Gene MbrePTP-sf2-1 in Monosiga brevicollis

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily MbrePTP-sf2
Protein sequence
ID Type Fasta BLAST phosphatome Note
MbreP039_AA protein Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 1-220 9.5e-103 337.9 In-house 35-255 (270) alignment 
Range on Protein: 1-220
Range on HMM: 35-255/270.0
TRVVLPRIHDDPESEYYNANWVRGADGNPKAYVAAMGPLPATLTHFWRTIWESNVSAIIMATGLIEKGKTKCERYWPAEVDGKTAMHFGDIVVLSVSEAK
|||.|.....|....|.|||.|||.||..|.|.|||||||.||..|||.|||..|.||.|.||| |||..|||||||||.. |.....|.| ||..||.|
tRvrleeleedsataYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkgrkkCerYWpaepkekvkledgkikvlalseek

AKGYIFTQLKVVRHGESRRIGHFWYNTWPDHGVPRDAERSLYPDSVLGLLHTVHKWNSKFKDQ-PTLVHCSAGIGRTGTLIVIDHCRQLLKTQMRADPLA
..|||.|.|.. ..||.||. ||||||||||||||....||..|..| .|..|.......... |.|||||||.|||||||..|.. .||......|.||
eegyiltrlrleekgeerrlvHfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkaePllvHcsaGvgRtGtlialDiavrlLeetkkvdvla

IIEAVRQDRPALVQHLQQVLH
|||..|.||.||||| .|. .
iieelRkdRmalvqhpeqyef
0050432 (Phosphotyrosine protein) phosphatases II 1-218 1.5e-66 220.2 In-house 83-288 (308) alignment 
Range on Protein: 1-218
Range on HMM: 83-288/308.0
TRVVLprihdDPESEYYNANWVRGAD-GNPKAYVAAMGPLPATLTHFWRTIWESNVSAIIMATGLIEKGKTKCERYWPAEVDGkTAMHFGDIVVLSVSEA
.||.|     |..| |.||..|.| . ..|....|. |||| |. .||| .|| ||. |.| | |.|.|. ||..||| |..| . ...|...|  .|| 
sRVkl.....degsdYInAsyvdgyssklprkfIatqgPlpntvedFwrmvweqnvrvIvmLtklvengrekcaqYwplelgg.gsleygkftvtllsee

KAKGYIFTQLKVVR--HGESRRIGHFWYNTWPDHGVPRDaerslyPDSVLGLLHTVHKWNskfKDQPTLVHCSAGIGRTGTLIVIDHCRQLLKTQMRADP
. ..|. ..|...    ||||.. ||.| .||||||| .      |...| .|. |.|..   .. |..||||||.|||||.|..|.. ..|... . |.
vlddytvrtleltnlgdgesrtvthfhytnWpdhgvPps......peilldflelvrksl...pggpivVHCsaGvGRtGtfialdllleqlekeggvdv

LAIIEAVRQDRPALVQHLQQV
. ..  .|. ||  || ..| 
feavkklReqRpgmvqtpeqy
0051299 (Phosphotyrosine protein) phosphatases II 1-218 4e-65 215.5 In-house 64-275 (288) alignment 
Range on Protein: 1-218
Range on HMM: 64-275/288.0
TRVVLPRIHDDPESEYYNANWVRGADGNPKaYVAAMGPLPATLTHFWRTIWESNVSAIIMATGLIEKGKTKCERYWPAevdgKTAMHFGDIVVLSVSEAK
.||.|  ......| |.||....| . . | ..|. |||| |. .||| .|| ||. |.| |.|.|.|..||..|||     .. . .|||.|  .|| .
sRVkLsvldgvegsdYinAsyidgynlkrk.fIatqgPlpntvedFWrmvweqnvrvIvmltklvelgrekcaqYwpl....ggsltygditvtllseev

AKGYIFTQLKVV------RHGESRRIGHFWYNTWPDHGVPRdaerslYPDSVLGLLHTVHKWNSkFKDQPTLVHCSAGIGRTGTLIVIDHCRQLLKTQMR
 ..|. ..|.|.       .||||.. ||.| .|||||||       .|...| .|. |.|...  .. |..||||||.|||||.|..|.. ..|... .
lddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpd......spellldflrlvrkala.sgggpvvVHCsaGvgRtgtfialdllleqlekegg

ADPLAIIEAVRQDRPALVQHLQQV
 |.| ... .|. || .|| ..| 
vdvleavkrlreqRpgmvqtpeqy
subfamily_PTPRD_pd Subfamily PTPRD 1-217 1.2e-64 213.9 In-house 63-269 (564) alignment 
Range on Protein: 1-217
Range on HMM: 63-269/564.0
TRVVLPRIHDDPESEYYNANWVRGADgNPKAYVAAMGPLPATLTHFWRTIWESNVSAIIMATGLIEKGKTKCERYWPAEvdGktAMHFGDIVVLSVSEAK
.|||| ... |..|.| ||... | . ..|||.|. |||. |.  ||| .|| |.| |.| | | ||||.||..|||..  |    ..|...|  ..| .
sRVvLskvegdegsDYINAsfidgyr.krkayIAtqgPlaetiedFWRmvweqnsstiVmltkleEkgkvkchkYWPek..g..tetygeltVtleeeee

AKGYIFTQLKV--VRHGESRRIGHFWYNTWPDHGVPRDAerslypDSVLGLLHTVHKWNsKFKDQPTLVHCSAGIGRTGTLIVIDHCRQLLKTQMRADPL
 . |.....|.   .. ||| . .| .  |||||||  |       |.| |...|...| . . .|..||||||.||||| |||| . . .|..   |  
ladyeirtfklkkkkssesreVrqFhFtsWPdhgvpesa......tslLdlirkvraln.epdagPivVhCSaGVGRTGtfividamlerikeektvDiy

AIIEAVRQDRPALVQHLQQ
 ...|.|..|.|.||  .|
qyvkalrkqRnamVqteeQ
0046845 (Phosphotyrosine protein) phosphatases II 1-218 1.3e-64 213.7 In-house 43-263 (284) alignment 
Range on Protein: 1-218
Range on HMM: 43-263/284.0
TRVVLPRIHDD-PESEYYNANWVRGAD----GNPKAYVAAMGPLPATLTHFWRTIWESNVSAIIMATGLIEKGKTKCERYWPAEvdgKTAMHFGDIVVLS
.||.| ....| ..|.|.||..|.| |     ..|...|. |||| |. .||| .|| ||. |.| |.|.|.|..||..||| |   .. ...||. |  
sRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweqnvrvIVmltelvengrekcaqYwple...gevltygdftvtl

VSEAKAKGYIFTQLKVVR---HGESRRIGHFWYNTWPDHGVPRDaerslyPDSVLGLLHTVHKWNSK-FKDQPTLVHCSAGIGRTGTLIVIDHCRQLLKT
.|| . ..|. . |....    ||||.. ||.| .||||||| .      |...| .|..|......  .. |..||||||.|||||.|..|.. ..|..
lseevkddytvrtleltnlgytgesrtvthfhytswpdhgvpps......pedlleflrlvrellenlpgggpivVHCsaGvgRtGtfialdllleqlek

QM---RADPLAIIEAVRQDRPALVQHLQQV
.    . |.| ..  .|. ||  || |.| 
eglllgvdvleavkrlreqRpgmvqtleqy
subfamily_PTPRB_pd Subfamily PTPRB 1-225 6.4e-64 210.8 In-house 66-283 (293) alignment 
Range on Protein: 1-225
Range on HMM: 66-283/293.0
TRVVLPRIHDDPESEYYNANWVRGADgNPKAYVAAMGPLPATLTHFWRTIWESNVSAIIMATGLIEKGKTKCERYWPAEvdgKTAMHFGDIVVLSVSEAK
.|| |  ..|...|.| |||...|    |. ..|. |||| |. .||| .||...|.|.| | |.||||.|||.||||.   .... .||| |  |.| .
srvkLaalkdesgsDYinanyipgyn.sprefiatqGPlpetvddfWrmvwekkssiivmltqlvekgkvkCeeYWPad...eepvlyGdikvtlvaeee

AKGYIFTQLKVVRHGESRRIGHFWYNTWPDHGVPRDAerslypDSVLGLLHTVHKWN-SKFKDQPTLVHCSAGIGRTGTLIVIDHCRQLLKTQMRADPLA
 . ..  .||. .. |.|.. .. . .||||||| ..      ...| ...||...  .. ...|..||||||.|||||.| .|.  | ....   | ..
ledwvirelkiekekeerkvrqyhftsWpdhgvPekt......ktlldfvrtvreaiektaskrPivvhCsaGvGRtGtfialdrllqaieeedyvdifg

IIEAVRQDRPALVQHLQQ--VLHHGVSD
|. ..|..|  |||  .|  ..|. | |
ivaelReeRnllvqtekqYifihqcvld
subfamily_PTPN12_pd Subfamily PTPN12 1-224 1.6e-62 206.0 In-house 55-274 (290) alignment 
Range on Protein: 1-224
Range on HMM: 55-274/290.0
TRVVLPRIHDDPESEYYNANWVRGADGNpKAYVAAMGPLPATLTHFWRTIWESNVSAIIMATGLIEKGKTKCERYWPAEVDgkTAMHFGDIVVLSVSEAK
.||.| .|.....|.| |||...|..|. ..|.|| ||||.||. ||| ||| ||. ..||  ..| ||.||||||| |..  ....||.. |   .| .
srvelskieeeegsdYinanfikgvegk.leyiaaqgPLpktlddfWrmiweknveivvmaCrevelgkkkCerYWpeege..eelefgefevtleeeka

AK-GYIFTQLKVVRHGESRRIGHFWYNTWPDHGVPRDAerslypDSVLGLLHTVHKWNSkFKDQPTLVHCSAGIGRTGTLIVIDHCRQLLKTQMRADPL-
 . ...  .||| ...|||..  | |. |||||||. |      .|.| |...|.. ..  .|.| .||||||.|||||.|.||. |.|||... .. | 
vdddflirtLkveaqkesrkvyqfhYtaWPDhgvPssa......ksllelielvrelqe.sedaPlvvhCsaGvGrtGtiiaidyvrellkaekipeeld

--AIIEAVRQDRPALVQHLQQ--VLHHGVS
   ..  .|..|.||||  .|  .... | 
vfdlvlelrkqraalvqtkeqyelvykava
0040438 (Phosphotyrosine protein) phosphatases II 1-217 3.8e-62 205.7 In-house 58-264 (317) alignment 
Range on Protein: 1-217
Range on HMM: 58-264/317.0
TRVVLPRIHDDPESEYYNANWVRGADGNPKaYVAAMGPLPATLTHFWRTIWESNVSAIIMATGLIEKGKTKCERYWPAevdgKTAMHFGDIVVLSVSEAK
.||.|  .  |..| |.||..| | . ..| ..|. |||| |. .||| .|| .|. |.| | | |.|. ||..|||     .. ...||..|  .|| .
sRVkLsplggdldsdYInAsyvdgpnlkrk.fIatqgPlpntvedFwrmvweqgvtvivmLteleelgrekcaqYwpl....getltygdftvtllseee

AKGYIFTQLKVV--RHGESRRIGHFWYNTWPDHGVPRdaerslYPDSVLGLLHTVHKWNSkFKDQPTLVHCSAGIGRTGTLIVIDHCRQLLKTQMRADPL
 .|.. ..|.|.  ...|||.. ||.| .|||||||       .||..| .|. |.....  .. |.|||||||.|||||.|... . ..|.. .. |. 
lagitlrtlevedlgdsesrtvthfhytgWpdhgvpp......spdllldfleavreale.dpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdve

AIIEAVRQDRPALVQHLQQ
 ... .|. ||  || ..|
eavkelreqRpgavqtpeq
0039614 (Phosphotyrosine protein) phosphatases II 1-218 1e-60 201.1 In-house 71-278 (297) alignment 
Range on Protein: 1-218
Range on HMM: 71-278/297.0
TRVVLPRIHD-DPESEYYNANWVRGADGNPKAYVAAMGPLPATLTHFWRTIWESNVSAIIMATGLIEKGKtKCERYWPAEVDgktamHFGDIVVLSVSEA
.||.|  . . |..| |.||..| | | ......|. |||| |. .||| .|| .|..|.| | |.|.|. ||..||| |..      .||..|  ... 
srvklkpedgvdldsdYinAsyvdgydlltrkfIatqgPlpetvedFwrmvweqgvtvivmLtklvelgr.kcaqywpeegg.....tygdftvtllkve

KAKGYIFTQLKVVRHGESRRIGHFWYNTWPDHGVPRdaerslYPDSVLGLLHTVHKWNSKF-KDQPTLVHCSAGIGRTGTLIVIDHCRQLLKTQMRADPL
. .||. ..|.|...|||| . ||.|  |||||||       .....| .|. |......  |. |.|||||||.|||||.|... . ..|..  . |.|
hldgytvrtlevtnngesrtvthfqytgwpdhgvpp......slellleflelvrealaelpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvl

AIIEAVRQDRPALVQHLQQV
 ... .|. ||  || ..| 
eavkelreqRpgavqtpsqy
0047943 (Phosphotyrosine protein) phosphatases II 1-218 1.4e-60 200.5 In-house 53-261 (273) alignment 
Range on Protein: 1-218
Range on HMM: 53-261/273.0
TRVVLprihDDPESEYYNANWVRGADGNPKaYVAAMGPLPATLTHFWRTIWESNVSAIIMATGLIEKGKTKCERYWPAEVDGkTAMHFGDIVVLSVSEAK
.||.|    .|..| |.||..|.| . ..| ..|. |||| |. .||| .|| ||. |.| | |.|.|. ||..||| |... . . .|.. |  .|| .
srvkl....gdggsdyinAsyvdgynlkrk.fiatqgPlpntvedfwrmvweqnvrviVmLtelvelgrekcaqYwplegge.lsltygkftvtllseet

AKGYIFTQLKVVR--HGESRRIGHFWYNTWPDHGVPRdaerslYPDSVLGLLHTVHKWNSKF-KDQPTLVHCSAGIGRTGTLIVIDHCRQLLKTQMRADP
 ..|. ..|....   |||| . ||.| .|||||||       ...|.| ... |.|..... .. |..||||||.|||||.|..|.. ..|..  . |.
kddytvrtleltnlgtgesrtvthfhytgwpdhgvpp......slesllefielvrkalealpsngpvvVHCsaGvgRtgtfialdllldqlekeggvdv

LAIIEAVRQDRPALVQHLQQV
| ..  .|. ||  || ..| 
leavkllrsqRpgmvqtpeqy
0036941 (Phosphotyrosine protein) phosphatases II 1-218 2.3e-60 199.8 In-house 54-266 (297) alignment 
Range on Protein: 1-218
Range on HMM: 54-266/297.0
TRVVLprihDDPESEYYNANWVRGADGNPKaYVAAMGPLPATLTHFWRTIWESNVSAIIMATGLIEKGKTKCERYWPAEVDGKTAmhFGDIVVLSVSEAK
|||.|    ||..| |.||..| | | . | ..|. |||| |. .||| .|| ||. |.| | |.|.|. ||..||| |...     .||..|  .|. .
tRVkl....ddegsdYinAsyvdgydlkrk.fIatqgPlpntvedFWrmvweqnvtvIvmltelvelgrekcaqywpleegeslt..ygdftvtllsvev

--AKGYIFTQLKVVR--HGESRRIGHFWYNTWPDHGVPRdaerslYPDSVLGLLHTVHKWNSKF-KDQPTLVHCSAGIGRTGTLIVIDHCRQLLK---TQ
   ..|. ..|.|.    ||||.. ||.| .|||||||       .|.|.| ... |.|..... .. |.|||||||.||.||.|..| . |.|.   ..
vllddytlrtlevtdtgngesrtvthfhytgwpdhgvpe......spaslldfielvrkvlkllpsggpvlVHCsaGvgRsgtfiaadlmlqqledklke

MRADPLAIIEAVRQDRPALVQHLQQV
 . |.| ..  .|. ||  || |.| 
ggvdileavkklReqRpgavqtleqy
0045450 (Phosphotyrosine protein) phosphatases II 1-218 2.7e-59 196.7 In-house 70-293 (307) alignment 
Range on Protein: 1-218
Range on HMM: 70-293/307.0
TRVVLPRIHDD-PESEYYNANWV--------RGADGnPKAYVAAMGPLPATLTHFWRTIWESNVSAIIMATGLIEKGKTKCERYWPAEvdgKTAMHFGDI
|||.|  .... ..| |.||..|         | |  .....|. |||| |. .||| .|| .|..|.| |.|.|.|. || .||| |   .. . .|..
tRVklssldgsledsdYiNAsyvrvpllllldgydl.krkfIatqgPlpetvedFwrmlweqgvtvivmltelvelgrekcaqywPde...geeltygnf

VVLSVSEAKAKGYIFTQLKVV---RHGESRRIGHFWYNTWPDHGVPRdaerslYPDSVLGLLHTVHKWNSKF-KDQPTLVHCSAGIGRTGTLIVIDHCRQ
.|  .|| . .||. ..|.|      ||||.. ||.| .|||||||       .....| ... |.|....  |. |.|||||||.|||||.|... . .
tvtllseehldgytvrtlevtdldgtgesrtvthfhytgwpdhgvpp......sfeelldfieevrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlr

LLKTQMR---ADPLAIIEAVRQDRPALVQHLQQV
.|...      |.| ... .|. ||  || ..| 
qlekegtlldvdlleavkllreqRpgavqnpeqy
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 1-218 3.4e-59 195.2 In-house 56-267 (281) alignment 
Range on Protein: 1-218
Range on HMM: 56-267/281.0
TRVVLPRIHDDPESEYYNANWVRGADGnPKAYVAAMGPLPATLTHFWRTIWESNVSAIIMATGLIEKGKTKCERYWPaevDGKTAMHFGDIVVLSVSEAK
|||.. . ... ...| |||.| | .| .|.|.|. ||.||.|..||. .|| .||||.| |  ||.|| || ||||   |.......||..| |..|..
trvkvtpneenkntDYinanfvpgykg.ekeyiatqgPvPaslvafWqmvweqkvsaivmvtreieagklkChrYWP...ddnselkygdvtvkstaeee

AKGYIFTQLKV-VRHGESRRIGHFWYNTWPDHGVPRDAErslypdSVLGLLHTVHKWNSKFKDQPTLVHCSAGIGRTGTLIVIDHC-RQLLKTQMRADPL
 . ||  ..|.  ..||.|.. .. | .||||||| ...       .|.  . |.| ..| ...| ..|||||.||||| | .|   ... ... ..|. 
katyierkfkleresgetreveqlaytaWPdhGvPattk......ellefrkevlkltekktkaplvihCsaGvGrtGtyialDrlvkaveaeleeldvk

AIIEAVRQDRPALVQHLQQ--V
|... .|..|  .|| . |   
avvaelrkernlmvqtvvqyef
DSPc_SM00195 1-217 1.2e-58 193.8 In-house 41-250 (263) alignment 
Range on Protein: 1-217
Range on HMM: 41-250/263.0
TRVVLPRIHDDPESEYYNANWVRGAdGNPKAYVAAMGPLPATLTHFWRTIWESNVSAIIMATGLIEKGKTKCERYWPAEVdgKTAMHFGDIVVLSVSEAK
||| |........|.|.|||...||  ..|.|.|. |||| |. .|||..|| .|. |.| |   |.||.||.|||| |   .. . ||.| |  |.. |
trVklkkeekkegsdYINAnyikga.nkkkkyIatQgPlpstvedFWrmvweekvkiivmlteeeengkekcdrywpees..ggketfgkisvklvevek

AK-GYIFTQLKVVRHG--ESRRIGHFWYNTWPDHGVPrdaersLYPDSVLGLLHTVHKWNSKFkDQPTLVHCSAGIGRTGTLIVIDHCRQLLKTQMRADP
 |  .| ..|..  .|  |.|.. ...|..|||||||        ..||| ||..|.|..|.  ..|..||||||.|||||...|| . . |... . | 
kkdeiilrtleltkegkeetrkvtqyqyknWpdhgvp......dstksvlellravkksksts.sgpivVhCsaGvgRtgtfvtidiilskleeekkvdi

LAIIEAVRQDRPALVQHLQQ
 .|....|. || .|| |.|
feivkelRkqRpgmvqtleq
PTPc_SM00194 1-217 1.2e-58 193.8 In-house 41-250 (263) alignment 
Range on Protein: 1-217
Range on HMM: 41-250/263.0
TRVVLPRIHDDPESEYYNANWVRGAdGNPKAYVAAMGPLPATLTHFWRTIWESNVSAIIMATGLIEKGKTKCERYWPAEVdgKTAMHFGDIVVLSVSEAK
||| |........|.|.|||...||  ..|.|.|. |||| |. .|||..|| .|. |.| |   |.||.||.|||| |   .. . ||.| |  |.. |
trVklkkeekkegsdYINAnyikga.nkkkkyIatQgPlpstvedFWrmvweekvkiivmlteeeengkekcdrywpees..ggketfgkisvklvevek

AK-GYIFTQLKVVRHG--ESRRIGHFWYNTWPDHGVPrdaersLYPDSVLGLLHTVHKWNSKFkDQPTLVHCSAGIGRTGTLIVIDHCRQLLKTQMRADP
 |  .| ..|..  .|  |.|.. ...|..|||||||        ..||| ||..|.|..|.  ..|..||||||.|||||...|| . . |... . | 
kkdeiilrtleltkegkeetrkvtqyqyknWpdhgvp......dstksvlellravkksksts.sgpivVhCsaGvgRtgtfvtidiilskleeekkvdi

LAIIEAVRQDRPALVQHLQQ
 .|....|. || .|| |.|
feivkelRkqRpgmvqtleq
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 1-217 2.6e-58 192.3 In-house 43-256 (274) alignment 
Range on Protein: 1-217
Range on HMM: 43-256/274.0
TRVVL-PRIHDDPESEYYNANWVRGADGNPKAYVAAMGPLPATLTHFWRTIWESNVSAIIMATGLIEKGKTKCERYWPAEVDGKTAMHFGDIVVLSVSEA
.||.| ..  .|..|.| |||...| |.. |||||. |||| |.. ||| |.. .|. |.| | | |. ..||..|.| . | . . ..||. .  ..  
srvllesessededssyinanyikGydeeskayvatqGPlpntvadfWrmiyqeevqvivmltklkeaneqkCavyfPdaedyeiserygdveikvekiv

KAKGYIFTQLKVVRHGESRRIGHFWYNTWPDHGVPRDAErslypdSVLGLLHTVHKWNSKFKDQ--PTLVHCSAGIGRTGTLIVIDHCRQLLKTQMRADP
. ..|  ..| .    ..|.. |.||  |||| .|.||.      ..| |.. |.. ... . .  |..|||||||||||  | |. . . |. ..  | 
erndysvrklvlkylerersvkhywytdWPdhksPddan......tlldlvleveesreeenaklapvvvhCsaGiGrtGcfiaisiavrqlreeivvdv

LAIIEAVRQDRPALVQHLQQ
| |.  .|.||  .||  .|
lkivcnlrldrGGmvqtseq
0043336 (Phosphotyrosine protein) phosphatases II 1-218 2.4e-57 189.9 In-house 60-266 (278) alignment 
Range on Protein: 1-218
Range on HMM: 60-266/278.0
TRVVLPRIHDDPESEYYNANWVRGADGNPKaYVAAMGPLPATLTHFWRTIWESNVSAIIMATGLIEKGKTKCERYWPaevdgKTAMHFGDIVVLSVSEAK
.||.|  .  |. | |.||..| | . ..| ..|. |||| |. .||| .|| .|. |.| |.| |.|..|| .|||     .. . .||..|  ..| .
srvklsllggdldsdYinAsyvdgynvprk.fiatqgPlpetvedFwrmvwelgvttivmLtelvelgrvkcaqYwp.....ggsltygdftvtllkeeh

AKGYIFTQLKVV--RHGESRRIGHFWYNTWPDHGVPRdaerslYPDSVLGLLHTVHKWNSkFKDQPTLVHCSAGIGRTGTLIVIDHCRQLLKTQMRADPL
 ..|. ..|.|.  ..|||| . |..|  |||||||        ....| .|..|.....  .. |.|||||||.|||||.|... . ..|..  . |..
lddytvrtlevtnlgdgesrtvthyhylgwpdhgvpe......slsllldflkavreale.dsngpvlVHCsaGvgRTGtfialyllleqlekeggvdle

AIIEAVRQDRPALVQHLQQV
 ... .|. ||  || ..| 
eavkelreqRpgavqtpsqy
Y_phosphatase Protein-tyrosine phosphatase 1-218 8e-57 187.7 Pfam-A 16-226 (235) alignment 
Range on Protein: 1-218
Range on HMM: 16-226/235.0
TRVVLpriHDDPE-SEYYNANWVRGADgNPKAYVAAMGPLPATLTHFWRTIWESNVSAIIMATGLIEKGKTKCERYWPAEVDGktAMHFGDIVVLSV-SE
||| |   ..... |.|.|||.|.| . ..|...|. |||. |. .||| .|. .|..|.| | | |||..||..||| | ..   ...||| |  . .|
trvkl...kgsegpsdYInAnyvkgyk.ekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeee..sltygdikvelkeke

A-KAKGYIFTQLKVVRHGES---RRIGHFWYNTWPDHGVPRDaerslyPDSVLGLLHTVHKWNsKFKDQPTLVHCSAGIGRTGTLIVIDHCRQLLKTQMR
  . |.|....|..  ..|.   |.. ...|..|||||||..      |.|.| |.. |.|.. . |..|..||||||.|||||....| . . |...  
kedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpes......pkslldlirkveksk.eaksgpvvVhCsaGvgRtgtfvaldilleqleaeee

ADPLAIIEAVRQDRPALVQHLQQV
 | | |.. .|. || .|| |.| 
vdvlqivkelRkqRpgmvqsleqY
Y_phosphatase Protein-tyrosine phosphatase 1-218 8e-57 187.7 In-house 16-226 (235) alignment 
Range on Protein: 1-218
Range on HMM: 16-226/235.0
TRVVLpriHDDPE-SEYYNANWVRGADgNPKAYVAAMGPLPATLTHFWRTIWESNVSAIIMATGLIEKGKTKCERYWPAEVDGktAMHFGDIVVLSV-SE
||| |   ..... |.|.|||.|.| . ..|...|. |||. |. .||| .|. .|..|.| | | |||..||..||| | ..   ...||| |  . .|
trvkl...kgsegpsdYInAnyvkgyk.ekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeee..sltygdikvelkeke

A-KAKGYIFTQLKVVRHGES---RRIGHFWYNTWPDHGVPRDaerslyPDSVLGLLHTVHKWNsKFKDQPTLVHCSAGIGRTGTLIVIDHCRQLLKTQMR
  . |.|....|..  ..|.   |.. ...|..|||||||..      |.|.| |.. |.|.. . |..|..||||||.|||||....| . . |...  
kedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpes......pkslldlirkveksk.eaksgpvvVhCsaGvgRtgtfvaldilleqleaeee

ADPLAIIEAVRQDRPALVQHLQQV
 | | |.. .|. || .|| |.| 
vdvlqivkelRkqRpgmvqsleqY
0040439 (Phosphotyrosine protein) phosphatases II 1-218 1.9e-56 186.8 In-house 26-235 (249) alignment 
Range on Protein: 1-218
Range on HMM: 26-235/249.0
TRVVLPRIHDDPESEYYNANWVRGADGNPKaYVAAMGPLPATLTHFWRTIWESNVSAIIMATGLIEKGKTKCERYWPAevdgKTAMHFGDIVVLSVSEAK
.||.|  . . . | |.||... | . ... ..|. |||| |. .||| .|| ....|.|.| | |.|. ||..|||     .. . .||..|  .|. .
srvklsilpglflsdyinAsyidgyyikrr.fiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywpl....ggsleygdftvtllsvev

AKGYIFTQLKVV--RHGESRRIGHFWYNTWPDHGVPrdaersLYPDSVLGLLHTVHKWNSKF-KDQPTLVHCSAGIGRTGTLIVIDHCRQLLKTQMRADP
 ..|. ..|...   .||||.. |..|  |||||||       .....| ... |.|....  |. |.|||||||.|||||.|... . ..|..  . |.
kddytvrtleltnlydgesrtvlhiqytdwpdhgvp......psfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaaylmleqlekelgvdl

LAIIEAVRQDRPALVQHLQQV
. ... .|. ||  || ..| 
eeavkllrsqRpgavqnpeqy
subfamily_PTPN6_pd Subfamily PTPN6 1-217 1.1e-55 183.8 In-house 69-285 (306) alignment 
Range on Protein: 1-217
Range on HMM: 69-285/306.0
TRVVLPrIHDDPESEYYNANWVRG-ADGNPKAYVAAMGPLPATLTHFWRTIWESNVSAIIMATGLIEKGKTKCERYWPAEVDGKTamhFGDIVVLSVSEA
|||.|   .. |.|.| ||| ... . |. |.|.|. | |..|.. ||| .|. |   |.|.|  .|.|| || ||||.| . ..   .|.| | .||| 
trvilk.epsvpgsdyinanyikkevkgsdksyiatqgclettvsdFWrmvwqensrvivmttkevErgkekCarYWPdeeekee...yGkisvtnvsek

KAKGYIFTQLKVV---RHGESRRIGHFWYNTWPDHGVPRDaerslyPDSVLGLLHTVHKWNSKFK---DQPTLVHCSAGIGRTGTLIVIDHCRQLLKTQ-
... ||. .|.|    ...|.|.. .. ...|||||||.|      |. || .|..|.. .....     |..||||||||||||.||||   .|.... 
sladYilRelsvskkkkkkeerevfqyhfksWPdhgvpkd......pgavLdfledvnrkqeeleeaeagpivvhCsaGiGRtGtfiviDillkliekkg

--MRADPLAIIEAVRQDRPALVQHLQQ
  .  |   ... ||. |  |||  ||
ldadidiqklvksvreqrsglvqteqq
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 1-217 3.8e-55 182.2 In-house 61-268 (318) alignment 
Range on Protein: 1-217
Range on HMM: 61-268/318.0
TRVVLPRIHDDPESEYYNANWVRGADgNPKAYVAAMGPLPATLTHFWRTIWESNVSAIIMATGLIEKGKTKCERYWPaevdGKTAMHFGDIVVLSVSEAK
||| |  ......|.| |||.. |   . |||.|| .||| |.. ||| .|| | . |.| | . |.||.|..||||    .| ....|..||   .| .
trvkLqmlegeegsDyinanyidGyr.rkkayiaaqaPlpetieDfWrmvWeqnsavivmltqeeergkakvhryWP....skgsrsygklvvelkeeve

AKGYIFTQLKVVRHG--ESRRIGHFWYNTWPDHGVPRDAerslypDSVLGLLHTVHKWNSKFKDQPTLVHCSAGIGRTGTLIVIDHCRQLLKTQMRADPL
 . |.  ..|| |..  ||| .  . | .|||.||| ..       |.| |. .|.|.. | . .|..||||||.||||. |..|   . .| .   | .
lsdyvlrefkvtrteeeesrqvrqyhytsWpdegvpesg......aslldlvrqvskaqqksgagpivvhCsaGvGrtGvfiavdillerikaealvDvf

AIIEAVRQDRPALVQHLQQ
 ... .|. |...||  .|
qtvkqlreqrnlmvqtedq
0042113 (Phosphotyrosine protein) phosphatases II 1-218 3.5e-54 179.2 In-house 24-232 (245) alignment 
Range on Protein: 1-218
Range on HMM: 24-232/245.0
TRVVLPRIHDDPESEYYNANWVRGADGNPKaYVAAMGPLPATLTHFWRTIWESNVSAIIMATGLIEKGKTKCERYWPAevdgKTAMHFGDIVVLSVSEAK
|||.|. .  |. | |.||..| | . .|| . |. |||| |. .||| .|| ....|.| | . |.|. ||..|||     .. . .||..|  .|| .
trvklspdggdldsdyinasyvdgyritpk.fiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywpl....gesltygdftvtllseeh

AKGYIFTQLKVV--RHGESRRIGHFWYNTWPDHGVPrdaersLYPDSVLGLLHTVHKWNSKFKDQPTLVHCSAGIGRTGTLIVIDHCRQLLKTQMRADPL
 ..|. ..|.|.  ...||| . |..|  |||||||       .....| .|. |.|. .. .. |.|||||||.|||||.|... . ..|.. .. .. 
lddytvrtlevtnlgddesrevihyhylpwpdhgvp......dllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylmleqlekelgvsle

AIIEAVRQDRPALVQHLQQV
 ... .|. ||  || ..| 
eavkelrsqRpgavqtpsqy
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 2-218 9.7e-53 174.1 In-house 63-268 (288) alignment 
Range on Protein: 2-218
Range on HMM: 63-268/288.0
RVVLPRIHDDPESEYYNANWVRGADGNpKAYVAAMGPLPATLTHFWRTIWESNVSAIIMATGLIEKGKTKCERYWPaevDGKTAMHFGDIVVLSVSEAKA
|| |   .. ....| ||... | ... |.|.|. |||..|. .||. ..| ..| |.| |.|.|.||||||.|||   |...  ..|.. |  |.. . 
rvklkkleeeagaDYinasyidgekkk.kkyiatqgPladtvndfWelvyenktstivmltelveggktkCeeYWP...dadkpknyGsvtvtlveskel

KGYIFTQLKVVRHGESRRIGHFWYNTWPDHGVPRDAErslypdSVLGLLHTVHKWNSKfKDQPTLVHCSAGIGRTGTLIVIDHCRQLLKTQMRADPLAII
. ..  .| ...... ..| .. | .|||||||....       .|.||..|.  |.. . .| .||||||.||||| |..|   . ....   | ....
edfvlrklllekkkteleitqyqylaWpdhgvPeska......pllellrqvkvanqa.dtgpiivhCsaGvGrtgtFialdalidaveeedyiDvagtv

EAVRQDRPALVQHLQQV
. .|. |. ||| |.| 
aklRkqRallvqtlkqY
subfamily_PTPN9_pd Subfamily PTPN9 1-217 1e-52 174.0 In-house 57-278 (297) alignment 
Range on Protein: 1-217
Range on HMM: 57-278/297.0
TRVVLPRIHDDPESEYYNANWVRGADgNPKAYVAAMGPLPATLTHFWRTIWESNVSAIIMATGLIEKGKTKCERYWPAEVDgkTAMHFGDIVVLSVSEAK
|||||.....|..|.| |||.| |   ..||..|. |||. | . ||| .||..|  |.|.| ..|.|. || .||| | .  ....|||. | .|.  .
trvvlakvdedeasdyinanfvdGyk.qkkafiatqGplkktvsdfWrmvWeqevlvivmttrvvergrlkcgqyWpleee..ssaefgdlsvsnvevee

AKGYIFTQLKVV--RHGESRRIGHFWYNTWPDHGVPRDAERSLYPDSV------LGLLHTVHKWNSKFKDQPTLVHCSAGIGRTGTLIVIDHCRQLLKTQ
 . | ...|..   ...|||.. || . .|||.|||..|.  |   ..      |   .  ..|. . .. | .||||||||||||.| .| | . |...
eedykvrvleiknvkteesrkvthfqflsWPdyGvPssaaslldvlekvrekqalavkelgdewkghpsgPPivvhcsaGiGrtGtfitldiclsrleev

MRADPLAIIEAVRQDRPALVQHLQQ
  .|    .. .|. |   .|  .|
gtvdvvetvkllrtqrafsiqtpeq
0045098 (Phosphotyrosine protein) phosphatases II 2-218 1.2e-52 174.4 In-house 49-261 (278) alignment 
Range on Protein: 2-218
Range on HMM: 49-261/278.0
RVVlprihddpesEYYNANWVRGAdgnPKAYVAAMGPLPATLTHFWRTIWESNVSAIIMATGLIEKGKTKCERYWPaEvdgKTAMHFGDIVVLSVSEAKA
||.          .| ||....|    ||...|. |||| |. .|||..|| ....|.|.|.|.|.|. ||..||| |   .  . .||..|  .||   
rVk..........dYINAsyidgy...pkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrekcaqywp.e...ggsltygdftvtllseevl

KGYIFTQLKVV------RHGESRRIGHFWYNTWPDHGVPRDAERslypDSVLGLLHTVHKWNS------------KFKDQPTLVHCSAGIGRTGTLIVID
. |. . |.|.       ..||| . |..| .||||||| .       .|.| ||  ......              .. |.|||||||.||||||....
ddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpil....ksflellefirealkllaslllsslllldsggpvlVHCsaGvgRtGtlvaay

HCRQLLktQMRADPLAIIEAVRQDRPA-LVQHLQQV
 ...||  . . |.| ... .|. ||   ||.|.| 
lmlell..eggvdlleavkelrsqRpglavqnleqy
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 2-217 1.3e-51 170.7 In-house 72-278 (298) alignment 
Range on Protein: 2-217
Range on HMM: 72-278/298.0
RVVLPRIHDDPESEYYNANWVRGADGNPkAYVAAMGPLPATLTHFWRTIWESNVSAIIMATGLIEKGKTKCERYWPAEvdgkTAMHFGDIVVLSVSEAKA
|||| ....| ||.| || .. ...|.. |..|. .||..|.. ||| ..| ....|.| | | |..|||...||| |     . ..|.| |   |. . 
RvvLekedadeesdYiNAsflhaykgrn.afiatqaPltetvedFWrmvteedigtiVmltnleeldktkyhkywPde....gketygeitvsllskeef

KGYIFTQLKVVRHG--ESRRIGHFWYNTWPDHGVPRDAErslypdSVLGLLHTVHKWNSKFKDQPTLVHCSAGIGRTGTLIVIDHCRQLLKTQMRADPLA
  .| ..||| ..   ..|.. .. . .|||.|||. |.      |||.||. |...... ...| .|.||||.||.|| |.||   . .|..   | . 
adlivrklkvskkkeekerevrqlhftsWpdkgvpenat......svldllrkvrasqqqagnkpvivqCsaGvgRsGtfiaidsvlervkkeqvvDvfq

IIEAVRQDRPALVQHLQQ
.....|..||..||  .|
vvkvlRkkrpgavqteeq
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 1-217 3.6e-51 169.1 In-house 63-271 (319) alignment 
Range on Protein: 1-217
Range on HMM: 63-271/319.0
TRVVLPRIHDDPESEYYNANWVRGADgNPKAYVAAMGPLPATLTHFWRTIWESNVSAIIMATGLIEKGKTKCERYWPAEvdgkTAMHFGDIVVLSVSEAK
|||||. ... ..|.| ||... | . . ....|...||  |.  ||| .|| ..| ..| |.| ||.| |...||| |    . ...| ..|   .| .
trvvlseldgvegsdyinasfidgyq.erekfiatqaPlentiedfWrmvWeeessivvmltklveklkvklkkywpee....nfeeyGrlivtleeeee

AKGYIFTQLKVVRH---GESRRIGHFWYNTWPDHGVPRDAErslypdSVLGLLHTVHKWNSKFKDQPTLVHCSAGIGRTGTLIVIDHCRQLLKTQMRADP
 ..||  .||. ..    |.|.. || |. ||||.||..|       |.| ||. ..|  .| ...|  ||||||.||||| ||.|   . .| .   | 
ledyiirklklnkkssevetRevkhfqyteWpdhdvPekat......slldllkrirksrektqsgPivvhCsaGvGRtGtfivldamlervkeegvlDv

LAIIEAVRQDRPALVQHLQQ
  ..  .|  |. .||. .|
fstvsrlRtqRnimvqrpeq
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 1-218 5.2e-51 168.3 In-house 24-231 (250) alignment 
Range on Protein: 1-218
Range on HMM: 24-231/250.0
TRVVLPRIHDDPESEYYNANWVRGADGNpKAYVAAMGPLPATLTHFWRTIWESNVSAIIMATGLIEKGKTkCERYWPAEVdgktAMHFGDIVVLSVSEAK
.|||| . . | ||.| || .. | |.. ||..|. |||.||. .||| ..| ....|.| | | |..|| ...|||.|.    | ..||. |   |. .
srvvLekekgdkesdyinasflhgyder.kafiatqgPlqatiedfWrmvleeksgtivmLtnLkesekt.yhqywPvek....aekyGdvtvsllskee

AKGYIFTQLKVVRHGESRR--IGHFWYNTWPDHGVPRDAErslypdSVLGLLHTVHKWNSKFKDQPTLVHCSAGIGRTGTLIVIDHCRQLLKTQMRADPL
   |. ..||. .. .. .  . .. . .||| |||. |.      .||.||. |.. . . ...| .|.||||.||.|. |.||   . ||..   |  
fadytkrklklskakkaderivrqlhfvvWPdkgvPevat......avLellkkvqasqqqagnaPvivqCsaGvgrsGafiaidavlerlkkekvvdvf

AIIEAVRQDRPALVQHLQQV
 .|...|.|||  |. |.| 
kvikvlrkdrphavesleqy
0037934 (Phosphotyrosine protein) phosphatases II 1-218 8.4e-51 168.2 In-house 25-231 (243) alignment 
Range on Protein: 1-218
Range on HMM: 25-231/243.0
TRVVLprihDDpeSEYYNANWVRGAdgnPKaYVAAMGPLPATLTH----FWRTIWESNVSAIIMATGLIEKGKTKCERYWPaevdGKTamHFGDIVVLSV
.||.|    ..  | |.|||....    |. . |  |||| |. .    ||| .|| ....|.| | |.|.|. ||..|||    |..  ..||..|  .
srvkl....eg..sdyinanliyvt...pr.liatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywp....gev..tygdftvtll

SEAKAKGYIFTQLKVVR---HGESRRIGHFWYNTWPDHGVPR-DAERSLYPDSVLGLLHTVHKWNSKFKDQPTLVHCSAGIGRTGTLIVIDHCRQLLktq
||   ..|. . |....    ...| . |..|  |||||||   .    . | |   .. .. ..   .. |.|||||||.|||||||... . .||   
seehlddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRtGtliaaylmllll...

mRADPLAIIEAVRQDRPA-LVQHLQQV
 . |.. ... .|. ||   || ..| 
.gvdleeavkllreqRpgkavqtpsqy
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 3-217 3e-50 166.1 In-house 63-271 (305) alignment 
Range on Protein: 3-217
Range on HMM: 63-271/305.0
VVLPRIHDDPESEYYNANWVRGADGNpKAYVAAMGPLPATLTHFWRTIWESNVSAIIMATGLIEKGKTKCERYWPAEVDGktAMHFGDIVVLSVSEAKAK
. |   .....|.| ||..| | ... |.|..| |||. |.. |||.|.|  || |.| |.|.| || ||..||| ..     ..||...|   ||..|.
iiltekeslddsdyinasyvdgykrk.kkyivaqgPlkntvadfWrliveekvstivmltklveggkdkCrqYWpeskte..kkefgefsvelksektas

GYIFTQLKVVR---HGESRRIGHFWYNTWPDHGVPRDAerslypDSVLGLLHTVHKWNSKFKDQPTLVHCSAGIGRTGTLIVIDHCRQLLKTQMRADPLA
.||  .||.       ||| . ..   .|||||||. |       |.| |.. |.|  .| |..| |||||||.||||. |..|   . ||.    |   
dyieRklkisiededkesrtvlqyqltdWPdhGvpqfa......tsllslikrvqkdqkkdkgvpllVhCsagvgRtGvfiavdialerlkkEevvdvfe

IIEAVRQDRPALVQHLQQ
.. ..|. |. .|| |.|
vlkqlRskrmkmvqtldq
subfamily_PTPN3_pd Subfamily PTPN3 11-218 7.8e-50 164.4 In-house 62-264 (280) alignment 
Range on Protein: 11-218
Range on HMM: 62-264/280.0
DPESEYYNANWVRG---ADGNPKAYVAAMGPLPATLTHFWRTIWESNVSAIIMATGLIEKGKTKCERYWPAEVDgktAMHFGDIVVLSVSEAKAKGYIFT
. |..| |||.|     . |  . |.|. |||. | |.||. .|| ..| |.| | |.|.|..|| .||| . |    ...|.. |   .|.. | |.. 
esetdyinanyvnmeipstglvnryiatqGPlaktatdfWqmvweqksslivmlttlverGrvkChqyWPeted...eleygefsvkcekedetksyvlr

QLKVVRHG--ESRRIGHFWYNTWPDHGVPRDAErslypdSVLGLLHTVHKWNSkFKDQPTLVHCSAGIGRTGTLIVIDHCRQLLKTQMRADPLAIIEAVR
.| . ..   |.|.| .. |  ||||||| |..      ..| ....|.|  |  |..|..||||||||||| ||... . .|. ..    ||.|.  .|
elvlkdketkeerkilqlqylaWpdhgvPddsa......dflefvervrklrs.gkeePvvvhCsaGigrtGvlilletalalieaaepvypldivrtmr

QDRPALVQHLQQV
. | .|||  .| 
dqramlvqtasqy
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 2-215 1.8e-49 163.2 In-house 59-262 (515) alignment 
Range on Protein: 2-215
Range on HMM: 59-262/515.0
RVVLPRIHDDPESEYYNANWVRGADgNPKAYVAAMGPLPATLTHFWRTIWESNVSAIIMATGLIEKGKTKCERYWPAEVdGkTAMHFGDIVVLSVSEAKA
|| |  |.|.|.|.|.||  ... | | |||.|. ||..|..  ||| ... ||..|.| | | |  | || .|||    |  ...|| | |  ||    
rvklevindnPhsdyfnasyipsfd.ndkayiasqgPnkasvddfWrlvlqenvttiamvtklkegdkikcgkyWPdkp.g.dsvkfGsikvelvsleac

KGYIFTQLKVVRHGESRRIGHFWYNTWPDHGVPRDaerslyPDSVLGLLHTVHKWNSKFKdQPTLVHCSAGIGRTGTLIVIDHCRQLLKTQMRADPLAII
 | |  .|.|..  .|| .  | .. |||.|||..        |.| |.. |   .....  | ..|||||.|||| .| || .    ||    | . ..
tggikrkltvlkgddsrtvtqfhfteWPdkGvpkh......tssllklikevkadhgqyt.hpliihcsaGvGrtGvvisidsvvahakttrmvdvfnfv

EAVRQDRPALVQHL
. .||.|| |||  
tnirqkrpylvqtq
subfamily_Ptp69D_pd Subfamily Ptp69D 1-218 3.3e-47 156.1 In-house 63-275 (307) alignment 
Range on Protein: 1-218
Range on HMM: 63-275/307.0
TRVVLPRIHDDPESEYYNANWVRGADgNPKAYVAAMGPLPATLTHFWRTIWESNVSAIIMATGLIEKGKTKCERYWPAEvdgkTAMHFGDIVVLSVSEAK
|||.|..|  . .|.| ||....| . . | ..|| .|. ||.  ||| |.| .|  |.| . | || . ||..||| |    . ...|||.|  ||| |
tRvkLkkingkedsdYinasfikgyk.ekkkfiaaqdPveatigDfWRmiaeqevtlivmlsnlteknrkkcakYWpie....devqygdilvklvseek

AKGYIFTQLKVVRHG-------ESRRIGHFWYNTWPDHGVPRDAErslypdSVLGLLHTVHKWNsKFKDQPTLVHCSAGIGRTGTLIVIDHCRQLLKTQM
.. ||  .|.| . .       .||..  . |..|.|  ||. |.      ..| |.. |.. . |..  | .|||||| ||.|... .|   | ||.  
hsdyiiReldvskkkeesgevedsrkvvqyhytgWkDskvPevar......gllklieqvrely.klnrsPivvhCsaGvgrsgifvaldsllqqlkaed

RADPLAIIEAVRQDRPALVQHLQQV
..|  ...  .|..|. ||| |.| 
kvdifetvkdLrsqRnllvqsleqY
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 2-215 1.4e-46 153.8 In-house 60-263 (315) alignment 
Range on Protein: 2-215
Range on HMM: 60-263/315.0
RVVLPRIHDDPESEYYNANWVRGADgNPKAYVAAMGPLPATLTHFWRTIWESNVSAIIMATGLIEKGKTKCERYWPAEvDGkTAMHFGDIVVLSVSEAKA
||.|  | |.|.|.|.||  ... | . |||.|. |||.|..  ||| .....|..|.| | . |  | || .||| . ..  ...|| | |  .|    
rvkleviddsPdsdyinasyiksvd.ddkayiasqgPlkasvddfwrmvlqekvttivmvtkkqegdkikcrqywPdr.ka.dsvefGsikvellslead

KGYIFTQLkVVRHG-ESRRIGHFWYNTWPDHGVPRDAErslypdSVLGLLHTVHKWnSKFKDQPTLVHCSAGIGRTGTLIVIDHCRQLLKTQMRADPLAI
 . .  .| |.|.. |||..  | .. |||.||....       |.| |.. |     . |. . |||||||.|||| .| ||.. . .| .   | . .
tdgvarkl.vtrkseesrtvtqfqftewPdkGvdkqts......sllklikevkad.ngkkefsllvhcsaGvGrtGvvisidevvaqikrtrsvdvfnf

IEAVRQDRPALVQHL
.. .|..|| |||  
vknlrakrpylvqte
subfamily_PTPRK_pd Subfamily PTPRK 2-218 9.6e-46 151.0 In-house 59-266 (314) alignment 
Range on Protein: 2-218
Range on HMM: 59-266/314.0
RVVLPRIHDDPESEYYNANWVRGADgNPKAYVAAMGPLPATLTHFWRTIWESNVSAIIMATGLIEKGKTKCERYWPAEvdgkTAMhFGDIVVLSVSEAKA
||.|  |..||.|.| ||... .   .|.|.... |||. |.. ||| ... | ..|.| | |.|.|. || .||| .    | . .||| |  |.    
rvflitidgdpssdyinaalidsyk.rpaafivtqgPlqetvkdfWrlvydencasivmltelvevgrvkClkyWPed....tev.ygdikvelvetell

KGYIFTQLKVVR----HGESRRIGHFWYNTWPDHGVPRDAErslypdSVLGLLHTVHKWNSKfKDQPTLVHCSAGIGRTGTLIVIDHCRQLLKTQMRADP
. ..   ..| .    . | | . .| . .||||.||  |.      ..|.|.. |.|.. . .. ...|||||| ||||| |.||   ......   | 
aelvvrifrveklargqeeirevrqfqflgWpdhdvPvsat......gllklvrrvkksqee.eaGrivvhCsaGaGrtGtfiaidivldmieregvvdv

LAIIEAVRQDRPALVQHLQQV
  .. ..|. .. .|.  .| 
fnavktlrsrkvnmveteeqy
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 1-218 1.2e-44 147.9 In-house 76-280 (319) alignment 
Range on Protein: 1-218
Range on HMM: 76-280/319.0
TRVVLPRIHDDPESEYYNANWVRGADgNPKAYVAAMGPLPATLTHFWRTIWESNVSAIIMATgliekgKTKCERYWPAEVDGKTamHFGDIVVLSVSEAK
..| | |.     |.| || .| |   ... |.|| |||. ||  ||| |||.|.|.|.. |      | || .||| ... |     ... | || |..
nvvklerliGeefsdyinasfvtGyq.rkdkyiaaqGPldntladfWrmiweyncstivllt......kdkcsqywplkivike..erfkvkvdsveeta

AkgYIFTQLKVVR---HGESRRIGHFWYNTWPDHGVPRdaerslYPDSVLGLLHTVHKWNSKFKD-QPTLVHCSAGIGRTGTLIVIDHCRQLLKTQMRAD
   |.  .... .   . . |.|  | .  |||.|||       ||  .. |.. |.. .|| .. .. .||||||.||||. ||.|   . .| . . |
e..yvvrdielsedgkekdirkitqfhflGwpdvGvpd......ypsdlmrlvkkvrhltskenhranivvhcsaGvGrtGvyivldvlldrmkeekqvd

PLAIIEAVRQDRPALVQHLQQV
   ... .||.|. |||.| | 
vynfvrdlrqqrntlvqdlvqy
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 2-218 1.3e-44 147.5 In-house 65-268 (315) alignment 
Range on Protein: 2-218
Range on HMM: 65-268/315.0
RVVLPRIHDDPESEYYNANWVRGADgNPKAYVAAMGPLPATLTHFWRTIWESNVSAIIMATGLIEKGKTKCERYWPAEvdgktAMHFGDIVVLSVSEAKA
|| || .  ||.|.| |||.. | .  .. |.|| ||..|..  ||| ..| ... |.| |.|.|. | |.|.||| .      . .| | |  .|| . 
rvqlpllendphsdyvnanfidGyn.kkrryiaaqgpnvasvkdfwrlvfeedigkivmltnlvegekrkaekywpdk.....kviyGkitvtrkseevn

KGYIFTQLKVVRHGESRRIGHFWYNTWPDHGVPRdaerslYPDSVLGLLHTVHKWNSKFKdQPTLVHCSAGIGRTGTLIVIDHCRQLLKTQMRADPLAII
. |    | ||   . | .  . | .||| |||.      |  ... |  ||.... .    . .||||||.|||||.| .|   . ....   |   .|
teytvrtlsvvfgdnirevvqlhytswpdmgvpk......ytiplmnlirtvkqhhtnsv.gaivvhcsaGvGrtGtfitldavldqaeaenaidvynfi

EAVRQDRPALVQHLQQV
. ||| |  .|| ..| 
tgvrqnrikmvqvaeqy
subfamily_PTPN13_pd Subfamily PTPN13 7-219 1.4e-44 147.4 In-house 53-259 (273) alignment 
Range on Protein: 7-219
Range on HMM: 53-259/273.0
RIHDDPESEYYNANWVRGA-DGNPKAYVAAMGPLPATLTHFWRTIWESNVSAIIMATGLIEKGKTKCERYWPAEVdGKTAMHFGDIVVLSVSEAKAKGYI
|.. . |. | ||....   . .   |.|. |||| | . ||. .|| ... |.| |   |||| ||.|||| .  .|. .  . . |  .   | .|. 
rvklgdeggyinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweqkaeviamvtlekekgkvkchrywPesk.nkklkvsnrlevellkvqkldgfv

FTQLKV--VRHGESRRIGHFWYNTWPDHGVPRDAerslypDSVLGLLHTVHKWNSkfKDQPTLVHCSAGIGRTGTLIVIDHCRQLLKTQMRADPLAIIEA
  .|.|  .. ||||.. |. . .|||||||. |      ...| ..  | . ..  .  | .|||||||||.||||.||   .|.. .   |   |.. 
vralavkdsesgesrevahlnfvkwPdhgvPssa......aellqfvaevrrlqt..dagPivvhcsaGiGrsGtlitidvvlglierdkefdvkeivrk

VRQDRPALVQHLQQVL
.|. | ..||  .| .
lreqrqgvvqtkdqyi
subfamily_PTPRA_pd Subfamily PTPRA 2-218 2e-44 146.8 In-house 74-284 (330) alignment 
Range on Protein: 2-218
Range on HMM: 74-284/330.0
RVVLPRIHDDPESEYYNANWVRGADGNpKAYVAAMGPLPATLTHFWRTIWESNVSAIIMATGLIEKGKTKCERYWPAEvdGktAMHFGDIVVLSVSEAKA
||.|. ..  .||.| || .. |     . ..|| ||.  |.  ||| ||| . ..|.| | | |. ..||..||| |  |  .. .|.| |    |  .
rvilsvkeGveesdyinasfidGykek.dkfiaaqGPkeetvedfwrmiweqksativmltelkerkeekcaqywPde..G..lvtyGnirvevedetvl

KGYIFTQLKVV------RHGESRRIGHFWYNTWPDHGVPRDaerslyPDSVLGLLHTVHKWNSKFKDqPTLVHCSAGIGRTGTLIVIDHCRQLLKTQMRA
. |   .. |       |. .|| .  | ...||| ||| .      |  .| ||. |.| | .  . |  ||||||.|||||.||.|   . .|.. . 
vdytvrkflvqqlpdatrekksrlvrqfhftswPdvGvPfe......piGmlkllkkvkklnqqsag.pivvhcsaGvGrtGtfivldavlervkaerkv

DPLAIIEAVRQDRPALVQHLQQV
|   ... .|. || .|| ..| 
dvfefvkrlrlqrpqmvqtdeqy
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 1-218 3.3e-44 146.5 In-house 40-244 (284) alignment 
Range on Protein: 1-218
Range on HMM: 40-244/284.0
TRVVLPRIHDDPESEYYNANWVRGADgNPKAYVAAMGPLPATLTHFWRTIWESNVSAIIMATgliekgKTKCERYWPAEVDGKTamHFGDIVVLSVSEAK
..| | |.     |.| || .. |   ... |.|. |||. ||  ||| |||.|.|.|.. |      | || .||| ... |   . ... | ||.|..
nvvklerliGeefsdyinasfitGyq.rkdkyiatqGPldntladfWrmiweyncstivllt......kdkcsqywplkivike..erfkvkvdsveese

AkgYIFTQLKVVRH---GESRRIGHFWYNTWPDHGVPRdaerslYPDSVLGLLHTVHKWNSKFKD-QPTLVHCSAGIGRTGTLIVIDHCRQLLKTQMRAD
   |.  .... ..    . |.|  | .  |||.|||       ||  .. |.. |.. .|| .. .. .||||||.||||. ||.|   . .| . . |
e..yvvrdielsedgkekdirkirqfhflgwpdvgvpd......ypsdlmrlvkkvrhltskenhranivvhcsagvgrtgvyivldvlldrmkeekqvd

PLAIIEAVRQDRPALVQHLQQV
   ... .||.|. |||.| | 
vynfvrdlrqqrntlvqdlvqy
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 2-216 3.7e-44 146.0 In-house 67-271 (297) alignment 
Range on Protein: 2-216
Range on HMM: 67-271/297.0
RVVLPRIHDDPESEYYNANWVRGADGnpkAYVAAMGPLPATLTHFWRTIWESNVSAIIMATGLIEKGKtKCERYWPAevdgKTAMHFGDIVVLSVSEAKA
|| |  . |||.|.| || .|.|       ...   | .||.  ||. ... .||.|.| . . |. | || |||.     |. . |||..|.  | .. 
RvkLaivnddpdsDyvnasfvkgnkh...rlittqmPmkatvadfWamvldeqvstivmlnddnerdk.kcaryWsd....kgvttfGdvsvvllsvser

KGYIFTQLKVVRHG--ESRRIGHFWYNTWPDHGVPRDAERSlypdSVLGLLHTVHKWNSKFKDQPTLVHCSAGIGRTGTLIVIDHCRQLLKTQMRADPLA
.|.|  .|.| .      | .  . .  |||. |.|  . |    |.| |.. |.|  |. .. | ||||.||.|||| |. || .    | .   | . 
eGfikrelevtkgkakarrvvkqyqfveWPdkaverkdsas....sllklisevrkdfsqnaegPllvhclaGvGrtgvlltidsvvaeakrekevdifg

IIEAVRQDRPALVQHLQ
... .||.|| |||  .
lvkklrqerpylvqtke
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 2-218 4.6e-43 142.1 In-house 24-230 (239) alignment 
Range on Protein: 2-218
Range on HMM: 24-230/239.0
RVVLPRIHDDPESEYYNANWVRGADGNPKAYVAAMGPLPATLTHFWRTIWESNVSAIIMATGLIEKGKTKCERYWPAEvdgkTAMHFGDIVVLSVSEAKA
|||| .. .|| |.| ||...|  ||.||||.|. | . ..   ||| .|.     |.| |||||  | || .|||      |. .    | |  .|  |
rvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpds....tskycnlrvtlrktevfa

KGYIFTQ-LKVVRHGESRRIGHFWYNTWPDHGVPRdaerslYPDSVLGLLHTVHKwNSKFKDQPTLVHCSAGIGRTGTLIVIDHCRQLLKTQMRADPLAI
   | |  .  | . | | . .. .  |||.|||.      |  .|||| . . | .|    .| ..|||||.||||...|||   .  | |   | .  
dyiirtfvmsqvgqteeryvyqyhftvwpdkgvpq......yatavlglrrkitk.dslpgarpwvihcsagvgrtgaflvidamlrqakkqktvdifny

IEAVRQDRPALVQHLQQV
..|.|.||| .||  .| 
vkairedrphmvqtseqy
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 2-218 4.6e-43 142.1 In-house 23-229 (239) alignment 
Range on Protein: 2-218
Range on HMM: 23-229/239.0
RVVLPRIHDDPESEYYNANWVRGADGNPKAYVAAMGPLPATLTHFWRTIWESNVSAIIMATGLIEKGKTKCERYWPAEvdgkTAMHFGDIVVLSVSEAKA
|||| .. .|| |.| ||...|  ||.||||.|. | . ..   ||| .|.     |.| |||||  | || .|||      |. .    | |  .|  |
rvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpds....tskycnlrvtlrktevfa

KGYIFTQ-LKVVRHGESRRIGHFWYNTWPDHGVPRdaerslYPDSVLGLLHTVHKwNSKFKDQPTLVHCSAGIGRTGTLIVIDHCRQLLKTQMRADPLAI
   | |  .  | . | | . .. .  |||.|||.      |  .|||| . . | .|    .| ..|||||.||||...|||   .  | |   | .  
dyiirtfvmsqvgqteeryvyqyhftvwpdkgvpq......yatavlglrrkitk.dslpgarpwvihcsagvgrtgaflvidamlrqakkqktvdifny

IEAVRQDRPALVQHLQQV
..|.|.||| .||  .| 
vkairedrphmvqtseqy
subfamily_PTPN1_pd Subfamily PTPN1 12-218 2.9e-42 139.4 In-house 54-260 (290) alignment 
Range on Protein: 12-218
Range on HMM: 54-260/290.0
PESEYYNANWVRgADGNPKAYVAAMGPLPATLTHFWRTIWESNVSAIIMATGLIEKGKTKCERYWPAEVDgKTAMHFG--DIVVLSVSEAKAKGYIFTQL
 . .| ||. |  ..   . |. . |||| | .|||. .|| .  |..|   ..||...|| .||| . . . .. .    . |  .|| . . |.  .|
adndyinaslve.leeakrsyiltqGPlpntvdhfWqmvWeqkskavvmlnkvvekeqikcaqywPqgee.ekellledtklkvkliseerksyytvrll

KVV--RHGESRRIGHFWYNTWPDHGVPRDaerslyPDSVLGLLHTVHKWNSKFKDQ-PTLVHCSAGIGRTGTLIVIDHCRQLLKTQMRADPLAIIE---A
..   .  |.| | || | |||| |||.       | . | .|. | .  |  .|. |...||||||||.||....| |  |.. .  .. . | .   .
elenlktqetreilhfhyttwpdfgvpes......paaflkflfkvresGslssdvGpavihcsaGiGrsGtfclvdtclvliekkddlssvdikkvlle

VRQDRPALVQHLQQV
.|. |  |.|  .|.
lrkyrlGliqtadql
subfamily_PTPN14_pd Subfamily PTPN14 2-217 3.9e-42 139.3 In-house 65-284 (300) alignment 
Range on Protein: 2-217
Range on HMM: 65-284/300.0
RVVLPRIHDDpESEYYNANWVRGA-DGNPKAYVAAMGPLPATLTHFWRTIWESNVSAIIMATGLIEKGKTKCERYWPAEVDGKTAMHFGDIVVLSVSEAK
|| |   ... ...| ||  .. .  |. . |..| |||. |.. ||. .||..|. |.| |  .|.||.|. .|.| . . |  ..||   | .    .
rvelsptken.stgyinassikvsvggkersyivaqgPleltvqdfWqmvWeqgvqlivmlteeeedgkeksfkyfPkleskkktvefgkfkvttkfsed

AKGYIFTQLKV--VRHGESRRIGHFWYNTWPDHGVPRDAERSL-YPDSVLGLLHTVHKWN-SKFKDQPTLVHCSAGIGRTGTLIVIDHCRQLLKTQMRAD
.. .| |.||.  .  .| | . |. |. |||||||.| .  | | . |  . . ... . || .. | |||||||.|||| ||. |   . |... . |
sdsvittglklkhlpskeertvwhlqytDWpdhgvPeDvkgflsyLeevqsvrrktnseveskeskPPvlvhCsaGvGrtGvlilsdlliatlehneeid

PLAIIEAVRQDRPALVQHLQQ
   ... .|. |  ||| | |
ikkvlarLreqrmllvqtlaq
0051429 (Phosphotyrosine protein) phosphatases II 14-218 1.2e-40 135.3 In-house 4-214 (272) alignment 
Range on Protein: 14-218
Range on HMM: 4-214/272.0
SEYYNANWVRGAdGN---PKAYVAAMGPLPATLTHFWRTiWESNVSAIIMATGLIEKGKTKCERYWP--------AEVDGKTAMHFGDIVVLSVSEAKAK
| |.||..| |  |.   |... .. ||||.|  .|||  .| ....|.. ... |.|. ||.||||         . |. . . .|...|  .||    
sgyiNardvggy.grvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseelll

GYIFTQLKVV---RHGESRRIGHFWYNTWPDHGVPRDAerslypdsVLGLLHTVHKwnskfkDQPTLVHCSAGIGRTGTLIVIDHCRQLLKTQMRAD---
 || . | ..     ||.|.. |..|  |||||||..|        .| ||. ...      ..| |||||||..||||....... . .  .  .|   
dyilrellltlllsagearevmhlhytdwpdhgvpqea........llellellld......ggpvlvHCsaGkdRTGtvvallllllgvsletivddYl

-----PLAIIEAVRQDRPALVQHLQQV
     .....| .|. ||. ||. .|.
ltnlyleeaveelraqrpgavqteeqy
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 2-218 2.2e-40 133.8 In-house 64-277 (325) alignment 
Range on Protein: 2-218
Range on HMM: 64-277/325.0
RVVLPRIHDDPESEYYNANWVRGADgNPKAYVAAMGPLPATLTHFWRTI--WEsnvSAIIMATGLIEKGKTKCERYWPAEVdGKtAMHFGDIVVLSVSEA
||||   .|||.|.|.||...|    . . ..||  ||.||.  .|| .  |.   ..... .  ...|| .|  ||| |. || . .|| . |  ..  
rvvletkkddpssdyinasylrddk.kkdvflaaqaPltatindlWrlvldWr...csvvvvlneldlgkdrcavywpkem.gk.sktfGglevklrtie

KAKGYIFTQL--KVVRHGESRRIGHFWYNTWPDHGVPRdaerslYPDSVLGLLHTVHKWNSKFKD-----QPTLVHCSAGIGRTGTLIVIDHCRQLLKTQ
.   |.  .|  | |..||.| .  | . .|.| ||..      .| ... .|..|.. . . .       | |||||||.||||..| .    . . ..
eisdyvhrvldvkqvkkGetrsvkqfqlqswddmGvqk......rpatlisilqlvkavservtantkastpilvhcsaGvGrtGvfislysalakviee

MRADPLAIIEAVRQDRPALVQHLQQV
 | | .  .. .|.|||..|.   | 
srvdifgfvkklrkdrpsmvetvdqy
subfamily_PTPRG_pd Subfamily PTPRG 2-217 9.2e-40 131.4 In-house 63-275 (563) alignment 
Range on Protein: 2-217
Range on HMM: 63-275/563.0
RVVLPRIHDDPES-EYYNANWVRGADgNPKAYVAAMGPLPATLTHFWRTIWESNVSAIIMATGLIEKGKTKCERYWPAevdgKTAMHFGDIVVLSVSEAK
|| |  . .  .. .| |||.. |     ||..|. |||. |.  ||| ||| ||. |.| | | |.|. ||..|||.     .....| . |  ..| .
RvklsplpgkkkklDYinAnyidGyq.kskafiatqgplkdtfddFWrmiWeqnvaiivmitnlvergrrkcdvYWPk....desetygalqvtlieeev

AKGYIFTQLKVVR----HGE----SRRIGHFWYNTWPDHGVPRdaerslYPDSVlglLHTVHKWNSKFKD--QPTLVHCSAGIGRTGTLIVIDHCRQLLK
   |   .|..      ...     ... .. | .|||||||       ..  |   |  |.| .   |.   |..||||||.|||||.||.|   . ..
lalytvrtlviknlklkkkkqcdteklvrqyhytkWPdhgvPe......hslpv...LifvkkssaankaeaGPivvHcsaGvgrtGtyivldtllkqiq

TQMRADPLAIIEAVRQDRPALVQHLQQ
..   . . ..  .|  |. |||   |
qenavnvfgflkhiraqRnflvqteEq
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 11-218 4.6e-39 129.0 In-house 56-284 (297) alignment 
Range on Protein: 11-218
Range on HMM: 56-284/297.0
DPESEYYNANWVRGADG-NPKAYVAAMGPLPATLTHFWRTIWESNVSAIIMATGLIEKGKTKCERYWPAEVDGKtaMHFGDIVVLSVSEAKA--KGYIFT
 .|..| ||..|   |  ..  |. | ||| ||.  ||. ..| .| .|.| . | | |. ||  |||  |...  .. ||.||  .|.     .  |.|
iterdyinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmvaklqedGrdkcapywpsvvqer..lkagdvvveflsstsdefdrvilt

QLKVVRHGESRRIGHFWYNTWPDHGVP---RDAERS--------LYPDSVLGLLH--------TVHKWNS-KFKDQPTLVHCSAGIGRTGTLIVIDHCRQ
.|...   ||| . |  . .|||||||    | .|         .    .|.|..         .   .. . .. ..|||||||.||.| ..  |   .
elqliyrsesrvvrhvqflswpdhGvpsdledlvrfqaqvcscciavpmmlalvemftamvflqleslraemprnayllvhcsaGvGrsGvvvlsdvila

LLKTQMRADPLAIIEAVRQDRPALVQHLQQV
 |. .   |  ||.. .|. |. ||| |.| 
klrkkripdvaailsilreqrarlvqtleqf
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 2-218 4.2e-38 125.9 In-house 62-272 (290) alignment 
Range on Protein: 2-218
Range on HMM: 62-272/290.0
RVVLPRI--HDDPESEYYNANWVRGADgNPKAYVAAMGPLPATLTHFWRTIWESNVSAIIMATGLIEKGKTKCERYWPAEvdgKTAMhFGDIVVLSVSEA
|..| .|  | | . || || .. |   . |.|.|. ||.. || .||. ||. .|..|.| |  ||.||.||  |||..   .|.. .| . .  ..| 
ritLrpisghkDCtneyinAcyikgyk.ekkqyiatqgpvsntlvdFWkliwqekvtiivmltniieegkvkCqqYWpds...dtka.ygefsikllnee

KAKGYIFTQLKVVRHGE---SRRIGHFWYNTWPDHG-VPRdaerslyPDSVLGLLHTVHKWNSKFKDQPTLVHCSAGIGRTGTLIVIDHCRQLLKTQMRA
. ..|| ..|.|  . .   .. . ..   .|...| |.        | ..| ... . | . |  ... .||||...||........   .  ||.   
tlneyierklevknknsagakqsvtqyqitnwdstgkvtn.......pqtillvieemyktqrkrgntsivvHCSdtvgrsavfcaaattinkcktegvi

DPLAIIEAVRQDRPALVQHLQQV
| .....  |. .| .||  ||.
dvfqvlksqRiqkpgsvqtvqqy
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 12-218 6.5e-38 125.3 In-house 27-228 (237) alignment 
Range on Protein: 12-218
Range on HMM: 27-228/237.0
PESEYYNANWVRGADGNPKAYVAAMGPLPATLTHFWRTIWESNVSAIIMATGLIEKGKTKCERYWPAEVDGKTamhFGDIVVLSVSEAKAKGYIFTQLKV
 .|.| ||....| || || |.|| ||| ..   ||. .|. . | |.| |||||. . || .|||   . ..   .| . |    . .   |    | .
sgsdyinatylkgfdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywpstdqpaa...ygvltvslkkkeefsdytvrslll

VRHG---ESRRIGHFWYNTWPDHGVPRDAErslypdSVLGLLHTVHKW-NSKFKDQPTLVHCSAGIGRTGTLIVIDHCRQLLKTQMRADPLAIIEAVRQD
....   | | |  . . .|||.|||. .       ..| . . . .  .   .  | ..|||||.|||| ..|||   .  | .   |    . .. .|
skrltlkevrlihqyqftswpdrgvpqqta......allrfrkniinrsphvsesgpwiihcsagvgrtgiflvidamlrqakekkvvdiynyvysieed

RPALVQHLQQV
|| ..|  .| 
rpyiiqtkdqy
subfamily_PTPN23_pd Subfamily PTPN23 1-217 2.4e-36 120.0 In-house 58-268 (288) alignment 
Range on Protein: 1-217
Range on HMM: 58-268/288.0
TRVVLPRIHDDpeseYYNANWVRGADGNPKAYVAAMGPLPATLTHFWRTIWESNVSAIIMATGLIEKGKTKCERYWPAEVDgkTAMHFGDIVVLSVSEAK
.||.|   .||    | || .|..       ..|. .||. ||  ||. ..|  .| |.| .   |.||.|..||||.. .   ...|||. |   |. .
nRvklrgskDD....YinAsfvkdlspgcPdfiatqaPlqstlnDFWlmvyeqkssviVmllskeelgkpkvdrYwPedkg..etvkfgdlsvtlksvre

AKGYIFTQLKVVRHGE--SRRIGHFWYNTWPDHGVPRDAERSLypdSVLGLLHTVHKWNSKFKDQPTLVHCSAGIGRTGTLIVI-DHCRQLLKTQMRADP
.. ..  .||.  ...   . . |  ...||..|||   |  |    .|.  .. .. . .  ..| .||||||.||||.. ..    |.| | .  .| 
tethvervlkletldadavksvshlqltsWpelGvPasPetll...qfldevesayeavqrksktPlvvhCsaGvgRtgvfalvyaavrelekgnglldi

LAIIEAVRQDRPALVQHLQQ
. ... .|..|   ||. .|
iqvvsrlreqRrfmvqekeq
subfamily_PTPRN_pd Subfamily PTPRN 2-217 3.5e-36 119.4 In-house 72-280 (297) alignment 
Range on Protein: 2-217
Range on HMM: 72-280/297.0
RVVLPRIHDDPESEYYNANWVRGADGNPKAYVAAMGPLPATLTHFWRTIWESNVSAIIMATGLIEKGKTKCERYWPAEvdGKTAMHFGDIVVLSvSEAKA
|| | .  .. .|.| ||  .   |    ||.|. |||..|...||...||. |  |.. | | |.| ..|.|||| |  |.   |. .. ..|     .
rvklkeeasaeksdyinasaildhdprapayiatqgplastvadfwqmvweqGvvvivnltrleeegvkqckrywpde..Gsevyhiyevhlvs.ehiwc

KGYIFT--QLKVVRHGESRRIGHFWYNTWPDHGVPRDAErslypdSVLGLLHTVHKWNSKfKDQPTLVHCSAGIGRTGTLIVIDH-CRQLLKTQMRADPL
. |.     || ..  |.| .  | . .||..|||  |       |.| .   | |     .  | .||||.| ||||. |.||  . .|||   . |  
ddylvrsfylknlqtsetrtvtqfhflswpeegvPasak......sllefrrkvnksyrG.rscpivvhcsdGaGrtGvyilidlvlnrllkGvkeidia

AIIEAVRQDRPALVQHLQQ
| .| .|..|| ||.  .|
atlehlrdqrpglvktkdq
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 1-217 9.3e-36 117.9 In-house 71-271 (290) alignment 
Range on Protein: 1-217
Range on HMM: 71-271/290.0
TRVVLpriHDDPESEYYNANWVRGADgnpKAYVAAMGPLPATLTHFWRTIWESNVSAIIMATGLIEKGKTKCERYWPaEVDGKtAMHFGDIVVLSVSEAK
|||.|   .|  . .|  ||.|.| .     .. . |.| .|   .|| . . .|.||.|   |||.||.|||.|.| | .|. .. ||.| ||   | .
trvil...kdGydGdyvhanyvkGlk...amfiltqGalkdtvidiwrmvlqekvaaivmlceliedGkakceqyyp.ekeGe.vltfGeitvlcseedd

AKGYIFTQLKVV---RHGESRRIGHFWYNTWPDHGVPRdaerslypdSVLGLLHTVHKWNSkfKDQPTLVHCSAGIGRTGTLIVIDHCRQLLKTQMRADP
    |  ..  |     | . .. |.   .|||. |.          | | || |..         |  ||||||||||||.. |. . |.|      |.
kdaniikktlsvrdkdsGkehklkhlkikswpdksval.........stlallrtlrilrk..asGpvvvhcsaGiGrtGtfvaievglqilldGkeldl

LAIIEAVRQDRPALVQHLQQ
| .. |.|. | . ||   |
ldlvralrnsrlnsvqvdiq
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 1-219 2.2e-35 117.0 In-house 63-269 (439) alignment 
Range on Protein: 1-219
Range on HMM: 63-269/439.0
TRVVLPRIHDDPESEYYNANWVRGADgNPKAYVAAMGPLPATLTHFWRTIWESNVSAIIMATGLIEKGKtkcerYWPAEVDgktaMHFGDIVVLSVSEAK
|||.|  |   | | |.|||...|   ..| |.|. ||   |  .||| ..| ... |.| | |.|  |     |||.. .    . .|||.|    . .
trvtlqeipgvphshyinanyikGyy.ddklyiatqgpkkettddfwrlviekktvtivmltnlvesyk.....ywpsdae....vcygdiavrvdrnie

AKGYIFTQLKVVRHG----ESRRIGHFWYNTWPDHGVPRDAErslypdSVLGLLHTVHKWNSKFKDQPTLVHCSAGIGRTGTLIVIDHCRQLLKTQMRAD
   |.   .||. .       | . .| | .|||. || .|        || .|...   | | .  | .||||||.|||||.| .| . . ||.. . |
lpnyvirgfkvfnerdttekertvlqfhyiawpdknvpaqas......hvldflrainsandkeeygpvvvhcsagvGrtGtiialdialeqlklenkvd

PLAIIEAVRQDRPALVQHLQQVL
   |.. .|..|  .||.| | .
ikgivkvlrkqrkqmvqalcqyv
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 11-217 6.5e-35 115.3 In-house 62-265 (287) alignment 
Range on Protein: 11-217
Range on HMM: 62-265/287.0
DPESEYYNANWVRGADGNpKAYVAAMGPLPATLTHFWRTIWESNVSAIIMATGLIEKGKTKCERYWPAEvdgKTAMHFGD--IVVLSVSEAKAKgYIFTQ
.  |.| |||.| .   . .|..|| ||..||.  ||| ..| .....|. |  .|... || .|||     .  |  |   .|.|. .  . . |    
elGsdyinanyvasytdd.eafiaaqgPiaatvrdfwravletrsasvitmtreveearlkcykywPer...evPmrvGGysvvlldydikePe.ygvra

LKVVRHG--ESRRIGHFWYNTWPDHGVPRDAERslYPDSVLGLLHTVHKWNSKFKDQPTLVHCSAGIGRTGTLIVIDHCRQLLKTQMRADPLAIIEAVRQ
|...     |.| .  . . .|||....  |    .   ||   . .    .  .  | .||...||||.|.|. .  . . |.   | |. |..  .|.
lrlidletrearvvkqldllswPdkvlaPtavg..lirfvldvkqhielardasevGPlvvhddvGiGrsGillatlvlvsrledlGrvdvaavvirlre

DRPALVQHLQQ
 | ||||   |
yraalvqavvq
0041856 (Phosphotyrosine protein) phosphatases II 12-218 2.4e-34 113.9 In-house 17-160 (182) alignment 
Range on Protein: 12-218
Range on HMM: 17-160/182.0
PESEYYNANWVRGADGNPKaYVAAMGPLPATLTHFWRTIWESNVSAIIMATgliekgktkCERYWPaevdgktamhfgdivvlsvseakakgyiftqlkv
. . | |||...|.  . . ..|. |||. |. .|.|...| ....|...|         .|.|||                                  
rdldyInanlylgslpatr.fiatqgpllstvadflrmlkelgittivnlt.........eelywp..................................

vrHGESRRIGHFWYNTWPDHGVPRdaerslyPDSVLGLLHTVHKwnskfKDQPTLVHCSAGIGRTGTLIVIDHCRQLlktqmRADPLAIIEAVRQDRPAL
    . | . ...|  |||||||        .|..| ....|..     .. |.|||||||.||||||.... ...|     . ..  ... ||. ||  
..ellerlgiqylylpwpDhgvpd.......ldelldfieevle.....eggpvlVHCsaGvgRtgtlvaaylmkkl.....gvsleeavklvrsrRpgm

VQHLQQV
|....| 
vitpnqy
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 2-218 3.7e-34 113.0 In-house 63-267 (287) alignment 
Range on Protein: 2-218
Range on HMM: 63-267/287.0
RVVLPrihdDPESEYYNANWVRGADgNPKAYVAAMGPLPATLTHFWRTIWESNVSAIIMATGLIEKGKTKCERYWPAEvdgKTaMHFGDIVVLSVSEAKA
||.|     . . .| || .. |   . ||...| .|.  |.  ||. |.. ||.||.| . . |. . .| .||| |   |. . .|.  .  ..| . 
rvllk....gehpdyinavfidgyk.ekkafiiaesPmfntarnfWkliddrnvtaivmlcqekendeevcyqyWpee...ks.vvlGeyniellneevn

KGYIFTQLKVVRHG---ESRRIGHFWYNTWPDHG-VPRdaerslyPDSVLGLLHTVHKWNSKFKDQPTLVHCSAGIGRTGTLIVIDHCRQLLKTQMRADP
.|||  .|.| ...   . ...  . . .|...| |..       | ..| ...   | . |  . . .||||...||..... ..   .  ||.   | 
agyierklevknknkagdkqqvkqyqitnWdstgkvte.......pqtillvieemyktqrkrgntsivvhCsdtvGrsamfcaaattinkckteGviDv

LAIIEAVRQDRPALVQHLQQV
. ...  |. .|  ||  .| 
fqvlksqriqkpgsvqtveqy
subfamily_CG42327_pd Subfamily CG42327 1-137 7.2e-34 111.9 In-house 43-180 (319) alignment 
Range on Protein: 1-137
Range on HMM: 43-180/319.0
TRVVLPRIHDDPESEYYNANWVRGADGNPKAYVAAMGPLPATLTHFWRTIWESNVSAIIMATGLIEKGKTKCERYWPAEVDGKTAMHFGDIVV-LSVSEA
|||||.|| ||...|| .|..||| |  |  |.||  .|  . . ||||.|| .   |. .| | |.|  .| .|.|..  ..    .||| | |   |.
trvvlqrigdddkdeyldasyvrGyddapnsyiaaqvsledsssdfwrtvweqqsrvivqltdlselGikvcaeylPtketldntslyGdilvtlkgrev

KAKGYIFTQ-LKVVRHGESRRIGHFWYnTWPDHGVPRDA
| . .| |  || | . ||| . |.||  |.. .|| . 
kdryaistlllkrvdkeesrelthywy.kwleaevPaee
0043147 (Phosphotyrosine protein) phosphatases II 11-219 9.6e-34 111.9 In-house 2-151 (172) alignment 
Range on Protein: 11-219
Range on HMM: 2-151/172.0
DPESEYYNANWVRGADgNPKAYVAAMGPLPATLTHFWRTIWESNVSAIIMATGLiekgktkcerywpaevdgktamhfgdivvlsvseakakgyiftqlK
|. | |.||... .    |. ..|  |||. || .||| ..| ....|...|.|                                              
degsdyinasyldlyy.ipdrfiatqgplrntladfwrmlkelgithivnltel.............................................l

VVRHGESRRIGHFWYNTWPDHGVPrDaerslyPDSVLGLLHTVHKWNSKFKDQPTLVHCSAGIGRTGTLIVIDHCRqllktqMRADPLAIIEAVRQDRPA
. . ...| . ...|  ||||||| .      .. .| .|. ....  . .. |.|||||||.||||||.... ..      .. ... ... ||. || 
ydpellerlgiqylylpwpDhgvp.l......lellleflefidellalspggpvlVHCsaGvgRtgtlvaaylml......lglsleeavalvrekRpg

LVQHLQQVL
 ||. .|  
avqnpsqyr
0046846 (Phosphotyrosine protein) phosphatases II 6-218 2.6e-33 110.6 In-house 4-162 (176) alignment 
Range on Protein: 6-218
Range on HMM: 4-162/176.0
PRIHDDPESEYYNANWVRGAdgnpkAYVAAMGPLPATLTHFWRTIWESNVSAIIMATGLIEKGKTKCERYWPAEVDGKTamhfgdivvlsvseakakgyi
 ....|. . | |||.. |.     ...|  |||| || .|.. ..| ...|... | ..|.|. || .||| . . .                      
rllgldldldyinanlilgs.....rpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgi.....................

ftqlkvvrhgesrrigHFWYNTWPDHGVPRDaerslypDSVLGLLHTVHKWNSKfkDQPTLVHCSAGIGRTGTLIVIDhcrqLLKTQMRADPLAIIEAVR
                ....  ||||||| .       . .| ||  .... ..  ..|.||||||||||||||....    ||....  ... ... ||
................qylhlpwpDhgvpdl.......elllellefirealke..ggpvlVHCsaGigRtgtlvaay....llelekglsveealalvr

QDRP-ALVQHLQQV
. ||   ||. .|.
eqRplgavqtpeQy
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 10-219 4.6e-33 109.5 In-house 63-267 (307) alignment 
Range on Protein: 10-219
Range on HMM: 63-267/307.0
DDPESEYYNANWVrGADGNPKAYVAAMGPLPATLTHFWRTIWESNVSAIIMATGLIEKGKTKCERYWPAEvDGKTAMHFGDIVVLSVSEAKAK------G
|   |.|  ||.. |   .|| ...| ||| .|  .||  . . .| ..||   .|| .| |||.|||.| .|.. ..      .||..  ||       
dglasdyihanyl.giaikpkkficaqgplentqysfwamaiqekvesvimlckvielakikceqywple.egqklvfgeapntisvanlgakklapded

Y-IFTQLKVVRHGESRRIGHFWYNTWPDHGVPRDAersLypdSVLGLLHTVhkwnsKFKDQPTLVHCSAGIGRTGTLIVIDHCRQ-LLKTQMRADPLAII
.   |.|||.  ..|| | |. .. |||.|||.     |   . . ||..|     ...  | .||||||.||.||.. |   .. ... .   |   ..
linvttlkvdwaqksrtiqhlqwenwpdrgvpqin...l...tainlleav.....rydtnpvvvhcsaGvGrsGtivaislvqdkmiaGinckdmkklv

EAVRQDRPALVQHLQQVL
| .|..|.  .|   | |
eelrsqrhyaiqteaqyl
0036282 (Phosphotyrosine protein) phosphatases II 14-218 2.8e-32 107.2 In-house 2-159 (174) alignment 
Range on Protein: 14-218
Range on HMM: 2-159/174.0
SEYYNANWVRGADGNPkAYVAAMGPLPatlthFWRTIWESNVSAIIMATGLIEKGKTKCERYWPAevdgktamhfgdivvlsvseakakgyiftqlkvVR
| |.||... .   .|  ..|  |||.     ||. ..| ......| . ..|.|..|| .|||                                   |
sdyinaspldlsyitp.rliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe.................................lr

HGESRRIGHFWYNTWPDHGVPrdaersLYPDsVLGLLHTVHKWNSKFKDQPTLVHCSAGIGRTGTLIVIDHCRQLLKtqmrADPLAIIEAVRQDR---PA
. ..| . ...|  |||||||        .  .| ..  |... |. .. |.|||||||.||||||.... . ..|.     ..  ... ||. |   | 
edlerlgiqylylpwpDhgvp......dlsi.llefvkfveealsedpggpvlVHCsaGvgRtGtlvaaylmlrgll....eslvdaldlvrelRlqrpg

LVQHLQQV
 ||. .| 
mvqtpsQy
0049260 (Phosphotyrosine protein) phosphatases II 29-218 7.4e-32 105.5 In-house 8-139 (152) alignment 
Range on Protein: 29-218
Range on HMM: 8-139/152.0
PKAYVAAMGPLPATLTHFWRTIWESNVSAIIMATGLIEKGKTKCERYWpaevdgktamhfgdivvlsvseakakgyiftqlkvvrhgesrrigHFWYNTW
|....|. ||.| || .||| ..| ....|.| | | |.|| |||.|.                                             .. .  |
pfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi.............................................qylhlpw

PDHGVPRDAERSLYpdsvlglLHTVHKWNSKFKDQPTLVHCSAGIGRTGTLIVIDHCRqllktqMRADPLAIIEAVRQDRPALVQHLQQV
|||||| ...  |        |. ....  . |. |.|||||||.||||||.... ..      .. ... ... ||. ||  |.. .| 
pDhgvpdlsqlllf.......lllfieklaldkggpvlVHCsaGvgRtgtlvaaylml......lgvsleeavalvrekRpgavpnpgql
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 10-218 1e-31 104.8 In-house 66-282 (301) alignment 
Range on Protein: 10-218
Range on HMM: 66-282/301.0
DDPESEYYNANWVRGADgNPKAYVAAMGPLPATLTHFWRTIWESNVSAIIMATGLIEKGKTKCERYWPAEVdgKTAMHFGDIVVLSV-------------
|  . || ||... |   . |...|| ||.  ||. ||| ||.  ...|.| |.| |. |.|||.|||     ..  .|| . |. |             
dlcqreyinasyidgys.ekkkfiaaqgpmkktlvdfWrliwqekpvsivmvtnlkegtkskceqywpnse..aeseefgpftvtlvneqvyPdfvirql

----SEAKAKGYIFTQLKVVRHGESRRIGHFWYNTWPDHGVPRDaerslyPDSVLGLLHTVHKWNSKFKDQPTLVHCSAGIGRTGTLIVIDHCRQLLKTQ
     ..  .|||  ..|| .. .|. .  .    ||..|| |.      |  ||  .. | . . |    | .||||....|.|. . ..      | .
nvkiqdgsnngyierkfkvksdksswdvlqlqvtdWpqdGvvre......prtvLqviddvihrqqkigggpvvVHCSdtVsrsGvYcsvsiglEQckae

MRADPLAIIEAVRQDRPALVQHLQQV
   |   ...|||. .|  |. |.| 
gVVdvfqvtkavrrskpgaVtTLeqy
subfamily_ptpA1_pd Subfamily ptpA1 1-181 6.3e-31 102.5 In-house 62-248 (418) alignment 
Range on Protein: 1-181
Range on HMM: 62-248/418.0
TRVVLPRIHDDPESEYYNANWVRGAdgNPKAYVAAMGPLPATLTHFWRTIWESNVSAIIMATGLIEKGKTKCERYWPAEVDGKTAMHFGD-------I--
||| | .|.|   |.| |||.. ||   || .... |||| |.. ||| .||  .  |.| .   |. . ||.|||| .. |.    .|.          
trvqlkkiqdkegsdyinanyidga..ypkqfictqgplpntiadfwrmvwenrcriivmlsresencrikcdrywpeqiggeqfsiygngnevfgtysv

VVLSVSEAKAKGYIFTQLKVVRHGESRRIGHFWYNTWPDHGVPRDAErslypdSVLGLLHTVHK-----WNSKFKDQPTLVHCSAGIGRTGTLIV
 .. | .   .  |  ....   ||.| | .. |. |||| .|  ..       .  |||.. .       |  .. | .||||||.|||||.  
elveviqdpereiitrnirltfegetrditqyqyegwpdhnipdhtq......pfrqllhsitnrqnqiipssdrnvpiivhcsagvgrtgtfct
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 8-229 2.2e-30 100.5 In-house 50-270 (283) alignment 
Range on Protein: 8-229
Range on HMM: 50-270/283.0
IHDDPES-EYYNANWVR--GADGNPKAYVAAMGPLPATLTHFWRTIWESNVSAIIMATGLIEKGKTKCERYWPAEvdgkTAMHFGDIVVLSVSEAKAKGY
.. ..|| .| || ..     . . | |..| .||  |   ||. ... ...||.| | | |  . || .||| .     .. .|.  |    |   . .
velksesrdyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfdekitaivmltklqedlrikCsqyWPkr....GsedyGeftvtlrkettsnsf

IFTQLKVVRHGE---SRRIGHFWYNTWpdhgvprdaeRSLYPDSVLGLL---HTVHKWNSKFKDQPTLVHCSAGIGRTGTLIVIDHCRQLLKTQMRADPL
|  .| .   .    .  . |. .. |           .  .....  |     |     . |. | .||||.|||||...| .    . ..|.   |  
iikelllrvnssakstlllahyqvidW..........leygeqaiinslvkfnkvislqteskkgPivvhCstgiGrtavfiaasasvkdaltesvvdvf

AIIEAVRQDRPALVQHLQQ--VLHHGV--SDSCGD
|... .|..|. .|| |.|  ..|. |     |||
avvkimreqrmmavqtldqyklvhelvleqalcgd
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 2-217 2.5e-30 100.1 In-house 61-224 (392) alignment 
Range on Protein: 2-217
Range on HMM: 61-224/392.0
RVVLPRIHDDPESEYYNANWVRGADgNPKAYVAAMGPLPATLTHFWRTIWESNVSAIIMATGLIEKGktkcerywpaevdgktamhfgdivvlsvseaka
||.|  | | |.|.|.|| .... | | |||.|. || .|.|  ||| ... ||..|.| | | |                                   
rvkleviddipdsdylnasyipsfd.nekayiasqgpnaaslddfwrmvfqenvttiamvtklkegd.................................

kgyiftqlkvvRHGESRRIGHFWYNTWPDHGVPRDAerslypDSVLGLLHTVHKWNSKFKdQPTLVHCSAGIGRTGTLIVIDHCRQLLKTQMRADPLAII
           .  . | .  | .  |||..||. .       |.| ... |.    ..  .| ..|||||.|||| .| ||      |.    | . ..
...........kgddartvaqfhftewPdkdvpkht......ssllkfikevkadfGqyt.hpliihcsagvgrtgvvisidsvvahakktrmvdvfnfv

EAVRQDRPALVQHLQQ
  .|. || .||  .|
tnirrkrpymvqtkeq
subfamily_CG7180_pd Subfamily CG7180 2-217 6.9e-30 98.7 In-house 58-278 (296) alignment 
Range on Protein: 2-217
Range on HMM: 58-278/296.0
RVVLPRIHDDPESEYYNANWVRGADgNPKAYVAAMGPLPATLTHFWRTIWESNVSAIIMATGLIEKGKtKCERYWPAEVdgktAMHFGDIVVLSVSEAKA
||||.... . .|.| || .| .    .|.|.   .|   |.  ||| ... ..||... |   .  | ..  ||| .       ..|.|.|  |.| . 
RvvLekldGeeksdYinavyvdsfl.kkkeyivteapkketvdefWrlvydeeisavvvLtktfdfak.mypsywpnks....keqygeifveiveekqy

KGYIFTQLKVVRH------------GESRRIGHFWYNTWPD-HGVPRDAerslypDSVLGLLHTVHKWNSKF----KDQPTLVHCSAGIGRTGTLIVIDH
      ..|....             | | . .| . .|.  . ||  .       ... |.. |..|  |     . .|..|..| | .|.|  . || 
anlkirtfkltkkivalteqekqvkaetRivklfqlteWeledkvPlst......nalielrrrvrlwrekvdedpeegPvvvvssdGasRsGvylaida

CRQLLKTQMRADPLAIIEAVRQDRPALVQHLQQ
. .|.. . . |    .  .|..|| ||.  ..
nlelvekeeevdvFeavktlrrsRpqLvenvee
0044763 (Phosphotyrosine protein) phosphatases II 1-218 9e-29 95.8 In-house 5-160 (178) alignment 
Range on Protein: 1-218
Range on HMM: 5-160/178.0
TRVVLPRIHDDPESEYYNANWVRgadgnPKAYVAAMGPlpatlTHFWRTIWESNVSAIIMATGLIEKGKTKCERYWPAEVDgktamhfgdivvlsvseak
|||.|. . . . |.|.||...      |  |... .|      .... ..| ....|.. |. .| |. || .||| | .                   
trvllsnleglersdyinaseil.....pglylgslpp.....addlellkelgithivnlteelelgflkcdpywpeeag...................

akgyiftqlkvvrhgesrriGHFWYNTWPDHGVPRdaerslYPDSVLGLLHTVHKWNSkFKDQPTLVHCSAGIGRTGTLIVIDHCRQLlktqmRADPLAI
                     .. .  .||||||        .. .| ... .... .  |. |.|||||||.||.|||.... ...|     . .. ..
....................iqylhipipDhgvpd......llehflefvefieeald.ekggpvlVHCsaGvgRsgtlvaaylmkkl.....glsleea

IEAVRQDRPaLVQHLQQV
|| ||. ||  |..  |.
ielvrerRp.ivpnpgql
subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 12-219 3.7e-28 93.0 In-house 64-259 (281) alignment 
Range on Protein: 12-219
Range on HMM: 64-259/281.0
PESEYYNANWVRGADgNPKAYVAAMGPLPATLTHFWRTIWESNVSAIIMATGLIEKGKTKCERYWPAEVdgKTAMHFGDIVVLSVSEAKAKGYIFTQLKV
  ..|  ||..|      . |. . ||   | . ||| ||. | .||.|   ..|  . ||  |.| .   . ...|  . |     .  |  . |.|..
nstdyihanyirspf.lkrgyiltqgpkketradfwrmiwqenttaivmlcqfletnrekcaeyfprna..hcclqfdklsvsyedstvnkslvttrlnl

VRHGESRRIGHFWYNTWPDHGVPRDAErslypdSVLGLLHTVhkwnsKFKDQPTLVHCSAGIGRTGTLIVIDHCRQLLKTQMRA-DPLAIIEAVRQ-DRP
   ||.| | |. .. |||  ||  .|       .| .|. .     . .  | ..|||||.||.|||. .. . | .....   |   |.  .|   | 
syegetrlithwlwkewpdwqvpesse......vmlkilrki.....rarstppvihcsagvgrsgtlmaveialqsihshftlpdikqivshlrvtgra

ALVQHLQQVL
| || ||| .
asvqtlqqym
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 9-219 9.2e-28 91.7 In-house 75-279 (305) alignment 
Range on Protein: 9-219
Range on HMM: 75-279/305.0
HDDPESEYYNANWVRGADGNPKAYVAAMGPLPATLTHFWRTIWESNVSAIIMATGLIEKGKTKCERYWPAEVDGKTAMHFGdIVVLSVSEAKAK----GY
.. . |.|  ||.|       | ...| |||  |. .||  . . .|  |.|    .| || || .||||    |  .. | |||  || .|        
dkpspsdyihanyvgcpmipekrficaqgpldqtidefwwmviqnkveqivmlcktvelgklkcaqywpaaqgeklelksg.ivvenvsgskpmerdaei

IFTQLKVVRHGE-SRRIGHFWYNTWPDHGVPRDAERSlypdsvLGLLHTVHkwNSKFkdqPTLVHCSAGIGRTGTLIVIDHCRQLLKTQMRADPLA-IIE
  | |..   |. .  . |. .. ||| |||     |      | || ..    ||    | .||||||||||||.. |..  . .  . .. |.  .. 
qitllnltysgdqkmsvrhlqwtewpdrgvppcklts......lellsair..gskv...pivvhcsagigrtgtivaieyilekiaenkpcppmpelvk

AVRQDRPALVQHLQQVL
|.|..|   .|   | |
alrdqrafsiqndvqyl
0049772 (Phosphotyrosine protein) phosphatases II 1-218 2.3e-27 92.0 In-house 60-269 (314) alignment 
Range on Protein: 1-218
Range on HMM: 60-269/314.0
TRVVLPRIHDDPeSEYYNANWVRGAdgnpKAYVAAMGPLPATLTHF----------WRTI--WESNVSAIIM---------------------ATGLIEK
.||.||. . .  | |.||..|.|     ....|. |||. |.  |          || .  .. ||  | |                      ..| ..
nrvilpglpvsg.sdyinasyvdgf....lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivmsrdevladelsrLdaAlgKtpllildgn

GktkcerywpaevDGKTAMHFGDIVvlsvseakakgyiftqlKVV--RHGESRRIGHFWYNTWPDHGVPRDAErslypdsVLGLLHTVHKWnskFKDQPT
|            .  ||... ..                  ...  ..  .|.. ....  .||...| ..        .. .|. ....    |. |.
g............neptaadlellk.................eelydpelferlgikylripvpDgsaplled.......fdeflefieea...dkggpv

LVHCSAGIGRTGTLIVIDHCRQLLktqmRADPLAIIEAVRQDRP-----ALVQHLQQV
||||.||.|||||..|.. .  ||    . ..  ..| ||. ||      ... |.| 
lvHCkaGkgRtgtfvvaaylmkll....gvsleealedvrlkRpinpnpgfieqleqy
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 13-220 3.1e-27 90.1 In-house 72-278 (305) alignment 
Range on Protein: 13-220
Range on HMM: 72-278/305.0
ESEYYNANWVRgADGNPKAYVAAMGPLPATLTHFWRTIWESNVSAIIMATGLIEKGKTKCERYWPAEVDGKTAMHFGD--IVV-------LSVSEaKAKG
  ||  ||.|  .  ||| .. .  ||  | . ||   .. .| ||.|   |.|||  ||  |.... . .  .. ..  |.|       |.  . .|| 
pheyihanyvs.tptnpkrfictqaplektcadfwymclqdkveaifmlcnllekgakkcleyfaskdkdvlefeekgqkisvkfessvtlkfrk.daka

Y-IFTQLKVVRHGE-SRRIGHFWYNTWPDHGVPRdAERslypdSVLGLLHtvhkwNSKFKDQPTLVHCSAGIGRTGTLIVIDH-CRQLLKTQMRADPLAI
    |.| .   || .|.. |. .. ||| |||  |.      ..| ||.     ...    |. |||||||||||....... . |||  |.  |   |
kvtetvlviegpgekarkvthyhwidwpdrgvpa.adl.....ailelle.....karpskgpivvhcsagigrtgsvvmleyildqllagqiiedtdki

IEAVRQDRPALVQHLQQVLH
.  .|..|   .|  .| | 
lqkireqrnnsiqtdaqylf
PTPc_DSPc_SM00012 122-219 3.4e-27 90.1 In-house 4-97 (105) alignment 
Range on Protein: 122-219
Range on HMM: 4-97/105.0
HFWYNTWPDHGVPRDAerslypDSVLGLLHTVHKWNSKFKD-QPTLVHCSAGIGRTGTLIVIDHCRQLLKTQ-MRADPLAIIEAVRQDRPALVQHLQQVL
|..|..|||||||...      ||.| ||. |.|...| .. .|..||||||.|||||....| . | |...  . | . |....|. || .|| ..|.|
hyhytgwpdhgvPees......dsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqyl
0051082 (Phosphotyrosine protein) phosphatases II 14-219 3.9e-27 90.1 In-house 3-143 (151) alignment 
Range on Protein: 14-219
Range on HMM: 3-143/151.0
SEYYNANWVRGAdgnpkaYVAAMGPLPatltHFWRTIWESNVSAIIMATGLIEKGktKCERYWPAEVdgktamhfgdivvlsvseakakgyiftqlkvvr
| |.|...| |       . .  |||.    .|.....| ....|.. ... | |  .| .|.|..                                  
sdyinfsyvtgg......lyrsggpla....dflellkelgiktivnlrseeerg..ycpeylpelg.................................

hgesRRIGHFWYNTWPDHGvprdaeRSLYPDSVLGLLHTVHKwnskFKDQPTLVHCSAGIGRTGTLIVIDHCRqlLKtqmrADPLAIIEAVRQDRPALVQ
    ... |...  |||.|       .|..|.|| .|. . .     |..|.|||||||.||||||.... .   |.     .. ...| .|. || .||
....ievlhipildwpdpg......lplsfdavleflellld....kkngpvlvHCsaGkgRTGtlvalylml..lg....vsleealeeyrlkrpgvvq

HLQQVL
. || |
pnqqfl
subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 1-223 4e-27 89.9 In-house 50-264 (285) alignment 
Range on Protein: 1-223
Range on HMM: 50-264/285.0
TRVVLpRIHDdpeSEYYNANWVRGADGNPKAYVAAMGPLPATLTHFWRTIWESNVSAIIMATGLIEKGKTKCERYWPAEVDGKTAMHFGDIVVLSVSEAK
||||| . ||    .|  |.|.|    .  .|... |||| ||. ||. |.. ... ..|   |.| |  ||  |.| ..     .   .| .  . |  
trvvl.knhd...rdyihaswmrmpgkdqstyittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekcalyypeklgevvkfgkyeitlteckeea

AKGYIFTQLKVVRHG----ESRRIGHFWYNTWPDHGVPRDAErslypdSVLGLLHTVHKWNSkfKDQPTLVHCSAGIGRTGTLIVIDHCRQLLKTQMRAD
  | |.  | |.       |   . |     |||.  | ||        .. | . |.| |   |..|  ||||||.||| |.. ||..   .  .   .
iagtilnaltvintedasseplymnhvqvpwwpdqlapedar......pmielykwvkkvnp..kekpicvhcsagvgrtatfvgidyatirimenpnie

PLAIIEAVRQDRPALVQHLQQVLHHGV
 | |.  .|  |   ||   |.|   |
mldivremramrfqavqshmqflflyv
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 7-217 3.2e-26 87.0 In-house 61-259 (288) alignment 
Range on Protein: 7-217
Range on HMM: 61-259/288.0
RIHDDPEseYYNANWVRGADGNPKAYVAAMGPLPATLTHFWRTIWESNVSAIIMATGLIEKGKTKCERYWPAEVDGKTAMHFGDIVVLSVSEAKAKGYIF
...|||.  .| |  |  .  ...  . |  || .|.  .|. . ||.|  |.| . |.|||| | . |.| ..  |. .     ||    .   |    
klsddpd..fyiaanvvssakykrrlicaqaPlngtieelWkmllesdveyivmlcellekGkeksaeyfPsklGekarigrlctvvkkkradidklvkv

TQLKVVRHGESRR-IGHFWYNTWPDHGVPRDAErslypdSVLGLLHTVhkwnsKFKDQPTLVHCSAGIGRTGTLIVIDHCRQLLKTQMRADPLAIIEAVR
. |.. ..|| .  . .  .. |.|.||| .        | | ||. .     |  ..| .||.|||.|||||||.|    . |. .       ...  |
sllriskegeekvivkilhlleWdddgvPenyl......splrllevl.....kslqkPivvhssaGvGrtgtlililialeslrlddflgirsllaklr

QDRPALVQHLQQ
..|   .|  .|
eerfkaiqtemq
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 11-219 1.1e-23 78.6 In-house 54-249 (267) alignment 
Range on Protein: 11-219
Range on HMM: 54-249/267.0
DPESEYYNANWVRGADGNpKAYVAAMGPLPATLTHFWRTIWESNVSAIIMatgLIEKGKTKCERYWPAEVDgkTAMHFGDIVVLSVSEAKAKGYIFTQLK
. | || || .| |   . .|...  .||  | |.|.  | . .|. |..   |   .. .  ..|| ..    | .. |..|    | . . |    |.
tkeeeyinasyvegyktk.nafivtqdplkntitdfltvihdqkvpvivl...ltkvftdnirlfwPPkmg..qakkyqdltvehslekeendyqiitle

VVRHGES-RRIGHFWYNTWPdhgVprDAERSLYPDSVLGLLHtvhKWNSKFKDQPTLVHCSAGIGRTGTLIVIDHCRQLLKTQMRADPLAIIEAVRQDRP
.  . || . .  ..|. |    .  ...   |   ..|.|    | . .  ..| .|.||.|.||.||..|||   . .||.  .|    .  .|. |.
lkfknesahnvtlyyykkwn...i..ntnnkpylkplfgila...knqlengnrPlvvacsdGvGrsGtflvidsqleraktegvsdifdflrkirsqri

ALVQHLQQVL
.||. ... .
glvdtkeryi
subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 13-219 1.7e-23 77.8 In-house 66-266 (312) alignment 
Range on Protein: 13-219
Range on HMM: 66-266/312.0
ESEYYNANWVRGAdGNPKAYVAAMGPLPATLTHFWRTIWESNVSAIIMATGLIEKGKTKCERYWPaEVDGKTAMHFGDIVVLSVSE----AKAKGYIF-T
|  |  ||.|.    .|. .|.. |||  | ||||.       ..||. .|..| |  || .|   .. |   .    .   ...|     |.|  |   
enfyihanfvkic.tkperfvctqgplentcthfwqlalslgstsiillcgfvedgsekcakyis.divgfvdledhrvyteycteieiggkskdkithr

QLKVVR--HGESRRIGHFWYNTWPDHGVPRDAerslypDSVLGLLHTVHKwnskfKDQPTLVHCSAGIGRTGTLIVIDHCRQLLKTQMRADPLAIIEAVR
 ||||    |.  .. |. . .|||||.|         |. | || .|.|       .| . |||||.||||||..|.     |.   . .   .   .|
vlkvvvkatgqesklnhyqwaswpdhgmpdsc......dtalrllsavkk.....dkkpviahcsagvgrtgtlaliesmiaalrhprkqnvkdsfvllr

QDRPALVQHLQQVL
.||   |. . | .
kdrarsvrvfpqyv
subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 18-218 4.4e-23 76.5 In-house 79-270 (301) alignment 
Range on Protein: 18-218
Range on HMM: 79-270/301.0
NANWVRGAdGNPKAYVAAMGPLPATLTHFWRTIWESNVSAIIMATGLIEKGKTKCERYWPAEVDGKTAMHFGDIVVLSVSEAKAKGYIFTQLKVVRH---
 |||.    |.|. ..|. |||..|   ||  .   .|  |.| .  .|| ..||| | | ..  |  .   .| . .      |  .  .|.|.     
hanwipts.GhphrfiatqgPlkntsedfwamlvqydvekivmlgqkvekleekceeylpvkisekldigrfkikiknkelilnkkiskrtlevedstgk

GESRRIGHFWYNTWPDHGVPRDAErslypdSVLGLLHTVHKwnskfKDQPTLVHCSAGIGRTGTLIVIDHCRQLLKTQMRADPLAIIEAVRQDRPALVQH
 ..| . |. |..|.|.|||.          .  |.. | |      ..| .|||||||||. ..|  .   . .... . .    .. .|..|   ||.
fatrtvthyqysewtdrgvPksha......elfdlmelvkk.....sekPivvhcsaGiGrsvafigteylareveadptieltealkhlrehrwngvqt

LQQV
 .|.
nsql
subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 37-219 6.1e-22 72.4 In-house 98-278 (302) alignment 
Range on Protein: 37-219
Range on HMM: 98-278/302.0
GPLPATLTHFWRTIWESNVSAIIMATGLIEKGKTKCERYWPAEVDGKtaMHFGDIVVLS--VSEAK-----AKGYIFTQL----KVVRHGESRRIGHFWY
 |   ||  .|  | . ||. ..  ....|... ||  |.  .|.|.  ..||   | .  | .        |.. . ..    . ...   . .  . .
vpkkstlekhwalieqynvaivvqlcsfvedeekkcaeyysdkvgge..lkfgrytvktvsvktdleeftdkksfklytveiknekkkkkvkktvdilaf

NTWPDHGVPRDAERSLypdsvlGLLhtvhKWNSKFKDQpTLVHCSAGIGRTGTLIVIDHCRQLLKTQMRADPLAIIEAVRQDRPALVQHLQQVL
 .||||| |..|. .|       .|    |.   .| .  |||||||.||||||. | .  || ...  .| | |.  ||| |   ||. ||..
sawpdhGapkeaytal......dil....kfcesykkn.vlvhcsaGvGrtGtlvaikyGiqlcskkkvtdllsivlpvrqcryGavqdeqqli
0048076 (Phosphotyrosine protein) phosphatases II 75-218 6.7e-20 66.7 In-house 2-132 (145) alignment 
Range on Protein: 75-218
Range on HMM: 2-132/145.0
YWPAEVDGKtaMHFGDIVVLSVSEAKAKGYIFT--QLKVVRHGESRRIGHFWYNTWPDHGVPRdaerslYPDSVLGLLHTVHKWNSKfkDQPTLVHCSAG
|||.|....  . .|.. . .  |  ..  | |   |   .....| . ...|  |||||||        .. .| .|. .... ..  . |.|||||||
ywpseilpg..lylgslptaldlellkdlgittvlnltselellerlgiqylylpwpDhgvpd......llellleflefieealke..ggpvlVHCsaG

IGRTGTLIVIDHCRQllktqMRADPLAIIEAVRQDRPALVQHLQQV
.||||||.... ...     .. ..  ..| ||. ||  |.. .|.
vgRtgtlvaaylmll.....lgvsleealelvrsqrpgavpnpgql
subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 42-209 2.1e-19 64.6 In-house 40-201 (255) alignment 
Range on Protein: 42-209
Range on HMM: 40-201/255.0
TLTHFWRTIWESNVSAIIMATGLIEKGKTKCERYWPAEVDGKTAMHFGDIVVLSvseAKAKGYIFTQLKVVRHG---ESRRIGHFWYNTWPDHGVPRDAE
|. .|..||  .. . ..| . . |.|. ||..|.| | |.|  ..  ....     . |.  . |   .   |   . . . |. |. |...  |..|.
tvdkfyqtivqtktevvvmlcdfaeegvekcssyfplekdeklkladvnvtttk...ssadvvlrtleitstlgekkkthtvkhysykGWieknaPelar

RslypdsVLGLLHTVHkwNSkfkdQPTLVHCSAGIGRTGTLIVIDHCRQLLKTQMR------ADPLAIIEAVRQDRP
       .| .|. |.  .|    .. .||||.||||. ......   | .  ...       | | ..| .|. |.
e......ilnilkvvr..ds....ksvvvhCstGiGrsaafvlaelvyqkmirsldttetveldylslleelrskrk
0048179 (Phosphotyrosine protein) phosphatases II 118-218 1.2e-18 62.7 In-house 47-134 (144) alignment 
Range on Protein: 118-218
Range on HMM: 47-134/144.0
RRIGHFWYNTWPDHGVPRDAerslypDSVLGLLHTVHKWNSkfKDQPTLVHCSAGIGRTGTLIVIDHCRqllktQMRADPLAIIEAVRQDRPALVQHLQQ
| . ....  ||||||| ..      . .| .|. .... .  .. |.|||||||.||||||.... ..      .. ..  ... ||. ||  |.. .|
regiqylhlpwpDhgvpdll......ellleflefieeale..eggpvlVHCsaGvgRtgtlvaaylmk.....klglsleealalvrsrrpgavpnpgq

V
.
l
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 112-221 6.7e-16 52.6 In-house 83-188 (440) alignment 
Range on Protein: 112-221
Range on HMM: 83-188/440.0
VRHGESRRIGHFWYNTWPDHGVPRDAerslypDSVLGLLHTVHKWNSKFKDQPTLVHCSAGIGRTGTLIVIDHCRQLLKTQMRADPLAIIEAVRQDRPAL
.   ||| . .. |. |||.|||. |        || ... | . . |  . | ||||||| |||| .|..|   .  |   . | ...|...|..|| .
ingiesrtlkqyhyqgwpdkgvpkfa......gpvlkmiqdvnesqekagngpllvhcsagagrtgviiavdsilreakrsdqidifsfinsmrnnrpqm

VQHLQQV--LHH
||  .|   .|.
vqtpeqyafvhe
subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 8-214 1.1e-15 52.0 In-house 73-275 (310) alignment 
Range on Protein: 8-214
Range on HMM: 73-275/310.0
IHDDPESEYYNANWVRGADgNPKAYVAAMGPLPATLTHFWRTIWESNVSAIIMATGLIEKGKTKCERYWPAEvdGKTAmHFGDIVVLSVSEAKAKGYI--
|      .|  ||.|.      .... . |||  |.  ||| |..    .|..     |.|. ||  |||.   | |   .| | |  .||.  .  |  
idksryedyihanyvktny.lrstficsqgplqhtiidfwrmifqeraesilllckvgeegrpkcvgywpsl..gvte.tygcirvtnlsesseefeicn

------FTQLKVVR---HGESRRIGHFWYNTWPDHGVPRDAeRSLYPDSVLgllhtvhkwnSKFKDQPTLVHCSAGIGRTGTLIVIDHCRQLLKTQMRAD
        .. |       .  |.    .  ||| ||| .      |. .|          .. .  | .||||||..|..... ..   . |.   . |
lavtfvpdnvpvdeqpanlkelrvslikwpnwpdrgvpdek.chtvpqrll..........aqvrhgpcvvhcsagkdrlyvvvalklkidkldrglkvd

PLAIIEAVRQDRPALVQH
   ..  ....|   .| 
aeevktellksraiciqt
subfamily_hpo-7_pd Subfamily hpo-7 39-208 2.9e-15 50.9 In-house 43-206 (263) alignment 
Range on Protein: 39-208
Range on HMM: 43-206/263.0
LPATLTHFWRTIWESNVSAIIMATGLIEKGKTKCERYWPAEVDGKTAMHFGDIVVLSVSEAKAKGYIFTQLKVVRHGESRRIGHFWYNTWPDHGVPRDAE
|  |.  |..||  .. . ..| .   |.|. ||..|.| | |.|  ..  ....  | .   .  .     . .  . . . |. |. |...  |..|.
lvqtidkfyqtivqtktevvvmLcDfneegvekcssyfPlekdekqklanvnvcttkvqsdvllktlellstlgeKkkthtvkhysykgWiekndpelar

RSLYpdsvlgLLHTVHkwNSkfkdQPTLVHCSAGIGRTGTLIVIDHCRQLLKTQMR------ADPLAIIEAVRQDR
 .|.      .|. .   ||    ..  ||||.||||.    |..   | .  ...       | | ..| .|. |
eiln......ilkvar..ns....kslvvhcstGiGrsaafsvaElvyqkmirsldttstveldylsLleelrssr
subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 30-215 8.6e-15 49.4 In-house 5-190 (199) alignment 
Range on Protein: 30-215
Range on HMM: 5-190/199.0
KAYVAAMGPLPATLTHFWRTIWESNVSAIIMATGLIEKGKTKCERYWPAEVDGKTamHFGDIVVLSVSEAKAKGYIFTQLKVVR----HGESRRIGHFWY
. |.|.  ||  |.. ||. .||.    |.|      . ..    |||.   | .  ..| . | . . .    |  | | ..        .| | |. .
rryiatqhplretmadfwqmvwetgsghivmvnddqknkeadypfywpttesgtg..kygslsvttktittkpdytitaliltnnttappstreishyqf

NTWPDHGVPRDAersLYPDSVLGLLHtVHKWNSKFKDQPTLVHCSAGIGRTGTLIVIDHCRQ---LLKTQMrADPLAIIEAVRQDRPALVQHL
 .| ..  |  |   |.   |.     | |   . || | .|||| | | || .. .|   .     || .  | . .   .|| |  ..  |
tswkekttpnva...lfvgfvvasre.vskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsv.vdlfevakrlrqarcgiissl
subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 30-215 9.5e-15 49.3 In-house 4-189 (198) alignment 
Range on Protein: 30-215
Range on HMM: 4-189/198.0
KAYVAAMGPLPATLTHFWRTIWESNVSAIIMATGLIEKGKTKCERYWPAEVDGKTamHFGDIVVLSVSEAKAKGYIFTQLKVVR----HGESRRIGHFWY
. |.|.  ||  ||. ||. .||.    |.|      . ..    |||.   | .  ..| . | . . .    |  | | ..        .| | |. .
rryiatqhplretladfwqmvwetgsghivmvnddqknkeadypfywpttesgtg..kygslsvttktittkpdytitaliltnnttappstreishyqf

NTWPDHGVPRDAersLYPDSVLGLLHtVHKWNSKFKDQPTLVHCSAGIGRTGTLIVIDHCRQ---LLKTQMrADPLAIIEAVRQDRPALVQHL
 .| ..  |  |   |.   |.     | |   . || | .|||| | | || .. .|   .     || .  | . .   .|| |  ..  |
tswkekttpnva...lfvgfvvasre.vskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsv.vdlfevakrlrqarcgiissl
subfamily_egg_pd Subfamily egg 15-213 4.2e-14 46.9 In-house 69-254 (307) alignment 
Range on Protein: 15-213
Range on HMM: 69-254/307.0
EYYNANWVRGADgNPKAYVAAMGPLPATLTHFWRTIWESNVSAIIMATGLIEKgkTKCERYWPAEVDGKTAMHFGD--IVVLSVSEAKAKGYIFTQLKVV
..  || |.|       .. |  ||  |   ||| ... .|  |.| |   |    .|| |||   .    .  |   |  | | ..    .  |.||.|
dfihanrvkGkp.llnefilaqaplkntvddfwrmvfqeevqyivmltsrkes..erceyywpkaesdslvtvpGslrienlkvdskadplfrvtklklv

RHGESRRIGHFWYNTWPDHGvprdaeRSLYPDSVLGLLHTVHKwnskfkdqPTLVHCSAGIGRTGTLIVIDHC-RQLLKTQMRADP-LAIIEAVRQDRPA
   .  |    |   .   .         .|  || .|  . |        |..|..  |. ...||. |.    .||.  .   . |  .  .|. |. 
Ggddeerflehwqgdvnnss......dvysplrvlrklrnlsk........pvvvqdilGvskaatlvaieiallsllrGpitkslvlravvflrlrrrl

LVQ
 |.
sve
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 12-78 4.4e-13 43.7 In-house 81-152 (350) alignment 
Range on Protein: 12-78
Range on HMM: 81-152/350.0
PESEYYNANWVRGA----DGNPKA-YVAAMGPLPATLTHFWRTIWESNVSAIIMATGLIEKGKTKCERYWPA
  ..| |||... .    . ||.  |.|. .||| |.  |.. | . .|  |.. | ..| .  ||.|||. 
stnDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvkvilsltsdvelnlekcyrYWqe
subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 41-213 8.7e-13 43.0 In-house 78-243 (290) alignment 
Range on Protein: 41-213
Range on HMM: 78-243/290.0
ATLTHFWRTIWESNVSAIIMATGLIEKGKT----KCERYWPAEVDGKtaMHFGDIVVLSVSEAKAKGYIFTQLKVVR-HGESRRIGHFWYNTWPDHGVPR
.|. .|| .. . .|  ..|     || .      |..| | .|...  . |... |   |  | .. .  .| |    .|   . | ... | .  |..
StiekfwwmakqEkvkqvVmlcefeeksantslfaCakYvpesvgee..lkfkgltvkCkskekeddvetRelvvkfddeeeftvtHsllkgWnklnvqe

DAErslypdSVLGLLHTVHkwnskFKDQPTLVHCSAGIGRTGTLIVIDHCRQLLK-TQMRADPLAIIEAVRQDRPALVQ
|        ..| |...|.      .. | .|||  || |  .|  |.   |..  |.      ....|.|. |  ...
dtk......tllsliqkvk.....asktpvivHcvdGiSrsAalaaiilgyQkiaetsgsvkledvlkalrkqralait
0038934 (Phosphotyrosine protein) phosphatases II 142-218 5.6e-11 37.9 In-house 95-166 (194) alignment 
Range on Protein: 142-218
Range on HMM: 95-166/194.0
YPDSVLGLLHTVHKWNSKFKDQPTLVHCSAGIGRTGTLIVIdhcrqLLKTQMRADPLAIIEAVRQDRPALVQHLQQV
  . .|  |. |...... ...  .||| ||.||||||..       |   .. .. . |. .|. ||  ... ...
sleillrfldlvdeflnedpggvvaVHCkaGlgRtGtlvaa.....YLiyrlgmsaeeAialfrekRpgaipnqdyl
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 120-187 1.7e-10 35.2 In-house 217-287 (350) alignment 
Range on Protein: 120-187
Range on HMM: 217-287/350.0
IGHFWYNTWPDHGV---PRDAERSLY--PDSVLGLLHtvHKWNSKFKDQPTLVHCSAGIGRTGTLIVIDHCRQ
. .. .. |.| ..   |..  ..|   .| .  |    ...  . . .| |||||||.||||||. .|.  .
vyqlqvknWkDlslllnPesilqalevkndliddlfa..eshldnarsspilvhCsaGvGrtGtlvtlDslls
subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 13-218 6.3e-10 33.1 In-house 68-268 (303) alignment 
Range on Protein: 13-218
Range on HMM: 68-268/303.0
ESEYYNANWVRgADGNPKAYVAAMgPLPATLTHFWRTIWESNVSAIIMATGLIEKGKTKCERYWPAEVDgktAMHFGDIVVlSVSEAK----AKGYIFTQ
.| |  |...   | . || .. . ||. | . ||. | | .|  ...     |  |   .  .| . |    ..| . ..  | | |    ..|. .  
dssyihasyle.ldsskkailtql.plshtaadfwqmiieqkvkcvlllltdseydklggdsvfprnqd...flkfeersi.rvgefkrvelgdgwvlkv

LKVvRHGESRRIGH-FWYNTWPDHGVPRDAERSlYPDSVLGLLHTVHKWNskfKDQPTLVHCSAGIGRTGTLIVIDHCRQLL-KTQMRADPLAIIEAVRQ
| |   |. . . |   |..||   .| |.    .   .  |   . |.    . .||.    .| ||.||. ... .   | . |   | .  .| ||.
lsv.sngdyksflhvhhykawphnsipsdgspk.fvkqiwqlqsvlrkys...dstptvymslsgcgragtfalfetahlslhseqasldlvkclenvrn

DRPALVQHLQQV
 |   || | | 
grlhavqnlsqf
subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 16-217 3e-09 30.7 In-house 77-273 (302) alignment 
Range on Protein: 16-217
Range on HMM: 77-273/302.0
YYNANWVRGADGNPKAYVAAMGPLPA--TLTHFWRTIWESNVSAIIMATGLIEKGKtKCERYWPAEVDgkTAMHFGDIVVL--SVSEAKAKGYIFTqLKV
|.||  |   . ... ..| .  .     . .||| ... ..  . .. |  |  |   . ..| . .  .  ..|.. |    |..|... . .. . |
yvnaskvevPeltrsiilaQlpkvdsedsveeFWrmvfqekivsvvilvgeeelkk.tlselfpkksg..dykeygkmfvNnrkVekaeeektryv.iEv

VRHGESRRIGHF--WYNTWPDHGVPRDAERSLypDSVLGLlhtvHKWNSKfKDQPTLVHCSAGIGRTGTLIVIDHCRQLLKTQMRADPLAIIEAVRQDRP
. .| |  .       . |... ||    .     .. ..    .. ..|  |..|..    |.|| |....     . |...       |....|..||
lPegcsnsvlanvyvltnWkqkkvpvkyaeli..ktaakv....fakkik.adentvivSknGaGRagafltlavaveklqkgkepnikeivksiRsqRp

ALVQHLQQ
. |. |.|
ravdslkQ
subfamily_CG42327_pd Subfamily CG42327 161-217 5.3e-09 30.2 In-house 246-303 (319) alignment 
Range on Protein: 161-217
Range on HMM: 246-303/319.0
KDQPTLVHCSAGIGRTGTLIVIDHCRQLLKTQ-MRADPLAIIEAVRQDRPALVQHLQQ
.  |  |||| |.||||..|  |   . |..     |   ..  ||.||   |.  .|
sqGPlvvhcsdGvGrtGlviasdiairsleeskrsvdiPqlvssvrrdrasavltkeq
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 14-77 2.3e-08 27.8 In-house 90-154 (349) alignment 
Range on Protein: 14-77
Range on HMM: 90-154/349.0
SEYYNANWVRGADGNP-KAYVAAMGPLPATLTHFWRTIWESNVSAIIMATGLIEKGKTKCERYWP
 .| |||... .  .. | |.| . |||.|.  |.. |   .|  ..  .   |..  ||..|| 
ddyinanylkltrisvekkyiatqaPlPstvddfykvillngvklvlsLnddkelslekcdiywq
subfamily_PTPDC1_pd Subfamily PTPDC1 149-218 2.8e-08 28.4 In-house 101-165 (182) alignment 
Range on Protein: 149-218
Range on HMM: 101-165/182.0
LLHTVHKWNSKFKDQPTLVHCSAGIGRTGTLIVidhCRQLLKTQMRADplAIIEAVRQDRPALVQHLQQV
.|  |   ..  ... . ||| || |||| ||    |  . .... |.    |. ||. ||  .|  .||
iLdivkvvafalqegkvavhChaGlGrtGvlia...cylvyakrltae..kaiklvrskrpksiqtreqv
subfamily_eak_pd Subfamily eak 32-188 2.5e-07 24.4 In-house 95-262 (332) alignment 
Range on Protein: 32-188
Range on HMM: 95-262/332.0
YVAAMGPLPATLTHFWRTIWESNVSAIIMATGLIEKGKTKCERYWPAEvdGKTAMHFGDIVVLSVSEAKAKGYIFTQLKVVRHGESRRIGHFWYNTWPDH
|. .  .    .  ||. . | .  ||..    .|..  | ..|.| .  ..  ..|| . |   .  | . . . .|.. .  |. |. |. .  | . 
yiltGiasedkvfafwqmvleqkspaivqlledvelkleksdkyfpdk..treelkfGildverkefvkrniletrllelskGnethrvlhykvfGwtet

GVPRDAER----SLYPD-SVLGLLHTVH-KWNSKFK---DQ-P---TLVHCSAGIGRTGTLIVIDHCRQL
 .|.  .         .  || |. .     .| .|      |    .. .. |  |.|...|||   .|
tlpkyedflalrkvmkevGvlllivmksallsstlkkyihtppsfapiiqsarGsaraGvfvvidllirl
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 161-191 3.1e-07 24.0 In-house 264-294 (349) alignment 
Range on Protein: 161-191
Range on HMM: 264-294/349.0
KDQPTLVHCSAGIGRTGTLIVIDHCRQLLKT
.  . ||||||| ||||.|. .|   ..|. 
qlstllvhcsaGcGrtGvlvtldlllsilep
PTEN_1 162-211 4.6e-07 24.8 In-house 130-175 (196) alignment 
Range on Protein: 162-211
Range on HMM: 130-175/196.0
DQPTLVHCSAGIGRTGTLIvidhCRQLLKTQMrADPLAIIEAVRQDRPA-L
    |||| ||.||.||..    .  |....   ..   .| ||. ||.  
gnvVlVHCkaGlgRsGtvv....aayLmykgk.ltadeAlelvrekRppga
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 30-84 1e-06 22.3 In-house 236-287 (440) alignment 
Range on Protein: 30-84
Range on HMM: 236-287/440.0
KAYVAAMGPLPATLTHFWRTIWESNVSAIIMATGLIEKgktKCERYWPAEVDGKT
.|..|.  || .|.  ||| . . ..|.|||   | .|    |  ||| .    |
nafiatqmpldstvldfwrlvhdyristiimlnqlndk...tcsiywpvntrsvt
subfamily_PTEN_pd Subfamily PTEN 149-188 4.5e-06 21.8 In-house 101-140 (184) alignment 
Range on Protein: 149-188
Range on HMM: 101-140/184.0
LLHTVHKWNSKFKDQPTLVHCSAGIGRTGTLIVIDHCRQL
......|| .. |..   ||| || ||||.|||     .|
ivediekwleedkknvvvvHCkaGkGRtGvlivayllksl
subfamily_CDC14_pd Subfamily CDC14 166-218 7.5e-06 20.0 In-house 267-314 (328) alignment 
Range on Protein: 166-218
Range on HMM: 267-314/328.0
LVHCSAGIGRTGTLIVidhCRqLLKtQMRADPLAIIEAVRQDRPALVQHLQQV
 ||| ||.|||||||    |  |.| . |     .|  .|  ||  |   || 
avhCkaGLGrtGtLia...cy.lmk.hyrftaaeaiawlricrPGsvigpqqk
DSPc Dual specificity phosphatase, catalytic domain 161-211 8.7e-06 20.6 Pfam-A 72-117 (133) alignment 
Range on Protein: 161-211
Range on HMM: 72-117/133.0
KDQPTLVHCSAGIGRTGTLIVidhcRQLLKTQMRaDPLAIIEAVRQDRPAL
| .  |||| ||| |..|||.    . |.||.   .    .|.|...|...
kgkkvlVHCqaGisRSatlii....aYlmktknl.slneAyefvkerrski
DSPc Dual specificity phosphatase, catalytic domain 161-211 8.7e-06 20.6 In-house 72-117 (133) alignment 
Range on Protein: 161-211
Range on HMM: 72-117/133.0
KDQPTLVHCSAGIGRTGTLIVidhcRQLLKTQMRaDPLAIIEAVRQDRPAL
| .  |||| ||| |..|||.    . |.||.   .    .|.|...|...
kgkkvlVHCqaGisRSatlii....aYlmktknl.slneAyefvkerrski
0048567 (Phosphotyrosine protein) phosphatases II 150-219 8.9e-06 20.2 In-house 60-129 (157) alignment 
Range on Protein: 150-219
Range on HMM: 60-129/157.0
LHTVHKWNS--KFKDQPTLVHCSAGI---GRTGTLIV---IDHCRQllktqmraDPLAIIEAVRQDRPALVQHLQQVL
 . ..|. .  . ....  |||.||    |||.|||    | |..         .|  .|. .|. || .| . ..  
ilklnkflkilelagkaiavhckaglkkrgrtatLigcYlilhlgf........tpeeaiaplrivrpgsvpfrdasy