Gene MbrePTP-sf1-8 in Monosiga brevicollis

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily MbrePTP-sf1
Protein sequence
ID Type Fasta BLAST phosphatome Note
MbreP056_AA protein Get Run
MbreP056_AA_1199-1491 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_PTPRD_pd Subfamily PTPRD 1211-1510 5.2e-94 310.9 In-house 19-302 (564) alignment 
Range on Protein: 1211-1510
Range on HMM: 19-302/564.0
LDAEGGLQTEFSRLQS-VGLRHKSCATQANRDKNRYRNITAYDHSRVVLQVNPEEGGCDYYNANYIAGARSPSDYIACQGPTNSSVDDFWRMVWQQKTQC
 . .  ...|. ....    . .... .||. |||| ||.|||||||||.  . . |.|| ||..| | |..  ||| |||......|||||||.|....
ansdlkfeeeykkieegqqftweaankpaNkaKNRyanivaYdhsRVvLskvegdegsDYINAsfidgyrkrkayIAtqgPlaetiedFWRmvweqnsst

IVMVTNLEEQGRMKCLKYWPDlapgvsaddlradELpKLQLGPYVVFFKERHEHKLWTQRVFELEHE-GEGRMTVTQFHMTAWPDHGVPSEPSDLLYFRQ
|||.|.|||.|. || ||||.             .  . . | ..| ..| .| .  . | |.|...  .  ..|.||| |.||||||| .. .|| ...
iVmltkleEkgkvkchkYWPe.............kg.tetygeltVtleeeeeladyeirtfklkkkkssesreVrqFhFtsWPdhgvpesatslLdlir

AIRAAFPNPTSPMLVHCSAGVGRSGTFIAIDHMLQLILDEaraasDVPDVRDVVHGMRDRRNFMVQTEEQYIFIYFALEMALTAMQAT-DKADLKMALDE
 .||. .. . |..|||||||||.||||.|| ||. | .|     .. |.. .|. .|  ||.|||||||||||. |.  ||....   .  .||..|..
kvralnepdagPivVhCSaGVGRTGtfividamlerikee.....ktvDiyqyvkalrkqRnamVqteeQYiFiheailealacgntevesenlkqhlqk

FHQ
 ..
Lae
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 1205-1491 4.7e-90 296.5 In-house 4-277 (281) alignment 
Range on Protein: 1205-1491
Range on HMM: 4-277/281.0
QHLQSKLDAE-GGLQTEFSRLQSVGLRHKSCATQ--ANRDKNRYRNITAYDHSRVVLQVNPEEGGCDYYNANYIAGARSPSDYIACQGPTNSSVDDFWRM
.||... . .  |...|.. |...|... . |..  .|. ||||.||.|||..||... | |.  .|| |||...| ... .|||.|||  .|...||.|
khlkqlsqndnaGfieeyeklaaigvdntataskadenvlknrYsnivaYDatrvkvtpneenkntDYinanfvpgykgekeyiatqgPvPaslvafWqm

VWQQKTQCIVMVTNLEEQGRMKCLKYWPDLAPgvsaddlradelpKLQLGPYVVFFKERHEHKLWTQRVFELEHEGEGRMTVTQFHMTAWPDHGVPSEPS
||.|| . |||||.  |.|..|| .|||| .              .|..| ..| .....|.. . .|.|.||.|.    .|.|.. |||||||||....
vweqkvsaivmvtreieagklkChrYWPddns.............elkygdvtvkstaeeekatyierkfkleresgetreveqlaytaWPdhGvPattk

DLLYFRQAI-RAAFPNPTSPMLVHCSAGVGRSGTFIAIDHMLQLILDEARAasdvPDVRDVVHGMRDRRNFMVQTEEQYIFIYFALEMALT
.|| ||... ..  ..   |...||||||||.||.||.| ... . .|..      ||..||. .| .||.||||  || |.| |.  || 
ellefrkevlkltekktkaplvihCsaGvGrtGtyialDrlvkaveaelee....ldvkavvaelrkernlmvqtvvqyefvykavldald
0051299 (Phosphotyrosine protein) phosphatases II 1210-1488 9.2e-88 289.7 In-house 18-284 (288) alignment 
Range on Protein: 1210-1488
Range on HMM: 18-284/288.0
KLDAEGGLQTEFSRLQSVGLRH--KSCATQANRDKNRYRNITAYDHSRVVLQVNPEEGGCDYYNANYIAGARSPSDYIACQGPTNSSVDDFWRMVWQQKT
...   ||. || .|.|.   .  .... ..|..||||..| .||||||.|.| ....|.||.||.|| | ...  .||.|||....|.|||||||.|..
langltglleefeellsllpdltlsaallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyidgynlkrkfIatqgPlpntvedFWrmvweqnv

QCIVMVTNLEEQGRMKCLKYWPDlapgvsA----DdlradelpklqlGPYVVFFKERHEHKLWTQRVFELEH-----EGEGRMTVTQFHMTAWPDHGVPS
..|||.|.|.| || || .|||.                        |...| ... .... .|.|..|...      ..   |||.||.|.|||||||.
rvIvmltklvelgrekcaqYwpl......ggslty............gditvtllseevlddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpd

EPSDLLYFRQAIRAAFPNPTSPMLVHCSAGVGRSGTFIAIDHMLQLILDEaraasDVPDVRDVVHGMRDRRNFMVQTEEQYIFIYFALEM
 |..|| | ...| |.... .|..|||||||||.|||||.|..|.... |      ..|| ..|. .| .|..||||.|||.|.| || .
spellldflrlvrkalasgggpvvVHCsaGvgRtgtfialdllleqleke.....ggvdvleavkrlreqRpgmvqtpeqyrfvyealle
0050432 (Phosphotyrosine protein) phosphatases II 1197-1490 3.3e-87 288.0 In-house 25-299 (308) alignment 
Range on Protein: 1197-1490
Range on HMM: 25-299/308.0
NEKVDAILQHLQSkLDAEGGLQTEFSRLQSVGLRHK--SCATQANRDKNRYRNITAYDHSRVVLqvnpeEGGCDYYNANYIAGA--RSPSDYIACQGPTN
.  |. .|..|.. ..  |.|..|| .|.||   ..  ... ..|.|||||..| .||||||.|     ..|.||.||.|. |   ..|  .||.|||..
klsvldllkllek.aldlglleeefeellsvkplleysvallpenkdkNrykdilpydhsRVkl.....degsdYInAsyvdgyssklprkfIatqgPlp

SSVDDFWRMVWQQKTQCIVMVTNLEEQGRMKCLKYWPDLAP-GV--SaddlradelpklqlGPYVVFFKERHEHKLWTQRVFELEH-EGEGRMTVTQFHM
..|.|||||||.|....|||.|.|.| || || .|||.    |.                 |...| ... .... .|.|..||.. ...   |||.||.
ntvedFwrmvweqnvrvIvmLtklvengrekcaqYwplelgggsley..............gkftvtllseevlddytvrtleltnlgdgesrtvthfhy

TAWPDHGVPSEPSDLLYFRQAIRAAFpnPTSPMLVHCSAGVGRSGTFIAIDHMLQLILDEaraasDVPDVRDVVHGMRDRRNFMVQTEEQYIFIYFALEM
|.|||||||..|..|| | ...|  .  | .|..|||||||||.|||||.|..|...  |       .|| ..|. .| .|..||||.|||.|.| || .
tnWpdhgvPpspeilldflelvrksl..pggpivVHCsaGvGRtGtfialdllleqleke.....ggvdvfeavkklReqRpgmvqtpeqylflyralle

AL
 |
yl
subfamily_PTPRB_pd Subfamily PTPRB 1204-1491 7.2e-87 286.1 In-house 13-286 (293) alignment 
Range on Protein: 1204-1491
Range on HMM: 13-286/293.0
LQHLQ-SKLDAEGGLQTEFSRLQSVGLRHKS--CATQANRDKNRYRNITAYDHSRVVLQVNPEEGGCDYYNANYIAGARSPSDYIACQGPTNSSVDDFWR
 .|..  | |.. ... |...|..||  ..     ...||.||||.|| .|||||| |.   .| | || ||||| | .|| ..||.|||  ..||||||
eehvkkmkadsdlrfseeyeelkavgkdqavkaaelavnraknrytnilpydhsrvkLaalkdesgsDYinanyipgynsprefiatqGPlpetvddfWr

MVWQQKTQCIVMVTNLEEQGRMKCLKYWPDLapgvsaddlradeLPKLQLGPYVVFFKERHEHKLWTQRVFELEHeGEGRMTVTQFHMTAWPDHGVPSEP
|||..|.. |||.|.| |.|..|| .|||.                  . |   | ... .| . |. | ...|. .. ...|.|.| |.|||||||...
mvwekkssiivmltqlvekgkvkCeeYWPad.............eepvlyGdikvtlvaeeeledwvirelkiek.ekeerkvrqyhftsWpdhgvPekt

SDLLYFRQAIRAAF--PNPTSPMLVHCSAGVGRSGTFIAIDHMLQLILDearaaSDVPDVRDVVHGMRDRRNFMVQTEEQYIFIYFALEMALT
. || | ...| |    . ..|..|||||||||.|||||.|..|| | .     .|. |.  .|. .| .||..||||.|||||. ..   |.
ktlldfvrtvreaiektaskrPivvhCsaGvGRtGtfialdrllqaiee.....edyvdifgivaelReeRnllvqtekqYifihqcvldllr
0046845 (Phosphotyrosine protein) phosphatases II 1216-1489 3.4e-85 281.2 In-house 1-273 (284) alignment 
Range on Protein: 1216-1489
Range on HMM: 1-273/284.0
GLQTEFSRLQSVGL----RHKSCATQANRDKNRYRNITAYDHSRVVLQVNPEE-GGCDYYNANYIAGA-----RSPSDYIACQGPTNSSVDDFWRMVWQQ
||. || .|.|.        . .. ..|..||||..| .||||||.|.. ... ...||.||.|. |      ...  .||.|||....|.|||||||.|
gleeefeellsltvklllslsvallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweq

KTQCIVMVTNLEEQGRMKCLKYWPDLaPGVSADdlradelpklqlGPYVVFFKERHEHKLWTQRVFELEHE--GEGRMTVTQFHMTAWPDHGVPSEPSDL
....|||.|.|.| || || .|||.   .|               |.. | ........ .|.|..||...  ..  .|||.||.|.|||||||..|.||
nvrvIVmltelvengrekcaqYwple.gevlty............gdftvtllseevkddytvrtleltnlgytgesrtvthfhytswpdhgvppspedl

LYFRQAIRAAFP--NPTSPMLVHCSAGVGRSGTFIAIDHMLQLILDEARAasDVPDVRDVVHGMRDRRNFMVQTEEQYIFIYFALEMA
| | ...| ...  .. .|..|||||||||.|||||.|..|...  | .    ..|| ..|. .|..|..||||.|||.|.| || ..
leflrlvrellenlpgggpivVHCsaGvgRtGtfialdllleqlekegll..lgvdvleavkrlreqRpgmvqtleqyrfvyealley
0036941 (Phosphotyrosine protein) phosphatases II 1214-1489 1e-82 273.1 In-house 12-276 (297) alignment 
Range on Protein: 1214-1489
Range on HMM: 12-276/297.0
EGGLQTEFSRLQSVGLRHK--SCATQANRDKNRYRNITAYDHSRVVLqvnpEEGGCDYYNANYIAGARSPSDYIACQGPTNSSVDDFWRMVWQQKTQCIV
  .|..||..|... |  .    . ..|..||||..| .|||.||.|    ...|.||.||.|. | . .  .||.|||....|.|||||||.|....||
lalllkefeellpllllgslsvallpenleknRykdilpydhtRVkl....ddegsdYinAsyvdgydlkrkfIatqgPlpntvedFWrmvweqnvtvIv

MVTNLEEQGRMKCLKYWPDLAPGVSADdlradelpklqlGPYVVFFKERHE--HKLWTQRVFELEH-EGEGRMTVTQFHMTAWPDHGVPSEPSDLLYFRQ
|.|.|.| || || .|||.  ...               |...|.... ..  .. .|.|..|... ...   |||.||.| |||||||. |..|| | .
mltelvelgrekcaqywpleegeslty............gdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfie

AIRAAFPN--PTSPMLVHCSAGVGRSGTFIAIDHMLQLILDEarAASDVPDVRDVVHGMRDRRNFMVQTEEQYIFIYFALEMA
..| . ..  . .|.||||||||||||||||.| |||.. |.       .|. ..|. .|..|...|||.|||.|.| || . 
lvrkvlkllpsggpvlVHCsaGvgRsgtfiaadlmlqqledk..lkeggvdileavkklReqRpgavqtleqyrflyeallel
0040438 (Phosphotyrosine protein) phosphatases II 1215-1490 1.7e-82 272.5 In-house 18-276 (317) alignment 
Range on Protein: 1215-1490
Range on HMM: 18-276/317.0
GGLQTEFSRLQSVGLRHKSC-ATQANRDKNRYRNITAYDHSRVVLQVNPEEGGCDYYNANYIAGARSPSDYIACQGPTNSSVDDFWRMVWQQKTQCIVMV
..|. || .|.|. | . |. . ..|.|||||..|  ||||||.|.. ..  ..||.||.|. | . .  .||.|||....|.|||||||.|....|||.
talleefedllslkldtysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyvdgpnlkrkfIatqgPlpntvedFwrmvweqgvtvivmL

TNLEEQGRMKCLKYWPDlapgvsA----DdlradelpklqlGPYVVFFKERHEHKLWTQRVFELEH-EGEGRMTVTQFHMTAWPDHGVPSEPSDLLYFRQ
|.||| || || .|||.                        |...| ... .|.. .| |..|.|. ...   |||.||.|.|||||||. |..|| | .
teleelgrekcaqYwpl......getlty............gdftvtllseeelagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfle

AIRAAFPNPTSPMLVHCSAGVGRSGTFIAIDHMLQLILDEAraasdVPDVRDVVHGMRDRRNFMVQTEEQYIFIYFALEMAL
|.|.|...| .|.||||||||||.|||||.. ||...  |       .|| ..|. .| .|. .|||.|||.|.| || . |
avrealedpggpvlVHCsaGvgRtGtfiaaylmleqlekeg.....gvdveeavkelreqRpgavqtpeqyrflydalleyl
0039614 (Phosphotyrosine protein) phosphatases II 1208-1486 4.9e-82 271.0 In-house 25-285 (297) alignment 
Range on Protein: 1208-1486
Range on HMM: 25-285/297.0
QSKLDAEGGLQTEFSRLQSVGLRHKSCATQANRDKNRYRNITAYDHSRVVLQVNPEE-GGCDYYNANYIAGARS-PSDYIACQGPTNSSVDDFWRMVWQQ
  |..  ..|..|| .|.|.    . .. ..|.|||||..| .||||||.|.....   ..||.||.|. | .  . ..||.|||....|.|||||||.|
lekansktllllefeellslkpdysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfIatqgPlpetvedFwrmvweq

KTQCIVMVTNLEEQGRmKCLKYWPDLAPgvsaddlradelpklQLGPYVVFFKERHEHKLWTQRVFELEHeGEGRMTVTQFHMTAWPDHGVPSEPSDLLY
....|||.|.|.| || || .|||.                  . |...| ... .... .|.|..|... ..   |||.|. | |||||||. ...|| 
gvtvivmLtklvelgr.kcaqywpeegg...............tygdftvtllkvehldgytvrtlevtn.ngesrtvthfqytgwpdhgvppslellle

FRQAIRAAFPN--PTSPMLVHCSAGVGRSGTFIAIDHMLQLILDEaraasDVPDVRDVVHGMRDRRNFMVQTEEQYIFIYFAL
| ...| |. .  .  |.||||||||||.|||||.. ||...  |       .|| ..|. .| .|. .|||..||.|.| ||
flelvrealaelpkggpvlVHCsaGvgRtGtfiaaylmleqleke.....ggvdvleavkelreqRpgavqtpsqyrflydal
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 1211-1509 2.1e-81 268.4 In-house 14-300 (318) alignment 
Range on Protein: 1211-1509
Range on HMM: 14-300/318.0
L--DAEGGLQTEFSRL---QSVGLRHKScATQANRDKNRYRNITAYDHSRVVLQVNPEEGGCDYYNANYIAGARSPSDYIACQGPTNSSVDDFWRMVWQQ
|  . |  |..|. ||   ..   ..||  ...|. |||| ||.||||.|| ||   .| | || ||||| | |.   |||.|.|    ..|||||||.|
lresGelllseeyerlsrseetvtslks.lepvnkaknryanilaydhtrvkLqmlegeegsDyinanyidGyrrkkayiaaqaPlpetieDfWrmvWeq

KTQCIVMVTNLEEQGRMKCLKYWPDLAPgVSADDLRADELPKLQLGPYVVffkerhehklwtqRVFELEHEGEG-RMTVTQFHMTAWPDHGVPSEPSDLL
... |||.|..||.|..|. .|||.  .  | ..|. .   ...|. ||.             | |......|    .| |.|.|.|||.|||.....||
nsavivmltqeeergkakvhryWPskgs.rsygklvvelkeevelsdyvl.............refkvtrteeeesrqvrqyhytsWpdegvpesgasll

YF-RQAIRAAFPNPTSPMLVHCSAGVGRSGTFIAIDHMLQLILDEARAasdvpDVRDVVHGMRDRRNFMVQTEEQYIFIYFALEMALTAMQAT-DKADLK
 . ||. .|  .. ..|..||||||||| |.|||.| .|. | .||       || ..|. .|..|| |||||.||.||| .|  ||.. ..  |  ||.
dlvrqvskaqqksgagpivvhCsaGvGrtGvfiavdillerikaealv.....Dvfqtvkqlreqrnlmvqtedqyefiydvllealasgdtevdasdlr

MALDEFH
  . |..
srirelr
0047943 (Phosphotyrosine protein) phosphatases II 1208-1486 2.6e-81 268.4 In-house 5-268 (273) alignment 
Range on Protein: 1208-1486
Range on HMM: 5-268/273.0
QSKLDAEGGLQTEFSRLQSVGLRH--KSCATQANRDKNRYRNITAYDHSRVVLqvnpEEGGCDYYNANYIAGARSPSDYIACQGPTNSSVDDFWRMVWQQ
  ||.  ..|. || .|.|.   .  . .. ..|.|||||..| .||||||.|    ..||.||.||.|. | ...  .||.|||....|.|||||||.|
lekllgltllleefelllslkplltysvallpenkdknrykdilpydhsrvkl....gdggsdyinAsyvdgynlkrkfiatqgPlpntvedfwrmvweq

KTQCIVMVTNLEEQGRMKCLKYWPDLapgvsaddlraDELPKLQLGPYVVFFKERHEHKLWTQRVFELEH-EGEGRMTVTQFHMTAWPDHGVPSEPSDLL
....|||.|.|.| || || .|||.             .  .|. |.. | ... .... .|.|..||.. . .   |||.||.| |||||||. ...||
nvrviVmLtelvelgrekcaqYwple...........ggelsltygkftvtllseetkddytvrtleltnlgtgesrtvthfhytgwpdhgvppslesll

YFRQAIRAAFPN--PTSPMLVHCSAGVGRSGTFIAIDHMLQLILDEaraasDVPDVRDVVHGMRDRRNFMVQTEEQYIFIYFAL
 | ...| |. .    .|..|||||||||.|||||.|..|...  |       .|| ..|. .|..|  ||||.|||.|.| ||
efielvrkalealpsngpvvVHCsaGvgRtgtfialdllldqleke.....ggvdvleavkllrsqRpgmvqtpeqyrflyeal
0045450 (Phosphotyrosine protein) phosphatases II 1205-1486 6.5e-80 264.4 In-house 17-300 (307) alignment 
Range on Protein: 1205-1486
Range on HMM: 17-300/307.0
QHLQSKLDAEGGLQTEFSRLQSVGL----RHKSCATQANRDKNRYRNITAYDHSRVVLQVNPEE-GGCDYYNANYI--------AGARSPSDYIACQGPT
. |. .||   ||. || .|.||       ... . ..|.|||||..| .|||.||.|.. ... ...||.||.|.         | ...  .||.|||.
lvllllldfltgllkefekllsvtvfllgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydlkrkfIatqgPl

NSSVDDFWRMVWQQKTQCIVMVTNLEEQGRMKCLKYWPDLaPGvsaddlradelpKLQLGPYVVFFKERHEHKLWTQRVFELEH--EGEGRMTVTQFHMT
...|.|||||.|.|....|||.|.|.| || || .||||   .            .|. |...| ... .... .| |..|...  . .   |||.||.|
petvedFwrmlweqgvtvivmltelvelgrekcaqywPde.ge............eltygnftvtllseehldgytvrtlevtdldgtgesrtvthfhyt

AWPDHGVPSEPSDLLYFRQAIRAAFPN--PTSPMLVHCSAGVGRSGTFIAIDHMLQLILDEARAASdvPDVRDVVHGMRDRRNFMVQTEEQYIFIYFAL
.|||||||. ...|| | ...|.|. .  . .|.||||||||||.|||||.. ||... .|       .|....|. .|..|  .||..|||.|.| ||
gwpdhgvppsfeelldfieevrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlld..vdlleavkllreqRpgavqnpeqyrflyeal
0043336 (Phosphotyrosine protein) phosphatases II 1209-1486 1.3e-79 262.9 In-house 14-273 (278) alignment 
Range on Protein: 1209-1486
Range on HMM: 14-273/278.0
SKLDAEGGLQTEFSRLQSVGLRHKSCAT-QANRDKNRYRNITAYDHSRVVLQVNPEEGGCDYYNANYIAGARSPSDYIACQGPTNSSVDDFWRMVWQQKT
 .|.   .|. || .|.|. | ..|.|  ..|.|||||..| .||||||.|.. ... ..||.||.|. | . | ..||.|||....|.|||||||....
lllnlktllllefeellsfkldtysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyvdgynvprkfiatqgPlpetvedFwrmvwelgv

QCIVMVTNLEEQGRMKCLKYWPdlapgvsaddlradeLPKLQLGPYVVFFKERHEHKLWTQRVFELEH-EGEGRMTVTQFHMTAWPDHGVPSEPSDLLYF
..|||.|.|.| || || .|||                  |. |...| ... .... .|.|..|...       |||..| ..|||||||. .|.|| |
ttivmLtelvelgrvkcaqYwp...............ggsltygdftvtllkeehlddytvrtlevtnlgdgesrtvthyhylgwpdhgvpeslsllldf

RQAIRAAFPNPTSPMLVHCSAGVGRSGTFIAIDHMLQLILDEAraasdVPDVRDVVHGMRDRRNFMVQTEEQYIFIYFAL
 .|.| |.... .|.||||||||||.|||||.. .|... .|       .|. ..|. .| .|  .|||..||.|.| ||
lkavrealedsngpvlVHCsaGvgRTGtfialyllleqlekeg.....gvdleeavkelreqRpgavqtpsqyrflyeal
DSPc_SM00195 1217-1486 3e-79 261.4 In-house 2-258 (263) alignment 
Range on Protein: 1217-1486
Range on HMM: 2-258/263.0
LQTEFSRLQSVG--LRHKSCATQANRDKNRYRNITAYDHSRVVLQVNPEEGGCDYYNANYIAGARSPSDYIACQGPTNSSVDDFWRMVWQQKTQCIVMVT
|..||..|..     . .. . ..|..||||.||  |||.|| |. .... | ||.||||| ||.....|||.|||..| |.|||||||..|...|||.|
lkeefekleestspketteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlt

NLEEQGRMKCLKYWPDLApgvsaddlradeLPKLQLGPYVVFFKERHEHK-LWTQRVFELEHEG-EGRMTVTQFHMTAWPDHGVPSEPSDLLYFRQAIRA
. ||.|. || .|||. .              | . | . | ..| ...|  ...|..||..|| |   .|||.....|||||||......| . .|.. 
eeeengkekcdrywpees............ggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkk

AFPNPTSPMLVHCSAGVGRSGTFIAIDHMLQLILDEARaasdvPDVRDVVHGMRDRRNFMVQTEEQYIFIYFAL
   . ..|..|||||||||.|||..|| .|. . .| .     .|. ..|  .|. |  ||||.|||.||| |.
skstssgpivVhCsaGvgRtgtfvtidiilskleeekk.....vdifeivkelRkqRpgmvqtleqYlfiyeai
PTPc_SM00194 1217-1486 3e-79 261.4 In-house 2-258 (263) alignment 
Range on Protein: 1217-1486
Range on HMM: 2-258/263.0
LQTEFSRLQSVG--LRHKSCATQANRDKNRYRNITAYDHSRVVLQVNPEEGGCDYYNANYIAGARSPSDYIACQGPTNSSVDDFWRMVWQQKTQCIVMVT
|..||..|..     . .. . ..|..||||.||  |||.|| |. .... | ||.||||| ||.....|||.|||..| |.|||||||..|...|||.|
lkeefekleestspketteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlt

NLEEQGRMKCLKYWPDLApgvsaddlradeLPKLQLGPYVVFFKERHEHK-LWTQRVFELEHEG-EGRMTVTQFHMTAWPDHGVPSEPSDLLYFRQAIRA
. ||.|. || .|||. .              | . | . | ..| ...|  ...|..||..|| |   .|||.....|||||||......| . .|.. 
eeeengkekcdrywpees............ggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkk

AFPNPTSPMLVHCSAGVGRSGTFIAIDHMLQLILDEARaasdvPDVRDVVHGMRDRRNFMVQTEEQYIFIYFAL
   . ..|..|||||||||.|||..|| .|. . .| .     .|. ..|  .|. |  ||||.|||.||| |.
skstssgpivVhCsaGvgRtgtfvtidiilskleeekk.....vdifeivkelRkqRpgmvqtleqYlfiyeai
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 1208-1487 3.2e-76 251.1 In-house 14-276 (288) alignment 
Range on Protein: 1208-1487
Range on HMM: 14-276/288.0
QSKLDAEGGLQTEFSRLQSVGLRHKSCATQ--ANRDKNRYRNITAYDHSRVVLQVNPEEGGCDYYNANYIAGARSPSDYIACQGPTNSSVDDFWRMVWQQ
. . ... |.. |.  | ...  ....|..   | .||||||| .||. || |.  .|| | || ||.||.| ..   ||| |||  ..|.|||..|...
kksarnrtgfseeynsLaalektksvtagrlavnakknRyrnilpyDekrvklkkleeeagaDYinasyidgekkkkkyiatqgPladtvndfWelvyen

KTQCIVMVTNLEEQGRMKCLKYWPDlapgvsaddlraDELPKlQLGPYVVFFKERHEHKLWTQRVFELEhEGEGRMTVTQFHMTAWPDHGVPSEPSDLLY
||. |||.|.| |.|. || .||||            .. || . |   |  .| .| . ...| ..||   ......||.. .||||||||    .|| 
ktstivmltelveggktkCeeYWPd............adkpk.nyGsvtvtlveskeledfvlrkllle.kkkteleitqyqylaWpdhgvPeskaplle

FRQAIRAAFPNPTSPMLVHCSAGVGRSGTFIAIDHMLQLILDearaaSDVPDVRDVVHGMRDRRNFMVQTEEQYIFIYFALE
... .  | .. | |..|||||||||.|||||.| ... .       .|. || ..|. .| .|...|||..||.||| .| 
llrqvkvanqadtgpiivhCsaGvGrtgtFialdalidavee.....edyiDvagtvaklRkqRallvqtlkqYefiyevll
0040439 (Phosphotyrosine protein) phosphatases II 1234-1488 3.9e-74 244.7 In-house 6-244 (249) alignment 
Range on Protein: 1234-1488
Range on HMM: 6-244/249.0
CATQANRDKNRYRNITAYDHSRVVLQVNPEEGGCDYYNANYIAGARSPSDYIACQGPTNSSVDDFWRMVWQQKTQCIVMVTNLEEQGRMKCLKYWPDlap
.  ..|.|||||..| .||||||.|.. |.  ..||.||.|| | ... ..||.|||....|.|||||.|... ..|||.|.|.| || || .|||.   
allpenkdknrypdilpydhsrvklsilpglflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywpl...

gvsA----DdlradelpklqlGPYVVFFKERHEHKLWTQRVFELEH-EGEGRMTVTQFHMTAWPDHGVPSEPSDLLYFRQAIRAAFPN--PTSPMLVHCS
                     | ..| ... .... .|.|..||.. .     ||.....| |||||||. ..||| | .|.| |. .  . .|.|||||
...ggsley............gdftvtllsvevkddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCs

AGVGRSGTFIAIDHMLQLILDEARaasdvPDVRDVVHGMRDRRNFMVQTEEQYIFIYFALEM
|||||.|||||.. ||...  | .      |. ..|. .|..|. .||..|||.|.| || .
aGvgRtGtfiaaylmleqlekelg.....vdleeavkllrsqRpgavqnpeqyrflyealle
Y_phosphatase Protein-tyrosine phosphatase 1239-1486 4.3e-74 244.2 Pfam-A 1-233 (235) alignment 
Range on Protein: 1239-1486
Range on HMM: 1-233/235.0
NRDKNRYRNITAYDHSRVVLqvNPEEGGCDYYNANYIAGARSPSDYIACQGPTNSSVDDFWRMVWQQKTQCIVMVTNLEEQGRMKCLKYWPdlapgvsad
|..||||..|..||..|| |  . .|| .||.||||. | .... .||.|||..|...||||||||.|...|||.|.|||.|| || .|||         
nkkknRykdilpydktrvkl..kgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwp.........

dlRADELpKLQLGPYVVFFK-ERH-EHKLWTQRVFELEHEGEGR--MTVTQFHMTAWPDHGVPSEPSDLLYFRQAIRAAFPNPTSPMLVHCSAGVGRSGT
  ...|  .|. | . |  | . . ..| .| |..||....| .   .|.|.|.|.|||||||..|..|| . ....    . ..|..|||||||||.||
..eeeee.sltygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgt

FIAIDHMLQLILDEARaasdvPDVRDVVHGMRDRRNFMVQTEEQYIFIYFAL
|.|.| .|. . .|       .|| ..|  .| .|. |||..|||||.| |.
fvaldilleqleaeee.....vdvlqivkelRkqRpgmvqsleqYiflykai
Y_phosphatase Protein-tyrosine phosphatase 1239-1486 4.3e-74 244.2 In-house 1-233 (235) alignment 
Range on Protein: 1239-1486
Range on HMM: 1-233/235.0
NRDKNRYRNITAYDHSRVVLqvNPEEGGCDYYNANYIAGARSPSDYIACQGPTNSSVDDFWRMVWQQKTQCIVMVTNLEEQGRMKCLKYWPdlapgvsad
|..||||..|..||..|| |  . .|| .||.||||. | .... .||.|||..|...||||||||.|...|||.|.|||.|| || .|||         
nkkknRykdilpydktrvkl..kgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwp.........

dlRADELpKLQLGPYVVFFK-ERH-EHKLWTQRVFELEHEGEGR--MTVTQFHMTAWPDHGVPSEPSDLLYFRQAIRAAFPNPTSPMLVHCSAGVGRSGT
  ...|  .|. | . |  | . . ..| .| |..||....| .   .|.|.|.|.|||||||..|..|| . ....    . ..|..|||||||||.||
..eeeee.sltygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgt

FIAIDHMLQLILDEARaasdvPDVRDVVHGMRDRRNFMVQTEEQYIFIYFAL
|.|.| .|. . .|       .|| ..|  .| .|. |||..|||||.| |.
fvaldilleqleaeee.....vdvlqivkelRkqRpgmvqsleqYiflykai
0042113 (Phosphotyrosine protein) phosphatases II 1234-1486 4.1e-73 241.1 In-house 4-239 (245) alignment 
Range on Protein: 1234-1486
Range on HMM: 4-239/245.0
CATQANRDKNRYRNITAYDHSRVVLQVNPEEGGCDYYNANYIAGARSPSDYIACQGPTNSSVDDFWRMVWQQKTQCIVMVTNLEEQGRMKCLKYWPDlaP
.. ..|.|||||..| .|||.||.|.. ... ..||.||.|. | | .  .||.|||....|.|||||.|... ..|||.|..|| || || .|||.   
allpenkdknrysdilpydhtrvklspdggdldsdyinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywpl..g

GVSADdlradelpklqlGPYVVFFKERHEHKLWTQRVFELEH-EGEGRMTVTQFHMTAWPDHGVPSEPSDLLYFRQAIRAAFP-NPTSPMLVHCSAGVGR
..               | ..| ... . .. .|.|..|...       .|...| . |||||||. ...|| | ...| |   ..  |.||||||||||
eslty............gdftvtllseehlddytvrtlevtnlgddesrevihyhylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgR

SGTFIAIDHMLQLILDEAraasdVPDVRDVVHGMRDRRNFMVQTEEQYIFIYFAL
.|||||.. ||...  |        .. ..|. .|..|  .|||..||.|.| ||
tGtfiaaylmleqlekel.....gvsleeavkelrsqRpgavqtpsqyrflyeal
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 1214-1494 2.9e-72 238.4 In-house 26-294 (298) alignment 
Range on Protein: 1214-1494
Range on HMM: 26-294/298.0
EGGLQTEFSRLQSVGL-----RHKSCATQANRDKNRYRNITAYDHSRVVLQVNPEEGGCDYYNANYIAGARSPSDYIACQGPTNSSVDDFWRMVWQQKTQ
  |...|| ||.||        ..   ...|..|||| .| |.|.|||||. . ..  .|| || .. ...  . .||.|.| ...| ||||||.... .
ltgyalefqrlnsvsseieeeekevarkpenkkkNRyadiialdssRvvLekedadeesdYiNAsflhaykgrnafiatqaPltetvedFWrmvteedig

CIVMVTNLEEQGRMKCLKYWPDLAPgVSADDLRAdelpklqlgpyvvFFKERHEHKLWTQRVFELEHEG-EGRMTVTQFHMTAWPDHGVPSEPSDLLYFR
.|||.|||||....|. |||||       ....                ....|.   ..| ......  |.. .| |.|.| |||.|||.. . .| ..
tiVmltnleeldktkyhkywPdegk.etygeitv.............sllskeefadlivrklkvskkkeekerevrqlhftsWpdkgvpenatsvldll

QAIRAaFPNPTS--PMLVHCSAGVGRSGTFIAIDHMLqlilDEARAaSDVPDVRDVVHGMRDRRNFMVQTEEQYIFIYFALEMALTAMQ
. .||  .. .   |..|.||||||||||||||| .|    . ... . | ||..||. .| .|  .|||||||.||| |   ||.. .
rkvra.sqqqagnkpvivqCsaGvgRsGtfiaidsvl....ervkk.eqvvDvfqvvkvlRkkrpgavqteeqYvfiyeavlealdsfn
0045098 (Phosphotyrosine protein) phosphatases II 1220-1488 3.2e-72 238.6 In-house 14-270 (278) alignment 
Range on Protein: 1220-1488
Range on HMM: 14-270/278.0
EFSRLQSVGLRHKSCATQANRDKNRYRNITAYDHSRVVlqvnpeeggcDYYNANYIAGArsPSDYIACQGPTNSSVDDFWRMVWQQKTQCIVMVTNLEEQ
|| .|..   .        |.|||||..| .||||||.          || ||.|| |   |  .||.|||..| |.|||||.|......|||.|.|.| 
efllllgipseitpalylgnldknRykdilpydhsrVk..........dYINAsyidgy..pkkfIatqgPlpstvadfwrmlwelgitvivmltelvel

GRMKCLKYWPDlaPGVS-AddlradelpklqlGPYVVFFKERHEHKLWTQRVFELEH-----EGEGRMTVTQFHMTAWPDHGVPSEP--SDLLYFRQAIR
|| || .|||.   |.                |...| ... .... .| |......     |.   ..||..|.. ||||||||.|  . .| . . ||
grekcaqywpe..ggslty.............gdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefir

AAFPN-------------PTSPMLVHCSAGVGRSGTFIAIDHMLQLIldearaaSDVPDVRDVVHGMRDRRNF-MVQTEEQYIFIYFALEM
.|  .             .  |.||||||||||.||..|.. ||.|.        .. |. ..|. .| .|.. .||..|||.|.| .| .
ealkllaslllsslllldsggpvlVHCsaGvgRtGtlvaaylmlell.......eggvdlleavkelrsqRpglavqnleqyrflyeflle
subfamily_PTPRG_pd Subfamily PTPRG 1206-1495 8.5e-72 237.1 In-house 9-292 (563) alignment 
Range on Protein: 1206-1495
Range on HMM: 9-292/563.0
HLQS-KLDAEGGLQTEFSRLQS----VGLRHKSCATQANRDKNRYRNITAYDHSRVVLQVNPEEGG-CDYYNANYIAGARSPSDYIACQGPTNSSVDDFW
|. | . |.. |.. ||  |||      |  ..   . |. |||| ||.|||.||| |.  |.. .  || ||||| | .   ..|| ||| .. .||||
hvaslhadgdigfseefealqsetiskdldaehsqkpenkrKnRylnivaydrsRvklsplpgkkkklDYinAnyidGyqkskafiatqgplkdtfddFW

RMVWQQKTQCIVMVTNLEEQGRMKCLKYWPDlAPGVSADDLRADELPKLQLGPYVVFfkerhehKLWTQR-VFELEHEGEGRMTVTQFHMTAWPDHGVPS
||.|.|... |||.|||.|.|| ||  |||     .  . |.     . .|  | |        .|  .    . ... .   .|.|.|.| |||||||.
rmiWeqnvaiivmitnlvergrrkcdvYWPk.desetygalqvtlieeevlalytvr.......tlviknlklkkkkqcdteklvrqyhytkWPdhgvPe

EPSDLLYFRQAIRAAFPNPTSPMLVHCSAGVGRSGTFIAIDHMLQLILDEaraasDVPDVRDVVHGMRDRRNFMVQTEEQYIFIYFALEMALTAMQA
 .   | | .   || .. . |..|||||||||.||.|..| .|. | .|     .. .| .... .| .|||.|||||||||.. ||  |... . 
hslpvLifvkkssaankaeaGPivvHcsaGvgrtGtyivldtllkqiqqe.....navnvfgflkhiraqRnflvqteEqYiflhdalleaiasket
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 1204-1511 8.9e-71 233.5 In-house 14-305 (319) alignment 
Range on Protein: 1204-1511
Range on HMM: 14-305/319.0
LQHLQSklDAEGGLQTEFSRLQS-VGLRHKSCATQANRDKNRYRNITAYDHSRVVLQVNPEEGGCDYYNANYIAGARSPSDYIACQGPTNSSVDDFWRMV
|..|.|   .| .|. ||  |.  |    .|. .. |..||||.|| |||..||||.  ..  | || ||..| | .  . .|| |.| .  ..||||||
lkalas..tgetllekefkllkeavndtfdsaskeenkkknryqnilaydrtrvvlseldgvegsdyinasfidgyqerekfiatqaPlentiedfWrmv

WQQKTQCIVMVTNLEEQGRMKCLKYWPDLAPgvsaddlradelpkLQLGPYVVFFKERHEHKLWTQRVFELEHEGeGRM---TVTQFHMTAWPDHGVPSE
|.... ..||.|.| |....|. ||||.  .               . | ..|  .|..| . .  | ..|..   . .   .|..|. |.||||.|| .
Weeessivvmltklveklkvklkkywpeenf..............eeyGrlivtleeeeeledyiirklklnkks.sevetRevkhfqyteWpdhdvPek

PSDLLYFRQAIRAAFPN-PTSPMLVHCSAGVGRSGTFIAIDHMLQLILDEAraasdVPDVRDVVHGMRDRRNFMVQTEEQYIFIYFALEMALTAMQ-ATD
   || . . || .  .    |. ||||||||| ||||..| ||. .  |.     | ||  .|  .|  ||.|||..|||.||| ||  |..| .   .
atslldllkrirksrektqsgPivvhCsaGvGRtGtfivldamlervkeeg.....vlDvfstvsrlRtqRnimvqrpeqYkfiyealleaveagdteie

KADLKMALDEFHQH
  ||.. | .. ..
vqdlrdrlkqlaek
subfamily_PTPN6_pd Subfamily PTPN6 1206-1492 5.4e-70 230.8 In-house 18-299 (306) alignment 
Range on Protein: 1206-1492
Range on HMM: 18-299/306.0
HlQSKLDAEGGLQTEFSRLQSVGLR----HKSCATQANRDKNRYRNITAYDHSRVVLQvNPEEGGCDYYNANYIAGARS--PSDYIACQGPTNSSVDDFW
. ...  .  |.. || .||    .    .|  | . |. ||||.||  .||.||.|. .|.  | || ||||| ..       ||| ||  .. | |||
k.eeeslekagfeeefeelqqeeakkllsrkegakpenkeknryknilPfDhtrvilk.epsvpgsdyinanyikkevkgsdksyiatqgclettvsdFW

RMVWQQKTQCIVMVTNLEEQGRMKCLKYWPDLAPGVSADDLRADELPKLqlgpyvvffkerhEHKLWTQRVFELEH--EGEGRMTVTQFHMTAWPDHGVP
|||||.... |||.|.  |.|. || .||||     .  ...  .. .              ... .. | . ...  ...   .| |.| ..|||||||
rmvwqensrvivmttkevErgkekCarYWPdeeekeeyGkisvtnvsek.............sladYilRelsvskkkkkkeerevfqyhfksWPdhgvp

SEPSDLLYFRQAIRAAFPNPT----SPMLVHCSAGVGRSGTFIAIDHMLQLILDEARAAsDVpDVRDVVHGMRDRRNFMVQTEEQYIFIYFALEMALTA
..|. .| | . ...   . .     |..||||||.|| |||| || .|.||  .   | |. |....|. .|. |. .||||.|| |.| |... . .
kdpgavLdfledvnrkqeeleeaeagpivvhCsaGiGRtGtfiviDillkliekkglda.di.diqklvksvreqrsglvqteqqykfvykaikkyiet
0037934 (Phosphotyrosine protein) phosphatases II 1235-1486 6.2e-70 230.8 In-house 6-238 (243) alignment 
Range on Protein: 1235-1486
Range on HMM: 6-238/243.0
ATQANRDKNRYRNITAYDHSRVVLqvnpeEGgCDYYNANYIAGArsPsDYIACQGPTNSSVDD----FWRMVWQQKTQCIVMVTNLEEQGRMKCLKYWPd
  ..|..||||..| .||||||.|     || .||.|||.| .   |  .||.|||....|.|    ||||.|......|||.|.|.| || || .||| 
llpenlsknrysdilpydhsrvkl.....eg.sdyinanliyvt..p.rliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywp.

lapgvsaddlraDELpklQLGPYVVFFKERHEHKLWTQRVFELEH--EGEGRMTVTQFHMTAWPDHGVPSEPSDLLYFRQAIRAA--------FPNPTSP
            .|    . |...| ... .... .|.|...||.  ...   .|...| ..|||||||..|.||| | ...|.           .. .|
............gev...tygdftvtllseehlddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggp

MLVHCSAGVGRSGTFIAIDHMLQLIldearaasDvPDVRDVVHGMRDRRNF-MVQTEEQYIFIYFAL
.||||||||||.||.||.. ||.|.        .  |. ..|. .|..|.. .|||..||.|.| ||
vlVHCsaGvgRtGtliaaylmllll........g.vdleeavkllreqRpgkavqtpsqyrflyeal
subfamily_PTPRA_pd Subfamily PTPRA 1217-1509 4.2e-68 224.7 In-house 34-315 (330) alignment 
Range on Protein: 1217-1509
Range on HMM: 34-315/330.0
LQTEFSRLQS--VGLRHKSCATQANRDKNRYRNITAYDHSRVVLQVNPEEGGCDYYNANYIAGARSPSDYIACQGPTNSSVDDFWRMVWQQKTQCIVMVT
.. ||  | .  .    . .. . |..|||. ||  ||.|||.|.|   .   || || .| | .    .||.||| . .|.|||||.|.||.. |||.|
freefnalPagpiqatlelaskeenkeknrvvnilPydfsrvilsvkeGveesdyinasfidGykekdkfiaaqGPkeetvedfwrmiweqksativmlt

NLEEQGRMKCLKYWPDLApGVSADDLRADELPKLQLGPYVVffkerheHKLWTQRVFELEHEGEGRMtVTQFHMTAWPDHGVPSEPSDLLYFRQAIRAAF
.|.|. . || .||||    |.  ..|     .  |  | |        |.  |.. .  .| . |. |.|||.|.||| |||.||  .| . .....  
elkerkeekcaqywPdeG.lvtyGnirvevedetvlvdytv.......rkflvqqlpdatrekksrl.vrqfhftswPdvGvPfepiGmlkllkkvkkln

PNPTSPMLVHCSAGVGRSGTFIAIDHMLQLILDEaraasDVPDVRDVVHGMRDRRNFMVQTEEQYIFIYFALEM-ALTAMQATDKADLKMALDEFH
.. ..|. |||||||||.||||..| .|. .  |      . || ..|. .| .|  ||||.||| ||| .|    | .    | . |.  |....
qqsagpivvhcsaGvGrtGtfivldavlervkae.....rkvdvfefvkrlrlqrpqmvqtdeqyefiykvlleyylygdteldvsslekhlqkly
subfamily_PTPN12_pd Subfamily PTPN12 1230-1488 6.7e-68 223.7 In-house 31-275 (290) alignment 
Range on Protein: 1230-1488
Range on HMM: 31-275/290.0
RHKSCATQANRDKNRYRNITAYDHSRVVLQVNPEEGGCDYYNANYIAGARSPSDYIACQGPTNSSVDDFWRMVWQQKTQCIVMVTNLEEQGRMKCLKYWP
. ..  .. |. ||||..|  ||.|||.|. . || | || |||.| |. ..  ||| |||    .||||||.|..... .||. .. | |..|| .|||
steagekeenvkknrykDilPydksrvelskieeeegsdYinanfikgvegkleyiaaqgPLpktlddfWrmiweknveivvmaCrevelgkkkCerYWp

DLApgvsADdlradelpKLQLGPYVV-FFKERHEHKLWTQRVFELEHEGEGRmTVTQFHMTAWPDHGVPSEPSDLLYFRQAIRAAFPNPTSPMLVHCSAG
.       .        .|. |.. |   .|.. .. .. | ...|...| | .|.||| |||||||||| ...|| . ...|    .  .|..||||||
eeg....ee........elefgefevtleeekavdddflirtLkveaqkesr.kvyqfhYtaWPDhgvPssaksllelielvrelqesedaPlvvhCsaG

VGRSGTFIAIDHMLQLILDEAraASDVPDVRDVVHGMRDRRNFMVQTEEQYIFIYFALEM
||| || ||||.. .|. .|    ..  || |.|  .| .|. .|||.||| ..| |.. 
vGrtGtiiaidyvrellkaek..ipeeldvfdlvlelrkqraalvqtkeqyelvykavae
subfamily_PTPRK_pd Subfamily PTPRK 1199-1502 1.1e-66 219.9 In-house 5-290 (314) alignment 
Range on Protein: 1199-1502
Range on HMM: 5-290/314.0
KVDAILQHLQSKLDAE-GGLQTEFSRLQSVglrHKSCATQANRDKNRYRNITAYDHSRVVLQVNPEEGGCDYYNANYIAGARSPSDYIACQGPTNSSVDD
.|. .||...    ||  |.. |.  |        ..  . ||.|||. .| |||.|||.|..  ..   || ||..| . . |. .|. ||| .. | |
rvadllqsiallkraegygfkeeyeslfeg...wdaakkdenreknrsgdilaydrsrvflitidgdpssdyinaalidsykrpaafivtqgPlqetvkd

FWRMVWQQKTQCIVMVTNLEEQGRMKCLKYWPDLAPGvsADDLRadelpklqlgpyvVFFKERHEHKLWTQRVFELEH---EGEGRMTVTQFHMTAWPDH
|||.|..... .|||.|.| |.||.|||||||. .     .|..             | . | . ..   .|.| .|.     |.. .| ||. ..||||
fWrlvydencasivmltelvevgrvkClkyWPedtev..ygdik.............velvetellaelvvrifrveklargqeeirevrqfqflgWpdh

GVPSEPSDLLYFRQAIRAAFPNPTSPMLVHCSAGVGRSGTFIAIDHMLQLILDEaraasDVPDVRDVVHGMRDRRNFMVQTEEQYIFIYF-ALEMALTAM
.|| .   || . . . .  ..   ...|||||| ||.||||||| .|..|  |     .| ||  .|. .|.|.  ||.|||||.|||  .|| .|   
dvPvsatgllklvrrvkksqeeeaGrivvhCsaGaGrtGtfiaidivldmiere.....gvvdvfnavktlrsrkvnmveteeqykfiydvileaclcge

QATDKADLK
 |   ...|
taipvsefk
subfamily_Ptp69D_pd Subfamily Ptp69D 1209-1490 2.7e-66 218.8 In-house 16-286 (307) alignment 
Range on Protein: 1209-1490
Range on HMM: 16-286/307.0
SKLDAEGGLQTEFSRLQ--SVGLRHKSCATQANRDKNRYRNITAYDHSRVVLQVNPEEGGCDYYNANYIAGARSPSDYIACQGPTNSSVDDFWRMVWQQK
.| |.. ||. |. .|.   . .  |  . . |  |||| .|.|.|. ||.|.. . .   || ||..| | .   ..|| |.| .. ..|||||...|.
rkrdtdfglakeyekLeareidkstkvsekkenalknRyedikafDktRvkLkkingkedsdYinasfikgykekkkfiaaqdPveatigDfWRmiaeqe

TQCIVMVTNLEEQGRMKCLKYWP-DlapgvsaddlradelPKLQLGPYVVFFKERHEHKLWTQRVFELEHEG------EGRMTVTQFHMTAWPDHGVPSE
 . |||..||.|. | || |||| .                . | |  .| . . ..|. ...| ... . .      | .  |.|.| |.|.|  ||  
vtlivmlsnlteknrkkcakYWpie...............devqygdilvklvseekhsdyiiReldvskkkeesgevedsrkvvqyhytgWkDskvPev

PSDLLYFRQAIRAAFPNPTSPMLVHCSAGVGRSGTFIAIDHMLQLILDEARAasdvpDVRDVVHGMRDRRNFMVQTEEQYIFIYFALEMAL
.  || . . .|    .  ||..|||||||||||.|.|.| .|| .  | ..     |. ..|...| .||..||  |||.|.| ||    
argllklieqvrelyklnrsPivvhCsaGvgrsgifvaldsllqqlkaedkv.....difetvkdLrsqRnllvqsleqYvflyralldys
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 1204-1494 1.1e-63 210.2 In-house 10-287 (305) alignment 
Range on Protein: 1204-1494
Range on HMM: 10-287/305.0
LQHL-QSKLDAEGGLQTEFSRLQSVGLRHKSCATQANRDKNRYRNITAYDHSRVVLQVNPEEGGCDYYNANYIAGARSPSDYIACQGPTNSSVDDFWRMV
 ... ... . . ||....  |.. .   .   ..||. |||...|| .|..|. |. .....  || ||.|. | ..   ||. ||| .. |.||||..
aayikearvysdkgleaqykslyeeeesidvgkkeankaknrlkeitlldddriiltekeslddsdyinasyvdgykrkkkyivaqgPlkntvadfWrli

WQQKTQCIVMVTNLEEQGRMKCLKYWPDlapgvsaddlR--AdelpKLQLGPYVVFFKERHEHKLWTQRVFELEH--EGEGRMTVTQFHMTAWPDHGVPS
.. |.. |||.|.| |.|. || .|||.          .       | ..|...|  |.... . ...| ...    | .   ||.|...| ||||||| 
veekvstivmltklveggkdkCrqYWpe..........skte....kkefgefsvelksektasdyieRklkisiededkesrtvlqyqltdWPdhGvpq

EPSDLLYFRQAIRAAFPNPTS-PMLVHCSAGVGRSGTFIAIDHMLQLILDEaraasDVPDVRDVVHGMRDRRNFMVQTEEQYIFIYFALEMALTAMQ
... || . . .. .  .    |.||||||||||.|.|||.| .|. .  |     .| || .|.. .| .|  |||| .|| |.. ||.  .|. .
fatsllslikrvqkdqkkdkgvpllVhCsagvgRtGvfiavdialerlkkE.....evvdvfevlkqlRskrmkmvqtldqYvflhdaldelitcgd
subfamily_PTPN13_pd Subfamily PTPN13 1206-1492 1.7e-63 209.5 In-house 3-271 (273) alignment 
Range on Protein: 1206-1492
Range on HMM: 3-271/273.0
HLQSKLDAeGGLQTEFSRLQSVGLRHKSC--ATQANRDKNRYRNITAYDHSRVVLQvnpEEGGcdYYNANYIAG--ARSPSDYIACQGPTNSSVDDFWRM
 ||.|||  .  . ||  |. .    ..    ...|.|||||||.  ||..|| |.   .|||  | ||..|         .|||||||   .|.|||.|
alqkkldq.qqPaeefkelrelkpldtcevgkkkenkdknryrnvlPydetrvklg...degg..yinaslikvpvgkdeyeyiacqGPlPetvkdfwqm

VWQQKTQCIVMVTNLEEQGRMKCLKYWPDLApgvsADDLRADELPKLQLgpyvvffKERHEHKLWTQRVFELEHEGEG-RMTVTQFHMTAWPDHGVPSEP
||.||.. |.|||.  |.|..|| .|||. .     . | . .  ...|        .  ... ...| .....   |    |.......||||||||..
vweqkaeviamvtlekekgkvkchrywPesk....nkklkvsnrlevel.......lkvqkldgfvvralavkdsesgesrevahlnfvkwPdhgvPssa

SDLLYFRQAIRAaFPNPTSPMLVHCSAGVGRSGTFIAIDHMLQLILDEAraasdVPDVRDVVHGMRDRRNFMVQTEEQYIFIYFALEMALTA
 .|| | . .|  . . ..|..||||||.|||||.|.|| .|.||  .        ||...|. .|..|. .|||..||||.| |.  .|. 
aellqfvaevrr.lqtdagPivvhcsaGiGrsGtlitidvvlglierdk.....efdvkeivrklreqrqgvvqtkdqyifvykailevlks
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 1237-1494 3.2e-63 208.2 In-house 7-246 (250) alignment 
Range on Protein: 1237-1494
Range on HMM: 7-246/250.0
QANRDKNRYRNITAYDHSRVVLQVNPEEGGCDYYNANYIAGARSPSDYIACQGPTNSSVDDFWRMVWQQKTQCIVMVTNLEEQGRMkCLKYWPdlapgvs
 .|..|||| .| |.|.|||||. .  .  .|| || .. | .  . .|| ||| .... ||||||...|.. |||.|||.|...  . .|||       
pqnkeknryadiialdssrvvLekekgdkesdyinasflhgyderkafiatqgPlqatiedfWrmvleeksgtivmLtnLkesekt.yhqywP.......

ADDlrADelpklQLGPYVVFFKERHEHKLWTQRVFELEHEGEGR-MTVTQFHMTAWPDHGVPSEPSDLLYFRQAIRAAFPN-PTSPMLVHCSAGVGRSGT
..   |.     . |   |  ....|.  .|.|.. | .. .    .| |.| ..||| ||| .    | ... ..|  ..  ..|..|.|||||||||.
vek..ae.....kyGdvtvsllskeefadytkrklklskakkaderivrqlhfvvWPdkgvPevatavLellkkvqasqqqagnaPvivqCsaGvgrsGa

FIAIDHMLqlilDEARAaSDVPDVRDVVHGMRDRRNFMVQTEEQYIFIYFALEMALTAMQ
||||| .|    . ..  . | ||..|.. .|  |  .|...|||.|.| ..  ||....
fiaidavl....erlkk.ekvvdvfkvikvlrkdrphavesleqyvfvyeiilkaldsve
subfamily_PTPN3_pd Subfamily PTPN3 1215-1483 1.4e-62 206.1 In-house 15-268 (280) alignment 
Range on Protein: 1215-1483
Range on HMM: 15-268/280.0
GGLQTEFSRL--QSVGLRHKSCATQANRDKNRYRNITAYDHSRVVLQVNPEeggcDYYNANYIA----GARSPSDYIACQGPTNSSVDDFWRMVWQQKTQ
| . ..| .|  .  ||  . .   .| .|||||.|..||. || |. ..     || ||||.     ..     |||.||| .... |||.|||.||..
Gavlaqfeqlyrkkpglaisaarkpenlsknryrdilpydatrvklkeset....dyinanyvnmeipstglvnryiatqGPlaktatdfWqmvweqkss

CIVMVTNLEEQGRMKCLKYWPDLApgvsaDdlradelpKLQLGPYVVFFKERHEHKLWTQRVFELEHEG-EGRMTVTQFHMTAWPDHGVPSEPSDLLYFR
 |||.|.| |.||.|| .|||.       |        .|..| . |  ....|.| .  | . |...  . . ...|.  .||||||||....|.| | 
livmlttlverGrvkChqyWPete.....d........eleygefsvkcekedetksyvlrelvlkdketkeerkilqlqylaWpdhgvPddsadflefv

QAIRAAFPNPTSPMLVHCSAGVGRSGTFIAIDHMLQLIldEARAASdvpDVRDVVHGMRDRRNFMVQTEEQYIFIY
. .|..    ..|..||||||.||.| .|...  |.||  ||. .     . |.|. |||.|  .|||..|| |. 
ervrklrsgkeePvvvhCsaGigrtGvlilletalali..eaaepv...ypldivrtmrdqramlvqtasqykfvC
subfamily_PTPN9_pd Subfamily PTPN9 1214-1490 1.8e-62 206.1 In-house 15-291 (297) alignment 
Range on Protein: 1214-1490
Range on HMM: 15-291/297.0
EGGLQTEFSRLQSVGL--RHKSCATQANRDKNRYRNITAYDHSRVVLQVNPEEGGCDYYNANYIAGARSPSDYIACQGPTNSSVDDFWRMVWQQKTQCIV
. ||. |.  ...     . .   ..||  |||| ..  ||..||||.  .|.   || |||.. | . .  .|| ||| .  |.|||||||.|..  ||
krGlskeyaeirnepveGtflasklranleknrytdvlcydetrvvlakvdedeasdyinanfvdGykqkkafiatqGplkktvsdfWrmvWeqevlviv

MVTNLEEQGRMKCLKYWPDlapgvsaD-DlRadelpKLQLGPYVVFFKERHEHKLWTQRVFELEHEGE-GRMTVTQFHMTAWPDHGVPSEPSDLLYFRQA
|.| ..|.||.|| .|||.       . .         . | . |   | .|.. ...||.|...  .    .|| | ...|||.||||. ..|| ....
mttrvvergrlkcgqyWpl.......eee.s.....saefgdlsvsnveveeeedykvrvleiknvkteesrkvthfqflsWPdyGvPssaaslldvlek

IRA-------------AFPNPTSPMLVHCSAGVGRSGTFIAIDHMLQLILDEARAasdvpDVRDVVHGMRDRRNFMVQTEEQYIFIYFAL-EMAL
.|              ...    |..||||||.||.||||..|  |. . ... .     ||...|. .| .| |..||.||| | |.|. | ||
vrekqalavkelgdewkghpsgPPivvhcsaGiGrtGtfitldiclsrleevgtv.....dvvetvkllrtqrafsiqtpeqyefcylavleyal
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 1230-1490 3.4e-62 205.1 In-house 35-277 (315) alignment 
Range on Protein: 1230-1490
Range on HMM: 35-277/315.0
RHKSCATQANRDKNRYRNITAYDHSRVVLQVNPEEGGCDYYNANYIAGARSPSDYIACQGPTNSSVDDFWRMVWQQKTQCIVMVTNLEEQGRMKCLKYWP
|.... .. |  ||||.||  .|..||.|.|  ..   ||.|| || .  .   ||| ||| ..|||||||||.|.|.  |||||...|. ..|| .|||
rqrvaretinfkknryknilPldsarvkleviddsPdsdyinasyiksvdddkayiasqgPlkasvddfwrmvlqekvttivmvtkkqegdkikcrqywP

DlapgvsaddLRADelpKLQLGPYVVFFKERHEHKLWTQRVFeLEHEGEGRMTVTQFHMTAWPDHGVPSEPSDLLYFRQAIRAAFPNPTSPMLVHCSAGV
|          .||     ..| . |   . .     ..| .    ..|   |||||..| |||.||. . | || . ....|   . . ..||||||||
d.........rkad...svefGsikvellsleadtdgvarkl.vtrkseesrtvtqfqftewPdkGvdkqtssllklikevkadngkkefsllvhcsaGv

GRSGTFIAIDHMLQLIldeaRAaSDVPDVRDVVHGMRDRRNFMVQTEEQYIFIYFALEMAL
||.| .|.||.... |    .  ... || ..|. .|. | ..|||||.| ||| |.   |
GrtGvvisidevvaqi....kr.trsvdvfnfvknlrakrpylvqteeeyafiydavledl
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 1237-1487 3.8e-62 205.0 In-house 41-273 (515) alignment 
Range on Protein: 1237-1487
Range on HMM: 41-273/515.0
QANRDKNRYRNITAYDHSRVVLQVNPEEGGCDYYNANYIAGARSPSDYIACQGPTNSSVDDFWRMVWQQKTQCIVMVTNLEEQGRMKCLKYWPDLaPGVS
. |  ||||.||  || .|| |.|  ..   ||.|| || .  .   ||| ||| ..|||||||.|.|...  |.|||.|.|. ..|| |||||  || |
einfkknryknilPydsvrvklevindnPhsdyfnasyipsfdndkayiasqgPnkasvddfWrlvlqenvttiamvtklkegdkikcgkyWPdk.pgds

addlradelpkLQLGPYVVFFKERHEHKLWTQRVFELEHEGEgRMTVTQFHMTAWPDHGVPSEPSDLLYFRQAIRAAFPNPTSPMLVHCSAGVGRSGTFI
           ...| . |     .     ..| ... .. .   ||||||.| |||.||| . | || . ....|   . | |...|||||||| | .|
...........vkfGsikvelvsleactggikrkltvlkgdd.srtvtqfhfteWPdkGvpkhtssllklikevkadhgqythpliihcsaGvGrtGvvi

AIDHMLQLIldearAASDVPDVRDVVHGMRDRRNFMVQTEEQYIFIYFALE
.|| ..  .     . ... || ..|. .|..| ..|||.||| ||| |. 
sidsvvaha.....kttrmvdvfnfvtnirqkrpylvqtqeqyafiygavl
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 1237-1488 4.6e-62 204.4 In-house 18-262 (270) alignment 
Range on Protein: 1237-1488
Range on HMM: 18-262/270.0
QANRDKNRYRNITAYDHSRVVLQVNPEEGGCDYYNANYIAGAR-SPSDYIACQGPTNSSVDDFWRMVWQQKTQCIVMVTNLEEQGRMKCLKYWPDlapgv
  ..  |||..|    ..||.|.   |.    |.||||..|.  ..  ||| .||..... .||||.|..|...|||.|.|||.|| || .|||      
argkklnRyadiLPsPatRvrleeleedsataYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkgrkkCerYWpa.....

saddlRADELPKLQLGPYVVFFKERHEHKLWTQRVFELEHEGEGRMTVtQFHMTAWPDHGVPSEPS------DLLYFRQAIRAAFPNP--TSPMLVHCSA
     ...|  ||. |   |.  . . .. . ..  .||..|| |  |  |....|||||||.|.       .||.  .|.|.   .   ..|.||||||
.....epkekvkledgkikvlalseekeegyiltrlrleekgeerrlv.HfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkaePllvHcsa

GVGRSGTFIAIDHMLQLILDEARAasdvpDVRDVVHGMRDRRNFMVQTEEQYIFIYFALEM
||||.||.||.|....|.  . ..     ||  ... .|  |  .||. ||| |.| |. .
GvgRtGtlialDiavrlLeetkkv.....dvlaiieelRkdRmalvqhpeqyeflykavve
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 1208-1489 5.1e-61 201.3 In-house 17-278 (315) alignment 
Range on Protein: 1208-1489
Range on HMM: 17-278/315.0
QSKLDAEGGLQTEFSRLQSVGLRHKSCAT-QANRDKNRYRNITAYDHSRVVLQVNPEEGGCDYYNANYIAGARSPSDYIACQGPTNSSVDDFWRMVWQQK
| |  .. |.. ..  .    |.    |    |..|||| || |||.||| | .   . ..|| |||.| |   .  |||.|||  .||.||||.|....
qkkastkngfkqdyesipggqlhpldvakkienkqknryiniiaydksrvqlpllendphsdyvnanfidGynkkrryiaaqgpnvasvkdfwrlvfeed

TQCIVMVTNLEEQGRMKCLKYWPDLapgvsaddlradelpKLQLGPYVVFFKERHEHKLWTQRVFELEHeGEGRMTVTQFHMTAWPDHGVPSEPSDLLYF
   |||.||| |. . |. |||||                |.  |.. |  |.   .. .| | .     |.   .| |.|.|.||| |||     |. .
igkivmltnlvegekrkaekywpdk...............kviyGkitvtrkseevnteytvrtlsvvf.gdnirevvqlhytswpdmgvpkytiplmnl

RQAIRAAFPNPTSPMLVHCSAGVGRSGTFIAIDHMLqlilDEARAaSDVPDVRDVVHGMRDRRNFMVQTEEQYIFIYFALEMA
 . ..    |  ....|||||||||.||||..| .|    |.| |  .. || ....|.|. |  |||. ||| ||| ||  .
irtvkqhhtnsvgaivvhcsaGvGrtGtfitldavl....dqaea.enaidvynfitgvrqnrikmvqvaeqyqfiydallet
subfamily_PTPN1_pd Subfamily PTPN1 1228-1486 2.6e-58 192.0 In-house 21-267 (290) alignment 
Range on Protein: 1228-1486
Range on HMM: 21-267/290.0
GLRHKSCATQANRDKNRYRNITAYDHSRVVLQVNPEeggcDYYNANYIAGARSPSDYIACQGPTNSSVDDFWRMVWQQKTQCIVMVTNLEEQGRMKCLKY
 ...... ...||..||||... |||||..|. .      || ||. .   .    ||  |||  . || ||.|||.||....||. .. |....|| .|
dfptreaklpenrnlnryrdvspydhsrikleradn....dyinaslveleeakrsyiltqGPlpntvdhfWqmvWeqkskavvmlnkvvekeqikcaqy

WPDLAPgvsaddlrADELpKLQLGPYVVFFKERHEHKLWTQRVFELEH-EGEGRMTVTQFHMTAWPDHGVPSEPSDLLYFRQAIRAA--FPNPTSPMLVH
||             .|| .|.   . | . ...... .| |..|||  . .   ....|| |.||| |||. |. .| | . .| .  . .   | ..|
wPqgee........ekel.lledtklkvkliseerksyytvrllelenlktqetreilhfhyttwpdfgvpespaaflkflfkvresGslssdvGpavih

CSAGVGRSGTFIAIDHMLQLIldEARAASDVPDVRDVVHGMRDRRNFMVQTEEQYIFIYFAL
||||.||||||. .| .| ||  |..   .  |...|.  .|  |  ..|| .|  | |.|.
csaGiGrsGtfclvdtclvli..ekkddlssvdikkvllelrkyrlGliqtadqlrfsylai
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 1216-1487 3.4e-58 192.4 In-house 35-288 (319) alignment 
Range on Protein: 1216-1487
Range on HMM: 35-288/319.0
GLQTEFSRLQSVGLR---HKSCATQANRDKNRYRNITAYDHSRVVLQVNPEEGGCDYYNANYIAGARSPSDYIACQGPTNSSVDDFWRMVWQQKTQCIVM
 |. || |.  .|      . .  . |.||||. || |.|...| |.    | . || || ...| ...  |||.||| . ...|||||.|....  ||.
klevefrracklgvnladqtfanldqnkdknriinilafdknvvklerliGeefsdyinasfvtGyqrkdkyiaaqGPldntladfWrmiweyncstivl

VTnleeqgRMKCLKYWPDlaPGVSaddlrADELPKLQlgpyVVFFKERHEhklWTQRVFELEHEG--EGRMTVTQFHMTAWPDHGVPSEPSDLLYFRQAI
.|      . || .|||    .|       .|  |..    |   .| .|   .. | .|| ..|  ..   .||||.  |||.|||  ||||. . . .
lt......kdkcsqywpl..kivi.....keerfkvk....vdsveetae...yvvrdielsedgkekdirkitqfhflGwpdvGvpdypsdlmrlvkkv

RA--AFPNPTSPMLVHCSAGVGRSGTFIAIDHMLQLILDEARAasdvpDVRDVVHGMRDRRNFMVQTEEQYIFIYFALE
|      |   ...|||||||||.|..|..| .|. . .| .      || ..|...|..|| .||   || ||| || 
rhltskenhranivvhcsaGvGrtGvyivldvlldrmkeekqv.....dvynfvrdlrqqrntlvqdlvqykfiysall
subfamily_PTPN23_pd Subfamily PTPN23 1207-1488 2.3e-57 189.0 In-house 7-279 (288) alignment 
Range on Protein: 1207-1488
Range on HMM: 7-279/288.0
LQSKLDAEGGLQTEFSRLQSVG---LRHKSCA-TQANRDKNRYRNITAYDHSRVVLQvnpeEGGCDYYNANYIAGARSPS-DYIACQGPTNSSVDDFWRM
 ...|| ...|...|  |..      |..|.|  . . .|||.|.|  |||.||.|.    ..  || || .. .  . . |.|| |.| .|.. |||.|
qrkmldgktaldkkfkeleqkqdkearkrsiaiaklyseknrsrdilPyDhnRvklr....gskDDYinAsfvkdlspgcPdfiatqaPlqstlnDFWlm

VWQQKTQCIVMVTNLEEQGRMKCLKYWPDLA-PGVSADDlradelpklqlgpYVVFFKERHEHKLWTQRVFELEHEGEGRM-TVTQFHMTAWPDHGVPSE
|..||.. |||... ||.|. |. .|||      |. .|             . |  |. .| . . .||..||.... .. .|.  ..|.||..|||. 
vyeqkssviVmllskeelgkpkvdrYwPedkgetvkfgd.............lsvtlksvretethvervlkletldadavksvshlqltsWpelGvPas

PSDLLYFRQAIRAAFP----NPTSPMLVHCSAGVGRSGTFIAIDHMLQLIldeaRAASDVPDVRDVVHGMRDRRNFMVQTEEQYIFIYFA-LEM
|..|| | .....|.     .   |..|||||||||.|.|  .   .. .    ..   ..|. .||. .|  | ||||..||. | | | || 
PetllqfldevesayeavqrksktPlvvhCsaGvgRtgvfalvyaavrel....ekgnglldiiqvvsrlreqRrfmvqekeqlkfsyeavlea
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 1235-1487 5.6e-57 188.4 In-house 21-252 (284) alignment 
Range on Protein: 1235-1487
Range on HMM: 21-252/284.0
ATQANRDKNRYRNITAYDHSRVVLQVNPEEGGCDYYNANYIAGARSPSDYIACQGPTNSSVDDFWRMVWQQKTQCIVMVTnleeqgRMKCLKYWPDLApg
  . |.||||. .| |.|...| |.    | . || || .|.| ...  |||.||| . ...|||||.|....  ||..|      . || .|||  .  
nldqnkdknrighilafdknvvklerliGeefsdyinasfitGyqrkdkyiatqGPldntladfWrmiweyncstivllt......kdkcsqywplki..

vsadDlRADELPKLQlgpyVVFFKERHEhklWTQRVFELEHEG--EGRMTVTQFHMTAWPDHGVPSEPSDLLYFRQAIRA--AFPNPTSPMLVHCSAGVG
    .   .|  |..    |   .| .|   .. | .|| ..|  ..  ...|||.  |||.|||  ||||. . . .|      |  ....||||||||
....v.ikeerfkvk....vdsveesee...yvvrdielsedgkekdirkirqfhflgwpdvgvpdypsdlmrlvkkvrhltskenhranivvhcsagvg

RSGTFIAIDHMLQLILDEARAasdvpDVRDVVHGMRDRRNFMVQTEEQYIFIYFALE
|.|..|..| .|. . .| .      || ..|...|..|| .||   || ||| || 
rtgvyivldvlldrmkeekqv.....dvynfvrdlrqqrntlvqdlvqykfiysall
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 1218-1488 8e-57 187.4 In-house 8-266 (274) alignment 
Range on Protein: 1218-1488
Range on HMM: 8-266/274.0
QTEFSRLQSVGlRHKSCATQANRDKNRYRNITAYDHSRVVLQV-NPEEGGCDYYNANYIAGARSPS-DYIACQGPTNSSVDDFWRMVWQQKTQCIVMVTN
..||  | .    ..      .  ||||..|   ..|||.|.  ..|.   .| ||||| | .  |  |.| |||  . |.|||||..|...| |||.|.
ekeflelPlnf.dqeeldvfgsqtknryktilPnensrvllesessededssyinanyikGydeeskayvatqGPlpntvadfWrmiyqeevqvivmltk

LEEQGRMKCLKYWPDLAPG-VSADDLRADelpklqlgpyvVFFKERHEHKLWTQRVFELEHEGEgRMTVTQFHMTAWPDHGVPSEPSDLLYFRQAIRA--
|.|. . || .|.||     .|      .           . ...  |.. .. | . |..  . . .|. .  |.|||| .| ... || . . ..   
lkeaneqkCavyfPdaedyeiserygdve...........ikvekiverndysvrklvlkyler.ersvkhywytdWPdhksPddantlldlvleveesr

-AFPNPTSPMLVHCSAGVGRSGTFIAIDHMLQLILDearaaSDVPDVRDVVHGMRDRRNFMVQTEEQYIFIYFALEM
 .  ....|..||||||.|| | ||||.  .. . .     . | ||  .|  .|  |  ||||.||| .|. || .
eeenaklapvvvhCsaGiGrtGcfiaisiavrqlre.....eivvdvlkivcnlrldrGGmvqtseqyelihralcl
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 1239-1484 2.1e-56 185.8 In-house 3-233 (237) alignment 
Range on Protein: 1239-1484
Range on HMM: 3-233/237.0
NRDKNRYRNITAYDHSRVVLQVNpeEGGCDYYNANYIAGA-RSPSDYIACQGPTNSSVDDFWRMVWQQKTQCIVMVTNLEEQGRMKCLKYWPDlapgvsA
|. |||| ||.|||||||||. .   .|.|| ||.|. |   .|  |||.||| .|| ||||.||||.|   |||.| | |. ..|| ||||.      .
nkiknrygnivaydhsrvvlkga..gsgsdyinatylkgfdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywps......t

DDlradelPKlQLGPYVVFFKERHEHKLWTQRVFELEHEGE--GRMTVTQFHMTAWPDHGVPSEPSDLLYFRQAIRAAFPN--PTSPMLVHCSAGVGRSG
|.      |.   | . | .| . |   .| | . | ....  .   . |...|.|||.||| . . || ||. |    |    ..| ..||||||||.|
dq......pa.aygvltvslkkkeefsdytvrslllskrltlkevrlihqyqftswpdrgvpqqtaallrfrkniinrsphvsesgpwiihcsagvgrtg

TFIAIDHMLQlildEARAaSDVPDVRDVVHGMRDRRNFMVQTEEQYIFIYF
 |. || ||.    .|.    | |. . |. . . | ...||..||.||. 
iflvidamlr....qake.kkvvdiynyvysieedrpyiiqtkdqyvfihq
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 1204-1490 2.3e-56 186.3 In-house 11-288 (325) alignment 
Range on Protein: 1204-1490
Range on HMM: 11-288/325.0
LQHLQS-KLDAEGGLQTEFSRLQSVGLRHKSCAT-QANRDKNRYRNITAYDHSRVVLQVNPEEGGCDYYNANYIAGARSPSDYIACQGPTNSSVDDFWRM
..|..  | . . |.  ||  | |..   |  |.  .|..|||..|. |.|.|||||.   ... .||.||.|.   .    ..|.| |  ....|.||.
vehvekkkaqdqdgfahefgllpsddgiakkvamkpenkaknrfknvvaldksrvvletkkddpssdyinasylrddkkkdvflaaqaPltatindlWrl

V--WQqktQCIVMVTNLEEQGRMKCLKYWPDLApGVSaddlradelpkLQLGPYVVFFKERHEHKLWTQRVFELEHEGEG-RMTVTQFHMTAWPDHGVPS
|  |.     .|.|.|  ..|  .| .|||.   | |            ..|.  | ..   |   . .||...    .|  ..| ||.. .|.| ||. 
vldWr...csvvvvlneldlgkdrcavywpkem.gks...........ktfGglevklrtieeisdyvhrvldvkqvkkGetrsvkqfqlqswddmGvqk

EPSDLLYFRQAIRAAFP------NPTSPMLVHCSAGVGRSGTFIAIDHMLQLILDEARAasdvpDVRDVVHGMRDRRNFMVQTEEQYIFIYFALEMAL
 |. |. . | . |         . ..|.||||||||||.|.||..  .|. ...|.|      |. ..|. .|  |  ||.| .|||.|| ||  |.
rpatlisilqlvkavservtantkastpilvhcsaGvGrtGvfislysalakvieesrv.....difgfvkklrkdrpsmvetvdqyiliyealveay
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 1235-1494 4.8e-56 185.1 In-house 46-288 (297) alignment 
Range on Protein: 1235-1494
Range on HMM: 46-288/297.0
A-TQANRDKNRYRNITAYDHSRVVLQVNPEEGGCDYYNANYIAGARSpsDYIACQGPTNSSVDDFWRMVWQQKTQCIVMVTNLEEQGRmKCLKYWPDLAp
|  . | .|.||.||  || ||| |..  ..   || || .. | .    .|. | | ...|.|||.||...... |||.....|. . || .||.| . 
aekkvnfeksRYkniLPydssRvkLaivnddpdsDyvnasfvkgnkh..rlittqmPmkatvadfWamvldeqvstivmlnddnerdk.kcaryWsdkg.

gVSAddlradelpklqLGPYVVFFKERHEHKLWTQRVFELEHEG-EGRMTVTQFHMTAWPDHGVPS--EPSDLLYFRQAIRAAFPNPTS-PMLVHCSAGV
 |..            .|  .|  .  .| .   .| .|....    |  | |.. . |||. |.   . | || . . .|  | . .. |.||||.|||
.vtt............fGdvsvvllsvsereGfikrelevtkgkakarrvvkqyqfveWPdkaverkdsassllklisevrkdfsqnaegPllvhclaGv

GRSGTFIAIDHMLQlildEARAASDVpDVRDVVHGMRDRRNFMVQTEEQYIFIYFALEMALTAMQ
|| | ...|| ..     ||.   .| |. ..|. .|. | ..|||.||| |.| |.  || . .
Grtgvlltidsvva....eakrekev.difglvkklrqerpylvqtkeqykfvyvavleallsed
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 1214-1494 1.9e-55 182.9 In-house 19-282 (287) alignment 
Range on Protein: 1214-1494
Range on HMM: 19-282/287.0
EGGLQTEFSRLQSVGLRHKSCA---TQANRDKNRYRNITAYDHSRVVLQvnpeEGGCDYYNANYIAGARSPSDYIACQGPTNSSVDDFWRMVWQQKTQCI
. | .. |  |..|. |...     .. |.||||...|  .|  ||.|.    .   || || .| | ..   .|....|  . . .||....... . |
negfknqftvleqvtqredevthniasqnkdknRltqilvpdnyrvllk....gehpdyinavfidgykekkafiiaesPmfntarnfWkliddrnvtai

VMVTNLEEQGRMKCLKYWPDlapgvsADdlradelpKLQLGPYVVFFKERHEHKLWTQRVFELEHEG--EGRMTVTQFHMTAWPDHG-VPSEPSDLLYFR
||.....|. . .| .|||.       .         . ||.| . . ... .. ...| .|.....  . . .|.|...|.|...| |..  . || . 
vmlcqekendeevcyqyWpe......ek........svvlGeyniellneevnagyierklevknknkagdkqqvkqyqitnWdstgkvtepqtillvie

QAIRAAFPNPTSPMLVHCSAGVGRSGTFIAIDHMLQLILDEAraasdVPDVRDVVHGMRDRRNFMVQTEEQYIFIYFALEMALTAMQ
. ...   .  ....||||..||||..|.|..  ..    |      | || .|.. .| ..  .||| |||.||. .. . |....
emyktqrkrgntsivvhCsdtvGrsamfcaaattinkckteG.....viDvfqvlksqriqkpgsvqtveqykfindivleyldsfe
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 1211-1493 5.8e-55 181.2 In-house 16-286 (290) alignment 
Range on Protein: 1211-1493
Range on HMM: 16-286/290.0
LDAEGGLQTEFSRLQSVGLRHKS--CATQANRDKNRYRNITAYDHSRVVLQVNPEEGGC--DYYNANYIAGARSPSDYIACQGPTNSSVDDFWRMVWQQK
   . | ...| .|.|    |.     |. |. .||..||  ||  |..|.  ...  |  .| || || | .   .||| |||... . |||...||.|
akgnegfrnqfkmldsgesehtvtvgltssnkllnRfanivvyddnritLrpisghkDCtneyinAcyikgykekkqyiatqgpvsntlvdFWkliwqek

TQCIVMVTNLEEQGRMKCLKYWPDLAPGVsADDLRADElpklqlgpyvvffKERHEHKLWTQRVFELEHEGE--GRMTVTQFHMTAWPDHG-VPSEPSDL
. .|||.||  |.|. || .||||       .  .                 . ....  ..| .|.... .   . .|||...|.|...| |. . . |
vtiivmltniieegkvkCqqYWpdsdtka.ygefsikl.............lneetlneyierklevknknsagakqsvtqyqitnwdstgkvtnpqtil

LYFRQAIRAAFPNPTSPMLVHCSAGVGRSGTFIAIDHMLQLILDEaraasDVPDVRDVVHGMRDRRNFMVQTEEQYIFIYFALEMALTAM
| ... ..  . .   ...||||..||||..|.|..  ..    |      | || .|.. .|  .  .|||..|| .|.  .  .|. .
lvieemyktqrkrgntsivvHCSdtvgrsavfcaaattinkckte.....gvidvfqvlksqRiqkpgsvqtvqqyqgifqivltyldsf
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 1231-1486 1.2e-54 180.2 In-house 37-232 (392) alignment 
Range on Protein: 1231-1486
Range on HMM: 37-232/392.0
HKSCATQANRDKNRYRNITAYDHSRVVLQVNPEEGGCDYYNANYIAGARSPSDYIACQGPTNSSVDDFWRMVWQQKTQCIVMVTNLEEQGrmkclkywpd
.... .. |  ||||.||  || .||.|.|  .    ||.|| || .  .   |||.|||  .|.|||||||.|...  |.|||.|.|            
qtvaqkeinlkknryknilpydsarvkleviddipdsdylnasyipsfdnekayiasqgpnaaslddfwrmvfqenvttiamvtklkegd..........

lapgvsaddlradelpklqlgpyvvffkerhehklwtqrvfelehEGEGRMTVTQFHMTAWPDHGVPSEPSDLLYFRQAIRAAFPNPTSPMLVHCSAGVG
                                              |.   ||.|||.| |||..||   | || | . ..| | . | |...|||||||
.............................................kgddartvaqfhftewPdkdvpkhtssllkfikevkadfGqythpliihcsagvg

RSGTFIAIDHMLqlilDEARAASdVPDVRDVVHGMRDRRNFMVQTEEQYIFIYFAL
|.|  |.|| ..      |. .  . || ..|  .| .| .||||.||| ||| |.
rtgvvisidsvv....ahakktr.mvdvfnfvtnirrkrpymvqtkeqyafiygav
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 1234-1487 2.6e-51 169.4 In-house 43-276 (439) alignment 
Range on Protein: 1234-1487
Range on HMM: 43-276/439.0
CATQANRDKNRYRNITAYDHSRVVLQVNPEEGGCDYYNANYIAGARSPSDYIACQGPTNSSVDDFWRMVWQQKTQCIVMVTNLeeqgrMKCLKYWPDLAP
 | . .. ||||....|.||.||.||  |      |.||||| |   .  |||.|||.. ..|||||.|...||  |||.|||     ..  ||||  | 
aaqeydqtknrykdvgafdhtrvtlqeipgvphshyinanyikGyyddklyiatqgpkkettddfwrlviekktvtivmltnl.....vesykywpsdae

GVSAD-DLRADElpKLQLGPYVVffkerHehklwTQRVFELEHEGEGRMTVTQFHMTAWPDHGVPSEPSDLLYFRQAIRAAFP-NPTSPMLVHCSAGVGR
 .  |  .|.|   ...|  ||.     .       .||.    .|   || ||| .||||. ||.. | .| | .|| .|   . . |..|||||||||
vcygdiavrvdr..nielpnyvi.....r.....gfkvfnerdttekertvlqfhyiawpdknvpaqashvldflrainsandkeeygpvvvhcsagvGr

SGTFIAIDHMLQLILDEARAasdvpDVRDVVHGMRDRRNFMVQTEEQYIFIYFALE
.|| ||.|  |. .  | .      |.. .|. .|..|. |||.  ||.||| |. 
tGtiialdialeqlklenkv.....dikgivkvlrkqrkqmvqalcqyvfiynavl
subfamily_PTPN14_pd Subfamily PTPN14 1198-1486 3.4e-51 169.0 In-house 7-292 (300) alignment 
Range on Protein: 1198-1486
Range on HMM: 7-292/300.0
EKVDAILQHLQSKLDaEGGLQTEFSRLQSVGLR--HKSCATQANRDKNRYRNITAYDHSRVVLQVNPEEgGCDYYNANYIAGA--RSPSDYIACQGPTNS
.  |.  ..|. ||. || . ||. |..   .    .... . | .|||....  |...|| |. . |.   .| ||  |  .   .  .||..||| . 
atkdkrakilekkle.egkvfteyeripkkredallstaklpenaeknrfkdvlPyednrvelsptken.stgyinassikvsvggkersyivaqgPlel

SVDDFWRMVWQQKTQCIVMVTNLEEQGRMKCLKYWPDLApgvsaddlraDELPKLQLGPYVVFFKERHEHKLWTQRVFELEHEGEG-RMTVTQFHMTAWP
 | |||.|||.|..| |||.|. ||.|. |..||.|.|           ..  ... | . |  | ... .  . . ..|.|   . . ||  .  | ||
tvqdfWqmvWeqgvqlivmlteeeedgkeksfkyfPkle..........skkktvefgkfkvttkfsedsdsvittglklkhlpskeertvwhlqytDWp

DHGVPSEPSDLLYFRQ---AIRAAFPNP------TSPMLVHCSAGVGRSGTFIAIDHMLQLIlDEaraaSDVPDVRDVVHGMRDRRNFMVQTEEQYIFIY
|||||..... | . .   ..| .. .         |.||||||||||.|  |  | ... . .      .. |.. |.. .| .| ..|||  || |.|
dhgvPeDvkgflsyLeevqsvrrktnseveskeskPPvlvhCsaGvGrtGvlilsdlliatl.eh....neeidikkvlarLreqrmllvqtlaqYkfvY

FAL
 .|
kvl
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 1217-1493 3.4e-50 165.4 In-house 17-296 (301) alignment 
Range on Protein: 1217-1493
Range on HMM: 17-296/301.0
LQTEFSRLQSVGLRHKS-CATQANRDKNRYRNITAYDHSRVVLQVNPEEGGC--DYYNANYIAGARSPSDYIACQGPTNSSVDDFWRMVWQQKTQCIVMV
.. ....|...  .. .   ...|.  ||..||| ||. |..|. .|.   |  .| ||.|| | ..   .|| ||| .. . ||||..||.|.. ||||
feeqykelkegedksctvglseenkalnrfknitvyddnriilkpkpnldlcqreyinasyidgysekkkfiaaqgpmkktlvdfWrliwqekpvsivmv

TNLEEQGRMKCLKYWPDLAPGVSADDLRA------DELPKLQLGPYVVFFKERHEHKlWTQRVFELEHEGeGRMTVTQFHMTAWPDHGVPSEPSDLL-YF
|||.|. . || .|||.     .              .|   .    |  ..  ...  ..| |. ...    ..|.|...| ||..||  ||   |   
tnlkegtkskceqywpnseaeseefgpftvtlvneqvyPdfvirqlnvkiqdgsnng.yierkfkvksdk.sswdvlqlqvtdWpqdGvvreprtvLqvi

RQAIRAAFPNPTSPMLVHCSAGVGRSGTFIAIDhmlqLILDEARaASDVPDVRDVVHGMRDRRNFMVQTEEQYIFIYFALEMALTAM
 . | .      .|..||||..|.|||......    . |. .. |  | || .|.. .|  .  .|.| |||..|| ...| |.  
ddvihrqqkigggpvvVHCSdtVsrsGvYcsvs....iglEQck.aegVVdvfqvtkavrrskpgaVtTLeqytsiydvidmylqln
subfamily_PTPRN_pd Subfamily PTPRN 1202-1486 8.5e-49 160.9 In-house 16-288 (297) alignment 
Range on Protein: 1202-1486
Range on HMM: 16-288/297.0
AILQHLQSKLDAEGGLQTEFSRLQSVGLRHKSC---ATQANRDKNRYRNITAYDHSRVVLQVNPEEGGCDYYNANYIAGA--RSPsDYIACQGPTNSSVD
 .|..|. .|  .  |. |.  | .     ...    .. | .|||.... .|||||| |. . ..   || ||  |     |.|  |||.||| .|.| 
vvlsyledhlknkdrlekewealcayeaepstkevakaeknvkknrskavlpydhsrvklkeeasaeksdyinasaildhdprap.ayiatqgplastva

DFWRMVWQQKTQCIVMVTNLEEQGRMKCLKYWPDLapGVSADdlradELPKLQLGPYVVFFKErhehklWTQRVFELEH-EGEGRMTVTQFHMTAWPDHG
|||.|||.| .  ||..|.|||.|  .| .||||   | .       .. ...|    .. ..      .  | | |   . .   ||||||  .||..|
dfwqmvweqGvvvivnltrleeegvkqckrywpde..Gsevy.....hiyevhlvsehiwcdd......ylvrsfylknlqtsetrtvtqfhflswpeeg

VPSEPSDLLYFRQAIRAAFPNPTSPMLVHCSAGVGRSGTFIAIDHMLQLILDEARAAsdvpDVRDVVHGMRDRRNFMVQTEEQYIFIYFAL
||...  || ||. .  ..   ..|..||||.|.||.|..|.|| .|. .|  ..      |.   .  .||.|. .|.|..|. |.. |.
vPasaksllefrrkvnksyrGrscpivvhcsdGaGrtGvyilidlvlnrllkGvkei....diaatlehlrdqrpglvktkdqfefaltav
0041856 (Phosphotyrosine protein) phosphatases II 1239-1486 1.2e-48 160.4 In-house 1-167 (182) alignment 
Range on Protein: 1239-1486
Range on HMM: 1-167/182.0
NRDKNRYRNITAYDHSRvvlqvnpeegGCDYYNANYIAGARSPSDYIACQGPTNSSVDDFWRMVWQQKTQCIVMVTnleeqgrmkCLKYWPDLApgvsad
|.|||||..|  |||||          ..|| |||...|.. ....||.|||..|.| ||.||..... ..||..|         .  |||.|       
nldknrysdilpydhsr..........dldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt.........eelywpell......

dlradelpklqlgpyvvffkerhehklwtqrvfelehegegRMTVTQFHMTAWPDHGVPSePSDLLYFRQAIRAafpnPTSPMLVHCSAGVGRSGTFIAI
                                           ...|.. . |||||||. ...|| | .....    .  | ||||||||||.||..|.
.........................................erlgiqylylpwpDhgvpd.ldelldfieevle....eggpvlVHCsaGvgRtgtlvaa

DHMLQLildearaasDvPDVRDVVHGMRDRRNFMVQTEEQYIFIYFAL
. |..|         .  .....|. .| ||. ||.|..||.|.. ||
ylmkkl.........g.vsleeavklvrsrRpgmvitpnqyfflqlal
0051429 (Phosphotyrosine protein) phosphatases II 1268-1511 2.3e-48 160.5 In-house 5-246 (272) alignment 
Range on Protein: 1268-1511
Range on HMM: 5-246/272.0
DYYNANYIAGARS---PSDYIACQGPTNSSVDDFWRMvWQQKTQCIVMVTNLEEQGRMKCLKYWpdlaP--GVSADDLRADELPKLQLGPYVVFFKERHE
.|.||... |  .   |  .....||.. ...||||. ....  .||.....||.|| || .||    |   .   ..  |. |   .| ..|.. . . 
gyiNardvggygrvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdryw....pgirylhlpilddsaptilygalrvtllseel

HKLWTQRVFELEHE---GEGrMTVTQFHMTAWPDHGVPSEPsdLLYFRQAIRAafpnpTSPMLVHCSAGVGRSGTFIAIDHMLQLIldearAASDVPD--
.  .. |...|...   ||. ..|...|.|.|||||||.|.  || . .....       |.|||||||..|.||..|....|. .      .... |  
lldyilrellltlllsagea.revmhlhytdwpdhgvpqea..llellellld.....ggpvlvHCsaGkdRTGtvvallllllgv.....sletivddY

------VRDVVHGMRDRRNFMVQTEEQYIFIYFALEMALTAMQATDKADLKMALDEFHQH
      ....|. .|..|  .|||||||.|.| ||  .| ...... . |..|||.....
lltnlyleeaveelraqrpgavqteeqylflyeallellrsllsvraeyllaaldaidee
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 1237-1486 3.6e-48 158.8 In-house 5-236 (239) alignment 
Range on Protein: 1237-1486
Range on HMM: 5-236/239.0
QANRDKNRYRNITAYDHSRVVLQVNPEEGGCDYYNANYIAG-ARSPSDYIACQGPTNSSVDDFWRMVWQQKTQCIVMVTNLEEQGRMKCLKYWPDLAPGV
. |. |||| || .||||||||.   ..   || ||.|.     ||  ||| ||  . |  |||||.||..   |||.| | |  . || .|||| .   
rvnkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdstsky

SadDLRADeLPKLQlgpyvVFFKerhehklWTQRVFELEHEG--EGRmTVTQFHMTAWPDHGVPSEPSDLLYFRQAIRAAFPNPTSPMLVHCSAGVGRSG
   .||   | | .     ||         .  | | . . |  | |  | |.|.| |||.|||   . .| .|. |       . | ..||||||||.|
c..nlrvt.lrkte.....vfad.......yiirtfvmsqvgqteer.yvyqyhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcsagvgrtg

TFIAIDHMLQlildEARAASDVpDVRDVVHGMRDRRNFMVQTEEQYIFIYFAL
.|. || ||.    .|.    | |. . |. .|. | .|||| |||.||..|.
aflvidamlr....qakkqktv.difnyvkairedrphmvqtseqyvfihlav
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 1237-1486 4e-48 158.6 In-house 6-237 (239) alignment 
Range on Protein: 1237-1486
Range on HMM: 6-237/239.0
QANRDKNRYRNITAYDHSRVVLQVNPEEGGCDYYNANYIAG-ARSPSDYIACQGPTNSSVDDFWRMVWQQKTQCIVMVTNLEEQGRMKCLKYWPDLAPGV
. |. |||| || .||||||||.   ..   || ||.|.     ||  ||| ||  . |  |||||.||..   |||.| | |  . || .|||| .   
rvnkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdstsky

SadDLRADeLPKLQlgpyvVFFKerhehklWTQRVFELEHEG--EGRmTVTQFHMTAWPDHGVPSEPSDLLYFRQAIRAAFPNPTSPMLVHCSAGVGRSG
   .||   | | .     ||         .  | | . . |  | |  | |.|.| |||.|||   . .| .|. |       . | ..||||||||.|
c..nlrvt.lrkte.....vfad.......yiirtfvmsqvgqteer.yvyqyhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcsagvgrtg

TFIAIDHMLQlildEARAASDVpDVRDVVHGMRDRRNFMVQTEEQYIFIYFAL
.|. || ||.    .|.    | |. . |. .|. | .|||| |||.||..|.
aflvidamlr....qakkqktv.difnyvkairedrphmvqtseqyvfihlav
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 1225-1487 2e-45 149.8 In-house 24-274 (287) alignment 
Range on Protein: 1225-1487
Range on HMM: 24-274/287.0
QSVGLRHKSCATQANRDKNRYRNITAYDHSRVVLQVNPEEgGCDYYNANYIAGARSPSDYIACQGPTNSSVDDFWRMVWQQKTQCIVMVTNLEEQGRMKC
.|. .  |.    |.  |||| ..  .|..||.|  ..|  | || ||||.|. .    .||.|||  ..| ||||.|.....  ....|   |..|.||
esstatfkaaeelaavkknryadvlPiddtrvllsaegel.GsdyinanyvasytddeafiaaqgPiaatvrdfwravletrsasvitmtreveearlkc

LKYWPDlapgvsaddlRadELPkLQLGPY-VVFFKERHEHKLWTQRVFELEH-EGEGRMTVTQFHMTAWPDHGVPSEPSDLLYFRQA----IRAA-FPNP
 ||||.          |  | | ...| | || ..    .  .. | . | . |..    | |... .|||....     |. |       | .|   . 
ykywPe..........r..evP.mrvGGysvvlldydikePeygvralrlidletrearvvkqldllswPdkvlaPtavglirfvldvkqhielardase

TSPMLVHCSAGVGRSGTFIAIDHMLQLILDEARAasdvpDVRDVVHGMRDRRNFMVQTEEQYIFIYFALE
. |..||...|.||||...|.  ...  .|  |      ||  ||  .| .|. .||.  |. ..| || 
vGPlvvhddvGiGrsGillatlvlvsrledlGrv.....dvaavvirlreyraalvqavvqlrllyealv
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 1219-1485 2.2e-45 150.0 In-house 20-272 (307) alignment 
Range on Protein: 1219-1485
Range on HMM: 20-272/307.0
TEFSRLQSVGLR-HKSCATQANRDKNRYRNITAYDHSRVVLQVNpeEGGCDYYNANYIAGARSPSDYIACQGPTNSSVDDFWRMVWQQKTQCIVMVTNLE
 ||. |           | .|| |||||... . |..|.|....      ||  |||.  |  |  .|..||| .... .|| |. |.| ....|. .. 
defrvlakktpegvtveafsantdknryqdvkcqdkgrivvkfd..glasdyihanylgiaikpkkficaqgplentqysfwamaiqekvesvimlckvi

EQGRMKCLKYWPDLAPGVSADDLRADELPKLQLGPYVVffkeRHEHKLWTQRVFELEHEGEGRmTVTQFHMTAWPDHGVPSEPSDLLYFRQAIRAAfpnp
| ...|| .|||       .   ... .   .||   .      ...|     ....  .. | |....  . |||.|||      . . .|.|      
elakikceqywpleegqklvfgeapntisvanlgakkl....apdedlinvttlkvdwaqksr.tiqhlqwenwpdrgvpqinltainlleavryd....

TSPMLVHCSAGVGRSGTFIAIdhmlQLILDEARAASDVPDVRDVVHGMRDRRNFMVQTEEQYIFIYFA
| |..|||||||||||| .||     |. |   |  .  |....|. .|..|.. .||| ||....  
tnpvvvhcsaGvGrsGtivai....slvqdkmiaGinckdmkklveelrsqrhyaiqteaqylylhrv
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 1222-1494 8.4e-44 144.5 In-house 16-271 (283) alignment 
Range on Protein: 1222-1494
Range on HMM: 16-271/283.0
SRLQSVGLRHKSCATQANRDKNRYRNITAYDHSRVVLQVNPEeggcDYYNANYIA---GARSPSDYIACQGPTNSSVDDFWRMVWQQKTQCIVMVTNLEE
 ||    |  .  ... |. |||...| ..|  || |. ...    || || .|      .   .||..|.| .  | |||.||...|  .|||.|.| |
krlsvpdldadiasadenkrknrnqeivpadqwrvelksesr....dyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfdekitaivmltklqe

QGRMKCLKYWPDlaPGvsaddlradelpKLQLGPYVVFFKERHEHKLWTQRVFELEHE--GEGRMTVTQFHMTAWPDHGVPSEPSDLLYFRQAIRAAFPN
. |.|| .|||    |              . |.. |  ..   .. .... . | ..   .  . .. . .  | . |  .    |. | . |     .
dlrikCsqyWPk..rG............sedyGeftvtlrkettsnsfiikelllrvnssakstlllahyqvidWleygeqaiinslvkfnkvislqtes

PTSPMLVHCSAGVGRSGTFIAIDHMlqliLDEARAASdVPDVRDVVHGMRDRRNFMVQTEEQYIFIYFAL-EMALTAMQ
. .|..||||.|.||...|||.       ...|.. | | ||  ||. || .|  .||| .|| ... .  | ||    
kkgPivvhCstgiGrtavfiaasas....vkdaltes.vvdvfavvkimreqrmmavqtldqyklvhelvleqalcgdt
0036282 (Phosphotyrosine protein) phosphatases II 1267-1483 1.7e-43 143.7 In-house 2-163 (174) alignment 
Range on Protein: 1267-1483
Range on HMM: 2-163/174.0
CDYYNANYIAGARSPSDYIACQGPTNssvddFWRMVWQQKTQCIVMVTNLEEQGRMKCLKYWPDlapgvsaddlradelpklqlgpyvvffkerhehklw
 ||.||... . . .. .||.|||..     ||.|..... ...||.....| |. ||  |||.                                    
sdyinaspldlsyitprliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe....................................

tqrvfeleHEGEGRMTVTQFHMTAWPDHGVPSEPSdLLYFRQAIRAAFPN-PTSPMLVHCSAGVGRSGTFIAIDHMLQLILdearaaSDVPDVRDVVHGM
        .    . .. |.. . |||||||. .  || | .... |. . |  |.||||||||||.||..|.. ||...|      ... |. |.|. .
........lredlerlgiqylylpwpDhgvpdlsi.llefvkfveealsedpggpvlVHCsaGvgRtGtlvaaylmlrgll......eslvdaldlvrel

RDRRNFMVQTEEQYIFIY
|  |  ||||..||.|.|
RlqrpgmvqtpsQyrfly
subfamily_CG7180_pd Subfamily CG7180 1234-1488 1.2e-42 140.6 In-house 34-288 (296) alignment 
Range on Protein: 1234-1488
Range on HMM: 34-288/296.0
CA---TQANRDKNRYRNITAYDHSRVVLQVNPEEGGCDYYNANYIAGARSPSDYIACQGPTNSSVDDFWRMVWQQKTQCIVMVTNLEEQGRmKCLKYWPD
||    . ||.|||. ..  ||. ||||.    |   || || |. .   . .||  ..|....||.|||.|........|..|.  .. . ....||| 
CagglrkenreknrdvkvvPyDynRvvLekldGeeksdYinavyvdsflkkkeyivteapkketvdefWrlvydeeisavvvLtktfdfak.mypsywpn

LApGVSADDLRADELPKLQLGPyVVFFKERHEHKLWTQRVFELEHEGEGRmTVTQFHMTAWPD-HGVPSEPSDLLYFRQAIRAAFPNP-----TSPMLVH
 .      ..  . . . |.   ..  . .  .|. .    | . . | | .|..|..| |.  . ||.  . |...|. .|    .      ..|..|.
ks.keqygeifveiveekqyan.lkirtfkltkkivalteqekqvkaetR.ivklfqlteWeledkvPlstnalielrrrvrlwrekvdedpeegPvvvv

CSAGVGRSGTFIAIDHMLQLILDEARAasdvpDVRDVVHGMRDRRNFMVQTEEQYIFIYFALEM
.| |..||| ..|||  |.|.  | .      || . |  .|  |. .|.. |.| .||  |. 
ssdGasRsGvylaidanlelvekeeev.....dvFeavktlrrsRpqLvenveeYkyiYdvlle
0043147 (Phosphotyrosine protein) phosphatases II 1265-1483 1.5e-42 140.5 In-house 3-154 (172) alignment 
Range on Protein: 1265-1483
Range on HMM: 3-154/172.0
GGCDYYNANYIAGARSPSDYIACQGPTNSSVDDFWRMVWQQKTQCIVMVTNLeeqgrmkclkywpdlapgvsaddlradelpklqlgpyvvffkerhehk
.|.||.||.|. . . | ..||.|||... ..|||||..... ..||..|.|                                                
egsdyinasyldlyyipdrfiatqgplrntladfwrmlkelgithivnltel................................................

lwtqrvfeLEHEGEGRMTVTQFHMTAWPDHGVPsEPSDLLYFRQAIRA-AFPNPTSPMLVHCSAGVGRSGTFIAIDHMLqlilD-EaraasdvpDVRDVV
        |        .. |.. . |||||||  .. || | . |.  .  .|  |.||||||||||.||..|.. ||               .. ..|
........lydpellerlgiqylylpwpDhgvp.llellleflefidellalspggpvlVHCsaGvgRtgtlvaaylml....lgl........sleeav

HGMRDRRNFMVQTEEQYIFIY
. .|..|. .||...||.|.|
alvrekRpgavqnpsqyrfly
0049772 (Phosphotyrosine protein) phosphatases II 1234-1489 1.7e-41 138.3 In-house 41-279 (314) alignment 
Range on Protein: 1234-1489
Range on HMM: 41-279/314.0
CATQANRDKNRYRNITAYDhSRVVLQVNPEEGgCDYYNANYIAGArspSDYIACQGPTNSSVDDF----------WRMV--WQQKTQCIVM---------
.   .||||||| .|  .| .||.|.  | .| .||.||.|. |     ..||.|||..  |.||          ||||  .....  |||         
adlflnrdknryldilpad.nrvilpglpvsg.sdyinasyvdgf...lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivmsrdevlade

------------VTNLEEQGRMKCLKYWPDLApgvsaddlradelpklqlgpyvvffkerheH-----KLWtqrvfelehegegRMTVTQFHMTAWPDHG
             ..| ..| . . .....|                                     .|.               .. ... . .||..
lsrLdaAlgKtpllildgngneptaadlellk..............................eelydpelf.............erlgikylripvpDgs

VPsEPSDLLYFRQAIRAAfpNPTSPMLVHCSAGVGRSGTFIAIDHMLQLIldearaasDVpDVRDVVHGMRDRRN-----FMVQTEEQYIFIYFALEMA
.|  ..|.. | ..|..|  .. .| ||||.||.||.|||.... .. |         .| ....... .| .|       .... |||.||. ||...
ap.lledfdeflefieea..dkggpvlvHCkaGkgRtgtfvvaaylmkll........gv.sleealedvrlkRpinpnpgfieqleqyefilealley
0046846 (Phosphotyrosine protein) phosphatases II 1258-1486 1.7e-41 137.2 In-house 3-169 (176) alignment 
Range on Protein: 1258-1486
Range on HMM: 3-169/176.0
LQVNPEEGGCDYYNANYIAGARspsdYIACQGPTNSSVDDFWRMVWQQKTQCIVMVTNLEEQGRMKCLKYWPDLAP-GVsaddlradelpklqlgpyvvf
|..  .....|| |||.|.|.|    .||.|||..... ||..|..... ...|..|.. | || ||  |||.|   |.                     
lrllgldldldyinanlilgsr....piatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgi.....................

fkerhehklwtqrvfelehegegrmtvtQFHMTAWPDHGVPSEpSDLLYFRQAIRAAFPNPtSPMLVHCSAGVGRSGTFIAIDHMLQlildearaaSDVP
                            |.. . |||||||.  ..|| . ..|| |  .   | |||||||.||.||..|.. .           .   
............................qylhlpwpDhgvpdl.elllellefirealkeg.gpvlVHCsaGigRtgtlvaayllel.........ekgl

DVRDVVHGMRDRRN-FMVQTEEQYIFIYFAL
.| .... .|..|  ..|||.||| |.| ..
sveealalvreqRplgavqtpeQyrflyefe
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 1202-1486 2.9e-41 136.2 In-house 8-283 (305) alignment 
Range on Protein: 1202-1486
Range on HMM: 8-283/305.0
AILQHLQSKLDA-EGGLQTEFSRLQSVGLRHK--SCATQANRDKNRYRNITAYDHSRVVLQVNpeeGGCDYYNANYIAGARSPSDYIACQGPTNSSVDDF
 ||. ... |.    ||..||. .. .   .|  .     ...||||...   |. || |.        .|  |||..    |  .| .| | . .  ||
qilkfvkrtlekgpaglraefvamkrfndfekmkafkeaqeagknrykdvgcldnnrvklegp...wpheyihanyvstptnpkrfictqaplektcadf

WRMVWQQKTQCIVMVTNLEEQGRMKCLKYWPDLAPGVSADDLRADELP-KLQlGPYVVFFKERHEHKLwTQRVFELEHEGEGRMTVTQFHMTAWPDHGVP
| | .|.| . | |. || |.|  |||.|..     |   . . . .  |..     . |..  . |. |. |. .|  ||    ||..|   ||| |||
wymclqdkveaifmlcnllekgakkcleyfaskdkdvlefeekgqkisvkfe.ssvtlkfrkdakakv.tetvlviegpgekarkvthyhwidwpdrgvp

SEPSDLLYFRQAIRAAfpnpTSPMLVHCSAGVGRSGTFIaidhMLQLILDEARAASDVPDVRDVVHGMRDRRNFMVQTEEQYIFIYFAL
.    .| . .  |..      |. ||||||.||.|. .    ||. |||.  |   . |   ..  .|..||  .||..||.|..  .
aadlailellekarps....kgpivvhcsagigrtgsvv....mleyildqllagqiiedtdkilqkireqrnnsiqtdaqylfvhqvi
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 1236-1484 4.7e-41 135.4 In-house 52-283 (305) alignment 
Range on Protein: 1236-1484
Range on HMM: 52-283/305.0
TQANRDKNRYRNITAYDHSRVVLQvNPEegGCDYYNANYIAGARSPSD-YIACQGPTNSSVDDFWRMVWQQKTQCIVMVTNLEEQGRMKCLKYWPdLAPG
.. .  ||||... . |.| | |. .|    .||  |||.     |   .|..||| . ..|.|| || |.| . |||. .  | |..|| .||| .| |
adiaitknryqdvpcqdqsavkld.kps..psdyihanyvgcpmipekrficaqgpldqtidefwwmviqnkveqivmlcktvelgklkcaqywp.aaqg

VSaDDLRADELPKLQLGpyvvfFKERHEHKLWTQRVFELEHEGEGRMTVTQFHMTAWPDHGVPSEPSDLLYFRQAIRAAfpnpTSPMLVHCSAGVGRSGT
    .|..  . .   |      |  .        ...| . |. .|.| ... | ||| |||      | .  ||| .      |..||||||.||.||
ek.lelksgivvenvsg.....skpmerdaeiqitllnltysgdqkmsvrhlqwtewpdrgvppckltslellsairgs....kvpivvhcsagigrtgt

FIAIDHMLQLILDEaraaSDVPDVRDVVHGMRDRRNFMVQTEEQYIFIYF
 .||...|. | ..     ..| . ..|. .||.| | .|.. ||.||. 
ivaieyilekiaen....kpcppmpelvkalrdqrafsiqndvqylfihr
subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 1237-1488 2.3e-40 133.0 In-house 35-268 (281) alignment 
Range on Protein: 1237-1488
Range on HMM: 35-268/281.0
QANRDKNRYRNITAYDHSRVVLQV-NPEEGGCDYYNANYIAGARSPSDYIACQGPTNSSVDDFWRMVWQQKTQCIVMVTNLEEQGRMKCLKYWPDLAPGV
  |  |||| || . | ||| |.|  |..   ||  ||||        ||  ||| . .  |||||.||..| .|||. .. |  | || .|.|  |  .
pvnnkknrylnipcldisrvqlkvkmpnknstdyihanyirspflkrgyiltqgpkketradfwrmiwqenttaivmlcqfletnrekcaeyfprnahcc

saddlradelpkLQLGPYVVFFKERHE-HKLWTQRvFELEHEGEGRMtVTQFHMTAWPDHGVPSEPSDLLYFRQAIRAAfpnpTSPMLVHCSAGVGRSGT
            ||.  . | ...    . | | | ..| .||| |. .|..    |||  ||     .|   . |||     ..| ..|||||||||||
............lqfdklsvsyedstvnkslvttr.lnlsyegetrl.ithwlwkewpdwqvpessevmlkilrkirar....stppvihcsagvgrsgt

FIAIDHMLQLIldeaRAASDVPDVRDVVHGMR-DRRNFMVQTEEQYIFIYFAL-EM
..|..  || |    ..   .||....|  .|   |   ||| .||..|.  | ..
lmaveialqsi....hshftlpdikqivshlrvtgraasvqtlqqymliwkvlldf
0049260 (Phosphotyrosine protein) phosphatases II 1275-1483 6.6e-40 131.6 In-house 2-143 (152) alignment 
Range on Protein: 1275-1483
Range on HMM: 2-143/152.0
IAGARSPSDYIACQGPTNSSVDDFWRMVWQQKTQCIVMVTNLEEQGRMKCLKYWpdlapgvsaddlradelpklqlgpyvvffkerhehklwtqrvfele
| | . |  .||.|||.. ...|||||..... ..|||.|.|.| |. || .|.                                              
idgyampfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi..............................................

hegegrmtvtQFHMTAWPDHGVPSEPSDLLYFRQAIRAAFPNPTSPMLVHCSAGVGRSGTFIAIDHMLqlildearaasDVPDVRDVVHGMRDRRNFMVQ
          |.. . |||||||. .  || . ..|. .  ..  | ||||||||||.||..|.. ||              .. ..|  .| .|. .|.
..........qylhlpwpDhgvpdlsqlllflllfieklaldkggpvlVHCsaGvgRtgtlvaaylml...........lgvsleeavalvrekRpgavp

TEEQYIFIY
...|..|.|
npgqlrfly
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 1239-1482 9.5e-38 124.5 In-house 56-275 (290) alignment 
Range on Protein: 1239-1482
Range on HMM: 56-275/290.0
NRDKNRYRNITAYDHSRVVLQvnpEEGGCDYYNANYIAGARSPsdYIACQGPTNSSVDDFWRMVWQQKTQCIVMVTNLEEQGRMKCLKYWPDLAPGVsad
.  ||||....  | .||.|.   . .  ||  |||. | ...  .|  ||.....| |.|||| |.|.  |||. .| |.|. || .|.|. .  |   
efkknrykdvvcndktrvilk...dGydGdyvhanyvkGlkam..filtqGalkdtvidiwrmvlqekvaaivmlceliedGkakceqyypekeGev...

dlradelpkLQLGPYVVFFKERHEHKL-WTQRVFELEHEGEGRM-TVTQFHMTAWPDHGVPSEPSDLLYFRQAIRAAfpnpTSPMLVHCSAGVGRSGTFI
         | .| . |   | ...     .... . .  .|.   .  ... .|||. |.     ||   ...| |    . |. ||||||.||.|||.
.........ltfGeitvlcseeddkdaniikktlsvrdkdsGkehklkhlkikswpdksvalstlallrtlrilrka....sGpvvvhcsaGiGrtGtfv

AIDHMLQLILDEArAAsdvpDVRDVVHGMRDRRNFMVQTEEQYIFI
||.  ||..||   .     |. |.|  .|. |   || . ||. .
aievglqilldGk.el....dlldlvralrnsrlnsvqvdiqylal
subfamily_ptpA1_pd Subfamily ptpA1 1200-1443 1.2e-37 124.6 In-house 6-254 (418) alignment 
Range on Protein: 1200-1443
Range on HMM: 6-254/418.0
VDAILQHLQSKLDAEGGLQTEFSRL-QSVGLRHKSCA-TQANRDKNRYRNITAYDHSRVVLQVNPEEGGCDYYNANYIAGARsPSDYIACQGPTNSSVDD
. . .  |. .. .   .. ||  | .|||    |    . |  |||| ||   .|.|| |.   .. | || ||||| ||  | ..|. |||   .. |
ikssiynlknhikcihkikeefrlleesvgpsetsegdkkhntsknrytnilpvnhtrvqlkkiqdkegsdyinanyidgay.pkqfictqgplpntiad

FWRMVWQQKTQCIVMVTNLEEQGRMKCLKYWPDLAPGvsaDDLRADELPKLQLGPYVVFFKE---RHEHKLWTqRVFELEHEGEGRmTVTQFHMTAWPDH
||||||... . |||..   |. |.|| .|||.   |   ...      .  .| | | . |     |... | |   |  ||| |  .||..   ||||
fwrmvwenrcriivmlsresencrikcdrywpeqigg...eqfsiygngnevfgtysvelveviqdpereiit.rnirltfegetr.ditqyqyegwpdh

GVPSEPSD--LLYF----RQAIRAAFPNPTSPMLVHCSAGVGRSGTFIAIDHMLQ
 .|        | .    ||       .   |..|||||||||.||| .   |..
nipdhtqpfrqllhsitnrqnqiipssdrnvpiivhcsagvgrtgtfctavimmk
0044763 (Phosphotyrosine protein) phosphatases II 1251-1486 4e-36 119.7 In-house 2-167 (178) alignment 
Range on Protein: 1251-1486
Range on HMM: 2-167/178.0
YDHSRVVLQVNPEEGGCDYYNANYIAgarsPSDYIACQGPtnssvDDFWRMVWQQKTQCIVMVTNLEEQGRMKCLKYWPDLAPgvsaddlradelpklql
.|..||.|.  . . ..||.||..|     |  |.....|      |......... ..||..|.  | |..||..|||. |                  
ldrtrvllsnleglersdyinaseil....pglylgslpp.....addlellkelgithivnlteelelgflkcdpywpeeag.................

gpyvvffkerhehklwtqrvfelehegegrmtvTQFHMTAWPDHGVPSEPSDLLYFRQAIRAAFPNPTSPMLVHCSAGVGRSGTFIAIDHMLQLildear
                                  |.. . .||||||. .. .| | ..|..| ... .| |||||||||||||..|.. |..|      
.................................iqylhipipDhgvpdllehflefvefieealdekggpvlVHCsaGvgRsgtlvaaylmkkl......

aasDVpDVRDVVHGMRDRRNfMVQTEEQYIFIYFAL
   .. .. .... .| ||. .|....|. ..|   
...gl.sleeaielvrerRp.ivpnpgqlrqLyefe
0051082 (Phosphotyrosine protein) phosphatases II 1268-1486 1.8e-34 113.8 In-house 4-149 (151) alignment 
Range on Protein: 1268-1486
Range on HMM: 4-149/151.0
DYYNANYIAGArspsdYIACQGPTNssvdDFWRMVWQQKTQCIVMVTNLEEQGrmKCLKYWPDLApgvsaddlradelpklqlgpyvvffkerhehklwt
||.|..|. |      .....||..    ||........ ..||.....|| |  .| .|.|.|                                    
dyinfsyvtgg.....lyrsggpla....dflellkelgiktivnlrseeerg..ycpeylpelg...................................

qrvfelehegegrMTVTQFHMTAWPDHGVPSEPSDLLYFRQAIRAafpNPTSPMLVHCSAGVGRSGTFIAIDHMLQLildearaasdvPDVRDVVHGMRD
             ..|...... |||.|.|  .  .| | .....   ..  |.|||||||.||.||..|.. ||.             .. .... .| 
.............ievlhipildwpdpglplsfdavleflellld...kkngpvlvHCsaGkgRTGtlvalylmllg...........vsleealeeyrl

RRNFMVQTEEQYIFIYFAL
.|  .||...|..|..|||
krpgvvqpnqqflfqlfal
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 1239-1408 5.2e-34 112.5 In-house 33-191 (297) alignment 
Range on Protein: 1239-1408
Range on HMM: 33-191/297.0
NRDKNRYRNITAYDHSRVVLQVNPEEggCDYYNANYIAGARSPS--DYIACQGPTNSSVDDFWRMVWQQKTQCIVMVTNLEEQGRMKCLKYWPDlapgVS
   |||||.| |.| .|| |.  . |   || ||.|..    ..   ||  |||....|||||..|..|  . ||||..|.|.|| ||  |||.    | 
slrknryrdilatddtrvkllrvite..rdyinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmvaklqedGrdkcapywps....vv

ADDLRADELpklqLGPYVVFFKERHEHKLWTQrvFELEHEgEGRMTVTQFHMTAWPDHGVPSEPSDLLYFRQ
 . |.| ..    .  ..  . . ...   |.  ..| .  . .  |.     .||||||||.  ||  |. 
qerlkagdv....vveflsstsdefdrvilte..lqliyr.sesrvvrhvqflswpdhGvpsdledlvrfqa
PTPc_DSPc_SM00012 1382-1485 2.3e-32 106.7 In-house 1-102 (105) alignment 
Range on Protein: 1382-1485
Range on HMM: 1-102/105.0
TVTQFHMTAWPDHGVPSEPSDLLYFRQAIRAAFPNP--TSPMLVHCSAGVGRSGTFIAIDHMLQLILDEAraasDVPDVRDVVHGMRDRRNFMVQTEEQY
||...|.|.|||||||.|....| . .|..    .   ..|..|||||||||.|||.|.| .|| . .|     . .|. ..|. .|..|. ||||||||
tvkhyhytgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleket....kevdifqivkelrkqRpgmvqteeqy

IFIYFA
.|.| |
lflyra
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 1238-1490 3.2e-31 103.4 In-house 42-271 (288) alignment 
Range on Protein: 1238-1490
Range on HMM: 42-271/288.0
ANRDKNRYRNITAYDHSRVVLQvnpeeGGCDYYNA-NYIAGARSPSDYIACQGPTNSSVDDFWRMVWQQKTQCIVMVTNLEEQGRMKCLKYWPDlAPGVS
||  ..||.|.   | .|| |.       .|.| | | .. |. .   | .| | |. .. .|.|. ..  . |||...| |.|. |  .|.|    | .
anptrdryenlprcditrvkls.....ddpdfyiaanvvssakykrrlicaqaPlngtieelWkmllesdveyivmlcellekGkeksaeyfPs.klGek

ADDLRAdelpklqlgPYVVFFKERHEHKLWTQRVFELEHEGEGRMTVTQFHMTAWPDHGVPSEPSDllYFRqaIRAAFPNPTSPMLVHCSAGVGRSGTFI
|   |            ||  |    .|| .  ..  ..||| .. | . |.  |.|.||| .     ..|  .   . . . |..||.||||||.||.|
arigrl.........ctvvkkkradidklvkvsllriskegeekvivkilhlleWdddgvPenyls..plr..llevlkslqkPivvhssaGvGrtgtli

aidhmLQLILDEARAASDVPDVRDVVHGMRDRRNFMVQTEEQYIFIYFALEMAL
     | ||  |.   .|   .| ... .|. |   .||| ||....  .   |
.....lilialeslrlddflgirsllaklreerfkaiqtemqylyvhrcvleel
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 1212-1486 2.5e-28 93.8 In-house 3-255 (267) alignment 
Range on Protein: 1212-1486
Range on HMM: 3-255/267.0
DAEGGLQTEFSRLQSVGLRHKSCAT---QANRDKNRYRNITAYDHSRVVLQVNPEEggcdYYNANYIAGARSPSDYIACQGPTNSSVDDFWRMVWQQKTQ
| |  .. ||  .. .   .  ...   . |...||. .   ||..||.|. . ||    | || |. | .    .|. |.| . .. ||. .. .||  
deeceiekefelikkisdtsstisqsiaeknqernrlddnlpyddtrvilrtkeee....yinasyvegyktknafivtqdplkntitdfltvihdqkvp

CIVMVTNLEEQgrmKCLKYWP-DLAPGVSADDLRADElpklqlgpyvVFFKERHEHKLWTqrvFELEHEGEGRMTVTQFHMTAWPDhGVPSEPSDLLYFR
 ||..|.  ..   .  ..||  ..     .||  .            . ||  .... |   .||. . |    || ..   |    .  .|     | 
vivlltkvftd...nirlfwPPkmgqakkyqdltveh..........slekeendyqiit...lelkfknesahnvtlyyykkwni.ntnnkpylkplfg

QAIRAAFPNPTSPMLVHCSAGVGRSGTFIAIDHMLQLILDEaraasDVPDVRDVVHGMRDRRNFMVQTEEQYIFIYFAL
   .  . |   |..|.||.||||||||. || .|. .  |     .| |. | .  .|..|  .|.| |.||.|.  |
ilaknqlengnrPlvvacsdGvGrsGtflvidsqlerakte.....gvsdifdflrkirsqriglvdtkeryiyihell
subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 1234-1486 1.3e-26 88.3 In-house 30-266 (285) alignment 
Range on Protein: 1234-1486
Range on HMM: 30-266/285.0
CATQANRDKNRYRNITAYDHSRVVLQVNpeegGCDYYNANYIA-GARSPSDYIACQGPTNSSVDDFWRMVWQQKTQCIVMVTNLEEQGRMKCLKYWPDLA
 | .|| | ||| .. . . .||||.        ||  |...    .  | ||. |||   .. |||.|..|.|   ..|.  | | |  ||  |.|.  
tayeanpdlnryadvrcieetrvvlknh....drdyihaswmrmpgkdqstyittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekcalyypekl

PGVsaddlradelpkLQLGPYVVFFKERHEHK----LW-TQRVFELEHEGEGRMTVTQFHMTAWPDHGVPSEPSDLLYFRQAIRAAFPNpTSPMLVHCSA
  |            ...| | . . | .|      .. .  | . |      . . . ..  |||.  | .   .. . . ..   |.   |. |||||
gev............vkfgkyeitlteckeeaiagtilnaltvintedasseplymnhvqvpwwpdqlapedarpmielykwvkkvnpk.ekpicvhcsa

GVGRSGTFIAIDHMLQLILDEARAasdvpDVRDVVHGMRDRRNFMVQTEEQYIFIYFAL
||||. ||. ||.    |...        .. |.|. ||  |   ||.  |..|.|  |
gvgrtatfvgidyatirimenpni.....emldivremramrfqavqshmqflflyvvl
subfamily_CG42327_pd Subfamily CG42327 1238-1405 1.6e-25 84.4 In-house 27-185 (319) alignment 
Range on Protein: 1238-1405
Range on HMM: 27-185/319.0
ANRDKNRYRNITAYDHSRVVLQVNPEEGGCDYYNANYIAGAR-SPSDYIACQGPTNSSVDDFWRMVWQQKTQCIVMVTNLEEQGRMKCLKYWPDLAPGVS
. .||.|. |.    ..|||||  ...    | .|.|. | . .|. |||.| . ..|  ||||.||.|... || .|.| |.|  .| .|.|  . . .
tskdksrvinvvPlPetrvvlqrigdddkdeyldasyvrGyddapnsyiaaqvsledsssdfwrtvweqqsrvivqltdlselGikvcaeylPtketldn

AdDlradelpklQLGPYVVFFKERHEHKLWTQRVFE-LEHEGEGRMTVTQFHMtAWPDHGVPSEPSDLLY
  .           | . | .|.|  .. .    .   . ..|    .| .    |.. .||.|.. |. 
t.s.........lyGdilvtlkgrevkdryaistlllkrvdkeesrelthywy.kwleaevPaeeaalia
subfamily_egg_pd Subfamily egg 1233-1487 2e-25 84.1 In-house 34-267 (307) alignment 
Range on Protein: 1233-1487
Range on HMM: 34-267/307.0
SCATQANRDKNRYRNITAYDHSRVVLQVNPEEGGCDYYNANYIAGARSPSDYIACQGPTNSSVDDFWRMVWQQKTQCIVMVTNLEEQgrMKCLKYWPDla
 .|.. |..| | . .   | ||| |...      |.  ||.. |     ..| .| |   .||||||||.|.. | |||.|   |    .|  |||   
taasdnnlekarskrvhckdssrvklelrrGqylddfihanrvkGkpllnefilaqaplkntvddfwrmvfqeevqyivmltsrkes..erceyywpk..

pgVSADDLRADeLPKLQLGPYVVFFKERHEHKLWTQRVFELEhegegrmtVTQFHMTAWPDHgvPSEPSDLLYFRQAIRaAFPNPTSPMLVHCSAGVGRS
    .| |.      |..  . |  |     ..   ..   .          . ..  |       . ||. .  . .|    | . |..|..  || ..
..aesdslvtv.pGslrienlkvdskadplfrvtklklvGgd........deerflehwqgd..vnnssdvysplrvlr.klrnlskpvvvqdilGvska

GTFIAIDHMLQLILDEaraASDVPDVRDVVHGMRDRRNFMVQTEEQYIFIYFALE
.|..||.  |  .|           |.  |  .| ||.. |..  .|.|.|  . 
atlvaieiallsllrG...pitkslvlravvflrlrrrlsvesvllylfvyrlvl
0048076 (Phosphotyrosine protein) phosphatases II 1345-1486 2.7e-25 84.1 In-house 8-139 (145) alignment 
Range on Protein: 1345-1486
Range on HMM: 8-139/145.0
LPKLQLGPYVVFFKERHEHKLWTQRVFELEHEGEGR-MTVTQFHMTAWPDHGVPSEPSDLLYFRQAIRAAFPNPtSPMLVHCSAGVGRSGTFIAIDHMLQ
||.| ||.. .  . .. ..|   .|. | .| |.   ...|.. . |||||||. ...|| | ..|..| ...  |.||||||||||.||..|.. ||.
lpglylgslptaldlellkdlgittvlnltselellerlgiqylylpwpDhgvpdllellleflefieealkeg.gpvlVHCsaGvgRtgtlvaaylmll

lildearaaSDvPDVRDVVHGMRDRRNFMVQTEEQYIFIYFAL
          .  .. .... .| .| ..|....|..|.| ..
.........lg.vsleealelvrsqrpgavpnpgqlrflyefe
subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 1237-1485 8.9e-25 82.0 In-house 41-271 (312) alignment 
Range on Protein: 1237-1485
Range on HMM: 41-271/312.0
QANRDKNRYRNITAYDHSRVVLQVNpeEggCDYYNANYIAGARSPSDYIACQGPTNSSVDDFWRMVWQQKTQCIVMVTNLEEQGRMKCLKYWPDLAPGVS
   .| ||| ||  .|  |  |  .  |    |  ||..     |  ....||| ....  ||...    . .|.... . |.|  || ||  |.   | 
lkfkdlnrypniqcwdrgrftlagd..e..nfyihanfvkictkperfvctqgplentcthfwqlalslgstsiillcgfvedgsekcakyisdivgfvd

ADDLRA--DELPKLQLGPYVvffKERHehklwTQRVFELEHEGEGRM-TVTQFHMTAWPDHGVPSEPSDLLYFRqairAAFPNPTSPMLVHCSAGVGRSG
 .| |   .   ....|      |..      |.||. .     |.   . ..  ..|||||.|      | .     .|  .   |.. ||||||||.|
ledhrvyteycteieiggks...kdki.....thrvlkvvvkatgqesklnhyqwaswpdhgmpdscdtalrll....savkkdkkpviahcsagvgrtg

TFIAIDHMLQLiLDEARAAsdvpDVRDVVHGMRDRRNFMVQTEEQYIFIYFA
|.. |. |.   |   |      .|.|.   .|  |   |..  ||..   .
tlaliesmiaa.lrhprkq....nvkdsfvllrkdrarsvrvfpqyvyalrc
subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 1238-1482 4.7e-24 79.7 In-house 49-273 (301) alignment 
Range on Protein: 1238-1482
Range on HMM: 49-273/301.0
ANRDKNRYRNITAYDHSRVVLQVNpeeGGCDYYNANYIAGARSPSDYIACQGPTNSSVDDFWRMVWQQKTQCIVMVTNLEEQGRMKCLKYWPDLAPgvsa
 ..||.|| ..    .. | . |.   |      ||.|     |  .|| ||| ... .||| |. | . . |||...  |.   || .| |   .    
lpkdkhryptvPckPstavevivd...GkrvPihanwiptsGhphrfiatqgPlkntsedfwamlvqydvekivmlgqkvekleekceeylpvkis....

ddlradelPKLQLGPYVVFFKERHE--HKLWTQRVFELEHEGE--GRMTVTQFHMTAWPDHGVPSEPSDLLYFRQAIRAAfpnpTSPMLVHCSAGVGRSG
         ||..| . .  |...   .|  ..| .|.|   .     ||| .  . |.|.|||    .|  . . .. .      |..||||||.||| 
........ekldigrfkikiknkelilnkkiskrtlevedstgkfatrtvthyqysewtdrgvPkshaelfdlmelvkks....ekPivvhcsaGiGrsv

TFIAIDHMLQLILDEARAasdvpDVRDVVHGMRDRRNFMVQTEEQYIFI
.||. . . . .. . .      .. . .. .|..|   |||..|  ..
afigteylareveadpti.....eltealkhlrehrwngvqtnsqlywm
0048179 (Phosphotyrosine protein) phosphatases II 1372-1484 4.8e-24 80.1 In-house 39-139 (144) alignment 
Range on Protein: 1372-1484
Range on HMM: 39-139/144.0
ELEHEGEGRMtVTQFHMTAWPDHGVPSEPSDLLYFRQAIRAAFPNPtSPMLVHCSAGVGRSGTFIAIDHMLqlildearaASDvPDVRDVVHGMRDRRNF
| |.| ..|. ..|.. . |||||||. ...|| | ..|..| ...  |.||||||||||.||..|.. |.           .  .. .... .| || .
eyepeflere.giqylhlpwpDhgvpdllellleflefieealeeg.gpvlVHCsaGvgRtgtlvaaylmk.........klg.lsleealalvrsrrpg

MVQTEEQYIFIYF
.|....|..|.. 
avpnpgqlrfLle
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 1241-1331 7.9e-23 75.7 In-house 49-153 (350) alignment 
Range on Protein: 1241-1331
Range on HMM: 49-153/350.0
DKNRYRNITAYDHSRVVLQ--------VNPEEGGCDYYNANYIAGA----RSPSD--YIACQGPTNSSVDDFWRMVWQQKTQCIVMVTNLEEQGRMKCLK
 ||||.||  |.|||| |.        ..    . || ||||.  .    .  .|  ||| |.|. | ||||.... . | . |...|.. |... || .
aknrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvkvilsltsdvelnlekcyr

YWPDL
||...
YWqeg
subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 1289-1490 5.6e-22 72.5 In-house 98-288 (302) alignment 
Range on Protein: 1289-1490
Range on HMM: 98-288/302.0
GPTNSSVDDFWRMVWQQKTQCIVMVTNLEEQGRMKCLKYWPDLAPGVSadDLRADELPKLQLGPYVVFFKERHEHKLWTQRVFELEHEGEGRMTVTQFHM
 | .|... .| .. | ..  .| .... |..  || .|. |   |.    ..   .  ...   .  | .... ||.|  . . ... . ..||  .. 
vpkkstlekhwalieqynvaivvqlcsfvedeekkcaeyysdkvggel..kfgrytvktvsvktdleeftdkksfklytveiknekkkkkvkktvdilaf

TAWPDHGVPSEPSDLLYFRQAIRAaFpnpTSPMLVHCSAGVGRSGTFIAIDHMLQLILDEaraasDVPDVRDVVHGMRDRRNFMVQTEEQYIFIYFALEM
.|||||| | |.   |   .   . .      .||||||||||.||..|| . .|| . .     .| |. ..|  .|. |   ||.|.| |.. . .  
sawpdhGapkeaytaldilkfces.y...kknvlvhcsaGvGrtGtlvaikyGiqlcskk.....kvtdllsivlpvrqcryGavqdeqqliylllcvtk

AL
.|
gl
subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 1236-1332 5.3e-20 66.2 In-house 49-144 (310) alignment 
Range on Protein: 1236-1332
Range on HMM: 49-144/310.0
TQANRDKNRYRNITAYDHSRVVLQVNPEEGGcDYYNANYIAGARSPSDYIACQGPTNSSVDDFWRMVWQQKTQCIVMVTNLEEQGRMKCLKYWPDLA
 . .  |||| ..   | ||| |...    . ||  |||.      | .| .||| . .. |||||..|.... |... .  |.|| ||. ||| | 
ykkymhknrysdvvcldtsrvklkidksrye.dyihanyvktnylrstficsqgplqhtiidfwrmifqeraesilllckvgeegrpkcvgywpslg
subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 1248-1494 1e-18 62.5 In-house 27-263 (290) alignment 
Range on Protein: 1248-1494
Range on HMM: 27-263/290.0
ITAYDHSRVVLQVNPEEGGCDYYNANYIAGArSPSDYIACQGP-------TNSSVDDFWRMVWQQKTQCIVMVTNLEEQGRM----KCLKYWPDlapgvs
..   ..||||..  .    ||  ||..  . .    |. | |        || . .|| |. | | . .||. . ||. .      | || |.      
vpLveatrvvLkgygkrfnddyiHAnrvtcp.nglrliltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCakYvpe......

addlRADElpKLQLGPYVVFFKERHEHKLWTQRVFELEHEGEGRMTVTQFHMTAWPDHGVPSEPSDLLYFRQAIRaafpNPTSPMLVHCSAGVGRSGTFI
    ...|  .|...   |  |.. ...   .|  ......|  .|||   .  | .  |. ..  ||   | ..    . ..|..|||  |. || .. 
....svge..elkfkgltvkCkskekeddvetRelvvkfddeeeftvtHsllkgWnklnvqedtktllsliqkvk....asktpvivHcvdGiSrsAala

AIDHMLQLILDEARAASdvpdVRDVVHGMRDRRNFMVQTEEQYIFIYFALEMALTAMQ
||.   |.| .   . .    ..||.. .| .|. ........ |.  .. . .. ..
aiilgyQkiaetsgsvk....ledvlkalrkqralaitsalelafvdagivllaievl
subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 1294-1493 3.5e-17 57.3 In-house 40-221 (255) alignment 
Range on Protein: 1294-1493
Range on HMM: 40-221/255.0
SVDDFWRMVWQQKTQCIVMVTNLEEQGRMKCLKYWPdlapgvsaddLRADE---LPKLQlgpyVVFFKERHEHKLWTQRVFELEHEGEGRMTVTQFHMTA
.|| |.... |.||. .||.....|.|. || .|.|          |  ||   | ...    |.  |   .  | | ..     |     ||. .. . 
tvdkfyqtivqtktevvvmlcdfaeegvekcssyfp..........lekdeklkladvn....vtttkssadvvlrtleitstlgekkkthtvkhysykG

WPDHGVPSEPSDLLYFRQAIRAAfpnptSPMLVHCSAGVGRSGTFIAIDHMLQLILDEARAASDV-PDVRDVVHGMRDRRNFMVQTEeqyIFIYFALEMA
|...  | .. ..|.  ...| .      ...||||.|.||| .|. .. . | ..   . .. |  | . ... .| .|.  ..|    . . |.. | 
WieknaPelareilnilkvvrds.....ksvvvhCstGiGrsaafvlaelvyqkmirsldttetveldylslleelrskrkraihtP...lqlafsilmv

LTAM
|. .
ldlv
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 1381-1490 7e-17 55.9 In-house 89-194 (440) alignment 
Range on Protein: 1381-1490
Range on HMM: 89-194/440.0
MTVTQFHMTAWPDHGVPSEPSDLLYFRQAIRAAFP-NPTSPMLVHCSAGVGRSGTFIAIDHmlqlILDEARAaSDVPDVRDVVHGMRDRRNFMVQTEEQY
 |. |.|. .|||.|||   . .| . | .  .      .|.|||||||.||.|  ||.|     || ||.  ||  |.  ..  ||. |  |||| |||
rtlkqyhyqgwpdkgvpkfagpvlkmiqdvnesqekagngpllvhcsagagrtgviiavds....ilreakr.sdqidifsfinsmrnnrpqmvqtpeqy

IFIYFALEMAL
 |.. |.  .|
afvheavlegl
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 1384-1487 1.3e-16 55.3 In-house 218-341 (350) alignment 
Range on Protein: 1384-1487
Range on HMM: 218-341/350.0
TQFHMTAWPDHGVPSEPSDLLYFRQ----------AIRAAFPNPTSPMLVHCSAGVGRSGTFIAIDHMLQ--LILDEARA---ASDVP-DVRD----VVH
 |...  |.| ..  .| ..|   .          |      . .||.|||||||||| ||....|..|.  .||.. .     .||.  .||    .| 
yqlqvknWkDlslllnPesilqalevkndliddlfaeshldnarsspilvhCsaGvGrtGtlvtlDsllsdfeilenltkesrkldvaaktrDlisiivn

GMRDRRNFMVQTEEQYIFIYFALE
 .| .|  |||. .|.|||| || 
elrkqrismvqnldqfifiYeall
Guanylate_kin Guanylate kinase 446-520 3.2e-15 43.4 Pfam-A 14-87 (183) alignment 
Range on Protein: 446-520
Range on HMM: 14-87/183.0
GTQASLRSVTQQQPLLFYdASVPLTTRTPEAGEVQGQTYHFVSPQLFHFFLANKHLAEWGQYLDHYYGSLKRSIE
|..     . ...|  |   ||. |||.. .|||.|. |.||| . ..   ..... |.... ...||. . .||
GkstlkkaLldelpekfg.isvshtTrdkrkgevdGkdYfFvskeelekdiskneflEaaefsgnlygtsveeie
subfamily_hpo-7_pd Subfamily hpo-7 1294-1503 2.7e-14 47.7 In-house 46-238 (263) alignment 
Range on Protein: 1294-1503
Range on HMM: 46-238/263.0
SVDDFWRMVWQQKTQCIVMVTNLEEQGRMKCLKYWPdlapgvsaddLRADELPKLQlGPYVVFFKERHEHKLWTQRVFELEHEGEGRMTVTQFHMTAWPD
 .| |.... |.||. .||... .|.|. || .|.|          |  ||  ||.    |.  |  ..  | |. . .   |     ||...  . |..
tidkfyqtivqtktevvvmLcDfneegvekcssyfP..........lekdekqkla.nvnvcttkvqsdvllktlellstlgeKkkthtvkhysykgWie

HGVPSEPSDLLYFRQAIRAAfpnptSPMLVHCSAGVGRSGTFIAIDHMLQLILDEARAASDV-PDVRDVVHGMRDRRNFMVQTEeqyIFIYFALEMALTA
.  | .. . |.  .. |        .. ||||.|.|||  |  .. . | ..   . .| |  | . ... .| .|.  ..|    . . |.. | |. 
kndpelareilnilkvarns.....kslvvhcstGiGrsaafsvaElvyqkmirsldttstveldylsLleelrssrkraihtP...mqLafsilmvLdf

-MQATDKADLKM
 ...  | .|. 
vlnnfakgelea
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 1409-1485 6.6e-14 46.4 In-house 220-290 (297) alignment 
Range on Protein: 1409-1485
Range on HMM: 220-290/297.0
AIRAAFPNPTsPMLVHCSAGVGRSGTFIAIDHMLQLIldeaRAaSDVPDVRDVVHGMRDRRNFMVQTEEQYIFIYFA
..||. | .. ..||||||||||||  .  | .|. .    |    .|||. ... .|..|  .||| ||. ..| |
slraemprna.yllvhcsaGvGrsGvvvlsdvilakl....rk.kripdvaailsilreqrarlvqtleqfellyda
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 1241-1331 1.1e-13 45.2 In-house 50-156 (349) alignment 
Range on Protein: 1241-1331
Range on HMM: 50-156/349.0
DKNRYRNITAYDHSRVVLQVNPEE-----------GGC---DYYNANYIAGARSPSD--YIACQGPTNSSVDDFWRMVWQQKTQCIVMVTNLEEQGRMKC
 ||||..|  |.||||.|.  ..             ..   || ||||.  .|   .  ||| | |  |.||||....  .. . .. ... .|..  ||
aknrykdilPyehsrvklkkslksskvikastsesdsgklddyinanylkltrisvekkyiatqaPlPstvddfykvillngvklvlsLnddkelslekc

LKYWPDL
 .|| .|
diywqel
subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 1238-1486 2.2e-13 44.5 In-house 46-275 (303) alignment 
Range on Protein: 1238-1486
Range on HMM: 46-275/303.0
ANRDKNRYRNITAYDHSRVVLQvnpeegGCDYYNANYIAGArSPSDYIACQGPTNSSVDDFWRMVWQQKTQCIVMVTNLEEQGRMKCLKYWPDlapgvSA
 | ||||. ..   |||.| |          |  |.|.    |    |  | | . .  |||.|. .|| .|....    |  ..     .|        
knmdknrfvdvicldhskvkls......dssyihasyleld.sskkailtqlplshtaadfwqmiieqkvkcvlllltdseydklggdsvfpr.....nq

DDLRADElPKLQLGPyvvfFKERHEHKLWTQRVFELEhEGEGRMTVTQFHMTAWPDHGVPSEPSD----LLYFRQAIRAAFPnPTSPMLVHCSAGVGRSG
| |. .|   ...|     ||.    . |. .|  .  .|. .  .   |  |||   .||. |      ..  |..   .  ...| .    .|.||.|
dflkfee.rsirvge....fkrvelgdgwvlkvlsvs.ngdyksflhvhhykawphnsipsdgspkfvkqiwqlqsvlrkys.dstptvymslsgcgrag

TFIAIDhMLQLILDEARAASDVPDvrdVVHGMRDRRNFMVQTEEQYIFIYFAL
||  ..   .| | . .|. |.     ..  .|. |   ||   |. ..|  |
tfalfe.tahlslhseqasldlvk...clenvrngrlhavqnlsqfsvvytll
Ank_2 Ankyrin repeats (3 copies) 144-213 3e-13 38.0 Pfam-A 15-80 (89) alignment 
Range on Protein: 144-213
Range on HMM: 15-80/89.0
ILLRAKADGDCqdvmGNSALHTAAHFGHVDVVHLLLQYQVDCHRLNNQAENALFTAVRQNQAACVRLFVK
.|| ..|| |     |...|| ||  |....| |||... |.   ... ..||. |||.... .|.| ..
lLlekgadvdl....getpLhlAaeagnleivklLleagadvnakdkegntaLhlAvrnghlelvklLle
subfamily_CG42327_pd Subfamily CG42327 1417-1488 7.4e-13 42.8 In-house 246-313 (319) alignment 
Range on Protein: 1417-1488
Range on HMM: 246-313/319.0
PTSPMLVHCSAGVGRSGTFIAIDHMLQLiLDEARAASDVPDvrdVVHGMRDRRNFMVQTEEQYIFIYFALEM
   |. |||| ||||.|. || |  ..  |.|.. . |.|.   .|. .|  |   |.| ||| |||  | .
sqGPlvvhcsdGvGrtGlviasdiairs.leeskrsvdiPq...lvssvrrdrasavltkeqyefiykvlse
Ank_4 Ankyrin repeats (many copies) 159-211 1.5e-12 35.8 Pfam-A 1-53 (54) alignment 
Range on Protein: 159-211
Range on HMM: 1-53/54.0
GNSALHTAAHFGHVDVVHLLLQYQVDCHRLNNQAENALFTAVRQNQAACVRLF
|..||| ||..|....|.|||.. .|..|.... ..||  |.. ..  ...|.
gltaLhyaaisgrlelvklLlekgidinrtdesGntaLhiAalrgnieilklL
subfamily_Cele-PTP-12_pd Subfamily Cele-PTP-12 1238-1323 3.2e-12 40.6 In-house 33-117 (332) alignment 
Range on Protein: 1238-1323
Range on HMM: 33-117/332.0
ANRDKNRYRNITAYDHSRVVLqvNPEEGGCDYYNANYIAGARSPSDYIACQGPTNSSVDD-FWRMVWQQKTQCIVMVTNLEEQGRMK
 | | ||   . ..||||| |   |..|  |.|||... |    | || .| | |   .  ||||| ..|   |... ...|. . |
nnmdmnriphlycfdhsrvel..apqdgkddfynaswvdgyskksayifaqapfndhteyvfwrmvserkpsmilvfgdidekqkrk
subfamily_Sponge-PTP-7_pd Subfamily Sponge-PTP-7 1421-1490 1.3e-11 38.8 In-house 1-65 (69) alignment 
Range on Protein: 1421-1490
Range on HMM: 1-65/69.0
MLVHCSAGVGRSGTFIAIdhmlqlILDEARAASD-VPDVRDVVHGMRDRRNFMVQTEEQYIFIYFALEMAL
|.||||.| ||.||||||      ... ||  |. . |. . |  ||  |  ||  | .||||. ||  ||
mvvhcssgtgrtgtfiai......mvemarikseklvdifnnvqymrkcrpmmvmneieyifihdalveal
Ank_5 Ankyrin repeats (many copies) 146-199 3.4e-11 31.2 Pfam-A 2-56 (56) alignment 
Range on Protein: 146-199
Range on HMM: 2-56/56.0
LRAK-ADGDCQDVMGNSALHTAAHFGHVDVVHLLLQYQVDCHRLNNQAENALFTA
|..  || ...|  ||..||.||. |...|| |||....|..  ... ..||  |
lehgpadvnatdeggntpLhlAakggalevvrlLlapgadlnlrdsdgltaldlA
subfamily_Sponge-PTP7_pd Subfamily Sponge-PTP7 1423-1490 7.1e-11 36.3 In-house 2-64 (69) alignment 
Range on Protein: 1423-1490
Range on HMM: 2-64/69.0
VHCSAGVGRSGTFIAIdhmlqlILDEARAASD-VPDVRDVVHGMRDRRNFMVQTEEQYIFIYFALEMAL
||||.| ||.||||||      ... ||  |. . |. . |  ||  |  ||  |..|.||. ||  ||
vhcssGtGrtGtfiai......mvemarikseklvdifnnvqymrkcrpmmvmneneymfihdalveal
PDZ PDZ domain (Also known as DHR or GLGF) 542-616 9.6e-10 28.7 Pfam-A 6-79 (81) alignment 
Range on Protein: 542-616
Range on HMM: 6-79/81.0
RNAENVFGFGIHGGTDHR-NLPFIAHIADVaYAPSSPNrIAHGDAILRINDESTLTWSSEQCVQAITSSLNVLTLV
.. .. .|| ..||.|.| .  |....     |.   . .  || ||..|.... ..| ...||||... ...||.
kekrgglGfslkggsdkrdkgifvsevvpg.gaaeadg.lkeGDkIlsvNgvdvenvshdeavqaikgkkgevtLt
subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 1214-1319 2.1e-09 31.2 In-house 25-130 (302) alignment 
Range on Protein: 1214-1319
Range on HMM: 25-130/302.0
EGGLQTEFSRLQSVGLRHKSCAT-QANRDKNRYRNITAYDHSRVVLQVNPEeggcDYYNANYIAGARSPSDYIACQGPTNSSV---DDFWRMVWQQKTQC
.. ...|| .....     .| . ..| .||.  .. ..|. .| |. .|.    .|.||  .         |  | |. .|.   ..|||||.|.| . 
taevkkefkkidtmkvdlekCkafkknlkknqsedvpildsnlvkleaepd....syvnaskvevPeltrsiilaQlpkvdsedsveeFWrmvfqekivs

IVMVTNLEEQ
.|..   || 
vvilvgeeel
PDZ PDZ domain (Also known as DHR or GLGF) 342-421 6e-09 26.1 Pfam-A 4-81 (81) alignment 
Range on Protein: 342-421
Range on HMM: 4-81/81.0
VRRGADGLLGFSVVGGIEQDaLPAIALSD-AHSPHYEGQGyqLREGDELLAVDGHPVAGLSHAGVVDLFRQCESRVSLLIL
. .   | ||||..|| ...  . |  |.  . .  | .|  |.||| .|.|.| .|...||. .|.. ... . |.|.||
lekekrgglGfslkggsdkr.dkgifvsevvpggaaeadg..lkeGDkIlsvNgvdvenvshdeavqaikgkkgevtLtil
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 1418-1486 6.3e-09 29.6 In-house 265-340 (349) alignment 
Range on Protein: 1418-1486
Range on HMM: 265-340/349.0
TSPMLVHCSAGVGRSGTFIAIDHMLQLILDEA--RAASDVPD-VRDV----VHGMRDRRNFMVQTEEQYIFIYFAL
.|..||||||| ||.|... .| .|...          ...   .|.    |  .|  |  |||   |.|.|| ||
lstllvhcsaGcGrtGvlvtldlllsileplqnesnkiklqallkDlisiivnelrkqrismvqnlaqfiaiyeal
subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 1383-1500 7.5e-09 29.6 In-house 192-298 (310) alignment 
Range on Protein: 1383-1500
Range on HMM: 192-298/310.0
VTQFHMTAWPDHGVPSEPSDLLYFRqaIRAAFpnPTSPMLVHCSAGVGRSGTFIaidhMLQLILDEARAASDVpDVRDVVHGMRDRRNFMVQTEEQYIFI
|.  .   ||| ||| |    .  |  . |       | .||||||..| .. .     |.| .| ..    | |. .|.  .. .|   .||| ||..|
vslikwpnwpdrgvpdekchtvpqr..llaqv..rhgpcvvhcsagkdrlyvvv....alklkidkldrglkv.daeevktellksraiciqtelqylii

YFAlEMALtAMQATDKAD
 .   ... |   |..|.
drv.riif.argetevae
Ank Ankyrin repeat 159-189 1.2e-08 22.6 Pfam-A 2-32 (33) alignment 
Range on Protein: 159-189
Range on HMM: 2-32/33.0
GNSALHTAAHFGHVDVVHLLLQYQVDCHRLN
|...|| ||. |...|| |||..  | .  .
GfTPLHlAalrgnlevvklLlsqGAdlnaqd
subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 1238-1313 2e-08 28.1 In-house 36-116 (347) alignment 
Range on Protein: 1238-1313
Range on HMM: 36-116/347.0
ANRDKNRYRNITAYDHSRVVLQVNP-EEGGC----DYYNANYIAGARSPSDYIACQGPTNSSVDDFWRMVWQQKTQCIVMV
 . .||| ..    | .||||  .  . . .     | || .|    .  .||  | |  ..| |||.||   |   .| .
kslsknrskdvklidatrvvlspeksknsraddvetyinashikfdnaskeyiltqyplpdtvrdfwkmvsvtkvtqvvti
subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 1386-1488 2.2e-08 27.9 In-house 186-283 (302) alignment 
Range on Protein: 1386-1488
Range on HMM: 186-283/302.0
FHMTAWPDHGVPSEPSDLLYFRQAIRAAFPNPTSPMLVHCSAGVGRSGTFIAIDHMLQLILDEaraasDVPDVRDVVHGMRDRRNFMVQTEEQYIFIYFA
 ..| |... || . ..|    . . |   . ......    |.|| |.|..    .. . ..     . | . ..|. .|  |  .|.. .||...| |
yvltnWkqkkvpvkyaeliktaakvfakkikadentvivSknGaGRagafltlavaveklqkg.....kepnikeivksiRsqRpravdslkQyvslyia

LEM
| .
lll
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 1220-1280 3e-08 27.4 In-house 27-88 (440) alignment 
Range on Protein: 1220-1280
Range on HMM: 27-88/440.0
EFSRLQSvGLRH-KSCAT-QANRDKNRYRNITAYDHSRVVLQVNPEEGGCDYYNANYIAGARS
|.| | | || .    |.   |. ||||||| |||||||.|.        || || ||.|  |
ewsllps.glsqpsdiaslpnnkvknryrnilaydhsrvmleevkgvpdsdyinasyingies
Ank_3 Ankyrin repeat 159-184 4.6e-08 21.1 Pfam-A 2-27 (30) alignment 
Range on Protein: 159-184
Range on HMM: 2-27/30.0
GNSALHTAAHFGHVDVVHLLLQYQVD
||..||.||..|....|..||.. .|
GnTpLhlAasngrielvkyLlengad
subfamily_eak_pd Subfamily eak 1237-1410 6.5e-08 26.3 In-house 50-207 (332) alignment 
Range on Protein: 1237-1410
Range on HMM: 50-207/332.0
QANRDKNrYRNITAYDHSRVVLQVNpEEGGCDYYNANYIAGARSPSDYIACQGPTNSSVDDFWRMVWQQKTQCIVMVTNLEEQGRMKCLKYWPDLApgvs
  . ..|   .|  ||.  | |          | ||  .  .     ||    . .. |  ||.|| .||. .||.. .  |..  |  ||.|| .    
leavnrn.vvkivpydrylvrltss.qlnrlGyinaslaefsevGrkyiltGiasedkvfafwqmvleqkspaivqlledvelkleksdkyfpdkt....

addlRaDelpKLQLGPYVVFFKERHEHKLWTQRVFELEHeGEGRMTVTQFHMTAWPDHGVPSEpSDLLYFRQAI
    | .   .|. | . |  ||  ...    | .||.  |.    |  ...  | .  .|    |.| .|...
....r.e...elkfGildverkefvkrniletrllelsk.GnethrvlhykvfGwtettlpky.edflalrkvm
0038934 (Phosphotyrosine protein) phosphatases II 1385-1438 1.7e-07 26.6 In-house 81-135 (194) alignment 
Range on Protein: 1385-1438
Range on HMM: 81-135/194.0
QFHMTAWPDHGVPSEPSDLLYFRQAI-RAAFPNPTSPMLVHCSAGVGRSGTFIAI
...   .||.|..   . || | ... .    .|    .||| ||.||.||..| 
eylklpfpddgtvPsleillrfldlvdeflnedpggvvaVHCkaGlgRtGtlvaa
subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 1232-1279 3.7e-07 24.0 In-house 32-78 (244) alignment 
Range on Protein: 1232-1279
Range on HMM: 32-78/244.0
KSCATQANRDKNRYRNITAYDHSRVVLQVNPEEgGCDYYNANYIAGAR
 ..   ||  |||| ||  .|..||.|  . .| |.|| ||||| |..
tnavlsanatknryinilpfdetrvilssskke.gsdyinanyiqgsq
subfamily_Sponge-PTP3_pd Subfamily Sponge-PTP3 1226-1289 3.8e-07 24.2 In-house 35-95 (95) alignment 
Range on Protein: 1226-1289
Range on HMM: 35-95/95.0
SVGLRHKSCATQANRDKNRYRNITAYDHSRVVLQVNPEeggCDYYNANYIAGARSPSDYIACQG
. |  .   ...||  |||. ||  || .||||  . .    || || .. |      |||.||
tsgapytvgsseanipknrflnifpydatrvvlttkrd...sdyinacfvdgyarkncyiaaqg
subfamily_Sponge-PTP-2_pd Subfamily Sponge-PTP-2 1237-1402 9.8e-07 21.8 In-house 25-160 (169) alignment 
Range on Protein: 1237-1402
Range on HMM: 25-160/169.0
QANRDKNRYRNITAYDHSRVVLQVNPEEGGCDYYNAnyiagarspsdyiacqgptnssvddfwRMVWQQKTQCIVMVTNLEEQGRMKCLKYWPDLAPGVS
 .|  |||     |  | || ||   |. |.|| ||                           ||.|.  .  ||.. . ...  .   |   .| | | 
tcnetknrpagplapshtrvklqrvmedlgsdyina...........................rmiwetnasvivvlgdtddknnfwpekedyqlhpavi

ADDLRADELpklqlgpYVVFFKE----RHEHKLWTqrVFELEHEGEGRMT--VTQFHMTAWPDHGVPSEPSD
  .  .| |       ||   |     .  . |.   |  . |. .  .|  .. .| ..||. |||  |  
lgewytdsl.......yvrtdkvhantsgveglfe..vsmvihsydddvteklsllhystwpqngvpqspvh
subfamily_Sponge-PTP2_pd Subfamily Sponge-PTP2 1237-1402 1.5e-06 21.1 In-house 24-159 (169) alignment 
Range on Protein: 1237-1402
Range on HMM: 24-159/169.0
QANRDKNRYRNITAYDHSRVVLQVNPEEGGCDYYNAnyiagarspsdyiacqgptnssvddfwRMVWQQKTQCIVMVTNLEEQGRMKCLKYWPDLAPGVS
 .|  |||     |  | || ||   |. |.|| ||                           ||.|.  .  ||.. . ...  .   |   .| | | 
tcnetknrpagplapshtrvklqrvmedlgsdyina...........................rmiwetnasvivvlGdtddknnfwpekedyqlhpavi

ADDLRADELpklqlgpYVV----FFKERHEHKLWTQRVFELEHEGEGRMTVTQFHMTAWPDHGVPSEPSD
  .  .| |       ||       .    . |.   .   ... .    .. .|...||. |||  |  
lGewytdsl.......yvrtdkvhpntsgveglfevslvihsydddvteqlsllhystwpqngvpqspvh
subfamily_eak_pd Subfamily eak 1416-1486 1.8e-06 21.6 In-house 234-301 (332) alignment 
Range on Protein: 1416-1486
Range on HMM: 234-301/332.0
NPTSPMLVHCSAGVGRSGTFIAIDHMLQLILDEARaasDVPDVRDVVHGMRDRRNFMVQTEEQYIFIYFAL
 |.   .. .. |  |.|.|. || ...|| .  .   ..  | |..  ....|.  | .. |. ||| ..
ppsfapiiqsarGsaraGvfvvidllirlidnkkk...nlysvedlilkvkskrihsvlvalqhsfiyeiv
subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 1283-1334 2.8e-06 21.6 In-house 6-57 (199) alignment 
Range on Protein: 1283-1334
Range on HMM: 6-57/199.0
DYIACQGPTNSSVDDFWRMVWQQKTQCIVMVTNLEEQGRMKCLKYWPDLAPG
 |||.| |   .. |||.|||.  .  |||| . . .       |||    |
ryiatqhplretmadfwqmvwetgsghivmvnddqknkeadypfywpttesg
subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 1283-1334 2.8e-06 21.6 In-house 5-56 (198) alignment 
Range on Protein: 1283-1334
Range on HMM: 5-56/198.0
DYIACQGPTNSSVDDFWRMVWQQKTQCIVMVTNLEEQGRMKCLKYWPDLAPG
 |||.| |   .. |||.|||.  .  |||| . . .       |||    |
ryiatqhplretladfwqmvwetgsghivmvnddqknkeadypfywpttesg
PTEN_1 1380-1437 5.1e-06 21.4 In-house 92-149 (196) alignment 
Range on Protein: 1380-1437
Range on HMM: 92-149/196.0
RMTVTQFHmTAWPDHGVPSEPSDLLYFRQAIRAAFPNP-TSPMLVHCSAGVGRSGTFIA
.. |.. |   ..|||.||  . .   ...| ..  .|     |||| ||.||||| .|
ksgveylh.fpieDhgapslselfdicksfiewllsdpngnvVlVHCkaGlgRsGtvva
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 1283-1329 7.9e-06 19.4 In-house 237-280 (440) alignment 
Range on Protein: 1283-1329
Range on HMM: 237-280/440.0
DYIACQGPTNSSVDDFWRMVWQQKTQCIVMVTNLEEQgrmKCLKYWP
 .|| | | .|.| ||||.| . .   |.|. .|...    |  |||
afiatqmpldstvldfwrlvhdyristiimlnqlndk...tcsiywp