Gene MbrePTP-sf2-2 in Monosiga brevicollis

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily MbrePTP-sf2
Protein sequence
ID Type Fasta BLAST phosphatome Note
MbreP040_AA protein Get Run
MbreP040_AA_28-307 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 13-311 6.4e-118 387.6 In-house 1-269 (270) alignment 
Range on Protein: 13-311
Range on HMM: 1-269/270.0
YTRLDLQQPSLDAIPPYARGRVYNRYNDILPSPASRVILPEERGDPATTYINANYLP-FLGNPKAYIAAMGPLPTTIHSFLRMVIEHKTvamvcprsppp
. .|| ...| ...| .|||...|||.|||||||.||.|.|.. |.||.||||||.. | |..|.|||||||||||..||.||..|.|.           
fkeldkeetsesdlpeaargkklnRyadiLPsPatRvrleeleedsataYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekv...........

qsvsaihcppnmrrlPCLtmftrqVMTTNFEEKGRKKCECYWPELPQD--TMEFGDIKVFNEGQQQEQFFRITRLRLERGGTIHRVTHFFYNTWPDRGVP
               ...      ||||..|||||||||.|||. |..  ..|.|.|||... ...|.....||||||. |...|..||.||||||.|||
...............tai......vmttgleEkgrkkCerYWpaepkekvkledgkikvlalseekeegyiltrlrleekgeerrlvHfwyntWpdhgvp

RSDDNVMLTRGVVKMLAAVRRHRIQTDKATsPLLVHCSAGVGRTGCFVLIDQCFRLLEHNQRLDLAALIKENRRYRMAFVQTPEQFEFAWRTVAGYINFR
|..|... |. ..|||.||||.. ..|||. ||||||||||||||.....|...||||.....|..|.|.|.|..|||.||.|||.||....|. |...|
reedsslstdqllkmlravrrsekeldkae.PllvHcsaGvgRtGtlialDiavrlLeetkkvdvlaiieelRkdRmalvqhpeqyeflykavveyaerr

LK
.|
ak
0046845 (Phosphotyrosine protein) phosphatases II 33-310 3.2e-61 202.5 In-house 29-278 (284) alignment 
Range on Protein: 33-310
Range on HMM: 29-278/284.0
RVYNRYNDILPSPASRVILPEERGD-PATTYINANYLPFL-----GNPKAYIAAMGPLPTTIHSFLRMVIEHKTVAMVcprspppqsvsaihcppnmrrl
.  ||| ||||   |||.|  . || . ..||||.|...       ..|..||. ||||.|...| ||| |...   |                      
lsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweqnvrvIV......................

pcltmftrqvMTTNFEEKGRKKCECYWPELpQDTMEFGDIKVFNEGQQQEQFFRITRLRLER---GGTIHRVTHFFYNTWPDRGVPRSddnvmlTRGVVK
          | |...|.||.||. |||.  ......||..| .   .... . ...|.|..   .|  ..|||| | .|||.||| |      .. ...
..........mltelvengrekcaqYwple.gevltygdftvtllseevkddytvrtleltnlgytgesrtvthfhytswpdhgvpps......pedlle

MLAAVRRHRIQtDKATSPLLVHCSAGVGRTGCFVLIDQCFRLLEHNQ---RLDLAALIKENRRYRMAFVQTPEQFEFAWRTVAGYINFRL
.| .||... .  .  .| .|||||||||||.|...| ....||...   ..|.  ..|  |..|. .|||.||..|  .... |....|
flrlvrellen.lpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyealleylklkl
0051299 (Phosphotyrosine protein) phosphatases II 33-306 1.2e-60 200.7 In-house 50-286 (288) alignment 
Range on Protein: 33-306
Range on HMM: 50-286/288.0
RVYNRYNDILPSPASRVILPEERGDPATTYINANYLPFLGNPKAYIAAMGPLPTTIHSFLRMVIEHktvamvcprspppqsvsA---Ihcppnmrrlpcl
.  ||| ||||   |||.|  . |.. ..||||.|...  .....||. ||||.|...| ||| |.                     |            
leknRysdilpydhsRVkLsvldgvegsdYinAsyidgynlkrkfIatqgPlpntvedFWrmvweq.................nvrvI............

tmftrqVMTTNFEEKGRKKCECYWPElpQDTMEFGDIKVFNEGQQQEQFFRITRLRLE------RGGTIHRVTHFFYNTWPDRGVPRsddnvmLTRGVVK
      || |...|.||.||. |||.  ......|||.| .   .... . .. |...       .|. ..|||| | .||| |||        .. ...
......vmltklvelgrekcaqYwpl..ggsltygditvtllseevlddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpd......spellld

MLAAVRRHRIqtdKATSPLLVHCSAGVGRTGCFVLIDQCFRLLEHNQRLDLAALIKENRRYRMAFVQTPEQFEFAWRTVAGYI
.| .||...    .  .| .|||||||||||.|...| ....||.....|.  ..|  |..|.  ||||||..|  .... |.
flrlvrkala...sgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtpeqyrfvyealleyl
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 34-307 3e-57 188.8 In-house 30-269 (274) alignment 
Range on Protein: 34-307
Range on HMM: 30-269/274.0
VYNRYNDILPSPASRVILP-EERGDPATTYINANYLP-FLGNPKAYIAAMGPLPTTIHSFLRMVIehktvamvcprspppqsvsaihcppnmrrlpcLTM
  |||..||| . |||.|  |.  |. ..||||||.  . .. |||.|. ||||.|.. | ||.                                  . 
tknryktilPnensrvllesessededssyinanyikGydeeskayvatqGPlpntvadfWrmiy................................qee

FTRQVMTTNFEEKGRKKCECYWPELPQD--TMEFGDIKVFNEGQQQEQFFRITRLRLERGGTIHRVTHFFYNTWPDRGVPRSDDNvmltrgVVKMLAAVR
..  ||.|...|. ..||. |.|.  .   . ..||... .|.  ... .....| |.     ..|.|..|  |||. .|.. ..      ...... |.
vqvivmltklkeaneqkCavyfPdaedyeiserygdveikvekiverndysvrklvlkylerersvkhywytdWPdhksPddant......lldlvleve

RHRIQTDKATSPLLVHCSAGVGRTGCFVLIDQCFRLLEHNQRLDLAALIKENRRYRMAFVQTPEQFEFAWRTVAGYIN
. | .... ..| .||||||.||||||. |. . | |.... .|.  .. . |  |   ||| ||.|. .|... | .
esreeenaklapvvvhCsaGiGrtGcfiaisiavrqlreeivvdvlkivcnlrldrGGmvqtseqyelihralclylk
0039614 (Phosphotyrosine protein) phosphatases II 33-310 3.7e-55 182.9 In-house 57-293 (297) alignment 
Range on Protein: 33-310
Range on HMM: 57-293/297.0
RVYNRYNDILPSPASRVILPEERG-DPATTYINANYLPFLGN-PKAYIAAMGPLPTTIHSFLRMVIEHK--TVAMVCPRSPPPqsvsaihcppnmrrlpc
.  ||| |||| . |||.|  |.| |. ..||||.|...    ....||. |||| |...|.||| |..  .. |...  .                   
kdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfIatqgPlpetvedFwrmvweqgvtvivmLtklvelg.................

ltmftrqvmttnfeekgRkKCECYWPELPQdtmEFGDIKVFNEGQQQEQFFRITRLRLERGGTIHRVTHFFYNTWPDRGVPRSDD-NVMLTRGVVKMLAA
                 | ||. ||||  .   ..||..| . . .... . .. |.....|  . |||| |  ||| ||| | .    . . | . ||.
.................r.kcaqywpeegg...tygdftvtllkvehldgytvrtlevtnngesrtvthfqytgwpdhgvppslellleflelvrealae

VrrhriqtdKATSPLLVHCSAGVGRTGCFVLIDQCFRLLEHNQRLDLAALIKENRRYRMAFVQTPEQFEFAWRTVAGYINFRL
         .   | ||||||||||||.|.... ....||.....|.   .|| |..|.  ||||.|..|  . .. .....|
l........pkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydallellkrkl
0045450 (Phosphotyrosine protein) phosphatases II 34-305 5e-54 179.5 In-house 57-303 (307) alignment 
Range on Protein: 34-305
Range on HMM: 57-303/307.0
VYNRYNDILPSPASRVILPEERGD-PATTYINANYL--------PFLGNPKAYIAAMGPLPTTIHSFLRMVIEHKTVAMVCPRSPPPqsvsaihcppnmr
 .||| |||| . .||.|  . |. . . ||||.|         ..  .....||. |||| |...|.||. |... . |. ... .             
dknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydlkrkfIatqgPlpetvedFwrmlweqgvtvivmltelve.............

rlpcltmftrqvmttnfeeKGRKKCECYWPELpQDTMEFGDIKVFNEGQQQEQFFRITRLRLE---RGGTIHRVTHFFYNTWPDRGVPRsddnvmLTRGV
                   .||.||  |||.  ......|...| . . .... . ...|...     |  ..||||.| .||| |||        .  .
...................lgrekcaqywPde.geeltygnftvtllseehldgytvrtlevtdldgtgesrtvthfhytgwpdhgvpp......sfeel

VKMLAAVRRHRIQtDKATSPLLVHCSAGVGRTGCFVLIDQCFRLLEHNQR---LDLAALIKENRRYRMAFVQTPEQFEFAWRTVAGY
.... .||... . ..  .| ||||||||||||.|.... . |.||...    .||   .|. |. |.  ||.|||..|  . .. .
ldfieevrkalee.lpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyeallel
0045098 (Phosphotyrosine protein) phosphatases II 29-307 1e-50 168.1 In-house 30-273 (278) alignment 
Range on Protein: 29-307
Range on HMM: 30-273/278.0
YARGRVYNRYNDILPSPASRVIlpeergdpatTYINANYLPFLgnPKAYIAAMGPLPTTIHSFLRMVIEHKTVA--MVCPRSPPPqsvsaihcppnmrrl
|  ..  ||| |||| . |||.           ||||.|...   ||..||. ||||.|...|.||. |... .  |...  .                 
ylgnldknRykdilpydhsrVk..........dYINAsyidgy..pkkfIatqgPlpstvadfwrmlwelgitvivmltelvelg...............

pcltmftrqvmttnfeekgRKKCECYWPElpQDTMEFGDIKVFNEGQQQEQFFRITRLRLE------RGGTIHRVTHFFYNTWPDRGVPRSD---DN---
                   |.||. ||||  ......||..| ..  .. . . ...|...       ... . |||. | .||| ||| ..        
...................rekcaqywpe..ggsltygdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflel

VMLTRGVVKMLAAVRRHRIQTDKATSPLLVHCSAGVGRTGCFVLIDQCFRLLehNQRLDLAALIKENRRYRMA-FVQTPEQFEFAWRTVAGYIN
.   | ..| || . .......    | ||||||||||||..|... . .||  ....||   .|| |..|.   ||..||..|  . .. ...
lefirealkllaslllsslllldsggpvlVHCsaGvgRtGtlvaaylmlell..eggvdlleavkelrsqRpglavqnleqyrflyefllelll
0042113 (Phosphotyrosine protein) phosphatases II 34-305 2.4e-50 166.6 In-house 11-242 (245) alignment 
Range on Protein: 34-305
Range on HMM: 11-242/245.0
VYNRYNDILPSPASRVILPEERGDPATTYINANYLPFLGNPKAYIAAMGPLPTTIHSFLRMVIEHktvamvcprspppqsvsaihcppnmrrlpcltMFT
 .||| |||| . .||.|... ||. ..||||.| ..   .. .||. |||| |.. |.||. |.                                  |
dknrysdilpydhtrvklspdggdldsdyinasyvdgyritpkfiatqgPlpetvedfwrmlwel................................git

RQVMTTNFEEKGRKKCECYWPElpQDTMEFGDIKVFNEGQQQEQFFRITRLRLE--RGGTIHRVTHFFYNTWPDRGVPRSddnvmlTRGVVKMLAAVRRH
  || |..||.||.||. |||.  ......||..| . . .... . .. |...  . .  . |.|..|  ||| ||| .      .. ....| .||..
tivmLteeeelgrvkcaqywpl..gesltygdftvtllseehlddytvrtlevtnlgddesrevihyhylpwpdhgvpdl......lellldflefvrka

RIQtdKATSPLLVHCSAGVGRTGCFVLIDQCFRLLEHNQRLDLAALIKENRRYRMAFVQTPEQFEFAWRTVAGY
. .  ..  |.||||||||||||.|.... ....||......|   .|| |..|.  ||||.|..|  . .. .
lae..dsngpvlVHCsaGvgRtGtfiaaylmleqlekelgvsleeavkelrsqRpgavqtpsqyrflyeallel
0050432 (Phosphotyrosine protein) phosphatases II 136-310 8.4e-44 145.5 In-house 137-303 (308) alignment 
Range on Protein: 136-310
Range on HMM: 137-303/308.0
VMTTNFEEKGRKKCECYWPELPQ-DTMEFGDIKVFNEGQQQEQFFRITRLRLER--GGTIHRVTHFFYNTWPDRGVPRSddnvmlTRGVVKMLAAVRRHR
|| |...|.||.||. |||. .. ...|.|...| .  ..... . .. |.|.   .|  ..|||| | .||| ||| |      .. ....| .||...
vmLtklvengrekcaqYwplelgggsleygkftvtllseevlddytvrtleltnlgdgesrtvthfhytnWpdhgvPps......peilldflelvrksl

iqtdkATSPLLVHCSAGVGRTGCFVLIDQCFRLLEHNQRLDLAALIKENRRYRMAFVQTPEQFEFAWRTVAGYINFRL
       .| .|||||||||||.|...| ....||.....|.  ..|  |..|.  ||||||..|  |... |....|
.....pggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtpeqylflyralleylklkl
subfamily_PTPRD_pd Subfamily PTPRD 136-318 3.1e-42 139.9 In-house 120-292 (564) alignment 
Range on Protein: 136-318
Range on HMM: 120-292/564.0
VMTTNFEEKGRKKCECYWPELpQdTMEFGDIKVFNEGQQQEQFFRITRLRL--ERGGTIHRVTHFFYNTWPDRGVPRSDdnvmltRGVVKMLAAVRRHRi
|| |. ||||..||..||||  . | ..|...|  | ... . . |. ..|  ..    . |..| .  |||.||| |       .......  ||... 
VmltkleEkgkvkchkYWPek.g.tetygeltVtleeeeeladyeirtfklkkkkssesreVrqFhFtsWPdhgvpesa......tslLdlirkvraln.

QtdKATSPLLVHCSAGVGRTGCFVLIDQCFRLLEHNQRLDLAALIKENRRYRMAFVQTPEQFEFAWRTVAGYINFrLKTMAQAQA
.  . . |..|||||||||||.|. || . . ..... .|.   .|. |. | | |||.||. | ..... ....  .|  ....
e..pdagPivVhCSaGVGRTGtfividamlerikeektvDiyqyvkalrkqRnamVqteeQYiFiheailealac.gntevesen
subfamily_PTPN12_pd Subfamily PTPN12 136-316 1.9e-41 136.9 In-house 112-287 (290) alignment 
Range on Protein: 136-316
Range on HMM: 112-287/290.0
VMTTNFEEKGRKKCECYWPELPQDTMEFGDIKVFNEGQQQEQ-FFRITRLRLERGGTIHRVTHFFYNTWPDRGVPRSDDNVMltrgvvKMLAAVRRHRIq
||  .  | |.||||.||||  ....|||...| .| ... .  | |  |..|. .. ..|. | |. |||.|||.| ....      .....||...  
vmaCrevelgkkkCerYWpeegeeelefgefevtleeekavdddflirtLkveaqkesrkvyqfhYtaWPDhgvPssaksll......elielvrelqe.

tdKATSPLLVHCSAGVGRTGCFVLIDQCFRLLEHNQR---LDLAALIKENRRYRMAFVQTPEQFEFAWRTVAGYINFRLKTMAQA
  .  .||.|||||||||||  . ||   .||....    ||.  |. | |. | | ||| ||.|. ...|| ... .|... . 
..sedaPlvvhCsaGvGrtGtiiaidyvrellkaekipeeldvfdlvlelrkqraalvqtkeqyelvykavaelvqkeleiieek
0040438 (Phosphotyrosine protein) phosphatases II 136-310 5.2e-41 136.3 In-house 115-280 (317) alignment 
Range on Protein: 136-310
Range on HMM: 115-280/317.0
VMTTNFEEKGRKKCECYWPElpQDTMEFGDIKVFNEGQQQEQFFRITRLRLE--RGGTIHRVTHFFYNTWPDRGVPRsddnvmLTRGVVKMLAAVRRHRi
|| |..||.||.||. |||.  ..|...||..| . . .... . ...|..|  .... ..|||| | .||| |||        .. ....| |||... 
vmLteleelgrekcaqYwpl..getltygdftvtllseeelagitlrtlevedlgdsesrtvthfhytgWpdhgvpp......spdllldfleavreal.

QtdKATSPLLVHCSAGVGRTGCFVLIDQCFRLLEHNQRLDLAALIKENRRYRMAFVQTPEQFEFAWRTVAGYINFRL
.  .  .|.||||||||||||.|.... ....||.....|.   .|| |..|.  ||||||..|  . .. |....|
e..dpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalleylkrkl
0036941 (Phosphotyrosine protein) phosphatases II 136-310 5.3e-41 136.3 In-house 107-281 (297) alignment 
Range on Protein: 136-310
Range on HMM: 107-281/297.0
VMTTNFEEKGRKKCECYWPELPQDTMEFGDIKVFNEGQQQ--EQFFRITRLRLER--GGTIHRVTHFFYNTWPDRGVPRsddnvmLTRGVVKMLAAVRRH
|| |...|.||.||. |||.  ......||..|.. . ..  .. . .. |...   .|  ..|||| | .||| |||        .. ..... .||..
vmltelvelgrekcaqywpleegesltygdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpe......spaslldfielvrkv

RiQTDKATSPLLVHCSAGVGRTGCFVLIDQCFRLLE---HNQRLDLAALIKENRRYRMAFVQTPEQFEFAWRTVAGYINFRL
. .     .| ||||||||||.|.|...| ....||   .....|.  ..|. |..|.  |||.||..|  .... .....|
l.kllpsggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallellkkkl
subfamily_PTPRB_pd Subfamily PTPRB 136-305 5.6e-40 132.2 In-house 123-284 (293) alignment 
Range on Protein: 136-305
Range on HMM: 123-284/293.0
VMTTNFEEKGRKKCECYWPELPQdTMEFGDIKVFNEGQQQEQFFRITRLRLERGGTIHRVTHFFYNTWPDRGVPRSddnvmlTRGVVKMLAAVRrHRIQT
|| |.  |||..||| |||.  . .. .|||||    ... . . |  |..|.. ....|... . .||| ||| .      |. ..... .|| ..|..
vmltqlvekgkvkCeeYWPadee.pvlyGdikvtlvaeeeledwvirelkiekekeerkvrqyhftsWpdhgvPek......tktlldfvrtvr.eaiek

DKATSPLLVHCSAGVGRTGCFVLIDQCFRLLEHNQRLDLAALIKENRRYRMAFVQTPEQFEFAWRTVAGY
.....|..||||||||||| |. .|. .. .|... .|..... | |. |. .||| .|. |  ..|  .
taskrPivvhCsaGvGRtGtfialdrllqaieeedyvdifgivaelReeRnllvqtekqYifihqcvldl
0047943 (Phosphotyrosine protein) phosphatases II 136-306 1.9e-39 131.2 In-house 106-272 (273) alignment 
Range on Protein: 136-306
Range on HMM: 106-272/273.0
VMTTNFEEKGRKKCECYWPELPQD-TMEFGDIKVFNEGQQQEQFFRITRLRLER--GGTIHRVTHFFYNTWPDRGVPRSDDNVM-LTRGVVKMLAAVRRH
|| |...|.||.||. |||.  .. ....|...| . ...... . .. |.|..   |  . |||| | .||| ||| | . .. . . | |.|.|....
VmLtelvelgrekcaqYwpleggelsltygkftvtllseetkddytvrtleltnlgtgesrtvthfhytgwpdhgvppslesllefielvrkalealpsn

riqtdkatSPLLVHCSAGVGRTGCFVLIDQCFRLLEHNQRLDLAALIKENRRYRMAFVQTPEQFEFAWRTVAGYI
        .| .|||||||||||.|...| ....||.....|.  ..|  |..|.  ||||||..|  .... |.
........gpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrflyealleyl
DSPc_SM00195 136-306 3.8e-39 129.9 In-house 98-262 (263) alignment 
Range on Protein: 136-306
Range on HMM: 98-262/263.0
VMTTNFEEKGRKKCECYWPELPQDTMEFGDIKVFNEGQQQEQ-FFRITRLRLERGG--TIHRVTHFFYNTWPDRGVPRSddnvmlTRGVVKMLAAVRRHR
||.|..||.|..||. ||||  .....||.|.| .  .....  . .. |.|.  |  . ..||.. |..|||.||| |      |. |...| ||. ..
vmlteeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpds......tksvlellravkksk

IQTdkaTSPLLVHCSAGVGRTGCFVLIDQCFRLLEHNQRLDLAALIKENRRYRMAFVQTPEQFEFAWRTVAGYI
 ..   ..|..|||||||||||.||.|| . . ||.....|. ...|| |  |.  ||| ||. |. .... ||
sts...sgpivVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi
PTPc_SM00194 136-306 3.8e-39 129.9 In-house 98-262 (263) alignment 
Range on Protein: 136-306
Range on HMM: 98-262/263.0
VMTTNFEEKGRKKCECYWPELPQDTMEFGDIKVFNEGQQQEQ-FFRITRLRLERGG--TIHRVTHFFYNTWPDRGVPRSddnvmlTRGVVKMLAAVRRHR
||.|..||.|..||. ||||  .....||.|.| .  .....  . .. |.|.  |  . ..||.. |..|||.||| |      |. |...| ||. ..
vmlteeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpds......tksvlellravkksk

IQTdkaTSPLLVHCSAGVGRTGCFVLIDQCFRLLEHNQRLDLAALIKENRRYRMAFVQTPEQFEFAWRTVAGYI
 ..   ..|..|||||||||||.||.|| . . ||.....|. ...|| |  |.  ||| ||. |. .... ||
sts...sgpivVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi
Y_phosphatase Protein-tyrosine phosphatase 136-302 2.1e-38 127.4 Pfam-A 71-233 (235) alignment 
Range on Protein: 136-302
Range on HMM: 71-233/235.0
VMTTNFEEKGRKKCECYWPELPQDTMEFGDIKVFNE-GQQ-QEQFFRITRLRLERGGTIH---RVTHFFYNTWPDRGVPRSddnvmlTRGVVKMLAAVRR
|| |. |||||.||. ||||  ......||||| ..  .. .|. . .. |.|.  .. .   .|... |..|||.|||.|      ........ .|..
vmltsleekgrekcaqYwpeeeeesltygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpes......pkslldlirkvek

HRiqtDKATSPLLVHCSAGVGRTGCFVLIDQCFRLLEHNQRLDLAALIKENRRYRMAFVQTPEQFEFAWRTV
..   .. ..|..|||||||||||.||..| ... ||... .|.  ..|| |. |.  ||. ||..|  ...
sk...eaksgpvvVhCsaGvgRtgtfvaldilleqleaeeevdvlqivkelRkqRpgmvqsleqYiflykai
Y_phosphatase Protein-tyrosine phosphatase 136-302 2.1e-38 127.4 In-house 71-233 (235) alignment 
Range on Protein: 136-302
Range on HMM: 71-233/235.0
VMTTNFEEKGRKKCECYWPELPQDTMEFGDIKVFNE-GQQ-QEQFFRITRLRLERGGTIH---RVTHFFYNTWPDRGVPRSddnvmlTRGVVKMLAAVRR
|| |. |||||.||. ||||  ......||||| ..  .. .|. . .. |.|.  .. .   .|... |..|||.|||.|      ........ .|..
vmltsleekgrekcaqYwpeeeeesltygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpes......pkslldlirkvek

HRiqtDKATSPLLVHCSAGVGRTGCFVLIDQCFRLLEHNQRLDLAALIKENRRYRMAFVQTPEQFEFAWRTV
..   .. ..|..|||||||||||.||..| ... ||... .|.  ..|| |. |.  ||. ||..|  ...
sk...eaksgpvvVhCsaGvgRtgtfvaldilleqleaeeevdvlqivkelRkqRpgmvqsleqYiflykai
0043336 (Phosphotyrosine protein) phosphatases II 136-305 5.4e-38 126.4 In-house 117-276 (278) alignment 
Range on Protein: 136-305
Range on HMM: 117-276/278.0
VMTTNFEEKGRKKCECYWPelpQDTMEFGDIKVFNEGQQQEQFFRITRLRLE--RGGTIHRVTHFFYNTWPDRGVPRSDDNVmltrgvVKMLAAVRRHRI
|| |...|.||.||  |||   ......||..| . ...... . .. |...  . |  . |||. |  ||| ||| | . .      ...| |||... 
vmLtelvelgrvkcaqYwp...ggsltygdftvtllkeehlddytvrtlevtnlgdgesrtvthyhylgwpdhgvpeslsll......ldflkavreale

qtdKATSPLLVHCSAGVGRTGCFVLIDQCFRLLEHNQRLDLAALIKENRRYRMAFVQTPEQFEFAWRTVAGY
   .  .|.||||||||||||.|.... ....||.....||   .|| |..|.  ||||.|..|  . .. |
...dsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflyealley
subfamily_PTPN9_pd Subfamily PTPN9 136-306 2e-37 123.9 In-house 114-290 (297) alignment 
Range on Protein: 136-306
Range on HMM: 114-290/297.0
VMTTNFEEKGRKKCECYWPELPQDTMEFGDIKVFNEGQQQEQFFRITRLRLE--RGGTIHRVTHFFYNTWPDRGVPRSDDNVMLTRGVVKMLAAVRRHRI
|||| ..|.|| ||  |||.  ....||||..| |  ...|. .... | ..  . . . .|||| . .||| |||.|  ...  . .|.   |.  . .
vmttrvvergrlkcgqyWpleeessaefgdlsvsnveveeeedykvrvleiknvkteesrkvthfqflsWPdyGvPssaaslldvlekvrekqalavkel

Q----TDKATSPLLVHCSAGVGRTGCFVLIDQCFRLLEHNQRLDLAALIKENRRYRMAFVQTPEQFEFAWRTVAGYI
      .    |..||||||.|||| |. .| |   ||. . .|.   .|  |  |   .|||||.|| . .|  | 
gdewkghpsgPPivvhcsaGiGrtGtfitldiclsrleevgtvdvvetvkllrtqrafsiqtpeqyefcylavleya
subfamily_PTPN6_pd Subfamily PTPN6 136-311 4.7e-37 122.6 In-house 127-302 (306) alignment 
Range on Protein: 136-311
Range on HMM: 127-302/306.0
VMTTNFEEKGRKKCECYWPELPQDTMeFGDIKVFNEGQQQEQFFRITRLRL---ERGGTIHRVTHFFYNTWPDRGVPRSDDNVMltrgvvKMLAAVRRHR
||||.  |.|..||  |||.  .... .|.|.| |  ... . . . .|..   ..... ..| .. ...||| |||.. . |.      ..|  |.|..
vmttkevErgkekCarYWPdeeekee.yGkisvtnvseksladYilRelsvskkkkkkeerevfqyhfksWPdhgvpkdpgavL......dfledvnrkq

IQTD-KATSPLLVHCSAGVGRTGCFVLIDQCFRLLEHN---QRLDLAALIKENRRYRMAFVQTPEQFEFAWRTVAGYINFRLK
 ..  . . |..||||||.|||| |..||   .|.|..     .|.  |.|  |..|  .||| .|. | ..... ||. . |
eeleeaeagpivvhCsaGiGRtGtfiviDillkliekkgldadidiqklvksvreqrsglvqteqqykfvykaikkyietkkk
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 136-310 2.5e-36 120.3 In-house 113-280 (281) alignment 
Range on Protein: 136-310
Range on HMM: 113-280/281.0
VMTTNFEEKGRKKCECYWPElPQDTMEFGDIKVFNEGQQQEQFFRITRLRL-ERGGTIHRVTHFFYNTWPDRGVPRSDDNVMLTRgvvkmlAAVRRHriQ
|| |.  |.|. ||  |||. .. ....||..| .. ..... .   ...| ...|   .|... | .||| ||| .  ...  |      ..|..   .
vmvtreieagklkChrYWPd.dnselkygdvtvkstaeeekatyierkfkleresgetreveqlaytaWPdhGvPattkellefr......kevlkl..t

TDKATSPLLVHCSAGVGRTGCFVLIDQCFRLLEHN-QRLDLAALIKENRRYRMAFVQTPEQFEFAWRTVAGYINFRL
. |   ||..||||||||||... .|. .. .|.. ..||. |...| |. |. .|||  |.|| ...|  ...  |
ekktkaplvihCsaGvGrtGtyialDrlvkaveaeleeldvkavvaelrkernlmvqtvvqyefvykavldaldkel
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 36-302 2.9e-36 120.4 In-house 65-287 (319) alignment 
Range on Protein: 36-302
Range on HMM: 65-287/319.0
NRYNDILPSPASRVILPEERGDPATTYINANYLPFLGNPKAYIAAMGPLPTTIHSFLRMVIEHKTVAMVCPRspppqsvsaihcppnmrrlpcltmftrq
||. .||.   ..| |    |   . |||| ..    ... |||| |||. |.  | ||. |... ..|                               
nriinilafdknvvklerliGeefsdyinasfvtGyqrkdkyiaaqGPldntladfWrmiweyncstivllt............................

vmttnfeekgRKKCECYWPELPQDTMEFGDIKVFNEGQQQEqfFRITRLRLER---GGTIHRVTHFFYNTWPDRGVPRSDDNVMLtrgVVKMLaavrRHR
          ..||  |||   . . | ...||    . .|  . .  ..| .      | ..| | .  ||| ||| .  ..|    .|| .    || 
..........kdkcsqywplkivikeerfkvkvdsveetae..yvvrdielsedgkekdirkitqfhflGwpdvGvpdypsdlmr...lvkkv....rhl

IQTDKATSPLLVHCSAGVGRTGCFVLIDQCFRLLEHNQRLDLAALIKENRRYRMAFVQTPEQFEFAWRTV
 .  .   ...||||||||||| .. .|  .  .......|.  .... |. |  .||   |. | . ..
tskenhranivvhcsaGvGrtGvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysal
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 35-302 6.4e-36 119.3 In-house 28-251 (284) alignment 
Range on Protein: 35-302
Range on HMM: 28-251/284.0
YNRYNDILPSPASRVILPEERGDPATTYINANYLPFLGNPKAYIAAMGPLPTTIHSFLRMVIEHKTVAMVCPRspppqsvsaihcppnmrrlpcltmftr
 ||. .||.   ..| |    |   . |||| ..    ... |||. |||. |.  | ||. |... ..|                              
knrighilafdknvvklerliGeefsdyinasfitGyqrkdkyiatqGPldntladfWrmiweyncstivllt...........................

qvmttnfeekgRKKCECYWPELPQDTMEFGDIKVFNEGQQQEqfFRITRLRLER---GGTIHRVTHFFYNTWPDRGVPRSDDNVMLtrgVVKMLaavrRH
           ..||  |||   . . | ...||    . .|  . .  ..| .      | ... | .  ||| ||| .  ..|    .|| .    ||
...........kdkcsqywplkivikeerfkvkvdsveesee..yvvrdielsedgkekdirkirqfhflgwpdvgvpdypsdlmr...lvkkv....rh

RIQTDKATSPLLVHCSAGVGRTGCFVLIDQCFRLLEHNQRLDLAALIKENRRYRMAFVQTPEQFEFAWRTV
  .  .  ....||||||||||| .. .|  .  .......|.  .... |. |  .||   |. | . ..
ltskenhranivvhcsagvgrtgvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysal
0040439 (Phosphotyrosine protein) phosphatases II 136-305 8.4e-36 119.2 In-house 83-245 (249) alignment 
Range on Protein: 136-305
Range on HMM: 83-245/249.0
VMTTNFEEKGRKKCECYWPElpQDTMEFGDIKVFNEGQQQEQFFRITRLRLE--RGGTIHRVTHFFYNTWPDRGVPRSDDNvmltrgVVKMLAAVRRhRI
|| |...|.||.||. |||.  ....|.||..| .   .... . .. |.|.    |. ..|.|. |  ||| ||| | .       ..... |||   .
vmLtslvelgrekcaqywpl..ggsleygdftvtllsvevkddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfed......lldfieavrk.al

QTDKATSPLLVHCSAGVGRTGCFVLIDQCFRLLEHNQRLDLAALIKENRRYRMAFVQTPEQFEFAWRTVAGY
....  .|.||||||||||||.|.... ....||.....||   .|. |..|.  ||.|||..|  . .. .
eelpkggpvlVHCsaGvgRtGtfiaaylmleqlekelgvdleeavkllrsqRpgavqnpeqyrflyeallel
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 136-305 2e-35 117.3 In-house 119-278 (288) alignment 
Range on Protein: 136-305
Range on HMM: 119-278/288.0
VMTTNFEEKGRKKCECYWPELpQDTMEFGDIKVFNEGQQQEQFFRITRLRLERGGTIHRVTHFFYNTWPDRGVPRSDDNVMLTRGVVKMLAAVRrhriqt
|| |.. |.|..||| |||.  ..  ..|...|   ...... |   .| ||. .|  ..|.. | .||| |||.|  ...  .  ||.           
vmltelveggktkCeeYWPda.dkpknyGsvtvtlveskeledfvlrklllekkkteleitqyqylaWpdhgvPeskapllellrqvkvanqad......

dkaTSPLLVHCSAGVGRTGCFVLIDQCFRLLEHNQRLDLAALIKENRRYRMAFVQTPEQFEFAWRTVAGY
   | |..||||||||||| |. .|.    .|... .|.|. ... |. |. .||| .|.|| .....  
...tgpiivhCsaGvGrtgtFialdalidaveeedyiDvagtvaklRkqRallvqtlkqYefiyevllsl
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 35-306 4.1e-34 113.2 In-house 51-288 (325) alignment 
Range on Protein: 35-306
Range on HMM: 51-288/325.0
YNRYNDILPSPASRVILPEERGDPATTYINANYLPFLGNPKAYIAAMGPLPTTIHSFLRMVIEHKtvamvcprspppqsvsaihcppnmrrlpcltmfTR
 ||......   |||.|   . || . ||||.||    . . ..||  ||..||. . |.|.. .                                 . 
knrfknvvaldksrvvletkkddpssdyinasylrddkkkdvflaaqaPltatindlWrlvldWr.................................cs

QVMTTNFEEKGRKKCECYWPELPQDTMEFGDIKVFNE--GQQQEQFFRITRLRLERGGTIHRVTHFFYNTWPDRGVPRSDDNVMLtrgVVKMLAAVRrHR
 |. .|  ..| ..|  |||.   .. .|| ..|      .  .   |.  ..  ..|    |  | . .|.| ||..    ..    ..... ||   |
vvvvlneldlgkdrcavywpkemgksktfGglevklrtieeisdyvhrvldvkqvkkGetrsvkqfqlqswddmGvqkrpatlis...ilqlvkavs.er

IQT-DKATSPLLVHCSAGVGRTGCFVLIDQCFRLLEHNQRLDLAALIKENRRYRMAFVQTPEQFEFAWRTVAGYI
...  ||..|.|||||||||||| |. .      . .. |.|.   .|  |. | . |.| .|. . . ... ..
vtantkastpilvhcsaGvGrtGvfislysalakvieesrvdifgfvkklrkdrpsmvetvdqyiliyealveay
0051429 (Phosphotyrosine protein) phosphatases II 59-309 5.8e-34 113.4 In-house 3-228 (272) alignment 
Range on Protein: 59-309
Range on HMM: 3-228/272.0
ATTYINANYLPFLGN---PKAYIAAMGPLPTTIHSFLRMvIEHKtvamvcprspppqsvsaihcppnmrrlpcltmFTRQVMTTNFEEKGRKKCECYWP-
 ..||||.... .|.   |...... |||| |...| |.  |..                                 .  |. .. ||.|| ||..||| 
lsgyiNardvggygrvvkpgrlyrsggplpltaadfwrl.kelg................................iktivdLrseeErgrlkcdrywpg

---------ELPQDTMEFGDIKVFNEGQQQEQFFRITRLRLE---RGGTIHRVTHFFYNTWPDRGVPRSDdnvmltrgVVKMLAAVRRhriqtdkaTSPL
         .    |...|.. |..   ..  .. ...|.|.     |....|.|..|  |||.|||..         ....|.....          |.
irylhlpilddsaptilygalrvtllseellldyilrellltlllsagearevmhlhytdwpdhgvpqea........llellellld........ggpv

LVHCSAGVGRTGCFVLIDQCFRLLEHNQRLD--------LAALIKENRRYRMAFVQTPEQFEFAWRTVAGYINFR
|||||||..|||..|... . . ..... .|        |.. ..| |..|...|||.||..| .. .. ...  
lvHCsaGkdRTGtvvallllllgvsletivddYlltnlyleeaveelraqrpgavqteeqylflyeallellrsl
subfamily_PTPN3_pd Subfamily PTPN3 136-301 6.5e-34 112.1 In-house 113-270 (280) alignment 
Range on Protein: 136-301
Range on HMM: 113-270/280.0
VMTTNFEEKGRKKCECYWPElPQDTMEFGDIKVFNEGQQQEQFFRITRLRL--ERGGTIHRVTHFFYNTWPDRGVPRSDDNvMLtrgvvKMLAAVRRHRi
|| |.  |.||.||  |||| ..|..|.|...|  | ..... . .  | |  ..    ...... |  ||| ||| . .. .|     ...  ||. | 
vmlttlverGrvkChqyWPe.tedeleygefsvkcekedetksyvlrelvlkdketkeerkilqlqylaWpdhgvPddsad.fl.....efvervrklr.

qtDKATSPLLVHCSAGVGRTGCFVLIDQCFRLLEHNQRLDLAALIKENRRYRMAFVQTPEQFEFAWRT
    ...|..||||||.|||| ..|.. .. |.|... .   ..... |  |...|||..|..|   .
..sgkeePvvvhCsaGigrtGvlilletalalieaaepvypldivrtmrdqramlvqtasqykfvCea
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 134-309 2.2e-33 110.2 In-house 113-279 (515) alignment 
Range on Protein: 134-309
Range on HMM: 113-279/515.0
RQVMTTNFEEKGRKKCECYWPELPQDTMEFGDIKVFNEGQQQEQFFRITRLRLERGGTIHRVTHFFYNTWPDRGVPRSddnvmlTRGVVKMLAAVRRhri
  .| |. .|  . ||  |||. | |...|| |||     .      . .|.. .|  .. || | .. |||.|||.       |. ..|.. .|.    
tiamvtklkegdkikcgkyWPdkpgdsvkfGsikvelvsleactggikrkltvlkgddsrtvtqfhfteWPdkGvpkh......tssllklikevka...

QTDKATSPLLVHCSAGVGRTGCFVLIDQCFRLLEHNQRLDLAALIKENRRYRMAFVQTPEQFEFAWRTVAGYINFR
.... | ||..|||||||||| .. ||..    .  . .|.  ...  |. |. .||| ||. | . .|  .. .|
dhgqythpliihcsaGvGrtGvvisidsvvahakttrmvdvfnfvtnirqkrpylvqtqeqyafiygavledllwr
0037934 (Phosphotyrosine protein) phosphatases II 136-302 2.6e-33 111.0 In-house 77-238 (243) alignment 
Range on Protein: 136-302
Range on HMM: 77-238/243.0
VMTTNFEEKGRKKCECYWPelpqDTMEFGDIKVFNEGQQQEQFFRITRLRLER---GGTIHRVTHFFYNTWPDRGVPRSDDNVMltrgvvKMLAAVRRHR
|| |...|.||.||. |||    .....||..| . .... . . .. |.||.   ..  . |.|. |  ||| ||| | ....      ..| .|| . 
vmltelvElgrekcaqywp....gevtygdftvtllseehlddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedll......dfldevrefi

IQ-----TDKATSPLLVHCSAGVGRTGCFVLIDQCFRLLehnqRLDLAALIKENRRYRMA-FVQTPEQFEFAWRTV
 .     ...  .|.||||||||||||...... . .||    ..||   .|. |. |.   ||||.|..|  . .
eellsllaldsggpvlVHCsaGvgRtGtliaaylmllll....gvdleeavkllreqRpgkavqtpsqyrflyeal
subfamily_PTPN13_pd Subfamily PTPN13 136-302 3.2e-32 106.9 In-house 106-265 (273) alignment 
Range on Protein: 136-302
Range on HMM: 106-265/273.0
VMTTNFEEKGRKKCECYWPELPQDTMEFGD-IKVFNEGQQQEQFFRITRLRLER--GGTIHRVTHFFYNTWPDRGVPRSDDNVmltrgvVKMLAAVRRhr
.| |.  |||. ||. ||||  ....   . ..| ....|. . | . .| ..    |  ..|.|. . .||| |||.| ...      ....| |||  
amvtlekekgkvkchrywPesknkklkvsnrlevellkvqkldgfvvralavkdsesgesrevahlnfvkwPdhgvPssaael......lqfvaevrr..

IQTDKatSPLLVHCSAGVGRTGCFVLIDQCFRLLEHNQRLDLAALIKENRRYRMAFVQTPEQFEFAWRTV
.|||.  .|..||||||.||.| .. ||  . |.|... .|.  .... |. | . ||| .|. | ....
lqtda..gPivvhcsaGiGrsGtlitidvvlglierdkefdvkeivrklreqrqgvvqtkdqyifvykai
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 136-308 1.3e-31 104.9 In-house 118-282 (318) alignment 
Range on Protein: 136-308
Range on HMM: 118-282/318.0
VMTTNFEEKGRKKCECYWPElpQDTMEFGDIKVFNEGQQQEQFFRITRLRLER--GGTIHRVTHFFYNTWPDRGVPRSDdnvmltRGVVKMLAAVRrhRI
|| |. ||.|..|.. |||.  ......|...|  . . . . . . .....|        |  . | .|||.||| |        ......  |.  ..
vmltqeeergkakvhryWPs..kgsrsygklvvelkeevelsdyvlrefkvtrteeeesrqvrqyhytsWpdegvpesg......aslldlvrqvs..ka

QTDKATSPLLVHCSAGVGRTGCFVLIDQCFRLLEHNQRLDLAALIKENRRYRMAFVQTPEQFEFAWRTVAGYINF
|... ..|..||||||||||| |. .|   . ..... .|.   .|. |. | . ||| .|.|| . ..  ... 
qqksgagpivvhCsaGvGrtGvfiavdillerikaealvDvfqtvkqlreqrnlmvqtedqyefiydvllealas
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 135-310 1.9e-31 104.1 In-house 115-281 (315) alignment 
Range on Protein: 135-310
Range on HMM: 115-281/315.0
QVMTTNFEEKGRKKCECYWPELPQDTMEFGDIKVFNEGQQQEQFFRITRLRLERGGTIHRVTHFFYNTWPDRGVPRSDDnvmltrGVVKMLAAVRRHriq
 || |. .|  . ||  |||.   |..||| |||     ..     . .| . .. . ..|| | .. |||.||..          ..|.. .|.     
ivmvtkkqegdkikcrqywPdrkadsvefGsikvellsleadtdgvarklvtrkseesrtvtqfqftewPdkGvdkqts......sllklikevkad...

TDKATSPLLVHCSAGVGRTGCFVLIDQCFRLLEHNQRLDLAALIKENRRYRMAFVQTPEQFEFAWRTVAGYINFRL
 .| . .||||||||||||| .. ||..   ..... .|.  ..|. |. |. .||| |.. | . .|  .. .| 
ngkkefsllvhcsaGvGrtGvvisidevvaqikrtrsvdvfnfvknlrakrpylvqteeeyafiydavledllwrn
subfamily_PTPN14_pd Subfamily PTPN14 136-307 3e-31 103.5 In-house 122-297 (300) alignment 
Range on Protein: 136-307
Range on HMM: 122-297/300.0
VMTTNFEEKGRKKCECYWPEL--PQDTMEFGDIKVFNEGQQQEQFFRITRLRLERG--GTIHRVTHFFYNTWPDRGVPRsDDNVMLTrgVVKMLAAVRRH
|| |. ||.|..|.  |.|.|   ..|.|||  || .. ... . .  | |.|.    .    | |. |. |||.|||. | . .|    .... .|||.
vmlteeeedgkeksfkyfPkleskkktvefgkfkvttkfsedsdsvittglklkhlpskeertvwhlqytDWpdhgvPe.Dvkgfls..yLeevqsvrrk

RIQTD---KATSPLLVHCSAGVGRTGCFVLIDQCFRLLEHNQRLDLAALIKENRRYRMAFVQTPEQFEFAWRTVAGYIN
  ..    ..  |.||||||||||||  .| |     ||||...|.   ..  |. || .|||  |..| ....  |..
tnseveskeskPPvlvhCsaGvGrtGvlilsdlliatlehneeidikkvlarLreqrmllvqtlaqYkfvYkvlikylk
subfamily_PTPRA_pd Subfamily PTPRA 136-306 4.1e-31 103.1 In-house 130-295 (330) alignment 
Range on Protein: 136-306
Range on HMM: 130-295/330.0
VMTTNFEEKGRKKCECYWPElpQDTMEFGDIKVFNEGQQQEQFFRITRLRLERGG------TIHRVTHFFYNTWPDRGVPRSddnvmlTRGVVKMLAAVR
|| |...|. ..||. |||.  . .. .|.|.|  | ..  . . .  . ... .      .   |. | ...||| |||        ..|..|.|..|.
vmltelkerkeekcaqywPd..eGlvtyGnirvevedetvlvdytvrkflvqqlpdatrekksrlvrqfhftswPdvGvPfe......piGmlkllkkvk

RHRIQTdkATsPLLVHCSAGVGRTGCFVLIDQCFRLLEHNQRLDLAALIKENRRYRMAFVQTPEQFEFAWRTVAGYI
. . |.  |  |. ||||||||||| |. .|. .  .. ....|.   .|. |  |   ||| ||.|| ....  | 
klnqqs..ag.pivvhcsaGvGrtGtfivldavlervkaerkvdvfefvkrlrlqrpqmvqtdeqyefiykvlleyy
subfamily_PTPN1_pd Subfamily PTPN1 136-302 4.7e-31 102.6 In-house 100-267 (290) alignment 
Range on Protein: 136-302
Range on HMM: 100-267/290.0
VMTTNFEEKGRKKCECYWPELPQ-DTMEFG--DIKVFNEGQQQEQFFRITRLRLER--GGTIHRVTHFFYNTWPDRGVPRSDDNVMltrgvvKMLAAVRR
||  .. ||.. ||  |||.  . .....    .||    .........  |.||       . ..|| | |||| |||.|  . .      |.|  ||.
vmlnkvvekeqikcaqywPqgeeekellledtklkvkliseerksyytvrllelenlktqetreilhfhyttwpdfgvpespaafl......kflfkvre

HRIQTDkATSPLLVHCSAGVGRTGCFVLIDQCFRLLEHNQR---LDLAALIKENRRYRMAFVQTPEQFEFAWRTV
    ..    | ..|||||.||.| |.|.| |. |.|...    .|.   . | |.||. ..||..|..|.. ..
sGslss.dvGpavihcsaGiGrsGtfclvdtclvliekkddlssvdikkvllelrkyrlGliqtadqlrfsylai
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 136-307 1.6e-30 101.3 In-house 118-284 (305) alignment 
Range on Protein: 136-307
Range on HMM: 118-284/305.0
VMTTNFEEKGRKKCECYWPELPQDTMEFGDIKVFNEGQQQEQFFRITRLRLER---GGTIHRVTHFFYNTWPDRGVPRSddnvmlTRGVVKMLAAVRRHR
|| |.  | |..||. ||||  ....|||...|  . ... . . . .|..         . |...   .||| |||..      .  .....  |....
vmltklveggkdkCrqYWpesktekkefgefsvelksektasdyieRklkisiededkesrtvlqyqltdWPdhGvpqf......atsllslikrvqkdq

iQTDKaTSPLLVHCSAGVGRTGCFVLIDQCFRLLEHNQRLDLAALIKENRRYRMAFVQTPEQFEFAWRTVAGYIN
 . ||   |||||||||||||| |. .|  .  |.. . .|.. ..|. |. ||  ||| .|. | .  .. .|.
.kkdk.gvpllVhCsagvgRtGvfiavdialerlkkEevvdvfevlkqlRskrmkmvqtldqYvflhdaldelit
0041856 (Phosphotyrosine protein) phosphatases II 35-308 2.2e-30 101.0 In-house 4-173 (182) alignment 
Range on Protein: 35-308
Range on HMM: 4-173/182.0
YNRYNDILPSPASRvilpeergdpATTYINANYLPFLGNPKAYIAAMGPLPTTIHSFLRMVIEHKT--VAMVCprspppqsvsaihcppnmrrlpcltmf
.||| |||| . ||            .|||||.. .   .. .||. |||. |. .||||. |..   . ...                           
knrysdilpydhsr..........dldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt...........................

trqvmttnfeekgrkkCECYWPELPqdtmefgdikvfnegqqqeqffritrlrlerggtIHRVTHFFYNTWPDRGVPRsddnvmlTRGVVKMLAAVRRhr
                .|.|||||                                    . .....|  ||| |||        .. ..... .|..  
................eelywpell..................................erlgiqylylpwpDhgvpd.......ldelldfieevle..

iqtdkATSPLLVHCSAGVGRTGCFVLIDqcfrLLEHNqRLDLAALIKENRRYRMAFVQTPEQFEFAWRTVAGYINF
        | ||||||||||||..|...    |.... ...|   .|. |..|.  |.||.|. |  . .  .. .
.....eggpvlVHCsaGvgRtgtlvaay....lmkkl.gvsleeavklvrsrRpgmvitpnqyfflqlallellll
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 136-306 5.7e-30 99.5 In-house 121-284 (297) alignment 
Range on Protein: 136-306
Range on HMM: 121-284/297.0
VMTTNFeEKGRKKCECYWPELPQDTmeFGDIKVFNEGQQQEQFFRITRLRLERGG--TIHRVTHFFYNTWPDRGVPRSDDNVMLtrgvVKMLAAVRRHRI
|| ..  ... |||  ||..    |  |||. |  .  .. . |    | ...|   . . |  . .  |||. |.| |.  .|    .|..  || .  
vmlndd.nerdkkcaryWsdkgvtt..fGdvsvvllsvsereGfikrelevtkgkakarrvvkqyqfveWPdkaverkdsassl....lklisevrkdfs

QtdKATSPLLVHCSAGVGRTGCFVLIDQCFRLLEHNQRLDLAALIKENRRYRMAFVQTPEQFEFAWRTVAGYI
|  .| .||||||.||||||| .. ||..    .... .|.  |.|  |. |. .||| ||..| . .|  ..
q..naegPllvhclaGvGrtgvlltidsvvaeakrekevdifglvkklrqerpylvqtkeqykfvyvavleal
subfamily_Ptp69D_pd Subfamily Ptp69D 136-309 5.8e-30 99.5 In-house 120-289 (307) alignment 
Range on Protein: 136-309
Range on HMM: 120-289/307.0
VMTTNFEEKGRKKCECYWP-ElpqDTMEFGDIKVFNEGQQQEQFFRITRLRLERGG-------TIHRVTHFFYNTWPDRGVPRSddnvmlTRGVVKMLAA
|| .| .|| ||||. ||| |   |....||| |    ... . . |  | . . .         ..|. . |..|.|  ||..      .||..|..  
vmlsnlteknrkkcakYWpie...devqygdilvklvseekhsdyiiReldvskkkeesgevedsrkvvqyhytgWkDskvPev......argllklieq

VRRHRIQTdkaTSPLLVHCSAGVGRTGCFVLIDQCFRLLEHNQRLDLAALIKENRRYRMAFVQTPEQFEFAWRTVAGYINFR
|| .  .     ||..|||||||||.| || .|  .  |. ....|. . .|. |. |  .||  ||..| .| .. |... 
vrelykln...rsPivvhCsaGvgrsgifvaldsllqqlkaedkvdifetvkdLrsqRnllvqsleqYvflyralldyssyg
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 136-306 8.6e-30 99.0 In-house 128-290 (298) alignment 
Range on Protein: 136-306
Range on HMM: 128-290/298.0
VMTTNFEEKGRKKCECYWPElpQDTMEFGDIKVFNEGQQQEQFFRITRLRLE--RGGTIHRVTHFFYNTWPDRGVPRSddnvmlTRGVVKMLAAVRRhrI
|| || ||... |.. |||.  . . ..|.|.|    ...   . ...| ..  .  . ..| .. . .|||.|||.       .. |...|. ||.   
VmltnleeldktkyhkywPd..egketygeitvsllskeefadlivrklkvskkkeekerevrqlhftsWpdkgvpen......atsvldllrkvra..s

QTDKATSPLLVHCSAGVGRTGCFVLIDQCFRLLEHNQRLDLAALIKENRRYRMAFVQTPEQFEFAWRTVAGYI
|..   .|..|.|||||||.| |. ||  .  ....| .|.   .|  |. |.. ||| ||. | .  |  ..
qqqagnkpvivqCsaGvgRsGtfiaidsvlervkkeqvvDvfqvvkvlRkkrpgavqteeqYvfiyeavleal
0049772 (Phosphotyrosine protein) phosphatases II 33-311 1.2e-29 99.5 In-house 47-285 (314) alignment 
Range on Protein: 33-311
Range on HMM: 47-285/314.0
RVYNRYNDILPSPaSRVILPEERGDPaTTYINANYLPFLgnpKAYIAAMGPLPTTIHSF----------LRMVI----EHKTVAM---------------
|  ||| |||| . .||||| . ..  . ||||.|.      ...||. |||. |...|          .|||.       .. |               
rdknryldilpad.nrvilpglpvsg.sdyinasyvdgf...lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivmsrdevladelsrLda

------VCPRSPPPqsvsaihcppnmrrlpcltmftRQ---------VmttnfeekgrkkCECYWPELPqdtmefgdikvfnegqqqeqffritrlrler
       .. ....                       .                       |.|.|||.                               
AlgKtpllildgng......................neptaadlellk............eelydpelf...............................

ggtIHRVTHFFYNTWPDRGVPRSDDnvmltrgVVKMLAAVRRHriqtdKATSPLLVHCSAGVGRTGCFVLIDQCFRLLehnqRLDLAALIKENRRYRM--
    ... ....  .|| ..| ..|       . ..|......     .. .|.||||.||.||||.||... . .||    ...|.  ... |. |.  
...erlgikylripvpDgsaplled.......fdeflefieea.....dkggpvlvHCkaGkgRtgtfvvaaylmkll....gvsleealedvrlkRpin

---AFVQTPEQFEFAWRTVAGYINFRLK
    |....||.|| .. .  |..| .|
pnpgfieqleqyefilealleylkflkk
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 136-306 1.2e-29 98.3 In-house 81-242 (250) alignment 
Range on Protein: 136-306
Range on HMM: 81-242/250.0
VMTTNFEEKGRKkCECYWPElpQDTMEFGDIKVFNEGQQQEQFFRITRLRLERGGTIHR--VTHFFYNTWPDRGVPRSddnvmlTRGVVKMLAAVRRHRI
|| ||..|.... .. |||   . . ..||..|    ...   . ...| | .    ..  | .. . .|||.|||.       .. |...|  |.. . 
vmLtnLkesekt.yhqywPv..ekaekyGdvtvsllskeefadytkrklklskakkaderivrqlhfvvWPdkgvPev......atavLellkkvqasqq

QTDkaTSPLLVHCSAGVGRTGCFVLIDQCFRLLEHNQRLDLAALIKENRRYRMAFVQTPEQFEFAWRTVAGYI
|..  ..|..|.|||||||.|.|. ||  .  |.... .|.  .||  |. |.  |.. ||. | .. .  ..
qag..naPvivqCsaGvgrsGafiaidavlerlkkekvvdvfkvikvlrkdrphavesleqyvfvyeiilkal
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 35-309 1.6e-29 97.5 In-house 48-239 (392) alignment 
Range on Protein: 35-309
Range on HMM: 48-239/392.0
YNRYNDILPSPASRVILPEERGDPATTYINANYLPFLGNPKAYIAAMGPLPTTIHSFLRMVIEHK--TVAMVCPRSPPPqsvsaihcppnmrrlpcltmf
 |||..|||  ..||.|      | . |.|| |.| . | |||||. || ..... | ||| ...  |.|||                            
knryknilpydsarvkleviddipdsdylnasyipsfdnekayiasqgpnaaslddfwrmvfqenvttiamvtklkegd.....................

trqvmttnfeekgrkkcecywpelpqdtmefgdikvfnegqqqeqffritrlrleRGGTIHRVTHFFYNTWPDRGVPRSddnvmlTRGVVKMLAAVrrhR
                                                       .|   . |. |..  |||..||.       |  ..|..  |   .
.......................................................kgddartvaqfhftewPdkdvpkh......tssllkfikev...k

IQTDKATSPLLVHCSAGVGRTGCFVLIDQCFRLLEHNQRLDLAALIKENRRYRMAFVQTPEQFEFAWRTVAGYINFR
..  . | ||..||||||||||  . ||      .. . .|.  .. . || |  .||| ||. | . .|   . .|
adfGqythpliihcsagvgrtgvvisidsvvahakktrmvdvfnfvtnirrkrpymvqtkeqyafiygavledllwr
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 136-308 1.2e-28 95.1 In-house 120-285 (319) alignment 
Range on Protein: 136-308
Range on HMM: 120-285/319.0
VMTTNFEEKGRKKCECYWPElpQDTMEFGDIKVFNEGQQQEQFFRITRLRLER-GGTI--HRVTHFFYNTWPDRGVPRSddnvmlTRGVVKMLAAVRRHR
|| |.  ||.. |.. ||||  .. .|.| . |  | ... . . | .| |..  . .   .|.|| |. ||| .||..      .......|  .|. |
vmltklveklkvklkkywpe..enfeeyGrlivtleeeeeledyiirklklnkkssevetRevkhfqyteWpdhdvPek......atslldllkrirksr

IQTDkaTSPLLVHCSAGVGRTGCFVLIDQCFRLLEHNQRLDLAALIKENRRYRMAFVQTPEQFEFAWRTVAGYINF
 .|.    |. ||||||||||| |. .|  .  ..... ||.   ... |  |   ||.|||..| . ..  ....
ektq..sgPivvhCsaGvGRtGtfivldamlervkeegvlDvfstvsrlRtqRnimvqrpeqYkfiyealleavea
subfamily_PTPRK_pd Subfamily PTPRK 135-300 2.3e-28 93.9 In-house 114-271 (314) alignment 
Range on Protein: 135-300
Range on HMM: 114-271/314.0
QVMTTNFEEKGRKKCECYWPElpqDTMEFGDIKVF--NEGQQQEQFFRITRLRL-ERG-GTIHRVTHFFYNTWPDRGVPRSDdnvmltRGVVKMLAAVrr
 || |.. |.|| ||  ||||   ||. .|||||   .   ..|   || |..  .||   |. | .| . .||| .|| |       .|..|... |  
ivmltelvevgrvkClkyWPe...dtevygdikvelvetellaelvvrifrveklargqeeirevrqfqflgWpdhdvPvsa......tgllklvrrv..

hRIQTDKATSPLLVHCSAGVGRTGCFVLIDQCFRLLEHNQRLDLAALIKENRRYRMAFVQTPEQFEFAWR
   ....   ...|||||| ||||.|. ||    ..|... .|.   .|. | ... .|.| ||. | . 
.kksqeeeaGrivvhCsaGaGrtGtfiaidivldmieregvvdvfnavktlrsrkvnmveteeqykfiyd
subfamily_PTPRG_pd Subfamily PTPRG 136-309 2.8e-27 90.2 In-house 120-290 (563) alignment 
Range on Protein: 136-309
Range on HMM: 120-290/563.0
VMTTNFEEKGRKKCECYWPElpQDTMEFGDIKVFNEGQQ-----QEQFFRITRLRLERGGT---IHRVTHFFYNTWPDRGVPRSDDNVmltrgvvkmLAA
|| ||..|.||.||. |||.  ......| ..|  . ..     ... . |  |.|...      ..|... | .||| ||| .   |         |  
vmitnlvergrrkcdvYWPk..desetygalqvtlieeevlalytvrtlviknlklkkkkqcdteklvrqyhytkWPdhgvPehslpv.........Lif

VRRHRIQTDKATSPLLVHCSAGVGRTGCFVLIDQCFRLLEHNQRLDLAALIKENRRYRMAFVQTPEQFEFAWRTVAGYINFR
|...   . ... |..||||||||||| .. .|   . .....  ..  ..|  |  |   ||| ||. | . ..   |. .
vkkssaankaeaGPivvHcsaGvgrtGtyivldtllkqiqqenavnvfgflkhiraqRnflvqteEqYiflhdalleaiask
subfamily_PTPN23_pd Subfamily PTPN23 136-303 3.1e-26 86.8 In-house 112-277 (288) alignment 
Range on Protein: 136-303
Range on HMM: 112-277/288.0
VMTTNFEEKGRKKCECYWPELPQDTMEFGDIKVFNEGQQQEQF--FRITRLRLERGGTIHRVTHFFYNTWPDRGVPRSDDNVMLTRGVVKMLAAVRRHRI
|| .. ||.|..|.. ||||   .|..|||..|  . ... .    |. .|. ..  ... |.|  ...||. ||| | ....   ..|.     .... 
VmllskeelgkpkvdrYwPedkgetvkfgdlsvtlksvretethvervlkletldadavksvshlqltsWpelGvPasPetllqfldevesayeavqrks

QTdkatsPLLVHCSAGVGRTGCFVLIDQCFRLL-EHNQRLDLAALIKENRRYRMAFVQTPEQFEFAWRTVA
.|     ||.||||||||||| | |.    | | ..|  ||.  ...  |. |   ||. ||..|..  | 
kt.....PlvvhCsaGvgRtgvfalvyaavrelekgnglldiiqvvsrlreqRrfmvqekeqlkfsyeavl
0043147 (Phosphotyrosine protein) phosphatases II 57-298 4.5e-26 87.0 In-house 2-153 (172) alignment 
Range on Protein: 57-298
Range on HMM: 2-153/172.0
DPATTYINANYLPFLGNPKAYIAAMGPLPTTIHSFLRMVIEHK--TVAMVCPRspppqsvsaihcppnmrrlpcltmftrqvmttnfeekgrkkcecywp
|. ..||||.||..   |. .||  |||. |...|.||. |..  .. .....                                               
degsdyinasyldlyyipdrfiatqgplrntladfwrmlkelgithivnltel...............................................

elpqdtmefgdikvfnegqqqeqffritrlRLERGGTIHRVTHFFYNTWPDRGVPrSDDNVMLTRGVVKMLAAVRRhriqtdkaTSPLLVHCSAGVGRTG
                               . . .  . . .. |  ||| ||| . . .. .   .. |.|...          | ||||||||||||
..............................lydpellerlgiqylylpwpDhgvp.llellleflefidellalsp........ggpvlVHCsaGvgRtg

CFVLIDQCFrllehnQRLDLAALIKENRRYRMAFVQTPEQFEFA
..|... .       ..|.|   ... |. |.  ||.|.|  | 
tlvaaylml......lglsleeavalvrekRpgavqnpsqyrfl
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 134-302 1.1e-25 85.3 In-house 119-275 (315) alignment 
Range on Protein: 134-302
Range on HMM: 119-275/315.0
RQVMTTNFEEKGRKKCECYWPELpqdTMEFGDIKVFNEGQQQEQFFRITRLRLERGGTIHRVTHFFYNTWPDRGVPRSDDNVMltrgvvKMLAAVRRHri
. || ||  |. ..|.| |||.     . .| | |    ..... . .  |    |  |. |  . | .||| |||..  ..|      ..   |..|  
kivmltnlvegekrkaekywpdk...kviyGkitvtrkseevnteytvrtlsvvfgdnirevvqlhytswpdmgvpkytiplm......nlirtvkqh..

qTDKATSPLLVHCSAGVGRTGCFVLIDQCFRLLEHNQRLDLAALIKENRRYRMAFVQTPEQFEFAWRTV
  ... ....||||||||||| |. .|  .  .| .. .|.  .|.  |. |.  ||. ||..| . ..
.htnsvgaivvhcsaGvGrtGtfitldavldqaeaenaidvynfitgvrqnrikmvqvaeqyqfiydal
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 136-302 1.3e-25 84.9 In-house 105-291 (297) alignment 
Range on Protein: 136-302
Range on HMM: 105-291/297.0
VMTTNFEEKGRKKCECYWPELPQDTMEFGDIKVFNEGQQQEQFFR--ITRLRLERGGTIHRVTHFFYNTWPDRGVP-RSDDNV-------------MLTR
|| ....| ||.||  |||.  |. .. ||. |    .  ..| |  .| |.|        |.|  . .||| |||   .| |              .  
vmvaklqedGrdkcapywpsvvqerlkagdvvveflsstsdefdrviltelqliyrsesrvvrhvqflswpdhGvpsdledlvrfqaqvcscciavpmml

GVVKMLAAVRRHRIQTDKATSP----LLVHCSAGVGRTGCFVLIDQCFRLLEHNQRLDLAALIKENRRYRMAFVQTPEQFEFAWRTV
..|.|..|.   .... .|  |    |||||||||||.|  || |     | ...  | ||...  |  |   ||| ||||. .  |
alvemftamvflqleslraemprnayllvhcsaGvGrsGvvvlsdvilaklrkkripdvaailsilreqrarlvqtleqfellydav
PTPc_DSPc_SM00012 195-302 1.6e-25 84.7 In-house 2-103 (105) alignment 
Range on Protein: 195-302
Range on HMM: 2-103/105.0
VTHFFYNTWPDRGVPRSDdnvmltRGVVKMLAAVRRHRIQTDKaTSPLLVHCSAGVGRTGCFVLIDQCFRLLEHN-QRLDLAALIKENRRYRMAFVQTPE
|.|. |..||| |||..         ....|.||.... . .. ..|..|||||||||||.||..| . . ||.. ...|.  ..|| |..|.  ||| |
vkhyhytgwpdhgvPees......dsilellravkknknkses.skpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqtee

QFEFAWRTV
|. |  | .
qylflyral
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 134-295 3.2e-25 83.4 In-house 121-272 (290) alignment 
Range on Protein: 134-295
Range on HMM: 121-272/290.0
RQVMTTNFEEKGRKKCECYWPELPQDTMEFGDIKVFNEG---QQQEQFFRITRLRLERGGTIHRVTHFFYNTWPDRGVPRSddnvmlTRGVVKMLAAVRr
  ||  .  |.|. ||| |.||   ... ||.| |       ....   ..  .|    |  |.. |.   .|||. |. |      |  ....| ..| 
aivmlceliedGkakceqyypekeGevltfGeitvlcseeddkdaniikktlsvrdkdsGkehklkhlkikswpdksvals......tlallrtlrilr.

hriqtdKATSPLLVHCSAGVGRTGCFVLIDQCFRLLEHNQRLDLAALIKENRRYRMAFVQTPEQF
      ||. |. ||||||.|||| || |. . ..| . . |||. |..  |. |.. ||   |.
......kasGpvvvhcsaGiGrtGtfvaievglqilldGkeldlldlvralrnsrlnsvqvdiqy
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 134-306 6.5e-25 82.6 In-house 118-283 (290) alignment 
Range on Protein: 134-306
Range on HMM: 118-283/290.0
RQVMTTNFEEKGRKKCECYWPELPQDTMEFGDIKVFNEGQQQEQFFRITRLRLERG-GTIHRVTHFFYNTWPDRGvprsddNVMLTRGVVkmLAAVRRHR
  || ||  |.|..||  |||. ......   ||. || . .|   |  ... ..  |. . ||..   .|.. |      .|  . ...  |.  .. .
iivmltniieegkvkCqqYWpdsdtkaygefsikllneetlneyierklevknknsagakqsvtqyqitnwdstg......kvtnpqtil..lvieemyk

IQTDKATSPLLVHCSAGVGRTGCFVLIDQCFRLLEHNQRLDLAALIKENRRYRMAFVQTPEQFEFAWRTVAGYI
.|  .   ...||||..|||.. |. ..      . ..  |. ...|. |  ..  ||| .|...  . |  |.
tqrkrgntsivvHCSdtvgrsavfcaaattinkcktegvidvfqvlksqRiqkpgsvqtvqqyqgifqivltyl
subfamily_PTPRN_pd Subfamily PTPRN 136-310 7.3e-24 79.0 In-house 129-296 (297) alignment 
Range on Protein: 136-310
Range on HMM: 129-296/297.0
VMTTNFEEKGRKKCECYWPELPQDTMEFGDIKVFNEGQQQEQFF-RITRLRLERGGTIHRVTHFFYNTWPDRGVPRSDDNVMLTRGVVKMlaAVrRHRiq
|. |. ||.| |.|. |||.  ... .. ....  |    .... |   |.  .      || | . .||..||| |  ...  |  |    .  | |  
vnltrleeegvkqckrywpdeGsevyhiyevhlvsehiwcddylvrsfylknlqtsetrtvtqfhflswpeegvPasaksllefrrkvnk..sy.rGr..

tdkaTSPLLVHCSAGVGRTGCFVLIDQ-CFRLLEHNQRLDLAALIKENRRYRMAFVQTPEQFEFAWRTVAGYINFRL
    ..|..||||.|.||||...|||  . |||   ...|.|| ..  |  |  .|.| .|||||. .||  .|  |
....scpivvhcsdGaGrtGvyilidlvlnrllkGvkeidiaatlehlrdqrpglvktkdqfefaltavaeevnail
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 136-306 3.2e-22 73.7 In-house 110-277 (287) alignment 
Range on Protein: 136-306
Range on HMM: 110-277/287.0
VMTTNFeEKGRKKCECYWPELpQDTMEFGDIKVFNEG--QQQEQfFRITRLRLERGGT--IHRVTHFFYNTWPDRGVPRSddNVMLTRGVVKMLAAVRRH
.|| .  |..|.||  ||||  .  |  |   |      ... . . .  |||    |   . |  . . .|||.... .   | | | |...   .   
tmtrev.eearlkcykywPer.evPmrvGGysvvlldydikePe.ygvralrlidletrearvvkqldllswPdkvlaPt..avglirfvldvkqhiela

RiqTDKATSPLLVHCSAGVGRTGCFVLIDQCFRLLEHNQRLDLAALIKENRRYRMAFVQTPEQFEFAWRTVAGYI
|    . . ||.||...|.||.| .. .  . . ||   |.| || .   | || |.||.. |. . . ... | 
r..dasevGPlvvhddvGiGrsGillatlvlvsrledlGrvdvaavvirlreyraalvqavvqlrllyealvtyy
0036282 (Phosphotyrosine protein) phosphatases II 136-298 3.3e-22 74.4 In-house 41-162 (174) alignment 
Range on Protein: 136-298
Range on HMM: 41-162/174.0
VMTTNFEEKGRKKCECYWPElpqdtmefgdikvfnegqqqeqffritrlrlERGGTIHRVTHFFYNTWPDRGVPrsddnvMLTRgVVKMLAAVRRHRIQt
|| .. .|.|. ||  ||||                                |    . . ...|  |||.|||       |.  . ... .|.... . 
vmlleekelglykcinywpe...............................lredlerlgiqylylpwpDhgvp......dlsi.llefvkfveealse.

dKATSPLLVHCSAGVGRTGCFVLIDQCFRLLEhNQRLDLAALIKENRRYRMAFVQTPEQFEFA
 .   |.||||||||||||..|... . |.|. .   |  .|..| |..|.  ||||.|..| 
.dpggpvlVHCsaGvgRtGtlvaaylmlrgll.eslvdaldlvrelRlqrpgmvqtpsQyrfl
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 135-307 8.3e-22 72.5 In-house 114-279 (287) alignment 
Range on Protein: 135-307
Range on HMM: 114-279/287.0
QVMTTNFEEKGRKKCECYWPELPQdtMEFG--DIKVFNEGQQQEQFFRITRLRLER-GGTIHRVTHFFYNTWPDRG-VPRSDDNvmltrgvvkMLAAVRR
 || .. .|. ...|  ||||     . .|   |.. || ....   |  ... .   |. ..|. . . .|...| |..             .|   ..
ivmlcqekendeevcyqyWpeeks..vvlGeyniellneevnagyierklevknknkagdkqqvkqyqitnWdstgkvtepqti.........llvieem

HRIQTDKATSPLLVHCSAGVGRTGCFVLIDQCFRLLEHNQRLDLAALIKENRRYRMAFVQTPEQFEFAWRTVAGYIN
 . |  .. ....||||..|||.. |. ..   .  . .  .|.  ..|. |  ..  ||| ||..|    |  |..
yktqrkrgntsivvhCsdtvGrsamfcaaattinkckteGviDvfqvlksqriqkpgsvqtveqykfindivleyld
0046846 (Phosphotyrosine protein) phosphatases II 136-301 3.4e-21 71.2 In-house 52-168 (176) alignment 
Range on Protein: 136-301
Range on HMM: 52-168/176.0
VMTTNFEEKGRKKCECYWPELPQDTMefgdikvfnegqqqeqffritrlrlerggtihrvtHFFYNTWPDRGVPRSDDnvmltrgVVKMLAAVRRHRIQT
|. |.  |.|| ||  ||||| .  .                                   ....  ||| ||| ...       . ..|...|... . 
vnlteevelgrlkcpnywpeleklgi...................................qylhlpwpDhgvpdlel.......llellefirealkeg

dkatSPLLVHCSAGVGRTGCFVLIDqcfrLLEHNQRLDLAALIKENRRYRM-AFVQTPEQFEFAWRT
     | |||||||.||||..|...    |||... |..   ... |..|.   |||||| .|  . 
....gpvlVHCsaGigRtgtlvaay....llelekglsveealalvreqRplgavqtpeQyrflyef
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 136-307 5.9e-21 69.7 In-house 111-278 (307) alignment 
Range on Protein: 136-307
Range on HMM: 111-278/307.0
VMTTNFEEKGRKKCECYWPELPQDTMEFGD----IKVFNEGQQ----QEQFFRITRLRLERGGTIHRVTHFFYNTWPDRGVPRSDdnvmLtrGVVKMLAA
.|  .  | .. ||| |||    ... ||.    | | | | .    .|..  .| |... ..    ..|. .. |||||||. .    |  . . .| |
imlckvielakikceqywpleegqklvfgeapntisvanlgakklapdedlinvttlkvdwaqksrtiqhlqwenwpdrgvpqin....l..tainllea

VRRHriqtdkaTSPLLVHCSAGVGRTGCFVLIDQCF-RLLEHNQRLDLAALIKENRRYRMAFVQTPEQFEFAWRTVAGYIN
|| .       | |..|||||||||.|  | |     ....     |.  |..| |  |   .||  |. .  | .  |  
vryd.......tnpvvvhcsaGvGrsGtivaislvqdkmiaGinckdmkklveelrsqrhyaiqteaqylylhrvlleyfl
subfamily_ptpA1_pd Subfamily ptpA1 35-269 1.1e-20 68.8 In-house 50-259 (418) alignment 
Range on Protein: 35-269
Range on HMM: 50-259/418.0
YNRYNDILPSPASRVILPEERGDPATTYINANYLPFlGNPKAYIAAMGPLPTTIHSFLRMVIEHKTVAMVCprspppQSVSAIHCppnmrRLPCLTMFTR
 ||| .|||   .|| | . .    . ||||||.     || .|.. |||| ||  | ||| | .   .|        |  .  |     |. |   .  
knrytnilpvnhtrvqlkkiqdkegsdyinanyidg.aypkqfictqgplpntiadfwrmvwenrcriivm......lsresenc.....rikcdrywpe

QVMTTNFEEKGRKKcECYwpelpqDTMEFGDIKVFNEGqQQEQFFRITRLRLErgGTIHRVTHFFYNTWPDRGVPrsdDNVMLTRGVVKMLAAVRRHRIQ
|.   .|   |  . | .       |     ..| ..  ..|   |  || .|  |  . .|.. |. |||. .|   |     | ... ..  . . | 
qiggeqfsiygngn.evf......gtysvelveviqdp.ereiitrnirltfe..getrditqyqyegwpdhnip...dhtqpfrqllhsitnrqnqiip

TDKATSPLLVHCSAGVGRTGCFVLIDQCFRLLEHN
.     |..||||||||||| |.     .. |.| 
ssdrnvpiivhcsagvgrtgtfctavimmkkldhy
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 136-307 1.9e-20 67.8 In-house 117-288 (305) alignment 
Range on Protein: 136-307
Range on HMM: 117-288/305.0
VMTTNFEEKGRKKCECYWPELPQDTMEFGD----IKVFNEGQQQEQFFR-------ITRLRLER-GGTIHRVTHFFYNTWPDRGVPRSDDNvmltrgVVK
 |  |. ||| |||  |..   .|..|| .    | |  |  .. .| .        | | .|  |.. ..|||. .. ||||||| .|        ...
fmlcnllekgakkcleyfaskdkdvlefeekgqkisvkfessvtlkfrkdakakvtetvlviegpgekarkvthyhwidwpdrgvpaadla......ile

MLAAVRrhriqtdKATSPLLVHCSAGVGRTGCFVLIDQCF-RLLEHNQRLDLAALIKENRRYRMAFVQTPEQFEFAWRTVAGYIN
.|.  |        .  |. ||||||.||||  |...  . .||. ..  |   ...  |  |   .|| .|. |  . .  |..
llekar.......pskgpivvhcsagigrtgsvvmleyildqllagqiiedtdkilqkireqrnnsiqtdaqylfvhqvilnyfr
0050432 (Phosphotyrosine protein) phosphatases II 33-105 5.4e-20 67.4 In-house 69-138 (308) alignment 
Range on Protein: 33-105
Range on HMM: 69-138/308.0
RVYNRYNDILPSPASRVILpeergDPATTYINANYLPFL--GNPKAYIAAMGPLPTTIHSFLRMVIEHKTVAMVC
.  ||| ||||   |||.|     |. ..||||.| ..   ..|...||. ||||.|...| ||| |...   |.
kdkNrykdilpydhsRVkl.....degsdYInAsyvdgyssklprkfIatqgPlpntvedFwrmvweqnvrvIvm
0049260 (Phosphotyrosine protein) phosphatases II 135-297 7.9e-20 66.5 In-house 37-141 (152) alignment 
Range on Protein: 135-297
Range on HMM: 37-141/152.0
QVMTTNFEEKGRKKCECYWpelpqdtmefgdikvfnegqqqeqffritrlrlerggtihrvtHFFYNTWPDRGVPRSDDNVMLTRGVVKMLaA-VRRHri
 || |...|.|. ||| |.                                           ....  ||| ||| ... ..    ... | |  . .  
ivmltellelgklkceqyi...........................................qylhlpwpDhgvpdlsqlllflllfiekl.aldkgg..

qtdkatsPLLVHCSAGVGRTGCFVLIDQCFrllehnQRLDLAALIKENRRYRMAFVQTPEQFEF
       | ||||||||||||..|... .       ....|   ..  |. |.  |..|.| .|
.......pvlVHCsaGvgRtgtlvaaylml......lgvsleeavalvrekRpgavpnpgqlrf
0040438 (Phosphotyrosine protein) phosphatases II 35-105 1.2e-19 66.2 In-house 46-116 (317) alignment 
Range on Protein: 35-105
Range on HMM: 46-116/317.0
YNRYNDILPSPASRVILPEERGDPATTYINANYLPFLGNPKAYIAAMGPLPTTIHSFLRMVIEHKTVAMVC
.||| |||| ..|||.|  . ||. ..||||.| ..   ....||. |||| |...|.||| |...   |.
knrypdilpydhsRVkLsplggdldsdYInAsyvdgpnlkrkfIatqgPlpntvedFwrmvweqgvtvivm
subfamily_PTPRD_pd Subfamily PTPRD 36-104 3.8e-19 63.8 In-house 52-120 (564) alignment 
Range on Protein: 36-104
Range on HMM: 52-120/564.0
NRYNDILPSPASRVILPEERGDPATTYINANYLPFLGNPKAYIAAMGPLPTTIHSFLRMVIEHKTVAMV
|||..|..  .|||.| . .||. . ||||...    ..|||||. |||..||. | ||| |...   |
NRyanivaYdhsRVvLskvegdegsDYINAsfidgyrkrkayIAtqgPlaetiedFWRmvweqnsstiV
DSPc_SM00195 36-105 4e-19 64.3 In-house 30-99 (263) alignment 
Range on Protein: 36-105
Range on HMM: 30-99/263.0
NRYNDILPSPASRVILPEERGDPATTYINANYLPFLGNPKAYIAAMGPLPTTIHSFLRMVIEHKTVAMVC
|||..|||   .||.|..| ... ..||||||. .  ..|.|||. ||||.|...| |||.|.|.   |.
nRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivm
PTPc_SM00194 36-105 4e-19 64.3 In-house 30-99 (263) alignment 
Range on Protein: 36-105
Range on HMM: 30-99/263.0
NRYNDILPSPASRVILPEERGDPATTYINANYLPFLGNPKAYIAAMGPLPTTIHSFLRMVIEHKTVAMVC
|||..|||   .||.|..| ... ..||||||. .  ..|.|||. ||||.|...| |||.|.|.   |.
nRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivm
0036941 (Phosphotyrosine protein) phosphatases II 34-105 7.8e-19 63.5 In-house 41-108 (297) alignment 
Range on Protein: 34-105
Range on HMM: 41-108/297.0
VYNRYNDILPSPASRVILpeerGDPATTYINANYLPFLGNPKAYIAAMGPLPTTIHSFLRMVIEHKTVAMVC
  ||| |||| . .||.|    .|. . ||||.|... . ....||. ||||.|...| ||| |...   |.
eknRykdilpydhtRVkl....ddegsdYinAsyvdgydlkrkfIatqgPlpntvedFWrmvweqnvtvIvm
0047943 (Phosphotyrosine protein) phosphatases II 33-106 1.4e-18 62.8 In-house 39-108 (273) alignment 
Range on Protein: 33-106
Range on HMM: 39-108/273.0
RVYNRYNDILPSPASRVILpeerGDPATTYINANYLPFLGNPKAYIAAMGPLPTTIHSFLRMVIEHKTVAMVCP
. .||| ||||   |||.|    ||. . ||||.|...   ....||. |||| |...|.||| |...   |. 
kdknrykdilpydhsrvkl....gdggsdyinAsyvdgynlkrkfiatqgPlpntvedfwrmvweqnvrviVmL
0043336 (Phosphotyrosine protein) phosphatases II 33-108 1.4e-18 62.9 In-house 46-121 (278) alignment 
Range on Protein: 33-108
Range on HMM: 46-121/278.0
RVYNRYNDILPSPASRVILPEERGDPATTYINANYLPFLGNPKAYIAAMGPLPTTIHSFLRMVIEHKTVAMVCPRS
.  ||| |||| . |||.|  . ||. ..||||.|...   |...||. |||| |.. | ||| |...   |. ..
kdknrykdilpydhsrvklsllggdldsdYinAsyvdgynvprkfiatqgPlpetvedFwrmvwelgvttivmLte
subfamily_PTPN12_pd Subfamily PTPN12 35-105 2.2e-18 61.2 In-house 43-115 (290) alignment 
Range on Protein: 35-105
Range on HMM: 43-115/290.0
YNRYNDILPSPASRVILPEERGDPATTYINANYLPFLGNPKAYIAAMGPLPTTIHSFLRMVIEHKT--VAMVC
 ||| ||||   ||| | ......   |||||..    ....|||| ||||.|.. | ||..|...  | |.|
knrykDilPydksrvelskieeeegsdYinanfikgvegkleyiaaqgPLpktlddfWrmiweknveivvmaC
subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 134-306 2.5e-18 61.1 In-house 55-221 (255) alignment 
Range on Protein: 134-306
Range on HMM: 55-221/255.0
RQVMTTNFEEKGRKKCECYWPELPQDTMEFGDIKVFNEGQQQEQFFRITRLRLERG--GTIHRVTHFFYNTWPDRGVPRsddnvmLTRGVVKMLAAVRRH
  || ..|.|.|..||. |.|   .. . . |..|      ..  .|  .. .. |     | |.|..|. |...  |.      |.| . ..| .||  
vvvmlcdfaeegvekcssyfplekdeklkladvnvtttkssadvvlrtleitstlgekkkthtvkhysykGWieknaPe......lareilnilkvvrds

RiqtdkatsPLLVHCSAGVGRTGCFVLIDQCFR----LLEH--NQRLDLAALIKENRRYRMAFVQTPEQFEFAWRTVAGYI
.        ...||||.|.||.  |||..  ..     |.      ||   |..| |  | . ..|| |. |.  .|  ..
k........svvvhCstGiGrsaafvlaelvyqkmirsldttetveldylslleelrskrkraihtPlqlafsilmvldlv
0051082 (Phosphotyrosine protein) phosphatases II 123-299 2.8e-18 61.4 In-house 57-146 (151) alignment 
Range on Protein: 123-299
Range on HMM: 57-146/151.0
MrrlpcltmftrqvmttnfeekgrkkcecywpelpqdtmefgdikvfnegqqqeqffritrlrlerggtiHRVTHFFYNTWPDRGVPRSDdnvmltRGVV
                                                                      ..|.|. .  ||| |.| |         |.
g.....................................................................ievlhipildwpdpglplsf......davl

KMLAAVRRhriqtdKATSPLLVHCSAGVGRTGCFVLIDQCFrlLEhnqrLDLAALIKENRRYRMAFVQTPEQFEFAW
..| ....      |   |.|||||||.||||..|... .   |     ..|.. ..| |..|. .||...|| |  
eflellld......kkngpvlvHCsaGkgRTGtlvalylml..lg....vsleealeeyrlkrpgvvqpnqqflfql
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 136-302 3.1e-18 60.8 In-house 74-235 (237) alignment 
Range on Protein: 136-302
Range on HMM: 74-235/237.0
VMTTNFEEKGRKKCECYWPELPQDtMEFGDIKVFNEGQQQEQFFRITRLRLERGGTIHRV---THFFYNTWPDRGVPRSDDNVMLTRgvvKMLAAVRRHR
|| | . |. ..||  |||.  |    .| . |    ...   . .  | | . .|.. |     . . .|||||||.    ..  |   | .    .| 
vmltgliegnelkchkywpstdqp.aaygvltvslkkkeefsdytvrslllskrltlkevrlihqyqftswpdrgvpqqtaallrfr...kniinrsphv

iqtdKATSPLLVHCSAGVGRTGCFVLIDQCFRLLEHNQRLDLAALIKENRRYRMAFVQTPEQFEFAWRTV
      ..| ..|||||||||| |..||  .|  . .. .|.   ..     |   .|| .|. |  .|.
....sesgpwiihcsagvgrtgiflvidamlrqakekkvvdiynyvysieedrpyiiqtkdqyvfihqti
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 136-299 3.1e-18 60.8 In-house 80-233 (239) alignment 
Range on Protein: 136-299
Range on HMM: 80-233/239.0
VMTTNFEEKGRKKCECYWPElpqDTMEFGDIKVFNEGQQQEQFFRITRLRL-ERGGTIHR-VTHFFYNTWPDRGVPRSDDNVMLTRgvvkmlaavRRHRI
|| | . |  .|||  |||.    | .. ...|     .    . |  . . . | |  | | ....  |||.|||.    |.  |         |.   
vmltglieghkkkchqywpd...stskycnlrvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglr.........rkitk

QTDKATSPLLVHCSAGVGRTGCFVLIDQCFRLLEHNQRLDLAALIKENRRYRMAFVQTPEQFEFAW
..   . | ..||||||||||.|..||  .|  .... .|.   .|  |  |  .||| ||. |  
dslpgarpwvihcsagvgrtgaflvidamlrqakkqktvdifnyvkairedrphmvqtseqyvfih
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 136-299 3.4e-18 60.7 In-house 81-234 (239) alignment 
Range on Protein: 136-299
Range on HMM: 81-234/239.0
VMTTNFEEKGRKKCECYWPElpqDTMEFGDIKVFNEGQQQEQFFRITRLRL-ERGGTIHR-VTHFFYNTWPDRGVPRSDDNVMLTRgvvkmlaavRRHRI
|| | . |  .|||  |||.    | .. ...|     .    . |  . . . | |  | | ....  |||.|||.    |.  |         |.   
vmltglieghkkkchqywpd...stskycnlrvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglr.........rkitk

QTDKATSPLLVHCSAGVGRTGCFVLIDQCFRLLEHNQRLDLAALIKENRRYRMAFVQTPEQFEFAW
..   . | ..||||||||||.|..||  .|  .... .|.   .|  |  |  .||| ||. |  
dslpgarpwvihcsagvgrtgaflvidamlrqakkqktvdifnyvkairedrphmvqtseqyvfih
0048076 (Phosphotyrosine protein) phosphatases II 159-299 4e-18 60.9 In-house 9-136 (145) alignment 
Range on Protein: 159-299
Range on HMM: 9-136/145.0
DTMEFGDIKVFNEG--QQQEQFFRITRLRLERGGTIHRVTHFFYNTWPDRGVPRSDDNvmltrgVVKMLAAVRRHRIQtdkaTSPLLVHCSAGVGRTGCF
. . .|.. . ..    .. .. .. .|  |. .  . .....|  |||.||| . .       . ..|....... .      | ||||||||||||..
pglylgslptaldlellkdlgittvlnltselellerlgiqylylpwpDhgvpdllel......lleflefieealke....ggpvlVHCsaGvgRtgtl

VLIDQCFRllehnQRLDLAALIKENRRYRMAFVQTPEQFEFAW
|... ...     ....|   ... |..|. .|..|.|..|  
vaaylmll.....lgvsleealelvrsqrpgavpnpgqlrfly
subfamily_PTPRB_pd Subfamily PTPRB 33-104 7.2e-18 59.6 In-house 52-123 (293) alignment 
Range on Protein: 33-104
Range on HMM: 52-123/293.0
RVYNRYNDILPSPASRVILPEERGDPATTYINANYLPFLGNPKAYIAAMGPLPTTIHSFLRMVIEHKTVAMV
|  |||..|||  .||| | . .... . ||||||.| .  |. .||. ||||.|.. | ||| |.|. ..|
raknrytnilpydhsrvkLaalkdesgsDYinanyipgynsprefiatqGPlpetvddfWrmvwekkssiiv
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 135-299 8.7e-18 59.2 In-house 103-259 (283) alignment 
Range on Protein: 135-299
Range on HMM: 103-259/283.0
QVMTTNFEEKGRKKCECYWPElpQDTMEFGDIKVFNEGQQQEQFFRITRLRLERG----GTIHrVTHFFYNTWpdrgvpRSDDNVMLTRGVVKMlAAVrr
 || |.. |  |.||  |||.  . ....|.  |  . .  .. | |  | |        |.  ..|. .. |       . ..      .||.   |  
ivmltklqedlrikCsqyWPk..rGsedyGeftvtlrkettsnsfiikelllrvnssakstll.lahyqvidW......leygeqaiinslvkf.nkv..

HRIQTDKATSPLLVHCSAGVGRTGCFVLIDQCFRLLEHNQRLDLAALIKENRRYRMAFVQTPEQFEFAW
   ||..  .|..||||.|.|||. |. .      .  .  .|. | .|  |  ||  ||| .|. .  
islqteskkgPivvhCstgiGrtavfiaasasvkdaltesvvdvfavvkimreqrmmavqtldqyklvh
0044763 (Phosphotyrosine protein) phosphatases II 45-297 1e-17 59.8 In-house 3-162 (178) alignment 
Range on Protein: 45-297
Range on HMM: 3-162/178.0
PASRVILPEERGDPATTYINANYLPflgnPKAYIAAMGPlpttiHSFLRMVIEHK--TVAMVCPRSPPPQsvsaihcppnmrrlpcltmftrqvmttnfe
. .||.|.. .| ... ||||..      |  |... .|      ..|... |..  .. ....  ....                              
drtrvllsnleglersdyinaseil....pglylgslpp.....addlellkelgithivnlteelelgf..............................

ekgrKKCECYWPELPQdtmefgdikvfnegqqqeqffritrlrlerggtihrvTHFFYNTWPDRGVPRSDDNVMLTRGVVKMLAavrrhriqtDKATSPL
     ||  ||||                                         ....  .|| ||| ... .. .   .. .          |.  .| 
....lkcdpywpeeag.....................................iqylhipipDhgvpdllehflefvefieeal.........dekggpv

LVHCSAGVGRTGCFVLIDQCFRLlehnqRLDLAALIKENRRYRMaFVQTPEQFEF
||||||||||.|..|... . .|     .|.| . |.. |..|. .|..|.| ..
lVHCsaGvgRsgtlvaaylmkkl.....glsleeaielvrerRp.ivpnpgqlrq
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 136-309 1.1e-17 59.0 In-house 111-274 (288) alignment 
Range on Protein: 136-309
Range on HMM: 111-274/288.0
VMTTNFEEKGRKKCECYWPELPQDTMEFGDIKV--FNEGQQQEQFFRITRLRLERGGTIHR-VTHFFYNTWPDRGVPrsdDNVMltrGVVKMLAAVrrhr
|| ... |||..| . |.|    ... .| .     .. .. ..  ... || .. |  .  | .  .. |.| |||   .| .     ...|  .    
vmlcellekGkeksaeyfPsklGekarigrlctvvkkkradidklvkvsllriskegeekvivkilhlleWdddgvP...enyl...splrllevl....

iqtDKATSPLLVHCSAGVGRTGCFVLIDQCFRLLEHNQRLDLAALIKENRRYRMAFVQTPEQFEFAWRTVAGYINFR
    . . |..||.|||||||| ..||    . |  .  | .  |... |  |.  .||  |. ...| |  .. ..
...kslqkPivvhssaGvGrtgtlililialeslrlddflgirsllaklreerfkaiqtemqylyvhrcvleelllk
subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 133-302 1.6e-17 58.0 In-house 107-265 (281) alignment 
Range on Protein: 133-302
Range on HMM: 107-265/281.0
TRQVMTTNFEEKGRKKCECYWPELPQDTMEFGDIKVFNEGQQQEQFFRITRLRLERGGTIHRVTHFFYNTWPDRGVPRSDDnVMLtrgvvKMLAAVRrhr
|  ||  .| |  |.||  |.|   .  ..|  . |  |    .. .  ||| |   |  . .||.... |||  || | . |||     |.|  .|   
taivmlcqfletnrekcaeyfprnahcclqfdklsvsyedstvnkslvttrlnlsyegetrlithwlwkewpdwqvpesse.vml.....kilrkir...

IqtdKATsPLLVHCSAGVGRTGCFVLIDQCFRLL-EHNQRLDLAALIKENRR-YRMAFVQTPEQFEFAWRTV
    ..| | ..||||||||.| .. .. ... .  |    |.  ..   |   | | ||| .|. . |. .
a...rst.ppvihcsagvgrsgtlmaveialqsihshftlpdikqivshlrvtgraasvqtlqqymliwkvl
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 33-104 5.4e-17 56.8 In-house 47-118 (318) alignment 
Range on Protein: 33-104
Range on HMM: 47-118/318.0
RVYNRYNDILPSPASRVILPEERGDPATTYINANYLPFLGNPKAYIAAMGPLPTTIHSFLRMVIEHKTVAMV
.  |||..||.   .|| | .  |.. . ||||||..   . |||||| .||| ||. | ||| | ..  .|
kaknryanilaydhtrvkLqmlegeegsDyinanyidGyrrkkayiaaqaPlpetieDfWrmvWeqnsaviv
subfamily_hpo-7_pd Subfamily hpo-7 134-304 5.9e-17 56.4 In-house 61-225 (263) alignment 
Range on Protein: 134-304
Range on HMM: 61-225/263.0
RQVMTTNFEEKGRKKCECYWPELPQDTMEFGDIKVFNEGQQQEQFFRITRLRL--ERGGTIHRVTHFFYNTWPDRgvprsdDNVMLTRGVVKMLAAVRRH
  || ..|.|.|..||. |.|    . . . ...|     |..   .   |    ..  ..| |.|..|. |...       ...|.| ....| ..|  
vvvmLcDfneegvekcssyfPlekdekqklanvnvcttkvqsdvllktlellstlgeKkkthtvkhysykgWiek......ndpelareilnilkvarns

RiqtdkatsPLLVHCSAGVGRTGCFVLIDQCFR----LLEH--NQRLDLAALIKENRRYRMAFVQTPEQFEFAWRTVAG
.        .| ||||.|.||.  |..... ..     |.      ||   |..| |  | . ..|| |. |.  .|  
k........slvvhcstGiGrsaafsvaElvyqkmirsldttstveldylsLleelrssrkraihtPmqLafsilmvLd
0040439 (Phosphotyrosine protein) phosphatases II 34-110 6.6e-17 57.4 In-house 13-89 (249) alignment 
Range on Protein: 34-110
Range on HMM: 13-89/249.0
VYNRYNDILPSPASRVILPEERGDPATTYINANYLPFLGNPKAYIAAMGPLPTTIHSFLRMVIEHKTVAMVCPRSPP
 .||| |||| . |||.|   .| . . ||||.|...   ....||. |||| |...|.||. |..  . |. .|. 
dknrypdilpydhsrvklsilpglflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslv
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 136-311 7.3e-17 56.0 In-house 125-294 (305) alignment 
Range on Protein: 136-311
Range on HMM: 125-294/305.0
VMTTNFEEKGRKKCECYWPELPQDTMEFGD-IKVFNE-G---QQQEQFFRITRLRLER-GGTIHRVTHFFYNTWPDRGVPRSDdnvmLTrgVVKMLAAVR
||  .  | |. ||  |||    . .|.   | | |  |    ...   .|| |.|   |.    | |. .. |||||||       ||   ...|.|.|
vmlcktvelgklkcaqywpaaqgeklelksgivvenvsgskpmerdaeiqitllnltysgdqkmsvrhlqwtewpdrgvppck....lt..slellsair

RHRIqtdkatsPLLVHCSAGVGRTGCFVLIDQCFR-LLEHNQRLDLAALIKENRRYRMAFVQTPEQFEFAWRTVAGYINFRLK
  ..       |..||||||.||||  | |.  .  . | ..   .  |.|  |  |   .|.  |. |  | .  |.  . |
gskv.......pivvhcsagigrtgtivaieyilekiaenkpcppmpelvkalrdqrafsiqndvqylfihrvmlnyflekyk
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 195-303 1.1e-16 55.2 In-house 91-191 (440) alignment 
Range on Protein: 195-303
Range on HMM: 91-191/440.0
VTHFFYNTWPDRGVPRsddnvmLTRGVVKMLAAVRRHriQTDKATSPLLVHCSAGVGRTGCFVLIDQCFRLLEHNQRLDLAALIKENRRYRMAFVQTPEQ
. ...|. |||.|||.      ..  |.||.  |     |   . .|||||||||.||||  . .|  .|  ......|. ..|.  |  |  .||||||
lkqyhyqgwpdkgvpk......fagpvlkmiqdvnes..qekagngpllvhcsagagrtgviiavdsilreakrsdqidifsfinsmrnnrpqmvqtpeq

FEFAWRTVA
. |   .| 
yafvheavl
subfamily_CG7180_pd Subfamily CG7180 136-306 2.3e-16 54.3 In-house 114-290 (296) alignment 
Range on Protein: 136-306
Range on HMM: 114-290/296.0
VMTTNFEEKGRkKCECYWPELPqdTMEFGDIKVFNEGQQQEQFFRITRLRLERG-----------G-TIHRVTHFFYNTWPD-RGVPRSDDNVMLtrgVV
|. |.  .  . ..  |||.      ..|.| |    ..|   ..|  ..| .                  |..| . .|.    || |   ..    ..
vvLtktfdfak.mypsywpnks..keqygeifveiveekqyanlkirtfkltkkivalteqekqvkaetRivklfqlteWeledkvPlstnalie...lr

KMLAAVrRHRIQTDKATSPLLVHCSAGVGRTGCFVLIDQCFRLLEHNQRLDLAALIKENRRYRMAFVQTPEQFEFAWRTVAGYI
..   . |.... |. ..|..|..| |..|.| .. || .  |.|.....|.   .|  || |   |.. |.. . . ..  ..
rrvrlw.rekvdedpeegPvvvvssdGasRsGvylaidanlelvekeeevdvFeavktlrrsRpqLvenveeYkyiYdvlleav
0048179 (Phosphotyrosine protein) phosphatases II 191-298 2.4e-16 55.2 In-house 43-137 (144) alignment 
Range on Protein: 191-298
Range on HMM: 43-137/144.0
TIHR--VTHFFYNTWPDRGVPRSDDNVMLTRGVVKMLaavrrhriqtDKATSPLLVHCSAGVGRTGCFVLIDQCFrllehNQRLDLAALIKENRRYRMAF
.     ......  |||.||| . . .  .   .. .           .   | ||||||||||||..|... ..      ..|.|   ... |..|.  
efleregiqylhlpwpDhgvpdllellleflefieea..........leeggpvlVHCsaGvgRtgtlvaaylmk.....klglsleealalvrsrrpga

VQTPEQFEFA
|..|.|..| 
vpnpgqlrfL
Y_phosphatase Protein-tyrosine phosphatase 36-105 3.2e-16 54.8 Pfam-A 5-72 (235) alignment 
Range on Protein: 36-105
Range on HMM: 5-72/235.0
NRYNDILPSPASRVILpEERGDPATtYINANYLPFLGNPKAYIAAMGPLPTTIHSFLRMVIEHKTVAMVC
|||.||||   .|| | .....|   ||||||.    ..|..||. |||. ||..| |||...|. . |.
nRykdilpydktrvkl.kgsegpsd.YInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivm
Y_phosphatase Protein-tyrosine phosphatase 36-105 3.2e-16 54.8 In-house 5-72 (235) alignment 
Range on Protein: 36-105
Range on HMM: 5-72/235.0
NRYNDILPSPASRVILpEERGDPATtYINANYLPFLGNPKAYIAAMGPLPTTIHSFLRMVIEHKTVAMVC
|||.||||   .|| | .....|   ||||||.    ..|..||. |||. ||..| |||...|. . |.
nRykdilpydktrvkl.kgsegpsd.YInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivm
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 35-104 4e-16 54.0 In-house 51-120 (319) alignment 
Range on Protein: 35-104
Range on HMM: 51-120/319.0
YNRYNDILPSPASRVILPEERGDPATTYINANYLPFLGNPKAYIAAMGPLPTTIHSFLRMVIEHKTVAMV
 |||..||.   .||.|.|  | . ..||||...    . ...||...|| .||. | ||| |...  .|
knryqnilaydrtrvvlseldgvegsdyinasfidgyqerekfiatqaPlentiedfWrmvWeeessivv
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 33-104 6.8e-16 53.2 In-house 42-113 (281) alignment 
Range on Protein: 33-104
Range on HMM: 42-113/281.0
RVYNRYNDILPSPASRVILPEERGDPATTYINANYLPFLGNPKAYIAAMGPLPTTIHSFLRMVIEHKTVAMV
.. |||..|    |.|| . ..  .  | |||||..| . ..|.|||. ||.|.....| .||.|.|  |.|
vlknrYsnivaYDatrvkvtpneenkntDYinanfvpgykgekeyiatqgPvPaslvafWqmvweqkvsaiv
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 136-308 8.2e-16 52.5 In-house 120-281 (439) alignment 
Range on Protein: 136-308
Range on HMM: 120-281/439.0
VMTTNFEEKGRkkcecYWPElpQDTMEFGDIKVFNEGQQQEQFFRITRLRL----ERGGTIHRVTHFFYNTWPDRGVPRSDDNvmltrgVVKMLAAVRRh
|| ||. |  .     |||   .. . .||| |  . . .   . |  ...    ...   . | .| | .|||. ||           |...| |.   
vmltnlvesyk.....ywps..daevcygdiavrvdrnielpnyvirgfkvfnerdttekertvlqfhyiawpdknvpaqash......vldflrains.

rIQTDKATSPLLVHCSAGVGRTGCFVLIDQCFRLLEHNQRLDLAALIKENRRYRMAFVQTPEQFEFAWRTVAGYINF
  . .. . |..|||||||||||  . .| ..  |  ....|.  ..|  |. |  .||.  |. | . .|   | .
.andkeeygpvvvhcsagvGrtGtiialdialeqlklenkvdikgivkvlrkqrkqmvqalcqyvfiynavledivy
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 34-104 2.4e-15 51.6 In-house 58-128 (298) alignment 
Range on Protein: 34-104
Range on HMM: 58-128/298.0
VYNRYNDILPSPASRVILPEERGDPATTYINANYLPFLGNPKAYIAAMGPLPTTIHSFLRMVIEHKTVAMV
  ||| ||...  |||.| .| .|  ..|||| .|    . .|.||. .||..|.. | |||.|..  ..|
kkNRyadiialdssRvvLekedadeesdYiNAsflhaykgrnafiatqaPltetvedFWrmvteedigtiV
subfamily_PTPRA_pd Subfamily PTPRA 35-104 3.2e-15 50.9 In-house 61-130 (330) alignment 
Range on Protein: 35-104
Range on HMM: 61-130/330.0
YNRYNDILPSPASRVILPEERGDPATTYINANYLPFLGNPKAYIAAMGPLPTTIHSFLRMVIEHKTVAMV
 ||. .|||   |||||.. .| . . |||| ..    . . .||| ||.  |.. | ||. |.|. ..|
knrvvnilPydfsrvilsvkeGveesdyinasfidGykekdkfiaaqGPkeetvedfwrmiweqksativ
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 150-312 3.2e-15 50.9 In-house 112-265 (267) alignment 
Range on Protein: 150-312
Range on HMM: 112-265/267.0
ECYWPELPQDTMEFGDIKVFNEGQQQEQFFRITRLRLE-RGGTIHRVTHFFYNTWPdrgVprSDDNVMLTRGVVKMLAavrrhRIQTDKATSPLLVHCSA
  .||    .. .. |. |    ...|. ..|  | |. .  . | || ..|. |    .    .|    . .. .||     . | ...  ||.|.||.
rlfwPPkmgqakkyqdltvehslekeendyqiitlelkfknesahnvtlyyykkwn...i..ntnnkpylkplfgila.....knqlengnrPlvvacsd

GVGRTGCFVLIDQCFRLLEHNQRLDLAALIKENRRYRMAFVQTPEQFEFAWRTVAGYINFRLKT
||||.| |. ||  .. . ... .|.  .... |  |...|.| |.. .  ...| | ..||| 
GvGrsGtflvidsqleraktegvsdifdflrkirsqriglvdtkeryiyihellaeyaegrlke
subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 135-302 3.8e-15 50.4 In-house 118-275 (301) alignment 
Range on Protein: 135-302
Range on HMM: 118-275/301.0
QVMTTNFEEKGRKKCECYWPELPQDTMEFGDIKVFNEGQQQEQFFRITRLRLERGGT-----IHRVTHFFYNTWPDRGVPRSDDNVMltrGVVKMLAavr
 || ... ||  .||| | |  ...... |  |.  . ...    .|.. .||   .      . |||. |..|.|||||.|  ...    .....    
ivmlgqkvekleekceeylpvkisekldigrfkikiknkelilnkkiskrtlevedstgkfatrtvthyqysewtdrgvPkshaelf...dlmelvk...

rhriqtdKATSPLLVHCSAGVGRTGCFVLIDQCFRLLEHNQRLDLAALIKENRRYRMAFVQTPEQFefAWRTV
       |.  |..||||||.||. .|.  .   | .| .....|.  .|. |  |   ||| .|.   | |.
.......ksekPivvhcsaGiGrsvafigteylareveadptieltealkhlrehrwngvqtnsql..ywmtl
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 35-104 5.1e-15 50.3 In-house 12-81 (250) alignment 
Range on Protein: 35-104
Range on HMM: 12-81/250.0
YNRYNDILPSPASRVILPEERGDPATTYINANYLPFLGNPKAYIAAMGPLPTTIHSFLRMVIEHKTVAMV
 ||| ||..   |||.| .|.||  . |||| .|    . ||.||. |||..||  | |||.|.|. ..|
knryadiialdssrvvLekekgdkesdyinasflhgyderkafiatqgPlqatiedfWrmvleeksgtiv
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 136-307 6.8e-15 49.5 In-house 114-294 (301) alignment 
Range on Protein: 136-307
Range on HMM: 114-294/301.0
VMTTNFEEKGRKKCECYWPELPQDTMEFGDIKVFNEGQQQEQFFRITRLR--LERGG---------------TIHRVTHFFYNTWPDRGVPRSDDNVMlt
|| || .|. ..||| |||.  ... ||| ..|    .|    | | .|   .. |                . . |. .    ||. || |    |.  
vmvtnlkegtkskceqywpnseaeseefgpftvtlvneqvyPdfvirqlnvkiqdgsnngyierkfkvksdksswdvlqlqvtdWpqdGvvreprtvL..

rgvvKMLAAVRrHRiQTDKATSPLLVHCSAGVGRTGCFVLIDQCFRLLEHNQRLDLAALIKENRRYRMAFVQTPEQFEFAWRTVAGYIN
    . .  |  || |     .|..||||..|.|.| .. ..        .   |.  ..|  || ..  |.| ||. . .  .  |..
....qviddvi.hr.qqkigggpvvVHCSdtVsrsGvYcsvsiglEQckaegVVdvfqvtkavrrskpgaVtTLeqytsiydvidmylq
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 36-103 1e-14 49.1 In-house 42-108 (287) alignment 
Range on Protein: 36-103
Range on HMM: 42-108/287.0
NRYNDILPSPASRVILPEErGDPATTYINANYLPFLGNPKAYIAAMGPLPTTIHSFLRMVIEHKTVAM
||| |.||   .||.| .| |.  . ||||||..   . .|.||| ||...|. .| |.|.|... ..
nryadvlPiddtrvllsae.gelGsdyinanyvasytddeafiaaqgPiaatvrdfwravletrsasv
subfamily_Ptp69D_pd Subfamily Ptp69D 34-104 1.4e-14 48.9 In-house 50-120 (307) alignment 
Range on Protein: 34-104
Range on HMM: 50-120/307.0
VYNRYNDILPSPASRVILPEERGDPATTYINANYLPFLGNPKAYIAAMGPLPTTIHSFLRMVIEHKTVAMV
. |||.|| .    ||.|..  |.  ..||||...    . | .||| .|. .||. | ||. | .   .|
lknRyedikafDktRvkLkkingkedsdYinasfikgykekkkfiaaqdPveatigDfWRmiaeqevtliv
subfamily_PTPN9_pd Subfamily PTPN9 36-104 1.9e-14 48.4 In-house 46-114 (297) alignment 
Range on Protein: 36-104
Range on HMM: 46-114/297.0
NRYNDILPSPASRVILPEERGDPATTYINANYLPFLGNPKAYIAAMGPLPTTIHSFLRMVIEHKTVAMV
|||.|.|    .|| |... .|.|. |||||..    ..||.||. |||. |.. | ||| |.... .|
nrytdvlcydetrvvlakvdedeasdyinanfvdGykqkkafiatqGplkktvsdfWrmvWeqevlviv
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 35-104 2.3e-14 48.1 In-house 52-121 (315) alignment 
Range on Protein: 35-104
Range on HMM: 52-121/315.0
YNRYNDILPSPASRVILPEERGDPATTYINANYLPFLGNPKAYIAAMGPLPTTIHSFLRMVIEHKTVAMV
 ||| .|..   ||| ||    || . |.|||...    .. |||| ||...... | |.| |..   .|
knryiniiaydksrvqlpllendphsdyvnanfidGynkkrryiaaqgpnvasvkdfwrlvfeedigkiv
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 36-105 2.5e-14 47.3 In-house 47-118 (515) alignment 
Range on Protein: 36-105
Range on HMM: 47-118/515.0
NRYNDILPSPASRVILPEERGDPATTYINANYLPFLGNPKAYIAAMGPLPTTIHSFLRMVIEHK--TVAMVC
|||..|||   .||.|     .|   |.|| |.| . | |||||. ||.....  | |.|....  |.||| 
nryknilPydsvrvklevindnPhsdyfnasyipsfdndkayiasqgPnkasvddfWrlvlqenvttiamvt
subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 135-307 2.6e-14 47.6 In-house 110-277 (312) alignment 
Range on Protein: 135-307
Range on HMM: 110-277/312.0
QVMTTNFEEKGRKKCECYWPELpQDTMEFGDIKVFNE--------GQQQ-EQFFRITRLRLERGGTIHRVTHFFYNTWPDRGVPRSDDNVMltrgvvKML
 .. . | | | .||  |  ..    ... | .|. |        |. .     |. .. .   |   .. |. . .||| |.| | |  .      ..|
iillcgfvedgsekcakyisdi.vgfvdledhrvyteycteieiggkskdkithrvlkvvvkatgqesklnhyqwaswpdhgmpdscdtal......rll

AAVRRhriqtDKatSPLLVHCSAGVGRTGCFVLIDQCFRLLEHNQRLDLAALIKENRRYRMAFVQTPEQFEFAWRTVAGYIN
.||..     ||   |.. |||||||||| ..||.     | | .. ..       |. |   |..  |. .| |.|  .. 
savkk.....dk..kpviahcsagvgrtgtlaliesmiaalrhprkqnvkdsfvllrkdrarsvrvfpqyvyalrcvlefly
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 35-105 2.9e-14 47.6 In-house 47-119 (315) alignment 
Range on Protein: 35-105
Range on HMM: 47-119/315.0
YNRYNDILPSPASRVILPEERGDPATTYINANYLPFLGNPKAYIAAMGPLPTTIHSFLRMVIEHK--TVAMVC
 |||..|||   .||.|     .|   |||| |.. . . |||||. |||....  | |||...|  |..|| 
knryknilPldsarvkleviddsPdsdyinasyiksvdddkayiasqgPlkasvddfwrmvlqekvttivmvt
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 29-104 7.8e-14 46.4 In-house 44-119 (288) alignment 
Range on Protein: 29-104
Range on HMM: 44-119/288.0
YARGRVYNRYNDILPSPASRVILPEERGDPATTYINANYLPFLGNPKAYIAAMGPLPTTIHSFLRMVIEHKTVAMV
 |.    |||..|||    || | .    . . ||||.|.   .. |.|||. |||. |.. | ..| |.||  .|
lavnakknRyrnilpyDekrvklkkleeeagaDYinasyidgekkkkkyiatqgPladtvndfWelvyenktstiv
subfamily_PTPRG_pd Subfamily PTPRG 34-104 1.3e-13 45.1 In-house 49-120 (563) alignment 
Range on Protein: 34-104
Range on HMM: 49-120/563.0
VYNRYNDILPSPASRVILPEERGDPAT-TYINANYLPFLGNPKAYIAAMGPLPTTIHSFLRMVIEHKTVAMV
  ||| .|...  ||| | .  |   .  ||||||.      ||.||. |||..|.. | ||. |...  .|
rKnRylnivaydrsRvklsplpgkkkklDYinAnyidGyqkskafiatqgplkdtfddFWrmiWeqnvaiiv
subfamily_PTPRK_pd Subfamily PTPRK 34-104 1.9e-13 44.9 In-house 45-115 (314) alignment 
Range on Protein: 34-104
Range on HMM: 45-115/314.0
VYNRYNDILPSPASRVILPEERGDPATTYINANYLPFLGNPKAYIAAMGPLPTTIHSFLRMVIEHKTVAMV
  ||..|||.   |||.|    ||| . ||||...    .|.|.|.. |||. |.. | |.| .... ..|
eknrsgdilaydrsrvflitidgdpssdyinaalidsykrpaafivtqgPlqetvkdfWrlvydencasiv
subfamily_egg_pd Subfamily egg 46-304 4e-13 43.7 In-house 54-268 (307) alignment 
Range on Protein: 46-304
Range on HMM: 54-268/307.0
ASRVILPEERGDPATTYINANYLPFLGNPKAYIAAMGPLPTTIHSFLRMVIEHKTVAMVCP--RSPPpqsvsaihcppnmrrlpcltmftrqvmttnfee
 ||| |  .||  .  .| ||..        .| |  ||  | . | ||| . .   .|    |  .                                 
ssrvklelrrGqylddfihanrvkGkpllnefilaqaplkntvddfwrmvfqeevqyivmltsrkes.................................

kgrKKCECYWPELPQDTMEF--GDIKV--FNEGQQQEQFFRITRLRLeRGGTihrvthffyntWPDRGVPRSDDNVMLTRGVVKMLAAVRRHRiqtdKAT
   ..|| |||  ..|.. .  | ...  ..  .. . .||.|.|.|  ||              .| .     .|  .  |   |  .|. |    ...
...erceyywpkaesdslvtvpGslrienlkvdskadplfrvtklkl.vGgd...........deerflehwqgdvnnssdvysplrvlrklr....nls

SPLLVHCSAGVGRTGCFVLIDQCFR-LLE-HNQRLDLAALIKENRRYRMAFVQTPEQFEFAWRTVAG
 | .|..  || .....| |.  .  ||     .  .   ..  |. |   |... .. | .| |. 
kpvvvqdilGvskaatlvaieiallsllrGpitkslvlravvflrlrrrlsvesvllylfvyrlvlf
subfamily_CG42327_pd Subfamily CG42327 232-307 4.2e-13 43.6 In-house 240-316 (319) alignment 
Range on Protein: 232-307
Range on HMM: 240-316/319.0
RIQTDKATSPLLVHCSAGVGRTGCFVLIDQCFRLLEHN-QRLDLAALIKENRRYRMAFVQTPEQFEFAWRTVAGYIN
|  | .   || |||| ||||||  .  |  .| ||.. . .|.  |.   || |   |.| ||.|| ....  | .
rsgtresqGPlvvhcsdGvGrtGlviasdiairsleeskrsvdiPqlvssvrrdrasavltkeqyefiykvlseyak
subfamily_eak_pd Subfamily eak 142-313 4.7e-13 43.2 In-house 128-312 (332) alignment 
Range on Protein: 142-313
Range on HMM: 128-312/332.0
EEKGRKKCECYWPELPQDTMEFGDIKVFNEGQQQEQFFRITRLRLERGGTIHRVTHFFYNTWPDRGVPRSDD-----NVMLTRGVVKMLA-------AVR
 |.. .| . |.|.  .. ..|| ..|      ... ..   | |..|   ||| |. .  | .  .|. .|     .||   ||....        .. 
velkleksdkyfpdktreelkfGildverkefvkrniletrllelskGnethrvlhykvfGwtettlpkyedflalrkvmkevGvlllivmksallsstl

RHRIQTDKATSPlLVHCSAGVGRTGCFVLIDQCFRLLEHNQR--LDLAALIKENRRYRMAFVQTPEQFEFAWRTVAGYINFRLKTM
.. | |  . .| .. .. |  |.| ||.||   ||.. ...    .  ||   .  |.  | .  |  | .  |  |.  | . .
kkyihtppsfap.iiqsarGsaraGvfvvidllirlidnkkknlysvedlilkvkskrihsvlvalqhsfiyeivldyllrrnnrl
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 194-309 6.8e-13 43.1 In-house 216-347 (350) alignment 
Range on Protein: 194-309
Range on HMM: 216-347/350.0
RVTHFFYNTWPDRGVPRSDDNVMLTRGVVK-MLAAVRRHRIQTDKATSPLLVHCSAGVGRTGCFVLIDQCFR-------LLEHNQRLDLAA--------L
 | .. .. |.| ..     ... .  | . ..     .    .. .||.|||||||||||| .| .|. .        | .. ..|| ||        .
vvyqlqvknWkDlslllnPesilqalevkndliddlfaeshldnarsspilvhCsaGvGrtGtlvtlDsllsdfeilenltkesrkldvaaktrDlisii

IKENRRYRMAFVQTPEQFEFAWRTVAGYINFR
..| |. |.  ||. .|| | . ..  | . |
vnelrkqrismvqnldqfifiYeallfyfaLr
0037934 (Phosphotyrosine protein) phosphatases II 33-108 1.2e-12 43.4 In-house 11-83 (243) alignment 
Range on Protein: 33-108
Range on HMM: 11-83/243.0
RVYNRYNDILPSPASRVILpeergDPaTTYINANYLPFLGNpkaYIAAMGPLPTTIHS----FLRMVIEHK--TVAMVCPRS
.  ||| |||| . |||.|     .. . |||||. . ...   .||  |||| |...    |.||. |..  .. |...  
lsknrysdilpydhsrvkl.....eg.sdyinanliyvtpr...liatqgPlpetveddlasfwrmlwelgitvivmltelv
subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 137-298 1.7e-12 41.6 In-house 124-282 (310) alignment 
Range on Protein: 137-298
Range on HMM: 124-282/310.0
MTTNFEEKGRKKCECYWPELPQdTMEFGDIKVFNEGQQQEQFfRITRLRL----------ERGGTI--HRVTHFFYNTWPDRGVPRSDDNVMltrgVVKM
.  .  |.|| ||  ||| |   |  .| |.| | ..  |.|  |  | .          |.   .   ||.   .  |||||||      .      ..
llckvgeegrpkcvgywpslgv.tetygcirvtnlsesseef.eicnlavtfvpdnvpvdeqpanlkelrvslikwpnwpdrgvpdekchtv....pqrl

LAAVRrHriqtdkatSPLLVHCSAGVGRTGCFVLIDQCFRLLEHNQRLDLAALIKENRRYRMAFVQTPEQFEFA
|| || |         | .||||||..|... | ..  .  |.. ...|.  .. | .. |.  .||. |. . 
laqvr.h........gpcvvhcsagkdrlyvvvalklkidkldrglkvdaeevktellksraiciqtelqylii
subfamily_PTPN6_pd Subfamily PTPN6 35-103 2.3e-12 41.5 In-house 57-126 (306) alignment 
Range on Protein: 35-103
Range on HMM: 57-126/306.0
YNRYNDILPSPASRVILPeERGDPATTYINANYLP--FLGNPKAYIAAMGPLPTTIHSFLRMVIEHKTVAM
 |||. |||   .||||  | . | ..||||||.   . |. |.|||. | |.||.  | ||| . ..  .
knryknilPfDhtrvilk.epsvpgsdyinanyikkevkgsdksyiatqgclettvsdFWrmvwqensrvi
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 34-104 4.4e-12 40.8 In-house 48-118 (305) alignment 
Range on Protein: 34-104
Range on HMM: 48-118/305.0
VYNRYNDILPSPASRVILPEERGDPATTYINANYLPFLGNPKAYIAAMGPLPTTIHSFLRMVIEHKTVAMV
  ||...| . . .|.|| |.  .. . ||||.|.    . |.||.| |||..|.. | |...| |.. .|
aknrlkeitlldddriiltekeslddsdyinasyvdgykrkkkyivaqgPlkntvadfWrliveekvstiv
subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 135-312 6.1e-12 40.3 In-house 95-261 (290) alignment 
Range on Protein: 135-312
Range on HMM: 95-261/290.0
QVMTTNFEEKGRK----KCECYWPELPQDTMEFGDIKVFNEGQQQEQFFRITRLRLERG-GTIHRVTHFFYNTWPDRGVPRSddnvmlTRGVVKMLAAVr
 ||. .|||| ..     |. | ||   . . |....|    . .|. . . .| .. . .  . |||  .. | .. |...      |. .....  | 
vVmlcefeeksantslfaCakYvpesvgeelkfkgltvkCkskekeddvetRelvvkfddeeeftvtHsllkgWnklnvqed......tktllsliqkv.

rhriQtdKATSPLLVHCSAGVGRTGCFVLIDQCFRLLE-HNQRLDLAALIKENRRYRMAFVQTPEQFEFAWRTVAgyinFRLKT
    .  . ..| .|||  |. |  ..  |.  . ..   .. . |....|. |. |   ....... |.   .     .... 
....k..asktpvivHcvdGiSrsAalaaiilgyQkiaetsgsvkledvlkalrkqralaitsalelafvdagiv....llaie
subfamily_PTPN13_pd Subfamily PTPN13 33-104 7.8e-12 40.0 In-house 38-108 (273) alignment 
Range on Protein: 33-104
Range on HMM: 38-108/273.0
RVYNRYNDILPSPASRVILPEERGdpattYINANYLPFL--GNPKAYIAAMGPLPTTIHSFLRMVIEHKT--VAMV
.  ||| ..||  ..||.| .| |     ||||...      .   |||. ||||.|.. | .|| | |.  .|||
kdknryrnvlPydetrvklgdegg.....yinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweqkaeviamv
subfamily_PTPN1_pd Subfamily PTPN1 32-104 1.9e-11 38.2 In-house 32-100 (290) alignment 
Range on Protein: 32-104
Range on HMM: 32-100/290.0
GRVYNRYNDILPSPASRVILPEERGdpatTYINANYLPFLGNPKAYIAAMGPLPTTIHSFLRMVIEHKTVAMV
 |  ||| |. |   ||..| ..       ||||. . .    . || . |||| |.  | .|| |.|. |.|
nrnlnryrdvspydhsrikleradn....dyinaslveleeakrsyiltqGPlpntvdhfWqmvWeqkskavv
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 36-104 2.4e-11 38.3 In-house 55-123 (297) alignment 
Range on Protein: 36-104
Range on HMM: 55-123/297.0
NRYNDILPSPASRVILPEERGDPATTYINANYLPflGNPKAYIAAMGPLPTTIHSFLRMVIEHKTVA--MV
.||..|||.  |||.|     ||   |.|| ...  || . .|.   | ..|.  | .||..... .  |.
sRYkniLPydssRvkLaivnddpdsDyvnasfvk..gnkhrlittqmPmkatvadfWamvldeqvstivml
subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 137-305 2.8e-11 37.9 In-house 105-269 (285) alignment 
Range on Protein: 137-305
Range on HMM: 105-269/285.0
MTTNFEEKGRKKCECYWPELPQDTMEFGDIKVFNEGQQQEQF-----FRITRLRLERGGT-IHRVTHFFYNTWPDRGVPRsDdnvmlTRGVVKMLAAVRR
|   . | | .||  |.||   . ..||  ..     ..|         .| .  |   .    . |     |||.  |  |     .| ....   |..
mlctlfeggvekcalyypeklgevvkfgkyeitlteckeeaiagtilnaltvintedasseplymnhvqvpwwpdqlape.d.....arpmielykwvkk

hriqTDKATSPLLVHCSAGVGRTGCFVLIDQCFRLLEHNQRLDLAALIKENRRYRMAFVQTPEQFEFAWRTVAGY
     .    |. ||||||||||  || || .   .  |  ...  ...| |  |.  ||.  || | .  .  |
....vnpkekpicvhcsagvgrtatfvgidyatirimenpniemldivremramrfqavqshmqflflyvvlmey
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 35-104 3.1e-11 37.4 In-house 51-120 (439) alignment 
Range on Protein: 35-104
Range on HMM: 51-120/439.0
YNRYNDILPSPASRVILPEERGDPATTYINANYLPFLGNPKAYIAAMGPLPTTIHSFLRMVIEHKTVAMV
 |||.|. .   .||.| |  | | . ||||||.    ..| |||. ||   | ..| |.|||.||| .|
knrykdvgafdhtrvtlqeipgvphshyinanyikGyyddklyiatqgpkkettddfwrlviekktvtiv
subfamily_PTPN3_pd Subfamily PTPN3 35-103 1.2e-10 35.8 In-house 44-112 (280) alignment 
Range on Protein: 35-103
Range on HMM: 44-112/280.0
YNRYNDILPSPASRVILPEERGDpattYINANYLPFLGNP----KAYIAAMGPLPTTIHSFLRMVIEHKTVAM
 ||| ||||  | ||.| |.. |    ||||||. .  .     . |||. |||..| . | .|| |.|.  .
knryrdilpydatrvklkesetd....yinanyvnmeipstglvnryiatqGPlaktatdfWqmvweqkssli
subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 192-296 1.3e-10 35.2 In-house 187-278 (302) alignment 
Range on Protein: 192-296
Range on HMM: 187-278/302.0
IHRVTHFFYNTWPDRGVPRSDDNVMltrGVVKMLAAVRRHriqtdkatspLLVHCSAGVGRTGCFVLIDQCFRLLEHNQRLDLAALIKENRRYRMAFVQT
 . |  . . .||| | |.  .. .    ..|   . ..           .|||||||||||| .| |     |  ...  ||. ...  |. |   ||.
kktvdilafsawpdhGapkeaytal...dilkfcesykkn..........vlvhcsaGvGrtGtlvaikyGiqlcskkkvtdllsivlpvrqcryGavqd

PEQFE
 .|  
eqqli
subfamily_CG7180_pd Subfamily CG7180 35-105 1.7e-10 35.1 In-house 45-115 (296) alignment 
Range on Protein: 35-105
Range on HMM: 45-115/296.0
YNRYNDILPSPASRVILPEERGDPATTYINANYLPFLGNPKAYIAAMGPLPTTIHSFLRMVIEHKTVAMVC
 ||. ...|    ||.|..  |.  . |||| |   .  .|.||   .|   |...| |.| .... |.| 
knrdvkvvPyDynRvvLekldGeeksdYinavyvdsflkkkeyivteapkketvdefWrlvydeeisavvv
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 35-105 2.1e-10 35.1 In-house 44-114 (307) alignment 
Range on Protein: 35-105
Range on HMM: 44-114/307.0
YNRYNDILPSPASRVILPEErGdPATTYINANYLPFLGNPKAYIAAMGPLPTTIHSFLRMVIEHKT--VAMVC
 |||.|.     .|...  . |  |. || ||||    .|| .|.| ||| .|..||  |.|..|   | |.|
knryqdvkcqdkgrivvkfd.g.lasdyihanylgiaikpkkficaqgplentqysfwamaiqekvesvimlc
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 35-101 8.8e-10 32.8 In-house 50-130 (350) alignment 
Range on Protein: 35-101
Range on HMM: 50-130/350.0
YNRYNDILPSPASRVILP--------EERGDPATTYINANYLPFL-----GNPKA-YIAAMGPLPTTIHSFLRMVIEHKTV
 |||..|||   |||.|.         .    .  |||||||         ||.  |||. .||| |.. | ..... |  
knrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvk
subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 140-297 1.1e-09 32.7 In-house 36-194 (198) alignment 
Range on Protein: 140-297
Range on HMM: 36-194/198.0
NFEEKGRK-KCECYWPELPQDTMEFGDIKVFNEGQQQEQFFRITRLRLERGGTI----HRVTHFFYNTWPDRGVPrsddNVMLTRGVVKMLAAVRRHRIQ
| ..| ..     |||     | ..| . |  .    .  . || | |    |       ..|. . .| ..  |    || |  | |     | ..  |
nddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqftswkekttp....nvalfvgfvvasrevskkyeq

TDkaTSPLLVHCSAGVGRTGCFVLIDQCFRLLEHNQ--RLDLAALIKENRRYRMAFVQTPEQFEF
     .|..|||| | | || || .|   |  |  .   .||  . |  |. |   . . ....|
ek..dapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynf
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 32-104 1.2e-09 32.8 In-house 3-74 (237) alignment 
Range on Protein: 32-104
Range on HMM: 3-74/237.0
GRVYNRYNDILPSPASRVILPEERGDpaTTYINANYL-PFLGNPKAYIAAMGPLPTTIHSFLRMVIEHKTVAMV
 .. ||| .|     |||.|    ..  . ||||.||  | | || |||| ||| .. . | .|| . |   .|
nkiknrygnivaydhsrvvlkgagsg..sdyinatylkgfdgtpkkyiaaqgplesscddfwqmvwqekcsviv
subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 140-297 1.2e-09 32.7 In-house 37-195 (199) alignment 
Range on Protein: 140-297
Range on HMM: 37-195/199.0
NFEEKGRK-KCECYWPELPQDTMEFGDIKVFNEGQQQEQFFRITRLRLERGGTI----HRVTHFFYNTWPDRGVPrsddNVMLTRGVVKMLAAVRRHRIQ
| ..| ..     |||     | ..| . |  .    .  . || | |    |       ..|. . .| ..  |    || |  | |     | ..  |
nddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqftswkekttp....nvalfvgfvvasrevskkyeq

TDkaTSPLLVHCSAGVGRTGCFVLIDQCFRLLEHNQ--RLDLAALIKENRRYRMAFVQTPEQFEF
     .|..|||| | | || || .|   |  |  .   .||  . |  |. |   . . ....|
ek..dapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynf
subfamily_CG42327_pd Subfamily CG42327 23-109 1.6e-09 31.9 In-house 21-106 (319) alignment 
Range on Protein: 23-109
Range on HMM: 21-106/319.0
LDAIPPYARGRvyNRYNDILPSPASRVILPEERGDPATTYINANYLP-FLGNPKAYIAAMGPLPTTIHSFLRMVIEHKTVAMVCPRSP
 |..|. .. .  .|. ...| | .||.|..   |. . |..|.|.  .   |  ||||  .|  .  .| |.| | ..  .|.  ..
adevPvtskdk..srvinvvPlPetrvvlqrigdddkdeyldasyvrGyddapnsyiaaqvsledsssdfwrtvweqqsrvivqltdl
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 34-105 1.6e-09 32.2 In-house 49-118 (287) alignment 
Range on Protein: 34-105
Range on HMM: 49-118/287.0
VYNRYNDILPSPASRVILPeergDPATTYINANYLPFLGNPKAYIAAMGPLPTTIHSFLRMVIEHKTVAMV--C
  ||...||.    ||.|     .    |||| ..    . ||.|.| .|.  |.  | ... ...  |.|  |
dknRltqilvpdnyrvllk....gehpdyinavfidgykekkafiiaesPmfntarnfWkliddrnvtaivmlc
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 34-104 2.2e-09 31.8 In-house 10-81 (239) alignment 
Range on Protein: 34-104
Range on HMM: 10-81/239.0
VYNRYNDILPSPASRVILPEERGDPATTYINANYLP-FLGNPKAYIAAMGPLPTTIHSFLRMVIEHKTVAMV
  ||| .|.    |||.| .   || . ||||.||  . |.||||||. | . ..   | ||. . . . .|
aknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcviv
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 34-104 2.2e-09 31.8 In-house 9-80 (239) alignment 
Range on Protein: 34-104
Range on HMM: 9-80/239.0
VYNRYNDILPSPASRVILPEERGDPATTYINANYLP-FLGNPKAYIAAMGPLPTTIHSFLRMVIEHKTVAMV
  ||| .|.    |||.| .   || . ||||.||  . |.||||||. | . ..   | ||. . . . .|
aknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcviv
subfamily_PTPN23_pd Subfamily PTPN23 35-107 3.4e-09 30.9 In-house 46-115 (288) alignment 
Range on Protein: 35-107
Range on HMM: 46-115/288.0
YNRYNDILPSPASRVILPEERGDpattYINANYLPFLGN-PKAYIAAMGPLPTTIHSFLRMVIEHKTVAMVCPR
 ||..||||   .|| | ... |    |||| ..  |      .||. .||..|.  | .|| | |.  .|.  
knrsrdilPyDhnRvklrgskDD....YinAsfvkdlspgcPdfiatqaPlqstlnDFWlmvyeqkssviVmll
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 32-104 5e-09 30.5 In-house 33-104 (283) alignment 
Range on Protein: 32-104
Range on HMM: 33-104/283.0
GRVYNRYNDILPSPASRVILPEERGdpatTYINANYLP---FLGNPKAYIAAMGPLPTTIHSFLRMVIEHKTVAMV
 . .||...|.|    || |  |      .|||| ..|      . | ||.| .||  |.  | .|| ..| .|.|
nkrknrnqeivpadqwrvelksesr....dyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfdekitaiv
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 230-272 6.2e-09 29.6 In-house 257-302 (349) alignment 
Range on Protein: 230-272
Range on HMM: 257-302/349.0
RHRIQTDKaTSPLLVHCSAGVGRTGCFVLIDQCFRLLEHNQ----RL
|  ..||. .|.|||||||| |||| .| .|  . .||  |    ..
rlyldtdq.lstllvhcsaGcGrtGvlvtldlllsileplqnesnki
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 35-104 6.4e-09 30.1 In-house 36-107 (297) alignment 
Range on Protein: 35-104
Range on HMM: 36-107/297.0
YNRYNDILPSPASRVILpeERGDPATTYINANYLPFLGNPK--AYIAAMGPLPTTIHSFLRMVIEH--KTVAMV
 |||.|||    .|| |   |. . . ||||.|. |  ...   || | ||| .|.. | ..| |.  ....||
knryrdilatddtrvkl..lrviterdyinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmv
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 13-104 7.3e-09 29.7 In-house 21-114 (301) alignment 
Range on Protein: 13-104
Range on HMM: 21-114/301.0
YTRLDLQQPSLDAIPPYARGRVYNRYNDILPSPASRVILPEERG--DPATTYINANYLPFLGNPKAYIAAMGPLPTTIHSFLRMVIEHKTVAMV
|..|. ...    .    . ...||...| . .  |.|| ...      ..||||.|.    . |..||| ||.  |.  | |.....|.|..|
ykelkegedksctvglseenkalnrfknitvyddnriilkpkpnldlcqreyinasyidgysekkkfiaaqgpmkktlvdfWrliwqekpvsiv
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 34-104 9.5e-09 29.5 In-house 48-120 (290) alignment 
Range on Protein: 34-104
Range on HMM: 48-120/290.0
VYNRYNDILPSPASRVILP--EERGDPATTYINANYLPFLGNPKAYIAAMGPLPTTIHSFLRMVIEHKTVAMV
  ||...|...   |..|    .. | .  |||| |.    . |.|||. ||.. |.  | ... ..|. ..|
llnRfanivvyddnritLrpisghkDCtneyinAcyikgykekkqyiatqgpvsntlvdFWkliwqekvtiiv
subfamily_PTPN14_pd Subfamily PTPN14 36-102 1e-08 29.5 In-house 53-120 (300) alignment 
Range on Protein: 36-102
Range on HMM: 53-120/300.0
NRYNDILPSPASRVILPEERGDpATTYINANYLP--FLGNPKAYIAAMGPLPTTIHSFLRMVIEHKTVA
||..|.||   .|| |   . .  | ||||  .     |. . ||.| |||..|.. | .|| |...  
nrfkdvlPyednrvelsptken.stgyinassikvsvggkersyivaqgPleltvqdfWqmvWeqgvql
subfamily_CG42327_pd Subfamily CG42327 136-216 2.4e-08 28.0 In-house 101-184 (319) alignment 
Range on Protein: 136-216
Range on HMM: 101-184/319.0
VMTTNFEEKGRKKCECYWPE--LPQDTMEFGDIKVFNEGQQQEQFFRITRLRLER--GGTIHRVTHFFYnTWPDRGVPRSDDNVM
|  |.  |.| |.|  |.|     ..|  .|||.|   |.. .. . |. | | |  .     .||..|  |.. .|| ..  ..
vqltdlselGikvcaeylPtketldntslyGdilvtlkgrevkdryaistlllkrvdkeesrelthywy.kwleaevPaeeaali
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 11-104 7.8e-08 26.3 In-house 34-127 (305) alignment 
Range on Protein: 11-104
Range on HMM: 34-127/305.0
ASYTRLDLQQPSLDAIPPYARGRVYNRYNDILPSPASRVILPEERgdpATTYINANYLPFLG-NPKAYIAAMGPLPTTIHSFLRMVIEHKTVA--MV
| ||| |. |  ..|          |||.|.     | | | .      . || |||.       | .|.| |||  ||  |  |||..|     |.
akytrpdmtqvafnanqsadiaitknryqdvpcqdqsavkldkps...psdyihanyvgcpmipekrficaqgpldqtidefwwmviqnkveqivml
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 35-99 1.3e-07 25.3 In-house 51-131 (349) alignment 
Range on Protein: 35-99
Range on HMM: 51-131/349.0
YNRYNDILPSPASRVILPEERGDPA--------------TTYINANYL--PFLGNPKAYIAAMGPLPTTIHSFLRMVIEHK
 |||.||||   |||.|..    ..                |||||||  . .   | ||| . |||.|.. |.....  .
knrykdilPyehsrvklkkslksskvikastsesdsgklddyinanylkltrisvekkyiatqaPlPstvddfykvillng
subfamily_PTPRN_pd Subfamily PTPRN 35-104 1.8e-07 25.2 In-house 59-129 (297) alignment 
Range on Protein: 35-104
Range on HMM: 59-129/297.0
YNRYNDILPSPASRVILPEERGDPATTYINANYLPFL-GNPKAYIAAMGPLPTTIHSFLRMVIEHKTVAMV
 ||....||   ||| | ||  .  . ||||  .        ||||. |||..|. .| .|| |. .| .|
knrskavlpydhsrvklkeeasaeksdyinasaildhdprapayiatqgplastvadfwqmvweqGvvviv
subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 12-101 4.6e-07 23.7 In-house 32-120 (310) alignment 
Range on Protein: 12-101
Range on HMM: 32-120/310.0
SYTRLDLQQPSLDAIPPYARGRVYNRYNDILPSPASRVILPEERGDpATTYINANYLPFLGNPKAYIAAMGPLPTTIHSFLRMVIEHKTV
 | .|| .| |  .   | .    ||| |..   .||| |  ..      || |||.      ...| . |||  ||  | ||... .. 
qyrkldakqdssltyeaykkymhknrysdvvcldtsrvklkidksr.yedyihanyvktnylrstficsqgplqhtiidfwrmifqerae
subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 37-104 5.1e-07 23.5 In-house 42-114 (347) alignment 
Range on Protein: 37-104
Range on HMM: 42-114/347.0
RYNDILPSPASRVILPE-----ERGDPATTYINANYLPFLGNPKAYIAAMGPLPTTIHSFLRMVIEHKTVAMV
| .|     |.||.|        | |.. ||||| .. |    | || .  ||| |.  | .||   |   .|
rskdvklidatrvvlspeksknsraddvetyinashikfdnaskeyiltqyplpdtvrdfwkmvsvtkvtqvv
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 35-104 6.3e-07 23.3 In-house 59-123 (290) alignment 
Range on Protein: 35-104
Range on HMM: 59-123/290.0
YNRYNDILPSPASRVILPEerGDPaTTYINANYLPflGNPKAYIAAMGPLPTTIHSFLRMVIEHKTVAMV
 ||| |.     .|||| .  | .   |. |||.   |    .| . |.|  |.  . |||...|. |.|
knrykdvvcndktrvilkd..Gyd.Gdyvhanyvk..GlkamfiltqGalkdtvidiwrmvlqekvaaiv
SH3_1 SH3 domain 372-405 9.1e-07 17.5 Pfam-A 10-46 (48) alignment 
Range on Protein: 372-405
Range on HMM: 10-46/48.0
HDDTLSFQAGMRCILMEKSEH-WWRVSMR--NQDGWV
..| |||. |  .|. ||||. ||..  .  .. |..
esdELsfkkGDviivleksedgWwkgrlkgtgkeGli
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 35-104 1.1e-06 22.8 In-house 36-101 (267) alignment 
Range on Protein: 35-104
Range on HMM: 36-101/267.0
YNRYNDILPSPASRVILPEERGDpattYINANYLPFLGNPKAYIAAMGPLPTTIHSFLRMVIEHKTVAMV
 ||..| ||   .|||| ..  .    |||| |.      .|.|.  .||  ||  || .....|   .|
rnrlddnlpyddtrvilrtkeee....yinasyvegyktknafivtqdplkntitdfltvihdqkvpviv
subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 202-316 2.6e-06 21.1 In-house 190-295 (302) alignment 
Range on Protein: 202-316
Range on HMM: 190-295/302.0
TWPDRGVPRSDDNvmLTRGVVKMlaavrrhRIQTDKATSPLLVHCSAGVGRTGCFVLIDQCFRLLEHNQRLDLAALIKENRRYRMAFVQTPEQFEFAWRT
 |..  || .  .  |.. ..|.         .. ||......    |.|| | |.   . .  |....    . ..|  |  | . |.. .|. . ...
nWkqkkvpvkyae..liktaakv.......fakkikadentvivSknGaGRagafltlavaveklqkgkepnikeivksiRsqRpravdslkQyvslyia

VAGYINFRLKTMAQA
.. ||  .... .. 
lllyikkkvtkpeek
subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 61-106 3e-06 21.2 In-house 76-123 (301) alignment 
Range on Protein: 61-106
Range on HMM: 76-123/301.0
TYINANYLPFLGNPKAYIAAMGPLPTTIHSFLRMVIEHK--TVAMVCP
  | ||..|  |.|. .||. |||. | . |  |.. ..  ...|.. 
vPihanwiptsGhphrfiatqgPlkntsedfwamlvqydvekivmlgq
subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 198-306 6e-06 20.1 In-house 176-279 (303) alignment 
Range on Protein: 198-306
Range on HMM: 176-279/303.0
FFYNTWPDRGVPrSDDNVMLTRGVVKMLAAVRRHriqTdKATsPLLVHCSAGVGRTGCFVLIDQCFRLLEHNQ-RLDLAALIKENRRYRMAFVQTPEQFE
  |..||   .| || .  . . . .. . .|..   . ..| | .    .|.||.| | |.. .   |  .|  |||   ..  |  |.  ||   || 
hhykawphnsip.sdgspkfvkqiwqlqsvlrky...s.dst.ptvymslsgcgragtfalfetahlslhseqasldlvkclenvrngrlhavqnlsqfs

FAWRTVAGYI
. .  .| ..
vvytllaehv
0038934 (Phosphotyrosine protein) phosphatases II 202-296 8.6e-06 21.0 In-house 86-167 (194) alignment 
Range on Protein: 202-296
Range on HMM: 86-167/194.0
TWPDRGVPRSDDNVMLTRGVVKMLAavrrhriqTDKATSPLLVHCSAGVGRTGCFVlidqCFRLLEHnQRLDLAALIKENRRYRMAFVQTPEQFE
 .||.|.. |.....    .|.            ...    .||| ||.||||..|    .  |... ..... . |.  |. |   .......|
pfpddgtvPsleillrfldlvdefl........nedpggvvaVHCkaGlgRtGtlv....aaYLiyr.lgmsaeeAialfrekRpgaipnqdyle