Gene MbrePTP-sf2-7 in Monosiga brevicollis

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily MbrePTP-sf2
Protein sequence
ID Type Fasta BLAST phosphatome Note
MbreP045_AA protein Get Run
MbreP045_AA_10-277 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 15-282 6e-104 341.8 In-house 1-270 (270) alignment 
Range on Protein: 15-282
Range on HMM: 1-270/270.0
FMRLDKQRPSPEQLPTWATDAALNRSLGVLPSPRTRVCVragdPPLNINSRGAYINANFVRGFDHEHCYYIAAMSPTATSLLQFWLMIWENKVLSILMLS
|..|||...|...||..|....|||. ..||||.|||..    ..|. .|. ||||||.|||||.|...|||||.|..|.| .|| ||||.|| .|.|..
fkeldkeetsesdlpeaargkklnRyadiLPsPatRvrl....eeleedsataYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmtt

KITEQNRDQCAVYWPTEPGVTVKLPNGMLATCTSKEEKHHGSILRRITLK-WGEEVRDLrHWQYVDWPEDSAVPMHGSSTSPDDLMHTLRAM--WVVRH-
...|..|..|..|||.||. .||| .|........|||..|.||.|..|. .||| | . |..|..||.........||.|.|.|...|||.  .  .. 
gleEkgrkkCerYWpaepkekvkledgkikvlalseekeegyiltrlrleekgeerrlv.HfwyntWpdhgvpreedsslstdqllkmlravrrsekeld

---PFLVHCADGIERTGLAIALDIGMQTLSRTNSCDPIKVIDELRQDRPECISHSVQYALLYKAMLIHCHRRSQR
   |.||||..|..|||..|||||....|..|...|....|.|||.||.....|..||..||||......||..|
kaePllvHcsaGvgRtGtlialDiavrlLeetkkvdvlaiieelRkdRmalvqhpeqyeflykavveyaerrakr
0050432 (Phosphotyrosine protein) phosphatases II 27-279 2.3e-56 186.7 In-house 61-302 (308) alignment 
Range on Protein: 27-279
Range on HMM: 61-302/308.0
QLPTWATDAALNRSLGVLPSPRTRVCVragdpplniNSRGAYINANFVRGFD-HEHCYYIAAMSPTATSLLQFWLMIWENKVLSILMLSKITEQNRDQCA
    .     .||.  .||  ..||..         ..   ||||..|.|.. .  . .||. .|. ...  || |.||..|  | || |..| .| .||
svallpenkdkNrykdilpydhsRVkl.........degsdYInAsyvdgyssklprkfIatqgPlpntvedFwrmvweqnvrvIvmLtklvengrekca

VYWPTEPGVTVKLPNGMLATCTSKEEkHHGSILRRITLKW--GEEVRDLRHWQYVDWPedsavpMHGSSTSPDDLMHTLRAMWVV--RHPFLVHCADGIE
 |||.|.| ...  ...  |..| |. ... ..| ..|..  ..|.| ..|..| .||       ||  .||..|.. |...  .   .| .||| .|. 
qYwplelgggsleygkftvtllseev.lddytvrtleltnlgdgesrtvthfhytnWp......dhgvPpspeilldflelvrkslpggpivVHCsaGvG

RTGLAIALDIGMQTLSRTNSCDPIKVIDELRQDRPECISHSVQYALLYKAMLIHCHRR
|||  ||||. .. | ... .|. ...  ||. || ..    || .||.|.| .....
RtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtpeqylflyralleylklk
0046845 (Phosphotyrosine protein) phosphatases II 14-278 1e-54 181.2 In-house 5-276 (284) alignment 
Range on Protein: 14-278
Range on HMM: 5-276/284.0
RFMRLDKQRPS---PEQLPTWATDAALNRSLGVLPSPRTRVCVRAGDPPLNINSrgaYINANFVRGFD----HEHCYYIAAMSPTATSLLQFWLMIWENK
 |..| .. ..   .     .     .||.  .||  ..||...  |. |. ..   ||||..|.|.|    . .. .||.  |. ...  || |.||..
efeellsltvklllslsvallpenlsknRykdilpydhsRVklksldgdledsd...YinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweqn

VLSILMLSKITEQNRDQCAVYWPTEpGVTVKLpNGMLATCTSKEEkHHGSILRRITLKW---GEEVRDLRHWQYVDWPedsavpMHGSSTSPDDLMHTLR
|  | || ...| .| .|| |||.| | .... ...  |..|.|. ... ..|...|..   ..|.| ..|..| .||       ||  .||.||.. ||
vrvIVmltelvengrekcaqYwple.gevlty.gdftvtllseev.kddytvrtleltnlgytgesrtvthfhytswp......dhgvppspedlleflr

AMWVV------RHPFLVHCADGIERTGLAIALDIGMQTLSRTN---SCDPIKVIDELRQDRPECISHSVQYALLYKAMLIHCHR
..  .       .| .||| .|. |||  ||||. .. | ...    .|. ...  ||. || ..    || ..|.|.| .. .
lvrellenlpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyealleylkl
0051299 (Phosphotyrosine protein) phosphatases II 27-276 1.4e-52 174.3 In-house 42-286 (288) alignment 
Range on Protein: 27-276
Range on HMM: 42-286/288.0
QLPTWATDAALNRSLGVLPSPRTRVCVRAGDPplniNSRGAYINANFVRGFDHEHCyYIAAMSPTATSLLQFWLMIWENKVLSILMLSKITEQNRDQCAV
    .      ||.  .||  ..||...  |.    .. . ||||....|.....  .||.  |. ...  || |.||..|  | || |..| .| .|| 
saallpenleknRysdilpydhsRVkLsvldg....vegsdYinAsyidgynlkrk.fIatqgPlpntvedFWrmvweqnvrvIvmltklvelgrekcaq

YWPTepGVTVKLpnGMLATCTSKEEKHHGSILRRITLK------WGEEVRDLRHWQYVDWPEDSAVPmhgsstSPDDLMHTLRAMWVV----RHPFLVHC
|||.  | ....  | .  .. .||.... ..| ....      ...|.|  .|..| .||.... .      ||..|.. ||... .     .| .|||
Ywpl..ggslty..gditvtllseevlddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpd......spellldflrlvrkalasgggpvvVHC

ADGIERTGLAIALDIGMQTLSRTNSCDPIKVIDELRQDRPECISHSVQYALLYKAMLIHC
 .|. |||  ||||. .. | ... .|. ...  ||. || ..    || ..|.|.| ..
saGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtpeqyrfvyealleyl
0040438 (Phosphotyrosine protein) phosphatases II 11-282 2.8e-50 166.7 In-house 20-282 (317) alignment 
Range on Protein: 11-282
Range on HMM: 20-282/317.0
VDARFMRLDKQRPSPEQLPTWATDAALNRSLGVLPSPRTRVCVRAGDPPLNINsrgaYINANFVRGFDHEHCyYIAAMSPTATSLLQFWLMIWENKVLSI
.   |..|... ... .   .     .||.  .|| ...||..   .. |. .    ||||..| |... .  .||. .|.  ..  || |.||..| .|
lleefedllslkldtysvaelpenkdknrypdilpydhsRVkLsplggdldsd....YInAsyvdgpnlkrk.fIatqgPlpntvedFwrmvweqgvtvi

LMLSKITEQNRDQCAVYWPTepGVTVKLpNGMLATCTSKEEkHHGSILRRITLK--WGEEVRDLRHWQYVDWPEDSAVPmhgsstSPDDLMHTLRAMWVV
.|| . .| .| .|| |||.  | |..  ...  |..| || ..| .||.....   ..|.| ..|..| .||.... |      |||.| . |.|.. .
vmLteleelgrekcaqYwpl..getlty.gdftvtllseee.lagitlrtlevedlgdsesrtvthfhytgWpdhgvpp......spdllldfleavrea

----RHPFLVHCADGIERTGLAIALDIGMQTLSRTNSCDPIKVIDELRQDRPECISHSVQYALLYKAMLIHCHRRSQR
     .| |||| .|. |||  ||... .. | ... .|. ....|||. || ..    ||  ||.|.| .. |. ..
ledpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalleylkrkltl
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 32-278 5.4e-50 165.0 In-house 26-270 (274) alignment 
Range on Protein: 32-278
Range on HMM: 26-270/274.0
ATDAALNRSLGVLPSPRTRVCVRAGDPPlniNSRGAYINANFVRGFDHEHCYYIAAMSPTATSLLQFWLMIWENKVLSILMLSKITEQNRDQCAVYWPTE
.  .  ||   .|| ...||.... ..    ..   |||||...|.|.|.  |.|.  | .. . .||.||....|  |.|| |..|.|...||||.|..
fgsqtknryktilPnensrvllesesse...dedssyinanyikGydeeskayvatqGPlpntvadfWrmiyqeevqvivmltklkeaneqkCavyfPda

PGVTVKLPNGMLATCTSKEEKHHGSILRRITLKWGEEVRDLRHWQYVDWPeDSAVPMHGSSTS--PDDLMHTLRAMWVVRHPFLVHCADGIERTGLAIAL
 .. ..   | .   ..|  ....  .|...||  |. |.. |. | ||| |  .| . ..     ..  .. ..    . | .|||. || |||  || 
edyeiserygdveikvekiverndysvrklvlkylerersvkhywytdWP.dhksPddantlldlvleveesreeenaklapvvvhCsaGiGrtGcfiai

DIGMQTLSRTNSCDPIKVIDELRQDRPECISHSVQYALLYKAMLIHCHR
.|... | ...  | .|.. .||.||   .  | || |...|.  . .|
siavrqlreeivvdvlkivcnlrldrGGmvqtseqyelihralclylkr
0039614 (Phosphotyrosine protein) phosphatases II 12-279 9.2e-50 165.1 In-house 35-292 (297) alignment 
Range on Protein: 12-279
Range on HMM: 35-292/297.0
DARFMRLDKQRPSpEQLPTWATDAALNRSLGVLPSPRTRVCVRAGDpplNINSRGAYINANFVRGFDHEHCYYIAAMSPTATSLLQFWLMIWENKVLSIL
.. |..| .. |.      .     .||.  .|| ...||..   |   . .    ||||..| |.|.    .||.  |.  ..  || |.||..| .|.
llefeellslkpd.ysiallpenkdknrykdilpydhsrvklkped...gvdldsdYinAsyvdgydlltrkfIatqgPlpetvedFwrmvweqgvtviv

MLSKITEQNRdQCAVYWPTEPGvtvkLPNGMLATCTSKEEkHHGSILRRITLKWGEEVRDLRHWQYVDWPedsavpMHGSSTSPDDLMHTLRAMWV----
|| | .| .| .|| |||.| |      ...  |... |. ..| ..| .... ..|.| ..|.||..||       ||   |...|.. |....     
mLtklvelgr.kcaqywpeegg....tygdftvtllkveh.ldgytvrtlevtnngesrtvthfqytgwp......dhgvppslellleflelvrealae

--VRHPFLVHCADGIERTGLAIALDIGMQTLSRTNSCDPIKVIDELRQDRPECISHSVQYALLYKAMLIHCHRR
    .| |||| .|. |||  ||... .. | ..   |. ....|||. || ..    ||  ||.|.| .. |.
lpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydallellkrk
0036941 (Phosphotyrosine protein) phosphatases II 35-281 3.6e-49 163.0 In-house 40-282 (297) alignment 
Range on Protein: 35-281
Range on HMM: 40-282/297.0
AALNRSLGVLPSPRTRVCVraGDPPLNinsrgaYINANFVRGFDHEHCyYIAAMSPTATSLLQFWLMIWENKVLSILMLSKITEQNRDQCAVYWPTEPGV
  .||.  .|| ..|||..  .|.. .      ||||..| |.|...  .||.  |. ...  || |.||..| .|.||.. .| .| .|| |||.| | 
leknRykdilpydhtRVkl..ddegsd......YinAsyvdgydlkrk.fIatqgPlpntvedFWrmvweqnvtvIvmltelvelgrekcaqywpleege

TVKLpNGMLATCTSKEEK-HHGSILRRITLKW--GEEVRDLRHWQYVDWPedsavpMHGSSTSPDDLMHTLRAMWV------VRHPFLVHCADGIERTGL
...  ...  |..| |.. . . .|| ....   ..|.| ..|..| .||       ||  .||..|.. .....         .| |||| .|. |.| 
slty.gdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwp......dhgvpespaslldfielvrkvlkllpsggpvlVHCsaGvgRsgt

AIALDIGMQTLS---RTNSCDPIKVIDELRQDRPECISHSVQYALLYKAMLIHCHRRSQ
 ||.|. .| |    ... .|. ... .||. || ..    ||  || |.| .. .. .
fiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallellkkklt
0047943 (Phosphotyrosine protein) phosphatases II 28-274 3.8e-49 163.0 In-house 32-270 (273) alignment 
Range on Protein: 28-274
Range on HMM: 32-270/273.0
LPTWATDAALNRSLGVLPSPRTRVCVraGDPPLNinsrgaYINANFVRGFDHEHCyYIAAMSPTATSLLQFWLMIWENKVLSILMLSKITEQNRDQCAVY
   .     .||.  .||  ..||..  ||.. .      ||||..|.|.....  .||.  |.  ..  || |.||..|  | || ...| .| .|| |
vallpenkdknrykdilpydhsrvkl..gdggsd......yinAsyvdgynlkrk.fiatqgPlpntvedfwrmvweqnvrviVmLtelvelgrekcaqY

WPTEPGVTVKLPNGMLATCTSKEEkHHGSILRRITLKW--GEEVRDLRHWQYVDWPEDSAVPmhgsstSPDDLMHTLRAMWV------VRHPFLVHCADG
||.| | ...  . .  |..| |. ... ..| ..|..   .|.|  .|..| .||.... |      |...|.. .....         .| .||| .|
wpleggelsltygkftvtllseet.kddytvrtleltnlgtgesrtvthfhytgwpdhgvpp......slesllefielvrkalealpsngpvvVHCsaG

IERTGLAIALDIGMQTLSRTNSCDPIKVIDELRQDRPECISHSVQYALLYKAMLI
. |||  ||||. .. | ...  |. ...  ||. || ..    || .||.|.| 
vgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrflyealle
Y_phosphatase Protein-tyrosine phosphatase 37-273 7.3e-48 158.4 Pfam-A 4-234 (235) alignment 
Range on Protein: 37-273
Range on HMM: 4-234/235.0
LNRSLGVLPSPRTRVCVragdpplN-INSRGAYINANFVRGFDhEHCYYIAAMSPTATSLLQFWLMIWENKVLSILMLSKITEQNRDQCAVYWPTEPGVT
 ||.  .||  .||| .       .  ...  |||||.|.|.. |.  .||.  |.  .. .|| |.|..|| .| || . .|..| .|| |||.| . .
knRykdilpydktrvkl.......kgsegpsdYInAnyvkgyk.ekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeees

VKLpNGMLATCT-SKEEKHHGSILRRITLK---WGEEVRDLRHWQYVDWPeDSAVPmhgssTSPDDLMHTLRAMWVVR----HPFLVHCADGIERTGLAI
..  . .  ... ...|.... .|| ..||   . .| | .....| .|| |. ||     .||..|....|..   .    .| .||| .|..|||  .
lty.gdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWp.dhgvp.....espkslldlirkvekskeaksgpvvVhCsaGvgRtgtfv

ALDIGMQTLSRTNSCDPIKVIDELRQDRPECISHSVQYALLYKAML
|||| .. |..... |  ... |||. ||....   ||. ||||.|
aldilleqleaeeevdvlqivkelRkqRpgmvqsleqYiflykail
Y_phosphatase Protein-tyrosine phosphatase 37-273 7.3e-48 158.4 In-house 4-234 (235) alignment 
Range on Protein: 37-273
Range on HMM: 4-234/235.0
LNRSLGVLPSPRTRVCVragdpplN-INSRGAYINANFVRGFDhEHCYYIAAMSPTATSLLQFWLMIWENKVLSILMLSKITEQNRDQCAVYWPTEPGVT
 ||.  .||  .||| .       .  ...  |||||.|.|.. |.  .||.  |.  .. .|| |.|..|| .| || . .|..| .|| |||.| . .
knRykdilpydktrvkl.......kgsegpsdYInAnyvkgyk.ekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeees

VKLpNGMLATCT-SKEEKHHGSILRRITLK---WGEEVRDLRHWQYVDWPeDSAVPmhgssTSPDDLMHTLRAMWVVR----HPFLVHCADGIERTGLAI
..  . .  ... ...|.... .|| ..||   . .| | .....| .|| |. ||     .||..|....|..   .    .| .||| .|..|||  .
lty.gdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWp.dhgvp.....espkslldlirkvekskeaksgpvvVhCsaGvgRtgtfv

ALDIGMQTLSRTNSCDPIKVIDELRQDRPECISHSVQYALLYKAML
|||| .. |..... |  ... |||. ||....   ||. ||||.|
aldilleqleaeeevdvlqivkelRkqRpgmvqsleqYiflykail
subfamily_PTPRD_pd Subfamily PTPRD 15-273 1.6e-47 157.4 In-house 29-278 (564) alignment 
Range on Protein: 15-273
Range on HMM: 29-278/564.0
FMRLDKQRPSPEQLPTWATDAALNRSLGVLPSPRTRVCVRagdpPLNINSRGAYINANFVRGFDhEHCYYIAAMSPTATSLLQFWLMIWENKVLSILMLS
. ...... .. .  .  .  | ||   ...  ..||. .    ... ..   ||||.|. |.. ..  |||.  |.|...  || |.||... .| ||.
ykkieegqqftweaankpaNkaKNRyanivaYdhsRVvLs....kvegdegsDYINAsfidgyr.krkayIAtqgPlaetiedFWRmvweqnsstiVmlt

KITEQNRDQCAVYWPTEpGvTVKLpnGMLATCTSKEEKHHGSILRRITL--KWGEEVRDLRHWQYVDWPeDSAVPMHGssTSPDDLMHTLRAMWVV-RHP
|. |.....|. |||.. | | .   | |    ..||.    ..| ..|  |  .|.|  |......|| |. || ..  ||  ||... ||..   ..|
kleEkgkvkchkYWPek.g.tety..geltVtleeeeeladyeirtfklkkkkssesreVrqFhFtsWP.dhgvpesa..tslLdlirkvralnepdagP

FLVHCADGIERTGLAIALDIGMQTLSRTNSCDPIKVIDELRQDRPECISHSVQYALLYKAML
 .|||  |..|||  |..|. .. .   .  |  ... .||..|.  .    ||. ...|.|
ivVhCSaGVGRTGtfividamlerikeektvDiyqyvkalrkqRnamVqteeQYiFiheail
0045450 (Phosphotyrosine protein) phosphatases II 31-276 1.8e-46 154.7 In-house 52-304 (307) alignment 
Range on Protein: 31-276
Range on HMM: 52-304/307.0
WATDAALNRSLGVLPSPRTRVCVRAGDPPLNINSrgaYINANFV--------RGFDHeHCYYIAAMSPTATSLLQFWLMIWENKVLSILMLSKITEQNRD
.     .||.  .|| ..|||..   |. |. ..   ||||..|         |.|.    .||. .|.  ..  || |.||..|  |.||.. .| .| 
lpenkdknrykdilpydhtRVklssldgsledsd...YiNAsyvrvpllllldgydl.krkfIatqgPlpetvedFwrmlweqgvtvivmltelvelgre

QCAVYWPTEpGVTVKLPNgMLATCTSKEEkHHGSILRRITLK---WGEEVRDLRHWQYVDWPedsavpMHGSSTSPDDLMHTLRAMWV------VRHPFL
.|| |||.| | ..   | .  |..|.|. ..| ..|.....     .|.| ..|..| .||       || ..|...| . .....         .| |
kcaqywPde.geeltygn.ftvtllseeh.ldgytvrtlevtdldgtgesrtvthfhytgwp......dhgvppsfeelldfieevrkaleelpkggpvl

VHCADGIERTGLAIALDIGMQTLSRTNS---CDPIKVIDELRQDRPECISHSVQYALLYKAMLIHC
||| .|. |||  ||... .. | ...    .|. .....||. || ..    ||  ||.|.| ..
VHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyeallell
DSPc_SM00195 30-273 2e-46 153.8 In-house 22-259 (263) alignment 
Range on Protein: 30-273
Range on HMM: 22-259/263.0
TWATDAALNRSLGVLPSPRTRVCVRAGDPPlninSRGAYINANFVRGFdHEHCYYIAAMSPTATSLLQFWLMIWENKVLSILMLSKITEQNRDQCAVYWP
 .    . ||.  .||  .||| .   . .    .   |||||...|  ..   |||.  |. . . .|| |.||.||  |.||..  |... .|. |||
ekkknksknRyknilpydhtrVklkkeekk....egsdYINAnyikga.nkkkkyIatQgPlpstvedFWrmvweekvkiivmlteeeengkekcdrywp

TEPGVTVKLPnGMLATCTSKEEKHHGSILRRITLKWGE--EVRDLRHWQYVDWPEDsAVPMHgsSTSPDDLMHTLRAMWVV-RHPFLVHCADGIERTGLA
 | | . .    .  .....|.| .  ||| ..|.  .  | |.....|| .||.   || .   .|  .|.....       .| .||| .|..|||  
eesggketfg.kisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdh.gvpds..tksvlellravkkskstssgpivVhCsaGvgRtgtf

IALDIGMQTLSRTNSCDPIKVIDELRQDRPECISHSVQYALLYKAML
...|| .. |....  |  ... |||. || ... . ||. .|.|.|
vtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeail
PTPc_SM00194 30-273 2e-46 153.8 In-house 22-259 (263) alignment 
Range on Protein: 30-273
Range on HMM: 22-259/263.0
TWATDAALNRSLGVLPSPRTRVCVRAGDPPlninSRGAYINANFVRGFdHEHCYYIAAMSPTATSLLQFWLMIWENKVLSILMLSKITEQNRDQCAVYWP
 .    . ||.  .||  .||| .   . .    .   |||||...|  ..   |||.  |. . . .|| |.||.||  |.||..  |... .|. |||
ekkknksknRyknilpydhtrVklkkeekk....egsdYINAnyikga.nkkkkyIatQgPlpstvedFWrmvweekvkiivmlteeeengkekcdrywp

TEPGVTVKLPnGMLATCTSKEEKHHGSILRRITLKWGE--EVRDLRHWQYVDWPEDsAVPMHgsSTSPDDLMHTLRAMWVV-RHPFLVHCADGIERTGLA
 | | . .    .  .....|.| .  ||| ..|.  .  | |.....|| .||.   || .   .|  .|.....       .| .||| .|..|||  
eesggketfg.kisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdh.gvpds..tksvlellravkkskstssgpivVhCsaGvgRtgtf

IALDIGMQTLSRTNSCDPIKVIDELRQDRPECISHSVQYALLYKAML
...|| .. |....  |  ... |||. || ... . ||. .|.|.|
vtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeail
0043336 (Phosphotyrosine protein) phosphatases II 11-275 1.3e-45 151.4 In-house 22-276 (278) alignment 
Range on Protein: 11-275
Range on HMM: 22-276/278.0
VDARFMRLDKQRPSPEQLPTWATDAALNRSLGVLPSPRTRVCVRAGDPPLNINsrgaYINANFVRGFDHEHCyYIAAMSPTATSLLQFWLMIWENKVLSI
. . | .|... . .     .     .||.  .|| ...||..   .  |. .    ||||..| |... .  .||.  |.  ..  || |.||..| .|
lllefeellsfkldtysiallpenkdknrykdilpydhsrvklsllggdldsd....YinAsyvdgynvprk.fiatqgPlpetvedFwrmvwelgvtti

LMLSKITEQNRDQCAVYWPtepgVTVKLPNGMLATCTSKEEkHHGSILRRITLK--WGEEVRDLRHWQYVDWPedsavpMHGSSTSPDDLMHTLRAMWV-
.|| . .| .| .|| |||     ...  ...  |... |. ... ..| ....     |.|  .|..|..||       ||  .|...|.. |.|..  
vmLtelvelgrvkcaqYwp....ggsltygdftvtllkeeh.lddytvrtlevtnlgdgesrtvthyhylgwp......dhgvpeslsllldflkavrea

---VRHPFLVHCADGIERTGLAIALDIGMQTLSRTNSCDPIKVIDELRQDRPECISHSVQYALLYKAMLIH
     .| |||| .|. |||. |||.. .. | ..   |. ....|||. || ..    ||  ||.|.| .
ledsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflyealley
0040439 (Phosphotyrosine protein) phosphatases II 31-276 1.9e-43 144.2 In-house 8-246 (249) alignment 
Range on Protein: 31-276
Range on HMM: 8-246/249.0
WATDAALNRSLGVLPSPRTRVCVRAGDPplniNSRGAYINANFVRGFDHEHCyYIAAMSPTATSLLQFWLMIWENKVLSILMLSKITEQNRDQCAVYWPT
.  .  .||.  .|| ...||..   .        . ||||... |... .  .||.  |.  ..  || |.||... .|.||.. .| .| .|| |||.
lpenkdknrypdilpydhsrvklsilpg....lflsdyinAsyidgyyikrr.fiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywpl

epGVTV-KlpNGMLATCTSKEEkHHGSILRRITLK--WGEEVRDLRHWQYVDWPedsavpMHGSSTSPDDLMHTLRAMWV------VRHPFLVHCADGIE
  | ..    ...  |..| |. ... ..| ..|.     |.|  .|.||.|||       || . |..||.  ..|..         .| |||| .|. 
..ggsley..gdftvtllsvev.kddytvrtleltnlydgesrtvlhiqytdwp......dhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvg

RTGLAIALDIGMQTLSRTNSCDPIKVIDELRQDRPECISHSVQYALLYKAMLIHC
|||. ||... .. | ...  |.  ....||. || ..    ||  ||.|.| ..
RtGtfiaaylmleqlekelgvdleeavkllrsqRpgavqnpeqyrflyeallell
0045098 (Phosphotyrosine protein) phosphatases II 34-279 2.9e-43 143.6 In-house 33-275 (278) alignment 
Range on Protein: 34-279
Range on HMM: 33-275/278.0
DAALNRSLGVLPSPRTRVCvragdpplninsrgAYINANFVRGFdheHCYYIAAMSPTATSLLQFWLMIWENKVLSILMLSKITEQNRDQCAVYWPTePG
....||   .|| ...||.               ||||....|.   .  .||.  |. . . .|| |.||... .|.|| . .| .|  || |||   |
nldknRykdilpydhsrVk..............dYINAsyidgy...pkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrekcaqywpe.gg

VTVKlpnGMLATCTSKEEKHHGSILRRITLK------WGEEVRDLRHWQYVDWPeDSAVPMHGSSTSPDDLMHTLRAMWV--------------VRHPFL
. .    |..  .. .|| ..  .||....        . | | ..|..|. || |  || .  ..| ..|.  .|.                   .| |
slty...gdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwp.dhgvpslpilksflellefirealkllaslllsslllldsggpvl

VHCADGIERTGLAIALDIGMQTLsrTNSCDPIKVIDELRQDRPE-CISHSVQYALLYKAMLIHCHRR
|||  |. |||  .|... .. |   . .|. ....|||. ||  .. .  ||  ||...| . .|.
VHCsaGvgRtGtlvaaylmlell..eggvdlleavkelrsqRpglavqnleqyrflyefllelllrg
0042113 (Phosphotyrosine protein) phosphatases II 32-274 3.4e-43 143.2 In-house 7-241 (245) alignment 
Range on Protein: 32-274
Range on HMM: 7-241/245.0
ATDAALNRSLGVLPSPRTRVCVRAGDPPLNINsrgaYINANFVRGFDHEHCyYIAAMSPTATSLLQFWLMIWENKVLSILMLSKITEQNRDQCAVYWPTe
  .  .||.  .|| ..|||..   .. |  .    ||||..| |... .  .||.  |.. ..  || |.||... .|.||.. .| .| .|| |||. 
penkdknrysdilpydhtrvklspdggdldsd....yinasyvdgyritpk.fiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywpl.

pGVTVKLpNGMLATCTSKEEkHHGSILRRITLK--WGEEVRDLRHWQYVDWPedsavpMHGSSTSPDDLMHTLRAMWV-----VRHPFLVHCADGIERTG
 | ...  ...  |..| |  . . ..| ....     |.|  .|..|..||       ||  .....|   |....        .| |||| .|. |||
.geslty.gdftvtllseeh.lddytvrtlevtnlgddesrevihyhylpwp......dhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtG

LAIALDIGMQTLSRTNSCDPIKVIDELRQDRPECISHSVQYALLYKAMLI
. ||... .. | ..   .. ....|||. || ..    ||  ||.|.| 
tfiaaylmleqlekelgvsleeavkelrsqRpgavqtpsqyrflyealle
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 15-274 1.2e-41 137.9 In-house 29-281 (319) alignment 
Range on Protein: 15-274
Range on HMM: 29-281/319.0
FMRLDKQRPSPEQLPTWATDAALNRSLGVLPSPRTRVCVRAGDPplniNSRGAYINANFVRGFDHEHCyYIAAMSPTATSLLQFWLMIWENKVLSILMLS
|. |..  .   .  .   .   ||   .|.  |||| . . |          ||||.|. |.....  .||...| .. .  || |.||...  ..||.
fkllkeavndtfdsaskeenkkknryqnilaydrtrvvlseldg....vegsdyinasfidgyqerek.fiatqaPlentiedfWrmvWeeessivvmlt

KITEQNRDQCAVYWPTEPGVTvklpNGMLATCTSKEEKHHGSILRRITLKW-GEEV--RDLRHWQYVDWPEDsAVPMHGSSTSpdDLMHTLRAMWVV--R
|..|. . ..  |||.|  ..     | |     .||. .. | |...|.   .||  |.. |.|| .||.. .|| .. |    ||.. .|  .     
klveklkvklkkywpeenfee....yGrlivtleeeeeledyiirklklnkkssevetRevkhfqyteWpdh.dvPekatsll..dllkrirksrektqs

HPFLVHCADGIERTGLAIALDIGMQTLSRTNSCDPIKVIDELRQDRPECISHSVQYALLYKAMLI
 |  |||..|. |||  |.||. .. ... .  |  ... .||  |.  ...  || ..|.|.| 
gPivvhCsaGvGRtGtfivldamlervkeegvlDvfstvsrlRtqRnimvqrpeqYkfiyealle
subfamily_PTPRB_pd Subfamily PTPRB 33-281 6.9e-41 135.2 In-house 50-290 (293) alignment 
Range on Protein: 33-281
Range on HMM: 50-290/293.0
TDAALNRSLGVLPSPRTRVCVRAgdppLNINSRGAYINANFVRGFDHEHcYYIAAMSPTATSLLQFWLMIWENKVLSILMLSKITEQNRDQCAVYWPTEp
...| ||   .||   .|| . |    |. .|   |||||...|.  ..  .||.  |  ... .|| |.||.|.  |.|| .. |. . .|  |||.. 
vnraknrytnilpydhsrvkLaa....lkdesgsDYinanyipgynspr.efiatqGPlpetvddfWrmvwekkssiivmltqlvekgkvkCeeYWPad.

gvTVKLPNGMLATCTSKEEKHHGSILRRITLKWGEEVRDLRHWQYVDWPeDSAVPMHgsSTSPDDLMHTLRAMW---VVRHPFLVHCADGIERTGLAIAL
  .     | .     .||. .  ..| .... ..| |..|..... || |  || .  ...  |...|.| .      ..| .|||. |. |||  |||
..eepvlyGdikvtlvaeeeledwvirelkiekekeerkvrqyhftsWp.dhgvPek..tktlldfvrtvreaiektaskrPivvhCsaGvGRtGtfial

DIGMQTLSRTNSCDPIKVIDELRQDRPECISHSVQYALLYKAMLIHCHRRSQ
|  .|......  | . .. |||..|   .    ||  .....|  ......
drllqaieeedyvdifgivaelReeRnllvqtekqYifihqcvldllrkkee
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 12-272 1.2e-40 134.6 In-house 25-279 (305) alignment 
Range on Protein: 12-272
Range on HMM: 25-279/305.0
DARFMRLDKQrPSPEQLPTWATDAALNRSLGVLPSPRTRVCVRAGDpplnINSRGAYINANFVRGFDHEHCyYIAAMSPTATSLLQFWLMIWENKVLSIL
.|..  | .. ... .. .  ...| ||.  . . .  |. ... .     .    ||||..| |...... ||.| .|  . . .|| .|.| || .|.
eaqykslyee.eesidvgkkeankaknrlkeitlldddriilteke....slddsdyinasyvdgykrkkk.yivaqgPlkntvadfWrliveekvstiv

MLSKITEQNRDQCAVYWPTEPGVTVKLpNGMLATCTSkEEKHHGSILRRITLKW---GEEVRDLRHWQYVDWPEDSAVPMhgsSTSPDDLMHTLRAMWVV
||.|. |...|.|  |||.. . .... . .  . .| |..  . | |....      .| | . ..|  |||..  . .   .||  .|.. ..  .  
mltklveggkdkCrqYWpesktekkef.gefsvelks.ektasdyieRklkisiededkesrtvlqyqltdWPdhGvpqf...atsllslikrvqkdqkk

R--HPFLVHCADGIERTGLAIALDIGMQTLSRTNSCDPIKVIDELRQDRPECISHSVQYALLYKAM
    | |||| .|. |||  ||.|| .. | . .. |  .|. .||. |.. ..   ||  |. |.
dkgvpllVhCsagvgRtGvfiavdialerlkkEevvdvfevlkqlRskrmkmvqtldqYvflhdal
subfamily_PTPN12_pd Subfamily PTPN12 34-278 3.4e-40 132.8 In-house 40-279 (290) alignment 
Range on Protein: 34-278
Range on HMM: 40-279/290.0
DAALNRSLGVLPSPRTRVCVRAGDPplniNSRGAYINANFVRGFDHEhCYYIAAMSPTATSLLQFWLMIWENKVLSILMLSKITEQNRDQCAVYWPTEPG
. . ||   .||   .|| ..  .     .    ||||||..| . . . |||| .| .. | .|| |||| .|  ..|. .. | .. .|. ||| | .
nvkknrykDilPydksrvelskiee....eegsdYinanfikgvegk.leyiaaqgPLpktlddfWrmiweknveivvmaCrevelgkkkCerYWpeege

VTVKLpNGMLATCTSKEEKHHGSILRRITLKWGEEVRDLRHWQYVDWPeDSAVPMhgSSTSPDDLMHTLRAMWV-VRHPFLVHCADGIERTGLAIALDIG
 ...  . .  |.....  ... ..| ....  .| | .. ..| .|| |  ||   | .|  .|....| .     .|..|||. |. |||  ||.|. 
eelef.gefevtleeekavdddflirtLkveaqkesrkvyqfhYtaWP.DhgvPs..saksllelielvrelqesedaPlvvhCsaGvGrtGtiiaidyv

MQTLSRTNS---CDPIKVIDELRQDRPECISHSVQYALLYKAMLIHCHR
 . | . .     |  ... |||..|.  .    || |.|||..  ...
rellkaekipeeldvfdlvlelrkqraalvqtkeqyelvykavaelvqk
subfamily_Ptp69D_pd Subfamily Ptp69D 37-273 3.5e-39 129.7 In-house 51-283 (307) alignment 
Range on Protein: 37-273
Range on HMM: 51-283/307.0
LNRSLGVLPSPRTRVCVragdPPLNINSRGAYINANFVRGFDHEHcYYIAAMSPTATSLLQFWLMIWENKVLSILMLSKITEQNRDQCAVYWPTEpgvTV
 ||.  . .  .||| .    ...| .    ||||.|..|.....  .|||  |  . .  || ||.| .|  | |||..||.||..|| ||| |   . 
knRyedikafDktRvkL....kkingkedsdYinasfikgykekk.kfiaaqdPveatigDfWRmiaeqevtlivmlsnlteknrkkcakYWpie...de

KLPNGMLATCTsKEEKHHGSILRRITLKWGE-------EVRDLRHWQYVDWPeDSAVPMHGSSTspDDLMHTLRAM-WVVRHPFLVHCADGIERTGLAIA
.  . .| ..  .||||.  | | . .   .       . | .  ..|  |. || || .  .    .|.. .| .    | | .|||  | .|.|. .|
vqygdilvklv.seekhsdyiiReldvskkkeesgevedsrkvvqyhytgWk.DskvPevargl..lklieqvrelyklnrsPivvhCsaGvgrsgifva

LDIGMQTLSRTNSCDPIKVIDELRQDRPECISHSVQYALLYKAML
||. .| |   .. | .... .||..|.  .    ||  ||.|.|
ldsllqqlkaedkvdifetvkdLrsqRnllvqsleqYvflyrall
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 41-274 1.3e-38 127.8 In-house 48-274 (281) alignment 
Range on Protein: 41-274
Range on HMM: 48-274/281.0
LGVLPSPRTRVCVRagdpPLNINSRGAYINANFVRGFDHEHcYYIAAMSPTATSLLQFWLMIWENKVLSILMLSKITEQNRDQCAVYWPtEPGVTVKLPN
  .     ||| |     | . |.   ||||||| |.. |.  |||. .|  .|| .|| |.||.||  | |. .  |... .|  ||| ..  ..|. .
snivaYDatrvkvt....pneenkntDYinanfvpgykgek.eyiatqgPvPaslvafWqmvweqkvsaivmvtreieagklkChrYWP.ddnselkygd

GMLATctSKEEKHHGSILRRITL-KWGEEVRDLRHWQYVDWPEdsavpmHGSSTSPDDLMHTLRAM-----WVVRHPFLVHCADGIERTGLAIALDIGMQ
 .. .   .||... .| |...| . . | |.... .|. ||.      ||  ... .|..  ...         .|...||. |. |||  ||||  ..
vtvks..taeeekatyierkfkleresgetreveqlaytaWPd......hGvPattkellefrkevlkltekktkaplvihCsaGvGrtGtyialDrlvk

TLSR-TNSCDPIKVIDELRQDRPECISHSVQYALLYKAMLI
.... ... |.  |. |||..|   .   |||. .|||.| 
aveaeleeldvkavvaelrkernlmvqtvvqyefvykavld
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 38-279 3.6e-38 125.9 In-house 47-279 (515) alignment 
Range on Protein: 38-279
Range on HMM: 47-279/515.0
NRSLGVLPSPRTRVCVRAgdppLNINSRGAYINANFVRGFDHEHCyYIAAMSPTATSLLQFWLMIWENKVLSILMLSKITEQNRDQCAVYWPTEPGVTVK
||   .||  ..|| .      .| |    |.|| ....|| ... |||.  |  .|.  || ......|  | |..|  |... .|. |||  || .||
nryknilPydsvrvklev....indnPhsdyfnasyipsfdndka.yiasqgPnkasvddfWrlvlqenvttiamvtklkegdkikcgkyWPdkpgdsvk

LpnGMLATCTSKEEKHHGSILRRITLKWGEEVRDLRHWQYVDWPeDSAVPMHGSStsPDDLMHTLRAMW-VVRHPFLVHCADGIERTGLAIALDIGMQTL
.  | .   .   |   | | |..|.  |...| .  ... .|| |  || | ||     |.. ..|    . ||...||. |. |||. |..|  .   
f..GsikvelvsleactggikrkltvlkgddsrtvtqfhfteWP.dkGvpkhtss..llklikevkadhgqythpliihcsaGvGrtGvvisidsvvaha

SRTNSCDPIKVIDELRQDRPECISHSVQYALLYKAMLIHCHRR
  |.. |  ...  .||.||  .    |||..| |.| . . |
kttrmvdvfnfvtnirqkrpylvqtqeqyafiygavledllwr
subfamily_PTPN3_pd Subfamily PTPN3 33-273 3.6e-37 122.8 In-house 40-272 (280) alignment 
Range on Protein: 33-273
Range on HMM: 40-272/280.0
TDAALNRSLGVLPSPRTRVCVRagdpplniNSRGAYINANFVRgFDHEH----CYYIAAMSPTATSLLQFWLMIWENKVLSILMLSKITEQNRDQCAVYW
 ... ||   .||   ||| ..        .|.  |||||.|  .. .       |||.  | |..  .|| |.||.|.  |.||  ..|. | .|  ||
enlsknryrdilpydatrvklk........esetdyinanyvn.meipstglvnryiatqGPlaktatdfWqmvweqksslivmlttlverGrvkChqyW

PTePGVTVKLPnGMLATCTSKeEKHHGSILRRITLKWGE--EVRDLRHWQYVDWPeDSAVPMHgsSTSPDDLMHTLRAMW-VVRHPFLVHCADGIERTGL
|. .. ....  ..  .|... ....  .|| ..||  |  | | . . ||..|| |..|| .  |..  ......|..  . ..| .|||. ||.|||.
Pe.tedeleyg.efsvkceke.detksyvlrelvlkdketkeerkilqlqylaWp.dhgvPdd..sadflefvervrklrsgkeePvvvhCsaGigrtGv

AIALDIGMQTLSRTNSCDPIKVIDELRQDRPECISHSVQYALLYKAML
 |.|.. .. . ....  |.... ..|. |   .  . || .. .|.|
lilletalalieaaepvypldivrtmrdqramlvqtasqykfvCeail
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 34-279 3.6e-37 122.9 In-house 44-280 (315) alignment 
Range on Protein: 34-279
Range on HMM: 44-280/315.0
DAALNRSLGVLPSPRTRVCVRAGDpplNiNSRGAYINANFVRGFDHEHCyYIAAMSPTATSLLQFWLMIWENKVLSILMLSKITEQNRDQCAVYWPTEPG
.   ||   .||  ..|| .   |   . .    |||| .....|.... |||.  |  .|.  || |....|| .| |..|  |... .|. ||| . .
nfkknryknilPldsarvklevid...d.sPdsdyinasyiksvdddka.yiasqgPlkasvddfwrmvlqekvttivmvtkkqegdkikcrqywPdrka

VTVKLPNGMLATCtsKEEKHHGSILRRITLKWGEEVRDLRHWQYVDWPEdSAVPMHGSstSPDDLMHTLRAMW-VVRHPFLVHCADGIERTGLAIALDIG
 .|.. .  ...   . |   . . |..... .|| | .  .|. .||.   |. . |  |   |.. ..|      ...||||. |. |||. |..|  
dsvefGsikvell..sleadtdgvarklvtrkseesrtvtqfqftewPd.kGvdkqts..sllklikevkadngkkefsllvhcsaGvGrtGvvisidev

MQTLSRTNSCDPIKVIDELRQDRPECISHSVQYALLYKAMLIHCHRR
.. . ||.| |  ... .||..||  .    .||..| |.| . . |
vaqikrtrsvdvfnfvknlrakrpylvqteeeyafiydavledllwr
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 30-273 3.7e-37 123.1 In-house 42-277 (318) alignment 
Range on Protein: 30-273
Range on HMM: 42-277/318.0
TWATDAALNRSLGVLPSPRTRVCVRagdpPLNINSRGAYINANFVRGFDHEHCyYIAAMSPTATSLLQFWLMIWENKVLSILMLSKITEQNRDQCAVYWP
.  ...| ||   .|.  .||| ..    .|. .    |||||.. |. ...  |||| .| .  .  || |.|| .   |.||....|. ..... |||
lepvnkaknryanilaydhtrvkLq....mlegeegsDyinanyidGyrrkka.yiaaqaPlpetieDfWrmvWeqnsavivmltqeeergkakvhryWP

TEPGVTVklpnGMLATCTSKEEKHHGSILRRITLKWG--EEVRDLRHWQYVDWPeDSAVPMHGssTSPDDLMHTLRAMW--VVRHPFLVHCADGIERTGL
 .   .     | |    ..| .    .||.....    ||.|. | ..| .|| |. || .|  .|  ||. . ...     ..| .|||. |. ||| 
skgsrsy....gklvvelkeevelsdyvlrefkvtrteeeesrqvrqyhytsWp.degvpesg..aslldlvrqvskaqqksgagpivvhCsaGvGrtGv

AIALDIGMQTLSRTNSCDPIKVIDELRQDRPECISHSVQYALLYKAML
 ||.|| .. .   .  |  ... .||. |.  .    || ..|...|
fiavdillerikaealvDvfqtvkqlreqrnlmvqtedqyefiydvll
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 34-279 6.7e-37 122.1 In-house 47-282 (288) alignment 
Range on Protein: 34-279
Range on HMM: 47-282/288.0
DAALNRSLGVLPSPRTRVCVRAGDpplnINSRGAYINANFVRGfDHEHCYYIAAMSPTATSLLQFWLMIWENKVLSILMLSKITEQNRDQCAVYWPTEPG
.|  ||   .||   .|| .. ..     ..   ||||... | ....  |||. .| | .. .|| ...|||.  |.||... |... .|  |||..  
nakknRyrnilpyDekrvklkkle....eeagaDYinasyidg.ekkkkkyiatqgPladtvndfWelvyenktstivmltelveggktkCeeYWPdadk

VTvKlpNGMLATCTSKEEKHHGSILRRITLKWGEEVRDLRHWQYVDWPEDSaVPMhgSSTSPDDLMHTLRAMWVVR-HPFLVHCADGIERTGLAIALDIG
 . .   | .     .... .  .||.. |.  .. ... ..||  ||... ||   |..   .|....         |..|||..|. |||  ||||  
pk.n..yGsvtvtlveskeledfvlrklllekkkteleitqyqylaWpdhg.vPe..skapllellrqvkvanqadtgpiivhCsaGvGrtgtFialdal

MQTLSRTNSCDPIKVIDELRQDRPECISHSVQYALLYKAMLIHCHRR
.... ...  | . .. .||. |.  .    ||  .|...|   ...
idaveeedyiDvagtvaklRkqRallvqtlkqYefiyevllslieed
subfamily_PTPN23_pd Subfamily PTPN23 37-281 7.9e-37 121.6 In-house 46-285 (288) alignment 
Range on Protein: 37-281
Range on HMM: 46-285/288.0
LNRSLGVLPSPRTRVCVRagdpplniNSRGAYINANFVRGFDHEHCYYIAAMSPTATSLLQFWLMIWENKVLSILMLSKITEQNRDQCAVYWPTEPGVTV
 |||  .||  ..||..|        .|.  |||| ||..       .||. .| ...|  ||||..|.|.  | || . .|... ... |||.. | ||
knrsrdilPyDhnRvklr........gskDDYinAsfvkdlspgcPdfiatqaPlqstlnDFWlmvyeqkssviVmllskeelgkpkvdrYwPedkgetv

KLPNgMLATCTS-KEEKHHGSILRRITLKWGEEVRDLRHWQYVDWPEdsavpmHGSSTSPDDLMHTLRAMWV--------VRHPFLVHCADGIERTGLAI
| .. .  |. | .| ..|     ... .  ..|....| |.  |||      .|   ||..|.. | ..          .. | .|||  |..|||.  
kfgd.lsvtlksvretethvervlkletldadavksvshlqltsWpe......lGvPasPetllqfldevesayeavqrksktPlvvhCsaGvgRtgvfa

ALDIGMQTLSRTNS-CDPIKVIDELRQDRPECISHSVQYALLYKAMLIHCHRRSQ
 .   .. |.. |   | |.|.  ||..|   .... |.  .|.|.| . .|  .
lvyaavrelekgnglldiiqvvsrlreqRrfmvqekeqlkfsyeavleaarrvld
0037934 (Phosphotyrosine protein) phosphatases II 34-273 8.5e-37 122.4 In-house 10-239 (243) alignment 
Range on Protein: 34-273
Range on HMM: 10-239/243.0
DAALNRSLGVLPSPRTRVCVragdpplniNSrGAYINANFVRGFDhehcYYIAAMSPTATSLLQ----FWLMIWENKVLSILMLSKITEQNRDQCAVYWP
.   ||  ..|| ...||..         .. . |||||......    ..||   |.  .. .    || |.||... .|.|| . .| .| .|| |||
nlsknrysdilpydhsrvkl.........eg.sdyinanliyvtp....rliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywp

tePGVtvkLPNGMLATCTSKEEkHHGSILRRITLKW---GEEVRDLRHWQYVDWPEDSAVP-MHGSSTSPDDLMHTLRA-----MWVVRHPFLVHCADGI
   .|     ...  |..| |. ... ..| ..|..   ....|  .|..|. ||. .. . .       |..   ...      .   .| ||||  |.
..gev...tygdftvtllseeh.lddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGv

ERTGLAIALDIGMQTLsrtnSCDPIKVIDELRQDRPE-CISHSVQYALLYKAML
 |||. ||... .. |    ..|. .....||. ||  ..    ||  ||.|.|
gRtGtliaaylmllll....gvdleeavkllreqRpgkavqtpsqyrflyeall
subfamily_PTPRG_pd Subfamily PTPRG 38-274 4.5e-36 119.2 In-house 51-285 (563) alignment 
Range on Protein: 38-274
Range on HMM: 51-285/563.0
NRSLGVLPSPRTRVCVRAGdPplNINSRGAYINANFVRGFDHEHCyYIAAMSPTATSLLQFWLMIWENKVLSILMLSKITEQNRDQCAVYWPTEPGVTVk
|| | .... |.|| ..   |  .....  |||||.. |. ...  .||.  | .. .  || ||||..|  | |.....|..| .| ||||..  .|. 
nRylnivaydrsRvklspl.p..gkkkklDYinAnyidGyqkska.fiatqgplkdtfddFWrmiWeqnvaiivmitnlvergrrkcdvYWPkdesety.

lpnGMLATCTSKEEKHHGS-----ILRRITLKWGEE---VRDLRHWQYVDWPeDSAVPMHgssTSPdDLMHTLRAMWVVRH---PFLVHCADGIERTGLA
   | |     .||..  .     ... . || ...   ..  |...| .|| | .|| |   . | .|..  ..    ..   | .|||  |. |||  
...galqvtlieeevlalytvrtlviknlklkkkkqcdteklvrqyhytkWP.dhgvPeh...slp.vLifvkkssaankaeaGPivvHcsaGvgrtGty

IALDIGMQTLSRTNSCDPIKVIDELRQDRPECISHSVQYALLYKAMLI
|.||  .. . . |. .  ...  .|  |.  .    ||  |..|.| 
ivldtllkqiqqenavnvfgflkhiraqRnflvqteEqYiflhdalle
subfamily_PTPN13_pd Subfamily PTPN13 34-274 5.2e-36 119.3 In-house 37-267 (273) alignment 
Range on Protein: 34-274
Range on HMM: 37-267/273.0
DAALNRSLGVLPSPRTRVCVRAGDPplninsrgaYINANFVRG-FDHEHCYYIAAMSPTATSLLQFWLMIWENKVLSILMLSKITEQNRDQCAVYWPTEP
. . ||   |||  .||| . .  .         ||||....   ....  |||.  |  ..   ||.|.|| |.  | |...  |... .|  ||| . 
nkdknryrnvlPydetrvklgdegg.........yinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweqkaeviamvtlekekgkvkchrywPesk

GVTVKLPNGMLaTCTSKEEKHHGSILRRITLKW--GEEVRDLRHWQYVDWPEdsavpmHGSSTSPDDLMHTLRAMWVVRH---PFLVHCADGIERTGLAI
. ..|. | .      | .|..|  .|....|    .|.|.. | ..|.||.      ||  .|...|.. .. .  ...   | .|||. || |.|  |
nkklkvsnrle.vellkvqkldgfvvralavkdsesgesrevahlnfvkwPd......hgvPssaaellqfvaevrrlqtdagPivvhcsaGiGrsGtli

ALDIGMQTLSRTNSCDPIKVIDELRQDRPECISHSVQYALLYKAMLI
..|. .. ..| .. |  ... .||. |   .  . || . |||.| 
tidvvlglierdkefdvkeivrklreqrqgvvqtkdqyifvykaile
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 38-273 7.3e-36 118.8 In-house 55-281 (297) alignment 
Range on Protein: 38-273
Range on HMM: 55-281/297.0
NRSLGVLPSPRTRVCVRAgdppLNINSRGAYINANFVRGFDHehcYYIAAMSPTATSLLQFWLMIWENKVLSILMLSKITEQNRdQCAVYWPTEPGVTvk
.|   .||. . || ..     .| .    |.|| ||.|. |    .|.   |  ...  || |.....|  |.||..  |... .|| ||. .  .|  
sRYkniLPydssRvkLai....vnddpdsDyvnasfvkgnkh...rlittqmPmkatvadfWamvldeqvstivmlnddnerdk.kcaryWsdkgvtt..

lpNGMLATCTSKEEKHHGSILRRITLKWGE--EVRDLRHWQYVDWPEDsAVPMHGSSTSPDDLMHTLRAMWVVR--HPFLVHCADGIERTGLAIALDIGM
   | ..  ..  .. .| | | .... |.    | .. .|.|.||.. ||. . | .|  .|.. .|  .  .   | ||||  |. |||. ...|  .
..fGdvsvvllsvsereGfikrelevtkgkakarrvvkqyqfveWPdk.averkdsassllklisevrkdfsqnaegPllvhclaGvGrtgvlltidsvv

QTLSRTNSCDPIKVIDELRQDRPECISHSVQYALLYKAML
    |... |  ...  |||.||  .    ||...|.|.|
aeakrekevdifglvkklrqerpylvqtkeqykfvyvavl
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 35-273 3.8e-35 116.6 In-house 57-287 (298) alignment 
Range on Protein: 35-273
Range on HMM: 57-287/298.0
AALNRSLGVLPSPRTRVCVRAGDpplnINSRGAYINANFVRGFDHEHcYYIAAMSPTATSLLQFWLMIWENKVLSILMLSKITEQNRDQCAVYWPTEpgv
   ||   ....  .|| ... |     .  . |||| |. ......  .||.  |  ... .|| |..|... .| || ...|... ..  |||.|   
kkkNRyadiialdssRvvLeked....adeesdYiNAsflhaykgrn.afiatqaPltetvedFWrmvteedigtiVmltnleeldktkyhkywPde...

tVKLPNGMLATCTSKEEKHHGSILRRITLK--WGEEVRDLRHWQYVDWPEDsAVPMHGssTSPDDLMHTLRAMWVVRH--PFLVHCADGIERTGLAIALD
  |   |..     ..|..   | |.....    |. | .|. ... ||.  .|| .   ||  ||..  ||.       | .|.|..|..|.|  ||.|
.gketygeitvsllskeefadlivrklkvskkkeekerevrqlhftsWpdk.gvpena..tsvldllrkvrasqqqagnkpvivqCsaGvgRsGtfiaid

IGMQTLSRTNSCDPIKVIDELRQDRPECISHSVQYALLYKAML
  .. . . .. |  .|.  ||..||. .    ||. .|.|.|
svlervkkeqvvDvfqvvkvlRkkrpgavqteeqYvfiyeavl
subfamily_PTPN9_pd Subfamily PTPN9 38-276 4.2e-35 116.2 In-house 46-290 (297) alignment 
Range on Protein: 38-276
Range on HMM: 46-290/297.0
NRSLGVLPSPRTRVCVRAgdppLNINSRGAYINANFVRGFDHEHCyYIAAMSPTATSLLQFWLMIWENKVLSILMLSKITEQNRDQCAVYWPTEPGVTVK
||   ||   .||| .      .. ..   ||||||| |. .... .||.  |       ||.|.||..|| |.|  .. |. | .|. |||.| . . .
nrytdvlcydetrvvlak....vdedeasdyinanfvdGykqkka.fiatqGplkktvsdfWrmvWeqevlvivmttrvvergrlkcgqyWpleeessae

LPNGMLATCTSKEEKHHGSILRRITLKWGEEVRDLRHWQYVDWPeDSAVPMHGSSTS---------PDDLMHTLRAMW---VVRHPFLVHCADGIERTGL
  .  ...   .||...      |.    || | . |.|.. || |  ||  ..|              ....| . |   .   | .|||. || ||| 
fgdlsvsnveveeeedykvrvleiknvkteesrkvthfqflsWP.dyGvPssaaslldvlekvrekqalavkelgdewkghpsgPPivvhcsaGiGrtGt

AIALDIGMQTLSRTNSCDPIKVIDELRQDRPECISHSVQYALLYKAMLIHC
 |.||| .. | ... .| ....  ||. |   |    ||.. |.|.| . 
fitldiclsrleevgtvdvvetvkllrtqrafsiqtpeqyefcylavleya
subfamily_PTPN6_pd Subfamily PTPN6 38-280 1.2e-34 114.7 In-house 58-301 (306) alignment 
Range on Protein: 38-280
Range on HMM: 58-301/306.0
NRSLGVLPSPRTRVCVRagDPPLNINsrgAYINANFVR-GFDHEHCYYIAAMSPTATSLLQFWLMIWENKVLSILMLSKITEQNRDQCAVYWPTEpgVTV
||   .||   ||| ..  .| .  .    |||||...  .  ....|||.     | . .|| |.|...   |.|. | .|.....|| |||.|   . 
nryknilPfDhtrvilk..epsvpgs...dyinanyikkevkgsdksyiatqgclettvsdFWrmvwqensrvivmttkevErgkekCarYWPde..eek

KLpNGMLATCTSKEEKHHGSILRRITL---KWGEEVRDLRHWQYVDWPeDSAVPMHGSST--SPDDLMHTLRAMW-VVRHPFLVHCADGIERTGLAIALD
.   | .   . .|....  |||....   | ..| |....... .|| | .|| . .      .|. .  . .      | .|||..|| |||  | .|
ee.yGkisvtnvseksladYilRelsvskkkkkkeerevfqyhfksWP.dhgvpkdpgavLdfledvnrkqeeleeaeagpivvhCsaGiGRtGtfiviD

IGMQTLSRTN---SCDPIKVIDELRQDRPECISHSVQYALLYKAMLIHCHRRS
| .......     .|  |..  .|. |   .    || ..|||.  . ....
illkliekkgldadidiqklvksvreqrsglvqteqqykfvykaikkyietkk
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 34-275 1.3e-34 114.4 In-house 46-282 (290) alignment 
Range on Protein: 34-275
Range on HMM: 46-282/290.0
DAALNRSLGVLPSPRTRVCVRAGdpPLNINSRGAYINANFVRGFDHEHCyYIAAMSPTATSLLQFWLMIWENKVLSILMLSKITEQNRDQCAVYWPTEpg
.  |||.  ....   |. .|    . . .    |||| .. |. ...  |||. .|.   | .|| .||..||  |.|| .|.|.....|  |||..  
nkllnRfanivvyddnritLrpi..sghkDCtneyinAcyikgykekkq.yiatqgpvsntlvdFWkliwqekvtiivmltniieegkvkCqqYWpds..

vTVKLpNGMLATCTSKEEKHHGSILRRITLKWGEE---VRDLRHWQYVDWPEDSAVPMHgsSTSPDDLMHTLRAMW-VVRHPFLVHCADGIERTGLAIAL
  .|   |      ..||.... | |.. .|  ..    . . ..|   |...  |. .  .|.   . .  . ..   ... .||| |.. |... .|.
.dtka.ygefsikllneetlneyierklevknknsagakqsvtqyqitnwdstgkvtnp..qtillvieemyktqrkrgntsivvHCSdtvgrsavfcaa

DIGMQTLSRTNSCDPIKVIDELRQDRPECISHSVQYALLYKAMLIH
.....    .   | ..|. ..|. .|. .   .|| .... .|  
attinkcktegvidvfqvlksqRiqkpgsvqtvqqyqgifqivlty
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 58-273 1.9e-34 114.0 In-house 69-276 (315) alignment 
Range on Protein: 58-273
Range on HMM: 69-276/315.0
PPLNINSRGAYINANFVRGFDHEHcYYIAAMSPTATSLLQFWLMIWENKVLSILMLSKITEQNRDQCAVYWPTEpgvtvKLPNGMLATCTSKEEKHHGSI
| |. ..   |.||||. |.....  |||| .| ..|.  || ...|...  |.||... |... ..  ||| .     |.  | ..    .||..    
pllendphsdyvnanfidGynkkr.ryiaaqgpnvasvkdfwrlvfeedigkivmltnlvegekrkaekywpdk.....kviyGkitvtrkseevnteyt

LRRITLKWGEEVRDLRHWQYVDWPeDSAVPMhgSSTSPDDLMHTLRAMWV-VRHPFLVHCADGIERTGLAIALDIGMQTLSRTNSCDPIKVIDELRQDRP
 | ..   |...|..  ..|  || |. ||   ....  .|. | .        . .||| .|. |||  |.||  .. .   |  |  ..|  .|| | 
vrtlsvvfgdnirevvqlhytswp.dmgvpk..ytiplmnlirtvkqhhtnsvgaivvhcsaGvGrtGtfitldavldqaeaenaidvynfitgvrqnri

ECISHSVQYALLYKAML
. ..   || ..|.|.|
kmvqvaeqyqfiydall
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 63-273 1.7e-33 110.9 In-house 34-239 (250) alignment 
Range on Protein: 63-273
Range on HMM: 34-239/250.0
NSRGAYINANFVRGFDHEhCYYIAAMSPTATSLLQFWLMIWENKVLSILMLSKITEQNRDqCAVYWPTEPGVTVklpNGMLATCTSKEeKHHGSILRRIT
.    |||| |. |.| .   .||. .|  ... .|| |..|.|. .|.||....|...  .  |||.|   .     ... .  ||| ..   . |.. 
dkesdyinasflhgyder.kafiatqgPlqatiedfWrmvleeksgtivmLtnLkesekt.yhqywPvekaeky...Gdvtvsllske.efadytkrklk

LKWGEEVRD--LRHWQYVDWPeDSAVPMHGssTSPDDLMHTLRAMWVV--RHPFLVHCADGIERTGLAIALDIGMQTLSRTNSCDPIKVIDELRQDRPEC
|   ..  .  .|. ..| || | .|| .   |.  .|.. ..|        | .|.|. |. |.|  ||.|  .. | . .  |  |||  ||.|||. 
lskakkaderivrqlhfvvWP.dkgvPeva..tavLellkkvqasqqqagnaPvivqCsaGvgrsGafiaidavlerlkkekvvdvfkvikvlrkdrpha

ISHSVQYALLYKAML
.    ||  .|...|
vesleqyvfvyeiil
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 34-275 5.7e-33 109.1 In-house 47-277 (287) alignment 
Range on Protein: 34-275
Range on HMM: 47-277/287.0
DAALNRSLGVLPSPRTRVCVRagdpplniNSRGAYINANFVRGFDHEHcYYIAAMSPTATSLLQFWLMIWENKVLSILMLSKITEQNRDQCAVYWPTEPG
.  .||.  .|.    || ..        . .  |||| |. |. ...  .|.| || .  . .|| .|....|  |.||.. .|.....|  |||.|  
nkdknRltqilvpdnyrvllk........gehpdyinavfidgykekk.afiiaesPmfntarnfWkliddrnvtaivmlcqekendeevcyqyWpeeks

VTVklpnGMLATCTSKEEKHHGSILRRITLKWGE---EVRDLRHWQYVDWPEDSAVPMHGSSTSPDDLMHTLRaMWVVRHPFLVHCADGIERTGLAIALD
|..    |  .    .||...| | |.. .|  .   . . .. .|. .|..   |. . ..    . |   .     . . .|||.|.. |... .| .
vvl....GeyniellneevnagyierklevknknkagdkqqvkqyqitnWdstgkvtepqtillvieemyktq.rkrgntsivvhCsdtvGrsamfcaaa

IGMQTLSRTNSCDPIKVIDELRQDRPECISHSVQYALLYKAMLIH
....   .    | ..|... |. .|. .    ||  .....|..
ttinkckteGviDvfqvlksqriqkpgsvqtveqykfindivley
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 63-281 2.8e-32 107.3 In-house 86-297 (319) alignment 
Range on Protein: 63-281
Range on HMM: 86-297/319.0
NSRGAYINANFVRGFDHEHcYYIAAMSPTATSLLQFWLMIWENKVLSILMLSkiteqnRDQCAVYWPTEPGVTVKLPNGMLATCTSKEEkhhgSILRRIT
     |||| || |. ..   ||||  |   .|  || |||| .. .|..|.      .|.|. ||| .  .. .  .  . . .  .|     ..| | 
eefsdyinasfvtGyqrkd.kyiaaqGPldntladfWrmiweyncstivllt......kdkcsqywplkivikeerfkvkvdsveetae....yvvrdie

LKW---GEEVRDLRHWQYVDWPEdsavpmHGSSTSPDDLMHT------LRAMWVVRHPFLVHCADGIERTGLAIALDIGMQTLSRTNSCDPIKVIDELRQ
|      ...|... . .  ||.      .|   .| |||        |.     |.. .|||. |. |||  |.||. .. . . .  |  ... .|||
lsedgkekdirkitqfhflGwpd......vGvpdypsdlmrlvkkvrhltskenhranivvhcsaGvGrtGvyivldvlldrmkeekqvdvynfvrdlrq

DRPECISHSVQYALLYKAMLI-HCHRRSQ
.|.. . . ||| ..| |.|  |   .|.
qrntlvqdlvqykfiysalleehlfghsd
subfamily_PTPRA_pd Subfamily PTPRA 38-275 4e-32 106.4 In-house 62-294 (330) alignment 
Range on Protein: 38-275
Range on HMM: 62-294/330.0
NRSLGVLPSPRTRVCVragdPPLNINSRGAYINANFVRGFDhEHCYYIAAMSPTATSLLQFWLMIWENKVLSILMLSKITEQNRDQCAVYWPTEPGVTvk
|| . .||   .|| .    .... .    |||| |. |.  |  ..|||  | . ..  || |||| |  .|.||... |.....|| |||.|  ||  
nrvvnilPydfsrvil....svkeGveesdyinasfidGyk.ekdkfiaaqGPkeetvedfwrmiweqksativmltelkerkeekcaqywPdeGlvt..

lpNGMLATCTSKEEKHHGSILRRITLK------WGEEVRDLRHWQYVDWPEdSAVPMHGSSTSpdDLMHTLRAMW-VVRHPFLVHCADGIERTGLAIALD
   | .  .  .|.      .| . ..        ...| .| . .  ||.   ||...      .|.. ....  .   |  |||. |. |||  |.||
..yGnirvevedetvlvdytvrkflvqqlpdatrekksrlvrqfhftswPd.vGvPfepiGml..kllkkvkklnqqsagpivvhcsaGvGrtGtfivld

IGMQTLSRTNSCDPIKVIDELRQDRPECISHSVQYALLYKAMLIH
  .. .   .  |  ... .||. ||. .    || ..||..| .
avlervkaerkvdvfefvkrlrlqrpqmvqtdeqyefiykvlley
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 63-281 4.6e-32 106.6 In-house 50-261 (284) alignment 
Range on Protein: 63-281
Range on HMM: 50-261/284.0
NSRGAYINANFVRGFDHEHcYYIAAMSPTATSLLQFWLMIWENKVLSILMLSkiteqnRDQCAVYWPTEPGVTVKLPNGMLATCTSKEEkhhgSILRRIT
.    |||| |. |. ...  |||.  |   .|  || |||| .. .|..|.      .|.|. ||| .  .. .  .  . . .  ||     ..| | 
eefsdyinasfitGyqrkd.kyiatqGPldntladfWrmiweyncstivllt......kdkcsqywplkivikeerfkvkvdsveesee....yvvrdie

LKW---GEEVRDLRHWQYVDWPEdsavpmHGSSTSPDDLMHT------LRAMWVVRHPFLVHCADGIERTGLAIALDIGMQTLSRTNSCDPIKVIDELRQ
|      ...|..| . .  ||.      .|   .| |||        |.     |.. .|||. |. |||  |.||. .. . . .  |  ... .|||
lsedgkekdirkirqfhflgwpd......vgvpdypsdlmrlvkkvrhltskenhranivvhcsagvgrtgvyivldvlldrmkeekqvdvynfvrdlrq

DRPECISHSVQYALLYKAMLI-HCHRRSQ
.|.. . . ||| ..| |.|  |   .|.
qrntlvqdlvqykfiysalleehlfghsd
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 35-275 8.2e-32 105.1 In-house 39-276 (287) alignment 
Range on Protein: 35-275
Range on HMM: 39-276/287.0
AALNRSLGVLPSPRTRVCVRAgDPplniNSRGAYINANFVRGFDHEHCyYIAAMSPTATSLLQFWLMIWENKVLSILMLSKITEQNRDQCAVYWPtEPGV
.  ||   |||   ||| . | ..    .   .|||||.| .. ...  .||| .| |... .|| ...|... |......  |. | .|  ||| |. |
vkknryadvlPiddtrvllsa.eg....elGsdyinanyvasytddea.fiaaqgPiaatvrdfwravletrsasvitmtreveearlkcykywP.erev

TVKLPnGMLATCTSKEEKHH--G-SILRRITlKWGEEVRDLRHWQYVDWPEDSAVPM-HGSSTSPDDL---MHTLRAMWVVrHPFLVHCADGIERTGLAI
 ...  |   .  ... |.   |   || |    ..| | ..  ....||.... |   |      |    .   |    |  | .||.  || |.|. .
PmrvG.GysvvlldydikePeygvralrlid.letrearvvkqldllswPdkvlaPtavglirfvldvkqhielardasev.GPlvvhddvGiGrsGill

ALDIGMQTLSRTNSCDPIKVIDELRQDRPECISHSVQYALLYKAMLIH
|. . .. |  .   |. .|.  ||. |   .   ||. |||.|.  .
atlvlvsrledlGrvdvaavvirlreyraalvqavvqlrllyealvty
subfamily_PTPRK_pd Subfamily PTPRK 37-276 2.8e-31 103.5 In-house 46-277 (314) alignment 
Range on Protein: 37-276
Range on HMM: 46-277/314.0
LNRSLGVLPSPRTRVCVRAgdppLNINSRGAYINANFVRGFDHEhCYYIAAMSPTATSLLQFWLMIWENKVLSILMLSKITEQNRDQCAVYWPTEPGVTV
 |||  .|.  |.|| . .    .. ..   ||||... .. .    .|..  |    .  || ......  ||.||....|. | .|  ||| .  |  
knrsgdilaydrsrvflit....idgdpssdyinaalidsykrp.aafivtqgPlqetvkdfWrlvydencasivmltelvevgrvkClkyWPedtevyg

KLPNgMLATCTSKEEkhhgSILRRITL----KWGEEVRDLRHWQYVDWPEDsAVPMHGSStsPDDLMHTLRAMWVV-RHPFLVHCADGIERTGLAIALDI
..   .|  .. ..|     . |  ..    .  ||.| .|..|.. ||.   ||..  .    .|.. . ..      . .|||  |  |||  ||.||
dikv.elvetellae....lvvrifrveklargqeeirevrqfqflgWpdh.dvPvsatg..llklvrrvkksqeeeaGrivvhCsaGaGrtGtfiaidi

GMQTLSRTNSCDPIKVIDELRQDRPECISHSVQYALLYKAMLIHC
 .. . | .  |  ... .||. ..  .    || ..| ..|  |
vldmieregvvdvfnavktlrsrkvnmveteeqykfiydvileac
subfamily_PTPN14_pd Subfamily PTPN14 35-273 2.2e-30 100.7 In-house 50-293 (300) alignment 
Range on Protein: 35-273
Range on HMM: 50-293/300.0
AALNRSLGVLPSPRTRVCVRAgdpplNINSRGAYINANFVR-GFDHEHCYYIAAMSPTATSLLQFWLMIWENKVLSILMLSKITEQNRDQCAVYWPTEPG
|  ||   |||   .|| . .     . ...  ||||  ..     ..  ||.| .|  . . .|| |.||..|  |.|| ...|. ....  |.| .  
aeknrfkdvlPyednrvelsp.....tkenstgyinassikvsvggkersyivaqgPleltvqdfWqmvWeqgvqlivmlteeeedgkeksfkyfPkles

VTVKLPNGMLATCTSKEEKHHGSILRRITLKW--GEEVRDLRHWQYVDWPEDSAVPMHGSSTSPDDLMHTLRAMWV-------VRHPFLVHCADGIERTG
   ..  |     |   |. .  | . ..||.   .| |.. | ||.|||..   .   .  |  . .. .|           .. | ||||..|. |||
kkktvefgkfkvttkfsedsdsvittglklkhlpskeertvwhlqytDWpdhgvPeDvkgflsyLeevqsvrrktnseveskeskPPvlvhCsaGvGrtG

LAIALDIGMQTLSRTNSCDPIKVIDELRQDRPECISHSVQYALLYKAML
  |  |. ..||   .. |  ||.. ||. |   ..   ||  .||...
vlilsdlliatlehneeidikkvlarLreqrmllvqtlaqYkfvYkvli
0051429 (Phosphotyrosine protein) phosphatases II 67-274 7.5e-30 99.9 In-house 5-223 (272) alignment 
Range on Protein: 67-274
Range on HMM: 5-223/272.0
AYINANFVRGFdhehC------YYIAAMSPTATSLLQFWLMiWENKVLSILMLSKITEQNRDQCAVYWP--------TEPGVTVKLPNGMLATCTSKEEK
 ||||..| |.    .      .....  |.  .  .|| . .|... .|..| . .|..|..|  |||        ... ..     |.|  .. .|| 
gyiNardvggy....grvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseel

HHGSILRRITLK---WGEEVRDLRHWQYVDWPEDSAVPmHGsstsPDDLMHTLRAmwvvRHPFLVHCADGIERTGLAIALDIGMQTLSRTNSCD------
..  |||...|.     .|.| ..|..| ||| ... . .       .|.. |..     .|.||||. |. |||...||.. .. .|..  .|      
lldyilrellltlllsagearevmhlhytdwpdhgvpq.ea....llellellld....ggpvlvHCsaGkdRTGtvvallllllgvsletivddYlltn

--PIKVIDELRQDRPECISHSVQYALLYKAMLI
  . ....|||. ||  . .  ||. ||.|.| 
lyleeaveelraqrpgavqteeqylflyealle
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 43-273 9e-30 98.3 In-house 65-280 (290) alignment 
Range on Protein: 43-273
Range on HMM: 65-280/290.0
VLPSPRTRVCVRAGDPplninsrGAYINANFVRGFDhehCYYIAAMSPTATSLLQFWLMIWENKVLSILMLSKITEQNRDQCAVYWPTEPGVTVKLPNgM
|    .||| .. | .       | |. ||.|.| .     .| .  ... . ...| |. ..||  | || .. |. . .|. |.| . | .. . . .
vvcndktrvilkdGyd.......GdyvhanyvkGlk...amfiltqGalkdtvidiwrmvlqekvaaivmlceliedGkakceqyypekeGevltfGe.i

LATCTSKEEKHHGSILRRITLKWGEEV--RDLRHWQYVDWPeDSAVPMhgsstSPDDLMHTLRAMWVVRHPFLVHCADGIERTGLAIALDIGMQTLSRTN
  .|. ...|    |.. ....  ..     |.|.. . || | .|..     |   |. |||..  .  |  |||. || |||  .|...|.| |    
tvlcseeddkdaniikktlsvrdkdsGkehklkhlkikswp.dksval.....stlallrtlrilrkasGpvvvhcsaGiGrtGtfvaievglqilldGk

SCDPIKVIDELRQDRPECISHSVQYALLYKAML
. |.....  ||. | . .   .|| .| ...|
eldlldlvralrnsrlnsvqvdiqylalveill
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 35-273 3.4e-29 97.0 In-house 49-285 (325) alignment 
Range on Protein: 35-273
Range on HMM: 49-285/325.0
AALNRSLGVLPSPRTRVCVRAgdppLNINSRGAYINANFVRGFDHEHCyYIAAMSPTATSLLQFWLMI--WEnkvLSILMLSKITEQNRDQCAVYWPTEP
 | ||   |..  ..||.. .    .. ..   ||||...| .   .  ..|| .| ....  .| ..  |.    |....  . ... |.|||||| | 
kaknrfknvvaldksrvvlet....kkddpssdyinasylrddkkkdv.flaaqaPltatindlWrlvldWr...csvvvvlneldlgkdrcavywpkem

GVTVKLpNGMLATCTSKEEKhHGSILRRITLKW--GEEVRDLRHWQYVDWPeDSAVPMHGSS-----TSPDDLMHTLRAMWVVRHPFLVHCADGIERTGL
| ....  |.     . ||     . |.. .|   . | | .. .|.  |. |  |. . ..        . .  ...|      |.||||..|. ||| 
gksktf.Gglevklrtieei.sdyvhrvldvkqvkkGetrsvkqfqlqswd.dmGvqkrpatlisilqlvkavservtantkastpilvhcsaGvGrtGv

AIALDIGMQTLSRTNSCDPIKVIDELRQDRPECISHSVQYALLYKAML
 |.|   .. .    . |  ...  ||.|||. .    || |.|.|. 
fislysalakvieesrvdifgfvkklrkdrpsmvetvdqyiliyealv
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 34-273 5.2e-29 96.0 In-house 33-263 (283) alignment 
Range on Protein: 34-273
Range on HMM: 33-263/283.0
DAALNRSLGVLPSPRTRVCVRAGDPplninsrgAYINANFVR--GFDHEHCYYIAAMSPTATSLLQFWLMIWENKVLSILMLSKITEQNRDQCAVYWPTE
.   ||   ..|  . || ...  .         |||| |.     ...   ||.| ||       || |....|. .|.||.|. |..| .|. ||| .
nkrknrnqeivpadqwrvelksesr........dyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfdekitaivmltklqedlrikCsqyWPkr

PGVTvklpNGMLATCTSKEEKHHGSILRRITLKWG---EEVRDLRHWQYVDWPEDSAVPMHGSSTSpDDLMHTLRAMwVVRHPFLVHCADGIERTGLAIA
  .      | ..    ||  ..  | . ..|.     ..   | |.|..|| | .  ..  |     ... .|.     . | .|||. || ||.  ||
Gsed....yGeftvtlrkettsnsfiikelllrvnssakstlllahyqvidWleygeqaiinslvk.fnkvislqte.skkgPivvhCstgiGrtavfia

LDIGMQTLSRTNSCDPIKVIDELRQDRPECISHSVQYALLYKAML
.   .. .      |  .|.  .|..|.  .    || |.....|
asasvkdaltesvvdvfavvkimreqrmmavqtldqyklvhelvl
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 10-273 1.6e-27 91.0 In-house 16-290 (301) alignment 
Range on Protein: 10-273
Range on HMM: 16-290/301.0
RVDARFMRLDKQRPSPEQLPTWATDAALNRSLGVLPSPRTRVCVRAgDPPLNINSRgAYINANFVRGFDHEHcYYIAAMSPTATSLLQFWLMIWENKVLS
...... .|..... . .. .  ...||||   . . .  |. ..   | |.. .|  ||||... |. ...  .||| .|    | .|| .||..|. |
kfeeqykelkegedksctvglseenkalnrfknitvyddnriilkp.kpnldlcqr.eyinasyidgysekk.kfiaaqgpmkktlvdfWrliwqekpvs

ILMLSKITEQNRDQCAVYWPTEP-------GVTVKLPNGM------L--ATCTSKEEKHHGSILRRITLKWGEEVRDLRHWQYVDWPEDSAVPMH-GSST
|.|. .  |. ...|  |||.          .||.| | .      .   . . ..   .|.| |..  |   . .|.  .| .|||.|  |. .     
ivmvtnlkegtkskceqywpnseaeseefgpftvtlvneqvyPdfvirqlnvkiqdgsnngyierkfkvksdksswdvlqlqvtdWpqdGvvreprtvLq

SPDDLMHtlRAMWVVRHPFLVHCADGIERTGLAIALDIGMQTLSRTNSCDPIKVIDELRQDRPECISHSVQYALLYKAML
. || .|  |   .   | .||| |.. |.|  ....||.    .    | ..|.  .|. .|  .    ||  .|... 
viddvih..rqqkigggpvvVHCSdtVsrsGvYcsvsiglEQckaegVVdvfqvtkavrrskpgaVtTLeqytsiydvid
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 36-275 3.3e-27 89.9 In-house 47-235 (392) alignment 
Range on Protein: 36-275
Range on HMM: 47-235/392.0
ALNRSLGVLPSPRTRVCVRAGDpplnINSRGAYINANFVRGFDHEHCyYIAAMSPTATSLLQFWLMIWENKVLSILMLSKITEQNrdqcavywptepgvt
  ||   .||  ..|| .   |      .   |.|| ....|| |.. |||. .| |.|| .|| |.....| .| |..|. | .               
kknryknilpydsarvklevid....dipdsdylnasyipsfdneka.yiasqgpnaaslddfwrmvfqenvttiamvtklkegd...............

vklpngmlatctskeekhhgsilrritlkWGEEVRDLRHWQYVDWPEDsAVPMHGSSTSpdDLMHTLRAMW-VVRHPFLVHCADGIERTGLAIALDIGMQ
                              |...|    .....||..  || | ||     ... ..| .    ||...||. |. |||. |..|  . 
.............................kgddartvaqfhftewPdk.dvpkhtssll..kfikevkadfGqythpliihcsagvgrtgvvisidsvva

TLSRTNSCDPIKVIDELRQDRPECISHSVQYALLYKAMLIH
   .|   | .... ..|. ||  .    |||..| |.|  
hakktrmvdvfnfvtnirrkrpymvqtkeqyafiygavled
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 64-274 3.9e-27 89.7 In-house 78-287 (305) alignment 
Range on Protein: 64-274
Range on HMM: 78-287/305.0
SRGAYINANFVRGFDHEHCYYIAAMSPTATSLLQFWLMIWENKVLSILMLSKITEQNRDQCAVYWPTEPGVTVKLPNGMLATCTS--KEEKH-HGSILRR
|   || ||.|      .  .|.|  |   .. .|| |. .|||  |.|| |  |  . .|| |||.  |  ..| .|..    |  |  .      .  
spsdyihanyvgcpmipekrficaqgpldqtidefwwmviqnkveqivmlcktvelgklkcaqywpaaqgeklelksgivvenvsgskpmerdaeiqitl

ITLKW-GEEVRDLRHWQYVDWPEDSAVPMHGSStspDDLMHTLRAmwvVRHPFLVHCADGIERTGLAIALDIGMQTLSRTNSCDPI-KVIDELRQDRPEC
. | . |..   .|| |. .||.    | . .|    .|. ..|     . | .|||. || |||  .|..  .. ..  ..| |. ...  ||..|   
lnltysgdqkmsvrhlqwtewpdrgvppcklts...lellsairg...skvpivvhcsagigrtgtivaieyilekiaenkpcppmpelvkalrdqrafs

ISHSVQYALLYKAMLI
|   |||  ... || 
iqndvqylfihrvmln
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 15-273 1.7e-26 88.0 In-house 22-274 (307) alignment 
Range on Protein: 15-273
Range on HMM: 22-274/307.0
FMRLDKQRPSPEQLPTWATDAALNRSLGVLPSPRTRVCVRAGDpplninSRGAYINANFVrGFDHEHCYYIAAMSPTATSLLQFWLMIWENKVLSILMLS
|  | |. |   .  .. ...  ||   |    ..|. |.             || ||.. |   .   .|.|  |  ..  .|| |. ..|| |..|| 
frvlakktpegvtveafsantdknryqdvkcqdkgrivvkfdg......lasdyihanyl.giaikpkkficaqgplentqysfwamaiqekvesvimlc

KITEQNRDQCAVYWPTEPGVT---VKLPNGM-LATCTSKEEKHHGSILR--RITLKWGEEVRDLRHWQYVDWPEDSaVPMHGSSTspddlMHTLRAMWVV
|. |  . .|  ||| | | .   .. || . .|   .|.      ..    . ..|... | ..|.|. .||.   ||    ..     .  | |.   
kvielakikceqywpleegqklvfgeapntisvanlgakklapdedlinvttlkvdwaqksrtiqhlqwenwpdrg.vpqinlta.....inlleavryd

RHPFLVHCADGIERTGLAIALDIGMQTLSRTNSCDP-IKVIDELRQDRPECISHSVQYALLYKAML
. | .|||. |. |.|  .|. . .. . .   |    |...|||..|. .|   .||  |.. .|
tnpvvvhcsaGvGrsGtivaislvqdkmiaGinckdmkklveelrsqrhyaiqteaqylylhrvll
0041856 (Phosphotyrosine protein) phosphatases II 37-280 2.2e-26 88.0 In-house 4-175 (182) alignment 
Range on Protein: 37-280
Range on HMM: 4-175/182.0
LNRSLGVLPSPRTRvcvragdpplninsRGAYINANFVRGFDHEHCyYIAAMSPTATSLLQFWLMIWENKVLSILMLSkiteqnrdqCAVYWPtepgvtv
.||   .|| ...|                 |||||...|  .    .||.  |.  .. .|. |..|... .|..|.         .  |||       
knrysdilpydhsr..............dldyInanlylgslpatr.fiatqgpllstvadflrmlkelgittivnlt.........eelywp.......

klpngmlatctskeekhhgsilrritlkwGEEVRDLRHWQYVDWPEDSAVPmhgsstsPDDLMHTLRAMWVVRHPFLVHCADGIERTGLAIALDIGMQTl
                              .. |   ...|. || ... .       .|.| . .....   .| ||||  |. |||  .|... ..  
.............................ellerlgiqylylpwpDhgvpd.......ldelldfieevleeggpvlVHCsaGvgRtgtlvaaylmkkl.

srtnSCDPIKVIDELRQDRPECISHSVQYALLYKAMLIHCHRRS
    .... ......|. || .. .  || .|. |.| ..... 
....gvsleeavklvrsrRpgmvitpnqyfflqlallellllkk
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 64-273 2.4e-26 87.4 In-house 27-236 (237) alignment 
Range on Protein: 64-273
Range on HMM: 27-236/237.0
SRGAYINANFVRGFDHEHCYYIAAMSPTATSLLQFWLMIWENKVLSILMLSKITEQNRDQCAVYWPTEpgvTVKLPNGMLATCTSKEEKHHGSILRRITL
|   ||||....|||     ||||  |  .|  .|| |.|..|   |.||. . |.|. .|  |||         . |.|.    |.|.     .| ..|
sgsdyinatylkgfdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywpst...dqpaaygvltvslkkkeefsdytvrslll

KWG---EEVRDLRHWQYVDWPEdSAVPMHGSSTSPDDLMHTLRAMWVV-RHPFLVHCADGIERTGLAIALDIGMQTLSRTNSCDPIKVIDELRQDRPECI
      .||| .  .|.  ||.   || . ..          |.  |    |...||. |. |||. . .|  ..     .  |  . .  . .|||  |
skrltlkevrlihqyqftswpd.rgvpqqtaallrfrkniinrsphvsesgpwiihcsagvgrtgiflvidamlrqakekkvvdiynyvysieedrpyii

SHSVQYALLYKAML
    || ......|
qtkdqyvfihqtil
subfamily_CG7180_pd Subfamily CG7180 38-275 5.7e-26 85.8 In-house 46-289 (296) alignment 
Range on Protein: 38-275
Range on HMM: 46-289/296.0
NRSLGVLPSPRTRVCVRAgdppLNINSRGAYINANFVRGFDHEHCyYIAAMSPTATSLLQFWLMIWENKVLSILMLSKITEQNRdQCAVYWPTEPgvTVK
||   |.|   .|| ..     |. ...  |||| .| .| ...  ||    |.  .. .|| ....... .. .|.| ..... ..  ||| .     .
nrdvkvvPyDynRvvLek....ldGeeksdYinavyvdsflkkke.yivteapkketvdefWrlvydeeisavvvLtktfdfak.mypsywpnks..keq

LPNGMLATCTSKEEKHHG----SILRR------ITLKWGEEVRDLRHWQYVDWPEDSAVPMhgSSTSPDDLMHTLRAMW------VVRHPFLVHCADGIE
  . .. . ..|.  .       . ..       . .   |.| ... |.  |. .  ||.  |...  .|..  | .        .. | .|.. ||  
ygeifveiveekqyanlkirtfkltkkivalteqekqvkaetRivklfqlteWeledkvPl..stnalielrrrvrlwrekvdedpeegPvvvvssdGas

RTGLAIALDIGMQTLSRTNSCDPIKVIDELRQDRPECISHSVQYALLYKAMLIH
|.|  .|.|. .. .....  |  . .  ||..||. .    .|  .|  .| .
RsGvylaidanlelvekeeevdvFeavktlrrsRpqLvenveeYkyiYdvllea
subfamily_PTPN1_pd Subfamily PTPN1 35-273 6.9e-26 85.6 In-house 33-268 (290) alignment 
Range on Protein: 35-273
Range on HMM: 33-268/290.0
AALNRSLGVLPSPRTRVCVRAGDPplninsrgAYINANFVRgFDHEHCYYIAAMSPTATSLLQFWLMIWENKVLSILMLSKITEQNRDQCAVYWPTEPG-
 .|||   | |   .|. .. .|          ||||..|  ... .  || .  | .     ||.|.||.|  ...|| |. |... .|| |||..   
rnlnryrdvspydhsrikleradn........dyinaslve.leeakrsyiltqGPlpntvdhfWqmvWeqkskavvmlnkvvekeqikcaqywPqgeee

VTVKLPNGMLATCTSKEEKHHGSILRRITLKW--GEEVRDLRHWQYVDWPeDSAVPMhgSSTSPDDLMHTLRAMWVVR---HPFLVHCADGIERTGLAIA
 ...| .  |     .||...  ..| . |.    .| |.. |. |. || | .||   | ..  .... .|   ..     | ..||. || |.|  . 
kellledtklkvkliseerksyytvrllelenlktqetreilhfhyttwp.dfgvpe..spaaflkflfkvresGslssdvGpavihcsaGiGrsGtfcl

LDIGM---QTLSRTNSCDPIKVIDELRQDRPECISHSVQYALLYKAML
.|  .   .    ..|.|  ||. |||. |   |    |  . | |.|
vdtclvliekkddlssvdikkvllelrkyrlGliqtadqlrfsylail
subfamily_PTPRN_pd Subfamily PTPRN 33-272 7e-25 82.3 In-house 55-288 (297) alignment 
Range on Protein: 33-272
Range on HMM: 55-288/297.0
TDAALNRSLGVLPSPRTRVCVRAgdppLNINSRGAYINANFVRGFDHEHCYYIAAMSPTATSLLQFWLMIWENKVLSILMLSKITEQNRDQCAVYWPTEP
  .  |||  |||   .|| ...     . ...  |||| ..   |  .  |||. .| |... .|| |.||. |  |..|....|..  ||. ||| | 
knvkknrskavlpydhsrvklke....easaeksdyinasaildhdprapayiatqgplastvadfwqmvweqGvvvivnltrleeegvkqckrywpdeG

GVTVKLPNGMLatcTSKEEKHHGSILRRITLKW--GEEVRDLRHWQYVDWPEDSaVPMhgSSTSPDDLMHTLRAMWVVR-HPFLVHCADGIERTGLAIAL
  . .. .  |    |.    .  ..| . ||    .| | .  . .. ||| . ||   |. |  ..   .   .  |  | .||| ||  |||  |..
sevyhiyevhl...vsehiwcddylvrsfylknlqtsetrtvtqfhflswpeeg.vPa..saksllefrrkvnksyrGrscpivvhcsdGaGrtGvyili

DIGMQTLSRT-NSCDPIKVIDELRQDRPECISHSVQYALLYKAM
|. .. | .  .  | .  .. ||..||. .    |. . ..|.
dlvlnrllkGvkeidiaatlehlrdqrpglvktkdqfefaltav
0046846 (Phosphotyrosine protein) phosphatases II 67-274 3.9e-24 80.8 In-house 13-171 (176) alignment 
Range on Protein: 67-274
Range on HMM: 13-171/176.0
AYINANFVRGFdhehcYYIAAMSPTATSLLQFWLMIWENKVLSILMLSKITEQNRDQCAVYWPTEPGVTVklpngmlatctskeekhhgsilrritlkwg
 |||||.. |      ..||   |.  .| .|. |..|...  ...| . .| .| .|. ||| . .. .                              
dyinanlilgs.....rpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgi..............................

eevrdlrHWQYVDWPEDSAVPMhgssTSPDDLMHTLRAMWVVRHPFLVHCADGIERTGLAIALDigmqtLSRT-NSCDPIKVIDELRQDRP-ECISHSVQ
       ......||. .. ..    .  ..|.  .| .    .| ||||  || |||. .|..     | .. .  .. ......|. ||  .. .  |
.......qylhlpwpDhgvpdl....elllellefirealkeggpvlVHCsaGigRtgtlvaay.....llelekglsveealalvreqRplgavqtpeQ

YALLYKAMLI
|  ||...| 
yrflyefell
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 66-273 5e-24 79.5 In-house 76-276 (439) alignment 
Range on Protein: 66-273
Range on HMM: 76-276/439.0
GAYINANFVRGFdHEHCYYIAAMSPTATSLLQFWLMIWENKVLSILMLSKITEQNRdqcavYWPTEPGVTVklpnGMLATCTSKEEKHHGSILRRITL--
  |||||...|. ..   |||.  |.  .  .|| ...|.|.  |.||... |  .     |||..  |      | .|  . .. .    ..| . .  
shyinanyikGy.yddklyiatqgpkkettddfwrlviekktvtivmltnlvesyk.....ywpsdaevcy....gdiavrvdrnielpnyvirgfkvfn

--KWGEEVRDLRHWQYVDWPeDSAVPMHGSSTSpdDLMHTLRAMWVV--RHPFLVHCADGIERTGLAIALDIGMQTLSRTNSCDPIKVIDELRQDRPECI
    .|  | . ...|. || |  || . |  .  |..... .        | .|||. |. |||  ||||| .. |   |  |   ..  ||..| . .
erdttekertvlqfhyiawp.dknvpaqashvl..dflrainsandkeeygpvvvhcsagvGrtGtiialdialeqlklenkvdikgivkvlrkqrkqmv

SHSVQYALLYKAML
 . .|| ..|.|.|
qalcqyvfiynavl
subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 62-273 7.4e-24 78.9 In-house 63-266 (281) alignment 
Range on Protein: 62-273
Range on HMM: 63-266/281.0
INSrGAYINANFVRGFDHEHCyYIAAMSPTATSLLQFWLMIWENKVLSILMLSKITEQNRDQCAVYWPTEPGVTVKLPNGMLATCTSKEEKhhGSILRRI
 ||   || ||..|    ..  || .  |   .  .|| |||...  .|.|| ...| ||..|| |.| .  . ... .  ..   |  .|    .  |.
kns.tdyihanyirspflkrg.yiltqgpkketradfwrmiwqenttaivmlcqfletnrekcaeyfprnahcclqfdklsvsyedstvnk..slvttrl

TLKWGEEVRDLRHWQYVDWPeDSAVPmhGSStspDDLMHTLRAMWVVRHPFLVHCADGIERTGLAIALDIGMQTLSRTNSCDPIK-VIDELRQ-DRPECI
 | .  | | . || . .|| |  ||  .||   . ... || .     | ..||. |. |.|  .|..| .|..    .   || ..  ||   |   .
nlsyegetrlithwlwkewp.dwqvp..ess...evmlkilrkirarstppvihcsagvgrsgtlmaveialqsihshftlpdikqivshlrvtgraasv

SHSVQYALLYKAML
    || |..| .|
qtlqqymliwkvll
subfamily_CG42327_pd Subfamily CG42327 38-188 4.2e-23 76.5 In-house 32-178 (319) alignment 
Range on Protein: 38-188
Range on HMM: 32-178/319.0
NRSLGVLPSPRTRVCVRAgdppLNINSRGAYINANFVRGFDHEHCYYIAAMSPTATSLLQFWLMIWENKVLSILMLSKITEQNRDQCAVYWPTEPGVTVK
.| . |.| | ||| ..        . .  |..|..|||.|  ...||||  .   |  .|| ..||..   |. |... |.  ..|| |.||. .   .
srvinvvPlPetrvvlqr....igdddkdeyldasyvrGyddapnsyiaaqvsledsssdfwrtvweqqsrvivqltdlselGikvcaeylPtketldnt

LPN-GMLATCTSKEEKHHGSILRRITL-KWGEEVRDLRHWQYvDWPEdSAVPM
     .| |   .| |..  |   .     .|| |.| |. | .|.| . || 
slyGdilvtlkgrevkdryaistlllkrvdkeesrelthywy.kwle.aevPa
0036282 (Phosphotyrosine protein) phosphatases II 67-270 4.2e-23 77.4 In-house 3-164 (174) alignment 
Range on Protein: 67-270
Range on HMM: 3-164/174.0
AYINANFVRGFDHEHcYYIAAMSPTAtsllqFWLMIWENKVLSILMLSKITEQNRDQCAVYWPTepgvtvklpngmlatctskeekhhgsilrritlKWG
 ||||... ..     ..||   |.|     || |..|... ...|| .  | ..  |  |||.                                 .. 
dyinaspldlsyitp.rliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe.................................lre

EEVRDLRHWQYVDWPEDSAVPMHGsstsPDDLMHTLRAMWVV--RHPFLVHCADGIERTGLAIALDIGMQTLSrTNSCDPIKVIDELRQDRPECISHSVQ
 ..|   ...|. || ... ...      ....  ..        .| ||||  |. |||. .|... .. |  ..  | .... |||. || .. .  |
dlerlgiqylylpwpDhgvpdlsi....llefvkfveealsedpggpvlVHCsaGvgRtGtlvaaylmlrgll.eslvdaldlvrelRlqrpgmvqtpsQ

YALLYK
|  ||.
yrflyy
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 38-187 4.5e-23 76.5 In-house 37-180 (297) alignment 
Range on Protein: 38-187
Range on HMM: 37-180/297.0
NRSLGVLPSPRTRVCVRAGDPplninsRGAYINANFVRGFDHEH-CYYIAAMSPTATSLLQFWLMIWENKVLSILMLSKITEQNRDQCAVYWPTEPGVTV
||   .|    ||| .. . .         ||||..|   | |.  .|| |  |. ... .|| ...|. |  | |..|. |. ||.|| |||   .   
nryrdilatddtrvkllrvit......erdyinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmvaklqedGrdkcapywpsvvqerl

KLPNGMLATCTSKEEKHHGSILRRITLKWGEEVRDLRHWQYVDWPeDSAVP
| .. ..   .|  ....  ||  ..| . .| | .|| |.. || |  ||
kagdvvveflsstsdefdrviltelqliyrsesrvvrhvqflswp.dhGvp
subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 85-275 5.8e-22 73.2 In-house 63-258 (290) alignment 
Range on Protein: 85-275
Range on HMM: 63-258/290.0
IAAMSPTAT-------SLLQFWLMIWENKVLSILMLSKITEQNRD----QCAVYWPTEPGVTVKLpNGMLATCTSKEEkHHGSILRRITLKWGEEVR-DL
|.  || .         . .|| |. . || .. || . .|....    .|| | |.. |  .|. .|.   |.|||. . . . |....|...|.   .
iltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCakYvpesvgeelkf.kgltvkCkskek.eddvetRelvvkfddeeeftv

RHWQYVDWPEDSAVPmhgsstSPDDLMHTLRAMWVVRHPFLVHCADGIERTGLAIALDIGMQTLS-RTNSCDPIKVIDELRQDRPECISHSVQYALLYKA
 | ....| . .. .      ..  |.. .. .   . | .||| ||| |     |...|.| .   ..|    .|...||. | ..|..  ..|    .
tHsllkgWnklnvqe......dtktllsliqkvkasktpvivHcvdGiSrsAalaaiilgyQkiaetsgsvkledvlkalrkqralaitsalelafvdag

MLIH
... 
ivll
0049772 (Phosphotyrosine protein) phosphatases II 37-273 1.5e-21 72.9 In-house 49-277 (314) alignment 
Range on Protein: 37-273
Range on HMM: 49-277/314.0
LNRSLGVLPSPrTRVCVragdPPLNINSrGAYINANFVRGFdhehCYYIAAMSPTATSLLQF----------WLMI--WENKVLSILM------------
 ||.| .|| . .||..    | |....  .||||..|.||    . .||.  |.   .  |          | |.  ....|  | |            
knryldilpad.nrvil....pglpvsg.sdyinasyvdgf....lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivmsrdevladelsr

---------LSKITEQNrdqcavywptepgvT----------VklpngmlatctskeekhhgsilrritlKWG---EEVRDL-RHWQYVDWPEdSAVPmh
         | ......                                                     ..    | . .|  .. ....|    .|  
LdaAlgKtpllildgng..............neptaadlellk...........................eelydpelferlgikylripvpD.gsap..

gSSTSPDDLMHTLRAMwVVRHPFLVHCADGIERTG--LAIALdiGMQTLsrtnSCDPIKVIDELRQDRP-----ECISHSVQYALLYKAML
 ..   |.... ...     .|.||||..|. |||  ...|.   |  |     ... ......|. ||      .|    ||   ..|.|
.lledfdeflefieea.dkggpvlvHCkaGkgRtgtfvvaay..lmkll....gvsleealedvrlkRpinpnpgfieqleqyefileall
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 63-273 4.3e-21 70.2 In-house 32-237 (239) alignment 
Range on Protein: 63-273
Range on HMM: 32-237/239.0
NSRGAYINANFVRGFDHEHCYYIAAMSPTATSLLQFWLMIWENKVLSILMLSKITEQNRDQCAVYWPTepgVTVKLPNgmLATCTSKEEKHHGSILRRIT
. .  ||||...| .|     |||.    ..|  .|| |.|...   |.||. . |  . .|  |||     | |  |  |     | |     |.| . 
dphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpd...stskycn..lrvtlrktevfadyiirtfv

LKWG--EEVRDLRHWQYVDWPeDSAVPMHGSSTSPDDLMHTLRAMWVVRhPFLVHCADGIERTGLAIALDIGMQTLSRTNSCDPIKVIDELRQDRPECIS
.      | | . ....  || |  || . ..        |  ..   | |...||. |. |||  . .|  ..   . .. | .. .  .|.|||  . 
msqvgqteeryvyqyhftvwp.dkgvpqyatavlglrrkitkdslpgar.pwvihcsagvgrtgaflvidamlrqakkqktvdifnyvkairedrphmvq

HSVQYALLYKAML
 | || ... |.|
tseqyvfihlavl
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 63-273 4.9e-21 70.0 In-house 33-238 (239) alignment 
Range on Protein: 63-273
Range on HMM: 33-238/239.0
NSRGAYINANFVRGFDHEHCYYIAAMSPTATSLLQFWLMIWENKVLSILMLSKITEQNRDQCAVYWPTepgVTVKLPNgmLATCTSKEEKHHGSILRRIT
. .  ||||...| .|     |||.    ..|  .|| |.|...   |.||. . |  . .|  |||     | |  |  |     | |     |.| . 
dphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpd...stskycn..lrvtlrktevfadyiirtfv

LKWG--EEVRDLRHWQYVDWPeDSAVPMHGSSTSPDDLMHTLRAMWVVRhPFLVHCADGIERTGLAIALDIGMQTLSRTNSCDPIKVIDELRQDRPECIS
.      | | . ....  || |  || . ..        |  ..   | |...||. |. |||  . .|  ..   . .. | .. .  .|.|||  . 
msqvgqteeryvyqyhftvwp.dkgvpqyatavlglrrkitkdslpgar.pwvihcsagvgrtgaflvidamlrqakkqktvdifnyvkairedrphmvq

HSVQYALLYKAML
 | || ... |.|
tseqyvfihlavl
0051082 (Phosphotyrosine protein) phosphatases II 68-272 5.6e-21 70.1 In-house 5-149 (151) alignment 
Range on Protein: 68-272
Range on HMM: 5-149/151.0
YINANFVRGFdhehcyYIAAMSPTAtsllQFWLMIWENKVLSILMLSKITEQNrdQCAVYWPTEPgvtvklpngmlatctskeekhhgsilrritlkwge
|||...| |.      ...   |.|    .|. ...|... .|..| . .| .   |. |.| .                                    
yinfsyvtgg......lyrsggpla....dflellkelgiktivnlrseeerg..ycpeylpelg...................................

evRDLRHWQYVDWPEDSavpmhgSSTSPDDLMHTLRAMWVV-RHPFLVHCADGIERTGLAIALDIGMQTlsrtnsCDPIKVIDELRQDRPECISHSVQYA
  ....|....|||. .       ..|.| ... |...     .|.||||  |. |||. .||.. ..       ... ....|.|. || .. .. |. 
..ievlhipildwpdpg......lplsfdavleflellldkkngpvlvHCsaGkgRTGtlvalylmllg......vsleealeeyrlkrpgvvqpnqqfl

LLYKAM
....|.
fqlfal
0044763 (Phosphotyrosine protein) phosphatases II 61-277 7.4e-21 70.0 In-house 13-172 (178) alignment 
Range on Protein: 61-277
Range on HMM: 13-172/178.0
NINSRGAYINANFVRGFdhehcYYIAAMSPtatslLQFWLMIWENKVLSILMLSKITEQNRDQCAVYWPTEPGvtvklpngmlatctskeekhhgsilrr
    |. ||||... ..     .|...  |      ... ...|... .|..|.. .| .. .|  |||.| |                           
eglersdyinaseilpg.....lylgslpp.....addlellkelgithivnlteelelgflkcdpywpeeag...........................

itlkwgeevrdlRHWQYVDWPEDSAVPmhgsstSPDDLMHTLRAMW----VVRHPFLVHCADGIERTGLAIALDIGMQTlsrtnSCDPIKVIDELRQDRP
             ..... .| ... .      ... .. .....        .| ||||  |. |.|. .|... ..      .... ..|...|. ||
............iqylhipipDhgvpd......llehflefvefieealdekggpvlVHCsaGvgRsgtlvaaylmkkl.....glsleeaielvrerRp

eCISHSVQYALLYKAMLIHCH
 .. .  |.  ||.  |... 
.ivpnpgqlrqLyefelrllk
0049260 (Phosphotyrosine protein) phosphatases II 81-270 9.4e-21 69.5 In-house 8-144 (152) alignment 
Range on Protein: 81-270
Range on HMM: 8-144/152.0
HCYYIAAMSPTATSLLQFWLMIWENKVLSILMLSKITEQNRDQCAVYWptepgvtvklpngmlatctskeekhhgsilrritlkwgeevrdlrHWQYVDW
. ..||.  |.  .| .|| |..|...  |.|| . .| ....|. |.                                             ..... |
pfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi.............................................qylhlpw

PEDSAVPMHGSSTSPDDLMHTLraMWVVRHPFLVHCADGIERTGLAIALDIGMqtlsrtNSCDPIKVIDELRQDRPECISHSVQYALLYK
| ... ...       .... |       .| ||||  |. |||. .|... .      . ... .... .|. ||  . .  |. .||.
pDhgvpdlsqlllflllfiekl..aldkggpvlVHCsaGvgRtgtlvaaylml......lgvsleeavalvrekRpgavpnpgqlrflye
subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 63-272 1.8e-20 68.0 In-house 56-266 (285) alignment 
Range on Protein: 63-272
Range on HMM: 56-266/285.0
NSRGAYINANFVRGFDHEHCYYIAAMSPTATSLLQFWLMIWENKVLSILMLSKITEQNRDQCAVYWPTEPGVTVKLPNGMLATCTSKEEKHHGSILRRIT
|    || |...|   ...  ||..  |   .| .|| ||...|.  .|||  . |   ..||.|.| . |  ||. .  ..    |||   |.||  .|
nhdrdyihaswmrmpgkdqstyittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekcalyypeklgevvkfgkyeitlteckeeaiagtilnalt

LKWGEEVR----DLRHWQYVDWPEDsAVPMHGssTSPDDLMHTLRAMWVVRHPFLVHCADGIERTGLAIALDIGMQTLSRTNSCDPIKVIDELRQDRPEC
.   |.       . | |   ||..   |         .| . .. .    .|  |||. |. ||   . .|     .      . . .. |.|  | ..
vintedasseplymnhvqvpwwpdq.lapeda..rpmielykwvkkvnpkekpicvhcsagvgrtatfvgidyatirimenpniemldivremramrfqa

ISHSVQYALLYKAM
.   .|. .||  .
vqshmqflflyvvl
0043147 (Phosphotyrosine protein) phosphatases II 66-269 8.4e-20 66.6 In-house 5-154 (172) alignment 
Range on Protein: 66-269
Range on HMM: 5-154/172.0
GAYINANFVRGFDhEHCYYIAAMSPTATSLLQFWLMIWENKVLSILMLSKIteqnrdqcavywptepgvtvklpngmlatctskeekhhgsilrriTLKW
  ||||... .     . .||   |.   | .|| |..|...  |..| .                                              .. .
sdyinasyldlyy.ipdrfiatqgplrntladfwrmlkelgithivnltel.............................................lydp

GEEVRDLRHWQYVDWPEDSAVpmhgSSTSPDDLMHTLRA--MWVVRHPFLVHCADGIERTGLAIALDIGMqtlsrtNSCDPIKVIDELRQDRPECISHSV
  ..|   ...|. ||  ..     ..   ..... ..        .| ||||  |. |||. .|... .       .... ......|. || .. .  
ellerlgiqylylpwpDhgvp....llellleflefidellalspggpvlVHCsaGvgRtgtlvaaylml......lglsleeavalvrekRpgavqnps

QYALLY
|| .||
qyrfly
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 67-279 6.1e-19 62.9 In-house 74-290 (305) alignment 
Range on Protein: 67-279
Range on HMM: 74-290/305.0
AYINANFVRGFDHEHcYYIAAMSPTATSLLQFWLMIWENKVLSILMLSKITEQNRDQCAVYWPTEPGVTVKLPNGM-------LATCTSKEEKHHGSILR
 || ||.|      .  .| . .|   .  .|| | ...|| .|.|| .. |.   .|. |.... . .... ..         .. | | .|.  . ..
eyihanyvstptnpk.rfictqaplektcadfwymclqdkveaifmlcnllekgakkcleyfaskdkdvlefeekgqkisvkfessvtlkfrkdakakvt

RITL---KWGEEVRDLRHWQYVDWPeDSAVPMHGSStspddLMHTLRAMWVVRHPFLVHCADGIERTGLAIALDIGMQTLSRTNSC-DPIKVIDELRQDR
.  |     ||..|   |. ..||| |  ||    .     ..  |    . . |  |||. || |||  . |.  .. |   .   |  |..  .|..|
etvlviegpgekarkvthyhwidwp.drgvpaadla.....ilellekarpskgpivvhcsagigrtgsvvmleyildqllagqiiedtdkilqkireqr

PECISHSVQYALLYKAMLIHCHRR
 . |    || .... .| .....
nnsiqtdaqylfvhqvilnyfrkk
subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 65-264 2.1e-18 61.1 In-house 74-269 (301) alignment 
Range on Protein: 65-264
Range on HMM: 74-269/301.0
RGAYINANFVRGFDHEHCyYIAAMSPTATSLLQFWLMIWENKVLSILMLSKITEQNRDQCAVYWPTEPGVTVKLPNGMLATCTSKEEKHHGSILRRITLK
. . | ||..    | |  .||. .|   .   || |.   .|  | ||..  |.. ..|. | |.... ....   .. . ...   ..  . |.. ..
krvPihanwiptsGhphr.fiatqgPlkntsedfwamlvqydvekivmlgqkvekleekceeylpvkisekldigrfkikiknkelilnkkiskrtleve

WGE---EVRDLRHWQYVDWPEDsAVPMHGssTSPDDLMHTLRAmwvVRHPFLVHCADGIERTGLAialdIGMQTLSRTNSCDP----IKVIDELRQDRPE
      . | . |.||..|..   ||     .   |||. ..     ..| .|||..|| |.       || . |.|    ||     . . .||..| .
dstgkfatrtvthyqysewtdr.gvPksh..aelfdlmelvkk...sekPivvhcsaGiGrsvaf....igteylareveadptieltealkhlrehrwn

CISHSVQ
 . .  |
gvqtnsq
subfamily_egg_pd Subfamily egg 66-274 3.1e-18 60.5 In-house 68-268 (307) alignment 
Range on Protein: 66-274
Range on HMM: 68-268/307.0
GAYINANFVRGFDHeHCYYIAAMSPTATSLLQFWLMIWENKVLSILMLSKITEQnrDQCAVYWPTEPGVTVKL-PNGMLATCTSKEEKHhGSILRRITLK
. .| || |.|       .| | .|   .  .|| |.....|  |.||.   |   ..|  |||  .  .... | ..  ..   ..|    ..|   ||
ddfihanrvkGkpl.lnefilaqaplkntvddfwrmvfqeevqyivmltsrkes..erceyywpkaesdslvtvpGslrienlkvdska.dplfrvtklk

W---GEEVRDLRHWQYvDWPEDSAVpmHgsstSPddlMHTLRAMWVVRHPFLVHCADGIERTGLAIALDIGMQTLSRTNSC-DP-IKVIDELRQDRPECI
     .| | | |||. |. . | |  .    ||   .. || .  . .| .|.. .|. ...  .|..| . .| |      .  . .  ||. |.  .
lvGgddeerflehwqg.dvnnssdv..y....sp...lrvlrklrnlskpvvvqdilGvskaatlvaieiallsllrGpitkslvlravvflrlrrrlsv

SHSVQYALLYKAMLI
.  ..| ..|. .|.
esvllylfvyrlvlf
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 68-273 4.8e-18 60.2 In-house 69-268 (288) alignment 
Range on Protein: 68-273
Range on HMM: 69-268/288.0
YINANFVRGFDHeHCYYIAAMSPTATSLLQFWLMIWENKVLSILMLSKITEQNRDQCAVYWPTEPGVTVKLPNGmlatCTSKEEKHhGSILRRI---TL-
||.|| |    . .   | | .|  . . ..| |. |. |  |.||... |. ... |.|.|.. | ....       ||   .|.   | . .   .| 
yiaanvvssaky.krrlicaqaPlngtieelWkmllesdveyivmlcellekGkeksaeyfPsklGekarigrl....ctvvkkkr.adidklvkvsllr

--KWGEEVRDLRHWQYVDWPEDsAVPMhgSSTSPddlMHTLRAMWVVRHPFLVHCADGIERTGLAIALDIGMQTLSRTNSCDPIKVIDELRQDRPECISH
  | |||   ...  . .|..| .||   .  ||   .. |  .  ...| .||.  |. |||  |   | ...|  ..     ... .||..| ..|  
iskegeekvivkilhlleWddd.gvPe..nylsp...lrllevlkslqkPivvhssaGvGrtgtlililialeslrlddflgirsllaklreerfkaiqt

SVQYALLYKAML
  ||  ... .|
emqylyvhrcvl
subfamily_ptpA1_pd Subfamily ptpA1 36-237 7.1e-18 59.5 In-house 49-257 (418) alignment 
Range on Protein: 36-237
Range on HMM: 49-257/418.0
ALNRSLGVLPSPRTRVCVRAgdppLNINSRGAYINANFVRGFDHEhcYYIAAMSPTATSLLQFWLMIWENKVLSILMLSKITEQNRDQCAVYWPTEPGVT
. ||   .||  .||| ..     .. .    |||||.. |   .   .|..  |   .. .|| |.|||..  |.|||. .|. | .|  ||| . |  
sknrytnilpvnhtrvqlkk....iqdkegsdyinanyidgaypk..qfictqgplpntiadfwrmvwenrcriivmlsresencrikcdrywpeqigge

V--KLPNG--MLATCTS-----KEEKHHGSILRRITLKWGEEVRDLRHWQYVDWPeDSAVPMHGSSTspDDLMHTL--RAMWVV-----RHPFLVHCADG
      ||  .. | .       ..  .  | | | | .  | ||. ..||  || |  .| |       .|.|..  |   ..       | .|||. |
qfsiygngnevfgtysvelveviqdpereiitrnirltfegetrditqyqyegwp.dhnipdhtqpf..rqllhsitnrqnqiipssdrnvpiivhcsag

IERTGLAIALDIGMQTLS
. |||   .  | |. | 
vgrtgtfctavimmkkld
PTPc_DSPc_SM00012 172-273 1e-17 59.6 In-house 2-104 (105) alignment 
Range on Protein: 172-273
Range on HMM: 2-104/105.0
LRHWQYVDWPEDsAVPMHGsstspDDLMHTLRAMWVVRH------PFLVHCADGIERTGLAIALDIGMQTLSRT-NSCDPIKVIDELRQDRPECISHSVQ
..| .| .||.   || ..     |.....|||.  ...      | .||| .|. |||  .|||| .| |... .. |  ... |||. || ...   |
vkhyhytgwpdh.gvPees.....dsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeq

YALLYKAML
|  ||.|.|
ylflyrall
subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 83-270 3.3e-16 54.1 In-house 6-198 (199) alignment 
Range on Protein: 83-270
Range on HMM: 6-198/199.0
YYIAAMSPTATSLLQFWLMIWENKVLSILMLSKITEQNRDQCAVYWPTEPGVTVKLPNGMLAT--CTSKEEKHHGSILRRITLKWGEEVRDLRHWQYVDW
 |||.  |   .. .|| |.||     |.|.     ..  . ..||||    | |  .  ..|   |.| .    ...           |.. |.|.  |
ryiatqhplretmadfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqftsw

PEDSAVP---MHGSSTSPDDLMHTLRAmwVVRHPFLVHCADGIERTGLAIALDIGMQT--LSRTNSCDPIKVIDELRQDRPECISHSVQYALLYK
 | ..     . |   .  .. .          | .|||.||   ||. .|||||...   |.|   | ..|   ||| |   ||   .| ..|.
kekttpnvalfvgfvvasrevskkyeq..ekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiyq
subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 83-270 3.7e-16 53.9 In-house 5-197 (198) alignment 
Range on Protein: 83-270
Range on HMM: 5-197/198.0
YYIAAMSPTATSLLQFWLMIWENKVLSILMLSKITEQNRDQCAVYWPTEPGVTVKLPNGMLAT--CTSKEEKHHGSILRRITLKWGEEVRDLRHWQYVDW
 |||.  |   .| .|| |.||     |.|.     ..  . ..||||    | |  .  ..|   |.| .    ...           |.. |.|.  |
ryiatqhplretladfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqftsw

PEDSAVP---MHGSSTSPDDLMHTLRAmwVVRHPFLVHCADGIERTGLAIALDIGMQT--LSRTNSCDPIKVIDELRQDRPECISHSVQYALLYK
 | ..     . |   .  .. .          | .|||.||   ||. .|||||...   |.|   | ..|   ||| |   ||   .| ..|.
kekttpnvalfvgfvvasrevskkyeq..ekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiyq
subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 94-269 6.9e-16 53.1 In-house 40-214 (255) alignment 
Range on Protein: 94-269
Range on HMM: 40-214/255.0
SLLQFWLMIWENKVLSILMLSKITEQNRDQCAVYWPTEPGVTVKLPNgmLATCTSKeeKHHGSILR--RITLKWG--EEVRDLRHWQYVDWPEDSAvPmh
.. .|. .|  .|   . ||.  .|.....|  |.|.|     || .  .. .|.|       .||  .||.. |   . ....|..|  |.|  | |  
tvdkfyqtivqtktevvvmlcdfaeegvekcssyfplekdeklklad..vnvtttk..ssadvvlrtleitstlgekkkthtvkhysykGWiekna.P..

gssTSPDDLMHTLRAMWVVrHPFLVHCADGIERTGLAIALDIGMQ------TLSRTNSCDPIKVIDELRQDRPECISHSVQYALLY
     . .... |...    .. .|||. || |.   .  ..  |        . |   | .....|||. |.  |   .| |.  
...elareilnilkvvrds.ksvvvhCstGiGrsaafvlaelvyqkmirsldttetveldylslleelrskrkraihtPlqlafsi
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 35-149 1.5e-14 48.5 In-house 48-173 (350) alignment 
Range on Protein: 35-149
Range on HMM: 48-173/350.0
AALNRSLGVLPSPRTRVCVR-AGDPPLNIN---SRGAYINANFVRG----FDHEHCY-YIAAMSPTATSLLQFWLMIWENKVLSILMLSKITEQNRDQCA
 | ||   .||  ..|| .. .  ..  ..   |   |||||...      . .  . |||. .|.   . .|. .| .|||  ||.|..  |.|...| 
faknrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvkvilsltsdvelnlekcy

VYWPTE--PGVTVKLPNGMLATCTSK
 ||.     ..|||| .    ..  .
rYWqegsydditvklaskwenimgin
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 39-275 2.8e-14 47.7 In-house 38-258 (267) alignment 
Range on Protein: 39-275
Range on HMM: 38-258/267.0
RSLGVLPSPRTRVCVRAGDPPlninsrgaYINANFVRGFDHEHCYYIAAmSPTATSLLQFWLMIWENKVLSILMLSKITEQNrdqCAVYWPTEPGVTVKL
|   .||   ||| .|  .          |||| .| |.  .. . .    |   .  .|. .| ..||  | .| |. ..|      .|| . | . | 
rlddnlpyddtrvilrtkeee........yinasyvegyktknafivtq.dplkntitdfltvihdqkvpvivlltkvftdn...irlfwPPkmgqakky

PNGMLATCTSKEEKHHGSILRRITLKwGEEVRDLRHWQYVDWPEDSAVPMHgssTSPDDLMHTLRAMWVVRHPFLVHCADGIERTGLAIALDIGMQTLSR
 .  .  .  |||. .  |   . .|  |  ...  . |  |  ..    .     |   . .   .    .|..|.|.||. |.|  . .|  .. . .
qdltvehslekeendyqiitlelkfk.nesahnvtlyyykkwnintnnkpy...lkplfgilaknqlengnrPlvvacsdGvGrsGtflvidsqlerakt

TNSCDPIKVIDELRQDRPECISHSVQYALLYKAMLIH
 .  |  . . ..|. |.  .    .|  ... .  .
egvsdifdflrkirsqriglvdtkeryiyihellaey
subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 88-264 3.1e-13 43.8 In-house 97-276 (302) alignment 
Range on Protein: 88-264
Range on HMM: 97-276/302.0
MSPTATSLLQFWLMIWENKVLSILMLSKITEQNRDQCAVYWPTEPGVTVKLPNGMLATCTSKEEKHHGSILRRI---TLKWGEEVRDLRHWQYVDWPEDS
. |   .| ..| .| . .|  .  |... |..  .|| |. .. | ..|. .  . |   |.. .. .  . .   |... .| .  .. . ||    |
ivpkkstlekhwalieqynvaivvqlcsfvedeekkcaeyysdkvggelkfgrytvktvsvktdleeftdkksfklytveiknekkkkkvkktvdilafs

AVPMHGSSTSPDDLMHTLRAMWVVRHPFLVHCADGIERTGLAIALDIGMQTLSRTNSCDPIKVIDELRQDRPECISHSVQ
| | ||.   ..  .. |.     ..  ||||. |. |||  .|.  |.|  |. . .| ..... .|| |   . .  |
awpdhGapkeaytaldilkfcesykknvlvhcsaGvGrtGtlvaikyGiqlcskkkvtdllsivlpvrqcryGavqdeqq
subfamily_hpo-7_pd Subfamily hpo-7 97-268 3.2e-13 44.2 In-house 49-219 (263) alignment 
Range on Protein: 97-268
Range on HMM: 49-219/263.0
QFWLMIWENKVLSILMLSKITEQNRDQCAVYWPTEPGVTVKLPNGMLATCTSKEekhhGSILR--RITLKWG--EEVRDLRHWQYVDWPEDSAVpmhgss
.|. .|  .|   . ||.  .|.....|  |.|.|     || |  ..|  ...      .|.   ..   |   ......|..|. |.|  ..      
kfyqtivqtktevvvmLcDfneegvekcssyfPlekdekqklanvnvcttkvqs....dvllktlellstlgeKkkthtvkhysykgWiekndp......

TSPDDLMHTLRAMWVVrHPFLVHCADGIERTGLAIALDIGMQ------TLSRTNSCDPIKVIDELRQDRPECISHSVQYALL
. . . .. |..     ..  |||. || |.      ..  |        . |   | .....|||. |.  |   .| |  
elareilnilkvarns.kslvvhcstGiGrsaafsvaElvyqkmirsldttstveldylsLleelrssrkraihtPmqLafs
0048076 (Phosphotyrosine protein) phosphatases II 160-273 7.4e-13 43.9 In-house 35-140 (145) alignment 
Range on Protein: 160-273
Range on HMM: 35-140/145.0
RITLKWGEEVRDLRHWQYVDWPEdsavpmHGSSTSPDDLMHTLRAMWVV---RHPFLVHCADGIERTGLAIALDIGMQtlsrtNSCDPIKVIDELRQDRP
..|     ..|   ...|..||       ||  .....|.. |...  .    .| ||||  |. |||. .|... ..     ..... ......|. ||
nltselellerlgiqylylpwpD......hgvpdllellleflefieealkeggpvlVHCsaGvgRtgtlvaaylmll.....lgvsleealelvrsqrp

ECISHSVQYALLYKAML
 .. .  |.  ||.. |
gavpnpgqlrflyefel
subfamily_CG42327_pd Subfamily CG42327 210-273 9.2e-13 42.5 In-house 248-312 (319) alignment 
Range on Protein: 210-273
Range on HMM: 248-312/319.0
HPFLVHCADGIERTGLAIALDIGMQTLSRT-NSCDPIKVIDELRQDRPECISHSVQYALLYKAML
 |  |||.||. |||| || || ...|  . .| |  ...  .|.|| . .    ||...|| . 
GPlvvhcsdGvGrtGlviasdiairsleeskrsvdiPqlvssvrrdrasavltkeqyefiykvls
subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 67-273 3.2e-12 40.8 In-house 68-273 (312) alignment 
Range on Protein: 67-273
Range on HMM: 68-273/312.0
AYINANFVRGFDHEHcYYIAAMSPTATSLLQFWLMIWENKVLSILMLSKITEQNRDQCAVYWPTEPGVtVKLPNGMLAT--CTSKE--EKHHG----SIL
 || ||||.   .    .... .|   .  .|| .       ||..|. . |.  ..|| |     |  |.| .  . |  ||  |   | .      .|
fyihanfvkictkpe.rfvctqgplentcthfwqlalslgstsiillcgfvedgsekcakyisdivgf.vdledhrvyteycteieiggkskdkithrvl

RRITLKWGEEvRDLRHWQYVDWPEdsavpmHGSSTSPDDLMHTLRAMWVVRHPFLVHCADGIERTGLAIALDIGMQTLSRTNSCDPIKVIDELRQDRPEC
. .    |.|   | |.|.  ||.      ||   | |  .  | |.   ..| . ||. |. |||  . ..  . .|      .  ..   ||.||   
kvvvkatgqe.sklnhyqwaswpd......hgmpdscdtalrllsavkkdkkpviahcsagvgrtgtlaliesmiaalrhprkqnvkdsfvllrkdrars

ISHSVQYALLYKAML
.    ||    ...|
vrvfpqyvyalrcvl
subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 63-135 9.8e-12 39.0 In-house 76-146 (310) alignment 
Range on Protein: 63-135
Range on HMM: 76-146/310.0
NSRGAYINANFVRGfDHEHCYYIAAMSPTATSLLQFWLMIWENKVLSILMLSKITEQNRDQCAVYWPTEpGVT
   . || ||.|.  ..    .| .  |   ....|| ||....  |||.| |..|. | .|  |||.  |||
sryedyihanyvkt.nylrstficsqgplqhtiidfwrmifqeraesilllckvgeegrpkcvgywpsl.gvt
SH2 SH2 domain 293-377 1.9e-11 34.5 Pfam-A 1-75 (77) alignment 
Range on Protein: 293-377
Range on HMM: 1-75/77.0
WFHGELERADAEAVIKLyceeegRQIPGAFLIRQSGPDTHSFVLSFLGDDkgHMMHHRITYDEAAdcFYLDSSGARFDLIHTLVD
|.||...|..||  ..       .. .|.||.|.|     ...||.. |.  .. | ||  .|     |  . ...|. .. ||.
WyhgkisreeaerlLle......gkkdGtFLvReSeskpGdytlsvvddg..kvkhyriqsleng..kyyitenekfsslqeLve
PH_3 PH domain 457-538 2e-11 32.5 Pfam-A 27-96 (104) alignment 
Range on Protein: 457-538
Range on HMM: 27-96/104.0
WRRRWFILQDT-ILKYFSRPSAsTANGYINLTHDTNVRVHSDKEFTIETPKRIFHLHCsdnqvqllmnqtCPQSLNQWVSIIN
 |.|...| ..  | |.   .  .  | |.|... .|.| ..|.| | ||||...|                . ...||  |.
arkRqllltegPrLiyvDpekm.elkGeIplskelkvevknskkFfihtpkrtyyled............pesnaakWvkaie
0048179 (Phosphotyrosine protein) phosphatases II 169-270 2.5e-11 39.0 In-house 46-139 (144) alignment 
Range on Protein: 169-270
Range on HMM: 46-139/144.0
VRDLRHWQYVDWPEDsavpmhGSSTSPDDLMHTLRAMWVV---RHPFLVHCADGIERTGLAIALDIGMqtlsrTNSCDPIKVIDELRQDRPECISHSVQY
 |   ......||        |  .....| ..|...  .    .| ||||  |. |||. .|... .     .. ... ......|. || .. .  |.
eregiqylhlpwpDh......gvpdllellleflefieealeeggpvlVHCsaGvgRtgtlvaaylmk.....klglsleealalvrsrrpgavpnpgql

ALLYK
  |..
rfLle
PH PH domain 437-541 3.9e-11 33.4 Pfam-A 2-103 (104) alignment 
Range on Protein: 437-541
Range on HMM: 2-103/104.0
RMAGWMHKRGsgggaFSGKGWRRRWFILQDTILKYFSRPS---ASTANGYINLTHDtNVRVHSDKE-FTIETPKRIFHLHCSDNqVQLLMNQTCPQSLNQ
 ..|...|..      . | |..|.|.|... | ||  ..   ...  | |.|.   .|.  |...    .. .  | ... ..  ..|.  . ......
ikeGyllkks.....ellktwkkryfvLtsnyLlyfksskkksykapkgsiplndc.tvkkasstkfgaqkesnnyfeitfknv.esyllsaeseeerkr

WVSIINAAI
||. .. ..
Wvqalknll
subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 177-277 8.7e-11 35.9 In-house 197-291 (310) alignment 
Range on Protein: 177-277
Range on HMM: 197-291/310.0
YVDWPeDSAVPMHGSSTSPDDLMHTLRamwvvRHPFLVHCADGIERTGLAIALDIGMQTLSRTNSCDPIKVIDELRQDRPECISHSVQYALLYKAMLIHC
. .|| |  ||     | |. |.  .|       | .|||. |..|... .||.. .. | | .  |  .|. ||...|  ||   .|| .. . ..| .
wpnwp.drgvpdekchtvpqrllaqvr.....hgpcvvhcsagkdrlyvvvalklkidkldrglkvdaeevktellksraiciqtelqyliidrvriifa

H
.
r
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 83-181 1.2e-08 28.8 In-house 237-329 (440) alignment 
Range on Protein: 83-181
Range on HMM: 237-329/440.0
YYIAAMSPTATSLLQFWLMIWENKVLSILMLSKIteqNRDQCAVYWPTEpgvTVKLPNGMLATCTSKEEKHHGSILRRITLKWGEEVRDLRHWQYVDWP
 .||.  |  ...|.|| .. . .. .|.|| ..   |   |..||| .   |  .  | ..      |.     .| . ||. ||| ..| ..   ||
afiatqmpldstvldfwrlvhdyristiimlnql...ndktcsiywpvn...trsvtfgpftvghkgsenmnrvkvrtlelkykeevheirqfevqtwp
subfamily_eak_pd Subfamily eak 62-185 1.5e-08 28.4 In-house 75-194 (332) alignment 
Range on Protein: 62-185
Range on HMM: 75-194/332.0
INsRGAYINANFVRgFDHEHCYYIAAMSPTATSLLQFWLMIWENKVLSILMLSKITEQNRDQCAVYWPTEPGVTvkLPNGMLAtCTSKEEKHHGSI-LRR
 | |  ||||  .  | .    || .  .  . .  || |. |.|  .|..| .  |.. ..   |.| .      |  |.|   . ||  ... .  | 
ln.rlGyinaslae.fsevGrkyiltGiasedkvfafwqmvleqkspaivqlledvelkleksdkyfpdktree..lkfGild.verkefvkrniletrl

ITLKWGEEVRDLRHWQYVDWPEDSA
. |. |.|   . |...  | | . 
lelskGnethrvlhykvfGwtettl
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 200-274 3e-08 27.9 In-house 219-293 (297) alignment 
Range on Protein: 200-274
Range on HMM: 219-293/297.0
HTLRAMWVVRHPFLVHCADGIERTGLAIALDIGMQTLSRTNSCDPIKVIDELRQDRPECISHSVQYALLYKAMLI
 .|||      . ||||. |. |.|. .  |. .. | .    |   ..  ||. |.  .    |. |||.|.| 
eslraemprnayllvhcsaGvGrsGvvvlsdvilaklrkkripdvaailsilreqrarlvqtleqfellydavlk
PH_8 Pleckstrin homology domain 454-516 4.1e-08 23.0 Pfam-A 11-75 (89) alignment 
Range on Protein: 454-516
Range on HMM: 11-75/89.0
GKGWRRRWFIL--QDTILKYFSRPSASTANGYINLTHDTNVRVHSDKEFTIETPKRIFHLHCSDN
..|...|.|.|  . . |.|.     |.  | | |...     ....|..|..  ....|. |..
lqgyakRfFvLdlksstlsYyrddnssalrgkiplslaiisaneekreiiidsGaevWeLkasne
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 210-273 5e-08 26.7 In-house 128-191 (440) alignment 
Range on Protein: 210-273
Range on HMM: 128-191/440.0
HPFLVHCADGIERTGLAIALDIGMQTLSRTNSCDPIKVIDELRQDRPECISHSVQYALLYKAML
 |.||||. |  |||. ||.|  ..   |..  | . .|. .|..||. .    |||....|.|
gpllvhcsagagrtgviiavdsilreakrsdqidifsfinsmrnnrpqmvqtpeqyafvheavl
PH_11 Pleckstrin homology domain 439-501 6e-08 22.8 Pfam-A 2-60 (112) alignment 
Range on Protein: 439-501
Range on HMM: 2-60/112.0
AGWMHKRGSGggafSGKGWRRRWFILQ-DTILKYFSRPSAStANGYINLTHDTNVRVHSDKEFT
.|.. | ||      .|||.||||||. |. |.|.  |.    .. . . .  .| .  | .. 
kGylkkkgsk....llkgWkrrwfiLrkdnvleYyksprdk.sdvalitkesekvilkkdlsis
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 67-147 7e-08 26.2 In-house 91-174 (349) alignment 
Range on Protein: 67-147
Range on HMM: 91-174/349.0
AYINANFVR--GFDHEHcYYIAAMSPTATSLLQFWLMIWENKVLSILMLSKITEQNRDQCAVYWPTE--PGVTVKLPNGMLATCT
 |||||...   .. |.  ||| . |  ...  |. .|  |.|  .| |..  |.. ..| .||      ..|||| | .| .. 
dyinanylkltrisvek.kyiatqaPlPstvddfykvillngvklvlsLnddkelslekcdiywqelsysnitvklqnsslyian
subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 211-283 9.2e-07 22.6 In-house 220-292 (302) alignment 
Range on Protein: 211-283
Range on HMM: 220-292/302.0
PFLVHCADGIERTGLAIALDIGMQTLSRTNSCDPIKVIDELRQDRPECISHSVQYALLYKAMLIHCHRRSQRP
. ..    |. | |  ..| . ...| . .      ..  .|..||. .    ||. || |.|..  .. ..|
ntvivSknGaGRagafltlavaveklqkgkepnikeivksiRsqRpravdslkQyvslyialllyikkkvtkp
subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 63-187 9.9e-06 19.3 In-house 118-237 (244) alignment 
Range on Protein: 63-187
Range on HMM: 118-237/244.0
NSRG-AYINANFVRGFDHeHCYYIAAMSPTATSLLQFWLMIWENKVLSILMLSKITEQNRdqcavYWPTEPGVTVkLPNGMLATCTSKEE-KHHGSILRR
 | | .|||| ||  .    . || .  | | . ..|| |. | .|  ...|  . |..      |||    .     . .  | | ..| |   .    
gsmgntyinasfvgclgr.taeyiltqhpladtsmdfwkmmlerhvnvlvvlgsveeede.....ywpdseplew.yeeditvtltdrdefknikasnle

ITLKWGEEVRDLRHWQYVDWPEDSAVP
|     |  . |  .|  .|| | . |
iesdmneshqaltmfqisnwpsdgttp