Gene MbrePTP-Un-2 in Monosiga brevicollis

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily PTP-unclassified
Protein sequence
ID Type Fasta BLAST phosphatome Note
MbreP055_AA protein Get Run
MbreP055_AA_90-369 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
0050432 (Phosphotyrosine protein) phosphatases II 114-369 1.8e-69 229.8 In-house 61-300 (308) alignment 
Range on Protein: 114-369
Range on HMM: 61-300/308.0
LLIGWPPSLRACSYEDILPFDHNRVKLKCKNDYINASYIKNLL-TGAPDFIASQGPTVPTIRSFWEMIAQYKLSVIVMVTNVLEGDLVKCDPYWPEI--G
    .|     . | ||||.||.||||. ..|||||||..         ||| |||.  |. .|| |. ... .||||.|.  | . .||..|||.   |
svallpenkdkNrykdilpydhsRVkldegsdYInAsyvdgyssklprkfIatqgPlpntvedFwrmvweqnvrvIvmLtklvengrekcaqYwplelgg

QTLSFgsnsefdGSLSVQQLDASDGVAWSRRTFALHY-NDEPERRITQFHYTDWPDQGVPASPHSFVQFVRTVMTSQQRaqasvaaatPPLLVHCSAGVG
..| .       | ..|  |.      . .||. | . .|...|..|.||||.|||.||| || ....|.. | .|..          .| .||||||||
gsley.......gkftvtllseevlddytvrtleltnlgdgesrtvthfhytnWpdhgvPpspeilldflelvrkslpg.........gpivVHCsaGvG

RTGTFIGTYATLCSLHGIrrdkHSIMIPLLVREMRRQRICMVQSLAQYEFLYKSILIAID
||||||  .  |. |.      . . .. .|. .|.|| .|||.. ||.|||. .|  . 
RtGtfialdllleqleke....ggvdvfeavkklReqRpgmvqtpeqylflyralleylk
0051299 (Phosphotyrosine protein) phosphatases II 118-367 3.2e-68 225.6 In-house 46-285 (288) alignment 
Range on Protein: 118-367
Range on HMM: 46-285/288.0
WPPSLRACSYEDILPFDHNRVKLK-----CKNDYINASYIkNLLTGAPDFIASQGPTVPTIRSFWEMIAQYKLSVIVMVTNVLEGDLVKCDPYWPEiGQT
.|  |  . | ||||.||.||||.       .|||||||| ..      ||| |||.  |. .|| |. ... .||||.|.. | . .||..|||. |..
lpenleknRysdilpydhsRVkLsvldgvegsdYinAsyi.dgynlkrkfIatqgPlpntvedFWrmvweqnvrvIvmltklvelgrekcaqYwpl.ggs

LSFGSnsefdgsLSVQQLDASDGVAWSRRTFALHY-----NDEPERRITQFHYTDWPDQGVPASPHSFVQFVRTVMTSQQraqasvaAATPPLLVHCSAG
| .|        ..|  |.      .  ||. . .      |. .|..|.||||.|||.||| || ....|.| |.....       .  .| .||||||
ltygd.......itvtllseevlddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpdspellldflrlvrkala.......sgggpvvVHCsaG

VGRTGTFIGTYATLCSLHgirrDKHSIMIPLLVREMRRQRICMVQSLAQYEFLYKSILIA
||||||||  .  |. |.     .. . .. .|. .|.|| .|||.. ||.|.|. .| .
vgRtgtfialdllleqle....keggvdvleavkrlreqRpgmvqtpeqyrfvyealley
0046845 (Phosphotyrosine protein) phosphatases II 119-370 6.3e-68 224.5 In-house 26-276 (284) alignment 
Range on Protein: 119-370
Range on HMM: 26-276/284.0
PPSLRACSYEDILPFDHNRVKLK------CKNDYINASYIKNLL----TGAPDFIASQGPTVPTIRSFWEMIAQYKLSVIVMVTNVLEGDLVKCDPYWPE
|  |  . | ||||.||.|||||        .|||||||..          . ||| |||.  |. .|| |. ... .||||.|.  | . .||..|||.
penlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweqnvrvIVmltelvengrekcaqYwpl

IGQTLSFgsnsefdGSLSVQQLDASDGVAWSRRTFALHYN--DEPERRITQFHYTDWPDQGVPASPHSFVQFVRTVMTSQQRaqasvAAATPPLLVHCSA
.|..| .       | ..|  |.      . .||. | ..  ....|..|.||||.|||.|||.|| ....|.|.| .....         .| .|||||
egevlty.......gdftvtllseevkddytvrtleltnlgytgesrtvthfhytswpdhgvppspedlleflrlvrellen.....lpgggpivVHCsa

GVGRTGTFIGTYATLCSLHGIRrDKHSIMIPLLVREMRRQRICMVQSLAQYEFLYKSILIAIDE
|||||||||  .  |. |.  . . . . .. .|. .|.|| .|||.|.||.|.|. .| ..  
GvgRtGtfialdllleqlekeg.lllgvdvleavkrlreqRpgmvqtleqyrfvyealleylkl
0040438 (Phosphotyrosine protein) phosphatases II 120-368 3.3e-67 222.3 In-house 42-276 (317) alignment 
Range on Protein: 120-368
Range on HMM: 42-276/317.0
PSLRACSYEDILPFDHNRVKLKC-----KNDYINASYIkNLLTGAPDFIASQGPTVPTIRSFWEMIAQYKLSVIVMVTNVLEGDLVKCDPYWPEiGQTLS
 .   . | ||||.||.||||.       .|||||||. .     . ||| |||.  |. .||.|. .....||||.|.  | . .||..|||. |.|| 
enkdknrypdilpydhsRVkLsplggdldsdYInAsyv.dgpnlkrkfIatqgPlpntvedFwrmvweqgvtvivmLteleelgrekcaqYwpl.getlt

FgsnsefdGSLSVQQLDASDGVAWSRRTFALHY-NDEPERRITQFHYTDWPDQGVPASPHSFVQFVRTVMTSQQraqasvaAATPPLLVHCSAGVGRTGT
.       | ..|. |.      .  ||. . . .|...|..|.||||.|||.||| || ....|.. | ....           |.|||||||||||||
y.......gdftvtllseeelagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfleavreale.......dpggpvlVHCsaGvgRtGt

FIGTYATLCSLhgirRDKHSIMIPLLVREMRRQRICMVQSLAQYEFLYKSILIAI
||. |  |. |    . .. . ..  |.|.|.|| ..||...||.|||. .|  .
fiaaylmleql....ekeggvdveeavkelreqRpgavqtpeqyrflydalleyl
0036941 (Phosphotyrosine protein) phosphatases II 118-368 5.8e-66 218.1 In-house 36-277 (297) alignment 
Range on Protein: 118-368
Range on HMM: 36-277/297.0
WPPSLRACSYEDILPFDHNRVKLkcK-N--DYINASYIkNLLTGAPDFIASQGPTVPTIRSFWEMIAQYKLSVIVMVTNVLEGDLVKCDPYWPEI-GQTL
.|  |  . | ||||.||.||||  . .  |||||||. ..      ||| |||.  |. .|| |. ... .||||.|.. | . .||..|||.  |..|
lpenleknRykdilpydhtRVkl..ddegsdYinAsyv.dgydlkrkfIatqgPlpntvedFWrmvweqnvtvIvmltelvelgrekcaqywpleegesl

SFgsnsefdGSLSVQQLDASD--GVAWSRRTFALHY-NDEPERRITQFHYTDWPDQGVPASPHSFVQFVRTVMTSQQRAqasvaAATPPLLVHCSAGVGR
 .       | ..|. |. .      . .||. . . .....|..|.||||.||| ||| || |...|.. | . .. .        .| ||||||||||
ty.......gdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfielvrkvlkll.....psggpvlVHCsaGvgR

TGTFIGTYATLCSLHGIrRDKHSIMIPLLVREMRRQRICMVQSLAQYEFLYKSILIAI
.||||. .  |. |..  .  . . |. .|...|.|| ..||.| ||.|||  .|  .
sgtfiaadlmlqqledk.lkeggvdileavkklReqRpgavqtleqyrflyeallell
DSPc_SM00195 127-366 6.8e-65 214.4 In-house 32-260 (263) alignment 
Range on Protein: 127-366
Range on HMM: 32-260/263.0
YEDILPFDHNRVKLKCK-----NDYINASYIKNLlTGAPDFIASQGPTVPTIRSFWEMIAQYKLSVIVMVTNVLEGDLVKCDPYWPEIGqtlsfGSNSEF
|..|||.||.||||| .     .|||||.|||   .   ..|| |||.  |...||.|. . | ..|||.|.  | .  ||| ||||       |....|
yknilpydhtrVklkkeekkegsdYINAnyikga.nkkkkyIatQgPlpstvedFWrmvweekvkiivmlteeeengkekcdrywpees.....ggketf

DgSLSVQQLDASDGV-AWSRRTFALHYND-EPERRITQFHYTDWPDQGVPASPHSFVQFVRTVMTSQQRAqasvaaaTPPLLVHCSAGVGRTGTFIGTYA
. ..||.  .       . .||. | ... | .|..||..|..|||.||| |..|.....|.| .|...        ..|..|||||||||||||. .  
g.kisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkksksts.......sgpivVhCsaGvgRtgtfvtidi

TLCSLHGIRRdkhsIMIPLLVREMRRQRICMVQSLAQYEFLYKSILI
 | .|.   .    . |  .|.|.| ||. |||.|.|| |.|. || 
ilskleeekk....vdifeivkelRkqRpgmvqtleqYlfiyeaile
PTPc_SM00194 127-366 6.8e-65 214.4 In-house 32-260 (263) alignment 
Range on Protein: 127-366
Range on HMM: 32-260/263.0
YEDILPFDHNRVKLKCK-----NDYINASYIKNLlTGAPDFIASQGPTVPTIRSFWEMIAQYKLSVIVMVTNVLEGDLVKCDPYWPEIGqtlsfGSNSEF
|..|||.||.||||| .     .|||||.|||   .   ..|| |||.  |...||.|. . | ..|||.|.  | .  ||| ||||       |....|
yknilpydhtrVklkkeekkegsdYINAnyikga.nkkkkyIatQgPlpstvedFWrmvweekvkiivmlteeeengkekcdrywpees.....ggketf

DgSLSVQQLDASDGV-AWSRRTFALHYND-EPERRITQFHYTDWPDQGVPASPHSFVQFVRTVMTSQQRAqasvaaaTPPLLVHCSAGVGRTGTFIGTYA
. ..||.  .       . .||. | ... | .|..||..|..|||.||| |..|.....|.| .|...        ..|..|||||||||||||. .  
g.kisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkksksts.......sgpivVhCsaGvgRtgtfvtidi

TLCSLHGIRRdkhsIMIPLLVREMRRQRICMVQSLAQYEFLYKSILI
 | .|.   .    . |  .|.|.| ||. |||.|.|| |.|. || 
ilskleeekk....vdifeivkelRkqRpgmvqtleqYlfiyeaile
0047943 (Phosphotyrosine protein) phosphatases II 116-366 7.7e-65 214.4 In-house 33-270 (273) alignment 
Range on Protein: 116-366
Range on HMM: 33-270/273.0
IGWPPSLRACSYEDILPFDHNRVKL-KCKNDYINASYIkNLLTGAPDFIASQGPTVPTIRSFWEMIAQYKLSVIVMVTNVLEGDLVKCDPYWPEIGQ--T
  .|  .  . | ||||.||.||||   ..|||||||. ..    . ||| |||.  |. .|| |. ... .||||.|.. | . .||..|||. |.  .
allpenkdknrykdilpydhsrvklgdggsdyinAsyv.dgynlkrkfiatqgPlpntvedfwrmvweqnvrviVmLtelvelgrekcaqYwpleggels

LSFGSnsefdgsLSVQQLDASDGVAWSRRTFALHY-NDEPERRITQFHYTDWPDQGVPASPHSFVQFVRTVMTSQQRAQASvaaatPPLLVHCSAGVGRT
| .|        ..|  |.      .  ||. | . ... .| .|.||||.|||.|||.|. |...|.. |.. .. .  .     .| .||||||||||
ltygk.......ftvtllseetkddytvrtleltnlgtgesrtvthfhytgwpdhgvppslesllefielvrkalealpsn.....gpvvVHCsaGvgRt

GTFIGTYATLCSLhgirRDKHSIMIPLLVREMRRQRICMVQSLAQYEFLYKSILI
||||  .  |. |    . .. . .. .|. .|.|| .|||.. ||.|||. .| 
gtfialdllldql....ekeggvdvleavkllrsqRpgmvqtpeqyrflyealle
Y_phosphatase Protein-tyrosine phosphatase 125-365 1e-64 213.5 Pfam-A 5-234 (235) alignment 
Range on Protein: 125-365
Range on HMM: 5-234/235.0
CSYEDILPFDHNRVKL--KCK-NDYINASYIKNLLtGAPDFIASQGPTVPTIRSFWEMIAQYKLSVIVMVTNVLEGDLVKCDPYWP-EIGQTLSFGSnse
. |.||||.|..||||  ... .|||||.|.|.       |||.|||.  || .||.|. |.| .||||.|.. | . .||..||| | ...|..|.   
nRykdilpydktrvklkgsegpsdYInAnyvkgyk.ekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeesltygd...

fdgsLSVQQL-DAS-DGVAWSRRTFALHYNDEPE--RRITQFHYTDWPDQGVPASPHSFVQFVRTVMTSQqraqasvAAATPPLLVHCSAGVGRTGTFIG
    ..|.   . . |  ..  |.. |. ..|..  |...|.|||.|||.|||.||.|.....| | .|.       .| . |..|||||||||||||. 
....ikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkveksk.......eaksgpvvVhCsaGvgRtgtfva

TYATLCSLHGirrD-KhsIMIPLLVREMRRQRICMVQSLAQYEFLYKSIL
  . |..|.    . .  . .  .|.|.|.||. |||||.||.|||| ||
ldilleqlea...eee..vdvlqivkelRkqRpgmvqsleqYiflykail
Y_phosphatase Protein-tyrosine phosphatase 125-365 1e-64 213.5 In-house 5-234 (235) alignment 
Range on Protein: 125-365
Range on HMM: 5-234/235.0
CSYEDILPFDHNRVKL--KCK-NDYINASYIKNLLtGAPDFIASQGPTVPTIRSFWEMIAQYKLSVIVMVTNVLEGDLVKCDPYWP-EIGQTLSFGSnse
. |.||||.|..||||  ... .|||||.|.|.       |||.|||.  || .||.|. |.| .||||.|.. | . .||..||| | ...|..|.   
nRykdilpydktrvklkgsegpsdYInAnyvkgyk.ekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeesltygd...

fdgsLSVQQL-DAS-DGVAWSRRTFALHYNDEPE--RRITQFHYTDWPDQGVPASPHSFVQFVRTVMTSQqraqasvAAATPPLLVHCSAGVGRTGTFIG
    ..|.   . . |  ..  |.. |. ..|..  |...|.|||.|||.|||.||.|.....| | .|.       .| . |..|||||||||||||. 
....ikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkveksk.......eaksgpvvVhCsaGvgRtgtfva

TYATLCSLHGirrD-KhsIMIPLLVREMRRQRICMVQSLAQYEFLYKSIL
  . |..|.    . .  . .  .|.|.|.||. |||||.||.|||| ||
ldilleqlea...eee..vdvlqivkelRkqRpgmvqsleqYiflykail
0045450 (Phosphotyrosine protein) phosphatases II 91-365 6.7e-64 211.9 In-house 24-301 (307) alignment 
Range on Protein: 91-365
Range on HMM: 24-301/307.0
RSAKRLWREIDSSVAFSTR-WCATLLIGWPPSLRACSYEDILPFDHNRVKLKC------KNDYINASYIKNLLT-------GAPDFIASQGPTVPTIRSF
 .  .|..|. . . . .. .. .    .| .   . | ||||.||.||||.        .|||||||..  |.           ||| |||.  |. .|
dfltgllkefekllsvtvfllgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydlkrkfIatqgPlpetvedF

WEMIAQYKLSVIVMVTNVLEGDLVKCDPYWPEIGQTLSFGSnsefdgsLSVQQLDASDGVAWSRRTFALHY--NDEPERRITQFHYTDWPDQGVPASPHS
|.|. ... .||||.|.  | . .||..|||. |..| .|        . |  |. .    . .||. ...   ....|..|.||||.|||.||| |. .
wrmlweqgvtvivmltelvelgrekcaqywPdegeeltygn.......ftvtllseehldgytvrtlevtdldgtgesrtvthfhytgwpdhgvppsfee

FVQFVRTVMTSQQRAqasvaAATPPLLVHCSAGVGRTGTFIGTYATLCSL--------HGirrdkhsimIPLLVREMRRQRICMVQSLAQYEFLYKSIL
...|.. |.. ...          | |||||||||||||||. |  |. |                   ..  |...|.|| ..||.. ||.|||. .|
lldfieevrkaleel.....pkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvd.........lleavkllreqRpgavqnpeqyrflyeall
subfamily_PTPN23_pd Subfamily PTPN23 126-372 2e-63 208.9 In-house 48-284 (288) alignment 
Range on Protein: 126-372
Range on HMM: 48-284/288.0
SYEDILPFDHNRVKLK-CKNDYINASYIKNLLTGAPDFIASQGPTVPTIRSFWEMIAQYKLSVIVMVTNVLEGDLVKCDPYWPE-IGQTLSFGSnsefdg
 ..||||.|||||||.  |.||||||..|.| .|.|||||.|.|  .|.  || |. . | |||||...  | .  |.| ||||  |.| .||       
rsrdilPyDhnRvklrgskDDYinAsfvkdlspgcPdfiatqaPlqstlnDFWlmvyeqkssviVmllskeelgkpkvdrYwPedkgetvkfgd......

sLSVQQLDASDGVAWSRRTFALHYNDEP-ERRITQFHYTDWPDQGVPASPHSFVQFVRTVMTSQQRAQASVAAatpPLLVHCSAGVGRTGTFIGTYATLC
 |||   .  .   ...|.. |. .|.   . ..  ..| ||. ||||||....||.  | .. .  |  . .   ||.|||||||||||.|   || . 
.lsvtlksvretethvervlkletldadavksvshlqltsWpelGvPasPetllqfldevesayeavqrkskt...PlvvhCsaGvgRtgvfalvyaavr

SLhgiRRDKHSIMIPLLVREMRRQRICMVQSLAQYEFLYKSILIAIDEYM
 |   ....  . |. .|. .|.||  |||  .|..|.|. .| |. ...
el...ekgnglldiiqvvsrlreqRrfmvqekeqlkfsyeavleaarrvl
subfamily_PTPRD_pd Subfamily PTPRD 127-375 2.2e-63 209.8 In-house 54-288 (564) alignment 
Range on Protein: 127-375
Range on HMM: 54-288/564.0
YEDILPFDHNRVKLK-----CKNDYINASYIKNLLtGAPDFIASQGPTVPTIRSFWEMIAQYKLSVIVMVTNVLEGDLVKCDPYWPEIGqTLSFgsnsef
|..|...||.||.|.      . ||||||.|.        .||.|||. .||. || |. ... |.|||.|.. | . |||. |||| | | ..      
yanivaYdhsRVvLskvegdegsDYINAsfidgyr.krkayIAtqgPlaetiedFWRmvweqnsstiVmltkleEkgkvkchkYWPekg.tety......

dGSLSVQQLDASDGVAWSRRTFALHYNDE-PERRITQFHYTDWPDQGVPASPHSFVQFVRTVMTSQQraqasvaAATPPLLVHCSAGVGRTGTFIGTYAT
 |.| |.  .  .    . ||| |. ...   | ..|||.|.|||.||| |. |.....|.| ....         . |..||||||||||||||   | 
.geltVtleeeeeladyeirtfklkkkkssesreVrqFhFtsWPdhgvpesatslLdlirkvralne.......pdagPivVhCSaGVGRTGtfividam

LcslHGIRRdKHSIMIPLLVREMRRQRICMVQSLAQYEFLYKSILIAIDEYMRSA
|     |.  .. . |   |...|.||  |||.  || |... || |.. .  . 
l...erike.ektvDiyqyvkalrkqRnamVqteeQYiFiheailealacgntev
0039614 (Phosphotyrosine protein) phosphatases II 119-369 2.3e-63 209.7 In-house 54-290 (297) alignment 
Range on Protein: 119-369
Range on HMM: 54-290/297.0
PPSLRACSYEDILPFDHNRVKLKCKND------YINASYIKNLLTGAPDFIASQGPTVPTIRSFWEMIAQYKLSVIVMVTNVLEGDLvKCDPYWPEIGQt
| .   . | ||||.||.||||| ...      ||||||..      ..|||.|||.  |. .||.|. ... .||||.|.  | .  ||..|||| |. 
penkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfIatqgPlpetvedFwrmvweqgvtvivmLtklvelgr.kcaqywpeegg.

lsfgsnseFDGSLSVQQLDASDGVAWSRRTFALHYNDEPeRRITQFHYTDWPDQGVPASPHSFVQFVRTVMTSQQRAqasvaAATPPLLVHCSAGVGRTG
          | ..|  |.      . .||. . .|.|. | .|.|.||.||| ||| |. .. .|.. |.. ....         | ||||||||||||
........tygdftvtllkvehldgytvrtlevtnnges.rtvthfqytgwpdhgvppslellleflelvrealael.....pkggpvlVHCsaGvgRtG

TFIGTYATLCSLhgirRDKHSIMIPLLVREMRRQRICMVQSLAQYEFLYKSILIAID
|||. |  |. |    . .. . ..  |.|.|.|| ..||.. ||.|||. .|  . 
tfiaaylmleql....ekeggvdvleavkelreqRpgavqtpsqyrflydallellk
0043336 (Phosphotyrosine protein) phosphatases II 117-365 3.2e-63 209.1 In-house 41-274 (278) alignment 
Range on Protein: 117-365
Range on HMM: 41-274/278.0
GWPPSLRACSYEDILPFDHNRVKLKC-----KNDYINASYIkNLLTGAPDFIASQGPTVPTIRSFWEMIAQYKLSVIVMVTNVLEGDLVKCDPYWPeiGQ
 .| .   . | ||||.||.||||.       .|||||||. ..    ..|||.|||.  |.  ||.|. ... ..|||.|.  | . |||..|||  |.
llpenkdknrykdilpydhsrvklsllggdldsdYinAsyv.dgynvprkfiatqgPlpetvedFwrmvwelgvttivmLtelvelgrvkcaqYwp..gg

TLSFGSnsefdgsLSVQQLDASDGVAWSRRTFALHY-NDEPERRITQFHYTDWPDQGVPASPHSFVQFVRTVMTSQQraqasvaAATPPLLVHCSAGVGR
.| .|        ..|  |.      . .||. ...  | ..| .|..||..|||.||| |. ....|...|.. ..           |.||||||||||
sltygd.......ftvtllkeehlddytvrtlevtnlgdgesrtvthyhylgwpdhgvpeslsllldflkavreale.......dsngpvlVHCsaGvgR

TGTFIGTYATLCSLhgirRDKHSIMIPLLVREMRRQRICMVQSLAQYEFLYKSIL
|||||. |  |. |    .. . . ..  |.|.|.|| ..||.. ||.|||. .|
TGtfialyllleql....ekeggvdleeavkelreqRpgavqtpsqyrflyeall
subfamily_PTPRB_pd Subfamily PTPRB 126-369 1.3e-62 206.5 In-house 56-286 (293) alignment 
Range on Protein: 126-369
Range on HMM: 56-286/293.0
SYEDILPFDHNRVKL-----KCKNDYINASYIKNLlTGAPDFIASQGPTVPTIRSFWEMIAQYKLSVIVMVTNVLEGDLVKCDPYWPEIgqtlsfgSNSE
 |..|||.||.||||     . ..|||||.||... .   .|||.|||   |.  ||.|. . | |.|||.|...|.  |||. |||.        ... 
rytnilpydhsrvkLaalkdesgsDYinanyipgy.nsprefiatqGPlpetvddfWrmvwekkssiivmltqlvekgkvkCeeYWPad.......eepv

FDGSLSVQQLDASDGVAWSRRTFALHYNDEpERRITQFHYTDWPDQGVPASPHSFVQFVRTVMTSQQRaqasvAAATPPLLVHCSAGVGRTGTFIGTYAT
. |...|. .  ..   |  |..... ..| ||...|.|.| ||| ||| .......||||| .....     .|.. |..||||||||||||||     
lyGdikvtlvaeeeledwvirelkiekeke.erkvrqyhftsWpdhgvPektktlldfvrtvreaiek.....taskrPivvhCsaGvGRtGtfialdrl

LCSLHGirrdKHSIMIPLLVREMRRQRICMVQSLAQYEFLYKSILIAID
| ...     .  . |  .| |.|..| ..||. .|| |.....|  . 
lqaiee....edyvdifgivaelReeRnllvqtekqYifihqcvldllr
0045098 (Phosphotyrosine protein) phosphatases II 121-366 2.2e-62 206.3 In-house 33-270 (278) alignment 
Range on Protein: 121-366
Range on HMM: 33-270/278.0
SLRACSYEDILPFDHNRVKlkcknDYINASYIKNLltGaPDFIASQGPTVPTIRSFWEMIAQYKLSVIVMVTNVLEGDLVKCDPYWPEiGQTLSFgsnse
.|  . | ||||.||.|||     ||||||||.    . . ||| |||.  |. .||.|. ... .||||.|...|.. .||..|||| |..| .     
nldknRykdilpydhsrVk.....dYINAsyidgy..p.kkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrekcaqywpe.ggslty.....

fdGSLSVQQLDASDGVAWSRRTFALHY-----NDEPERRITQFHYTDWPDQGVPASP--HSFVQFVRTVMTSQQRAQASVAA------ATPPLLVHCSAG
  | ..|  |. .    .  ||. ...     .| ..| .|..||. ||| ||| .|   || .... .   .....  .           | |||||||
..gdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsggpvlVHCsaG

VGRTGTFIGTYATLCSLhgirrdKHSIMIPLLVREMRRQRIC-MVQSLAQYEFLYKSILI
||||||... |  |. |      .. . ..  |.|.|.|| . .||.| ||.|||. .| 
vgRtGtlvaaylmlell......eggvdlleavkelrsqRpglavqnleqyrflyeflle
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 126-372 2.1e-61 202.5 In-house 46-280 (281) alignment 
Range on Protein: 126-372
Range on HMM: 46-280/281.0
SYEDILPFDHNRVKL-----KCKNDYINASYIKNlLTGAPDFIASQGPTVPTIRSFWEMIAQYKLSVIVMVTNVLEGDLVKCDPYWPEIGQtlsfgsnSE
 | .|  .|. |||.     . ..|||||....  ..|  ..||.|||   .. .||.|. ..| |.|||||. .|.. .||  |||.  .       . 
rYsnivaYDatrvkvtpneenkntDYinanfvpg.ykgekeyiatqgPvPaslvafWqmvweqkvsaivmvtreieagklkChrYWPddns.......el

FDGSLSVQQLDASDGVAWSRRTFALHYNDEPERRITQFHYTDWPDQGVPASPHSFVQFVRTVMTSQQRAQAsvaaatPPLLVHCSAGVGRTGTFIGTYAT
  | . |... ...   . .|.| |. .. ..|...|..|| |||.||||... ...| . |.  ... .        ||..|||||||||||.|.    
kygdvtvkstaeeekatyierkfkleresgetreveqlaytaWPdhGvPattkellefrkevlkltekktk......aplvihCsaGvGrtGtyialDrl

LcslHGIRRDKHSIMIPLLVREMRRQRICMVQSLAQYEFLYKSILIAIDEYM
.   . . ...... .  .|.|.|..|  |||...||||.|| .| |.|...
v...kaveaeleeldvkavvaelrkernlmvqtvvqyefvykavldaldkel
0040439 (Phosphotyrosine protein) phosphatases II 119-365 5.3e-61 201.7 In-house 9-243 (249) alignment 
Range on Protein: 119-365
Range on HMM: 9-243/249.0
PPSLRACSYEDILPFDHNRVKLKC-----KNDYINASYIkNLLTGAPDFIASQGPTVPTIRSFWEMIAQYKLSVIVMVTNVLEGDLVKCDPYWPEiGQTL
| ..  . | ||||.||.||||.       .|||||||| ..    ..||| |||.  |. .||.|. ... .||||.|.  | . .||..|||. |..|
penkdknrypdilpydhsrvklsilpglflsdyinAsyi.dgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywpl.ggsl

SFgsnsefdGSLSVQQLDASDGVAWSRRTFALHY-NDEPERRITQFHYTDWPDQGVPASPHSFVQFVRTVMTSQQRAqasvaAATPPLLVHCSAGVGRTG
 .       | ..|. |.      . .||. |..  | ..|......||||||.||| |. ....|.. |.. ....         |.||||||||||||
ey.......gdftvtllsvevkddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleel.....pkggpvlVHCsaGvgRtG

TFIGTYATLCSLHgirrDKHSIMIPLLVREMRRQRICMVQSLAQYEFLYKSIL
|||. |  |. |.     .. . ..  |...|.|| ..||.. ||.|||. .|
tfiaaylmleqle....kelgvdleeavkllrsqRpgavqnpeqyrflyeall
0042113 (Phosphotyrosine protein) phosphatases II 121-365 2.8e-60 199.1 In-house 9-240 (245) alignment 
Range on Protein: 121-365
Range on HMM: 9-240/245.0
SLRACSYEDILPFDHNRVKLKCK-----NDYINASYIkNLLTGAPDFIASQGPTVPTIRSFWEMIAQYKLSVIVMVTNVLEGDLVKCDPYWPEiGQTLSF
.   . |.||||.||.||||.       .|||||||. ..    | |||.|||.  |.  ||.|. ......|||.|.  | . |||..|||. |..| .
nkdknrysdilpydhtrvklspdggdldsdyinasyv.dgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywpl.geslty

GSnsefdgsLSVQQLDASDGVAWSRRTFALHY-NDEPERRITQFHYTDWPDQGVPASPHSFVQFVRTVMTSQQRaqasvaAATPPLLVHCSAGVGRTGTF
|        ..|. |.      . .||. ...  | ..| ....||..|||.||| .. ....|.. | . ...       .  |.||||||||||||||
gd.......ftvtllseehlddytvrtlevtnlgddesrevihyhylpwpdhgvpdllellldflefvrkalae......dsngpvlVHCsaGvgRtGtf

IGTYATLCSLhgirRDKHSIMIPLLVREMRRQRICMVQSLAQYEFLYKSIL
|. |  |. |    .  . . ..  |.|.|.|| ..||.. ||.|||. .|
iaaylmleql....ekelgvsleeavkelrsqRpgavqtpsqyrflyeall
0037934 (Phosphotyrosine protein) phosphatases II 121-365 4.3e-60 198.6 In-house 10-239 (243) alignment 
Range on Protein: 121-365
Range on HMM: 10-239/243.0
SLRACSYEDILPFDHNRVKLKCkNDYINASYIKNLltgaPDFIASQGPTVPTIRS----FWEMIAQYKLSVIVMVTNVLEGDLVKCDPYWPeigqtlsfg
.|  . | ||||.||.||||.  .|||||..|. .    | .||.|||.  |. .    ||.|. ... .||||.|.  | . .||..|||         
nlsknrysdilpydhsrvkleg.sdyinanliyvt....prliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywp.........

sNSEFDGSLSVQQLDASDGVAWSRRTFALHY--NDEPERRITQFHYTDWPDQGVPASPHSFVQFVRTVMTSQQR-AQASVAAATPPLLVHCSAGVGRTGT
 ...  | ..|. |. . .  .  ||. | .   |...| ....||. |||.||| || ....|.. | . ...  .. ..    |.|||||||||||||
.gevtygdftvtllseehlddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRtGt

FIGTYATLCSLhgirrdkhSIMIPLLVREMRRQRIC-MVQSLAQYEFLYKSIL
.|  |  |  |        .. .   |...|.|| . .||.. ||.|||. .|
liaaylmllll........gvdleeavkllreqRpgkavqtpsqyrflyeall
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 127-370 5.5e-60 197.9 In-house 53-281 (288) alignment 
Range on Protein: 127-370
Range on HMM: 53-281/288.0
YEDILPFDHNRVKLKC-----KNDYINASYIKNLlTGAPDFIASQGPTVPTIRSFWEMIAQYKLSVIVMVTNVLEGDLVKCDPYWPEIGQTLSFGsnsef
|..|||.|..|||||      ..||||||||..   .   .||.|||   |.  |||.. ..| | |||.|...||.  ||. |||. ..   .|     
yrnilpyDekrvklkkleeeagaDYinasyidge.kkkkkyiatqgPladtvndfWelvyenktstivmltelveggktkCeeYWPdadkpknyG.....

dgSLSVQQLDASDGVAWSRRTFALHyNDEPERRITQFHYTDWPDQGVPASPHSFVQFVRTVMTSQQRAqasvaaaTPPLLVHCSAGVGRTGTFIgtyATL
  |. |. ..  .   .  |.. |.  .. |..|||..|. |||.|||.| . .....|.| ...|         | |..||||||||||||||   |  
..svtvtlveskeledfvlrkllle.kkkteleitqyqylaWpdhgvPeskapllellrqvkvanqad.......tgpiivhCsaGvGrtgtFi...ald

CSLHGIRRdKHSIMIPLLVREMRRQRICMVQSLAQYEFLYKSILIAIDE
. .. ... .  | .   | ..|.||  .|| | ||||.|. .|  |.|
alidavee.edyiDvagtvaklRkqRallvqtlkqYefiyevllsliee
subfamily_PTPN6_pd Subfamily PTPN6 127-370 1.5e-58 193.2 In-house 60-299 (306) alignment 
Range on Protein: 127-370
Range on HMM: 60-299/306.0
YEDILPFDHNRVKL----KCKNDYINASYIKN-LLTGAPDFIASQGPTVPTIRSFWEMIAQYKLSVIVMVTNVLEGDLVKCDPYWPEIGQTlsfgsnSEf
|. ||||||.||.|       .|||||.|||. . .    .||.||    |.  ||.|. | .  ||||.|. .|    || .|||.  ..      .| 
yknilPfDhtrvilkepsvpgsdyinanyikkevkgsdksyiatqgclettvsdFWrmvwqensrvivmttkevErgkekCarYWPdeeek......ee.

DGSLSVQQLDASDGVAWSRRTFALH--YNDEPERRITQFHYTDWPDQGVPASPHSFVQFVRTVMTSQQRAQASvaaATPPLLVHCSAGVGRTGTFIGTYA
 |..||.... ..  ..  |.. ..   ... ||.. |.|...|||.|||..|  ...|...| . |.. ...    . |..||||||.||||||| . .
yGkisvtnvseksladYilRelsvskkkkkkeerevfqyhfksWPdhgvpkdpgavLdfledvnrkqeeleea...eagpivvhCsaGiGRtGtfiviDi

TLcSLHGIRRDKHSIMIPLLVREMRRQRICMVQSLAQYEFLYKSILIAIDE
 | .|   .  .  | |  ||. .|.||  .||  .|| |.||.|   |..
ll.kliekkgldadidiqklvksvreqrsglvqteqqykfvykaikkyiet
subfamily_PTPN12_pd Subfamily PTPN12 125-374 3.1e-58 192.0 In-house 44-283 (290) alignment 
Range on Protein: 125-374
Range on HMM: 44-283/290.0
CSYEDILPFDHNRVKLKCK-----NDYINASYIKNlLTGAPDFIASQGPTVPTIRSFWEMIAQYKLSVIVMVTNVLEGDLVKCDPYWPEIGQT-LSFGsn
  | ||||.|..||.|. .     .|||||..||.  .|   .||.|||   |.  || || .......||. ...| .  ||. |||| |.. | ||  
nrykDilPydksrvelskieeeegsdYinanfikg.vegkleyiaaqgPLpktlddfWrmiweknveivvmaCrevelgkkkCerYWpeegeeelefg..

sEFDGSLSVQQLDASDgvaWSRRTFALHYNdEPERRITQFHYTDWPDQGVPASPHSFVQFVRTVMTSQQraqasvaAATPPLLVHCSAGVGRTGTFIGTY
 ||  .|. ..    |   .  ||.... . . .|...|||||.|||.|||.|..| ......| . |.       .   ||.|||||||||||| |   
.efevtleeekavddd...flirtLkveaq.kesrkvyqfhYtaWPDhgvPssaksllelielvrelqe.......sedaPlvvhCsaGvGrtGtiiaid

ATLCSLHGiRRDKHSIMIPLLVREMRRQRICMVQSLAQYEFLYKSILIAIDEYMRS
 .   |.  .. .... .  ||.|.|.|| ..||.  |||..||...  . . ...
yvrellka.ekipeeldvfdlvlelrkqraalvqtkeqyelvykavaelvqkelei
subfamily_PTPN3_pd Subfamily PTPN3 125-370 2.9e-56 185.5 In-house 45-277 (280) alignment 
Range on Protein: 125-370
Range on HMM: 45-277/280.0
CSYEDILPFDHNRVKLKCKN-DYINASYIKNLLTG---APDFIASQGPTVPTIRSFWEMIAQYKLSVIVMVTNVLEGDLVKCDPYWPEIGQTLSFGsnsE
  | ||||.|. |||||  . |||||.|..  . .      .||.|||   |   ||.|. . | |.|||.|...|   |||  |||| ...|..|   |
nryrdilpydatrvklkesetdyinanyvnmeipstglvnryiatqGPlaktatdfWqmvweqksslivmlttlverGrvkChqyWPetedeleyg...e

FdgslSVQQLDASDGVAWSRRTFALHYND-EPERRITQFHYTDWPDQGVPASPHSFVQFVRTVMTSQqraqasvAAATPPLLVHCSAGVGRTGTFIGTYA
|    ||.    .   ..  | . |. .. . ||.|.|. |..|||.||| ....|..||..| . .       .... |..||||||.|||| .|    
f....svkcekedetksyvlrelvlkdketkeerkilqlqylaWpdhgvPddsadflefvervrklr.......sgkeePvvvhCsaGigrtGvlillet

TLCslhgIRRDKHSIMIPLLVREMRRQRICMVQSLAQYEFLYKSILIAIDE
.|.    .   .... .. .||.|| || ..||. .||.|. ..|| . .|
ala....lieaaepvypldivrtmrdqramlvqtasqykfvCeailkvyee
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 127-369 8.8e-55 181.0 In-house 62-291 (298) alignment 
Range on Protein: 127-369
Range on HMM: 62-291/298.0
YEDILPFDHNRVKLKC-----KNDYINASYIKNLlTGAPDFIASQGPTVPTIRSFWEMIAQYKLSVIVMVTNVLEGDLVKCDPYWPEIGQTlsfgsnseF
| ||...|. || |.      . ||||||....  .| . |||.|.| ..|.  || |. ... ..|||.||. | | .|.  |||. |..         
yadiialdssRvvLekedadeesdYiNAsflhay.kgrnafiatqaPltetvedFWrmvteedigtiVmltnleeldktkyhkywPdegke........t

DGSLSVQQLDASDGVAWSRRTFALHY-NDEPERRITQFHYTDWPDQGVPASPHSFVQFVRTVMTSQQRAQASvaaatpPLLVHCSAGVGRTGTFIGTYAT
 |...|. |   .      |.....  . | ||.. |.|.| |||.|||.  .| ....| | .|||.|  .      |..|.|||||||.||||  .. 
ygeitvsllskeefadlivrklkvskkkeekerevrqlhftsWpdkgvpenatsvldllrkvrasqqqagnk......pvivqCsaGvgRsGtfiaidsv

LCSLHgirrDKHSIMIPLLVREMRRQRICMVQSLAQYEFLYKSILIAID
|  ..     .... .   |. .|..|. .||. .|| |.|. .| |.|
lervk....keqvvDvfqvvkvlRkkrpgavqteeqYvfiyeavleald
subfamily_Ptp69D_pd Subfamily Ptp69D 127-366 1.5e-54 180.2 In-house 54-284 (307) alignment 
Range on Protein: 127-366
Range on HMM: 54-284/307.0
YEDILPFDHNRVKLKC-----KNDYINASYIKNLlTGAPDFIASQGPTVPTIRSFWEMIAQYKLSVIVMVTNVLEGDLVKCDPYWP-EigQTLSFGsnse
|||| .||..|||||      . ||||||.||       .|||.|.|   ||  || |||. .. .|||..|. | .  ||. ||| |  ..  .|    
yedikafDktRvkLkkingkedsdYinasfikgy.kekkkfiaaqdPveatigDfWRmiaeqevtlivmlsnlteknrkkcakYWpie..devqyg....

fdgSLSVQQLDASDGVAWSRRTFALHYND------EPERRITQFHYTDWPDQGVPASPHSFVQFVRTVMTSQQRAqasvaaaTPPLLVHCSAGVGRTGTF
   .. |.  . .    . .|.. .  ..      | .|...|.||| |.|  || .... ..... |   ..           |..|||||||||.|.|
...dilvklvseekhsdyiiReldvskkkeesgevedsrkvvqyhytgWkDskvPevargllklieqvrelykln.......rsPivvhCsaGvgrsgif

IgtyaTLCSLHGIRRDKHSIMIPLLVREMRRQRICMVQSLAQYEFLYKSILI
.    .|.||    .  ... |   |...|.||  .||||.||.|||...| 
v....aldsllqqlkaedkvdifetvkdLrsqRnllvqsleqYvflyralld
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 126-399 5.6e-53 175.1 In-house 51-304 (318) alignment 
Range on Protein: 126-399
Range on HMM: 51-304/318.0
SYEDILPFDHNRVKLKC-----KNDYINASYIKNLLTgAPDFIASQGPTVPTIRSFWEMIAQYKLSVIVMVTNVLEGDLVKCDPYWPEIGqTLSFgsnse
 | .||..|| ||||.      . |||||.||         .||.|.|   ||. || |. . . .||||.|.. |   .|.. |||. | . |.     
ryanilaydhtrvkLqmlegeegsDyinanyidGyrr.kkayiaaqaPlpetieDfWrmvWeqnsavivmltqeeergkakvhryWPskg.srsy.....

fdGSLSVQQLDASDGVAWSRRTFALHYNDEPE-RRITQFHYTDWPDQGVPASPHSFVQFVRTVMTSQQRAQASvaaatpPLLVHCSAGVGRTGTFIGTYA
  |.| |.  .  .   .  |.| .. ..| | | . |.|||.|||.|||.|. |....||.| . ||...|.      |..|||||||||||.||   .
..gklvvelkeevelsdyvlrefkvtrteeeesrqvrqyhytsWpdegvpesgaslldlvrqvskaqqksgag......pivvhCsaGvGrtGvfiavdi

TLCSLHgirrDKHSIMIPLLVREMRRQRICMVQSLAQYEFLYKSILiaidEYMRSARGMQNassASLLSQPSKRLKRREL
 |  ..    .   . .   |...|.||  |||   ||||.|. .|    |.. |     .   || |..  ..|.... 
llerik....aealvDvfqtvkqlreqrnlmvqtedqyefiydvll....ealasgdtevd...asdlrsrirelreqdp
subfamily_PTPN13_pd Subfamily PTPN13 124-368 1e-52 174.1 In-house 40-269 (273) alignment 
Range on Protein: 124-368
Range on HMM: 40-269/273.0
ACSYEDILPFDHNRVKLKCKNDYINASYIKNLLtG--APDFIASQGPTVPTIRSFWEMIAQYKLSVIVMVTNVLEGDLVKCDPYWPEIGQtlsfgSNSEF
.  | ..||.|. ||||. .  |||||.||  . |    ..||.|||   |.. || |. . | .||.|||.  |.. |||. ||||. .     ..   
knryrnvlPydetrvklgdeggyinaslikvpv.gkdeyeyiacqGPlPetvkdfwqmvweqkaeviamvtlekekgkvkchrywPeskn.....kklkv

DGSLSVQQLDASDGVAWSRRTFALHYNDEP-ERRITQFHYTDWPDQGVPASPHSFVQFVRTVMTSQQrAQAsvaaatpPLLVHCSAGVGRTGTFIGTYAT
 . | |..|.  .  ... |..|.. ..    |.........||| |||.|. ...|||. | . |.  ..       |..||||||.||.||.|  .. 
snrlevellkvqkldgfvvralavkdsesgesrevahlnfvkwPdhgvPssaaellqfvaevrrlqt.dag.......PivvhcsaGiGrsGtlitidvv

lcsLHGIRRDKhSIMIPLLVREMRRQRICMVQSLAQYEFLYKSILIAI
   |  | ||| .. .  .||..|.||  .||.  || | ||.|| ..
...lglierdk.efdvkeivrklreqrqgvvqtkdqyifvykailevl
subfamily_PTPN14_pd Subfamily PTPN14 126-367 2e-52 173.1 In-house 54-295 (300) alignment 
Range on Protein: 126-367
Range on HMM: 54-295/300.0
SYEDILPFDHNRVKLKC----KNDYINASYIKNLLTGA-PDFIASQGPTVPTIRSFWEMIAQYKLSVIVMVTNVLEGDLVKCDPYWPEIGQTLsfgSNSE
 ..|.||...|||.|.     ...||||| ||  ..|.  ..|..|||   |.. ||.|. . ....|||.|.  |.   |.  |.|. ..     .. |
rfkdvlPyednrvelsptkenstgyinassikvsvggkersyivaqgPleltvqdfWqmvWeqgvqlivmlteeeedgkeksfkyfPkleskk...ktve

FdGSLSVQQLDASDGVAWSRRTFALHY-NDEPERRITQFHYTDWPDQGVPASPHSFVQFVRTVMTSQQRAQASV--AAATPPLLVHCSAGVGRTGTFIGT
| |   |..   .|  .   ... |..   . || .  . ||||||.|||  ...|..... |   ..... .|    . ||.||||||||||||  | .
f.gkfkvttkfsedsdsvittglklkhlpskeertvwhlqytDWpdhgvPeDvkgflsyLeevqsvrrktnseveskeskPPvlvhCsaGvGrtGvlils

YATLCSLHgirrDKHSIMIPLLVREMRRQRICMVQSLAQYEFLYKSILIA
   . .|.      ..| |.  .. .|.||  .||.||||.|.|| ..  
dlliatle....hneeidikkvlarLreqrmllvqtlaqYkfvYkvliky
subfamily_PTPRA_pd Subfamily PTPRA 127-365 2.5e-52 172.8 In-house 64-292 (330) alignment 
Range on Protein: 127-365
Range on HMM: 64-292/330.0
YEDILPFDHNRVKLKCK-----NDYINASYIKNLlTGAPDFIASQGPTVPTIRSFWEMIAQYKLSVIVMVTNVLEGDLVKCDPYWPEIGQtLSFGsnsef
. .|||.|..|| |  |      ||||||.|.        |||.|||   |.  || || ..| . |||.|.. | .  ||  |||. |  ...|     
vvnilPydfsrvilsvkeGveesdyinasfidGy.kekdkfiaaqGPkeetvedfwrmiweqksativmltelkerkeekcaqywPdeGl.vtyG.....

dgSLSVQQLDASDGVAWSRRTFALH-----YNDEPERRITQFHYTDWPDQGVPASPHSFVQFVRTVMTSQQRAqasvaAAtpPLLVHCSAGVGRTGTFIG
   . |.  |    |... | | ..      .....| ..|||.| ||| |||. |   ..... | . .|.      |   |. |||||||||||||| 
..nirvevedetvlvdytvrkflvqqlpdatrekksrlvrqfhftswPdvGvPfepiGmlkllkkvkklnqqs.....ag..pivvhcsaGvGrtGtfiv

TYATLCSLHGirrdKHSIMIPLLVREMRRQRICMVQSLAQYEFLYKSIL
  | |  ..     .. . .   |...| ||  |||.. ||||.|| .|
ldavlervka....erkvdvfefvkrlrlqrpqmvqtdeqyefiykvll
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 127-365 6.7e-52 171.5 In-house 52-280 (305) alignment 
Range on Protein: 127-365
Range on HMM: 52-280/305.0
YEDILPFDHNRVKLKCK-----NDYINASYIKNLlTGAPDFIASQGPTVPTIRSFWEMIAQYKLSVIVMVTNVLEGDLVKCDPYWPEigqtlSFGSNSEF
...| ..|..|..|. |     .|||||||..    .   .|..|||   |.. ||..| ..| |.|||.|.. ||.  ||  ||||     | . . ||
lkeitlldddriiltekeslddsdyinasyvdgy.krkkkyivaqgPlkntvadfWrliveekvstivmltklveggkdkCrqYWpe.....sktekkef

dGSLSVQQLDASDGVAWSRRTFALHY--NDEPERRITQFHYTDWPDQGVPASPHSFVQFVRTVMTSQQRAQASvaaatpPLLVHCSAGVGRTGTFIGTYA
 |..||.  . .    .  | . .    .|. .| ..|.. |||||.||| .. |...... |. .|.. .        ||||||||||||||.||    
.gefsvelksektasdyieRklkisiededkesrtvlqyqltdWPdhGvpqfatsllslikrvqkdqkkdkgv......pllVhCsagvgRtGvfiavdi

TLCSLhgiRrDKHSIMIPLLVREMRRQRICMVQSLAQYEFLYKSIL
 |  |   .    .. .  .....|..|. |||.|.|| ||.  . 
alerl...k.kEevvdvfevlkqlRskrmkmvqtldqYvflhdald
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 126-365 7.6e-52 171.1 In-house 33-265 (274) alignment 
Range on Protein: 126-365
Range on HMM: 33-265/274.0
SYEDILPFDHNRVKLKCK------NDYINASYIKNLLTGAPDFIASQGPTVPTIRSFWEMIAQYKLSVIVMVTNVLEGDLVKCDPYWPEIGQTLSFGSNS
 |..||| .. || |. .       .|||| |||   .    ..| ||| . |.  ||.|| | . .||||.|.. | .  ||  |.|.  ..   .   
ryktilPnensrvllesessededssyinanyikGydeeskayvatqGPlpntvadfWrmiyqeevqvivmltklkeaneqkCavyfPdaedyeiseryg

EFDgslsVQQLDASDGVAWSRRTFALHYNDEpERRITQFHYTDWPDQGVPASPHSFVQFVRTVMTSQQRAQASVAAAtpplLVHCSAGVGRTGTFIGTYA
...    ..  .. .   .| |.. |.|  . ||... . ||||||. .| ........|. | .|.....| .|..    .||||||.|||| ||..  
dve....ikvekiverndysvrklvlkyler.ersvkhywytdWPdhksPddantlldlvleveesreeenaklapv....vvhCsaGiGrtGcfiaisi

TLCSLhgiRRdKHSIMIPLLVREMRRQRICMVQSLAQYEFLYKSIL
..  |   |. .. . .  .| ..| .|  |||.  |||.... . 
avrql...re.eivvdvlkivcnlrldrGGmvqtseqyelihralc
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 126-365 1.3e-51 170.3 In-house 49-274 (315) alignment 
Range on Protein: 126-365
Range on HMM: 49-274/315.0
SYEDILPFDHNRVKL-----KCKNDYINASYIKNLLTgAPDFIASQGPTVPTIRSFWEMIAQYKLSVIVMVTNVLEGDLVKCDPYWPE-IGQTLSFGSns
 |..|||.|..||||     . ..||||||||| . .    .||||||   ..  ||.|. |.| . |||||.  ||| .||  |||.  ...  |||  
ryknilPldsarvkleviddsPdsdyinasyiksvdd.dkayiasqgPlkasvddfwrmvlqekvttivmvtkkqegdkikcrqywPdrkadsvefGs..

efdgsLSVQQLDASDGVAWSRRTFaLHYNDEPERRITQFHYTDWPDQGVPASPHSFVQFVRTVMTSQQRaqasvaaATPPLLVHCSAGVGRTGTFIGTYA
     ..|. |. .       | .    . |  |..|||..|.|||.||.    |...... | .....        . .||||||||||||| .|    
.....ikvellsleadtdgvarkl.vtrkseesrtvtqfqftewPdkGvdkqtssllklikevkadngk.......kefsllvhcsaGvGrtGvviside

TLCslHgIRRdKHSIMIPLLVREMRRQRICMVQSLAQYEFLYKSIL
 .   . |.| ..|. .  .|...|..|. .||.  .| |.| ..|
vva..q.ikr.trsvdvfnfvknlrakrpylvqteeeyafiydavl
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 126-365 2.6e-51 169.3 In-house 48-273 (515) alignment 
Range on Protein: 126-365
Range on HMM: 48-273/515.0
SYEDILPFDHNRVKL-----KCKNDYINASYIKNLLTgAPDFIASQGPTVPTIRSFWEMIAQYKLSVIVMVTNVLEGDLVKCDPYWPE-IGQTLSFGSns
 |..|||.| .||||     . ..||.|||||. . .    .||||||   ..  || .. |.. . |.|||.  ||| .||  |||.  |... |||  
ryknilPydsvrvklevindnPhsdyfnasyipsfdn.dkayiasqgPnkasvddfWrlvlqenvttiamvtklkegdkikcgkyWPdkpgdsvkfGs..

efdgsLSVQQLDASDGVAWSRRTFALHYNDEpERRITQFHYTDWPDQGVPASPHSFVQFVRTVMTSQQRaqasvaaATPPLLVHCSAGVGRTGTFIGTYA
     ..|. .  .      .|.. .  .|.  | .||||.|.|||.|||    |...... | .....        | ||..|||||||||| .|    
.....ikvelvsleactggikrkltvlkgdd.srtvtqfhfteWPdkGvpkhtssllklikevkadhgq.......ythpliihcsaGvGrtGvvisids

TLCSLhgirRDKHSIMIPLLVREMRRQRICMVQSLAQYEFLYKSIL
 .       .. ... .  .|. .|..|  .||   || |.|  .|
vvaha....kttrmvdvfnfvtnirqkrpylvqtqeqyafiygavl
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 127-369 1.1e-50 167.1 In-house 15-243 (250) alignment 
Range on Protein: 127-369
Range on HMM: 15-243/250.0
YEDILPFDHNRVKLKCKN-----DYINASYIKNLlTGAPDFIASQGPTVPTIRSFWEMIAQYKLSVIVMVTNVLEGDLVkCDPYWPEigqtlsfgSNSEF
| ||...|. || |. ..     ||||||...   ..   |||.||| ..||  || |. ..| ..|||.||. | . . .  |||          ..| 
yadiialdssrvvLekekgdkesdyinasflhgy.derkafiatqgPlqatiedfWrmvleeksgtivmLtnLkesekt.yhqywPv........ekaek

DGSLSVQQLDASDGVAWSRRTFALHYNDEPE-RRITQFHYTDWPDQGVPASPHSFVQFVRTVMTSQQRAQASvaaatpPLLVHCSAGVGRTGTFIGTYAT
 |.. |. |.      .  |.. |  . . . | . |.|.. |||.|||.  .. ..... | .|||.|...      |..|.|||||||.|.||  .| 
yGdvtvsllskeefadytkrklklskakkaderivrqlhfvvWPdkgvPevatavLellkkvqasqqqagna......PvivqCsaGvgrsGafiaidav

LCSLHgirRdKHSIMIPLLVREMRRQRICMVQSLAQYEFLYKSILIAID
|  |.   . .. . .  ... .|..|. .|.||.|| |.|. || |.|
lerlk...k.ekvvdvfkvikvlrkdrphavesleqyvfvyeiilkald
subfamily_PTPN1_pd Subfamily PTPN1 125-368 1.8e-49 163.0 In-house 36-271 (290) alignment 
Range on Protein: 125-368
Range on HMM: 36-271/290.0
CSYEDILPFDHNRVKLK-CKNDYINASYIKnLLTGAPDFIASQGPTVPTIRSFWEMIAQYKLSVIVMVTNVLEGDLVKCDPYWPEIGQtlsfGSNSEFD-
  | |. |.|| |.||.  .||||||| .. |      .| .||| . |.  ||.|. . |   .||. .|.| . .||  |||.  .     .. ... 
nryrdvspydhsrikleradndyinaslve.leeakrsyiltqGPlpntvdhfWqmvWeqkskavvmlnkvvekeqikcaqywPqgee....ekellled

GSLSVQQLDASDGVAWSRRTFALHY-NDEPERRITQFHYTDWPDQGVPASPHSFVQFVRTVmtsqqRAQASVAAATPPLLVHCSAGVGRTGTFIGTYATL
 .|.|. .   .   . .|.. |.  . .  | |..|||| ||| ||| || .|..|.  |     |   |..    | ..|||||.||.|||.   . |
tklkvkliseerksyytvrllelenlktqetreilhfhyttwpdfgvpespaaflkflfkv.....resGslssdvGpavihcsaGiGrsGtfclvdtcl

CSLHGiRRDKHSIMIPLLVREMRRQRICMVQSLAQYEFLYKSILIAI
  ..  . |. |. |   . |.|..|. ..|   | .| | .||  .
vliek.kddlssvdikkvllelrkyrlGliqtadqlrfsylaileGa
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 67-370 2e-49 163.4 In-house 10-285 (319) alignment 
Range on Protein: 67-370
Range on HMM: 10-285/319.0
LEQETMRQAAsakykagydnmDSNRSAKRLWREIDSSVAFSTRWCATlligwPPSLRACSYEDILPFDHNRVKLKC-----KNDYINASYIKNLlTGAPD
|...... |.            .... .. ..... .|..... . .     .   .   |..||..|. ||.|.      . ||||||.|         
Lkerlkalas...........tgetllekefkllkeavndtfdsask.....eenkkknryqnilaydrtrvvlseldgvegsdyinasfidgy.qerek

FIASQGPTVPTIRSFWEMIAQYKLSVIVMVTNVLEGDLVKCDPYWPEigqtlsfgSNSEFDGSLSVQQLDASDGVAWSRRTFALHYNDEP--ERRITQFH
||| |.|   ||  || |. ... |..||.|.. |   ||.  ||||         | |  | | |. ..      .  | . |. . .    |....|.
fiatqaPlentiedfWrmvWeeessivvmltklveklkvklkkywpe........enfeeyGrlivtleeeeeledyiirklklnkkssevetRevkhfq

YTDWPDQGVPASPHSFVQFVRTVMTSQQRAQASvaaatpPLLVHCSAGVGRTGTFIGTYATLcslHGIRRDKhSIMIPLLVREMRRQRICMVQSLAQYEF
||.|||..|| .  | ..... .  |... |.       |. ||||||||||||||   |.|     ....   . .   |...| || .|||  .||.|
yteWpdhdvPekatslldllkrirksrektqsg......PivvhCsaGvGRtGtfivldaml...ervkeeg.vlDvfstvsrlRtqRnimvqrpeqYkf

LYKSILIAIDE
.|. .| |.. 
iyealleavea
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 126-368 2.3e-49 162.8 In-house 25-264 (270) alignment 
Range on Protein: 126-368
Range on HMM: 25-264/270.0
SYEDILPFDHNRVKLKCK-----NDYINASYIKNLLTGAPDFIASQGPTVPTIRSFWEMIAQYKLSVIVMVTNVLEGDLVKCDPYWPEigqtLSFGSNSE
 |.||||  . ||.|.         |||| |..        .||..||.  |..||| || . | . |||.|.. |    ||. |||.     .  . . 
RyadiLPsPatRvrleeleedsataYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkgrkkCerYWpa....epkekvkl

FDGSLSVQQLDASDGVAWSRRTFALHyNDEPERRITQFHYTDWPDQGVPASPHSFV--QFVRTVMTSQQRAQASVAAATpPLLVHCSAGVGRTGTFIGTY
 || ..| .|  .    . ..   |. ..  |||.. |.|..|||.||| .. | .  . . ...   .| . . . |. |||||||||||||||.| . 
edgkikvlalseekeegyiltrlrle.ekgeerrlvHfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkae.PllvHcsaGvgRtGtlialD

ATLCSLHgirrDKHSIMIPLLVREMRRQRICMVQSLAQYEFLYKSILIAI
 ... |.     .... .  ...|.|..|. .||   |||||||.... .
iavrlLe....etkkvdvlaiieelRkdRmalvqhpeqyeflykavveya
subfamily_PTPN9_pd Subfamily PTPN9 123-365 1.1e-48 160.8 In-house 44-287 (297) alignment 
Range on Protein: 123-365
Range on HMM: 44-287/297.0
RACSYEDILPFDHNRVKLKCK-----NDYINASYIKNLlTGAPDFIASQGPTVPTIRSFWEMIAQYKLSVIVMVTNVLEGDLVKCDPYWPEIGqtlsfGS
.   |.|.| .|. ||.|. .      |||||...         ||| |||   |.. || |. . .  ||||.| |.|   .||  |||.       .|
eknrytdvlcydetrvvlakvdedeasdyinanfvdGy.kqkkafiatqGplkktvsdfWrmvWeqevlvivmttrvvergrlkcgqyWplee.....es

NSEFdGSLSVQQLDASDGVAWSRRTFALH-YNDEPERRITQFHYTDWPDQGVPASPHSFVQFVRTVMTSQQRAQASVA------AATPPLLVHCSAGVGR
 .|| |.|||....     ..  |.. ..  ..| .|..| | .. ||| ||| | .|.......|   |  |  ...      .  ||..||||||.||
saef.gdlsvsnveveeeedykvrvleiknvkteesrkvthfqflsWPdyGvPssaaslldvlekvrekqalavkelgdewkghpsgPPivvhcsaGiGr

TGTFIGTYATLCSLhgirRDKHSIMIPLLVREMRRQRICMVQSLAQYEFLYKSIL
|||||    .|  |    ...  . .   |. .| ||  ..|   |||| |...|
tGtfitldiclsrl....eevgtvdvvetvkllrtqrafsiqtpeqyefcylavl
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 126-365 3.9e-48 159.0 In-house 54-276 (315) alignment 
Range on Protein: 126-365
Range on HMM: 54-276/315.0
SYEDILPFDHNRVKL-----KCKNDYINASYIKNLlTGAPDFIASQGPTVPTIRSFWEMIAQYKLSVIVMVTNVLEGDLVKCDPYWPEIgqtlsfgsnSE
 | .|...|. ||.|     . . ||.||..|.   .    .||.||| | ... || .. ..... |||.||. ||.  |.. |||.            
ryiniiaydksrvqlpllendphsdyvnanfidGy.nkkrryiaaqgpnvasvkdfwrlvfeedigkivmltnlvegekrkaekywpdk.........kv

FDGSLSVQQLDASDGVAWSRRTFALHYNDEpERRITQFHYTDWPDQGVPASPHSFVQFVRTVMtsqQRAQASVaaatPPLLVHCSAGVGRTGTFIGTYAT
  | ..| . .      .. ||..  ..|.  | . |.||| ||| |||..  ......|||.   |  ..||     ...||||||||||||||   | 
iyGkitvtrkseevnteytvrtlsvvfgdn.irevvqlhytswpdmgvpkytiplmnlirtvk...qhhtnsv....gaivvhcsaGvGrtGtfitldav

LCSLHgirrDKHSIMIPLLVREMRRQRICMVQSLAQYEFLYKSIL
|  ..     .. | .  ... .|..|| |||...||.|.|. .|
ldqae....aenaidvynfitgvrqnrikmvqvaeqyqfiydall
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 126-367 6e-47 155.2 In-house 56-283 (297) alignment 
Range on Protein: 126-367
Range on HMM: 56-283/297.0
SYEDILPFDHNRVKLKCKN-----DYINASYIKNLLTgapDFIASQGPTVPTIRSFWEMIAQYKLSVIVMVTNVLEGDLvKCDPYWPEIGQTLsfgsnse
 |..|||.| .||||.  |     ||.|||..|        .|..| |   |.  || |. ... |.|||...  |.|  ||  ||.. | |        
RYkniLPydssRvkLaivnddpdsDyvnasfvkgnkh...rlittqmPmkatvadfWamvldeqvstivmlnddnerdk.kcaryWsdkgvtt.......

FdGSLSVQQLDASDGVAWSRRTFALHYND-EPERRITQFHYTDWPDQGVPA--SPHSFVQFVRTVmtsqQRAQASVAAAtpPLLVHCSAGVGRTGTFIGT
| |..||. |  |.    ..|.. .  ..   .| . |.....|||. |.   | .|.....  |    .    ..| .  ||||||.||||||| ..  
f.GdvsvvllsvsereGfikrelevtkgkakarrvvkqyqfveWPdkaverkdsassllklisev....rkdfsqnaeg..PllvhclaGvGrtgvllti

YATLCSlhgIRRDKhSIMIPLLVREMRRQRICMVQSLAQYEFLYKSILIA
   ..    ..|.| .. |  ||. .|..|  .||   ||.|.|. .| |
dsvvae...akrek.evdifglvkklrqerpylvqtkeqykfvyvavlea
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 125-375 4.7e-46 152.4 In-house 52-291 (325) alignment 
Range on Protein: 125-375
Range on HMM: 52-291/325.0
CSYEDILPFDHNRVKLKCK-----NDYINASYIKNLlTGAPDFIASQGPTVPTIRSFWEMIAQYKlSVIVMVTNVLEGDLVKCDPYWPEI-GQTLSFGSn
  .......|..|| |. |      |||||||...   .   |.|.| |   ||  .| .. ... . .|.|.|.|...  .|  |||.  |..  ||. 
nrfknvvaldksrvvletkkddpssdyinasylrdd.kkkdvflaaqaPltatindlWrlvldWr.csvvvvlneldlgkdrcavywpkemgksktfGg.

sefdgsLSVQQLDASDGVAWSRRTFALHYNDEP-ERRITQFHYTDWPDQGVPASPHSFVQFVRTVMTSQQRAQASVAAATpPLLVHCSAGVGRTGTFIGT
      | |.   . .   .  | . .   ..   | . ||..  |.| ||.  | ... ....| . ..| .|   |.| |.||||||||||||.||  
......levklrtieeisdyvhrvldvkqvkkGetrsvkqfqlqswddmGvqkrpatlisilqlvkavservtantkast.pilvhcsaGvGrtGvfisl

YATLCSLhgIrrDKHSIMIPLLVREMRRQRICMVQSLAQYEFLYKSILiaidEYMRSA
|. |  .  |  .. .. |   |. .|..|  ||..  || ..|...     |.. |.
ysalakv..i..eesrvdifgfvkklrkdrpsmvetvdqyiliyealv....eaymsg
subfamily_PTPRK_pd Subfamily PTPRK 127-367 1e-45 151.0 In-house 49-276 (314) alignment 
Range on Protein: 127-367
Range on HMM: 49-276/314.0
YEDILPFDHNRVKLKC-----KNDYINASYIKNLlTGAPDFIASQGPTVPTIRSFWEMIAQYKLSVIVMVTNVLEGDLVKCDPYWPEIGQTlsFgsnsef
..|||..|. ||.|.      ..|||||..|    . .  ||. |||   |.. || .. ... . |||.|.. |   |||  |||| ...  .      
sgdilaydrsrvflitidgdpssdyinaalidsy.krpaafivtqgPlqetvkdfWrlvydencasivmltelvevgrvkClkyWPedtev..y......

dGSLSVQQLDASDGVAWSRRTFALHY---NDEPERRITQFHYTDWPDQGVPASPHSFVQFVRTVMTSQQRaqasvaaATPPLLVHCSAGVGRTGTFIgty
 | . |. ....       |.|...    . |  | . ||... ||| .|| | ......|| | .||.           ...|||||| |||||||   
.gdikvelvetellaelvvrifrveklargqeeirevrqfqflgWpdhdvPvsatgllklvrrvkksqee.......eaGrivvhCsaGaGrtGtfi...

aTLCSLHGIRRDKHSIMIPLLVREMRRQRICMVQSLAQYEFLYKSILIA
 .....  . . .. . .   |...| ... ||.   || |.|  || |
.aidivldmieregvvdvfnavktlrsrkvnmveteeqykfiydvilea
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 126-365 1.2e-45 151.2 In-house 66-288 (319) alignment 
Range on Protein: 126-365
Range on HMM: 66-288/319.0
SYEDILPFDHNRVKLKCK-----NDYINASYIKNLLtGAPDFIASQGPTVPTIRSFWEMIAQYKLSVIVMVTnvlegdLVKCDPYWPEIGQTlsfgsnSE
 . .||.||.|.|||.        ||||||...        .||.|||   |.  || || .|. | ||..|        ||  |||  ..        |
riinilafdknvvklerliGeefsdyinasfvtGyq.rkdkyiaaqGPldntladfWrmiweyncstivllt......kdkcsqywplkivi......ke

FDGSLSVQQLDASDGvaWSRRTFALHY--NDEPERRITQFHYTDWPDQGVPASPHSFVQFVRTVMTSQQRAQASVaaatpPLLVHCSAGVGRTGTFIGTY
  . ..|. .. ..   .  | . |    . .  |.|||||.  |||.||| .|  ....|. |   ... .        ...|||||||||||..|   
erfkvkvdsveetae..yvvrdielsedgkekdirkitqfhflGwpdvGvpdypsdlmrlvkkvrhltskenhra.....nivvhcsaGvGrtGvyivld

ATLCSLhgirRDKHSIMIPLLVREMRRQRICMVQSLAQYEFLYKSIL
. |  .    .... . .  .||..|.||  .||.|.|| |.| ..|
vlldrm....keekqvdvynfvrdlrqqrntlvqdlvqykfiysall
subfamily_PTPRG_pd Subfamily PTPRG 127-369 2e-45 150.1 In-house 53-288 (563) alignment 
Range on Protein: 127-369
Range on HMM: 53-288/563.0
YEDILPFDHNRVKLKC-----KN-DYINASYIKNLLTgAPDFIASQGPTVPTIRSFWEMIAQYKLSVIVMVTNVLEGDLVKCDPYWPEiGQTLSFgsnse
| .|...|. ||||.      |. |||||.||.     . .|||.|||   |.  || || . . ..|||.||. |    ||| |||.  ... .     
ylnivaydrsRvklsplpgkkkklDYinAnyidGyqk.skafiatqgplkdtfddFWrmiWeqnvaiivmitnlvergrrkcdvYWPk.desety.....

fdGSLSVQQLDASDGVAWSRRTFALHY------ND-EPERRITQFHYTDWPDQGVPASPHSFVQFVRTVmtsqqraQASVAAATPPLLVHCSAGVGRTGT
  |.|.|.. .    .  . ||. ..       .. . |....|.|||.|||.||| ..   ..||.         .|.  |.. |..||||||||||||
..galqvtlieeevlalytvrtlviknlklkkkkqcdteklvrqyhytkWPdhgvPehslpvLifvkks.......saankaeaGPivvHcsaGvgrtGt

FIgtyaTLCSLHGIRRDKHSIMIPLLVREMRRQRICMVQSLAQYEFLYKSILIAID
.|     | .|.   ...... .  ... .| ||  .||.  || ||.. .| || 
yi....vldtllkqiqqenavnvfgflkhiraqRnflvqteEqYiflhdalleaia
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 127-365 5.7e-45 149.0 In-house 31-252 (284) alignment 
Range on Protein: 127-365
Range on HMM: 31-252/284.0
YEDILPFDHNRVKLKCK-----NDYINASYIKNLLtGAPDFIASQGPTVPTIRSFWEMIAQYKLSVIVMVTnvlegdLVKCDPYWPEIGQTlsfgsnSEF
. .||.||.|.|||.        ||||||.|.        .||.|||   |.  || || .|. | ||..|        ||  |||  ..        | 
ighilafdknvvklerliGeefsdyinasfitGyq.rkdkyiatqGPldntladfWrmiweyncstivllt......kdkcsqywplkivi......kee

DGSLSVQQLDASDGvaWSRRTFALHY--NDEPERRITQFHYTDWPDQGVPASPHSFVQFVRTVMTSQQRAQASVaaatpPLLVHCSAGVGRTGTFIGTYA
 . ..|. .. |.   .  | . |    . .  |.|.|||.  |||.||| .|  ....|. |   ... .        ...|||||||||||..|   .
rfkvkvdsveesee..yvvrdielsedgkekdirkirqfhflgwpdvgvpdypsdlmrlvkkvrhltskenhra.....nivvhcsagvgrtgvyivldv

TLCSLhgirRDKHSIMIPLLVREMRRQRICMVQSLAQYEFLYKSIL
 |  .    .... . .  .||..|.||  .||.|.|| |.| ..|
lldrm....keekqvdvynfvrdlrqqrntlvqdlvqykfiysall
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 128-372 1.8e-43 143.6 In-house 54-282 (287) alignment 
Range on Protein: 128-372
Range on HMM: 54-282/287.0
EDILPFDHNRVKLK-CKNDYINASYIKNLlTGAPDFIASQGPTVPTIRSFWEMIAQYKLSVIVMVTNVLEGDLVKCDPYWPEIGQtLSFGsnsEFDGSLS
..||. | .|| || ...|||||..|.     .  ||....| . |.| ||..| . . ..|||...  | |  .|  ||||    ...|   |.  .| 
tqilvpdnyrvllkgehpdyinavfidgy.kekkafiiaesPmfntarnfWkliddrnvtaivmlcqekendeevcyqyWpeeks.vvlG...eyniell

VQQldASDGVAwsRRTFALH--YNDEPERRITQFHYTDWPDQG-VPASPHSFVQFVRTVMTSQQRAQASvaaatppLLVHCSAGVGRTGTFIGTYATLCS
 ..   ..|.    |.. ..   .........|...|.|...| |.    ..... . . | ..|...|       ..||||..|||...|.    |.  
nee..vnagyi..erklevknknkagdkqqvkqyqitnWdstgkvtepqtillvieemyktqrkrgnts.......ivvhCsdtvGrsamfcaaattink

LhgirRDKHSIMIPLLVREMRRQRICMVQSLAQYEFLYKSILIAIDEYM
     .    | .  .....| |.  .||  .||.|... .|. .| ..
c....kteGviDvfqvlksqriqkpgsvqtveqykfindivleyldsfe
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 125-365 1.4e-42 140.5 In-house 42-274 (287) alignment 
Range on Protein: 125-365
Range on HMM: 42-274/287.0
CSYEDILPFDHNRVKLKCK----NDYINASYIKNLlTGAPDFIASQGPTVPTIRSFWEMIAQYKLSVIVMVTNVLEGDLVKCDPYWPEIGQTLSFGSNSE
  | |.||.|..|| |  .     ||||| |.    |    |||.|||   |.|.|| .. . . ......|  .|    ||  ||||  . .  |  | 
nryadvlPiddtrvllsaegelGsdyinanyvasy.tddeafiaaqgPiaatvrdfwravletrsasvitmtreveearlkcykywPerevPmrvGGysv

FdgSLSVQQLDAsDgvaWSRRTFALHYNDEPE-RRITQFHYTDWPDQGVPASPHSFVQFVRTVMtsQQRAQASVAAATPPLLVHCSAGVGRTGTFIGTYA
    |. ....  .   .. |.. |   .  | | . |... .|||.... .  ....||  |   |.   |  |. . ||.||...|.||.|... |..
v..lldydikeP.e...ygvralrlidletrearvvkqldllswPdkvlaPtavglirfvldvk..qhielardasevGPlvvhddvGiGrsGillatlv

TLCSLHGIRRdkhsIMIPLLVREMRRQRICMVQSLAQYEFLYKSIL
 .  |  . |    . .   |  .| .| ..||.  |. .||... 
lvsrledlGr....vdvaavvirlreyraalvqavvqlrllyealv
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 127-372 1.5e-42 140.5 In-house 52-287 (290) alignment 
Range on Protein: 127-372
Range on HMM: 52-287/290.0
YEDILPFDHNRVKLK-------CKNDYINASYIKNLlTGAPDFIASQGPTVPTIRSFWEMIAQYKLSVIVMVTNVLEGDLVKCDPYWPEIGQTLsFGsns
...|.. | ||. |.       |.|.||||.|||.    . ..|| |||.  |.. ||..| | | ..|||.||. | . |||  |||. ...  .|   
fanivvyddnritLrpisghkDCtneyinAcyikgy.kekkqyiatqgpvsntlvdFWkliwqekvtiivmltniieegkvkCqqYWpdsdtka.yg...

efdgSLSVQQLDASDGVAWSRRTFALHYNDE--PERRITQFHYTDWPDQG-VPASPHSFVQFVRTVMTSQQRAqasvaaaTPPLLVHCSAGVGRTGTFIG
      |.. |. .      .|.. .. ...  ... .||.. | |...| |..   . ... . . |  .|          ...||||..|||...|. 
....efsikllneetlneyierklevknknsagakqsvtqyqitnwdstgkvtnpqtillvieemyktqrkrg.......ntsivvHCSdtvgrsavfca

TYATLCSLhgirRDKHSIMIPLLVREMRRQRICMVQSLAQYEFLYKSILIAIDEYM
.. |.       . .  | .  .....| |.  .||.  ||..... .| ..|...
aattinkc....ktegvidvfqvlksqRiqkpgsvqtvqqyqgifqivltyldsfe
subfamily_PTPRN_pd Subfamily PTPRN 121-365 9.2e-41 134.5 In-house 56-289 (297) alignment 
Range on Protein: 121-365
Range on HMM: 56-289/297.0
SLRACSYEDILPFDHNRVKLKCK-----NDYINASYIKNLLTGAPDFIASQGPTVPTIRSFWEMIAQYKLSVIVMVTNVLEGDLVKCDPYWPEIGQTLSf
 ..   ....||.||.||||| .     .|||||| | .    || .||.|||   |. .||.|. .    |||..|.. | .. .|. |||. |. .  
nvkknrskavlpydhsrvklkeeasaeksdyinasaildhdprapayiatqgplastvadfwqmvweqGvvvivnltrleeegvkqckrywpdeGsevy.

gsnSEFDGSLSVQQLDASDGVAwsrRTFALHY-NDEPERRITQFHYTDWPDQGVPASPHSFVQFVRTVMTSQqRAQASvaaatpPLLVHCSAGVGRTGTF
     ..  |  . . . | .    |.| |   . .  | .||||.  ||..|||||..|...| | |  |  | ...      |..||||.|.||||..
...hiyevhlvsehiwcddylv...rsfylknlqtsetrtvtqfhflswpeegvPasaksllefrrkvnksy.rGrsc......pivvhcsdGaGrtGvy

IGTYATLcslHGIRRDKHSIMIPLLVREMRRQRICMVQSLAQYEFLYKSIL
|     |   . . .  . | |   .  .| ||  .|.. .|.|| .... 
ilidlvl...nrllkGvkeidiaatlehlrdqrpglvktkdqfefaltava
0051429 (Phosphotyrosine protein) phosphatases II 144-377 2.8e-40 134.0 In-house 4-234 (272) alignment 
Range on Protein: 144-377
Range on HMM: 4-234/272.0
NDYINASYIKNLltGA---PD-FIASQGPTVPTIRSFWEMiAQYKLSVIVMVTNVLEGDLVKCDPYWPEIGQT----LSFGSNSEFDGSLSVQQLDASDG
..||||.... .  |    |. ...|.||.  |...|| . .......||..... | . .|||.||| |       |...  . . | |.|  |  .  
sgyiNardvggy..grvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseell

VAWSRRTFALH---YNDEPeRRITQFHYTDWPDQGVPASPhsFVQFVRTVMTsqqraqasvaaaTPPLLVHCSAGVGRTGTFIGTYATLcslHGIRRDK-
  .  |.. |.   ...|. |.....||||||| ||| ..  ...... . .              |.|||||||..||||..  .  |   .|. ..  
ldyilrellltlllsagea.revmhlhytdwpdhgvpqea..llellellld............ggpvlvHCsaGkdRTGtvvalllll...lgvsleti

------HSIMIPLLVREMRRQRICMVQSLAQYEFLYKSILIAIDEYMRSARG
       ....   |.|.|.|| ..||. .||.|||. .| ...... . . 
vddYlltnlyleeaveelraqrpgavqteeqylflyeallellrsllsvrae
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 126-365 4.5e-40 132.4 In-house 8-236 (237) alignment 
Range on Protein: 126-365
Range on HMM: 8-236/237.0
SYEDILPFDHNRVKLKC---KNDYINASYIKNLLTGAPDFIASQGPTVPTIRSFWEMIAQYKLSVIVMVTNVLEGDLVKCDPYWPEIGQTLSFGSnseFD
 | .|  .||.|| ||    . |||||.|.|..      .||.|||  ..   ||.|. | | |||||.| ..||. .||  |||.  |  ..|    . 
rygnivaydhsrvvlkgagsgsdyinatylkgfdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywpstdqpaaygv...lt

GSLSVQQlDASDgvaWSRRTFALHY--NDEPERRITQFHYTDWPDQGVPASPHSFVQFVRTVMTSQQRaqasVaAATPPLLVHCSAGVGRTGTFIGTYAT
 ||  .. . ||   .. |.. | .  . .  | | |...| |||.|||    ....| . ..   .     | . . | ..|||||||||| |.   | 
vslkkke.efsd...ytvrslllskrltlkevrlihqyqftswpdrgvpqqtaallrfrkniinrsph....v.sesgpwiihcsagvgrtgiflvidam

LCSlhgiRRDKHSIMIPLLVREMRRQRICMVQSLAQYEFLYKSIL
|       ..|. . |   |  .  .|  ..|.  || |....||
lrq....akekkvvdiynyvysieedrpyiiqtkdqyvfihqtil
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 125-365 4.8e-40 132.2 In-house 37-263 (283) alignment 
Range on Protein: 125-365
Range on HMM: 37-263/283.0
CSYEDILPFDHNRVKLKCK-NDYINASYIK--NLLTGAPDFIASQGPTVPTIRSFWEMIAQYKLSVIVMVTNVLEGDLVKCDPYWPEIGqTLSFGsnsEF
  ...|.| | .||.|| . .|||||..|   .      ..|..|.|   |.. || |. . | . |||.|.. |.  .||  |||. | .  .|   ||
nrnqeivpadqwrvelksesrdyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfdekitaivmltklqedlrikCsqyWPkrG.sedyG...ef

dgSLSVQQLDASDgvAWSRRTFALHYN--DEPERRITQFHYTDWPDQGVPASPHSFVQFVRtVMTSQQRAQASvaaatpPLLVHCSAGVGRTGTFIGTYa
   .....  .|.  ..... . |..|   . .  .. . . || . |  |   |.|.| . |.. |.. . .      |..||||.|.|||..||.   
..tvtlrkettsn..sfiikelllrvnssakstlllahyqvidWleygeqaiinslvkfnk.vislqteskkg......PivvhCstgiGrtavfiaas.

tlCSLHGIRRdKHSIMIPLLVREMRRQRICMVQSLAQYEFLYKSIL
  .|.. ..  .  . ..  |. || ||. .||.| || .... .|
..asvkdalt.esvvdvfavvkimreqrmmavqtldqyklvhelvl
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 124-365 3.3e-39 129.4 In-house 48-233 (392) alignment 
Range on Protein: 124-365
Range on HMM: 48-233/392.0
ACSYEDILPFDHNRVKL-----KCKNDYINASYIKNLLTgAPDFIASQGPTVPTIRSFWEMIAQYKLSVIVMVTNVLEGDlvkcdpywpeigqtlsfgsn
   |..|||.| .||||       ..||.|||||... .    .|||||| . ..  ||.|. | . . |.|||.. |||                    
knryknilpydsarvkleviddipdsdylnasyipsfdn.ekayiasqgpnaaslddfwrmvfqenvttiamvtklkegd....................

sefdgslsvqqldasdgvawsrrtfalhyNDEPERRITQFHYTDWPDQGVPASPHSFVQFVRTVmtsqqraQASVAAATPPLLVHCSAGVGRTGTFIGTY
                             . .  | ..|||.|.|||..||    |...|.. |       .|     | ||..||||||||||  |   
.............................kgddartvaqfhftewPdkdvpkhtssllkfikev.......kadfGqythpliihcsagvgrtgvvisid

ATLCslHgiRRDKHSIMIPLLVREMRRQRICMVQSLAQYEFLYKSIL
. ..  |   .  . . .  .| ..||.|  |||.  || |.| ..|
svva..h..akktrmvdvfnfvtnirrkrpymvqtkeqyafiygavl
0041856 (Phosphotyrosine protein) phosphatases II 126-365 3.8e-39 129.5 In-house 6-168 (182) alignment 
Range on Protein: 126-365
Range on HMM: 6-168/182.0
SYEDILPFDHNRvklkcKNDYINASYIKNLLTGAPdFIASQGPTVPTIRSFWEMIAQYKLSVIVMVTnvlegdlvkCDPYWPeigqtlsfgsnsefdgsl
 |.||||.||.|      .|||||...   | .   ||| |||.  |. .|..|. ... ..||..|         ...|||                  
rysdilpydhsr.....dldyInanlylgslpatr.fiatqgpllstvadflrmlkelgittivnlt.........eelywp..................

svqqldasdgvawsrrtfalhynDEPERRITQFHYTDWPDQGVPAsPHSFVQFVRTVMTsqqraqasvaaATPPLLVHCSAGVGRTGTFIGTYatLC--S
                       .. || ..|..|. ||| |||  ......|...|                | |||||||||||||... |  |.   
.......................ellerlgiqylylpwpDhgvpd.ldelldfieevle...........eggpvlVHCsaGvgRtgtlvaay..lmkkl

lhgirrdkhSIMIPLLVREMRRQRICMVQSLAQYEFLYKSIL
         .. ..  |...|..| .||... || ||.  .|
.........gvsleeavklvrsrRpgmvitpnqyfflqlall
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 120-367 7.3e-39 128.4 In-house 32-294 (297) alignment 
Range on Protein: 120-367
Range on HMM: 32-294/297.0
PSLRACSYEDILPFDHNRVKLK---CKNDYINASYIKNLLTGAP-DFIASQGPTVPTIRSFWEMIAQYKLSVIVMVTNVLEGDLVKCDPYWPEIGQTLSF
 |||   | ||| .| .||||.    ..||||| |.      |.  .| .|||.  |.  ||...|.  . |||||... |.   || ||||.. |    
sslrknryrdilatddtrvkllrviterdyinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmvaklqedGrdkcapywpsvvqerlk

GsNSEFDGSLSvQQLDASDGVAWsrRTFALHYNdEPERRITQFHYTDWPDQGVPASPHSFVQF----------VR---TVM---TSQQRAQ-ASVAAATP
   .     || .  |  | |      . | |  . .| ..   .  ||| |||.  .  |.|          |    ...   |.    |  |. |. |
a.gdvvvefls.stsdefdrvil..telqliyr.sesrvvrhvqflswpdhGvpsdledlvrfqaqvcscciavpmmlalvemftamvflqleslraemp

---PLLVHCSAGVGRTGTFIGTYATLCSLhgirRDKHSIMIPLLVREMRRQRICMVQSLAQYEFLYKSILIA
   .|||||||||||.|  . . . |  |    | |.   .  ... .| ||  .||.| |.|.||. .|  
rnayllvhcsaGvGrsGvvvlsdvilakl....rkkripdvaailsilreqrarlvqtleqfellydavlkk
0036282 (Phosphotyrosine protein) phosphatases II 144-362 3e-38 126.6 In-house 2-164 (174) alignment 
Range on Protein: 144-362
Range on HMM: 2-164/174.0
NDYINASYIkNLLTGAPDFIASQGPTVptirsFWEMIAQYKLSVIVMVTNVLEGDLVKCDPYWPEigqtlsfgsnsefdgslsvqqldasdgvawsrrtf
.||||||.. .|    | .||.|||.      ||||. .......||...  | .|.||  ||||                                   
sdyinaspl.dlsyitprliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe...................................

alhYNDEPERRITQFHYTDWPDQGVPASPHsFVQFVRTVMTSQQRaqasvaAATPPLLVHCSAGVGRTGTFIGTYATLCSLHgirrdKHSIMIPLLVREM
   . . .|| . |..|. ||| ||| ..  . .||. | . ...          |.|||||||||||||... |  |. |.        . .  ||||.
...lredlerlgiqylylpwpDhgvpdlsi.llefvkfveealse......dpggpvlVHCsaGvgRtGtlvaaylmlrgll.....eslvdaldlvrel

RRQRICMVQSLAQYEFLYK
|.|| .|||.  ||.|||.
RlqrpgmvqtpsQyrflyy
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 125-368 3.1e-37 123.0 In-house 52-279 (439) alignment 
Range on Protein: 125-368
Range on HMM: 52-279/439.0
CSYEDILPFDHNRVKL-----KCKNDYINASYIKNLLTGApDFIASQGPTVPTIRSFWEMIAQYKLSVIVMVTNVLEGDLvkcdpYWPEIGQTLSFGSNS
  |.|. .||| || |       .  |||| |||   .    .||.|||.  |  .|| .. . | . |||.||..|        |||  ...       
nrykdvgafdhtrvtlqeipgvphshyinanyikGyyddk.lyiatqgpkkettddfwrlviekktvtivmltnlvesyk.....ywpsdaevcygdiav

EFDGSLsvqqlDASDGVAWSRRTFALHYNDEPERRITQFHYTDWPDQGVPASPHSFVQFVRTVMTSQQRAQasvaaaTPPLLVHCSAGVGRTGTFIGTYA
  |  .     .  . |    . |  . . | || . ||||. |||. |||     ..|.|.. ..... .      . |..|||||||||||| |    
rvdrni.....elpnyvirgfkvfnerdttekertvlqfhyiawpdknvpaqashvldflrainsandkee......ygpvvvhcsagvGrtGtiialdi

TLCSLHgirRdKHSIMIPLLVREMRRQRICMVQSLAQYEFLYKSILIAI
.|  |.     .  . |  .|. .|.||  |||.|.|| |.|...|  |
aleqlk...l.enkvdikgivkvlrkqrkqmvqalcqyvfiynavledi
RhoGAP RhoGAP domain 1078-1224 6.1e-37 114.0 Pfam-A 1-149 (152) alignment 
Range on Protein: 1078-1224
Range on HMM: 1-149/152.0
PRLVHSIMQLVERRGLMYEGIYRVSGSLPRVDKLKAAALMQGPH--VLEDAEIPELTSLLKLVLKSMNPPLLTFAAHAAFCRAIRLPEGETRNEALSAAL
| .| .... .|.|||  |||||||||  ||..|..|   .      ||. ..  ..||||. |...  ||||. .. .. .| . .. |.| |||...|
PlivekcvefiekrgldtegiyRvsgskarvkelreafekgkavdldleeedvhvvaslLKrfLrelpepLltkelyeelleaaksedeeerlealkell

RVLPTKNYRLLDSLMRHLRRVVAECSSNRMNQENIALVFGPTIARSPRG
. ||  |...|  |..||.|| .  ..|.|. .|.|.|||||. |.. .
ekLPkenratLryLlehLkrvasnskenkMtaknLaivfgPtLlrpkss
RasGAP GTPase-activator protein for Ras-like GTPase 470-637 4.9e-36 111.6 Pfam-A 5-197 (197) alignment 
Range on Protein: 470-637
Range on HMM: 5-197/197.0
LAEFDVHACDSENLLFRRNSLGSKLLTATLKT-YGQGYLRKTLQPVIQKMLdTPDLSYEINPAYIA---------------------KGENLGQNRSALK
| ...|  ... | |||.||| .|||.  .|  .|| ||.|.|.|..||.| . |...|..| .|.                     . ..| .|   |.
liklEversedpntlfrgnslatklleeftkrpegqeyLkkilkpllqkil.kedknlelDprkiyeklrkkkeerksseeasedekedqeleknidklr

KLSEFVFDAIIDSLARVPVAVTLTCHGIHRAATKAFPD----SGNLAVGNCFFLRFLSPALVTPKAHGIItDD-LPPKVSRGLVLLSKVVQAVAS
.| . ...||. || ..|. .  .|. |. .. . |||        |... .||||| ||.|.||  |.. |  . ....| |.|..||.| .|.
elvneileaIfksledlPqgiriickqirekveekfpdadeeeilnaissflflrfliPaivsPklfglv.dhqiseetrrnltliakvlqnlan
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 134-366 6.5e-36 118.5 In-house 53-291 (301) alignment 
Range on Protein: 134-366
Range on HMM: 53-291/301.0
DHNRVK-------LKCKNDYINASYIKNLlTGAPDFIASQGPTVPTIRSFWEMIAQYKLSVIVMVTNVLEGDLVKCDPYWPEIG-QTLSFGSN------S
|.||.         .|...|||||||..  . .  |||.|||   |.. || .| |.| . ||||||  ||   ||  |||.   .. .||        .
ddnriilkpkpnldlcqreyinasyidgy.sekkkfiaaqgpmkktlvdfWrliwqekpvsivmvtnlkegtkskceqywpnseaeseefgpftvtlvne

EFDG-----SLSVQQLDASDGvAWSRRTFALHYNDePERRITQFHYTDWPDQGVPASPHSFVQFVRTVMTSQQRAQASvaaatpPLLVHCSAGVGRTGTF
         .|.|.  |.|.  .   |.|. . .    . ..|.. ||||..||   |.  .| .  |.  ||.   .      |..||||..|.|.|..
qvyPdfvirqlnvkiqdgsnn.gyierkfkvksdk.sswdvlqlqvtdWpqdGvvreprtvLqviddvihrqqkiggg......pvvVHCSdtVsrsGvY

IGTYATlcsLHGIRRDkHSIMIPLLVREMRRQRICMVQSLAQYEFLYKSILI
.    .   |   ...   . .  ... .||..  .|. | || ..|. |  
csvsig...lEQckae.gVVdvfqvtkavrrskpgaVtTLeqytsiydvidm
0043147 (Phosphotyrosine protein) phosphatases II 144-361 2.8e-35 116.9 In-house 5-154 (172) alignment 
Range on Protein: 144-361
Range on HMM: 5-154/172.0
NDYINASYIkNLLTGAPDFIASQGPTVPTIRSFWEMIAQYKLSVIVMVTNVlegdlvkcdpywpeigqtlsfgsnsefdgslsvqqldasdgvawsrrtf
.|||||||. .|    ..||| |||.  |. .||.|. ... ..||..|.                                                  
sdyinasyl.dlyyipdrfiatqgplrntladfwrmlkelgithivnltel.................................................

aLHYNDEPERRITQFHYTDWPDQGVPaSPHSFVQFVRTVMTSQQRAQasvaaaTPPLLVHCSAGVGRTGTFIGTYATLcslhgirrdkHSIMIPLLVREM
 |.. .  || . |..|. |||.||| ..  . .|.. . . ... .        | |||||||||||||..  |  |          ... .   |...
.lydpellerlgiqylylpwpDhgvp.llellleflefidellalsp......ggpvlVHCsaGvgRtgtlvaaylml..........lglsleeavalv

RRQRICMVQSLAQYEFLY
|..| ..||.  || |||
rekRpgavqnpsqyrfly
0046846 (Phosphotyrosine protein) phosphatases II 145-363 1.4e-33 111.5 In-house 13-168 (176) alignment 
Range on Protein: 145-363
Range on HMM: 13-168/176.0
DYINASYIKNlltgaPDFIASQGPTVPTIRSFWEMIAQYKLSVIVMVTNVLEGDLVKCDPYWPEiGQTL-Sfgsnsefdgslsvqqldasdgvawsrrtf
|||||..|       . .|| |||.. |. .|.||. ... ...|..|.  | . .||. ||||  ..|                               
dyinanlilg.....srpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpe.leklgi.............................

alhyndeperritQFHYTDWPDQGVPASpHSFVQFVRTVMTSQQRAqasvaaatPPLLVHCSAGVGRTGTFIGTYATLCslhgirrdKHSIMIPLLVREM
             |.....||| ||| .   . .... . . ...          | |||||||.|||||..  |   .        .. . .   ....
.............qylhlpwpDhgvpdl.elllellefirealkeg........gpvlVHCsaGigRtgtlvaayllel........ekglsveealalv

RRQRI-CMVQSLAQYEFLYKS
|.||  ..||. .||.|||. 
reqRplgavqtpeQyrflyef
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 126-365 2e-33 110.7 In-house 46-274 (307) alignment 
Range on Protein: 126-365
Range on HMM: 46-274/307.0
SYEDILPFDHNRVKLKCK---NDYINASYIKNlLTGAPDFIASQGPTVPTIRSFWEMIAQYKLSVIVMVTNVLEGDLVKCDPYWP-EIGQTLSFGSNSEF
 |.|.   |..|. .| .    ||| | |.    .    ||..|||   |. ||| |. | |.  ..|. .|.|   .||. ||| | ||.| ||.... 
ryqdvkcqdkgrivvkfdglasdyihanylgi.aikpkkficaqgplentqysfwamaiqekvesvimlckvielakikceqywpleegqklvfgeapnt

D--GSLSVQQLDAsDGVAWSRRTFALHYNDEpERRITQFHYTDWPDQGVPASPHSFVQFVRTvmtsqqraqasVAAATPPLLVHCSAGVGRTGTFIGTY-
     | ...|   |       |. . . ..  | |... ...|||.|||    . . .. .           |   | |..|||||||||.|| ..   
isvanlgakklap.dedlinvttlkvdwaqk.srtiqhlqwenwpdrgvpqinltainllea...........vrydtnpvvvhcsaGvGrsGtivaisl

ATLCSLHGIrrdkHSIMIPLLVREMRRQRICMVQSLAQYEFLYKSIL
     . ||        .  ||.|.| ||   .|. ||| .|.. .|
vqdkmiaGi....nckdmkklveelrsqrhyaiqteaqylylhrvll
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 126-365 1.2e-32 108.0 In-house 12-237 (239) alignment 
Range on Protein: 126-365
Range on HMM: 12-237/239.0
SYEDILPFDHNRVKLK-----CKNDYINASYIKNLLTGAPDFIASQGPTVPTIRSFWEMIAQYKLSVIVMVTNVLEGDLVKCDPYWPEigqtlsfgSNSE
 | .|. .||.|| |.      ..|||||||...       .||.||   ..   || |. | .  ||||.| ..||   ||  |||.        | |.
ryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpd........stsk

FdGSLSVQQLDASDGVAWSRRTFALHYND-EPERRITQFHYTDWPDQGVPASPHSFVQFVRTVmTsqqraQASVAAATpPLLVHCSAGVGRTGTFIGTYA
.   | |    .     .  ||| .       || . |.|.| |||.|||    . . . | . |     . |.  |  | ..||||||||||.|.   |
y.cnlrvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrki.t.....kdslpgar.pwvihcsagvgrtgaflvida

TLCSlhgIRRdKHSIMIPLLVREMRRQRICMVQSLAQYEFLYKSIL
 |      .. .... |   |. .| .|  |||.  || |.. ..|
mlrq...akk.qktvdifnyvkairedrphmvqtseqyvfihlavl
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 127-364 1.7e-32 107.5 In-house 39-255 (267) alignment 
Range on Protein: 127-364
Range on HMM: 39-255/267.0
YEDILPFDHNRVKLKCK-NDYINASYIKNLLTGApDFIASQGPTVPTIRSFWEMIAQYKLSVIVMVTNVLEGDLVKCDPywPEIGQTLSFGSnSEFDGSL
..| ||.|..|| |. | ..||||||..   |.   ||. |.|   ||  |...| ..|..|||..|.| .... .  |  |..||.  .      . ||
lddnlpyddtrvilrtkeeeyinasyvegyktkn.afivtqdplkntitdfltvihdqkvpvivlltkvftdnirlfwP..Pkmgqakkyqd.ltvehsl

SvqqldaSDGVAWSRRTFALHYNDEPERRITQFHYTDWPdqgVPASPHSFVQFVRTVMTSQQraqasVAAATPPLLVHCSAGVGRTGTFIGTYATLcslH
        .   .   |. |....|  . .| ..|  |    . .  . ... .  ... .|     .  . .||.|.||.||||.|||.  .. |   .
e......keendyqiitlelkfknesahnvtlyyykkwn...intnnkpylkplfgilaknq.....lengnrPlvvacsdGvGrsGtflvidsql...e

GIRRDKhSIMIPLLVREMRRQRICMVQSLAQYEFLYKSI
 ....     |  ..|..| ||| .|... .| ......
rakteg.vsdifdflrkirsqriglvdtkeryiyihell
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 126-365 1.9e-32 107.3 In-house 13-238 (239) alignment 
Range on Protein: 126-365
Range on HMM: 13-238/239.0
SYEDILPFDHNRVKLK-----CKNDYINASYIKNLLTGAPDFIASQGPTVPTIRSFWEMIAQYKLSVIVMVTNVLEGDLVKCDPYWPEigqtlsfgSNSE
 | .|. .||.|| |.      ..|||||||...       .||.||   ..   || |. | .  ||||.| ..||   ||  |||.        | |.
ryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpd........stsk

FdGSLSVQQLDASDGVAWSRRTFALHYND-EPERRITQFHYTDWPDQGVPASPHSFVQFVRTVmTsqqraQASVAAATpPLLVHCSAGVGRTGTFIGTYA
.   | |    .     .  ||| .       || . |.|.| |||.|||    . . . | . |     . |.  |  | ..||||||||||.|.   |
y.cnlrvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrki.t.....kdslpgar.pwvihcsagvgrtgaflvida

TLCSlhgIRRdKHSIMIPLLVREMRRQRICMVQSLAQYEFLYKSIL
 |      .. .... |   |. .| .|  |||.  || |.. ..|
mlrq...akk.qktvdifnyvkairedrphmvqtseqyvfihlavl
subfamily_ptpA1_pd Subfamily ptpA1 126-317 2.3e-32 107.3 In-house 52-249 (418) alignment 
Range on Protein: 126-317
Range on HMM: 52-249/418.0
SYEDILPFDHNRVKLKCK-----NDYINASYIKNLLtgAPDFIASQGPTVPTIRSFWEMIAQYKLSVIVMVTNVLEGDLVKCDPYWPE-I-GQTLS-FGS
 | .||| .| ||.||       .||||| ||        .||..|||   ||  || |. . .  .|||..   |   .||| |||| | |. .| .| 
rytnilpvnhtrvqlkkiqdkegsdyinanyidgay..pkqfictqgplpntiadfwrmvwenrcriivmlsresencrikcdrywpeqiggeqfsiygn

NSEFDGSLSVQQLDASDGVAWS--RRTFALHYNDEpERRITQFHYTDWPDQGVPASPHSFVQFVRTVMTSQQRAQASVaAATPPLLVHCSAGVGRTGTFI
  |  |. ||. ..  .        |   | .. |  | |||..|  |||. .|   . | |.....   |..   |      |..||||||||||||| 
gnevfgtysvelveviqdpereiitrnirltfege.trditqyqyegwpdhnipdhtqpfrqllhsitnrqnqiipss.drnvpiivhcsagvgrtgtfc

GT
 .
ta
0051082 (Phosphotyrosine protein) phosphatases II 144-363 9.7e-32 105.0 In-house 3-148 (151) alignment 
Range on Protein: 144-363
Range on HMM: 3-148/151.0
NDYINASYIKNLltgapdFIASQGPTVptirSFWEMIAQYKLSVIVMVTNVLEGDlvKCDPYWPEIGqtlsfgsnsefdgslsvqqldasdgvawsrrtf
.||||.||. .       ...|.||.      |.|.........||....  | .  .|  |.|| |                                 
sdyinfsyvtgg......lyrsggpla....dflellkelgiktivnlrseeerg..ycpeylpelg.................................

alhyndepeRRITQFHYTDWPDQGVPASPHSFVQFVRTVMTsqqraqasvaAATPPLLVHCSAGVGRTGTFIGTYATLCSlhgirrdkhsIMIPLLVREM
         .........||||.|.| |......|.. ..               |.|||||||.|||||... |  |.           . .   ..|.
.........ievlhipildwpdpglplsfdavleflellld..........kkngpvlvHCsaGkgRTGtlvalylmllg..........vsleealeey

RRQRICMVQSLAQYEFLYKS
|..|  .||.  |. |... 
rlkrpgvvqpnqqflfqlfa
0049772 (Phosphotyrosine protein) phosphatases II 122-372 5.8e-31 103.8 In-house 47-284 (314) alignment 
Range on Protein: 122-372
Range on HMM: 47-284/314.0
LRACSYEDILPFDhNRVKLKC----KNDYINASYIKNLltgaPDFIASQGPTVPTIRSF----------WEMI--AQYKLSVIVM---------------
    .| ||||.| |||.|.       |||||||...      .|||.|||.  |. .|          |.|.   .... .|||               
rdknryldilpad.nrvilpglpvsgsdyinasyvdgf....lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivmsrdevladelsrLda

------VTNVLEGDlvkcdpywpeigqtlsfgsnsefdgslsvQQLDASDGVAWSrrtFALHYNDEPERRITQFHYTDWPDQGVPaSPHSFVQFVRTVMT
       ... ..                               ...|.|   .      |. .. .||.. .......|| ..| ..  | .|.. . .
AlgKtpllildgng.............................neptaadlellk...eelydpelferlgikylripvpDgsap.lledfdeflefiee

SqqraQasvaaATPPLLVHCSAGVGRTGTFIGTYAtLCSLHGIrrDKHSImipllVREMRRQRI-----CMVQSLAQYEFLYKSILIAIDEYM
     .     .  |.||||.||.||||||. ..  |..|.|.  . . .     ....|..|       ....| |||| .. .| ... ..
a....d.....kggpvlvHCkaGkgRtgtfvvaay.lmkllgv..sleea.....ledvrlkRpinpnpgfieqleqyefilealleylkflk
subfamily_CG7180_pd Subfamily CG7180 128-365 8.1e-31 101.7 In-house 49-287 (296) alignment 
Range on Protein: 128-365
Range on HMM: 49-287/296.0
EDILPFDHNRVKLK-----CKNDYINASYIKNLLTgAPDFIASQGPTVPTIRSFWEMIAQYKLSVIVMVTNVLEGDLvKCDPYWPEIGqTLSFGSNSefD
 ...|.|.||| |.      |.|||||.|.  .|    ..|  ..|.  |. .||... . . | .|..|.. .    ..  |||. .    .|      
vkvvPyDynRvvLekldGeeksdYinavyvdsflk.kkeyivteapkketvdefWrlvydeeisavvvLtktfdfak.mypsywpnks.keqygeif..v

GSLSVQQLDA--SDGVAWSRRTF----ALHYNDEPERRITQFHYTDWPD-QGVPASPHSFVQFVRTVMTSQQRAqaSVAAATPPLLVHCSAGVGRTGTFI
  ....|. .  .  .   ..        .  . ..| ...|..| |.  . || |  ......| | . ....       . |..|..| |..|.| ..
eiveekqyanlkirtfkltkkivalteqekqvkaetRivklfqlteWeledkvPlstnalielrrrvrlwrekv..dedpeegPvvvvssdGasRsGvyl

GTYATLCSLhgirRDKHSIMIPLLVREMRRQRICMVQSLAQYEFLYKSIL
.  |.|  .    . .. . .   |. .||.|  .|..  .| ..|  .|
aidanlelv....ekeeevdvFeavktlrrsRpqLvenveeYkyiYdvll
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 124-365 1.1e-30 101.2 In-house 59-280 (290) alignment 
Range on Protein: 124-365
Range on HMM: 59-280/290.0
ACSYEDILPFDHNRVKLK--CKNDYINASYIKNLltgAPDFIASQGPTVPTIRSFWEMIAQYKLSVIVMVTNVLEGDLVKCDPYWPE-IGQTLSFGSNSe
   | |.   |  || ||   . ||. | |.| |    . || .||..  |.  .| |. | | ..|||. ...|    ||..|.||  |..|.||. . 
knrykdvvcndktrvilkdGydGdyvhanyvkGl...kamfiltqGalkdtvidiwrmvlqekvaaivmlceliedGkakceqyypekeGevltfGeit.

fdgsLSVQQLDASDGVAWSRRTFALHYNDEPERRITQFHYTDWPDQGVPASPHSFVQFVRtvmtsqqraqaSVAAATPPLLVHCSAGVGRTGTFIGTYAT
    .   . |  |     .     . ..  | ..  ..   |||. |. |  .... .|           ..  |. |. ||||||.||||||.   ..
....vlcseeddkdaniikktlsvrdkdsGkehklkhlkikswpdksvalstlallrtlr...........ilrkasGpvvvhcsaGiGrtGtfvaievg

LCSLhgirRDKHSIMIPLLVREMRRQRICMVQSLAQYEFLYKSIL
|  |     | ... .  ||| .|. |.  ||   ||  | . .|
lqil....ldGkeldlldlvralrnsrlnsvqvdiqylalveill
0049260 (Phosphotyrosine protein) phosphatases II 161-362 3.7e-30 100.0 In-house 10-144 (152) alignment 
Range on Protein: 161-362
Range on HMM: 10-144/152.0
DFIASQGPTVPTIRSFWEMIAQYKLSVIVMVTNVLEGDLVKCDPYWpeigqtlsfgsnsefdgslsvqqldasdgvawsrrtfalhyndeperritQFHY
 ||| |||.  |. .||.|. ... ..|||.|. || . .||. |.                                                  |...
efiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi..................................................qylh

TDWPDQGVPASPHSFVQFVRTVMTSQQRAQAsvaaatpPLLVHCSAGVGRTGTFIGTYATLcslhgirrdkHSIMIPLLVREMRRQRICMVQSLAQYEFL
. ||| ||| ..  . .... .   ... .        | |||||||||||||..  |  |          . . .   |. .|..| ..|..  |..||
lpwpDhgvpdlsqlllflllfieklaldkgg.......pvlVHCsaGvgRtgtlvaaylml..........lgvsleeavalvrekRpgavpnpgqlrfl

YK
|.
ye
PTPc_DSPc_SM00012 255-365 1.9e-29 97.3 In-house 2-104 (105) alignment 
Range on Protein: 255-365
Range on HMM: 2-104/105.0
ITQFHYTDWPDQGVPASPHSFVQFVRTVMTSQQRAQAsvaaaTPPLLVHCSAGVGRTGTFIGTYATLCSLHGIRrdkHSIMIPLLVREMRRQRICMVQSL
....|||.|||.||| ...|.....| |..... ..      ..|..|||||||||||||.  .  |..|.  .   ... |  .|.|.|.||  |||..
vkhyhytgwpdhgvPeesdsilellravkknknkses.....skpvvVhCsaGvgRtgtfvaldillqqleket...kevdifqivkelrkqRpgmvqte

AQYEFLYKSIL
.|| |||. .|
eqylflyrall
0044763 (Phosphotyrosine protein) phosphatases II 132-362 3.6e-29 97.0 In-house 1-165 (178) alignment 
Range on Protein: 132-362
Range on HMM: 1-165/178.0
PFDHNRVKLKCKND-----YINASYIKnlltgaPDFIASQGPTvptiRSFWEMIAQYKLSVIVMVTNVLEGDLVKCDPYWPEIGQtlsfgsnsefdgsls
|.|..||.|    .     |||||.|       |...... |.     ...|.. ......||..|. ||.  .||||||||                  
pldrtrvllsnleglersdyinaseil......pglylgslpp....addlellkelgithivnlteelelgflkcdpywpeeag...............

vqqldasdgvawsrrtfalhyndeperriTQFHYTDWPDQGVPASPHSFVQFVRTVMTSQQRAQasvaaatPPLLVHCSAGVGRTGTFIGTYATLCSlhg
                              |.... .|| ||| ..  | .||. . . ... .        | ||||||||||.||..  |  ..    
.............................iqylhipipDhgvpdllehflefvefieealdekg.......gpvlVHCsaGvgRsgtlvaaylmkkl...

irrdkhSIMIPLLVREMRRQRIcMVQSLAQYEFLYK
      .. ..  ....|..|  .|..  |...||.
......glsleeaielvrerRp.ivpnpgqlrqLye
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 126-366 6.7e-29 95.5 In-house 60-287 (305) alignment 
Range on Protein: 126-366
Range on HMM: 60-287/305.0
SYEDILPFDHNRVKLK--CKNDYINASYIKNLLTGAPDFIASQGPTVPTIRSFWEMIAQYKLSVIVMVTNVLEGDLVKCDPYWPE-IGQTLSFGSNSEFD
 |.|.   |.. |||.     ||| | |.   .     ||..|||   ||  || |. | |.  |||. . .|   .||  |||   |. |.. |    .
ryqdvpcqdqsavkldkpspsdyihanyvgcpmipekrficaqgpldqtidefwwmviqnkveqivmlcktvelgklkcaqywpaaqgeklelksgivve

GSLSVQQLDASDGVAwsRRTFALHYNDEPERRITQFHYTDWPDQGVPASPHSFVQFVrtvmtsqqraqASVAAATPPLLVHCSAGVGRTGTFIgtyATLC
     . ..    .     .. | |. . .  . ....|.|||.|||    . ....           ...  .  |..||||||.||||| .   |   
nvsgskpmerdaeiq..itllnltysgdqkmsvrhlqwtewpdrgvppckltslell...........sairgskvpivvhcsagigrtgtiv...aiey

SLHGIRRDKHSIMIPLLVREMRRQRICMVQSLAQYEFLYKSILI
 |  |  .|.   .| ||. .| ||   .|.  || |... .| 
ilekiaenkpcppmpelvkalrdqrafsiqndvqylfihrvmln
subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 126-364 1.1e-27 91.8 In-house 40-266 (285) alignment 
Range on Protein: 126-364
Range on HMM: 40-266/285.0
SYEDILPFDHNRVKLKCK-NDYINASYIKNLLTGAPDFIASQGPTVPTIRSFWEMIAQYKLSVIVMVTNVLEGDLVKCDPYWPE-IGQTLSFGsnsEFDG
 | |.   .  || || .  ||| ||...        .|..|||   |.  || || | |.. ..|.  ..|| . ||  |.|| .|. . ||   ... 
ryadvrcieetrvvlknhdrdyihaswmrmpgkdqstyittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekcalyypeklgevvkfg...kyei

SLSVQQLDASDGVAWSRRTFALHYNDEPER-RITQFHYTDWPDQGVPASPHSFVQFVRTVMTsqqraqasVAAATPPLLVHCSAGVGRTGTFIGT-YATL
.|.  . .|  |  .   |     .   |   . . .   ||||  |   . .... . |          |     |. |||||||||| ||.|  |||.
tlteckeeaiagtilnaltvintedasseplymnhvqvpwwpdqlapedarpmielykwvkk........vnpkekpicvhcsagvgrtatfvgidyati

CSLhgirrDKHSIMIPLLVREMRRQRICMVQSLAQYEFLYKSI
  .     ..  | .  .|||||  |.  |||  |. |||  .
rim.....enpniemldivremramrfqavqshmqflflyvvl
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 126-366 1.4e-26 88.0 In-house 53-285 (305) alignment 
Range on Protein: 126-366
Range on HMM: 53-285/305.0
SYEDILPFDHNRVKLKC--KNDYINASYIKNlLTGAPDFIASQGPTVPTIRSFWEMIAQYKLSVIVMVTNVLEGDLVKCDPYWPE-IGQTLSFGSNS---
 | |.  .|.|||||.     .|| | |.    | .  || .| |   |   || |  | |.  | |. |.||    ||  |..   ...|.|  .    
rykdvgcldnnrvklegpwpheyihanyvst.ptnpkrfictqaplektcadfwymclqdkveaifmlcnllekgakkcleyfaskdkdvlefeekgqki

--EFDGSLSVQQLDASDGVaWSRRTFALHYNDEPERRITQFHYTDWPDQGVPASPHSFVQFVRtvmtsqqRAQASvaaaTPPLLVHCSAGVGRTGTFIGT
   |. | ...  . .. .  ..  . .    |  |..|..|. ||||.||||.  . ....        .|..|      |. ||||||.||||. .  
svkfessvtlkfrkdakak.vtetvlviegpgekarkvthyhwidwpdrgvpaadlailelle.......karps....kgpivvhcsagigrtgsvvml

-YATLCSLHGIRRDKHSIMipllVREMRRQRICMVQSLAQYEFLYKSILI
 |     | |   ..   .    .. .| ||   .|. ||| |... || 
eyildqllagqiiedtdki....lqkireqrnnsiqtdaqylfvhqviln
subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 126-365 9.5e-25 81.8 In-house 42-266 (281) alignment 
Range on Protein: 126-365
Range on HMM: 42-266/281.0
SYEDILPFDHNRVKLKC------KNDYINASYIKNLLTGaPDFIASQGPTVPTIRSFWEMIAQYKLSVIVMVTNVLEGDLVKCDPYWPEIGQTlsfgsNS
 | .|  .|  ||.||         ||| | ||.  .     .| .|||   |   || || | . . |||. ..|| .  ||  |.|   .        
rylnipcldisrvqlkvkmpnknstdyihanyirspflk.rgyiltqgpkketradfwrmiwqenttaivmlcqfletnrekcaeyfprnahc.....cl

EFDgSLSVQQLDASDGVAWSRRTFALHYNDEpERRITQFHYTDWPDQGVPASPHSFVQFVRTVmtsqqRaqasvAAATPPLlVHCSAGVGRTGTFIGTYA
.||  |||.  |..   .     . | |. |  | ||.. . .|||  || |   ... .| .     |     | .|||. .||||||||.||..    
qfd.klsvsyedstvnkslvttrlnlsyege.trlithwlwkewpdwqvpessevmlkilrki.....r.....arstppv.ihcsagvgrsgtlmavei

TLCSLHGIRRDKHsimIPLLVREMR-RQRICMVQSLAQYEFLYKSIL
.| |.|          |  .|  .|   | . ||.| || ...| .|
alqsihshftlpd...ikqivshlrvtgraasvqtlqqymliwkvll
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 127-365 5.9e-24 79.6 In-house 49-268 (288) alignment 
Range on Protein: 127-365
Range on HMM: 49-268/288.0
YEDILPFDHNRVKLKCKNDYINASYIKNLLTGAPDFIASQGPTVPTIRSFWEMIAQYKLSVIVMVTNVLEGDLVKCDPYWP-EIGQTLSFGSNsefdG-S
||..   |  ||||.   |.  |. .         .| .| |   ||  .|.|. .  .  |||....||  . | . |.| ..|..  .| .       
yenlprcditrvklsddpdfyiaanvvssakykrrlicaqaPlngtieelWkmllesdveyivmlcellekGkeksaeyfPsklGekarigrl....ctv

LSVQQLDASDGVAWSrrTFALHYNDEPERRITQFHYTDWPDQGVPASPHSFVQFVRTVmtsqqraqasvAAATPPLLVHCSAGVGRTGTFIgtyATLCSL
  ... |    |  |  ..  . . | .  . . |. .|.|.||| .  |.....  .            . . |..||.|||||||||.|    .|  |
vkkkradidklvkvs..llriskegeekvivkilhlleWdddgvPenylsplrllevl...........kslqkPivvhssaGvGrtgtli...lilial

HGIRRDKhSIMIPLLVREMRRQRICMVQSLAQYEFLYKSIL
. .| |   . |. |. ..| .|   .|.  || .... .|
eslrldd.flgirsllaklreerfkaiqtemqylyvhrcvl
subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 125-367 4.1e-23 76.4 In-house 56-289 (310) alignment 
Range on Protein: 125-367
Range on HMM: 56-289/310.0
CSYEDILPFDHNRVKLKC----KNDYINASYIKNLLTgAPDFIASQGPTVPTIRSFWEMIAQYKLSVIVMVTNVLEGDLVKCDPYWPEIGQTLSFGSNSE
  | |..  |  |||||      .||| | |.|        || ||||   ||  || || | .   |... .| |    ||  ||| .| | ..|    
nrysdvvcldtsrvklkidksryedyihanyvktnyl.rstficsqgplqhtiidfwrmifqeraesilllckvgeegrpkcvgywpslgvtetygcirv

FDGSLSVQQLDASD-GVAWSRRTFALHY--NDEPERRITQFHYTDWPDQGVPASphsfvqfvrTVMTSQQRAQASVAAAtpPLLVHCSAGVGRTGTFIgt
 . | | ....  .  |..      .     .  | |..  .. .|||.|||            . |  ||  | |     | .||||||..|... .  
tnlsesseefeicnlavtfvpdnvpvdeqpanlkelrvslikwpnwpdrgvpde.........kchtvpqrllaqvrhg..pcvvhcsagkdrlyvvv..

yATLCSLHGIRRDkHSIMIPLLVREMRRQRICMVQSLAQYEFLYKSILIA
 |   ... ..|  . . .  .. |....|.  .|.  || .. .  .| 
.alklkidkldrg.lkvdaeevktellksraiciqtelqyliidrvriif
subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 149-357 6.8e-22 72.6 In-house 80-270 (301) alignment 
Range on Protein: 149-357
Range on HMM: 80-270/301.0
ASYIKNLltGAP-DFIASQGPTVPTIRSFWEMIAQYKLSVIVMVTNVLEGDLVKCDPYWPE-IGQTLSFGsnsEFDGSLSVQQLDASDGVawSRRTFALH
| .|.    | |  |||.|||   |   || |. ||..  |||... .|    ||. | |  |...|  |    |.  .  ..|  .. .  |.||. ..
anwipts..GhphrfiatqgPlkntsedfwamlvqydvekivmlgqkvekleekceeylpvkisekldig...rfkikiknkelilnkki..skrtleve

Y--NDEPERRITQFHYTDWPDQGVPASPHSFVQFVRTVMTSQQraqasvaaatpPLLVHCSAGVGRTGTFIGTYatlCSLHGIRRDKhSIMIPLLVREMR
   .. . | .| . |..|.|.||| |     ...  |  |..           |..||||||.||. .||||    .  . .  |.  | .   ....|
dstgkfatrtvthyqysewtdrgvPkshaelfdlmelvkksek...........PivvhcsaGiGrsvafigte...ylareveadp.tieltealkhlr

RQRICMVQSLAQY
 .| . ||   | 
ehrwngvqtnsql
0048076 (Phosphotyrosine protein) phosphatases II 246-362 1.8e-21 71.8 In-house 38-137 (145) alignment 
Range on Protein: 246-362
Range on HMM: 38-137/145.0
HYNDEPERRITQFHYTDWPDQGVPASPHSFVQFVRTVMTSQQRaqasvaaaTPPLLVHCSAGVGRTGTFIGTYATLCslhgirrdkHSIMIPLLVREMRR
.. . .|| ..|..|..||| ||| ..  . .|.. . . ...          | |||||||||||||... |  |.         ... ..  ....|.
selellerlgiqylylpwpDhgvpdllellleflefieealke........ggpvlVHCsaGvgRtgtlvaaylmll.........lgvsleealelvrs

QRICMVQSLAQYEFLYK
|| ..|..  |..|||.
qrpgavpnpgqlrflye
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 126-210 4.3e-20 66.7 In-house 52-154 (350) alignment 
Range on Protein: 126-210
Range on HMM: 52-154/350.0
SYEDILPFDHNRVKLK-------------CKNDYINASYIKNL---LTGAPDF--IASQGPTVPTIRSFWEMIAQYKLSVIVMVTNVLEGDLVKCDPYWP
 |..|||..|.|||||               ||||||.|.|         |||  || |.|.  |.  |...| . |  ||...|.  | .| ||. ||.
rYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvkvilsltsdvelnlekcyrYWq

EIG
| .
egs
0048179 (Phosphotyrosine protein) phosphatases II 246-362 5.9e-20 66.9 In-house 40-139 (144) alignment 
Range on Protein: 246-362
Range on HMM: 40-139/144.0
HYNDEPERRITQFHYTDWPDQGVPASPHSFVQFVRTVMTSQQraqasvaaATPPLLVHCSAGVGRTGTFIGTYATLcslhgirrdKHSIMIPLLVREMRR
......|| ..|.....||| ||| ... . .|.. . . ..           | |||||||||||||..  |  .         |. . .   ....|.
yepefleregiqylhlpwpDhgvpdllellleflefieeale........eggpvlVHCsaGvgRtgtlvaaylmk.........klglsleealalvrs

QRICMVQSLAQYEFLYK
.| ..|..  |..||..
rrpgavpnpgqlrfLle
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 255-365 6.1e-19 62.9 In-house 217-341 (350) alignment 
Range on Protein: 255-365
Range on HMM: 217-341/350.0
ITQFHYTDWPDQGVPASPHSFVQFVR---TVMTSQQRAQASVAAATPPLLVHCSAGVGRTGTFIGTYATLC---SLHGIRRD--------KHSIMIPLLV
. |...  |.| ..   |.|..| .     .. .    . .  | ..|.|||||||||||||..     |     |. ....        |   .|  .|
vyqlqvknWkDlslllnPesilqalevkndliddlfaeshldnarsspilvhCsaGvGrtGtlvtlDsllsdfeilenltkesrkldvaaktrDlisiiv

REMRRQRICMVQSLAQYEFLYKSIL
 |.|.||| |||.| |. |.|...|
nelrkqrismvqnldqfifiYeall
subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 168-363 4.1e-17 56.6 In-house 99-283 (302) alignment 
Range on Protein: 168-363
Range on HMM: 99-283/302.0
PTVPTIRSFWEMIAQYKLSVIVMVTNVLEGDLVKCDPYWP-EIGQTLSFGSNSEFDGSLSVQQLDASDGVAWSRRTFA---LHYNDEPERRITQFHYTDW
|   |.  .| .| ||. ...| .... |..  || .|.  ..|..| ||  .    |.  .  . .|  .    |      . ... .. .  .... |
pkkstlekhwalieqynvaivvqlcsfvedeekkcaeyysdkvggelkfgrytvktvsvktdleeftdkksfklytveiknekkkkkvkktvdilafsaw

PDQGVPASPHSFVQFVRTVMTSQQRaqasVaaatpplLVHCSAGVGRTGTFIGTY--ATLCSlhgirRDKHSIMIpLLVREMRRQRICMVQSLAQYEFLY
|| | |. ... .. ..   . ..     |       |||||||||||||..       |||     ..| . .. ..|  .|. |   ||.  |  .| 
pdhGapkeaytaldilkfcesykkn....v.......lvhcsaGvGrtGtlvaikyGiqlcs.....kkkvtdll.sivlpvrqcryGavqdeqqliyll

KS
  
lc
subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 127-364 7e-17 56.0 In-house 53-275 (303) alignment 
Range on Protein: 127-364
Range on HMM: 53-275/303.0
YEDILPFDHNRVKLKcKNDYINASYIKnlLTGAPDFIASQGPTVPTIRSFWEMIAQYKLSVIVMVTNVLEGDLVKCDPYWPEIGQTLSFGSNSEFDGSLs
. |.. .|| .|||     || |||..  |      | .| |   |   ||.|| . |. .....    | | .  |  .|.  . | |   |   | . 
fvdvicldhskvkls.dssyihasyle..ldsskkailtqlplshtaadfwqmiieqkvkcvlllltdseydklggdsvfprnqdflkfeersirvgef.

vQQLDASDGvaWSRRTFALHyNDEPERRITQFHYTDWPDQGVPASPHsfVQFVRTVMTSQQRAqASVAAATPPLLVHCSaGVGRTGTFIGTYATLCSLHG
 .... .||  |. .  ..  | .    .   || .|| . .|.      .||. .   |       . .||.. .  | |.||.|||    ..  ||| 
.krvelgdg..wvlkvlsvs.ngdyksflhvhhykawphnsipsdgs..pkfvkqiwqlqsvl.rkysdstptvymsls.gcgragtfalfetahlslhs

irrDKHSIMIPLLVREMRRQRICMVQSLAQYEFLYKSI
   .. |. .   .  .|  |.  || |.|. ..|  .
...eqasldlvkclenvrngrlhavqnlsqfsvvytll
subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 142-373 1.6e-16 55.3 In-house 44-264 (290) alignment 
Range on Protein: 142-373
Range on HMM: 44-264/290.0
CKNDYINASYIKnlLTGAPDFIASQGPTV-------PTIRSFWEMIAQYKLSVIVMVTNVLEGDLV----KCDPYWPE-IGQTLSFGSnsefdGSLSVQQ
 ..||| |....        .|..| |          || .|| |. | |   .||. .. | .       |  | || .|. | |.       ... ..
fnddyiHAnrvt..cpnglrliltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCakYvpesvgeelkfkg.....ltvkCks

LDASDGVawSRRTFALHYNDEPERRITQFHYTDWPDQGVPASPHSFVQFVRTVMTSqqraqasvaaaTPPLLVHCSAGVGRTGTFIGTYatLcSLHGIRR
  . |.|   .|.  ....|| |  .|   . .| .  |. .. .... ...|..|           . | .|||  |. |  ..      | .   |  
kekeddv..etRelvvkfddeeeftvtHsllkgWnklnvqedtktllsliqkvkas...........ktpvivHcvdGiSrsAalaaii..l.gyQkiae

DKHSIMIPLLVREMRRQRICMVQSLAQYEFLYKSILIAIDEYMR
 ..|. .  .. ..|.||  ...|  .. |    |.. . | ..
tsgsvkledvlkalrkqralaitsalelafvdagivllaievld
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 233-366 5.9e-16 52.8 In-house 69-192 (440) alignment 
Range on Protein: 233-366
Range on HMM: 69-192/440.0
SDGVAWSRRTFALHYNDEPERRITQFHYTDWPDQGVPASPHSFVQFVRTVMTSQQRAqasvaaATPPLLVHCSAGVGRTGTFIGTYATLCSlhGIRRDKh
  ||  |    | . |    | . |.||  |||.|||      ..... |  ||..|      .  |||||||||.||||  |   . |      | |. 
vkgvpdsdyinasyingiesrtlkqyhyqgwpdkgvpkfagpvlkmiqdvnesqeka......gngpllvhcsagagrtgviiavdsilre..akrsdq.

sIMIPLLVREMRRQRICMVQSLAQYEFLYKSILI
 | |  ..  || .|  |||.  || |.....| 
.idifsfinsmrnnrpqmvqtpeqyafvheavle
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 254-365 6.1e-16 52.7 In-house 219-341 (349) alignment 
Range on Protein: 254-365
Range on HMM: 219-341/349.0
RITQFHYTDWPDQGVPASPHSFVQFVR--TVMTSQQRAQA-SVAAATPPLLVHCSAGVGRTGTFIGTYATLCSLHGIRRDKHSI--------MIPLLVRE
 . |. . .|.| ..   | |..| .     .  .. |.    .. ...|||||||| ||||...     |  |.  ...   |        .| . | |
ellqlqvknwldlslllnPisilqalevkndliddlfarlyldtdqlstllvhcsaGcGrtGvlvtldlllsileplqnesnkiklqallkDlisiivne

MRRQRICMVQSLAQYEFLYKSIL
.|.||| ||| |||. ..|...|
lrkqrismvqnlaqfiaiyealL
subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 127-366 1.3e-15 52.0 In-house 49-274 (312) alignment 
Range on Protein: 127-366
Range on HMM: 49-274/312.0
YEDILPFDHNRVKLKC-KNDYINASYIKnLLTGAPDFIASQGPTVPTIRSFWEMIAQYKLSVIVMVTNVLEGDLVKCDPYWPEIGQTLSFGSNSEFDGSL
| .|  .|  |  |   .| || | ..| . |    |...|||   |.  ||..      . |.... ..|    ||  |  .|   . .     .  . 
ypniqcwdrgrftlagdenfyihanfvk.ictkperfvctqgplentcthfwqlalslgstsiillcgfvedgsekcakyisdivgfvdledhrvyteyc

SVQQLDASDGVAWSRRTFA-LHYNDEPERRITQFHYTDWPDQGVPASPHSFVqfvrtvmtsqqRAQASVAAATPPLLVHCSAGVGRTGTFIGTYATLCSL
.  ..        . | .  .      | .. .. .. |||.|.| |  .             |  ..|     |.. |||||||||||..   . ...|
teieiggkskdkithrvlkvvvkatgqesklnhyqwaswpdhgmpdscdtal...........rllsavkkdkkpviahcsagvgrtgtlaliesmiaal

HGIRRDKHSIMIPLLvremRRQRICMVQSLAQYEFLYKSILI
   |...   .  ||    |..|   |. ..|| .  ...| 
rhprkqnvkdsfvll....rkdrarsvrvfpqyvyalrcvle
subfamily_egg_pd Subfamily egg 134-379 2.5e-15 51.0 In-house 53-281 (307) alignment 
Range on Protein: 134-379
Range on HMM: 53-281/307.0
DHNRVKLKCKN-----DYINASYIKnlltGAP---DFIASQGPTVPTIRSFWEMIAQYKLSVIVMVTNVLEGdlVKCDPYWPEIGQTlsfgSNSEFDGSL
|  ||||. ..     |.| | ..|    | |   .|| .| |   |   || |. | .   |||.|   |    .|. |||   .     |     |||
dssrvklelrrGqylddfihanrvk....Gkpllnefilaqaplkntvddfwrmvfqeevqyivmltsrkes..erceyywpkaesd....slvtvpGsl

SVQQLDASDGVAWSRRTF--ALHYNDEpERRITQFHYTDWPDQGVPASPHSFVQFVRtvmtsqqraQASVaaatpPLLVHCSAGVGRTGTFIGTYATLCS
 .. |.  .      |     |   |. | |  .    |.   .   ||   .. .|         ..|      | .|..  || ...|..    .|.|
rienlkvdskadplfrvtklklvGgdd.eerflehwqgdvnnssdvysplrvlrklr.........nlsk.....pvvvqdilGvskaatlvaieialls

LhgIRRDKHSIMIPLLVREMRRQRICMVQSLAQYEFLYKSILIAIDEYMRSARGMQ
|  .|      ..   |  .|..|   |.|  .| |.|. .|. . . . ||. ..
l..lrGpitkslvlravvflrlrrrlsvesvllylfvyrlvlfffrdvigsakeld
subfamily_CG42327_pd Subfamily CG42327 296-364 7.6e-15 49.4 In-house 246-311 (319) alignment 
Range on Protein: 296-364
Range on HMM: 246-311/319.0
ATPPLLVHCSAGVGRTGTFIGTYATLCSLhgiRRDKHSIMIPLLVREMRRQRICMVQSLAQYEFLYKSI
   || |||| ||||||. | .  .. ||      |.|. || ||  .||.|   |..  ||||.|| .
sqGPlvvhcsdGvGrtGlviasdiairsl...eeskrsvdiPqlvssvrrdrasavltkeqyefiykvl
subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 124-375 1.1e-14 48.5 In-house 54-292 (302) alignment 
Range on Protein: 124-375
Range on HMM: 54-292/302.0
ACSYEDILPFDHNRVKLK-CKNDYINASYIKNLLTGaPDFIASQGPTVPTI---RSFWEMIAQYKLSVIVMVTNVLEGDLvKCDPYWP-EIGQTLSFGSN
 .  ||.   |.|.|||. ....|.||| ..    . .  | .| |.| .     .|| |..| |   .|..    | .    . ..| . |. . .|. 
knqsedvpildsnlvkleaepdsyvnaskvevPelt.rsiilaQlpkvdsedsveeFWrmvfqekivsvvilvgeeelkk.tlselfpkksgdykeygkm

sefdgSLSVQQLDASDGVAwSRRTFALHYNDEPERRITQF-HYTDWPDQGVPASPHSFVQFVRTVmtsqqraQASVAAATPPLLVHCSAGVGRTGTFIGT
      . ... . ... . .| .  .  ..  .  ...  . | |... || .  . .. .  |        |. . |. ....    |.|| |.|.  
.....fvNnrkVekaeeek.tryviEvlPegcsnsvlanvyvltnWkqkkvpvkyaeliktaakv.......fakkikadentvivSknGaGRagafltl

YATLCSLHgirrDKHSIMIPLLVREMRRQRICMVQSLAQYEFLYKSILIAIDEYMRSA
 .....|.    ...   |  .|. .| || ..|.|| || .|| ..|. | . ... 
avaveklq....kgkepnikeivksiRsqRpravdslkQyvslyialllyikkkvtkp
subfamily_CG42327_pd Subfamily CG42327 140-285 5e-14 46.7 In-house 52-193 (319) alignment 
Range on Protein: 140-285
Range on HMM: 52-193/319.0
LKCKNDYINASYIKNLLTGAPDFIASQGPTVPTIRSFWEMIAQYKLSVIVMVTNVLEGDLVKCDPYWPEIgQTlsfGSNSEFDGSLSVQQLDASDGVAWS
 . |. |..|||..        .||.| .   .  .|| .. . .  ||| .|.. |  . .|  |.|   .|   . | .  | . |   .   .  . 
dddkdeyldasyvrGyddapnsyiaaqvsledsssdfwrtvweqqsrvivqltdlselGikvcaeylPtk.et...ldntslyGdilvtlkgrevkdrya

RRTFALHYND-EPERRITQFHYtDWPDQGVPASPHSFVQFVRTVMTS
  |. |.  | |  | .| . | .|.. .|||.. ...  .  | .|
istlllkrvdkeesrelthywy.kwleaevPaeeaaliamllevrss
subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 161-362 1e-12 42.6 In-house 5-197 (198) alignment 
Range on Protein: 161-362
Range on HMM: 5-197/198.0
DFIASQGPTVPTIRSFWEMIAQYKLSVIVMVTNVLEGDLVKCDPYWPEIGQ-TLSFgsnsefdGSLSVQQLDASDGVAWSRRTFALHYND---EPERRIT
 .||.| |   |.  ||.|. .     |||| .      .    |||     |  .       |||||     .    ..  .. |  |       | |.
ryiatqhplretladfwqmvwetgsghivmvnddqknkeadypfywpttesgtgky.......gslsvttktittkpdytitaliltnnttappstreis

QFHYTDWPDQGVPASpHSFVQFvrtVMTSQQRAQASVAAATPPLLVHCSAGVGRTGTFIGTYATLCSlHgiRRDKHSIMIPL-LVREMRRQRICMVQSLA
.. .| | ..  |     || |   |..|.. ..        |..|||| | | || |.     . | |     | |..  . . . .|. |  .. || 
hyqftswkekttpnv.alfvgf...vvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrs.h..eesktsvvdlfevakrlrqarcgiisslq

QYEFLYK
.|.|.|.
hynfiyq
subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 160-362 1.1e-12 42.6 In-house 5-198 (199) alignment 
Range on Protein: 160-362
Range on HMM: 5-198/199.0
PDFIASQGPTVPTIRSFWEMIAQYKLSVIVMVTNVLEGDLVKCDPYWPEIGQ-TLSFgsnsefdGSLSVQQLDASDGVAWSRRTFALHYND---EPERRI
  .||.| |   |.  ||.|. .     |||| .      .    |||     |  .       |||||     .    ..  .. |  |       | |
rryiatqhplretmadfwqmvwetgsghivmvnddqknkeadypfywpttesgtgky.......gslsvttktittkpdytitaliltnnttappstrei

TQFHYTDWPDQGVPASpHSFVQFvrtVMTSQQRAQASVAAATPPLLVHCSAGVGRTGTFIGTYATLCSlHgiRRDKHSIMIPL-LVREMRRQRICMVQSL
... .| | ..  |     || |   |..|.. ..        |..|||| | | || |.     . | |     | |..  . . . .|. |  .. ||
shyqftswkekttpnv.alfvgf...vvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrs.h..eesktsvvdlfevakrlrqarcgiissl

AQYEFLYK
 .|.|.|.
qhynfiyq
subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 172-366 2.6e-12 41.4 In-house 40-177 (255) alignment 
Range on Protein: 172-366
Range on HMM: 40-177/255.0
TIRSFWEMIAQYKLSVIVMVTNVLEGDLVKCDPYWPEI-GQTLSFgsnsefDgSLSVQQLDASDGVAWSRRTFALHYN-DEPERRITQFHYTDWPDQGVP
|.  |...| | | .|.||...  | . .||. |.|    . | .         ..|   ..|  |    ..  ...      . .. ..|. |...  |
tvdkfyqtivqtktevvvmlcdfaeegvekcssyfplekdeklkl......a.dvnvtttkssadvvlrtleitstlgekkkthtvkhysykGWieknaP

ASPHSFVQFVRTVMTSQqraqasvaaatpPLLVHCSAGVGRTGTFIgtyatlcslhgirrdkhsimipllvremrrqricmvqslaQYEFLYKSILI
  ..   . .. |  |.            ...||||.|.||. .|.                                          |..|. .. 
elareilnilkvvrdsk............svvvhCstGiGrsaafv........................................laelvyqkmir
subfamily_hpo-7_pd Subfamily hpo-7 170-359 8.8e-10 32.9 In-house 44-218 (263) alignment 
Range on Protein: 170-359
Range on HMM: 44-218/263.0
VPTIRSFWEMIAQYKLSVIVMVTNVLEGDLVKCDPYWPE-IGQTLSFgSNSEFDGSlSVQQldasDGVAWSRRTFALHYNDEPERRITQFHYTDWPDQGV
| || .|...| | | .|.||...  | . .||. |.|    . . .  | .   .  ||.    | .  ..       .    . .... |. |...  
vqtidkfyqtivqtktevvvmLcDfneegvekcssyfPlekdekqkl.anvnvctt.kvqs....dvllktlellstlgeKkkthtvkhysykgWieknd

PASPHSFVQFVRTVMTSQqraqasvaaatpPLLVHCSAGVGRTGTFIGTYATLC-SLHGIRRDK-HSIMIPLLVREMRRQRICMVQSLAQYEF
|  ... .. .. .  |.            .| ||||.|.||.  |  .       .. ..  .   .    |..|.| .| . ..   |  |
pelareilnilkvarnsk............slvvhcstGiGrsaafsvaElvyqkmirsldttstveldylsLleelrssrkraihtPmqLaf
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 142-209 1.2e-09 32.0 In-house 88-156 (349) alignment 
Range on Protein: 142-209
Range on HMM: 88-156/349.0
CKNDYINASYIKN-LLTGAPDFIASQGPTVPTIRSFWEMIAQYKLSVIVMVTNVLEGDLVKCDPYWPEI
  .||||| |.|   ..    .|| | |   |.  |...|   .. ... ...  | .| ||| || | 
klddyinanylkltrisvekkyiatqaPlPstvddfykvillngvklvlsLnddkelslekcdiywqel
subfamily_eak_pd Subfamily eak 129-368 1.8e-09 31.4 In-house 59-305 (332) alignment 
Range on Protein: 129-368
Range on HMM: 59-305/332.0
DILPFDHNRVKLKC----KNDYINASYIKNLLTGApDFIASQGPTVPTIRSFWEMIAQYKLSVIVMVTNVLEGDLVKCDPYWPEIG-QTLSFGSNSEFDG
.|.|.|.. |.|      .. ||||| ..    |   .| .  .    .  ||.|. . |   ||.. . .| .| | | |.|. . . |.||       
kivpydrylvrltssqlnrlGyinaslaefsevGr.kyiltGiasedkvfafwqmvleqkspaivqlledvelkleksdkyfpdktreelkfGildverk

SLsVQQldasdgVAWSRRTFALHYNDEPeRRITQFHYTDWPDQGVPASpHSFVQFVRTVMTSQQ-------RA-QAS---VAAATPPL---LVHCSAGVG
.  |..           | . |.  .|   |.  ...  | .  .|   . |. . ...             |   |       |||    .. .. |  
ef.vkr......niletrllelskGnet.hrvlhykvfGwtettlpky.edflalrkvmkevGvlllivmksallsstlkkyihtppsfapiiqsarGsa

RTGTFIGTYATLCSLHGIRRDKHSimIPLLVREMRRQRICMVQSLAQYEFLYKSILIAI
|.|.|.     .  . . ... .|  .  |.  .. .||  |    |. |.|. .|  .
raGvfvvidllirlidnkkknlys..vedlilkvkskrihsvlvalqhsfiyeivldyl
subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 130-268 5.1e-09 30.1 In-house 105-235 (244) alignment 
Range on Protein: 130-268
Range on HMM: 105-235/244.0
ILPFDHNRVKLK---CKNDYINASYIKNLlTGAPDFIASQGPTVPTIRSFWEMIAQYKLSVIVMVTNVLEGdlvkcDPYWPEIgQTLSFgsnSEFDGSLS
 |||| ||| |      | |||||..  |   . ..| .| |   |   || |. . .. |.|..  | |      | |||.  . | .    | | ...
glpfdfnrvplskgsmgntyinasfvgcl.grtaeyiltqhpladtsmdfwkmmlerhvnvlvvlgsveee.....deywpds.eplew...yeeditvt

VQQLDASDGVAWSRRTFALHYNdEPERRITQFHYTDWPDQGV
. . |    .  |        | |  . .| |  ..|| .| 
ltdrdefknikasnleiesdmn.eshqaltmfqisnwpsdgt
0038934 (Phosphotyrosine protein) phosphatases II 257-319 7.1e-08 27.8 In-house 81-137 (194) alignment 
Range on Protein: 257-319
Range on HMM: 81-137/194.0
QFHYTDWPDQGVPASPHSFVQFVRTVMTSQQRAQASvaaatpPLLVHCSAGVGRTGTFIGTYA
...   .||.|.. |     .|.. | .  .. .          .||| ||.|||||... | 
eylklpfpddgtvPsleillrfldlvdeflnedpgg......vvaVHCkaGlgRtGtlvaaYL
subfamily_Sponge-PTP-4_pd Subfamily Sponge-PTP-4 131-243 7.6e-07 23.5 In-house 3-102 (130) alignment 
Range on Protein: 131-243
Range on HMM: 3-102/130.0
LPFDHNRVKlkcKNDYINASYIKnLLTGAPDFIASQGPTVPTIRSFWEMIAQYKLSVIVMVTNVLEGdlvkcDPYWPEIgQTLSFgsnSEFDGSLSVQQL
|.|. .|..    |.|||||..  ||  . ... .| |   |   || |. .  . |.|..  | |      | |||.  . | .    | |  ... . 
lefevsrlq...gntyinasfvG.llgrtaeylltqhpladtsmdfwkmmleryvnvlvvlgsveee.....deywpds.ePlew...yeediivtltdr

DASDGVAWSRRTF
| .. .  |    
defknikasnlei
subfamily_Sponge-PTP-7_pd Subfamily Sponge-PTP-7 301-365 1.7e-06 22.4 In-house 2-62 (69) alignment 
Range on Protein: 301-365
Range on HMM: 2-62/69.0
LVHCSAGVGRTGTFIgtyATLCSLHGIRRDKHsIMIPLLVREMRRQRICMVQSLAQYEFLYKSIL
.||||.| |||||||   | .  .  |. .|  . |   |. ||. |  ||    .| |.. .. 
vvhcssgtgrtgtfi...aimvemariksekl.vdifnnvqymrkcrpmmvmneieyifihdalv
subfamily_Sponge-PTP7_pd Subfamily Sponge-PTP7 302-365 2e-06 22.0 In-house 2-61 (69) alignment 
Range on Protein: 302-365
Range on HMM: 2-61/69.0
VHCSAGVGRTGTFIgtyATLCSLHGIRRDKHsIMIPLLVREMRRQRICMVQSLAQYEFLYKSIL
||||.| |||||||   | .  .  |. .|  . |   |. ||. |  ||    .| |.. .. 
vhcssGtGrtGtfi...aimvemariksekl.vdifnnvqymrkcrpmmvmneneymfihdalv
subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 143-192 9.7e-06 19.3 In-house 69-117 (347) alignment 
Range on Protein: 143-192
Range on HMM: 69-117/347.0
KNDYINASYIKnLLTGAPDFIASQGPTVPTIRSFWEMIAQYKLSVIVMVT
 . |||||.|| .     ..| .| |   |.| || |.   |.. .| . 
vetyinashik.fdnaskeyiltqyplpdtvrdfwkmvsvtkvtqvvtif