Gene MbrePTP-sf2-8 in Monosiga brevicollis

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily MbrePTP-sf2
Protein sequence
ID Type Fasta BLAST phosphatome Note
MbreP046_AA protein Get Run
MbreP046_AA_712-1001 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 716-1005 5.2e-124 407.6 In-house 1-269 (270) alignment 
Range on Protein: 716-1005
Range on HMM: 1-269/270.0
YKELPRGETHESDLPDYARGPRLNRFRDILPNPVTRVRLEPLEVDHTLEYINANYVRdpsapcdnkpallGFGGRRAKeYVAAQAPKDTGLFNFWRMIVH
.|||...||.|||||..|||..|||..||||.|.||||||.|| |.. .||||||||             || |...| |.||..|..|.|..|||||..
fkeldkeetsesdlpeaargkklnRyadiLPsPatRvrleeleedsataYinAnyvr.............Gfdgekkk.YiaamgPlpttlksfwrmiwe

VQARCIAMTTGLVEGGKNKCSRYWPAtiyaETKEELVYgpRDGKIHVRTMLVTKMEGYIKTNIQVLYQGSTRNLVHFWFTAWPDHGVPTRPDGSMQTQQM
.....|.|||||.| |..||.|||||    |.||.. .  .||||.|...  .|.||||.|.... ..|..|.|||||...|||||||...|.|..|.|.
ekvtaivmttgleEkgrkkCerYWpa....epkekvkl..edgkikvlalseekeegyiltrlrleekgeerrlvHfwyntWpdhgvpreedsslstdql

IEMLLDIRRTRNELDRAEsPLIVHCSAGIGRTGTMIALDHAMCALDMGVKVDVLSIVADIREDRMAMVQHVVQYRYLYQAVVEYAERLAA
..|| ..||...|||.|| ||.||||||.|||||.||||.|...|.. .|||||.|....|.||||.|||..||..||.||||||||.|.
lkmlravrrsekeldkae.PllvHcsaGvgRtGtlialDiavrlLeetkkvdvlaiieelRkdRmalvqhpeqyeflykavveyaerrak
0050432 (Phosphotyrosine protein) phosphatases II 729-1002 6e-68 224.8 In-house 62-301 (308) alignment 
Range on Protein: 729-1002
Range on HMM: 62-301/308.0
LPDYARGPRLNRFRDILPNPVTRVRLeplevDHTLEYINANYVRDPSapcdnkpallgfgGRRAKEYVAAQAPKDTGLFNFWRMIVHVQARCIAMTTGLV
     .   .||..||||.  .||.|     |..  ||||.||. .|              .. ....|.|.|... . .||||. . . |.| | | ||
vallpenkdkNrykdilpydhsRVkl.....degsdYInAsyvdgys.............sklprkfIatqgPlpntvedFwrmvweqnvrvIvmLtklv

EGGKNKCSRYWPATIYAETKEElvygprdGKIHVRTMLVTKMEGYIKTNIQVLY--QGSTRNLVHFWFTAWPDHGVPTRpdgsmqTQQMIEMLLDIRRTR
| |..|| .||| ..  ...|        ||..|... ......|....... .   | .| . ||..|.|||||||.       .......|  .|...
engrekcaqYwplelgggsley.......gkftvtllseevlddytvrtleltnlgdgesrtvthfhytnWpdhgvPps......peilldflelvrksl

neldrAESPLIVHCSAGIGRTGTMIALDHAMCALDMGVKVDVLSIVADIREDRMAMVQHVVQYRYLYQAVVEYAER
      ..| .||||||.|||||.||||.... |... .|||...|. .|| |. ||| . ||..||.|..||...
.....pggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtpeqylflyralleylkl
0051299 (Phosphotyrosine protein) phosphatases II 735-1000 2.8e-66 219.3 In-house 49-286 (288) alignment 
Range on Protein: 735-1000
Range on HMM: 49-286/288.0
GPRLNRFRDILPNPVTRVRLEPLEVDHTLEYINANYVRDPSAPcdnkpallgfggrraKEYVAAQAPKDTGLFNFWRMIVHVQARCIAMTTGLVEGGKNK
    ||..||||.  .||.| .|. ...  ||||.|.. .  .               ....|.|.|... . .||||. . . |.| | |.||| |..|
nleknRysdilpydhsRVkLsvldgvegsdYinAsyidgynlk...............rkfIatqgPlpntvedFWrmvweqnvrvIvmltklvelgrek

CSRYWPAtiyaetKEELVYGPrdgkIHVRTMLVTKMEGYIKTNIQVL------YQGSTRNLVHFWFTAWPDHGVPTrpdgsmQTQQMIEMLLDIRRTRNe
| .|||       .. |.||.    |.|... ......|......|       ..| .|.  ||..|.|||||||.       .......| ..|. .. 
caqYwpl......ggsltygd....itvtllseevlddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpd......spellldflrlvrkala.

ldRAESPLIVHCSAGIGRTGTMIALDHAMCALDMGVKVDVLSIVADIREDRMAMVQHVVQYRYLYQAVVEYA
    ..| .||||||.|||||.||||.... |. . .||||..|. .|| |. ||| . |||..|.|..||.
..sgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtpeqyrfvyealleyl
0046845 (Phosphotyrosine protein) phosphatases II 733-1002 1.6e-65 216.6 In-house 26-276 (284) alignment 
Range on Protein: 733-1002
Range on HMM: 26-276/284.0
ARGPRLNRFRDILPNPVTRVRLEPLEVD-HTLEYINANYVRDPSAPCDnkpallgfggRRAKEYVAAQAPKDTGLFNFWRMIVHVQARCIAMTTGLVEGG
     .||..||||.  .||.| .|. | .. .||||.||. .. .            .. |...|.|.|... . .||||. . ..|.| | |.||| |
penlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldlt..........yikkkfIatqgPlpntvedFwrmvweqnvrvIVmltelveng

KNKCSRYWPATiyaetKE---ElvygprdGKIHVRTMLVTKMEGYIKTNIQVLY---QGSTRNLVHFWFTAWPDHGVPTRpdgsmqTQQMIEMLLDIRRT
..||..||| .     .|           |...|... ......|....... .    | .| . ||..|.|||||||.       .....|.| ..|. 
rekcaqYwple.....gevlty.......gdftvtllseevkddytvrtleltnlgytgesrtvthfhytswpdhgvpps......pedlleflrlvrel

RNElDRAESPLIVHCSAGIGRTGTMIALDHAMCALDMGV---KVDVLSIVADIREDRMAMVQHVVQYRYLYQAVVEYAER
...    ..| .||||||.|||||.||||.... |. .    .||||..|. .|| |. ||| . |||..|.|..||. .
len.lpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyealleylkl
0040438 (Phosphotyrosine protein) phosphatases II 713-1008 1.3e-64 213.8 In-house 21-284 (317) alignment 
Range on Protein: 713-1008
Range on HMM: 21-284/317.0
IQGYKELPRGETHESDLPDYARGPRLNRFRDILPNPVTRVRLEPLEVDHTLEYINANYVRdpsapcdnkpallgfGGRRAKEYVAAQAPKDTGLFNFWRM
 .....|..   .. .   .   . .||..||||.. .||.| ||. |. . ||||.||                | .. ....|.|.|..  ...||||
leefedllslkldtysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyvd...............gpnlkrkfIatqgPlpntvedFwrm

IVHVQARCIAMTTGLVEGGKNKCSRYWPAtiyaetKEELVYgprdGKIHVRTMLVTKMEGYIKTNIQVL--YQGSTRNLVHFWFTAWPDHGVPTrpdgsm
. . . ..| | | |.| |..|| .|||       .|.|.|    |...|... .....|.. ....|   . . .| . ||..|.|||||||       
vweqgvtvivmLteleelgrekcaqYwpl......getlty....gdftvtllseeelagitlrtlevedlgdsesrtvthfhytgWpdhgvpp......

QTQQMIEMLLDIRRTRNeldRAESPLIVHCSAGIGRTGTMIALDHAMCALDMGVKVDVLSIVADIREDRMAMVQHVVQYRYLYQAVVEYAERLAAREQ
 .......|  .|. ..   . ..|..||||||.|||||.||.. ... |. . .||| ..|. .|| |. .||   |||.||.|. ||  |   .| 
spdllldfleavreale...dpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalleylkrkltlep
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 730-1004 1.5e-63 209.5 In-house 23-272 (274) alignment 
Range on Protein: 730-1004
Range on HMM: 23-272/274.0
PDYARGPRLNRFRDILPNPVTRVRLEPLEVDHT-LEYINANYVRDPSapcdnkpallgfggRRAKEYVAAQAPKDTGLFNFWRMIVHVQARCIAMTTGLV
.| ..  . ||...||||. .|| ||. ....  ..||||||.. ..              .. | |||.| |  . ...||||| . ... | |.| | 
ldvfgsqtknryktilPnensrvllesessededssyinanyikGyd..............eeskayvatqGPlpntvadfWrmiyqeevqvivmltklk

EGGKNKCSRYWPatiyaeTKEELVYGPRDGKIHVRTMLVTKMEGYIKTNIQVLYQGSTRNLVHFWFTAWPDHGVPTRPdgsmqtQQMIEMLLDIRRTRNE
|  ..||..|.|      ..|..    | |......  ... ..|  ... ..|. ..|...|.|.|.|||| .| ..      .......|.....|.|
eaneqkCavyfP......daedyeiserygdveikvekiverndysvrklvlkylerersvkhywytdWPdhksPdda......ntlldlvleveesree

LDRAESPLIVHCSAGIGRTGTMIALDHAMCALDMGVKVDVLSIVADIREDRMAMVQHVVQYRYLYQAVVEYAERLA
 .   .| .|||||||||||  || . |.  |.   .||||.||...| ||  |||   ||.....|...|..||.
enaklapvvvhCsaGiGrtGcfiaisiavrqlreeivvdvlkivcnlrldrGGmvqtseqyelihralclylkrll
DSPc_SM00195 737-1000 3.2e-63 208.9 In-house 28-262 (263) alignment 
Range on Protein: 737-1000
Range on HMM: 28-262/263.0
RLNRFRDILPNPVTRVRLEPLEVDHTLEYINANYVRDPsapcdnkpallgfggRRAKEYVAAQAPKDTGLFNFWRMIVHVQARCIAMTTGLVEGGKNKCS
. ||...|||.  |||.|.. | . . .||||||.. .               .. |.|.|.|.|... .  ||||... . ..|.|.|  .| ||.||.
sknRyknilpydhtrVklkkeekkegsdYINAnyikga...............nkkkkyIatQgPlpstvedFWrmvweekvkiivmlteeeengkekcd

RYWPATIyaetKEELVYGprdgKIHVRTMLVTKME-GYIKTNIQVLYQG--STRNLVHFWFTAWPDHGVPtrpdgsMQTQQMIEMLLDIRRTRNELdraE
|||| ..    ... ..|    ||.| .. |.|..  .|...... ..|   ||.. ......|||||||       .|....|.|  .. ....    .
rywpees....ggketfg....kisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvp......dstksvlellravkksksts...s

SPLIVHCSAGIGRTGTMIALDHAMCALDMGVKVDVLSIVADIREDRMAMVQHVVQYRYLYQAVVEYA
.|..||||||.|||||....| ..  |... |||. .||  .|. |. |||   ||...|.|..||.
gpivVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi
PTPc_SM00194 737-1000 3.2e-63 208.9 In-house 28-262 (263) alignment 
Range on Protein: 737-1000
Range on HMM: 28-262/263.0
RLNRFRDILPNPVTRVRLEPLEVDHTLEYINANYVRDPsapcdnkpallgfggRRAKEYVAAQAPKDTGLFNFWRMIVHVQARCIAMTTGLVEGGKNKCS
. ||...|||.  |||.|.. | . . .||||||.. .               .. |.|.|.|.|... .  ||||... . ..|.|.|  .| ||.||.
sknRyknilpydhtrVklkkeekkegsdYINAnyikga...............nkkkkyIatQgPlpstvedFWrmvweekvkiivmlteeeengkekcd

RYWPATIyaetKEELVYGprdgKIHVRTMLVTKME-GYIKTNIQVLYQG--STRNLVHFWFTAWPDHGVPtrpdgsMQTQQMIEMLLDIRRTRNELdraE
|||| ..    ... ..|    ||.| .. |.|..  .|...... ..|   ||.. ......|||||||       .|....|.|  .. ....    .
rywpees....ggketfg....kisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvp......dstksvlellravkksksts...s

SPLIVHCSAGIGRTGTMIALDHAMCALDMGVKVDVLSIVADIREDRMAMVQHVVQYRYLYQAVVEYA
.|..||||||.|||||....| ..  |... |||. .||  .|. |. |||   ||...|.|..||.
gpivVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi
subfamily_PTPRB_pd Subfamily PTPRB 726-1002 3.6e-62 205.1 In-house 42-287 (293) alignment 
Range on Protein: 726-1002
Range on HMM: 42-287/293.0
ESDLPDYARGPRLNRFRDILPNPVTRVRLEPLEVDHTLEYINANYVRDPSAPcdnkpallgfggrraKEYVAAQAPKDTGLFNFWRMIVHVQARCIAMTT
. .  . |.    ||...|||   .||.|..|. ... .||||||... ..|               .|..|.| |  . . .||||.   ... | | |
avkaaelavnraknrytnilpydhsrvkLaalkdesgsDYinanyipgynsp...............refiatqGPlpetvddfWrmvwekkssiivmlt

GLVEGGKNKCSRYWPATiyaetKEELVYgprdGKIHVRTMLVTKMEGYIKTNIQVLYQGSTRNLVHFWFTAWPDHGVPtrpdgsMQTQQMIEMLLDIRRT
 |||.|| || .||||.     .|. .|    |.|.|  .  ...| ..  ....  . ..|.. .. ||.|||||||       .|.......  .|..
qlvekgkvkCeeYWPad.....eepvly....GdikvtlvaeeeledwvirelkiekekeerkvrqyhftsWpdhgvP......ektktlldfvrtvrea

rNELDRAESPLIVHCSAGIGRTGTMIALDHAMCALDMGVKVDVLSIVADIREDRMAMVQHVVQYRYLYQAVVEYAER
  | . ...|..||||||.||||| ||||. . |..    ||...|||..||.|. .|| . || ...|.|... ..
.iektaskrPivvhCsaGvGRtGtfialdrllqaieeedyvdifgivaelReeRnllvqtekqYifihqcvldllrk
0043336 (Phosphotyrosine protein) phosphatases II 714-999 5.4e-62 205.1 In-house 24-276 (278) alignment 
Range on Protein: 714-999
Range on HMM: 24-276/278.0
QGYKELPRGETHESDLPDYARGPRLNRFRDILPNPVTRVRLEPLEVDHTLEYINANYVRdpsapcdnkpallgfGGRRAKEYVAAQAPKDTGLFNFWRMI
....||..  . . .   .     .||..||||.. .||.|..|. |  . ||||.||                | .. ....|.|.| .  . .||||.
lefeellsfkldtysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyvd...............gynvprkfiatqgPlpetvedFwrmv

VHVQARCIAMTTGLVEGGKNKCSRYWPatiyaetKEELVYGPrdgkIHVRTMLVTKMEGYIKTNIQVL--YQGSTRNLVHFWFTAWPDHGVPTrpdgsmQ
 . . ..| | |.||| |..|| .|||       .. |.||.    ..|... ......|. ... |   . | .|  .|.....|||||||.      .
welgvttivmLtelvelgrvkcaqYwp.......ggsltygd....ftvtllkeehlddytvrtlevtnlgdgesrtvthyhylgwpdhgvpe......s

TQQMIEMLLDIRRTRNeldRAESPLIVHCSAGIGRTGTMIALDHAMCALDMGVKVDVLSIVADIREDRMAMVQHVVQYRYLYQAVVEY
.......| ..|. ..     ..|..||||||.|||||.|||. ... |. . .||....|...|| |. .||   |||.||.|. ||
lsllldflkavreale...dsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflyealley
0036941 (Phosphotyrosine protein) phosphatases II 737-1002 3.2e-61 202.6 In-house 41-279 (297) alignment 
Range on Protein: 737-1002
Range on HMM: 41-279/297.0
RLNRFRDILPNPVTRVRLepleVDHTLEYINANYVRdpsapcdnkpallgfGGRRAKEYVAAQAPKDTGLFNFWRMIVHVQARCIAMTTGLVEGGKNKCS
 .||..||||.. |||.|     |    ||||.||                | .. ....|.|.|... . .||||. . . ..| | | ||| |..|| 
eknRykdilpydhtRVkl....ddegsdYinAsyvd...............gydlkrkfIatqgPlpntvedFWrmvweqnvtvIvmltelvelgrekca

RYWPATiyaeTKEELVYgprdGKIHVRTMLVTK--MEGYIKTNIQVLY--QGSTRNLVHFWFTAWPDHGVPTrpdgsmQTQQMIEMLLDIRRTRNELdRA
.||| .    . |.|.|    |...|... |..   ..|. ....|..   | .| . ||..| |||||||.       ........  .|. ...| . 
qywple....egeslty....gdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpe......spaslldfielvrkvlkll.ps

ESPLIVHCSAGIGRTGTMIALDHAMCALD---MGVKVDVLSIVADIREDRMAMVQHVVQYRYLYQAVVEYAER
..| .||||||.||.||.||.| ... |.   .  .||.|..|  .|| |. .|| . |||.||.|. |.  .
ggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallellkk
subfamily_PTPRD_pd Subfamily PTPRD 714-1020 1.5e-60 200.5 In-house 27-301 (564) alignment 
Range on Protein: 714-1020
Range on HMM: 27-301/564.0
QGYKELPRGETHESDLPDYARGPRLNRFRDILPNPVTRVRLEPLEVDHTLEYINANYVRdpsapcdnkpallGFGgrRAKEYVAAQAPKDTGLFNFWRMI
. ||.. .|.... .  ..    . ||. .|..   .||.|...| |.  .||||...              |.   . |.|.|.|.|. . . .||||.
eeykkieegqqftweaankpaNkaKNRyanivaYdhsRVvLskvegdegsDYINAsfid.............gyr..krkayIAtqgPlaetiedFWRmv

VHVQARCIAMTTGLVEGGKNKCSRYWPAT---IYAETKEELVYGPRDGKIHVRTMLVTKMEgyiktniqvlyQGSTRNLVHFWFTAWPDHGVPTRPdgsm
   . ..| | | |.| ||.||..|||..    | | . .|.   .  ....||. ..| .           . ..|.  .| ||.|||||||. .    
weqnsstiVmltkleEkgkvkchkYWPekgtetygeltVtleeeeeladyeirtfklkkkk...........ssesreVrqFhFtsWPdhgvpesa....

qtQQMIEMLLDIRRTRNeldRAESPLIVHCSAGIGRTGTMIALDHAMCALDMGVKVDVLSIVADIREDRMAMVQHVVQYRYLYQAVVEYAERLAAREQEE
  ....... ..|....   . . |..||||||.||||| |..|  .  .    .||. ..|. .|..| ||||   || ....|..|. .      . |
..tslLdlirkvralne...pdagPivVhCSaGVGRTGtfividamlerikeektvDiyqyvkalrkqRnamVqteeQYiFiheailealacgntevese

EAAQAYEQMR
.  |. ....
nlkqhlqkLa
0047943 (Phosphotyrosine protein) phosphatases II 736-1000 1.9e-60 200.0 In-house 39-272 (273) alignment 
Range on Protein: 736-1000
Range on HMM: 39-272/273.0
PRLNRFRDILPNPVTRVRLepleVDHTLEYINANYVRDPsapcdnkpallgfggRRAKEYVAAQAPKDTGLFNFWRMIVHVQARCIAMTTGLVEGGKNKC
  .||..||||.  .||.|     | .  ||||.||. .               .. ....|.|.|..  . .||||. . ..|.| | | ||| |..||
kdknrykdilpydhsrvkl....gdggsdyinAsyvdgy...............nlkrkfiatqgPlpntvedfwrmvweqnvrviVmLtelvelgrekc

SRYWPATIYAetkEELVYGPrdgkIHVRTMLVTKMEGYIKTNIQVLY--QGSTRNLVHFWFTAWPDHGVPTRPDGSMQTQQMIEMLLDIRRTRneldrae
 .||| .       .|.||.    ..|... ... ..|....... .   | .|   ||..| |||||||. ..  ..  ....  |   .         
aqYwplegge...lsltygk....ftvtllseetkddytvrtleltnlgtgesrtvthfhytgwpdhgvppslesllefielvrkalealpsn.......

SPLIVHCSAGIGRTGTMIALDHAMCALDMGVKVDVLSIVADIREDRMAMVQHVVQYRYLYQAVVEYA
.| .||||||.|||||.||||.... | .. .||||..|. .|. |. ||| . |||.||.|..||.
gpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrflyealleyl
0039614 (Phosphotyrosine protein) phosphatases II 733-1001 1.3e-59 197.5 In-house 54-290 (297) alignment 
Range on Protein: 733-1001
Range on HMM: 54-290/297.0
ARGPRLNRFRDILPNPVTRVRLEPLEV-DHTLEYINANYVRDPSApcdnkpallgfggrRAKEYVAAQAPKDTGLFNFWRMIVHVQARCIAMTTGLVEGG
     .||..||||.. .||.| |..  |. . ||||.||  ..               . ....|.|.| .  . .||||. . . ..| | | ||| |
penkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydl..............ltrkfIatqgPlpetvedFwrmvweqgvtvivmLtklvelg

KnKCSRYWPATIYaetkeelvygpRDGKIHVRTMLVTKMEGYIKTNIQVLYQGSTRNLVHFWFTAWPDHGVPTRPDGSMQTQQMIEMLLDIRrtrneldR
. || .||| .             . |...|... |.. .||. ... | . | .| . ||..| |||||||  ..  ..  ....  |          .
r.kcaqywpeegg...........tygdftvtllkvehldgytvrtlevtnngesrtvthfqytgwpdhgvppslellleflelvrealael.......p

AESPLIVHCSAGIGRTGTMIALDHAMCALDMGVKVDVLSIVADIREDRMAMVQHVVQYRYLYQAVVEYAE
 . | .||||||.|||||.||.. ... |. . .||||..|. .|| |. .||   |||.||.|..|.  
kggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydallellk
0045450 (Phosphotyrosine protein) phosphatases II 736-999 3.7e-59 196.3 In-house 56-303 (307) alignment 
Range on Protein: 736-999
Range on HMM: 56-303/307.0
PRLNRFRDILPNPVTRVRLEPLEVD-HTLEYINANYVRDPSAPcdnkpalLGFGGRRAKEYVAAQAPKDTGLFNFWRMIVHVQARCIAMTTGLVEGGKNK
  .||..||||.. |||.| .|. . ..  ||||.|||.|.         |. | .. ....|.|.|..  . .||||. . . ..| | |.||| |..|
kdknrykdilpydhtRVklssldgsledsdYiNAsyvrvplll.......lldgydlkrkfIatqgPlpetvedFwrmlweqgvtvivmltelvelgrek

CSRYWPATiyaetKEELVYGPrdgkIHVRTMLVTKMEGYIKTNIQVL---YQGSTRNLVHFWFTAWPDHGVPTrpdgsmQTQQMIEMLLDIRRTRNELdR
| .||| .     .|||.||.    ..|... .....||. ... |    . | .| . ||..|.|||||||.       ........  .|. ..|| .
caqywPde.....geeltygn....ftvtllseehldgytvrtlevtdldgtgesrtvthfhytgwpdhgvpp......sfeelldfieevrkaleel.p

AESPLIVHCSAGIGRTGTMIALDHAMCALDMGVK---VDVLSIVADIREDRMAMVQHVVQYRYLYQAVVEY
 ..| .||||||.|||||.||.. ... |. . .   ||.|..|. .|| |. .||   |||.||.|. |.
kggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyeallel
0042113 (Phosphotyrosine protein) phosphatases II 736-1000 5.9e-57 188.2 In-house 10-243 (245) alignment 
Range on Protein: 736-1000
Range on HMM: 10-243/245.0
PRLNRFRDILPNPVTRVRLEPLEVDHTLEYINANYVRdpsapcdnkpallgfGGRRAKEYVAAQAPKDTGLFNFWRMIVHVQARCIAMTTGLVEGGKNKC
. .||..||||.. |||.| | . |  . ||||.||                | |. . . |.|.| .  . .||||. . . ..| | | ..| |..||
kdknrysdilpydhtrvklspdggdldsdyinasyvd...............gyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkc

SRYWPAtiyaetKEELVYgprdGKIHVRTMLVTKMEGYIKTNIQVL--YQGSTRNLVHFWFTAWPDHGVPTRPDGSMQTQQMIEMLLDIrrtrneldRAE
 .|||       .|.|.|    |...|... ......|. ....|   . . .|. .|.... |||||||. ..   .  ....  |           ..
aqywpl......geslty....gdftvtllseehlddytvrtlevtnlgddesrevihyhylpwpdhgvpdllellldflefvrkalae........dsn

SPLIVHCSAGIGRTGTMIALDHAMCALDMGVKVDVLSIVADIREDRMAMVQHVVQYRYLYQAVVEYA
 |..||||||.|||||.||.. ... |.   .|.. ..|...|. |. .||   |||.||.|. |. 
gpvlVHCsaGvgRtGtfiaaylmleqlekelgvsleeavkelrsqRpgavqtpsqyrflyeallell
subfamily_PTPN6_pd Subfamily PTPN6 739-1005 2.9e-56 185.7 In-house 58-300 (306) alignment 
Range on Protein: 739-1005
Range on HMM: 58-300/306.0
NRFRDILPNPVTRVRLEpLEVDHTLEYINANYVRdPSAPCDNkpallgfggrraKEYVAAQAPKDTGLFNFWRMIVHVQARCIAMTTGLVEGGKNKCSRY
||.. |||   ||| |.  .     .||||||..  ...  .            |.|.|.|   .| . .||||..  ..| | |||  || ||.||.||
nryknilPfDhtrvilk.epsvpgsdyinanyik.kevkgsd............ksyiatqgclettvsdFWrmvwqensrvivmttkevErgkekCarY

WPATiyaETKEElvYgprdGKIHVRTMLVTKMEGYIKTNIQVL---YQGSTRNLVHFWFTAWPDHGVPTRPdgsmqtQQMIEMLLDIRRTRNELD-RAES
||..   |.|||  |    |||.|...  .... ||  ...|     ....|..... |..|||||||. |      ......| |..| ..||  . . 
WPde...eekee..y....GkisvtnvseksladYilRelsvskkkkkkeerevfqyhfksWPdhgvpkdp......gavLdfledvnrkqeeleeaeag

PLIVHCSAGIGRTGTMIALDHAMC---ALDMGVKVDVLSIVADIREDRMAMVQHVVQYRYLYQAVVEYAERlaA
|..||||||||||||.| .|  .       . ...|. ..|  .|| |  .||   ||...|.|. .| |.   
pivvhCsaGiGRtGtfiviDillkliekkgldadidiqklvksvreqrsglvqteqqykfvykaikkyiet..k
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 737-1002 8.4e-56 184.1 In-house 43-278 (281) alignment 
Range on Protein: 737-1002
Range on HMM: 43-278/281.0
RLNRFRDILPNPVTRVRLEPLEVDHTLEYINANYVRdpsapcdnkpallgfGGRRAKEYVAAQAPKDTGLFNFWRMIVHVQARCIAMTTGLVEGGKNKCS
  ||...|     |||...| | ... .|||||.|                | .  |||.|.|.|  . | .||.|..  ... |.| |  .|.|| || 
lknrYsnivaYDatrvkvtpneenkntDYinanfvp...............gykgekeyiatqgPvPaslvafWqmvweqkvsaivmvtreieagklkCh

RYWPATIYaetkeELVYgprdGKIHVRTMLVTKMEGYIKTNIQV-LYQGSTRNLVHFWFTAWPDHGVPTrpdgsmQTQQMIEMLLDIRRTRNEldRAESP
||||         || |    |...|...  .. . ||. ....   .| ||..... .|||||||||.      .|....|   ........  . . |
rYWPddns.....elky....gdvtvkstaeeekatyierkfkleresgetreveqlaytaWPdhGvPa......ttkellefrkevlkltek..ktkap

LIVHCSAGIGRTGTMIALDHAMCAL-DMGVKVDVLSIVADIREDRMAMVQHVVQYRYLYQAVVEYAER
|..|||||.||||| |||| .. |. ..  ..||  .||..|..|. ||| ||||...|.||... ..
lvihCsaGvGrtGtyialDrlvkaveaeleeldvkavvaelrkernlmvqtvvqyefvykavldaldk
subfamily_PTPN12_pd Subfamily PTPN12 737-1005 1.2e-55 183.4 In-house 42-282 (290) alignment 
Range on Protein: 737-1005
Range on HMM: 42-282/290.0
RLNRFRDILPNPVTRVRLEPLEVDHTLEYINANYVRDPSAPcdnkpallgfggrraKEYVAAQAPKDTGLFNFWRMIVHVQARCIAMTTGLVEGGKNKCS
. ||..||||   .|| |.  | ..  .|||||... .. .               .||.|||.|  . | .||||| ... . . |   .|| ||.|| 
kknrykDilPydksrvelskieeeegsdYinanfikgvegk...............leyiaaqgPLpktlddfWrmiweknveivvmaCrevelgkkkCe

RYWPAtiyaETKEELVYGprdgKIHVRTMLVTKME-GYIKTNIQVLYQGSTRNLVHFWFTAWPDHGVPTRPDgsmqtqQMIEMLLDIRRTRNeldRAESP
||||     |..||| .|    ...| ..   ... ...   ..|  |. .|..  | .|||||||||....      ...|.. ..|....   . ..|
rYWpe....egeeelefg....efevtleeekavdddflirtLkveaqkesrkvyqfhYtaWPDhgvPssak......sllelielvrelqe...sedaP

LIVHCSAGIGRTGTMIALDHAMCALDMGVK---VDVLSIVADIREDRMAMVQHVVQYRYLYQAVVEYAERLAA
|.||||||.|||||.||.|..  .|  .     .|| ..|...|..| |.||   ||...|.||.|. ..  .
lvvhCsaGvGrtGtiiaidyvrellkaekipeeldvfdlvlelrkqraalvqtkeqyelvykavaelvqkele
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 716-1001 2.7e-55 182.5 In-house 27-280 (288) alignment 
Range on Protein: 716-1001
Range on HMM: 27-280/288.0
YKEL-PRGETHESDLPDYARGPRLNRFRDILPNPVTRVRLEPLEVDHTLEYINANYVRDpsapcdNkpallgfggRRAKEYVAAQAPKDTGLFNFWRMIV
|. | . ..|....    |.  . ||.|.|||   .||.|. ||  .. .||||.|. .      .         .. |.|.|.|.|    . .||... 
ynsLaalektksvtagrlavnakknRyrnilpyDekrvklkkleeeagaDYinasyidg......e.........kkkkkyiatqgPladtvndfWelvy

HVQARCIAMTTGLVEGGKNKCSRYWPATiyaetKEELVYgprdGKIHVRTMLVTKMEGYIKTNIQVLYQGSTRNLVHFWFTAWPDHGVPTrpdgsmQTQQ
  ..  |.| |.||||||.|| .|||..     ...  |    |.. |  . . ..| ... .. .  ... ... .. ..||||||||       ....
enktstivmltelveggktkCeeYWPda.....dkpkny....GsvtvtlveskeledfvlrklllekkkteleitqyqylaWpdhgvPe......skap

MIEMLLDIRRTRNELdraESPLIVHCSAGIGRTGTMIALDHAMCALDMGVKVDVLSIVADIREDRMAMVQHVVQYRYLYQAVVEYAE
..|.|  .  . ..      |.|||||||.||||| |||| .. |..   ..||...|| .|. |. .|| . || ..|..... .|
llellrqvkvanqad...tgpiivhCsaGvGrtgtFialdalidaveeedyiDvagtvaklRkqRallvqtlkqYefiyevllslie
Y_phosphatase Protein-tyrosine phosphatase 738-998 3.5e-55 182.4 Pfam-A 4-235 (235) alignment 
Range on Protein: 738-998
Range on HMM: 4-235/235.0
LNRFRDILPNPVTRVRLEPLEVDHTleYINANYVrdpsapcdnkpallgFGGRRAKEYVAAQAPKDTGLFNFWRMIVHVQARCIAMTTGLVEGGKNKCSR
 ||..||||   |||.|.  | ..   |||||||                | .. |...|.|.| .  .  ||||... . ..|.| | |.| |..||..
knRykdilpydktrvklkgsegpsd..YInAnyv...............kgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaq

YWPatiyAETKEELVYgprdGKIHVRTM-LVT-KMEGYIKTNIQVLYQGST---RNLVHFWFTAWPDHGVPTRpdgsmqTQQMIEMLLDIRRTRnelDRA
|||     |..|.| |    |.|.|...  .. ....|. .....  ...    | . ....|.|||||||.       ........ ......   .  
Ywp....eeeeeslty....gdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpes......pkslldlirkveksk...eak

ESPLIVHCSAGIGRTGTMIALDHAMCALDMGVKVDVLSIVADIREDRMAMVQHVVQYRYLYQAVVE
..|..||||||.|||||..||| ... |. . .||||.||  .|. |. ||| . || .||.|..|
sgpvvVhCsaGvgRtgtfvaldilleqleaeeevdvlqivkelRkqRpgmvqsleqYiflykaile
Y_phosphatase Protein-tyrosine phosphatase 738-998 3.5e-55 182.4 In-house 4-235 (235) alignment 
Range on Protein: 738-998
Range on HMM: 4-235/235.0
LNRFRDILPNPVTRVRLEPLEVDHTleYINANYVrdpsapcdnkpallgFGGRRAKEYVAAQAPKDTGLFNFWRMIVHVQARCIAMTTGLVEGGKNKCSR
 ||..||||   |||.|.  | ..   |||||||                | .. |...|.|.| .  .  ||||... . ..|.| | |.| |..||..
knRykdilpydktrvklkgsegpsd..YInAnyv...............kgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaq

YWPatiyAETKEELVYgprdGKIHVRTM-LVT-KMEGYIKTNIQVLYQGST---RNLVHFWFTAWPDHGVPTRpdgsmqTQQMIEMLLDIRRTRnelDRA
|||     |..|.| |    |.|.|...  .. ....|. .....  ...    | . ....|.|||||||.       ........ ......   .  
Ywp....eeeeeslty....gdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpes......pkslldlirkveksk...eak

ESPLIVHCSAGIGRTGTMIALDHAMCALDMGVKVDVLSIVADIREDRMAMVQHVVQYRYLYQAVVE
..|..||||||.|||||..||| ... |. . .||||.||  .|. |. ||| . || .||.|..|
sgpvvVhCsaGvgRtgtfvaldilleqleaeeevdvlqivkelRkqRpgmvqsleqYiflykaile
0040439 (Phosphotyrosine protein) phosphatases II 735-999 7e-55 181.7 In-house 11-245 (249) alignment 
Range on Protein: 735-999
Range on HMM: 11-245/249.0
GPRLNRFRDILPNPVTRVRLEPLEVDHTLEYINANYVrdpsapcdnkpallgFGGRRAKEYVAAQAPKDTGLFNFWRMIVHVQARCIAMTTGLVEGGKNK
 . .||..||||.. .||.|..|.      ||||.|.                | .. ....|.|.| .  . .||||. . . ..| | | ||| |..|
nkdknrypdilpydhsrvklsilpglflsdyinAsyi...............dgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrek

CSRYWPAtiyaetKEELVYgprdGKIHVRTMLVTKMEGYIKTNIQVL--YQGSTRNLVHFWFTAWPDHGVPTRPDGSMQTQQMIEMLLDIRrtrneldRA
| .|||       ...|.|    |...|... |.....|. .....   | |..|   |...| |||||||  ..  ..  ....  |.         . 
caqywpl......ggsley....gdftvtllsvevkddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleel.......pk

ESPLIVHCSAGIGRTGTMIALDHAMCALDMGVKVDVLSIVADIREDRMAMVQHVVQYRYLYQAVVEY
..|..||||||.|||||.||.. ... |.   .||....|...|. |. .||   |||.||.|. |.
ggpvlVHCsaGvgRtGtfiaaylmleqlekelgvdleeavkllrsqRpgavqnpeqyrflyeallel
0045098 (Phosphotyrosine protein) phosphatases II 732-1002 1.5e-54 180.6 In-house 30-274 (278) alignment 
Range on Protein: 732-1002
Range on HMM: 30-274/278.0
YARGPRLNRFRDILPNPVTRVRleplevdhtlEYINANYVrdpsapcdnkpallgfGGRrAKEYVAAQAPKDTGLFNFWRMIVHVQARCIAMTTGLVEGG
|  .  .||..||||.. .||.          .||||.|.                 |   |...|.|.|... . .||||. . . ..| | |.|||.|
ylgnldknRykdilpydhsrVk..........dYINAsyi................dgy.pkkfIatqgPlpstvadfwrmlwelgitvivmltelvelg

KNKCSRYWPAtiyaetKEELVYgprdGKIHVRTMLVTKMEGYIKTNIQVL------YQGSTRNLVHFWFTAWPDHGVPTRP--DGSMQTQQMIEMLL---
..|| .|||       .. |.|    |...|... .. .. |... . |       . . .|.. |.... |||||||. |  .   .  ..|.  |   
rekcaqywpe......ggslty....gdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkll

-DIRRTRNELDRAESPLIVHCSAGIGRTGTMIALDHAMCALdmGVKVDVLSIVADIREDRMA-MVQHVVQYRYLYQAVVEYAER
 .  .... |.  . | .||||||.|||||..|..  .. |  . .||.|..|. .|. |.  .||.  |||.||....|. .|
aslllsslllldsggpvlVHCsaGvgRtGtlvaaylmlell..eggvdlleavkelrsqRpglavqnleqyrflyefllelllr
0037934 (Phosphotyrosine protein) phosphatases II 737-999 1e-51 171.2 In-house 12-241 (243) alignment 
Range on Protein: 737-999
Range on HMM: 12-241/243.0
RLNRFRDILPNPVTRVRLeplevDHtLEYINANYVRDPsaPcdnkpallgfggrrakEYVAAQAPKDTGLFN----FWRMIVHVQARCIAMTTGLVEGGK
  ||..||||.. .||.|     .    |||||... .  |                 . | |.| .  ...    ||||. . . ..| | | ||| |.
sknrysdilpydhsrvkl.....eg.sdyinanliyvt..p................rliatqgPlpetveddlasfwrmlwelgitvivmltelvElgr

NKCSRYWPatiyaetkEELVYGPrdgkIHVRTMLVTKMEGYIKTNIQVLY---QGSTRNLVHFWFTAWPDHGVPTRpdgsmqTQQMIEMLLDIRRTRNE-
.|| .|||        .| .||.    ..|... .. ...|. ..... .   .. ||. .|.....|||||||.       .......| ..|   .| 
ekcaqywp........gevtygd....ftvtllseehlddytvrtlllenldlddltrlvihyhylpwpdhgvPds......pedlldfldevrefieel

----LDRAESPLIVHCSAGIGRTGTMIALDHAMCALdmgvKVDVLSIVADIREDRMA-MVQHVVQYRYLYQAVVEY
     .  ..|..||||||.|||||.||..  .  |    .||....|...|| |.  .||   |||.||.|. |.
lsllaldsggpvlVHCsaGvgRtGtliaaylmllll....gvdleeavkllreqRpgkavqtpsqyrflyeallel
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 738-1021 2.1e-51 169.9 In-house 49-301 (318) alignment 
Range on Protein: 738-1021
Range on HMM: 49-301/318.0
LNRFRDILPNPVTRVRLEPLEVDHTLEYINANYVRdpsapcdnkpallgfGGRRAKEYVAAQAPKDTGLFNFWRMIVHVQARCIAMTTGLVEGGKNKCSR
 ||. .||.   |||.|..||.... .||||||.                | || |.|.|||||    . .||||.   ... | | | ..| ||.|. |
knryanilaydhtrvkLqmlegeegsDyinanyid...............GyrrkkayiaaqaPlpetieDfWrmvWeqnsavivmltqeeergkakvhr

YWPAtiyaetKEELVYgprdGKIHVRTMLVTKMEGYIKTNIQVLYQG--STRNLVHFWFTAWPDHGVPTRPdgsmqtQQMIEMLLDIRRTRNelDRAESP
|||       |.   |    ||..|  .  .... |.  ...|  ..  ..|.   . .|.|||.|||. .       ...... ..... .  .  ..|
yWPs......kgsrsy....gklvvelkeevelsdyvlrefkvtrteeeesrqvrqyhytsWpdegvpesg......aslldlvrqvskaqq..ksgagp

LIVHCSAGIGRTGTMIALDHAMCALDMGVKVDVLSIVADIREDRMAMVQHVVQYRYLYQAVVEYAERLAAREQEEEAAQAYEQMRE
..||||||.||||. ||.|  .  .     |||. .|  .|| | .|||   || ..|....|. .   .  . .. ..  ...||
ivvhCsaGvGrtGvfiavdillerikaealvDvfqtvkqlreqrnlmvqtedqyefiydvllealasgdtevdasdlrsrirelre
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 723-1003 2.6e-51 169.6 In-house 36-286 (319) alignment 
Range on Protein: 723-1003
Range on HMM: 36-286/319.0
ETHESDLPDYARGPRLNRFRDILPNPVTRVRLEPLEVDHTLEYINANYVRdpsapcdnkpallGFggRRAKEYVAAQAPKDTGLFNFWRMIVHVQARCIA
.. . |  .  .  . ||...||.   ||| | .|.  .  .||||...              |.  .. ....|.|||... . .||||. . .. .. 
vndtfdsaskeenkkknryqnilaydrtrvvlseldgvegsdyinasfid.............gy..qerekfiatqaPlentiedfWrmvWeeessivv

MTTGLVEGGKNKCSRYWPATIYAEtkeelvYgprdGKIHVRTMLVTKMEGYIKTNIQVLYQG---STRNLVHFWFTAWPDHGVPTrpdgsmQTQQMIEML
| |.||| .| |...||| . . |      |    |.. |      ..|.||. ....  .     ||...|| .|.||||.||.      ........|
mltklveklkvklkkywpeenfee......y....GrlivtleeeeeledyiirklklnkkssevetRevkhfqyteWpdhdvPe......katslldll

LDIRRTRNEldRAESPLIVHCSAGIGRTGTMIALDHAMCALDMGVKVDVLSIVADIREDRMAMVQHVVQYRYLYQAVVEYAERL
 .||..|..    . |..||||||.||||| |.|| ..  .     .|| |.|  .|  |  |||.  ||...|.|..|..|  
krirksrek..tqsgPivvhCsaGvGRtGtfivldamlervkeegvlDvfstvsrlRtqRnimvqrpeqYkfiyealleaveag
subfamily_PTPN3_pd Subfamily PTPN3 738-999 3.6e-51 168.7 In-house 44-274 (280) alignment 
Range on Protein: 738-999
Range on HMM: 44-274/280.0
LNRFRDILPNPVTRVRLEPLEVdhtlEYINANYVRDPSaPcdnkpallgfGGRRAKEYVAAQAPKDTGLFNFWRMIVHVQARCIAMTTGLVEGGKNKCSR
 ||.|||||   |||.|.  |.    .|||||||   . |          .    . |.|.| | ..   .||.|. . ... | | | ||| |. || .
knryrdilpydatrvklkeset....dyinanyvnmei.p..........stglvnryiatqGPlaktatdfWqmvweqksslivmlttlverGrvkChq

YWPAtiyaeTKEELVYGprdgKIHVRTMLVTKMEGYIKTNIQVLYQG--STRNLVHFWFTAWPDHGVPTRPdgsmqtQQMIEMLLDIRRTRnelDRAESP
|||      |..|| ||    ...|.     . . |.  .. .  .     |..... ..||||||||. .      ....|..  .|..|     .|.|
yWPe.....tedeleyg....efsvkcekedetksyvlrelvlkdketkeerkilqlqylaWpdhgvPdds......adflefvervrklr...sgkeeP

LIVHCSAGIGRTGTMIALDHAMCALDMGVKVDVLSIVADIREDRMAMVQHVVQYRYLYQAVVEY
..||||||||||| .|.|. |.. ...  .| .| ||  .|. |...|| . ||... .|... 
vvvhCsaGigrtGvlilletalalieaaepvypldivrtmrdqramlvqtasqykfvCeailkv
subfamily_PTPN9_pd Subfamily PTPN9 737-1003 2.3e-50 166.3 In-house 44-293 (297) alignment 
Range on Protein: 737-1003
Range on HMM: 44-293/297.0
RLNRFRDILPNPVTRVRLEPLEVDHTLEYINANYVRdpsapcdnkpallgfGGRRAKEYVAAQAPKDTGLFNFWRMIVHVQARCIAMTTGLVEGGKNKCS
. ||. |.|    ||| |. .. |.. .|||||.|                | .. | ..|.| | .    .||||.   ... | ||| .|| |. ||.
eknrytdvlcydetrvvlakvdedeasdyinanfvd...............GykqkkafiatqGplkktvsdfWrmvWeqevlvivmttrvvergrlkcg

RYWPATiyAETKEElvYgprdGKIHVRTMLVTKMEGYIKTNIQVL--YQGSTRNLVHFWFTAWPDHGVPTRPDGSMQTQQMI----EMLLDIRRTRNELD
.||| .   |. .|  .    |...|... | ..| | .. ...    .. .|...|| |..|||.|||      ..  ...     .. .    ... .
qyWple..eessae..f....gdlsvsnveveeeedykvrvleiknvkteesrkvthfqflsWPdyGvPssaaslldvlekvrekqalavkelgdewkgh

RAESPLIVHCSAGIGRTGTMIALDHAMCALDMGVKVDVLSIVADIREDRMAMVQHVVQYRYLYQAVVEYAERL
  . |..||||||||||||.|.|| ..  |..  .|||   |  .|. |  ..|   || . |.||.||| .|
psgPPivvhcsaGiGrtGtfitldiclsrleevgtvdvvetvkllrtqrafsiqtpeqyefcylavleyalel
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 726-1000 2.5e-50 166.4 In-house 37-283 (305) alignment 
Range on Protein: 726-1000
Range on HMM: 37-283/305.0
ESDLPDYARGPRLNRFRDILPNPVTRVRLEPLEVDHTLEYINANYVRdpsapcdnkpallgfGGRRAKEYVAAQAPKDTGLFNFWRMIVHVQARCIAMTT
  |.       . ||...| . .  |..| . | ..  .||||.||                | .| |.|..||.| .. . .|||.||... . | | |
sidvgkkeankaknrlkeitlldddriiltekeslddsdyinasyvd...............gykrkkkyivaqgPlkntvadfWrliveekvstivmlt

GLVEGGKNKCSRYWPATIyaetKEELVYgprdGKIHVRTMLVTKMEGYIKTNIQVLY---QGSTRNLVHFWFTAWPDHGVPTRpdgsmqTQQMIEMLLDI
.||||||.|| .||| ..    .|.  .    |...|     .....||. ....     .  .|..... .| |||||||.       .  ..... ..
klveggkdkCrqYWpesk....tekkef....gefsvelksektasdyieRklkisiededkesrtvlqyqltdWPdhGvpqf......atsllslikrv

RRTRNEldRAESPLIVHCSAGIGRTGTMIALDHAMCALDMGVKVDVLSIVADIREDRMAMVQHVVQYRYLYQAVVEYA
......    . ||.||||||.||||. ||.| |.  |     |||  ..  .|. || |||   || .|..|. |. 
qkdqkk..dkgvpllVhCsagvgRtGvfiavdialerlkkEevvdvfevlkqlRskrmkmvqtldqYvflhdaldeli
subfamily_PTPN13_pd Subfamily PTPN13 737-1002 3.1e-50 165.9 In-house 39-271 (273) alignment 
Range on Protein: 737-1002
Range on HMM: 39-271/273.0
RLNRFRDILPNPVTRVRLEPLEVdhtleYINANYVRDPSapcdnkpallgfgGRRAKEYVAAQAPKDTGLFNFWRMIVHVQARCIAMTTGLVEGGKNKCS
. ||.|..||   |||.|.         ||||.... |              |    ||.|.| |  .   .||.|.   .|. ||| |  .|.|| || 
dknryrnvlPydetrvklgdegg.....yinaslikvpv.............gkdeyeyiacqGPlPetvkdfwqmvweqkaeviamvtlekekgkvkch

RYWPATIYAETKeelVYgprdGKIHVRTMLVTKMEGYIKTNIQVLY--QGSTRNLVHFWFTAWPDHGVPTRPdgsmqtQQMIEMLLDIRRTRNeldrAES
|||| .   ..|   |.    ....|. . |.|..|.   ...|     | .|...|. |..|||||||. .      .......  .|| ..     ..
rywPesknkklk...vs....nrlevellkvqkldgfvvralavkdsesgesrevahlnfvkwPdhgvPssa......aellqfvaevrrlqt....dag

PLIVHCSAGIGRTGTMIALDHAMCALDMGVKVDVLSIVADIREDRMAMVQHVVQYRYLYQAVVEYAER
|..|||||||||.||.|..| ..  ..   ..||  || ..|| | ..||   || . |.|..|  ..
PivvhcsaGiGrsGtlitidvvlglierdkefdvkeivrklreqrqgvvqtkdqyifvykailevlks
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 736-1000 9.2e-48 158.0 In-house 57-290 (298) alignment 
Range on Protein: 736-1000
Range on HMM: 57-290/298.0
PRLNRFRDILPNPVTRVRLEPLEVDHTLEYINANYVRdpsapcdnkpallGFGGRRakEYVAAQAPKDTGLFNFWRMIVHVQARCIAMTTGLVEGGKNKC
 . ||. ||..   .||.||  . |.  .|||| ..              .. ||    ..|.|||  . . .||||... .. .| | | |.| .| |.
kkkNRyadiialdssRvvLekedadeesdYiNAsflh.............aykgrn..afiatqaPltetvedFWrmvteedigtiVmltnleeldktky

SRYWPATiyaeTKEElvYgprdGKIHVRTMLVTKMEGYIKTNIQVL--YQGSTRNLVHFWFTAWPDHGVPTrpdgsmQTQQMIEMLLDIRRtrNELDRAE
..||| .     ||.  |    |.|.|. .   ..  .|.....|    . ..|..... || |||.|||.      ... ....| ..|.  .. .  .
hkywPde....gket..y....geitvsllskeefadlivrklkvskkkeekerevrqlhftsWpdkgvpe......natsvldllrkvra..sqqqagn

SPLIVHCSAGIGRTGTMIALDHAMCALDMGVKVDVLSIVADIREDRMAMVQHVVQYRYLYQAVVEYA
.|.||.||||.||.|| ||.|  .  .    .|||. .|  .|..|...||   || ..|.|| |. 
kpvivqCsaGvgRsGtfiaidsvlervkkeqvvDvfqvvkvlRkkrpgavqteeqYvfiyeavleal
subfamily_PTPN14_pd Subfamily PTPN14 738-1001 1e-47 157.6 In-house 52-297 (300) alignment 
Range on Protein: 738-1001
Range on HMM: 52-297/300.0
LNRFRDILPNPVTRVRLEPLEVDhTLEYINANYVRDPSapcdnkpallgfgGRRAKEYVAAQAPKDTGLFNFWRMIVHVQARCIAMTTGLVEGGKNKCSR
 |||.|.||   .||.| | . . . .||||  .. .              | . ..|..||.| .. . .||.|.   . . |.| |   |.||.|. .
knrfkdvlPyednrvelsptken.stgyinassikvsv.............ggkersyivaqgPleltvqdfWqmvWeqgvqlivmlteeeedgkeksfk

YWPATiyAETKEELVYGprdgKIHVRTMLVTKMEGYIKTNIQVLY--QGSTRNLVHFWFTAWPDHGVPTRPDGSMQTQQMIEMLLDIRRTRNELDRAESP
|.| .   . |... .|    | .| | .... . .| | ... .   .  |...|. .| |||||||  ..| ..  .... .     . .|   .. |
yfPkl..eskkktvefg....kfkvttkfsedsdsvittglklkhlpskeertvwhlqytDWpdhgvPeDvkgflsyLeevqsvrrktnseveskeskPP

LIVHCSAGIGRTGTMIALDHAMCALDMGVKVDVLSIVADIREDRMAMVQHVVQYRYLYQAVVEYAE
..||||||.|||| .|  |  . .|. . ..|. ...| .|| || .|| . ||...|.....| .
vlvhCsaGvGrtGvlilsdlliatlehneeidikkvlarLreqrmllvqtlaqYkfvYkvlikylk
subfamily_Ptp69D_pd Subfamily Ptp69D 714-1018 3e-47 156.2 In-house 26-304 (307) alignment 
Range on Protein: 714-1018
Range on HMM: 26-304/307.0
QGYKELPRGET-HESDLPDYARGPRLNRFRDILPNPVTRVRLEPLEVDHTLEYINANYVRdpsapcdnkpallGFggRRAKEYVAAQAPKDTGLFNFWRM
. |..|.. |. ...   .       ||. || .   |||.|.... ... .||||....             |.  .  |...|||.| .. ...||||
keyekLeareidkstkvsekkenalknRyedikafDktRvkLkkingkedsdYinasfik.............gy..kekkkfiaaqdPveatigDfWRm

IVHVQARCIAMTTGLVEGGKNKCSRYWPATiyaetkEELVYGprdgKIHVRTMLVTKMEGYIKTNIQVLYQG-------STRNLVHFWFTAWPDHGVPTR
|   .   | | . | |  ..||..|||        .|  ||    .| |...   |.. ||. ...|  ..        .|..| . .|.|.|  ||  
iaeqevtlivmlsnlteknrkkcakYWpie......devqyg....dilvklvseekhsdyiiReldvskkkeesgevedsrkvvqyhytgWkDskvPev

PDGSMQtqqMIEMLLDIRRTRneldraESPLIVHCSAGIGRTGTMIALDHAMCALDMGVKVDVLSIVADIREDRMAMVQHVVQYRYLYQAVVEYAERLAA
. | ..   .||.. .. ..       .||..|||||| ||.|...|||  .  |    |||.  .| |.|..|  .||   || .||.|...| .   .
argllk...lieqvrelykln......rsPivvhCsaGvgrsgifvaldsllqqlkaedkvdifetvkdLrsqRnllvqsleqYvflyralldyssygdt

REQEEEAAQAYEQ
 |. .. ..|.|.
dedvddledaier
subfamily_PTPN23_pd Subfamily PTPN23 737-1005 6.5e-47 154.7 In-house 45-285 (288) alignment 
Range on Protein: 737-1005
Range on HMM: 45-285/288.0
RLNRFRDILPNPVTRVRLEplevDHTLEYINANYVRDPSAPCdnkPAllgfggrrakeYVAAQAPKDTGLFNFWRMIVHVQARCIAMTTGLVEGGKNKCS
  ||.|||||   .|| |.    ... .|||| .|.| |. |   |            ..|.|||... |  ||.|... ... | | .   | ||.|..
eknrsrdilPyDhnRvklr....gskDDYinAsfvkdlspgc...Pd...........fiatqaPlqstlnDFWlmvyeqkssviVmllskeelgkpkvd

RYWPAtiyaETKEELVYGPrdgkIHVRTMLVTKMEGYIKTNIQ--VLYQGSTRNLVHFWFTAWPDHGVPTRPDGSMQTQQMIEMLLDIRRTRNELdraes
||||.    .. |  ..|.    ..|    |...| ... ...  .| .  .....|  .|.||..|||  |.  .|  . .|  .. .. . .      
rYwPe....dkgetvkfgd....lsvtlksvretethvervlkletldadavksvshlqltsWpelGvPasPetllqfldevesayeavqrkskt.....

PLIVHCSAGIGRTGTMIALDHAMCALDMGVK-VDVLSIVADIREDRMAMVQHVVQYRYLYQAVVEYAERLAA
||.||||||.||||..  .  |. .|. |   .|.. .|  .||.|  |||.. |.. .|.||.|.|.|   
PlvvhCsaGvgRtgvfalvyaavrelekgnglldiiqvvsrlreqRrfmvqekeqlkfsyeavleaarrvld
subfamily_PTPRA_pd Subfamily PTPRA 738-999 4.9e-46 152.1 In-house 61-294 (330) alignment 
Range on Protein: 738-999
Range on HMM: 61-294/330.0
LNRFRDILPNPVTRVRLEPLEVDHTLEYINANYVRdpsapcdnkpallgfGGRRAKEYVAAQAPKDTGLFNFWRMIVHVQARCIAMTTGLVEGGKNKCSR
 ||. .|||.  .|| | ..|  .. .|||| ..                | .. ....||| ||.  . .|||||   ..  | | | | |  ..|| .
knrvvnilPydfsrvilsvkeGveesdyinasfid...............GykekdkfiaaqGPkeetvedfwrmiweqksativmltelkerkeekcaq

YWPAT---IYAETKEELVYGPRDGKIHVRTMLVTKMEGYIKtniqvlyQGSTRNLVHFWFTAWPDHGVPTRPDGsmqtqqMIEMLLDIRRTRNEldRAEs
|||      | . . |.       .. || .||...    .       . ..| .  | ||.||| |||. | |      |...|  ......    |. 
ywPdeGlvtyGnirvevedetvlvdytvrkflvqqlpdatr.......ekksrlvrqfhftswPdvGvPfepiG......mlkllkkvkklnqq..sag.

PLIVHCSAGIGRTGTMIALDHAMCALDMGVKVDVLSIVADIREDRMAMVQHVVQYRYLYQAVVEY
|..||||||.|||||.|.||  .  .    ||||  .|  .|  |  |||   || ..|... ||
pivvhcsaGvGrtGtfivldavlervkaerkvdvfefvkrlrlqrpqmvqtdeqyefiykvlley
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 739-1000 5.3e-46 151.8 In-house 47-276 (515) alignment 
Range on Protein: 739-1000
Range on HMM: 47-276/515.0
NRFRDILPNPVTRVRLEPLEVDHTLEYINANYVrdPSAPCDnkpallgfggrraKEYVAAQAPKDTGLFNFWRMIVHVQARCIAMTTGLVEGGKNKCSRY
||...|||   .||.|| .. .   .|.|| |.  ||  .|             | |.|.|.|... . .|||.... .   ||| | | || | ||..|
nryknilPydsvrvklevindnPhsdyfnasyi..psfdnd.............kayiasqgPnkasvddfWrlvlqenvttiamvtklkegdkikcgky

WPATIyAETkeeLvygpRDGKIHVRTMLVTKMEGYIKTNIQVLYQGSTRNLVHFWFTAWPDHGVPTRpdgsmqTQQMIEMlldIRRTRNELDRAESPLIV
||    ...   .    . |.|.| .. .    | || ...|| .  .| .  | || |||.||| .      |. .. .   |.  . . .. . |||.
WPdkp.gds...v....kfGsikvelvsleactggikrkltvlkgddsrtvtqfhfteWPdkGvpkh......tssllkl...ikevkadhgqythplii

HCSAGIGRTGTMIALDHAMCALDMGVKVDVLSIVADIREDRMAMVQHVVQYRYLYQAVVEYA
|||||.|||| .|..|  .     .  |||. .|  ||..|. .||   || ..|.|| |. 
hcsaGvGrtGvvisidsvvahakttrmvdvfnfvtnirqkrpylvqtqeqyafiygavledl
subfamily_PTPRK_pd Subfamily PTPRK 738-998 1.9e-44 146.7 In-house 46-275 (314) alignment 
Range on Protein: 738-998
Range on HMM: 46-275/314.0
LNRFRDILPNPVTRVRLEPLEVDHTLEYINANYVrdpsapcdnkpallgFGGRRAKEYVAAQAPKDTGLFNFWRMIVHVQARCIAMTTGLVEGGKNKCSR
 ||. |||.   .||.| ... |   .||||...                . .|.......| |..  . .|||.. . .. .| | | ||| |. ||..
knrsgdilaydrsrvflitidgdpssdyinaali...............dsykrpaafivtqgPlqetvkdfWrlvydencasivmltelvevgrvkClk

YWPA--TIYAETKEELVYGPRDGKIHVRTMLVTKmegyiktnIQVLYQgSTRNLVHFWFTAWPDHGVPTrpdgsmQTQQMIEMLLDIRRTRNEldrAESP
|||   ..| . | |||    . .. ||.. |.|        ..  ..  .| . .| |..||||.||.      . . .....  .  ...|    . .
yWPedtevygdikvelvetellaelvvrifrvek........largqe.eirevrqfqflgWpdhdvPv......satgllklvrrvkksqee...eaGr

LIVHCSAGIGRTGTMIALDHAMCALDMGVKVDVLSIVADIREDRMAMVQHVVQYRYLYQAVVE
..|||||| ||||| ||.|  .  ..    |||  .| ..|. .. ||.   ||...|....|
ivvhCsaGaGrtGtfiaidivldmieregvvdvfnavktlrsrkvnmveteeqykfiydvile
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 739-998 4.7e-44 146.0 In-house 65-289 (319) alignment 
Range on Protein: 739-998
Range on HMM: 65-289/319.0
NRFRDILPNPVTRVRLEPLEVDHTLEYINANYVRdpsapcdnkpallgfGGRRAKEYVAAQAPKDTGLFNFWRMIVHVQARCIAMTTglveggKNKCSRY
||. .||.   ..|.||.|.     .|||| .|                | .| . |.||| |.|  | .|||||   ..  | . |      |.|||.|
nriinilafdknvvklerliGeefsdyinasfvt...............GyqrkdkyiaaqGPldntladfWrmiweyncstivllt......kdkcsqy

WPATIYAetKEelvygprdGKIHVRTMLVTKMEGYIKTNIQVLYQG---STRNLVHFWFTAWPDHGVPTRPDGSMQtqqMIEmllDIRRTRNElDRAESP
||  |    ||        .. .|.  .|.. . |.  .|..  .|     |..  | |  |||.|||  |   |.   ...    .|  ..   . . .
wplkivi..ke........erfkvkvdsveetaeyvvrdielsedgkekdirkitqfhflGwpdvGvpdypsdlmr...lvk...kvrhltsk.enhran

LIVHCSAGIGRTGTMIALDHAMCALDMGVKVDVLSIVADIREDRMAMVQHVVQYRYLYQAVVE
..||||||.||||. |.||  .  ..   .|||  .| |.|..|  .||..||| ..| |..|
ivvhcsaGvGrtGvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalle
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 739-1000 1.6e-43 144.0 In-house 55-284 (297) alignment 
Range on Protein: 739-1000
Range on HMM: 55-284/297.0
NRFRDILPNPVTRVRLEPLEVDHTLEYINANYVRdpsapcD--NkpallgfggrrakEYVAAQAPKDTGLFNFWRMIVHVQARCIAMTTGLVEGGKnKCS
.|...|||  . ||.|. .. |   .|.|| .|.         .             .... | |... . .||.|... |.  |.| . . |. | || 
sRYkniLPydssRvkLaivnddpdsDyvnasfvk......gnkh.............rlittqmPmkatvadfWamvldeqvstivmlnddnerdk.kca

RYWPATIYAEtkeelvygprDGKIHVRTMLVTKMEGYIKTNIQVLYQG--STRNLVHFWFTAWPDHGVPTRPdgsmQTQQMIEMLLDIRRTRNelDRAES
|||. .  ..           |.. | .. |.. ||.|| ...|  .   ..| .  . |. |||. |. .     ......... ..| . .  ..||.
ryWsdkgvtt..........fGdvsvvllsvsereGfikrelevtkgkakarrvvkqyqfveWPdkaverkd....sassllklisevrkdfs..qnaeg

PLIVHCSAGIGRTGTMIALDHAMCALDMGVKVDVLSIVADIREDRMAMVQHVVQYRYLYQAVVEYA
||.|||.||.|||| ....|  ..      .||.. .|  .|..|. .||   ||...|.||.|. 
PllvhclaGvGrtgvlltidsvvaeakrekevdifglvkklrqerpylvqtkeqykfvyvavleal
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 739-998 2.1e-43 143.8 In-house 29-253 (284) alignment 
Range on Protein: 739-998
Range on HMM: 29-253/284.0
NRFRDILPNPVTRVRLEPLEVDHTLEYINANYVRdpsapcdnkpallgfGGRRAKEYVAAQAPKDTGLFNFWRMIVHVQARCIAMTTglveggKNKCSRY
||. .||.   ..|.||.|      .|||| ..                | .| . |.|.| |.|  | .|||||   ..  | . |      |.|||.|
nrighilafdknvvklerliGeefsdyinasfit...............GyqrkdkyiatqGPldntladfWrmiweyncstivllt......kdkcsqy

WPATIYAetKEelvygprdGKIHVRTMLVTKMEGYIKTNIQVLYQG---STRNLVHFWFTAWPDHGVPTRPDGSMQtqqMIEmllDIRRTRNElDRAESP
||  |    ||        .. .|.  .|.. | |.  .|..  .|     |..  | |  |||.|||  |   |.   ...    .|  ..   . ...
wplkivi..ke........erfkvkvdsveeseeyvvrdielsedgkekdirkirqfhflgwpdvgvpdypsdlmr...lvk...kvrhltsk.enhran

LIVHCSAGIGRTGTMIALDHAMCALDMGVKVDVLSIVADIREDRMAMVQHVVQYRYLYQAVVE
..||||||.||||..|.||  .  ..   .|||  .| |.|..|  .||..||| ..| |..|
ivvhcsagvgrtgvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalle
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 736-1000 8.9e-43 141.3 In-house 45-277 (315) alignment 
Range on Protein: 736-1000
Range on HMM: 45-277/315.0
PRLNRFRDILPNPVTRVRLEPLEVDHTLEYINANYVrdPSAPCDnkpallgfggrraKEYVAAQAPKDTGLFNFWRMIVHVQARCIAMTTGLVEGGKNKC
 . ||...|||   .||.|| .. .   .|||| |.  .|  .|             | |.|.|.|... . .||||... ..  |.| | . || | ||
fkknryknilPldsarvkleviddsPdsdyinasyi..ksvddd.............kayiasqgPlkasvddfwrmvlqekvttivmvtkkqegdkikc

SRYWPATiyaetKEELVygpRDGKIHVRTMLVTKMEGYIKTNIQVLYQGSTRNLVHFWFTAWPDHGVPTRPDgsmqtqQMIEMlldIRRTRNELDRAESP
 .|||       | ..|   . |.|.| .. .    . .. .. .    ..|..  | || |||.||. .         ....   |.  . . .. | .
rqywPdr.....kadsv...efGsikvellsleadtdgvarklvtrkseesrtvtqfqftewPdkGvdkqts......sllkl...ikevkadngkkefs

LIVHCSAGIGRTGTMIALDHAMCALDMGVKVDVLSIVADIREDRMAMVQHVVQYRYLYQAVVEYA
|.||||||.|||| .|..|. .  .  .  |||. .|  .|..|. .||   .| ..|.|| |. 
llvhcsaGvGrtGvvisidevvaqikrtrsvdvfnfvknlrakrpylvqteeeyafiydavledl
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 739-1001 1.4e-41 137.3 In-house 13-243 (250) alignment 
Range on Protein: 739-1001
Range on HMM: 13-243/250.0
NRFRDILPNPVTRVRLEPLEVDHTLEYINANYVRdpsapcdnkpallGFGGRraKEYVAAQAPKDTGLFNFWRMIVHVQARCIAMTTGLVEGGKNkCSRY
||. ||..   .|| ||. . |.  .|||| ..              |. .|  | ..|.|.|  . . .||||... ..  | | | |.| .|. ...|
nryadiialdssrvvLekekgdkesdyinasflh.............gyder..kafiatqgPlqatiedfWrmvleeksgtivmLtnLkesekt.yhqy

WPAtiyaETKEElvYgprdGKIHVRTMLVTKMEGYIKTNIQVLYQGS--TRNLVHFWFTAWPDHGVPTrpdgsmQTQQMIEMLLDIRRTRNELDraESPL
||.    |. |.  |    |...|  .   ..  |.|.....  .     | .... |..||| |||       ... ..|.| ........ .  ..|.
wPv....ekaek..y....GdvtvsllskeefadytkrklklskakkaderivrqlhfvvWPdkgvPe......vatavLellkkvqasqqqag..naPv

IVHCSAGIGRTGTMIALDHAMCALDMGVKVDVLSIVADIREDRMAMVQHVVQYRYLYQAVVEYAE
||.||||.||.|. ||.|  .  |    .|||  ..  .|.||. .|.   || ..|... .. .
ivqCsaGvgrsGafiaidavlerlkkekvvdvfkvikvlrkdrphavesleqyvfvyeiilkald
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 714-998 6.6e-41 135.2 In-house 28-277 (315) alignment 
Range on Protein: 714-998
Range on HMM: 28-277/315.0
QGYKELPRGETHESDLPDYARGPRLNRFRDILPNPVTRVRLEPLEVDHTLEYINANYVRdpsapcdnkpallgfGGRRAKEYVAAQAPKDTGLFNFWRMI
| |. .| |. |  |        . ||. .|..   .||.|  ||.|   .|.|||..                |  . . |.|||.|. . . .|||..
qdyesipggqlhpldvakkienkqknryiniiaydksrvqlpllendphsdyvnanfid...............Gynkkrryiaaqgpnvasvkdfwrlv

VHVQARCIAMTTGLVEGGKNKCSRYWPATiyaetkeELVYGprdgKIHVRTMLVTKMEGYIKTNIQVLYQGSTRNLVHFWFTAWPDHGVPTrpdgsmQTQ
 . .   | | |.|||| |.|. .|||         ...||    || |  .   . . |    . | ..   |..| . .|.||| |||        | 
feedigkivmltnlvegekrkaekywpdk.......kviyG....kitvtrkseevnteytvrtlsvvfgdnirevvqlhytswpdmgvpk......yti

QMIEMlldIRRTRNELDRAESPLIVHCSAGIGRTGTMIALDHAMCALDMGVKVDVLSIVADIREDRMAMVQHVVQYRYLYQAVVE
 ....   ||. .   . . ....||||||.|||||.|.||  .  ...   .||  ..  .|. |. ||| . ||...|.|..|
plmnl...irtvkqhhtnsvgaivvhcsaGvGrtGtfitldavldqaeaenaidvynfitgvrqnrikmvqvaeqyqfiydalle
subfamily_PTPRG_pd Subfamily PTPRG 738-1012 8.4e-41 134.8 In-house 50-296 (563) alignment 
Range on Protein: 738-1012
Range on HMM: 50-296/563.0
LNRFRDILPNPVTRVRLEPLE-VDHTLEYINANYVRdpsapcdnkpallgfGGRRAKEYVAAQAPKDTGLFNFWRMIVHVQARCIAMTTGLVEGGKNKCS
 ||  .|..   .||.|.||  ....|.||||||.                | ...|...|.| |  . .  |||||   ..  | | | ||| |..|| 
KnRylnivaydrsRvklsplpgkkkklDYinAnyid...............GyqkskafiatqgplkdtfddFWrmiWeqnvaiivmitnlvergrrkcd

RYWPAtIYAETKEELVYG-PRDGKIHVRTMLVTKMEGY-IKTNIQvlyQGSTRNLVHFWFTAWPDHGVPTRPdgsmqtqqmIEMLLDIRRTRNELDRAES
.|||.   .|| ..|     .  .. . |.   ...   .| . |   . . ..  .. .| |||||||. .         .  |  ...      ..  
vYWPk.desetygalqvtlieeevlalytvrtlviknlklkkkkq...cdteklvrqyhytkWPdhgvPehs.........lpvLifvkkssaankaeaG

PLIVHCSAGIGRTGTMIALDHAMCALDMGVKVDVLSIVADIREDRMAMVQHVVQYRYLYQAVVEYaerLAAREQEEEA
|..||||||.||||| |.||  .  .    .|.|. ..  ||  |  .||   || .|..|..|    .|..|.|  |
PivvHcsaGvgrtGtyivldtllkqiqqenavnvfgflkhiraqRnflvqteEqYiflhdallea...iasketella
0051429 (Phosphotyrosine protein) phosphatases II 765-1020 1.1e-40 135.3 In-house 6-244 (272) alignment 
Range on Protein: 765-1020
Range on HMM: 6-244/272.0
YINANYVRDPsapcdnkpallgFGGRRAKEYVAAQAPKDTGLFNFWRMiVHVQARCIAMTTGLVEGGKNKCSRYWP--ATIYAETKEELVYGPRDGKIHV
||||..|  .            ..  . . . ....| .    .|||.  . . ..| . ....| |..||.||||    ..  . .. .. .. |...|
yiNardvggy............grvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrv

RTMLVTKMEGYIKTNIQVL---YQGSTRNLVHFWFTAWPDHGVPTRPdgsmqTQQMIEMLLDirrtrneldraESPLIVHCSAGIGRTGTMIALDHAMCA
... .. .. || .....    . | .| . |...|.|||||||. .       ...|.|||           . |..||||||..||||..||.. .  
tllseellldyilrellltlllsagearevmhlhytdwpdhgvpqea.....llellellld...........ggpvlvHCsaGkdRTGtvvallllllg

LDMGVKVD--------VLSIVADIREDRMAMVQHVVQYRYLYQAVVEYAERLAAREQEeEAAQAYEQMR
... . ||        .. .|. .|. |...||.  ||..||.|..|....|.... |   ..|.....
vsletivddYlltnlyleeaveelraqrpgavqteeqylflyeallellrsllsvrae.yllaaldaid
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 739-1000 7.2e-40 132.1 In-house 52-288 (325) alignment 
Range on Protein: 739-1000
Range on HMM: 52-288/325.0
NRFRDILPNPVTRVRLEPLEVDHTLEYINANYVRDpsapcdnkpallgFggRRAKEYVAAQAPKDTGLFNFWRMIVHVQARCIAMTTgLVEGGKNKCSRY
|||.....   .|| || .. |   .||||.|.||             .  .. . ..|||||. . . ..||...  ..  . ..   ...||..|. |
nrfknvvaldksrvvletkkddpssdyinasylrd.............d..kkkdvflaaqaPltatindlWrlvldWrcsvvvvln.eldlgkdrcavy

WPATIyaetKEELVYGPrdgkIHVRTMLVTKMEGYIKT--NIQVLYQGSTRNLVHFWFTAWPDHGVPTRPDGSMQTQQMIEMLLDIRRTRnelDRAESPL
||  .     .   .|.    ..|. . . ..  |..   ...   .| || .  | . .|.| ||. ||   .   |... . .  ..     .| .|.
wpkem....gksktfGg....levklrtieeisdyvhrvldvkqvkkGetrsvkqfqlqswddmGvqkrpatlisilqlvkavservtan...tkastpi

IVHCSAGIGRTGTMIALDHAMCALDMGVKVDVLSIVADIREDRMAMVQHVVQYRYLYQAVVEYA
.||||||.||||..|.|  |.  .    .||..  |  .|.|| .||. | ||  .|.|.||. 
lvhcsaGvGrtGvfislysalakvieesrvdifgfvkklrkdrpsmvetvdqyiliyealveay
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 737-1003 9.5e-39 128.0 In-house 48-286 (290) alignment 
Range on Protein: 737-1003
Range on HMM: 48-286/290.0
RLNRFRDILPNPVTRVRLEPLE--VDHTLEYINANYVRDPSapcdnkpallgfggrRAKEYVAAQAPKDTGLFNFWRMIVHVQARCIAMTTGLVEGGKNK
.||||..|...   |. | |.    | | ||||| |. . .                .|.|.|.|.|    | .||..|.. .  .| | |  .| ||.|
llnRfanivvyddnritLrpisghkDCtneyinAcyikgyk...............ekkqyiatqgpvsntlvdFWkliwqekvtiivmltniieegkvk

CSRYWPATiyaETKEelvYGPrdgkIHVRTMLVTKMEGYIKTNIQVLYQGS---TRNLVHFWFTAWPDHGVPTRPDGSMqtqqmieMLLDiRRTRNELDR
|  |||..   .||.   ||.    .... .  .....||.....|  . |   ....... .|.|...|  | | ...       ...  ......  |
CqqYWpds...dtka...yge....fsikllneetlneyierklevknknsagakqsvtqyqitnwdstgkvtnpqtil.......lvie.emyktqrkr

AESPLIVHCSAGIGRTGTMIALDHAMCALDMGVKVDVLSIVADIREDRMAMVQHVVQYRYLYQAVVEYAERL
 . ...||||...||... .|.. ..    .   .||....   |  .. .|| |.||....| |..| ...
gntsivvHCSdtvgrsavfcaaattinkcktegvidvfqvlksqRiqkpgsvqtvqqyqgifqivltyldsf
subfamily_PTPN1_pd Subfamily PTPN1 737-1003 4.8e-38 125.5 In-house 34-274 (290) alignment 
Range on Protein: 737-1003
Range on HMM: 34-274/290.0
RLNRFRDILPNPVTRVRLEPLEVdhtlEYINANYVRDPSApcdnkpallgfggrrAKEYVAAQAPKDTGLFNFWRMIVHVQARCIAMTTGLVEGGKNKCS
 |||.||. |   .|..||  ..    .||||. |  . |                ..|. .| |       ||.|. . ..... |   .|| ...|| 
nlnryrdvspydhsrikleradn....dyinaslveleea...............krsyiltqGPlpntvdhfWqmvWeqkskavvmlnkvvekeqikca

RYWPATIYaetKEELVYgpRDGKIHVRTMLVTKMEGYIKTNIQV--LYQGSTRNLVHFWFTAWPDHGVPTRPDgsmqtqQMIEMLLDIRRTrNELDRAES
.|||       ..||..   | |..|. .   . . |.   ...  |    ||...|| .|.||| |||  |       .....| ..|..   | .   
qywPqgee...ekelll..edtklkvkliseerksyytvrllelenlktqetreilhfhyttwpdfgvpespa......aflkflfkvres.GslssdvG

PLIVHCSAGIGRTGTMIALDHAMCALDMGVK---VDVLSIVADIREDRMAMVQHVVQYRYLYQAVVEYAERL
| ..||||||||.||.. .|  .  ..   .   ||.   . ..|. |. ..|   | |. |.|..| |  .
pavihcsaGiGrsGtfclvdtclvliekkddlssvdikkvllelrkyrlGliqtadqlrfsylaileGakvi
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 738-1001 1.1e-36 121.3 In-house 50-279 (287) alignment 
Range on Protein: 738-1001
Range on HMM: 50-279/287.0
LNRFRDILPNPVTRVRLEplevDHTLEYINANYVRdpsapcdnkpallgfGGRRAKEYVAAQAPKDTGLFNFWRMIVHVQARCIAMTTGLVEGGKNKCSR
.||...||.    || |.    ..  .|||| ..                | . .|....|..|    . |||..| . .   | | . . |  ...| .
knRltqilvpdnyrvllk....gehpdyinavfid...............gykekkafiiaesPmfntarnfWkliddrnvtaivmlcqekendeevcyq

YWPATiyaetKEeLVYGPRdgkiHVRTMLVTKMEGYIKTNIQVLYQG---STRNLVHFWFTAWPDHGvptrpdgSMQTQQMIEMLLDiRRTRNELDRAES
||| .     |  .|.|.     ... .  ....|||. ...|  ..   ...... . .|.|...|        ....| | .... .. ...  |...
yWpee.....ks.vvlGey....niellneevnagyierklevknknkagdkqqvkqyqitnWdstg.......kvtepqtillvie.emyktqrkrgnt

PLIVHCSAGIGRTGTMIALDHAMCALDMGVKVDVLSIVADIREDRMAMVQHVVQYRYLYQAVVEYAE
...||||...||.....| . ..   .    .||....   |  .. .|| | ||......|.|| .
sivvhCsdtvGrsamfcaaattinkckteGviDvfqvlksqriqkpgsvqtveqykfindivleyld
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 737-997 1.2e-35 117.8 In-house 35-292 (297) alignment 
Range on Protein: 737-997
Range on HMM: 35-292/297.0
RLNRFRDILPNPVTRVRLepLEVDHTLEYINANYVRDPSAPCDNKpallgfggrrakeYVAAQAPKDTGLFNFWRMIVHVQARCIAMTTGLVEGGKNKCS
| ||.||||    |||.|  | |    .||||.||  |  . | |             |. || | .. . .||..... . | |.| . | |.|..|| 
rknryrdilatddtrvkl..lrviterdyinadyvvfpdeeadlk.............yilaqGplsatvddfwtlvaeqdvrvivmvaklqedGrdkca

RYWPATIYAETKEELVYgprdgKIHVRTMlVTKMEGYIKTNIQVLYQGSTRNLVHFWFTAWPDHGVPTRPDGSMQT--------------QQMIEM----
 ||| .     |   |        .. ..   . .  | |..|..|.  .| . |  | .|||||||.  .   .                 ..||    
pywpsvvqerlkagdvv.....veflsst.sdefdrviltelqliyrsesrvvrhvqflswpdhGvpsdledlvrfqaqvcscciavpmmlalvemftam

-LLDIRRTRNELDRAeSPLIVHCSAGIGRTGTMIALDHAMCALDMGVKVDVLSIVADIREDRMAMVQHVVQYRYLYQAVV
 .| .   | |  |   .|.||||||.||.| ..  |  .  |  .   || .|.  .|| |  .|| . |. .||.||.
vflqleslraemprn.ayllvhcsaGvGrsGvvvlsdvilaklrkkripdvaailsilreqrarlvqtleqfellydavl
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 734-1000 2.3e-35 116.9 In-house 32-266 (283) alignment 
Range on Protein: 734-1000
Range on HMM: 32-266/283.0
RGPRLNRFRDILPNPVTRVRLEPLEVdhtlEYINANYVRDpsapcdnkpallGFGGRRAKEYVAAQAPKDTGLFNFWRMIVHVQARCIAMTTGLVEGGKN
. .| ||...|.|  . ||.|...      .|||| ..                  .. |.|..||.| |    .||.|. . .. .| | | | |. . 
enkrknrnqeivpadqwrvelksesr....dyinavfipv............sksykqdkkyiiaqsPldrtvvdfWkmvfdekitaivmltklqedlri

KCSRYWPAtiyaETKEElvYGPRdgKIHVRTMlvTKMEGYIKTNIQVLYQGSTRN---LVHFWFTAWpdhgvptrpdGSMQTQQMIEMLLDIRRT-RNEL
|||.|||     .  |.  ||.    . .|    |  . .|. .. . ...|...   | |. .  |           ... | .|. |. . .   .  
kCsqyWPk....rGsed..yGef..tvtlrke..ttsnsfiikelllrvnssakstlllahyqvidW..........leygeqaiinslvkfnkvislqt

DRAESPLIVHCSAGIGRTGTMIALDHAMCALDMGVKVDVLSIVADIREDRMAMVQHVVQYRYLYQAVVEYA
.  ..|..||||.|||||...||.  ..  .     ||| ..|  .||.|| .||   ||. ....|.| |
eskkgPivvhCstgiGrtavfiaasasvkdaltesvvdvfavvkimreqrmmavqtldqyklvhelvleqa
0041856 (Phosphotyrosine protein) phosphatases II 738-1000 3.6e-34 113.3 In-house 4-171 (182) alignment 
Range on Protein: 738-1000
Range on HMM: 4-171/182.0
LNRFRDILPNPVTRvrleplevdhTLEYINANYVRdpsapcdnkpallgfGGRRAKEYVAAQAPKDTGLFNFWRMIVHVQARCIAMTTglveggknkCSR
.||..||||.. .|           | |||||...               |...|....|.|.| .  . .|.||. . . ..| . |         . .
knrysdilpydhsr..........dldyInanlyl...............gslpatrfiatqgpllstvadflrmlkelgittivnlt.........eel

YWPatiyaetkeelvygprdgkihvrtmlvtkmegyiktniqvlyQGSTRNLVHFWFTAWPDHGVPTrpdgsmqTQQMIEMLLDIRRtrneldrAESPLI
|||                                          .  .|. ...... |||||||.       ........ ....        . | .
ywp..........................................ellerlgiqylylpwpDhgvpd.......ldelldfieevle.......eggpvl

VHCSAGIGRTGTMIALDHAMCAldmgvKVDVLSIVADIREDRMAMVQHVVQYRYLYQAVVEYA
||||||.|||||..|..  ..      .|.. ..|. .|. |. ||..  ||..|..|. |. 
VHCsaGvgRtgtlvaaylmkkl.....gvsleeavklvrsrRpgmvitpnqyfflqlallell
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 738-1000 9e-34 111.5 In-house 41-277 (287) alignment 
Range on Protein: 738-1000
Range on HMM: 41-277/287.0
LNRFRDILPNPVTRVRLEpLEVDHTLEYINANYVrdpsaPcdnkpallGFggRRAKEYVAAQAPKDTGLFNFWRMIVHVQARCIAMTTGLVEGGKNKCSR
 ||. |.||   ||| |   | ..  .|||||||     .        ..  .. ....|||.|  . . .|||.... ..  ... |  || ...|| .
knryadvlPiddtrvlls.aegelGsdyinanyv.....a........sy..tddeafiaaqgPiaatvrdfwravletrsasvitmtreveearlkcyk

YWPatiyaETKEELVYGprDGKIHVRTMLVTKMEgYIKTNIQVLyQGSTRN--LVH-FWFTAWPDHGVPTRPDGSMQTQQMIEMLLDIRRTRNELdraeS
|||     | .  .  |     . .    . . | |    .... .  ||.  .|. . . .|||....    | ..    ..  ....|  .|      
ywP.....erevPmrvG..GysvvlldydikePe.ygvralrli.dletrearvvkqldllswPdkvlaPtavglirfvldvkqhielardasev....G

PLIVHCSAGIGRTGTMIALDHAMCALDMGVKVDVLSIVADIREDRMAMVQHVVQYRYLYQAVVEYA
||.||...||||.|...|.   .  |    .|||  .|. .|| | |.|| |||.|.||.|.| | 
PlvvhddvGiGrsGillatlvlvsrledlGrvdvaavvirlreyraalvqavvqlrllyealvtyy
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 790-1002 9.3e-34 111.8 In-house 79-279 (307) alignment 
Range on Protein: 790-1002
Range on HMM: 79-279/307.0
RRAKEYVAAQAPKDTGLFNFWRMIVHVQARCIAMTTGLVEGGKNKCSRYWPAtiyaETKEELVYGPRDGKIHVRTMLVTKM---EGYIK-TNIQVLYQGS
 . | ...|| |...  ..|| |..  .  .. |   ..| .| || .|||.    |  ..||.| .   | |  . . |.   | .|. |...| . . 
ikpkkficaqgplentqysfwamaiqekvesvimlckvielakikceqywpl....eegqklvfgeapntisvanlgakklapdedlinvttlkvdwaqk

TRNLVHFWFTAWPDHGVPTRpdgSMQTqqmIEMLLDIRRTRNeldraesPLIVHCSAGIGRTGTMIALDHAMCALDMGVKV-DVLSIVADIREDRMAMVQ
.| . |. .. |||.|||      . .   |..|  .|  .|       |..||||||.||.||..|.   .  .  |.   |.  .| ..|..|   .|
srtiqhlqwenwpdrgvpqi...nlta...inlleavrydtn.......pvvvhcsaGvGrsGtivaislvqdkmiaGinckdmkklveelrsqrhyaiq

HVVQYRYLYQAVVEYAER
  .|| ||.. ..||   
teaqylylhrvlleyfle
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 739-998 6.3e-33 108.9 In-house 52-277 (439) alignment 
Range on Protein: 739-998
Range on HMM: 52-277/439.0
NRFRDILPNPVTRVRL-EPLEVDHTlEYINANYVRdpsapcdnkpallgfGGRRAKEYVAAQAPKDTGLFNFWRMIVHVQARCIAMTTGLVEGGKnkcsr
||..|. .   ||| | |   | |.  ||||||..               |    | |.|.|.||.    .|||.... ..  | | | |||  |     
nrykdvgafdhtrvtlqeipgvphs.hyinanyik...............Gyyddklyiatqgpkkettddfwrlviekktvtivmltnlvesyk.....

YWPatiyaeTKEELVYGprdgKIHVRTMLVTKMEGYIKTNIQVLYQG----STRNLVHFWFTAWPDHGVPTrpdgsmQTQQMIEMLLDIRRTRNEldRAE
|||      ...| .||     | ||.    ..  |.   ..|. .       | ...| ..||||. ||.      |.  ....|  |  . ..  .  
ywp......sdaevcyg....diavrvdrnielpnyvirgfkvfnerdttekertvlqfhyiawpdknvpa......qashvldflrainsandk..eey

SPLIVHCSAGIGRTGTMIALDHAMCALDMGVKVDVLSIVADIREDRMAMVQHVVQYRYLYQAVVE
 |..||||||.|||||.|||| |.  | .  |||.  ||  .|..|  |||...|| ..|.||.|
gpvvvhcsagvGrtGtiialdialeqlklenkvdikgivkvlrkqrkqmvqalcqyvfiynavle
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 739-998 1.3e-31 104.6 In-house 11-238 (239) alignment 
Range on Protein: 739-998
Range on HMM: 11-238/239.0
NRFRDILPNPVTRVRLEPLEVDHTLEYINANYVRDpsapCDNKPallgfggrraKEYVAAQAPKDTGLFNFWRMIVHVQARCIAMTTGLVEGGKNKCSRY
||. .|.    .|| || |  |   .||||.|.||     |  |          | |.|.|    .   .||||. . .   | | |||.|| |.|| .|
nryanivtydhsrvvleklsndphsdyinasylrd....ydgsp..........kayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqy

WPATIYAETkeELVYGPRDGKIHVRTMLVTkmegYIKTniqVLYQGSTRNLVHFWFTAWPDHGVPtrpdgsmqtqQMIEMLLDI--RRTRNELDRAeSPL
|| .       .|    |  ..    .. |    .. .    . |   | . .. || |||.|||          |    .| .  . |.. |  |  | 
wpdstskyc..nlrvtlrktevfadyiirt....fvms...qvgqteeryvyqyhftvwpdkgvp..........qyatavlglrrkitkdslpga.rpw

IVHCSAGIGRTGTMIALDHAMCALDMGVKVDVLSIVADIREDRMAMVQHVVQYRYLYQAVVE
..|||||.||||... .|  .        ||..  |  |||||  |||   || ... ||.|
vihcsagvgrtgaflvidamlrqakkqktvdifnyvkairedrphmvqtseqyvfihlavle
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 716-999 1.5e-31 104.2 In-house 21-292 (301) alignment 
Range on Protein: 716-999
Range on HMM: 21-292/301.0
YKELPRGETHESDLPDYARGPRLNRFRDILPNPVTRVRLEPLEV--DHTLEYINANYVRdpsapcdnkpallgfGGRRAKEYVAAQAPKDTGLFNFWRMI
|||| .|| .....    .  .||||..| . .  |. |.| .    .. |||||.|.                | ...|...|||.| .  | .|||.|
ykelkegedksctvglseenkalnrfknitvyddnriilkpkpnldlcqreyinasyid...............gysekkkfiaaqgpmkktlvdfWrli

VHVQARCIAMTTGLVEGGKNKCSRYWPATIYAETKEELVYGPRDG-----KIHVRTMLVTKM----EGYIKTNIQVLYQGSTRNLVHFWFTAWPDHGVPT
.. .   | | |.| || |.|| .||| .   ....  .              .| . |.      .|||. ...|  . |..... .  | ||..||  
wqekpvsivmvtnlkegtkskceqywpnseaeseefgpftvtlvneqvyPdfvirqlnvkiqdgsnngyierkfkvksdksswdvlqlqvtdWpqdGvvr

RPDGSMQTqqmIEMLldIRRTRNeldRAESPLIVHCSAGIGRTGTMIALDHAMCALDMGVKVDVLSIVADIREDRMAMVQHVVQYRYLYQAVVEY
 |   .|    |.    | |..       .|..||||....|.|. .... ..        |||  ..  .|  .. .|.   ||  .|... .|
eprtvLqv...iddv..ihrqqk...igggpvvVHCSdtVsrsGvYcsvsiglEQckaegVVdvfqvtkavrrskpgaVtTLeqytsiydvidmy
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 739-998 1.7e-31 104.2 In-house 12-239 (239) alignment 
Range on Protein: 739-998
Range on HMM: 12-239/239.0
NRFRDILPNPVTRVRLEPLEVDHTLEYINANYVRDpsapCDNKPallgfggrraKEYVAAQAPKDTGLFNFWRMIVHVQARCIAMTTGLVEGGKNKCSRY
||. .|.    .|| || |  |   .||||.|.||     |  |          | |.|.|    .   .||||. . .   | | |||.|| |.|| .|
nryanivtydhsrvvleklsndphsdyinasylrd....ydgsp..........kayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqy

WPATIYAETkeELVYGPRDGKIHVRTMLVTkmegYIKTniqVLYQGSTRNLVHFWFTAWPDHGVPtrpdgsmqtqQMIEMLLDI--RRTRNELDRAeSPL
|| .       .|    |  ..    .. |    .. .    . |   | . .. || |||.|||          |    .| .  . |.. |  |  | 
wpdstskyc..nlrvtlrktevfadyiirt....fvms...qvgqteeryvyqyhftvwpdkgvp..........qyatavlglrrkitkdslpga.rpw

IVHCSAGIGRTGTMIALDHAMCALDMGVKVDVLSIVADIREDRMAMVQHVVQYRYLYQAVVE
..|||||.||||... .|  .        ||..  |  |||||  |||   || ... ||.|
vihcsagvgrtgaflvidamlrqakkqktvdifnyvkairedrphmvqtseqyvfihlavle
subfamily_PTPRN_pd Subfamily PTPRN 737-1000 3.9e-31 102.9 In-house 58-292 (297) alignment 
Range on Protein: 737-1000
Range on HMM: 58-292/297.0
RLNRFRDILPNPVTRVRLEPLEVDHTLEYINANYVRDpsapcdNKPallgfggrRAKEYVAAQAPKDTGLFNFWRMIVHVQARCIAMTTGLVEGGKNKCS
. || ...||   .||.|.    ... .||||  . |      . |        ||  |.|.|.|  . . .||.|. .  .  | . | | | | ..|.
kknrskavlpydhsrvklkeeasaeksdyinasaild......hdp........rapayiatqgplastvadfwqmvweqGvvvivnltrleeegvkqck

RYWPAT---IYAETKEELVygprDGKIHVRTMLVTKMegYIKtNIQvlyQGSTRNLVHFWFTAWPDHGVPTRPdgsmqtqqmiEMLLDIRRTRNELDRAE
|||| .   .|   . .||      .|     ||  .  |.| |.|   .  || .  | | .||..|||. .            ||. ||  |   |  
rywpdeGsevyhiyevhlv....sehiwcddylvrsf..ylk.nlq...tsetrtvtqfhflswpeegvPasa..........ksllefrrkvnksyrGr

-SPLIVHCSAGIGRTGTMIALDHAMCALDMGVK-VDVLSIVADIREDRMAMVQHVVQYRYLYQAVVEYA
 .|..||||.| ||||. |..|  .  |  ||| .|. . .  .|..|  .|.   |... ..||.|  
scpivvhcsdGaGrtGvyilidlvlnrllkGvkeidiaatlehlrdqrpglvktkdqfefaltavaeev
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 718-998 6.8e-31 102.0 In-house 28-234 (392) alignment 
Range on Protein: 718-998
Range on HMM: 28-234/392.0
ELPRGETHESDLPDYARGPRLNRFRDILPNPVTRVRLEPLEVDHTLEYINANYVrdPSAPCDnkpallgfggrraKEYVAAQAPKDTGLFNFWRMIVHVQ
.||  . ..          . ||...|||   .||.|| ..     .|.|| |.  ||  ..             | |.|.|.|. . | .||||. . .
dlpgpdiypqtvaqkeinlkknryknilpydsarvkleviddipdsdylnasyi..psfdne.............kayiasqgpnaaslddfwrmvfqen

ARCIAMTTGLVEGGknkcsrywpatiyaetkeelvygprdgkihvrtmlvtkmegyiktniqvlYQGSTRNLVHFWFTAWPDHGVPTRpdgsmqTQQMIE
.  ||| | | ||                                                      ..|    | || |||..|| .      |  ...
vttiamvtklkegd..................................................kgddartvaqfhftewPdkdvpkh......tssllk

MlldIRRTRNELDRAESPLIVHCSAGIGRTGTMIALDHAMCALDMGVKVDVLSIVADIREDRMAMVQHVVQYRYLYQAVVE
.   |.  . .  .   |||.|||||.|||| .|..|  ..       |||. .|..||. |  |||   || ..| ||.|
f...ikevkadfGqythpliihcsagvgrtgvvisidsvvahakktrmvdvfnfvtnirrkrpymvqtkeqyafiygavle
0036282 (Phosphotyrosine protein) phosphatases II 793-994 9e-31 102.3 In-house 17-164 (174) alignment 
Range on Protein: 793-994
Range on HMM: 17-164/174.0
KEYVAAQAPKDtglfnFWRMIVHVQARCIAMTTGLVEGGKNKCSRYWPAtiyaetkeelvygprdgkihvrtmlvtkmegyiktniqvLYQGSTRNLVHF
....| |.| .     ||.|. . . ... | . ..| |. || .|||                                        |..  .|. ...
prliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe.......................................lredlerlgiqy

WFTAWPDHGVPTRPDgsmqTQQMIEMLLDIRRTrneldRAESPLIVHCSAGIGRTGTMIALDHAMCALDmGVKVDVLSIVADIREDRMAMVQHVVQYRYL
... |||||||. .      ..... . ...         . |..||||||.|||||..|..  .. |     ||.|..|. .|  |. |||.  |||.|
lylpwpDhgvpdlsi....llefvkfveealse.....dpggpvlVHCsaGvgRtGtlvaaylmlrgll.eslvdaldlvrelRlqrpgmvqtpsQyrfl

YQ
|.
yy
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 781-998 1e-30 101.7 In-house 34-237 (237) alignment 
Range on Protein: 781-998
Range on HMM: 34-237/237.0
KPALLGFGGRrAKEYVAAQAPKDTGLFNFWRMIVHVQARCIAMTTGLVEGGKNKCSRYWPATIYAETKEELVY----GPRDGKIHVRTMLVTKMEgYIKt
   | || |   |.|.||| | ..   .||.|.   .   | | |||.|| . || .||| |   ..   |              ||..|..|    .| 
atylkgfdgt.pkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywpstdqpaaygvltvslkkkeefsdytvrslllskrl.tlk.

niqvlyqgSTRNLVHFWFTAWPDHGVPTRPDGSMQTQQMIemlldIRRTRNeLdRAESPLIVHCSAGIGRTGTMIALDHAMCALDMGVKVDVLSIVADIR
          | .  . ||.|||.||| .    .. .. |     | |..  .    .| |.|||||.|||| .. .|  .        ||.   |  | 
........evrlihqyqftswpdrgvpqqtaallrfrkni.....inrsph.v.sesgpwiihcsagvgrtgiflvidamlrqakekkvvdiynyvysie

EDRMAMVQHVVQYRYLYQAVVE
|||  ..|   || ...|...|
edrpyiiqtkdqyvfihqtile
0046846 (Phosphotyrosine protein) phosphatases II 757-1001 2.4e-30 101.0 In-house 6-174 (176) alignment 
Range on Protein: 757-1001
Range on HMM: 6-174/176.0
LEVDHTLEYINANYVRDPsapCdnkpallgfggrrakeYVAAQAPKDTGLFNFWRMIVHVQARCIAMTTGLVEGGKNKCSRYWPATIYAETkeelvygpr
|  |  | |||||..  .   .                ..| |.|    | .|..|. . . ... . | .|| |. || .|||    ..          
lgldldldyinanlilgs...r................piatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgi.........

dgkihvrtmlvtkmegyiktniqvlyqgstrnlvHFWFTAWPDHGVPTRpdgsMQTQQMIEMLLDIRRTRneldraeSPLIVHCSAGIGRTGTMIALDHA
                                  ..... |||||||.      . ....|.. . ..          | .||||||||||||..|..  
..................................qylhlpwpDhgvpdl....elllellefirealkeg.......gpvlVHCsaGigRtgtlvaayll

MCaldmGVKVDVLSIVADIREDRM-AMVQHVVQYRYLYQAVVEYAE
..    .  ..|. ..| .|| |.  .||.  |||.||... .. .
el....ekglsveealalvreqRplgavqtpeQyrflyefellllk
0049772 (Phosphotyrosine protein) phosphatases II 731-1003 2.9e-30 101.5 In-house 42-283 (314) alignment 
Range on Protein: 731-1003
Range on HMM: 42-283/314.0
DYARGPRLNRFRDILPNPvTRVRLEPLEVDHtLEYINANYVRDPsapcdnkpallgfggrraKEYVAAQAPKDTGLFNF----------WRMIV--HVQA
|. ...  ||. |||| . .||.|  |.|.    ||||.||. .                  . ..|.|.|.. ....|          |||..    . 
dlflnrdknryldilpad.nrvilpglpvsg.sdyinasyvdgf..................lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnv

RCIAM---------------------TTGLVEGGknkcsR-YWPATIYAETkeelvygprdgkihvrtmlvtkM-------EgyiktniqvlyqgsTRNL
| | |                      ..| ..|       ...|..                                                 .|. 
rdivmsrdevladelsrLdaAlgKtpllildgng.....neptaadlellk......................eelydpelf..............erlg

VHFWFTAWPDHGVPTRPDgsmqtqqmiemlldIRRTRNELD--RAESPLIVHCSAGIGRTGTMIALDHAMCALdmgvKVDVLSIVADIREDRM-----AM
.... . .||...|.  |              ...  . ..  ....|..|||.||.|||||.....  | .|    .|..  ...|.|. |.      .
ikylripvpDgsaplled..............fdeflefieeadkggpvlvHCkaGkgRtgtfvvaaylmkll....gvsleealedvrlkRpinpnpgf

VQHVVQYRYLYQAVVEYAERL
..   || . ..|. || ..|
ieqleqyefilealleylkfl
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 737-1000 3.1e-30 99.8 In-house 58-283 (290) alignment 
Range on Protein: 737-1000
Range on HMM: 58-283/290.0
RLNRFRDILPNPVTRVRLEpleVDHTLEYINANYVRdpsapcdnkpallgfgGRRAkEYVAAQAPKDTGLFNFWRMIVHVQARCIAMTTGLVEGGKNKCS
. ||..|.  | .||| |.     .  .|. ||||.                | .|  .. .| .     ...|||... ..  | |   |.| || ||.
kknrykdvvcndktrvilk...dGydGdyvhanyvk................Glka.mfiltqGalkdtvidiwrmvlqekvaaivmlceliedGkakce

RYWPATiyaeTKEELVYGprdgKIHVRTMLVTKMEGY-IKTNIQVL--YQGSTRNLVHFWFTAWPDHGVPTrpdgsmQTQQMIEMLLDIRrtrneldRAE
.|.| .      | | .|    .| |   . .. .   ||  . |    .|    | |.   .|||. |.        |  .. .|  .|       .| 
qyypek....eGevltfG....eitvlcseeddkdaniikktlsvrdkdsGkehklkhlkikswpdksval......stlallrtlrilr.......kas

SPLIVHCSAGIGRTGTMIALDHAMCALDMGVKVDVLSIVADIREDRMAMVQHVVQYRYLYQAVVEYA
 |..||||||||||||..|.. ..  |  | ..|.| .|  .|. |.. ||  .||  | ...... 
GpvvvhcsaGiGrtGtfvaievglqilldGkeldlldlvralrnsrlnsvqvdiqylalveilldlG
subfamily_CG7180_pd Subfamily CG7180 739-999 4.7e-30 99.2 In-house 46-289 (296) alignment 
Range on Protein: 739-999
Range on HMM: 46-289/296.0
NRFRDILPNPVTRVRLEPLEVDHTLEYINANYVRdpsapcdnkpallGFggRRAKEYVAAQAPKDTGLFNFWRMIVHVQARCIAMTTGLVEGGKnKCSRY
||  ...|   .|| || |. ... .|||| ||              .|   . |||.  .|||.  . .|||..   .. .. . |   .  | ..  |
nrdvkvvPyDynRvvLekldGeeksdYinavyvd.............sf..lkkkeyivteapkketvdefWrlvydeeisavvvLtktfdfak.mypsy

WPAT---IYAETKEELVYGPRDGKIHVRTMLVTKM-EGYIKTNIQVlyQGSTRNLVHFWFTAWPD-HGVPTRPDGSMQTQQMIEMLldirRTRNELDRAE
|| .    | |   |.|      ... ||. .||.     ... ||  .  || . .| .| |.  . ||    . ..  ......    | ... |  |
wpnkskeqygeifveiveekqyanlkirtfkltkkivalteqekqv..kaetRivklfqlteWeledkvPlstnalielrrrvrlw....rekvdedpee

SPLIVHCSAGIGRTGTMIALDHAMCALDMGVKVDVLSIVADIREDRMAMVQHVVQYRYLYQAVVEY
.|..|..| | .|.|  .|.| ..  ..   .|||   |  .|..|  .|. | .|.|.|. . |.
gPvvvvssdGasRsGvylaidanlelvekeeevdvFeavktlrrsRpqLvenveeYkyiYdvllea
0049260 (Phosphotyrosine protein) phosphatases II 792-994 5.9e-30 99.4 In-house 8-144 (152) alignment 
Range on Protein: 792-994
Range on HMM: 8-144/152.0
AKEYVAAQAPKDTGLFNFWRMIVHVQARCIAMTTGLVEGGKNKCSRYWpatiyaetkeelvygprdgkihvrtmlvtkmegyiktniqvlyqgstrnlvH
 .|..|.|.| .  | .||||. . ....| | | |.| || || .|.                                                   .
pfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi...................................................q

FWFTAWPDHGVPTRPDGSMQTQQMIEMLldirrtrneLDRAESPLIVHCSAGIGRTGTMIALDHAMcaldmgVKVDVLSIVADIREDRMAMVQHVVQYRY
. .. |||||||. ..  ..  ..|| |         . . . | .||||||.|||||..|..  .       .|... .|| .|| |. .|..  |.|.
ylhlpwpDhgvpdlsqlllflllfiekl.........aldkggpvlVHCsaGvgRtgtlvaaylml......lgvsleeavalvrekRpgavpnpgqlrf

LYQ
||.
lye
PTPc_DSPc_SM00012 890-997 2.5e-29 96.9 In-house 3-104 (105) alignment 
Range on Protein: 890-997
Range on HMM: 3-104/105.0
VHFWFTAWPDHGVPTRPdgsmqtQQMIEMLLDIRRTRNELDRaESPLIVHCSAGIGRTGTMIALDHAMCALDMG-VKVDVLSIVADIREDRMAMVQHVVQ
 |...|.|||||||...      . ..|.| .... .|. .. ..|..||||||.|||||..||| ... |. .  .||.. ||  .|. |. |||   |
khyhytgwpdhgvPees......dsilellravkknknkses.skpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeq

YRYLYQAVV
| .||.|. 
ylflyrall
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 738-1007 2.6e-28 93.6 In-house 51-294 (305) alignment 
Range on Protein: 738-1007
Range on HMM: 51-294/305.0
LNRFRDILPNPVTRVRLEPlevDHTLEYINANYVRDPSAPcdnkpallgfggrraKEYVAAQAPKDTGLFNFWRMIVHVQARCIAMTTGLVEGGKNKCSR
 ||..|.      ||.||.       ||| ||||  |. |               | .. .||| .    .|| | .  .   | |   |.| | .||. 
knrykdvgcldnnrvkleg...pwpheyihanyvstptnp...............krfictqaplektcadfwymclqdkveaifmlcnllekgakkcle

YWPAtiyaETKEELVYGPRDGKIHVRTMLVTKMEGY------I-KTNIQVLYQG-STRNLVHFWFTAWPDHGVPTRpDgsmqtQQMIEMLLDIRRTRnel
|...    . |..| .  .. || |.    ....        . .| . .   | ..|   |. .  ||| |||.  |     . ..|.| . | ..   
yfas....kdkdvlefeekgqkisvkfessvtlkfrkdakakvtetvlviegpgekarkvthyhwidwpdrgvpaa.d.....lailellekarpsk...

draeSPLIVHCSAGIGRTGTMIALDHAMCALDMGVKVD-VLSIVADIREDRMAMVQHVVQYRYLYQAVVEYAERLAARE
     |..|||||||||||... |.. .  |  | ...    |.  |||.|   .|   || ...| ...| ..    .
....gpivvhcsagigrtgsvvmleyildqllagqiiedtdkilqkireqrnnsiqtdaqylfvhqvilnyfrkkklld
0043147 (Phosphotyrosine protein) phosphatases II 791-994 2.7e-28 94.3 In-house 18-155 (172) alignment 
Range on Protein: 791-994
Range on HMM: 18-155/172.0
RAKEYVAAQAPKDTGLFNFWRMIVHVQARCIAMTTGLveggknkcsrywpatiyaetkeelvygprdgkihvrtmlvtkmegyiktniQVLYQGSTRNLV
  ....| |.| .  |  ||||. . . ..| . |.|                                                   ...... .|. .
ipdrfiatqgplrntladfwrmlkelgithivnltel...................................................lydpellerlgi

HFWFTAWPDHGVPtRPDGSMQTQQMIEMLLDIRRtrneldraESPLIVHCSAGIGRTGTMIALDHAMcaldmgVKVDVLSIVADIREDRMAMVQHVVQYR
..... |||||||  ..  ... . |. || ...        . | .||||||.|||||..|..  .       ..... .|| .|| |. .||.  |||
qylylpwpDhgvp.llellleflefidellalsp........ggpvlVHCsaGvgRtgtlvaaylml......lglsleeavalvrekRpgavqnpsqyr

YLYQ
.||.
flyy
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 769-999 1.1e-26 88.2 In-house 72-288 (305) alignment 
Range on Protein: 769-999
Range on HMM: 72-288/305.0
NYVRDPSaPCDNKP-ALLGFGGRRAKEYVAAQAPKDTGLFNFWRMIVHVQARCIAMTTGLVEGGKNKCSRYWPATIyaETKEELVYGPRDGKIHVRTMLV
  . .|| |.|      .|      | ...|| | |  . .|| |... .   | |    || || ||..||||.     | ||  |    ..     . 
vkldkps.psdyihanyvgcpmipekrficaqgpldqtidefwwmviqnkveqivmlcktvelgklkcaqywpaaq..geklelksgivvenvsgskpme

TKMEGYIkTNIQVLYQG-STRNLVHFWFTAWPDHGVPTRPDGSmqtqqmIEMLLDIRRTRneldraeSPLIVHCSAGIGRTGTMIALDHAMCALDMGVKV
   |  | | ... | |  .  . |. .| ||| |||     |      .|.|  || ..        |..||||||||||||..|... .  .    ..
rdaeiqi.tllnltysgdqkmsvrhlqwtewpdrgvppcklts......lellsairgsk.......vpivvhcsagigrtgtivaieyilekiaenkpc

D-VLSIVADIREDRMAMVQHVVQYRYLYQAVVEY
  .  .|  .|..|   .|  ||| .... ...|
ppmpelvkalrdqrafsiqndvqylfihrvmlny
subfamily_ptpA1_pd Subfamily ptpA1 737-962 2.4e-26 87.4 In-house 49-258 (418) alignment 
Range on Protein: 737-962
Range on HMM: 49-258/418.0
RLNRFRDILPNPVTRVRLEPLEVDHTLEYINANYVrdpsapcDnkpallgfgGRRAKEYVAAQAPKDTGLFNFWRMIVHVQARCIAMTTGLVEGGKNKCS
  ||. .|||   |||.|. ..     .||||||.       |         |   |.....| |    . .||||.   ..| | | .   |  . || 
sknrytnilpvnhtrvqlkkiqdkegsdyinanyi.......d.........gaypkqfictqgplpntiadfwrmvwenrcriivmlsresencrikcd

RYWPATIYAETKEelVYGPRD---GKIHVRTMLVT--KMEGYIKTNIQVLYQGSTRNLVHFWFTAWPDHGVPtrpDgsmQTQQMIEMLLDIRRTRNEL--
||||  |  |     .||  .   |   |  . |        |  ||.. ..| ||.. .. .  |||| .|   |   .|| . ..|  |   .|..  
rywpeqiggeqfs..iygngnevfgtysvelveviqdpereiitrnirltfegetrditqyqyegwpdhnip...d...htqpfrqllhsitnrqnqiip

-DRAESPLIVHCSAGIGRTGTMIALDHAMCALDM
    . |.|||||||.|||||. .    |  || 
ssdrnvpiivhcsagvgrtgtfctavimmkkldh
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 716-999 5.6e-25 83.0 In-house 25-270 (288) alignment 
Range on Protein: 716-999
Range on HMM: 25-270/288.0
YKELPRGEThESDLPDYARGPRLNRFRDILPNPVTRVRLEplevDHTLEYINANYVRdpsapcdnkpallgfGGRRAKEYVAAQAPKDTGLFNFWRMIVH
|.. | . . .     .   |  .|....    .|||.|.    | .  ||.|| |                 ..  .  . |||| .. . ..|.|...
yrdspneas.idiidsfianptrdryenlprcditrvkls....ddpdfyiaanvvs...............sakykrrlicaqaPlngtieelWkmlle

VQARCIAMTTGLVEGGKNKCSRYWPATIYAETKEELVygprdgkI---HVRTmlvTKMEGYIK-TNIQVLYQGSTRN-LVHFWFTAWPDHGVPtrpDGSM
 . . | | . |.| ||.|   |.|  .  ...   .            ..    . ..  .| . ...  .| ..  . .  .  |.|.|||   .  .
sdveyivmlcellekGkeksaeyfPsklGekarigrl.......ctvvkkkr...adidklvkvsllriskegeekvivkilhlleWdddgvP...enyl

QTQQMIEMLldirrtrnelDRAESPLIVHCSAGIGRTGTMIALDHAMCALDMGVKVDVLSIVADIREDRMAMVQHVVQYRYLYQAVVEY
   ...|.|             . |..||.|||.|||||.|    |. .| .   . . |..|  ||.|.  .|   || |... | |.
splrllevl..........kslqkPivvhssaGvGrtgtlililialeslrlddflgirsllaklreerfkaiqtemqylyvhrcvlee
subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 738-1000 8.9e-25 81.9 In-house 40-269 (281) alignment 
Range on Protein: 738-1000
Range on HMM: 40-269/281.0
LNRFRDILPNPVTRVRLEP-LEVDHTLEYINANYVRDPsapcdnkpaLLgfggrrAKEYVAAQAPKDTGLFNFWRMIVHVQARCIAMTTGLVEGGKNKCS
 ||. .|    ..||.|.  .    . .|| |||.| |         .|       . |. .| ||     .||||| . .. .| |   ..|  ..||.
knrylnipcldisrvqlkvkmpnknstdyihanyirsp.........fl......krgyiltqgpkketradfwrmiwqenttaivmlcqfletnrekca

RYWPATIYAETKeelvYgprdGKIHVRTMLVTKMEGYIKTNIQVLYQGSTRNLVHFWFTAWPDHGVPTrpdgSmqTQQMIEMLLDIRRtrneldRAeSPL
 |.|   ..  .    .     |. |     |  .  . | ... |.| || . |. .  |||  ||     |  .. |...|  ||       |. .| 
eyfprnahcclq....f....dklsvsyedstvnkslvttrlnlsyegetrlithwlwkewpdwqvpe....s..sevmlkilrkira......rs.tpp

IVHCSAGIGRTGTMIALDHAMCALDMGVK-VDVLSIVADIRE-DRMAMVQHVVQYRYLYQAVVEYA
..|||||.||.||..|.. |. ..   .   |.  ||. .|   | | || . ||  ... .... 
vihcsagvgrsgtlmaveialqsihshftlpdikqivshlrvtgraasvqtlqqymliwkvlldfg
0051082 (Phosphotyrosine protein) phosphatases II 764-996 1e-24 82.3 In-house 4-149 (151) alignment 
Range on Protein: 764-996
Range on HMM: 4-149/151.0
EYINANYVRDPsapcdnkpallgfggrrakeYVAAQAPKDtglfNFWRMIVHVQARCIAMTTGLVEGGknKCSRYWPATIyaetkeelvygprdgkihvr
 |||..|| .                     . . ..| .     |.... . . ..| . ....| |  .| .|.|..                     
dyinfsyvtgg....................lyrsggpla....dflellkelgiktivnlrseeerg..ycpeylpelg....................

tmlvtkmegyiktniqvlyqgstRNLVHFWFTAWPDHGVPTRPdgsMQTQQMIEMLLDirrtrneldRAESPLIVHCSAGIGRTGTMIALDHAMCAldmg
                       ....|.... |||.|.|. .    . ....|.|||           . |..||||||.|||||..||.  ..     
.......................ievlhipildwpdpglplsf...davleflellld.........kkngpvlvHCsaGkgRTGtlvalylmllg....

vkVDVLSIVADIREDRMAMVQHVVQYRYLYQAV
  |.. ......|. |. .||.  |......|.
..vsleealeeyrlkrpgvvqpnqqflfqlfal
subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 793-1007 2.7e-24 80.4 In-house 82-285 (312) alignment 
Range on Protein: 793-1007
Range on HMM: 82-285/312.0
KEYVAAQAPKDTGLFNFWRMIVHVQARCIAMTTGLVEGGKNKCSRYWPATI-YAETKEELVYGPRDGKIHVRTMLVTKMEGYIkTNIQVLYQGSTRNLVH
. .|..|.| .    .||.. . . . .| . .|.|| | .||..|    . . . ..  ||     .| .      |.   .  .. |   |   .| |
erfvctqgplentcthfwqlalslgstsiillcgfvedgsekcakyisdivgfvdledhrvyteycteieiggkskdkithrv.lkvvvkatgqesklnh

FWFTAWPDHGVPTRPDGSMQtqqmieMLLDIRrtrneldRAESPLIVHCSAGIGRTGTMIALDHAMCALDMGVKVDVLSIVADIREDRMAMVQHVVQYRY
. ...|||||.|   | ...      .|  ..       .   |.| |||||.|||||.. ..  ..||    | .|  .   .| ||   |. . || |
yqwaswpdhgmpdscdtalr......llsavk.......kdkkpviahcsagvgrtgtlaliesmiaalrhprkqnvkdsfvllrkdrarsvrvfpqyvy

LYQAVVEYAERL--AARE
  ..|.|.        |.
alrcvleflyskglykrn
0044763 (Phosphotyrosine protein) phosphatases II 748-996 1.4e-23 78.9 In-house 3-167 (178) alignment 
Range on Protein: 748-996
Range on HMM: 3-167/178.0
PVTRVRLEPLEVDHTLEYINANYVRDPsapcdnkpallgfggrrakEYVAAQAPkdtglFNFWRMIVHVQARCIAMTTGLVEGGKNKCSRYWPATIYaet
. ||| |..||   . .||||... .                     |.... |      ......     ..| . |. .|.|..|| .|||       
drtrvllsnleglersdyinaseilpg...................lylgslpp.....addlellkelgithivnlteelelgflkcdpywpeeag...

keelvygprdgkihvrtmlvtkmegyiktniqvlyqgstrnlVHFWFTAWPDHGVPTRPDGSMQTQQMIEMLLdirrtrnelDRAESPLIVHCSAGIGRT
                                          ... .. .||||||. ..  ... ..|| .|         |. ..| .||||||.||.
..........................................iqylhipipDhgvpdllehflefvefieeal.........dekggpvlVHCsaGvgRs

GTMIALDHAMCAldmgvKVDVLSIVADIREDRMaMVQHVVQYRYLYQAV
||..|..  ..      .... .... .|| |. .|..  |.|.||.  
gtlvaaylmkkl.....glsleeaielvrerRp.ivpnpgqlrqLyefe
subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 732-1000 6.8e-23 76.0 In-house 32-270 (285) alignment 
Range on Protein: 732-1000
Range on HMM: 32-270/285.0
YARGPRLNRFRDILPNPVTRVRLEplevDHTLEYINANYVRDPsapcdnkpallgfgGRRAKEYVAAQAPKDTGLFNFWRMIVHVQARCIAMTTGLVEGG
|   | |||. |.     ||| |.    .|  .|| |...| |              |.    |...| |    | .||.|| . .   . |   |.|||
yeanpdlnryadvrcieetrvvlk....nhdrdyihaswmrmp..............gkdqstyittqgplpetlsdfwhmiyqekiayvlmlctlfegg

KNKCSRYWPATIYAETKeelvYGPRdgKIHVRTMLVTKMEGYIKTNIQVLYQ----GSTRNLVHFWFTAWPDHGVPTrpdgsmQTQQMIEMLLDIRRtrn
 .||. |.|  .    |    .|    .| .       . | |  .. |.           . |     |||.  |       ... |||.   ...   
vekcalyypeklgevvk....fgky..eitlteckeeaiagtilnaltvintedasseplymnhvqvpwwpdqlape......darpmielykwvkk...

eLDRAESPLIVHCSAGIGRTGTMIALDHAMCALDMGVKVDVLSIVADIREDRMAMVQHVVQYRYLYQAVVEYA
 ..  | |. ||||||.||| |.. .|.|   .    ....| || ..|  |.  ||  .|. .||  ..|| 
.vnpkekpicvhcsagvgrtatfvgidyatirimenpniemldivremramrfqavqshmqflflyvvlmeyf
subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 736-1002 8.5e-22 72.1 In-house 53-292 (310) alignment 
Range on Protein: 736-1002
Range on HMM: 53-292/310.0
PRLNRFRDILPNPVTRVRLEpLEVDHTLEYINANYVRDpsapcdNkpaLLgfggrRaKEYVAAQAPKDTGLFNFWRMIVHVQARCIAMTTGLVEGGKNKC
   ||. |..    .||.|. ..     .|| ||||.       |    |     | . .. .| | .  . .|||||   .|  | .    .| |. ||
mhknrysdvvcldtsrvklk.idksryedyihanyvkt......n...yl.....r.stficsqgplqhtiidfwrmifqeraesilllckvgeegrpkc

SRYWPATIYAETKEEL---VYGPRDGKIHVRTMLVTKMEGYIKTNIQVLYQGSTR-NLVHfWfTAWPDHGVPtrpDGSMQTQQMiEMLLDIRrtrneldr
  |||.   .||   .    ..    .. .  . || .   .  . |       | .|.. |   ||| |||   |   .|     .| ..|        
vgywpslgvtetygcirvtnlsesseefeicnlavtfvpdnvpvdeqpanlkelrvslik.w.pnwpdrgvp...dekchtvpq.rllaqvr........

aESPLIVHCSAGIGRTGTMIALDHAMCALDMGVKVDVLSIVADIREDRMAMVQHVVQYRYLYQAVVEYAER
   | .||||||..|.....||. ..  || | |||.  ...... .|.  .|  .|| .. .  . .|  
.hgpcvvhcsagkdrlyvvvalklkidkldrglkvdaeevktellksraiciqtelqyliidrvriifarg
0048076 (Phosphotyrosine protein) phosphatases II 877-998 2.1e-21 71.5 In-house 35-141 (145) alignment 
Range on Protein: 877-998
Range on HMM: 35-141/145.0
NIQVLYQGSTRNLVHFWFTAWPDHGVPTRPDGSMQTQQMIemlldirrtrNELDRAESPLIVHCSAGIGRTGTMIALDHAMCaldmgVKVDVLSIVADIR
|.    .. .|. ...... |||||||. ..  ..  ..|          .|. ... | .||||||.|||||..|..  ..      .|.. .... .|
nltselellerlgiqylylpwpDhgvpdllellleflefi..........eealkeggpvlVHCsaGvgRtgtlvaaylmll.....lgvsleealelvr

EDRMAMVQHVVQYRYLYQAVVE
. |. .|... |.|.||... |
sqrpgavpnpgqlrflyefele
subfamily_CG42327_pd Subfamily CG42327 739-925 6.2e-21 69.4 In-house 32-193 (319) alignment 
Range on Protein: 739-925
Range on HMM: 32-193/319.0
NRFRDILPNPVTRVRLEPLEVDHTLEYINANYVRDPSA-PCdnkpallgfggrrakEYVAAQAPKDTGLFNFWRMIVHVQARCIAMTTGLVEGGKNKCSR
.|. ...| | ||| |.    |   ||..|.||| .   |.                |.|||.. .    .|||..   |.| |   | | | | ..|..
srvinvvPlPetrvvlqrigdddkdeyldasyvrGyddapn...............syiaaqvsledsssdfwrtvweqqsrvivqltdlselGikvcae

YWPATiyAETKEELVYGprdgKIHVRTMLVTKMEGYIK-T-NIQVLYQGSTRNLVHFWFtAWPDHGVPTRPdgsmqtQQMIEMLLDIRRT
|.|.   .  ... .||    .| |        . |.  |  .. . .  .|.| |.|.  |.. .||. .      . .| |||..| .
ylPtk..etldntslyG....dilvtlkgrevkdryaistlllkrvdkeesrelthywy.kwleaevPaee......aaliamllevrss
subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 792-992 5.7e-20 66.2 In-house 89-273 (301) alignment 
Range on Protein: 792-992
Range on HMM: 89-273/301.0
AKEYVAAQAPKDTGLFNFWRMIVHVQARCIAMTTGLVEGGKNKCSRYWPATIYaetkEELVYGPRDGKIHVRTMLVTKMegYIKTNIQVLY---QGSTRN
.. ..|.|.| .    .|| |.|. .   |.| .  ||  ..||. | | .|     |.|  |  . ||. . ... |    .| ...|     . .|| 
phrfiatqgPlkntsedfwamlvqydvekivmlgqkvekleekceeylpvkis....ekldigrfkikiknkelilnkk..iskrtlevedstgkfatrt

LVHFWFTAWPDHGVPtrpDGSMQTQQMIEMLldirrtrnelDRAESPLIVHCSAGIGRTGTMIALDHAMCALDMGVKVDVLSIVADIREDRMAMVQHVVQ
..|. .. |.|.|||    . ... ...|..           ..| |..|||||||||. ..|. .    ...   ....   ....||.|   ||.. |
vthyqysewtdrgvP...kshaelfdlmelv..........kksekPivvhcsaGiGrsvafigteylareveadptieltealkhlrehrwngvqtnsq

YRYL
  ..
lywm
0048179 (Phosphotyrosine protein) phosphatases II 881-994 1.2e-19 65.9 In-house 41-139 (144) alignment 
Range on Protein: 881-994
Range on HMM: 41-139/144.0
LYQGSTRNLVHFWFTAWPDHGVPTRPDGSMQTQQMIEMLldirrtrnelDRAESPLIVHCSAGIGRTGTMIALDHAMcaldmGVKVDVLSIVADIREDRM
 ..  .|. ...... |||||||. ..   .. ..|| .           . . | .||||||.|||||..|..  .       .... ...| .|. |.
epefleregiqylhlpwpDhgvpdllellleflefieea..........leeggpvlVHCsaGvgRtgtlvaaylmk.....klglsleealalvrsrrp

AMVQHVVQYRYLYQ
 .|..  |.|.|..
gavpnpgqlrfLle
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 889-1000 3.1e-18 60.6 In-house 217-344 (350) alignment 
Range on Protein: 889-1000
Range on HMM: 217-344/350.0
LVHFWFTAWPDHGVPTRPDGSMQTQQMIEMLLDIRRTRNELDRAE-SPLIVHCSAGIGRTGTMIALDHAMC---ALDM----GVKVDV--------LSIV
. .. .  |.| ..  .|   .|. .. . |.|   ... || |. ||..||||||.|||||...||. .     |..     .|.||          ||
vyqlqvknWkDlslllnPesilqalevkndliddlfaeshldnarsspilvhCsaGvGrtGtlvtlDsllsdfeilenltkesrkldvaaktrDlisiiv

ADIREDRMAMVQHVVQYRYLYQAVVEYA
  .|. |. ||| . |. ..|.|.  | 
nelrkqrismvqnldqfifiYeallfyf
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 881-1020 4.6e-17 56.5 In-house 83-214 (440) alignment 
Range on Protein: 881-1020
Range on HMM: 83-214/440.0
LYQGSTRNLVHFWFTAWPDHGVPTRpdgsmqTQQMIEMLLDIRRTRNEldRAESPLIVHCSAGIGRTGTMIALDHAMCALDMGVKVDVLSIVADIREDRM
.    .| | .. . .|||.|||        .  ...|. |.  ....   ...||.|||||| |||| .||.|  .       ..|..|..  .|..| 
ingiesrtlkqyhyqgwpdkgvpkf......agpvlkmiqdvnesqek..agngpllvhcsagagrtgviiavdsilreakrsdqidifsfinsmrnnrp

AMVQHVVQYRYLYQAVVEYAERLAAREQEEEAAQAYEQMR
 |||   || ....||.|      .   |.. ..  ||..
qmvqtpeqyafvheavlegllcgdtliledditerveqiq
subfamily_CG42327_pd Subfamily CG42327 932-1003 5.5e-17 56.4 In-house 246-318 (319) alignment 
Range on Protein: 932-1003
Range on HMM: 246-318/319.0
AESPLIVHCSAGIGRTGTMIALDHAMCALDMG-VKVDVLSIVADIREDRMAMVQHVVQYRYLYQAVVEYAERL
   ||.|||| |.||||..|| | |.  |.     ||.  .|  .|.||   |. . || ..|. . |||. |
sqGPlvvhcsdGvGrtGlviasdiairsleeskrsvdiPqlvssvrrdrasavltkeqyefiykvlseyakkl
subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 798-995 1.9e-16 54.4 In-house 96-283 (302) alignment 
Range on Protein: 798-995
Range on HMM: 96-283/302.0
AQAPKDTGLFNFWRMIVHVQARCIAMTTGLVEGGKNKCSRYWPATIyaetKEELVYG---PRDGKIHVRTMLVTKMEGYIKTNIQVLYQ----GSTRNLV
   ||   |  .| .| . .   ..  ...||....||. |.   .    ..|| .|    .  ...      |  ...   ....  .       . . 
pivpkkstlekhwalieqynvaivvqlcsfvedeekkcaeyysdkv....ggelkfgrytvktvsvktdleeftdkksfklytveiknekkkkkvkktvd

HFWFTAWPDHGVPTRPDGSMQTQQMIEMLldirrtrneldraESPLIVHCSAGIGRTGTMIALDHAMCALDMGVKVDVLSIVADIREDRMAMVQHVVQYR
 . |.|||||| |  .. ...  .  |                  ..||||||.|||||..|. . .         |.||||  .|. |   ||.  |  
ilafsawpdhGapkeaytaldilkfcesy.............kknvlvhcsaGvGrtGtlvaikyGiqlcskkkvtdllsivlpvrqcryGavqdeqqli

YLYQA
||   
ylllc
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 738-1003 4.1e-16 53.8 In-house 36-262 (267) alignment 
Range on Protein: 738-1003
Range on HMM: 36-262/267.0
LNRFRDILPNPVTRVRLEPLEVDhtleYINANYVRdpsapcdnkpallgfGGRRAKEYVAAQAPKDTGLFNFWRMIVHVQARCIAMttgLVEGGKNKCSR
 ||. | ||   ||| |   | .    |||| ||                | .. . ... | | .    .|. .| . .   | .   |   ....  .
rnrlddnlpyddtrvilrtkeee....yinasyve...............gyktknafivtqdplkntitdfltvihdqkvpvivl...ltkvftdnirl

YWPATIYAETKeelvYgpRdgKIHVRTMLVTKMEGYIKTNIQVLY-QGSTRNLVHFWFTAWpdhGVPTrpdgsmQTQQMIEMLLDIRrTRNELDRAESPL
.||  .    |    |  .   . |   |  . . |    ... . . |..|.. ...  |    . |      . .  .. |. |  ..|.|. .. ||
fwPPkmgqakk....y..q..dltvehslekeendyqiitlelkfknesahnvtlyyykkw...nint......nnkpylkplfgil.aknqlengnrPl

IVHCSAGIGRTGTMIALDHAMCALDMGVKVDVLSIVADIREDRMAMVQHVVQYRYLYQAVVEYAERL
.|.||.|.||.||.. .|  .  .     .|.   .  ||. |...|.   .| |... ..||||  
vvacsdGvGrsGtflvidsqleraktegvsdifdflrkirsqriglvdtkeryiyihellaeyaegr
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 739-847 4.2e-16 53.6 In-house 51-158 (350) alignment 
Range on Protein: 739-847
Range on HMM: 51-158/350.0
NRFRDILPNPVTRVRLE-----PLEVDHTL---EYINANYVRDPSAPCDNKPALlgfggrrakEYVAAQAPKDTGLFNFWRMIVHVQARCIAMTTGLVEG
||...|||   .||.|.     .  ..|.|   .||||||.. .    . .|            |.|.|||    . .|...|.. . . | . | .|| 
nrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdf.........kYiatqaPlpstvddfykvillnkvkvilsltsdvel

GKNKCSRYWPATIYAET
. .|| |||.   | . 
nlekcyrYWqegsyddi
subfamily_egg_pd Subfamily egg 791-1000 3.7e-15 50.4 In-house 81-270 (307) alignment 
Range on Protein: 791-1000
Range on HMM: 81-270/307.0
RAKEYVAAQAPKDTGLFNFWRMIVHVQARCIAMTTGLVEGgkNKCSRYWPATiyaeTKEELVYGPrdGKIHVRTMLVTKMEGYI--KTNIQVLYQGSTRN
   |.. ||||      .||||.   . . | | |  .|   ..|  ||| .     .. ||. |  | ... .. | .    .   |.....       
llnefilaqaplkntvddfwrmvfqeevqyivmltsrkes..erceyywpka....esdslvtvp..GslrienlkvdskadplfrvtklklvGgddeer

LVHFWFTAWpdhgvptrpdgsmQTQQMIEMLLDI-RRTRNeldrAESPLIVHCSAGIGRTGTMIALDHAMCALDMG--VKVDVLSIVADIREDRMAMVQH
 .  |   .             .    . . | . |. ||    .  | .|..  |. ...|..|.. |.. |  |  .|  ||  |  .|  |   |. 
flehwqgdv.............nnssdvysplrvlrklrn....lskpvvvqdilGvskaatlvaieiallsllrGpitkslvlravvflrlrrrlsves

VVQYRYLYQAVVEYA
|..| ..|. |. . 
vllylfvyrlvlfff
subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 793-994 9.7e-15 49.3 In-house 5-198 (199) alignment 
Range on Protein: 793-994
Range on HMM: 5-198/199.0
KEYVAAQAPKDTGLFNFWRMIVHVQARCIAMTTGLVEGGKNKCSRYWPATIYAETKeelvYgprdGKIHVRTMLVTKMEGYIKTNIQ----VLYQGSTRN
. |.|.| |    . .||.|.    .  | |        .   . |||.|  . .|    |    | . | |  .|    |  | .     .    |||.
rryiatqhplretmadfwqmvwetgsghivmvnddqknkeadypfywpttesgtgk....y....gslsvttktittkpdytitaliltnnttappstre

LVHFWFTAWPDHgvpTRPDGSMqtqqMIEMLLDIRRTRNELD-RAESPLIVHCSAGIGRTGTMIALDHAMCALDM--GVKVDVLSIVADIREDRMAMVQH
. |. ||.| ..   | |. ..    .. ...  |   .  .   ..|.||||| | | || ..|||  . . .      ||.. .   .|. |  ..  
ishyqftswkek...ttpnval....fvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiiss

VVQYRYLYQ
. .| ..||
lqhynfiyq
subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 793-994 1.1e-14 49.1 In-house 4-197 (198) alignment 
Range on Protein: 793-994
Range on HMM: 4-197/198.0
KEYVAAQAPKDTGLFNFWRMIVHVQARCIAMTTGLVEGGKNKCSRYWPATIYAETKeelvYgprdGKIHVRTMLVTKMEGYIKTNIQ----VLYQGSTRN
. |.|.| |    | .||.|.    .  | |        .   . |||.|  . .|    |    | . | |  .|    |  | .     .    |||.
rryiatqhplretladfwqmvwetgsghivmvnddqknkeadypfywpttesgtgk....y....gslsvttktittkpdytitaliltnnttappstre

LVHFWFTAWPDHgvpTRPDGSMqtqqMIEMLLDIRRTRNELD-RAESPLIVHCSAGIGRTGTMIALDHAMCALDM--GVKVDVLSIVADIREDRMAMVQH
. |. ||.| ..   | |. ..    .. ...  |   .  .   ..|.||||| | | || ..|||  . . .      ||.. .   .|. |  ..  
ishyqftswkek...ttpnval....fvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiiss

VVQYRYLYQ
. .| ..||
lqhynfiyq
subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 798-1008 3.2e-14 47.1 In-house 95-293 (302) alignment 
Range on Protein: 798-1008
Range on HMM: 95-293/302.0
AQAPKDTG---LFNFWRMIVHVQARCIAMTTGLVEGGKnKCSRYWPATiyaetKEELVYGprdGKIHVRTMLVTKMEGYI-KTNIQVLYQGSTRNLVH--
|| || .    . .||||. . .   . .  |  |  |   | ..| .      .. ..    ||. | .  | |.|.   .  | || .| .  ..   
aQlpkvdsedsveeFWrmvfqekivsvvilvgeeelkk.tlselfpkk.....sgdykey...gkmfvNnrkVekaeeektryviEvlPegcsnsvlanv

FWFTAWPDHGVPTRPDGSMQTQQMIemlldirrTRNELdRAESPLIVHCSAGIGRTGTMIALDHAMCALDMGVKVDVLSIVADIREDRMAMVQHVVQYRY
  .| |... ||..    ..| . .          ..   |......    |.|| |....|  |.. |. | .. .  ||. ||..| ..|. . ||  
yvltnWkqkkvpvkyaeliktaakv........fakki.kadentvivSknGaGRagafltlavaveklqkgkepnikeivksiRsqRpravdslkQyvs

LYQAVVEYAERLAAREQ
|| |.. |  .   ...
lyialllyikkkvtkpe
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 888-1000 4.7e-14 46.5 In-house 219-344 (349) alignment 
Range on Protein: 888-1000
Range on HMM: 219-344/349.0
NLVHFWFTAWPDHGVPTRPDGSMQTQQMIEMLLDIRRTRNELDRAES-PLIVHCSAGIGRTGTMIALDHAMCALDM----GVKVDVLSI--------VAD
 |. . .  |.| ..   |   .|. .. . |.|   .|. || ... .|.|||||| ||||... ||  .  | .     .|... ..        |  
ellqlqvknwldlslllnPisilqalevkndliddlfarlyldtdqlstllvhcsaGcGrtGvlvtldlllsileplqnesnkiklqallkDlisiivne

IREDRMAMVQHVVQYRYLYQAVVEYA
.|  |..||| . |.  .|.|...| 
lrkqrismvqnlaqfiaiyealLkyf
SH2 SH2 domain 1116-1197 7.4e-13 39.0 Pfam-A 1-77 (77) alignment 
Range on Protein: 1116-1197
Range on HMM: 1-77/77.0
WFRSNFTRAQVEDLLSG-TPPGTFVVRPSS-KKDHFALSLQTVRhkiaNMLIVPIAQPN-GkflyKLGASNDQSFSSVAELVEHY
|.  . .|...|.||    ..|||.||.|. |.....||. . .    ..  . | . . |    |.  .....|||..||||||
WyhgkisreeaerlLlegkkdGtFLvReSeskpGdytlsvvddg....kvkhyriqsleng....kyyitenekfsslqeLvehY
subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 807-1007 8.9e-13 42.9 In-house 42-226 (255) alignment 
Range on Protein: 807-1007
Range on HMM: 42-226/255.0
FNFWRMIVHVQARCIAMTTGLVEGGKNKCSRYWPAtiyaETKEELVYgpRdgKIHVRTMLvTKMEGYIKTNIQVLYQG---STRNLVHFWFTAWPDHGVP
 .|...||  ..  ..| . . | |..|||.|.|     |  | |..     .. | |   .  .  ..|   ... |    |... |. .. |...  |
dkfyqtivqtktevvvmlcdfaeegvekcssyfpl....ekdeklkl..a..dvnvtttk.ssadvvlrtleitstlgekkkthtvkhysykGWieknaP

TRPDgsmqtqqMIEMLLdiRRTRNEldraeSPLIVHCSAGIGRTGTMIALDHA----MCALDM--GVKVDVLSIVADIREDRMAMVQHVVQYRYLYQAVV
  .         |  .|  .  |.       ...||||.||||. ...  . .    . .||    |..| ||.. ..|. | . ..  .|  .    |.
elar.......eilnil..kvvrds.....ksvvvhCstGiGrsaafvlaelvyqkmirsldttetveldylslleelrskrkraihtPlqlafsilmvl

EYAerLAARE
..     . |
dlv..fpkge
subfamily_eak_pd Subfamily eak 793-1009 9.3e-11 35.7 In-house 93-314 (332) alignment 
Range on Protein: 793-1009
Range on HMM: 93-314/332.0
KEYVAAQAPKDTGLFNFWRMIVHVQARCIAMTTGLVEGGKNKCSRYWPAtiyaETKEELVYGPRDgkIHVRTMlvTKMEGYIKTNIQVLYQGSTRNLVHF
..|. . ..... .| ||.|..  .. .| .    || . .|  .|.|     .|.||| .|  |  .. .     | . .   ....     | .. |.
rkyiltGiasedkvfafwqmvleqkspaivqlledvelkleksdkyfpd....ktreelkfGild..verkef..vkrniletrllelskGnethrvlhy

WFTAWPDHGVPTRPDGSMQTQQMIEM-LLDIRRTRNE-----------LDRAESPlIVHCSAGIGRTGTMIALDHAMCALDMGVK--VDVLSIVADIRED
 .  | .  .|   |     . | |.  | .  ....              . .| |. .. |  |.|... .|  .  .|  .|    |  ..  ... 
kvfGwtettlpkyedflalrkvmkevGvlllivmksallsstlkkyihtppsfap.iiqsarGsaraGvfvvidllirlidnkkknlysvedlilkvksk

RMAMVQHVVQYRYLYQAVVEYAERLAAREQE
|.  |    |. ..|..|..|  |   | ..
rihsvlvalqhsfiyeivldyllrrnnrlrd
subfamily_hpo-7_pd Subfamily hpo-7 808-1020 2.4e-10 34.7 In-house 49-244 (263) alignment 
Range on Protein: 808-1020
Range on HMM: 49-244/263.0
NFWRMIVHVQARCIAMTTGLVEGGKNKCSRYWPAtiyaETKEELVYgprdGKIHVRTMLVTKmEGYIKTNIQVLYQG---STRNLVHFWFTAWPDHGVPT
.|...||  ..  ..| .   | |..|||.|.|     |  | ...     .. | |  | . .  .||.  . . |    |... |. .. |...  |.
kfyqtivqtktevvvmLcDfneegvekcssyfPl....ekdekqkl....anvnvcttkvqs.dvllktlellstlgeKkkthtvkhysykgWiekndpe

RPdgsmqtqQMIEMLLDIRRTRneldraeSPLIVHCSAGIGRTGTMIALDHA----MCALDM--GVKVDVLSIVADIREDRMAMVQHVVQYRYLYQAVVE
 .       . |  .|.. |          .|.||||.||||.      . .    . .||    |..| ||.. ..|. | . ..  .|  .    |..
la.......reilnilkvarns.......kslvvhcstGiGrsaafsvaElvyqkmirsldttstveldylsLleelrssrkraihtPmqLafsilmvLd

YAERLAAReqeEEAAQAYEQMR
.     |.   .|.   |...|
fvlnnfak...geleakyqeir
subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 794-1015 6.8e-10 33.6 In-house 72-277 (290) alignment 
Range on Protein: 794-1015
Range on HMM: 72-277/290.0
EyvaaQAPKDTGLFNFWRMIVHVQARCIAMTTGLVEGGKN----KCSRYWPATIYAETKeelvYGprdgKIHVRTMLVTKMEGYIKTNIQVLYQGSTR-N
        ..  ...|| |.   ... . |.    |  .|     |..| | ..  | |    ..     . |.     | .. .. .. | ...     
i....tekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCakYvpesvgeelk....fk....gltvkCkskekeddvetRelvvkfddeeeft

LVHFWFTAWPDHGVPTrpdgsmQTQQMIEMLldirrtrNELDRAESPLIVHCSAGIGRTGTMIALDHAMCALD-MGVKVDVLSIVADIREDRMAMVQHVV
. | ..  | .  |.       .|. .....       . .   ..| ||||  || |  .. |.. ..  .  .  .| . ... ..|. |  ....  
vtHsllkgWnklnvqe......dtktllsli.......qkvkasktpvivHcvdGiSrsAalaaiilgyQkiaetsgsvkledvlkalrkqralaitsal

QYRYLYQAVVEYAERLAAREQEEEAA---QA
.. .   ..| .| .   .  |||     .|
elafvdagivllaievldqfaeeetekkaka
SH2 SH2 domain 129-202 1.4e-09 28.5 Pfam-A 1-75 (77) alignment 
Range on Protein: 129-202
Range on HMM: 1-75/77.0
WYVGKISAAEAKIMLDT-EPCGAWLVRASA-EEHAYSLMVKDMRgDINNFLLTEEPKDGGICLGTSRFDRVDDLIR
||.|||| .||. .|.. .. |..||| |  ..  |.| |.| . .....   .. . . .. .  .|. ...|..
WyhgkisreeaerlLlegkkdGtFLvReSeskpGdytlsvvddg.kvkhyriqslengkyyitenekfsslqeLve
subfamily_Sponge-PTP-7_pd Subfamily Sponge-PTP-7 937-998 2.5e-09 31.4 In-house 2-63 (69) alignment 
Range on Protein: 937-998
Range on HMM: 2-63/69.0
IVHCSAGIGRTGTMIALDHAMCALDMGVKVDVLSIVADIREDRMAMVQHVVQYRYLYQAVVE
.||||.| |||||.||.   |  .     ||..  |  .|  |  ||   ..| ... |.||
vvhcssgtgrtgtfiaimvemarikseklvdifnnvqymrkcrpmmvmneieyifihdalve
subfamily_Sponge-PTP7_pd Subfamily Sponge-PTP7 937-998 1e-08 29.4 In-house 1-62 (69) alignment 
Range on Protein: 937-998
Range on HMM: 1-62/69.0
IVHCSAGIGRTGTMIALDHAMCALDMGVKVDVLSIVADIREDRMAMVQHVVQYRYLYQAVVE
.||||.| |||||.||.   |  .     ||..  |  .|  |  ||    .| ....|.||
vvhcssGtGrtGtfiaimvemarikseklvdifnnvqymrkcrpmmvmneneymfihdalve
subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 793-999 4.1e-08 27.2 In-house 83-278 (303) alignment 
Range on Protein: 793-999
Range on HMM: 83-278/303.0
KEYVAAQAPKDTGLFNFWRMIVHVQARCIAMTtgLVEGGKNKcsrYWPATIYAETKEELVYGPRDgkIHVRT-MLVTKMEGYIKTNIQVlYQGSTRNLVH
|  . .| |      .||.||.. . .|. .   | ..  .|   .   ... . .. | .  |   | |     |  ..|.    . |  .|. . ..|
kkailtqlplshtaadfwqmiieqkvkcvlll..ltdseydk...lggdsvfprnqdflkfeers..irvgefkrvelgdgwvlkvlsv.sngdyksflh

F-WFTAWPDHGVPTrpDGSMQTQQMIEMLLDIRRTRNEldraESPLIVHCSAGIGRTGTMIALDHAMCALDM-GVKVDVLSIVADIREDRMAMVQHVVQY
   . |||   .|.  ||| .  . |  |  . |   .     .| .    .| ||.||.  .. |  .|      .|..  .  .|. |.  || . |.
vhhykawphnsips..dgspkfvkqiwqlqsvlrkysd....stptvymslsgcgragtfalfetahlslhseqasldlvkclenvrngrlhavqnlsqf

RYLYQAVVEY
 ..|  . |.
svvytllaeh
0038934 (Phosphotyrosine protein) phosphatases II 896-998 1.4e-07 26.9 In-house 86-175 (194) alignment 
Range on Protein: 896-998
Range on HMM: 86-175/194.0
AWPDHGVPTRPDGSMQTQQMIEMLLdirrtrnElDRAESPLIVHCSAGIGRTGTMIAldhamCALDMGVKVDVLSIVADIREDRMAMVQHVVQYRYLYQA
 .||.|..   .  ..  ....  |       . . ..    ||| ||.|||||..|     ..| .  . ..   .| .|| |  ..... ....|.. 
pfpddgtvPsleillrfldlvdefl.......n.edpggvvaVHCkaGlgRtGtlva.....aYLiyrlgmsaeeAialfrekRpgaipnqdyleallkr

VVE
. |
yke
SH2 SH2 domain 417-491 3.9e-07 20.7 Pfam-A 1-75 (77) alignment 
Range on Protein: 417-491
Range on HMM: 1-75/77.0
WYAGRVSRQAAAAVILQspNVRPGDFFFHQHPLEENVFYLTVNDHDRAAQYKIARNSAG--YVFGPKTFLTLQRLLE
|| | .||. |   .|.  . ..|.|   .   ... . |.| | ..  .|.| ..  |  |... ..| .|| |.|
WyhgkisreeaerlLle..gkkdGtFLvReSeskpGdytlsvvddgkvkhyriqslengkyyitenekfsslqeLve
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 764-847 8e-07 22.7 In-house 91-161 (349) alignment 
Range on Protein: 764-847
Range on HMM: 91-161/349.0
EYINANYVRDPSAPCDNkpallgfggrrakEYVAAQAPKDTGLFNFWRMIVHVQARCIAMTTGLVEGGKNKCSRYWPATIYAET
.||||||.. .    ..              |.| |||  . . .|...|.  . . .   .   | . .|| .||    |.. 
dyinanylkltrisvek.............kyiatqaPlPstvddfykvillngvklvlsLnddkelslekcdiywqelsysni
subfamily_PTEN_pd Subfamily PTEN 936-993 5.4e-06 21.5 In-house 117-173 (184) alignment 
Range on Protein: 936-993
Range on HMM: 117-173/184.0
LIVHCSAGIGRTGTMIALdHAMCALDMGVKVDVLSIVADIREDRMAMVQHVVQYRYLY
 .||| || ||||..|.  . . .| .  . ..|.. | .|      |.   | ||..
vvvHCkaGkGRtGvliva.yllkslllekaeealelfaeaRtknkkgvtiPsqrRYve
subfamily_CDC14_pd Subfamily CDC14 907-953 7.9e-06 19.9 In-house 243-283 (328) alignment 
Range on Protein: 907-953
Range on HMM: 243-283/328.0
DGSMQTQQMIEMLLDIrrtrneLDRAESPLIVHCSAGIGRTGTMIAL
|||. ...... .|.|      ...||  ..||| ||.|||||.|| 
DGstPsdaivkkflei......aekaeGaiavhCkaGLGrtGtLiac