Gene MbrePTP-Un-1 in Monosiga brevicollis

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily PTP-unclassified
Protein sequence
ID Type Fasta BLAST phosphatome Note
MbreP053_AA protein Get Run
MbreP053_AA_561-781 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
0050432 (Phosphotyrosine protein) phosphatases II 15-234 5.7e-74 244.5 In-house 87-301 (308) alignment 
Range on Protein: 15-234
Range on HMM: 87-301/308.0
LhPSPASYINGNWMDGF--SQSREYIVTQGPLPNTIDAFWRMVWEFKVCQIVMITNLKEKGRVKCEKYWPFE--GEQLKIGDLILLCEEVKLHAAFQVAQ
| ... .||| ...||.   ..|..|.||||||||.. ||||||| .|  |||.|.| |.||.||..||| |  |. |..|.. . . ... .. . | .
l.degsdYInAsyvdgyssklprkfIatqgPlpntvedFwrmvweqnvrvIvmLtklvengrekcaqYwplelgggsleygkftvtllseevlddytvrt

LRVVHRHTGVAHTVHHLWFQDWPDHGVPDTTEAVIDLLLTSRELRtralasREqvAPIAVHCSAGIGRSGVFVGCDILLQQAESFGQVDALGALCHMRRA
|....  .|  .||.|... .|||||||. .|...|.|   |. .      ..   ||.||||||.||.|.|. .|.||.| |  | ||...|....|. 
leltnlgdgesrtvthfhytnWpdhgvPpspeilldflelvrksl......pg..gpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReq

RGGCVQTPHQWLYMLLVAHDYLAK
| |.|||| | |..  ....|| .
Rpgmvqtpeqylflyralleylkl
0036941 (Phosphotyrosine protein) phosphatases II 15-235 5.8e-74 244.4 In-house 58-280 (297) alignment 
Range on Protein: 15-235
Range on HMM: 58-280/297.0
LHPSPASYINGNWMDGFSQSREYIVTQGPLPNTIDAFWRMVWEFKVCQIVMITNLKEKGRVKCEKYWPFE-GEQLKIGDLILLCEEVKL--HAAFQVAQL
|.... .|||....||....|..|.||||||||.. ||||||| .|  |||.|.| |.||.||..||| | || |. ||... . .|.   .. . . .|
lddegsdYinAsyvdgydlkrkfIatqgPlpntvedFWrmvweqnvtvIvmltelvelgrekcaqywpleegesltygdftvtllsvevvllddytlrtl

RVVHRHTGVAHTVHHLWFQDWPDHGVPDTTEAVIDLLLTSRELRTRALASreqvAPIAVHCSAGIGRSGVFVGCDILLQQAE---SFGQVDALGALCHMR
.|..  .|  .||.|... .|||||||.... ..|..   |. .  .  .     |. ||||||.||||.|...|..||| |     |.|| | |....|
evtdtgngesrtvthfhytgwpdhgvpespaslldfielvrkvlkllpsg....gpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklR

RARGGCVQTPHQWLYMLLVAHDYLAKV
. | |.|||. |....  .  ..| |.
eqRpgavqtleqyrflyeallellkkk
0046845 (Phosphotyrosine protein) phosphatases II 18-234 2.4e-73 242.3 In-house 55-276 (284) alignment 
Range on Protein: 18-234
Range on HMM: 55-276/284.0
SPASYINGNWMDGF-----SQSREYIVTQGPLPNTIDAFWRMVWEFKVCQIVMITNLKEKGRVKCEKYWPFEGEQLKIGDLILLCEEVKLHAAFQVAQLR
.  .||| ...||.      .....|.||||||||.. ||||||| .|  |||.|.| |.||.||..||| ||| |..||..  . ... .  . |  |.
edsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweqnvrvIVmltelvengrekcaqYwplegevltygdftvtllseevkddytvrtle

VVHRH-TGVAHTVHHLWFQDWPDHGVPDTTEAVIDLLLTSRELRTRalasREQVAPIAVHCSAGIGRSGVFVGCDILLQQAESFG---QVDALGALCHMR
... . ||  .||.|... .|||||||...| ....| . |||...    ...  ||.||||||.||.|.|. .|.||.| |  |    ||.|.|....|
ltnlgytgesrtvthfhytswpdhgvppspedlleflrlvrellen....lpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlr

RARGGCVQTPHQWLYMLLVAHDYLAK
. | |.|||. | ..   ....|| .
eqRpgmvqtleqyrfvyealleylkl
0040438 (Phosphotyrosine protein) phosphatases II 19-234 5.5e-73 241.3 In-house 70-278 (317) alignment 
Range on Protein: 19-234
Range on HMM: 70-278/317.0
PASYINGNWMDGFSQSREYIVTQGPLPNTIDAFWRMVWEFKVCQIVMITNLKEKGRVKCEKYWPFeGEQLKIGDLILLCEEVKLHAAFQVAQLRVVHRHT
. .||| ...||....|..|.||||||||.. ||||||| .|. |||.|.|.|.||.||..|||  || |..||..  . ... .| ... .|.|..  .
dsdYInAsyvdgpnlkrkfIatqgPlpntvedFwrmvweqgvtvivmLteleelgrekcaqYwpl.getltygdftvtllseeelagitlrtlevedlgd

GVAHTVHHLWFQDWPDHGVPDTTEAVIDLLLTSRELRTralasrEQVAPIAVHCSAGIGRSGVFVGCDILLQQAESFGQVDALGALCHMRRARGGCVQTP
.  .||.|... .|||||||.... ..|.|   || .       ..  |..||||||.||.|.|......|.| |  |.||.  |....|..|.|.||||
sesrtvthfhytgWpdhgvppspdllldfleavreale......dpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtp

HQWLYMLLVAHDYLAK
 |. ..  ....|| .
eqyrflydalleylkr
0051299 (Phosphotyrosine protein) phosphatases II 18-232 8.8e-73 240.6 In-house 75-286 (288) alignment 
Range on Protein: 18-232
Range on HMM: 75-286/288.0
SPASYINGNWMDGFSQSREYIVTQGPLPNTIDAFWRMVWEFKVCQIVMITNLKEKGRVKCEKYWPFeGEQLKIGDLILLCEEVKLHAAFQVAQLRVVHR-
.. .||| ...||. ..|..|.||||||||.. ||||||| .|  |||.|.| |.||.||..|||  |. |..||.   . ... .. . | .|.|..  
egsdYinAsyidgynlkrkfIatqgPlpntvedFWrmvweqnvrvIvmltklvelgrekcaqYwpl.ggsltygditvtllseevlddytvrtlevtnld

---HTGVAHTVHHLWFQDWPDHGVPDTTEAVIDLLLTSRELRTralasrEQVAPIAVHCSAGIGRSGVFVGCDILLQQAESFGQVDALGALCHMRRARGG
    .|  .||.|... .||||||||..|...|.|   |. .        .  |..||||||.||.|.|. .|.||.| |  | ||.|.|....|. | |
lldgdgesrtvthfhytnwpdhgvpdspellldflrlvrkala......sgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpg

CVQTPHQWLYMLLVAHDYL
.|||| | ..   ....||
mvqtpeqyrfvyealleyl
0047943 (Phosphotyrosine protein) phosphatases II 15-232 3.7e-72 238.4 In-house 57-272 (273) alignment 
Range on Protein: 15-232
Range on HMM: 57-272/273.0
LHPSPASYINGNWMDGFSQSREYIVTQGPLPNTIDAFWRMVWEFKVCQIVMITNLKEKGRVKCEKYWPFEGE--QLKIGDLILLCEEVKLHAAFQVAQLR
|.... .||| ...||. ..|..|.||||||||.. ||||||| .|  |||.|.| |.||.||..||| ||.   |. |...  . ... .. . | .|.
lgdggsdyinAsyvdgynlkrkfiatqgPlpntvedfwrmvweqnvrviVmLtelvelgrekcaqYwpleggelsltygkftvtllseetkddytvrtle

VVHRHTGVAHTVHHLWFQDWPDHGVPDTTEAVIDLLLTSRELRTRALASreqvAPIAVHCSAGIGRSGVFVGCDILLQQAESFGQVDALGALCHMRRARG
... .||  .||.|... .|||||||...| .....   |. .  .  .     |..||||||.||.|.|. .|.||.| |  |.||.| |....|. | 
ltnlgtgesrtvthfhytgwpdhgvppslesllefielvrkalealpsn....gpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRp

GCVQTPHQWLYMLLVAHDYL
|.|||| |....  ....||
gmvqtpeqyrflyealleyl
0045450 (Phosphotyrosine protein) phosphatases II 18-232 1.6e-70 233.6 In-house 82-304 (307) alignment 
Range on Protein: 18-232
Range on HMM: 82-304/307.0
SPASYINGNWM--------DGFSQSREYIVTQGPLPNTIDAFWRMVWEFKVCQIVMITNLKEKGRVKCEKYWPFEGEQLKIGDLILLCEEVKLHAAFQVA
.. .|||....        ||. ..|..|.||||||.|.. ||||.|| .|  |||.|.|.|.||.|| .||| |||.| .|..   . ... .. ..| 
edsdYiNAsyvrvpllllldgydlkrkfIatqgPlpetvedFwrmlweqgvtvivmltelvelgrekcaqywPdegeeltygnftvtllseehldgytvr

QLRVVHR-HTGVAHTVHHLWFQDWPDHGVPDTTEAVIDLLLTSRELRTRAlaS-ReqvAPIAVHCSAGIGRSGVFVGCDILLQQAESFGQ---VDALGAL
.|.| .   ||  .||.|... .|||||||...| ..|..   |. . .   .      |..||||||.||.|.|......|.| |. |    ||.| |.
tlevtdldgtgesrtvthfhytgwpdhgvppsfeelldfieevrkaleel..pkg...gpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleav

CHMRRARGGCVQTPHQWLYMLLVAHDYL
...|. |.|.||.|.|. .   .....|
kllreqRpgavqnpeqyrflyeallell
subfamily_PTPRD_pd Subfamily PTPRD 21-234 1.9e-70 233.1 In-house 77-283 (564) alignment 
Range on Protein: 21-234
Range on HMM: 77-283/564.0
SYINGNWMDGFSQSREYIVTQGPLPNTIDAFWRMVWEFKVCQIVMITNLKEKGRVKCEKYWPFEGeQLKIGDLILLCEEVKLHAAFQVAQLRVVHRHTGV
 ||| ...||. ....|| |||||..||. ||||||| ... |||.|.|.|||.|||.|||| .| . ..|.|.   || .  | ... .... . ..  
DYINAsfidgyrkrkayIAtqgPlaetiedFWRmvweqnsstiVmltkleEkgkvkchkYWPekg.tetygeltVtleeeeeladyeirtfklkkkksse

AHTVHHLWFQDWPDHGVPDTTEAVIDLLLTSRELRTralasrEQVAPIAVHCSAGIGRSGVFVGCDILLQQAESFGQVDALGALCHMRRARGGCVQTPHQ
...|..  | .|||||||.......||. ..|.|..      ..  || ||||||.||.|.|.  |..|..... ..||  . . ..|. |   |||..|
sreVrqFhFtsWPdhgvpesatslLdlirkvralne......pdagPivVhCSaGVGRTGtfividamlerikeektvDiyqyvkalrkqRnamVqteeQ

WLYMLLVAHDYLAK
. ..  .  ..||.
YiFiheailealac
0039614 (Phosphotyrosine protein) phosphatases II 18-233 4.7e-70 231.7 In-house 83-290 (297) alignment 
Range on Protein: 18-233
Range on HMM: 83-290/297.0
SPASYINGNWMDGFSQ-SREYIVTQGPLPNTIDAFWRMVWEFKVCQIVMITNLKEKGRvKCEKYWPFEGEqlKIGDLILLCEEVKLHAAFQVAQLRVVHr
 . .||| ...||... .|..|.||||||.|.. ||||||| .|  |||.|.|.|.|| ||..||| ||.  . ||.   . .|. .. . | .|.|.. 
ldsdYinAsyvdgydlltrkfIatqgPlpetvedFwrmvweqgvtvivmLtklvelgr.kcaqywpeegg..tygdftvtllkvehldgytvrtlevtn.

hTGVAHTVHHLWFQDWPDHGVPDTTEAVIDLLLTSRELRTRAlasrEQVAPIAVHCSAGIGRSGVFVGCDILLQQAESFGQVDALGALCHMRRARGGCVQ
 .|  .||.|... .|||||||...| ....|   || . ..    ..  |..||||||.||.|.|......|.| |. |.||.| |....|..|.|.||
.ngesrtvthfqytgwpdhgvppslellleflelvrealael....pkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavq

TPHQWLYMLLVAHDYLA
||.|. .   .....| 
tpsqyrflydallellk
0043336 (Phosphotyrosine protein) phosphatases II 20-231 3.8e-69 228.6 In-house 73-276 (278) alignment 
Range on Protein: 20-231
Range on HMM: 73-276/278.0
ASYINGNWMDGFSQSREYIVTQGPLPNTIDAFWRMVWEFKVCQIVMITNLKEKGRVKCEKYWPfeGEQLKIGDLILLCEEVKLHAAFQVAQLRVVHRHTG
 .||| ...||....|..|.||||||.|.. ||||||| .|  |||.|.|.|.||||| .|||  |. |..||.   . ... .. . | .|.|... .|
sdYinAsyvdgynvprkfiatqgPlpetvedFwrmvwelgvttivmLtelvelgrvkcaqYwp..ggsltygdftvtllkeehlddytvrtlevtnlgdg

VAHTVHHLWFQDWPDHGVPDTTEAVIDLLLTSRELRTralasrEQVAPIAVHCSAGIGRSGVFVGCDILLQQAESFGQVDALGALCHMRRARGGCVQTPH
  .||.|... .|||||||.... ..|.| . || .        .  |..||||||.||.|.|.....||.|.|. | ||.. |....|. |.|.|||| 
esrtvthyhylgwpdhgvpeslsllldflkavreale......dsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtps

QWLYMLLVAHDY
|. .   ....|
qyrflyealley
0040439 (Phosphotyrosine protein) phosphatases II 19-232 7.3e-67 220.9 In-house 38-246 (249) alignment 
Range on Protein: 19-232
Range on HMM: 38-246/249.0
PASYINGNWMDGFSQSREYIVTQGPLPNTIDAFWRMVWEFKVCQIVMITNLKEKGRVKCEKYWPFeGEQLKIGDLILLCEEVKLHAAFQVAQLRVVHRHT
. .||| ...||. ..|..|.||||||.|...||||.|| ..  |||.|.|.|.||.||..|||  |. |..||.   . .|. .. . | .|....  .
lsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywpl.ggsleygdftvtllsvevkddytvrtleltnlyd

GVAHTVHHLWFQDWPDHGVPDTTEAVIDLLLTSRELRTRAlasrEQVAPIAVHCSAGIGRSGVFVGCDILLQQAESFGQVDALGALCHMRRARGGCVQTP
|  .||.|... ||||||||...| ..|..   |. ....    ..  |..||||||.||.|.|......|.| |  ..||.. |....|..|.|.||.|
gesrtvlhiqytdwpdhgvppsfedlldfieavrkaleel....pkggpvlVHCsaGvgRtGtfiaaylmleqlekelgvdleeavkllrsqRpgavqnp

HQWLYMLLVAHDYL
.|. . . .....|
eqyrflyeallell
subfamily_PTPRB_pd Subfamily PTPRB 20-227 2.1e-66 218.9 In-house 79-280 (293) alignment 
Range on Protein: 20-227
Range on HMM: 79-280/293.0
ASYINGNWMDGFSQSREYIVTQGPLPNTIDAFWRMVWEFKVCQIVMITNLKEKGRVKCEKYWPFEGEQLKIGDLILLCEEVKLHAAFQVAQLRVVHrhTG
. ||| |...|... ||.|.||||||.|.| ||||||| |.  |||.|.| |||.||||.||| . |.   ||. .   . .    . . .|.. .  . 
sDYinanyipgynsprefiatqGPlpetvddfWrmvwekkssiivmltqlvekgkvkCeeYWPadeepvlyGdikvtlvaeeeledwvirelkiek..ek

VAHTVHHLWFQDWPDHGVPDTTEAVIDLLltsRELRtRALASREQVAPIAVHCSAGIGRSGVFVGCDILLQQAESFGQVDALGALCHMRRARGGCVQTPH
  ..|... |. |||||||..|....|..   |..| .|. . .. .|| ||||||.||.|.|.  | |||. |.   || .| ....|. |   ||| .
eerkvrqyhftsWpdhgvPektktlldfv...rtvr.eaiektaskrPivvhCsaGvGRtGtfialdrllqaieeedyvdifgivaelReeRnllvqtek

QWLYMLLV
|....  .
qYifihqc
DSPc_SM00195 18-232 2.2e-65 216.0 In-house 52-262 (263) alignment 
Range on Protein: 18-232
Range on HMM: 52-262/263.0
SPASYINGNWMDGFSQSREYIVTQGPLPNTIDAFWRMVWEFKVCQIVMITNLKEKGRVKCEKYWPFE-GEQLKIGDLILLCEEVKLHA-AFQVAQLRVVH
.. .||| |...| .....||.||||||.|.. ||||||| || .|||.|. .|.|. ||..||| | |.. ..|.. . . ||. .   ... .|.. .
egsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlteeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltk

RHTGVAHTVHHLWFQDWPDHGVPDTTEAVIDLLLTSRELRTRAlasreqVAPIAVHCSAGIGRSGVFVGCDILLQQAESFGQVDALGALCHMRRARGGCV
  .  ...|.......||||||||.|. |..|| . .. . .        .|| ||||||.||.|.||  ||.|.. |.  .||    ....|  | |.|
egkeetrkvtqyqyknWpdhgvpdstksvlellravkksksts......sgpivVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmv

QTPHQWLYMLLVAHDYL
||  |.|..  .. .|.
qtleqYlfiyeaileyi
PTPc_SM00194 18-232 2.2e-65 216.0 In-house 52-262 (263) alignment 
Range on Protein: 18-232
Range on HMM: 52-262/263.0
SPASYINGNWMDGFSQSREYIVTQGPLPNTIDAFWRMVWEFKVCQIVMITNLKEKGRVKCEKYWPFE-GEQLKIGDLILLCEEVKLHA-AFQVAQLRVVH
.. .||| |...| .....||.||||||.|.. ||||||| || .|||.|. .|.|. ||..||| | |.. ..|.. . . ||. .   ... .|.. .
egsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlteeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltk

RHTGVAHTVHHLWFQDWPDHGVPDTTEAVIDLLLTSRELRTRAlasreqVAPIAVHCSAGIGRSGVFVGCDILLQQAESFGQVDALGALCHMRRARGGCV
  .  ...|.......||||||||.|. |..|| . .. . .        .|| ||||||.||.|.||  ||.|.. |.  .||    ....|  | |.|
egkeetrkvtqyqyknWpdhgvpdstksvlellravkksksts......sgpivVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmv

QTPHQWLYMLLVAHDYL
||  |.|..  .. .|.
qtleqYlfiyeaileyi
0042113 (Phosphotyrosine protein) phosphatases II 20-232 3.1e-64 212.0 In-house 37-243 (245) alignment 
Range on Protein: 20-232
Range on HMM: 37-243/245.0
ASYINGNWMDGFSQSREYIVTQGPLPNTIDAFWRMVWEFKVCQIVMITNLKEKGRVKCEKYWPFeGEQLKIGDLILLCEEVKLHAAFQVAQLRVVHRHTG
 .||| ...||. ... .|.||||||.|...||||.|| ..  |||.|.. |.|||||..|||  || |..||..  . ... .. . | .|.|..  ..
sdyinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywpl.gesltygdftvtllseehlddytvrtlevtnlgdd

VAHTVHHLWFQDWPDHGVPDTTEAVIDLLLTSRELRTRalasrEQVAPIAVHCSAGIGRSGVFVGCDILLQQAESFGQVDALGALCHMRRARGGCVQTPH
  ..|.|... .||||||||..| ..|.|   |. . .      .  |..||||||.||.|.|......|.|.|. . |..  |. ..|. |.|.||||.
esrevihyhylpwpdhgvpdllellldflefvrkalae.....dsngpvlVHCsaGvgRtGtfiaaylmleqlekelgvsleeavkelrsqRpgavqtps

QWLYMLLVAHDYL
|. ..  .....|
qyrflyeallell
0045098 (Phosphotyrosine protein) phosphatases II 21-232 1.1e-63 210.5 In-house 52-272 (278) alignment 
Range on Protein: 21-232
Range on HMM: 52-272/278.0
SYINGNWMDGFsqSREYIVTQGPLPNTIDAFWRMVWEFKVCQIVMITNLKEKGRVKCEKYWPfEGEQLKIGDLILLCEEVKLHAAFQVAQLRVVHR----
 ||| ...||.  ....|.||||||.|...||||.|| ..  |||.|.|.|.||.||..||| ||. | .||. . ..... .  . .  |.|..     
dYINAsyidgy..pkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrekcaqywp.eggsltygdftvtllseevlddytlrtllvtnltver

HTGVAHTVHHLWFQDWPDHGVPDTT--EAVIDLLLTSRELRTRALAS-------REQVAPIAVHCSAGIGRSGVFVGCDILLQQAeSfGQVDALGALCHM
...  ..|.||..  |||||||...    ...||   || . ...          ..  |..||||||.||.|..|.....|..    |.||.| |....
edlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsggpvlVHCsaGvgRtGtlvaaylmlell.e.ggvdlleavkel

RRARGG-CVQTPHQWLYMLLVAHDYL
|. |.| .||...|. ..  .. ..|
rsqRpglavqnleqyrflyefllell
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 20-234 1.6e-62 206.1 In-house 69-278 (281) alignment 
Range on Protein: 20-234
Range on HMM: 69-278/281.0
ASYINGNWMDGFSQSREYIVTQGPLPNTIDAFWRMVWEFKVCQIVMITNLKEKGRVKCEKYWPFEGEQLKIGDLILLCEEVKLHAAFQVAQLRVvHRHTG
. ||| |...|... .|||.||||.|....|||.|||| ||..|||.|.  |.|..|| .||| . ..||.||...  .. . .| .   .... .|..|
tDYinanfvpgykgekeyiatqgPvPaslvafWqmvweqkvsaivmvtreieagklkChrYWPddnselkygdvtvkstaeeekatyierkfkl.eresg

VAHTVHHLWFQDWPDHGVPDTTEAVIDLlltSRELRTraLASREQVAPIAVHCSAGIGRSGVFVGCDILLQQAES-FGQVDALGALCHMRRARGGCVQTP
 . .|..| .. |||||||.||.....     .|..   | .... ||. .|||||.||.|.... | |....|.   ..|    . ..|..|   ||| 
etreveqlaytaWPdhGvPattkellef...rkevlk..ltekktkaplvihCsaGvGrtGtyialDrlvkaveaeleeldvkavvaelrkernlmvqtv

HQWLYMLLVAHDYLAK
 |. .. ..  |.| |
vqyefvykavldaldk
Y_phosphatase Protein-tyrosine phosphatase 16-226 9.9e-62 203.8 Pfam-A 23-231 (235) alignment 
Range on Protein: 16-226
Range on HMM: 23-231/235.0
HPSPASYINGNWMDGFSQSREYIVTQGPLPNTIDAFWRMVWEFKVCQIVMITNLKEKGRVKCEKYWP-FEGEQLKIGDLILLCE-EVK-LHAAFQVAQLR
...|  ||| |...|.......|.|||||..||. ||||||. ||  |||.|.|.||||.||..|||  |.|.|. ||. . .. ..|  ...... .|.
segpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeesltygdikvelkekekedekeytlrkle

VVHRHTG-VAHTVHHLWFQDWPDHGVPDTTEAVIDLLLTSRELRtralasREQVAPIAVHCSAGIGRSGVFVGCDILLQQAESFGQVDALGALCHMRRAR
. .. .    ..|..|....|||||||.......||.   .. .      ... .|. ||||||.||.|.||  ||||.|.|. ..|| | .....|. |
lkkkkeesekrevkqlhytnWpdhgvpespkslldlirkveksk......eaksgpvvVhCsaGvgRtgtfvaldilleqleaeeevdvlqivkelRkqR

GGCVQTPHQWLYMLL
 |.||. .|  ..  
pgmvqsleqYiflyk
Y_phosphatase Protein-tyrosine phosphatase 16-226 9.9e-62 203.8 In-house 23-231 (235) alignment 
Range on Protein: 16-226
Range on HMM: 23-231/235.0
HPSPASYINGNWMDGFSQSREYIVTQGPLPNTIDAFWRMVWEFKVCQIVMITNLKEKGRVKCEKYWP-FEGEQLKIGDLILLCE-EVK-LHAAFQVAQLR
...|  ||| |...|.......|.|||||..||. ||||||. ||  |||.|.|.||||.||..|||  |.|.|. ||. . .. ..|  ...... .|.
segpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeesltygdikvelkekekedekeytlrkle

VVHRHTG-VAHTVHHLWFQDWPDHGVPDTTEAVIDLLLTSRELRtralasREQVAPIAVHCSAGIGRSGVFVGCDILLQQAESFGQVDALGALCHMRRAR
. .. .    ..|..|....|||||||.......||.   .. .      ... .|. ||||||.||.|.||  ||||.|.|. ..|| | .....|. |
lkkkkeesekrevkqlhytnWpdhgvpespkslldlirkveksk......eaksgpvvVhCsaGvgRtgtfvaldilleqleaeeevdvlqivkelRkqR

GGCVQTPHQWLYMLL
 |.||. .|  ..  
pgmvqsleqYiflyk
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 20-235 4e-60 198.2 In-house 57-271 (274) alignment 
Range on Protein: 20-235
Range on HMM: 57-271/274.0
ASYINGNWMDGFSQ-SREYIVTQGPLPNTIDAFWRMVWEFKVCQIVMITNLKEKGRVKCEKYWPFEGEQ---LKIGDLILLCEEVKLHAAFQVAQLRVVH
.|||| |.. |... |. |. ||||||||.. ||||... .|  |||.|.|||. . ||..|.| . .     . ||. .  |... .  ..| .| . .
ssyinanyikGydeeskayvatqGPlpntvadfWrmiyqeevqvivmltklkeaneqkCavyfPdaedyeiserygdveikvekiverndysvrklvlky

RHTgvAHTVHHLWFQDWPDHGVPDTTEAVIDLLLTSRELRTralASREQVAPIAVHCSAGIGRSGVFVGCDILLQQAESFGQVDALGALCHMRRARGGCV
 .    ..|.| |. ||||| .|| .....||.|  .| |.   .. ...||. ||||||||| |.|.. .| ..| .  . || |.  |..|  ||| |
ler..ersvkhywytdWPdhksPddantlldlvleveesre...eenaklapvvvhCsaGiGrtGcfiaisiavrqlreeivvdvlkivcnlrldrGGmv

QTPHQWLYMLLVAHDYLAKV
|| .|. ..  .   || ..
qtseqyelihralclylkrl
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 20-234 4.9e-59 195.0 In-house 74-282 (318) alignment 
Range on Protein: 20-234
Range on HMM: 74-282/318.0
ASYINGNWMDGFSQSREYIVTQGPLPNTIDAFWRMVWEFKVCQIVMITNLKEKGRVKCEKYWPFEGEQlKIGDLILLCEEVKLHAAFQVAQLRVVHRHTG
. ||| |..||. ....|| .|.|||.||. ||||||| . . |||.|...|.|..|...||| .| . ..|.|    .| .  . . . ...| .... 
sDyinanyidGyrrkkayiaaqaPlpetieDfWrmvWeqnsavivmltqeeergkakvhryWPskgsr.sygklvvelkeevelsdyvlrefkvtrteee

VAHTVHHLWFQDWPDHGVPDTTEAVIDLLLTSRELRtralaSREQVAPIAVHCSAGIGRSGVFVGCDILLQQAESFGQVDALGALCHMRRARGGCVQTPH
   .|.   . .|||.|||. .  ..||. ....        .... ||.||||||.|| |||.  ||||....  . || ..   ..|. |   ||| .
esrqvrqyhytsWpdegvpesgaslldlvrqvskaq.....qksgagpivvhCsaGvGrtGvfiavdillerikaealvDvfqtvkqlreqrnlmvqted

QWLYMLLVAHDYLAK
|. ..  |  ..|| 
qyefiydvllealas
subfamily_PTPN9_pd Subfamily PTPN9 19-230 3e-58 192.2 In-house 69-288 (297) alignment 
Range on Protein: 19-230
Range on HMM: 69-288/297.0
PASYINGNWMDGFSQSREYIVTQGPLPNTIDAFWRMVWEFKVCQIVMITNLKEKGRVKCEKYWP-FEGEQLKIGDLILLCEEVKLHAAFQVAQLRVVHRH
 . ||| |..||. | . .| |||||..|.. ||||||| .|  |||.| . |.||.|| .|||  |... . ||| .   ||. . ...|..| . . .
asdyinanfvdGykqkkafiatqGplkktvsdfWrmvWeqevlvivmttrvvergrlkcgqyWpleeessaefgdlsvsnveveeeedykvrvleiknvk

TGVAHTVHHLWFQDWPDHGVPDTTEAVIDLLLTSRELRTRA---LAS----REQVAPIAVHCSAGIGRSGVFVGCDILLQQAESFGQVDALGALCHMRRA
|.   .| |  |  |||.|||.......|.| . || .. |   |..    . .  || |||||||||.| |.  || |.. |. |.||   .. ..|  
teesrkvthfqflsWPdyGvPssaaslldvlekvrekqalavkelgdewkghpsgPPivvhcsaGiGrtGtfitldiclsrleevgtvdvvetvkllrtq

RGGCVQTPHQWLYMLLVAHD
|   .|||.|. .  |   .
rafsiqtpeqyefcylavle
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 19-233 3.3e-58 191.8 In-house 46-265 (270) alignment 
Range on Protein: 19-233
Range on HMM: 46-265/270.0
P-ASYINGNWMDGFSQ-SREYIVTQGPLPNTIDAFWRMVWEFKVCQIVMITNLKEKGRVKCEKYWPFEGEQ---LKIGDLILLCEEVKLHAAFQVAQLRV
. . ||| |.. ||.. ...|| ..||||.|. .||||.|| ||  |||.|.|.|||| |||.||| | ..   |. |..  | .. . .  . . .||.
sataYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkgrkkCerYWpaepkekvkledgkikvlalseekeegyiltrlrl

VhrHTGVAHTVHHLWFQDWPDHGVPDTTE------AVIDLLLTSRELRTRalaSrEQVAPIAVHCSAGIGRSGVFVGCDILLQQAESFGQVDALGALCHM
   ..|  . . | |...||||||| ...       .. .| . |. ...     ..  |. ||||||.||.|...  || ..  |. ..|| |  . ..
e..ekgeerrlvHfwyntWpdhgvpreedsslstdqllkmlravrrseke...l.dkaePllvHcsaGvgRtGtlialDiavrlLeetkkvdvlaiieel

RRARGGCVQTPHQWLYMLLVAHDYLA
|. |  .||.|.|. ..  .   |  
RkdRmalvqhpeqyeflykavveyae
0037934 (Phosphotyrosine protein) phosphatases II 18-231 2.4e-57 189.6 In-house 30-241 (243) alignment 
Range on Protein: 18-231
Range on HMM: 30-241/243.0
SPASYINGNWMDGFsqsREYIVTQGPLPNTIDA----FWRMVWEFKVCQIVMITNLKEKGRVKCEKYWPfeGEQlKIGDLILLCEEVKLHAAFQVAQLRV
.. .|||.|.....   . .|.||||||.|..     ||||.|| ..  |||.|.|.|.||.||..|||  ||.  .||..  . ... .. . |  |..
egsdyinanliyvt...prliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywp..gev.tygdftvtllseehlddytvrtlll

VHRH-TGVAHTVHHLWFQDWPDHGVPDTTEAVIDLLLTSRELRTR-----ALASReqvAPIAVHCSAGIGRSGVFVGCDILLQQAesfgQVDALGALCHM
..   ... ..|.|...  ||||||||..| ..|.|   ||   .     || |     |..||||||.||.|... ....|..     .||.. |....
enldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsg...gpvlVHCsaGvgRtGtliaaylmllll....gvdleeavkll

RRARGG-CVQTPHQWLYMLLVAHDY
|. |.| .||||.|. .   ... .
reqRpgkavqtpsqyrflyeallel
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 20-227 6.9e-56 184.6 In-house 76-278 (319) alignment 
Range on Protein: 20-227
Range on HMM: 76-278/319.0
ASYINGNWMDGFSQSREYIVTQGPLPNTIDAFWRMVWEFKVCQIVMITNLKEKGRVKCEKYWPfEGEQLKIGDLILLCEEVKLHAAFQVAQLRVVHRHTG
. ||| ...||. . ...| ||.|| |||. ||||||| ..  .||.|.|.||..||..|||| | .  . | ||.  || .  . . . .| . .. . 
sdyinasfidgyqerekfiatqaPlentiedfWrmvWeeessivvmltklveklkvklkkywp.eenfeeyGrlivtleeeeeledyiirklklnkksse

V-AHTVHHLWFQDWPDHGVPDTTEAVIDLLltsRELRtrALASREQVAPIAVHCSAGIGRSGVFVGCDILLQQAESFGQVDALGALCHMRRARGGCVQTP
| . .| |  ...||||.||... ...|||   ...|     ...|  || ||||||.|| | |.  |. |.. .  | .|      ..|  |   ||.|
vetRevkhfqyteWpdhdvPekatslldll...krir..ksrektqsgPivvhCsaGvGRtGtfivldamlervkeegvlDvfstvsrlRtqRnimvqrp

HQWLYMLLV
.|. ..  .
eqYkfiyea
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 19-228 9.7e-56 184.1 In-house 71-279 (305) alignment 
Range on Protein: 19-228
Range on HMM: 71-279/305.0
P--ASYINGNWMDGFSQSREYIVTQGPLPNTIDAFWRMVWEFKVCQIVMITNLKEKGRVKCEKYWPF-EGEQLKIGDLILLCEEVKLHAAFQVAQLRVVH
   . ||| ...||.... .|||.||||.||.. |||...|.|| .|||.|.|.| |. ||..|||  ..|. ..|....  .. |  . .   .|..  
lddsdyinasyvdgykrkkkyivaqgPlkntvadfWrliveekvstivmltklveggkdkCrqYWpesktekkefgefsvelksektasdyieRklkisi

-RHTGVAHTVHHLWFQDWPDHGVPDTTEAVIDLLltsRELRTRalASREQVAPIAVHCSAGIGRSGVFVGCDILLQQAESFGQVDALGALCHMRRARGGC
 ..    .|| .. . ||||||||... ....|.   .... .   ....  |. ||||||.||.|||.  || |....  ..||  . | ..|. | . 
ededkesrtvlqyqltdWPdhGvpqfatsllsli...krvqkd..qkkdkgvpllVhCsagvgRtGvfiavdialerlkkEevvdvfevlkqlRskrmkm

VQTPHQWLYMLLVA
|||  |. ..  . 
vqtldqYvflhdal
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 20-225 1.5e-55 183.3 In-house 75-272 (288) alignment 
Range on Protein: 20-225
Range on HMM: 75-272/288.0
ASYINGNWMDGFSQSREYIVTQGPLPNTIDAFWRMVWEFKVCQIVMITNLKEKGRVKCEKYWPFEGEQLKIGDLILLCEEVKLHAAFQVAQLRVVhrHTG
| ||| ...||  ....|| |||||..|.. ||..|.| |.  |||.|.| |.|. |||.||| .... . |.. .   |.|    | . .| ..  ...
aDYinasyidgekkkkkyiatqgPladtvndfWelvyenktstivmltelveggktkCeeYWPdadkpknyGsvtvtlveskeledfvlrkllle..kkk

VAHTVHHLWFQDWPDHGVPDTTEAVIDLLltsrelRTRALASREQVAPIAVHCSAGIGRSGVFVGCDILLQQAESFGQVDALGALCHMRRARGGCVQTPH
   ..... .. |||||||. .. ...||      |.   |. ... || ||||||.||.|.|.  | |... |.  ..| .|.....|. |   ||| .
teleitqyqylaWpdhgvPeskapllell......rqvkvanqadtgpiivhCsaGvGrtgtFialdalidaveeedyiDvagtvaklRkqRallvqtlk

QWLYML
|. .. 
qYefiy
subfamily_PTPRG_pd Subfamily PTPRG 21-225 5.3e-54 178.4 In-house 77-280 (563) alignment 
Range on Protein: 21-225
Range on HMM: 77-280/563.0
SYINGNWMDGFSQSREYIVTQGPLPNTIDAFWRMVWEFKVCQIVMITNLKEKGRVKCEKYWPFeGEQLKIGDLILLCEEVKLHAAFQVAQLRVVHRH---
 ||| |..||. .|...|.|||||..|.| ||||.|| .|  |||||||.|.|| ||. |||   | ...| | .  .| . .|  .| .| . ...   
DYinAnyidGyqkskafiatqgplkdtfddFWrmiWeqnvaiivmitnlvergrrkcdvYWPk.desetygalqvtlieeevlalytvrtlviknlklkk

TG---VAHTVHHLWFQDWPDHGVPDTTEAVIDLLLTSrelrtrALASREQVAPIAVHCSAGIGRSGVFVGCDILLQQAESFGQVDALGALCHMRRARGGC
.      ..| .  . .|||||||. .  |.     |      . | .... || ||||||.||.|...  | ||.| ..  .|. .| | |.|  |   
kkqcdteklvrqyhytkWPdhgvPehslpvLifvkks......saankaeaGPivvHcsaGvgrtGtyivldtllkqiqqenavnvfgflkhiraqRnfl

VQTPHQWLYML
|||  |.... 
vqteEqYiflh
subfamily_PTPN3_pd Subfamily PTPN3 14-224 1e-53 177.1 In-house 59-267 (280) alignment 
Range on Protein: 14-224
Range on HMM: 59-267/280.0
TLHPSPASYINGNWM----DGFSQSREYIVTQGPLPNTIDAFWRMVWEFKVCQIVMITNLKEKGRVKCEKYWPFEGEQLKIGDLILLCEEVKLHAAFQVA
.|. |.. ||| |..    .. ...  ||.|||||..|   ||.|||| |.  |||.|.| |.||||| .||| ....|. |.. . ||. . . .. . 
klkesetdyinanyvnmeipstglvnryiatqGPlaktatdfWqmvweqksslivmlttlverGrvkChqyWPetedeleygefsvkcekedetksyvlr

QLRVVHRHTGVAHTVHHLWFQDWPDHGVPDTTEAVIDLLLTSRELRtralasREQVAPIAVHCSAGIGRSGVFVGCDILLQQAESFGQVDALGALCHMRR
.| . ...|   .....| . .|||||||| .. ..... . |.||      . .  |. |||||||||.||..  .. |.  |.  .|  |  . .|| 
elvlkdketkeerkilqlqylaWpdhgvPddsadflefvervrklr......sgkeePvvvhCsaGigrtGvlilletalalieaaepvypldivrtmrd

ARGGCVQTPHQWLYM
 |.  |||..|. ..
qramlvqtasqykfv
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 20-233 2.9e-52 172.8 In-house 84-291 (298) alignment 
Range on Protein: 20-233
Range on HMM: 84-291/298.0
ASYINGNWMDGFSQSREYIVTQGPLPNTIDAFWRMVWEFKVCQIVMITNLKEKGRVKCEKYWPFEGEQlKIGDLILLCEEVKLHAAFQVAQLRVVHRHTG
. |||  ........  .|.||.||..|.  |||||.| ..  |||.|||.|....|..|||| ||.. . |.. .   . . .| . | .| | .... 
sdYiNAsflhaykgrnafiatqaPltetvedFWrmvteedigtiVmltnleeldktkyhkywPdegke.tygeitvsllskeefadlivrklkvskkkee

VAHTVHHLWFQDWPDHGVPDTTEAVIDLLLTSRElrtraLASREQVAPIAVHCSAGIGRSGVFVGCDILLQQAESFGQVDALGALCHMRRARGGCVQTPH
  ..|..| |  |||.||| ....|.|||   |        ..   .|. |.||||.|||| |.  | .|....    || . ..  .|. | | ||| .
kerevrqlhftsWpdkgvpenatsvldllrkvra.....sqqqagnkpvivqCsaGvgRsGtfiaidsvlervkkeqvvDvfqvvkvlRkkrpgavqtee

QWLYMLLVAHDYLA
|. ..  .  ..|.
qYvfiyeavleald
subfamily_PTPN12_pd Subfamily PTPN12 20-227 4.9e-51 168.3 In-house 68-272 (290) alignment 
Range on Protein: 20-227
Range on HMM: 68-272/290.0
ASYINGNWMDGFSQSREYIVTQGPLPNTIDAFWRMVWEFKVCQIVMITNLKEKGRVKCEKYWPFEG-EQLKIGDLILLCEEVKL-HAAFQVAQLRVVHRh
 .|||.|.. | ... ||| .|||||.|.| ||||.||..|  .||. .. | |. |||.||| || |.|..|.. . .|| |  .  | . .|.| .. 
sdYinanfikgvegkleyiaaqgPLpktlddfWrmiweknveivvmaCrevelgkkkCerYWpeegeeelefgefevtleeekavdddflirtLkveaq.

tGVAHTVHHLWFQDWPDHGVPDTTEAVIDLLLTSRELRTralasrEQVAPIAVHCSAGIGRSGVFVGCDIL---LQQAESFGQVDALGALCHMRRARGGC
 .  ..|. . ...||||||| ... ...|. . |||..      .. ||..||||||.|| |. .  |.    |..     ..|    . ..|. |   
.kesrkvyqfhYtaWPDhgvPssaksllelielvrelqe......sedaPlvvhCsaGvGrtGtiiaidyvrellkaekipeeldvfdlvlelrkqraal

VQTPHQWLYMLLV
|||  |. ..   
vqtkeqyelvyka
subfamily_PTPN13_pd Subfamily PTPN13 21-232 6.3e-51 168.2 In-house 61-269 (273) alignment 
Range on Protein: 21-232
Range on HMM: 61-269/273.0
SYINGNWMDGF--SQSREYIVTQGPLPNTIDAFWRMVWEFKVCQIVMITNLKEKGRVKCEKYWPFE-GEQLKIGD-LILLCEEVKLHAAFQVAQLRVVHR
.||| ...      .  |||..|||||.|.. ||.|||| |.  |.|.|. ||||.|||..||| . ...||. . | .  ..|. . .|.| .| | . 
gyinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweqkaeviamvtlekekgkvkchrywPesknkklkvsnrlevellkvqkldgfvvralavkds

HTGVAHTVHHLWFQDWPDHGVPDTTEAVIDLLLTSRELRTralasreQVAPIAVHCSAGIGRSGVFVGCDILLQQAESFGQVDALGALCHMRRARGGCVQ
..| .. | || | .||||||| ... .. ..   |.|.|       . .||.|||||||||||...  |..|.  |   ..|    . ..|. | | ||
esgesrevahlnfvkwPdhgvPssaaellqfvaevrrlqt.......dagPivvhcsaGiGrsGtlitidvvlglierdkefdvkeivrklreqrqgvvq

TPHQWLYMLLVAHDYL
|  |....  .. . |
tkdqyifvykailevl
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 20-234 6.5e-51 167.9 In-house 37-244 (250) alignment 
Range on Protein: 20-234
Range on HMM: 37-244/250.0
ASYINGNWMDGFSQSREYIVTQGPLPNTIDAFWRMVWEFKVCQIVMITNLKEKGRVkCEKYWPFEGEQlKIGDLILLCEEVKLHAAFQVAQLRVVHRHTG
. |||  ...|..... .|.|||||..||  |||||.| |.  |||.|||||.... ...||| |. . | ||. .   . . .| ... .| . ...  
sdyinasflhgyderkafiatqgPlqatiedfWrmvleeksgtivmLtnLkesekt.yhqywPvekae.kyGdvtvsllskeefadytkrklklskakka

VAHTVHHLWFQDWPDHGVPDTTEAVIDLLltsRelRTRALASREQVAPIAVHCSAGIGRSGVFVGCDILLQQAESFGQVDALGALCHMRRARGGCVQTPH
   .| .| |  ||| |||....||..||   .  . .|   . . ||. |.||||.|||| |.  | .|....   .||    .  .|. | . |.. .
derivrqlhfvvWPdkgvPevatavLell...k..kvqasqqqagnaPvivqCsaGvgrsGafiaidavlerlkkekvvdvfkvikvlrkdrphavesle

QWLYMLLVAHDYLAK
|. ..  ..  .|  
qyvfvyeiilkalds
subfamily_PTPRA_pd Subfamily PTPRA 20-231 6.5e-51 168.2 In-house 86-294 (330) alignment 
Range on Protein: 20-231
Range on HMM: 86-294/330.0
ASYINGNWMDGFSQSREYIVTQGPLPNTIDAFWRMVWEFKVCQIVMITNLKEKGRVKCEKYWPFEGEqLKIGDLILLCEEVKLHAAFQVAQLRVVHR---
. |||  ..||. .  ..| .|||. .|.. ||||.||.| . |||.|.|||. . ||..||| ||  .  |.. .  |....  .. | .. | .    
sdyinasfidGykekdkfiaaqGPkeetvedfwrmiweqksativmltelkerkeekcaqywPdeGl.vtyGnirvevedetvlvdytvrkflvqqlpda

-HTGVAHTVHHLWFQDWPDHGVPDTTEAVIDLLLTSRELRtralasREQVAPIAVHCSAGIGRSGVFVGCDILLQQAESFGQVDALGALCHMRRARGGCV
 .   .  |. . |. ||| ||| ..  ...||   ..|.      . .  || ||||||.||.| |.  | .|.. .. ..||  ... ..|  |   |
trekksrlvrqfhftswPdvGvPfepiGmlkllkkvkkln......qqsagpivvhcsaGvGrtGtfivldavlervkaerkvdvfefvkrlrlqrpqmv

QTPHQWLYMLLVAHDY
||  |. ..  |  .|
qtdeqyefiykvlley
subfamily_PTPRK_pd Subfamily PTPRK 12-225 7.6e-51 167.8 In-house 62-270 (314) alignment 
Range on Protein: 12-225
Range on HMM: 62-270/314.0
LLTLHPS-PASYINGNWMDGFSQSREYIVTQGPLPNTIDAFWRMVWEFKVCQIVMITNLKEKGRVKCEKYWPFEGEQlkIGDLILLCEEVKLHAAFQVAQ
| |..    . |||....|.. .....|||||||..|.  |||.|.. . . |||.|.|.|.||||| |||| ..|.   ||. . . |..|.| . |  
litidgdpssdyinaalidsykrpaafivtqgPlqetvkdfWrlvydencasivmltelvevgrvkClkyWPedtev..ygdikvelvetellaelvvri

LRVVH--RHTGVAHTVHHLWFQDWPDHGVPDTTEAVIDLLLTSRELRTRalasreQVAPIAVHCSAGIGRSGVFVGCDILLQQAESFGQVDALGALCHMR
.|| .  |     ..|... |  ||||.||   .....|.    . .        .  .| |||||| ||.|.|. .||.|. .|  | ||   |   .|
frveklargqeeirevrqfqflgWpdhdvPvsatgllklvrrvkksqee......eaGrivvhCsaGaGrtGtfiaidivldmieregvvdvfnavktlr

RARGGCVQTPHQWLYML
  .   |.|  |. .. 
srkvnmveteeqykfiy
subfamily_PTPN6_pd Subfamily PTPN6 20-232 2.1e-50 166.4 In-house 81-297 (306) alignment 
Range on Protein: 20-232
Range on HMM: 81-297/306.0
ASYINGNWMDGFS--QSREYIVTQGPLPNTIDAFWRMVWEFKVCQIVMITNLKEKGRVKCEKYWPFEGEQLKIGDLILLCEEVKLHAAFQVAQLRVVH-R
. |||.| ... .  ....|| ||| |..|.  ||||||. .   |||.|.  |.|. || .||| | |. . |.. . . . | .|.... .|.| . .
sdyinanyikkevkgsdksyiatqgclettvsdFWrmvwqensrvivmttkevErgkekCarYWPdeeekeeyGkisvtnvseksladYilRelsvskkk

HTGVAHTVHHLWFQDWPDHGVPDTTEAVIDLLLTSRELRTrALASReQVAPIAVHCSAGIGRSGVFVGCDILLQQAESFG---QVDALGALCHMRRARGG
. . ...|... |..|||||||  ..||.|.| . .. .   |... .  || ||||||||| | |.  ||||.. |. |   ..|   .   .|. | |
kkkeerevfqyhfksWPdhgvpkdpgavLdfledvnrkqe.eleea.eagpivvhCsaGiGRtGtfiviDillkliekkgldadidiqklvksvreqrsg

CVQTPHQWLYMLLVAHDYL
 ||| .|. ..  . . |.
lvqteqqykfvykaikkyi
subfamily_PTPN1_pd Subfamily PTPN1 14-222 1e-48 160.6 In-house 50-261 (290) alignment 
Range on Protein: 14-222
Range on HMM: 50-261/290.0
TLHPSPASYINGNWMDGFSQSREYIVTQGPLPNTIDAFWRMVWEFKVCQIVMITNLKEKGRVKCEKYWPFEGE--QLKIGDLILLCEEVK--LHAAFQVA
.|. .   ||| . ..     |.||.||||||||.| ||.|||| |   .||. .. ||...|| .||| . |  .|.. |  |  . ..   .  ..| 
kleradndyinaslveleeakrsyiltqGPlpntvdhfWqmvWeqkskavvmlnkvvekeqikcaqywPqgeeekellledtklkvkliseerksyytvr

QLRVVHRHTGVAHTVHHLWFQDWPDHGVPDTTEAVIDLLLTSRElrTRALasREQVAPIAVHCSAGIGRSGVFVGCDILLQQAESFGQ---VDALGALCH
.|..  ..|  .... |  .  ||| |||..  | ...|   ||  . .|   ..| |  .|||||||||| |.  | .| . |  ..   ||    |..
llelenlktqetreilhfhyttwpdfgvpespaaflkflfkvre..sGsl..ssdvGpavihcsaGiGrsGtfclvdtclvliekkddlssvdikkvlle

MRRARGGCVQTPHQWL
.|. | | .||. |  
lrkyrlGliqtadqlr
subfamily_Ptp69D_pd Subfamily Ptp69D 20-227 2.6e-48 159.7 In-house 76-281 (307) alignment 
Range on Protein: 20-227
Range on HMM: 76-281/307.0
ASYINGNWMDGFSQSREYIVTQGPLPNTIDAFWRMVWEFKVCQIVMITNLKEKGRVKCEKYWPFEgEQLKIGDLILLCEEVKLHAAFQVAQLRVVHRHTG
..||| ... |. .....|. |.|. .||. ||||..| .|  |||..||.|| | ||.|||| | .. . ||..  . . . |  .   .| | . .  
sdYinasfikgykekkkfiaaqdPveatigDfWRmiaeqevtlivmlsnlteknrkkcakYWpie.devqygdilvklvseekhsdyiiReldvskkkee

V-----AHTVHHLWFQDWPDHGVPDTTEAVIDLLLTSRELRTRAlasreqVAPIAVHCSAGIGRSGVFVGCDILLQQAESFGQVDALGALCHMRRARGGC
.      . |    .. |.|  ||........|.   |||           .|| |||||| ||||.||  |.|||| .   .||     ...|. |   
sgevedsrkvvqyhytgWkDskvPevargllklieqvrelykln......rsPivvhCsaGvgrsgifvaldsllqqlkaedkvdifetvkdLrsqRnll

VQTPHQWLYMLLV
||  .|. ..   
vqsleqYvflyra
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 20-223 2.6e-47 156.0 In-house 65-268 (287) alignment 
Range on Protein: 20-223
Range on HMM: 65-268/287.0
ASYINGNWMDGFSQSREYIVTQGPLPNTIDAFWRMVWEFKVCQIVMITNLKEKGRVKCEKYWPFEGEQLKIGDL-ILLCEEVKLHAAFQVAQLRVVHRHT
..||| |.. .. .  ..|..|||.. |.  |||.|.| ... ....|   |..| || ||||     ...|   . | .  ...  . |  ||... .|
sdyinanyvasytddeafiaaqgPiaatvrdfwravletrsasvitmtreveearlkcykywPerevPmrvGGysvvlldydikePeygvralrlidlet

GVAHTVHHLWFQDWPDHGVPDTTEAVIDLLLTSRElRTRALASREQVAPIAVHCSAGIGRSGVFVGCDILLQQAESFGQVDALGALCHMRRARGGCVQTP
  |. |. | . .|||.... |. ..| . |  .. .  .  . ..| |. ||...||||||...   .|... |. |.||.  .. ..|  | . ||..
rearvvkqldllswPdkvlaPtavglirfvldvkq.hielardasevGPlvvhddvGiGrsGillatlvlvsrledlGrvdvaavvirlreyraalvqav

HQWLY
 |. .
vqlrl
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 19-234 5.3e-47 155.1 In-house 75-285 (290) alignment 
Range on Protein: 19-234
Range on HMM: 75-285/290.0
PASYINGNWMDGFSQSREYIVTQGPLPNTIDAFWRMVWEFKVCQIVMITNLKEKGRVKCEKYWPFEGEQLkIGDL-ILLCEEVKLHaAFQVAQLRVVHRH
. .|||  ...|......||.||||..||.  ||...|. ||. |||.|| .|.|.||| .||| .. .  .|   | | .| .|.  .   .|.| ...
tneyinAcyikgykekkqyiatqgpvsntlvdFWkliwqekvtiivmltniieegkvkCqqYWpdsdtka.ygefsikllneetln.eyierklevknkn

T-GVAHTVHHLWFQDWPDHGvpDTTEAVIDLLLTSRELRTRAlasREQVAPIAVHCSAGIGRSGVFVGCDILLQQAESFGQVDALGALCHMRRARGGCVQ
. | ...|... .. |...|  . |.    ||. ..  .|.    ..   .| ||||...|||.||.  .. ...... |..| .  | ..|  . | ||
sagakqsvtqyqitnwdstg..kvtnpqtillvieemyktqr...krgntsivvHCSdtvgrsavfcaaattinkcktegvidvfqvlksqRiqkpgsvq

TPHQWLYMLLVAHDYLAK
| .|  ..  .   || .
tvqqyqgifqivltylds
subfamily_PTPN14_pd Subfamily PTPN14 22-232 6.1e-46 151.8 In-house 78-296 (300) alignment 
Range on Protein: 22-232
Range on HMM: 78-296/300.0
YINGNWMDG--FSQSREYIVTQGPLPNTIDAFWRMVWEFKVCQIVMITNLKEKGRVKCEKYWPFEG---EQLKIGDLILLCEEVKLHAAFQVAQLRVVHR
|||   .     ...|.|||.||||..|.  ||.|||| .|  |||.|. .|.|. |. ||.| ..   .... |   .  . ..   ..   .|.. | 
yinassikvsvggkersyivaqgPleltvqdfWqmvWeqgvqlivmlteeeedgkeksfkyfPkleskkktvefgkfkvttkfsedsdsvittglklkhl

HTGVAHTVHHLWFQDWPDHGVPDTTEAVIDLLLTSRELRTRALASR---EQVAPIAVHCSAGIGRSGVFVGCDILLQQAESFGQVDALGALCHMRRARGG
 ..   ||.|| ..||||||||.  .  .. |   . .| ..  ..   |.  |. ||||||.||.|| .  |.|..  |   ..|   .| ..|. |  
pskeertvwhlqytDWpdhgvPeDvkgflsyLeevqsvrrktnseveskeskPPvlvhCsaGvGrtGvlilsdlliatlehneeidikkvlarLreqrml

CVQTPHQWLYMLLVAHDYL
 |||  |. ..  |   ||
lvqtlaqYkfvYkvlikyl
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 17-224 1.4e-45 150.6 In-house 74-271 (315) alignment 
Range on Protein: 17-224
Range on HMM: 74-271/315.0
PSPASYINGNWMDGFSQSREYIVTQGPLPNTIDAFWRMVWEFKVCQIVMITNLKEKGRVKCEKYWPFEgeQLKIGDLILLCEEVKLHAAFQVAQLRVVHR
 . . |.| |..||... | || .|||...... |||.|.| .. .|||.||| |. . |.||||| .  ..  | . .   . . .  . |  | || .
dphsdyvnanfidGynkkrryiaaqgpnvasvkdfwrlvfeedigkivmltnlvegekrkaekywpdk..kviyGkitvtrkseevnteytvrtlsvvfg

HTgvAHTVHHLWFQDWPDHGVPDTTEAVIDLLLTSRELRTralasrEQVAPIAVHCSAGIGRSGVFVGCDILLQQAESFGQVDALGALCHMRRARGGCVQ
     ..|  | .  ||| |||  | ....|  | .  .|      ..|..| ||||||.||.| |.  | .|.|||    .|   ..  .|. | . ||
dn..irevvqlhytswpdmgvpkytiplmnlirtvkqhht......nsvgaivvhcsaGvGrtGtfitldavldqaeaenaidvynfitgvrqnrikmvq

TPHQWLYM
. .|. ..
vaeqyqfi
0041856 (Phosphotyrosine protein) phosphatases II 16-231 2.9e-44 146.2 In-house 15-170 (182) alignment 
Range on Protein: 16-231
Range on HMM: 15-170/182.0
HPSPASYINGNWMDGFSQSREYIVTQGPLPNTIDAFWRMVWEFKVCQIVMITnlkekgrvkCEKYWPfegeqlkigdlillceevklhaafqvaqlrvvh
|. . .||| |...|   ....|.|||||..|. .|.||..| ..  ||..|         .| |||                                 
hsrdldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt.........eelywp.................................

rhTGVAHTVHHLWFQDWPDHGVPDtTEAVIDLLLTSRElrtralasreQVAPIAVHCSAGIGRSGVFVGCDILLQQaesfgQVDALGALCHMRRARGGCV
  . . ........  |||||||| .. ..|.. . .|          .  |..||||||.||.|..|........     .|..  |....|..| |.|
..ellerlgiqylylpwpDhgvpd.ldelldfieevle..........eggpvlVHCsaGvgRtgtlvaaylmkkl.....gvsleeavklvrsrRpgmv

QTPHQWLYMLLVAHDY
.||.|. .  |.....
itpnqyfflqlallel
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 20-233 4.6e-44 145.5 In-house 72-278 (315) alignment 
Range on Protein: 20-233
Range on HMM: 72-278/315.0
ASYINGNWMDGFSQSREYIVTQGPLPNTIDAFWRMVWEFKVCQIVMITNLKEKGRVKCEKYWPF-EGEQLKIGDLILlcEEVKLHAAFQVAQLRVVHRHT
  |||   . .. . . || .||||. ..| |||||.. ||  |||.|...|  ..|| .|||  ...  . | . .  | ..|.|  .  . ..| |..
sdyinasyiksvdddkayiasqgPlkasvddfwrmvlqekvttivmvtkkqegdkikcrqywPdrkadsvefGsikv..ellsleadtdgvarklvtrks

GVAHTVHHLWFQDWPDHGVPDTTEAVIDLLltsRELRTRalaSREQVAPIAVHCSAGIGRSGVFVGCDILLQQAESFGQVDALGALCHMRRARGGCVQTP
   .||    |..|||.||.  | ... |.   .|...     ...  .. ||||||.||.||..  |  ..|..    || .  .  .|. |   ||| 
eesrtvtqfqftewPdkGvdkqtssllkli...kevkad...ngkkefsllvhcsaGvGrtGvvisidevvaqikrtrsvdvfnfvknlrakrpylvqte

HQWLYMLLVAHDYLA
 .. ..  .  ..| 
eeyafiydavledll
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 21-228 1.2e-43 144.7 In-house 90-289 (319) alignment 
Range on Protein: 21-228
Range on HMM: 90-289/319.0
SYINGNWMDGFSQSREYIVTQGPLPNTIDAFWRMVWEFKVCQIVMITnlkekgRVKCEKYWPFEGEQlKIGDLILLCEEVKLHAAFQVAQLRVVH-RHTG
 |||  ...|. .   || .||||.||.. ||||.||.... ||..|      . || .||| .... | .   .  . |.  | . | .... .  .  
dyinasfvtGyqrkdkyiaaqGPldntladfWrmiweyncstivllt......kdkcsqywplkivi.keerfkvkvdsveetaeyvvrdielsedgkek

VAHTVHHLWFQDWPDHGVPDTTEAVIDLLLTSRELRTRalasREQVAPIAVHCSAGIGRSGVFVGCDILLQQAESFGQVDALGALCHMRRARGGCVQTPH
    ..   |. |||.|||| .  .. |.   | |...     .. |.| ||||||.||.||..  |.||.. .   |||    .  .|. |   ||   
dirkitqfhflGwpdvGvpdypsdlmrlvkkvrhltsk....enhranivvhcsaGvGrtGvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlv

QWL--YMLLVA
|.   |. |. 
qykfiysalle
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 21-229 1.5e-43 144.4 In-house 54-254 (284) alignment 
Range on Protein: 21-229
Range on HMM: 54-254/284.0
SYINGNWMDGFSQSREYIVTQGPLPNTIDAFWRMVWEFKVCQIVMITnlkekgRVKCEKYWPFEGEQlKIGDLILLCEEVKLHAAFQVAQLRVVH-RHTG
 |||  .. |. .   || |||||.||.. ||||.||.... ||..|      . || .||| .... | .   .  . |.  . . | .... .  .  
dyinasfitGyqrkdkyiatqGPldntladfWrmiweyncstivllt......kdkcsqywplkivi.keerfkvkvdsveeseeyvvrdielsedgkek

VAHTVHHLWFQDWPDHGVPDTTEAVIDLLLTSRELRTRalasREQVAPIAVHCSAGIGRSGVFVGCDILLQQAESFGQVDALGALCHMRRARGGCVQTPH
   ...   |. |||.|||| .  .. |.   | |...     .. |.| ||||||.||.||..  |.||.. .   |||    .  .|. |   ||   
dirkirqfhflgwpdvgvpdypsdlmrlvkkvrhltsk....enhranivvhcsagvgrtgvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlv

QWL--YMLLVAH
|.   |. |. .
qykfiysallee
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 15-232 2.1e-43 143.3 In-house 66-278 (287) alignment 
Range on Protein: 15-232
Range on HMM: 66-278/287.0
LHPSPASYINGNWMDGFSQSREYIVTQGPLPNTIDAFWRMVWEFKVCQIVMITNLKEKGRVKCEKYWPFEGEqLKIGDLILLCEEVKLHAAFQVAQLRVV
|.     |||  ..||.......|....|. ||.  ||..... .|  |||....||. . .| .||| |   . .|.  .   . . .| . . .|.| 
lkgehpdyinavfidgykekkafiiaesPmfntarnfWkliddrnvtaivmlcqekendeevcyqyWpeeks.vvlGeyniellneevnagyierklevk

HRH-TGVAHTVHHLWFQDWPDHG-VPDTteaVIDLLLTSRELRTRAlasREQVAPIAVHCSAGIGRSGVFVGCDILLQQAESFGQVDALGALCHMRRARG
... .|  ..|.   . .|...| |..       ||.  .  .|.    ..  ..| ||||...|||..|.  .. .....  | .| .  | ..|  . 
nknkagdkqqvkqyqitnWdstgkvtep...qtillvieemyktqr...krgntsivvhCsdtvGrsamfcaaattinkckteGviDvfqvlksqriqkp

GCVQTPHQWLYMLLVAHDYL
| ||| .|. ..  .   ||
gsvqtveqykfindivleyl
subfamily_CG7180_pd Subfamily CG7180 20-228 3.8e-43 142.2 In-house 70-286 (296) alignment 
Range on Protein: 20-228
Range on HMM: 70-286/296.0
ASYINGNWMDGFSQSREYIVTQGPLPNTIDAFWRMVWEFKVCQIVMITNLKEKGRvKCEKYWPFEGeQLKIGDLILLCEEVKLHAAFQVAQLRVVHR---
  |||  ..|.| . .|||||..|  .|.|.|||.|.. ..  .|..|.  .  . .. .||| .. . . |....   |.|  |...  .......   
sdYinavyvdsflkkkeyivteapkketvdefWrlvydeeisavvvLtktfdfak.mypsywpnks.keqygeifveiveekqyanlkirtfkltkkiva

----HTGV---AHTVHHLWFQDWPD-HGVPDTTEAVIDLLLTSRELRTRAlASREQVAPIAVHCSAGIGRSGVFVGCDILLQQAESFGQVDALGALCHMR
    ...|     .|... .. |.  . ||  |.|.|.|.   | .| ..   ... .|. |..| | .||||... |. |...|  ..||  .|.  .|
lteqekqvkaetRivklfqlteWeledkvPlstnalielrrrvrlwrekv.dedpeegPvvvvssdGasRsGvylaidanlelvekeeevdvFeavktlr

RARGGCVQTPHQWLYMLLVA
| | . |.. ... |.  | 
rsRpqLvenveeYkyiYdvl
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 19-233 6.7e-43 141.5 In-house 69-277 (515) alignment 
Range on Protein: 19-233
Range on HMM: 69-277/515.0
P-ASYINGNWMDGFSQSREYIVTQGPLPNTIDAFWRMVWEFKVCQIVMITNLKEKGRVKCEKYWPF-EGEQLKIGDLILlcEEVKLHAAFQV--AQLRVV
|   |.|   . .|   . || .|||.. ..| |||.|.. .|  |.|.|.|||  ..|| ||||   |. .| | . .  | | |.|  .    .|.|.
PhsdyfnasyipsfdndkayiasqgPnkasvddfWrlvlqenvttiamvtklkegdkikcgkyWPdkpgdsvkfGsikv..elvsleactggikrkltvl

HRHTgvAHTVHHLWFQDWPDHGVPDTTEAVIDLLltsRELRTRalASREQvAPIAVHCSAGIGRSGVFVGCDILLQQAESFGQVDALGALCHMRRARGGC
.     ..||    |..|||.|||  | ... |.   .|...    .. .  |. .|||||.|| ||..  |  . .|.    || .  .  .|. |   
kgdd..srtvtqfhfteWPdkGvpkhtssllkli...kevkad..hgqyt.hpliihcsaGvGrtGvvisidsvvahakttrmvdvfnfvtnirqkrpyl

VQTPHQWLYMLLVAHDYLA
|||  |. ..  .  ..| 
vqtqeqyafiygavledll
0051429 (Phosphotyrosine protein) phosphatases II 21-234 3e-42 140.5 In-house 5-227 (272) alignment 
Range on Protein: 21-234
Range on HMM: 5-227/272.0
SYINGNWMDGFSQ---SREYIVTQGPLPNTIDAFWRMvWEFKVCQIVMITNLKEKGRVKCEKYWP-----------FEGEQLKIGDLILLCEEVKLHAAF
.||| ....|. .    . .. ..||||.|.. |||. .| ..  ||..... |.||.||..|||           .. ..  .|.| . . ...|.  .
gyiNardvggygrvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseellldy

QVAQLRVVHR-HTGVAHTVHHLWFQDWPDHGVP-DTTEAVIDLLLTsrelrtralasreqVAPIAVHCSAGIGRSGVFVGCDILLQQAESFGQVD-----
 .  |....  ..| |..|.||...|||||||| ..  ....|||.                |. ||||||..|.|..| ...||.. .    ||     
ilrellltlllsagearevmhlhytdwpdhgvpqeallellellld..............ggpvlvHCsaGkdRTGtvvallllllgvsletivddYllt

---ALGALCHMRRARGGCVQTPHQWLYMLLVAHDYLAK
   ...|. ..|..| | |||..|.|. . .. ..| .
nlyleeaveelraqrpgavqteeqylflyeallellrs
0036282 (Phosphotyrosine protein) phosphatases II 21-224 5.5e-42 138.7 In-house 3-162 (174) alignment 
Range on Protein: 21-224
Range on HMM: 3-162/174.0
SYINGNWMDGFSQSREYIVTQGPLPntidaFWRMVWEFKVCQIVMITNLKEKGRVKCEKYWPFegeqlkigdlillceevklhaafqvaqlrvvhRHTGV
.||| ...|..  ....|..||||.     ||.|..|...  .|| ...||.|..||  |||                                 ...  
dyinaspldlsyitprliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe................................lredl

AHTVHHLWFQDWPDHGVPDTTEaVIDLLLTSRELRTRalasrEQVAPIAVHCSAGIGRSGVFVGCDILLQQAEsFGQVDALGALCHMRRARGGCVQTPHQ
 ........  ||||||||... .....   .| . .      .  |..||||||.||.|..|.....|.. .  . ||||  .  .|. |.|.||||.|
erlgiqylylpwpDhgvpdlsi.llefvkfveealse.....dpggpvlVHCsaGvgRtGtlvaaylmlrgll.eslvdaldlvrelRlqrpgmvqtpsQ

WLYM
. . 
yrfl
subfamily_PTPN23_pd Subfamily PTPN23 20-220 1.9e-40 133.5 In-house 67-268 (288) alignment 
Range on Protein: 20-220
Range on HMM: 67-268/288.0
ASYINGNWMDGFS-QSREYIVTQGPLPNTIDAFWRMVWEFKVCQIVMITNLKEKGRVKCEKYWPFE-GEQLKIGDLILLCEEVKLHAAFQVAQLRVVHRH
  |||  .. . | .. ..|.||.||..|.  ||.||.| |.  |||... .|.|. |...||| . ||  | ||| . ...|.    .   .|.. ...
DDYinAsfvkdlspgcPdfiatqaPlqstlnDFWlmvyeqkssviVmllskeelgkpkvdrYwPedkgetvkfgdlsvtlksvretethvervlkletld

TGVAHTVHHLWFQDWPDHGVPDTTEAVIDLLLTSRELRTraLASREQVAPIAVHCSAGIGRSGVFVG-CDILLQQAESFGQVDALGALCHMRRARGGCVQ
.   ..| || .. ||..|||.. | ....|   ..  .     |.  .|. ||||||.||.|||     .. .  .  | .| .  . ..|. |   ||
adavksvshlqltsWpelGvPasPetllqfldevesaye..avqrksktPlvvhCsaGvgRtgvfalvyaavrelekgnglldiiqvvsrlreqRrfmvq

TPHQ
. .|
ekeq
0043147 (Phosphotyrosine protein) phosphatases II 21-225 1.9e-40 133.7 In-house 6-154 (172) alignment 
Range on Protein: 21-225
Range on HMM: 6-154/172.0
SYINGNWMDGFSQSREYIVTQGPLPNTIDAFWRMVWEFKVCQIVMITNLkekgrvkcekywpfegeqlkigdlillceevklhaafqvaqlrvVHRHTGV
 ||| ...|.    ...|.|||||.||.. ||||..| ..  ||..|.|                                            ..  ...
dyinasyldlyyipdrfiatqgplrntladfwrmlkelgithivnltel............................................lydpell

AHTVHHLWFQDWPDHGVPdTTEAVIDLLLTSRELRtralaSREQVAPIAVHCSAGIGRSGVFVGCDILLqqaesfGQVDALGALCHMRRARGGCVQTPHQ
 ... ....  ||||||| ..| ....|   .||       ...  |..||||||.||.|..| ....|       ..... |....|..|.|.||.|.|
erlgiqylylpwpDhgvp.llellleflefidell.....alspggpvlVHCsaGvgRtgtlvaaylml......lglsleeavalvrekRpgavqnpsq

WLYML
. . .
yrfly
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 11-225 3.1e-40 132.9 In-house 48-257 (283) alignment 
Range on Protein: 11-225
Range on HMM: 48-257/283.0
ALLTLHPSPASYINGNWMD---GFSQSREYIVTQGPLPNTIDAFWRMVWEFKVCQIVMITNLKEKGRVKCEKYWPFEGEQlKIGDLILLCEEVKLHAAFQ
  . |.. . .|||  ..       |...||..|.|| .|.  ||.||.. |.. |||.|.|.|  |.|| .||| .| . . |.. .  ..   . .| 
wrvelksesrdyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfdekitaivmltklqedlrikCsqyWPkrGse.dyGeftvtlrkettsnsfi

VAQLRVVHR-HTGVAHTVHHLWFQDWpdhgVPDTTEAVIDLLLTSRELRTraLASREQVAPIAVHCSAGIGRSGVFVGCDILLQQAESFGQVDALGALCH
. .| . .   .  .  . |  ..||    .    .|.|. |.    ...  |  ... .|| ||||.||||..||..    ...| .   ||    .  
ikelllrvnssakstlllahyqvidW....leygeqaiinslvkfnkvis..lqteskkgPivvhCstgiGrtavfiaasasvkdaltesvvdvfavvki

MRRARGGCVQTPHQwlYML
||  | . |||  |  |.|
mreqrmmavqtldq..ykl
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 19-227 1.3e-39 130.6 In-house 80-278 (290) alignment 
Range on Protein: 19-227
Range on HMM: 80-278/290.0
PASYINGNWMDGFSQsrEYIVTQGPLPNTIDAFWRMVWEFKVCQIVMITNLKEKGRVKCEKYWP-FEGEQLKIGDLILLCEEV-KLHAAFQVAQLRVVHR
.  |.  |...|      .|.|||.| .|.  .|||| . ||  |||. .| |.|. |||.|.|  ||| | .|.. .|| |  .  |  .   | | ..
dGdyvhanyvkGlka..mfiltqGalkdtvidiwrmvlqekvaaivmlceliedGkakceqyypekeGevltfGeitvlcseeddkdaniikktlsvrdk

HTGVAHTVHHLWFQDWPDHGVPDTTEAVIDLLltsRELRTralasreQVAPIAVHCSAGIGRSGVFVGCDILLQQAESFGQVDALGALCHMRRARGGCVQ
..|  | ..||  . |||. |. .| |.. .|   | ||.          |..|||||||||.| ||  .. ||      ..| |.    .|..| . ||
dsGkehklkhlkikswpdksvalstlallrtl...rilrk.......asGpvvvhcsaGiGrtGtfvaievglqilldGkeldlldlvralrnsrlnsvq

TPHQWLYMLLV
   |.| .. .
vdiqylalvei
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 16-233 1.8e-39 130.2 In-house 66-294 (301) alignment 
Range on Protein: 16-233
Range on HMM: 66-294/301.0
HPSPASYINGNWMDGFSQSREYIVTQGPLPNTIDAFWRMVWEFKVCQIVMITNLKEKGRVKCEKYWPF-EGEQLKIGDLILLCEEVKLHAAFQVAQLRVV
. .  .||| ...||.|.....|..|||. .|.  |||..|. |. .|||.|||||. . |||.|||  | |. . | .  .  . . .  | . || |.
dlcqreyinasyidgysekkkfiaaqgpmkktlvdfWrliwqekpvsivmvtnlkegtkskceqywpnseaeseefgpftvtlvneqvyPdfvirqlnvk

HRHTG---------------VAHTVHHLWFQDWPDHGV---PDTTEAVIDLLLTsrelRTRalasREQVAPIAVHCSAGIGRSGVFVGCDILLQQAESFG
 ...                 ...|  |   |||..||   | |   |||  .     |..    .   .|. ||||....||||..  .| | |. . |
iqdgsnngyierkfkvksdksswdvlqlqvtdWpqdGvvreprtvLqviddvih....rqq....kigggpvvVHCSdtVsrsGvYcsvsiglEQckaeg

QVDALGALCHMRRARGGCVQTPHQWLYMLLVAHDYLA
 ||  .    .|| . | |.|  |.  .  | . ||.
VVdvfqvtkavrrskpgaVtTLeqytsiydvidmylq
0046846 (Phosphotyrosine protein) phosphatases II 14-229 1.9e-39 130.5 In-house 6-170 (176) alignment 
Range on Protein: 14-229
Range on HMM: 6-170/176.0
TLHPSPASYINGNWMDGFsqsrEYIVTQGPLPNTIDAFWRMVWEFKVCQIVMITNLKEKGRVKCEKYWPFeGEQLKIgdlillceevklhaafqvaqlrv
. .. . .|||.|...|      .|.||||||.|. .|..|..| ..  .|..|...|.||.||  |||   |.|.|                       
lgldldldyinanlilgs....rpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpe.leklgi.......................

vhrhtgvahtvhHLWFQDWPDHGVPDTtEAVIDLLLTSRELRTRAlasreqvAPIAVHCSAGIGRSGVFVGCDILLQQaesfGQVDALGALCHMRRARG-
            . .. .||||||||  |....||   || ...         |..|||||||||.|..| ...|  .     ..... ||...|. |  
............qylhlpwpDhgvpdl.elllellefirealkeg.......gpvlVHCsaGigRtgtlvaayllele....kglsveealalvreqRpl

GCVQTPHQWLYMLLVAH
|.||||.|. .   ...
gavqtpeQyrflyefel
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 20-232 1.9e-39 130.6 In-house 79-284 (297) alignment 
Range on Protein: 20-232
Range on HMM: 79-284/297.0
ASYINGNWMDGFSQsrEYIVTQGPLPNTIDAFWRMVWEFKVCQIVMITNLKEKGRvKCEKYWPFEGEQlKIGDLILLCEEVKLHAAFQVAQLRVVHRHTG
. |.|  .. |. .  ..| || | ..|.. ||.||.. .|  |||.....|. . || .||. .| . . ||. .. . |.    |   .| | . .. 
sDyvnasfvkgnkh..rlittqmPmkatvadfWamvldeqvstivmlnddnerdk.kcaryWsdkgvt.tfGdvsvvllsvsereGfikrelevtkgkak

VAHTVHHLWFQDWPDHGVPDTTEAViDLLLTSRELRTRALASREQvaPIAVHCSAGIGRSGVFVGCDILLQQAESFGQVDALGALCHMRRARGGCVQTPH
. . |.   | .|||. |.   .|   ||    |.|       |   |. |||.||.|| ||..  |  . .|.   .|| .| . ..|. |   |||  
arrvvkqyqfveWPdkaverkdsas.sllklisevrkdfsqnaeg..PllvhclaGvGrtgvlltidsvvaeakrekevdifglvkklrqerpylvqtke

QWLYMLLVAHDYL
|. ..  .  ..|
qykfvyvavleal
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 14-223 2.1e-39 130.5 In-house 69-279 (325) alignment 
Range on Protein: 14-223
Range on HMM: 69-279/325.0
TLHPSP-ASYINGNWMDGFSQSREYIVTQGPLPNTIDAFWRMVWEFKvCQIVMITNLKEKGRVKCEKYWPFE-GEQLKIGDLILLCEEVKLHAAFQVAQL
|.. .| . ||| ...  . .   .. .| ||..||. .||.| ... | .|...|  ..|  .| .||| | |.  . | | .    ..  . .   .|
tkkddpssdyinasylrddkkkdvflaaqaPltatindlWrlvldWr.csvvvvlneldlgkdrcavywpkemgksktfGglevklrtieeisdyvhrvl

RVVHRHTGVAHTVHHLWFQDWPDHGVPDTTEAVIDLLLTSRELRTRALASREQVAPIAVHCSAGIGRSGVFVGCDILLQQAESFGQVDALGALCHMRRAR
 |   . | . .|. . .| |.| ||.    ..| .| .  ..  |  |  .  .|| ||||||.||.|||.    .|..     .|| .| . ..|. |
dvkqvkkGetrsvkqfqlqswddmGvqkrpatlisilqlvkavservtantkastpilvhcsaGvGrtGvfislysalakvieesrvdifgfvkklrkdr

GGCVQTPHQWLY
   |.|  |.  
psmvetvdqyil
0049260 (Phosphotyrosine protein) phosphatases II 27-225 2.7e-39 129.6 In-house 1-143 (152) alignment 
Range on Protein: 27-225
Range on HMM: 1-143/152.0
WMDGFSQSREYIVTQGPLPNTIDAFWRMVWEFKVCQIVMITNLKEKGRVKCEKYWpfegeqlkigdlillceevklhaafqvaqlrvvhrhtgvahtvhH
..||. ...|.| ||||.|||.. ||||..| ..  |||.|.| |.|..|||.|.                                            .
fidgyampfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi............................................q

LWFQDWPDHGVPDTTEAVIDLLLTSRELrtralaSREQVAPIAVHCSAGIGRSGVFVGCDILLqqaesfGQVDALGALCHMRRARGGCVQTPHQWLYML
  .  |||||||| .. ...|||  ..|       ...  |..||||||.||.|..| ....|       .|... |. ..|..| | |..|.|. . .
ylhlpwpDhgvpdlsqlllflllfiekl......aldkggpvlVHCsaGvgRtgtlvaaylml......lgvsleeavalvrekRpgavpnpgqlrfly
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 17-224 9.2e-36 118.2 In-house 26-231 (237) alignment 
Range on Protein: 17-224
Range on HMM: 26-231/237.0
PSPASYINGNWMDGFSQ-SREYIVTQGPLPNTIDAFWRMVWEFKVCQIVMITNLKEKGRVKCEKYWPFEGEQLKIGDLILLCEEVKLHAAFQVAQLRVVH
 | . ||| ....||    ..|| .|||| .. | ||.|||. |   |||.| | |. ..|| ||||   .    | | .     .  . . |  | ...
gsgsdyinatylkgfdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywpstdqpaaygvltvslkkkeefsdytvrslllsk

RHTGV-AHTVHHLWFQDWPDHGVPDTTEAVIDLlltSRELRTRALAsREQVAPIAVHCSAGIGRSGVFVGCDILLQQAESFGQVDALGALCHMRRARGGC
|.|      .|   |  |||.|||. | |.. .    ...  |.     . .|  .|||||.||.|.|.  | .|.||.    ||    .  .   |   
rltlkevrlihqyqftswpdrgvpqqtaallrf...rkniinrsph.vsesgpwiihcsagvgrtgiflvidamlrqakekkvvdiynyvysieedrpyi

VQTPHQWLYM
.||  |....
iqtkdqyvfi
subfamily_PTPRN_pd Subfamily PTPRN 21-226 9.3e-36 118.0 In-house 85-286 (297) alignment 
Range on Protein: 21-226
Range on HMM: 85-286/297.0
SYINGN-WMDGFSQSREYIVTQGPLPNTIDAFWRMVWEFKVCQIVMITNLKEKGRVKCEKYWPFEGEQLK-IGDLILLCEEVkLHAAFQVAQLRVVHRHT
 |||    .|   ..  || |||||..|. .||.||||  |. ||..|.|.|.|  .|..||| ||...  | .. |. | .     . |  . .   .|
dyinasaildhdprapayiatqgplastvadfwqmvweqGvvvivnltrleeegvkqckrywpdeGsevyhiyevhlvsehi.wcddylvrsfylknlqt

GVAHTVHHLWFQDWPDHGVPDTTEAVIDLlltsRelRTRALASREQVAPIAVHCSAGIGRSGVFVGCDILLQQ-AESFGQVDALGALCHMRRARGGCVQT
  . ||  . |  ||..||| .. .....    |  |    . | . .|| ||||.| ||.||..  |..|.. .    ..|   .| |.|  | | |.|
setrtvtqfhflswpeegvPasaksllef....r..rkvnksyrGrscpivvhcsdGaGrtGvyilidlvlnrllkGvkeidiaatlehlrdqrpglvkt

PHQWLYMLL
 .|. ..| 
kdqfefalt
subfamily_ptpA1_pd Subfamily ptpA1 20-200 1.6e-35 117.7 In-house 75-265 (418) alignment 
Range on Protein: 20-200
Range on HMM: 75-265/418.0
ASYINGNWMDGfSQSREYIVTQGPLPNTIDAFWRMVWEFKVCQIVMITNLKEKGRVKCEKYWP--FEGEQLKI---GDLILLCEEVKLHAAFQVAQLRVV
. ||| |..|| .  ...|.|||||||||  ||||||| ..  |||..   |. |.||..|||    |||. |   |. ..    |.|    |  .  ..
sdyinanyidg.aypkqfictqgplpntiadfwrmvwenrcriivmlsresencrikcdrywpeqiggeqfsiygngnevfgtysvelveviqdpereii

HRH-----TGVAHTVHHLWFQDWPDHGVPDTTEAVIDLLLTSRELRTRALASREQVAPIAVHCSAGIGRSGVFVGCDILLQQAE-SFGQVDA
 |       | .. . .  .. |||| .|| |. . .|| .  . . . . | ..  || ||||||.||.| |. . |.... .  | |.||
trnirltfegetrditqyqyegwpdhnipdhtqpfrqllhsitnrqnqiipssdrnvpiivhcsagvgrtgtfctavimmkkldhyfkqlda
subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 4-228 3.5e-35 116.2 In-house 61-277 (301) alignment 
Range on Protein: 4-228
Range on HMM: 61-277/301.0
CSPSTlqALLTLHPSPASYINGNWMDGFSQSREYIVTQGPLPNTIDAFWRMVWEFKVCQIVMITNLKEKGRVKCEKYWPFE-GEQLKIGDLILLCEEVK-
| |||  |.  .       |  ||..   ... .|.|||||.|| . || |.  ..| .|||...  ||   |||.| | . .|.|.||   .  .. . 
ckPst..avevivdGkrvPihanwiptsGhphrfiatqgPlkntsedfwamlvqydvekivmlgqkvekleekceeylpvkisekldigrfkikiknkel

-LHAAFQVAQLRVVHRHTG-VAHTVHHLWFQDWPDHGVPDTTEAVIDLLltsrELrtralaSREQVAPIAVHCSAGIGRSGVFVGCDILLQQAESFGQVD
 |.   .  .|.|.       ..|| |  ...|.|.||| .   . ||.    ||       ..   || ||||||||||  |.| ..| .. |.  ...
ilnkkiskrtlevedstgkfatrtvthyqysewtdrgvPkshaelfdlm....el......vkksekPivvhcsaGiGrsvafigteylareveadptie

ALGALCHMRRARGGCVQTPHQWLYMLLVA
   || |.|  |   ||| .|  .| | .
ltealkhlrehrwngvqtnsqlywmtlGt
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 18-225 3.6e-35 116.3 In-house 57-288 (297) alignment 
Range on Protein: 18-225
Range on HMM: 57-288/297.0
SPASYINGNWMDGF--SQSREYIVTQGPLPNTIDAFWRMVWEFKVCQIVMITNLKEKGRVKCEKYWPF-EGEQLKIGDLIL--LCEEVKLHAAFQVAQLR
.   ||| ...      .   ||..|||| .|.| ||..|.|  |  |||...|.| || ||  |||  ..|.|| ||...  | .    .   ....|.
terdyinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmvaklqedGrdkcapywpsvvqerlkagdvvveflsstsdefdrviltelq

VVHRhtGVAHTVHHLWFQDWPDHGVP----DTTE----------------AVIDLLLTSRELRTRAL-ASREQVAPIAVHCSAGIGRSGVFVGCDILLQQ
...|       |.|  |  |||||||    |                   |..... .   |.  .| |   . |.. ||||||.||||| | .|..|..
liyr..sesrvvrhvqflswpdhGvpsdledlvrfqaqvcscciavpmmlalvemftamvflqleslraemprnayllvhcsaGvGrsGvvvlsdvilak

AESFGQVDALGALCHMRRARGGCVQTPHQWLYML
       |.   | ..|  |   ||| .|. .. 
lrkkripdvaailsilreqrarlvqtleqfelly
0049772 (Phosphotyrosine protein) phosphatases II 14-233 3.7e-35 117.6 In-house 66-281 (314) alignment 
Range on Protein: 14-233
Range on HMM: 66-281/314.0
TLHPSPASYINGNWMDGFsqsREYIVTQGPLPNTIDAF----------WRMV--WEFKVCQIVM---------------------ITNLKEKGrvkcE--
.|. |  .||| ...|||   . .|.|||||..|.. |          ||||  ....|  |||                     ...| ..|       
glpvsgsdyinasyvdgf...lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivmsrdevladelsrLdaAlgKtpllildgng....nep

--KYWPFEGeqlkigdlillceevklhaafqvaqlRVVHRHTGVAHT-VHHLWFqDWPDHGVPdTTEAVIDLLLTSRELrtralasrEQVAPIAVHCSAG
  .....                            .... .  . .. ...|.. ..||...| ..| . ..|   .|.        ..  |..|||.||
taadlellk..........................eelydpelferlgikylri.pvpDgsap.lledfdeflefieea........dkggpvlvHCkaG

IGRSGVFVGCDILLQQAesfgQVDALGALCHMRRARG-----GCVQTPHQWLYMLLVAHDYLA
.||.|.|| ...|. .     .|..  || ..|..|      |..... |....| . ..|| 
kgRtgtfvvaaylmkll....gvsleealedvrlkRpinpnpgfieqleqyefilealleylk
0051082 (Phosphotyrosine protein) phosphatases II 21-226 4.3e-35 115.9 In-house 4-147 (151) alignment 
Range on Protein: 21-226
Range on HMM: 4-147/151.0
SYINGNWMDGFsqsreYIVTQGPLPntidAFWRMVWEFKVCQIVMITNLKEKGrvKCEKYWPFEGeqlkigdlillceevklhaafqvaqlrvvhrhtgv
.||| ....|.     .....|||.    .|.....| ..  ||......| |  .| .|.| .|                                   
dyinfsyvtgg.....lyrsggpla....dflellkelgiktivnlrseeerg..ycpeylpelg...................................

aHTVHHLWFQDWPDHGVPDTTEAVIDLLLTSRElrtralasrEQVAPIAVHCSAGIGRSGVFVGCDILLQQaesfgqVDALGALCHMRRARGGCVQTPHQ
 ..|.|... ||||.|.|....||...|   ..          .  |..||||||.||.|..|.....|..      |..  || ..|. |.|.||.. |
.ievlhipildwpdpglplsfdavleflellld.........kkngpvlvHCsaGkgRTGtlvalylmllg......vsleealeeyrlkrpgvvqpnqq

WLYMLL
.|. |.
flfqlf
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 11-232 1.3e-34 114.3 In-house 71-289 (305) alignment 
Range on Protein: 11-232
Range on HMM: 71-289/305.0
ALLTLHPSPASYINGNWMDG-FSQSREYIVTQGPLPNTIDAFWRMVWEFKVCQIVMITNLKEKGRVKCEKYWPF-EGEQLKIGDLILL-----CEEVKLH
|..  .|||. ||  |..   .   . .|..|||| .||| || || . || ||||. .  | |..|| .|||   ||.|..   |..     .  ..  
avkldkpspsdyihanyvgcpmipekrficaqgpldqtidefwwmviqnkveqivmlcktvelgklkcaqywpaaqgeklelksgivvenvsgskpmerd

AAFQVAQLRVVHRhTGVAHTVHHLWFQDWPDHGVPDTTeavidllLTSRELRTralASREQVAPIAVHCSAGIGRSGVFVGCDILLQQAESFGQVDALGA
|  |.. |.. .   .   .| || . .||| |||          ||| || .   | |    || |||||||||.|  |  . .|..     ..  .  
aeiqitllnltys.gdqkmsvrhlqwtewpdrgvppck.......ltslells...airgskvpivvhcsagigrtgtivaieyilekiaenkpcppmpe

LCH-MRRARGGCVQTPHQWLYMLLVAHDYL
| . .|  |   .|.  |.|..  |  .|.
lvkalrdqrafsiqndvqylfihrvmlnyf
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 20-224 1.3e-34 114.4 In-house 76-271 (439) alignment 
Range on Protein: 20-224
Range on HMM: 76-271/439.0
ASYINGNWMDGFSQSREYIVTQGPLPNTIDAFWRMVWEFKVCQIVMITNLKEKGRvkcekYWPFEGEqLKIGDLILLCEEVKLHAAFQVAQLRVVHRH--
. ||| |...|. . . || ||||  .| | |||.|.| |. .|||.||| |  .     ||| ..|    ||... ..       . .  ..|. ..  
shyinanyikGyyddklyiatqgpkkettddfwrlviekktvtivmltnlvesyk.....ywpsdae.vcygdiavrvdrnielpnyvirgfkvfnerdt

TGVAHTVHHLWFQDWPDHGVPDTTEAVIDLLltsRELrtRALASREQVAPIAVHCSAGIGRSGVFVGCDILLQQAESFGQVDALGALCHMRRARGGCVQT
|   .|| .. .  |||. ||  .  |.|.|   | .   .   .|.. |. ||||||.||.|  .  || |.|  .  .||  | .  .|. |   ||.
tekertvlqfhyiawpdknvpaqashvldfl...rai..nsandkeeygpvvvhcsagvGrtGtiialdialeqlklenkvdikgivkvlrkqrkqmvqa

PHQWLYM
  |....
lcqyvfi
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 17-238 1.2e-32 107.9 In-house 70-293 (305) alignment 
Range on Protein: 17-238
Range on HMM: 70-293/305.0
PSPASYINGNWMDGFSQSREYIVTQGPLPNTIDAFWRMVWEFKVCQIVMITNLKEKGRVKCEKYWPFEG-EQLKI---GD-LILLCEE---VKL--HAAF
| |  ||  |..   .... .| || || .|   || | .. || .| |. ||.|||  || .|.. .  ..|..   |. ... .|    .|.  .|. 
pwpheyihanyvstptnpkrfictqaplektcadfwymclqdkveaifmlcnllekgakkcleyfaskdkdvlefeekgqkisvkfessvtlkfrkdaka

QVAQLRVVHRHTG-VAHTVHHLWFQDWPDHGVPDTTEAVIDLLLTSRELRtralasreqvAPIAVHCSAGIGRSGVFVGCDILLQQAESFGQVDAL-GAL
.| .  .|   .|  |. | |  . |||| ||| .  |...||  .| ..           ||.|||||||||.|  |  . .|.|  .  ...     |
kvtetvlviegpgekarkvthyhwidwpdrgvpaadlailellekarpsk..........gpivvhcsagigrtgsvvmleyildqllagqiiedtdkil

CHMRRARGGCVQTPHQWLYMLLVAHDYLAKVSLL
 ..|  |   .|| .|.|..  |  .|. |  ||
qkireqrnnsiqtdaqylfvhqvilnyfrkkkll
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 13-232 1.3e-32 108.1 In-house 60-277 (307) alignment 
Range on Protein: 13-232
Range on HMM: 60-277/307.0
LTLHPSPASYINGNWMDGFSQSREYIVTQGPLPNTIDAFWRMVWEFKVCQIVMITNLKEKGRVKCEKYWPFEGEQ-LKI---GDLILLCEE-V-KL---H
....   . ||  |..    . . .|..|||| ||.  || |. . ||  ..|. .. | ...|||.||| |  | |     .. | . .  . ||   .
vkfdglasdyihanylgiaikpkkficaqgplentqysfwamaiqekvesvimlckvielakikceqywpleegqklvfgeapntisvanlgakklapde

AAFQVAQLRVVHrhTGVAHTVHHLWFQDWPDHGVPDTTEAVIDLLltsrElrtralASREQVAPIAVHCSAGIGRSGVFVGCDILLQQAESFGQVDALGA
   .|..|.|.   .. . |..|| ...|||.|||..  . |.||    |      | | .  |. ||||||.||||  |.  .. ..  .     ..  
dlinvttlkvdw..aqksrtiqhlqwenwpdrgvpqinltainll....e......avrydtnpvvvhcsaGvGrsGtivaislvqdkmiaGinckdmkk

LC-HMRRARGGCVQTPHQWLYMLLVAHDYL
|   .|  |  ..||  |.||.  |  .|.
lveelrsqrhyaiqteaqylylhrvlleyf
0044763 (Phosphotyrosine protein) phosphatases II 17-228 4.6e-31 103.2 In-house 15-167 (178) alignment 
Range on Protein: 17-228
Range on HMM: 15-167/178.0
PSPASYINGNWMDGFsqsreYIVTQGPLpntiDAFWRMVWEFKVCQIVMITNLKEKGRVKCEKYWPFEGEqlkigdlillceevklhaafqvaqlrvvhr
.  . ||| ......     ..... |      .......| ..  ||..|. .| |..|| .||| | .                              
lersdyinaseilpg.....lylgslpp....addlellkelgithivnlteelelgflkcdpywpeeag..............................

htgvahtVHHLWFqDWPDHGVPDTTEAVIDLLLTSRELRtralaS-REqvAPIAVHCSAGIGRSGVFVGCDILLQQaesfgQVDALGALCHMRRARGgCV
       ...|..  .||||||| .| . ...   .|..     . ..   |..||||||.||||..| .......     ....  |. ..|..|  .|
.......iqylhi.pipDhgvpdllehflefvefieeal.....dekg..gpvlVHCsaGvgRsgtlvaaylmkkl.....glsleeaielvrerRp.iv

QTPHQWLYMLLVA
..|.|. ......
pnpgqlrqLyefe
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 20-226 4.9e-31 102.7 In-house 36-235 (239) alignment 
Range on Protein: 20-226
Range on HMM: 36-235/239.0
ASYINGNWMDGFSQS-REYIVTQGPLPNTIDAFWRMVWEFKVCQIVMITNLKEKGRVKCEKYWPFEGEqlKIGDLILLCEEVKLHAAFQVAQLRVVHRHT
. ||| ...  .  | . || ||| .  .   ||||.|. . | |||.| | |  . || .|||      |  .| .   . .. | . .  . . .   
sdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdsts..kycnlrvtlrktevfadyiirtfvmsqvgq

GVAHTVHHLWFQDWPDHGVPDTTEAVIDLlltSRELRTRalaSREQVAPIAVHCSAGIGRSGVFVGCDILLQQAESFGQVDALGALCHMRRARGGCVQTP
   . |..  |  |||.|||. . ||. |    |..      |     |  .|||||.||.| |.  | .|.||.    || .  .  .|  |   ||| 
teeryvyqyhftvwpdkgvpqyatavlgl...rrkitkd...slpgarpwvihcsagvgrtgaflvidamlrqakkqktvdifnyvkairedrphmvqts

HQWLYMLL
 |.... |
eqyvfihl
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 20-226 4.9e-31 102.7 In-house 35-234 (239) alignment 
Range on Protein: 20-226
Range on HMM: 35-234/239.0
ASYINGNWMDGFSQS-REYIVTQGPLPNTIDAFWRMVWEFKVCQIVMITNLKEKGRVKCEKYWPFEGEqlKIGDLILLCEEVKLHAAFQVAQLRVVHRHT
. ||| ...  .  | . || ||| .  .   ||||.|. . | |||.| | |  . || .|||      |  .| .   . .. | . .  . . .   
sdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdsts..kycnlrvtlrktevfadyiirtfvmsqvgq

GVAHTVHHLWFQDWPDHGVPDTTEAVIDLlltSRELRTRalaSREQVAPIAVHCSAGIGRSGVFVGCDILLQQAESFGQVDALGALCHMRRARGGCVQTP
   . |..  |  |||.|||. . ||. |    |..      |     |  .|||||.||.| |.  | .|.||.    || .  .  .|  |   ||| 
teeryvyqyhftvwpdkgvpqyatavlgl...rrkitkd...slpgarpwvihcsagvgrtgaflvidamlrqakkqktvdifnyvkairedrphmvqts

HQWLYMLL
 |.... |
eqyvfihl
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 20-225 5.4e-30 99.1 In-house 73-229 (392) alignment 
Range on Protein: 20-225
Range on HMM: 73-229/392.0
ASYINGNWMDGFSQSREYIVTQGPLPNTIDAFWRMVWEFKVCQIVMITNLKEKGrvkcekywpfegeqlkigdlillceevklhaafqvaqlrvvhrHTG
  |.|  ....| . . || .||| . ..| |||||....|. |.|.|.|||                                             .  
sdylnasyipsfdnekayiasqgpnaaslddfwrmvfqenvttiamvtklkegd...........................................kgd

VAHTVHHLWFQDWPDHGVPDTTEAVIDLLltsRELRtralASREQVA-PIAVHCSAGIGRSGVFVGCDILLQQAESFGQVDALGALCHMRRARGGCVQTP
 |.||    | .|||..||  | ... ..   .|..    |   | . |. .|||||.||.|| .  | .. .|.    || .  .  .|| |   ||| 
dartvaqfhftewPdkdvpkhtssllkfi...kevk....adfGqythpliihcsagvgrtgvvisidsvvahakktrmvdvfnfvtnirrkrpymvqtk

HQWLYML
 |. .. 
eqyafiy
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 18-233 1.3e-29 98.1 In-house 65-272 (288) alignment 
Range on Protein: 18-233
Range on HMM: 65-272/288.0
SPASYINGNWMDGFSQSREYIVTQGPLPNTIDAFWRMVWEFKVCQIVMITNLKEKGRVKCEKYWPF-EGEQLKIGDLillCEEVKLHAA--FQVAQLRVV
 |  ||. | .      |  | .| ||  ||. .|.|. |  |  |||...| |||. | ..|.|   ||. .|| |   |  || . |   .. .. ..
dpdfyiaanvvssakykrrlicaqaPlngtieelWkmllesdveyivmlcellekGkeksaeyfPsklGekarigrl...ctvvkkkradidklvkvsll

HRHTGVAHT--VHHLWFQDWPDHGVPDTTEAVIDLLLTSrelrtralasREQVAPIAVHCSAGIGRSGVFVGCDILLQQAESFGQVDALGALCHMRRARG
. .  . ..  | .| ...|.|.|||.   . . ||             ..   || ||.|||.||.| ..   | |... .  ..     | ..|  | 
riskegeekvivkilhlleWdddgvPenylsplrllevl..........kslqkPivvhssaGvGrtgtlililialeslrlddflgirsllaklreerf

GCVQTPHQWLYMLLVAHDYLA
 ..||  |.||.  . ...|.
kaiqtemqylyvhrcvleell
subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 20-230 1.1e-28 94.7 In-house 66-267 (281) alignment 
Range on Protein: 20-230
Range on HMM: 66-267/281.0
ASYINGNWMDGFSQSREYIVTQGPLPNTIDAFWRMVWEFKVCQIVMITNLKEKGRVKCEKYWPFEGEQ-LKIGDLILLCEEVKLHAAFQVAQLRVVhrHT
. ||  |..      | ||.||||  .|   ||||.|. .   |||. .. |  | || .|.| .    |..  | .  |.  .  ..  ..| .   . 
tdyihanyirspflkrgyiltqgpkketradfwrmiwqenttaivmlcqfletnrekcaeyfprnahcclqfdklsvsyedstvnkslvttrlnls..ye

GVAHTVHHLWFQDWPDHGVPDTTEAVIDLLltsRELRTRAlasreqvAPIAVHCSAGIGRSGVFVGCDILLQQAES-FGQVDALGALCHMRR-ARGGCVQ
| .. . |  ...|||  ||...| .. .|   |..|.|.       .|  .|||||.|||| ..  .| ||   | |   |    . |.|   |   ||
getrlithwlwkewpdwqvpessevmlkil...rkirars.......tppvihcsagvgrsgtlmaveialqsihshftlpdikqivshlrvtgraasvq

TPHQWLYMLLVAHD
| .|.. .  |  |
tlqqymliwkvlld
subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 20-232 6.2e-28 92.6 In-house 59-270 (285) alignment 
Range on Protein: 20-232
Range on HMM: 59-270/285.0
ASYINGNWMD--GFSQSrEYIVTQGPLPNTIDAFWRMVWEFKVCQIVMITNLKEKGRVKCEKYWPFE-GEQLKIGDLILLCEEVKLHAA--FQVAQLRVV
  ||  .||   |  ||  || ||||||.|.  ||.|... |.. ..|.  | | |  ||  |.| . || .|.|   .   |.|  |     .  | |.
rdyihaswmrmpgkdqs.tyittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekcalyypeklgevvkfgkyeitlteckeeaiagtilnaltvi

HRHTGVAH--TVHHLWFQDWPDHGVPDTTEAVIDLLLTSRELrtralASREqvAPIAVHCSAGIGRSGVFVGCDILLQQAESFGQVDALGALCHMRRARG
      .    . |.    |||.  |. .  .|.|    ...       .|   ||.||||||.||.  ||| |    .     ... |  .  ||  | 
ntedasseplymnhvqvpwwpdqlapedarpmielykwvkkv.....npke..kpicvhcsagvgrtatfvgidyatirimenpniemldivremramrf

GCVQTPHQWLYMLLVAHDYL
 .||.  |.|.. .|  .|.
qavqshmqflflyvvlmeyf
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 16-231 1.7e-26 87.8 In-house 53-258 (267) alignment 
Range on Protein: 16-231
Range on HMM: 53-258/267.0
HPSPASYINGNWMDGFSQSREYIVTQGPLPNTIDAFWRMVWEFKVCQIVMITNLkekGRVKCEKYWPFE-GEQLKIGDLILLCEEVKLHAAFQVAQLRVV
  .   |||  ...|. . . .||||.|| |||  |. .. . ||  ||..|.    .  .  ..|| . |.  |  || .     |    .|.  | . 
rtkeeeyinasyvegyktknafivtqdplkntitdfltvihdqkvpvivlltkv...ftdnirlfwPPkmgqakkyqdltvehslekeendyqiitlelk

HRHtGVAHTVHHLWFQDWPDHgvpDTTEAVIDLLLTSreLRTRALAsrEQVAPIAVHCSAGIGRSGVFVGCDILLQQAESFGQVDALGALCHMRRARGGC
 .    || |   ... |         .  .  |.    |    |   .   |. |.||.|.|||| |.  |  |..|   | .|    | ..|  | | 
fkn.esahnvtlyyykkwnin...tnnkpylkplfgi..laknqle..ngnrPlvvacsdGvGrsGtflvidsqleraktegvsdifdflrkirsqrigl

VQTPHQWLYMLLVAHDY
|.|  ...|.  .  .|
vdtkeryiyihellaey
PTPc_DSPc_SM00012 123-225 3.2e-26 86.9 In-house 1-100 (105) alignment 
Range on Protein: 123-225
Range on HMM: 1-100/105.0
TVHHLWFQDWPDHGVPDTTEAVIDLLLTSRELRTRALAsreqVAPIAVHCSAGIGRSGVFVGCDILLQQAESF-GQVDALGALCHMRRARGGCVQTPHQW
||.|... .|||||||........||   .. .. .       .|. ||||||.||.|.||  |||||| |.  ..|| .  ....|. | |.||| .| 
tvkhyhytgwpdhgvPeesdsilellravkknknkses....skpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqy

LYML
|...
lfly
0048076 (Phosphotyrosine protein) phosphatases II 88-228 2.9e-23 77.6 In-house 11-139 (145) alignment 
Range on Protein: 88-228
Range on HMM: 11-139/145.0
LKIGDLILLCEEVKLHAAFQVAQLRVVHRHTGVAHTVHHLWFQDWPDHGVPDTTEAVIDLLLTSRELRTRalasreQvAPIAVHCSAGIGRSGVFVGCDI
| .|.|   ..   |.     . |.. .  ... ... .... .|||||||| .| ....|   .|.. .         |..||||||.||.|..|....
lylgslptaldlellkdlgittvlnltselellerlgiqylylpwpDhgvpdllellleflefieealke......g.gpvlVHCsaGvgRtgtlvaayl

LLQqaesfGQVDALGALCHMRRARGGCVQTPHQWLYMLLVA
.|.      .|..  || ..|..| |.|..|.|. ..... 
mll.....lgvsleealelvrsqrpgavpnpgqlrflyefe
subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 21-226 3.2e-22 73.5 In-house 80-284 (310) alignment 
Range on Protein: 21-226
Range on HMM: 80-284/310.0
SYINGNWMDGFSQSREYIVTQGPLPNTIDAFWRMVWEFKVCQIVMITNLKEKGRVKCEKYWPFEGEQLKIGD-----LILLCEEV---KLHAAFQVAQLR
 ||  |..        .|..||||  ||  ||||... .   |... .  |.|| ||  |||  |     |      |    ||    .|  .|   .. 
dyihanyvktnylrstficsqgplqhtiidfwrmifqeraesilllckvgeegrpkcvgywpslgvtetygcirvtnlsesseefeicnlavtfvpdnvp

VVHRHTGVAH-TVHHLWFQDWPDHGVPDTTEAVIdllltsrelRTRALAsREQVAPIAVHCSAGIGRSGVFVGCDILLQQAESFGQVDALGALCHMRRAR
|  . . . .  |  . . .||| ||||     .           | || . .  |  ||||||..| .| |  .. .....   .|||     .... |
vdeqpanlkelrvslikwpnwpdrgvpdekchtv.........pqrlla.qvrhgpcvvhcsagkdrlyvvvalklkidkldrglkvdaeevktellksr

GGCVQTPHQWLYMLL
  |.||. |.|..  
aiciqtelqyliidr
subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 32-227 5.6e-22 73.2 In-house 57-254 (290) alignment 
Range on Protein: 32-227
Range on HMM: 57-254/290.0
SQSREYIVTQGPLPN-------TIDAFWRMVWEFKVCQIVMITNLKEKGRV----KCEKYWPF-EGEQLKIGDLILLCEEVKLHAAFQVAQLRVVHrHTG
..  . |.|| |. .       ||  || |. . || |.||. . .|| .      |.|| |  .||.||...| . | .   .  ... .| | .   .
pnglrliltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCakYvpesvgeelkfkgltvkCkskekeddvetRelvvkf.dde

VAHTVHHLWFQDWPDHGVPDTTEAVIDLLltsrelrtRALAsrEQVAPIAVHCSAGIGRSGVFVGCDILLQQA-ESFGQVDALGALCHMRRARGGCVQTP
. .|| | ....| .  |...|  ...|.        . .    . .|. |||  || || ..   ..  |   |. |.|    .|  .|. |  .....
eeftvtHsllkgWnklnvqedtktllsli........qkvk..asktpvivHcvdGiSrsAalaaiilgyQkiaetsgsvkledvlkalrkqralaitsa

HQWLYMLLV
... ... .
lelafvdag
subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 47-231 5.9e-22 73.0 In-house 40-220 (255) alignment 
Range on Protein: 47-231
Range on HMM: 40-220/255.0
TIDAFWRMVWEFKVCQIVMITNLKEKGRVKCEKYWPFEG-EQLKIGDLILLCEEVKLHAAFQVAQLRVVHRHTGVAHTVHHLWFQDWPDHGVPDTTEAVI
|.|.|....   |  ..||.....|.|..||..|.| |  |.||. |. . . .   .  ..  ..     .   .|||.|  .. |...  |. .. . 
tvdkfyqtivqtktevvvmlcdfaeegvekcssyfplekdeklkladvnvtttkssadvvlrtleitstlgekkkthtvkhysykGWieknaPelareil

DLLLTSRElrtralaSReqvaPIAVHCSAGIGRSGVFVGCDILLQ------QAESFGQVDALGALCHMRRARGGCVQTPHQWLYMLLVAHDY
 .|   |.       |.    .. ||||.|||||  ||  ... |      .  . ...| |  | ..|  | . ..|| |  . .|.  |.
nilkvvrd.......sk....svvvhCstGiGrsaafvlaelvyqkmirsldttetveldylslleelrskrkraihtPlqlafsilmvldl
subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 34-217 1.2e-21 71.7 In-house 4-189 (199) alignment 
Range on Protein: 34-217
Range on HMM: 4-189/199.0
SREYIVTQGPLPNTIDAFWRMVWEFKVCQIVMITNLKEKGRVKCEKYWPF-EGEQLKIGDLILLCEEVKLHAAFQVAQLRVVHRHTGVAH--TVHHLWFQ
 | ||.|| || .|.  ||.||||    .|||. . . .  .    |||  |    | | | . .. .  .. . .. | ..   |       . |  | 
qrryiatqhplretmadfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqft

DWPDHGVPDTTeAVIDLLLTSRELRTRAlaSREQVAPIAVHCSAGIGRSGVFVGCDILLQQAE-SF-GQVDALGALCHMRRARGGCVQT
 | ..  |. .   . ....|||.  .    .|. ||. |||| | | .||||  || ..  | |    || .     .|.|| | . .
swkekttpnva.lfvgfvvasrevskky..eqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiiss
subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 34-217 1.4e-21 71.6 In-house 3-188 (198) alignment 
Range on Protein: 34-217
Range on HMM: 3-188/198.0
SREYIVTQGPLPNTIDAFWRMVWEFKVCQIVMITNLKEKGRVKCEKYWPF-EGEQLKIGDLILLCEEVKLHAAFQVAQLRVVHRHTGVAH--TVHHLWFQ
 | ||.|| || .|.  ||.||||    .|||. . . .  .    |||  |    | | | . .. .  .. . .. | ..   |       . |  | 
qrryiatqhplretladfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqft

DWPDHGVPDTTeAVIDLLLTSRELRTRAlaSREQVAPIAVHCSAGIGRSGVFVGCDILLQQAE-SF-GQVDALGALCHMRRARGGCVQT
 | ..  |. .   . ....|||.  .    .|. ||. |||| | | .||||  || ..  | |    || .     .|.|| | . .
swkekttpnva.lfvgfvvasrevskky..eqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiiss
subfamily_CG42327_pd Subfamily CG42327 20-153 1.8e-21 71.1 In-house 56-192 (319) alignment 
Range on Protein: 20-153
Range on HMM: 56-192/319.0
ASYINGNWMDGFSQSR-EYIVTQGPLPNTIDAFWRMVWEFKVCQIVMITNLKEKGRVKCEKYWPFEG---EQLKIGDLILLCEEVKLHAAFQVAQLRVVH
  |.. ... |. ...  || .| .| ..  .|||.||| .   || .|.| |.|  .| .|.| .    ..   ||. .   . . .  . .. | . .
deyldasyvrGyddapnsyiaaqvsledsssdfwrtvweqqsrvivqltdlselGikvcaeylPtketldntslyGdilvtlkgrevkdryaistlllkr

RHTGVAHTVHHLWFqDWPDHGVPDTTEAVIDLLLTSRE
 .   .  . | |. .|.. .||   .|.| .||  |.
vdkeesrelthywy.kwleaevPaeeaaliamllevrs
0048179 (Phosphotyrosine protein) phosphatases II 110-226 1.9e-21 71.7 In-house 48-139 (144) alignment 
Range on Protein: 110-226
Range on HMM: 48-139/144.0
QlrvvhrhtgvahtVHHLWFQDWPDHGVPDTTEAVIDLLLTSRELRTralasrEQvAPIAVHCSAGIGRSGVFVGCDILLqqaesFGQVDALGALCHMRR
.             ...... .|||||||| .| ....|   .|..       |   |..||||||.||.|..| .....       ....  || ..|.
e.............giqylhlpwpDhgvpdllellleflefieeale......eg.gpvlVHCsaGvgRtgtlvaaylmk.....klglsleealalvrs

ARGGCVQTPHQWLYMLL
.| |.|..|.|. ..|.
rrpgavpnpgqlrfLle
subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 15-235 2.4e-21 70.7 In-house 62-279 (312) alignment 
Range on Protein: 15-235
Range on HMM: 62-279/312.0
LHPSPASYINGNWMDGFSQSREYIVTQGPLPNTIDAFWRMVWEFKVCQIVMITNLKEKGRVKCEKYWPFEGEQLKIGDLIL---LCEEVKLHA----AFQ
|      ||  |..   ..   ...||||| ||.  ||...  .  . |.... . | |  || ||       ... |  .    | |...         
lagdenfyihanfvkictkperfvctqgplentcthfwqlalslgstsiillcgfvedgsekcakyisdivgfvdledhrvyteycteieiggkskdkit

VAQLRVVHRHTGVAHTVHHLWFQDWPDHGVPDTTEAVIDLLLtsrelrtralASREQVAPIAVHCSAGIGRSGVFVGCDILLQQAESFGQVDALGALCHM
   |.|| . ||    . |  .  |||||.||. ..   ||           | . .  |.  |||||.||.| ..  . ..       . .   ..  .
hrvlkvvvkatgqesklnhyqwaswpdhgmpdscdtalrlls..........avkkdkkpviahcsagvgrtgtlaliesmiaalrhprkqnvkdsfvll

RRARGGCVQTPHQWLYMLLVAHDYLAKV
|. |   |..  |..| | .  ..|   
rkdrarsvrvfpqyvyalrcvleflysk
subfamily_egg_pd Subfamily egg 21-225 4.3e-21 69.9 In-house 69-263 (307) alignment 
Range on Protein: 21-225
Range on HMM: 69-263/307.0
SYINGNWMDGFSQSREYIVTQGPLPNTIDAFWRMVWEFKVCQIVMITNLKEKgrVKCEKYWPF-EGEQLKI--GDLILLCEEVKLHA--AFQVAQLRVVH
 .|  | ..|     |.|..| || || | |||||.. .|  |||.|  ||    .|| |||  | . |..  | | . . .|. .|   |.|..|..| 
dfihanrvkGkpllnefilaqaplkntvddfwrmvfqeevqyivmltsrkes..erceyywpkaesdslvtvpGslrienlkvdskadplfrvtklklvG

RHTGVAHTVHhlWFQDWPDHGvpdtteaviDLLLTSRELRTralaSREQVAPIAVHCSAGIGRSGVFVGCDILLQQA--ESFGQVDALGALCHMRRARGG
 .    .  |  |  |.   .         |.    | ||      |.   |. |..  |. .....|  .| | .       .   | |   .|. |  
gddeerfleh..wqgdvnnss.........dvysplrvlrk....lrnlskpvvvqdilGvskaatlvaieiallsllrGpitkslvlravvflrlrrrl

CVQTPHQWLYML
 |... ..|.. 
svesvllylfvy
subfamily_hpo-7_pd Subfamily hpo-7 44-231 4.6e-20 66.6 In-house 43-226 (263) alignment 
Range on Protein: 44-231
Range on HMM: 43-226/263.0
LPNTIDAFWRMVWEFKVCQIVMITNLKEKGRVKCEKYWPFEG-EQLKIGDLILLCEEVKLHAAFQVAQLRVVHRHTGVAHTVHHLWFQDWPDHGVPDTTE
| .|||.|....   |  ..||... .|.|..||..|.| |  |..|. .. . . .|.     .  .|  .  .    |||.|  .. |...  |  ..
lvqtidkfyqtivqtktevvvmLcDfneegvekcssyfPlekdekqklanvnvcttkvqsdvllktlellstlgeKkkthtvkhysykgWiekndpelar

AVIDLLLTSRELRtralasreqvaPIAVHCSAGIGRSGVFVGCDILLQ------QAESFGQVDALGALCHMRRARGGCVQTPHQWLYMLLVAHDY
 .. .|   |...           .. ||||.|||||  |.  ... |      .  | ...| |  | ..|  | . ..|| |  . .|.  |.
eilnilkvarnsk...........slvvhcstGiGrsaafsvaElvyqkmirsldttstveldylsLleelrssrkraihtPmqLafsilmvLdf
subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 28-229 3.8e-19 63.3 In-house 83-286 (302) alignment 
Range on Protein: 28-229
Range on HMM: 83-286/302.0
MDGFSQSREYI-VTQGPLPNTIDAFWRMVWEFKVCQIVMITNLKEKGRVKCEKYWPFE-GEQLKIGDLILLCEEVKLH-------AAFQVAQLRV--VHR
|||  . ..   .   |  .|.. .| .. ...|. .| .....|..  || .|.  . |..|| |   .   .|| .        .|.. .. .   ..
mdGtekkekvskkpivpkkstlekhwalieqynvaivvqlcsfvedeekkcaeyysdkvggelkfgrytvktvsvktdleeftdkksfklytveiknekk

HTGVAHTVHHLWFQDWPDHGVPDTTEAVIDLLLTSRELRTRALasreqvapiaVHCSAGIGRSGVFVGCDILLQQAESFGQVDALGALCHMRRARGGCVQ
.. | .||. | |  ||||| |. ... .|.|      ..  |          ||||||.||.| .|     .|        | |  .. .|. | | ||
kkkvkktvdilafsawpdhGapkeaytaldilkfcesykknvl..........vhcsaGvGrtGtlvaikyGiqlcskkkvtdllsivlpvrqcryGavq

TPHQWLYMLLVA-H
. .| .|.||.   
deqqliylllcvtk
subfamily_eak_pd Subfamily eak 18-224 1.6e-16 54.7 In-house 76-299 (332) alignment 
Range on Protein: 18-224
Range on HMM: 76-299/332.0
SPASYINGNWMDGFSQSREYIVTQGPLPNTIDAFWRMVWEFKVCQIVMITNLKEKGRVKCEKYWPFEG-EQLKIGDLILLCEEVKLHAAFQVAQLRVvhR
 .  |||   ..     |.||.|  .  . . |||.|| | |   ||.. .  |..  | .||.| .. |.|| | | . . |   .. ... .| .  .
nrlGyinaslaefsevGrkyiltGiasedkvfafwqmvleqkspaivqlledvelkleksdkyfpdktreelkfGildverkefvkrniletrllel..s

HTGVAHTVHHLWFQDWPDHGVPDTTEA----------VIDLLLTSRELRTRALA-----SREQVAPIaVHCSAGIGRSGVFVGCDILLQQAE----SFGQ
    .| |.|  .  | .  .|   .            . ||.. ..   ...      .    ||| . .. |  |.||||  |.|..  .        
kGnethrvlhykvfGwtettlpkyedflalrkvmkevGvlllivmksallsstlkkyihtppsfapi.iqsarGsaraGvfvvidllirlidnkkknlys

VDALGALCHMRRARGGCVQTPHQWLYM
|. |   .. .|     |.  | ..| 
vedlilkvkskrihsvlvalqhsfiye
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 18-82 1.8e-15 51.5 In-house 81-151 (350) alignment 
Range on Protein: 18-82
Range on HMM: 81-151/350.0
SPASYINGNWMDG--FSQSR----EYIVTQGPLPNTIDAFWRMVWEFKVCQIVMITNLKEKGRVKCEKYWP
|.  ||| |..    ||..      || ||.|||.|.| |.... . ||  |...|.. | .. ||..||.
stnDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvkvilsltsdvelnlekcyrYWq
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 121-224 2e-15 51.1 In-house 88-186 (440) alignment 
Range on Protein: 121-224
Range on HMM: 88-186/440.0
AHTVHHLWFQDWPDHGVPDTTEAVIDLLLTSRELRTRAlasreQVAPIAVHCSAGIGRSGVFVGCDILLQQAESFGQVDALGALCHMRRARGGCVQTPHQ
..|...  .| |||.|||  .  |. ..    | . .|       .|. |||||| ||.|| .  | .|..|.   |.| .  .  ||  |   ||||.|
srtlkqyhyqgwpdkgvpkfagpvlkmiqdvnesqeka.....gngpllvhcsagagrtgviiavdsilreakrsdqidifsfinsmrnnrpqmvqtpeq

WLYM
. ..
yafv
subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 16-220 5.6e-13 43.2 In-house 65-267 (303) alignment 
Range on Protein: 16-220
Range on HMM: 65-267/303.0
HPSPASYINGNWMDGFSQsREYIVTQGPLPNTIDAFWRMVWEFKVCQIVMITNLKEKGRVKCEKYWPFEGEQLKIGDLILLCEEVKLHAAFQVAQLRVVH
. | .|||  ....  |. .  |.|| ||. |   ||.|. | ||  ....    |  ..  .  .| . . ||. .  .   | |     .  .|.|. 
klsdssyihasyleldss.kkailtqlplshtaadfwqmiieqkvkcvlllltdseydklggdsvfprnqdflkfeersirvgefkrvelgdgwvlkvls

RHTGVAHTVHHL-WFQDWPDHGVPDTT--EAVIDLLLTSRELRTralasREQVAPIAVHCSAGIGRSGVFVGCDIL-LQQAESFGQVDALGALCHMRRAR
   |  ..  |.  ...||   .|  .  . | ..      ||        .  |      .| ||.| |   .   |   .    .| .  |  .|  |
vsngdyksflhvhhykawphnsipsdgspkfvkqiwqlqsvlrk.....ysdstptvymslsgcgragtfalfetahlslhseqasldlvkclenvrngr

GGCVQTPHQ
  .||   |
lhavqnlsq
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 122-198 9.3e-13 42.6 In-house 215-295 (350) alignment 
Range on Protein: 122-198
Range on HMM: 215-295/350.0
HTVHHLWFQDWPDHGVPDTTEAVIDLLLTS----RELRTRALASREQVAPIAVHCSAGIGRSGVFVGCDILLQQAESFGQV
. |..| .. |.| ..    | ..  |        .| ..     .. .|| ||||||.|| |..|  | ||.. | . ..
yvvyqlqvknWkDlslllnPesilqalevkndliddlfaeshldnarsspilvhCsaGvGrtGtlvtlDsllsdfeilenl
subfamily_CG42327_pd Subfamily CG42327 160-235 2.1e-12 41.4 In-house 242-318 (319) alignment 
Range on Protein: 160-235
Range on HMM: 242-318/319.0
ASREQVAPIAVHCSAGIGRSGVFVGCDILLQQAESF-GQVDALGALCHMRRARGGCVQTPHQWLYMLLVAHDYLAKV
. ||.  |..|||| |.||.|. .  || ... |     ||    . ..|| |.  |.| .|. ..  |.. | .|.
gtresqGPlvvhcsdGvGrtGlviasdiairsleeskrsvdiPqlvssvrrdrasavltkeqyefiykvlseyakkl
0038934 (Phosphotyrosine protein) phosphatases II 132-229 1.6e-11 39.7 In-house 87-174 (194) alignment 
Range on Protein: 132-229
Range on HMM: 87-174/194.0
WPDHGVPDTTEAVIDLLLTSRELRTRalaSREQvaPIAVHCSAGIGRSGVFVGCDILLQqaesfGQVDALGALCHMRRARGGCVQTPHQWLYMLLVAH
.||.|.. ..| . . |    |   .   . ..   .|||| ||.||.|..|.. ..        . .|  |. ..|..|.|........ ..|   .
fpddgtvPsleillrfldlvdeflne...dpgg..vvaVHCkaGlgRtGtlvaaYLiyr.....lgmsaeeAialfrekRpgaipnqdyleallkryk
subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 19-68 5e-11 36.7 In-house 69-118 (347) alignment 
Range on Protein: 19-68
Range on HMM: 69-118/347.0
PASYINGNWMDGFSQSREYIVTQGPLPNTIDAFWRMVWEFKVCQIVMITN
. .|||   .     |.|||.|| |||.|.  ||.||   || |.| | .
vetyinashikfdnaskeyiltqyplpdtvrdfwkmvsvtkvtqvvtife
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 19-82 5.8e-11 36.3 In-house 89-154 (349) alignment 
Range on Protein: 19-82
Range on HMM: 89-154/349.0
PASYINGNWMD--GFSQSREYIVTQGPLPNTIDAFWRMVWEFKVCQIVMITNLKEKGRVKCEKYWP
.  ||| |..    .|  . || || ||| |.| |....   .|  .. ... ||..  ||..|| 
lddyinanylkltrisvekkyiatqaPlPstvddfykvillngvklvlsLnddkelslekcdiywq
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 28-91 1.4e-10 35.1 In-house 229-289 (440) alignment 
Range on Protein: 28-91
Range on HMM: 229-289/440.0
MDGFSQSREYIVTQGPLPNTIDAFWRMVWEFKVCQIVMITNLKEKgrvKCEKYWPFEGEQLKIG
..|.|.   .| || ||  |.  |||.| ....  |.|. .|..|    |  ||| .   . .|
fegyskknafiatqmpldstvldfwrlvhdyristiimlnqlndk...tcsiywpvntrsvtfg
subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 13-232 2.1e-08 27.9 In-house 68-285 (302) alignment 
Range on Protein: 13-232
Range on HMM: 68-285/302.0
LTLHPSPASYINGNWMDGFSQSREYIVTQGPLPNTI---DAFWRMVWEFKVCQIVMITNLKEKGRvKCEKYWPF-EGEQLKIGDLILLCEEVKLHAAFQ-
. |. .| ||.|.  ..  . .|. |..| |  ..    . |||||.. |. ..|..   .|  .   ....|   |. .. |.. .    |.   . . 
vkleaepdsyvnaskvevPeltrsiilaQlpkvdsedsveeFWrmvfqekivsvvilvgeeelkk.tlselfpkksgdykeygkmfvNnrkVekaeeekt

VAQLRVVHRHTGVAHTVHHLWFQDWPDHGVPDTTEAVIDlllTSRELrtrALASREQVAPIAVHCSAGIGRSGVFVGCDILLQQAESFGQVDALGALCHM
   . |.      .  .    .. |... ||.   ..|    |  ..      . .  .....    |.|| |.|.   . ... ..  .. .   .  .
ryviEvlPegcsnsvlanvyvltnWkqkkvpvkyaelik...taakv...fakkikadentvivSknGaGRagafltlavaveklqkgkepnikeivksi

RRARGGCVQTPHQWLYMLLVAHDYL
|  |   |.. .|.  . ...  |.
RsqRpravdslkQyvslyialllyi
subfamily_PTEN_pd Subfamily PTEN 139-224 3.8e-08 28.5 In-house 89-172 (184) alignment 
Range on Protein: 139-224
Range on HMM: 89-172/184.0
DTTEAVIDLLLTSRELRTRALASrEQVAPIAVHCSAGIGRSGVFVGCdILLQQAESFGQVDALGALCHMRRARGGCVQTPHQWLYM
| . . ..|| .  |  .. |.. ..   ..||| || ||.|| . .  ||..     . .||    ..|   . .|. | |  |.
Dhnppplelleeivediekwlee.dkknvvvvHCkaGkGRtGvliva.yllkslllekaeealelfaeaRtknkkgvtiPsqrRYv
subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 20-82 6.4e-08 26.5 In-house 122-179 (244) alignment 
Range on Protein: 20-82
Range on HMM: 122-179/244.0
ASYINGNWMDGFSQSREYIVTQGPLPNTIDAFWRMVWEFKVCQIVMITNLKEKgrvkcEKYWP
 .|||  ..  . .. |||.|| || .|   ||.|. | .|  .|..  ..|.     ..|||
ntyinasfvgclgrtaeyiltqhpladtsmdfwkmmlerhvnvlvvlgsveee.....deywp
subfamily_Cele-PTP-12_pd Subfamily Cele-PTP-12 21-76 8.6e-08 26.0 In-house 61-117 (332) alignment 
Range on Protein: 21-76
Range on HMM: 61-117/332.0
SYINGNWMDGFSQSREYIVTQGPLPNT-IDAFWRMVWEFKVCQIVMITNLKEKGRVK
 . | .|.||.|.   ||..| |. .     ||||| | |   |... .. || . |
dfynaswvdgyskksayifaqapfndhteyvfwrmvserkpsmilvfgdidekqkrk
subfamily_CDKN3_pd Subfamily CDKN3 90-224 9.7e-08 25.8 In-house 71-188 (202) alignment 
Range on Protein: 90-224
Range on HMM: 71-188/202.0
IGDLILLCEEVKLHaAFQVAQLRVVHRHTGVahTVHHLWFqdwPDHGVPDTTEAvIDLLltsRELRTRALASREQVapiaVHCSAGIGRSGVFVGCdILL
. |...||   .|   ..| .|   ....|.  .|||  .   .| .||| ..  ...|    |||.   | |. .    |||  |.||| . . | .||
vedvfvlctrgels.kyrvrrlldlyqqagl..ivhhypi...adglvpdiasc.lkil...eelrinlkayrktl....vhcygglgrsslviac.lll

QQAESFGQVDALGALCHMRRArgGCVQTPHQWLYM
   . .   ||.  | ... .  . .|| .|. |.
ylddtiepkdaidklrdlkgs..raiqtvkqynyl
subfamily_PTPDC1_pd Subfamily PTPDC1 132-220 1.4e-07 26.1 In-house 90-164 (182) alignment 
Range on Protein: 132-220
Range on HMM: 90-164/182.0
WPDHGVPDtTEAVIDLLltsrELRTRALasREQvaPIAVHCSAGIGRSGVFVGCDILLQQaesfgQVDALGALCHMRRARGGCVQTPHQ
|.|.||.   | ..|.      . . ||  .|.   .|||| || || || . | .. ..     ...|  |.  .|  |  ..|| .|
wkDygvas.leriLdiv....kvvafal..qeg..kvavhChaGlGrtGvliacylvyak.....rltaekaiklvrskrpksiqtreq
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 131-190 1.7e-07 24.9 In-house 227-290 (349) alignment 
Range on Protein: 131-190
Range on HMM: 227-290/349.0
DWPDHGVPDTTEAVIDLLLTSRE----LRTRALASREQVAPIAVHCSAGIGRSGVFVGCDILLQ
.|.| ..     ...  |    .    | .|     .|.... |||||| ||.||.|  |.||.
nwldlslllnPisilqalevkndliddlfarlyldtdqlstllvhcsaGcGrtGvlvtldllls
subfamily_CDC14_pd Subfamily CDC14 167-222 2.7e-07 24.8 In-house 265-316 (328) alignment 
Range on Protein: 167-222
Range on HMM: 265-316/328.0
PIAVHCSAGIGRSGVFVGCDILLQQaesfgQVDALGALCHMRRARGGCVQTPHQ-WL
 ||||| ||.|| | ...| .. .      .. |  |. ..| .| | | .| | .|
aiavhCkaGLGrtGtLiacylmkhy.....rftaaeaiawlricrPGsvigpqqkfl
PTEN_1 146-211 9.4e-07 23.8 In-house 111-174 (196) alignment 
Range on Protein: 146-211
Range on HMM: 111-174/196.0
DLLLTSRELRTRALASREQVAPIAVHCSAGIGRSGVFVGCdILLQQAEsFGQVDALGALCHMRRAR
. |.   .    .| |...   ..||| ||.||||. | .  |..    .   .||  .. .| ..
selfdicksfiewllsdpngnvVlVHCkaGlgRsGtvvaa.yLmykgk.ltadeAlelvrekRppg
subfamily_Sponge-PTP-4_pd Subfamily Sponge-PTP-4 21-82 1.3e-06 22.7 In-house 14-70 (130) alignment 
Range on Protein: 21-82
Range on HMM: 14-70/130.0
SYINGNWMDGFSQSREYIVTQGPLPNTIDAFWRMVWEFKVCQIVMITNLKEKgrvkcEKYWP
 ||| ...    ...||. || || .|   ||.|. |  |  .|..  ..|.     ..|||
tyinasfvGllgrtaeylltqhpladtsmdfwkmmleryvnvlvvlgsveee.....deywp
subfamily_DSP23_pd Subfamily DSP23 163-220 2.9e-06 22.0 In-house 82-134 (148) alignment 
Range on Protein: 163-220
Range on HMM: 82-134/148.0
EQVAPIAVHCSAGIGRSGVFVGCDILLQQaesfgQVDALGALCHMRRARGGCVQTPHQ
|.   ..|||  | ||.| .. | .. ..     .. |  |.  .|| | | |.|  |
ekneavsvhcllgrgrtgtmlacylvker.....klaaaeaiaevrrlrpgsvetveq