Gene MbrePTP-sf4-1 in Monosiga brevicollis

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily MbrePTP-sf4
Protein sequence
ID Type Fasta BLAST phosphatome Note
MbreP050_AA protein Get Run
MbreP050_AA_4336-4609 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 4338-4610 3e-148 487.5 In-house 1-297 (297) alignment 
Range on Protein: 4338-4610
Range on HMM: 1-297/297.0
HLTEQRKEAANTYDSIFRERQGGSFSSSRRNST--KNRYTDILAYDDTRVKLRRGITGSDYINANYVTFPNEEAPFYFICAQGPTSQTVDDHWQLIWEND
.|.|.|||.....|....|..|.||||..|||.  ||||.||||.|||||||.|.||..|||||.||.||.|||....|.||||.|.||||.|.|..|.|
rlredrkeleaekdllldeargesfssakrnsslrknryrdilatddtrvkllrviterdyinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqd

VRVIVMVAKLQEDGRSKCAPYWPSSDQGGLKTPSFVVEFVSQTSDDpYDRVILtTELTLIHRltNERRHVTHVQYLGWPDHGVP----DVDRF-------
|||||||||||||||.||||||||..|..||....||||.|.|||. .||||| |||.||.|  .|.|.|.|||.|.|||||||    |..||       
vrvivmvaklqedGrdkcapywpsvvqerlkagdvvveflsstsde.fdrvil.telqliyr..sesrvvrhvqflswpdhGvpsdledlvrfqaqvcsc

-------LALID--------QVESLRAAHPRNMYTLVHCSAGIGRTGVVVQTMAMLAILRRKRIPEAAAILRHLREQRARLVQTLQQYEFCFTAVLAKLK
       |||..        |.|||||..|||.|.|||||||.||.||||.....||.||.||||..||||..||||||||||||.|.|....|||.|||
ciavpmmlalvemftamvflqleslraemprnayllvhcsaGvGrsGvvvlsdvilaklrkkripdvaailsilreqrarlvqtleqfellydavlkklk

A
.
e
0050432 (Phosphotyrosine protein) phosphatases II 4361-4610 9.3e-77 253.7 In-house 61-301 (308) alignment 
Range on Protein: 4361-4610
Range on HMM: 61-301/308.0
SFSSSRRNSTKNRYTDILAYDDTRVKLrrGiTGSDYINANYVTFPNEEAPFYFICAQGPTSQTVDDHWQLIWENDVRVIVMVAKLQEDGRSKCAPYWPSS
|...  .| .||||.|||.|| .||||  .  |||||||.||....   |  ||..|||...||.|.|...||..||||||. ||.|.|| |||.|||..
svallpenkdkNrykdilpydhsRVkl..d.egsdYInAsyvdgyssklprkfIatqgPlpntvedFwrmvweqnvrvIvmLtklvengrekcaqYwple

DQ-GGLKTPSFVVEFVSQTSddpyDRVILTTELTLIHRLTNERRHVTHVQYLGWPDHGVPD-VDRFLALIDQVESLRaahpRNMYTLVHCSAGIGRTGVV
 . | |.   |.|...|...    .  . ...|.| .  ..| |.||| .|..|||||||. .. .|.....|.. .    ..  ..||||||.||||..
lgggsleygkftvtllseev....lddytvrtleltnlgdgesrtvthfhytnWpdhgvPpspeilldflelvrksl....pggpivVHCsaGvGRtGtf

VQTMAMLAILRRKRIPEAAAILRHLREQRARLVQTLQQYEFCFTAVLAKLKA
.    .|  |.... . .  ....|||||.  |||..||.|.. |.|  || 
ialdllleqlekeggvdvfeavkklReqRpgmvqtpeqylflyralleylkl
0036941 (Phosphotyrosine protein) phosphatases II 4362-4610 3.9e-74 244.9 In-house 33-279 (297) alignment 
Range on Protein: 4362-4610
Range on HMM: 33-279/297.0
FSSSRRNSTKNRYTDILAYDDTRVKLrRGiTGSDYINANYVTFPneEAPFYFICAQGPTSQTVDDHWQLIWENDVRVIVMVAKLQEDGRSKCAPYWPSSD
 ... .| .||||.|||.||.|||||  .  |||||||.||...  . .. ||..|||...||.|.|...||..|.||||. .| |.|| |||.|||.  
vallpenleknRykdilpydhtRVkl.dd.egsdYinAsyvdgy..dlkrkfIatqgPlpntvedFWrmvweqnvtvIvmltelvelgrekcaqywplee

QGGLKTPSFVVEFVSQTSDdpYDRVILTTELTLIHRLTNERRHVTHVQYLGWPDHGVPD-VDRFLALIDQVESLRAAHPRNMYTLVHCSAGIGRTGVVVQ
.. |.   |.|...| ...  ..  . ...|.. .  ..| |.||| .|.||||||||. .. .|..|..|.. ... |..  .|||||||.||.|... 
gesltygdftvtllsvevv..llddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfielvrkvlkllpsggpvlVHCsaGvgRsgtfia

TMAMLAILR---RKRIPEAAAILRHLREQRARLVQTLQQYEFCFTAVLAKLKA
   ||  |.   . . .    ....|||||.  ||||.||.|.  |.|  || 
adlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallellkk
0051299 (Phosphotyrosine protein) phosphatases II 4361-4606 5.4e-74 244.6 In-house 42-284 (288) alignment 
Range on Protein: 4361-4606
Range on HMM: 42-284/288.0
SFSSSRRNSTKNRYTDILAYDDTRVKLR--RGITGSDYINANYVTFPNEEAPfyFICAQGPTSQTVDDHWQLIWENDVRVIVMVAKLQEDGRSKCAPYWP
|...   | .||||.|||.||..||||.   |. |||||||.|....| .    ||..|||...||.|.|...||..||||||. ||.|.|| |||.|||
saallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyidgynlkrk..fIatqgPlpntvedFWrmvweqnvrvIvmltklvelgrekcaqYwp

SsdQGGLKTPSFVVEFVSQTSDDPYDRVILTTELTLIHRLTNERRHVTHVQYLGWPDHGVPD-VDRFLALIDQVESLRAahPRNMYTLVHCSAGIGRTGV
.  .| |.   ..|...| ...| |    |. . . ... ..| |.||| .|..|||||||| .. .|... .| . .|  ...  ..||||||.||||.
l..ggsltygditvtllseevlddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpdspellldflrlvrkala..sgggpvvVHCsaGvgRtgt

VVQTMAMLAILRRKRIPEAAAILRHLREQRARLVQTLQQYEFCFTAVLA
..    .|  |.... ...  ....|||||  .|||..||.|.. |.| 
fialdllleqlekeggvdvleavkrlreqRpgmvqtpeqyrfvyealle
0046845 (Phosphotyrosine protein) phosphatases II 4362-4610 8.2e-74 243.8 In-house 22-276 (284) alignment 
Range on Protein: 4362-4610
Range on HMM: 22-276/284.0
FSSSRRNSTKNRYTDILAYDDTRVKLRRGITG---SDYINANYVTFPNE---EAPFYFICAQGPTSQTVDDHWQLIWENDVRVIVMVAKLQEDGRSKCAP
..    | .||||.|||.||..||||..   .   ||||||.||....      .  ||..|||...||.|.|...||..||||||. .| |.|| |||.
vallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweqnvrvIVmltelvengrekcaq

YWPSSdQGGLKTPSFVVEFVSQTSddpyDRVILTTELTLIH-RLTNERRHVTHVQYLGWPDHGVP-DVDRFLALIDQVESLRAAHPRNMYTLVHCSAGIG
|||.. .. |.   | |...| .     .  . ...|.| .  .|.| |.||| .|..||||||| ... .|.....|..|. ..|..  ..||||||.|
Ywple.gevltygdftvtllseev....kddytvrtleltnlgytgesrtvthfhytswpdhgvppspedlleflrlvrellenlpgggpivVHCsaGvg

RTGVVVQTMAMLAILRRKR---IPEAAAILRHLREQRARLVQTLQQYEFCFTAVLAKLKA
|||...  . .|  |....    . .  ....|||||   ||||.||.|.. |.|  || 
RtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyealleylkl
0047943 (Phosphotyrosine protein) phosphatases II 4362-4606 3.4e-73 241.8 In-house 32-270 (273) alignment 
Range on Protein: 4362-4606
Range on HMM: 32-270/273.0
FSSSRRNSTKNRYTDILAYDDTRVKLrrGITGSDYINANYVTFPNEEAPfyFICAQGPTSQTVDDHWQLIWENDVRVIVMVAKLQEDGRSKCAPYWPSSD
...  .| .||||.|||.||..||||  |  |||||||.||...| .    ||..|||...||.|.|...||..||||||. .|.|.|| |||.|||.. 
vallpenkdknrykdilpydhsrvkl..gdggsdyinAsyvdgynlkrk..fiatqgPlpntvedfwrmvweqnvrviVmLtelvelgrekcaqYwpleg

QG-GLKTPSFVVEFVSQTSddpyDRVILTTELTLIHRLTNERRHVTHVQYLGWPDHGVP-DVDRFLALIDQVESLRAAHPRNMYTLVHCSAGIGRTGVVV
..  |.   | |...|...    .  . ...|.| .  |.| |.|||..|.|||||||| ... .| .|..|.. ..| |.|  ..||||||.||||...
gelsltygkftvtllseet....kddytvrtleltnlgtgesrtvthfhytgwpdhgvppslesllefielvrkalealpsngpvvVHCsaGvgRtgtfi

QTMAMLAILRRKRIPEAAAILRHLREQRARLVQTLQQYEFCFTAVLA
    .|  |.... . .  ....||.||   |||..||.|.  |.| 
aldllldqlekeggvdvleavkllrsqRpgmvqtpeqyrflyealle
DSPc_SM00195 4363-4607 2.9e-72 238.5 In-house 21-261 (263) alignment 
Range on Protein: 4363-4607
Range on HMM: 21-261/263.0
SSSRRNSTKNRYTDILAYDDTRVKLRRGI--TGSDYINANYVTFPneEAPFYFICAQGPTSQTVDDHWQLIWENDVRVIVMVAKLQEDGRSKCAPYWPSS
.   .|..||||..|| ||.||||| .    .|||||||||....  . .  .|..|||...||.|.|...||..|..|||. . .|.|. ||. |||..
aekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikga..nkkkkyIatQgPlpstvedFWrmvweekvkiivmlteeeengkekcdrywpee

DQGGLKTPSFVVEFVSQTSDDpydRVILTTELTLIHRLTNERRHVTHVQYLGWPDHGVP-DVDRFLALIDQVESLRAAHprNMYTLVHCSAGIGRTGVVV
 .|  .  .. |..|......   . | ...|.| .  ..| | ||..|| .||||||| . . .|.|. .|.. .     .  ..||||||.||||..|
sggketfgkisvklvevekkk...deiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkksksts..sgpivVhCsaGvgRtgtfv

QTMAMLAILRRKRIPEAAAILRHLREQRARLVQTLQQYEFCFTAVLAK
 .  .|  |...  ..  .|...||.||...||||.|| |. .|.|. 
tidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeailey
PTPc_SM00194 4363-4607 2.9e-72 238.5 In-house 21-261 (263) alignment 
Range on Protein: 4363-4607
Range on HMM: 21-261/263.0
SSSRRNSTKNRYTDILAYDDTRVKLRRGI--TGSDYINANYVTFPneEAPFYFICAQGPTSQTVDDHWQLIWENDVRVIVMVAKLQEDGRSKCAPYWPSS
.   .|..||||..|| ||.||||| .    .|||||||||....  . .  .|..|||...||.|.|...||..|..|||. . .|.|. ||. |||..
aekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikga..nkkkkyIatQgPlpstvedFWrmvweekvkiivmlteeeengkekcdrywpee

DQGGLKTPSFVVEFVSQTSDDpydRVILTTELTLIHRLTNERRHVTHVQYLGWPDHGVP-DVDRFLALIDQVESLRAAHprNMYTLVHCSAGIGRTGVVV
 .|  .  .. |..|......   . | ...|.| .  ..| | ||..|| .||||||| . . .|.|. .|.. .     .  ..||||||.||||..|
sggketfgkisvklvevekkk...deiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkksksts..sgpivVhCsaGvgRtgtfv

QTMAMLAILRRKRIPEAAAILRHLREQRARLVQTLQQYEFCFTAVLAK
 .  .|  |...  ..  .|...||.||...||||.|| |. .|.|. 
tidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeailey
0040438 (Phosphotyrosine protein) phosphatases II 4362-4609 1.7e-71 236.4 In-house 37-277 (317) alignment 
Range on Protein: 4362-4609
Range on HMM: 37-277/317.0
FSSSRRNSTKNRYTDILAYDDTRVKLRR--GITGSDYINANYVTFPNEEAPfyFICAQGPTSQTVDDHWQLIWENDVRVIVMVAKLQEDGRSKCAPYWPS
...   |  ||||.||| ||..||||    |. .||||||.||..||.     ||..|||...||.|.|...||..|.||||. .| |.|| |||.|||.
vaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyvdgpnlkrk..fIatqgPlpntvedFwrmvweqgvtvivmLteleelgrekcaqYwpl

sdQGGLKTPSFVVEFVSQTSddpyDRVILTTELTLIHRLTNERRHVTHVQYLGWPDHGVP-DVDRFLALIDQVESLRAahPRNMYTLVHCSAGIGRTGVV
  .. |.   |.|...| .     .  |  ..|.. .  ..| |.||| .|.|||||||| . | .|.....|.. ..  ...  .|||||||.||||..
..getltygdftvtllseee....lagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfleavreale..dpggpvlVHCsaGvgRtGtf

VQTMAMLAILRRKRIPEAAAILRHLREQRARLVQTLQQYEFCFTAVLAKLK
.    ||  |.... . .  ....|||||.  |||..||.|. .|.|  ||
iaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalleylk
0039614 (Phosphotyrosine protein) phosphatases II 4350-4607 1.9e-71 236.3 In-house 38-288 (297) alignment 
Range on Protein: 4350-4607
Range on HMM: 38-288/297.0
YDSIFRERQGGSFSSSRRNSTKNRYTDILAYDDTRVKLRRGI---TGSDYINANYVTFPNEeAPFYFICAQGPTSQTVDDHWQLIWENDVRVIVMVAKLQ
. .. .     |.. .  | .||||.|||.||..||||        .||||||.||....   .  ||..|||...||.|.|...||..|.||||. || 
feellslkpdysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydl.ltrkfIatqgPlpetvedFwrmvweqgvtvivmLtklv

EDGRsKCAPYWPSSDQgglKTPSFVVEFVSQTSddpyDRVILTTELTLIHrlTNERRHVTHVQYLGWPDHGVP-DVDRFLALIDQVESLRAAHPRNMYTL
|.|| |||.|||.. .   .   |.|.... .     .  . ...|.. .  ..| |.|||.||.|||||||| ... .| ....|.. .|. |..  .|
elgr.kcaqywpeegg...tygdftvtllkveh....ldgytvrtlevtn..ngesrtvthfqytgwpdhgvppslellleflelvrealaelpkggpvl

VHCSAGIGRTGVVVQTMAMLAILRRKRIPEAAAILRHLREQRARLVQTLQQYEFCFTAVLAK
||||||.||||...    ||  |.... . .  ....|||||   |||..||.|.. |.|  
VHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydallel
0045450 (Phosphotyrosine protein) phosphatases II 4336-4605 2.1e-70 233.2 In-house 23-301 (307) alignment 
Range on Protein: 4336-4605
Range on HMM: 23-301/307.0
LDHLTEQRKEAANTYDSIFRERQGGSFSSSRRNSTKNRYTDILAYDDTRVKLRRGI---TGSDYINANYVTF------PNEEAPFYFICAQGPTSQTVDD
||.||  .||    ..   .     |....  | .||||.|||.||.|||||        .||||||.||..      .    .  ||..|||...||.|
ldfltgllkefekllsvtvfllgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydlkrkfIatqgPlpetved

HWQLIWENDVRVIVMVAKLQEDGRSKCAPYWPSSdQGGLKTPSFVVEFVSQTSDDPYDRVILTTELTlihRLTNERRHVTHVQYLGWPDHGVP-DVDRFL
.|...||..|.||||. .| |.|| |||.|||.. .. |    |.|...| . .| | .  |. . .   . |.| |.||| .|.|||||||| ... .|
FwrmlweqgvtvivmltelvelgrekcaqywPde.geeltygnftvtllseehldgytvrtlevtdl...dgtgesrtvthfhytgwpdhgvppsfeell

ALIDQVESLRAAHPRNMYTLVHCSAGIGRTGVVVQTMAMLAILRRKRI---PEAAAILRHLREQRARLVQTLQQYEFCFTAVL
..|..|.. ....|..  .|||||||.||||...    ||  |..  .   . .  ....|||||   ||...||.|.  |.|
dfieevrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyeall
0043336 (Phosphotyrosine protein) phosphatases II 4362-4605 1.1e-68 227.1 In-house 39-274 (278) alignment 
Range on Protein: 4362-4605
Range on HMM: 39-274/278.0
FSSSRRNSTKNRYTDILAYDDTRVKLRR--GITGSDYINANYVTFPNEEAPfyFICAQGPTSQTVDDHWQLIWENDVRVIVMVAKLQEDGRSKCAPYWPs
.. .  | .||||.|||.|| .||||    |  .||||||.||...|      ||..|||...||.|.|...||..|..|||. .| |.|| |||.||| 
iallpenkdknrykdilpydhsrvklsllggdldsdYinAsyvdgynvprk..fiatqgPlpetvedFwrmvwelgvttivmLtelvelgrvkcaqYwp.

sdQGGLKTPSFVVEFVSQTSddpyDRVILTTELTLIHRLTNERRHVTHVQYLGWPDHGVP-DVDRFLALIDQVESLRAahPRNMYTLVHCSAGIGRTGVV
  .| |.   |.|.......    .  . .. |.. .. ..| |.|||..|||||||||| ... .| .. .| . ..  ..|  .|||||||.||||..
..ggsltygdftvtllkeeh....lddytvrtlevtnlgdgesrtvthyhylgwpdhgvpeslsllldflkavreale..dsngpvlVHCsaGvgRTGtf

VQTMAMLAILRRKRIPEAAAILRHLREQRARLVQTLQQYEFCFTAVL
.    .|  |.. . . .  ....|||||.  |||..||.|.. |.|
ialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflyeall
0045098 (Phosphotyrosine protein) phosphatases II 4365-4606 1.3e-68 226.7 In-house 30-270 (278) alignment 
Range on Protein: 4365-4606
Range on HMM: 30-270/278.0
SRRNSTKNRYTDILAYDDTRVKlrrgitgsDYINANYVTFPneeaPFYFICAQGPTSQTVDDHWQLIWENDVRVIVMVAKLQEDGRSKCAPYWPSsdQGG
 . |  ||||.|||.|| .|||        |||||.|....    |. ||..|||. .||.|.|...||....||||...|.|.|| |||.|||.  .| 
ylgnldknRykdilpydhsrVk........dYINAsyidgy....pkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrekcaqywpe..ggs

LKTPSFVVEFVSQTSDDPYDRVILTTELTLIHRLTNERRHVTHVQYLGWPDHGVPDVD---RFLALIDQVESLRA-----------AHPRNMYTLVHCSA
|    |.|...| .  | |  . |. . . ..| ..| |.|||..||.|||||||. .    || |...... ..           .....  .||||||
ltygdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsggpvlVHCsa

GIGRTGVVVQTMAMLAILrrKRIPEAAAILRHLREQRAR-LVQTLQQYEFCFTAVLA
|.||||..|  . ||  |  ..   .  ....||.||    ||.|.||.|.. ..| 
GvgRtGtlvaaylmlell..eggvdlleavkelrsqRpglavqnleqyrflyeflle
subfamily_PTPRD_pd Subfamily PTPRD 4362-4610 2.2e-68 226.3 In-house 42-283 (564) alignment 
Range on Protein: 4362-4610
Range on HMM: 42-283/564.0
FSSSRRNSTKNRYTDILAYDDTRVKL--RRGITGSDYINANYVTFPNeeAPFYFICAQGPTSQTVDDHWQLIWENDVRVIVMVAKLQEDGRSKCAPYWPS
 ..   |  |||| .|.||| .||.|   .|  |||||||...   .  ..  .| .|||...|..| |...||.....|||. ||.| |. ||. |||.
aankpaNkaKNRyanivaYdhsRVvLskvegdegsDYINAsfidgyr..krkayIAtqgPlaetiedFWRmvweqnsstiVmltkleEkgkvkchkYWPe

SdQgGLKTPSFVVEFVSQTSDDPYdrviLTTELTLIHRLTNERRHVTHVQYLGWPDHGVPDV-DRFLALIDQVESLRaaHPRNMYTLVHCSAGIGRTGVV
. .   .  ...|......    |      ....| .  ..| | |.. ..  |||||||.    .|.||..|..|.  .| .  ..||||||.||||. 
k.g.tetygeltVtleeeeelady....eirtfklkkkkssesreVrqFhFtsWPdhgvpesatslLdlirkvraln..epdagPivVhCSaGVGRTGtf

VQTMAMLAILRRKRIPEAAAILRHLREQRARLVQTLQQYEFCFTAVLAKLKA
.   |||  .. ..  .   ....||.||  .||| .|| |...|.|  |..
ividamlerikeektvDiyqyvkalrkqRnamVqteeQYiFiheailealac
Y_phosphatase Protein-tyrosine phosphatase 4368-4605 4.1e-68 224.7 Pfam-A 1-234 (235) alignment 
Range on Protein: 4368-4605
Range on HMM: 1-234/235.0
NSTKNRYTDILAYDDTRVKLRRGITGSDYINANYVTFPNEeaPFYFICAQGPTSQTVDDHWQLIWENDVRVIVMVAKLQEDGRSKCAPYWPSSDQGGLKT
|..||||.|||.||.|||||.   . |||||||||.  .|  .. ||..|||...|..|.|...|...|.||||...|.| || |||.|||..... |..
nkkknRykdilpydktrvklkgsegpsdYInAnyvkgyke..kkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeeslty

PSFVVEFVsqTSDDPYDRVILTTELTLIHRLTN-ERRHVTHVQYLGWPDHGVP-DVDRFLALIDQVESLRaaHPRNMYTLVHCSAGIGRTGVVVQTMAML
 .. || .  ..    .  . ...|.| .. .. |.|.|....| .||||||| ... .| ||..||. .  ....  ..||||||.||||..|  ...|
gdikvelk..ekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkveksk..eaksgpvvVhCsaGvgRtgtfvaldill

AILRRKRIPEAAAILRHLREQRARLVQTLQQYEFCFTAVL
  |.... ..   |...||.||. .||.|.||.|.  |.|
eqleaeeevdvlqivkelRkqRpgmvqsleqYiflykail
Y_phosphatase Protein-tyrosine phosphatase 4368-4605 4.1e-68 224.7 In-house 1-234 (235) alignment 
Range on Protein: 4368-4605
Range on HMM: 1-234/235.0
NSTKNRYTDILAYDDTRVKLRRGITGSDYINANYVTFPNEeaPFYFICAQGPTSQTVDDHWQLIWENDVRVIVMVAKLQEDGRSKCAPYWPSSDQGGLKT
|..||||.|||.||.|||||.   . |||||||||.  .|  .. ||..|||...|..|.|...|...|.||||...|.| || |||.|||..... |..
nkkknRykdilpydktrvklkgsegpsdYInAnyvkgyke..kkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeeslty

PSFVVEFVsqTSDDPYDRVILTTELTLIHRLTN-ERRHVTHVQYLGWPDHGVP-DVDRFLALIDQVESLRaaHPRNMYTLVHCSAGIGRTGVVVQTMAML
 .. || .  ..    .  . ...|.| .. .. |.|.|....| .||||||| ... .| ||..||. .  ....  ..||||||.||||..|  ...|
gdikvelk..ekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkveksk..eaksgpvvVhCsaGvgRtgtfvaldill

AILRRKRIPEAAAILRHLREQRARLVQTLQQYEFCFTAVL
  |.... ..   |...||.||. .||.|.||.|.  |.|
eqleaeeevdvlqivkelRkqRpgmvqsleqYiflykail
subfamily_PTPN3_pd Subfamily PTPN3 4348-4606 6.1e-68 223.8 In-house 19-273 (280) alignment 
Range on Protein: 4348-4606
Range on HMM: 19-273/280.0
NTYDSIFRERQGGSFSSSRR--NSTKNRYTDILAYDDTRVKLRRGITgsDYINANYVTFPNEE--APFYFICAQGPTSQTVDDHWQLIWENDVRVIVMVA
 ... ..| ..| . | .|.  | .|||| |||.||.|||||. . |  |||||||| .  .   .   .| .||| ..|. | ||..||.....|||..
aqfeqlyrkkpglaisaarkpenlsknryrdilpydatrvklkeset..dyinanyvnmeipstglvnryiatqGPlaktatdfWqmvweqksslivmlt

KLQEDGRSKCAPYWPSsDQGGLKTPSFVVEFVSQtsddPYDRVILTTELTLIHRLTNERRHVTHVQYLGWPDHGVPDV-DRFLALIDQVESLRAAHprNM
 | |.|| ||  |||.  .  |.  .| |.  ..      .. ... ||.| .. |.|.|.....||| ||||||||  . || ....|..||...  ..
tlverGrvkChqyWPe.tedeleygefsvkceke....detksyvlrelvlkdketkeerkilqlqylaWpdhgvPddsadflefvervrklrsgk..ee

YTLVHCSAGIGRTGVVVQTMAMLAILRRKRIPEAAAILRHLREQRARLVQTLQQYEFCFTAVLA
 ..||||||||||||..     ||.. ...     .|.|..|.||| |||| .||.|   |.|.
PvvvhCsaGigrtGvlilletalalieaaepvypldivrtmrdqramlvqtasqykfvCeailk
0040439 (Phosphotyrosine protein) phosphatases II 4364-4605 1.8e-65 216.3 In-house 7-243 (249) alignment 
Range on Protein: 4364-4605
Range on HMM: 7-243/249.0
SSRRNSTKNRYTDILAYDDTRVKLR--RGITGSDYINANYVTFPNEEAPfyFICAQGPTSQTVDDHWQLIWENDVRVIVMVAKLQEDGRSKCAPYWPSsd
.   |  ||||.|||.|| .||||   .|  .||||||.|.....      ||..|||...||.|.|...||....||||. .|.| || |||.|||.  
llpenkdknrypdilpydhsrvklsilpglflsdyinAsyidgyyikrr..fiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywpl..

QGGLKTPSFVVEFVSQTSDDPydrvILTTELTLIHRLTNERRHVTHVQYLGWPDHGVP-DVDRFLALIDQVESLRAAHPRNMYTLVHCSAGIGRTGVVVQ
.| |.   |.|...| .. |     . ...|.| .  ..| |.|.|.||..||||||| ... .|..|..|.. ... |..  .|||||||.||||... 
ggsleygdftvtllsvevkdd....ytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfia

TMAMLAILRRKRIPEAAAILRHLREQRARLVQTLQQYEFCFTAVL
   ||  |....   .  ....||.||   ||...||.|.  |.|
aylmleqlekelgvdleeavkllrsqRpgavqnpeqyrflyeall
0042113 (Phosphotyrosine protein) phosphatases II 4364-4605 1.4e-64 213.2 In-house 5-240 (245) alignment 
Range on Protein: 4364-4605
Range on HMM: 5-240/245.0
SSRRNSTKNRYTDILAYDDTRVKLRRGITG--SDYINANYVTFPNEEAPfyFICAQGPTSQTVDDHWQLIWENDVRVIVMVAKLQEDGRSKCAPYWPSsd
.   | .||||.|||.||.|||||    .   ||||||.||....      ||..|||...||.|.|...||.....|||. .. |.|| |||.|||.  
llpenkdknrysdilpydhtrvklspdggdldsdyinasyvdgyritpk..fiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywpl..

QGGLKTPSFVVEFVSQTSddpyDRVILTTELTLIHRLTNERRHVTHVQYLGWPDHGVPD-VDRFLALIDQVESLRAAhPRNMYTLVHCSAGIGRTGVVVQ
.. |..  |.|...| ..    .  . ...|.. .  ..| |.|.|..||.|||||||| .. .| ... |.. .|. ..|  .|||||||.||||... 
gesltygdftvtllseeh....lddytvrtlevtnlgddesrevihyhylpwpdhgvpdllellldflefvrkalae.dsngpvlVHCsaGvgRtGtfia

TMAMLAILRRKRIPEAAAILRHLREQRARLVQTLQQYEFCFTAVL
   ||  |.. .   .  ....||.||   |||..||.|.  |.|
aylmleqlekelgvsleeavkelrsqRpgavqtpsqyrflyeall
subfamily_PTPN14_pd Subfamily PTPN14 4327-4610 5.9e-63 207.6 In-house 7-298 (300) alignment 
Range on Protein: 4327-4610
Range on HMM: 7-298/300.0
KGKDVRQAQLDHLTEQRKeAANTYDSIFRERQGGSFSSSR--RNSTKNRYTDILAYDDTRVKLRRGI-TGSDYINANYVTFPNEEAPFYFICAQGPTSQT
. || |  .|..  |. |     |. | ..|. . .|...   |  |||. |.| |.|.||.|     . ..||||  .  .   .   .| ||||  .|
atkdkrakilekkleegk.vfteyeripkkredallstaklpenaeknrfkdvlPyednrvelsptkenstgyinassikvsvggkersyivaqgPlelt

VDDHWQLIWENDVRVIVMVAKLQEDGRSKCAPYWPSSDQgGLKTPSFVVEFVSQTSDDPYDrVILTTELTLIHRLTNERRHVTHVQYLGWPDHGVP-DVD
| |.||..||..|..|||... .|||. |.  |.|....   ||  |    |..   .  |  . || |.| | ...|.| | |.||  ||||||| ||.
vqdfWqmvWeqgvqlivmlteeeedgkeksfkyfPkles.kkktvefgkfkvttkfsedsd.svittglklkhlpskeertvwhlqytDWpdhgvPeDvk

RFLALIDQVESLRAAHPRNM-------YTLVHCSAGIGRTGVVVQTMAMLAILRRKRIPEAAAILRHLREQRARLVQTLQQYEFCFTAVLAKLKA
 ||  ...|.|.| .  ...         |||||||.|||||.. .  ..| |   .  .   .|..|||||  ||||| ||.| .....  || 
gflsyLeevqsvrrktnseveskeskPPvlvhCsaGvGrtGvlilsdlliatlehneeidikkvlarLreqrmllvqtlaqYkfvYkvlikylkn
0037934 (Phosphotyrosine protein) phosphatases II 4364-4605 1.4e-62 206.8 In-house 6-239 (243) alignment 
Range on Protein: 4364-4605
Range on HMM: 6-239/243.0
SSRRNSTKNRYTDILAYDDTRVKLrrgiTGSDYINANYVTFPNeeapfYFICAQGPTSQTVDD----HWQLIWENDVRVIVMVAKLQEDGRSKCAPYWPs
..  | .||||.|||.||..||||     ||||||||... ..     ..|. |||...||.|    .|...||....||||. .|.| || |||.||| 
llpenlsknrysdilpydhsrvkl....egsdyinanliyvtp.....rliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywp.

sdqGGLKTPSFVVEFVSQTSDDPydrvILTTELTLI-HRLTNERRHVTHVQYLGWPDHGVPD-VDRFLALIDQVESLRAA------HPRNMYTLVHCSAG
   |.     |.|...|... |     .  ..|.|  . |... |.|.|..||.|||||||| .. .|...|.| .   .       ...  .|||||||
...gevtygdftvtllseehldd....ytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaG

IGRTGVVVQTMAMLAILrrkRiPEAAAILRHLREQRAR-LVQTLQQYEFCFTAVL
.||||...    ||  |   .   .  ....|||||    |||..||.|.  |.|
vgRtGtliaaylmllll...g.vdleeavkllreqRpgkavqtpsqyrflyeall
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 4342-4606 2.1e-62 205.8 In-house 19-277 (288) alignment 
Range on Protein: 4342-4606
Range on HMM: 19-277/288.0
QRKEAANTYDSI--FRERQGGSFSSSRRNSTKNRYTDILAYDDTRVKLRR--GITGSDYINANYVTFPNEEApfYFICAQGPTSQTVDDHWQLIWENDVR
.|..  . |.|.  . . . .. ..  .| .|||| .||.|| .||||.     .|.|||||.|.   ...    .|..|||  .||.| |.|..||.. 
nrtgfseeynsLaalektksvtagrlavnakknRyrnilpyDekrvklkkleeeagaDYinasyidgekkkk..kyiatqgPladtvndfWelvyenkts

VIVMVAKLQEDGRSKCAPYWPSSDQGGlKTPSFVVEFVSQTSDDPY-DRVILTTeltlihrLTNERRHVTHVQYLGWPDHGVPDVDR-FLALIDQVESLR
 |||...| |.|..||  |||..|.   .  |. |. |..   . .  | .|          .......|. |||.|||||||.  . .|.|..||.   
tivmltelveggktkCeeYWPdadkpk.nyGsvtvtlveskeledfvlrkllle.......kkkteleitqyqylaWpdhgvPeskapllellrqvkvan

AAHprNMYTLVHCSAGIGRTGVVVQTMAMLAILRRKRIPEAAAILRHLREQRARLVQTLQQYEFCFTAVLA
 |       .||||||.||||. .   |..  ....   . |... .||.||| |||||.||||.. ..| 
qad..tgpiivhCsaGvGrtgtFialdalidaveeedyiDvagtvaklRkqRallvqtlkqYefiyevlls
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 4363-4612 2.7e-62 205.7 In-house 41-284 (318) alignment 
Range on Protein: 4363-4612
Range on HMM: 41-284/318.0
SSSRRNSTKNRYTDILAYDDTRVKLR--RGITGSDYINANYVTFPNEEApfYFICAQGPTSQTVDDHWQLIWENDVRVIVMVAKLQEDGRSKCAPYWPSS
| .  | .||||..|||||.|||||.   | .|||||||||.   ...    .| ||.| ..|..| |...|| . .||||.....| |. |.. ||||.
slepvnkaknryanilaydhtrvkLqmlegeegsDyinanyidGyrrkk..ayiaaqaPlpetieDfWrmvWeqnsavivmltqeeergkakvhryWPsk

dqGGLKTPSFVVEFVSQTSDDPYdrvILtTELTLIHRLTNERRHVTHVQYLGWPDHGVPD-VDRFLALIDQVESLRAaHPRNMYTLVHCSAGIGRTGVVV
  |  .  . |||  .... . |   .|  |... .. ..| |.|   .|  |||.|||. .  .|.|. ||..  . .. .  ..||||||.||||| .
..gsrsygklvvelkeevelsdy...vl.refkvtrteeeesrqvrqyhytsWpdegvpesgaslldlvrqvskaqq.ksgagpivvhCsaGvGrtGvfi

QTMAMLAILRRKRIPEAAAILRHLREQRARLVQTLQQYEFCFTAVLAKLKAAD
   ..|  ..   . .   . ..|||||  .||| .||||.....|  |.. |
avdillerikaealvDvfqtvkqlreqrnlmvqtedqyefiydvllealasgd
subfamily_PTPN13_pd Subfamily PTPN13 4359-4610 1.4e-61 203.2 In-house 28-271 (273) alignment 
Range on Protein: 4359-4610
Range on HMM: 28-271/273.0
GGSFSSSRRNSTKNRYTDILAYDDTRVKLRRGITgsdYINANYVTFPNEEAPFYFICAQGPTSQTVDDHWQLIWENDVRVIVMVAKLQEDGRSKCAPYWP
  . . ...| .|||| ..| ||.|||||    .   ||||...  | ..  . .| .|||  .||.| ||..|| ...||.||.. .|.|. ||  |||
tcevgkkkenkdknryrnvlPydetrvklgdegg...yinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweqkaeviamvtlekekgkvkchrywP

SSDQGGLKTPS-FVVEFVSQTSDDPYDrvilTTELTLIHRLTNERRHVTHVQYLGWPDHGVPDVDrfLALIDQVESLRAAHPRNMYTLVHCSAGIGRTGV
.| .  ||  . . || . ..  | .       .|....  ..| |.|.|...  |||||||     . |.  |  .|  .  .   .|||||||||.|.
esknkklkvsnrlevellkvqkldgfv....vralavkdsesgesrevahlnfvkwPdhgvPssa..aellqfvaevrrlqtdagPivvhcsaGiGrsGt

VVQTMAMLAILRRKRIPEAAAILRHLREQRARLVQTLQQYEFCFTAVLAKLKA
..   ..| .. |..  .   |.|.|||||  .||| .|| |.. |.|  || 
litidvvlglierdkefdvkeivrklreqrqgvvqtkdqyifvykailevlks
subfamily_PTPRB_pd Subfamily PTPRB 4356-4609 2.8e-61 202.1 In-house 39-286 (293) alignment 
Range on Protein: 4356-4609
Range on HMM: 39-286/293.0
ERQGGSFSSSRRNSTKNRYTDILAYDDTRVKL--RRGITGSDYINANYVtfPNEEAPFYFICAQGPTSQTVDDHWQLIWENDVRVIVMVAKLQEDGRSKC
. |  ..... .|..|||||.||.|| .||||   .. .|||||||||.  |. ..|  || .|||  .|||| |...||. ...|||. .| | |. ||
kdqavkaaelavnraknrytnilpydhsrvkLaalkdesgsDYinanyi..pgynsprefiatqGPlpetvddfWrmvwekkssiivmltqlvekgkvkC

APYWPSSDQGgLKTPSFVVEFVSQTSDDPYdrviLTTELTLIHrlTNERRHVTHVQYLGWPDHGVPDV-DRFLALIDQVESLRAAHPRNMYTLVHCSAGI
  |||. ..      .  |..|.... . .     . ||.. .  ..|.|.|.. ... |||||||.  . .|... .|..    . ..  ..||||||.
eeYWPadeep.vlyGdikvtlvaeeeledw....virelkiek..ekeerkvrqyhftsWpdhgvPektktlldfvrtvreaiektaskrPivvhCsaGv

GRTGVVVQTMAMLAILRRKRIPEAAAILRHLREQRARLVQTLQQYEFCFTAVLAKLK
||||. .    .|  .... . . ..|. .|||.|. |||| .|| |  ..||. |.
GRtGtfialdrllqaieeedyvdifgivaelReeRnllvqtekqYifihqcvldllr
subfamily_PTPN12_pd Subfamily PTPN12 4362-4607 8.1e-60 197.1 In-house 34-276 (290) alignment 
Range on Protein: 4362-4607
Range on HMM: 34-276/290.0
FSSSRRNSTKNRYTDILAYDDTRVKLR--RGITGSDYINANYVTFPNEEapFYFICAQGPTSQTVDDHWQLIWENDVRVIVMVAKLQEDGRSKCAPYWPS
 ... .| .|||| ||| || .||.|.  ..  ||||||||..  ....    .| |||| ..|.||.|..||| .|...||. .. | |. ||. |||.
agekeenvkknrykDilPydksrvelskieeeegsdYinanfikgvegk..leyiaaqgPLpktlddfWrmiweknveivvmaCrevelgkkkCerYWpe

SDQGGLKTPSFVVEFVSQtsdDPYDRVILTTELTLIHRltNERRHVTHVQYLGWPDHGVPD-VDRFLALIDQVESLRAAHprNMYTLVHCSAGIGRTGVV
. .  |.. .| |.  ..   .  |  .|   |.. ..  .|.|.|.  .|  |||||||  ... |.||..|..|. ..  ..  .||||||.||||..
egeeelefgefevtleee...kavdddflirtLkveaq..kesrkvyqfhYtaWPDhgvPssaksllelielvrelqese..daPlvvhCsaGvGrtGti

VQTMAMLAILRRKRIPEAAA---ILRHLREQRARLVQTLQQYEFCFTAVLAK
.    .  .|....|||      ....||.||| |||| .|||. . ||.  
iaidyvrellkaekipeeldvfdlvlelrkqraalvqtkeqyelvykavael
subfamily_PTPN9_pd Subfamily PTPN9 4342-4605 1.7e-59 196.3 In-house 14-287 (297) alignment 
Range on Protein: 4342-4605
Range on HMM: 14-287/297.0
QRKEAANTYDSIFRERQGGSFSSS--RRNSTKNRYTDILAYDDTRVKLR--RGITGSDYINANYVTFPNEEAPfyFICAQGPTSQTVDDHWQLIWENDVR
...   . |  | .|   | |  |  | |..||||||.| ||.|||.|    . . |||||||.|   ...    || .|||  .||.|.|...||..|.
gkrGlskeyaeirnepveGtflasklranleknrytdvlcydetrvvlakvdedeasdyinanfvdGykqkka..fiatqGplkktvsdfWrmvWeqevl

VIVMVAKLQEDGRSKCAPYWPSSDQGGLKTPSFVVEFVSQTSDDPYDRviltTELTLIHRLTNERRHVTHVQYLGWPDHGVPDVD-RFLALIDQVESLR-
||||.... | || ||. |||....   .  .. |. |.. . . |      . |.. .  |.| |.||| |.|.|||.|||.    .| ....| . . 
vivmttrvvergrlkcgqyWpleeessaefgdlsvsnveveeeedykv....rvleiknvkteesrkvthfqflsWPdyGvPssaaslldvlekvrekqa

----------AAHPRNMYTLVHCSAGIGRTGVVVQTMAMLAILRRKRIPEAAAILRHLREQRARLVQTLQQYEFCFTAVL
          . ||..   .|||||||||||  .     |. |...   .    ...||.|||  .|| .|||||. |||
lavkelgdewkghpsgPPivvhcsaGiGrtGtfitldiclsrleevgtvdvvetvkllrtqrafsiqtpeqyefcylavl
subfamily_PTPN6_pd Subfamily PTPN6 4365-4609 1.9e-58 192.9 In-house 51-298 (306) alignment 
Range on Protein: 4365-4609
Range on HMM: 51-298/306.0
SRRNSTKNRYTDILAYDDTRVKL-RRGITGSDYINANYVTFPNEEAPFYFICAQGPTSQTVDDHWQLIWENDVRVIVMVAKLQEDGRSKCAPYWPSSDQG
  .| .||||  || .|.|||.| . ...|||||||||..   ..   ..| .||  ..|| | |...|... |||||. |  | |..|||.|||.. . 
kpenkeknryknilPfDhtrvilkepsvpgsdyinanyikkevkgsdksyiatqgclettvsdFWrmvwqensrvivmttkevErgkekCarYWPdeeek

GLkTPSFVVEFVSQTSDDPYDrvilTTELTLIH-RLTNERRHVTHVQYLGWPDHGVP-DVDRFLALIDQVESLRAAHP--RNMYTLVHCSAGIGRTGVVV
   . .  |. ||..| . |.      ||.. . .  .| |.| . ..  ||||||| | . .|.....|.. .      ..  ..||||||||||| ..
ee.yGkisvtnvseksladYi....lRelsvskkkkkkeerevfqyhfksWPdhgvpkdpgavLdfledvnrkqeeleeaeagpivvhCsaGiGRtGtfi

QTMAMLAILRRKRIPE---AAAILRHLREQRARLVQTLQQYEFCFTAVLAKLK
 . ..| ....| .        . . .||||  |||| ||| | ..|. . ..
viDillkliekkgldadidiqklvksvreqrsglvqteqqykfvykaikkyie
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 4338-4609 3e-58 192.2 In-house 9-277 (281) alignment 
Range on Protein: 4338-4609
Range on HMM: 9-277/281.0
HLTEQRKEAANTYDSIFR-E-RQGGSFSSSRRNSTKNRYTDILAYDDTRVKL--RRGITGSDYINANYVtfPNEEAPFYFICAQGPTSQTVDDHWQLIWE
. ... .  ...|...   . ..  . | .  | .||||..| ||| ||||.      . .||||||.|  |  . .  .| .|||  ..... ||..||
lsqndnaGfieeyeklaaigvdntataskadenvlknrYsnivaYDatrvkvtpneenkntDYinanfv..pgykgekeyiatqgPvPaslvafWqmvwe

NDVRVIVMVAKLQEDGRSKCAPYWPsSDQGGLKTPSFVVEFVSQTSDDPYdrviLTTELTLiHRLTNERRHVTHVQYLGWPDHGVPDVD-RFLALIDQVE
..|..||||..  | |. ||  |||  |.  ||   ..|.......   |    .. ...| .| ..| |.|....|. |||||||.    .|   ..|.
qkvsaivmvtreieagklkChrYWP.ddnselkygdvtvkstaeeekaty....ierkfkl.eresgetreveqlaytaWPdhGvPattkellefrkevl

SLRAAHpRNMYTLVHCSAGIGRTGVVVQTMAMLAIL-RRKRIPEAAAILRHLREQRARLVQTLQQYEFCFTAVLAKLK
.|.  . ...  ..|||||.||||. .    ..  . ....  .  |....||..|  .|||. |||| . |||  |.
kltekk.tkaplvihCsaGvGrtGtyialDrlvkaveaeleeldvkavvaelrkernlmvqtvvqyefvykavldald
subfamily_PTPN23_pd Subfamily PTPN23 4331-4610 9.7e-58 190.2 In-house 6-282 (288) alignment 
Range on Protein: 4331-4610
Range on HMM: 6-282/288.0
VRQAQLDHLTEQRKEAANTYDSIFRERQGGSFSSSRRNSTKNRYTDILAYDDTRVKLRrgITGSDYINANYVTFPNEEAPfYFICAQGPTSQTVDDHWQL
.....||  |.  |. ..  ..  .| .. | . ....|.|||..||| || .|||||   .  ||||| .|      .|  ||..|.|  .|. | |..
lqrkmldgktaldkkfkeleqkqdkearkrsiaiaklyseknrsrdilPyDhnRvklr..gskDDYinAsfvkdlspgcP.dfiatqaPlqstlnDFWlm

IWENDVRVIVMVAKLQEDGRSKCAPYWPSSDQGGLKTPSFVVEFVSQTSDDPYDRviltTELTLIHRLTNERRHVTHVQYLGWPDHGVPD-VDRFLALID
..|. ..||||. . .| |. |.. |||..     | . . |   |... ... .     .|.| .. ... ..|.|.|.  ||..|||.  . .|...|
vyeqkssviVmllskeelgkpkvdrYwPedkgetvkfgdlsvtlksvretethve....rvlkletldadavksvshlqltsWpelGvPasPetllqfld

QVESLRAAHPRNMYT--LVHCSAGIGRTGVVVQT-MAMLAILRRKRIPEAAAILRHLREQRARLVQTLQQYEFCFTAVLAKLKA
.|||   |. |.. |  .||||||.|||||.     |. .. ... ...   ....|||||   ||. .|..|.. ||| . . 
evesayeavqrksktPlvvhCsaGvgRtgvfalvyaavrelekgnglldiiqvvsrlreqRrfmvqekeqlkfsyeavleaarr
subfamily_Ptp69D_pd Subfamily Ptp69D 4350-4607 6.7e-56 184.7 In-house 28-285 (307) alignment 
Range on Protein: 4350-4607
Range on HMM: 28-285/307.0
YDSIF--RERQGGSFSSSRRNSTKNRYTDILAYDDTRVKLRR--GITGSDYINANYVTFPNEEapFYFICAQGPTSQTVDDHWQLIWENDVRVIVMVAKL
|...      .  ..|    |  |||| || |.|.|||||..  |   ||||||...   .|.  . ||.||.|  .|..| |..|.| .| .|||...|
yekLeareidkstkvsekkenalknRyedikafDktRvkLkkingkedsdYinasfikgykek..kkfiaaqdPveatigDfWRmiaeqevtlivmlsnl

QEDGRSKCAPYWPSSDQGGLKtpSFVVEFVSQTSDDPYD-RVILTTELTLIHRLTNERRHVTHVQYLGWPDHGVPDVDR-FLALIDQVESLRAAHprNMY
.|  | ||| |||  |.      . .|..||. . . |  | .  ..        ...|.|.  .|.||.|  ||.| |  | ||.||..|   .  .  
teknrkkcakYWpiedevqyg..dilvklvseekhsdyiiReldvskkkeesgevedsrkvvqyhytgWkDskvPevargllklieqvrelykln..rsP

TLVHCSAGIGRTGVVVQTMAMLAILRRKRIPEAAAILRHLREQRARLVQTLQQYEFCFTAVLAK
 .|||||| ||.|..|    .|  |.     .  .. ..||.||  ||| |.||.|.. |.|  
ivvhCsaGvgrsgifvaldsllqqlkaedkvdifetvkdLrsqRnllvqsleqYvflyralldy
subfamily_PTPRK_pd Subfamily PTPRK 4348-4606 1.7e-55 183.0 In-house 26-275 (314) alignment 
Range on Protein: 4348-4606
Range on HMM: 26-275/314.0
NTYDSIFRErqgGSFSSSRRNSTKNRYTDILAYDDTRVKLRR--GITGSDYINANYVtfPNEEAPFYFICAQGPTSQTVDDHWQLIWENDVRVIVMVAKL
. |.|.|        .    | .|||..|||||| .||.|    | . ||||||...     . |  || .|||  .|| | |.|.....   |||...|
eeyeslfeg...wdaakkdenreknrsgdilaydrsrvflitidgdpssdyinaali..dsykrpaafivtqgPlqetvkdfWrlvydencasivmltel

QEDGRSKCAPYWPSSDQGglkTPSFVVEFVSQTSDDpyDRVILTTELTLIHRLTNERRHVTHVQYLGWPDHGVPDVDR-FLALIDQVESLRAAhpRNMYT
.| || ||  |||   .       . ||.|. . .   . |. .  .. ..|  .|.| | ..|.||||||.||   . .|.|. .|.. ..   ..  .
vevgrvkClkyWPedtev...ygdikvelvetella..elvvrifrveklargqeeirevrqfqflgWpdhdvPvsatgllklvrrvkksqee..eaGri

LVHCSAGIGRTGVVVQTMAMLAILRRKRIPEAAAILRHLREQRARLVQTLQQYEFCFTAVLA
.|||||| ||||. .    .| ...|... .   . . ||...  .|.| .|| |.. ..| 
vvhCsaGaGrtGtfiaidivldmieregvvdvfnavktlrsrkvnmveteeqykfiydvile
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 4361-4611 9.6e-55 180.9 In-house 49-293 (298) alignment 
Range on Protein: 4361-4611
Range on HMM: 49-293/298.0
SFSSSRRNSTKNRYTDILAYDDTRVKLRR--GITGSDYINANYVTFPNEEApfYFICAQGPTSQTVDDHWQLIWENDVRVIVMVAKLQEDGRSKCAPYWP
. .....|  ||||.||.|.| .|| |..  .   |||||| ..   ...    || .|.|  .|| | |....|.|. .|||. .|.| .. |.  |||
evarkpenkkkNRyadiialdssRvvLekedadeesdYiNAsflhaykgrn..afiatqaPltetvedFWrmvteedigtiVmltnleeldktkyhkywP

SSDQggLKTPSFVVEFVSQTSddpYDRVIlTTELTLIHRLTNERRHVTHVQYLGWPDHGVPDVDR-FLALIDQVESlRAAHPRNMYTLVHCSAGIGRTGV
.. .   .  .. |.  |. .   .  .| ...|.. .. ....|.| ....  |||.||| . .  |.|...|.     .  |   .|.||||.||.| 
degk..etygeitvsllskee...fadli.vrklkvskkkeekerevrqlhftsWpdkgvpenatsvldllrkvra.sqqqagnkpvivqCsaGvgRsGt

VVQTMAMLAILRRKRIPEAAAILRHLREQRARLVQTLQQYEFCFTAVLAKLKAA
 .   ..|  .....  .   ... ||..|. .||| .|| |...|||  |.. 
fiaidsvlervkkeqvvDvfqvvkvlRkkrpgavqteeqYvfiyeavlealdsf
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 4363-4612 1.5e-54 180.2 In-house 43-287 (319) alignment 
Range on Protein: 4363-4612
Range on HMM: 43-287/319.0
SSSRRNSTKNRYTDILAYDDTRVKLR--RGITGSDYINANYVTFPNEEAPfyFICAQGPTSQTVDDHWQLIWENDVRVIVMVAKLQEDGRSKCAPYWPSS
.|  .|..||||..||||| |||.|    |. |||||||...   .|.    || .|.| ..|..| |...||... ..||..||.| .. |.  |||. 
askeenkkknryqnilaydrtrvvlseldgvegsdyinasfidgyqerek..fiatqaPlentiedfWrmvWeeessivvmltklveklkvklkkywpee

D--QGGlktpSFVVEFVSQTSDDPYdrvIlTTELTLiHRLTNER--RHVTHVQYLGWPDHGVPDVDrfLALIDQVESLRAAHPR--NMYTLVHCSAGIGR
.  ..|     ..|.  ..   . |   |   .|.| .....|   |.|.| ||. ||||.||.    ..|.| .. .| .. .  .    ||||||.||
nfeeyG....rlivtleeeeeledy...i.irklkl.nkkssevetRevkhfqyteWpdhdvPeka..tslldllkrirksrektqsgPivvhCsaGvGR

TGVVVQTMAMLAILRRKRIPEAAAILRHLREQRARLVQTLQQYEFCFTAVLAKLKAAD
||  .   |||  ...  . .   . ..|| ||  .||. .||.|.. |.|. ..| |
tGtfivldamlervkeegvlDvfstvsrlRtqRnimvqrpeqYkfiyealleaveagd
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 4364-4606 1.5e-54 179.8 In-house 16-262 (270) alignment 
Range on Protein: 4364-4606
Range on HMM: 16-262/270.0
SSRRNSTKNRYTDILAYDDTRVKLRRG--ITGSDYINANYVTFPNEeAPFYFICAQGPTSQTVDDHWQLIWENDVRVIVMVAKLQEDGRSKCAPYWPSSD
.  |... |||.|||    |||.| .      . |||||||   .. .. ..|.|.||.  |. ..|..|||. |. |||...|.|.||.||. |||.. 
eaargkklnRyadiLPsPatRvrleeleedsataYinAnyvrGfdg.ekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkgrkkCerYWpaep

QGGLKTPSFVVEFVSQtSdDPYDRVILTTELTLIhRLTNERRHVtHVQYLGWPDHGVPDVDR-------FLALIDQVESLRAAHPRNMYTLVHCSAGIGR
.  .|.    .. ... | .  ..  ..|.|.|  .  .||| | | .|  |||||||  .         |... .|   .  . ..  .|||||||.||
kekvkledgkikvlal.s.eekeegyiltrlrle.ekgeerrlv.HfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkaePllvHcsaGvgR

TGVVVQTMAMLAILRRKRIPEAAAILRHLREQRARLVQTLQQYEFCFTAVLA
||... .  .. .| ...  . .||...||..|  |||. .|||| . ||. 
tGtlialDiavrlLeetkkvdvlaiieelRkdRmalvqhpeqyeflykavve
subfamily_PTPRG_pd Subfamily PTPRG 4361-4610 1.6e-53 176.8 In-house 40-289 (563) alignment 
Range on Protein: 4361-4610
Range on HMM: 40-289/563.0
SFSSSRRNSTKNRYTDILAYDDTRVKLRR--GITGS-DYINANYVTFPNEEAPfyFICAQGPTSQTVDDHWQLIWENDVRVIVMVAKLQEDGRSKCAPYW
..|. . |  ||||..|.||| .||||.   |. .. |||||||.   . .    || .|||  .|.|| |..|||. | .|||...|.|.|| ||  ||
ehsqkpenkrKnRylnivaydrsRvklsplpgkkkklDYinAnyidGyqkska..fiatqgplkdtfddFWrmiWeqnvaiivmitnlvergrrkcdvYW

PSsdQGGLKTPSFVVEFVSQTSDDPYD-RVILTTELTLIHRLT-NERRHVTHVQYLGWPDHGVPDVDRFlALIDQVESLRAAHPRNMYTLVHCSAGIGRT
|.  .. ..  .. |  ...     |  | .   .| | .    .. ..|.. .|  |||||||.   .  ||  . | .| .     ..||||||.|||
Pk..desetygalqvtlieeevlalytvrtlviknlklkkkkqcdteklvrqyhytkWPdhgvPehslp.vLifvkkssaankaeaGPivvHcsaGvgrt

GVVVQTMAMLAILRRKRIPEAAAILRHLREQRARLVQTLQQYEFCFTAVLAKLKA
|. .   ..|  .... . .   .|.|.| ||  ||||  || | . |.|  ...
GtyivldtllkqiqqenavnvfgflkhiraqRnflvqteEqYiflhdalleaias
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 4361-4606 3.1e-53 176.1 In-house 54-289 (319) alignment 
Range on Protein: 4361-4606
Range on HMM: 54-289/319.0
SFSSSRRNSTKNRYTDILAYDDTRVKLRR--GITGSDYINANYVTFPNeeAPFYFICAQGPTSQTVDDHWQLIWENDVRVIVMVAklqedgRSKCAPYWP
.|.   .|  |||...|||.| ..|||.|  |. .|||||| .||      .  .| ||||   |..| |..||| ..  ||...      . ||. |||
tfanldqnkdknriinilafdknvvklerliGeefsdyinasfvtGyq..rkdkyiaaqGPldntladfWrmiweyncstivllt......kdkcsqywp

SSDQGGLKTPSFVVEFVSQTSDdpydRVILTTELTLIHRLTnERRHVTHVQYLGWPDHGVPDVD-RFLALIDQVESLRAAHPRNMYTLVHCSAGIGRTGV
   .   .     |. | .|..     |.   ||.   . . . |..|   .|||||.||||    .. |...|. |.     .   .||||||.|||||
lkivikeerfkvkvdsveetae....yvvrdielsedgkek.dirkitqfhflGwpdvGvpdypsdlmrlvkkvrhltskenhranivvhcsaGvGrtGv

VVQTMAMLAILRRKRIPEAAAILRHLREQRARLVQTLQQYEFCFTAVLA
 .   ..|  .....  .   ..| ||.|| .||| | || |...|.| 
yivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalle
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 4362-4606 1.4e-52 173.9 In-house 19-253 (284) alignment 
Range on Protein: 4362-4606
Range on HMM: 19-253/284.0
FSSSRRNSTKNRYTDILAYDDTRVKLRR--GITGSDYINANYVTFPNeeAPFYFICAQGPTSQTVDDHWQLIWENDVRVIVMVAklqedgRSKCAPYWPS
|.   .|  |||...|||.| ..|||.|  |. .|||||| ..|      .  .| .|||   |..| |..||| ..  ||...      . ||. ||| 
fanldqnkdknrighilafdknvvklerliGeefsdyinasfitGyq..rkdkyiatqGPldntladfWrmiweyncstivllt......kdkcsqywpl

SDQGGLKTPSFVVEFVSQTSDdpydRVILTTELTLIHRLTnERRHVTHVQYLGWPDHGVPDVD-RFLALIDQVESLRAAHPRNMYTLVHCSAGIGRTGVV
  .   .     |. |.....     |.   ||.   . . . |...   .|||||.||||    ...|...|. |.  .  .   .||||||.||||| 
kivikeerfkvkvdsveesee....yvvrdielsedgkek.dirkirqfhflgwpdvgvpdypsdlmrlvkkvrhltskenhranivvhcsagvgrtgvy

VQTMAMLAILRRKRIPEAAAILRHLREQRARLVQTLQQYEFCFTAVLA
.   ..|  .....  .   ..| ||.|| .||| | || |...|.| 
ivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalle
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 4342-4611 1.8e-52 173.4 In-house 20-286 (305) alignment 
Range on Protein: 4342-4611
Range on HMM: 20-286/305.0
QRKEAANTYDSIFRERQGGSFSSSRRNSTKNRYTDILAYDDTRVKLRRGITG--SDYINANYVTFPNEEApfYFICAQGPTSQTVDDHWQLIWENDVRVI
. |.  . |.|. .| .     ..  | .|||...|  .|| |..|.   .   ||||||.||   ...    .| ||||  .||.| |.||.|  |..|
sdkgleaqykslyeeeesidvgkkeankaknrlkeitlldddriiltekeslddsdyinasyvdgykrkk..kyivaqgPlkntvadfWrliveekvsti

VMVAKLQEDGRSKCAPYWPSSDQGGLKTPSFVVEFVSQTSDDPYdrviLTTELTLI-HRLTNERRHVTHVQYLGWPDHGVPDVD-RFLALIDQVESlRAA
||..||.|.|..||  ||| | .   .  .|.||  |...   |    .. .|..  ..  .| | |.. |   |||||||.    .| ||..|.  .  
vmltklveggkdkCrqYWpesktekkefgefsvelksektasdy....ieRklkisiededkesrtvlqyqltdWPdhGvpqfatsllslikrvqk.dqk

HPRNMYTLVHCSAGIGRTGVVVQTMAMLAILRRKRIPEAAAILRHLREQRARLVQTLQQYEFCFTAVLAKLKAA
. ...  |||||||.||||| .    .|  |..  . . . .|..||..|  .||||.|| |.. |.   ... 
kdkgvpllVhCsagvgRtGvfiavdialerlkkEevvdvfevlkqlRskrmkmvqtldqYvflhdaldelitcg
subfamily_PTPRA_pd Subfamily PTPRA 4362-4606 3e-52 172.5 In-house 52-293 (330) alignment 
Range on Protein: 4362-4606
Range on HMM: 52-293/330.0
FSSSRRNSTKNRYTDILAYDDTRVKL--RRGITGSDYINANYVTFPNEEApfYFICAQGPTSQTVDDHWQLIWENDVRVIVMVAKLQEDGRSKCAPYWPs
 .|   |  |||. .|| || .|| |  ..|.  |||||| ..   .|    .|| |||| ..||.| |..||| .   |||...|.|  ..||| ||| 
laskeenkeknrvvnilPydfsrvilsvkeGveesdyinasfidGykekd..kfiaaqGPkeetvedfwrmiweqksativmltelkerkeekcaqywP.

sDQGGLKTPSFVVEFVSQTSDDPYD-RVILTTELTLIHRlTNERRHVTHVQYLGWPDHGVPDVD-RFLALIDQVESLRAAHPRnmYTLVHCSAGIGRTGV
 |.| .      ||   .|    |  | .| ..|.   |  .. | |. . . .||| |||      | |. .|..|.  .       ||||||.|||| 
.deGlvtyGnirvevedetvlvdytvrkflvqqlpdatr.ekksrlvrqfhftswPdvGvPfepiGmlkllkkvkklnqqsag..pivvhcsaGvGrtGt

VVQTMAMLAILRRKRIPEAAAILRHLREQRARLVQTLQQYEFCFTAVLA
 .   |.|. .. .|. .   ....|| ||...|||..||||.. ..| 
fivldavlervkaerkvdvfefvkrlrlqrpqmvqtdeqyefiykvlle
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 4367-4609 3.1e-51 169.1 In-house 27-269 (274) alignment 
Range on Protein: 4367-4609
Range on HMM: 27-269/274.0
RNSTKNRYTDILAYDDTRVKLRRGITGS---DYINANYVTFPNEEAPFyFICAQGPTSQTVDDHWQLIWENDVRVIVMVAKLQEDGRSKCAPYWPSSDQG
...|||||..||  . .|| |..  . .   .||||||.  ..||    .. .||| ..||.| |..|....|.||||..||.|  ..||| |.| . . 
gsqtknryktilPnensrvllesessededssyinanyikGydeeska.yvatqGPlpntvadfWrmiyqeevqvivmltklkeaneqkCavyfPdaedy

GLKT--PSFVVEFVSQTSDDPYDrviLtTELTLIHRLTneRRHVTHVQYLGWPDHGVPD-VDRFLALIDQVESLRAAHPRN-MYTLVHCSAGIGRTGVVV
 ..     . ..... .. . |    . ..|.| .     .|.|.|  |  |||| .|| .. .| |...||. | ..  .   ..|||||||||||. .
eiserygdveikvekiverndys...v.rklvlkyler..ersvkhywytdWPdhksPddantlldlvleveesreeenaklapvvvhCsaGiGrtGcfi

QTMAMLAILRRKRIPEAAAILRHLREQRARLVQTLQQYEFCFTAVLAKLK
 .   .  ||.. . .   |  .|| .|  .||| .|||. . |.   ||
aisiavrqlreeivvdvlkivcnlrldrGGmvqtseqyelihralclylk
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 4365-4609 5.3e-51 168.3 In-house 41-278 (315) alignment 
Range on Protein: 4365-4609
Range on HMM: 41-278/315.0
SRRNSTKNRYTDILAYDDTRVKL--RRGITGSDYINANYVTFPNEEApfYFICAQGPTSQTVDDHWQLIWENDVRVIVMVAKLQEDGRSKCAPYWPSSDQ
 . | .|||| .|| .| .||||     .  |||||| |.   ...    .|..|||   .||| |.......|  ||||.|.||. . ||. |||  . 
etinfkknryknilPldsarvkleviddsPdsdyinasyiksvdddk..ayiasqgPlkasvddfwrmvlqekvttivmvtkkqegdkikcrqywPdrka

GGLKTPSFVVEFVSQTSDDpyDrvilTTELTLIHRLTNERRHVTHVQYLGWPDHGVPDVDRflALIDQVESLRAAHPRNMYT-LVHCSAGIGRTGVVVQT
   .  |. || .|  .|   |    ..   |. | ..| | ||  |. .|||.||.      .|.  .  ..| . .. .. |||||||.||||||.  
dsvefGsikvellsleadt..d....gvarklvtrkseesrtvtqfqftewPdkGvdkqts..sllklikevkadngkkefsllvhcsaGvGrtGvvisi

MAMLAILRRKRIPEAAAILRHLREQRARLVQTLQQYEFCFTAVLAKLK
. ..| ..|.|  .   ... ||..|  |||| ..| | . ||| .|.
devvaqikrtrsvdvfnfvknlrakrpylvqteeeyafiydavledll
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 4367-4609 7.7e-51 167.7 In-house 42-277 (515) alignment 
Range on Protein: 4367-4609
Range on HMM: 42-277/515.0
RNSTKNRYTDILAYDDTRVKL--RRGITGSDYINANYVT-FPNEEApfyFICAQGPTSQTVDDHWQLIWENDVRVIVMVAKLQEDGRSKCAPYWPSSDQG
 | .|||| .|| || .||||        |||.|| |.  | |. |   .|..|||   .||| |.|.....|  |.||.||.|. ..||. |||     
infkknryknilPydsvrvklevindnPhsdyfnasyipsfdndka...yiasqgPnkasvddfWrlvlqenvttiamvtklkegdkikcgkyWPdkpgd

GLKTPSFVVEFVSQTSDDpyDRviLTTELTLIHrlTNERRHVTHVQYLGWPDHGVPDVdrFLALIDQVESLRAAHPRNMYT-LVHCSAGIGRTGVVVQTM
 .|  |. || ||  ..   .   .  .||...   .. | ||  .. .|||.|||      .|.  .  ..| | .  .. ..|||||.||||||.  .
svkfGsikvelvsleact..gg..ikrkltvlk..gddsrtvtqfhfteWPdkGvpkh..tssllklikevkadhgqythpliihcsaGvGrtGvvisid

AMLAILRRKRIPEAAAILRHLREQRARLVQTLQQYEFCFTAVLAKLK
 ..|  .  |. .   ... .|..|  |||| .|| | . ||| .|.
svvahakttrmvdvfnfvtnirqkrpylvqtqeqyafiygavledll
subfamily_PTPN1_pd Subfamily PTPN1 4362-4608 8.7e-50 164.1 In-house 26-271 (290) alignment 
Range on Protein: 4362-4608
Range on HMM: 26-271/290.0
FSSSRRNSTKNRYTDILAYDDTRVKLRRGITgsDYINANYVTFPneEAPFYFICAQGPTSQTVDDHWQLIWENDVRVIVMVAKLQEDGRSKCAPYWPSSD
 .   .| ..||| |.  || .|.||.|. .  |||||. | ..  ||   .| .||| ..|||  ||..||.. . .||. |. | .. ||| |||. .
eaklpenrnlnryrdvspydhsrikleradn..dyinaslvele..eakrsyiltqGPlpntvdhfWqmvWeqkskavvmlnkvvekeqikcaqywPqge

Q-GGLKTP--SFVVEFVSQTSDDPYDRVIltteLTLIHRLTNERRHVTHVQYLGWPDHGVPDV-DRFLALIDQVESLRAAHPRNMYTLVHCSAGIGRTGV
.   |.    .. |...|. . . | . .    | |  . |.| |...|  |. ||| |||.    || .. .| .  .  .    ...||||||||.| 
eekellledtklkvkliseerksyytvrl....lelenlktqetreilhfhyttwpdfgvpespaaflkflfkvresGslssdvGpavihcsaGiGrsGt

VVQTMAMLAILRRKRIPEA---AAILRHLREQRARLVQTLQQYEFCFTAVLAKL
..   ..|. . .|   ..      | .||..|  |.|| .| .| ..|.|   
fclvdtclvliekkddlssvdikkvllelrkyrlGliqtadqlrfsylaileGa
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 4365-4610 1.8e-49 163.2 In-house 6-244 (250) alignment 
Range on Protein: 4365-4610
Range on HMM: 6-244/250.0
SRRNSTKNRYTDILAYDDTRVKLRRGI--TGSDYINANYVTFPNEEapFYFICAQGPTSQTVDDHWQLIWENDVRVIVMVAKLQEDGRSkCAPYWPSSDQ
  .|  ||||.||.|.| .|| | .      |||||| ..   .|.    || .||| ..|. | |....|... .|||...|.| ..  .  |||    
kpqnkeknryadiialdssrvvLekekgdkesdyinasflhgyder..kafiatqgPlqatiedfWrmvleeksgtivmLtnLkesekt.yhqywPveka

ggLKTPSFVvefVSQTSDDPYDRVIlTTELTLIHRLTNERRHVTHVQYLGWPDHGVPDVDR-FLALIDQVeslRAAHPR--NMYTLVHCSAGIGRTGVVV
   |  .     ||  |.. .  .. ...| | ..  ...|.| ..... ||| |||.| .  |.|...|   .| ...  |   .|.||||.||.|  .
..ekyGdvt...vsllskeefadyt.krklklskakkaderivrqlhfvvWPdkgvPevatavLellkkv...qasqqqagnaPvivqCsaGvgrsGafi

QTMAMLAILRRKRIPEAAAILRHLREQRARLVQTLQQYEFCFTAVLAKLKA
   |.|  |..... .   ... ||..| . |..|.|| |.....|  |..
aidavlerlkkekvvdvfkvikvlrkdrphavesleqyvfvyeiilkalds
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 4352-4611 2.6e-49 162.5 In-house 28-280 (287) alignment 
Range on Protein: 4352-4611
Range on HMM: 28-280/287.0
SIFRER----QggsfsssrrnSTKNRYTDILAYDDTRVKL-RRGITGSDYINANYVTFPNEEAPfyFICAQGPTSQTVDDHWQLIWENDVRVIVMVAKLQ
 .|..     .            ||||.|.| .||||| |   |  ||||||||||.  ...    ||.|||| . || | |....|. . .......  
atfkaaeelaa..........vkknryadvlPiddtrvllsaegelGsdyinanyvasytddea..fiaaqgPiaatvrdfwravletrsasvitmtrev

EDGRSKCAPYWPSSdQGGLKTPSFVVEFVSQTSDDPYdrvILTTELTLIHRLTNERRHVTHVQYLGWPDHGVPDV----DRFLALI-DQVESLRAAHPrN
|..| ||  |||   .  ..   . |  ....  .|      .  | ||.  |.| | |  ...| |||....       ||   . ...|  | |    
eearlkcykywPer.evPmrvGGysvvlldydikePe...ygvralrlidletrearvvkqldllswPdkvlaPtavglirfvldvkqhielardase.v

MYTLVHCSAGIGRTGVVVQTMAMLAILRRKRIPEAAAILRHLREQRARLVQTLQQYEFCFTAVLAKLKAA
   .||...||||.|....|....  |      ..||.. .|||.|| |||.  |. . . |. .  |. 
GPlvvhddvGiGrsGillatlvlvsrledlGrvdvaavvirlreyraalvqavvqlrllyealvtyyktn
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 4365-4614 2.9e-45 149.7 In-house 48-290 (297) alignment 
Range on Protein: 4365-4614
Range on HMM: 48-290/297.0
SRRNSTKNRYTDILAYDDTRVKLRRGITG--SDYINANYVTFPNEeapfYFICAQGPTSQTVDDHWQLIWENDVRVIVMVAKLQEDGRsKCAPYWPSSdq
 . |  |.||..|| ||  ||||.   .   |||.|| .|   ..     .|. | |  .||.| |.......| .|||.....|  . ||| ||. .  
kkvnfeksRYkniLPydssRvkLaivnddpdsDyvnasfvkgnkh....rlittqmPmkatvadfWamvldeqvstivmlnddnerdk.kcaryWsdk..

GGLKTPSFVVEFVSQTSDdpydRVILTTELTLIHRLTNERRHVTHVQYLGWPDHGVPDVDRFLALIDQVESLRAAHPRNMY--TLVHCSAGIGRTGVVVQ
|  .  . .|.  | ..     .  .  ||.. .  .  || |   |.. |||. |.  |.  .|.. .. .|  .  |     ||||.||.|||||.. 
gvttfGdvsvvllsvser....eGfikrelevtkgkakarrvvkqyqfveWPdkaverkdsassllklisevrkdfsqnaegPllvhclaGvGrtgvllt

TMAMLAILRRKRIPEAAAILRHLREQRARLVQTLQQYEFCFTAVLAKLKAADWR
   ..|  .|.   .   ....||..|  |||| .||.| . |||  | . | |
idsvvaeakrekevdifglvkklrqerpylvqtkeqykfvyvavleallsedtr
subfamily_PTPRN_pd Subfamily PTPRN 4337-4608 3.4e-44 145.7 In-house 23-292 (297) alignment 
Range on Protein: 4337-4608
Range on HMM: 23-292/297.0
DHLTEQRKeAANTYDSIFR---ERQGGSFSSSRRNSTKNRYTDILAYDDTRVKLRRG--ITGSDYINANYVTFPNEEAPFYfICAQGPTSQTVDDHWQLI
|||... .  .. .... .   | .  . ... .| .|||....|.||..||||..    . ||||||  ..  .  || | | .||| ..|| | ||..
dhlknkdr.lekewealcayeaepstkevakaeknvkknrskavlpydhsrvklkeeasaeksdyinasaildhdprapay.iatqgplastvadfwqmv

WENDVRVIVMVAKLQEDGRSKCAPYWPssDQGGLKTPSFVVEFVSQT--SDDpydrvILTTELTLIHRLTNERRHVTHVQYLGWPDHGVPDVDRFL-ALI
||. | |||....|.|.| ..|. |||  |.|      . |..||.   .||      |   . |    |.| | ||   .| ||..|||   . |  . 
weqGvvvivnltrleeegvkqckrywp..deGsevyhiyevhlvsehiwcdd.....ylvrsfylknlqtsetrtvtqfhflswpeegvPasaksllefr

DQVEslRAAHPRNMYTLVHCSAGIGRTGVVVQTMAMLA-ILRRKRIPEAAAILRHLREQRARLVQTLQQYEFCFTAVLAKL
 .|.  ..   |    .||||.| ||||| .    .|. .|.  .  . || | |||.||. ||.| .|.||..|||  ..
rkvn..ksyrGrscpivvhcsdGaGrtGvyilidlvlnrllkGvkeidiaatlehlrdqrpglvktkdqfefaltavaeev
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 4349-4609 5.8e-44 145.1 In-house 28-284 (290) alignment 
Range on Protein: 4349-4609
Range on HMM: 28-284/290.0
TYDSiFRERQGGSFSSSRRNSTKNRYTDILAYDDTRVKLRRGITGSD----YINANYVT-FPNEEApfyFICAQGPTSQTVDDHWQLIWENDVRVIVMVA
. || . . .      .  |...||...|. ||| |. ||.     |    |||| |.  . ....   .| .|||.|.|. | |.|||...| .|||. 
mlds.gesehtvtvgltssnkllnRfanivvyddnritLrpisghkDCtneyinAcyikgykekkq...yiatqgpvsntlvdFWkliwqekvtiivmlt

KLQEDGRSKCAPYWPSSDQGGlkTPSFVVEFVSQTSDDPYDRVILttELTLIHRLtNERRHVTHVQYLGWPDHG-VPDVDRFLALIDQVESLRAaHPRNM
. .|.|. ||  |||.||.       | .. ..... . | .  |  |..  .   .....||. |   |...| |..    | .| ...  .  .. | 
niieegkvkCqqYWpdsdtka..ygefsikllneetlneyierkl..evknknsa.gakqsvtqyqitnwdstgkvtnpqtillvieemyktqr.krgnt

YTLVHCSAGIGRTGVVVQTMAMLAILRRKRIPEAAAILRHLREQRARLVQTLQQYEFCFTAVLAKLK
  .||||...||..| . ..  .   . .   .  ..|...| |.  .||| |||.. |. ||  |.
sivvHCSdtvgrsavfcaaattinkcktegvidvfqvlksqRiqkpgsvqtvqqyqgifqivltyld
0041856 (Phosphotyrosine protein) phosphatases II 4368-4608 1.9e-43 143.5 In-house 1-171 (182) alignment 
Range on Protein: 4368-4608
Range on HMM: 1-171/182.0
NSTKNRYTDILAYDDTRvklrrgitGSDYINANYVTFPNEEAPfyFICAQGPTSQTVDDHWQLIWENDVRVIVMVAklqedgrskCAPYWPssdqgglkt
| .||||.||| || .|        ..||||||.. ..       ||..|||. .|| |......|.....||...         . .|||         
nldknrysdilpydhsr........dldyInanlylgslpatr..fiatqgpllstvadflrmlkelgittivnlt.........eelywp.........

psfvvefvsqtsddpydrviltteltlihrlTNERRHVTHVQYLGWPDHGVPDVDRFLALIDQVESlraahpRNMYTLVHCSAGIGRTGVVVQTMAMLAI
                               ... |......||.||||||||.| .|..|..|..      ..  .|||||||.||||..|    |.  
...............................ellerlgiqylylpwpDhgvpdldelldfieevle......eggpvlVHCsaGvgRtgtlvaaylmkkl

lrrkRiPEAAAILRHLREQRARLVQTLQQYEFCFTAVLAKL
    .   .  .....|..|   |.|..|| |.  |.| .|
....g.vsleeavklvrsrRpgmvitpnqyfflqlallell
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 4363-4605 4e-43 142.2 In-house 50-286 (305) alignment 
Range on Protein: 4363-4605
Range on HMM: 50-286/305.0
SSSRRNSTKNRYTDILAYDDTRVKLRRGItGSDYINANYVTFPNEEApFYFICAQGPTSQTVDDHWQLIWENDVRVIVMVAKLQEDGRSKCAPYWPSSDQ
 |.  . |||||.|. . | . ||| .    |||| ||||  |       |||||||  ||.|. | .. .| |  |||..|  | |. ||| ||| .  
qsadiaitknryqdvpcqdqsavkldkps.psdyihanyvgcpmipe.krficaqgpldqtidefwwmviqnkveqivmlcktvelgklkcaqywpaaqg

GGLKT-PSFVVEFVSQTSDDPYDRVILTTELTLIHRlTNERRHVTHVQYLGWPDHGVPDVDrflalIDQVESLRAAHPRNMYTLVHCSAGIGRTGVVVQT
  |.     ||| || .     |  |  | | | .   ...  | |.|.  ||| ||| .      .  .| | |    ..  .||||||||||| .|  
eklelksgivvenvsgskpmerdaeiqitllnltys.gdqkmsvrhlqwtewpdrgvppck.....ltslellsairgskvpivvhcsagigrtgtivai

MAML-AILRRKRIPEAAAILRHLREQRARLVQTLQQYEFCFTAVL
  .|  |   |. |    ... ||.|||  .|.  || |    .|
eyilekiaenkpcppmpelvkalrdqrafsiqndvqylfihrvml
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 4350-4608 6.4e-43 141.7 In-house 15-266 (283) alignment 
Range on Protein: 4350-4608
Range on HMM: 15-266/283.0
YDSIFRERQGGSFSSSRRNSTKNRYTDILAYDDTRVKLRRGITgsDYINANYVTF-PNEEAPFYFICAQGPTSQTVDDHWQLIWENDVRVIVMVAKLQED
.. .    .    .|...| .|||. .|...|  ||.|.      ||||| ...   ...    .| ||.|  .|| | |........  |||..|||||
lkrlsvpdldadiasadenkrknrnqeivpadqwrvelksesr..dyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfdekitaivmltklqed

GRSKCAPYWPSsdQGGLKTPSFVVEFVSQTSDDPYDRVILTTELTlihRLTNERRHVTHVQYLGWPDHGVPDVDRFLALIDQVESLRAAHPRNmYTLVHC
 | ||. |||.  .|  .   | |    .|. . . .  |.         ...   ..| |. .| . |   .   |  ...| ||.  ...    .|||
lrikCsqyWPk..rGsedyGeftvtlrkettsnsfiikelllrvn...ssakstlllahyqvidWleygeqaiinslvkfnkvislqteskkg.PivvhC

SAGIGRTGVVVQTMAMLAILRRKRIPEAAAILRHLREQRARLVQTLQQYEFCFTAVLAKL
|.|||||.| .  .| .  .. . . .  |... .||||  .||||.|| .  ..|| . 
stgiGrtavfiaasasvkdaltesvvdvfavvkimreqrmmavqtldqyklvhelvleqa
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 4363-4611 1.6e-42 140.5 In-house 42-281 (287) alignment 
Range on Protein: 4363-4611
Range on HMM: 42-281/287.0
SSSRRNSTKNRYTDILAYDDTRVKLRrgITGSDYINANYVTFPNEEApfYFICAQGPTSQTVDDHWQLIWENDVRVIVMVAKLQEDGRSKCAPYWPSSDQ
. . .|  |||.|.|| .|. || |.   .  ||||| ..   .|.    || |..| ..|. . |.||... | .|||.....|. ...|  |||... 
niasqnkdknRltqilvpdnyrvllk..gehpdyinavfidgykekk..afiiaesPmfntarnfWkliddrnvtaivmlcqekendeevcyqyWpeeks

ggLKTPSFVVEFVSQTSDDPYdrVILTTELTLIHRlTNERRHVTHVQYLGWPDHG-VPDVDRFLALIDQVESlRAAHPRNMYTLVHCSAGIGRTGVVVQT
  .    . .|.....  . |  .. . |..  .. ......|.  |.  |...| |..    | .|..       .. |   .||||...||... .  
..vvlGeyniellneevnagy..ierklevknknk.agdkqqvkqyqitnWdstgkvtepqtillvieemyk.tqrkrgntsivvhCsdtvGrsamfcaa

MAMLAILRRKRIPEAAAILRHLREQRARLVQTLQQYEFCFTAVLAKLKAA
   .   ..  . .   .|.. | |.   ||| .||.| . .||. |.. 
attinkckteGviDvfqvlksqriqkpgsvqtveqykfindivleyldsf
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 4367-4605 6.9e-42 138.3 In-house 2-236 (237) alignment 
Range on Protein: 4367-4605
Range on HMM: 2-236/237.0
RNSTKNRYTDILAYDDTRVKLRRGITGSDYINANYVTFpNEEAPFYFICAQGPTSQTVDDHWQLIWENDVRVIVMVAKLQEDGRSKCAPYWPSSDQGGlk
.|  |||| .| ||| .|| |.   .|||||||.|.    . .|  .|.||||   . || ||..|..   ||||.. | |  . ||  ||||.||    
enkiknrygnivaydhsrvvlkgagsgsdyinatylkg.fdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywpstdqpa..

tpSFVVEFVSQTSDDPYDRVILTTELTLIHRLTNERRHVTHVQYLGWPDHGVPDVDRFLALIDQVESLRAAH-PRNMYTLVHCSAGIGRTGVVVQTMAML
  .. |  || . .. .    . . |.  .   .| | .   |.  |||.|||.    |  . .    |. | ..    ..|||||.||||...   |||
..aygvltvslkkkeefsdytvrslllskrltlkevrlihqyqftswpdrgvpqqtaallrfrkniinrsphvsesgpwiihcsagvgrtgiflvidaml

AILRRKRIPEAAAILRHLREQRARLVQTLQQYEFCFTAVL
   . |.. .    .  . |.|  ..|| .|| | . ..|
rqakekkvvdiynyvysieedrpyiiqtkdqyvfihqtil
0051429 (Phosphotyrosine protein) phosphatases II 4392-4608 6.1e-41 136.2 In-house 2-225 (272) alignment 
Range on Protein: 4392-4608
Range on HMM: 2-225/272.0
TGSDYINANYVTFPneeapF------YFICAQGPTSQTVDDHWQLiWENDVRVIVMVAKLQEDGRSKCAPYWPSSDQ-------GGLKTPSFVVEFVSQT
  |.||||..|  .     .      ......||.  |..| |.| .|.....||.. .. | || || .|||  .         .  |...   .|  .
plsgyiNardvggy.....grvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtll

SDDPYDRVILTTELTLIHRLTNERRHVTHVQYLGWPDHGVPDvDRFLALIDQVESlraahprNMYTLVHCSAGIGRTGVVVQTMAMLAILRRKRIPE---
|   .. .||.. |  ..  ..| |.|.| .|..|||||||. . .|.|.... .       .   |||||||..|||.||    .|. . .  | .   
seellldyilrellltlllsagearevmhlhytdwpdhgvpq.eallellellld.......ggpvlvHCsaGkdRTGtvvallllllgvsletivddYl

-----AAAILRHLREQRARLVQTLQQYEFCFTAVLAKL
     .......||.||.  ||| .||.|.. |.|. |
ltnlyleeaveelraqrpgavqteeqylflyeallell
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 4367-4606 6.5e-41 135.0 In-house 47-285 (305) alignment 
Range on Protein: 4367-4606
Range on HMM: 47-285/305.0
RNSTKNRYTDILAYDDTRVKLrRGITGSDYINANYVTFPNEeaPFYFICAQGPTSQTVDDHWQLIWENDVRVIVMVAKLQEDGRSKCAPYWPSSDQGGLK
... |||| |.   |. |||| .|    .|| ||||. | .  |  |||.| |  .|  | | . ... |  | |. .|.| |  ||. |..| |.  |.
qeagknrykdvgcldnnrvkl.egpwpheyihanyvstptn..pkrfictqaplektcadfwymclqdkveaifmlcnllekgakkcleyfaskdkdvle

----TPSFVVEFVSQTS---DDPYDRVILTTELTlIHRLTNERRHVTHVQYLGWPDHGVPDVDrfLALidqVESLRAAHPRNMYTLVHCSAGIGRTGVVV
        .| | | ..    .. . ..  |.|. |    .. |.|||  .  ||| |||  |  ||.   .| |  | |    . ||||||||||| ||
feekgqkisvkfessvtlkfrkdakakvtetvlv.iegpgekarkvthyhwidwpdrgvpaad..lai...lellekarpskgpivvhcsagigrtgsvv

QTMAML-AILRRKRIPEAAAILRHLREQRARLVQTLQQYEFCFTAVLA
    .|  .|  . | ..  ||...||||   .|| .|| |    .| 
mleyildqllagqiiedtdkilqkireqrnnsiqtdaqylfvhqviln
0049772 (Phosphotyrosine protein) phosphatases II 4364-4608 7.2e-41 136.3 In-house 42-280 (314) alignment 
Range on Protein: 4364-4608
Range on HMM: 42-280/314.0
SSRRNSTKNRYTDILAYDdTRVKL-RRGITGSDYINANYVTFPneeapFYFICAQGPTSQTVDDH----------WQLI--WENDVRVIVM---------
.  .| .||||.||| .| .||.| . .. |||||||.||  .       ||..|||.. ||.|           |...  ....||.|||         
dlflnrdknryldilpad.nrvilpglpvsgsdyinasyvdgf.....lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivmsrdevlade

------------VAKLQEDGrskcaPYWPSSDQGGLKtpsfvvefvsqtsDDPYDRVILtteltlihrltneRRHVTHVQYLGWPDHGVPDVDRFLALID
              .| . |     .... .|.  ||             .  ||.  .              |.. .. .. .||...|. . |.....
lsrLdaAlgKtpllildgng.....neptaadlellk.............eelydpelf.............erlgikylripvpDgsaplledfdefle

QVESLraahPRNMYTLVHCSAGIGRTGV-VVqtmaMLAILRRKRIpEAAAILRHLREQRA-----RLVQTLQQYEFCFTAVLAKL
 .|..    ...  .||||.||.||||. ||    .  .... ..  .. .|...|..|      .....|.||||.. |.| .|
fieea....dkggpvlvHCkaGkgRtgtfvv....aaylmkllgv.sleealedvrlkRpinpnpgfieqleqyefilealleyl
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 4366-4609 7.7e-41 135.0 In-house 47-280 (315) alignment 
Range on Protein: 4366-4609
Range on HMM: 47-280/315.0
RRNSTKNRYTDILAYDDTRVKL--RRGITGSDYINANYVTFPNeeAPFYFICAQGPTSQTVDDHWQLIWENDVRVIVMVAKLQEDGRSKCAPYWPSSdqg
  |  |||| .|.||| .||.|       .|||.|||..   |   .  .|.||||  ..|.| |.|..|.|.  |||...| |. ..|.  |||     
ienkqknryiniiaydksrvqlpllendphsdyvnanfidGyn..kkrryiaaqgpnvasvkdfwrlvfeedigkivmltnlvegekrkaekywpdk...

glkTPSFVVEFVSQTSDDPYDRVILTTEltlIHRLTNERRHVTHVQYLGWPDHGVPDVD-RFLALIDQVESLRAAHPrnMYTLVHCSAGIGRTGVVVQTM
      .    |.. |.. ....   |         .. |.|  ..|  ||| |||     .. || .|   . .       .||||||.||||  .   
...kviyGkitvtrkseevnteytvrtl...svvfgdnirevvqlhytswpdmgvpkytiplmnlirtvkqhhtnsv..gaivvhcsaGvGrtGtfitld

AMLAILRRKRIPEAAAILRHLREQRARLVQTLQQYEFCFTAVLAKLK
|.|  .  ... .   ... .|..| ..||...||.| . |.|  . 
avldqaeaenaidvynfitgvrqnrikmvqvaeqyqfiydalletfv
0036282 (Phosphotyrosine protein) phosphatases II 4393-4601 7.9e-41 135.0 In-house 1-163 (174) alignment 
Range on Protein: 4393-4601
Range on HMM: 1-163/174.0
GSDYINANYVTFPNEEApfYFICAQGPTSqtvddHWQLIWENDVRVIVMVAKLQEDGRSKCAPYWPSsdqgglktpsfvvefvsqtsddpydrvilttel
|||||||... .       ..|. |||..     .|....|......||. ...|.|. ||  |||.                                 
gsdyinaspldlsyitp..rliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe.................................

tlihRLTNERRHVTHVQYLGWPDHGVPDVDRFLALIDQVESLRAAhPRNMYTLVHCSAGIGRTGVVVQTMAMLAILRrKRIPEAAAILRHLREQRARLVQ
    . . ..|.. ...||.||||||||.. .| ....||. ..  ...  .|||||||.||||..|  . ||  |.  .  .| ...| || || . ||
....lredlerlgiqylylpwpDhgvpdlsillefvkfveealse.dpggpvlVHCsaGvgRtGtlvaaylmlrgll.eslvdaldlvrelRlqrpgmvq

TLQQYEFCF
| .||.|. 
tpsQyrfly
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 4368-4606 1.3e-39 130.6 In-house 56-281 (290) alignment 
Range on Protein: 4368-4606
Range on HMM: 56-281/290.0
NSTKNRYTDILAYDDTRVKLRRGITGsDYINANYVTFPNeeAPfyFICAQGPTSQTVDDHWQLIWENDVRVIVMVAKLQEDGRSKCAPYWPSSDQGGLKT
. .|||| |.   | ||| |. |  | ||. ||||   .  |.  || .||.. .|| | |... ...| .|||. .| |||..||..|.|  .   |  
efkknrykdvvcndktrvilkdGydG.dyvhanyvkGlk..am..filtqGalkdtvidiwrmvlqekvaaivmlceliedGkakceqyypekeGevltf

PSFVVefvSQTSDDPYDRVILTTELTLIHRLTNERRHVTHVQYLGWPDHGVPDVDrfLALIDQVESLRAAHPRnmyTLVHCSAGIGRTGVVVQTMAMLAI
 .. |     . .|  |  |    |.. .. .     . |..   |||. |.  .  |||.  . .|| |        |||||||||||  |   . | |
Geitv...lcseeddkdaniikktlsvrdkdsGkehklkhlkikswpdksvalst..lallrtlrilrkasGp...vvvhcsaGiGrtGtfvaievglqi

LRRKRIPEAAAILRHLREQRARLVQTLQQYEFCFTAVLA
|   .  . . . | ||. |.  ||   ||     ..| 
lldGkeldlldlvralrnsrlnsvqvdiqylalveilld
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 4364-4603 5.9e-39 128.9 In-house 37-272 (307) alignment 
Range on Protein: 4364-4603
Range on HMM: 37-272/307.0
SSRRNSTKNRYTDILAYDDTRVKLRRGITGSDYINANYVTFPNeeAPFYFICAQGPTSQTVDDHWQLIWENDVRVIVMVAKLQEDGRSKCAPYWPSSDQG
. . |. ||||.|. . | .|. ..     |||| |||.       |  |||||||  .|. . | .. ...|  ..|..|. | .. ||  |||  .  
afsantdknryqdvkcqdkgrivvkfdglasdyihanylgiai..kpkkficaqgplentqysfwamaiqekvesvimlckvielakikceqywpleegq

----GLKTPSFVVEFVSQTSDDPYDRVILTTELTLIHrlTNERRHVTHVQYLGWPDHGVPDVDrfLALIDQVESLRAAhprNMYTLVHCSAGIGRTGVVV
    | .. .  |. .      | . .|  |.| .    ... | ..|.|.  |||.|||...  |. |. .|. |     .   .||||||.||.| .|
klvfgeapntisvanlgakklapdedlinvttlkvdw..aqksrtiqhlqwenwpdrgvpqin..ltainlleavryd...tnpvvvhcsaGvGrsGtiv

QT-MAMLAILRRKRIPEAAAILRHLREQRARLVQTLQQYEFCFTA
   . .  ... .   .   ... ||.||   .||  || .    
aislvqdkmiaGinckdmkklveelrsqrhyaiqteaqylylhrv
subfamily_ptpA1_pd Subfamily ptpA1 4364-4567 7.2e-39 128.7 In-house 43-255 (418) alignment 
Range on Protein: 4364-4567
Range on HMM: 43-255/418.0
SSRRNSTKNRYTDILAYDDTRVKLRR--GITGSDYINANYVtfpNEEAPFYFICAQGPTSQTVDDHWQLIWENDVRVIVMVAKLQEDGRSKCAPYWPSSD
  ..|..|||||.||  . |||.|..     |||||||||.   .   |  |||.|||  .|. | |...||| .|.|||...  |. | ||  |||   
dkkhntsknrytnilpvnhtrvqlkkiqdkegsdyinanyi...dgaypkqfictqgplpntiadfwrmvwenrcriivmlsresencrikcdrywpeqi

QG---------GLKTPSFVVEFVSQTsDDPyDRVILTTELTLIhrLTNERRHVTHVQYLGWPDHGVPDVD-RFLALIDQV----ESLRAAHPRNMYTLVH
 |              .. ||.|    .|| .| |.| .. |   .  | | .|. || ||||| .||    |  |.  .    . .  .  ||.  .||
ggeqfsiygngnevfgtysvelvevi.qdp.ereiitrnirlt..fegetrditqyqyegwpdhnipdhtqpfrqllhsitnrqnqiipssdrnvpiivh

CSAGIGRTGVVVQTMAMLAI
||||.|||| .. .. |.  
csagvgrtgtfctavimmkk
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 4365-4608 9.6e-38 124.6 In-house 42-236 (392) alignment 
Range on Protein: 4365-4608
Range on HMM: 42-236/392.0
SRRNSTKNRYTDILAYDDTRVKL--RRGITGSDYINANYV-TFPNEEApfyFICAQGPTSQTVDDHWQLIWENDVRVIVMVAKLQEDGrskcapywpssd
   |  |||| .|| || .||||     |. |||.|| |. .| ||.|   .|..||| . ..|| |.......|  |.||.||.|              
keinlkknryknilpydsarvkleviddipdsdylnasyipsfdneka...yiasqgpnaaslddfwrmvfqenvttiamvtklkegd............

qgglktpsfvvefvsqtsddpydrviltteltlihrLTNERRHVTHVQYLGWPDHGVPDVDRflALIDQVESLRAAHPRNM-YTLVHCSAGIGRTGVVVQ
                                      .. | |.  ..  |||..||      .|.  .. ..| . .     ..|||||.||||||. 
....................................kgddartvaqfhftewPdkdvpkhts..sllkfikevkadfGqythpliihcsagvgrtgvvis

TMAMLAILRRKRIPEAAAILRHLREQRARLVQTLQQYEFCFTAVLAKL
  ...|  .. |. .   ..  .|..|  .||| .|| | . |||  |
idsvvahakktrmvdvfnfvtnirrkrpymvqtkeqyafiygavledl
0046846 (Phosphotyrosine protein) phosphatases II 4388-4605 2.1e-37 123.9 In-house 6-170 (176) alignment 
Range on Protein: 4388-4605
Range on HMM: 6-170/176.0
RRGITGSDYINANYVTFPneeapfYFICAQGPTSQTVDDHWQLIWENDVRVIVMVAKLQEDGRSKCAPYWPSSDQGGLktpsfvvefvsqtsddpydrvi
.    ..||||||..  .      ..|. |||. .|. | .....|......|.. ...| || ||. |||   . |.                      
lgldldldyinanlilgs......rpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgi......................

ltteltlihrltnerrhvtHVQYLGWPDHGVPDVDRFLALIDQVESLRAAHprnMYTLVHCSAGIGRTGVVVQTMamlaILRRKRIPEAAAILRHLREQR
                   ....|.|||||||| . .| |...... . ..     .||||||||||||..|       .|....   .  .|...||||
...................qylhlpwpDhgvpdlelllellefirealkeg...gpvlVHCsaGigRtgtlvaay....llelekglsveealalvreqR

A-RLVQTLQQYEFCFTAVL
  . ||| .||.|.  ..|
plgavqtpeQyrflyefel
0043147 (Phosphotyrosine protein) phosphatases II 4393-4601 4.2e-37 122.9 In-house 4-154 (172) alignment 
Range on Protein: 4393-4601
Range on HMM: 4-154/172.0
GSDYINANYVTFPNeeAPFYFICAQGPTSQTVDDHWQLIWENDVRVIVMVAKLqedgrskcapywpssdqgglktpsfvvefvsqtsddpydrvilttel
|||||||.|. ..    |  ||. |||.. |..|.|....|.....||.. .|                                               
gsdyinasyldlyy..ipdrfiatqgplrntladfwrmlkelgithivnltel...............................................

tlIHRLTNERRHVTHVQYLGWPDHGVPDVDRFLALIDQVESLRaAHPRNMYTLVHCSAGIGRTGVVVQTMAMLailrrKRIpEAAAILRHLREQRARLVQ
   .  ... |.. ...||.|||||||. . .| .......|  |  ..  .|||||||.||||..|    ||     ...  .  .....||.|   ||
..lydpellerlgiqylylpwpDhgvpllellleflefidell.alspggpvlVHCsaGvgRtgtlvaaylml.....lgl.sleeavalvrekRpgavq

TLQQYEFCF
. .|| |. 
npsqyrfly
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 4367-4609 2.6e-36 120.1 In-house 42-272 (288) alignment 
Range on Protein: 4367-4609
Range on HMM: 42-272/288.0
RNSTKNRYTDILAYDDTRVKLRrgITGSDYINANYVTfpNEEAPFYFICAQGPTSQTVDDHWQLIWENDVRVIVMVAKLQEDGRSKCAPYWPSSDQGGLK
 |.|..||...   | |||||        ||.|| |.   .. .  .|||| |   |..  |... |.||. |||...| | |. | | |.||      .
anptrdryenlprcditrvkls..ddpdfyiaanvvs..sakykrrlicaqaPlngtieelWkmllesdveyivmlcellekGkeksaeyfPsklGekar

TPSFVVeFVSQTSdDPYDRVILTTeLTLIHRLTNERRHVTHVQYLGWPDHGVPDvdRFLALIDQVESLRAAH-PrnmyTLVHCSAGIGRTGVVVQTMAML
   .    | .   .  |...  . |  |.. ..|.  | .. .| |.|.|||.   .|. .  .| |.. . |     .||.|||.|||| .. .. .|
igrlct.vvkkkr.adidklvkvs.llriskegeekvivkilhlleWdddgvPe..nylsplrllevlkslqkP....ivvhssaGvGrtgtlililial

AILRRKRIPEAAAILRHLREQRARLVQTLQQYEFCFTAVLAKLK
  || .       .| .|||.| . .|| .|| . .  || .| 
eslrlddflgirsllaklreerfkaiqtemqylyvhrcvleell
subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 4367-4605 1.2e-34 114.3 In-house 36-266 (281) alignment 
Range on Protein: 4367-4605
Range on HMM: 36-266/281.0
RNSTKNRYTDILAYDDTRVKLRR---GITGSDYINANYVTFPNEEAPfyFICAQGPTSQTVDDHWQLIWENDVRVIVMVAKLQEDGRSKCAPYWPSSDQG
 |  ||||..| . | .||.|.        .||| |||.  |  .    .| .|||  .|  | |..||...   |||.... |  | ||| |.|   . 
vnnkknrylnipcldisrvqlkvkmpnknstdyihanyirspflkrg..yiltqgpkketradfwrmiwqenttaivmlcqfletnrekcaeyfprnahc

GLKTPSFVVEFVSQTsddpYDRVILTTELTLIHrlTNERRHVTHVQYLGWPDHGVPDVDRFLALIdqvesLRAAHPRNMYTLVHCSAGIGRTGVVVQ-TM
 |.   . |..   |     .. ..|| | | .    | | .||  .  |||  ||.    .  |     ||  . |    ..|||||.||.| ..   .
clqfdklsvsyedst....vnkslvttrlnlsy..egetrlithwlwkewpdwqvpessevmlki.....lrkirarstppvihcsagvgrsgtlmavei

AMLAILRRKRIPEAAAILRHLRE-QRARLVQTLQQYEFCFTAVL
|. .|  .  .|.   |. |||   ||  ||||||| . .  .|
alqsihshftlpdikqivshlrvtgraasvqtlqqymliwkvll
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 4366-4606 1.5e-34 114.6 In-house 46-286 (325) alignment 
Range on Protein: 4366-4606
Range on HMM: 46-286/325.0
RRNSTKNRYTDILAYDDTRVKLR--RGITGSDYINANYVTFPNEEApfYFICAQGPTSQTVDDHWQLI--WEndVRVIVMVAKLqEDGRSKCAPYWPSSD
  |  |||. ...|.| .|| |   .  . ||||||.|.    .     |. || | ..|..| |.|.  |.    |.|.. .| . |  .|| |||   
penkaknrfknvvaldksrvvletkkddpssdyinasylrddkkkd..vflaaqaPltatindlWrlvldWr..csvvvvlnel.dlgkdrcavywpkem

QGGLKTPSFVVEFVsqTSDDPYDRVILTTELTliHRLTNERRHVTHVQYLGWPDHGVPDVDRFL----ALIDQV-ESLRAAHPRNMYTLVHCSAGIGRTG
    .  .. |...  | ..  | |    ..        | | |   |. .|.| ||.     |     |...| | ..|        |||||||.||||
gksktfGglevklr..tieeisdyvhrvldvk..qvkkGetrsvkqfqlqswddmGvqkrpatlisilqlvkavservtantkastpilvhcsaGvGrtG

VVVQTMAMLAILRRKRIPEAAAILRHLREQRARLVQTLQQYEFCFTAVLA
| .   ..|| .  .   .    ...||..|  .|.|  || ....|.  
vfislysalakvieesrvdifgfvkklrkdrpsmvetvdqyiliyealve
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 4344-4609 2.9e-34 113.1 In-house 15-294 (301) alignment 
Range on Protein: 4344-4609
Range on HMM: 15-294/301.0
KEAANTYDSIFRERQ-GGSFSSSRRNSTKNRYTDILAYDDTRVKLRRG----ITGSDYINANYVTFPNEEApfYFICAQGPTSQTVDDHWQLIWENDVRV
.. .. |... ....   . . | .|.. ||. .|  ||| |. |.      ..  .||||.|.   .|.    || ||||  .|. | |.|||.. .  
nkfeeqykelkegedksctvglseenkalnrfknitvyddnriilkpkpnldlcqreyinasyidgysekk..kfiaaqgpmkktlvdfWrliwqekpvs

IVMVAKLQEDGRSKCAPYWPSSDQGGLKTPSFVVEFVSQTSD-DPYDRVIL----------TTELTLIHRLTNERRHVTHVQYLGWPDHGV-PDVDRFLA
||||..|.|. .|||  |||.|..   .   | |..|...   |   | .            .| ..  . ... ..|. .|   ||..|| ..    | 
ivmvtnlkegtkskceqywpnseaeseefgpftvtlvneqvyPdfvirqlnvkiqdgsnngyierkfkvksdksswdvlqlqvtdWpqdGvvreprtvLq

LIDQVeSLRAAHPRNMYTLVHCSAGIGRTGVVVQTMAMLAILRRKRIPEAAAILRHLREQRARLVQTLQQYEFCFTAVLAKLK
 ||.|   |   .     .||||....|.|| .     |   ..  . .   . . .| ..   |.||.|| . . ..   |.
viddv.ihrqqkigggpvvVHCSdtVsrsGvYcsvsiglEQckaegVVdvfqvtkavrrskpgaVtTLeqytsiydvidmylq
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 4363-4610 3.8e-34 112.9 In-house 43-281 (439) alignment 
Range on Protein: 4363-4610
Range on HMM: 43-281/439.0
SSSRRNSTKNRYTDILAYDDTRVKL--RRGITGSDYINANYVTFPNEeaPFYFICAQGPTSQTVDDHWQLIWENDVRVIVMVAKLQEDGRskcapYWPSS
 .   . ||||| |. |.| ||| |    |.  | ||||||.    .  .  .| .|||. .|.|| |.|..|. .  |||...| |  .     ||||.
aaqeydqtknrykdvgafdhtrvtlqeipgvphshyinanyikGyyd..dklyiatqgpkkettddfwrlviekktvtivmltnlvesyk.....ywpsd

DQGGLKtpSFVVEfVSQTSDDPyDRVILTTELTLIHRLTNERRHVTHVQYLGWPDHGVPDVDRFLalIDQVESLRAAHPRNMY--TLVHCSAGIGRTGVV
..        .|  | .  . | . ||    .   .  |.  | | ...|. |||. ||    ..  .| . .. .|  .. |   .||||||.|||| .
aevcyg..diavr.vdrnielp.nyvirgfkvfnerdttekertvlqfhyiawpdknvpaqashv..ldflrainsandkeeygpvvvhcsagvGrtGti

VQTMAMLAILRRKRIPEAAAILRHLREQRARLVQTLQQYEFCFTAVLAKLKA
.     |  |. .   .   |.. ||.|| ..||.| || | . |||  .. 
ialdialeqlklenkvdikgivkvlrkqrkqmvqalcqyvfiynavledivy
0049260 (Phosphotyrosine protein) phosphatases II 4410-4601 4.1e-33 109.6 In-house 8-143 (152) alignment 
Range on Protein: 4410-4601
Range on HMM: 8-143/152.0
PFYFICAQGPTSQTVDDHWQLIWENDVRVIVMVAKLQEDGRSKCAPYWpssdqgglktpsfvvefvsqtsddpydrviltteltlihrltnerrhvtHVQ
||.||..|||...|..|.|....|.....|||. .|.|.|. ||. |.                                                 ...
pfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi.................................................qyl

YLGWPDHGVPDVDRFLALIDQVESLRaAHPRNMYTLVHCSAGIGRTGVVVQTMAMLailrrkRIPEAAAILRHLREQRARLVQTLQQYEFCF
.| |||||||| . .|  . ..   . |. ..  .|||||||.||||..|    ||      .  ..  .....||.|   |.. .|..|..
hlpwpDhgvpdlsqlllflllfiekl.aldkggpvlVHCsaGvgRtgtlvaaylml......lgvsleeavalvrekRpgavpnpgqlrfly
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 4365-4605 5.3e-33 109.1 In-house 4-237 (239) alignment 
Range on Protein: 4365-4605
Range on HMM: 4-237/239.0
SRRNSTKNRYTDILAYDDTRVKLRRGI--TGSDYINANYVTfPNEEAPFYFICAQGPTSQTVDDHWQLIWENDVRVIVMVAKLQEDGRSKCAPYWPSSDQ
 | | .||||..|..|| .|| | .      ||||||.|.    . .|  .|..||  . .  | |...|..   ||||.. | |  . ||  ||| |  
krvnkaknryanivtydhsrvvleklsndphsdyinasylr.dydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdsts

gglKTPSFVVEFvsQTSDDPYDRVILTTELTLIHRltNERRHVTHVQYLGWPDHGVPDVDR-FLALIDQVesLRAAHPRNMYTLVHCSAGIGRTGVVVQT
   |   . | .  . ..   | .| |  .. . .   | |.| . ..  |||.|||.     | |  ..   . . |     ..|||||.|||| ..  
...kycnlrvtl..rktevfadyiirtfvmsqvgq..teeryvyqyhftvwpdkgvpqyatavlglrrki..tkdslpgarpwvihcsagvgrtgaflvi

MAMLAILRRKRIPEAAAILRHLREQRARLVQTLQQYEFCFTAVL
 |||   ....  .    .. .||.| ..||| .|| | . |||
damlrqakkqktvdifnyvkairedrphmvqtseqyvfihlavl
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 4365-4605 6.1e-33 109.0 In-house 5-238 (239) alignment 
Range on Protein: 4365-4605
Range on HMM: 5-238/239.0
SRRNSTKNRYTDILAYDDTRVKLRRGI--TGSDYINANYVTfPNEEAPFYFICAQGPTSQTVDDHWQLIWENDVRVIVMVAKLQEDGRSKCAPYWPSSDQ
 | | .||||..|..|| .|| | .      ||||||.|.    . .|  .|..||  . .  | |...|..   ||||.. | |  . ||  ||| |  
krvnkaknryanivtydhsrvvleklsndphsdyinasylr.dydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdsts

gglKTPSFVVEFvsQTSDDPYDRVILTTELTLIHRltNERRHVTHVQYLGWPDHGVPDVDR-FLALIDQVesLRAAHPRNMYTLVHCSAGIGRTGVVVQT
   |   . | .  . ..   | .| |  .. . .   | |.| . ..  |||.|||.     | |  ..   . . |     ..|||||.|||| ..  
...kycnlrvtl..rktevfadyiirtfvmsqvgq..teeryvyqyhftvwpdkgvpqyatavlglrrki..tkdslpgarpwvihcsagvgrtgaflvi

MAMLAILRRKRIPEAAAILRHLREQRARLVQTLQQYEFCFTAVL
 |||   ....  .    .. .||.| ..||| .|| | . |||
damlrqakkqktvdifnyvkairedrphmvqtseqyvfihlavl
subfamily_CG7180_pd Subfamily CG7180 4366-4605 5.6e-31 102.3 In-house 40-287 (296) alignment 
Range on Protein: 4366-4605
Range on HMM: 40-287/296.0
RRNSTKNRYTDILAYDDTRVKLRR--GITGSDYINANYVTFPNEEAPfyFICAQGPTSQTVDDHWQLIWENDVRVIVMVAKLQEDGRsKCAPYWPSSDqg
  |  |||. ... || .|| |..  |   |||||| ||     ..   .|  ..|. .|||..|.|......  .|...|  .  . ..  |||     
kenreknrdvkvvPyDynRvvLekldGeeksdYinavyvdsflkkke..yivteapkketvdefWrlvydeeisavvvLtktfdfak.mypsywpnks..

GLKTPSFVVEFVSQTSDDPYDR--VILTTE----LTLIHRLTNERRHVTHVQYLGWPD-HGVPDV-DRFLALIDQVESLRAAH---PRNMYTLVHCSAGI
  .   ..|| |.. .        . || .        .  . | | |...|.  |.  . || .   .. |. .|...|      | .  ..|..| | 
keqygeifveiveekqyanlkirtfkltkkivalteqekqvkaetRivklfqlteWeledkvPlstnalielrrrvrlwrekvdedpeegPvvvvssdGa

GRTGVVVQTMAMLAILRRKRIPEAAAILRHLREQRARLVQTLQQYEFCFTAVL
.|.|| .   | |  ....   .    .. ||..| .||.. ..| ...  .|
sRsGvylaidanlelvekeeevdvFeavktlrrsRpqLvenveeYkyiYdvll
subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 4361-4600 6.9e-31 101.9 In-house 45-282 (310) alignment 
Range on Protein: 4361-4600
Range on HMM: 45-282/310.0
SFSSSRRNSTKNRYTDILAYDDTRVKLRRGIT-GSDYINANYVTFPNEEApfYFICAQGPTSQTVDDHWQLIWENDVRVIVMVAKLQEDGRSKCAPYWPS
.. . ...  ||||.|..  |..||||.   .   ||| ||||      .   |||.|||  .|. | |..|...    |... |  |.|| ||  ||||
tyeaykkymhknrysdvvcldtsrvklkidksryedyihanyvktnylrs..tficsqgplqhtiidfwrmifqeraesilllckvgeegrpkcvgywps

SDQGGLKTPsFVVEFVSQTSDDpYDRVILT-----TELTLIHRLTN-ERRHVTHVQYLGWPDHGVPDVDRFlalidQVESLRAAHPRNMYTLVHCSAGIG
            |  .|..|.. .. . |.      .. .  . .| .   |. ...  ||| ||||          |     |  |    .||||||..
lgvtetygc.irvtnlsessee.feicnlavtfvpdnvpvdeqpanlkelrvslikwpnwpdrgvpdekch.....tvpqrllaqvrhgpcvvhcsagkd

RTGVVVQTMAMLAILRRKRIPEAAAILRHLREQRARLVQTLQQYEFC
|..|||.    .  |.|    .|  .  .|. .||  .||  || . 
rlyvvvalklkidkldrglkvdaeevktellksraiciqtelqylii
0044763 (Phosphotyrosine protein) phosphatases II 4387-4602 1.1e-29 98.7 In-house 11-165 (178) alignment 
Range on Protein: 4387-4602
Range on HMM: 11-165/178.0
LRRGITGSDYINANYVTfpneeaPFYFICAQGPtsqtvDDHWQLIWENDVRVIVMVAKLQEDGRSKCAPYWPSSDQgglktpsfvvefvsqtsddpydrv
 ..|. .||||||....      |........|      |...|..|.....||.... .| |. || ||||..                          
nleglersdyinaseil......pglylgslpp.....addlellkelgithivnlteelelgflkcdpywpeeag........................

iltteltlihrltnerrhvTHVQYLGWPDHGVPD-VDRFLALIDQVESLRAahPRNMYTLVHCSAGIGRTGVVVqtmaM----LAIlrrkRIpEAAAILR
                    .......|||||||  . ||.... .|....  ...  .|||||||.||.|..|    .    .      ..  . ....
...................iqylhipipDhgvpdllehflefvefieeald..ekggpvlVHCsaGvgRsgtlv....aaylmkkl....gl.sleeaie

HLREQRArLVQTLQQYEFCFT
..||.|   |..  |....  
lvrerRp.ivpnpgqlrqLye
0051082 (Phosphotyrosine protein) phosphatases II 4394-4603 9.3e-29 95.4 In-house 3-148 (151) alignment 
Range on Protein: 4394-4603
Range on HMM: 3-148/151.0
SDYINANYVTfPNeeapfyFICAQGPTSqtvdDHWQLIWENDVRVIVMVAKLQEDGrsKCAPYWPSSDqgglktpsfvvefvsqtsddpydrvilttelt
|||||..||| ..      ... .||..    |...|..|.....||.. ...| |  .|. |.|. .                                
sdyinfsyvt.gg......lyrsggpla....dflellkelgiktivnlrseeerg..ycpeylpelg................................

lihrltnerRHVTHVQYLGWPDHGVPDV-DRFLALIDQVESlraahPRNMYTLVHCSAGIGRTGVVVQTMAMLaiLRrkriPEAAAILRHLREQRARLVQ
         ..|.|...|.|||.|.|.  | .|........     ..|  .|||||||.||||..|  . ||  |.      ....|...|..|  .||
.........ievlhipildwpdpglplsfdavleflellld.....kkngpvlvHCsaGkgRTGtlvalylml..lg....vsleealeeyrlkrpgvvq

TLQQYEFCFTA
. ||. |.. |
pnqqflfqlfa
subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 4371-4609 2.4e-27 90.5 In-house 46-277 (312) alignment 
Range on Protein: 4371-4609
Range on HMM: 46-277/312.0
KNRYTDILAYDDTRVKLRRgiTGSDYINANYVTFPNEeaPFYFICAQGPTSQTVDDHWQLIWENDVRVIVMVAKLQEDGRSKCAPYWpsSDQG---GLKT
 ||| .|  .|  |  |        || ||.|       |  |.|.|||  .|.   |||        |.... . |||  ||| |   ||      |. 
lnrypniqcwdrgrftlag..denfyihanfvkictk..perfvctqgplentcthfwqlalslgstsiillcgfvedgsekcakyi..sdivgfvdled

PSFVVEFVSQTSD--DPYDRvILTTELTLIHRLTNERRHVTHVQYLGWPDHGVPDV-DRFLALIDQVEslraahPRNMYTLVHCSAGIGRTGVVVQTMAM
     |....        |. |    | .. . | .  .. | |.  |||||.||  |  | |.  |         .   . |||||.|||| ..   .|
hrvyteycteieiggkskdk.ithrvlkvvvkatgqesklnhyqwaswpdhgmpdscdtalrllsavk......kdkkpviahcsagvgrtgtlaliesm

LAILRRKRIPEAAAILRHLREQRARLVQTLQQYEFCFTAVLAKLK
.| ||  |  .   ..  || .||| |... || ... .||  | 
iaalrhprkqnvkdsfvllrkdrarsvrvfpqyvyalrcvlefly
subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 4366-4604 9.8e-27 88.6 In-house 33-266 (285) alignment 
Range on Protein: 4366-4604
Range on HMM: 33-266/285.0
RRNSTKNRYTDILAYDDTRVKLRRgiTGSDYINANYVTFPNEEAPFYfICAQGPTSQTVDDHWQLIWENDVRVIVMVAKLQEDGRSKCAPYWPSSDQGGL
  |   |||.|. . ..||| |.      ||| |... .| ..   | | .|||  .|. | |..|... .  ..|.. | | |  ||| |.|      .
eanpdlnryadvrcieetrvvlkn..hdrdyihaswmrmpgkdqsty.ittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekcalyypeklgevv

KTPSFVVEFVSqTSDDPYDRVILT-TELTLIHRLTNERRHVTHVQYLGWPDHGVPDVDRflALIDQVESLRAAHPRNMYTLVHCSAGIGRTGVVVQ-TMA
|   . . .     ..     ||    ..     ..|  .. |||   |||.  |.  |   .|.  . ..   |..    ||||||.|||  .|    |
kfgkyeitlte.ckeeaiagtilnaltvintedasseplymnhvqvpwwpdqlapedar..pmielykwvkkvnpkekpicvhcsagvgrtatfvgidya

MLAILRRKRIpEAAAILRHLREQRARLVQTLQQYEFCFTAV
 . |.    | |   |.| .|  | . ||.  |. | .  .
tirimenpni.emldivremramrfqavqshmqflflyvvl
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 4363-4461 1.2e-25 85.0 In-house 42-154 (350) alignment 
Range on Protein: 4363-4461
Range on HMM: 42-154/350.0
SSSRRNSTKNRYTDILAYDDTRVKLRR----------GITGSDYINANYVTFP----NEEAPFYFICAQGPTSQTVDDHWQLIWENDVRVIVMVAKLQED
|.  .  .||||..|| |. .||||..           . ..|||||||.  .    . .. | .| .|.|. .|||| ...| .|.|.||.......| 
seGvelfaknrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvkvilsltsdvel

GRSKCAPYWPSSD
.. ||  ||.  .
nlekcyrYWqegs
PTPc_DSPc_SM00012 4505-4605 9.4e-25 82.2 In-house 2-104 (105) alignment 
Range on Protein: 4505-4605
Range on HMM: 2-104/105.0
VTHVQYLGWPDHGVPD-VDRFLALIDQVESLRAAHPRNMYTLVHCSAGIGRTGVVVQTMAMLAILRRK-RIPEAAAILRHLREQRARLVQTLQQYEFCFT
|.|..|.||||||||. .| .| |...|.. . .. ..  ..||||||.||||..|    .|  |... . ..   |...||.||...|||..|| |. .
vkhyhytgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqylflyr

AVL
|.|
all
subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 4371-4597 2.8e-24 80.4 In-house 53-270 (301) alignment 
Range on Protein: 4371-4597
Range on HMM: 53-270/301.0
KNRYTDILAYDDTRVKLRRGITgSDYINANYVTFPneEAPFYFICAQGPTSQTVDDHWQLIWENDVRVIVMVAKLQEDGRSKCAPYWPSSDQGGLKTPSF
|.||  .    .| |..    .    | ||..  .    |  ||..||| ..| .| | ..   ||  |||...  |.  .||. | |.. .  |.   |
khryptvPckPstavevivdGk.rvPihanwipts..GhphrfiatqgPlkntsedfwamlvqydvekivmlgqkvekleekceeylpvkisekldigrf

VVEFVSQTSddPYDRVILTTELTLIHR-LTNERRHVTHVQYLGWPDHGVPDVDrfLALIDQVESLRAAhprNMYTLVHCSAGIGRTGVVVQTMAMLAILR
 .. ... .    .  |   .| .       . | ||| ||  |.|.|||       | | .| .. .   .   .|||||||||.   . |  .   . 
kikiknkel..ilnkkiskrtlevedstgkfatrtvthyqysewtdrgvPksh..aelfdlmelvkks...ekPivvhcsaGiGrsvafigteylareve

RKRIPEAAAILRHLREQRARLVQTLQQY
 ..  | .  |.||||.| . ||| .| 
adptieltealkhlrehrwngvqtnsql
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 4361-4603 4.1e-24 80.0 In-house 26-254 (267) alignment 
Range on Protein: 4361-4603
Range on HMM: 26-254/267.0
SFSSSRRNSTKNRYTDILAYDDTRVKLRRgiTGSDYINANYVTFPNEEApfYFICAQGPTSQTVDDHWQLIWENDVRVIVMVAKLQEDGRSKcapYWPSS
| | .  |  .||. | | |||||| ||   .  .|||| ||   . .    ||  |.| ..|. |....| ...| |||.. |  .|   .   .||  
sqsiaeknqernrlddnlpyddtrvilrt..keeeyinasyvegyktkn..afivtqdplkntitdfltvihdqkvpvivlltkvftdnirl...fwPPk

DQGGLKTPSFVVEFVSQTSDDPYDrvILTTELtlihRLTNERRH-VTHVQYLGWPDHGvpDVDRFLALIDQVESLRAAHPRNMYTLVHCSAGIGRTGVVV
     |   ..||.  .  .. |.  |.| ||    .. ||  | ||   |  |      .   .|  .  . .       |   .|.||.|.||.|  .
mgqakkyqdltvehslekeendyq..iitlel....kfknesahnvtlyyykkwnint..nnkpylkplfgilaknqlengnrPlvvacsdGvGrsGtfl

QTMAMLAILRRKRIPEAAAILRHLREQRARLVQTLQQYEFCFTA
   ..|  ...  . .    ||..|.||  ||.|...| ..   
vidsqleraktegvsdifdflrkirsqriglvdtkeryiyihel
subfamily_egg_pd Subfamily egg 4363-4605 1e-23 78.5 In-house 35-267 (307) alignment 
Range on Protein: 4363-4605
Range on HMM: 35-267/307.0
SSSRRNSTKNRYTDILAYDDTRVKL--RRGITGSDYINANYVTfpNEEAPFYFICAQGPTSQTVDDHWQLIWENDVRVIVMVAKLQEDgrSKCAPYWPSS
. |  | .| |   .   | .||||  |||    |.| ||.|    .     ||.|| |   |||| |.......|. |||..  .|    .|  ||| .
aasdnnlekarskrvhckdssrvklelrrGqylddfihanrvk..Gkpllnefilaqaplkntvddfwrmvfqeevqyivmltsrkes..erceyywpka

DQGGLKT--PSFVVEFVSQtsDDPYDRVILTTELTLIHRLtNERRHVTHVQYlgwpdhgvpDVDRFLALIDQVESLRAAHPRNMYTLVHCSAGIGRTGVV
..  |.|   |. .| .    |.  | .   |.| |.    .| |.. | |.         ||.    .   .. || .      ..|..  |. .....
esdslvtvpGslrienlkv..dskadplfrvtklklvGgd.deerflehwqg.........dvnnssdvysplrvlrklrnlskpvvvqdilGvskaatl

VQT-MAMLAILRRkRIPEA--AAILRHLREQRARLVQTLQQYEFCFTAVL
|   .|.| .||   |           || .|   |..  .| | .  ||
vaieiallsllrG.pitkslvlravvflrlrrrlsvesvllylfvyrlvl
Kringle Kringle domain 375-448 1.5e-23 69.3 Pfam-A 4-76 (79) alignment 
Range on Protein: 375-448
Range on HMM: 4-76/79.0
DDGdnANYRGQINKTSSGKTCLPWSSSVAQA-NLVTPELYPNADLRHNYCRNPDGERTAWCFVEGTANAFEFCGV
..|   .|||....| ||..|. |.|..... .  |.| ...|.|..||||||||....||... ..  .|.| .
gnG..esYrGtvsttesgaeCqaWdselpkkhkkytaekkkaakLeenyCRNPdgdekpwCytkdpklrveyCsi
0048076 (Phosphotyrosine protein) phosphatases II 4488-4604 2e-22 74.8 In-house 30-139 (145) alignment 
Range on Protein: 4488-4604
Range on HMM: 30-139/145.0
LTTELTLIHRLTNERRHVTHVQYLGWPDHGVPDV-DRFLALIDQVESLRAAhprNMYTLVHCSAGIGRTGVVVQTMAMLAilrrKRiPEAAAILRHLREQ
.|| |.| . |... |......||.||||||||  . .|......|.....   .  .|||||||.||||..|  . ||     ..   .  .|...|.|
ittvlnltselellerlgiqylylpwpDhgvpdllellleflefieealke...ggpvlVHCsaGvgRtgtlvaaylmll....lg.vsleealelvrsq

RARLVQTLQQYEFCFTAV
|   |.. .|..|.. ..
rpgavpnpgqlrflyefe
subfamily_CG42327_pd Subfamily CG42327 4370-4528 1.7e-21 71.2 In-house 30-187 (319) alignment 
Range on Protein: 4370-4528
Range on HMM: 30-187/319.0
TKNRYTDILAYDDTRVKLRRGIT--GSDYINANYVTFPNeEAPFYFICAQGPTSQTVDDHWQLIWENDVRVIVMVAKLQEDGRSKCAPYWPSSDqGGLKT
 |.|. ...   .||| |.|      . |..|.||  .. .|| ..|.|| .  ..  | |...||.  |||| ...|.| |  .|| |.|... ..  |
dksrvinvvPlPetrvvlqrigdddkdeyldasyvrGyd.dapnsyiaaqvsledsssdfwrtvweqqsrvivqltdlselGikvcaeylPtke.tldnt

PSFVVEFVSQTSDDPYDRVILTTeLtLIHRL-TNERRHVTHVQYlGWPDHGVPDVDR-FLALI
 ..    |.    .  || ...| | |..|.  .| |..||  |  |.. .||  .. ..|..
slyGdilvtlkgrevkdryaist.l.llkrvdkeesrelthywy.kwleaevPaeeaaliaml
subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 4419-4603 2.4e-21 70.5 In-house 99-283 (302) alignment 
Range on Protein: 4419-4603
Range on HMM: 99-283/302.0
PTSQTVDDHWQLIWENDVRVIVMVAKLQEDGRSKCAPYWPSSDQGGLKTPSFVVEFVSQTSD-----DPYDRVILTTELTLIHRLTNERRHVTHVQYLGW
|  .|.. || || . .| ..| .... ||.  |||.|.    .| ||   . |. ||   |     |  . .. | |..  .. .. .. |  ... .|
pkkstlekhwalieqynvaivvqlcsfvedeekkcaeyysdkvggelkfgrytvktvsvktdleeftdkksfklytveiknekkkkkvkktvdilafsaw

PDHGVPD-VDRFLALIDQVESLRAAhprnmyTLVHCSAGIGRTGVVVQTMAMLAILRRKRIPEAAAILRHLREQRARLVQTLQQYEFCFTA
|||| |.  .  | ..   || . .       |||||||.|||| .|     . .  .|.. . . |.  .|. |   ||. ||  . .  
pdhGapkeaytaldilkfcesykkn......vlvhcsaGvGrtGtlvaikyGiqlcskkkvtdllsivlpvrqcryGavqdeqqliylllc
0048179 (Phosphotyrosine protein) phosphatases II 4495-4601 2.8e-20 67.9 In-house 33-138 (144) alignment 
Range on Protein: 4495-4601
Range on HMM: 33-138/144.0
IHRLTNE------RRHVTHVQYLGWPDHGVPDV-DRFLALIDQVESLRAahpRNMYTLVHCSAGIGRTGVVVQTMAMLailrRKRiPEAAAILRHLREQR
. .||.|       |.......|.||||||||  . .|.... .|....   ..  .|||||||.||||..|    |.    ...   .  .|...|..|
vinlteeyepefleregiqylhlpwpDhgvpdllellleflefieeale...eggpvlVHCsaGvgRtgtlvaaylmk....klg.lsleealalvrsrr

ARLVQTLQQYEFCF
   |.. .|..|. 
pgavpnpgqlrfLl
subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 4366-4606 1.5e-17 58.0 In-house 49-283 (302) alignment 
Range on Protein: 4366-4606
Range on HMM: 49-283/302.0
RRNSTKNRYTDILAYDDTRVKLRRgiTGSDYINANYVTFPNEEAPFYfiCAQGPTSQTV---DDHWQLIWENDVRVIVMVAKLQEDGRsKCAPYWPSSDQ
..|. ||. .|. ..|...|||    .  .|.||  |. |. . . .   || |.....   .. |...... .  .|.... .|  .     ..|   .
kknlkknqsedvpildsnlvklea..epdsyvnaskvevPeltrsii..laQlpkvdsedsveeFWrmvfqekivsvvilvgeeelkk.tlselfpkksg

GGLKTPSFVVE--FVSQTSDDPydrVILTTELtLIHRLTNER-RHVTHVQYlgWPDHGVPdvDRFLALIDQVESL-RAAHPRNMYTLVHCSAGIGRTGVV
  ..  .. |    |......      .. |. | .  .|     |.....  |... ||  ... .|| .....     . .  |..    |.|| |..
dykeygkmfvNnrkVekaeeek...tryviEv.lPegcsnsvlanvyvltn..Wkqkkvp..vkyaeliktaakvfakkikadentvivSknGaGRagaf

VQTMAMLAILRRKRIPEAAAILRHLREQRARLVQTLQQYEFCFTAVLA
.  .. .  | ..  |... |.. .|.||.| |..|.|| . . |.| 
ltlavaveklqkgkepnikeivksiRsqRpravdslkQyvslyialll
subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 4421-4606 4.2e-17 57.1 In-house 38-219 (255) alignment 
Range on Protein: 4421-4606
Range on HMM: 38-219/255.0
SQTVDDHWQLIWENDVRVIVMVAKLQEDGRSKCAPYWPSSDQGGLKTPSFVVEFVSqtsddPYDR-VILTTELTLIHRLTNERRHVTHVQYLGWPDHGVP
| |||  .| |  ..  |.||.. ..|.|. ||  |.|   .. ||     |         .    |. | |.|.      . . |.| .| ||...  |
sltvdkfyqtivqtktevvvmlcdfaeegvekcssyfplekdeklkladvnvtttk.....ssadvvlrtleitstlgekkkthtvkhysykGWieknaP

DVDRFLALIdqvesLRAAHPRnMYTLVHCSAGIGRTGVVVQTMA----MLAILRRKRIPE--AAAILRHLREQRARLVQTLQQYEFCFTAVLA
.  | .  |     |....      .||||.||||.   | .      |.  |..    |     .|..||..|.| ..|  |  |..  || 
elareilni.....lkvvrds.ksvvvhCstGiGrsaafvlaelvyqkmirsldttetveldylslleelrskrkraihtPlqlafsilmvld
subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 4413-4601 4.8e-17 56.8 In-house 6-196 (198) alignment 
Range on Protein: 4413-4601
Range on HMM: 6-196/198.0
FICAQGPTSQTVDDHWQLIWENDVRVIVMVAKLQEDGRSKCAPYWPSSDQGGLKTPSFVVEFVSQTSDDPYdrVILTTELTLIHRLTNERRHVTHVQYLG
.|..| |  .|. | ||..||     ||||   | .  .  . |||... |  |  |. |   . |.   |  .| .  ||         | ..| |.  
yiatqhplretladfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdy..titaliltnnttappstreishyqfts

WPDHGVPDVDRFLALIDQV--ESLRAAHPRNMYTLVHCSAGIGRTGVVVQTMAMLAIL--RRKRIPEAAAILRHLREQRARLVQTLQQYEFCF
| ..  |.|  |. ..      | .    ..   .|||| | | ||| |     .      .  . .   . . ||. |  .. .||.|.| .
wkekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiy
subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 4413-4601 4.9e-17 56.7 In-house 7-197 (199) alignment 
Range on Protein: 4413-4601
Range on HMM: 7-197/199.0
FICAQGPTSQTVDDHWQLIWENDVRVIVMVAKLQEDGRSKCAPYWPSSDQGGLKTPSFVVEFVSQTSDDPYdrVILTTELTLIHRLTNERRHVTHVQYLG
.|..| |  .|. | ||..||     ||||   | .  .  . |||... |  |  |. |   . |.   |  .| .  ||         | ..| |.  
yiatqhplretmadfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdy..titaliltnnttappstreishyqfts

WPDHGVPDVDRFLALIDQV--ESLRAAHPRNMYTLVHCSAGIGRTGVVVQTMAMLAIL--RRKRIPEAAAILRHLREQRARLVQTLQQYEFCF
| ..  |.|  |. ..      | .    ..   .|||| | | ||| |     .      .  . .   . . ||. |  .. .||.|.| .
wkekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiy
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 4364-4460 1.2e-15 51.7 In-house 44-156 (349) alignment 
Range on Protein: 4364-4460
Range on HMM: 44-156/349.0
SSRRNSTKNRYTDILAYDDTRVKLRRGITG----------------SDYINANYVTFPNEEAPFYFICAQGPTSQTVDDHWQLIWENDVRVIVMVAKLQE
.  .  .|||| ||| |. .||||....                   |||||||. ... .. . .|. | |   ||||....|  | |.... . . .|
eGvelfaknrykdilPyehsrvklkkslksskvikastsesdsgklddyinanylkltrisvekkyiatqaPlPstvddfykvillngvklvlsLnddke

DGRSKCAPYWPSS
 .  ||  ||   
lslekcdiywqel
CAP_GLY CAP-Gly domain 4233-4298 4.9e-15 41.6 Pfam-A 1-69 (69) alignment 
Range on Protein: 4233-4298
Range on HMM: 1-69/69.0
VGSRVYV--LGYGWGTLRYFGLHA-TKPGARCGVELDTANGLNNGTVDGYWYFAAAPRHGILCDPRKVK
||.|| |       ||.|| |    .|.|  .||||| ..| |.|.|.|  ||   |..|. ..| .|.
vgkrvevdpekerrGtvryvGpvptfksgiwvGveldeprGkndGsvgGvrYFeckpkrGvFvkperve
subfamily_hpo-7_pd Subfamily hpo-7 4422-4606 1.7e-14 48.3 In-house 45-225 (263) alignment 
Range on Protein: 4422-4606
Range on HMM: 45-225/263.0
QTVDDHWQLIWENDVRVIVMVAKLQEDGRSKCAPYWPSSDQGGLKTPSFVVEFVSQTSddpyDRVILTTELTLIHRLTNERRHVTHVQYLGWPDHGVPDV
||.|  .| |  .   |.||..  .|.|. ||  |.|    . .|     |      |    | .. | ||. .     . . |.| .| ||...  |  
qtidkfyqtivqtktevvvmLcDfneegvekcssyfPlekdekqklanvnvcttkvqs....dvllktlellstlgeKkkthtvkhysykgWiekndpel

-DRFLALIDQVESLraahpRNmyTLVHCSAGIGRTGVVVQTMA----MLAILRRKRIP--EAAAILRHLREQRARLVQTLQQYEFCFTAVLA
    | ... .  .     ..    ||||.||||.   . .      |.  |.       .   .|..||..|.| ..|  |  | .  || 
areilnilkvarns.....ks..lvvhcstGiGrsaafsvaElvyqkmirsldttstveldylsLleelrssrkraihtPmqLafsilmvLd
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 4501-4612 3e-14 47.2 In-house 87-198 (440) alignment 
Range on Protein: 4501-4612
Range on HMM: 87-198/440.0
ERRHVTHVQYLGWPDHGVPDVD-RFLALIDQVESLRaAHPRNMYTLVHCSAGIGRTGVVVQTMAMLAILRRKRIPEAAAILRHLREQRARLVQTLQQYEF
| | . . .| ||||.||| .    | .|..|.  .  .  |   ||||||| |||||..   ..|   .|    .  ...  .|..| ..||| .|| |
esrtlkqyhyqgwpdkgvpkfagpvlkmiqdvnesq.ekagngpllvhcsagagrtgviiavdsilreakrsdqidifsfinsmrnnrpqmvqtpeqyaf

CFTAVLAKLKAAD
 . |||  | ..|
vheavlegllcgd
PTEN_1 4505-4598 6.1e-14 47.3 In-house 92-183 (196) alignment 
Range on Protein: 4505-4598
Range on HMM: 92-183/196.0
VTHVQ--YLGWPDHGVPDVDRFLALIDQVESLRAAHPRNMYTLVHCSAGIGRTGVVVqtmamLAILRRKRIPEAAAILRHLREQR-ARLVQTLQQYE
  .|.   ....|||.|. ..... ...... . ..|..   |||| ||.||.|.||      | | .|.   |   |...||.| .. ... .| .
ksgveylhfpieDhgapslselfdicksfiewllsdpngnvVlVHCkaGlgRsGtvv.....aayLmykgkltadeAlelvrekRppgapnspsqer
subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 4366-4525 5e-11 36.7 In-house 94-242 (244) alignment 
Range on Protein: 4366-4525
Range on HMM: 94-242/244.0
RRNSTKNRYTDILAYDDTRVKLRRGITGSDYINANYVTFPNEEAPfyFICAQGPTSQTVDDHWQLIWENDVRVIVMVAKLQEDGRskcapYWPSSDQGGL
  || |||    | .|  || | .|  |  |||| .|      |   .| .| | ..|  | |... |  | |.|..  ..|.       ||| |.    
pnnswknregaglpfdfnrvplskgsmgntyinasfvgclgrtae..yiltqhpladtsmdfwkmmlerhvnvlvvlgsveeede.....ywpdseplew

KTPSFVVefvSQTSDDPYdRVILTTELTLIHRLTNERRHVTHVQYLGWPDHGVPDVDRFL
      |   . |  | . . | ...| .   . .  . .|  |   ||  |    | |.
yeeditv...tltdrdef.knikasnleiesdmneshqaltmfqisnwpsdgttpndhfi
0038934 (Phosphotyrosine protein) phosphatases II 4491-4600 1.8e-10 36.2 In-house 56-169 (194) alignment 
Range on Protein: 4491-4600
Range on HMM: 56-169/194.0
ELTLIHRLTNER---------RHVTHVQYLGWPDHG-VPDVDRFLALIDQVESLRAAHPRNmYTLVHCSAGIGRTGVVVqtmaMLAILRRKRIpEAAAIL
.|.|. .|||.          ..  ..  | .||.| ||. .  |  .| |.   ...| . . .||| ||.||||..|      ... | ..  | . .
klglvidltnteryYdpeefekagieylklpfpddgtvPsleillrfldlvdeflnedpgg.vvaVHCkaGlgRtGtlv....aaYLiyrlgm.saeeAi

RHLREQRARLVQTLQQYEFC
...|| |   ... ...|  
alfrekRpgaipnqdyleal
subfamily_eak_pd Subfamily eak 4365-4533 2.8e-10 34.1 In-house 47-209 (332) alignment 
Range on Protein: 4365-4533
Range on HMM: 47-209/332.0
SRRN--STKNrYTDILAYDDTRVKLRRGITGS-DYINANYVTFPNEEApfYFICAQGPTSQTVDDHWQLIWENDVRVIVMVAKLQEDGRSKCAPYWPSSD
..|     .|   .|. ||   |.|         ||||  . |..      .| .  .  . |   ||.. |.    ||....  | .  |   |.|   
tarleavnrn.vvkivpydrylvrltssqlnrlGyinaslaefsevGr..kyiltGiasedkvfafwqmvleqkspaivqlledvelkleksdkyfpdkt

QGGLKTPSFVVEFVSQtsddpYDRVILTTELtLIHRLTNERRHVTHVQYLGWPDHGVPDVDRFLALIDQVES
.  ||   . ||  .        | || | | |. .  ||  .| | .. || .  .| .. |||| . .  
reelkfGildverkef.....vkrniletrl.lelskGnethrvlhykvfGwtettlpkyedflalrkvmke
subfamily_PTPDC1_pd Subfamily PTPDC1 4504-4600 1.1e-09 33.0 In-house 82-168 (182) alignment 
Range on Protein: 4504-4600
Range on HMM: 82-168/182.0
HVTHVqYLGWPDHGVPDVDRFLALIDQVESlraAHPRNmYTLVHCSAGIGRTGVVVQTMAMLAilrrKRIPEAAAIlRHLREQRARLVQTLQQYEFC
....   .||.|.||. ..| | ..  |..   |  ..  . ||| || |||||.. .. . |    ||.  . || . .|..|.. .|| .| |..
giyvy.nfgwkDygvasleriLdivkvvaf...alqeg.kvavhChaGlGrtGvliacylvya....krltaekai.klvrskrpksiqtreqvelv
subfamily_CG42327_pd Subfamily CG42327 4545-4603 5.9e-09 30.0 In-house 251-310 (319) alignment 
Range on Protein: 4545-4603
Range on HMM: 251-310/319.0
LVHCSAGIGRTGVVVQT-MAMLAILRRKRIPEAAAILRHLREQRARLVQTLQQYEFCFTA
 |||| |.||||.|. . .|.  .   ||  .   .. ..|..||. |.| .|||| .  
vvhcsdGvGrtGlviasdiairsleeskrsvdiPqlvssvrrdrasavltkeqyefiykv
subfamily_Tensin_pd Subfamily Tensin 4506-4562 8.5e-09 28.2 In-house 70-125 (189) alignment 
Range on Protein: 4506-4562
Range on HMM: 70-125/189.0
THVQYLGWPDHGVPDVDRFLALIDQVESLRAAHPRNMyTLVHCSAGIGRTGVVVQTM
..|. .||||.  | .... ... ...|   |.|.|.   |||  | ||.||||.. 
kkvldfGWPdllaPsleklcsicksldsWlkadpqnv.vvvhckGgkgrigvvvsay
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 4505-4605 8.8e-09 29.5 In-house 217-341 (350) alignment 
Range on Protein: 4505-4605
Range on HMM: 217-341/350.0
VTHVQYLGWPDHGV-PDVDRFL-------ALIDQVESLRAA-HPRNMYTLVHCSAGIGRTGVVVQTMAMLA---IL---R-R-KRIPEA-------AAIL
| ..|.  |.| ..  .   .|        |||.  .       |    |||||||.||||..|    .|    ||   . . ...  |         |.
vyqlqvknWkDlslllnPesilqalevkndliddlfaeshldnarsspilvhCsaGvGrtGtlvtlDsllsdfeilenltkesrkldvaaktrDlisiiv

RHLREQRARLVQTLQQYEFCFTAVL
 .||.|| ..||.|.|. |.. |.|
nelrkqrismvqnldqfifiYeall
subfamily_CDKN3_pd Subfamily CDKN3 4510-4600 1.6e-07 25.1 In-house 104-188 (202) alignment 
Range on Protein: 4510-4600
Range on HMM: 104-188/202.0
YLGWPDHGVPDVDRFLALIdqvESLRAAHPRNMYTLVHCSAGIGRTGVVVQTMaMLAILRRKRIPEAAAILRHLREQRArlVQTLQQYEFC
.   .| .|||.   | ..   | || .      |||||  |.||. .|.  . .| .       .| . ||.|.  ||  .||..||.. 
hypiadglvpdiasclkil...eelrinlkayrktlvhcygglgrsslviacl.llylddtiepkdaidklrdlkgsra..iqtvkqynyl
subfamily_PTEN_pd Subfamily PTEN 4505-4591 1e-06 23.9 In-house 79-163 (184) alignment 
Range on Protein: 4505-4591
Range on HMM: 79-163/184.0
VTHVQYLGWPDHGVPDVDRFLALIDQVESLRAAHPRNMyTLVHCSAGIGRTGVVVQTMaMLAILRRKRIPEAAAILRHLREQRARLV
 ..|. ..  ||  | .. . ......|.  .. ..|.   ||| || |||||.. .  .| .|  ..  || ..  . | . .. |
dgrvavypfdDhnppplelleeivediekwleedkknv.vvvHCkaGkGRtGvlivay.llkslllekaeealelfaeaRtknkkgv
DSPc Dual specificity phosphatase, catalytic domain 4492-4598 2.4e-06 22.4 Pfam-A 19-131 (133) alignment 
Range on Protein: 4492-4598
Range on HMM: 19-131/133.0
LTLIHRLTN-----ERRHVTHVQYLGWPDHGVPDVDRFLALIDQVESLRAAHPRNMYTLVHCSAGIGRTGVVVqtMAMLAILRRKRIPEAAAILRHLRE-
.||.  .|.       .. .. .||. | .   . .    | . || ...|. ..   |||| ||| |.. ..  .| |   .. .. || ....  |. 
itlvinvtkevpnnnaikkseieylripvedetetkiskeleeavefiekaeqkgkkvlVHCqaGisRSatli..iaYlmktknlslneAyefvkerrsk

--QRARLVQTLQQYE
  ..|.....| .||
ispnagflrqLleye
DSPc Dual specificity phosphatase, catalytic domain 4492-4598 2.4e-06 22.4 In-house 19-131 (133) alignment 
Range on Protein: 4492-4598
Range on HMM: 19-131/133.0
LTLIHRLTN-----ERRHVTHVQYLGWPDHGVPDVDRFLALIDQVESLRAAHPRNMYTLVHCSAGIGRTGVVVqtMAMLAILRRKRIPEAAAILRHLRE-
.||.  .|.       .. .. .||. | .   . .    | . || ...|. ..   |||| ||| |.. ..  .| |   .. .. || ....  |. 
itlvinvtkevpnnnaikkseieylripvedetetkiskeleeavefiekaeqkgkkvlVHCqaGisRSatli..iaYlmktknlslneAyefvkerrsk

--QRARLVQTLQQYE
  ..|.....| .||
ispnagflrqLleye
subfamily_Sponge-PTP3_pd Subfamily Sponge-PTP3 4345-4403 5.4e-06 20.5 In-house 24-82 (95) alignment 
Range on Protein: 4345-4403
Range on HMM: 24-82/95.0
EAANTYDSIFRErQGG--SFSSSRRNSTKNRYTDILAYDDTRVKLRRgITGSDYINANYVT
|  | . ||     |   .  ||  |  |||. .|. || ||| |      |||||| .| 
efdnefksismt.sgapytvgsseanipknrflnifpydatrvvltt.krdsdyinacfvd
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 4527-4605 6.1e-06 19.8 In-house 250-341 (349) alignment 
Range on Protein: 4527-4605
Range on HMM: 250-341/349.0
LIDQVESLRAAHPRNMY-TLVHCSAGIGRTGVVVQTMAMLAILRRK-----RI-------PEAAAILRHLREQRARLVQTLQQYEFCFTAVL
|||.  .    .  ..   ||||||| |||||.|    .|.||        .|            |. .|| ||  .|| |.|. ... |.|
liddlfarlyldtdqlstllvhcsaGcGrtGvlvtldlllsileplqnesnkiklqallkDlisiivnelrkqrismvqnlaqfiaiyealL
DAP10 DAP10 membrane protein 4106-4148 6.8e-06 12.3 Pfam-A 24-66 (79) alignment 
Range on Protein: 4106-4148
Range on HMM: 24-66/79.0
STGSSGAAGMSLIVGPVVAVAVIVLLVVLVVVLRRRKRRQQTH
|    |.  . |. | | | ||. ||.| || .  | |.. . 
scsGcGplslpllaGlvaadavvsllivgvvfvcarlrsrpaq