .||.. |  ..   ||.||...      |. |||.|| | .|   ||.|. .    .|||||  ||| | |||.||||  
akkrvnkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdst

makaShpqpvkkvKIGTYIVSFEGEESFPTYVHRKFKLY-LESGEARDVSQMAYTAWPDHGVPATTKELLGFRLAV-KDQLKRlNCTPLIHCSAGVGRTG
    |        |     |..   | |  |. | | .  .   | | | |  .| |||.|||  .  .||.|  . || |       .|||||||||||
....s........kycnlrvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrkitkdslpg.arpwvihcsagvgrtg

TFIGLDRYIDRVLSKRDADVLDIVRDMRRARNFMIQFV
.|. .|  . .   ..  |... |. .|  | .|.|  
aflvidamlrqakkqktvdifnyvkairedrphmvqts

subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 77-336 4.2e-41 135.6 In-house 14-224 (392) alignment
Range on Protein: 77-336
Range on HMM: 14-224/392.0
AN--NNAGFIETFTSIRDGLGSAATASRSDANQHLNRYSNIVAYDATRVLVPKNKENFNCDYVNANWIPSEGP-RKYIAAQGPVPASLVSFWQMVVEHDA
 .   .| |.| |  . .   .  |... . |.. ||| ||. ||..|| .    .  . ||.|| .|||    . |||.||| .|||  ||.|| ....
eknrhsalffeefhdlpgpdiypqtvaqkeinlkknryknilpydsarvkleviddipdsdylnasyipsfdnekayiasqgpnaaslddfwrmvfqenv

RLIVMLTNEIEGGklkchrywpddnmakashpqpvkkvkigtyivsfegeesfptyvhrkfklylESGEARDVSQMAYTAWPDHGVPATTKELLGFRLAV
  |.|.|.  ||                                                        .|| |.|  .| |||..||  |  || |   |
ttiamvtklkegd....................................................kgddartvaqfhftewPdkdvpkhtssllkfikev

KDQLKRLNCTPLIHCSAGVGRTGTFIGLDRYIDRVLSKRDADVLDIVRDMRRARNFMIQFVYL
| .  .     .|||||||||||  | .|  . .    |  ||...| ..|| | .|.|    
kadfGqythpliihcsagvgrtgvvisidsvvahakktrmvdvfnfvtnirrkrpymvqtkeq

0041856 (Phosphotyrosine protein) phosphatases II 106-340 5e-40 132.4 In-house 1-163 (182) alignment
Range on Protein: 106-340
Range on HMM: 1-163/182.0
NQHLNRYSNIVAYDATRvlvpknkenfNCDYVNANWIPSEGPR-KYIAAQGPVPASLVSFWQMVVEHDARLIVMLTneieggklkCHRYWPddnmakash
|...||||.|. || .|          ..||.|||.. .  |  ..||.||| . .. .|..|. |.. ..||.||         ...|||         
nldknrysdilpydhsr..........dldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt.........eelywp.........

pqpvkkvkigtyivsfegeesfptyvhrkfklyleSGEARDVSQMAYTAWPDHGVPAtTKELLGFRLAVKDqlkrLNCTPLIHCSAGVGRTGTFIGLDRY
                                   . . | . |  |. |||||||  . ||| |  .|..     ... |.|||||||||||.....  
...................................ellerlgiqylylpwpDhgvpd.ldelldfieevle....eggpvlVHCsaGvgRtgtlvaaylm

IDRvlskrDADVLDIVRDMRRARNFMIQFVYLFLVC
. .     . .. ..|. .|..|. |..    . ..
kkl.....gvsleeavklvrsrRpgmvitpnqyffl

subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 98-365 8.3e-40 131.7 In-house 33-297 (307) alignment
Range on Protein: 98-365
Range on HMM: 33-297/307.0
ATASRSDANQHLNRYSNIVAYDATRVLVpkNKENFNCDYVNANWIP-SEGPRKYIAAQGPVPASLVSFWQMVVEHDARLIVMLTNEIEGGKLKCHRYWPD
 |.   .||.. |||... . | .|..|  . .    ||. ||..  .  |.|.|.||||  ..  ||| |.....   ..|| . || .|.||..||| 
vtveafsantdknryqdvkcqdkgrivv..kfdglasdyihanylgiaikpkkficaqgplentqysfwamaiqekvesvimlckvielakikceqywpl

DNMAKASHPQPVKKVKIGTYIVS-FEGEESFPTYVhrKFKLYLeSGEARDVSQMAYTAWPDHGVPATTKELLGFRLAVKDQLKRLnctpLIHCSAGVGRT
..  |  . .  . . .    .  .  .| .      ..|.   ....| .... .. |||.||| .    . .  ||. .   .    ..||||||||.
eegqklvfgeapntisvanlgakklapdedlinvt..tlkvdw.aqksrtiqhlqwenwpdrgvpqinltainlleavrydtnpv....vvhcsaGvGrs

GTFIGLDRYIDRVLSKRD-ADVLDIVRDMRRARNFMIQ----FVYLFLVCLDAMdqLEKLLDKYLAL-ATKSEEEQ
|| ...    |....  .  |. ..|...|  |.. ||    ..||  | |. .  ||.  . |  |  ||  ||.
GtivaislvqdkmiaGinckdmkklveelrsqrhyaiqteaqylylhrvlleyf..lelyketyeellltknyeek

subfamily_ptpA1_pd Subfamily ptpA1 85-318 3.5e-39 129.7 In-house 25-269 (418) alignment
Range on Protein: 85-318
Range on HMM: 25-269/418.0
ETFTSIRDGLGSAATAS-RSDANQHLNRYSNIVAYDATRVLVPKNKENFNCDYVNANWIPSEGPRKYIAAQGPVPASLVSFWQMVVEHDARLIVMLTNEI
| |  . . .| . |.      |   |||.||.  . ||| . | ...   ||.|||.|    |...|..|||.| ..  ||.|| |  .|.||||. | 
eefrlleesvgpsetsegdkkhntsknrytnilpvnhtrvqlkkiqdkegsdyinanyidgaypkqfictqgplpntiadfwrmvwenrcriivmlsres

EGGKLKCHRYWPDDNMAKASHPQPVKKVKIGTYIVSFEGEESFP--TYVHRKFKLYLEsGEARDVSQMAYTAWPDHGVPATTKELLGFRLAVKD---QLK
|  ..|| ||||..   .        .  .||| | .      |    . |. .| .| ||.||..|  |  |||| .|  |. .  .  .. .   |. 
encrikcdrywpeqiggeqfsiygngnevfgtysvelveviqdpereiitrnirltfe.getrditqyqyegwpdhnipdhtqpfrqllhsitnrqnqii

---RLNCTPLIHCSAGVGRTGTFIG---LDRYIDRVLSKRDADVLD
     |   ..||||||||||||     . . .|. . . ||  .|
pssdrnvpiivhcsagvgrtgtfctavimmkkldhyfkqldatpid

subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 76-389 1.2e-38 127.7 In-house 15-316 (439) alignment
Range on Protein: 76-389
Range on HMM: 15-316/439.0
SANNNAGFIETFTSIRDGLGS---AATASRSDANQHLNRYSNIVAYDATRVLVPKNKENFNCDYVNANWIPS-EGPRKYIAAQGPVPASLVSFWQMVVEH
  |..  | | | .|          |.    . .|  ||| ...|.| ||| . .        |.|||.|     .. |||.|||   .  .||..|.|.
dknkqeifkeifekinstspdyaciaslaaqeydqtknrykdvgafdhtrvtlqeipgvphshyinanyikGyyddklyiatqgpkkettddfwrlviek

DARLIVMLTNEIEGGKlkchrYWPDDNmakashpqpvkKVKIGTYIVSFEGEESFPTYVHRKFKLYLESG---EARDVSQMAYTAWPDHGVPATTKELLG
 .  |||||| .|  |     ||| |.           .|  |  .|  . .  .| || | ||.. |       | | |. |.||||. ||| .  .| 
ktvtivmltnlvesyk.....ywpsda...........evcygdiavrvdrnielpnyvirgfkvfnerdttekertvlqfhyiawpdknvpaqashvld

FRLAVKDQLKRLNCTPL-IHCSAGVGRTGTFIGLDRYIDRVLSKRDADVLDIVRDMRRARNFMIQFVYLFLVCLDAMdqLEKLldKYLALATKSEEEQQE
|  |..    . .. |. .||||||||||| | ||  .... ..   |.  ||. .|. |. |.| .  ...  .|.  || .  .| ..|.  .| ..|
flrainsandkeeygpvvvhcsagvGrtGtiialdialeqlklenkvdikgivkvlrkqrkqmvqalcqyvfiynav..ledi..vyGdiavtidefkke

EELAALTQELVATEDEAVATIK
 .   .|...   ..|  ...|
fnagfstrdisifneedssllk

0051429 (Phosphotyrosine protein) phosphatases II 135-347 2.2e-38 127.8 In-house 5-224 (272) alignment
Range on Protein: 135-347
Range on HMM: 5-224/272.0
DYVNANWIPSEGP----RKYIAAQGPVPASLVSFWQMvVEHDARLIVMLTNEIEGGKLKCHRYWPDDNMAKASHPQP-VKKVKIGTYIVSFEGEESFPTY
.|.||....  |     .......|| |..  .||..  |.. . ||.|..| | |.|||.||||. .    . .   .  . .| . | .  || .. |
gyiNardvggygrvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseellldy

VHRKFKLYLE--SGEARDVSQMAYTAWPDHGVPATTkeLLGFRLAVKDqlkrlNCTPLIHCSAGVGRTGTFIGLDRYIDRVLSKRDAD--------VLDI
..|.. |.|.   |||| | .. ||.|||||||  .  || .  .. |     .   |.|||||..||||.. |.. . .|     .|        ....
ilrellltlllsagearevmhlhytdwpdhgvpqea..llellellld.....ggpvlvHCsaGkdRTGtvvallllllgvsletivddYlltnlyleea

VRDMRRARNFMIQFVYLFLVCLDAMDQL
|. .|..|  ..|    .| ...|. .|
veelraqrpgavqteeqylflyeallel

subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 74-347 2.9e-38 126.3 In-house 8-292 (301) alignment
Range on Protein: 74-347
Range on HMM: 8-292/301.0
AHSANNNAGFIETFTSIRDGLGSAATASRSDANQHLNRYSNIVAYDATRVLVPKNKE--NFNCDYVNANWIPSE-GPRKYIAAQGPVPASLVSFWQMVVE
 . |... .| | ......|    .| . |..|..|||. ||. ||  |... ....    . .|.||..| .    .|.||||||.   || ||.....
hvaakhsnkfeeqykelkegedksctvglseenkalnrfknitvyddnriilkpkpnldlcqreyinasyidgysekkkfiaaqgpmkktlvdfWrliwq

HDARLIVMLTNEIEGGKLKCHRYWPDDNMAKASHpQPVKKVK-----IGTYIVS-F--E-GEESFPTYVHRKFKLYLESgEARDVSQMAYTAWPDHGV-P
.    |||.||. || | ||..|||. .. . .   |..        .  ...  .     . |  .|..||||   .  ...|| |.  | ||..|| .
ekpvsivmvtnlkegtkskceqywpnseaeseef.gpftvtlvneqvyPdfvirqlnvkiqdgsnngyierkfkvksdk.sswdvlqlqvtdWpqdGvvr

ATTKELLGFRLAVKDQLKRLNCTPLIHCSAGVGRTGTFIGLDRYIDRVLSKRDADVLDIVRDMRRARNFMIQFVYLFLVCLDAMDQL
     |      .. | |      ..|||..|.|.|... ..  .. . .    || .... .|| .  ...    .    |..|. 
eprtvLqviddvihrqqkigggpvvVHCSdtVsrsGvYcsvsiglEQckaegVVdvfqvtkavrrskpgaVtTLeqytsiydvidmy

subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 96-344 4.5e-38 125.8 In-house 23-291 (297) alignment
Range on Protein: 96-344
Range on HMM: 23-291/297.0
SAATASRSDANQHLNRYSNIVAYDATRVLVPKNKenFNCDYVNANWI--PS-EGPRKYIAAQGPVPASLVSFWQMVVEHDARLIVMLTNEIEGGKLKCHR
 . .... ..  . ||| .|.|.| ||| . .     . ||.||...  |  | . ||| ||||. |..  ||..|.|.| | |||...  |.|. ||  
esfssakrnsslrknryrdilatddtrvkllrvi..terdyinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmvaklqedGrdkcap

YWPDDNMAKASHPQPVkkvkiGTYiVSFEGEEsFPTYVHRKFKLYLEsGEARDVSQMAYTAWPDHGVPATTKELLGF-------------RLAVKD----
|||. .  .   .. |       . .|   .| | . .  ...|.    | | |  . . .|||||||.  ..|  |              ||. .    
ywpsvvqerlkagdvv.....vef.lsstsde.fdrviltelqliyr.sesrvvrhvqflswpdhGvpsdledlvrfqaqvcscciavpmmlalvemfta

----QLKRLN------CTPLIHCSAGVGRTGTFIGLDRYIDRVLSKRDADVLDIVRDMRRARNFMIQFVYLFLVCLDAM
    ||. |.         |.||||||||.|  .  |  ....  ||  ||  |.. .|  |  ..| .  | .. ||.
mvflqleslraemprnayllvhcsaGvGrsGvvvlsdvilaklrkkripdvaailsilreqrarlvqtleqfellydav

subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 77-334 1.1e-36 121.2 In-house 5-252 (283) alignment
Range on Protein: 77-334
Range on HMM: 5-252/283.0
ANNNAGFIETFTSIRDGLgSAATASRSDANQHLNRYSNIVAYDATRVLVPKNKEnfncDYVNANWIP----SEGPRKYIAAQGPVPASLVSFWQMVVEHD
.|||  | |..  .       |. . .| |.. ||. .||..|  || .  . .    ||.|| .||     .  .|||.||.|.    | ||.|| ...
vnnnklfrevlkrlsvpd.ldadiasadenkrknrnqeivpadqwrvelksesr....dyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfdek

ARLIVMLTNEIEGGKLKCHRYWPDDNmakaShpqpvkkVKIGTYIVSFEGEESFPTYVHRKFKLYLESGEAR--DVSQMAYTAWPDHGVPATTKELLGFR
.  |||||.  |. . || .||| .     |       .. | . |. . | .  ... ... |  .|       ..   .  | . |  |    |. | 
itaivmltklqedlrikCsqyWPkrG....s.......edyGeftvtlrkettsnsfiikelllrvnssakstlllahyqvidWleygeqaiinslvkfn

LAVKDQLKRLNCTPLIHCSAGVGRTGTFIGLDRYIDRVLSKRDADVLDIVRDMRRARNFMIQFV
. .  | .  .   ..|||.|.|||..||..   .. .|..   ||  .|. ||  |  ..|  
kvislqteskkgPivvhCstgiGrtavfiaasasvkdaltesvvdvfavvkimreqrmmavqtl

0036282 (Phosphotyrosine protein) phosphatases II 135-333 2.2e-35 117.3 In-house 3-155 (174) alignment
Range on Protein: 135-333
Range on HMM: 3-155/174.0
DYVNANW-----IPSegprKYIAAQGPVPaslvsFWQMVVEHDARLIVMLTNEIEGGKLKCHRYWPDdnmakashpqpvkkvkigtyivsfegeesfpty
|| ||..     |..    ..|| ||| .     ||.|. |.. . .|||..|.| |. ||..|||.                                 
dyinaspldlsyitp....rliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe.................................

vhrkfklyLESGEARDVSQMAYTAWPDHGVPATTKeLLGFRLAVKDQLKR-LNCTPLIHCSAGVGRTGTFIGLDRYIDRVLsKRDADVLDIVRDMRRARN
        | . . | . |  |. ||||||| ... || |  .|.. |..  ... |.|||||||||||...... . . |  .  |.||.|| .|. | 
........lredlerlgiqylylpwpDhgvpdlsi.llefvkfveealsedpggpvlVHCsaGvgRtGtlvaaylmlrgll.eslvdaldlvrelRlqrp

FMIQF
 |.| 
gmvqt

subfamily_CG7180_pd Subfamily CG7180 96-344 9.5e-35 114.7 In-house 33-286 (296) alignment
Range on Protein: 96-344
Range on HMM: 33-286/296.0
SAATASRSDaNQHLNRYSNIVAYDATRVLVPKNKENFNCDYVNANWIPS-EGPRKYIAAQGPVPASLVSFWQMVVEHDARLIVMLTNEIEGGKlKCHRYW
  |.. |.. |.  ||. ..| || .||...| . . . ||.|| .. |   ...||  ..|.  .. .||..| ....  .|.||.. .  | ... ||
dCagglrke.nreknrdvkvvPyDynRvvLekldGeeksdYinavyvdsflkkkeyivteapkketvdefWrlvydeeisavvvLtktfdfak.mypsyw

PDDNmakashpqpvkKVKIGTYIVSFEGEESFPTYVHRKFKLYLE-----------SGEARDVSQMAYTAWPD-HGVPATTKELLGFRLAVKDQLKRL--
| .            | . |  .|    |....  . |.|||. .           . | | | .. .| |.  . ||  |. |. .|  |.   ..   
pnks...........keqygeifveiveekqyanlkirtfkltkkivalteqekqvkaetRivklfqlteWeledkvPlstnalielrrrvrlwrekvde

--NCTP-LIHCSAGVGRTGTFIGLDRYIDRVLSKRDADVLDIVRDMRRARNFMIQFVYLFLVCLDAM
  .  | ....| |..|.| ....|  .. |  .   || . |. .|| |. ... |  .  . | .
dpeegPvvvvssdGasRsGvylaidanlelvekeeevdvFeavktlrrsRpqLvenveeYkyiYdvl

subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 102-360 2.8e-34 113.1 In-house 51-303 (305) alignment
Range on Protein: 102-360
Range on HMM: 51-303/305.0
RSDANQHLNRYSNIVAYDATRVLVPKNKenfNCDYVNANWI--PSEGPRKYIAAQGPVPASLVSFWQMVVEHDARLIVMLTNEIEGGKLKCHRYWPDDNM
 .| ..  |||... . | . |.. |      .||. ||..  |    ...|.||||.  ..  || ||...    |||| . .| ||||| .|||  . 
sadiaitknryqdvpcqdqsavkldkps...psdyihanyvgcpmipekrficaqgpldqtidefwwmviqnkveqivmlcktvelgklkcaqywpaaqg

AKashpqpvKKVKIGTYIVSFEG---EESFPTYVHRKFKLYLESGEARDVSQMAYTAWPDHGVPATTKELLGFRLAVKDQlkrlNCTPLIHCSAGVGRTG
 |       ...| |  .    |    |  .      ..|    ..   | .. .| ||| |||      | .  |..      .   ..|||||.||||
ek.......lelksgivvenvsgskpmerdaeiqitllnltysgdqkmsvrhlqwtewpdrgvppckltslellsairgs....kvpivvhcsagigrtg

TFIGLDRYIDRVLSKRDA-DVLDIVRDMRRARNFMIQF--VYLFLVCLDAMDQLEKLLDKYLALATK
| . ..  ....  ....  . ..|. .|  | | ||    |||.  .     |||  .|| || | 
tivaieyilekiaenkpcppmpelvkalrdqrafsiqndvqylfihrvmlnyflekykekyaallta

subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 104-343 9e-34 111.4 In-house 52-278 (290) alignment
Range on Protein: 104-343
Range on HMM: 52-278/290.0
DANQ--HLNRYSNIVAYDATRVLVpknKENFNCDYVNANWIPSEGPrKYIAAQGPVPASLVSFWQMVVEHDARLIVMLTNEIEGGKLKCHRYWPDDNMak
|.|   . ||| ..|  | |||..   |. .. ||| ||..    .  .| .||.. .. . .|.||.....  |||| . || || ||..|.|. .   
dkntefkknrykdvvcndktrvil...kdGydGdyvhanyvkGlka.mfiltqGalkdtvidiwrmvlqekvaaivmlceliedGkakceqyypekeG..

ashpqpvKKVKIGTYIVSFEGEESFPTYVHRKF--KLYLESGEARDVSQMAYTAWPDHGVPATTKELLGFRlavkDQLKRLNCTPLIHCSAGVGRTGTFI
       . . .| . |    |..  . . .|       .||    .  .   .|||. |. .|  ||         |....    .|||||.||||||.
.......evltfGeitvlcseeddkdaniikktlsvrdkdsGkehklkhlkikswpdksvalstlallrtl....rilrkasGpvvvhcsaGiGrtGtfv

GLDRYIDRVLSKRDADVLDIVRDMRRARNFMIQFVYLFLVCLDA
 ..  .. .|  .. |.||.|| .|..|   .|    .|. ...
aievglqilldGkeldlldlvralrnsrlnsvqvdiqylalvei

0046846 (Phosphotyrosine protein) phosphatases II 129-338 1.6e-33 111.3 In-house 7-163 (176) alignment
Range on Protein: 129-338
Range on HMM: 7-163/176.0
KENFNCDYVNANWIPSEgprKYIAAQGPVPASLVSFWQMVVEHDARLIVMLTNEIEGGKLKCHRYWPDdnMAKASHpqpvkkvkigtyivsfegeesfpt
 .....||.|||.| .    ..|| |||.| .| .|..|. |.. ...|.||.|.| |.|||..|||.  . |...                        
gldldldyinanlilgs...rpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpe..leklgi........................

yvhrkfklylesgeardvsQMAYTAWPDHGVPATtKELLGFRLAVKDQLKRlNCTPLIHCSAGVGRTGTFIGLDryidRVLSKRDADVLDIVRDMRRARN
                   |  .. |||||||   . || .  .....||. . . |.|||||.|||||.. ..     . .... .|..... .|. | 
...................qylhlpwpDhgvpdl.elllellefirealke.ggpvlVHCsaGigRtgtlvaay....llelekglsveealalvreqRp

-FMIQFVYLFL
 ...|      
lgavqtpeQyr

0049772 (Phosphotyrosine protein) phosphatases II 101-353 2e-33 111.8 In-house 41-285 (314) alignment
Range on Protein: 101-353
Range on HMM: 41-285/314.0
SRSDANQHLNRYSNIVAYDaTRVLVpKNKENFNCDYVNANWIPSEgpRKYIAAQGPVPASLVSF----------WQMVV--EHDARLIVM----------
..  .|.. ||| .|. .| .|| . .. .....|| ||... .   .|.||.||| .  .|.|          |.||.  ... | |||          
adlflnrdknryldilpad.nrvil.pglpvsgsdyinasyvdgf..lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivmsrdevladel

-----------LTNEIEGGklkchrywpddnmakashpqpvkkvkI----------GtyivsfegeesfptyvhrkFKLYLESGEARDVSQMAYTAWPDH
           |..  ..|                                                           ||  .   | . .  .. .||.
srLdaAlgKtpllildgng..........................neptaadlellk...................eelydpelferlgikylripvpDg

GVPaTTKELLGFRLAVKDQlkRLNCTPLIHCSAGVGRTGTFIGldryIDRVLSKRDADVLDIVRDMRRARN-----FMIQFVYLFLVCLDAMDQLEKLLD
..| ... .. |  ....   . .   |.||.||.||||||.     .. ...... .. ....|.|..|       .|..  ... .|.|. .. | | 
sap.lledfdeflefieea..dkggpvlvHCkaGkgRtgtfvv....aaylmkllgvsleealedvrlkRpinpnpgfieqleqyefilealleylkflk

K
|
k

0043147 (Phosphotyrosine protein) phosphatases II 133-334 4.3e-32 106.6 In-house 4-147 (172) alignment
Range on Protein: 133-334
Range on HMM: 4-147/172.0
NCDYVNANWIPSE-GPRKYIAAQGPVPASLVSFWQMVVEHDARLIVMLTNEieggklkchrywpddnmakashpqpvkkvkigtyivsfegeesfptyvh
..||.||....    |...|| ||| .  | .||.|. |.. ..||.||..                                                 
gsdyinasyldlyyipdrfiatqgplrntladfwrmlkelgithivnltel.................................................

rkfkLYLESGEARDVSQMAYTAWPDHGVPaTTKELLGFRLAVKD-QLKRLNCTPLIHCSAGVGRTGTFIGLDRYIdrvlskRDADVLDIVRDMRRARNFM
    ||. ... | . |  |. ||||||| ... || |   ... .... ... |.|||||||||||.. ..  .      .. .....|. .|..|. .
....lydpellerlgiqylylpwpDhgvp.llellleflefidellalspggpvlVHCsaGvgRtgtlvaaylml......lglsleeavalvrekRpga

IQFV
.|  
vqnp

subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 96-341 8.5e-32 105.2 In-house 25-267 (285) alignment
Range on Protein: 96-341
Range on HMM: 25-267/285.0
SAATASRSDANQHLNRYSNIVAYDATRVLVpknkENFNCDYVNANWI--PSEGPRKYIAAQGPVPASLVSFWQMVVEHDARLIVMLTNEIEGGKLKCHRY
  .| .  .||  ||||... . . |||..    .|.. ||. |.|.  | .    ||..|||.| .|  ||.|. .     ..||   .|||  ||  |
pnctytayeanpdlnryadvrcieetrvvl....knhdrdyihaswmrmpgkdqstyittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekcaly

WPDDnMAkashpqpvKKVKIGTYIVSFE--GEESFPTYVHRKFKLYL-E--SGEARDVSQMAYTAWPDHGVPATTKELLGFRLAVKDQLKRlNCTPLIHC
.|.  .         . ||.| | ...    ||.    .   . .   |  | |   . ..    |||.  |  .. .. .   ||    . .    .||
ypek.lg........evvkfgkyeitlteckeeaiagtilnaltvintedasseplymnhvqvpwwpdqlapedarpmielykwvkkvnpk.ekpicvhc

SAGVGRTGTFIGLDRYIDRVLSKRDADVLDIVRDMRRARNFM----IQFVYLFLVCL
||||||| ||.|.|    |.. . . ..|||||.||  |       .||..|..| .
sagvgrtatfvgidyatirimenpniemldivremramrfqavqshmqflflyvvlm

0049260 (Phosphotyrosine protein) phosphatases II 147-333 1.4e-31 104.6 In-house 8-135 (152) alignment
Range on Protein: 147-333
Range on HMM: 8-135/152.0
PRKYIAAQGPVPASLVSFWQMVVEHDARLIVMLTNEIEGGKLKCHRYWpddnmakashpqpvkkvkigtyivsfegeesfptyvhrkfklylesgeardv
|...||.||| | .| .||.|. |.... |||||.. | |||||..|.                                                    
pfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi....................................................

sQMAYTAWPDHGVPATTKELLGFRLAVKDQLKRLNCTPLIHCSAGVGRTGTFIGLDRYIdrvlskRDADVLDIVRDMRRARNFMIQF
 |  .. |||||||  .  || . |...  ... ... |.|||||||||||.. ..  .      .. .....|. .|..|. ... 
.qylhlpwpDhgvpdlsqlllflllfieklaldkggpvlVHCsaGvgRtgtlvaaylml......lgvsleeavalvrekRpgavpn

0044763 (Phosphotyrosine protein) phosphatases II 118-339 3.8e-30 100.2 In-house 2-162 (178) alignment
Range on Protein: 118-339
Range on HMM: 2-162/178.0
YDATRVLVPKNKENFNCDYVNANWIPsegPRKYIAAQGPvpaslVSFWQMVVEHDARLIVMLTNEIEGGKLKCHRYWPDDNMakashpqpvkkvkigtyi
.| ||||...    . .|| ||..|    |. |.....|     ....... |.. ..||.||.|.|.|.|||..|||...                   
ldrtrvllsnleglersdyinaseil...pglylgslpp.....addlellkelgithivnlteelelgflkcdpywpeeag..................

vsfegeesfptyvhrkfklylesgeardvSQMAYTAWPDHGVPATTKELLGFRLAVKDQLKRLNCTPLIHCSAGVGRTGTFIGLDRYIDRvlskrDADVL
                              |. .. .||||||  .. .| |  .... |.. ... |.||||||||.||.. ..  . .     . .. 
.............................iqylhipipDhgvpdllehflefvefieealdekggpvlVHCsaGvgRsgtlvaaylmkkl.....glsle

DIVRDMRRARNfMIQFVYLFLV
.... .|..|. ...       
eaielvrerRp.ivpnpgqlrq

0051082 (Phosphotyrosine protein) phosphatases II 135-343 1.6e-29 97.8 In-house 4-148 (151) alignment
Range on Protein: 135-343
Range on HMM: 4-148/151.0
DYVNANWIPSEgprkYIAAQGPVPaslvSFWQMVVEHDARLIVMLTNEIEGGklKCHRYWPDDNmakashpqpvkkvkigtyivsfegeesfptyvhrkf
|| |.... .     ... .|| .     |.... |.. . ||.|..| | |  .|..|.|. .                                    
dyinfsyvtgg....lyrsggpla....dflellkelgiktivnlrseeerg..ycpeylpelg....................................

klylesgeaRDVSQMAYTAWPDHGVPATTKELLGFRLAVKDqlkrL-NCTPLIHCSAGVGRTGTFIGLDRYIDRvlskrdADVLDIVRDMRRARNFMIQF
         ..| .. .. |||.|.| .....| |  .. |      |   |.|||||.|||||...|.. . .       .. ......|. |  ..| 
.........ievlhipildwpdpglplsfdavleflellld....kkngpvlvHCsaGkgRTGtlvalylmllg......vsleealeeyrlkrpgvvqp

VYLFLVCLDA
   ||..| |
nqqflfqlfa

subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 106-349 6.1e-29 95.7 In-house 50-283 (301) alignment
Range on Protein: 106-349
Range on HMM: 50-283/301.0
NQHLNRYSNIVAYDATRVLVPKNKENFNcdyVNANWIPSEG-PRKYIAAQGPVPASLVSFWQMVVEHDARLIVMLTNEIEGGKLKCHRYWPDDNMakash
... .|| ..     | | | .. .      . |||||..| |...||.|||....   || |.| .|   ||||....|  . ||. | | .       
pkdkhryptvPckPstavevivdGkrvP...ihanwiptsGhphrfiatqgPlkntsedfwamlvqydvekivmlgqkvekleekceeylpvkis.....

pqpvKKVKIGTYIVSFEGEESFP--TYVHRKFKLYLESGE--ARDVSQMAYTAWPDHGVPATTKELLGFRLAVKDQLKRLnctpLIHCSAGVGRTGTFIG
    .|..|| . .  . .|.      ..|....   .|.  .| |    |. |.|.||| .  ||  .   ||.  | .    ..|||||.||. .|||
....ekldigrfkikiknkelilnkkiskrtlevedstgkfatrtvthyqysewtdrgvPkshaelfdlmelvkksekPi....vvhcsaGiGrsvafig

LDRYIDRVLSKRDADVLDIVRDMRRARNFMIQFV-YLFLVCLDAMDQLEK
 .    .|....  .. . ....|  |   .| .  |. . | .. .| |
teylareveadptieltealkhlrehrwngvqtnsqlywmtlGtvyrlik

subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 103-338 6.1e-28 92.4 In-house 45-279 (305) alignment
Range on Protein: 103-338
Range on HMM: 45-279/305.0
SDANQHLNRYSNIVAYDATRVLVpknKENFNCDYVNANWIPS-EGPRKYIAAQGPVPASLVSFWQMVVEHDARLIVMLTNEIEGGKLKCHRYWPDDNMAK
   ... ||| ..   |  || .   .  .  .|. ||.. .   |...| .| |.  .   || | ...    | || | .| |  ||. |.. ..  .
eaqeagknrykdvgcldnnrvkl...egpwpheyihanyvstptnpkrfictqaplektcadfwymclqdkveaifmlcnllekgakkcleyfaskdkdv

ASHPQPVKKVKI---GTYIVSFEGEESfPTYVHRKFKLYLESGEARDVSQMAYTAWPDHGVPATTKELLGFrlAVKDqlKRLNCTPLIHCSAGVGRTGTF
 .  .  .|. .    .  ..|. . .  .  . .. .    ..|| |..  .  ||| ||||.   .| .    |   . .     .|||||.||||. 
lefeekgqkisvkfessvtlkfrkdak.akvtetvlviegpgekarkvthyhwidwpdrgvpaadlailel..leka..rpskgpivvhcsagigrtgsv

IGLDRYIDRVLSKRDAD-VLDIVRDMRRARNFMIQFV--YLFL
. |.  .|..|. .  .    |.. .|  ||  ||    |||.
vmleyildqllagqiiedtdkilqkireqrnnsiqtdaqylfv

subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 98-324 2.2e-26 87.1 In-house 29-244 (281) alignment
Range on Protein: 98-324
Range on HMM: 29-244/281.0
ATASRSDANQHLNRYSNIVAYDATRVLVPKNKENF-NCDYVNANWIPSEG-PRKYIAAQGPVPASLVSFWQMVVEHDARLIVMLTNEIEGGKLKCHRYWP
.|.     |.. |||.|| . | .|| .  .  |    ||. ||.| |    | || .|||   .   ||.|. . ..  |||| . .|  . ||  |.|
ctvfnqpvnnkknrylnipcldisrvqlkvkmpnknstdyihanyirspflkrgyiltqgpkketradfwrmiwqenttaivmlcqfletnrekcaeyfp

DDNMAKashpqpvkkVKIGTYIVSFEGEESFPTYVHRKFKLYLEsGEARDVSQMAYTAWPDHGVPATTKELLgfrlAVKDQLKRLNCTPLIHCSAGVGRT
 .  .          ...  . ||.|      . |  ...|  | ||.| ...  .  |||  || ... .|     .  ...     |.|||||||||.
rnahcc.........lqfdklsvsyedstvnkslvttrlnlsye.getrlithwlwkewpdwqvpessevml....kilrkirarstppvihcsagvgrs

GTFIGLDRYIDRVLSKRD-ADVLDIVRDMR
||.. ..  .. . |.    |. .||  .|
gtlmaveialqsihshftlpdikqivshlr

PTPc_DSPc_SM00012 246-344 3.7e-25 83.5 In-house 2-103 (105) alignment
Range on Protein: 246-344
Range on HMM: 2-103/105.0
VSQMAYTAWPDHGVPATTKELLGFRLAVKDQLKRLN--CTPLIHCSAGVGRTGTFIGLDRYIDRVLSK-RDADVLDIVRDMRRARNFMIQFVYLFLVCLD
|... ||.||||||| .....| .  |||.. .  .     ..||||||||||||. ||  .... .. .  |...||. .|. |. |.|. . .|....
vkhyhytgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqylflyr

AM
|.
al

subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 98-340 4.4e-25 83.2 In-house 25-251 (267) alignment
Range on Protein: 98-340
Range on HMM: 25-251/267.0
ATASRSDANQHLNRYSNIVAYDATRVLVPKNKENfncdYVNANWIPS-EGPRKYIAAQGPVPASLVSFWQMVVEHDARLIVMLTNEIEGgklKCHRYWPD
 . | .  ||  ||. . . || ||| . ...|.    |.|| .. . .  ...|. |.|.  .   |.... ...   ||.||.  ..   . ...|| 
isqsiaeknqernrlddnlpyddtrvilrtkeee....yinasyvegyktknafivtqdplkntitdfltvihdqkvpvivlltkvftd...nirlfwPP

dNMAKAshpqpvKKVKIGTYIVSFEGEESFPTYVHRKFKlyLESGEARDVSQMAYTAWPDHGVP-ATTKELLGfrLAVKDQLKRLNCTPLIHCSAGVGRT
 .|..|      || .  |   |.| ||     .  ..|  ..   |..|.   |  |          | |.|  .  |.||.  |   ...||.||||.
.kmgqa......kkyqdltvehslekeendyqiitlelk..fknesahnvtlyyykkwnintnnkpylkplfg..ilaknqlengnrPlvvacsdGvGrs

GTFIGLDRYIDRVLSKRDADVLDIVRDMRRARNFMIQFVYLFLVC
|||. .|  ..|.     .|. | .| .|  |  ...    .. .
Gtflvidsqleraktegvsdifdflrkirsqriglvdtkeryiyi

subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 103-334 4.4e-25 82.9 In-house 49-276 (310) alignment
Range on Protein: 103-334
Range on HMM: 49-276/310.0
SDANQHLNRYSNIVAYDATRVLVPKNKENFNcDYVNANWIPSEGPRK-YIAAQGPVPASLVSFWQMVVEHDARLIVMLTNEIEGGKLKCHRYWPDDNMAK
   . | ||||..|  |..|| .  .|  .. ||. ||.. ..  |. .| .|||.  ... ||.|. .  |  |..| .  | |. ||  |||   ...
ykkymhknrysdvvcldtsrvklkidksrye.dyihanyvktnylrstficsqgplqhtiidfwrmifqeraesilllckvgeegrpkcvgywpslgvte

ASHpqPVKKVKIGTYIVSFEGEESFPTYVHRKFKLYLESGEA--RDVSQMAYTAWPDHGVPATTKELLGFRLAVkdQLKRLNCtpLIHCSAGVGRTGTFI
.     ..  ...     ||  .   |.|  .  .  .  .     || . .  ||| |||      .  ||    |..   |  ..|||||..|... .
tyg..cirvtnlsesseefeicnlavtfvpdnvpvdeqpanlkelrvslikwpnwpdrgvpdekchtvpqrlla..qvrhgpc..vvhcsagkdrlyvvv

GLDRYIDRVLSKRDADVLDIVRDMRRARNFMIQFV
 |.  ||..      |. ... .... |   ||  
alklkidkldrglkvdaeevktellksraiciqte

subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 107-361 5.8e-25 82.6 In-house 44-287 (312) alignment
Range on Protein: 107-361
Range on HMM: 44-287/312.0
QHLNRYSNIVAYDATRVLVPkNKENFncdYVNANWIP-SEGPRKYIAAQGPVPASLVSFWQMVVEHDARLIVMLTNEIEGGKLKCHRYWPDDNMAKASHP
. |||| ||  .|  |  .    |||   |. ||..     | .....|||.  . . |||...   .  |..|.  .| |  || .|  |         
kdlnrypniqcwdrgrftla.gdenf...yihanfvkictkperfvctqgplentcthfwqlalslgstsiillcgfvedgsekcakyisdivgfvdled

QPVKkVKIGTYIVsfEGEESFPTYVHRKFKLYLE-SGEARDVSQMAYTAWPDHGVPATTKELLGFRLAVKDQLKRLnctpLIHCSAGVGRTGTFIGLDRY
. |   .  | |    |  |     || .|. .  .|.   . .  ...|||||.| .    | .  ||| . | .    . |||||||||||.. ..  
hrvy.teycteie..iggkskdkithrvlkvvvkatgqesklnhyqwaswpdhgmpdscdtalrllsavkkdkkpv....iahcsagvgrtgtlaliesm

IDRVLSKRDADVLDIVRDMRRARNFMIQFVYLFLVCLDAMdqLEKLLDKYLALATKS
|  .   |  .| |.   .|. |   .. .  .. .| ..  || |  | |    . 
iaalrhprkqnvkdsfvllrkdrarsvrvfpqyvyalrcv..leflyskglykrneq

subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 106-337 2.2e-22 74.5 In-house 43-264 (288) alignment
Range on Protein: 106-337
Range on HMM: 43-264/288.0
NQHLNRYSNIVAYDATRVLVPknkenFNCD-YVNANWIPSEGP-RKYIAAQGPVPASLVSFWQMVVEHDARLIVMLTNEIEGGKLKCHRYWPDDNMAKAS
|   .|| |.   |.||| .       ..| |..|| ..|.   |. | || |. . .  .|.|..| | . ||||.. .| || |   |.|     || 
nptrdryenlprcditrvkls.....ddpdfyiaanvvssakykrrlicaqaPlngtieelWkmllesdveyivmlcellekGkeksaeyfPsklGekar

HPQPVKKVKIGTyivsfegeESFPTYVHRKFKLYLESGEARD-VSQMAYTAWPDHGVPATTKELLgfRlaVKDQLKRLNCTPLIHCSAGVGRTGTFIGLD
  .  . ||           .     |.       . || .  | .. .  |.|.|||   .  |  |  . . || |.   ..|.|||||||||.|   
igrlctvvkkkr........adidklvkvsllriskegeekvivkilhlleWdddgvPenylspl..r..llevlkslqkPivvhssaGvGrtgtlilil

RYIDRVLSKRDADVLDIVRDMRRARNFMIQ----FVYLF
  .. . .. .  .  ..  .|  |   ||    ..|..
ialeslrlddflgirsllaklreerfkaiqtemqylyvh

subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 158-339 6.5e-22 72.3 In-house 101-283 (302) alignment
Range on Protein: 158-339
Range on HMM: 101-283/302.0
PASLVSFWQMVVEHDARLIVMLTNEIEGGKLKCHRYWPDDNMAKASHP-QPVKKVKIGTYIVSFEGEESFPTYVHRKFKLYLESGEARDVSQMAYTAWPD
  .|  .| .. ...  ..| |.. .|... ||  |. |.   .       || |.. | .  |   .||  |         ..   . |. .|..||||
kstlekhwalieqynvaivvqlcsfvedeekkcaeyysdkvggelkfgrytvktvsvktdleeftdkksfklytveiknekkkkkvkktvdilafsawpd

HGVPATTKELLGFrLAVKDQLKRlncTPLIHCSAGVGRTGTFIGLDRYIDRVLSKRDADVLDIVRDMRRARNFMIQ----FVYLFLV
|| |. ..  |   |   .  |.   . |.|||||||||||.. .   |.  . |. .|.|.||  .|. |   .|     .||.|.
hGapkeaytaldi.lkfcesykk...nvlvhcsaGvGrtGtlvaikyGiqlcskkkvtdllsivlpvrqcryGavqdeqqliylllc

subfamily_CG42327_pd Subfamily CG42327 107-279 1.1e-21 71.8 In-house 29-196 (319) alignment
Range on Protein: 107-279
Range on HMM: 29-196/319.0
QHLNRYSNIVAYDATRVLVPKNKENFNCDYVNANWI--PSEGPRKYIAAQGPVPASLVSFWQMVVEHDARLIVMLTNEIEGGKLKCHRYWPDDNMAKAsh
.  .|. |.|    ||| ...  .. .  |..|...  . . |  ||||| .   |  .||..| |  .| || ||.  | |  .| .|.|  .  .   
kdksrvinvvPlPetrvvlqrigdddkdeyldasyvrGyddapnsyiaaqvsledsssdfwrtvweqqsrvivqltdlselGikvcaeylPtketldn..

pqpvkKVKIGTYIVSFEGEESFPTYVHRKFKL-YLESGEARDVSQMAYtAWPDHGVPATTKELLGFRLAVKDQLKR
     .   | . |.. | |.   |.   . |  ..  |.|...   |  |.. .|||  . |.   | |.. || 
.....tslyGdilvtlkgrevkdryaistlllkrvdkeesrelthywy.kwleaevPaeeaaliamllevrsslks

subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 109-200 1.3e-19 65.1 In-house 50-156 (350) alignment
Range on Protein: 109-200
Range on HMM: 50-156/350.0
LNRYSNIVAYDATRVLVP--------KNKENFNCDYVNANWIPSE-------GPRKYIAAQGPVPASLVSFWQMVVEHDARLIVMLTNEIEGGKLKCHRY
 |||.||. |. .|| ..        |..     ||.|||..  .          ||||.|.|.|  .  |...... . ..|..||...| .  ||.||
knrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvkvilsltsdvelnlekcyrY

WPDDNMA
|.. .. 
Wqegsyd

0048076 (Phosphotyrosine protein) phosphatases II 219-338 1.7e-18 62.2 In-house 15-133 (145) alignment
Range on Protein: 219-338
Range on HMM: 15-133/145.0
SFEGEESFPTYVHRKFKL-----YLESGEARDVSQMAYTAWPDHGVPATTKELLGFRLAVKDQLKRlNCTPLIHCSAGVGRTGTFIGLDRYIDrvlskRD
|.   ...... . ....     . .... | . |  |. |||||||  .. || |  .... ||. ..  |.|||||||||||.....  .      ..
slptaldlellkdlgittvlnltselellerlgiqylylpwpDhgvpdllellleflefieealke.ggpvlVHCsaGvgRtgtlvaaylmll.....lg

ADVLDIVRDMRRARNFMIQFVYLFL
 .. .... .|..| .... .  . 
vsleealelvrsqrpgavpnpgqlr

0048179 (Phosphotyrosine protein) phosphatases II 232-335 2.1e-17 58.7 In-house 48-132 (144) alignment
Range on Protein: 232-335
Range on HMM: 48-132/144.0
RkfklylesgeardVSQMAYTAWPDHGVPATTKELLGFRLAVKDQLKrLNCTPLIHCSAGVGRTGTFIGLDRYIdrvlsKRDADVLDIVRDMRRARNFMI
              . |  .. |||||||  .. || |  .... |.  ..  |.|||||||||||.. ... .     |.. .. .... .|..| ...
e.............giqylhlpwpDhgvpdllellleflefieeale.eggpvlVHCsaGvgRtgtlvaaylmk.....klglsleealalvrsrrpgav

QFVY
.   
pnpg

subfamily_egg_pd Subfamily egg 99-338 1.2e-14 48.7 In-house 33-260 (307) alignment
Range on Protein: 99-338
Range on HMM: 33-260/307.0
TASRSDANQHLNRYSNIVAYDATRVLVPKNKENFNCDYVNANWIPSeGP--RKYIAAQGPVPASLVSFWQMVVEHDARLIVMLTNEIEGgkLKCHRYWPD
| . || |..  |   .   | .|| .  ..  .  |.. || .   .|   ..| || |.  .   ||.|| . . . |||||   |    .|. ||| 
ttaasdnnlekarskrvhckdssrvklelrrGqylddfihanrvkG.kpllnefilaqaplkntvddfwrmvfqeevqyivmltsrkes..erceyywpk

dnmakaSHPQPVKKVKIGTYIVSFEGEeSFPTYVHRKFKLYLeSGEARDVSQMAYTAWpdhGVPATTKelLGFRLAVKDQLKRLNCTPLIHCSAGVGRTG
      .. .... |  .  | ... . | .  . |  || |  |  ..   . .  .    |  ...  . . | |  .|..|    ....  || ...
......aesdslvtvpGslrienlkvd.skadplfrvtklkl.vGgddeerflehwqg...dvnnssd..vysplrvlrklrnlskpvvvqdilGvskaa

TFIGLDRYIDRVLSK--RDADVLDIVRDMRRARNFMIQFVYLFL
|.. ..  .  .|        ||  |  .|. |.. .. | |.|
tlvaieiallsllrGpitkslvlravvflrlrrrlsvesvllyl

subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 146-331 3e-14 47.7 In-house 3-187 (199) alignment
Range on Protein: 146-331
Range on HMM: 3-187/199.0
GPRKYIAAQGPVPASLVSFWQMVVEHDARLIVMLTNEIEGGKLKCHRYWPDDNMAKASHpqpvKKVKIGTYIVSFEGEESFPTYVHRKFKlyLESGEARD
| |.|||.| |.  ..  ||||| |  .  |||. ..    .     |||  . . . .      . . |  .. . . .  . .  .         .|.
gqrryiatqhplretmadfwqmvwetgsghivmvnddqknkeadypfywpttesgtgky....gslsvttktittkpdytitaliltnnt..tappstre

VSQMAYTAWPDHGVPATTkELLGFRLAVKDQLKRLN---CTP-LIHCSAGVGRTGTFIGLDRYIDRV-LSKRD-ADVLDIVRDMRRARNFMI
.|.  .|.| ..  |  .  ..|| .| ..  |. .    .| ..||| | | || |. ||  .     ||    |.... . .|.||  .|
ishyqftswkekttpnva.lfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgii

subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 160-336 3.2e-14 47.6 In-house 40-173 (255) alignment
Range on Protein: 160-336
Range on HMM: 40-173/255.0
SLVSFWQMVVEHDARLIVMLTNEIEGGKLKCHRYWPDDNMAKashpQPVKKVKIGTYIvsfegeeSFPTYVHRKFKLYLESG---EARDVSQMAYTAWPD
..  |.|..|  ..  .|||..  | |. ||..|.| .   |    . ...|.. |         |    | |  .. .. |   ....|    |. |..
tvdkfyqtivqtktevvvmlcdfaeegvekcssyfplekdek....lkladvnvtttk.......ssadvvlrtleitstlgekkkthtvkhysykGWie

HGVPATTKELLGFRLAVKDQlKRLnctpLIHCSAGVGRTGTFIgldryidrvlskrdadvldivrdmrrarnfMIQFVYL
.  |  ..|.|    .|.|  | .    ..|||.|.||. .|.                              ....|| 
knaPelareilnilkvvrds.ksv....vvhCstGiGrsaafv..............................laelvyq

subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 146-331 3.9e-14 47.3 In-house 2-186 (198) alignment
Range on Protein: 146-331
Range on HMM: 2-186/198.0
GPRKYIAAQGPVPASLVSFWQMVVEHDARLIVMLTNEIEGGKLKCHRYWPDDNMAKASHpqpvKKVKIGTYIVSFEGEESFPTYVHRKFKlyLESGEARD
| |.|||.| |.  .|  ||||| |  .  |||. ..    .     |||  . . . .      . . |  .. . . .  . .  .         .|.
gqrryiatqhplretladfwqmvwetgsghivmvnddqknkeadypfywpttesgtgky....gslsvttktittkpdytitaliltnnt..tappstre

VSQMAYTAWPDHGVPATTkELLGFRLAVKDQLKRLN---CTP-LIHCSAGVGRTGTFIGLDRYIDRV-LSKRD-ADVLDIVRDMRRARNFMI
.|.  .|.| ..  |  .  ..|| .| ..  |. .    .| ..||| | | || |. ||  .     ||    |.... . .|.||  .|
ishyqftswkekttpnva.lfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgii

subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 237-342 2.9e-13 44.0 In-house 82-188 (440) alignment
Range on Protein: 237-342
Range on HMM: 82-188/440.0
YLESGEARDVSQMAYTAWPDHGVPATTKELLGFRLAVKD-QLKRLNCTPLIHCSAGVGRTGTFIGLDRYIDRVLSKRDADVLDIVRDMRRARNFMIQFVY
|... |.| . |. | .|||.|||  .  .| .   |.. | |  |   |.|||||.||||  | .|  .  .    . |.. ..  ||  |  |.|   
yingiesrtlkqyhyqgwpdkgvpkfagpvlkmiqdvnesqekagngpllvhcsagagrtgviiavdsilreakrsdqidifsfinsmrnnrpqmvqtpe

LFLVCLD
 . .  .
qyafvhe

subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 116-338 5.6e-12 40.4 In-house 28-251 (290) alignment
Range on Protein: 116-338
Range on HMM: 28-251/290.0
VAYDATRVLVPKNKENFNCDYVNANWIPSEGPRKYIAAQGPVPAS-------LVSFWQMVVEHDARLIVMLTNEIEGGKL----KCHRYWPDDNMakash
    ||||     .. || ||. || .      . |. | |  .        . .|| |. .  .. .||| .  |  .      | .| |.        
pLveatrvvLkgygkrfnddyiHAnrvtcpnglrliltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCakYvpesvg.....

pqpvKKVKIGTYIVSFEGEESFPTYVHRKFKLYLESGEARDVSQMAYTAWPDHGVPATTKELLgfrlAVKDQLKRLNCTPLIHCSAGVGRTGTFIGLDRY
    ...|..   |.    |      .|.  .  . .|   |    .  | .  |. .|| ||    .. ...|  . . ..||  |. |  ..  ..  
....eelkfkgltvkCkskekeddvetRelvvkfddeeeftvtHsllkgWnklnvqedtktll....sliqkvkasktpvivHcvdGiSrsAalaaiilg

IDRVL----SKRDADVLDIVRDMRrARNFMIQFVYLFL
   .     |   .|||. .| .| |  .. .  . | 
yQkiaetsgsvkledvlkalrkqr.alaitsalelafv

subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 110-200 8.6e-12 39.0 In-house 52-159 (349) alignment
Range on Protein: 110-200
Range on HMM: 52-159/349.0
NRYSNIVAYDATRVLVPKNKEN--------------FNCDYVNANWIPS---EGPRKYIAAQGPVPASLVSFWQMVVEHDARLIVMLTNEIEGGKLKCHR
|||..|. |. .|| ..|  ..                 ||.|||..     .  .|||| | |.|...  |.....    .|.. |... | .  ||..
nrykdilPyehsrvklkkslksskvikastsesdsgklddyinanylkltrisvekkyiatqaPlPstvddfykvillngvklvlsLnddkelslekcdi

YWPDDNMA
|| . . .
ywqelsys

subfamily_Sponge-PTP3_pd Subfamily Sponge-PTP3 74-155 4.8e-11 36.7 In-house 16-95 (95) alignment
Range on Protein: 74-155
Range on HMM: 16-95/95.0
AHSANNNAGFIETFTSIRDGLGSAATASRSDANQHLNRYSNIVAYDATRVLVPKNKenfNCDYVNANWIPSEGPR-KYIAAQG
   .| .  | . | ||    |.. |.  |.||   ||. ||. |||||| .  ..   . ||.|| ..     .  ||||||
emhsnsdqefdnefksismtsgapytvgsseanipknrflnifpydatrvvlttkr...dsdyinacfvdgyarkncyiaaqg

subfamily_eak_pd Subfamily eak 106-308 5e-11 36.6 In-house 52-263 (332) alignment
Range on Protein: 106-308
Range on HMM: 52-263/332.0
NQHLNrYSNIVAYDATRVLVPKNKENFNcDYVNANWIP-SEGPRKYIAAQGPVPASLVSFWQMVVEHDARLIVMLTNEIEGGKLKCHRYWPDDN--MAKA
. . |   .|| ||   | .   . | .  |.||  .  ||  |||| .  .    .  |||||.|  .  ||.| ...| .  |  .|.||.     | 
avnrn.vvkivpydrylvrltssqlnrl.GyinaslaefsevGrkyiltGiasedkvfafwqmvleqkspaivqlledvelkleksdkyfpdktreelkf

SHPQP-----VKKVKIGTYIVSF-EGEESFpTYVHRKFKLYLESGEARDVSQMAY-TAWPDHGVPATTKEL-LGFRLAVKDQLK-RLNCTPLIHCSAGVG
 . .      ||. .. |  .    |.|.     | |.  . |    .    .|.  .  . ||.         ..  .|   .     .|.| .. |  
GildverkefvkrniletrllelskGneth.rvlhykvfGwtettlpkyedflalrkvmkevGvlllivmksallsstlkkyihtppsfapiiqsarGsa

RTGTFIGLDRYIDRV
|.|.|. .|  |  .
raGvfvvidllirli

subfamily_hpo-7_pd Subfamily hpo-7 162-306 7.1e-11 36.5 In-house 48-179 (263) alignment
Range on Protein: 162-306
Range on HMM: 48-179/263.0
VSFWQMVVEHDARLIVMLTNEIEGGKLKCHRYWPDDNMAKashpQPVKKVKIGTYIVSFegeesfpTYVH--RKFKLYLE-SGEARDVSQMAYTAWPDHG
 .|.|..|   .  .|||..  | |. || .|.| .   |    | ...|.. |  |           .   ...  .|.   . ..| .  |. |... 
dkfyqtivqtktevvvmLcDfneegvekcssyfPlekdek....qklanvnvcttkvqs.......dvllktlellstlgeKkkthtvkhysykgWiekn

VPATTKELLGFRLAVKDQlKRLnctpLIHCSAGVGRTGTFIGLDRYID
 |  ..| |    ....  |.|     .|||.|.||.  |   .    
dpelareilnilkvarns.ksl....vvhcstGiGrsaafsvaElvyq

subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 86-334 1.2e-10 35.5 In-house 27-265 (303) alignment
Range on Protein: 86-334
Range on HMM: 27-265/303.0
TFTSIRDGLGSAATASRSDANQHLNRYSNIVAYDATRVLVPknkenfNCDYVNANWIPSEGPRKYIAAQGPVPASLVSFWQMVVEHDARLIVMLTNEIEG
 |  .   |    .  .   | . ||. ...  | ..| .       .  |. |...  .  .| | .| |.. .   ||||..|   . ...|  . | 
efekvvsylppsvsknqfvknmdknrfvdvicldhskvkls......dssyihasyleldsskkailtqlplshtaadfwqmiieqkvkcvlllltdsey

GKLKCHRYWPDDNMAKASHPqpvKKVKIGTyivsFEGEESFPTYVHRKfkLYLESGEARDVSQ-MAYTAWPDHGVPAT-TKELLGFRLAVKDQLKRL-NC
 ||  .  .| ..          . ...|     |   |    .| .   | .  |. .   .   | |||   .|.  . ...     ..  |..  ..
dklggdsvfprnqdflkfee...rsirvge....fkrvelgdgwvlkv..lsvsngdyksflhvhhykawphnsipsdgspkfvkqiwqlqsvlrkysds

TPLIHCS-AGVGRTGTFIGLDRYiDRVLsKRDADVLDIVRDMRRARNFMIQ---FV
|| .. | .|.||.|||  ..      | . .   ||.|. .   ||  ..    .
tptvymslsgcgragtfalfeta.hlsl.hseqasldlvkclenvrngrlhavqnl

subfamily_Sponge-PTP-7_pd Subfamily Sponge-PTP-7 286-344 7.9e-10 33.0 In-house 3-61 (69) alignment
Range on Protein: 286-344
Range on HMM: 3-61/69.0
IHCSAGVGRTGTFIGLDRYIDRVLSKRDADVLDIVRDMRRARNFMIQFVYLFLVCLDAM
.|||.| ||||||| .   . |. |..  |... |. ||. |  |.     ..   ||.
vhcssgtgrtgtfiaimvemarikseklvdifnnvqymrkcrpmmvmneieyifihdal

subfamily_Sponge-PTP7_pd Subfamily Sponge-PTP7 286-344 1.1e-09 32.5 In-house 2-60 (69) alignment
Range on Protein: 286-344
Range on HMM: 2-60/69.0
IHCSAGVGRTGTFIGLDRYIDRVLSKRDADVLDIVRDMRRARNFMIQFVYLFLVCLDAM
.|||.| ||||||| .   . |. |..  |... |. ||. |  |.     ..   ||.
vhcssGtGrtGtfiaimvemarikseklvdifnnvqymrkcrpmmvmneneymfihdal

0038934 (Phosphotyrosine protein) phosphatases II 252-326 1.9e-08 29.7 In-house 85-158 (194) alignment
Range on Protein: 252-326
Range on HMM: 85-158/194.0
TAWPDHGVPATTKELLGFRLAVKDQLKRL-NCTPLIHCSAGVGRTGTFIGldRYIDRVLSKRDADVLDIVRDMRRA
  .||.|.. ... || |  .|.. |..  ... ..|| ||.|||||...  .|.  .|     . ....|..|. 
lpfpddgtvPsleillrfldlvdeflnedpggvvaVHCkaGlgRtGtlva..aYLiyrlgmsaeeAialfrekRpg

subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 282-348 9e-08 26.2 In-house 262-344 (350) alignment
Range on Protein: 282-348
Range on HMM: 262-344/350.0
C-TPLIHCSAGVGRTGTFIGLDRYID--RVL---------SKRDADV----LDIVRDMRRARNFMIQFVYLFLVCLDAMDQLE
  . |.|||||||||||.. ||  .    .|         ... | .      ||  .|. |  |.| .  |... .|.  . 
sspilvhCsaGvGrtGtlvtlDsllsdfeilenltkesrkldvaaktrDlisiivnelrkqrismvqnldqfifiYeallfyf

subfamily_CG42327_pd Subfamily CG42327 286-332 7e-07 23.2 In-house 252-299 (319) alignment
Range on Protein: 286-332
Range on HMM: 252-299/319.0
IHCSAGVGRTGTFIGLDRYIDRVL-SKRDADVLDIVRDMRRARNFMIQ
.||| ||||||. |  |  | ..  |||  |. ..|  .|| |   ..
vhcsdGvGrtGlviasdiairsleeskrsvdiPqlvssvrrdrasavl

subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 282-313 1.6e-06 21.7 In-house 266-296 (349) alignment
Range on Protein: 282-313
Range on HMM: 266-296/349.0
CTPLIHCSAGVGRTGTFIGLDRYIDrVLSKRD
 | |.||||| ||||... ||  .. .|.   
stllvhcsaGcGrtGvlvtldllls.ileplq

subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 82-143 3e-06 20.8 In-house 23-84 (440) alignment
Range on Protein: 82-143
Range on HMM: 23-84/440.0
GFIETFTSIRDGLGSAATASRSDANQHLNRYSNIVAYDATRVLVPKNKENFNCDYVNANWIP
 | . .. .  || . .  .    |.  ||| ||.||| .||.. . |   . ||.|| .| 
afedewsllpsglsqpsdiaslpnnkvknryrnilaydhsrvmleevkgvpdsdyinasyin

subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 99-190 3e-06 21.0 In-house 30-127 (347) alignment
Range on Protein: 99-190
Range on HMM: 30-127/347.0
TASRSDANQHLNRYSNIVAYDATRV-LVPKNKENFNCD----YVNANWIPSE-GPRKYIAAQGPVPASLVSFWQMVVEHDARLIVMLTNEIEGGKLKC
|..  . .   ||  .    ||||| | |.. .| ..|    |.||  |  .   ..|| .| |.| ..  ||.||       .| . . |.   .. 
tsvewekslsknrskdvklidatrvvlspeksknsraddvetyinashikfdnaskeyiltqyplpdtvrdfwkmvsvtkvtqvvtifepikdeaiee

PTEN_1 252-299 9e-06 20.6 In-house 100-148 (196) alignment
Range on Protein: 252-299
Range on HMM: 100-148/196.0
TAWPDHGVPATTKeLLGFRLAVKDQLKRLNC--TPLIHCSAGVGRTGTFI
  ..|||.|   . |. .   ....|.....  . |.|| ||.||.|| .
fpieDhgapslse.lfdicksfiewllsdpngnvVlVHCkaGlgRsGtvv