Gene MbrePTP-sf4-2 in Monosiga brevicollis

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily MbrePTP-sf4
Protein sequence
ID Type Fasta BLAST phosphatome Note
MbreP051_AA protein Get Run
MbreP051_AA_2137-2434 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 2139-2435 6.9e-184 604.5 In-house 1-297 (297) alignment 
Range on Protein: 2139-2435
Range on HMM: 1-297/297.0
RAREDWHALEAEKDLLLDEARPENFSMAKRPGSLRSNRYRNILATNTNRVRLLGVPPERDYINADHIVFPDEPHDLKYIMAQGPLQATVNDFWTMVAQQG
|.|||...|||||||||||||.|.||.|||..|||.||||.||||...||.||.|..||||||||..|||||..|||||.|||||.|||.||||.||.|.
rlredrkeleaekdllldeargesfssakrnsslrknryrdilatddtrvkllrviterdyinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqd

VGTIAMVTQLQEGGRDKCYPYWPQVVGERQTAGDVIVEHLSSYSDEFNTVHITELQLYYRSQSRVVRHCQFLSWPDHGVPSDLEDLVRFQAQVCSCCIAV
|..|.||..|||.|||||.||||.||.||..||||.||.|||.||||..|..|||||.|||.||||||.|||||||||||||||||||||||||||||||
vrvivmvaklqedGrdkcapywpsvvqerlkagdvvveflsstsdefdrviltelqliyrsesrvvrhvqflswpdhGvpsdledlvrfqaqvcscciav

PMMLGVVEMFTAMVFLQLETFQAEMPRPAPLLVHCSAGVGRSGVVVLSDVIANKTRKGYIPDVRTMVSIVRSQRPMTIQTLEQFTLLYDFALKKVLE
||||..|||||||||||||...|||||.|.|||||||||||||||||||||..|.||..||||....||.|.||....||||||.||||..|||..|
pmmlalvemftamvflqleslraemprnayllvhcsaGvGrsGvvvlsdvilaklrkkripdvaailsilreqrarlvqtleqfellydavlkklke
0050432 (Phosphotyrosine protein) phosphatases II 2143-2431 9.1e-73 240.6 In-house 40-297 (308) alignment 
Range on Protein: 2143-2431
Range on HMM: 40-297/308.0
DWHALEAEKDLLLDEARPENFSMAKRPGSLRSNRYRNILATNTNRVRLlgvPPERDYINADHIVFPDEPHDLKYIMAQGPLQATVNDFWTMVAQQGVGTI
|.. ||.|   ||.   ....| |..|     |||..||.   .||.|   ... ||||| .. ...  .. |.|..||||. ||.||| || .|.| .|
dlglleeefeellsvkplleysvallpenkdkNrykdilpydhsRVkl...degsdYInAsyvdgyssklprkfIatqgPlpntvedFwrmvweqnvrvI

AMVTQLQEGGRDKCYPYWPQVVG-ERQTAGDVIVEHLSSYSDEFNTVHITELQLYYRSQSRVVRHCQFLSWPDHGVPSDLEDLVRFQAQVCscciavpmm
 |.|.|.| || ||..|||  .| . .. |.. |..|| ....  ||   ||. .  ..||.|.| ....|||||||...|.|..|  .|          
vmLtklvengrekcaqYwplelgggsleygkftvtllseevlddytvrtleltnlgdgesrtvthfhytnWpdhgvPpspeilldflelvr.........

lgvvemftamvflqleT-FqaempRPAPLLVHCSAGVGRSGVVVLSDVIANKTRKGYIPDVRTMVSIVRSQRPMTIQTLEQFTLLYDFALK
                . .     .. | .|||||||||.|.... |.. .  .|.. .||  .|  .|.|||. .||.||. .||. .|.
................ksl.....pggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtpeqylflyralle
0036941 (Phosphotyrosine protein) phosphatases II 2145-2434 6.2e-71 234.4 In-house 13-278 (297) alignment 
Range on Protein: 2145-2434
Range on HMM: 13-278/297.0
HALEAEKDLLLDEARPENFSMAKRPGSLRSNRYRNILATNTNRVRLlgVPPERDYINADHIVFPDEPHDlkYIMAQGPLQATVNDFWTMVAQQGVGTIAM
. |. | . ||.   . ..| |..|. |  |||..||. . .||.|   ... ||||| .. ..| ..   .|..||||. ||.||| || .|.| .| |
alllkefeellpllllgslsvallpenleknRykdilpydhtRVkl..ddegsdYinAsyvdgydlkrk..fIatqgPlpntvedFWrmvweqnvtvIvm

VTQLQEGGRDKCYPYWPQVVGERQTAGDVIVEHLSSYSDEFNTVHITELQLYY--RSQSRVVRHCQFLSWPDHGVPSDLEDLVRFQAQVCSCCIAVpmml
.|.| | || ||..|||  .|| .| ||..|. || ............|....   ..||.|.|.....|||||||.. ..|..|  .| ... .     
ltelvelgrekcaqywpleegesltygdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfielvrkvlkll....

gvvemftamvflqletfqaemPRPAPLLVHCSAGVGRSGVVVLSDVIANKTR---KGYIPDVRTMVSIVRSQRPMTIQTLEQFTLLYDFALKKVL
                     |.. | ||||||||||||.... |.. .  .   | . .|.  .|  .|.|||. .|||||.  ||.. |. ..
.....................psggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallellk
0051299 (Phosphotyrosine protein) phosphatases II 2141-2431 5.7e-69 228.1 In-house 19-284 (288) alignment 
Range on Protein: 2141-2431
Range on HMM: 19-284/288.0
REDWHALEAEKDLLLDEARPENFSMAKRPGSLRSNRYRNILATNTNRVRLLGVPP--ERDYINADHIVFPDEPHDlkYIMAQGPLQATVNDFWTMVAQQG
. ... |..| . ||.   . ..| |..|  |  |||..||. . .||.|  ...  . ||||| .| ... ..   .|..||||. ||.||| || .|.
angltglleefeellsllpdltlsaallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyidgynlkrk..fIatqgPlpntvedFWrmvweqn

VGTIAMVTQLQEGGRDKCYPYWPQvvGERQTAGDVIVEHLSSYSDEFNTVHITELQLY----YRSQSRVVRHCQFLSWPDHGVPSDLEDLVRFQAQVCSC
| .| |.|.|.| || ||..|||.  |. .| ||. |. || ....  ||.  |.. .    . ..|| |.| ....|||||||...|.|..|  .| ..
vrvIvmltklvelgrekcaqYwpl..ggsltygditvtllseevlddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpdspellldflrlvrka

CIavpmmlgvvemftamvflqletfqaemPRPAPLLVHCSAGVGRSGVVVLSDVIANKTRKGYIPDVRTMVSIVRSQRPMTIQTLEQFTLLYDFALK
.                            ... | .|||||||||.|.... |.. .  .|.. .||  .|  .|.|||. .||.||. ..|. .| 
la...........................sgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtpeqyrfvyealle
0040438 (Phosphotyrosine protein) phosphatases II 2142-2433 5.7e-69 228.1 In-house 15-276 (317) alignment 
Range on Protein: 2142-2433
Range on HMM: 15-276/317.0
EDWHALEAEKDLLLDEARPeNFSMAKRPGSLRSNRYRNILATNTNRVRLLGVPP--ERDYINADHIVFPDEPHDlkYIMAQGPLQATVNDFWTMVAQQGV
 |..||. |   ||.   . ..|.|..| .   |||..||    .||.|  ...  . |||||... .|....   .|..||||. ||.||| || .|||
sdftalleefedllslkld.tysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyvdgpnlkrk..fIatqgPlpntvedFwrmvweqgv

GTIAMVTQLQEGGRDKCYPYWPQvvGERQTAGDVIVEHLSSYSdeFNTVHITELQLY--YRSQSRVVRHCQFLSWPDHGVPSDLEDLVRFQAQVCSCCia
..| |.|.| | || ||..|||.  || .| ||..|..|| .    . .....|...  . |.|| |.| ....|||||||.....|..|  .| ...  
tvivmLteleelgrekcaqYwpl..getltygdftvtllseee..lagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfleavreal..

vpmmlgvvemftamvflqletfqaEmPRPAPLLVHCSAGVGRSGVVVLSDVIANKTRKGYIPDVRTMVSIVRSQRPMTIQTLEQFTLLYDFALKKV
                        | ... |.||||||||||.|.... ... .  .|.. .||   |  .|.|||. .||.||.  |||..|. .
........................e.dpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalleyl
0045450 (Phosphotyrosine protein) phosphatases II 2138-2431 2.9e-67 222.9 In-house 20-302 (307) alignment 
Range on Protein: 2138-2431
Range on HMM: 20-302/307.0
ARAREDWHALEAEKDLLLDEAR--PENFSMAKRPGSLRSNRYRNILATNTNRVRLLGVP---PERDYINADHIVF------PDEPHDLKYIMAQGPLQAT
 . ..... |..|   ||..    . ..|.|..| .   |||..||. . .||.|  ..   .. ||||| .. .      .   ...|.|..||||. |
lllldfltgllkefekllsvtvfllgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydlkrkfIatqgPlpet

VNDFWTMVAQQGVGTIAMVTQLQEGGRDKCYPYWPQVvGERQTAGDVIVEHLSSYSdeFNTVHITELQLY---YRSQSRVVRHCQFLSWPDHGVPSDLED
|.||| |. .|||..| |.|.| | || ||..|||.  || .| |.. |. || .    . .... | .    . ..|| |.| ....|||||||...|.
vedFwrmlweqgvtvivmltelvelgrekcaqywPde.geeltygnftvtllseeh..ldgytvrtlevtdldgtgesrtvthfhytgwpdhgvppsfee

LVRFQAQVCSCCIAvpmmlgvvemftamvflqletfqaeMPRPAPLLVHCSAGVGRSGVVVLSDVIANKTRKGYI---PDVRTMVSIVRSQRPMTIQTLE
|..|  .| ... .                          |.. | ||||||||||.|.... ...    .|. .   .|..  |. .|.|||  .|..|
lldfieevrkalee.........................lpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpe

QFTLLYDFALK
|.  ||...|.
qyrflyealle
0046845 (Phosphotyrosine protein) phosphatases II 2161-2433 3.5e-67 222.1 In-house 18-274 (284) alignment 
Range on Protein: 2161-2433
Range on HMM: 18-274/284.0
ENFSMAKRPGSLRSNRYRNILATNTNRVRLLGVPPE---RDYINADHIVFPDE---PHDLKYIMAQGPLQATVNDFWTMVAQQGVGTIAMVTQLQEGGRD
 ..| |..|  |  |||..||. . .||.|  ....    ||||| .. ..|     .  |.|..||||. ||.||| || .|.| .| |.|.| | || 
lslsvallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweqnvrvIVmltelvengre

KCYPYWPQVvGERQTAGDVIVEHLSSYSDEFNTVHITELQLYY-RSQSRVVRHCQFLSWPDHGVPSDLEDLVRFQAQVCSCCIAvpmmlgvvemftamvf
||..|||.  || .| ||..|. || . ..  ||.  ||. .   ..|| |.| ...||||||||...|||..|  .| ... .                
kcaqYwple.gevltygdftvtllseevkddytvrtleltnlgytgesrtvthfhytswpdhgvppspedlleflrlvrellen................

lqletfqaeMPRPAPLLVHCSAGVGRSGVVVLSDVIANKTRKGY---IPDVRTMVSIVRSQRPMTIQTLEQFTLLYDFALKKV
         .|.. | .|||||||||.|.... |.. .  .|.     .||  .|. .|.|||. .|||||. ..|...|  .
.........lpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyealleyl
0047943 (Phosphotyrosine protein) phosphatases II 2145-2430 4.1e-67 221.9 In-house 12-269 (273) alignment 
Range on Protein: 2145-2430
Range on HMM: 12-269/273.0
HALEAEKDLLLDEARPENFSMAKRPGSLRSNRYRNILATNTNRVRLlgVPPERDYINADHIVFPDEPHDlkYIMAQGPLQATVNDFWTMVAQQGVGTIAM
. |..| .|||.   . ..| |..|  .  |||..||. . .||.|   ... ||||| .. ... ..   .|..||||. ||.||| || .|.| .| |
tllleefelllslkplltysvallpenkdknrykdilpydhsrvkl..gdggsdyinAsyvdgynlkrk..fiatqgPlpntvedfwrmvweqnvrviVm

VTQLQEGGRDKCYPYWPQVVGE-RQTAGDVIVEHLSSYSDEFNTVHITELQLYYRSQSRVVRHCQFLSWPDHGVPSDLEDLVRFQAQVCSCCIavpmmlg
.|.|.| || ||..|||. .||  .| |...|..|| ....  ||.  ||. .  ..||.|.| ....|||||||..||.|..|  .| ...        
LtelvelgrekcaqYwpleggelsltygkftvtllseetkddytvrtleltnlgtgesrtvthfhytgwpdhgvppslesllefielvrkale.......

vvemftamvflqletfqaEMPRPAPLLVHCSAGVGRSGVVVLSDVIANKTRKGYIPDVRTMVSIVRSQRPMTIQTLEQFTLLYDFAL
                  . |.. | .|||||||||.|.... |.. .  .|.. .||   |  .|||||. .||.||. .||...|
..................alpsngpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrflyeall
0039614 (Phosphotyrosine protein) phosphatases II 2144-2433 1.9e-66 219.9 In-house 31-289 (297) alignment 
Range on Protein: 2144-2433
Range on HMM: 31-289/297.0
WHALEAEKDLLLDEARPenFSMAKRPGSLRSNRYRNILATNTNRVRLLGVPPE---RDYINADHIVFPDE-PHdlKYIMAQGPLQATVNDFWTMVAQQGV
 . |..|   ||.   .  .| |..| .   |||..||. . .||.| ...      ||||| .. ..|  ..  |.|..||||. ||.||| || .|||
ktllllefeellslkpd..ysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltr..kfIatqgPlpetvedFwrmvweqgv

GTIAMVTQLQEGGRdKCYPYWPQVVGerqTAGDVIVEHLSSYSdeFNTVHITELQLYYRSQSRVVRHCQFLSWPDHGVPSDLEDLVRFQAQVCSCCIAvp
 .| |.|.| | || ||..|||. .|   | ||. |. |. .    . .....| . . ..|| |.| |...|||||||..||.| .|  .| ... .  
tvivmLtklvelgr.kcaqywpeegg...tygdftvtllkveh..ldgytvrtlevtnngesrtvthfqytgwpdhgvppslellleflelvrealae..

mmlgvvemftamvFlqletfqaemPRPAPLLVHCSAGVGRSGVVVLSDVIANKTRKGYIPDVRTMVSIVRSQRPMTIQTLEQFTLLYDFALKKV
                        |.. | ||||||||||.|.... . . .  .|.. .||   |. .|.|||. .||..|.  |||..|. .
.............l..........pkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydallell
0043336 (Phosphotyrosine protein) phosphatases II 2142-2430 1.2e-65 217.1 In-house 17-274 (278) alignment 
Range on Protein: 2142-2430
Range on HMM: 17-274/278.0
EDWHALEAEKDLLLDEARpENFSMAKRPGSLRSNRYRNILATNTNRVRLLGVPPE--RDYINADHIVFPDEPHDlkYIMAQGPLQATVNDFWTMVAQQGV
 ....|..|   ||.    ...|.|..| .   |||..||. . .||.|  .. .   ||||| .. ... |..  .|..||||. ||.||| || ..||
nlktllllefeellsfkl.dtysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyvdgynvprk..fiatqgPlpetvedFwrmvwelgv

GTIAMVTQLQEGGRDKCYPYWPqvvGERQTAGDVIVEHLSSYSdeFNTVHITELQLY--YRSQSRVVRHCQFLSWPDHGVPSDLEDLVRFQAQVCSCCia
 || |.|.| | || ||..|||   |. .| ||. |. |. ..  ....... | .   . ..|| |.| ..|.|||||||..|..|..|  .| ...  
ttivmLtelvelgrvkcaqYwp...ggsltygdftvtllkeeh..lddytvrtlevtnlgdgesrtvthyhylgwpdhgvpeslsllldflkavreal..

vpmmlgvvemftamvflqletfqaEmPRPAPLLVHCSAGVGRSGVVVLSDVIANKTRKGYIPDVRTMVSIVRSQRPMTIQTLEQFTLLYDFAL
                        | ... |.||||||||||.|.... ... .  .|.. .|.   |. .|.|||. .||..|.  ||...|
........................e.dsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflyeall
DSPc_SM00195 2148-2431 6.1e-62 204.7 In-house 3-260 (263) alignment 
Range on Protein: 2148-2431
Range on HMM: 3-260/263.0
EAEKDLLLDEARPENFSMAKRPGSLRSNRYRNILATNTNRVRLLGVP--PERDYINADHIVFPdePHDLKYIMAQGPLQATVNDFWTMVAQQGVGTIAMV
..| . |.... |.... |... . . |||.|||  . .||.|   .  .. ||||| .| ..   .. |||..||||. ||.|||.|| ...| .|.|.
keefekleestspketteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikga..nkkkkyIatQgPlpstvedFWrmvweekvkiivml

TQLQEGGRDKCYPYWPQVVGERQTAGDVIVEHLSSYSDEfNTVHITELQLYYRS--QSRVVRHCQFLSWPDHGVPSDLEDLVRFQAQVCSCCIAVpmmlg
|. .| |. ||. |||.  |. .| |.. |.  .  ... . .....|.| .    ..| |.. |. .|||||||.. ......  .| ..         
teeeengkekcdrywpeesggketfgkisvklvevekkk.deiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkksksts.....

vvemftamvflqletfqaemprPAPLLVHCSAGVGRSGVVVLSDVIANKTRKGYIPDVRTMVSIVRSQRPMTIQTLEQFTLLYDFALK
                       .|..|||||||||.|..|. |.| .| ...  .|.  .|. .|.|||. .|||||.. .|. .|.
......................sgpivVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaile
PTPc_SM00194 2148-2431 6.1e-62 204.7 In-house 3-260 (263) alignment 
Range on Protein: 2148-2431
Range on HMM: 3-260/263.0
EAEKDLLLDEARPENFSMAKRPGSLRSNRYRNILATNTNRVRLLGVP--PERDYINADHIVFPdePHDLKYIMAQGPLQATVNDFWTMVAQQGVGTIAMV
..| . |.... |.... |... . . |||.|||  . .||.|   .  .. ||||| .| ..   .. |||..||||. ||.|||.|| ...| .|.|.
keefekleestspketteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikga..nkkkkyIatQgPlpstvedFWrmvweekvkiivml

TQLQEGGRDKCYPYWPQVVGERQTAGDVIVEHLSSYSDEfNTVHITELQLYYRS--QSRVVRHCQFLSWPDHGVPSDLEDLVRFQAQVCSCCIAVpmmlg
|. .| |. ||. |||.  |. .| |.. |.  .  ... . .....|.| .    ..| |.. |. .|||||||.. ......  .| ..         
teeeengkekcdrywpeesggketfgkisvklvevekkk.deiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkksksts.....

vvemftamvflqletfqaemprPAPLLVHCSAGVGRSGVVVLSDVIANKTRKGYIPDVRTMVSIVRSQRPMTIQTLEQFTLLYDFALK
                       .|..|||||||||.|..|. |.| .| ...  .|.  .|. .|.|||. .|||||.. .|. .|.
......................sgpivVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaile
0045098 (Phosphotyrosine protein) phosphatases II 2153-2433 1.3e-61 203.8 In-house 15-272 (278) alignment 
Range on Protein: 2153-2433
Range on HMM: 15-272/278.0
LLLDEARPENFSMAKRPGSLRSNRYRNILATNTNRVRllgvpperDYINADHIVFPdephDLKYIMAQGPLQATVNDFWTMVAQQGVGTIAMVTQLQEGG
 ||    |  .. | ..|.|  |||..||. . .||.        ||||| .| ..    . |.|..||||. ||.||| |. ..|. .| |.|.|.|.|
fllllgipseitpalylgnldknRykdilpydhsrVk........dYINAsyidgy....pkkfIatqgPlpstvadfwrmlwelgitvivmltelvelg

RDKCYPYWPQvvGERQTAGDVIVEHLSSYSDEFNTVHITELQLY----YRSQSRVVRHCQFLSWPDHGVPSDL--EDLVRFQAQVCSCCIAVPMMLGV-V
| ||..|||   |. .| ||. |. || .  .  |..  ...      .  .|| |.| ..|.||||||||.     . ..  ...... ..  .|.. .
rekcaqywpe..ggsltygdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllssl

emftamvflqletfqAEMPRPAPLLVHCSAGVGRSGVVVLSDVIANKTrkGYIPDVRTMVSIVRSQRPM-TIQTLEQFTLLYDFALKKV
                 .... | ||||||||||.|..|. . .      .   |.   |. .|||||.  .|.|||.  ||.|.|. .
...............llldsggpvlVHCsaGvgRtGtlvaaylmlell..eggvdlleavkelrsqRpglavqnleqyrflyefllell
0040439 (Phosphotyrosine protein) phosphatases II 2162-2431 2.2e-61 203.0 In-house 2-244 (249) alignment 
Range on Protein: 2162-2431
Range on HMM: 2-244/249.0
NFSMAKRPGSLRSNRYRNILATNTNRVRLLGVPP--ERDYINADHIVFPDEPHDlkYIMAQGPLQATVNDFWTMVAQQGVGTIAMVTQLQEGGRDKCYPY
..|.|..| ..  |||..||. . .||.|  .|     ||||| .| ... ...  .|..||||. ||.||| |. ..|...| |.|.|.| || ||..|
eysvallpenkdknrypdilpydhsrvklsilpglflsdyinAsyidgyyikrr..fiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqy

WPQvvGERQTAGDVIVEHLSSYSdeFNTVHITELQLY--YRSQSRVVRHCQFLSWPDHGVPSDLEDLVRFQAQVCscciavpmmlgvvemftamvflqle
||.  |. .. ||. |. || ..  .. .....|.|.  | ..|| |.| |...|||||||...|||..|  .|                          
wpl..ggsleygdftvtllsvev..kddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldfieavr.........................

TFQAEMPRPAPLLVHCSAGVGRSGVVVLSDVIANKTRKGYIPDVRTMVSIVRSQRPMTIQTLEQFTLLYDFALK
....| |.. |.||||||||||.|.... . . .  .| .  |.   |. .|||||. .|..||.  ||...|.
kaleelpkggpvlVHCsaGvgRtGtfiaaylmleqlekelgvdleeavkllrsqRpgavqnpeqyrflyealle
Y_phosphatase Protein-tyrosine phosphatase 2173-2430 2.7e-60 199.1 Pfam-A 3-234 (235) alignment 
Range on Protein: 2173-2430
Range on HMM: 3-234/235.0
RSNRYRNILATNTNRVRLLGVPPERDYINADHIVFPDEphDLKYIMAQGPLQATVNDFWTMVAQQGVGTIAMVTQLQEGGRDKCYPYWPQVVGERQTAGD
. |||..||. . .||.| | . . ||||| ..   .|  . |.|..||||. |..||| || |. | .|.|.|.|.| || || .|||.  .| .| ||
kknRykdilpydktrvklkgsegpsdYInAnyvkgyke..kkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeesltygd

VIVEHLSSYSDEFNTVHITELQLYYRSQS---RVVRHCQFLSWPDHGVPSDLEDLVRFQAQVCSCCiavpmmlgvvemftamvflqletfqaeMPRPAPL
. ||  .. ... . . ...|.|  . ..   | |.. .. .|||||||.. ..|...  .| .                              .. .|.
ikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkveksk...........................eaksgpv

LVHCSAGVGRSGVVVLSDVIANKTRKGYIPDVRTMVSIVRSQRPMTIQTLEQFTLLYDFAL
.|||||||||.|..|. |.. .. ...  .||  .|. .|.|||. .|.|||.  ||.  |
vVhCsaGvgRtgtfvaldilleqleaeeevdvlqivkelRkqRpgmvqsleqYiflykail
Y_phosphatase Protein-tyrosine phosphatase 2173-2430 2.7e-60 199.1 In-house 3-234 (235) alignment 
Range on Protein: 2173-2430
Range on HMM: 3-234/235.0
RSNRYRNILATNTNRVRLLGVPPERDYINADHIVFPDEphDLKYIMAQGPLQATVNDFWTMVAQQGVGTIAMVTQLQEGGRDKCYPYWPQVVGERQTAGD
. |||..||. . .||.| | . . ||||| ..   .|  . |.|..||||. |..||| || |. | .|.|.|.|.| || || .|||.  .| .| ||
kknRykdilpydktrvklkgsegpsdYInAnyvkgyke..kkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeesltygd

VIVEHLSSYSDEFNTVHITELQLYYRSQS---RVVRHCQFLSWPDHGVPSDLEDLVRFQAQVCSCCiavpmmlgvvemftamvflqletfqaeMPRPAPL
. ||  .. ... . . ...|.|  . ..   | |.. .. .|||||||.. ..|...  .| .                              .. .|.
ikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkveksk...........................eaksgpv

LVHCSAGVGRSGVVVLSDVIANKTRKGYIPDVRTMVSIVRSQRPMTIQTLEQFTLLYDFAL
.|||||||||.|..|. |.. .. ...  .||  .|. .|.|||. .|.|||.  ||.  |
vVhCsaGvgRtgtfvaldilleqleaeeevdvlqivkelRkqRpgmvqsleqYiflykail
subfamily_PTPRD_pd Subfamily PTPRD 2158-2433 8.4e-60 198.0 In-house 35-281 (564) alignment 
Range on Protein: 2158-2433
Range on HMM: 35-281/564.0
ARPENFSMAKRPGSLRSNRYRNILATNTNRVRLLGVP--PERDYINADHIVFPDepHDLKYIMAQGPLQATVNDFWTMVAQQGVGTIAMVTQLQEGGRDK
 . .... |. |   . ||| ||.| ...||.|  |.  .. ||||| .|   .  .. .|| .||||. |..||| || .| . || |.|.|.| |..|
gqqftweaankpaNkaKNRyanivaYdhsRVvLskvegdegsDYINAsfidgyr..krkayIAtqgPlaetiedFWRmvweqnsstiVmltkleEkgkvk

CYPYWPQVvGeRQTAGDVIVEHLSSYsdEFNTVHITELQL--YYRSQSRVVRHCQFLSWPDHGVPSDLEDLVRFQAQVCSCCiAvpmmlgvvemftamvf
|  |||.  | ..| |...|.  ...  |.....|....|    .|.|| ||. .| ||||||||   ..|...  .| ..                   
chkYWPek.g.tetygeltVtleeee..eladyeirtfklkkkkssesreVrqFhFtsWPdhgvpesatslLdlirkvraln.e................

lqletfqaemPRPAPLLVHCSAGVGRSGVVVLSDVIANKTRKGYIPDVRTMVSIVRSQRPMTIQTLEQFTLLYDFALKKV
          |   |..|||||||||.|. .  |.. .. ..    |....|. .|.||.. .|| ||.  ...  |. .
..........pdagPivVhCSaGVGRTGtfividamlerikeektvDiyqyvkalrkqRnamVqteeQYiFiheaileal
0042113 (Phosphotyrosine protein) phosphatases II 2164-2430 1.3e-59 196.9 In-house 2-240 (245) alignment 
Range on Protein: 2164-2430
Range on HMM: 2-240/245.0
SMAKRPGSLRSNRYRNILATNTNRVRLLGVPPE--RDYINADHIVFPDEPHDlkYIMAQGPLQATVNDFWTMVAQQGVGTIAMVTQLQEGGRDKCYPYWP
| |..| .   |||..||. . .||.|  ....   ||||| .. ... ..   .|..||||. ||.||| |. ..|. || |.|.. | || ||..|||
svallpenkdknrysdilpydhtrvklspdggdldsdyinasyvdgyritpk..fiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywp

QvvGERQTAGDVIVEHLSSYSdeFNTVHITELQLY--YRSQSRVVRHCQFLSWPDHGVPSDLEDLVRFqaqvcscciavpmmlgvvemftamvF------
.  || .| ||..|. || ..  ........|..   . ..|| |.| ..|.|||||||..||.|..|                         .      
l..gesltygdftvtllseeh..lddytvrtlevtnlgddesrevihyhylpwpdhgvpdllellldf.........................lefvrka

--LqletfqaemPRPAPLLVHCSAGVGRSGVVVLSDVIANKTRKGYIPDVRTMVSIVRSQRPMTIQTLEQFTLLYDFAL
            ... |.||||||||||.|.... . ...  .| .  ..   |  .|||||. .||..|.  ||...|
lae.........dsngpvlVHCsaGvgRtGtfiaaylmleqlekelgvsleeavkelrsqRpgavqtpsqyrflyeall
0037934 (Phosphotyrosine protein) phosphatases II 2163-2430 1.1e-56 187.5 In-house 2-239 (243) alignment 
Range on Protein: 2163-2430
Range on HMM: 2-239/243.0
FSMAKRPGSLRSNRYRNILATNTNRVRLlgvpPERDYINADHIVFPDephdlKYIMAQGPLQATVND----FWTMVAQQGVGTIAMVTQLQEGGRDKCYP
||.|..| .|  |||..||. . .||.|    .  |||||..|  ..     ..|  ||||. ||.|    || |. ..|...| |.|.|.| || ||..
fsiallpenlsknrysdilpydhsrvkl....egsdyinanliyvtp.....rliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaq

YWPqvvGERqTAGDVIVEHLSSYSdeFNTVHITELQLYY---RSQSRVVRHCQFLSWPDHGVPSDLEDLVRFQAQVCSCCIAVPMMLgvvemftamvflq
|||   ||  | ||..|. ||...  .. .....|.|..     ..| |.| ..|.|||||||.. |||..|  .|.... ..  .|             
ywp...gev.tygdftvtllseeh..lddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsll.............

letfqaEMPRPAPLLVHCSAGVGRSGVVVLSDVIANKTrkGyiPDVRTMVSIVRSQRPM-TIQTLEQFTLLYDFAL
        ..  |.||||||||||.|.... ...  .   |   |.   |  .|.|||.  .||..|.  ||...|
......aldsggpvlVHCsaGvgRtGtliaaylmllll..g..vdleeavkllreqRpgkavqtpsqyrflyeall
subfamily_PTPN3_pd Subfamily PTPN3 2162-2431 4.1e-55 181.7 In-house 32-273 (280) alignment 
Range on Protein: 2162-2431
Range on HMM: 32-273/280.0
NFSMAKRPGSLRSNRYRNILATNTNRVRLLGVPPerDYINADHIVFPDEP--HDLKYIMAQGPLQATVNDFWTMVAQQGVGTIAMVTQLQEGGRDKCYPY
. |.|..|  |  ||||.||. .. ||.|   .   |||||... .  .      .|| .||||. |..|||.|| .| . .| |.|.| | || ||. |
aisaarkpenlsknryrdilpydatrvklkeset..dyinanyvnmeipstglvnryiatqGPlaktatdfWqmvweqksslivmlttlverGrvkChqy

WPQvVGERQTAGDVIVEHLSSysDEFNTVHITELQLYYRS--QSRVVRHCQFLSWPDHGVPSDLEDLVRFQAQVCSCCiavpmmlgvvemftamvflqle
||.  ..... |.  |.  ..  || ... . || |  ..  ..| . . |.|.|||||||.| .|...|  .| ..                       
WPe.tedeleygefsvkceke..detksyvlrelvlkdketkeerkilqlqylaWpdhgvPddsadflefvervrklr......................

tfqaeMPRPAPLLVHCSAGVGRSGVVVLSDVIANKTRKGYIPDVRTMVSIVRSQRPMTIQTLEQFTLLYDFALK
       .  |..||||||.||.||..| ..   .. .     .  .|. .| || | .|| .|.... .  ||
.....sgkeePvvvhCsaGigrtGvlilletalalieaaepvypldivrtmrdqramlvqtasqykfvCeailk
subfamily_PTPN14_pd Subfamily PTPN14 2162-2430 2.3e-52 172.9 In-house 40-293 (300) alignment 
Range on Protein: 2162-2430
Range on HMM: 40-293/300.0
NFSMAKRPGSLRSNRYRNILATNTNRVRLLGVPP-ERDYINADHIVFPDEPHDLKYIMAQGPLQATVNDFWTMVAQQGVGTIAMVTQLQEGGRDKCYPYW
..| || |   . ||....|  . |||.|      . .|||| .|  .   ....||.|||||. ||.||| || .|||  |.|.|. .|.|..|.. |.
llstaklpenaeknrfkdvlPyednrvelsptkenstgyinassikvsvggkersyivaqgPleltvqdfWqmvWeqgvqlivmlteeeedgkeksfkyf

PQVVGERQTAGDVIVEHLSSYSDEFNTVHITELQLYY--RSQSRVVRHCQFLSWPDHGVPSDLEDLVRFQAQVCSCCIAVPMMLgvvemftamvflqlET
|.   ...|.     .  . .|.. ..|  | |.|..   .. | | | |.  |||||||.|... . .  .| | . ..  .               |.
PkleskkktvefgkfkvttkfsedsdsvittglklkhlpskeertvwhlqytDWpdhgvPeDvkgflsyLeevqsvrrktnsev..............es

fQAEMPrpaPLLVHCSAGVGRSGVVVLSDVIANKTRKGYIPDVRTMVSIVRSQRPMTIQTLEQFTLLYDFAL
 . . |   |.||||||||||.||..|||.. .   ..   |........| || . .||| |.. .|.  .
.keskP...PvlvhCsaGvGrtGvlilsdlliatlehneeidikkvlarLreqrmllvqtlaqYkfvYkvli
subfamily_PTPN6_pd Subfamily PTPN6 2165-2428 5.8e-50 165.0 In-house 48-292 (306) alignment 
Range on Protein: 2165-2428
Range on HMM: 48-292/306.0
MAKRPGSLRSNRYRNILATNTNRVRLL-GVPPERDYINADHIVFPDEPHDLKYIMAQGPLQATVNDFWTMVAQQGVGTIAMVTQLQEGGRDKCYPYWPQV
 ...|   . |||.|||  . .|| |     |. |||||. |    . .| .|| .|| |..||.||| || |.    | |.|.  | |..||..|||..
egakpenkeknryknilPfDhtrvilkepsvpgsdyinanyikkevkgsdksyiatqgclettvsdFWrmvwqensrvivmttkevErgkekCarYWPde

VGERQtAGDVIVEHLSSysDEFNTVHITELQL---YYRSQSRVVRHCQFLSWPDHGVPSDLEDLVRFQAQVCSCCIAVPmmlgvvemftamvflqletfQ
  ...  |.. |...|.  .. ..  . ||..      ...| |.. .| ||||||||.| . .. |  .| .    .                     .
eekee.yGkisvtnvse..ksladYilRelsvskkkkkkeerevfqyhfksWPdhgvpkdpgavLdfledvnrkqeele....................e

AempRPAPLLVHCSAGVGRSGVVVLSDVIANKTRKG---YIPDVRTMVSIVRSQRPMTIQTLEQFTLLYDF
|   .. |..||||||.|| | ... |.. .. .|    .  |....| .||.||   .|| .|. ..|  
a...eagpivvhCsaGiGRtGtfiviDillkliekkgldadidiqklvksvreqrsglvqteqqykfvyka
subfamily_PTPN9_pd Subfamily PTPN9 2160-2428 7.8e-50 164.6 In-house 31-285 (297) alignment 
Range on Protein: 2160-2428
Range on HMM: 31-285/297.0
PENFSMAKRPGSLRSNRYRNILATNTNRVRLLGVPP--ERDYINADHIVFPDEphDLKYIMAQGPLQATVNDFWTMVAQQGVGTIAMVTQLQEGGRDKCY
  .| ..| .. |. ||| ..|  .  || |  |.   . |||||...    .     .| .||||. ||.||| || .| | .| |.|.. | || || 
eGtflasklranleknrytdvlcydetrvvlakvdedeasdyinanfvdGykq..kkafiatqGplkktvsdfWrmvWeqevlvivmttrvvergrlkcg

PYWPQVVGERQTAGDVIVEHLSSYSDEFNTVHITELQLYYRSQSRVVRHCQFLSWPDHGVPSDLEDLVRFQAQVCSCCIAVpmmlgvVEMFTamvflqle
 |||.  ....  ||. |....  . |  .|.. |..    ..|| | | |||||||.||||. ..|. .  .| .   ..      |. ..        
qyWpleeessaefgdlsvsnveveeeedykvrvleiknvkteesrkvthfqflsWPdyGvPssaaslldvlekvrekqala......vkelg........

TFQAEMPRPAPLLVHCSAGVGRSGVVVLSDVIANKTRKGYIPDVRTMVSIVRSQRPMTIQTLEQFTLLYDF
  ..  |.  |..||||||.||.|  .  |.  .. ..    ||.  |. .|.||  .||| ||... |  
dewkghpsgPPivvhcsaGiGrtGtfitldiclsrleevgtvdvvetvkllrtqrafsiqtpeqyefcyla
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 2164-2428 9.9e-49 160.7 In-house 13-259 (270) alignment 
Range on Protein: 2164-2428
Range on HMM: 13-259/270.0
SMAKRPGSLRSNRYRNILATNTNRVRL--LGVPPERDYINADHIVFPDEPHDlKYIMAQGPLQATVNDFWTMVAQQGVGTIAMVTQLQEGGRDKCYPYWP
.. .     . |||..|| . . ||||  |   ..  |||| ..   |. .  ||| |.|||..|...|| |. .. | .|.|.|.|.| ||.||  |||
dlpeaargkklnRyadiLPsPatRvrleeleedsataYinAnyvrGfdgekk.kYiaamgPlpttlksfwrmiweekvtaivmttgleEkgrkkCerYWp

QVVGERQTAGDVIVEHLSSYSDEFNTVHITELQLYYRSQSRVVRHCQFLSWPDHGVPSDLEDLVRFQaqvcscciavpmmlGVVEMFTAMvflqlETFQA
. ..|. .  |  .. |.. .   .   .|.|.| .....| . | .. .|||||||.. .. .. .               ...|. |.       .. 
aepkekvkledgkikvlalseekeegyiltrlrleekgeerrlvHfwyntWpdhgvpreedsslstd..............qllkmlrav.....rrsek

EMPRPAPLLVHCSAGVGRSGVVVLSDVIANKTRKGYIPDVRTMVSIVRSQRPMTIQTLEQFTLLYDF
|. .  ||||||||||||.|.... | . .   .    || .... .| .|.  .|. ||...||  
eldkaePllvHcsaGvgRtGtlialDiavrlLeetkkvdvlaiieelRkdRmalvqhpeqyeflyka
subfamily_PTPN23_pd Subfamily PTPN23 2136-2435 9.3e-48 157.5 In-house 13-282 (288) alignment 
Range on Protein: 2136-2435
Range on HMM: 13-282/288.0
DRARAREDWHALEAEKDlllDEARPENFSMAKRpgSLRSNRYRNILATNTNRVRLLgvPPERDYINADHI--VFPDEPhdlKYIMAQGPLQATVNDFWTM
...   . .. || ..|    |||    ..||.      ||.|.||  . ||| |     . ||||| ..  . |  |   ..|..|.||| |.|||| |
gktaldkkfkeleqkqd...kearkrsiaiakl..yseknrsrdilPyDhnRvklr..gskDDYinAsfvkdlspgcP...dfiatqaPlqstlnDFWlm

VAQQGVGTIAMVTQLQEGGRDKCYPYWPQVVGERQTAGDVIVEHLSSYSDEFNTVHITELQLYYRSQSRVVRHCQFLSWPDHGVPSDLEDLVRFQAQVCS
| .| . .| |... .| |. |.  |||.  || .. ||. |   |  . |    .. .|.    .. . |.| |. |||..|||.  |.|..|  .| |
vyeqkssviVmllskeelgkpkvdrYwPedkgetvkfgdlsvtlksvretethvervlkletldadavksvshlqltsWpelGvPasPetllqfldeves

CCIAVPMMLGVvemftamvflqletfqaemprpaPLLVHCSAGVGRSGVVVLS-DVIANKTRKGYIPDVRTMVSIVRSQRPMTIQTLEQFTLLYDFALKK
.  ||   . .                       ||.|||||||||.||. |   .... ...  ..|.  .|| .| ||   .|. ||.  .|.  |..
ayeavqrkskt.......................PlvvhCsaGvgRtgvfalvyaavrelekgnglldiiqvvsrlreqRrfmvqekeqlkfsyeavlea

VLE
. .
arr
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 2160-2427 4.4e-47 155.4 In-house 15-262 (274) alignment 
Range on Protein: 2160-2427
Range on HMM: 15-262/274.0
PENFSMAKR--PGSLRSNRYRNILATNTNRVRLLGVPPE---RDYINADHIVFPDEPHDlKYIMAQGPLQATVNDFWTMVAQQGVGTIAMVTQLQEGGRD
| ||....   .|| . |||..||  .. || |    .|    .||||..|  .|| .   |. .||||. ||.||| |. |. |  | |.|.|.|  ..
PlnfdqeeldvfgsqtknryktilPnensrvllesessededssyinanyikGydeesk.ayvatqGPlpntvadfWrmiyqeevqvivmltklkeaneq

KCYPYWPQVVGE--RQTAGDVIVEHLSsySDEFNTVHITELQLYYRSQSRVVRHCQFLSWPDHGVPSDLEDLVRFQAQVcscciavpmmlgvvemftamv
||  |.|.  .    .. ||| ..  .    | |  ....| | | ...| | |  . .|||| .| | . |... ..|                     
kCavyfPdaedyeiserygdveikvek..iverndysvrklvlkylerersvkhywytdWPdhksPddantlldlvlev.....................

flqLETFQAEMPRPAPLLVHCSAGVGRSGVVVLSDVIANKTRKGYIPDVRTMVSIVRSQRPMTIQTLEQFTLLYD
    |. ..|  . || .||||||.|| |. .  ..  .. |.  . ||  .|. .| .|   .|| ||. |.. 
...eesreeenaklapvvvhCsaGiGrtGcfiaisiavrqlreeivvdvlkivcnlrldrGGmvqtseqyelihr
subfamily_Ptp69D_pd Subfamily Ptp69D 2138-2427 1.9e-41 137.1 In-house 15-280 (307) alignment 
Range on Protein: 2138-2427
Range on HMM: 15-280/307.0
ARAREDWHALEAEKDLLLDEARPENFSMAKRPGSLRSNRYRNILATNTNRVRLLGVPP--ERDYINADHIVFPDEPHdlKYIMAQGPLQATVNDFWTMVA
.| |.  . |. | . |  .  . . .....   .  ||| .| | . .||.|  ..   . |||||..|   .| .  |.|.||.|..||..||| |.|
srkrdtdfglakeyekLeareidkstkvsekkenalknRyedikafDktRvkLkkingkedsdYinasfikgykekk..kfiaaqdPveatigDfWRmia

QQGVGTIAMVTQLQEGGRDKCYPYWPQVvgERQTAGDVIVEHLSSYSD------EFNTVHITELQLYyRSQSRVVRHCQFLSWPDHGVPSDLEDLVRFQA
.| | .| |...|.|  |.||  |||.   . .  ||..|.  |. .       |..  .. |       .|| |   ....|.|  ||   . |...  
eqevtlivmlsnlteknrkkcakYWpie..devqygdilvklvseekhsdyiiReldvskkkeesge.vedsrkvvqyhytgWkDskvPevargllklie

QVCSCCIAVpmmlgvvemftamvflqletfqaemprPAPLLVHCSAGVGRSGVVVLSDVIANKTRKGYIPDVRTMVSIVRSQRPMTIQTLEQFTLLYD
|| .                                 .|..|||||||||||..|  |.. .....    |.  .|  .||||.. .| |||.. || 
qvrelykln...........................rsPivvhCsaGvgrsgifvaldsllqqlkaedkvdifetvkdLrsqRnllvqsleqYvflyr
subfamily_PTPRG_pd Subfamily PTPRG 2162-2434 3.7e-41 136.0 In-house 38-288 (563) alignment 
Range on Protein: 2162-2434
Range on HMM: 38-288/563.0
NFSMAKRPGSLRSNRYRNILATNTNRVRLLGVPP---ERDYINADHIVFPDEPHdlKYIMAQGPLQATVNDFWTMVAQQGVGTIAMVTQLQEGGRDKCYP
. .....| . | ||| ||.| .  ||.| ..|    . |||||..|      .  ..|..||||. |..||| |. .| | .| |.|.|.| || ||  
daehsqkpenkrKnRylnivaydrsRvklsplpgkkkklDYinAnyidGyqksk..afiatqgplkdtfddFWrmiWeqnvaiivmitnlvergrrkcdv

YWPQvvGERQTAGDVIVEH-----LSSYSDEfnTVHITELQLYYRSQ---SRVVRHCQFLSWPDHGVPSD-LEDLVRFQAQvcscciavpmmlgvvemft
|||.   | .| | . |       |..|. .  |. | .|.|   .|    ..||. .. .|||||||.  | .|   . .                   
YWPk..desetygalqvtlieeevlalytvr..tlviknlklkkkkqcdteklvrqyhytkWPdhgvPehslpvLifvkks...................

amvflqletFQAEMPRPAPLLVHCSAGVGRSGVVVLSDVIANKTRKGYIPDVRTMVSIVRSQRPMTIQTLEQFTLLYDFALKKVL
          .|..    |..|||||||||.|. .  | . .. ..  . .|  ..  .|.||.. .|| ||.. |.|  |. ..
.........saankaeaGPivvHcsaGvgrtGtyivldtllkqiqqenavnvfgflkhiraqRnflvqteEqYiflhdalleaia
subfamily_PTPRK_pd Subfamily PTPRK 2157-2434 7.2e-41 135.0 In-house 29-278 (314) alignment 
Range on Protein: 2157-2434
Range on HMM: 29-278/314.0
EARPENFSMAKRPGSLRSNRYRNILATNTNRVRLLGVPPE--RDYINADHIvfpDE-PHDLKYIMAQGPLQATVNDFWTMVAQQGVGTIAMVTQLQEGGR
|. .| .  ||.    . ||. .||| .  ||.|  .  .   |||||. |   |   .  ..|..||||| ||.||| .| ...  .| |.|.|.| ||
eslfegwdaakkdenreknrsgdilaydrsrvflitidgdpssdyinaali...dsykrpaafivtqgPlqetvkdfWrlvydencasivmltelvevgr

DKCYPYWPQvvgERQTAGDVIVEHLSSYSDEFNTVHITELQLYYRS--QSRVVRHCQFLSWPDHGVPSDLEDLVRFQAQVCSCCIAvpmmlgvvemftam
 ||. |||.   . .. ||. || ...  ..   | |  ..   |.  . |.||. |||.||||.||   . |... ..| .                  
vkClkyWPe...dtevygdikvelvetellaelvvrifrveklargqeeirevrqfqflgWpdhdvPvsatgllklvrrvkksqee..............

vflqletfqaempRPAPLLVHCSAGVGRSGVVVLSDVIANKTRKGYIPDVRTMVSIVRSQRPMTIQTLEQFTLLYDFALKKVL
             .  ...|||||| ||.|. .  |.. .  ..  . ||  .|  .||...  ..| ||....|| .|  .|
.............eaGrivvhCsaGaGrtGtfiaidivldmieregvvdvfnavktlrsrkvnmveteeqykfiydvileacl
subfamily_PTPRA_pd Subfamily PTPRA 2161-2430 7.2e-41 135.1 In-house 48-292 (330) alignment 
Range on Protein: 2161-2430
Range on HMM: 48-292/330.0
ENFSMAKRPGSLRSNRYRNILATNTNRVRLLGV--PPERDYINADHIVFPDEphDLKYIMAQGPLQATVNDFWTMVAQQGVGTIAMVTQLQEGGRDKCYP
  . .|..    . ||. |||  . .|| |  .   .| ||||| .|    |    |.| ||||.. ||.||| |. .|   || |.|.|.|  ..||. 
atlelaskeenkeknrvvnilPydfsrvilsvkeGveesdyinasfidGyke..kdkfiaaqGPkeetvedfwrmiweqksativmltelkerkeekcaq

YWPQVvGeRQTAGDVIVEHLSSYSDEF---NTVHITEL-QLYYRSQSRVVRHCQFLSWPDHGVPSDLEDLVRFQAQVCSCciavpmmlgvvemftamvfl
|||.  |   | |.. ||   .   .      . ...| .   . .||.||   | |||| |||..   .... ..| ..                    
ywPde.G.lvtyGnirvevedetvlvdytvrkflvqqlpdatrekksrlvrqfhftswPdvGvPfepiGmlkllkkvkkl....................

qletfQAEMPRpaPLLVHCSAGVGRSGVVVLSDVIANKTRKGYIPDVRTMVSIVRSQRPMTIQTLEQFTLLYDFAL
     .  .    |. |||||||||.|  .  | . .. .   . ||  .|. .| |||  .||.||....|   |
.....nqqsag..pivvhcsaGvGrtGtfivldavlervkaerkvdvfefvkrlrlqrpqmvqtdeqyefiykvll
subfamily_PTPRB_pd Subfamily PTPRB 2160-2332 7.3e-41 135.1 In-house 40-209 (293) alignment 
Range on Protein: 2160-2332
Range on HMM: 40-209/293.0
PENFSMAKRPGSLRSNRYRNILATNTNRVRL--LGVPPERDYINADHIvfPDEPHDLKYIMAQGPLQATVNDFWTMVAQQGVGTIAMVTQLQEGGRDKCY
 .. ..|...     |||.|||. ...||.|  |   .. |||||..|  |.     ..| .||||  ||.||| || .. . .| |.||| |.|. || 
dqavkaaelavnraknrytnilpydhsrvkLaalkdesgsDYinanyi..pgynsprefiatqGPlpetvddfWrmvwekkssiivmltqlvekgkvkCe

PYWPQVVgERQTAGDVIVEHLSSysDEFNTVHITELQLYYRSQSRVVRHCQFLSWPDHGVPSDLEDLVRFQAQVC
 |||.   | .. ||. |. ...  .| .   | ||..  ....| ||...|.||||||||.. . |..|  .| 
eYWPade.epvlyGdikvtlvae..eeledwvirelkiekekeerkvrqyhftsWpdhgvPektktlldfvrtvr
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 2172-2434 2.2e-40 133.3 In-house 34-267 (283) alignment 
Range on Protein: 2172-2434
Range on HMM: 34-267/283.0
LRSNRYRNILATNTNRVRLLGVPPerDYINADHIV-FPDEPHDLKYIMAQGPLQATVNDFWTMVAQQGVGTIAMVTQLQEGGRDKCYPYWPQVVGERQta
 | ||...|.... .||.|   ..  ||||| .|.   .. .| |||.||.||. || ||| || .. . .| |.|.|||. | ||  |||.   |    
krknrnqeivpadqwrvelksesr..dyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfdekitaivmltklqedlrikCsqyWPkrGsedy..

GDVIVEHLSSYSDefNTVHITELQLYYR--SQS-RVVRHCQFLSWpdhgvpsdledlvrfqaqvcscciavpMMLGVVEMFTAM-VFLQLETFQAEMPRp
|.  |     ..   |.  | || | .   ..|  .. | |.  |                           .  |   .  ..  | .. . | | .. 
Geftvtlrketts..nsfiikelllrvnssakstlllahyqvidW...........................leygeqaiinslvkfnkvislqteskk.

APLLVHCSAGVGRSGVVVLSDVIANKTRKGYIPDVRTMVSIVRSQRPMTIQTLEQFTLLYDFALKKVL
.|..||||.|.||..| .   .  .. .   . ||  .| |.| ||.| .|||.|. |... .|.. |
gPivvhCstgiGrtavfiaasasvkdaltesvvdvfavvkimreqrmmavqtldqyklvhelvleqal
subfamily_PTPN13_pd Subfamily PTPN13 2162-2334 9e-38 125.1 In-house 28-198 (273) alignment 
Range on Protein: 2162-2334
Range on HMM: 28-198/273.0
NFSMAKRPGSLRSNRYRNILATNTNRVRLLGVPPerdYINADHIVFPDEPHDLKYIMAQGPLQATVNDFWTMVAQQGVGTIAMVTQLQEGGRDKCYPYWP
. ...|.    . |||||.|  .  ||.| .  .   ||||..|  | . .  .||..||||  ||.||| || .| .  |||||. .|.|. ||  |||
tcevgkkkenkdknryrnvlPydetrvklgdegg...yinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweqkaeviamvtlekekgkvkchrywP

QVVGERQTAGD-VIVEHLSSY-SDEFNTVHITeLQLYYRSQSRVVRHCQFLSWPDHGVPSDLEDLVRFQAQVCSC
.  ... .. . . || |     |.|.  ... ..    ..|| | | .| .||||||||  ..|..| |.| . 
esknkklkvsnrlevellkvqkldgfvvrala.vkdsesgesrevahlnfvkwPdhgvPssaaellqfvaevrrl
0041856 (Phosphotyrosine protein) phosphatases II 2173-2434 8.5e-37 121.9 In-house 3-172 (182) alignment 
Range on Protein: 2173-2434
Range on HMM: 3-172/182.0
RSNRYRNILATNTNRvrllgvppERDYINADHIVFPDEPHDlkYIMAQGPLQATVNDFWTMVAQQGVGTIAMVTqlqeggrdkCYPYWPQVVgerqtagd
  |||..||  . .|          |||||  ....  . .  .|..||||. ||.||..|. ..|..|| ..|         ...|||. .        
dknrysdilpydhsr........dldyInanlylgslpatr..fiatqgpllstvadflrmlkelgittivnlt.........eelywpell........

vivehlssysdefntvhitelqlyyrsqSRVVRHCQFLSWPDHGVPSdLEDLVRFQAQVCScciavpmmlgvvemftamvflqletfqaempRPAPLLVH
                             | . . ..|.|||||||. |..|..|  .| .                               .. | |||
............................erlgiqylylpwpDhgvpd.ldelldfieevle...............................eggpvlVH

CSAGVGRSGVVVLSDVIANKtrkGyiPDVRTMVSIVRSQRPMTIQTLEQFTLLYDFALKKVL
|||||||.|..|. ...  .   |   ...  |. |||.||. ..|..|. .|....| ..|
CsaGvgRtgtlvaaylmkkl...g..vsleeavklvrsrRpgmvitpnqyfflqlallelll
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 2164-2334 8.6e-37 121.8 In-house 33-202 (281) alignment 
Range on Protein: 2164-2334
Range on HMM: 33-202/281.0
SM-AKRPGSLRSNRYRNILATNTNRVRL--LGVPPERDYINADHIvfPDEPHDLKYIMAQGPLQATVNDFWTMVAQQGVGTIAMVTQLQEGGRDKCYPYW
.  .|..     |||.|| | .  ||..       . |||||...  |    . .|| .|||. |....|| || .| | .|.|||.  |.|. ||. ||
ataskadenvlknrYsnivaYDatrvkvtpneenkntDYinanfv..pgykgekeyiatqgPvPaslvafWqmvweqkvsaivmvtreieagklkChrYW

PQVVgERQTAGDVIVEHLSSYSDEFNTVHITELqLYYRSQSRVVRHCQFLSWPDHGVPSDLEDLVRFQAQVCSC
|.   .. . |||.|..... . .    .  .|     ...| |.. ....|||||||.. ..|. |...| ..
Pddn.selkygdvtvkstaeeekatyierkfkl.eresgetreveqlaytaWPdhGvPattkellefrkevlkl
0051429 (Phosphotyrosine protein) phosphatases II 2198-2433 2.3e-36 121.2 In-house 5-225 (272) alignment 
Range on Protein: 2198-2433
Range on HMM: 5-225/272.0
DYINADHIVFPdephdL------KYIMAQGPLQATVNDFWTMvAQQGVGTIAMVTQLQEGGRDKCYPYWP----------QVVGERQTAGDVIVEHLSSY
.|||| ..  .            ... ..|||..|..|||.. ...|. || ..... | ||.||..|||            . .. . |.. | .|| .
gyiNardvggy.....grvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllsee

SDEFNTVHITELQLY-YRSQSRVVRHCQFLSWPDHGVPSDLedLVRFQAQVcscciavpmmlgvvemftamvflqletfqAEmprPAPLLVHCSAGVGRS
  .. ..   .| |. . ...| |.| ....|||||||..   |... ...                             ..   . |.|||||||..|.
llldyilrellltlllsagearevmhlhytdwpdhgvpqea..llellell.............................ld...ggpvlvHCsaGkdRT

GVVVLSDVIANKTRKGYIPD--------VRTMVSIVRSQRPMTIQTLEQFTLLYDFALKKV
|.||. . ..    .  | |        ..  |. .|.|||  .|| ||.  ||...|. .
GtvvallllllgvsletivddYlltnlyleeaveelraqrpgavqteeqylflyeallell
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 2158-2331 6e-36 119.0 In-house 34-204 (288) alignment 
Range on Protein: 2158-2331
Range on HMM: 34-204/288.0
ARPENFSMAKRPGSLRSNRYRNILATNTNRVRLLG--VPPERDYINADHIvfPDEPHDLKYIMAQGPLQATVNDFWTMVAQQGVGTIAMVTQLQEGGRDK
 . .. ......   . |||||||. . .||.| .    .. ||||| .|   .| .. ||| .||||..|||||| .| .. . ||.|.|.| |||. |
ektksvtagrlavnakknRyrnilpyDekrvklkkleeeagaDYinasyi..dgekkkkkyiatqgPladtvndfWelvyenktstivmltelveggktk

CYPYWPQVvGERQTAGDVIVEHLSSYSDEfNTVhITELQLYYRSQSRVVRHCQFLSWPDHGVPSDLEDLVRFQAQV
|  |||.  .. .  |.| |. ..|   | ..|   .| |  . . . . . |.|.||||||| . ..|. .  ||
CeeYWPda.dkpknyGsvtvtlveskele.dfv.lrklllekkkteleitqyqylaWpdhgvPeskapllellrqv
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 2159-2331 3.6e-35 116.7 In-house 44-214 (298) alignment 
Range on Protein: 2159-2331
Range on HMM: 44-214/298.0
RPENFSMAKRPGSLRSNRYRNILATNTNRVRLLG--VPPERDYINADHIVFPDEPHdlKYIMAQGPLQATVNDFWTMVAQQGVGTIAMVTQLQEGGRDKC
. |. ..|..|   . ||| .|.| .  ||.|       | ||||| ..   .. .   .|..|.||..||.||| || .. .||| |.|.|.| .. |.
eeeekevarkpenkkkNRyadiialdssRvvLekedadeesdYiNAsflhaykgrn..afiatqaPltetvedFWrmvteedigtiVmltnleeldktky

YPYWPQVVgeRQTAGDVIVEHLSSysDEFNTVHITELQL--YYRSQSRVVRHCQFLSWPDHGVPSDLEDLVRFQAQV
  |||..    .| |.. |. ||.  .||  . ...|..  . ....| ||. .| ||||.|||.  . .. . ..|
hkywPdeg..ketygeitvsllsk..eefadlivrklkvskkkeekerevrqlhftsWpdkgvpenatsvldllrkv
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 2172-2331 1.8e-34 113.7 In-house 44-201 (515) alignment 
Range on Protein: 2172-2331
Range on HMM: 44-201/515.0
LRSNRYRNILATNTNRVRL--LGVPPERDYINADHIvfPDEPHDLKYIMAQGPLQATVNDFWTMVAQQGVGTIAMVTQLQEGGRDKCYPYWPQVVGERQT
 . |||.|||  ...||.|  .   |. ||.|| .|  |    |  || .|||..|.|.||| .| |. | ||||||.|.|| . ||  |||.. |.   
fkknryknilPydsvrvklevindnPhsdyfnasyi..psfdndkayiasqgPnkasvddfWrlvlqenvttiamvtklkegdkikcgkyWPdkpgdsvk

AGDVIVEHLSSYSDEFNTvhITELQLYYRSQSRVVRHCQFLSWPDHGVPSDLEDLVRFQAQV
 | . || .|  ..   .  . .|..   ..|| |   .|  |||.||| .   |...  .|
fGsikvelvsleactggi..krkltvlkgddsrtvtqfhfteWPdkGvpkhtssllklikev
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 2162-2331 4e-34 112.9 In-house 35-202 (315) alignment 
Range on Protein: 2162-2331
Range on HMM: 35-202/315.0
NFSMAKRPGSLRSNRYRNILATNTNRVRL--LGVPPERDYINADHIvfPDEPHDLKYIMAQGPLQATVNDFWTMVAQQGVGTIAMVTQLQEGGRDKCYPY
.   |. .   . |||.|||  ...||.|  .   |..||||| .|  .   .|  || .||||.|.|.||| || |. | ||.|||..||| . ||  |
rqrvaretinfkknryknilPldsarvkleviddsPdsdyinasyi..ksvdddkayiasqgPlkasvddfwrmvlqekvttivmvtkkqegdkikcrqy

WPQVVGERQTAGDVIVEHLSSYSDEFNTvhITELQLYYRSQSRVVRHCQFLSWPDHGVPSDLEDLVRFQAQV
||.  ..    | . || ||  .|   .  . .| .    .|| |   ||  |||.||. ..  |...  .|
wPdrkadsvefGsikvellsleadtdgv..arklvtrkseesrtvtqfqftewPdkGvdkqtssllklikev
subfamily_PTPN12_pd Subfamily PTPN12 2164-2328 4.4e-33 109.4 In-house 33-196 (290) alignment 
Range on Protein: 2164-2328
Range on HMM: 33-196/290.0
SMAKRPGSLRSNRYRNILATNTNRVRLLGVPPER--DYINADHIVFPDEphDLKYIMAQGPLQATVNDFWTMVAQQGVGTIAMVTQLQEGGRDKCYPYWP
......   . |||..||  ...|| |     |   |||||..|  ...  .|.|| ||||| .|..||| |. .. |  . |. .. | |. ||  |||
eagekeenvkknrykDilPydksrvelskieeeegsdYinanfikgveg..kleyiaaqgPLpktlddfWrmiweknveivvmaCrevelgkkkCerYWp

QVVGERQTAGDVIVEHLSSYSDEfNTVHITELQLYYRSQSRVVRHCQFLSWPDHGVPSDLEDLVRFQ
. ..|. . |.. |.  .    . .   |  |..  ...||.|.  .. .||||||||  ..|... 
eegeeelefgefevtleeekavd.ddflirtLkveaqkesrkvyqfhYtaWPDhgvPssakslleli
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 2167-2331 4.8e-33 109.5 In-house 42-204 (318) alignment 
Range on Protein: 2167-2331
Range on HMM: 42-204/318.0
KRPGSLRSNRYRNILATNTNRVRLLGV--PPERDYINADHIvfPDEPHDLKYIMAQGPLQATVNDFWTMVAQQGVGTIAMVTQLQEGGRDKCYPYWPQVv
  |   . ||| |||| .. ||.|  .   .. |||||..|  .   .. .|| ||.||  |..||| || .|.  .| |.||..| |..|.  |||.  
lepvnkaknryanilaydhtrvkLqmlegeegsDyinanyi..dGyrrkkayiaaqaPlpetieDfWrmvWeqnsavivmltqeeergkakvhryWPsk.

gERQTAGDVIVEHLSSYSDEFNTVHITELQLYYRSQSRVVRHCQFLSWPDHGVPSDLEDLVRFQAQV
 . .. |.. ||  .. . .  ..   ...    ..||.||  .. ||||.|||..  .|. .  ||
.gsrsygklvvelkeevelsdyvlrefkvtrteeeesrqvrqyhytsWpdegvpesgaslldlvrqv
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 2164-2431 9.5e-33 108.4 In-house 42-277 (315) alignment 
Range on Protein: 2164-2431
Range on HMM: 42-277/315.0
SMAKRPGSLRSNRYRNILATNTNRVRL--LGVPPERDYINADHIVFPDEPHdlKYIMAQGPLQATVNDFWTMVAQQGVGTIAMVTQLQEGGRDKCYPYWP
 .||.    . ||| ||.|..  ||.|  | . |. ||.||. |   . ..  .|| ||||. |.|.||| .| .. .|.| |.|.| || . |.  |||
dvakkienkqknryiniiaydksrvqlpllendphsdyvnanfidGynkkr..ryiaaqgpnvasvkdfwrlvfeedigkivmltnlvegekrkaekywp

QVvgeRQTAGDVIVEHLSSYSDEFNTvhITELQLYYRSQSRVVRHCQFLSWPDHGVPSDLEDLVRFQAQVcscciavpmmlgvVEMFTAMVflqletfqa
     . . | . | . |    .  |  .  |   .... | |   .. |||| |||     |. .  .|                 |. |         
dk...kviyGkitvtrkseevnteyt..vrtlsvvfgdnirevvqlhytswpdmgvpkytiplmnlirtv.............kqhhtnsv.........

emprpAPLLVHCSAGVGRSGVVVLSDVIANKTRKGYIPDVRTMVSIVRSQRPMTIQTLEQFTLLYDFALK
     ....|||||||||.|  .  | . ..     . ||  ..  ||..|   .|..||. ..||  |.
.....gaivvhcsaGvGrtGtfitldavldqaeaenaidvynfitgvrqnrikmvqvaeqyqfiydalle
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 2154-2427 9.9e-33 108.6 In-house 31-282 (325) alignment 
Range on Protein: 2154-2427
Range on HMM: 31-282/325.0
LLDEARPENFSMAKRPGSLRSNRYRNILATNTNRVRL--LGVPPERDYINADHIVfpDEPHDLKYIMAQGPLQATVNDFWTMVAQQGvGTIAMVTQLQEG
||    .  . .| .|     ||..|..| . .|| |  ..  |. |||||...   |.     .. || || ||.||.| .| .    .. .|.   ..
llpsddgiakkvamkpenkaknrfknvvaldksrvvletkkddpssdyinasylr..ddkkkdvflaaqaPltatindlWrlvldWr.csvvvvlneldl

GRDKCYPYWPQVVGERQTAGDVIVEHLS--SYSDEFntVHITELQLYYRSQSRVVRHCQFLSWPDHGVPSDLEDLVRFQAQVCScciavpmmlgVVemft
| |.|  |||. .|. .| | . |.  .   .||      . ...   . ..| |.  |. ||.| ||.     |. .   |            |     
gkdrcavywpkemgksktfGglevklrtieeisdyv..hrvldvkqvkkGetrsvkqfqlqswddmGvqkrpatlisilqlvka..........vs....

amvflqlETFQAEMPRPAPLLVHCSAGVGRSGVVVLSDVIANKTRKGYIPDVRTMVSIVRSQRPMTIQTLEQFTLLYD
       |. .|.    .|.||||||||||.|| .    ...|  .    |.  .|  .| .||  ..| .|..|.|.
.......ervtantkastpilvhcsaGvGrtGvfislysalakvieesrvdifgfvkklrkdrpsmvetvdqyiliye
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 2164-2331 1.2e-32 108.1 In-house 2-166 (250) alignment 
Range on Protein: 2164-2331
Range on HMM: 2-166/250.0
SMAKRPGSLRSNRYRNILATNTNRVRLLGVP--PERDYINADHIVFPDEPhdLKYIMAQGPLQATVNDFWTMVAQQGVGTIAMVTQLQEGGRDkCYPYWP
|.||.|  .  ||| .|.| .  || |  .    | ||||| ..   ||     .|..|||||||..||| || .. .||| |.|.|.| ..  .  |||
svakkpqnkeknryadiialdssrvvLekekgdkesdyinasflhgyder..kafiatqgPlqatiedfWrmvleeksgtivmLtnLkesekt.yhqywP

qvVGERQTAGDVIVEHLSSysDEFNTVHITELQLY--YRSQSRVVRHCQFLSWPDHGVPSDLEDLVRFQAQV
  | . .. ||| |. ||.  .||  . ...|.|    ....|.||. .|..||| |||   .  . .. .|
..vekaekyGdvtvsllsk..eefadytkrklklskakkaderivrqlhfvvWPdkgvPevatavLellkkv
0036282 (Phosphotyrosine protein) phosphatases II 2198-2428 1.2e-32 108.4 In-house 3-165 (174) alignment 
Range on Protein: 2198-2428
Range on HMM: 3-165/174.0
DYINADHIVFPDEPHdlKYIMAQGPLQatvndFWTMVAQQGVGTIAMVTQLQEGGRDKCYPYWPQvvgerqtagdvivehlssysdefntvhitelqlYY
||||| .. .   .   ..|  ||||.     || |. ..|. |. |.....| |. ||. |||                                  ..
dyinaspldlsyitp..rliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe.................................lr

RSQSRVVRHCQFLSWPDHGVPSDLEdLVRFQAQVCSCCiavpmmlgvvemftamvflqletfqAEmPRPAPLLVHCSAGVGRSGVVVLSDVIANKTRkGY
 . .| . . ..| |||||||.. . | .|  .| ...                         .| ..  |.||||||||||.|..|. . .    .   
edlerlgiqylylpwpDhgvpdlsi.llefvkfveeal.........................se.dpggpvlVHCsaGvgRtGtlvaaylmlrgll.es

IPDVRTMVSIVRSQRPMTIQTLEQFTLLYDF
  |.  .|  .|.|||. .|| .|.  ||.|
lvdaldlvrelRlqrpgmvqtpsQyrflyyf
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 2145-2331 1.6e-32 107.9 In-house 22-207 (305) alignment 
Range on Protein: 2145-2331
Range on HMM: 22-207/305.0
HALEAEKDLLLDEarPENFSMAKRPGSLRSNRYRNILATNTNRVRLLGVPPE--RDYINADHIVFPDepHDLKYIMAQGPLQATVNDFWTMVAQQGVGTI
..|||. ..| .|  .| . . |.  . ..||...|   ...|..|   . .  .||||| ..   .  .  |||.|||||. ||.||| .. .  | ||
kgleaqykslyee..eesidvgkkeankaknrlkeitlldddriiltekeslddsdyinasyvdgyk..rkkkyivaqgPlkntvadfWrliveekvsti

AMVTQLQEGGRDKCYPYWPQVVGERQTAGDVIVEHLSSysDEFNTVHITELQLYY---RSQSRVVRHCQFLSWPDHGVPSDLEDLVRFQAQV
 |.|.|.|||.|||. |||. ..|..  |...||  |.   ...   . .|..      ..||.| . |. .|||||||     |...  .|
vmltklveggkdkCrqYWpesktekkefgefsvelkse..ktasdyieRklkisiededkesrtvlqyqltdWPdhGvpqfatsllslikrv
0043147 (Phosphotyrosine protein) phosphatases II 2196-2429 1.7e-32 107.9 In-house 4-157 (172) alignment 
Range on Protein: 2196-2429
Range on HMM: 4-157/172.0
ERDYINADHIVFPDEPHDlkYIMAQGPLQATVNDFWTMVAQQGVGTIAMVTQLqeggrdkcypywpqvvgerqtagdvivehlssysdefntvhitelQL
 .||||| .. ..  |..  .|. ||||. |..||| |. ..|...| ..|.|                                             ..
gsdyinasyldlyyipdr..fiatqgplrntladfwrmlkelgithivnltel.............................................ly

YYRSQSRVVRHCQFLSWPDHGVPsDLEDLVRFQAQVCSCCIAVPmmlgvvemftamvflqletfqaemprPAPLLVHCSAGVGRSGVVVLSDVIAnktrK
..   .| . . ..|.||||||| .|| | .|  .. . ..  |                            | ||||||||||.|..|. . .     .
dpellerlgiqylylpwpDhgvp.llellleflefidellalsp..........................ggpvlVHCsaGvgRtgtlvaaylml....l

GYipDVRTMVSIVRSQRPMTIQTLEQFTLLYDFA
|.  ..   |. ||..||. .|. .|  .||.|.
gl..sleeavalvrekRpgavqnpsqyrflyyfe
0046846 (Phosphotyrosine protein) phosphatases II 2187-2430 1.8e-32 107.9 In-house 2-170 (176) alignment 
Range on Protein: 2187-2430
Range on HMM: 2-170/176.0
RVRLLGVPPERDYINADHIVFPdephdlKYIMAQGPLQATVNDFWTMVAQQGVGTIAMVTQLQEGGRDKCYPYWPQVVGERQtagdvivehlssysdefn
|.|||| ..  |||||. |. .      ..|  ||||  |. ||. |. ..|.... ..|...| || ||. |||.. ..                    
rlrllgldldldyinanlilgs......rpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgi..................

tvhitelqlyyrsqsrvvrHCQFLSWPDHGVPSDlEDLVRFQAQVCSCCiavpmmlgvvemftamvflqletfqaemPRPAPLLVHCSAGVGRSGVVVLS
                   . ..| |||||||.. |.| .. ... ..                              .  | |||||||.||.|..|. 
...................qylhlpwpDhgvpdl.elllellefireal............................keggpvlVHCsaGigRtgtlvaa

DVIANktrkGYIPDVRTMVSIVRSQRP-MTIQTLEQFTLLYDFAL
. .      ..  .|   .. ||.||| . .|| ||   ||.|.|
yllel....ekglsveealalvreqRplgavqtpeQyrflyefel
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 2157-2427 1.1e-31 104.7 In-house 24-271 (287) alignment 
Range on Protein: 2157-2427
Range on HMM: 24-271/287.0
EARPENFSMAKRPGSLRSNRYRNILATNTNRVRLLGVPPE-RDYINADHIvfPDEPHDLKYIMAQGPLQATVNDFWTMVAQQGVGTIAMVTQLQEGGRDK
|. .  |  |.   . . ||| ..|  . .|| |   .    |||||...  .   .| ..| ||||. |||.|||..| .. . .....|.  | .| |
esstatfkaaeelaavkknryadvlPiddtrvllsaegelGsdyinanyv..asytddeafiaaqgPiaatvrdfwravletrsasvitmtreveearlk

CYPYWPQVVGERQTAGDVIVE-HLSSYSDEFNTVHITELQLyYRSQSRVVRHCQFLSWPDHGVPSDLEDLVRFQAQVCScciavpmmlgVVEMftamvfl
|| |||.     .  |  .|    .  . |. .  .  ..|    ..|||.  ..|||||....     |.||  .|             .|.       
cykywPerevPmrvGGysvvlldydikePeygvralrlidl.etrearvvkqldllswPdkvlaPtavglirfvldvkq..........hiel.......

qletfQAEMPRPAPLLVHCSAGVGRSGVVVLSDVIANKTRKGYIPDVRTMVSIVRSQRPMTIQTLEQFTLLYD
     . .     ||.||...|.||||...   |. ..  .    || ..|  .| .|   .|.  |. |||.
.....ardasevGPlvvhddvGiGrsGillatlvlvsrledlGrvdvaavvirlreyraalvqavvqlrllye
0049260 (Phosphotyrosine protein) phosphatases II 2214-2428 4e-30 99.9 In-house 9-145 (152) alignment 
Range on Protein: 2214-2428
Range on HMM: 9-145/152.0
LKYIMAQGPLQATVNDFWTMVAQQGVGTIAMVTQLQEGGRDKCYPYWpqvvgerqtagdvivehlssysdefntvhitelqlyyrsqsrvvrHCQFLSWP
 ..| .|||.  |..||| |. ..|..|| |.|.|.| |..||. |.                                             . ..| ||
fefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi.............................................qylhlpwp

DHGVPSDLEDLVRFQAQVCSCCIAVPMmlgvvemftamvflqletfqaemprpaPLLVHCSAGVGRSGVVVLSDVIAnktrkgYIPDVRTMVSIVRSQRP
|||||.. . |  .   .  ...                               | ||||||||||.|..|. . .       .  ..   |. ||..||
Dhgvpdlsqlllflllfieklaldkgg...........................pvlVHCsaGvgRtgtlvaaylml......lgvsleeavalvrekRp

MTIQTLEQFTLLYDF
. ... .|  .||.|
gavpnpgqlrflyef
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 2154-2331 5.9e-30 99.4 In-house 31-207 (319) alignment 
Range on Protein: 2154-2331
Range on HMM: 31-207/319.0
LLDEARPENFSMAKRPGSLRSNRYRNILATNTNRVRLLGVP--PERDYINADHIVFPDepHDLKYIMAQGPLQATVNDFWTMVAQQGVGTIAMVTQLQEG
||.|| ...|. |...   . |||.|||| .  || |  ..  .. |||||..|   .  .  |.| .|.||. |..||| || .... .. |.|.|.| 
llkeavndtfdsaskeenkkknryqnilaydrtrvvlseldgvegsdyinasfidgyq..erekfiatqaPlentiedfWrmvWeeessivvmltklvek

GRDKCYPYWPQVvgERQTAGDVIVEHLSsySDEFNTVHITELQLYYRSQ---SRVVRHCQFLSWPDHGVPSDLEDLVRFQAQV
.. |.  |||.   . .. | .||. ..   .| . . | .|.|  .|.   .| | | |...||||.|| ..  |. .  ..
lkvklkkywpee..nfeeyGrlivtlee..eeeledyiirklklnkkssevetRevkhfqyteWpdhdvPekatslldllkri
subfamily_PTPN1_pd Subfamily PTPN1 2157-2333 4.7e-29 96.0 In-house 18-193 (290) alignment 
Range on Protein: 2157-2333
Range on HMM: 18-193/290.0
EARPENFSMAKRPGSLRSNRYRNILATNTNRVRLLGvpPERDYINADHIVFPDepHDLKYIMAQGPLQATVNDFWTMVAQQGVGTIAMVTQLQEGGRDKC
||.  . . ||.|     ||||..   .  |..|     . |||||. . ...   . .||..||||  ||. || || .|   .. |. .. | .. ||
easdfptreaklpenrnlnryrdvspydhsrikler..adndyinaslvelee..akrsyiltqGPlpntvdhfWqmvWeqkskavvmlnkvvekeqikc

YPYWPQVVGERQTA---GDVIVEHLSSYSDEFNTVHITELQLYYRSQSRVVRHCQFLSWPDHGVPSDLEDLVRFQAQVCS
. ||||   |..       . |. .|  . .. ||.. ||.     ..|.. |  ...||| |||.    ...|  .| .
aqywPqgeeekellledtklkvkliseerksyytvrllelenlktqetreilhfhyttwpdfgvpespaaflkflfkvre
subfamily_PTPRN_pd Subfamily PTPRN 2136-2334 1.1e-27 91.5 In-house 27-219 (297) alignment 
Range on Protein: 2136-2334
Range on HMM: 27-219/297.0
DRARAREDWHALEAEkdllldEARPENFSMAKRPGSLRSNRYRNILATNTNRVRLLGV--PPERDYINADHIVfPDEPHDLKYIMAQGPLQATVNDFWTM
.. | ...|.|| |       || |.  ..||..  .. ||....|. . .||.|       . |||||  |.  ..|    || .|||| .|| ||| |
nkdrlekewealcay......eaepstkevakaeknvkknrskavlpydhsrvklkeeasaeksdyinasail.dhdprapayiatqgplastvadfwqm

VAQQGVGTIAMVTQLQEGGRDKCYPYWPQVVGERQTAGDVI--VEHLssYSDEFnTVHITELQLYYRSQSRVVRHCQFLSWPDHGVPSDLEDLVRFQAQV
| .|||  | ..|.|.| |  .|. |||.   |   . .|    ||.  ..|..  |    |.    |..| |    |||||..|||.    |. |. .|
vweqGvvvivnltrleeegvkqckrywpdeGsevyhiyevhlvsehi..wcddy.lvrsfylknlqtsetrtvtqfhflswpeegvPasaksllefrrkv

CSC
  .
nks
0049772 (Phosphotyrosine protein) phosphatases II 2166-2432 1.4e-27 92.7 In-house 41-279 (314) alignment 
Range on Protein: 2166-2432
Range on HMM: 41-279/314.0
AKRPGSLRSNRYRNILATNtNRVRLlGVPPE--RDYINADHIVFPdephdLKYIMAQGPLQATVNDF----------WTMV--AQQGVGTIAM-------
|. .     ||| .||  . |||.| .  |    |||||...  .     ||.| .||||. ||.||          |.||   .. | .| |       
adlflnrdknryldilpad.nrvil.pglpvsgsdyinasyvdgf.....lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivmsrdevla

--------------VTQLQEGGrdkcypywpqvvgerqtagdvivehlssysDEFNTVHITELQlyyrsqS----------RVVRHCQFlSWPDHGVPsD
               ..| ..|                              .| .  .. .|.      .          ........  .||...| .
delsrLdaAlgKtpllildgng..............................neptaadlellk......eelydpelferlgikylri.pvpDgsap.l

LEDLVRFQAQVCSCciAvpmmlgvvemftamvflqletfqaempRPAPLLVHCSAGVGRSGV-VVLSDVIANKtrkGYipDVRTMVSIVRSQRP-----M
|||. .| . . ..                              .. |.||||.||.||.|. ||.  ..      |.  .... .. ||..||      
ledfdeflefieea..d...........................kggpvlvHCkaGkgRtgtfvvaaylmkll...gv..sleealedvrlkRpinpnpg

TIQTLEQFTLLYDFALKK
.|..|||.   ... |..
fieqleqyefilealley
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 2174-2333 2.4e-27 90.7 In-house 6-164 (237) alignment 
Range on Protein: 2174-2333
Range on HMM: 6-164/237.0
SNRYRNILATNTNRVRLLGVPPERDYINADHIVFPDEpHDLKYIMAQGPLQATVNDFWTMVAQQGVGTIAMVTQLQEGGRDKCYPYWPQVvGERQTAGDV
 ||| || | . .|| | |   . ||||| ..   |     ||| |||||... .||| || |.    | |.| | || . ||. |||.   . .. | .
knrygnivaydhsrvvlkgagsgsdyinatylkgfdg.tpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywpst.dqpaaygvl

IVEhLsSYSDEFNTVHITELQLYYRSQS---RVVRHCQFLSWPDHGVPSDLEDLVRFQAQVCS
 |  |    .||    .  | | .| .    |..   || ||||.|||     |.||. ..  
tvs.l.kkkeefsdytvrslllskrltlkevrlihqyqftswpdrgvpqqtaallrfrkniin
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 2173-2319 2.6e-27 90.2 In-house 57-205 (305) alignment 
Range on Protein: 2173-2319
Range on HMM: 57-205/305.0
RSNRYRNILATNTNRVRLlGVPPERDYINADHIVFPDEPhDLKYIMAQGPLQATVNDFWTMVAQQGVGTIAMVTQLQEGGRDKCYPYWPQVVGERQTA-G
  |||... . . . |.|   |.  ||| |...  |  | . ..| |||||. |...|| || |. |  | |. .  | |. ||  |||   ||...  .
tknryqdvpcqdqsavkl.dkpspsdyihanyvgcpmip.ekrficaqgpldqtidefwwmviqnkveqivmlcktvelgklkcaqywpaaqgeklelks

DVIVEHLSSY--SDEFNTVHITELQLYY-RSQSRVVRHCQFLSWPDHGVPS
 ..|| .|     .  . ..|| |.| |  .|.  ||| |.  ||| ||| 
givvenvsgskpmerdaeiqitllnltysgdqkmsvrhlqwtewpdrgvpp
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 2155-2319 1.5e-26 88.2 In-house 35-194 (297) alignment 
Range on Protein: 2155-2319
Range on HMM: 35-194/297.0
LDEARPENFSMAKRPGSLRSNRYRNILATNTNRVRLL--GVPPERDYINADHIVFPDEphdlKYIMAQGPLQATVNDFWTMVAQQGVGTIAMVTQLQEGG
| ||   .  .|..   .  .||.||| ....||.|   .  |. ||.|| ..    .    ..|  | | .|||.|||.|| .. | ||.|.....|. 
lpeaniqpqtvaekkvnfeksRYkniLPydssRvkLaivnddpdsDyvnasfvkgnkh....rlittqmPmkatvadfWamvldeqvstivmlnddnerd

RdKCYPYWPQVVgeRQTAGDVIVEHLSSYSDEFNTVHITELQLYYRSQSRVVRHCQFLSWPDHGVPS
. ||  ||..     .| ||| |. ||  . |       |..     . |||.  ||..|||. |. 
k.kcaryWsdkg..vttfGdvsvvllsvsereGfikrelevtkgkakarrvvkqyqfveWPdkaver
0044763 (Phosphotyrosine protein) phosphatases II 2195-2431 2e-26 88.1 In-house 16-169 (178) alignment 
Range on Protein: 2195-2431
Range on HMM: 16-169/178.0
PERDYINADHIVfpdePHdlKYIMAQGPlqatvNDFWTMVAQQGVGTIAMVTQLQEGGRDKCYPYWPQVVGerqtagdvivehlssysdefntvhitelq
.  |||||..|.    |.   |.....|      |.. .. ..|...| ..|. .|.|. ||.||||.  |                             
ersdyinaseil....pg..lylgslpp.....addlellkelgithivnlteelelgflkcdpywpeeag.............................

lyyrsqsrvvRHCQFLSWPDHGVPSDLEDLVRFQAQVCSCCiavpmmlgvvemftamvflqletfqaeMPRPAPLLVHCSAGVGRSGVVVLSDVIANKtr
           . ... .||||||. || . .| . . ..                             ... | ||||||||||||..|. . .     
..........iqylhipipDhgvpdllehflefvefieeal...........................dekggpvlVHCsaGvgRsgtlvaaylmkkl..

kGYipDVRTMVSIVRSQRPmTIQTLEQFTLLYDFALK
 |.  ..   .. ||..||  ... .|   ||.|.|.
.gl..sleeaielvrerRp.ivpnpgqlrqLyefelr
subfamily_CG7180_pd Subfamily CG7180 2170-2434 1.4e-25 84.6 In-house 41-291 (296) alignment 
Range on Protein: 2170-2434
Range on HMM: 41-291/296.0
GSLRSNRYRNILATNTNRVRLLGVP--PERDYINADHIVfpDEPHDLKYIMAQGPLQATVNDFWTMVAQQGVGTIAMVTQLQEGGRdKCYPYWPQVVgeR
  .  ||. ...  . ||| |  .    . ||||| ..      .. .||. ..| . ||..||..| .... .. ..|.  .  . ..  |||.    .
enreknrdvkvvPyDynRvvLekldGeeksdYinavyvd..sflkkkeyivteapkketvdefWrlvydeeisavvvLtktfdfak.mypsywpnks..k

QTAGDVIVEHLSSysDEFNTVHITELQLYYRsqsrvvrhcqFLSWPDHGVPSDLEDL--VRFQAQVCSCCIAVPMM-LGVVEMfTAMVFLQLETFqAEMP
.  |...|| ...  ...  ..| ...|. .           ..  ..  . . |      || ..      ||.   ...|.   .| |  |    | |
eqygeifveivee..kqyanlkirtfkltkk..........ivalteqekqvkaetRivklfqlteWeledkvPlstnaliel.rrrvrlwrekv.dedp

RPAPLLVHCSAGVGRSGVVVLSDVIANKTRKGYIPDVRTMVSIVRSQRPMTIQTLEQFTLLYDFALKKVL
  .|..|..| |..|||| .  |.  .. .|    ||  .|  .| .||  ... |..  .||  |. ||
eegPvvvvssdGasRsGvylaidanlelvekeeevdvFeavktlrrsRpqLvenveeYkyiYdvlleavl
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 2173-2329 2.8e-24 81.0 In-house 63-212 (319) alignment 
Range on Protein: 2173-2329
Range on HMM: 63-212/319.0
RSNRYRNILATNTNRVRLLGVPPE--RDYINADHIVFPDEPHdlKYIMAQGPLQATVNDFWTMVAQQGVGTIAMVTqlqeggRDKCYPYWPQVVGERQTA
  ||. |||| . |.|.|  .  |   ||||| ..     .   ||| |||||. |..||| |. .. . || ..|      .|||  |||. . ...  
dknriinilafdknvvklerliGeefsdyinasfvtGyqrkd..kyiaaqGPldntladfWrmiweyncstivllt......kdkcsqywplkivikeer

GDVIVEHLSsYSDEFNTVHITELQLYYRSQSRVVRHCQFLSWPDHGVPSDLEDLVRFQA
..| |. .   ..|.   .|   .     . | ..   || |||.|||    ||.|.  
fkvkvdsve.etaeyvvrdielsedgkekdirkitqfhflGwpdvGvpdypsdlmrlvk
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 2164-2331 4.2e-24 79.7 In-house 38-161 (392) alignment 
Range on Protein: 2164-2331
Range on HMM: 38-161/392.0
SMAKRPGSLRSNRYRNILATNTNRVRL--LGVPPERDYINADHIVFPDepHDLKYIMAQGPLQATVNDFWTMVAQQGVGTIAMVTQLQEGGrdkcypywp
..|...  |. |||.|||  ...||.|  .   |..||.|| .|   |   .  || .|||  |...||| || |. | ||||||.|.||          
tvaqkeinlkknryknilpydsarvkleviddipdsdylnasyipsfd..nekayiasqgpnaaslddfwrmvfqenvttiamvtklkegd.........

qvvgerqtagdvivehlssysdefntvhitelqlyYRSQSRVVRHCQFLSWPDHGVPSDLEDLVRFQAQV
                                      . | |   .|  |||..||     |..|  .|
...................................kgddartvaqfhftewPdkdvpkhtssllkfikev
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 2174-2330 6.5e-24 79.9 In-house 28-177 (284) alignment 
Range on Protein: 2174-2330
Range on HMM: 28-177/284.0
SNRYRNILATNTNRVRLLGVPPE--RDYINADHIVFPDEPHdlKYIMAQGPLQATVNDFWTMVAQQGVGTIAMVTqlqeggRDKCYPYWPQVVGERQTAG
 ||. .||| . |.|.|  .  |   ||||| .|     ..  ||| .||||. |..||| |. .. . || ..|      .|||  |||. . ...  .
knrighilafdknvvklerliGeefsdyinasfitGyqrkd..kyiatqGPldntladfWrmiweyncstivllt......kdkcsqywplkivikeerf

DVIVEHLSsYSDEFNTVHITELQLYYRSQSRVVRHCQFLSWPDHGVPSDLEDLVRFQAQ
.| |. ..  |.|.   .|   .     . | .|   || |||.|||    ||.|.  .
kvkvdsve.eseeyvvrdielsedgkekdirkirqfhflgwpdvgvpdypsdlmrlvkk
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 2170-2319 1.1e-23 78.7 In-house 40-193 (307) alignment 
Range on Protein: 2170-2319
Range on HMM: 40-193/307.0
GSLRSNRYRNILATNTNRVRLLGVPPERDYINADHIVFPDEPHdlKYIMAQGPLQATVNDFWTMVAQQGVGTIAMVTQLQEGGRDKCYPYWPQVVGERQT
     |||... . . .|. .       ||| |...    .|.  |.| |||||..|. .||.|. |. | .. |. .. | .. ||  ||| . |....
antdknryqdvkcqdkgrivvkfdglasdyihanylgiaikpk..kficaqgplentqysfwamaiqekvesvimlckvielakikceqywpleegqklv

AGD----VIVEHLS--SYSDEFNTVHITELQLYYRSQSRVVRHCQFLSWPDHGVPS
 |.    . |. |     . . . . .|.|.. . ..|| ..| |.  |||.||| 
fgeapntisvanlgakklapdedlinvttlkvdwaqksrtiqhlqwenwpdrgvpq
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 2173-2320 1.4e-23 78.3 In-house 49-192 (287) alignment 
Range on Protein: 2173-2320
Range on HMM: 49-192/287.0
RSNRYRNILATNTNRVRLLGVPPerDYINADHIVFPDEphDLKYIMAQGPLQATVNDFWTMVAQQGVGTIAMVTQLQEGGRDKCYPYWPQVVGerQTAGD
  ||...||  . .|| | |  |  ||||| .|    |  . ..|.|..|.  |. .|| .. .. | .| |..|..|  ...|| |||.      . |.
dknRltqilvpdnyrvllkgehp..dyinavfidgyke..kkafiiaesPmfntarnfWkliddrnvtaivmlcqekendeevcyqyWpeeks..vvlGe

VIVEHLSSYSDEFNTVHITELQLYYRS-QSRVVRHCQFLSWPDHG-VPSD
  .| |.    .  ..   |..   .. . . |.  |. .|...| |.. 
yniellneevnagyierklevknknkagdkqqvkqyqitnWdstgkvtep
0051082 (Phosphotyrosine protein) phosphatases II 2198-2427 3.1e-23 77.5 In-house 4-147 (151) alignment 
Range on Protein: 2198-2427
Range on HMM: 4-147/151.0
DYINADHIVfPDephdlkYIMAQGPLQatvnDFWTMVAQQGVGTIAMVTQLQEGGrdKCYPYWPQVVgerqtagdvivehlssysdefntvhitelqlyy
||||.  .  .       ..  .|||.    ||. .....|. || ......| |  .|. |.|.                                   
dyinfsyvt.gg......lyrsggpla....dflellkelgiktivnlrseeerg..ycpeylpelg.................................

rsqsRVVRHCQFLSWPDHGVPSDLEDLVRFQAQVCScciavpmmlgvvemftamvflqletfqaemPRPAPLLVHCSAGVGRSGVVVLSDVIANKtrkgy
    . |.|...|.|||.|.|  .. ...|  .. .                              ... |.|||||||.||.|..|. . .. .     
....ievlhipildwpdpglplsfdavleflellld..............................kkngpvlvHCsaGkgRTGtlvalylmllg.....

iPDVRTMVSIVRSQRPMTIQTLEQFTLLYD
  .. . .. .|..||. .|. .|| ... 
.vsleealeeyrlkrpgvvqpnqqflfqlf
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 2165-2318 1.2e-22 75.1 In-house 40-195 (290) alignment 
Range on Protein: 2165-2318
Range on HMM: 40-195/290.0
MAKRPGSLRSNRYRNILATNTNRVRLLGVPPERD----YINADHIVfpDEPHDLKYIMAQGPLQATVNDFWTMVAQQGVGTIAMVTQLQEGGRDKCYPYW
..  . . . ||..||. .. ||. |  .. ..|    |||| .|   .  .. .||..|||.. |. ||| .. |. |  | |.|. .| |..||. ||
vgltssnkllnRfanivvyddnritLrpisghkDCtneyinAcyik..gykekkqyiatqgpvsntlvdFWkliwqekvtiivmltniieegkvkCqqYW

PQVVGERqtAGDVIVEHLSSYSDEFNTVHITELQLYYR-SQSRVVRHCQFLSWPDHG-VP
|.   ..   | . .. |.  . .  .    |..      ... | . |. .|...| |.
pdsdtka..ygefsikllneetlneyierklevknknsagakqsvtqyqitnwdstgkvt
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 2174-2335 2.7e-22 74.1 In-house 46-204 (288) alignment 
Range on Protein: 2174-2335
Range on HMM: 46-204/288.0
SNRYRNILATNTNRVRLLgvpPERDYINADHiVFPDEPHDLKYIMAQGPLQATVNDFWTMVAQQGVGTIAMVTQLQEGGRDKCYPYWPQVVGERQTAGDV
 .||.|.   .. ||.|     . |.  | . |.. .... . | || ||..|.. .| |. ...|  | |...| | |..|   |.| ..||.   | .
rdryenlprcditrvkls...ddpdfyiaan.vvssakykrrlicaqaPlngtieelWkmllesdveyivmlcellekGkeksaeyfPsklGekarigrl

IVEHLSSYSDEFNTVHITELQLYYRSQSRV-VRHCQFLSWPDHGVPSDLEDLVRFQAQVCSCC
      ...|   .|... |.     . .| |..  .| |.|.||| .    .|.   . |. 
ctvvkkkradidklvkvsllriskegeekvivkilhlleWdddgvPenylsplrllevlkslq
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 2172-2327 4.4e-22 73.1 In-house 57-208 (290) alignment 
Range on Protein: 2172-2327
Range on HMM: 57-208/290.0
LRSNRYRNILATNTNRVRLLGvPPERDYINADHIvfpdEPHDLKYIMAQGPLQATVNDFWTMVAQQGVGTIAMVTQLQEGGRDKCYPYWPQVVGERQTAG
.. |||...   .  || |     . ||. |...    .  .  .|..||.|..|| |.| || |..| .| |. .| | |. || .|.|.  ||  | |
fkknrykdvvcndktrvilkd.GydGdyvhanyv....kGlkamfiltqGalkdtvidiwrmvlqekvaaivmlceliedGkakceqyypekeGevltfG

DVIVEHLS-SYSDEFNTVHITELQLYYRSQSRVVRHCQFLSWPDHGVPSDLEDLVRF
.. |     .  |.    ..  ..     .. ...| .  ||||. |.     |.| 
eitvlcseeddkdaniikktlsvrdkdsGkehklkhlkikswpdksvalstlallrt
PTPc_DSPc_SM00012 2304-2429 8e-22 72.8 In-house 2-103 (105) alignment 
Range on Protein: 2304-2429
Range on HMM: 2-103/105.0
VRHCQFLSWPDHGVPSDLEDLVRFQAQVCSCCIAVPMmlgvvemftamvflqletfqaemprPAPLLVHCSAGVGRSGVVVLSDVIANKTRKG-YIPDVR
|.| ....|||||||.. ...... ..| ..  .                             .|..|||||||||.|..|. |.. .. .|. . .|. 
vkhyhytgwpdhgvPeesdsilellravkknknkses.........................skpvvVhCsaGvgRtgtfvaldillqqleketkevdif

TMVSIVRSQRPMTIQTLEQFTLLYDFA
 .|. .|.||| ..||.||.  ||.  
qivkelrkqRpgmvqteeqylflyral
0048076 (Phosphotyrosine protein) phosphatases II 2258-2430 2.4e-20 68.1 In-house 1-140 (145) alignment 
Range on Protein: 2258-2430
Range on HMM: 1-140/145.0
PYWPQVVGERQTAGDVIVEHLSSYSDEFNTVHITELQLYYRSQSRVVRHCQFLSWPDHGVPSDLEDLVRFQAQVcscciavpmmlgvvemftamvflqle
||||. . ..   |.. . .   .  ...  ..  |  . .  .| . . ..|.|||||||..||.| .| ...                          
pywpseilpglylgslptaldlellkdlgittvlnltselellerlgiqylylpwpDhgvpdllellleflefi..........................

tfQAEMPRPAPLLVHCSAGVGRSGVVVLSDVIANktrKGyiPDVRTMVSIVRSQRPMTIQTLEQFTLLYDFAL
  .. .... | ||||||||||.|..|. ...     .|   ..   .  ||||||. ... .|.  ||.| |
..eealkeggpvlVHCsaGvgRtgtlvaaylmll...lg..vsleealelvrsqrpgavpnpgqlrflyefel
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 2167-2318 6.1e-20 66.1 In-house 36-204 (301) alignment 
Range on Protein: 2167-2318
Range on HMM: 36-204/301.0
KRPGSLRSNRYRNILATNTNRVRLLGVPP----ERDYINADHIVfpDEPHDLKYIMAQGPLQATVNDFWTMVAQQGVGTIAMVTQLQEGGRDKCYPYWPQ
 .    . ||..||   . ||. |   |     .|.|||| .|   .  .  |.|.||||.. |. ||| .. |. . .| |||.|.|| ..||. |||.
lseenkalnrfknitvyddnriilkpkpnldlcqreyinasyid..gysekkkfiaaqgpmkktlvdfWrliwqekpvsivmvtnlkegtkskceqywpn

VVGERQTAGDVIVEHLSSY--------------SDEFN-TVHITELQLYYRSQSRVVRHCQFLSWPDHGVP
   |... | . |.  ...               | .| .  . ...   . .|. |   |  .||..|| 
seaeseefgpftvtlvneqvyPdfvirqlnvkiqdgsnngyierkfkvksdksswdvlqlqvtdWpqdGvv
subfamily_ptpA1_pd Subfamily ptpA1 2145-2322 3.4e-19 63.9 In-house 21-206 (418) alignment 
Range on Protein: 2145-2322
Range on HMM: 21-206/418.0
HALEAEKDLLLDEARPENFSMAKRPGSLRSNRYRNILATNTNRVRLLGVPP--ERDYINADHIvfpDEPHDLKYIMAQGPLQATVNDFWTMVAQQGVGTI
| .. |  || .   | . |   .      ||| |||  |  ||.|  .      |||||..|   |  .  ..| .||||  |. ||| || .. .  |
hkikeefrlleesvgpsetsegdkkhntsknrytnilpvnhtrvqlkkiqdkegsdyinanyi...dgaypkqfictqgplpntiadfwrmvwenrcrii

AMVTQLQEGGRDKCYPYWPQVVGERQTA---------GDVIVEHLSSYSDEFNTVHITELQLYYRSQSRVVRHCQFLSWPDHGVPSDLE
 |...  |  | ||  |||. .|  | .         |   || .    |    .   ...| .  ..| . . |.  |||| .|   .
vmlsresencrikcdrywpeqiggeqfsiygngnevfgtysvelveviqdpereiitrnirltfegetrditqyqyegwpdhnipdhtq
subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 2167-2328 6.1e-19 62.7 In-house 33-193 (281) alignment 
Range on Protein: 2167-2328
Range on HMM: 33-193/281.0
KRPGSLRSNRYRNILATNTNRVRLLG-VPP--ERDYINADHIVFPDepHDLKYIMAQGPLQATVNDFWTMVAQQGVGTIAMVTQLQEGGRDKCYPYWPQV
..|   . ||| || . .  ||.|   .|     ||| |..|  |       ||..||| . |  ||| |. |.   .| |. |. |  |.||  |.|. 
nqpvnnkknrylnipcldisrvqlkvkmpnknstdyihanyirspf..lkrgyiltqgpkketradfwrmiwqenttaivmlcqfletnrekcaeyfprn

VGERQTAGDVIVEHLSSYSDefNTVHITELQLYYRSQSRVVRHCQFLSWPDHGVPSDLEDLVRFQ
         . |..  |  .  ...  | |.| |  ..|.. |  .  |||  ||   | ...  
ahcclqfdklsvsyedstvn..kslvttrlnlsyegetrlithwlwkewpdwqvpessevmlkil
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 2173-2324 1.1e-18 62.0 In-house 50-208 (305) alignment 
Range on Protein: 2173-2324
Range on HMM: 50-208/305.0
RSNRYRNILATNTNRVRLLGVPPeRDYINADHIVFPDEPHdlKYIMAQGPLQATVNDFWTMVAQQGVGTIAMVTQLQEGGRDKCYPYWPQVVGE----RQ
  |||...   . |||.| |  |  .|| |...  | .|.  ..| .| ||. |  ||| |  |. | .| |. .|.| |  ||. |..   ..    ..
gknrykdvgcldnnrvklegpwp.heyihanyvstptnpk..rfictqaplektcadfwymclqdkveaifmlcnllekgakkcleyfaskdkdvlefee

TAGDVIVEHLSSYSDEFNT---VHITELQLYY---RSQSRVVRHCQFLSWPDHGVPSDLEDL
    ..|   || . .|..    ..|| .|      ...| | |  .  ||| |||.    .
kgqkisvkfessvtlkfrkdakakvtetvlviegpgekarkvthyhwidwpdrgvpaadlai
0048179 (Phosphotyrosine protein) phosphatases II 2285-2428 7.5e-18 60.1 In-house 28-140 (144) alignment 
Range on Protein: 2285-2428
Range on HMM: 28-140/144.0
FNTVHITELQ--LYYRSQSRVVRHCQFLSWPDHGVPSDLEDLVRFQAQVCSCciavpmmlgvvemftamvflqletfqaeMPRPAPLLVHCSAGVGRSGV
..  ..  |.   .. .  | . . ..|.|||||||..||.| .| . . ..                            .... | ||||||||||.|.
lgittvinlteeyepefleregiqylhlpwpDhgvpdllellleflefieea............................leeggpvlVHCsaGvgRtgt

VVLSDVIAnktRKGyiPDVRTMVSIVRSQRPMTIQTLEQFTLLYDF
.|. ...    ..|   ..   .  |||.||. ... .|.  |...
lvaaylmk...klg..lsleealalvrsrrpgavpnpgqlrfLley
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 2171-2263 9.9e-18 59.0 In-house 47-153 (350) alignment 
Range on Protein: 2171-2263
Range on HMM: 47-153/350.0
SLRSNRYRNILATNTNRVRLL-GV---------PPERDYINADHIVFP----DEPHDLKYIMAQGPLQATVNDFWTMVAQQGVGTIAMVTQLQEGGRDKC
.   |||.|||  . .||.|  ..             |||||...  .    .   | ||| .|.||. ||.||.... . .|  | ..|...| ...||
lfaknrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvkvilsltsdvelnlekc

YPYWPQV
| ||.. 
yrYWqeg
subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 2172-2291 2.8e-17 57.2 In-house 53-170 (310) alignment 
Range on Protein: 2172-2291
Range on HMM: 53-170/310.0
LRSNRYRNILATNTNRVRLL-GVPPERDYINADHIVFpdEPHDLKYIMAQGPLQATVNDFWTMVAQQGVGTIAMVTQLQEGGRDKCYPYWPQvVGERQTA
.  ||| ...  .| ||.|        ||| |...    .     .| .||||| |. ||| |. |.   .| .. .  | || ||  |||  .|  .| 
mhknrysdvvcldtsrvklkidksryedyihanyvkt..nylrstficsqgplqhtiidfwrmifqeraesilllckvgeegrpkcvgywps.lgvtety

GDVIVEHLSSYSDEFNTVHIT
| . |  ||  |.||. . ..
gcirvtnlsesseefeicnla
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 2172-2320 6.6e-17 56.5 In-house 9-155 (239) alignment 
Range on Protein: 2172-2320
Range on HMM: 9-155/239.0
LRSNRYRNILATNTNRVRL--LGVPPERDYINADHIVFPDEpHDLKYIMAQGPLQATVNDFWTMVAQQGVGTIAMVTQLQEGGRDKCYPYWPQVVGeRQT
   ||| ||.. . .|| |  |   |  ||||| ..   |      || .|| ....  ||| |. |.    | |.| | || . ||. |||.    .  
kaknryanivtydhsrvvleklsndphsdyinasylrdydg.spkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdsts.kyc

AGDVIVEHLSSYSDEFNTVHIteLQLYYRSQSRVVRHCQFLSWPDHGVPSD
   | . .   ..|      .  .    ... | | . .|  |||.|||  
nlrvtlrktevfadyiirtfv..msqvgqteeryvyqyhftvwpdkgvpqy
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 2173-2320 7.5e-17 56.3 In-house 9-154 (239) alignment 
Range on Protein: 2173-2320
Range on HMM: 9-154/239.0
RSNRYRNILATNTNRVRL--LGVPPERDYINADHIVFPDEpHDLKYIMAQGPLQATVNDFWTMVAQQGVGTIAMVTQLQEGGRDKCYPYWPQVVGeRQTA
  ||| ||.. . .|| |  |   |  ||||| ..   |      || .|| ....  ||| |. |.    | |.| | || . ||. |||.    .   
aknryanivtydhsrvvleklsndphsdyinasylrdydg.spkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdsts.kycn

GDVIVEHLSSYSDEFNTVHIteLQLYYRSQSRVVRHCQFLSWPDHGVPSD
  | . .   ..|      .  .    ... | | . .|  |||.|||  
lrvtlrktevfadyiirtfv..msqvgqteeryvyqyhftvwpdkgvpqy
subfamily_CG42327_pd Subfamily CG42327 2174-2331 2.3e-16 54.4 In-house 31-190 (319) alignment 
Range on Protein: 2174-2331
Range on HMM: 31-190/319.0
SNRYRNILATNTNRVRL--LGVPPERDYINADHIVFPDEPHDlKYIMAQGPLQATVNDFWTMVAQQGVGTIAMVTQLQEGGRDKCYPYWPQVVG--ERQT
 .|. |..     || |   |  ..  |..|...  .|. .   || || .|. .  ||| .| .|   .|  .|.|.| | ..|  |.|   .  ....
ksrvinvvPlPetrvvlqrigdddkdeyldasyvrGyddapn.syiaaqvsledsssdfwrtvweqqsrvivqltdlselGikvcaeylPtketldntsl

AGDVIVEHLSSYSDEFNTVHITELQLYYRSQSRVVRHCQFlSWPDHGVPSDLEDLVRFQAQV
 ||. |      ...   .    |.   ...|| . |  .  |.. .||.. . |.    .|
yGdilvtlkgrevkdryaistlllkrvdkeesrelthywy.kwleaevPaeeaaliamllev
subfamily_eak_pd Subfamily eak 2164-2434 1e-15 52.0 In-house 45-306 (332) alignment 
Range on Protein: 2164-2434
Range on HMM: 45-306/332.0
SMAKRPGSLRSNrYRNILATNTNRVRLLGVPPERD-YINADHIVFPDEPHdlKYIMAQGPLQATVNDFWTMVAQQGVGTIAMVTQLQEGGRDKCYPYWPQ
| ..|  ... |   .|.  . . |||     .|. ||||  . |..  .  |||..  . .  |  || || .|   .| .. .  | . .|   |.|.
setarleavnrn.vvkivpydrylvrltssqlnrlGyinaslaefsevGr..kyiltGiasedkvfafwqmvleqkspaivqlledvelkleksdkyfpd

VVGERQTAGDVIVEHlSSYsDEFNTVHITELQLYYRSQSRVVRHCQFLSWPDHGVPSdLEDLVRFQAQVCSccIAVPMMlgvVEMFTAMVFLQLETFQAE
   |    | . ||   ..  . | ..   |.|    ..  | | ..  | .  .|  .||.. ..  .    . |...   . | .|..   |  ..  
ktreelkfGildver.kef.vkrniletrllelskGnethrvlhykvfGwtettlpk.yedflalrkvmke..vGvlll...ivmksallsstlkkyiht

MPRPAPLlVHCSAGVGRSGVVVLSDVIAN--KTRKGYIPDVRTMVSIVRSQRPMTIQTLEQFTLLYDFALKKVL
 |  ||. . .. |  |.|| |. |.. .    .|     |  ..  |.|.|  .. .  | ...|.  |. .|
ppsfapi.iqsarGsaraGvfvvidllirlidnkkknlysvedlilkvkskrihsvlvalqhsfiyeivldyll
subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 2197-2320 1.2e-15 52.1 In-house 75-199 (301) alignment 
Range on Protein: 2197-2320
Range on HMM: 75-199/301.0
RDYINADHIVFPDEPHdlKYIMAQGPLQATVNDFWTMVAQQGVGTIAMVTQLQEGGRDKCYPYWPQVVGERQTAGDVIVEHLSSY---SDEFNTVHITEL
|  | |. |  . .||  ..| .||||..| .|||.|. |  | .|.|..|  |   .||  | |. ..|.   |   ..  ..    ... .  ..   
rvPihanwiptsGhph..rfiatqgPlkntsedfwamlvqydvekivmlgqkvekleekceeylpvkisekldigrfkikiknkelilnkkiskrtleve

QLYYRSQSRVVRHCQFLSWPDHGVPSD
    . ..| | | |. .|.|.|||  
dstgkfatrtvthyqysewtdrgvPks
subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 2174-2326 1.5e-15 52.0 In-house 38-191 (285) alignment 
Range on Protein: 2174-2326
Range on HMM: 38-191/285.0
SNRYRNILATNTNRVRLLGvpPERDYINADHIVFPDEPhDLKYIMAQGPLQATVNDFWTMVAQQGVGTIAMVTQLQEGGRDKCYPYWPQVVGERQTAGDV
 ||| .. . .  || |     .|||| |  . .| .  .  || .||||  |..||| |. |. .  . |.  | ||| .||  |.|. .||    |  
lnryadvrcieetrvvlkn..hdrdyihaswmrmpgkd.qstyittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekcalyypeklgevvkfgky

IVEHLSSYSDEF-----NTVHITELQlYYRSQSRVVRHCQFLSWPDHGVPSDLEDLVR
 .       .       |.. ... .    |.   . | |   |||.  | |   .. 
eitlteckeeaiagtilnaltvinte.dasseplymnhvqvpwwpdqlapedarpmie
subfamily_egg_pd Subfamily egg 2198-2429 1.5e-14 48.4 In-house 69-266 (307) alignment 
Range on Protein: 2198-2429
Range on HMM: 69-266/307.0
DYINADHIVfpDEPHDLKYIMAQGPLQATVNDFWTMVAQQGVGTIAMVTQLQEGgrDKCYPYWPQVVGERQTA--GDVIVEHLSSYSDEFNTVHITELQL
|.| |...    .|   ..|.|| ||. ||.||| || |. |  | |.|  .|   ..|  |||.   .      | . .| |  .|      ..|.|.|
dfihanrvk..Gkpllnefilaqaplkntvddfwrmvfqeevqyivmltsrkes..erceyywpkaesdslvtvpGslrienlkvdskadplfrvtklkl

YYRSqsrvvrhcqflswpdhgvpsdledlvrfqaqvcSCCIAVPMMLGVVEMFtAMVFLQLETFQAEMPRPAPLLVHCSAGVGRSGVVVLSDVIANKTRK
                                          .    | |.   . |.  |. ..       | .|..  || .....|  ..   .  .
vGgd.................................deerflehwqgdvnns.sdvysplrvlrklrnlskpvvvqdilGvskaatlvaieiallsllr

GYIP--DVRTMVSIVRSQRPMTIQTLEQFTLLYDFA
| |    |.  |  .| .|......  .. ..|   
Gpitkslvlravvflrlrrrlsvesvllylfvyrlv
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 2343-2429 4.5e-14 47.3 In-house 192-279 (305) alignment 
Range on Protein: 2343-2429
Range on HMM: 192-279/305.0
GVVEMFTAMVFLQLETFQAEMPR-PAPLLVHCSAGVGRSGVVVLSDVIANKTRKGYIPDVRTMVSIVRSQRPMTIQTLEQFTLLYDFA
||... |... |  .  .. .     ||||||||||||.|| .  |.  .. .|  . ||  ..  .||.|.  .|||.|.. |.|  
GvpqfatsllslikrvqkdqkkdkgvpllVhCsagvgRtGvfiavdialerlkkEevvdvfevlkqlRskrmkmvqtldqYvflhdal
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 2357-2433 7e-14 46.6 In-house 164-242 (250) alignment 
Range on Protein: 2357-2433
Range on HMM: 164-242/250.0
ETFQAEMPR--PAPLLVHCSAGVGRSGVVVLSDVIANKTRKGYIPDVRTMVSIVRSQRPMTIQTLEQFTLLYDFALKKV
.  ||. ..   ||..|.|||||||||  .  | . .. .|  . ||. .. ..| .|| ....|||.  .|  .|| .
kkvqasqqqagnaPvivqCsaGvgrsGafiaidavlerlkkekvvdvfkvikvlrkdrphavesleqyvfvyeiilkal
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 2364-2433 7.2e-14 46.6 In-house 214-283 (319) alignment 
Range on Protein: 2364-2433
Range on HMM: 214-283/319.0
PRPAPLLVHCSAGVGRSGVVVLSDVIANKTRKGYIPDVRTMVSIVRSQRPMTIQTLEQFTLLYDFALKKV
.   |. ||||||||| |  .  |.. .. ..  . || ..|| .| ||.. .|. ||....|.  |. |
tqsgPivvhCsaGvGRtGtfivldamlervkeegvlDvfstvsrlRtqRnimvqrpeqYkfiyealleav
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 2367-2433 8.1e-14 45.6 In-house 210-276 (515) alignment 
Range on Protein: 2367-2433
Range on HMM: 210-276/515.0
APLLVHCSAGVGRSGVVVLSDVIANKTRKGYIPDVRTMVSIVRSQRPMTIQTLEQFTLLYDFALKKV
 ||..|||||||| |||.  | .  . ... . ||  .| ..| .||  .|| ||....|.  | ..
hpliihcsaGvGrtGvvisidsvvahakttrmvdvfnfvtnirqkrpylvqtqeqyafiygavledl
subfamily_PTPN12_pd Subfamily PTPN12 2364-2428 9.1e-14 46.0 In-house 205-272 (290) alignment 
Range on Protein: 2364-2428
Range on HMM: 205-272/290.0
PRPAPLLVHCSAGVGRSGVVVLSDVIANKTRKGYIP---DVRTMVSIVRSQRPMTIQTLEQFTLLYDF
   |||.||||||||| |...  | . .  ... ||   ||  .|  .| ||.  .|| ||..|.|  
sedaPlvvhCsaGvGrtGtiiaidyvrellkaekipeeldvfdlvlelrkqraalvqtkeqyelvyka
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 2364-2432 9.3e-14 46.2 In-house 211-279 (318) alignment 
Range on Protein: 2364-2432
Range on HMM: 211-279/318.0
PRPAPLLVHCSAGVGRSGVVVLSDVIANKTRKGYIPDVRTMVSIVRSQRPMTIQTLEQFTLLYDFALKK
.   |..||||||||| || .  |.. .. ..  . ||  .|. .|.||.. .|| .|....||  |. 
sgagpivvhCsaGvGrtGvfiavdillerikaealvDvfqtvkqlreqrnlmvqtedqyefiydvllea
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 2366-2433 2.9e-13 44.4 In-house 210-277 (315) alignment 
Range on Protein: 2366-2433
Range on HMM: 210-277/315.0
PAPLLVHCSAGVGRSGVVVLSDVIANKTRKGYIPDVRTMVSIVRSQRPMTIQTLEQFTLLYDFALKKV
  .|||||||||||.|||.  | . .. ...   ||  .| ..|..||  .|| |.....||  |...
efsllvhcsaGvGrtGvvisidevvaqikrtrsvdvfnfvknlrakrpylvqteeeyafiydavledl
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 2367-2434 3.6e-13 44.3 In-house 218-285 (297) alignment 
Range on Protein: 2367-2434
Range on HMM: 218-285/297.0
APLLVHCSAGVGRSGVVV-LSDVIANKTRKGYIpDVRTMVSIVRSQRPMTIQTLEQFTLLYDFALKKVL
.||||||.||||| ||.. . .|.|.  |.  . |.  .|. .| .||  .|| ||....|   |. .|
gPllvhclaGvGrtgvlltidsvvaeakrekev.difglvkklrqerpylvqtkeqykfvyvavleall
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 2173-2329 4.8e-13 43.3 In-house 50-201 (439) alignment 
Range on Protein: 2173-2329
Range on HMM: 50-201/439.0
RSNRYRNILATNTNRVRLLGVP--PERDYINADHIVFPdePHDLKYIMAQGPLQATVNDFWTMVAQQGVGTIAMVTQLQEGGRdkcypYWPQvvGERQTA
  |||... | .  || |  .|  |   ||||..|       |  || .||| . |..||| .| .. . || |.|.| |  .     |||    .    
tknrykdvgafdhtrvtlqeipgvphshyinanyikGy..yddklyiatqgpkkettddfwrlviekktvtivmltnlvesyk.....ywps..daevcy

GDVIVEHlsSYSDEFNTVHITELQLYYR----SQSRVVRHCQFLSWPDHGVPSDLEDLVRFQA
||..|        |.    |  .... .     . | | . ....|||. ||..   .. |  
gdiavrv..drnielpnyvirgfkvfnerdttekertvlqfhyiawpdknvpaqashvldflr
subfamily_PTPRB_pd Subfamily PTPRB 2357-2430 1.1e-12 42.6 In-house 209-282 (293) alignment 
Range on Protein: 2357-2430
Range on HMM: 209-282/293.0
ETFQAEMPRPAPLLVHCSAGVGRSGVVVLSDVIANKTRKGYIPDVRTMVSIVRSQRPMTIQTLEQFTLLYDFAL
.. . .  . .|..|||||||||.|. .  | . .. ..  . |. ..|. .|..| . .|| .|.  ...  |
reaiektaskrPivvhCsaGvGRtGtfialdrllqaieeedyvdifgivaelReeRnllvqtekqYifihqcvl
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 2348-2432 1.2e-12 42.5 In-house 189-275 (281) alignment 
Range on Protein: 2348-2432
Range on HMM: 189-275/281.0
FTAMVFLQLETFQAEMPRP-APLLVHCSAGVGRSGVVVLSDVIANKT-RKGYIPDVRTMVSIVRSQRPMTIQTLEQFTLLYDFALKK
 ....  . |  ... ..  |||..||||||||.|. .  | ....  ..    ||. .|  .| .| . .||. |.. .|   |. 
tkellefrkevlkltekktkaplvihCsaGvGrtGtyialDrlvkaveaeleeldvkavvaelrkernlmvqtvvqyefvykavlda
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 2367-2434 1.4e-12 41.7 In-house 169-237 (392) alignment 
Range on Protein: 2367-2434
Range on HMM: 169-237/392.0
A-PLLVHCSAGVGRSGVVVLSDVIANKTRKGYIPDVRTMVSIVRSQRPMTIQTLEQFTLLYDFALKKVL
. ||..||||||||.|||.  | .  ...|  . ||  .|. .| .||. .|| ||....|   |. .|
thpliihcsagvgrtgvvisidsvvahakktrmvdvfnfvtnirrkrpymvqtkeqyafiygavledll
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 2366-2432 2.5e-12 41.6 In-house 223-289 (298) alignment 
Range on Protein: 2366-2432
Range on HMM: 223-289/298.0
PAPLLVHCSAGVGRSGVVVLSDVIANKTRKGYIPDVRTMVSIVRSQRPMTIQTLEQFTLLYDFALKK
 .|..|.|||||||||  .  | . .. .|    ||. .| ..| .|| ..|| ||.. .|.  |. 
nkpvivqCsaGvgRsGtfiaidsvlervkkeqvvDvfqvvkvlRkkrpgavqteeqYvfiyeavlea
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 2174-2301 3.1e-12 41.1 In-house 36-154 (267) alignment 
Range on Protein: 2174-2301
Range on HMM: 36-154/267.0
SNRYRNILATNTNRVRLLGvpPERDYINADHIVFPDepHDLKYIMAQGPLQATVNDFWTMVAQQGVGTIAMVTQLqegGRDKCYPYWPQVVGERQTAGDV
 ||. . |  . .|| |     |..|||| ..         ..|. |.||. |. ||.|.. .|.| .| ..|.    . |.   .||  .|. .   |.
rnrlddnlpyddtrvilrt..keeeyinasyvegyk..tknafivtqdplkntitdfltvihdqkvpvivlltkv...ftdnirlfwPPkmgqakkyqdl

IVEHlsSYSDEFNTVHITELQLYYRSQS
 |||  |   | |  .|  |.| .. .|
tveh..slekeendyqiitlelkfknes
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 2366-2435 3.3e-12 40.7 In-house 226-294 (301) alignment 
Range on Protein: 2366-2435
Range on HMM: 226-294/301.0
PAPLLVHCSAGVGRSGVVVLSDVIANKTRKGYIPDVRTMVSIVRSQRPMTIQTLEQFTLLYDFaLKKVLE
 .|..||||..|.|||| .  ..     .   . ||  ..  || ..|  ..||||.| .||  ... |.
ggpvvVHCSdtVsrsGvYcsvsiglEQckaegVVdvfqvtkavrrskpgaVtTLeqytsiydv.idmylq
subfamily_PTPN13_pd Subfamily PTPN13 2364-2431 3.8e-12 41.1 In-house 199-267 (273) alignment 
Range on Protein: 2364-2431
Range on HMM: 199-267/273.0
PR-PAPLLVHCSAGVGRSGVVVLSDVIANKTRKGYIPDVRTMVSIVRSQRPMTIQTLEQFTLLYDFALK
 .  .|..||||||.||||...  ||. .   .    ||. .|  .| ||   .|| .|. . |  .|.
qtdagPivvhcsaGiGrsGtlitidvvlglierdkefdvkeivrklreqrqgvvqtkdqyifvykaile
subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 2175-2327 4.1e-12 40.4 In-house 47-201 (312) alignment 
Range on Protein: 2175-2327
Range on HMM: 47-201/312.0
NRYRNILATNTNRVRLLGvpPERDYINADHIVFPDEPHdlKYIMAQGPLQATVNDFWTMVAQQGVGTIAMVTQLQEGGRDKCYPYWPQVVGERQTAGD-V
||| ||   .  |  | |   |  || |. .     |   ... .||||. |.  || ..   |  .| ... . | | .||  |  ..||  .     |
nrypniqcwdrgrftlag..denfyihanfvkictkpe..rfvctqgplentcthfwqlalslgstsiillcgfvedgsekcakyisdivgfvdledhrv

IVE-----HLSSYSDEFNTVHITELQLYYRSQSRVVRHCQFLSWPDHGVPSDLEDLVRF
  |      .   | .  |  .  . .    |   . | |. ||||||.|   .   |.
yteycteieiggkskdkithrvlkvvvkatgqesklnhyqwaswpdhgmpdscdtalrl
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 2366-2430 1.1e-11 39.3 In-house 212-276 (288) alignment 
Range on Protein: 2366-2430
Range on HMM: 212-276/288.0
PAPLLVHCSAGVGRSGVVVLSDVIANKTRKGYIPDVRTMVSIVRSQRPMTIQTLEQFTLLYDFAL
  |..|||||||||.|. .  | . .. ..    ||  .|. .| ||.. .|||.|.  .|.  |
tgpiivhCsaGvGrtgtFialdalidaveeedyiDvagtvaklRkqRallvqtlkqYefiyevll
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 2364-2436 1.6e-11 38.7 In-house 214-286 (290) alignment 
Range on Protein: 2364-2436
Range on HMM: 214-286/290.0
PRPAPLLVHCSAGVGRSGVVVLSDVIANKTRKGYIPDVRTMVSIVRSQRPMTIQTLEQFTLLYDFALKKVLEV
.   ...||||..||||.| .  ..  ||...    ||  ..   |.|.| ..|| .|. ....  |. . ..
rgntsivvHCSdtvgrsavfcaaattinkcktegvidvfqvlksqRiqkpgsvqtvqqyqgifqivltyldsf
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 2363-2433 1.7e-11 38.6 In-house 208-278 (287) alignment 
Range on Protein: 2363-2433
Range on HMM: 208-278/287.0
MPRPAPLLVHCSAGVGRSGVVVLSDVIANKTRKGYIPDVRTMVSIVRSQRPMTIQTLEQFTLLYDFALKKV
 .  ....||||..||||.. .  ..  ||...  . ||  ..   | |.| ..|| ||.. ..|  |. .
krgntsivvhCsdtvGrsamfcaaattinkckteGviDvfqvlksqriqkpgsvqtveqykfindivleyl
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 2357-2430 3.7e-11 37.9 In-house 215-288 (319) alignment 
Range on Protein: 2357-2430
Range on HMM: 215-288/319.0
ETFQAEMPRPAPLLVHCSAGVGRSGVVVLSDVIANKTRKGYIPDVRTMVSIVRSQRPMTIQTLEQFTLLYDFAL
. ..  .  .|...|||||||||.|| .  ||. .. ..    ||  .|  .| ||.  .| | |. ..|   |
rhltskenhranivvhcsaGvGrtGvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysall
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 2357-2430 4.9e-11 37.7 In-house 179-252 (284) alignment 
Range on Protein: 2357-2430
Range on HMM: 179-252/284.0
ETFQAEMPRPAPLLVHCSAGVGRSGVVVLSDVIANKTRKGYIPDVRTMVSIVRSQRPMTIQTLEQFTLLYDFAL
. ..  .  .|...|||||||||.|| .  ||. .. ..    ||  .|  .| ||.  .| | |. ..|   |
rhltskenhranivvhcsagvgrtgvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysall
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 2196-2262 5.3e-11 36.4 In-house 89-155 (349) alignment 
Range on Protein: 2196-2262
Range on HMM: 89-155/349.0
ERDYINADHIVFPDEPHDLKYIMAQGPLQATVNDFWTMVAQQGVGTIAMVTQLQEGGRDKCYPYWPQ
  |||||... ..    . |||  | || .||.||....  .||  .  ... .| . .||. || .
lddyinanylkltrisvekkyiatqaPlPstvddfykvillngvklvlsLnddkelslekcdiywqe
subfamily_PTPRN_pd Subfamily PTPRN 2365-2431 5.4e-11 36.8 In-house 223-290 (297) alignment 
Range on Protein: 2365-2431
Range on HMM: 223-290/297.0
RPAPLLVHCSAGVGRSGVVVLSDVIANKTRKGYI-PDVRTMVSIVRSQRPMTIQTLEQFTLLYDFALK
| .|..||||.|.||.|| .| |.. |.  ||    |. . .  .| |||  ..| .|| . .    .
rscpivvhcsdGaGrtGvyilidlvlnrllkGvkeidiaatlehlrdqrpglvktkdqfefaltavae
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 2366-2435 6e-11 36.9 In-house 209-279 (307) alignment 
Range on Protein: 2366-2435
Range on HMM: 209-279/307.0
PAPLLVHCSAGVGRSGVVVLSDVIANKTRKGY-IPDVRTMVSIVRSQRPMTIQTLEQFTLLYDFALKKVLE
  |..||||||||||| .|   .. .|  .|    |.. .|  .||||. .|||  |.  |.   |.  ||
tnpvvvhcsaGvGrsGtivaislvqdkmiaGinckdmkklveelrsqrhyaiqteaqylylhrvlleyfle
subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 2207-2325 9.8e-11 36.2 In-house 26-139 (255) alignment 
Range on Protein: 2207-2325
Range on HMM: 26-139/255.0
FPDEPHDLKYI--MaqgplqaTVNDFWTMVAQQGVGTIAMVTQLQEGGRDKCYPYWPQVVGERQTAGDVIVEHLSSYSDEF-NTVHITeLQLYYRSQSRV
 |. ... | .  .       ||. |. .. |..  ...|.. ..| |..||  |.|    |..   || |    | .|    |..|| ..|  . . . 
kPekdkkrknlysl.......tvdkfyqtivqtktevvvmlcdfaeegvekcssyfplekdeklkladvnvtttkssadvvlrtleit.stlgekkktht

VRHCQFLSWPDHGVPSDLEDLV
|.| ..  |...  | . ... 
vkhysykGWieknaPelareil
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 2216-2315 1.1e-10 35.5 In-house 238-331 (440) alignment 
Range on Protein: 2216-2315
Range on HMM: 238-331/440.0
YIMAQGPLQATVNDFWTMVAQQGVGTIAMVTQLQEggrDKCYPYWPqVVGERQTAGDVIVEHLSsySDEFNTVHITELQLYYRSQSRVVRHCQFLSWPDH
.| .| ||..|| ||| .| .  . || |. ||..     |  ||| |     | |   | |    |...| |..  |.| |. .   .|  .  .||  
fiatqmpldstvldfwrlvhdyristiimlnqlnd...ktcsiywp.vntrsvtfgpftvghkg..senmnrvkvrtlelkykeevheirqfevqtwptw
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 2342-2426 1.2e-10 35.9 In-house 149-233 (239) alignment 
Range on Protein: 2342-2426
Range on HMM: 149-233/239.0
LGVVEMFTAMVFLQLETFQAEMPRPAPLLVHCSAGVGRSGVVVLSDVIANKTRKGYIPDVRTMVSIVRSQRPMTIQTLEQFTLLY
 || .  ||.. |. .  .  .|   | ..||||||||.| ... | .  ...|    |.   |  .| .||  .|| ||. ...
kgvpqyatavlglrrkitkdslpgarpwvihcsagvgrtgaflvidamlrqakkqktvdifnyvkairedrphmvqtseqyvfih
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 2342-2426 1.3e-10 35.9 In-house 150-234 (239) alignment 
Range on Protein: 2342-2426
Range on HMM: 150-234/239.0
LGVVEMFTAMVFLQLETFQAEMPRPAPLLVHCSAGVGRSGVVVLSDVIANKTRKGYIPDVRTMVSIVRSQRPMTIQTLEQFTLLY
 || .  ||.. |. .  .  .|   | ..||||||||.| ... | .  ...|    |.   |  .| .||  .|| ||. ...
kgvpqyatavlglrrkitkdslpgarpwvihcsagvgrtgaflvidamlrqakkqktvdifnyvkairedrphmvqtseqyvfih
subfamily_CG42327_pd Subfamily CG42327 2367-2428 2.1e-10 34.8 In-house 248-310 (319) alignment 
Range on Protein: 2367-2428
Range on HMM: 248-310/319.0
APLLVHCSAGVGRSGVVVLSDVIANKTRKG-YIPDVRTMVSIVRSQRPMTIQTLEQFTLLYDF
 || |||| ||||.|.|. ||.  ..  .     |.  .|| || .|  ...| ||. ..|  
GPlvvhcsdGvGrtGlviasdiairsleeskrsvdiPqlvssvrrdrasavltkeqyefiykv
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 2362-2434 7.5e-10 32.7 In-house 123-195 (440) alignment 
Range on Protein: 2362-2434
Range on HMM: 123-195/440.0
EMPRPAPLLVHCSAGVGRSGVVVLSDVIANKTRKGYIPDVRTMVSIVRSQRPMTIQTLEQFTLLYDFALKKVL
|    .|||||||||.||.||..  | |  ....    |. .... .|..||  .|| ||......  |. .|
ekagngpllvhcsagagrtgviiavdsilreakrsdqidifsfinsmrnnrpqmvqtpeqyafvheavlegll
subfamily_hpo-7_pd Subfamily hpo-7 2206-2324 1.2e-09 32.5 In-house 28-144 (263) alignment 
Range on Protein: 2206-2324
Range on HMM: 28-144/263.0
VFPDEPHDLKYI--MaqgpLQATVNDFWTMVAQQGVGTIAMVTQLQEGGRDKCYPYWPQVVGERQTAGDVIVEHLSSYSDEF-NTVHITElQLYYRSQSR
. |. ... | .  .    |  |.. |. .. |..  ...|..  .| |..||  |.|    |.|   .| |    . ||    | .... .|  . . .
fkPekdkkrknlysl....lvqtidkfyqtivqtktevvvmLcDfneegvekcssyfPlekdekqklanvnvcttkvqsdvllktlells.tlgeKkkth

VVRHCQFLSWPDHGVPSDLEDL
 |.| ..  |...  | . .. 
tvkhysykgWiekndpelarei
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 2367-2432 1.7e-09 31.6 In-house 213-278 (439) alignment 
Range on Protein: 2367-2432
Range on HMM: 213-278/439.0
APLLVHCSAGVGRSGVVVLSDVIANKTRKGYIPDVRTMVSIVRSQRPMTIQTLEQFTLLYDFALKK
 |..|||||||||.| ..  |.  .. .     |.. .|...| ||   .|.| |. ..|.  |. 
gpvvvhcsagvGrtGtiialdialeqlklenkvdikgivkvlrkqrkqmvqalcqyvfiynavled
subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 2215-2318 2.3e-09 31.7 In-house 6-111 (199) alignment 
Range on Protein: 2215-2318
Range on HMM: 6-111/199.0
KYIMAQGPLQATVNDFWTMVAQQGVGTIAMVTQLQEGGRDKCYPYWPQVVGERQTAGD--VIVEHLSSYSDEFNTVHITELQLYYRSQSRVVRHCQFLSW
.|| .| ||. |. ||| || . | | | || . |         ||| .       |   | .. ... .|   |. |   .      .| . | || ||
ryiatqhplretmadfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqftsw

PDHGVP
 ..  |
kekttp
subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 2215-2318 2.3e-09 31.7 In-house 5-110 (198) alignment 
Range on Protein: 2215-2318
Range on HMM: 5-110/198.0
KYIMAQGPLQATVNDFWTMVAQQGVGTIAMVTQLQEGGRDKCYPYWPQVVGERQTAGD--VIVEHLSSYSDEFNTVHITELQLYYRSQSRVVRHCQFLSW
.|| .| ||. |. ||| || . | | | || . |         ||| .       |   | .. ... .|   |. |   .      .| . | || ||
ryiatqhplretladfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqftsw

PDHGVP
 ..  |
kekttp
subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 2196-2326 2.5e-09 31.7 In-house 45-182 (290) alignment 
Range on Protein: 2196-2326
Range on HMM: 45-182/290.0
ERDYINADHIVFPdepHDLKYIMAQGPLQAT-------VNDFWTMVAQQGVGTIAMVTQLQEGGRD----KCYPYWPQVVGERQTAGDVIVEHLSSYSDE
  ||| |... .|   ..|. |. | |....       ...|| |. |  |  . |. . .|  ..     |  | |. |||  . ... |.  |   ..
nddyiHAnrvtcp...nglrliltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCakYvpesvgeelkfkgltvkCkskeked

fnTVHITELQLYYRSQS-RVVRHCQFLSWPDHGVPSDLEDLVR
   | . || . .  .    | | .. .| .  |. |   |. 
..dvetRelvvkfddeeeftvtHsllkgWnklnvqedtktlls
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 2362-2427 2.6e-09 31.7 In-house 168-233 (237) alignment 
Range on Protein: 2362-2427
Range on HMM: 168-233/237.0
EMPRPAPLLVHCSAGVGRSGVVVLSDVIANKTRKGYIPDVRTMVSIVRSQRPMTIQTLEQFTLLYD
 ... .| ..||||||||.|.... | .  ....  . |.   |  .  .||  ||| .|. ....
hvsesgpwiihcsagvgrtgiflvidamlrqakekkvvdiynyvysieedrpyiiqtkdqyvfihq
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 2367-2425 7.7e-09 29.9 In-house 193-251 (267) alignment 
Range on Protein: 2367-2425
Range on HMM: 193-251/267.0
APLLVHCSAGVGRSGVVVLSDVIANKTRKGYIPDVRTMVSIVRSQRPMTIQTLEQFTLL
 ||.|.||.||||||  .  |   .....  . |.  ..  .||||.  ..|.|..  .
rPlvvacsdGvGrsGtflvidsqleraktegvsdifdflrkirsqriglvdtkeryiyi
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 2357-2430 9.3e-09 29.4 In-house 210-284 (305) alignment 
Range on Protein: 2357-2430
Range on HMM: 210-284/305.0
ETFQAEMPRPAPLLVHCSAGVGRSGVVVLSDVIANKTRKGY-IPDVRTMVSIVRSQRPMTIQTLEQFTLLYDFAL
| ..   |   |. ||||||.||.| ||. . | ..   |  | |   ..  .| ||  .||| .|. ....  |
ellekarpskgpivvhcsagigrtgsvvmleyildqllagqiiedtdkilqkireqrnnsiqtdaqylfvhqvil
subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 2221-2321 1.3e-08 28.6 In-house 98-207 (302) alignment 
Range on Protein: 2221-2321
Range on HMM: 98-207/302.0
GPLQATVNDFWTMVAQQGVGTIAMVTQLQEGGRDKCYPYWPQVVGERQTAGDVI------VEHLSSYSDEF----NTVHITELQLYYrSQSRVVRHCQFL
 | . |.. .|... |  |. .. .... |..  || .|. . ||.. . |          ..|. ..|       || |.. .     . . |   .| 
vpkkstlekhwalieqynvaivvqlcsfvedeekkcaeyysdkvggelkfgrytvktvsvktdleeftdkksfklytveiknekkkk.kvkktvdilafs

SWPDHGVPSDL
.||||| | . 
awpdhGapkea
TNFR_c6 TNFR/NGFR cysteine-rich region 567-603 1.4e-08 21.2 Pfam-A 5-39 (39) alignment 
Range on Protein: 567-603
Range on HMM: 5-39/39.0
QYQAPQQArdRVCRTCSTCEEGLYEVAACTTTTNRQC
.|.. ..   | |. ||.||.|...|. || | |..|
tYtdsknh..rqClsCskCepgtvlvspCtetqnTvC
subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 2348-2429 2.8e-08 27.5 In-house 200-281 (302) alignment 
Range on Protein: 2348-2429
Range on HMM: 200-281/302.0
FTAMVFLQLETFQAEMPRPAPLLVHCSAGVGRSGVVVLSDVIANKTRKGYIPDVRTMVSIVRSQRPMTIQTLEQFTLLYDFA
.....    . |. ...  .....    |.|| |...   |  .|  ||  | .  .|  .||||| ....|.|.. ||  .
yaeliktaakvfakkikadentvivSknGaGRagafltlavaveklqkgkepnikeivksiRsqRpravdslkQyvslyial
subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 2364-2429 3.4e-08 27.5 In-house 198-265 (281) alignment 
Range on Protein: 2364-2429
Range on HMM: 198-265/281.0
PRPAPLLVHCSAGVGRSGVVVLSDVIANKTRKG-YIPDVRTMVSIVRS-QRPMTIQTLEQFTLLYDFA
 | .| ..|||||||||| ..  ..  .  .    .||.. .|| .|   |  ..|||.|. |..   
arstppvihcsagvgrsgtlmaveialqsihshftlpdikqivshlrvtgraasvqtlqqymliwkvl
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 2350-2430 3.8e-08 27.4 In-house 246-341 (350) alignment 
Range on Protein: 2350-2430
Range on HMM: 246-341/350.0
AMVFLQLETFQAEMPRPAPLLVHCSAGVGRSGVVVLSDVIAN----------KTRKGYIP-----DVRTMVSIVRSQRPMTIQTLEQFTLLYDFAL
 ..         .  | .|.|||||||||| |..|  | . .          . ||   .      .  .| ..|.||   .|.|.||  .|. .|
dliddlfaeshldnarsspilvhCsaGvGrtGtlvtlDsllsdfeilenltkesrkldvaaktrDlisiivnelrkqrismvqnldqfifiYeall
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 2367-2430 1.2e-07 26.0 In-house 205-268 (288) alignment 
Range on Protein: 2367-2430
Range on HMM: 205-268/288.0
APLLVHCSAGVGRSGVVVLSDVIANKTRKGYIPDVRTMVSIVRSQRPMTIQTLEQFTLLYDFAL
 |..||.||||||.| ..|. ....  |      .|....  | .|  .|||  |.  ..   |
kPivvhssaGvGrtgtlililialeslrlddflgirsllaklreerfkaiqtemqylyvhrcvl
subfamily_PTPN1_pd Subfamily PTPN1 2367-2427 1.2e-07 25.7 In-house 202-265 (290) alignment 
Range on Protein: 2367-2427
Range on HMM: 202-265/290.0
APLLVHCSAGVGRSGVVVLSDVIANKT---RKGYIPDVRTMVSIVRSQRPMTIQTLEQFTLLYD
 | ..|||||.|||| ..| | .  .     .    |.. ..  .|..|   ||| .|. . | 
GpavihcsaGiGrsGtfclvdtclvliekkddlssvdikkvllelrkyrlGliqtadqlrfsyl
TNFR_c6 TNFR/NGFR cysteine-rich region 429-458 1.3e-07 18.1 Pfam-A 9-39 (39) alignment 
Range on Protein: 429-458
Range on HMM: 9-39/39.0
SSN-RLCAPCSECATDQFILQACNETTDTEC
|.| | | .||.|  ...  . |.|| .|.|
sknhrqClsCskCepgtvlvspCtetqnTvC
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 2363-2435 1.3e-07 25.5 In-house 218-291 (305) alignment 
Range on Protein: 2363-2435
Range on HMM: 218-291/305.0
MPRPAPLLVHCSAGVGRSGVVVLSDVIANKT-RKGYIPDVRTMVSIVRSQRPMTIQTLEQFTLLYDFALKKVLE
     |..||||||.||.| .|  . | .|   .   | .  .|  .| || ..||.  |.  ..   |. .||
rgskvpivvhcsagigrtgtivaieyilekiaenkpcppmpelvkalrdqrafsiqndvqylfihrvmlnyfle
subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 2193-2244 3.1e-07 24.2 In-house 66-115 (347) alignment 
Range on Protein: 2193-2244
Range on HMM: 66-115/347.0
VPPERDYINADHIVFPDEphDLKYIMAQGPLQATVNDFWTMVAQQGVGTIAM
  .   |||| || | .   . .||..| ||  || ||| ||    |  .  
addvetyinashikfdna..skeyiltqyplpdtvrdfwkmvsvtkvtqvvt
subfamily_PTPDC1_pd Subfamily PTPDC1 2369-2429 4.2e-07 24.6 In-house 117-172 (182) alignment 
Range on Protein: 2369-2429
Range on HMM: 117-172/182.0
LLVHCSAGVGRSGVVVLSDVIANKTRkgyipDVRTMVSIVRSQRPMTIQTLEQFTLLYDFA
. ||| || || ||.. . .. .|       .    ...|||.|| .||| ||  |. .||
vavhChaGlGrtGvliacylvyakrl.....taekaiklvrskrpksiqtreqvelvkefa
PTEN_1 2369-2429 4.8e-07 24.8 In-house 133-189 (196) alignment 
Range on Protein: 2369-2429
Range on HMM: 133-189/196.0
LLVHCSAGVGRSGVVVLSDVIANKTrkgyiPDVRTMVSIVRSQR-PMTIQTLEQFTLLYDFA
 |||| ||.||||.|| .  .. .       ...  ...||..| |. ... .|  ||. ||
VlVHCkaGlgRsGtvvaayLmykgk.....ltadeAlelvrekRppgapnspsqerlleyfa
subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 2365-2426 9.6e-07 22.6 In-house 222-283 (310) alignment 
Range on Protein: 2365-2426
Range on HMM: 222-283/310.0
RPAPLLVHCSAGVGRSGVVVLSDVIANKTRKGYIPDVRTMVSIVRSQRPMTIQTLEQFTLLY
|  | .||||||..| .|||  ..  .|...|   |.  ... .. .| . |||  |.... 
rhgpcvvhcsagkdrlyvvvalklkidkldrglkvdaeevktellksraiciqtelqyliid
subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 2368-2435 1.6e-06 22.1 In-house 211-274 (312) alignment 
Range on Protein: 2368-2435
Range on HMM: 211-274/312.0
PLLVHCSAGVGRSGVVVLSDVIANKTRKGYIPDVRTMVSIVRSQRPMTIQTLEQFTllydFALKKVLE
|.. ||||||||.| ..| . .    |.    .|. .  ..| .|  ..... |.     .||. |||
pviahcsagvgrtgtlaliesmiaalrhprkqnvkdsfvllrkdrarsvrvfpqyv....yalrcvle
TNFR_c6 TNFR/NGFR cysteine-rich region 365-408 1.8e-06 14.5 Pfam-A 1-39 (39) alignment 
Range on Protein: 365-408
Range on HMM: 1-39/39.0
CAQGfTYESDgptPTTdRECSACLSCSTAEYQLQPCTLTTDRAC
| .| || ..    .. |.| .| .|.  ..  .||| | .. |
Ceeg.tYtds...knh.rqClsCskCepgtvlvspCtetqnTvC
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 2365-2428 3.7e-06 20.8 In-house 215-278 (290) alignment 
Range on Protein: 2365-2428
Range on HMM: 215-278/290.0
RPAPLLVHCSAGVGRSGVVVLSDVIANKTRKGYIPDVRTMVSIVRSQRPMTIQTLEQFTLLYDF
 . |. ||||||.||.|  |  .| ..   .|   |.  .|  .|  |  ..|   |. .| . 
asGpvvvhcsaGiGrtGtfvaievglqilldGkeldlldlvralrnsrlnsvqvdiqylalvei
TNFR_c6 TNFR/NGFR cysteine-rich region 465-507 6.2e-06 12.8 Pfam-A 1-39 (39) alignment 
Range on Protein: 465-507
Range on HMM: 1-39/39.0
CEPGEFREApctpT-AdMRCTACTTCAADQYQVATCTASTDRVC
||.|.. .     .   ..|..|..|  ... |. ||.  ..||
CeegtYtds....knh.rqClsCskCepgtvlvspCtetqnTvC
subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 2369-2438 9.6e-06 19.3 In-house 224-293 (302) alignment 
Range on Protein: 2369-2438
Range on HMM: 224-293/302.0
LLVHCSAGVGRSGVVVLSDVIANKTRKGYIPDVRTMVSIVRSQRPMTIQTLEQFTLLYDFALKKVLEVEG
.||||||||||.| .|      .   |  . |. ..|  ||. |  ..|. .| . |  .  | ..| .|
vlvhcsaGvGrtGtlvaikyGiqlcskkkvtdllsivlpvrqcryGavqdeqqliylllcvtkglmekag