Gene MbrePTP-sf2-4 in Monosiga brevicollis

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily MbrePTP-sf2
Protein sequence
ID Type Fasta BLAST phosphatome Note
MbreP042_AA protein Get Run
MbreP042_AA_13-277 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 22-278 6e-111 364.7 In-house 1-266 (270) alignment 
Range on Protein: 22-278
Range on HMM: 1-266/270.0
FQEIPLEAVDLTSIPAGVRNHKYNRYADVLPTPATRVPLAELDSDPTTAYINANFVRGAHNNKRKYIAAMAPLPATLRSWWRMIWQEQVTAIVMATPLNE
|.|.. |... ...|. .|..|.|||||.||.||||| |.||..|..|||||||.|||....|.||||||.|||.||.|.|||||.|.||||||.|.|.|
fkeldkeetsesdlpeaargkklnRyadiLPsPatRvrleeleedsataYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleE

NGTDLCSRYWAPSPGQKIKCMNMFVRTMATSDVKDKGYLRTLLQIEaEDGEKRQLMHFWMYDWN----PRNPD------SLLYCLRDMHLSEKQLAKGGP
.|.. |.|||...|..|.|.........|.|..|..||..| |..| |.||.|.|.|||...|.    ||..|      .||..||... |||.|.|..|
kgrkkCerYWpaepkekvkledgkikvlalseekeegyiltrlrle.ekgeerrlvHfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkaeP

ILVHDSAGVGRAGVIIATDFATELLESTGKADTLGIVRELRQDRMALVQTPEHYLLVQQAIRLFART
.|||.||||||.|..||.|.|..|||.|.|.|.| |..|||.|||||||.||.| ....|....|..
llvHcsaGvgRtGtlialDiavrlLeetkkvdvlaiieelRkdRmalvqhpeqyeflykavveyaer
0050432 (Phosphotyrosine protein) phosphatases II 33-277 3.3e-65 215.8 In-house 60-300 (308) alignment 
Range on Protein: 33-277
Range on HMM: 60-300/308.0
TSIPAGVRNHKYNRYADVLPTPATRVPLaeldsDPTTAYINANFVRGAH-NNKRKYIAAMAPLPATLRSWWRMIWQEQVTAIVMATPLNENGTDLCSRYW
.|. . ..|.. ||| |.||   .|| |     |... ||||..|.| . ...||.||. .||| |. ..|||.|...|. ||| | | |||   | .||
ysvallpenkdkNrykdilpydhsRVkl.....degsdYInAsyvdgyssklprkfIatqgPlpntvedFwrmvweqnvrvIvmLtklvengrekcaqYw

APSPG-QKIKCMNMFVRTMATSDvkDKGYLRTLLQIEA-EDGEKRQLMHFWMYDWNPRN-PDSLLYCLRDMHLSEKQLaKGGPILVHDSAGVGRAGVIIA
 ...| . ... ...|... .    ...| .. |...  .||| |...||.. .|   . |.|.  .|. ..| .|.| .||||.|| ||||||.|..||
plelgggsleygkftvtllseev..lddytvrtleltnlgdgesrtvthfhytnWpdhgvPpspeilldflelvrksl.pggpivVHCsaGvGRtGtfia

TDFATELLESTGKADTLGIVRELRQDRMALVQTPEHYLLVQQAIRLFAR
 | . |.|| .|. | ...|. ||. |.  |||||.||.. .|.  ...
ldllleqlekeggvdvfeavkklReqRpgmvqtpeqylflyralleylk
0046845 (Phosphotyrosine protein) phosphatases II 34-277 1.2e-64 213.7 In-house 21-275 (284) alignment 
Range on Protein: 34-277
Range on HMM: 21-275/284.0
SIPAGVRNHKYNRYADVLPTPATRVPLAELDSD-PTTAYINANFVRGAH----NNKRKYIAAMAPLPATLRSWWRMIWQEQVTAIVMATPLNENGTDLCS
|. . . |.. ||| |.||   .|| |  ||.| ... ||||..|.| .    ..|.|.||. .||| |. ..|||.|...|. ||| |.| |||   |.
svallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweqnvrvIVmltelvengrekca

RYWAPSpGQKIKCMNMFVRTMATSDvkDKGYLRTLLQIEAE--DGEKRQLMHFWMYDWN----PRNPDSLLYCLRDMHLSEKQLAKGGPILVHDSAGVGR
.|| .. |..... ...|... .    ...| .. |... .  .|| |...||.. .|     | .|..||  ||... . ..| .||||.||.||||||
qYwple.gevltygdftvtllseev..kddytvrtleltnlgytgesrtvthfhytswpdhgvppspedlleflrlvrellenlpgggpivVHCsaGvgR

AGVIIATDFATELLESTG---KADTLGIVRELRQDRMALVQTPEHYLLVQQAIRLFAR
.|..|| | . |.|| .|   . | |..|. ||. |.  |||.|.|..| .|.  ...
tGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyealleylk
0051299 (Phosphotyrosine protein) phosphatases II 34-275 1.9e-63 210.0 In-house 42-285 (288) alignment 
Range on Protein: 34-275
Range on HMM: 42-285/288.0
SIPAGVRNHKYNRYADVLPTPATRVPLAELDSDPTTAYINANFVRGaHNNKRKYIAAMAPLPATLRSWWRMIWQEQVTAIVMATPLNENGTDLCSRYWAP
|. . . |.. ||| |.||   .|| |  ||..... ||||....| .|.|||.||. .||| |. ..|||.|...|. ||| |.| |.|   | .|| .
saallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyidg.ynlkrkfIatqgPlpntvedFWrmvweqnvrvIvmltklvelgrekcaqYwpl

spGQKIKCMNMFVRTMATSDvkDKGYLRTLLQIEA-----EDGEKRQLMHFWMYDWNPRN----PDSLLYCLRDMHLSEKqlAKGGPILVHDSAGVGRAG
  |..... ...|... .    ...|  . |...       |||.|. .||....|   .    |..||  ||... . .  ..|||..|| ||||||.|
..ggsltygditvtllseev..lddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpdspellldflrlvrkala..sgggpvvVHCsaGvgRtg

VIIATDFATELLESTGKADTLGIVRELRQDRMALVQTPEHYLLVQQAIRLF
..|| | . |.|| .|. | |..|. ||. |. .|||||.|..| .|.  .
tfialdllleqlekeggvdvleavkrlreqRpgmvqtpeqyrfvyealley
0036941 (Phosphotyrosine protein) phosphatases II 34-278 2.1e-63 209.7 In-house 32-279 (297) alignment 
Range on Protein: 34-278
Range on HMM: 32-279/297.0
SIPAGVRNHKYNRYADVLPTPATRVPLaeldSDPTTAYINANFVRGaHNNKRKYIAAMAPLPATLRSWWRMIWQEQVTAIVMATPLNENGTDLCSRYWAP
|. . ..| . ||| |.|| . ||| |    .|. . ||||..| | .. |||.||. .||| |. ..|||.|...|| ||| |.| |.|   | .|| .
svallpenleknRykdilpydhtRVkl....ddegsdYinAsyvdg.ydlkrkfIatqgPlpntvedFWrmvweqnvtvIvmltelvelgrekcaqywpl

SPGQKIKCMNMFVRTMATSDVKDKGYLRTLLQIEA-EDGEKRQLMHFWMYDWNPRN----PDSLLYCLRDMHLSEKQLAKGGPILVHDSAGVGRAGVIIA
  |. ... ...|... .. | ...| .. |...  ..||.|...||.. .|   .    |.|||  .. ..   |.| .|||.||| ||||||.|..||
eegesltygdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfielvrkvlkllpsggpvlVHCsaGvgRsgtfia

TDFATELLE---STGKADTLGIVRELRQDRMALVQTPEHYLLVQQAIRLFART
 | . ..||    .|. | | .|..||. |.  |||.|.|. . .|.  . ..
adlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallellkk
0040438 (Phosphotyrosine protein) phosphatases II 22-278 3e-62 206.0 In-house 24-278 (317) alignment 
Range on Protein: 22-278
Range on HMM: 24-278/317.0
FQEIPLEAVDLTSIPAGVRNHKYNRYADVLPTPATRVPLAELDSDPTTAYINANFVRGaHNNKRKYIAAMAPLPATLRSWWRMIWQEQVTAIVMATPLNE
|....   .| .|. . . |...||| |.|| ...|| |  |..|. . ||||..| | .| |||.||. .||| |. ..|||.|...|| ||| |.| |
fedllslkldtysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyvdg.pnlkrkfIatqgPlpntvedFwrmvweqgvtvivmLtelee

NGTDLCSRYWAPspGQKIKCMNMFVRTMATSDvkDKGYLRTLLQIEA-EDGEKRQLMHFWMYDWNPRNPD-SLLYCLRDMHLSEKQLAK-GGPILVHDSA
.|   | .||    |..... ...|... .    ..|.  . |..|  .|.|.|...||.. .|   ..  |.  .|. ... ...|.. |||.||| ||
lgrekcaqYwpl..getltygdftvtllseee..lagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfleavrealedpggpvlVHCsa

GVGRAGVIIATDFATELLESTGKADTLGIVRELRQDRMALVQTPEHYLLVQQAIRLFART
||||.|..|| . . |.|| .|. |   .|.|||. |.  |||||.|  . .|.. . ..
GvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalleylkr
0047943 (Phosphotyrosine protein) phosphatases II 33-275 1.6e-61 203.6 In-house 30-271 (273) alignment 
Range on Protein: 33-275
Range on HMM: 30-271/273.0
TSIPAGVRNHKYNRYADVLPTPATRVPLaeldSDPTTAYINANFVRGaHNNKRKYIAAMAPLPATLRSWWRMIWQEQVTAIVMATPLNENGTDLCSRYWA
.|. . ..|...||| |.||   .|| |    .|... ||||..|.| .| |||.||. .||| |. ..|||.|...|. ||| |.| |.|   | .|| 
ysvallpenkdknrykdilpydhsrvkl....gdggsdyinAsyvdg.ynlkrkfiatqgPlpntvedfwrmvweqnvrviVmLtelvelgrekcaqYwp

PSPGQ-KIKCMNMFVRTMATSDvkDKGYLRTLLQIEA-EDGEKRQLMHFWMYDWN----PRNPDSLLYCLRDMHLSEKQLAKGGPILVHDSAGVGRAGVI
.. |. .... ...|... .    ...|  . |...  ..||.|. .||....|     | ...||| ......   ..| ..||..|| ||||||.|..
leggelsltygkftvtllseet..kddytvrtleltnlgtgesrtvthfhytgwpdhgvppslesllefielvrkalealpsngpvvVHCsaGvgRtgtf

IATDFATELLESTGKADTLGIVRELRQDRMALVQTPEHYLLVQQAIRLF
|| | . ..|| .|. | | .|. ||. |.  |||||.|... .|.  .
ialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrflyealley
0039614 (Phosphotyrosine protein) phosphatases II 22-275 1.4e-60 200.6 In-house 38-288 (297) alignment 
Range on Protein: 22-275
Range on HMM: 38-288/297.0
FQEIPLEAVDlTSIPAGVRNHKYNRYADVLPTPATRVPLAELDS-DPTTAYINANFVRGAHNNKRKYIAAMAPLPATLRSWWRMIWQEQVTAIVMATPLN
|.|..   .| .|| . . | . ||| |.|| . .|| |  .|. |. . ||||..| | . ..||.||. .||| |. ..|||.|...||.||| |.|.
feellslkpd.ysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfIatqgPlpetvedFwrmvweqgvtvivmLtklv

ENGTdLCSRYWAPSPGqkiKCMNMFVRTMATSDvkDKGYLRTLLQIEAeDGEKRQLMHFWMYDWN----PRNPDSLLYCLRDMHLSEKQLAKGGPILVHD
|.|   | .|| .. |   .. ...|... .    ..|| .. | ..  .|| |...||. ..|     | ....||  |. ..   ..| ||||.||| 
elgr.kcaqywpeegg...tygdftvtllkveh..ldgytvrtlevtn.ngesrtvthfqytgwpdhgvppslellleflelvrealaelpkggpvlVHC

SAGVGRAGVIIATDFATELLESTGKADTLGIVRELRQDRMALVQTPEHYLLVQQAIRLF
||||||.|..|| . . |.||..|. | | .|.|||. |.  ||||..|  ...|.. .
saGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydallel
0045450 (Phosphotyrosine protein) phosphatases II 14-275 6.9e-59 195.4 In-house 21-303 (307) alignment 
Range on Protein: 14-275
Range on HMM: 21-303/307.0
MTPDNPTLFQEIPLEAVDLT-------SIPAGVRNHKYNRYADVLPTPATRVPLAELDSD-PTTAYINANFVR-------GAHNNKRKYIAAMAPLPATL
...|..|....   . ...|       || . . |...||| |.|| . ||| |  ||.. ... ||||..||       . ...|||.||. .||| |.
llldfltgllkefekllsvtvfllgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydlkrkfIatqgPlpetv

RSWWRMIWQEQVTAIVMATPLNENGTDLCSRYWAPSpGQKIKCMNMFVRTMATSDvkDKGYLRTLLQIEA--EDGEKRQLMHFWMYDWNPR----NPDSL
 ..|||.|...||.||| |.| |.|   | .||  . |... . |..|... ..   ..|| .. | ..   ..|| |...||....|       ....|
edFwrmlweqgvtvivmltelvelgrekcaqywPde.geeltygnftvtllseeh..ldgytvrtlevtdldgtgesrtvthfhytgwpdhgvppsfeel

LYCLRDMHLSEKQLAKGGPILVHDSAGVGRAGVIIATDFATELLESTGK---ADTLGIVRELRQDRMALVQTPEHYLLVQQAIRLF
|  .. ..   ..| ||||.||| ||||||.|..|| . . ..||..|.    | | .|..||. |.  ||.||.|  ...|.. .
ldfieevrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyeallel
DSPc_SM00195 40-272 7.4e-58 191.3 In-house 25-258 (263) alignment 
Range on Protein: 40-272
Range on HMM: 25-258/263.0
RNHKYNRYADVLPTPATRVPLAELDSDPTTAYINANFVRGAhNNKRKYIAAMAPLPATLRSWWRMIWQEQVTAIVMATPLNENGTDLCSRYWAPSPGQKI
.|.. ||| ..||   ||| | . ...... |||||...|| |.|.||||. .||| |....|||.|.|.|. ||| |  .|||   |.|||  . |.| 
knksknRyknilpydhtrVklkkeekkegsdYINAnyikga.nkkkkyIatQgPlpstvedFWrmvweekvkiivmlteeeengkekcdrywpeesggke

KCMNMFVRTMATSDVKdKGYLRTLLQIEAED-GEKRQLMHFWMYDWNPRNPD----SLLYCLRDMHLSEKQLakGGPILVHDSAGVGRAGVIIATDFATE
.  .. | .. .  .| . . .. |....|.  |.|.. .... .|. .. .    |.|  || .. |...    |||.|| ||||||.|.....|.. .
tfgkisvklvevekkk.deiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkksksts..sgpivVhCsaGvgRtgtfvtidiils

LLESTGKADTLGIVRELRQDRMALVQTPEHYLLVQQAI
 ||.. | |   ||.|||. |. .||| |.|| . .||
kleeekkvdifeivkelRkqRpgmvqtleqYlfiyeai
PTPc_SM00194 40-272 7.4e-58 191.3 In-house 25-258 (263) alignment 
Range on Protein: 40-272
Range on HMM: 25-258/263.0
RNHKYNRYADVLPTPATRVPLAELDSDPTTAYINANFVRGAhNNKRKYIAAMAPLPATLRSWWRMIWQEQVTAIVMATPLNENGTDLCSRYWAPSPGQKI
.|.. ||| ..||   ||| | . ...... |||||...|| |.|.||||. .||| |....|||.|.|.|. ||| |  .|||   |.|||  . |.| 
knksknRyknilpydhtrVklkkeekkegsdYINAnyikga.nkkkkyIatQgPlpstvedFWrmvweekvkiivmlteeeengkekcdrywpeesggke

KCMNMFVRTMATSDVKdKGYLRTLLQIEAED-GEKRQLMHFWMYDWNPRNPD----SLLYCLRDMHLSEKQLakGGPILVHDSAGVGRAGVIIATDFATE
.  .. | .. .  .| . . .. |....|.  |.|.. .... .|. .. .    |.|  || .. |...    |||.|| ||||||.|.....|.. .
tfgkisvklvevekkk.deiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkksksts..sgpivVhCsaGvgRtgtfvtidiils

LLESTGKADTLGIVRELRQDRMALVQTPEHYLLVQQAI
 ||.. | |   ||.|||. |. .||| |.|| . .||
kleeekkvdifeivkelRkqRpgmvqtleqYlfiyeai
Y_phosphatase Protein-tyrosine phosphatase 41-272 7.5e-58 191.1 Pfam-A 1-233 (235) alignment 
Range on Protein: 41-272
Range on HMM: 1-233/235.0
NHKYNRYADVLPTPATRVPLaelDSDPT-TAYINANFVRGAHnNKRKYIAAMAPLPATLRSWWRMIWQEQVTAIVMATPLNENGTDLCSRYWAPSPGQKI
|.| ||| |.||   ||| |   ..... . |||||.|.| . .|.|.||. .||. |. ..|||.|||.|..||| | |.|.|   |..||  . ... 
nkkknRykdilpydktrvkl...kgsegpsdYInAnyvkgyk.ekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeesl

KCMNMFVRTMATSDVKDKGYLRTLLQIEAEDGE--KRQLMHFWMYDWN----PRNPDSLLYCLRDMHLSEkqLAKGGPILVHDSAGVGRAGVIIATDFAT
.. ...|.... .  ..|.|  . |... ...|  ||....... .|.    |..|.||| ..|... |.   || ||..|| ||||||.|...| |.. 
tygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkveksk..eaksgpvvVhCsaGvgRtgtfvaldill

ELLESTGKADTLGIVRELRQDRMALVQTPEHYLLVQQAI
| ||.... | | ||.|||. |. .||. | |  . .||
eqleaeeevdvlqivkelRkqRpgmvqsleqYiflykai
Y_phosphatase Protein-tyrosine phosphatase 41-272 7.5e-58 191.1 In-house 1-233 (235) alignment 
Range on Protein: 41-272
Range on HMM: 1-233/235.0
NHKYNRYADVLPTPATRVPLaelDSDPT-TAYINANFVRGAHnNKRKYIAAMAPLPATLRSWWRMIWQEQVTAIVMATPLNENGTDLCSRYWAPSPGQKI
|.| ||| |.||   ||| |   ..... . |||||.|.| . .|.|.||. .||. |. ..|||.|||.|..||| | |.|.|   |..||  . ... 
nkkknRykdilpydktrvkl...kgsegpsdYInAnyvkgyk.ekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeesl

KCMNMFVRTMATSDVKDKGYLRTLLQIEAEDGE--KRQLMHFWMYDWN----PRNPDSLLYCLRDMHLSEkqLAKGGPILVHDSAGVGRAGVIIATDFAT
.. ...|.... .  ..|.|  . |... ...|  ||....... .|.    |..|.||| ..|... |.   || ||..|| ||||||.|...| |.. 
tygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkveksk..eaksgpvvVhCsaGvgRtgtfvaldill

ELLESTGKADTLGIVRELRQDRMALVQTPEHYLLVQQAI
| ||.... | | ||.|||. |. .||. | |  . .||
eqleaeeevdvlqivkelRkqRpgmvqsleqYiflykai
0043336 (Phosphotyrosine protein) phosphatases II 23-275 1.1e-57 191.0 In-house 27-276 (278) alignment 
Range on Protein: 23-275
Range on HMM: 27-276/278.0
QEIPLEAVDLTSIPAGVRNHKYNRYADVLPTPATRVPLAELDSDPTTAYINANFVRGaHNNKRKYIAAMAPLPATLRSWWRMIWQEQVTAIVMATPLNEN
.|..   .| .|| . . |.. ||| |.|| . .|| |  |..|. . ||||..| | .| .||.||. .||| |.  .|||.|...|| ||| |.| |.
eellsfkldtysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyvdg.ynvprkfiatqgPlpetvedFwrmvwelgvttivmLtelvel

GTDLCSRYWApspGQKIKCMNMFVRTMATSDvkDKGYLRTLLQIEA-EDGEKRQLMHFWMYDWNPRNPD-SLLYCLRDMHLSEKQLA-KGGPILVHDSAG
|   | .||    |. ... ...|... .    ...| .. | ..   |||.|. .|.. ..|   .   ||   |. ..   ..|. ..||.||| |||
grvkcaqYwp...ggsltygdftvtllkeeh..lddytvrtlevtnlgdgesrtvthyhylgwpdhgvpeslsllldflkavrealedsngpvlVHCsaG

VGRAGVIIATDFATELLESTGKADTLGIVRELRQDRMALVQTPEHYLLVQQAIRLF
|||.|..|| . . |.||..|. | . .|.|||. |.  ||||..|  . .|.. .
vgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflyealley
subfamily_PTPN12_pd Subfamily PTPN12 40-275 1.1e-56 186.8 In-house 39-276 (290) alignment 
Range on Protein: 40-275
Range on HMM: 39-276/290.0
RNHKYNRYADVLPTPATRVPLAELDSDPTTAYINANFVRGAHNNkRKYIAAMAPLPATLRSWWRMIWQEQVTAIVMATPLNENGTDLCSRYWAPSPGQKI
.| | ||| |.||   .|| | . ....   ||||||..|....  .|||| .|||.||  .|||||. .|. .|||  . |.|   | |||. . ....
envkknrykDilPydksrvelskieeeegsdYinanfikgvegk.leyiaaqgPLpktlddfWrmiweknveivvmaCrevelgkkkCerYWpeegeeel

KCMNMFVRTMATSDVKDKGYLRTlLQIEAEdGEKRQLMHFWMYDWN----PRNPDSLLYCLRDMHLSEKqlAKGGPILVHDSAGVGRAGVIIATDFATEL
.  .. | ...   |.|   .|| |..||. .|.|..  |   .|     |....|||  .....  ..  ..  |..|| ||||||.|.||| |.. ||
efgefevtleeekavdddflirt.Lkveaq.kesrkvyqfhYtaWPDhgvPssaksllelielvrelqe..sedaPlvvhCsaGvGrtGtiiaidyvrel

LESTGK---ADTLGIVRELRQDRMALVQTPEHYLLVQQAIRLF
|..       |   .|.|||..| ||||| | | || .|.  .
lkaekipeeldvfdlvlelrkqraalvqtkeqyelvykavael
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 22-278 1.4e-56 186.6 In-house 11-270 (274) alignment 
Range on Protein: 22-278
Range on HMM: 11-270/274.0
FQEIPLEAvDLTSIPAgVRNHKYNRYADVLPTPATRVPLAEL-DSDPTTAYINANFVRGAHNNKRKYIAAMAPLPATLRSWWRMIWQEQVTAIVMATPLN
| |.||.  |   .    .... ||| ..|| . .|| | .   .|. . |||||...| ..... |.|.  ||| |.  .||||.||.|. ||| | |.
flelPlnf.dqeeldv.fgsqtknryktilPnensrvllesessededssyinanyikGydeeskayvatqGPlpntvadfWrmiyqeevqvivmltklk

ENGTDLCSRYWAPSPGQKIKCMNMFVRTMATSDVKDKGYLRTLLQIEAEDGeKRQLMHFWMYDW----NPRNPDSLLYCLRDMHLSEKQLAKG-GPILVH
|.  . |..|.  . . .|.     |    .. |. ..|  . | ..     .|...|.|  ||     |.....||  ..... |... ..  .|..||
eaneqkCavyfPdaedyeiserygdveikvekiverndysvrklvlkyler.ersvkhywytdWPdhksPddantlldlvleveesreeenaklapvvvh

DSAGVGRAGVIIATDFATELLESTGKADTLGIVRELRQDRMALVQTPEHYLLVQQAIRLFART
 |||.||.|. ||.. |   |. ... | |.|| .||.||  .||| | | |. .|. |... 
CsaGiGrtGcfiaisiavrqlreeivvdvlkivcnlrldrGGmvqtseqyelihralclylkr
0040439 (Phosphotyrosine protein) phosphatases II 37-274 3.5e-56 185.9 In-house 7-244 (249) alignment 
Range on Protein: 37-274
Range on HMM: 7-244/249.0
AGVRNHKYNRYADVLPTPATRVPLAELDSDPTTAYINANFVRGAHNNKRkYIAAMAPLPATLRSWWRMIWQEQVTAIVMATPLNENGTDLCSRYWAPspG
  . |...||| |.|| . .|| |  |.. . . ||||... | . ..| .||. .||| |. ..|||.|....|.|||.|.| |.|   | .|| .  |
llpenkdknrypdilpydhsrvklsilpglflsdyinAsyidgyyikrr.fiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywpl..g

QKIKCMNMFVRTMATSDvkDKGYLRTLLQIEA-EDGEKRQLMHFWMYDWNPRN----PDSLLYCLRDMHLSEKQLAKGGPILVHDSAGVGRAGVIIATDF
. ... ...|... .     ..| .. |...  .|||.|. .|....||   .    ...||  .. ..   ..| ||||.||| ||||||.|..|| . 
gsleygdftvtllsvev..kddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaayl

ATELLESTGKADTLGIVRELRQDRMALVQTPEHYLLVQQAIRL
. |.|| ... | . .|..||. |.  ||.||.|  ...|.. 
mleqlekelgvdleeavkllrsqRpgavqnpeqyrflyealle
0042113 (Phosphotyrosine protein) phosphatases II 37-274 5.4e-55 181.8 In-house 5-241 (245) alignment 
Range on Protein: 37-274
Range on HMM: 5-241/245.0
AGVRNHKYNRYADVLPTPATRVPLAELDSDPTTAYINANFVRGaHNNKRKYIAAMAPLPATLRSWWRMIWQEQVTAIVMATPLNENGTDLCSRYWAPspG
. . |...||| |.|| . ||| | . ..|. . ||||..| | .. ..|.||. .||| |.  .|||.|....|.||| |.. |.|   | .|| .  |
llpenkdknrysdilpydhtrvklspdggdldsdyinasyvdg.yritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywpl..g

QKIKCMNMFVRTMATSDvkDKGYLRTLLQIEA-EDGEKRQLMHFWMYDWNPRNPDS-LLYCLRDMHLSEKQLA--KGGPILVHDSAGVGRAGVIIATDFA
..... ...|... .    ...| .. |...   |.|.|. .|.. ..|   .. . | . |. ... .|.||  ..||.||| ||||||.|..|| . .
esltygdftvtllseeh..lddytvrtlevtnlgddesrevihyhylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylm

TELLESTGKADTLGIVRELRQDRMALVQTPEHYLLVQQAIRL
 |.||.... .   .|.|||. |.  ||||..|  ...|.. 
leqlekelgvsleeavkelrsqRpgavqtpsqyrflyealle
subfamily_PTPRB_pd Subfamily PTPRB 39-277 3.4e-54 178.8 In-house 49-286 (293) alignment 
Range on Protein: 39-277
Range on HMM: 49-286/293.0
VRNHKYNRYADVLPTPATRVPLAELDSDPTTAYINANFVRGAhNNKRKYIAAMAPLPATLRSWWRMIWQEQVTAIVMATPLNENGTDLCSRYWaPSPGQK
 .|.. ||| ..||  ..|| ||.|...... |||||...|  | .|..||.  ||| |.   |||.|......||| | | |.|   | .|| |.  . 
avnraknrytnilpydhsrvkLaalkdesgsDYinanyipgy.nsprefiatqGPlpetvddfWrmvwekkssiivmltqlvekgkvkCeeYW.Padeep

IKCMNMFVRTMATSDVKDkgYLRTLLQIEAeDGEKRQLMHFWMYDWN----PRNPDSLLYCLRDMHLSEKQLAKGGPILVHDSAGVGRAGVIIATDFATE
.   .. |  .|.....|  .    |.||  . |.|.....    |     | ....||  .| .. . .. |. .||.|| ||||||.|. || |  ..
vlyGdikvtlvaeeeled..wvirelkiek.ekeerkvrqyhftsWpdhgvPektktlldfvrtvreaiektaskrPivvhCsaGvGRtGtfialdrllq

LLESTGKADTLGIVRELRQDRMALVQTPEHYLLVQQAIRLFAR
 .|..   | .||| |||..|. |||| ..|. ..|..  . |
aieeedyvdifgivaelReeRnllvqtekqYifihqcvldllr
subfamily_PTPRD_pd Subfamily PTPRD 40-273 4.7e-54 179.0 In-house 47-278 (564) alignment 
Range on Protein: 40-273
Range on HMM: 47-278/564.0
RNHKYNRYADVLPTPATRVPLAELDSDPTTAYINANFVRGaHNNKRKYIAAMAPLPATLRSWWRMIWQEQVTAIVMATPLNENGTDLCSRYWaPSPGqKI
 | . ||||....  ..|| | ... |. . ||||.|. | ......|||. .||. |.. .|||.|..... ||| | |.|.|.. |..|| |. | . 
aNkaKNRyanivaYdhsRVvLskvegdegsDYINAsfidg.yrkrkayIAtqgPlaetiedFWRmvweqnsstiVmltkleEkgkvkchkYW.Pekg.te

KCMNMFVRTMATSDVkDKGYLRTLLQIEAEDGEKRQLMHFWMYDW----NPRNPDSLLYCLRDMHLSEkQlAKGGPILVHDSAGVGRAGVIIATDFATEL
.. .. |  ... ..  .  .||.   .... |.|.  .|   .|     | .. |||  .|... .. .  . |||.|| |||||| |. |. |   | 
tygeltVtleeeeel.adyeirtfklkkkkssesreVrqFhFtsWPdhgvpesatslLdlirkvraln.e.pdagPivVhCSaGVGRTGtfividamler

LESTGKADTLGIVRELRQDRMALVQTPEHYLLVQQAIR
... .. |  ..|..||..| |.|||.| |  . .|| 
ikeektvDiyqyvkalrkqRnamVqteeQYiFiheail
0045098 (Phosphotyrosine protein) phosphatases II 38-275 3.5e-52 172.9 In-house 30-271 (278) alignment 
Range on Protein: 38-275
Range on HMM: 30-271/278.0
GVRNHKYNRYADVLPTPATRVPlaeldsdpttAYINANFVRGAhnnKRKYIAAMAPLPATLRSWWRMIWQEQVTAIVMATPLNENGTDLCSRYWAPspGQ
 . | . ||| |.|| . .||            ||||....|    ..|.||. .||| |. ..|||.|....|.|||.|.| |.|   | .|| .  |.
ylgnldknRykdilpydhsrVk..........dYINAsyidgy...pkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrekcaqywpe..gg

KIKCMNMFVRTMATSDVkDKGYLRTLLQIEA----EDGEKRQLMHFWMYDWNPRNPDSLL---YCLRDMHLSEKQLA--------------KGGPILVHD
 . . ...|... .. . |. .||||| .      ||.|.| . |.... |   .. ||    . |. .   .. |.              .|||.||| 
sltygdftvtllseevl.ddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsggpvlVHC

SAGVGRAGVIIATDFATELLesTGKADTLGIVRELRQDRMA-LVQTPEHYLLVQQAIRLF
||||||.|...| .   |||   |. | | .|.|||. |.   ||..|.|  . ......
saGvgRtGtlvaaylmlell..eggvdlleavkelrsqRpglavqnleqyrflyefllel
subfamily_PTPN9_pd Subfamily PTPN9 41-277 1.7e-49 163.5 In-house 42-291 (297) alignment 
Range on Protein: 41-277
Range on HMM: 42-291/297.0
NHKYNRYADVLPTPATRVPLAELDSDPTTAYINANFVRGAHnNKRKYIAAMAPLPATLRSWWRMIWQEQVTAIVMATPLNENGTDLCSRYWAPSPGQKIK
| . |||.|||    ||| ||..| |... ||||||| | . .|. .||.  ||. | . .|||.|...|  |||.| . |.|   |..|| .. .. ..
nleknrytdvlcydetrvvlakvdedeasdyinanfvdGyk.qkkafiatqGplkktvsdfWrmvWeqevlvivmttrvvergrlkcgqyWpleeessae

CMNMFVRTMATSdvKDKGYLRTLLQIE-AEDGEKRQLMHFWMYDWN----PRNPDSLLYCLRD-----------MHLSEKQLAKGGPILVHDSAGVGRAG
  .. |... .   . . |  . |.|. ....|.|...|| .  |     |..  |||  |.            .  ..|  ..| ||.|| |||.||.|
fgdlsvsnveve..eeedykvrvleiknvkteesrkvthfqflsWPdyGvPssaaslldvlekvrekqalavkelgdewkghpsgPPivvhcsaGiGrtG

VIIATDFATELLESTGKADTLGIVRELRQDRMALVQTPEHYLLVQQAIRLFAR
  |. |.. . ||..|..|    |. ||. |   .|||| | .  .|.  .| 
tfitldiclsrleevgtvdvvetvkllrtqrafsiqtpeqyefcylavleyal
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 40-273 2.3e-49 163.2 In-house 45-277 (318) alignment 
Range on Protein: 40-273
Range on HMM: 45-277/318.0
RNHKYNRYADVLPTPATRVPLAELDSDPTTAYINANFVRGAHnNKRKYIAAMAPLPATLRSWWRMIWQEQVTAIVMATPLNENGTDLCSRYWapsPGQKI
 |.. ||||..|.   ||| | .|...... |||||.. | . .|..|||| |||| |.. .|||.|. . . ||| | ..|.| . . |||   |... 
vnkaknryanilaydhtrvkLqmlegeegsDyinanyidGyr.rkkayiaaqaPlpetieDfWrmvWeqnsavivmltqeeergkakvhryW...Pskgs

-KCMNMFVRTMATSDVkDKGYLRTLLQIEAEDGEKRQLMHFWMYDWN----PRNPDSLLYCLRDMHLSEKQlAKGGPILVHDSAGVGRAGVIIATDFATE
 .  .. |  . . .. ..  ||..   . |  |.||   . . .|     | .. |||  .|. .  ... .. |||.|| ||||||.|| || |   |
rsygklvvelkeevel.sdyvlrefkvtrteeeesrqvrqyhytsWpdegvpesgaslldlvrqvskaqqk.sgagpivvhCsaGvGrtGvfiavdille

LLESTGKADTLGIVRELRQDRMALVQTPEHYLLVQQAIR
 ..  .  | ...|..||. | ..||| . | .. ... 
rikaealvDvfqtvkqlreqrnlmvqtedqyefiydvll
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 31-278 2.6e-49 163.0 In-house 36-285 (305) alignment 
Range on Protein: 31-278
Range on HMM: 36-285/305.0
DLTSIPAGVRNHKYNRYADVLPTPATRVPLAELDSDPTTAYINANFVRGaHNNKRKYIAAMAPLPATLRSWWRMIWQEQVTAIVMATPLNENGTDLCSRY
. . .     |.. ||.... . .  |. |.| .|.. . ||||..| | ...| |||.| .||. |.. .||.|..|.|. ||| | | |.| | | .|
esidvgkkeankaknrlkeitlldddriiltekeslddsdyinasyvdg.ykrkkkyivaqgPlkntvadfWrliveekvstivmltklveggkdkCrqY

WAPSPGQKIKCmNMFVRTMaTSDVKDKGYLRTLLQIEA--EDGEKRQLMHFWMYDW----NPRNPDSLLYCLRDMHlSEKQLAKGGPILVHDSAGVGRAG
|. | ..| .  . |. .. .|  . ..|.   |.|    || |.|..... . ||     |. . |||  .....  ...  || |.||| ||||||.|
Wpesktekkef.gefsvel.ksektasdyieRklkisiededkesrtvlqyqltdWPdhGvpqfatsllslikrvq.kdqkkdkgvpllVhCsagvgRtG

VIIATDFATELLESTGKADTLGIVRELRQDRMALVQTPEHYLLVQQAIRLFART
| || | | | |.  .  |  .....||. || .||| ..|  . .|. .   .
vfiavdialerlkkEevvdvfevlkqlRskrmkmvqtldqYvflhdaldelitc
subfamily_PTPN13_pd Subfamily PTPN13 29-272 1.6e-47 157.1 In-house 25-265 (273) alignment 
Range on Protein: 29-272
Range on HMM: 25-265/273.0
AVDLTSIPAGVRNHKYNRYADVLPTPATRVPLAELDSdpttaYINANFVRGA-HNNKRKYIAAMAPLPATLRSWWRMIWQEQVTAIVMATPLNENGTDLC
..| ...    .|.. ||| .|||  .|||.| .  .     ||||....    ... .|||.  ||| | .  |.|.|. ... |.| |   |.|   |
pldtcevgkkkenkdknryrnvlPydetrvklgdegg.....yinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweqkaeviamvtlekekgkvkc

SRYWAPSPGQKIKCMNMFVRTMATSDVKDKGYLRTLLQIEAEDGEKRQLMHFWMYDWN----PRNPDSLLYCLRDMHLSEKqlaKGGPILVHDSAGVGRA
 |||  | ..|.|  | .  ..     .|   .|.|  .. | || |...|. . .|     |.....||  .. .   ..   . |||.|| |||.||.
hrywPesknkklkvsnrlevellkvqkldgfvvralavkdsesgesrevahlnfvkwPdhgvPssaaellqfvaevrrlqt...dagPivvhcsaGiGrs

GVIIATDFATELLESTGKADTLGIVRELRQDRMALVQTPEHYLLVQQAI
|..|. | . .|.|   . |   |||.||. | ..||| . |..| .||
Gtlitidvvlglierdkefdvkeivrklreqrqgvvqtkdqyifvykai
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 40-272 1.8e-47 156.8 In-house 40-272 (281) alignment 
Range on Protein: 40-272
Range on HMM: 40-272/281.0
RNHKYNRYADVLPTPATRVPLAELDSDPTTAYINANFVRGAHnNKRKYIAAMAPLPATLRSWWRMIWQEQVTAIVMATPLNENGTDLCSRYWApSPGQKI
 | . ||| ..    |||| ... ... .| ||||||| | . ....|||. .|.||.| ..|.|.|...|.|||| |   |.|   | |||   . ...
envlknrYsnivaYDatrvkvtpneenkntDYinanfvpgyk.gekeyiatqgPvPaslvafWqmvweqkvsaivmvtreieagklkChrYWP.ddnsel

KCMNMFVRTMATSdvKDKGYLRTLLQIEAEDGEKRQLMHFWMYDWN----PRNPDSLLYCLRDMHLSeKQLAKGGPILVHDSAGVGRAGVIIATDFATEL
|  .. |...|..  . . |..  ...|.|.||.|.. ..    |     | ..  ||   ....   ..  .  |...| ||||||.|. || | . . 
kygdvtvkstaee..ekatyierkfkleresgetreveqlaytaWPdhGvPattkellefrkevlkl.tekktkaplvihCsaGvGrtGtyialDrlvka

L-ESTGKADTLGIVRELRQDRMALVQTPEHYLLVQQAI
. ... ..|   .|.|||..|. .|||   |  | .|.
veaeleeldvkavvaelrkernlmvqtvvqyefvykav
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 39-280 4.7e-47 155.6 In-house 46-287 (319) alignment 
Range on Protein: 39-280
Range on HMM: 46-287/319.0
VRNHKYNRYADVLPTPATRVPLAELDSDPTTAYINANFVRGaHNNKRKYIAAMAPLPATLRSWWRMIWQEQVTAIVMATPLNENGTDLCSRYWAPSpgQK
 .|.| ||| ..|.   ||| |.|||  . . ||||.|. | .....|.||..|||  |.  .|||.|.|..  .|| | |.|..   ...||     . 
eenkkknryqnilaydrtrvvlseldgvegsdyinasfidg.yqerekfiatqaPlentiedfWrmvWeeessivvmltklveklkvklkkywpee..nf

IKCMNMFVRTMatSDVKDKGYLRTLLQIEAEDGEK--RQLMHFWMYDWN----PRNPDSLLYCLRDMHLSEKQlAKGGPILVHDSAGVGRAGVIIATDFA
 .  .. |     .. . ..|    |...   .|   |...||   .|     |..  |||  |.... | ..  . ||| || |||||| |  |. | .
eeyGrlivtle..eeeeledyiirklklnkkssevetRevkhfqyteWpdhdvPekatslldllkrirksrek.tqsgPivvhCsaGvGRtGtfivldam

TELLESTGKADTLGIVRELRQDRMALVQTPEHYLLVQQAIRLFARTAG
 | ..  |  |   .|..||  |  .||.|| | .. .|.. .. .  
lervkeegvlDvfstvsrlRtqRnimvqrpeqYkfiyealleaveagd
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 39-273 5.5e-47 155.0 In-house 41-273 (515) alignment 
Range on Protein: 39-273
Range on HMM: 41-273/515.0
VRNHKYNRYADVLPTPATRVPLAELDSDPTTAYINANFVRGAHNNKrKYIAAMAPLPATLRSWWRMIWQEQVTAIVMATPLNENGTDLCSRYWAPSPGQK
  |.| ||| ..||   .|| |  .. .|   |.|| .... .|.|  |||. .|..|..  .||...||.||.|.| | |.|.    |..||   ||. 
einfkknryknilPydsvrvklevindnPhsdyfnasyipsfdndk.ayiasqgPnkasvddfWrlvlqenvttiamvtklkegdkikcgkyWPdkpgds

IKCMNMFVRTMATSDVKDkGYLRTLLQIEAEDgeKRQLMHFWMYDW----NPRNPDSLLYCLRDMHLSEKQLAkgGPILVHDSAGVGRAGVIIATDFATE
.|  .. | .....   . |  |.|  .  .|   | .  | . .|     |..  |||  ....  .. |..   |...| ||||||.||.|. |    
vkfGsikvelvsleactg.gikrkltvlkgdd..srtvtqfhfteWPdkGvpkhtssllklikevkadhgqyt..hpliihcsaGvGrtGvvisidsvva

LLESTGKADTLGIVRELRQDRMALVQTPEHYLLVQQAIR
  . |   | . .|. .||.|. |||| |.| .. .|..
hakttrmvdvfnfvtnirqkrpylvqtqeqyafiygavl
0037934 (Phosphotyrosine protein) phosphatases II 36-274 8.7e-47 155.1 In-house 5-240 (243) alignment 
Range on Protein: 36-274
Range on HMM: 5-240/243.0
PAGVRNHKYNRYADVLPTPATRVPLaeldsDPtTAYINANFVRGAhnNkrKYIAAMAPLPATLRS----WWRMIWQEQVTAIVMATPLNENGTDLCSRYW
.  . |.. ||| |.|| . .|| |     .. . |||||....   .  ..||  .||| |. .    .|||.|....|.||| |.| |.|   | .||
allpenlsknrysdilpydhsrvkl.....eg.sdyinanliyvt..p..rliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqyw

ApspGQKiKCMNMFVRTMATSDVKDkgYLRTLLQIEA--EDGEKRQLMHFWMYDWNP----RNPDSLLYCLRDMHLSEKQ------LAKGGPILVHDSAG
    |..  . ...|... ..  .|  |  . |..|   .|...|. .|.. . |       .|..||  |....   ..      | .|||.||| |||
p...gev.tygdftvtllseehldd..ytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaG

VGRAGVIIATDFATELLestgKADTLGIVRELRQDRMA-LVQTPEHYLLVQQAIRL
|||.|..|| .   .||    . | . .|..||. |.   ||||..|  ...|.. 
vgRtGtliaaylmllll....gvdleeavkllreqRpgkavqtpsqyrflyealle
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 27-276 9.1e-47 154.5 In-house 33-279 (288) alignment 
Range on Protein: 27-276
Range on HMM: 33-279/288.0
LEAVDLTSIPAGVRNHKYNRYADVLPTPATRVPLAELDSDPTTAYINANFVRGAHNnKRKYIAAMAPLPATLRSWWRMIWQEQVTAIVMATPLNENGTDL
||  . ...    .|.| ||| ..||   .|| | .|.  ... ||||... | .. |.||||. .||..|.  .|......... ||| | | |.|   
lektksvtagrlavnakknRyrnilpyDekrvklkkleeeagaDYinasyidgekk.kkkyiatqgPladtvndfWelvyenktstivmltelveggktk

CSRYWaPSPGQKIKCMNMFVRTMATSDVKDkGYLRTLLQIeaEDGEKRQLMHFWMYDW----NPRNPDSLLYCLRDMHLSEKQLakGGPILVHDSAGVGR
| .|| |. ... .  .. |  . . ...|   ||.||     ....... ..    |     |..   ||  || .. ....    |||.|| ||||||
CeeYW.PdadkpknyGsvtvtlveskeled.fvlrkllle..kkkteleitqyqylaWpdhgvPeskapllellrqvkvanqad..tgpiivhCsaGvGr

AGVIIATDFATELLESTGKADTLGIVRELRQDRMALVQTPEHYLLVQQAIRLFA
.|. || | . . .|.. . | .|.| .||. |. |||| ..|  . ...   .
tgtFialdalidaveeedyiDvagtvaklRkqRallvqtlkqYefiyevllsli
subfamily_PTPN6_pd Subfamily PTPN6 39-278 1.6e-46 153.7 In-house 52-299 (306) alignment 
Range on Protein: 39-278
Range on HMM: 52-299/306.0
VRNHKYNRYADVLPTPATRVPLAeLDSDPTTAYINANFVRGAHNN-KRKYIAAMAPLPATLRSWWRMIWQEQVTAIVMATPLNENGTDLCSRYWaPSPGQ
..|.. |||  .||   ||| |.  .| | . |||||..... .. ...|||.   |..|.  .|||.|||. . |||.|  .| | . |.||| |.  .
penkeknryknilPfDhtrvilk.epsvpgsdyinanyikkevkgsdksyiatqgclettvsdFWrmvwqensrvivmttkevErgkekCarYW.Pdeee

KIKCMNMFVRTMATSDVkDKGYLRTLLQI-EAEDGEKRQLMHFWMYDW----NPRNPDSLLYCLRDMHLSEKQLA--KGGPILVHDSAGVGRAGVIIATD
| .  .. |.... ..  ..  ||.|.   . ...|.|.....   .|     |..|. .|  |.|..  ...|.  . |||.|| |||.|| | .| .|
keeyGkisvtnvseksl.adYilRelsvskkkkkkeerevfqyhfksWPdhgvpkdpgavLdfledvnrkqeeleeaeagpivvhCsaGiGRtGtfiviD

FATELLESTG---KADTLGIVRELRQDRMALVQTPEHYLLVQQAIRLFART
  ..|.|..|   . |   .|. .|. |  |||| . | .| .||. . .|
illkliekkgldadidiqklvksvreqrsglvqteqqykfvykaikkyiet
subfamily_PTPN3_pd Subfamily PTPN3 40-272 1.1e-45 150.8 In-house 40-271 (280) alignment 
Range on Protein: 40-272
Range on HMM: 40-271/280.0
RNHKYNRYADVLPTPATRVPLAELDSDpttaYINANFVRGA---HNNKRKYIAAMAPLPATLRSWWRMIWQEQVTAIVMATPLNENGTDLCSRYWaPSPG
.| . ||| |.||  |||| | | ..|    |||||.|      ..   .|||.  ||. |   .|.|.|..... ||| | | |.|   | .|| |...
enlsknryrdilpydatrvklkesetd....yinanyvnmeipstglvnryiatqGPlaktatdfWqmvweqksslivmlttlverGrvkChqyW.Pete

QKIKCMNMFVRTMATsDVKDKGYLRTLLQIEAEDGEKRQLMHFWMYDWN----PRNPDSLLYCLRdmHLSEKQLAKGGPILVHDSAGVGRAGVIIATDFA
....  .. |.   . | . .  || |.  ..|  |.|.....   .|     | .....|  ..  .. ... .|  |..|| |||.||.||.|. . |
deleygefsvkceke.detksyvlrelvlkdketkeerkilqlqylaWpdhgvPddsadflefve..rvrklrsgkeePvvvhCsaGigrtGvlilleta

TELLESTGKADTLGIVRELRQDRMALVQTPEHYLLVQQAI
  |.|.. .   | |||..|. |..||||.. | .| .||
lalieaaepvypldivrtmrdqramlvqtasqykfvCeai
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 40-273 3.8e-45 149.3 In-house 49-281 (297) alignment 
Range on Protein: 40-273
Range on HMM: 49-281/297.0
R-NHKYNRYADVLPTPATRVPLAELDSDPTTAYINANFVRGAHNnkrKYIAAMAPLPATLRSWWRMIWQEQVTAIVMATPLNENGTdLCSRYWAPSPGQK
. | . .||...||.   || || ...||   |.|| ||.| ..   ..|.   | .||.  .|.|...|||..||| . .||.    | |||. .  ..
kvnfeksRYkniLPydssRvkLaivnddpdsDyvnasfvkgnkh...rlittqmPmkatvadfWamvldeqvstivmlnddnerdk.kcaryWsdkgvtt

ikCMNMFVRTMATSdvKDKGYLRTLLQIEAEDGEKRQLM-HFWMYDWNP----R--NPDSLLYCLRDMHLSEKQLAKGgPILVHDSAGVGRAGVIIATDF
    .. | ....|  . .|...  |... ..  .|...  .   .|      |  .  |||  . ... . .| |.| |.||| .|||||.||... | 
..fGdvsvvllsvs..ereGfikrelevtkgkakarrvvkqyqfveWPdkaverkdsassllklisevrkdfsqnaeg.PllvhclaGvGrtgvlltids

ATELLESTGKADTLGIVRELRQDRMALVQTPEHYLLVQQAIR
     . . . | .|.|. |||.|. |||| |.| .| .|. 
vvaeakrekevdifglvkklrqerpylvqtkeqykfvyvavl
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 37-275 6.3e-45 148.4 In-house 40-276 (315) alignment 
Range on Protein: 37-275
Range on HMM: 40-276/315.0
AGVRNHKYNRYADVLPTPATRVPLAELDSDPTTAYINANFVRGAHNNKrKYIAAMAPLPATLRSWWRMIWQEQVTAIVMATPLNENGTDLCSRYWAPSPG
    |.| ||| ..||   .|| |  .| .|   |||| .... ...|  |||. .||.|..  .|||..||.||.||| | ..|.    | .||    .
retinfkknryknilPldsarvkleviddsPdsdyinasyiksvdddk.ayiasqgPlkasvddfwrmvlqekvttivmvtkkqegdkikcrqywPdrka

QKIKCMNMFVRTMATSDVKDkGYLRTLLQIEAEDGEKRQLMHF--WMYDWNPRNPDSLLYCLRDMHLSEKQlaKGGPILVHDSAGVGRAGVIIATDFATE
. ..  .. | .. ..   | |  | |   ..|. ..    .|  |     ...  |||  ....  ....  |  ..||| ||||||.||.|. |   .
dsvefGsikvellsleadtd.gvarklvtrkseesrtvtqfqftewPdkGvdkqtssllklikevkadngk..kefsllvhcsaGvGrtGvvisidevva

LLESTGKADTLGIVRELRQDRMALVQTPEHYLLVQQAIRLF
 .. |   | . .|..||..|. |||| |.| .. .|..  
qikrtrsvdvfnfvknlrakrpylvqteeeyafiydavled
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 39-273 1.9e-44 147.1 In-house 54-287 (298) alignment 
Range on Protein: 39-273
Range on HMM: 54-287/298.0
VRNHKYNRYADVLPTPATRVPLAELDSDPTTAYINANFVRGAHNNKrKYIAAMAPLPATLRSWWRMIWQEQVTAIVMATPLNENGTDLCSRYWapsPGQK
 .|.| |||||...   .|| | . |.|  . |||| |. ......  .||. |||..|.  .|||...|....||| |.|.| ..  ...||   | ..
penkkkNRyadiialdssRvvLekedadeesdYiNAsflhaykgrn.afiatqaPltetvedFWrmvteedigtiVmltnleeldktkyhkyw...Pdeg

I-KCMNMFVRTMAtSDVKDKGYLRTLLQIEAEDGEKRQLMHFWMYDW----NPRNPDSLLYCLRDMHLsEKQLAKGGPILVHDSAGVGRAGVIIATDFAT
  .  .. |. .. .... .   |.|   ...  ..|.. .. .  |     |.|  |.|  ||...   .| |.  |..|. ||||||.|  || |   
ketygeitvslls.keefadlivrklkvskkkeekerevrqlhftsWpdkgvpenatsvldllrkvra.sqqqagnkpvivqCsaGvgRsGtfiaidsvl

ELLESTGKADTLGIVRELRQDRMALVQTPEHYLLVQQAIR
| ..   . | . .|. ||..|...||| |.|  . .|. 
ervkkeqvvDvfqvvkvlRkkrpgavqteeqYvfiyeavl
subfamily_PTPRG_pd Subfamily PTPRG 39-275 4.4e-44 145.6 In-house 45-286 (563) alignment 
Range on Protein: 39-275
Range on HMM: 45-286/563.0
VRNHKYNRYADVLPTPATRVPLAELDSDPTT-AYINANFVRGaHNNKRKYIAAMAPLPATLRSWWRMIWQEQVTAIVMATPLNENGTDLCSRYWaPSpGQ
  |.. ||| ....   .|| |..|     .  |||||.. | .. ....||.  ||. |.  .|||||...|. ||| | |.|.|   | .|| |.  .
penkrKnRylnivaydrsRvklsplpgkkkklDYinAnyidG.yqkskafiatqgplkdtfddFWrmiWeqnvaiivmitnlvergrrkcdvYW.Pk.de

KIKCMNMFVRTMATsDVKDKGYLRTLL----QIEAED--GEKRQLMHFWMYDW-NPRNPDSLLYCLRDMHLSEKQLA-KGGPILVHDSAGVGRAGVIIAT
 ... .. |. ... .|.     |||     ......   .... ... . .| ..  |.. |. |  .. |..    . |||.||.||||||.|. |. 
setygalqvtliee.evlalytvrtlviknlklkkkkqcdteklvrqyhytkWPdhgvPehslpvLifvkkssaankaeaGPivvHcsaGvgrtGtyivl

DFATELLESTGKADTLGIVRELRQDRMALVQTPEHYLLVQQAIRLF
|  .. ...  . . .|... .|  |  |||| | |. . .|.   
dtllkqiqqenavnvfgflkhiraqRnflvqteEqYiflhdallea
subfamily_PTPRK_pd Subfamily PTPRK 40-273 1.8e-43 143.6 In-house 42-274 (314) alignment 
Range on Protein: 40-273
Range on HMM: 42-274/314.0
RNHKYNRYADVLPTPATRVPLAELDSDPTTAYINANFVRGaHNNKRKYIAAMAPLPATLRSWWRMIWQEQVTAIVMATPLNENGTDLCSRYWaPSPGQKI
 |.. ||. |.|.   .|| |  .| || . ||||... . ... ...|..  ||. |.. .||....|. ..||| | | |.|   |..|| |  ... 
enreknrsgdilaydrsrvflitidgdpssdyinaalids.ykrpaafivtqgPlqetvkdfWrlvydencasivmltelvevgrvkClkyW.Pedtevy

KCMN-MFVRTMATSDVKDKGYlrTLLQIEAEDGEKRQLMHFWMYDWN----PRNPDSLLYCLRDMHLSEKQlaKGGPILVHDSAGVGRAGVIIATDFATE
. .. ..|.| . ...  . .  .. ...    |.|.. .|    |     | .  .||  .| .. |...  . |.|.|| ||| ||.|. || |   .
gdikvelvetellaelvvrif..rveklargqeeirevrqfqflgWpdhdvPvsatgllklvrrvkksqee..eaGrivvhCsaGaGrtGtfiaidivld

LLESTGKADTLGIVRELRQDRMALVQTPEHYLLVQQAIR
..|  |  |   .|..||. .. .|.| | | .. ..| 
mieregvvdvfnavktlrsrkvnmveteeqykfiydvil
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 39-274 4e-43 142.4 In-house 45-276 (287) alignment 
Range on Protein: 39-274
Range on HMM: 45-276/287.0
VRNHKYNRYADVLPTPATRVPLAeldsDPTTAYINANFVRGaHNNKRKYIAAMAPLPATLRSWWRMIWQEQVTAIVMATPLNENGTDLCSRYWAPSPGqk
 .|.. ||....|.    ||.|     .    |||| |. | ...|...|.| .|.  |.| .|..|....|||||| . ..|| .. | .||. .    
sqnkdknRltqilvpdnyrvllk....gehpdyinavfidg.ykekkafiiaesPmfntarnfWkliddrnvtaivmlcqekendeevcyqyWpeeks..

iKCMNMFVRTMATSDvKDKGYLRTLLQIEA--EDGEKRQLMHFWMYDWNPRN----PDSLLYCLRDMHLSEKQLAKgGPILVHDSAGVGRAGVIIATDFA
  ..  .  ..   . . .||.   |...   ..|.|.|.. . . .|. .     | . |  . .|  .... .. ..|.|| |..|||... .| . .
.vvlGeyniellnee.vnagyierklevknknkagdkqqvkqyqitnWdstgkvtepqtillvieemyktqrkrgn.tsivvhCsdtvGrsamfcaaatt

TELLESTGKADTLGIVRELRQDRMALVQTPEHYLLVQQAIRL
 .  .  |  | . .... |. ..  ||| |.|  .....  
inkckteGviDvfqvlksqriqkpgsvqtveqykfindivle
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 38-272 3.2e-42 139.4 In-house 43-279 (290) alignment 
Range on Protein: 38-272
Range on HMM: 43-279/290.0
GVRNHKYNRYADVLPTPATRVPLAEL--DSDPTTAYINANFVRGaHNNKRKYIAAMAPLPATLRSWWRMIWQEQVTAIVMATPLNENGTDLCSRYWAPSP
.  |.. ||.|.....   |..| ..  . | |  |||| .. | ...|..|||. .|.. ||. .|..||||.||.||| |  .|.|.. |  ||. |.
tssnkllnRfanivvyddnritLrpisghkDCtneyinAcyikg.ykekkqyiatqgpvsntlvdFWkliwqekvtiivmltniieegkvkCqqYWpdsd

GQKikcMNMFVRTMATSDVKDkGYLRTLLQIEAEDG--EKRQLMHFWMYDWNPRN----PDSLLYCLRDMHLSEKQLAkGGPILVHDSAGVGRAGVIIAT
 ..   .. |  ..    . . .| .. |... ..   .|...... .  |..      | . |  .. |   ...    ..|.|| |..|||..| .|.
tka...ygefsikllneetln.eyierklevknknsagakqsvtqyqitnwdstgkvtnpqtillvieemyktqrkrg.ntsivvHCSdtvgrsavfcaa

DFATELLESTGKADTLGIVRELRQDRMALVQTPEHYLLVQQAI
. . .  ...|  | . .....|. .. .||| ..| .. | .
attinkcktegvidvfqvlksqRiqkpgsvqtvqqyqgifqiv
subfamily_PTPRA_pd Subfamily PTPRA 36-275 7.5e-42 138.4 In-house 53-294 (330) alignment 
Range on Protein: 36-275
Range on HMM: 53-294/330.0
PAGVRNHKYNRYADVLPTPATRVPLAELDSDPTTAYINANFVRGaHNNKRKYIAAMAPLPATLRSWWRMIWQEQVTAIVMATPLNENGTDLCSRYWaPSP
 .   |.. ||. ..||   .|| |....  ... |||| |. | ...| |.|||  |.  |.  .|||||. . ..||| | |.|   . | .|| |. 
askeenkeknrvvnilPydfsrvilsvkeGveesdyinasfidG.ykekdkfiaaqGPkeetvedfwrmiweqksativmltelkerkeekcaqyw.Pde

GQkIKCMNMFVRTMATSDVKDKGyLRTLL-Q---IEAEDGEKRQLMHFWMYDWN----PRNPDSLLYCLRDMHLSEKQLAKggPILVHDSAGVGRAGVII
|  .   |. |    .  ..|   .| .| |    .... ..|..  | .  |     | .|  .|  |. ..  ..| |   || || ||||||.|  |
Gl.vtyGnirvevedetvlvdyt.vrkflvqqlpdatrekksrlvrqfhftswPdvGvPfepiGmlkllkkvkklnqqsag..pivvhcsaGvGrtGtfi

ATDFATELLESTGKADTLGIVRELRQDRMALVQTPEHYLLVQQAIRLF
. |   | ... .| |  ..|..||. |  .||| | | .. .... .
vldavlervkaerkvdvfefvkrlrlqrpqmvqtdeqyefiykvlley
subfamily_Ptp69D_pd Subfamily Ptp69D 40-277 1.3e-41 137.7 In-house 47-287 (307) alignment 
Range on Protein: 40-277
Range on HMM: 47-287/307.0
RNHKYNRYADVLPTPATRVPLAELDSDPTTAYINANFVRGaHNNKRKYIAAMAPLPATLRSWWRMIWQEQVTAIVMATPLNENGTDLCSRYWAPSpgQKI
 |   ||| |. .   ||| |...  . .. ||||.|..| ...|.|.||| .|. ||.  .||||.. .|| ||| . |.|   . |..||.    ...
enalknRyedikafDktRvkLkkingkedsdYinasfikg.ykekkkfiaaqdPveatigDfWRmiaeqevtlivmlsnlteknrkkcakYWpie..dev

KCMNMFVRTMATSDVKDkgYLRTLLQIEAED------GEKRQLMHFWMYDWN----PRNPDSLLYCLRDMHLSEKQLakGGPILVHDSAGVGRAGVIIAT
.  .. |... ..  .|  | .  |..   .       ..|... .    |.    |. . .||  .. ..  .|.    .||.|| ||||||.|...| 
qygdilvklvseekhsd..yiiReldvskkkeesgevedsrkvvqyhytgWkDskvPevargllklieqvrelykln..rsPivvhCsaGvgrsgifval

DFATELLESTGKADTLGIVRELRQDRMALVQTPEHYLLVQQAIRLFAR
|   . |.   |.|   .|..||..|  |||  | |  . .|.  .  
dsllqqlkaedkvdifetvkdLrsqRnllvqsleqYvflyralldyss
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 33-272 2.5e-40 133.1 In-house 25-262 (283) alignment 
Range on Protein: 33-272
Range on HMM: 25-262/283.0
TSIPAGVRNHKYNRYADVLPTPATRVPLAELDSdpttAYINANFVR--GAHNNKRKYIAAMAPLPATLRSWWRMIWQEQVTAIVMATPLNENGTDLCSRY
. | .  .|...||. ...|.   || |  .       |||| |.     .....|||.| .||  | . .|.|...|..||||| |.| |.    ||.|
adiasadenkrknrnqeivpadqwrvelksesr....dyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfdekitaivmltklqedlrikCsqy

WaPSPGQKikCMNMFVRTMAtSDVKDKGYLRTLLQIEAEDGEKRQL--MHFWMYDWNPRNPDSLLYCL--RDMHLSEKQLAKGGPILVHDSAGVGRAGVI
| |. | .      |  |.   ..  . . . .| .  .   | .|   |. . ||   .... .  |   .   | ..  | |||.|| |.|.||..| 
W.PkrGse..dyGeftvtlr.kettsnsfiikelllrvnssakstlllahyqvidWleygeqaiinslvkfnkvislqteskkgPivvhCstgiGrtavf

IATDFATELLESTGKADTLGIVRELRQDRMALVQTPEHYLLVQQAI
||   . . . .    |   .|. .|..|| .||| . | || ...
iaasasvkdaltesvvdvfavvkimreqrmmavqtldqyklvhelv
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 40-278 3e-40 132.8 In-house 37-279 (287) alignment 
Range on Protein: 40-278
Range on HMM: 37-279/287.0
RNHKYNRYADVLPTPATRVPLAElDSDPTTAYINANFVRGaHNNKRKYIAAMAPLPATLRSWWRMIWQEQVTAIVMATPLNENGTDLCSRYWaPSPGQKI
 . | ||||||||   ||| |.. ...  ..|||||.| . .... ..||| .|..||.|..||............ |   |..   | .|| | . . .
aavkknryadvlPiddtrvllsa.egelGsdyinanyvas.ytddeafiaaqgPiaatvrdfwravletrsasvitmtreveearlkcykyw.PerevPm

KCMnMFVRTMATSDVKDKGY-LRTLLQIEAEDGEKRQLMHFWMYDWnPRN---PD--SLLYCLRDM--HLSE-KQLAKGGPILVHDSAGVGRAGVIIATD
.    .  ..   |.|.  |  |.|  |..|  | | .  . ...| | .   |   .|.    |.  |.   .. .. ||..|||..|.||.|...|| 
rvG.GysvvlldydikePeygvralrlidletrearvvkqldllsw.PdkvlaPtavglirfvldvkqhielardasevGPlvvhddvGiGrsGillatl

FATELLESTGKADTLGIVRELRQDRMALVQTPEHYLLVQQAIRLFART
   . ||..|. |.  .|  ||. | ||||..  . |. .|.  . .|
vlvsrledlGrvdvaavvirlreyraalvqavvqlrllyealvtyykt
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 39-274 3.2e-40 132.9 In-house 7-240 (250) alignment 
Range on Protein: 39-274
Range on HMM: 7-240/250.0
VRNHKYNRYADVLPTPATRVPLAELDSDPTTAYINANFVRGAHNNkRKYIAAMAPLPATLRSWWRMIWQEQVTAIVMATPLNENGTDlCSRYWapsP-GQ
 .|.. |||||...   .|| | . ..|  . |||| |. | ... . .||. .||.||.  .|||...|....||| | |.|..   ...||   |  .
pqnkeknryadiialdssrvvLekekgdkesdyinasflhgyder.kafiatqgPlqatiedfWrmvleeksgtivmLtnLkesekt.yhqyw...Pvek

KIKCMNMFVRTMATSDVKDkGYLRTLLQIEAEDGEKRQLMHFWMYDW----NPRNPDSLLYCLRDMHLSEKQlAKGGPILVHDSAGVGRAGVIIATDFAT
  |  .. |  . .    |    |.|   .|.  ..|.. ..    |     |..  . |  |.... |..| |. .|..|. ||||||.|  || |   
aekyGdvtvsllskeefad.ytkrklklskakkaderivrqlhfvvWPdkgvPevatavLellkkvqasqqq.agnaPvivqCsaGvgrsGafiaidavl

ELLESTGKADTLGIVRELRQDRMALVQTPEHYLLVQQAIRL
| |.   . |   ... ||.||.  |.. | |  | ..|  
erlkkekvvdvfkvikvlrkdrphavesleqyvfvyeiilk
subfamily_PTPN14_pd Subfamily PTPN14 36-272 4.7e-38 125.9 In-house 44-292 (300) alignment 
Range on Protein: 36-272
Range on HMM: 44-292/300.0
PAGVRNHKYNRYADVLPTPATRVPLAELDSDpTTAYINANFVRGA-HNNKRKYIAAMAPLPATLRSWWRMIWQEQVTAIVMATPLNENGTDLCSRYWaPS
 .   | . ||. ||||   .|| |.    . .| ||||  .. .   ..|.||.| .||. |.. .|.|.|...|. ||| |  .|.| . . .|. |.
aklpenaeknrfkdvlPyednrvelsptken.stgyinassikvsvggkersyivaqgPleltvqdfWqmvWeqgvqlivmlteeeedgkeksfkyf.Pk

PGQKIKCMNM-FVRTMATSDVKDKGYLRTLLQIE-AEDGEKRQLMHFWMYDWN----PRNPDSLLYCLRDMHLS-----EKQ--LAKGGPILVHDSAGVG
 ..| | ..    . ..    . . .  | |...    .|.|...|.   ||     |..... |  |....       ...    .  |.||| |||||
leskkktvefgkfkvttkfsedsdsvittglklkhlpskeertvwhlqytDWpdhgvPeDvkgflsyLeevqsvrrktnseveskeskPPvlvhCsaGvG

RAGVIIATDFATELLESTGKADTLGIVRELRQDRMALVQTPEHYLLVQQAI
|.||.| .|. .. ||   . |   ... ||. || ||||   |  | ...
rtGvlilsdlliatlehneeidikkvlarLreqrmllvqtlaqYkfvYkvl
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 40-272 5.9e-38 125.9 In-house 60-287 (319) alignment 
Range on Protein: 40-272
Range on HMM: 60-287/319.0
RNHKYNRYADVLPTPATRVPLAELDSDPTTAYINANFVRGaHNNKRKYIAAMAPLPATLRSWWRMIWQEQVTAIVMATplnengTDLCSRYWAPSPGQKI
.|   ||. ..|.   ..| |  |.    . |||| || | . .| |||||  ||. ||  .|||||. ....||. |       | ||.||     .| 
qnkdknriinilafdknvvklerliGeefsdyinasfvtG.yqrkdkyiaaqGPldntladfWrmiweyncstivllt......kdkcsqywplkivike

KCMNMFVRTMATSDVkdkgYLRTLLQIE--AEDGEKRQLMHFWMYDWN----PRNPDSLLYCLRD-MHLSEKQLAKgGPILVHDSAGVGRAGVIIATDFA
. ... | ..  ..     |    ...   ..  ..|..  | .  |     |  |  |.  ..   || .|.  .  .|.|| ||||||.|| |. |  
erfkvkvdsveetae....yvvrdielsedgkekdirkitqfhflGwpdvGvpdypsdlmrlvkkvrhltskenhr.anivvhcsaGvGrtGvyivldvl

TELLESTGKADTLGIVRELRQDRMALVQTPEHYLLVQQAI
 . ..   . |   .||.|||.|  |||    | ..  |.
ldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysal
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 40-272 7.5e-38 125.6 In-house 24-251 (284) alignment 
Range on Protein: 40-272
Range on HMM: 24-251/284.0
RNHKYNRYADVLPTPATRVPLAELDSDPTTAYINANFVRGaHNNKRKYIAAMAPLPATLRSWWRMIWQEQVTAIVMATplnengTDLCSRYWAPSPGQKI
.|   ||. ..|.   ..| |  |.    . |||| |. | . .| ||||.  ||. ||  .|||||. ....||. |       | ||.||     .| 
qnkdknrighilafdknvvklerliGeefsdyinasfitG.yqrkdkyiatqGPldntladfWrmiweyncstivllt......kdkcsqywplkivike

KCMNMFVRTMATSDVkdkgYLRTLLQIE--AEDGEKRQLMHFWMYDWN----PRNPDSLLYCLRD-MHLSEKQLaKGGPILVHDSAGVGRAGVIIATDFA
. ... | ..  |.     |    ...   ..  ..|..  | .  |     |  |  |.  ..   ||..|.  .  .|.|| ||||||.|| |. |  
erfkvkvdsveesee....yvvrdielsedgkekdirkirqfhflgwpdvgvpdypsdlmrlvkkvrhltsken.hranivvhcsagvgrtgvyivldvl

TELLESTGKADTLGIVRELRQDRMALVQTPEHYLLVQQAI
 . ..   . |   .||.|||.|  |||    | ..  |.
ldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysal
subfamily_PTPN1_pd Subfamily PTPN1 20-272 1.1e-37 124.4 In-house 10-267 (290) alignment 
Range on Protein: 20-272
Range on HMM: 10-267/290.0
TLFQEIPLEAVDLTSIPAGV-RNHKYNRYADVLPTPATRVPLAELDSdpttAYINANFVRgAHNNKRKYIAAMAPLPATLRSWWRMIWQEQVTAIVMATP
.....|  || |..   |   .|.. ||| || |   .|. | . |      ||||..|  ... ||.|| .  ||| |   .|.|.|...  |.||   
eiyldirkeasdfptreaklpenrnlnryrdvspydhsrikleradn....dyinaslve.leeakrsyiltqGPlpntvdhfWqmvWeqkskavvmlnk

LNENGTDLCSRYWAPSPG-QKIKCMNMFVRTMATSDVKDKGYLRTLLQIEA-EDGEKRQLMHFWMYDWN----PRNPDSLLYCLRDMHLSEKQLAKGGPI
. |...  | .||      ..... .. ..    |  . . | . ||..|  .  | |...||    |.    |. | ..|  | ..  |     . || 
vvekeqikcaqywPqgeeekellledtklkvkliseerksyytvrllelenlktqetreilhfhyttwpdfgvpespaaflkflfkvresGslssdvGpa

LVHDSAGVGRAGVIIATDFATELLESTGKADTLGIV---RELRQDRMALVQTPEHYLLVQQAI
..| |||.||.| ..  |    |.| ....... |     |||. |. |.||..   .  .||
vihcsaGiGrsGtfclvdtclvliekkddlssvdikkvllelrkyrlGliqtadqlrfsylai
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 40-273 1.8e-37 124.2 In-house 47-285 (325) alignment 
Range on Protein: 40-273
Range on HMM: 47-285/325.0
RNHKYNRYADVLPTPATRVPLAELDSDPTTAYINANFVRGAhNNKRKYIAAMAPLPATLRSWWRMI--WQeqvTAIVMATPLNENGTDLCSRYWAPSPGQ
 | . ||. .|..   .|| |  .. || . ||||...|    .|  ..|| |||.||.   ||..  |.   ...|. .   ..| | |. ||    |.
enkaknrfknvvaldksrvvletkkddpssdyinasylrdd.kkkdvflaaqaPltatindlWrlvldWr...csvvvvlneldlgkdrcavywpkemgk

KIKCMNMFVRTMATSDVKDkgYLRTLLQI-EAEDGEKRQLMHFWMYDWN----PRNPDSLLYCLRDM-HLSEKQLA---KGGPILVHDSAGVGRAGVIIA
  .   . |. ..  .. |  |.   |.. ....|| | .  | .  |.    .. | .|.  |. . ..||.  |     .||||| ||||||.|| |.
sktfGglevklrtieeisd..yvhrvldvkqvkkGetrsvkqfqlqswddmGvqkrpatlisilqlvkavservtantkastpilvhcsaGvGrtGvfis

TDFATELLESTGKADTLGIVRELRQDRMALVQTPEHYLLVQQAIR
   | . .    . | .| |. ||.|| ..|.| . | |. .|. 
lysalakvieesrvdifgfvkklrkdrpsmvetvdqyiliyealv
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 38-272 1.2e-36 121.3 In-house 46-275 (315) alignment 
Range on Protein: 38-272
Range on HMM: 46-275/315.0
GVRNHKYNRYADVLPTPATRVPLAELDSDPTTAYINANFVRGaHNNKRKYIAAMAPLPATLRSWWRMIWQEQVTAIVMATPLNENGTDLCSRYWapsPGQ
 . |.. ||| .....  .|| |  |. || . |.||||. | .| ||.|||| .|..|... .||....|... ||| | | |.    . .||   | .
kienkqknryiniiaydksrvqlpllendphsdyvnanfidG.ynkkrryiaaqgpnvasvkdfwrlvfeedigkivmltnlvegekrkaekyw...pdk

KIKCMNmFVRTMATSDVKDKGYLRTLLQIEAEdgEKRQLMHFWMYDWNPRNPDSLLYCLRDMHLSEKQ--LAKGGPILVHDSAGVGRAGVIIATDFATEL
|.   . .  |.   .|...   |||  .  .  . |... . .  |   .       | ...   ||   .. |.|.|| ||||||.|  |. |   . 
kviyGk.itvtrkseevnteytvrtlsvvfgd..nirevvqlhytswpdmgvpkytiplmnlirtvkqhhtnsvgaivvhcsaGvGrtGtfitldavldq

LESTGKADTLGIVRELRQDRMALVQTPEHYLLVQQAI
.|     |   ... .|| |. .||. | | .. .|.
aeaenaidvynfitgvrqnrikmvqvaeqyqfiydal
0041856 (Phosphotyrosine protein) phosphatases II 41-275 2.9e-36 120.1 In-house 1-170 (182) alignment 
Range on Protein: 41-275
Range on HMM: 1-170/182.0
NHKYNRYADVLPTPATRvplaeldsdpTTAYINANFVRGAHNNKRkYIAAMAPLPATLRSWWRMIWQEQVTAIVMATplnengtdlCSRYWApspgqkik
|...||| |.|| . .|             |||||...|.. ..| .||. .||. |. ...||......|.||..|         . .||.        
nldknrysdilpydhsr..........dldyInanlylgslpatr.fiatqgpllstvadflrmlkelgittivnlt.........eelywp........

cmnmfvrtmatsdvkdkgylrtllqieaeDGEKRQLMHFWMYDWNPRNPDSLLYCLRDMHLSEKqlaKGGPILVHDSAGVGRAGVIIATDFATELlestg
                             . ..|. .... . |   .. .|  .|. ..  ..   .|||.||| ||||||.|...| ..  .|     
.............................ellerlgiqylylpwpDhgvpdldelldfieevle...eggpvlVHCsaGvgRtgtlvaaylmkkl.....

KADTLGIVRELRQDRMALVQTPEHYLLVQQAIRLF
. .   .|...|. |.  |.||..| ..|.|....
gvsleeavklvrsrRpgmvitpnqyfflqlallel
subfamily_PTPN23_pd Subfamily PTPN23 33-277 3.1e-36 119.7 In-house 35-281 (288) alignment 
Range on Protein: 33-277
Range on HMM: 35-281/288.0
TSIPAGVRNHKYNRYADVLPTPATRVPLAeldsDPTTAYINANFVRGAHNNKRKYIAAMAPLPATLRSWWRMIWQEQVTAIVMATPLNENGTDLCSRYWA
.|| .  .. . ||. |.||   .|| |     . .  |||| ||..      ..||. |||. ||  .|.|......  ||| .  .| |   ..||| 
rsiaiaklyseknrsrdilPyDhnRvklr....gskDDYinAsfvkdlspgcPdfiatqaPlqstlnDFWlmvyeqkssviVmllskeelgkpkvdrYwP

PSPGQKIKCMNMFVRTMatSDVKDKGYLRTLLQIEAEDG-EKRQLMHFWMYDWN----PRNPDSLLYCLRDMHL--SEKQLAKGGPILVHDSAGVGRAGV
 . |.  |  .. |     |  . . . .  |..| .|  ......|  .  |     |  |..||  |  ..   ...|     |..|| ||||||.||
edkgetvkfgdlsvtlk..svretethvervlkletldadavksvshlqltsWpelGvPasPetllqfldevesayeavqrksktPlvvhCsaGvgRtgv

II-ATDFATELLESTGKADTLGIVRELRQDRMALVQTPEHYLLVQQAIRLFAR
.      ..|| .  | .|.. .|. ||..|   ||. |..  . .|.   ||
falvyaavrelekgnglldiiqvvsrlreqRrfmvqekeqlkfsyeavleaar
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 34-275 1.5e-34 114.1 In-house 33-292 (301) alignment 
Range on Protein: 34-275
Range on HMM: 33-292/301.0
SIPAGVRNHKYNRYADVLPTPATRVPLAELDS--DPTTAYINANFVRGAHnNKRKYIAAMAPLPATLRSWWRMIWQEQVTAIVMATPLNENGTDLCSRYW
..    .|...||. .. . .  |. |..  .    .. ||||... |   .|.|.||| .|.  ||. .||.||||....||| | |.|.  . | .||
tvglseenkalnrfknitvyddnriilkpkpnldlcqreyinasyidgys.ekkkfiaaqgpmkktlvdfWrliwqekpvsivmvtnlkegtkskceqyw

APSPGQKIKCMNMFVRTMA---------------TSDVKDKGYLRTLLQIEAEDgEKRQLMHFWMYDWNP----RNPDSLLYCLRDMhLSEKQLAKGGPI
  |  .. . ... |  .                  |. ..||.   ......  . .... . . ||      |.|   |  . |. .  .|   |||.
pnseaeseefgpftvtlvneqvyPdfvirqlnvkiqdgsnngyierkfkvksdk.sswdvlqlqvtdWpqdGvvreprtvLqviddv.ihrqqkigggpv

LVHDSAGVGRAGVIIATDFATELLESTGKADTLGIVRELRQDRMALVQTPEHYLLVQQAIRLF
.|| |..|.|.|| .. . . |   . |  |  .... .|. ..  |.| | |  . ..|  .
vVHCSdtVsrsGvYcsvsiglEQckaegVVdvfqvtkavrrskpgaVtTLeqytsiydvidmy
0051429 (Phosphotyrosine protein) phosphatases II 68-277 1.7e-33 111.9 In-house 3-226 (272) alignment 
Range on Protein: 68-277
Range on HMM: 3-226/272.0
TTAYINANFVRGAhNN---KRKYIAAMAPLPATLRSWWRMiWQEQVTAIVMATPLNENGTDLCSRYWA----------PSPGQKIKCMNMFVRTMATSDV
.. ||||..| |  ..   ....... .|||.| ...||. .......||. ....| | . |.|||.          ..  . |  ....|... ..  
lsgyiNardvggy.grvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseell

KDKGYLRTLLQIEAEDGEKRQLMHFWMYDWNPRNP--DSLLYCLRDMHLsekqlakGGPILVHDSAGVGRAGVIIATDFATELLESTGKAD--------T
 |  . . || ..   || |..||....||  ..   ..||  |. ..        |||.||| |||..| |...| .   . .. .  .|         
ldyilrellltlllsagearevmhlhytdwpdhgvpqeallellellld.......ggpvlvHCsaGkdRTGtvvallllllgvsletivddYlltnlyl

LGIVRELRQDRMALVQTPEHYLLVQQAIRLFAR
...|.|||. |.. |||.|.|| ...|.. ..|
eeaveelraqrpgavqteeqylflyeallellr
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 34-273 2.3e-33 110.3 In-house 41-276 (439) alignment 
Range on Protein: 34-273
Range on HMM: 41-276/439.0
SIPAGVRNHKYNRYADVLPTPATRVPLAELDSDPTTAYINANFVRGAHNNKrKYIAAMAPLPATLRSWWRMIWQEQVTAIVMATPLNENGTdlcsrYWaP
|. |   ..  ||| || .   ||| | |.   | . |||||...| ...|  |||. .|   |  ..||........ ||| | | |        || |
slaaqeydqtknrykdvgafdhtrvtlqeipgvphshyinanyikGyyddk.lyiatqgpkkettddfwrlviekktvtivmltnlvesyk.....yw.p

SPGQKIkCMNMFVRTMATSDVKDKgYLRTLLQIEAED-GE-KRQLMHFWMYDWNPRNPDSLLYCLRDM---HLSEKQLAKGGPILVHDSAGVGRAGVIIA
| .. .   .. ||.    .. .   .| .  ..  | .| .| ...|    |  .|  .    . |.     | ..  . ||..|| ||||||.| |||
sdaevc.ygdiavrvdrnielpny.virgfkvfnerdttekertvlqfhyiawpdknvpaqashvldflrainsandkeeygpvvvhcsagvGrtGtiia

TDFATELLESTGKADTLGIVRELRQDRMALVQTPEHYLLVQQAIR
 | | | | .  | |  |||. ||..|  .||.  .|.....|. 
ldialeqlklenkvdikgivkvlrkqrkqmvqalcqyvfiynavl
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 41-272 4.3e-33 109.2 In-house 56-279 (290) alignment 
Range on Protein: 41-272
Range on HMM: 56-279/290.0
NHKYNRYADVLPTPATRVPLAelDSDPtTAYINANFVRGAhnnKRKYIAAMAPLPATLRSWWRMIWQEQVTAIVMATPLNENGTDLCSRYWAPSPGQKIK
. | ||| ||     ||| |   |  .   |. ||.|.|    |  .| .  .| .|    |||. ||.|.||||   | |.|   |..|.    |. . 
efkknrykdvvcndktrvilk..dGyd.GdyvhanyvkGl...kamfiltqGalkdtvidiwrmvlqekvaaivmlceliedGkakceqyypekeGevlt

CMNMFVRTMATSDVKDKGYLRTLLQIEAEDGEKRQLMHFWMYDWNPRN-PDSLLYCLRDMHLSEKqlaKGGPILVHDSAGVGRAGVIIATDFATELLEST
  .. |     .|  ..  ..||   . ..| . .| |. .  |  .  . | |  || ..   |     ||. || |||.||.| ..| . . ..|   
fGeitvlcseeddkdaniikktlsvrdkdsGkehklkhlkikswpdksvalstlallrtlrilrk...asGpvvvhcsaGiGrtGtfvaievglqilldG

GKADTLGIVRELRQDRMALVQTPEHYLLVQQAI
 . | |..|| ||. |.. ||    ||.. ...
keldlldlvralrnsrlnsvqvdiqylalveil
subfamily_CG42327_pd Subfamily CG42327 34-185 6.1e-33 108.8 In-house 23-172 (319) alignment 
Range on Protein: 34-185
Range on HMM: 23-172/319.0
SIPAGVRNHkyNRYADVLPTPATRVPLAELDSDPTTAYINANFVRGAHNNKRKYIAAMAPLPATLRSWWRMIWQEQVTAIVMATPLNENGTDLCSRYWAP
 .|.. ...  .|...|.| | ||| | .  .|. . |..|..||| .. .  |||| ..|  .  ..||..|. |   || .| | |.| . |..|. .
evPvtskdk..srvinvvPlPetrvvlqrigdddkdeyldasyvrGyddapnsyiaaqvsledsssdfwrtvweqqsrvivqltdlselGikvcaeylPt

SPGQK-IKCMNMFVRTMATSDVKDKGYLRTLLQIEAEDGEKRQLMHFWMyDWN
. . .  .    .  |.   .|||. .. |||  . .. | |.| |.|  .| 
ketldntslyGdilvtlkgrevkdryaistlllkrvdkeesrelthywy.kwl
subfamily_CG7180_pd Subfamily CG7180 40-268 1.7e-32 107.3 In-house 41-282 (296) alignment 
Range on Protein: 40-268
Range on HMM: 41-282/296.0
RNHKYNRYADVLPTPATRVPLAELDSDPTTAYINANFVRGaHNNKRKYIAAMAPLPATLRSWWRMIWQEQVTAIVMATPLNENGTdLCSRYWAPSPgqKI
 | . ||. .|.|   .|| | .|| . .. |||| .| . .  |..||   ||   |. ..||....|.. |.|. |   .    ..  || .    | 
enreknrdvkvvPyDynRvvLekldGeeksdYinavyvds.flkkkeyivteapkketvdefWrlvydeeisavvvLtktfdfak.mypsywpnks..ke

KCMNMFVRTMATSDVKD---KGY--LR----TLLQIEAEDGEKRQLMHFWMYDWNP--RNPDS---LLYCLRDMHLSEKQL---AKGGPILVHDSAGVGR
.  ..|| .. .    .   . .   .    .  | . .. |.| ...| .  |.   . | |   |.. .| ..|  ..     . ||..|. | |..|
qygeifveiveekqyanlkirtfkltkkivalteqekqvkaetRivklfqlteWeledkvPlstnalielrrrvrlwrekvdedpeegPvvvvssdGasR

AGVIIATDFATELLESTGKADTLGIVRELRQDRMALVQTPEHYLLV
.|| .| | . ||.| ... |  . |. ||..|  ||.. |.|  .
sGvylaidanlelvekeeevdvFeavktlrrsRpqLvenveeYkyi
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 30-272 2.7e-32 106.6 In-house 34-232 (392) alignment 
Range on Protein: 30-272
Range on HMM: 34-232/392.0
VDLTSIPAGVRNHKYNRYADVLPTPATRVPLAELDSDPTTAYINANFVRGAHNNKrKYIAAMAPLPATLRSWWRMIWQEQVTAIVMATPLNENGtdlcsr
.  ...     | | ||| ..||  ..|| |  .|  | . |.|| .... .|.|  |||. .| .|.|  .|||..||.||.|.| | |.|        
iypqtvaqkeinlkknryknilpydsarvkleviddipdsdylnasyipsfdnek.ayiasqgpnaaslddfwrmvfqenvttiamvtklkegd......

ywapspgqkikcmnmfvrtmatsdvkdkgylrtllqieaEDGEKRQLMHFWMYDWN----PRNPDSLLYCLRDMHLSEKQLAKggPILVHDSAGVGRAGV
                                          ..|    | . .|     |.   |||  .....    | ..  |...| ||||||.||
.......................................kgddartvaqfhftewPdkdvpkhtssllkfikevkadfGqyth..pliihcsagvgrtgv

IIATDFATELLESTGKADTLGIVRELRQDRMALVQTPEHYLLVQQAI
.|. |      . |   | . .| ..|. |  .||| |.| ..  |.
visidsvvahakktrmvdvfnfvtnirrkrpymvqtkeqyafiygav
subfamily_PTPRN_pd Subfamily PTPRN 40-272 2e-31 103.8 In-house 55-288 (297) alignment 
Range on Protein: 40-272
Range on HMM: 55-288/297.0
RNHKYNRYADVLPTPATRVPLAELDSDPTTAYINANFVRGAHNNKRKYIAAMAPLPATLRSWWRMIWQEQVTAIVMATPLNENGTDLCSRYWaPSPGQKI
.| | ||...|||   .|| | |  |. .. |||| ..      .  |||. .||..|. ..|.|.|.. |. ||. |.|.|.|.  |.||| |  |...
knvkknrskavlpydhsrvklkeeasaeksdyinasaildhdprapayiatqgplastvadfwqmvweqGvvvivnltrleeegvkqckryw.pdeGsev

KcmNMFVRTMATSDVKDKGYL-RTLLQIEAEDGEKRQLMHFWMYDWN----PRNPDSLLYCLRDMHLSEKQlaKGGPILVHDSAGVGRAGVIIATDFATE
   ...   . .  .  . || |..   . .  | | .  |    |.    | .. |||   | .  | .   .  ||.|| |.|.||.|| |. |.  .
y..hiyevhlvsehiwcddylvrsfylknlqtsetrtvtqfhflswpeegvPasaksllefrrkvnksyrG..rscpivvhcsdGaGrtGvyilidlvln

-LLESTGKADTLGIVRELRQDRMALVQTPEHYLLVQQAI
 ||    . |    .  ||..|  ||.| . . .. .|.
rllkGvkeidiaatlehlrdqrpglvktkdqfefaltav
0046846 (Phosphotyrosine protein) phosphatases II 62-275 3.9e-30 100.3 In-house 5-172 (176) alignment 
Range on Protein: 62-275
Range on HMM: 5-172/176.0
ELDSDPTTAYINANFVRGAhnnkrKYIAAMAPLPATLRSWWRMIWQEQVTAIVMATPLNENGTDLCSRYWAPSPGQKIkcmnmfvrtmatsdvkdkgylr
.|  |.   |||||.. |.     ..||  .||| || ....|......||.|. | . | |   | .||    . .|                      
llgldldldyinanlilgs.....rpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgi......................

tllqieaedgekrqlmHFWMYDWNPRNPDSLLYCLRDMHLSEKQLAKGGPILVHDSAGVGRAGVIIATDfateLLESTGKADTLGIVRELRQDRM-ALVQ
                ... ..|   .. .| ..|. . . ...| .|||.||| |||.||.|...| .    |||.    . . .....|. |.   ||
................qylhlpwpDhgvpdlelllellefirealkeggpvlVHCsaGigRtgtlvaay....llelekglsveealalvreqRplgavq

TPEHYLLVQQAIRLF
|||.|  ......|.
tpeQyrflyefelll
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 40-290 9.5e-30 98.4 In-house 47-301 (305) alignment 
Range on Protein: 40-290
Range on HMM: 47-301/305.0
RNHKYNRYADVLPTPATRVPLaelDSDPTTAYINANFVRGAHNNKRkYIAAMAPLPATLRSWWRMIWQEQVTAIVMATPLNENGTDLCSRYWAPSPGQKI
.... ||| ||      || |   ..     || ||.|    | || .| . |||  |   .| | .|..| || |   | | |.  |. |.|   ....
qeagknrykdvgcldnnrvkl...egpwpheyihanyvstptnpkr.fictqaplektcadfwymclqdkveaifmlcnllekgakkcleyfaskdkdvl

K----CMNMFVRTMATS-----DVKDKGYLRTLLQIEAEDGEKRQLMHFWMYDWNPRNPDSLLYCLrdMHLSEKQLAKGGPILVHDSAGVGRAGVIIATD
.       . |.  ...     .  .    .| | ||   ...|.  |.   ||  |   .   ..  . | ||  .  ||| || |||.||.| ..  .
efeekgqkisvkfessvtlkfrkdakakvtetvlviegpgekarkvthyhwidwpdrgvpaadlai..lellekarpskgpivvhcsagigrtgsvvmle

FATE-LLESTGKADTLGIVRELRQDRMALVQTPEHYLLVQQAIRLFARTAGVALSEIEDIH
.  . ||.     ||  |.. .|..|   .|| . ||.| | |  . |  ..   |.....
yildqllagqiiedtdkilqkireqrnnsiqtdaqylfvhqvilnyfrkkklldeevkeay
0036282 (Phosphotyrosine protein) phosphatases II 70-270 1.5e-29 98.3 In-house 3-164 (174) alignment 
Range on Protein: 70-270
Range on HMM: 3-164/174.0
AYINANFVRGAHNNKrKYIAAMAPLPatlrsWWRMIWQEQVTAIVMATPLNENGTDLCSRYWAPspgqkikcmnmfvrtmatsdvkdkgylrtllqieAE
 ||||... . . .. ..||  .||.      |.|......|..|| ....|.|  .| .||                                      
dyinaspldlsyitp.rliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe..................................lr

DGEKRQLMHFWMYDWNPRNPDSLLYCLRDMHLSEKQLAK--GGPILVHDSAGVGRAGVIIATDFATELLEsTGKADTLGIVRELRQDRMALVQTPEHYLL
. ..|  .... . |  ... .|   |. . . |. |..  |||.||| ||||||.|...| .    .|. ..  | | .|||||. |.  ||||..|  
edlerlgiqylylpwpDhgvpdlsillefvkfveealsedpggpvlVHCsaGvgRtGtlvaaylmlrgll.eslvdaldlvrelRlqrpgmvqtpsQyrf

VQQ
...
lyy
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 41-272 3e-29 96.9 In-house 8-237 (239) alignment 
Range on Protein: 41-272
Range on HMM: 8-237/239.0
NHKYNRYADVLPTPATRVPLAELDSDPTTAYINANFVRGAHNNKRKYIAAMAPLPATLRSWWRMIWQEQVTAIVMATPLNENGTDLCSRYWAPSpgqKIK
|.  ||||...    .|| | .|  || . ||||...|    . . |||.   . ..   .|||.|||.   ||| | | |     | .||  |     |
nkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpds...tsk

CMNMFVrTMATSDVKDKGYLRTLLQIEAEDGEKRQLMHFWMYDWNPRNPD---SLLYCLRDmHLSEKQLAKGGPILVHDSAGVGRAGVIIATDFATELLE
  |. | |.  ..|     .||..  .  . |.| . .. .  |  .      . .  ||  ....  |    | ..| ||||||.| ..  |      .
ycnlrv.tlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrr.kitkdslpgarpwvihcsagvgrtgaflvidamlrqak

STGKADTLGIVRELRQDRMALVQTPEHYLLVQQAI
     | .  |. .|.||  .||| |.|.... |.
kqktvdifnyvkairedrphmvqtseqyvfihlav
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 41-272 3e-29 96.9 In-house 7-236 (239) alignment 
Range on Protein: 41-272
Range on HMM: 7-236/239.0
NHKYNRYADVLPTPATRVPLAELDSDPTTAYINANFVRGAHNNKRKYIAAMAPLPATLRSWWRMIWQEQVTAIVMATPLNENGTDLCSRYWAPSpgqKIK
|.  ||||...    .|| | .|  || . ||||...|    . . |||.   . ..   .|||.|||.   ||| | | |     | .||  |     |
nkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpds...tsk

CMNMFVrTMATSDVKDKGYLRTLLQIEAEDGEKRQLMHFWMYDWNPRNPD---SLLYCLRDmHLSEKQLAKGGPILVHDSAGVGRAGVIIATDFATELLE
  |. | |.  ..|     .||..  .  . |.| . .. .  |  .      . .  ||  ....  |    | ..| ||||||.| ..  |      .
ycnlrv.tlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrr.kitkdslpgarpwvihcsagvgrtgaflvidamlrqak

STGKADTLGIVRELRQDRMALVQTPEHYLLVQQAI
     | .  |. .|.||  .||| |.|.... |.
kqktvdifnyvkairedrphmvqtseqyvfihlav
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 38-274 1.9e-28 94.3 In-house 30-257 (267) alignment 
Range on Protein: 38-274
Range on HMM: 30-257/267.0
GVRNHKYNRYADVLPTPATRVPLAELDSDpttaYINANFVRGaHNNKRKYIAAMAPLPATLRSWWRMIWQEQVTAIVMATPlneNGTDLCSRYWAPSPGQ
.  |.. ||. |.||   |||.| . . .    |||| .| | .. |...|.   ||  |   .. .| ...|. ||. |.    .||   ..| |  ||
aeknqernrlddnlpyddtrvilrtkeee....yinasyveg.yktknafivtqdplkntitdfltvihdqkvpvivlltk...vftdnirlfwPPkmgq

KIKCMNMFVRTMATSDVKDKGYLRTLLQIEAEDGEKRQLMHFWMYDWNPRNpDSLLYCLRDMhLSEKQLAKGG-PILVHDSAGVGRAGVIIATDFATELL
  |  .. |      . .|   .   |... |   .  | ..  .. |  |    |  |  . |...|| .|. |..|. |.||||.|  .  |   | .
akkyqdltvehslekeendyqiitlelkfknesahnvtlyyykkwnintnn.kpylkplfgi.laknqlengnrPlvvacsdGvGrsGtflvidsqlera

ESTGKADTLGIVRELRQDRMALVQTPEHYLLVQQAIRL
   | .|    .|..|. |..||.| |.|. . . .  
ktegvsdifdflrkirsqriglvdtkeryiyihellae
0043147 (Phosphotyrosine protein) phosphatases II 67-270 3.2e-28 94.0 In-house 3-155 (172) alignment 
Range on Protein: 67-270
Range on HMM: 3-155/172.0
PTTAYINANFVRGAHnNKRKYIAAMAPLPATLRSWWRMIWQEQVTAIVMATPLnengtdlcsrywapspgqkikcmnmfvrtmatsdvkdkgylrtLLQI
. . ||||... . .   ...||  .||. || . |||......|.||..|.|                                           |.  
egsdyinasyldlyy.ipdrfiatqgplrntladfwrmlkelgithivnltel...........................................lydp

EAEDGEKRQLMHFWMYDWNPRNPDSLLYCLRDMHLSEkQLAKGGPILVHDSAGVGRAGVIIATDFATellestGKADTLGIVRELRQDRMALVQTPEHYL
| .  .  |.... ..| .. ... || .|. ..    .| .|||.||| ||||||.|...| .          . . . .|...|. |.  ||.|..| 
ellerlgiqylylpwpDhgvpllellleflefidell.alspggpvlVHCsaGvgRtgtlvaaylml......lglsleeavalvrekRpgavqnpsqyr

LVQQ
....
flyy
0049260 (Phosphotyrosine protein) phosphatases II 83-270 3.5e-28 93.6 In-house 7-144 (152) alignment 
Range on Protein: 83-270
Range on HMM: 7-144/152.0
NKRKYIAAMAPLPATLRSWWRMIWQEQVTAIVMATPLNENGTDLCSRYWapspgqkikcmnmfvrtmatsdvkdkgylrtllqieaedgekrQLMHFWMY
.....||. .|.| || ..|||... ..|.||| | | |.| . | .|.                                           | .|... 
mpfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi...........................................qylhlpwp

DWNPRNPDSLLYCLRDMHLSEkQLAKGGPILVHDSAGVGRAGVIIATDFATellestGKADTLGIVRELRQDRMALVQTPEHYLLVQQ
| .. . . ||. | ...    .| ||||.||| ||||||.|...| .          . . . .|. .|. |.  |..|... ....
Dhgvpdlsqlllflllfiekl.aldkggpvlVHCsaGvgRtgtlvaaylml......lgvsleeavalvrekRpgavpnpgqlrflye
0049772 (Phosphotyrosine protein) phosphatases II 39-274 1.3e-27 92.8 In-house 44-278 (314) alignment 
Range on Protein: 39-274
Range on HMM: 44-278/314.0
VRNHKYNRYADVLPTPaTRVPLAELDSDPtTAYINANFVRGAhnnkRKYIAAMAPLPATLRSW----------WRMI--WQEQVTAIVM-----------
..|.. ||| |.|| . .|| |  |. .  ..||||..|.|     .|.||. .||. |. .           |||.  .. .|  |||           
flnrdknryldilpad.nrvilpglpvsg.sdyinasyvdgf....lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivmsrdevladels

----------ATPLNENGtdlcsrywapspgqkikcmnmfvrtmATSDVKDKGYLRtllQIE--AEDGEK--RQLMHFWMYDWNPRNPDSLLYCLRDMHL
           ..| .||                          .  ...|  .|.   ..   .|. |.   ..... ..|...  .. .. .|. .. 
rLdaAlgKtpllildgng..........................neptaadlellk...eelydpelferlgikylripvpDgsaplledfdeflefiee

SekqlAKGGPILVHDSAGVGRAGV--IIATdfateLLESTGKaDTLGIVRELRQDRM-----ALVQTPEHYLLVQQAIRL
      ||||.||| .||.||.|.  ..|      |.   |  .   .....|. |.      .....|.|. . .|.. 
a....dkggpvlvHCkaGkgRtgtfvvaay.....lmkllgv.sleealedvrlkRpinpnpgfieqleqyefilealle
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 41-272 1.3e-27 91.6 In-house 3-235 (237) alignment 
Range on Protein: 41-272
Range on HMM: 3-235/237.0
NHKYNRYADVLPTPATRVPLAELDSDptTAYINANFVRGAHNNKRKYIAAMAPLPATLRSWWRMIWQEQVTAIVMATPLNENGTDLCSRYWaPSPGQKIK
|.  |||...     .|| |    |.  . ||||....|     .|||||  || ..   .|.|.|||. . ||| | | |.    | .|| ||  |   
nkiknrygnivaydhsrvvlkgagsg..sdyinatylkgfdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkyw.pstdqpaa

CMNMFVRTMATSDVKDKGyLRTLLQIEAEDGEKRQLMH-FWMYDWN----PRNPDSLLYCLRDMHLSEKQLAKGGPILVHDSAGVGRAGVIIATDFATEL
   . |      .  |   .|.||  .    .. .|.| . .  |     |..  .||   ...    . ... || ..| ||||||.|...  |     
ygvltvslkkkeefsdyt.vrslllskrltlkevrlihqyqftswpdrgvpqqtaallrfrkniinrsphvsesgpwiihcsagvgrtgiflvidamlrq

LESTGKADTLGIVRELRQDRMALVQTPEHYLLVQQAI
 .     |    |  . .||  ..|| ..|....|.|
akekkvvdiynyvysieedrpyiiqtkdqyvfihqti
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 33-271 2e-27 91.0 In-house 35-266 (288) alignment 
Range on Protein: 33-271
Range on HMM: 35-266/288.0
TSIPAGVRNHKYNRYADVLPTPATRVPLAeldsDPTTAYINANFVRgAHNNKRKYIAAMAPLPATLRSWWRMIWQEQVTAIVMATPLNENGTDLCSRYWA
 .| . . |   .|| ..    .||| |     | .  ||.|| |  ....||. | | ||| .|.   |.|. ...|  ||| . | | | .    |. 
diidsfianptrdryenlprcditrvkls....ddpdfyiaanvvs.sakykrrlicaqaPlngtieelWkmllesdveyivmlcellekGkeksaeyfP

PSPGQKIKCMNMFVRTMATSDVKDKGYLRTLLQIEAEDGEKRQLMHFWMYDWNPR-NPDSLLYCLRDMHLSekqLAKGGPILVHDSAGVGRAGVIIATDF
   |.|..   .   .    .  ||    .||.|. |  ||  . .  . .|.    |.. |  || ..      .   ||.|| ||||||.| .| . .
sklGekarigrlctvvkkkradidklvkvsllriskegeekvivkilhlleWdddgvPenylsplrllevl...kslqkPivvhssaGvGrtgtlilili

ATELLESTGKADTLGIVRELRQDRMALVQTPEHYLLVQQA
| | | ..       .. .||..|.  .||   || | . 
aleslrlddflgirsllaklreerfkaiqtemqylyvhrc
subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 31-275 2.5e-27 90.2 In-house 27-268 (281) alignment 
Range on Protein: 31-275
Range on HMM: 27-268/281.0
DLTSIPAGVRNHKYNRYADVLPTPATRVPLAE-LDSDPTTAYINANFVRGAHnNKRKYIAAMAPLPATLRSWWRMIWQEQVTAIVMATPLNENGTDLCSR
|| ..     | | |||...     .|| |   .    .| || ||..|     || || .  |   |   .|||||||. |||||   . |   . |. 
dlctvfnqpvnnkknrylnipcldisrvqlkvkmpnknstdyihanyirspf.lkrgyiltqgpkketradfwrmiwqenttaivmlcqfletnrekcae

YWAPSPGQKIKCMNMFVrTMATSDVkDKGYLRTLLQIEAEdGEKRQLMHFWMYDWNP-RNPDSLLYCLRdmhLSEKQLAKGGPILVHDSAGVGRAGVIIA
|.       ..  .. | .   | | .|  . | |..  | || | . |.   .|   . |.|    |.   .  |  |.  | ..| ||||||.| ..|
yfprnahcclqfdklsv.syedstv.nkslvttrlnlsye.getrlithwlwkewpdwqvpessevmlk...ilrkirarstppvihcsagvgrsgtlma

TDFATELLEST-GKADTLGIVRELRQ-DRMALVQTPEHYLLVQQAIRLF
 . | . . |     |   ||  ||   | | ||| ..|.|. . .  |
veialqsihshftlpdikqivshlrvtgraasvqtlqqymliwkvlldf
subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 41-269 7.6e-27 89.0 In-house 35-263 (285) alignment 
Range on Protein: 41-269
Range on HMM: 35-263/285.0
NHKYNRYADVLPTPATRVPLAELDSDpttaYINANFVRGAHNNKRKYIAAMAPLPATLRSWWRMIWQEQVTAIVMATPLNENGTDLCSRYWAPSPGQKIK
|   ||||||     ||| | . | |    || |...|   ...  ||..  ||| ||  .|.||.||... ..|   | | | . |. |.    |. .|
npdlnryadvrcieetrvvlknhdrd....yihaswmrmpgkdqstyittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekcalyypeklgevvk

CMNMFVR-TMATSDVKDKGYLRTLLQIEAEDGEKRQL-MHFWMYDWNPR--NPDSLLYCLRDMHLSEKQLAKGGPILVHDSAGVGRAGVIIATDFATELL
  .  .  | .  .      | .|  |..||     | | .    | |    |.     .   .  .|   |  || || ||||||.  ..  |.||  .
fgkyeitlteckeeaiagtilnaltvintedasseplymnhvqvpwwpdqlapedarpmielykwvkkvnpkekpicvhcsagvgrtatfvgidyatiri

ESTGKADTLGIVRELRQDRMALVQTPEHYLLVQ
    . . | ||||.|  |.  ||.  ..|.. 
menpniemldivremramrfqavqshmqflfly
subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 42-264 1.3e-24 81.5 In-house 51-269 (301) alignment 
Range on Protein: 42-264
Range on HMM: 51-269/301.0
HKYNRYADVLPTPATRVplaELDSDPTTAYINANFVRGAhNNKRKYIAAMAPLPATLRSWWRMIWQEQVTAIVMATPLNENGTDLCSRYWAPSPGQKIKC
.. .||  |   | | |   |. .| . . | ||..     . ...||. .||..|   .| |. | .|  ||| .   |. .. |. | . ....|.. 
kdkhryptvPckPstav...evivdGkrvPihanwipts.GhphrfiatqgPlkntsedfwamlvqydvekivmlgqkvekleekceeylpvkisekldi

MNMFVRTMATSDVKDKGYLRTLLQIEAEDG--EKRQLMHFWMYDWNPRN-PDSLLYCLRDMHLSEKQlakGGPILVHDSAGVGRAGVIIATDFATELLES
    ...  .  . .|   .  |..|   |  . | ..|.   .|  |. | |   .   |.|  |      ||.|| |||.||.   |.|.. .  .|.
grfkikiknkelilnkkiskrtlevedstgkfatrtvthyqysewtdrgvPkshaelfdlmelvkks...ekPivvhcsaGiGrsvafigteylarevea

TGKADTLGIVRELRQDRMALVQTPEH
  . .    ...||..|   ||| . 
dptieltealkhlrehrwngvqtnsq
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 42-271 1.7e-24 81.0 In-house 56-284 (305) alignment 
Range on Protein: 42-271
Range on HMM: 56-284/305.0
HKYNRYADVlptPATRVPLAELDSDPTTAYINANFVRGAHNNKRKYIAAMAPLPATLRSWWRMIWQEQVTAIVMATPLNENGTDLCSRYWAPSPGQKIKC
   |||.||   |.    .  ||  . . || ||.|      ....|.|  ||  |.  .| |. |..|  |||     | |   |..||  . |.| . 
itknryqdv...pcqdqsavkldkpspsdyihanyvgcpmipekrficaqgpldqtidefwwmviqnkveqivmlcktvelgklkcaqywpaaqgeklel

MN-MFVRTMATSDV--KDKGYLRTLLQIEAEDGEKRQLMHFWMYDWNPRN-PDSLLYCLrdmHLSEKQLAKGGPILVHDSAGVGRAGVIIATDFATELLE
 . . |  .. |    .|     |||..    ..|  . |.   .|  |  |   |  |    |         ||.|| |||.||.| |.| ..  | . 
ksgivvenvsgskpmerdaeiqitllnltysgdqkmsvrhlqwtewpdrgvppckltsl...ellsairgskvpivvhcsagigrtgtivaieyilekia

STGKAD-TLGIVRELRQDRMALVQTPEHYLLVQQA
   ..     .|. ||..|   .|.  .|| ... 
enkpcppmpelvkalrdqrafsiqndvqylfihrv
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 37-270 1.9e-24 81.2 In-house 37-271 (307) alignment 
Range on Protein: 37-270
Range on HMM: 37-271/307.0
AGVRNHKYNRYADVLPTPATRVPLAeLDSdPTTAYINANFVrGAHNNKRKYIAAMAPLPATLRSWWRMIWQEQVTAIVMATPLNENGTDLCSRYWAPSPG
|   | . ||| ||     .|. .  .|   .. || ||.. |   . .|.|.|  || .|  |.| |. ||.| ...|   . | .   | .||    |
afsantdknryqdvkcqdkgrivvk.fdg.lasdyihanyl.giaikpkkficaqgplentqysfwamaiqekvesvimlckvielakikceqywpleeg

QKIKCMN----MFVRTMATSDVK-DKGY-LRTLLQIEAEdGEKRQLMHFWMYDWNPRNPDSLlyCLRDMHLSEKQLAKGGPILVHDSAGVGRAGVIIATD
||    .    . |  . .  .  |. .   | |...   .. | . |.   .|  |    .   |  . | |    .  |..|| ||||||.| |.|  
qklvfgeapntisvanlgakklapdedlinvttlkvdwa.qksrtiqhlqwenwpdrgvpqi..nltainlleavrydtnpvvvhcsaGvGrsGtivais

FAT-ELLESTGKADTLGIVRELRQDRMALVQTPEHYLLVQQ
.    ...     |   .|.|||..|   .||   || . .
lvqdkmiaGinckdmkklveelrsqrhyaiqteaqylylhr
subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 39-287 2.5e-24 80.9 In-house 16-270 (290) alignment 
Range on Protein: 39-287
Range on HMM: 16-270/290.0
VRNHKYNRYADVLPTPATRVPLAELDSDPTTAYINANFVRGAHNnkRKYIAAMAPLPAT-------LRSWWRMIWQEQVTAIVMATPLNENGTD----LC
|..|. .. ..|    ||||.| .  .  .  || ||.|  ...   . |.  .|. ..       . ..| |. ||.|. .||    .|. ..     |
vkkhemdqRlevpLveatrvvLkgygkrfnddyiHAnrvtcpng..lrliltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaC

SRYWAPSPGQKIKCMNMFVRTmaTSDVKDKGYLRTLLQIEAEDGEKRQLMHFWMYDWNPRNPDSLLYCLrdMHLSEKQLAKGGPILVHDSAGVGRAGVII
..|   | |...|  .. |.   .| .|...  .  | .. .|.|. .. | .. .||..|       |  ..| .|  |.. |..||.  |. |  .. 
akYvpesvgeelkfkgltvkC..kskekeddvetRelvvkfddeeeftvtHsllkgWnklnvqedtktl..lsliqkvkasktpvivHcvdGiSrsAala

ATDFATELLE-STGKADTLGIVRELRQDRMALVQTPEHYLLVQQAIRLFARTAGVALSEIE
| . .  ..  ..|.  .  .. .||. |  ...... .  |  .| | |  .. . .| |
aiilgyQkiaetsgsvkledvlkalrkqralaitsalelafvdagivllaievldqfaeee
subfamily_egg_pd Subfamily egg 54-279 4.1e-24 79.8 In-house 53-273 (307) alignment 
Range on Protein: 54-279
Range on HMM: 53-273/307.0
PATRVPLAELDSDPTTAYINANFVRGAHNnKRKYIAAMAPLPATLRSWWRMIWQEQVTAIVMATPLNENgtDLCSRYWAPSPGQKIKC--MNMFVRTMAT
  .|| |       .  .| || |.|      ..| | |||  |   .|||..||.|  ||| |   |.  . |  ||  .. . ..    .. . ..  
dssrvklelrrGqylddfihanrvkGkpl.lnefilaqaplkntvddfwrmvfqeevqyivmltsrkes..erceyywpkaesdslvtvpGslrienlkv

SDVKDKGYLRTLLQIEAEDGEKRQLMHfWMYDWNprNPDSLLYCLRDMHLSeKQLAKggPILVHDSAGVGRAGVIIATDFAT-ELL-ESTGKADTLGIVR
 .  |  .  | |..   | |.| | | | .|.|  |   . . || . .  ..|.|  |..|.|  || .|....| . |  .||   . |   |  | 
dskadplfrvtklklvGgddeerfleh.wqgdvn..nssdvysplrvlrkl.rnlsk..pvvvqdilGvskaatlvaieiallsllrGpitkslvlravv

ELRQDRMALVQTPEHYLLVQQAIRLFARTA
 ||. |   |...  ||.| . . .| |  
flrlrrrlsvesvllylfvyrlvlfffrdv
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 43-185 1.3e-23 78.3 In-house 35-175 (297) alignment 
Range on Protein: 43-185
Range on HMM: 35-175/297.0
KYNRYADVLPTPATRVPLAEldSDPTTAYINANFVRGAH-NNKRKYIAAMAPLPATLRSWWRMIWQEQVTAIVMATPLNENGTDLCSRYWAPSPGQKIKC
. ||| |.| |  ||| |    . . . ||||..|   . ... ||| |  || ||.  .|.......| .||| . |.|.| | |  ||  . ... |.
rknryrdilatddtrvkllr..viterdyinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmvaklqedGrdkcapywpsvvqerlka

MNMFVRTMA-TSDVKDKGYLrTLLQIEAEdGEKRQLMHFWMYDWN
 .. |  .. |||  |. .| | ||.     |.|.. |     | 
gdvvveflsstsdefdrvil.telqliyr.sesrvvrhvqflswp
0044763 (Phosphotyrosine protein) phosphatases II 52-272 3.5e-23 77.6 In-house 1-167 (178) alignment 
Range on Protein: 52-272
Range on HMM: 1-167/178.0
PTPATRVPLAELDSDPTTAYINANFVRGAhnnkrKYIAAMAPlpatlRSWWRMIWQEQVTAIVMATPLNENGTDLCSRYWAPSPGqkikcmnmfvrtmat
| . ||| | .|   ... ||||... .       |...  |      ......... .|.||. |.  |.|   | .||  . |               
pldrtrvllsnleglersdyinaseilpg.....lylgslpp.....addlellkelgithivnlteelelgflkcdpywpeeag...............

sdvkdkgylrtllqieaedgekRQLMHFWMYDWNPRN-PDSLLYCLRDMHLSEKqlAKGGPILVHDSAGVGRAGVIIATDFATELlestgKADTLGIVRE
                       | .|. . |... . .. .| ... ..   .   ||||.||| ||||||.|...| .   .|     . .   ....
......................iqylhipipDhgvpdllehflefvefieeald..ekggpvlVHCsaGvgRsgtlvaaylmkkl.....glsleeaiel

LRQDRMaLVQTPEHYLLVQQAI
.|. |.  |..|...  ...  
vrerRp.ivpnpgqlrqLyefe
0051082 (Phosphotyrosine protein) phosphatases II 69-269 2.7e-21 71.2 In-house 3-146 (151) alignment 
Range on Protein: 69-269
Range on HMM: 3-146/151.0
TAYINANFVRGAhnnkrkYIAAMAPLPatlrSWWRMIWQEQVTAIVMATPLNENGtdLCSRYWAPSPgqkikcmnmfvrtmatsdvkdkgylrtllqiea
. |||...| |       ...  .||.      ...........||. ... |.|   | .|.                                     
sdyinfsyvtgg......lyrsggpla....dflellkelgiktivnlrseeerg..ycpeylpelg.................................

edgekRQLMHFWMYDWNPRNPDSLLYCLRDMHLSEKQlAKGGPILVHDSAGVGRAGVIIATDFATelLEstgkADTLGIVRELRQDRMALVQTPEHYLLV
     ....|... || . . . ..  .....    .  |.||.||| |||.|| |...| .     |      .   ...|.|. |. .||.....|..
.....ievlhipildwpdpglplsfdavleflellld.kkngpvlvHCsaGkgRTGtlvalylml..lg....vsleealeeyrlkrpgvvqpnqqflfq

Q
 
l
PTPc_DSPc_SM00012 177-272 6.4e-20 66.7 In-house 3-103 (105) alignment 
Range on Protein: 177-272
Range on HMM: 3-103/105.0
MHFWMYDWNPR----NPDSLLYCLRDMHLSEKQLAKGGPILVHDSAGVGRAGVIIATDFATELLEST-GKADTLGIVRELRQDRMALVQTPEHYLLVQQA
.|.....|       ..||.|  ||... .... ....|..||.||||||.|...| | . . ||.. .. | . ||.|||. |. .||| | || . .|
khyhytgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqylflyra

I
.
l
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 34-154 5.6e-19 63.1 In-house 40-175 (350) alignment 
Range on Protein: 34-154
Range on HMM: 40-175/350.0
SIPAGVRNHKYNRYADVLPTPATRVPLA--------ELDSDPTTAYINANFVRGA-----HNNKRKYIAAMAPLPATLRSWWRMIWQEQVTAIVMATPLN
 .  ||.    ||| ..||   .|| |            |  |  |||||... .      | . ||||. |||| |.  ....| . .|. |.. |.. 
ilseGvelfaknrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvkvilsltsdv

ENGTDLCSRYWAPSPGQ--KIKCMNMFVRTMATSDV
|.. . | |||     .  ..|  ..   .| . |.
elnlekcyrYWqegsydditvklaskwenimginds
subfamily_ptpA1_pd Subfamily ptpA1 40-134 9.1e-19 62.5 In-house 46-138 (418) alignment 
Range on Protein: 40-134
Range on HMM: 46-138/418.0
RNHKYNRYADVLPTPATRVPLAELDSDPTTAYINANFVRGAHNnkRKYIAAMAPLPATLRSWWRMIWQEQVTAIVMATPLNENGTDLCSRYWAPS
.|   |||...||   ||| | ...    . |||||.. ||.   ...|..  ||| |.  .|||.|....  ||| .  .||    | |||   
hntsknrytnilpvnhtrvqlkkiqdkegsdyinanyidgayp..kqfictqgplpntiadfwrmvwenrcriivmlsresencrikcdrywpeq
0048076 (Phosphotyrosine protein) phosphatases II 168-272 1.4e-14 49.5 In-house 39-139 (145) alignment 
Range on Protein: 168-272
Range on HMM: 39-139/145.0
AEDGEKRQLMHFWMYDWNPRNPDSL-LYCLRDMHLSEKQLAKGGPILVHDSAGVGRAGVIIATDFATEllestGKADTLGIVRELRQDRMALVQTPEHYL
 .....|. .... ..|  ... .|  . |. ... |. |..|||.||| ||||||.|...| .   .      . .   .....|. |.  |..|... 
elellerlgiqylylpwpDhgvpdllellleflefieealkeggpvlVHCsaGvgRtgtlvaaylmll.....lgvsleealelvrsqrpgavpnpgqlr

LVQQAI
 .....
flyefe
subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 40-136 2.1e-14 47.8 In-house 51-144 (310) alignment 
Range on Protein: 40-136
Range on HMM: 51-144/310.0
RNHKYNRYADVLPTPATRVPLaELDSDPTTAYINANFVRGAHnNKRKYIAAMAPLPATLRSWWRMIWQEQVTAIVMATPLNENGTDLCSRYWaPSPG
.. . |||.||.   ..|| | ..|      || ||.|.  .  .  .| .  ||  |.  .||||.||.  .|..     |.|   |  || || |
kymhknrysdvvcldtsrvkl.kidksryedyihanyvktny.lrstficsqgplqhtiidfwrmifqeraesilllckvgeegrpkcvgyw.pslg
subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 42-281 5.3e-14 46.6 In-house 44-281 (312) alignment 
Range on Protein: 42-281
Range on HMM: 44-281/312.0
HKYNRYADVLPTPATRVPLAEldsDpTTAYINANFVRGAHNNKRkYIAAMAPLPATLRSWWRMIWQEQVTAIVMATPLNENGTDLCSRYWAPSPGQkIKC
.  ||| ..      |  ||    |    || ||||.   . .| .... .||  |   .|..      |.|.. . . |.|.. |..| .   |  .. 
kdlnrypniqcwdrgrftlag...d.enfyihanfvkictkper.fvctqgplentcthfwqlalslgstsiillcgfvedgsekcakyisdivgf.vdl

MNMFVRTMAT------SDVKDKGYLRTLLQIEAEDGEKRQLMHFWMYDWNPR-NPDSLLYCLRDMHLSEKQlaKgGPILVHDSAGVGRAGVIIATDFATE
 .  | |            |||   | |  .    |.. .| |.    |     |||   .|| .    |.  |  |.. | ||||||.| ..  .    
edhrvyteycteieiggkskdkithrvlkvvvkatgqesklnhyqwaswpdhgmpdscdtalrllsavkkd..k.kpviahcsagvgrtgtlaliesmia

LLESTGKADTLGIVRELRQDRMALVQTPEHYLLVQQAIRLFARTAGV
 |    | .   .   ||.||   |..  .|. . ...  |  . |.
alrhprkqnvkdsfvllrkdrarsvrvfpqyvyalrcvleflyskgl
subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 81-270 7.2e-14 46.4 In-house 1-198 (199) alignment 
Range on Protein: 81-270
Range on HMM: 1-198/199.0
HNNKRKYIAAMAPLPATLRSWWRMIWQEQVTAIVMATPLNENGTDLCSRYWAPSPGQKIKCMNMFVRTMATSDVKDKGYLRTLLQI-EAEDGEKRQLMHF
|. .|.|||.  ||  |.  .|.|.|.     |||    . |     . ||. .     |  .. | | . .   |      .|    .     |.. |.
hkgqrryiatqhplretmadfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishy

WMYDWNPR-NPDSLLY---CLRDMHLSEKQ-LAKGGPILVHDSAGVGRAGVIIATDFATELLES--TGKADTLGIVRELRQDRMALVQTPEHYLLVQQ
 .  |. .  |.  |.    .    .| |    |  |..|| | | | .||..| |      |   |   | . . . ||| |  .. . .|| .. |
qftswkekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiyq
0048179 (Phosphotyrosine protein) phosphatases II 173-270 1.9e-13 45.8 In-house 49-139 (144) alignment 
Range on Protein: 173-270
Range on HMM: 49-139/144.0
KRQLMHFWMYDWNPRNPdsLLYCLRDMHLSEKQLAKGGPILVHDSAGVGRAGVIIATDFATellesTGKADTLGIVRELRQDRMALVQTPEHYLLVQQ
  |..|. . |... .   | ..|. ... |. |..|||.||| ||||||.|...| .        . . .   .....|. |.  |..|...  ...
giqylhlpwpDhgvpdl..lellleflefieealeeggpvlVHCsaGvgRtgtlvaaylmk.....klglsleealalvrsrrpgavpnpgqlrfLle
subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 84-270 2.1e-13 44.9 In-house 3-197 (198) alignment 
Range on Protein: 84-270
Range on HMM: 3-197/198.0
KRKYIAAMAPLPATLRSWWRMIWQEQVTAIVMATPLNENGTDLCSRYWAPSPGQKIKCMNMFVRTMATSDVKDKGYLRTLLQI-EAEDGEKRQLMHFWMY
.|.|||.  ||  ||  .|.|.|.     |||    . |     . ||. .     |  .. | | . .   |      .|    .     |.. |. . 
qrryiatqhplretladfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqft

DWNPR-NPDSLLY---CLRDMHLSEKQ-LAKGGPILVHDSAGVGRAGVIIATDFATELLES--TGKADTLGIVRELRQDRMALVQTPEHYLLVQQ
 |. .  |.  |.    .    .| |    |  |..|| | | | .||..| |      |   |   | . . . ||| |  .. . .|| .. |
swkekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiyq
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 173-291 5.3e-13 43.1 In-house 92-208 (440) alignment 
Range on Protein: 173-291
Range on HMM: 92-208/440.0
KRQLMHFWMYDWNPRNPDSLLYCLRDMHLSEKQlAKGGPILVHDSAGVGRAGVIIATDFATELLESTGKADTLGIVRELRQDRMALVQTPEHYLLVQQAI
|.  .. |     |.    .|  ..|.  |... |  ||.||| |||.||.||||| |      . . . | . ..  .|..|  .|||||.| .|..|.
kqyhyqgwpdkgvpkfagpvlkmiqdvnesqek.agngpllvhcsagagrtgviiavdsilreakrsdqidifsfinsmrnnrpqmvqtpeqyafvheav

rLFARTAGVALSEIEDIHT
 | .  .| .|   .||  
.legllcgdtlileddite
subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 75-262 5.5e-13 43.6 In-house 23-207 (255) alignment 
Range on Protein: 75-262
Range on HMM: 23-207/255.0
NFVRGAHNNKRKYIAAMaplpaTLRSWWRMIWQEQVTAIVMATPLNENGTDLCSRYWAPSPGQKIKCMNMFVRTMAtsdVKDKGYLRTLlQIEAEDGEKR
. |.  ...||| . ..     |.  ....| | . . .|| . ..|.| . ||.|.     .| |  .. | |        .  |||| .| .. |||.
ehvkPekdkkrknlysl.....tvdkfyqtivqtktevvvmlcdfaeegvekcssyfplekdeklkladvnvtttk...ssadvvlrtl.eitstlgekk

---QLMHFWMYDWNPR----NPDSLLYCLRDMHLSeKqlakggPILVHDSAGVGRAGVIIATDFATE-L-----LESTGKADTLGIVRELRQDRMALVQT
   .. |.    |  .    ..  .|. |. .. | |      ...|| |.|.||.   . ....   .       .|.. | | ...|||. | . ..|
kthtvkhysykGWieknaPelareilnilkvvrds.k......svvvhCstGiGrsaafvlaelvyqkmirsldttetveldylslleelrskrkraiht

P
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subfamily_CG42327_pd Subfamily CG42327 208-277 1.5e-12 41.8 In-house 246-316 (319) alignment 
Range on Protein: 208-277
Range on HMM: 246-316/319.0
KGGPILVHDSAGVGRAGVIIATDFATELLEST-GKADTLGIVRELRQDRMALVQTPEHYLLVQQAIRLFAR
. ||. || | ||||.|..||.|.| . || .    |   .|  .|.||   |.| | | .. . .  .|.
sqGPlvvhcsdGvGrtGlviasdiairsleeskrsvdiPqlvssvrrdrasavltkeqyefiykvlseyak
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 34-134 1.6e-12 41.4 In-house 41-156 (349) alignment 
Range on Protein: 34-134
Range on HMM: 41-156/349.0
SIPAGVRNHKYNRYADVLPTPATRVPLAE--------------LDSDPTTAYINANFVRGAH-NNKRKYIAAMAPLPATLRSWWRMIWQEQVTAIVMATP
 .  ||.    ||| |.||   .|| | .               ||     |||||... .. . ..|||| .||||.|.  ....|  ..|  ..  . 
ilseGvelfaknrykdilPyehsrvklkkslksskvikastsesdsgklddyinanylkltrisvekkyiatqaPlPstvddfykvillngvklvlsLnd

LNENGTDLCSRYWAPS
 .|.. . | .||   
dkelslekcdiywqel
subfamily_hpo-7_pd Subfamily hpo-7 35-262 1e-10 36.0 In-house 24-213 (263) alignment 
Range on Protein: 35-262
Range on HMM: 24-213/263.0
IpagvrnhkynryadvlptpatrvplaeldsdpttayinANFVRGAHNNKRKYIAAMapLPATLRSWWRMIWQEQVTAIVMATPLNENGTDLCSRYWAPS
                                       .. ..  ...||| . ..  |  |. . ...| | . . .|| .  ||.| . ||.|.   
c......................................tehfkPekdkkrknlysl..lvqtidkfyqtivqtktevvvmLcDfneegvekcssyfPle

PGQKIKCMNMFVrtmATSDVKDKGYLRTLlQIEAEDGEKR---QLMHF----WMYDWNPRNPDSLLYCLRDMHLSeKqlakggPILVHDSAGVGRAGVII
  .| |  |. |   .|..|...  |.|| ..    |||.   .. |.    |.   .|... . |. |.    | |      .. || |.|.||.    
kdekqklanvnv...cttkvqsdvllktl.ellstlgeKkkthtvkhysykgWiekndpelareilnilkvarns.k......slvvhcstGiGrsaafs

ATDFATE-L-----LESTGKADTLGIVRELRQDRMALVQTP
 ....   .       ||.. | | ...|||. | . ..||
vaElvyqkmirsldttstveldylsLleelrssrkraihtP
subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 41-277 1.3e-10 35.2 In-house 51-286 (302) alignment 
Range on Protein: 41-277
Range on HMM: 51-286/302.0
NHKYNRYADVLPTPATRVPLAEldsdPTTAYINANFVRGAHNNKRKYIAAMAPLPAT--LRSWWRMIWQEQVTAIVMATPLNENGTdLCSRYWAPSPGQK
| |.|.  ||    ...| |..        |.||  |   . ..  ..| .. .  .  . ..|||..||... .|..   .|  .   | ..    |. 
nlkknqsedvpildsnlvklea....epdsyvnaskvevPeltrsiilaQlpkvdsedsveeFWrmvfqekivsvvilvgeeelkk.tlselfpkksgdy

IKCMNMFVRTMATSDVKDKGyLRTLLQIEAEDGEKRQLMHFWMY-DWNPR-NPDSLLYCLRDMHLS-EKQLAKGGPILVHDSAGVGRAGVIIATDFATEL
 .  .||| .   . ....   |  . .  |.     |.   .   |..   |..     . ..   .|.     ....    |.||||....   | | 
keygkmfvNnrkVekaeeek.tryviEvlPegcsnsvlanvyvltnWkqkkvpvkyaeliktaakvfakkikadentvivSknGaGRagafltlavavek

LESTGKADTLGIVRELRQDRMALVQTPEHYLLVQQAIRLFAR
|..  .     ||. .|..| . |.. . |  .  |. |. .
lqkgkepnikeivksiRsqRpravdslkQyvslyialllyik
subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 85-267 3.6e-10 33.8 In-house 91-281 (302) alignment 
Range on Protein: 85-267
Range on HMM: 91-281/302.0
RKYIAAMAPLPATLRSWWRMIWQEQVTAIVMATPLNENGTDLCSRYWAPSPGQKIKCMNMFVRTMATS----DVKDKGYLrTLLQIEAEDGEKRQ-----
 .    . |   ||  .| .| | .|. .|  . . |..   |. |..   |...|  .  |.|.       .  ||  . .| ..| .. .|..     
kvskkpivpkkstlekhwalieqynvaivvqlcsfvedeekkcaeyysdkvggelkfgrytvktvsvktdleeftdkksf.klytveiknekkkkkvkkt

--LMHF--WMYDWNPRNPDSLLYCLRdmhLSEKQLAKggpILVHDSAGVGRAGVIIATDFATELLESTGKADTLGIVRELRQDRMALVQTPEH--YLL
  ...|  |     |..... |  |.     |    .   .||| ||||||.| ..|  .  .|      .| | ||  .|| |   ||. .   |||
vdilafsawpdhGapkeaytaldilk...fcesykkn...vlvhcsaGvGrtGtlvaikyGiqlcskkkvtdllsivlpvrqcryGavqdeqqliyll
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 209-271 8.7e-10 32.9 In-house 228-290 (297) alignment 
Range on Protein: 209-271
Range on HMM: 228-290/297.0
GGPILVHDSAGVGRAGVIIATDFATELLESTGKADTLGIVRELRQDRMALVQTPEHYLLVQQA
  ..||| ||||||.||.. .|   . |      |.  |.. ||. |  |||| | . |. .|
nayllvhcsaGvGrsGvvvlsdvilaklrkkripdvaailsilreqrarlvqtleqfellyda
subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 41-115 2.1e-09 31.4 In-house 45-115 (347) alignment 
Range on Protein: 41-115
Range on HMM: 45-115/347.0
NHKYNRYADVLPTPATRvplAELDSDPTTAYINANFVRgAHNNKRKYIAAMAPLPATLRSWWRMIWQEQVTAIVM
..| .  . |. .|          .|.. .||||  ..   | ...|| .  ||| |.| .|.|.   .|| .| 
dvklidatrvvlspeks...knsraddvetyinashik.fdnaskeyiltqyplpdtvrdfwkmvsvtkvtqvvt
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 176-275 4.2e-09 30.6 In-house 217-343 (350) alignment 
Range on Protein: 176-275
Range on HMM: 217-343/350.0
LMHFWMYDWNPR----NPDSLLYCLR------DMHLSE--KQLAKGGPILVHDSAGVGRAGVIIATDFATE---LLESTG----KADT--------LGIV
.... .  |.      || |.|  |       |   .|   . |.. ||||| ||||||.|.... |.  .    || .     | |.          ||
vyqlqvknWkDlslllnPesilqalevkndliddlfaeshldnarsspilvhCsaGvGrtGtlvtlDsllsdfeilenltkesrkldvaaktrDlisiiv

RELRQDRMALVQTPEHYLLVQQAIRLF
 |||. |. .||. . .. . .|.. .
nelrkqrismvqnldqfifiYeallfy
subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 208-278 1.9e-08 28.2 In-house 222-292 (310) alignment 
Range on Protein: 208-278
Range on HMM: 222-292/310.0
KGGPILVHDSAGVGRAGVIIATDFATELLESTGKADTLGIVRELRQDRMALVQTPEHYLLVQQAIRLFART
. || .|| |||..| .|..| ... . |.   | |.  .. ||...|.  .||.  ||....   .|||.
rhgpcvvhcsagkdrlyvvvalklkidkldrglkvdaeevktellksraiciqtelqyliidrvriifarg
subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 39-261 2e-08 28.2 In-house 45-264 (303) alignment 
Range on Protein: 39-261
Range on HMM: 45-264/303.0
VRNHKYNRYADVLPTPATRVPLAelDsdptTAYINANFVRgaHNNKRKYIAAMAPLPATLRSWWRMIWQEQVTAIVMATPLNEnGTDLCSRYWAPSPGQK
|.| . ||..||.    ..| |.  |    ..|| |...    . ..| | .  ||. |   .|.|| ...|  ...    .|   .|   .  |   . 
vknmdknrfvdvicldhskvkls..d....ssyihasyle..ldsskkailtqlplshtaadfwqmiieqkvkcvlllltdse.ydklggdsvfprnqdf

IKCMNMFVRTMATSDVK-DKGYLRTLlqIEAEDGEKRQLMHFWMYDWNPRN--PDS----LLYCLRDMHLSEKQLAKGGPILVHDSAGVGRAGVIIAtdF
.|  . ..|      |.  .|.   .  .   .|. . ..|   |.  | |  |      ..  . ..    .. ... | .    .|.|||| .    |
lkfeersirvgefkrvelgdgwvlkv..lsvsngdyksflhvhhykawphnsipsdgspkfvkqiwqlqsvlrkysdstptvymslsgcgragtfal..f

ATELLESTGKADTLGIVRE---LRQDRMALVQT
 |  |    .  .| .|.    .|. |.  || 
etahlslhseqasldlvkclenvrngrlhavqn
subfamily_Cele-PTP-5_pd Subfamily Cele-PTP-5 98-261 1.3e-06 21.2 In-house 131-294 (346) alignment 
Range on Protein: 98-261
Range on HMM: 131-294/346.0
LRSWWRMIWQEQVTAIVMATPLNENGTDLCSRYWAPSPGQKiKCMNMFVRTM-ATSDVKDKGYLRTLLQIEAEDGEKRQLMHFWMYDWNPRNPDSLlYCL
.  .| ||.|||.  . .  | .       | .     | .    .||.    |      | |   .|     |    |. |   .    . | .|   .
vedfwymiyqeqihlvylmvpddklkntttslfndenggyq.ytgkmfinnrradvsgdpkeytievlpegnsdsvicqvhhhapwkhlqqppktl.pii

RDM--HLSEKQLAKGGpILVHDSAGVGRAGVIIATDFATELLESTGKADTLGIVRELRQDRMALVQT
. .   |||||. . | . |    | |||  .| . .| . |.   . . . |.....|.|   |..
kmihqflsekqvqnag.vcvvslfgcgracsfigalyainqlnngiepniceimknikqqrpggves
subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 41-122 2e-06 21.6 In-house 96-174 (244) alignment 
Range on Protein: 41-122
Range on HMM: 96-174/244.0
NHKYNRYADVLPTPATRVPLAELDSdpTTAYINANFVrGAHNNKRKYIAAMAPLPATLRSWWRMIWQEQVTAIVMATPLNEN
|   || .  ||    ||||..       .|||| || |      .|| .  ||  |   .|.|. .  |  .|.   ..|.
nswknregaglpfdfnrvplskgsm..gntyinasfv.gclgrtaeyiltqhpladtsmdfwkmmlerhvnvlvvlgsveee
subfamily_eak_pd Subfamily eak 48-185 8.5e-06 19.4 In-house 58-190 (332) alignment 
Range on Protein: 48-185
Range on HMM: 58-190/332.0
ADVLPTPATRVPLAELDSDPtTAYINANFVRgAHNNKRKYIAAMAPLPATLRSWWRMIWQEQVTAIVMATPLNENGTDLCSRYWAPSPGQKIKCMNMFVR
 ...|     | |.    ..   ||||  .    .  |||| . ..    .  .|.|. ...  |||.     |.. .   .|.     ...|   . | 
vkivpydrylvrltssqlnr.lGyinaslae.fsevGrkyiltGiasedkvfafwqmvleqkspaivqlledvelkleksdkyfpdktreelkfGildve

TMATsdVKdKGYLRTLLQIEAEDGEKRQLMHFWMYDWN
.     || .. |.| | .     |  ...|. .. | 
rkef..vk.rniletrllelskGnethrvlhykvfGwt