Gene MbrePTP-sf1-8 in Monosiga brevicollis

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily MbrePTP-sf1
Protein sequence
ID Type Fasta BLAST phosphatome Note
MbreP056_AA protein Get Run
MbreP056_AA_1199-1491 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_PTPRD_pd Subfamily PTPRD 1211-1510 5.2e-94 310.9 In-house 19-302 (564) alignment
Range on Protein: 1211-1510
Range on HMM: 19-302/564.0
LDAEGGLQTEFSRLQS-VGLRHKSCATQANRDKNRYRNITAYDHSRVVLQVNPEEGGCDYYNANYIAGARSPSDYIACQGPTNSSVDDFWRMVWQQKTQC
 . .  ...|. ....    . .... .||. |||| ||.|||||||||.  . . |.|| ||..| | |..  ||| |||......|||||||.|....
ansdlkfeeeykkieegqqftweaankpaNkaKNRyanivaYdhsRVvLskvegdegsDYINAsfidgyrkrkayIAtqgPlaetiedFWRmvweqnsst

IVMVTNLEEQGRMKCLKYWPDlapgvsaddlradELpKLQLGPYVVFFKERHEHKLWTQRVFELEHE-GEGRMTVTQFHMTAWPDHGVPSEPSDLLYFRQ
|||.|.|||.|. || ||||.             .  . . | ..| ..| .| .  . | |.|...  .  ..|.||| |.||||||| .. .|| ...
iVmltkleEkgkvkchkYWPe.............kg.tetygeltVtleeeeeladyeirtfklkkkkssesreVrqFhFtsWPdhgvpesatslLdlir

AIRAAFPNPTSPMLVHCSAGVGRSGTFIAIDHMLQLILDEaraasDVPDVRDVVHGMRDRRNFMVQTEEQYIFIYFALEMALTAMQAT-DKADLKMALDE
 .||. .. . |..|||||||||.||||.|| ||. | .|     .. |.. .|. .|  ||.|||||||||||. |.  ||....   .  .||..|..
kvralnepdagPivVhCSaGVGRTGtfividamlerikee.....ktvDiyqyvkalrkqRnamVqteeQYiFiheailealacgntevesenlkqhlqk

FHQ
 ..
Lae

subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 1205-1491 4.7e-90 296.5 In-house 4-277 (281) alignment
Range on Protein: 1205-1491
Range on HMM: 4-277/281.0
QHLQSKLDAE-GGLQTEFSRLQSVGLRHKSCATQ--ANRDKNRYRNITAYDHSRVVLQVNPEEGGCDYYNANYIAGARSPSDYIACQGPTNSSVDDFWRM
.||... . .  |...|.. |...|... . |..  .|. ||||.||.|||..||... | |.  .|| |||...| ... .|||.|||  .|...||.|
khlkqlsqndnaGfieeyeklaaigvdntataskadenvlknrYsnivaYDatrvkvtpneenkntDYinanfvpgykgekeyiatqgPvPaslvafWqm

VWQQKTQCIVMVTNLEEQGRMKCLKYWPDLAPgvsaddlradelpKLQLGPYVVFFKERHEHKLWTQRVFELEHEGEGRMTVTQFHMTAWPDHGVPSEPS
||.|| . |||||.  |.|..|| .|||| .              .|..| ..| .....|.. . .|.|.||.|.    .|.|.. |||||||||....
vweqkvsaivmvtreieagklkChrYWPddns.............elkygdvtvkstaeeekatyierkfkleresgetreveqlaytaWPdhGvPattk

DLLYFRQAI-RAAFPNPTSPMLVHCSAGVGRSGTFIAIDHMLQLILDEARAasdvPDVRDVVHGMRDRRNFMVQTEEQYIFIYFALEMALT
.|| ||... ..  ..   |...||||||||.||.||.| ... . .|..      ||..||. .| .||.||||  || |.| |.  || 
ellefrkevlkltekktkaplvihCsaGvGrtGtyialDrlvkaveaelee....ldvkavvaelrkernlmvqtvvqyefvykavldald

0051299 (Phosphotyrosine protein) phosphatases II 1210-1488 9.2e-88 289.7 In-house 18-284 (288) alignment
Range on Protein: 1210-1488
Range on HMM: 18-284/288.0
KLDAEGGLQTEFSRLQSVGLRH--KSCATQANRDKNRYRNITAYDHSRVVLQVNPEEGGCDYYNANYIAGARSPSDYIACQGPTNSSVDDFWRMVWQQKT
...   ||. || .|.|.   .  .... ..|..||||..| .||||||.|.| ....|.||.||.|| | ...  .||.|||....|.|||||||.|..
langltglleefeellsllpdltlsaallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyidgynlkrkfIatqgPlpntvedFWrmvweqnv

QCIVMVTNLEEQGRMKCLKYWPDlapgvsA----DdlradelpklqlGPYVVFFKERHEHKLWTQRVFELEH-----EGEGRMTVTQFHMTAWPDHGVPS
..|||.|.|.| || || .|||.                        |...| ... .... .|.|..|...      ..   |||.||.|.|||||||.
rvIvmltklvelgrekcaqYwpl......ggslty............gditvtllseevlddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpd

EPSDLLYFRQAIRAAFPNPTSPMLVHCSAGVGRSGTFIAIDHMLQLILDEaraasDVPDVRDVVHGMRDRRNFMVQTEEQYIFIYFALEM
 |..|| | ...| |.... .|..|||||||||.|||||.|..|.... |      ..|| ..|. .| .|..||||.|||.|.| || .
spellldflrlvrkalasgggpvvVHCsaGvgRtgtfialdllleqleke.....ggvdvleavkrlreqRpgmvqtpeqyrfvyealle

0050432 (Phosphotyrosine protein) phosphatases II 1197-1490 3.3e-87 288.0 In-house 25-299 (308) alignment
Range on Protein: 1197-1490
Range on HMM: 25-299/308.0
NEKVDAILQHLQSkLDAEGGLQTEFSRLQSVGLRHK--SCATQANRDKNRYRNITAYDHSRVVLqvnpeEGGCDYYNANYIAGA--RSPSDYIACQGPTN
.  |. .|..|.. ..  |.|..|| .|.||   ..  ... ..|.|||||..| .||||||.|     ..|.||.||.|. |   ..|  .||.|||..
klsvldllkllek.aldlglleeefeellsvkplleysvallpenkdkNrykdilpydhsRVkl.....degsdYInAsyvdgyssklprkfIatqgPlp

SSVDDFWRMVWQQKTQCIVMVTNLEEQGRMKCLKYWPDLAP-GV--SaddlradelpklqlGPYVVFFKERHEHKLWTQRVFELEH-EGEGRMTVTQFHM
..|.|||||||.|....|||.|.|.| || || .|||.    |.                 |...| ... .... .|.|..||.. ...   |||.||.
ntvedFwrmvweqnvrvIvmLtklvengrekcaqYwplelgggsley..............gkftvtllseevlddytvrtleltnlgdgesrtvthfhy

TAWPDHGVPSEPSDLLYFRQAIRAAFpnPTSPMLVHCSAGVGRSGTFIAIDHMLQLILDEaraasDVPDVRDVVHGMRDRRNFMVQTEEQYIFIYFALEM
|.|||||||..|..|| | ...|  .  | .|..|||||||||.|||||.|..|...  |       .|| ..|. .| .|..||||.|||.|.| || .
tnWpdhgvPpspeilldflelvrksl..pggpivVHCsaGvGRtGtfialdllleqleke.....ggvdvfeavkklReqRpgmvqtpeqylflyralle

AL
 |
yl

subfamily_PTPRB_pd Subfamily PTPRB 1204-1491 7.2e-87 286.1 In-house 13-286 (293) alignment
Range on Protein: 1204-1491
Range on HMM: 13-286/293.0
LQHLQ-SKLDAEGGLQTEFSRLQSVGLRHKS--CATQANRDKNRYRNITAYDHSRVVLQVNPEEGGCDYYNANYIAGARSPSDYIACQGPTNSSVDDFWR
 .|..  | |.. ... |...|..||  ..     ...||.||||.|| .|||||| |.   .| | || ||||| | .|| ..||.|||  ..||||||
eehvkkmkadsdlrfseeyeelkavgkdqavkaaelavnraknrytnilpydhsrvkLaalkdesgsDYinanyipgynsprefiatqGPlpetvddfWr

MVWQQKTQCIVMVTNLEEQGRMKCLKYWPDLapgvsaddlradeLPKLQLGPYVVFFKERHEHKLWTQRVFELEHeGEGRMTVTQFHMTAWPDHGVPSEP
|||..|.. |||.|.| |.|..|| .|||.                  . |   | ... .| . |. | ...|. .. ...|.|.| |.|||||||...
mvwekkssiivmltqlvekgkvkCeeYWPad.............eepvlyGdikvtlvaeeeledwvirelkiek.ekeerkvrqyhftsWpdhgvPekt

SDLLYFRQAIRAAF--PNPTSPMLVHCSAGVGRSGTFIAIDHMLQLILDearaaSDVPDVRDVVHGMRDRRNFMVQTEEQYIFIYFALEMALT
. || | ...| |    . ..|..|||||||||.|||||.|..|| | .     .|. |.  .|. .| .||..||||.|||||. ..   |.
ktlldfvrtvreaiektaskrPivvhCsaGvGRtGtfialdrllqaiee.....edyvdifgivaelReeRnllvqtekqYifihqcvldllr

0046845 (Phosphotyrosine protein) phosphatases II 1216-1489 3.4e-85 281.2 In-house 1-273 (284) alignment
Range on Protein: 1216-1489
Range on HMM: 1-273/284.0
GLQTEFSRLQSVGL----RHKSCATQANRDKNRYRNITAYDHSRVVLQVNPEE-GGCDYYNANYIAGA-----RSPSDYIACQGPTNSSVDDFWRMVWQQ
||. || .|.|.        . .. ..|..||||..| .||||||.|.. ... ...||.||.|. |      ...  .||.|||....|.|||||||.|
gleeefeellsltvklllslsvallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweq

KTQCIVMVTNLEEQGRMKCLKYWPDLaPGVSADdlradelpklqlGPYVVFFKERHEHKLWTQRVFELEHE--GEGRMTVTQFHMTAWPDHGVPSEPSDL
....|||.|.|.| || || .|||.   .|               |.. | ........ .|.|..||...  ..  .|||.||.|.|||||||..|.||
nvrvIVmltelvengrekcaqYwple.gevlty............gdftvtllseevkddytvrtleltnlgytgesrtvthfhytswpdhgvppspedl

LYFRQAIRAAFP--NPTSPMLVHCSAGVGRSGTFIAIDHMLQLILDEARAasDVPDVRDVVHGMRDRRNFMVQTEEQYIFIYFALEMA
| | ...| ...  .. .|..|||||||||.|||||.|..|...  | .    ..|| ..|. .|..|..||||.|||.|.| || ..
leflrlvrellenlpgggpivVHCsaGvgRtGtfialdllleqlekegll..lgvdvleavkrlreqRpgmvqtleqyrfvyealley

0036941 (Phosphotyrosine protein) phosphatases II 1214-1489 1e-82 273.1 In-house 12-276 (297) alignment
Range on Protein: 1214-1489
Range on HMM: 12-276/297.0
EGGLQTEFSRLQSVGLRHK--SCATQANRDKNRYRNITAYDHSRVVLqvnpEEGGCDYYNANYIAGARSPSDYIACQGPTNSSVDDFWRMVWQQKTQCIV
  .|..||..|... |  .    . ..|..||||..| .|||.||.|    ...|.||.||.|. | . .  .||.|||....|.|||||||.|....||
lalllkefeellpllllgslsvallpenleknRykdilpydhtRVkl....ddegsdYinAsyvdgydlkrkfIatqgPlpntvedFWrmvweqnvtvIv

MVTNLEEQGRMKCLKYWPDLAPGVSADdlradelpklqlGPYVVFFKERHE--HKLWTQRVFELEH-EGEGRMTVTQFHMTAWPDHGVPSEPSDLLYFRQ
|.|.|.| || || .|||.  ...               |...|.... ..  .. .|.|..|... ...   |||.||.| |||||||. |..|| | .
mltelvelgrekcaqywpleegeslty............gdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfie

AIRAAFPN--PTSPMLVHCSAGVGRSGTFIAIDHMLQLILDEarAASDVPDVRDVVHGMRDRRNFMVQTEEQYIFIYFALEMA
..| . ..  . .|.||||||||||||||||.| |||.. |.       .|. ..|. .|..|...|||.|||.|.| || . 
lvrkvlkllpsggpvlVHCsaGvgRsgtfiaadlmlqqledk..lkeggvdileavkklReqRpgavqtleqyrflyeallel

0040438 (Phosphotyrosine protein) phosphatases II 1215-1490 1.7e-82 272.5 In-house 18-276 (317) alignment
Range on Protein: 1215-1490
Range on HMM: 18-276/317.0
GGLQTEFSRLQSVGLRHKSC-ATQANRDKNRYRNITAYDHSRVVLQVNPEEGGCDYYNANYIAGARSPSDYIACQGPTNSSVDDFWRMVWQQKTQCIVMV
..|. || .|.|. | . |. . ..|.|||||..|  ||||||.|.. ..  ..||.||.|. | . .  .||.|||....|.|||||||.|....|||.
talleefedllslkldtysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyvdgpnlkrkfIatqgPlpntvedFwrmvweqgvtvivmL

TNLEEQGRMKCLKYWPDlapgvsA----DdlradelpklqlGPYVVFFKERHEHKLWTQRVFELEH-EGEGRMTVTQFHMTAWPDHGVPSEPSDLLYFRQ
|.||| || || .|||.                        |...| ... .|.. .| |..|.|. ...   |||.||.|.|||||||. |..|| | .
teleelgrekcaqYwpl......getlty............gdftvtllseeelagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfle

AIRAAFPNPTSPMLVHCSAGVGRSGTFIAIDHMLQLILDEAraasdVPDVRDVVHGMRDRRNFMVQTEEQYIFIYFALEMAL
|.|.|...| .|.||||||||||.|||||.. ||...  |       .|| ..|. .| .|. .|||.|||.|.| || . |
avrealedpggpvlVHCsaGvgRtGtfiaaylmleqlekeg.....gvdveeavkelreqRpgavqtpeqyrflydalleyl

0039614 (Phosphotyrosine protein) phosphatases II 1208-1486 4.9e-82 271.0 In-house 25-285 (297) alignment
Range on Protein: 1208-1486
Range on HMM: 25-285/297.0
QSKLDAEGGLQTEFSRLQSVGLRHKSCATQANRDKNRYRNITAYDHSRVVLQVNPEE-GGCDYYNANYIAGARS-PSDYIACQGPTNSSVDDFWRMVWQQ
  |..  ..|..|| .|.|.    . .. ..|.|||||..| .||||||.|.....   ..||.||.|. | .  . ..||.|||....|.|||||||.|
lekansktllllefeellslkpdysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfIatqgPlpetvedFwrmvweq

KTQCIVMVTNLEEQGRmKCLKYWPDLAPgvsaddlradelpklQLGPYVVFFKERHEHKLWTQRVFELEHeGEGRMTVTQFHMTAWPDHGVPSEPSDLLY
....|||.|.|.| || || .|||.                  . |...| ... .... .|.|..|... ..   |||.|. | |||||||. ...|| 
gvtvivmLtklvelgr.kcaqywpeegg...............tygdftvtllkvehldgytvrtlevtn.ngesrtvthfqytgwpdhgvppslellle

FRQAIRAAFPN--PTSPMLVHCSAGVGRSGTFIAIDHMLQLILDEaraasDVPDVRDVVHGMRDRRNFMVQTEEQYIFIYFAL
| ...| |. .  .  |.||||||||||.|||||.. ||...  |       .|| ..|. .| .|. .|||..||.|.| ||
flelvrealaelpkggpvlVHCsaGvgRtGtfiaaylmleqleke.....ggvdvleavkelreqRpgavqtpsqyrflydal

subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 1211-1509 2.1e-81 268.4 In-house 14-300 (318) alignment
Range on Protein: 1211-1509
Range on HMM: 14-300/318.0
L--DAEGGLQTEFSRL---QSVGLRHKScATQANRDKNRYRNITAYDHSRVVLQVNPEEGGCDYYNANYIAGARSPSDYIACQGPTNSSVDDFWRMVWQQ
|  . |  |..|. ||   ..   ..||  ...|. |||| ||.||||.|| ||   .| | || ||||| | |.   |||.|.|    ..|||||||.|
lresGelllseeyerlsrseetvtslks.lepvnkaknryanilaydhtrvkLqmlegeegsDyinanyidGyrrkkayiaaqaPlpetieDfWrmvWeq

KTQCIVMVTNLEEQGRMKCLKYWPDLAPgVSADDLRADELPKLQLGPYVVffkerhehklwtqRVFELEHEGEG-RMTVTQFHMTAWPDHGVPSEPSDLL
... |||.|..||.|..|. .|||.  .  | ..|. .   ...|. ||.             | |......|    .| |.|.|.|||.|||.....||
nsavivmltqeeergkakvhryWPskgs.rsygklvvelkeevelsdyvl.............refkvtrteeeesrqvrqyhytsWpdegvpesgasll

YF-RQAIRAAFPNPTSPMLVHCSAGVGRSGTFIAIDHMLQLILDEARAasdvpDVRDVVHGMRDRRNFMVQTEEQYIFIYFALEMALTAMQAT-DKADLK
 . ||. .|  .. ..|..||||||||| |.|||.| .|. | .||       || ..|. .|..|| |||||.||.||| .|  ||.. ..  |  ||.
dlvrqvskaqqksgagpivvhCsaGvGrtGvfiavdillerikaealv.....Dvfqtvkqlreqrnlmvqtedqyefiydvllealasgdtevdasdlr

MALDEFH
  . |..
srirelr

0047943 (Phosphotyrosine protein) phosphatases II 1208-1486 2.6e-81 268.4 In-house 5-268 (273) alignment
Range on Protein: 1208-1486
Range on HMM: 5-268/273.0
QSKLDAEGGLQTEFSRLQSVGLRH--KSCATQANRDKNRYRNITAYDHSRVVLqvnpEEGGCDYYNANYIAGARSPSDYIACQGPTNSSVDDFWRMVWQQ
  ||.  ..|. || .|.|.   .  . .. ..|.|||||..| .||||||.|    ..||.||.||.|. | ...  .||.|||....|.|||||||.|
lekllgltllleefelllslkplltysvallpenkdknrykdilpydhsrvkl....gdggsdyinAsyvdgynlkrkfiatqgPlpntvedfwrmvweq

KTQCIVMVTNLEEQGRMKCLKYWPDLapgvsaddlraDELPKLQLGPYVVFFKERHEHKLWTQRVFELEH-EGEGRMTVTQFHMTAWPDHGVPSEPSDLL
....|||.|.|.| || || .|||.             .  .|. |.. | ... .... .|.|..||.. . .   |||.||.| |||||||. ...||
nvrviVmLtelvelgrekcaqYwple...........ggelsltygkftvtllseetkddytvrtleltnlgtgesrtvthfhytgwpdhgvppslesll

YFRQAIRAAFPN--PTSPMLVHCSAGVGRSGTFIAIDHMLQLILDEaraasDVPDVRDVVHGMRDRRNFMVQTEEQYIFIYFAL
 | ...| |. .    .|..|||||||||.|||||.|..|...  |       .|| ..|. .|..|  ||||.|||.|.| ||
efielvrkalealpsngpvvVHCsaGvgRtgtfialdllldqleke.....ggvdvleavkllrsqRpgmvqtpeqyrflyeal

0045450 (Phosphotyrosine protein) phosphatases II 1205-1486 6.5e-80 264.4 In-house 17-300 (307) alignment
Range on Protein: 1205-1486
Range on HMM: 17-300/307.0
QHLQSKLDAEGGLQTEFSRLQSVGL----RHKSCATQANRDKNRYRNITAYDHSRVVLQVNPEE-GGCDYYNANYI--------AGARSPSDYIACQGPT
. |. .||   ||. || .|.||       ... . ..|.|||||..| .|||.||.|.. ... ...||.||.|.         | ...  .||.|||.
lvllllldfltgllkefekllsvtvfllgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydlkrkfIatqgPl

NSSVDDFWRMVWQQKTQCIVMVTNLEEQGRMKCLKYWPDLaPGvsaddlradelpKLQLGPYVVFFKERHEHKLWTQRVFELEH--EGEGRMTVTQFHMT
...|.|||||.|.|....|||.|.|.| || || .||||   .            .|. |...| ... .... .| |..|...  . .   |||.||.|
petvedFwrmlweqgvtvivmltelvelgrekcaqywPde.ge............eltygnftvtllseehldgytvrtlevtdldgtgesrtvthfhyt

AWPDHGVPSEPSDLLYFRQAIRAAFPN--PTSPMLVHCSAGVGRSGTFIAIDHMLQLILDEARAASdvPDVRDVVHGMRDRRNFMVQTEEQYIFIYFAL
.|||||||. ...|| | ...|.|. .  . .|.||||||||||.|||||.. ||... .|       .|....|. .|..|  .||..|||.|.| ||
gwpdhgvppsfeelldfieevrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlld..vdlleavkllreqRpgavqnpeqyrflyeal

0043336 (Phosphotyrosine protein) phosphatases II 1209-1486 1.3e-79 262.9 In-house 14-273 (278) alignment
Range on Protein: 1209-1486
Range on HMM: 14-273/278.0
SKLDAEGGLQTEFSRLQSVGLRHKSCAT-QANRDKNRYRNITAYDHSRVVLQVNPEEGGCDYYNANYIAGARSPSDYIACQGPTNSSVDDFWRMVWQQKT
 .|.   .|. || .|.|. | ..|.|  ..|.|||||..| .||||||.|.. ... ..||.||.|. | . | ..||.|||....|.|||||||....
lllnlktllllefeellsfkldtysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyvdgynvprkfiatqgPlpetvedFwrmvwelgv

QCIVMVTNLEEQGRMKCLKYWPdlapgvsaddlradeLPKLQLGPYVVFFKERHEHKLWTQRVFELEH-EGEGRMTVTQFHMTAWPDHGVPSEPSDLLYF
..|||.|.|.| || || .|||                  |. |...| ... .... .|.|..|...       |||..| ..|||||||. .|.|| |
ttivmLtelvelgrvkcaqYwp...............ggsltygdftvtllkeehlddytvrtlevtnlgdgesrtvthyhylgwpdhgvpeslsllldf

RQAIRAAFPNPTSPMLVHCSAGVGRSGTFIAIDHMLQLILDEAraasdVPDVRDVVHGMRDRRNFMVQTEEQYIFIYFAL
 .|.| |.... .|.||||||||||.|||||.. .|... .|       .|. ..|. .| .|  .|||..||.|.| ||
lkavrealedsngpvlVHCsaGvgRTGtfialyllleqlekeg.....gvdleeavkelreqRpgavqtpsqyrflyeal

DSPc_SM00195 1217-1486 3e-79 261.4 In-house 2-258 (263) alignment
Range on Protein: 1217-1486
Range on HMM: 2-258/263.0
LQTEFSRLQSVG--LRHKSCATQANRDKNRYRNITAYDHSRVVLQVNPEEGGCDYYNANYIAGARSPSDYIACQGPTNSSVDDFWRMVWQQKTQCIVMVT
|..||..|..     . .. . ..|..||||.||  |||.|| |. .... | ||.||||| ||.....|||.|||..| |.|||||||..|...|||.|
lkeefekleestspketteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlt

NLEEQGRMKCLKYWPDLApgvsaddlradeLPKLQLGPYVVFFKERHEHK-LWTQRVFELEHEG-EGRMTVTQFHMTAWPDHGVPSEPSDLLYFRQAIRA
. ||.|. || .|||. .              | . | . | ..| ...|  ...|..||..|| |   .|||.....|||||||......| . .|.. 
eeeengkekcdrywpees............ggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkk

AFPNPTSPMLVHCSAGVGRSGTFIAIDHMLQLILDEARaasdvPDVRDVVHGMRDRRNFMVQTEEQYIFIYFAL
   . ..|..|||||||||.|||..|| .|. . .| .     .|. ..|  .|. |  ||||.|||.||| |.
skstssgpivVhCsaGvgRtgtfvtidiilskleeekk.....vdifeivkelRkqRpgmvqtleqYlfiyeai

PTPc_SM00194 1217-1486 3e-79 261.4 In-house 2-258 (263) alignment
Range on Protein: 1217-1486
Range on HMM: 2-258/263.0
LQTEFSRLQSVG--LRHKSCATQANRDKNRYRNITAYDHSRVVLQVNPEEGGCDYYNANYIAGARSPSDYIACQGPTNSSVDDFWRMVWQQKTQCIVMVT
|..||..|..     . .. . ..|..||||.||  |||.|| |. .... | ||.||||| ||.....|||.|||..| |.|||||||..|...|||.|
lkeefekleestspketteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlt

NLEEQGRMKCLKYWPDLApgvsaddlradeLPKLQLGPYVVFFKERHEHK-LWTQRVFELEHEG-EGRMTVTQFHMTAWPDHGVPSEPSDLLYFRQAIRA
. ||.|. || .|||. .              | . | . | ..| ...|  ...|..||..|| |   .|||.....|||||||......| . .|.. 
eeeengkekcdrywpees............ggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkk

AFPNPTSPMLVHCSAGVGRSGTFIAIDHMLQLILDEARaasdvPDVRDVVHGMRDRRNFMVQTEEQYIFIYFAL
   . ..|..|||||||||.|||..|| .|. . .| .     .|. ..|  .|. |  ||||.|||.||| |.
skstssgpivVhCsaGvgRtgtfvtidiilskleeekk.....vdifeivkelRkqRpgmvqtleqYlfiyeai

subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 1208-1487 3.2e-76 251.1 In-house 14-276 (288) alignment
Range on Protein: 1208-1487
Range on HMM: 14-276/288.0
QSKLDAEGGLQTEFSRLQSVGLRHKSCATQ--ANRDKNRYRNITAYDHSRVVLQVNPEEGGCDYYNANYIAGARSPSDYIACQGPTNSSVDDFWRMVWQQ
. . ... |.. |.  | ...  ....|..   | .||||||| .||. || |.  .|| | || ||.||.| ..   ||| |||  ..|.|||..|...
kksarnrtgfseeynsLaalektksvtagrlavnakknRyrnilpyDekrvklkkleeeagaDYinasyidgekkkkkyiatqgPladtvndfWelvyen

KTQCIVMVTNLEEQGRMKCLKYWPDlapgvsaddlraDELPKlQLGPYVVFFKERHEHKLWTQRVFELEhEGEGRMTVTQFHMTAWPDHGVPSEPSDLLY
||. |||.|.| |.|. || .||||            .. || . |   |  .| .| . ...| ..||   ......||.. .||||||||    .|| 
ktstivmltelveggktkCeeYWPd............adkpk.nyGsvtvtlveskeledfvlrkllle.kkkteleitqyqylaWpdhgvPeskaplle

FRQAIRAAFPNPTSPMLVHCSAGVGRSGTFIAIDHMLQLILDearaaSDVPDVRDVVHGMRDRRNFMVQTEEQYIFIYFALE
... .  | .. | |..|||||||||.|||||.| ... .       .|. || ..|. .| .|...|||..||.||| .| 
llrqvkvanqadtgpiivhCsaGvGrtgtFialdalidavee.....edyiDvagtvaklRkqRallvqtlkqYefiyevll

0040439 (Phosphotyrosine protein) phosphatases II 1234-1488 3.9e-74 244.7 In-house 6-244 (249) alignment
Range on Protein: 1234-1488
Range on HMM: 6-244/249.0
CATQANRDKNRYRNITAYDHSRVVLQVNPEEGGCDYYNANYIAGARSPSDYIACQGPTNSSVDDFWRMVWQQKTQCIVMVTNLEEQGRMKCLKYWPDlap
.  ..|.|||||..| .||||||.|.. |.  ..||.||.|| | ... ..||.|||....|.|||||.|... ..|||.|.|.| || || .|||.   
allpenkdknrypdilpydhsrvklsilpglflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywpl...

gvsA----DdlradelpklqlGPYVVFFKERHEHKLWTQRVFELEH-EGEGRMTVTQFHMTAWPDHGVPSEPSDLLYFRQAIRAAFPN--PTSPMLVHCS
                     | ..| ... .... .|.|..||.. .     ||.....| |||||||. ..||| | .|.| |. .  . .|.|||||
...ggsley............gdftvtllsvevkddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCs

AGVGRSGTFIAIDHMLQLILDEARaasdvPDVRDVVHGMRDRRNFMVQTEEQYIFIYFALEM
|||||.|||||.. ||...  | .      |. ..|. .|..|. .||..|||.|.| || .
aGvgRtGtfiaaylmleqlekelg.....vdleeavkllrsqRpgavqnpeqyrflyealle

Y_phosphatase Protein-tyrosine phosphatase 1239-1486 4.3e-74 244.2 Pfam-A 1-233 (235) alignment
Range on Protein: 1239-1486
Range on HMM: 1-233/235.0
NRDKNRYRNITAYDHSRVVLqvNPEEGGCDYYNANYIAGARSPSDYIACQGPTNSSVDDFWRMVWQQKTQCIVMVTNLEEQGRMKCLKYWPdlapgvsad
|..||||..|..||..|| |  . .|| .||.||||. | .... .||.|||..|...||||||||.|...|||.|.|||.|| || .|||         
nkkknRykdilpydktrvkl..kgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwp.........

dlRADELpKLQLGPYVVFFK-ERH-EHKLWTQRVFELEHEGEGR--MTVTQFHMTAWPDHGVPSEPSDLLYFRQAIRAAFPNPTSPMLVHCSAGVGRSGT
  ...|  .|. | . |  | . . ..| .| |..||....| .   .|.|.|.|.|||||||..|..|| . ....    . ..|..|||||||||.||
..eeeee.sltygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgt

FIAIDHMLQLILDEARaasdvPDVRDVVHGMRDRRNFMVQTEEQYIFIYFAL
|.|.| .|. . .|       .|| ..|  .| .|. |||..|||||.| |.
fvaldilleqleaeee.....vdvlqivkelRkqRpgmvqsleqYiflykai

Y_phosphatase Protein-tyrosine phosphatase 1239-1486 4.3e-74 244.2 In-house 1-233 (235) alignment
Range on Protein: 1239-1486
Range on HMM: 1-233/235.0
NRDKNRYRNITAYDHSRVVLqvNPEEGGCDYYNANYIAGARSPSDYIACQGPTNSSVDDFWRMVWQQKTQCIVMVTNLEEQGRMKCLKYWPdlapgvsad
|..||||..|..||..|| |  . .|| .||.||||. | .... .||.|||..|...||||||||.|...|||.|.|||.|| || .|||         
nkkknRykdilpydktrvkl..kgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwp.........

dlRADELpKLQLGPYVVFFK-ERH-EHKLWTQRVFELEHEGEGR--MTVTQFHMTAWPDHGVPSEPSDLLYFRQAIRAAFPNPTSPMLVHCSAGVGRSGT
  ...|  .|. | . |  | . . ..| .| |..||....| .   .|.|.|.|.|||||||..|..|| . ....    . ..|..|||||||||.||
..eeeee.sltygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgt

FIAIDHMLQLILDEARaasdvPDVRDVVHGMRDRRNFMVQTEEQYIFIYFAL
|.|.| .|. . .|       .|| ..|  .| .|. |||..|||||.| |.
fvaldilleqleaeee.....vdvlqivkelRkqRpgmvqsleqYiflykai

0042113 (Phosphotyrosine protein) phosphatases II 1234-1486 4.1e-73 241.1 In-house 4-239 (245) alignment
Range on Protein: 1234-1486
Range on HMM: 4-239/245.0
CATQANRDKNRYRNITAYDHSRVVLQVNPEEGGCDYYNANYIAGARSPSDYIACQGPTNSSVDDFWRMVWQQKTQCIVMVTNLEEQGRMKCLKYWPDlaP
.. ..|.|||||..| .|||.||.|.. ... ..||.||.|. | | .  .||.|||....|.|||||.|... ..|||.|..|| || || .|||.   
allpenkdknrysdilpydhtrvklspdggdldsdyinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywpl..g

GVSADdlradelpklqlGPYVVFFKERHEHKLWTQRVFELEH-EGEGRMTVTQFHMTAWPDHGVPSEPSDLLYFRQAIRAAFP-NPTSPMLVHCSAGVGR
..               | ..| ... . .. .|.|..|...       .|...| . |||||||. ...|| | ...| |   ..  |.||||||||||
eslty............gdftvtllseehlddytvrtlevtnlgddesrevihyhylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgR

SGTFIAIDHMLQLILDEAraasdVPDVRDVVHGMRDRRNFMVQTEEQYIFIYFAL
.|||||.. ||...  |        .. ..|. .|..|  .|||..||.|.| ||
tGtfiaaylmleqlekel.....gvsleeavkelrsqRpgavqtpsqyrflyeal

subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 1214-1494 2.9e-72 238.4 In-house 26-294 (298) alignment
Range on Protein: 1214-1494
Range on HMM: 26-294/298.0
EGGLQTEFSRLQSVGL-----RHKSCATQANRDKNRYRNITAYDHSRVVLQVNPEEGGCDYYNANYIAGARSPSDYIACQGPTNSSVDDFWRMVWQQKTQ
  |...|| ||.||        ..   ...|..|||| .| |.|.|||||. . ..  .|| || .. ...  . .||.|.| ...| ||||||.... .
ltgyalefqrlnsvsseieeeekevarkpenkkkNRyadiialdssRvvLekedadeesdYiNAsflhaykgrnafiatqaPltetvedFWrmvteedig

CIVMVTNLEEQGRMKCLKYWPDLAPgVSADDLRAdelpklqlgpyvvFFKERHEHKLWTQRVFELEHEG-EGRMTVTQFHMTAWPDHGVPSEPSDLLYFR
.|||.|||||....|. |||||       ....                ....|.   ..| ......  |.. .| |.|.| |||.|||.. . .| ..
tiVmltnleeldktkyhkywPdegk.etygeitv.............sllskeefadlivrklkvskkkeekerevrqlhftsWpdkgvpenatsvldll

QAIRAaFPNPTS--PMLVHCSAGVGRSGTFIAIDHMLqlilDEARAaSDVPDVRDVVHGMRDRRNFMVQTEEQYIFIYFALEMALTAMQ
. .||  .. .   |..|.||||||||||||||| .|    . ... . | ||..||. .| .|  .|||||||.||| |   ||.. .
rkvra.sqqqagnkpvivqCsaGvgRsGtfiaidsvl....ervkk.eqvvDvfqvvkvlRkkrpgavqteeqYvfiyeavlealdsfn

0045098 (Phosphotyrosine protein) phosphatases II 1220-1488 3.2e-72 238.6 In-house 14-270 (278) alignment
Range on Protein: 1220-1488
Range on HMM: 14-270/278.0
EFSRLQSVGLRHKSCATQANRDKNRYRNITAYDHSRVVlqvnpeeggcDYYNANYIAGArsPSDYIACQGPTNSSVDDFWRMVWQQKTQCIVMVTNLEEQ
|| .|..   .        |.|||||..| .||||||.          || ||.|| |   |  .||.|||..| |.|||||.|......|||.|.|.| 
efllllgipseitpalylgnldknRykdilpydhsrVk..........dYINAsyidgy..pkkfIatqgPlpstvadfwrmlwelgitvivmltelvel

GRMKCLKYWPDlaPGVS-AddlradelpklqlGPYVVFFKERHEHKLWTQRVFELEH-----EGEGRMTVTQFHMTAWPDHGVPSEP--SDLLYFRQAIR
|| || .|||.   |.                |...| ... .... .| |......     |.   ..||..|.. ||||||||.|  . .| . . ||
grekcaqywpe..ggslty.............gdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefir

AAFPN-------------PTSPMLVHCSAGVGRSGTFIAIDHMLQLIldearaaSDVPDVRDVVHGMRDRRNF-MVQTEEQYIFIYFALEM
.|  .             .  |.||||||||||.||..|.. ||.|.        .. |. ..|. .| .|.. .||..|||.|.| .| .
ealkllaslllsslllldsggpvlVHCsaGvgRtGtlvaaylmlell.......eggvdlleavkelrsqRpglavqnleqyrflyeflle

subfamily_PTPRG_pd Subfamily PTPRG 1206-1495 8.5e-72 237.1 In-house 9-292 (563) alignment
Range on Protein: 1206-1495
Range on HMM: 9-292/563.0
HLQS-KLDAEGGLQTEFSRLQS----VGLRHKSCATQANRDKNRYRNITAYDHSRVVLQVNPEEGG-CDYYNANYIAGARSPSDYIACQGPTNSSVDDFW
|. | . |.. |.. ||  |||      |  ..   . |. |||| ||.|||.||| |.  |.. .  || ||||| | .   ..|| ||| .. .||||
hvaslhadgdigfseefealqsetiskdldaehsqkpenkrKnRylnivaydrsRvklsplpgkkkklDYinAnyidGyqkskafiatqgplkdtfddFW

RMVWQQKTQCIVMVTNLEEQGRMKCLKYWPDlAPGVSADDLRADELPKLQLGPYVVFfkerhehKLWTQR-VFELEHEGEGRMTVTQFHMTAWPDHGVPS
||.|.|... |||.|||.|.|| ||  |||     .  . |.     . .|  | |        .|  .    . ... .   .|.|.|.| |||||||.
rmiWeqnvaiivmitnlvergrrkcdvYWPk.desetygalqvtlieeevlalytvr.......tlviknlklkkkkqcdteklvrqyhytkWPdhgvPe

EPSDLLYFRQAIRAAFPNPTSPMLVHCSAGVGRSGTFIAIDHMLQLILDEaraasDVPDVRDVVHGMRDRRNFMVQTEEQYIFIYFALEMALTAMQA
 .   | | .   || .. . |..|||||||||.||.|..| .|. | .|     .. .| .... .| .|||.|||||||||.. ||  |... . 
hslpvLifvkkssaankaeaGPivvHcsaGvgrtGtyivldtllkqiqqe.....navnvfgflkhiraqRnflvqteEqYiflhdalleaiasket

subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 1204-1511 8.9e-71 233.5 In-house 14-305 (319) alignment
Range on Protein: 1204-1511
Range on HMM: 14-305/319.0
LQHLQSklDAEGGLQTEFSRLQS-VGLRHKSCATQANRDKNRYRNITAYDHSRVVLQVNPEEGGCDYYNANYIAGARSPSDYIACQGPTNSSVDDFWRMV
|..|.|   .| .|. ||  |.  |    .|. .. |..||||.|| |||..||||.  ..  | || ||..| | .  . .|| |.| .  ..||||||
lkalas..tgetllekefkllkeavndtfdsaskeenkkknryqnilaydrtrvvlseldgvegsdyinasfidgyqerekfiatqaPlentiedfWrmv

WQQKTQCIVMVTNLEEQGRMKCLKYWPDLAPgvsaddlradelpkLQLGPYVVFFKERHEHKLWTQRVFELEHEGeGRM---TVTQFHMTAWPDHGVPSE
|.... ..||.|.| |....|. ||||.  .               . | ..|  .|..| . .  | ..|..   . .   .|..|. |.||||.|| .
Weeessivvmltklveklkvklkkywpeenf..............eeyGrlivtleeeeeledyiirklklnkks.sevetRevkhfqyteWpdhdvPek

PSDLLYFRQAIRAAFPN-PTSPMLVHCSAGVGRSGTFIAIDHMLQLILDEAraasdVPDVRDVVHGMRDRRNFMVQTEEQYIFIYFALEMALTAMQ-ATD
   || . . || .  .    |. ||||||||| ||||..| ||. .  |.     | ||  .|  .|  ||.|||..|||.||| ||  |..| .   .
atslldllkrirksrektqsgPivvhCsaGvGRtGtfivldamlervkeeg.....vlDvfstvsrlRtqRnimvqrpeqYkfiyealleaveagdteie

KADLKMALDEFHQH
  ||.. | .. ..
vqdlrdrlkqlaek

subfamily_PTPN6_pd Subfamily PTPN6 1206-1492 5.4e-70 230.8 In-house 18-299 (306) alignment
Range on Protein: 1206-1492
Range on HMM: 18-299/306.0
HlQSKLDAEGGLQTEFSRLQSVGLR----HKSCATQANRDKNRYRNITAYDHSRVVLQvNPEEGGCDYYNANYIAGARS--PSDYIACQGPTNSSVDDFW
. ...  .  |.. || .||    .    .|  | . |. ||||.||  .||.||.|. .|.  | || ||||| ..       ||| ||  .. | |||
k.eeeslekagfeeefeelqqeeakkllsrkegakpenkeknryknilPfDhtrvilk.epsvpgsdyinanyikkevkgsdksyiatqgclettvsdFW

RMVWQQKTQCIVMVTNLEEQGRMKCLKYWPDLAPGVSADDLRADELPKLqlgpyvvffkerhEHKLWTQRVFELEH--EGEGRMTVTQFHMTAWPDHGVP
|||||.... |||.|.  |.|. || .||||     .  ...  .. .              ... .. | . ...  ...   .| |.| ..|||||||
rmvwqensrvivmttkevErgkekCarYWPdeeekeeyGkisvtnvsek.............sladYilRelsvskkkkkkeerevfqyhfksWPdhgvp

SEPSDLLYFRQAIRAAFPNPT----SPMLVHCSAGVGRSGTFIAIDHMLQLILDEARAAsDVpDVRDVVHGMRDRRNFMVQTEEQYIFIYFALEMALTA
..|. .| | . ...   . .     |..||||||.|| |||| || .|.||  .   | |. |....|. .|. |. .||||.|| |.| |... . .
kdpgavLdfledvnrkqeeleeaeagpivvhCsaGiGRtGtfiviDillkliekkglda.di.diqklvksvreqrsglvqteqqykfvykaikkyiet

0037934 (Phosphotyrosine protein) phosphatases II 1235-1486 6.2e-70 230.8 In-house 6-238 (243) alignment
Range on Protein: 1235-1486
Range on HMM: 6-238/243.0
ATQANRDKNRYRNITAYDHSRVVLqvnpeEGgCDYYNANYIAGArsPsDYIACQGPTNSSVDD----FWRMVWQQKTQCIVMVTNLEEQGRMKCLKYWPd
  ..|..||||..| .||||||.|     || .||.|||.| .   |  .||.|||....|.|    ||||.|......|||.|.|.| || || .||| 
llpenlsknrysdilpydhsrvkl.....eg.sdyinanliyvt..p.rliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywp.

lapgvsaddlraDELpklQLGPYVVFFKERHEHKLWTQRVFELEH--EGEGRMTVTQFHMTAWPDHGVPSEPSDLLYFRQAIRAA--------FPNPTSP
            .|    . |...| ... .... .|.|...||.  ...   .|...| ..|||||||..|.||| | ...|.           .. .|
............gev...tygdftvtllseehlddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggp

MLVHCSAGVGRSGTFIAIDHMLQLIldearaasDvPDVRDVVHGMRDRRNF-MVQTEEQYIFIYFAL
.||||||||||.||.||.. ||.|.        .  |. ..|. .|..|.. .|||..||.|.| ||
vlVHCsaGvgRtGtliaaylmllll........g.vdleeavkllreqRpgkavqtpsqyrflyeal

subfamily_PTPRA_pd Subfamily PTPRA 1217-1509 4.2e-68 224.7 In-house 34-315 (330) alignment
Range on Protein: 1217-1509
Range on HMM: 34-315/330.0
LQTEFSRLQS--VGLRHKSCATQANRDKNRYRNITAYDHSRVVLQVNPEEGGCDYYNANYIAGARSPSDYIACQGPTNSSVDDFWRMVWQQKTQCIVMVT
.. ||  | .  .    . .. . |..|||. ||  ||.|||.|.|   .   || || .| | .    .||.||| . .|.|||||.|.||.. |||.|
freefnalPagpiqatlelaskeenkeknrvvnilPydfsrvilsvkeGveesdyinasfidGykekdkfiaaqGPkeetvedfwrmiweqksativmlt

NLEEQGRMKCLKYWPDLApGVSADDLRADELPKLQLGPYVVffkerheHKLWTQRVFELEHEGEGRMtVTQFHMTAWPDHGVPSEPSDLLYFRQAIRAAF
.|.|. . || .||||    |.  ..|     .  |  | |        |.  |.. .  .| . |. |.|||.|.||| |||.||  .| . .....  
elkerkeekcaqywPdeG.lvtyGnirvevedetvlvdytv.......rkflvqqlpdatrekksrl.vrqfhftswPdvGvPfepiGmlkllkkvkkln

PNPTSPMLVHCSAGVGRSGTFIAIDHMLQLILDEaraasDVPDVRDVVHGMRDRRNFMVQTEEQYIFIYFALEM-ALTAMQATDKADLKMALDEFH
.. ..|. |||||||||.||||..| .|. .  |      . || ..|. .| .|  ||||.||| ||| .|    | .    | . |.  |....
qqsagpivvhcsaGvGrtGtfivldavlervkae.....rkvdvfefvkrlrlqrpqmvqtdeqyefiykvlleyylygdteldvsslekhlqkly

subfamily_PTPN12_pd Subfamily PTPN12 1230-1488 6.7e-68 223.7 In-house 31-275 (290) alignment
Range on Protein: 1230-1488
Range on HMM: 31-275/290.0
RHKSCATQANRDKNRYRNITAYDHSRVVLQVNPEEGGCDYYNANYIAGARSPSDYIACQGPTNSSVDDFWRMVWQQKTQCIVMVTNLEEQGRMKCLKYWP
. ..  .. |. ||||..|  ||.|||.|. . || | || |||.| |. ..  ||| |||    .||||||.|..... .||. .. | |..|| .|||
steagekeenvkknrykDilPydksrvelskieeeegsdYinanfikgvegkleyiaaqgPLpktlddfWrmiweknveivvmaCrevelgkkkCerYWp

DLApgvsADdlradelpKLQLGPYVV-FFKERHEHKLWTQRVFELEHEGEGRmTVTQFHMTAWPDHGVPSEPSDLLYFRQAIRAAFPNPTSPMLVHCSAG
.       .        .|. |.. |   .|.. .. .. | ...|...| | .|.||| |||||||||| ...|| . ...|    .  .|..||||||
eeg....ee........elefgefevtleeekavdddflirtLkveaqkesr.kvyqfhYtaWPDhgvPssaksllelielvrelqesedaPlvvhCsaG

VGRSGTFIAIDHMLQLILDEAraASDVPDVRDVVHGMRDRRNFMVQTEEQYIFIYFALEM
||| || ||||.. .|. .|    ..  || |.|  .| .|. .|||.||| ..| |.. 
vGrtGtiiaidyvrellkaek..ipeeldvfdlvlelrkqraalvqtkeqyelvykavae

subfamily_PTPRK_pd Subfamily PTPRK 1199-1502 1.1e-66 219.9 In-house 5-290 (314) alignment
Range on Protein: 1199-1502
Range on HMM: 5-290/314.0
KVDAILQHLQSKLDAE-GGLQTEFSRLQSVglrHKSCATQANRDKNRYRNITAYDHSRVVLQVNPEEGGCDYYNANYIAGARSPSDYIACQGPTNSSVDD
.|. .||...    ||  |.. |.  |        ..  . ||.|||. .| |||.|||.|..  ..   || ||..| . . |. .|. ||| .. | |
rvadllqsiallkraegygfkeeyeslfeg...wdaakkdenreknrsgdilaydrsrvflitidgdpssdyinaalidsykrpaafivtqgPlqetvkd

FWRMVWQQKTQCIVMVTNLEEQGRMKCLKYWPDLAPGvsADDLRadelpklqlgpyvVFFKERHEHKLWTQRVFELEH---EGEGRMTVTQFHMTAWPDH
|||.|..... .|||.|.| |.||.|||||||. .     .|..             | . | . ..   .|.| .|.     |.. .| ||. ..||||
fWrlvydencasivmltelvevgrvkClkyWPedtev..ygdik.............velvetellaelvvrifrveklargqeeirevrqfqflgWpdh

GVPSEPSDLLYFRQAIRAAFPNPTSPMLVHCSAGVGRSGTFIAIDHMLQLILDEaraasDVPDVRDVVHGMRDRRNFMVQTEEQYIFIYF-ALEMALTAM
.|| .   || . . . .  ..   ...|||||| ||.||||||| .|..|  |     .| ||  .|. .|.|.  ||.|||||.|||  .|| .|   
dvPvsatgllklvrrvkksqeeeaGrivvhCsaGaGrtGtfiaidivldmiere.....gvvdvfnavktlrsrkvnmveteeqykfiydvileaclcge

QATDKADLK
 |   ...|
taipvsefk

subfamily_Ptp69D_pd Subfamily Ptp69D 1209-1490 2.7e-66 218.8 In-house 16-286 (307) alignment
Range on Protein: 1209-1490
Range on HMM: 16-286/307.0
SKLDAEGGLQTEFSRLQ--SVGLRHKSCATQANRDKNRYRNITAYDHSRVVLQVNPEEGGCDYYNANYIAGARSPSDYIACQGPTNSSVDDFWRMVWQQK
.| |.. ||. |. .|.   . .  |  . . |  |||| .|.|.|. ||.|.. . .   || ||..| | .   ..|| |.| .. ..|||||...|.
rkrdtdfglakeyekLeareidkstkvsekkenalknRyedikafDktRvkLkkingkedsdYinasfikgykekkkfiaaqdPveatigDfWRmiaeqe

TQCIVMVTNLEEQGRMKCLKYWP-DlapgvsaddlradelPKLQLGPYVVFFKERHEHKLWTQRVFELEHEG------EGRMTVTQFHMTAWPDHGVPSE
 . |||..||.|. | || |||| .                . | |  .| . . ..|. ...| ... . .      | .  |.|.| |.|.|  ||  
vtlivmlsnlteknrkkcakYWpie...............devqygdilvklvseekhsdyiiReldvskkkeesgevedsrkvvqyhytgWkDskvPev

PSDLLYFRQAIRAAFPNPTSPMLVHCSAGVGRSGTFIAIDHMLQLILDEARAasdvpDVRDVVHGMRDRRNFMVQTEEQYIFIYFALEMAL
.  || . . .|    .  ||..|||||||||||.|.|.| .|| .  | ..     |. ..|...| .||..||  |||.|.| ||    
argllklieqvrelyklnrsPivvhCsaGvgrsgifvaldsllqqlkaedkv.....difetvkdLrsqRnllvqsleqYvflyralldys

subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 1204-1494 1.1e-63 210.2 In-house 10-287 (305) alignment
Range on Protein: 1204-1494
Range on HMM: 10-287/305.0
LQHL-QSKLDAEGGLQTEFSRLQSVGLRHKSCATQANRDKNRYRNITAYDHSRVVLQVNPEEGGCDYYNANYIAGARSPSDYIACQGPTNSSVDDFWRMV
 ... ... . . ||....  |.. .   .   ..||. |||...|| .|..|. |. .....  || ||.|. | ..   ||. ||| .. |.||||..
aayikearvysdkgleaqykslyeeeesidvgkkeankaknrlkeitlldddriiltekeslddsdyinasyvdgykrkkkyivaqgPlkntvadfWrli

WQQKTQCIVMVTNLEEQGRMKCLKYWPDlapgvsaddlR--AdelpKLQLGPYVVFFKERHEHKLWTQRVFELEH--EGEGRMTVTQFHMTAWPDHGVPS
.. |.. |||.|.| |.|. || .|||.          .       | ..|...|  |.... . ...| ...    | .   ||.|...| ||||||| 
veekvstivmltklveggkdkCrqYWpe..........skte....kkefgefsvelksektasdyieRklkisiededkesrtvlqyqltdWPdhGvpq

EPSDLLYFRQAIRAAFPNPTS-PMLVHCSAGVGRSGTFIAIDHMLQLILDEaraasDVPDVRDVVHGMRDRRNFMVQTEEQYIFIYFALEMALTAMQ
... || . . .. .  .    |.||||||||||.|.|||.| .|. .  |     .| || .|.. .| .|  |||| .|| |.. ||.  .|. .
fatsllslikrvqkdqkkdkgvpllVhCsagvgRtGvfiavdialerlkkE.....evvdvfevlkqlRskrmkmvqtldqYvflhdaldelitcgd

subfamily_PTPN13_pd Subfamily PTPN13 1206-1492 1.7e-63 209.5 In-house 3-271 (273) alignment
Range on Protein: 1206-1492
Range on HMM: 3-271/273.0
HLQSKLDAeGGLQTEFSRLQSVGLRHKSC--ATQANRDKNRYRNITAYDHSRVVLQvnpEEGGcdYYNANYIAG--ARSPSDYIACQGPTNSSVDDFWRM
 ||.|||  .  . ||  |. .    ..    ...|.|||||||.  ||..|| |.   .|||  | ||..|         .|||||||   .|.|||.|
alqkkldq.qqPaeefkelrelkpldtcevgkkkenkdknryrnvlPydetrvklg...degg..yinaslikvpvgkdeyeyiacqGPlPetvkdfwqm

VWQQKTQCIVMVTNLEEQGRMKCLKYWPDLApgvsADDLRADELPKLQLgpyvvffKERHEHKLWTQRVFELEHEGEG-RMTVTQFHMTAWPDHGVPSEP
||.||.. |.|||.  |.|..|| .|||. .     . | . .  ...|        .  ... ...| .....   |    |.......||||||||..
vweqkaeviamvtlekekgkvkchrywPesk....nkklkvsnrlevel.......lkvqkldgfvvralavkdsesgesrevahlnfvkwPdhgvPssa

SDLLYFRQAIRAaFPNPTSPMLVHCSAGVGRSGTFIAIDHMLQLILDEAraasdVPDVRDVVHGMRDRRNFMVQTEEQYIFIYFALEMALTA
 .|| | . .|  . . ..|..||||||.|||||.|.|| .|.||  .        ||...|. .|..|. .|||..||||.| |.  .|. 
aellqfvaevrr.lqtdagPivvhcsaGiGrsGtlitidvvlglierdk.....efdvkeivrklreqrqgvvqtkdqyifvykailevlks

subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 1237-1494 3.2e-63 208.2 In-house 7-246 (250) alignment
Range on Protein: 1237-1494
Range on HMM: 7-246/250.0
QANRDKNRYRNITAYDHSRVVLQVNPEEGGCDYYNANYIAGARSPSDYIACQGPTNSSVDDFWRMVWQQKTQCIVMVTNLEEQGRMkCLKYWPdlapgvs
 .|..|||| .| |.|.|||||. .  .  .|| || .. | .  . .|| ||| .... ||||||...|.. |||.|||.|...  . .|||       
pqnkeknryadiialdssrvvLekekgdkesdyinasflhgyderkafiatqgPlqatiedfWrmvleeksgtivmLtnLkesekt.yhqywP.......

ADDlrADelpklQLGPYVVFFKERHEHKLWTQRVFELEHEGEGR-MTVTQFHMTAWPDHGVPSEPSDLLYFRQAIRAAFPN-PTSPMLVHCSAGVGRSGT
..   |.     . |   |  ....|.  .|.|.. | .. .    .| |.| ..||| ||| .    | ... ..|  ..  ..|..|.|||||||||.
vek..ae.....kyGdvtvsllskeefadytkrklklskakkaderivrqlhfvvWPdkgvPevatavLellkkvqasqqqagnaPvivqCsaGvgrsGa

FIAIDHMLqlilDEARAaSDVPDVRDVVHGMRDRRNFMVQTEEQYIFIYFALEMALTAMQ
||||| .|    . ..  . | ||..|.. .|  |  .|...|||.|.| ..  ||....
fiaidavl....erlkk.ekvvdvfkvikvlrkdrphavesleqyvfvyeiilkaldsve

subfamily_PTPN3_pd Subfamily PTPN3 1215-1483 1.4e-62 206.1 In-house 15-268 (280) alignment
Range on Protein: 1215-1483
Range on HMM: 15-268/280.0
GGLQTEFSRL--QSVGLRHKSCATQANRDKNRYRNITAYDHSRVVLQVNPEeggcDYYNANYIA----GARSPSDYIACQGPTNSSVDDFWRMVWQQKTQ
| . ..| .|  .  ||  . .   .| .|||||.|..||. || |. ..     || ||||.     ..     |||.||| .... |||.|||.||..
Gavlaqfeqlyrkkpglaisaarkpenlsknryrdilpydatrvklkeset....dyinanyvnmeipstglvnryiatqGPlaktatdfWqmvweqkss

CIVMVTNLEEQGRMKCLKYWPDLApgvsaDdlradelpKLQLGPYVVFFKERHEHKLWTQRVFELEHEG-EGRMTVTQFHMTAWPDHGVPSEPSDLLYFR
 |||.|.| |.||.|| .|||.       |        .|..| . |  ....|.| .  | . |...  . . ...|.  .||||||||....|.| | 
livmlttlverGrvkChqyWPete.....d........eleygefsvkcekedetksyvlrelvlkdketkeerkilqlqylaWpdhgvPddsadflefv

QAIRAAFPNPTSPMLVHCSAGVGRSGTFIAIDHMLQLIldEARAASdvpDVRDVVHGMRDRRNFMVQTEEQYIFIY
. .|..    ..|..||||||.||.| .|...  |.||  ||. .     . |.|. |||.|  .|||..|| |. 
ervrklrsgkeePvvvhCsaGigrtGvlilletalali..eaaepv...ypldivrtmrdqramlvqtasqykfvC

subfamily_PTPN9_pd Subfamily PTPN9 1214-1490 1.8e-62 206.1 In-house 15-291 (297) alignment
Range on Protein: 1214-1490
Range on HMM: 15-291/297.0
EGGLQTEFSRLQSVGL--RHKSCATQANRDKNRYRNITAYDHSRVVLQVNPEEGGCDYYNANYIAGARSPSDYIACQGPTNSSVDDFWRMVWQQKTQCIV
. ||. |.  ...     . .   ..||  |||| ..  ||..||||.  .|.   || |||.. | . .  .|| ||| .  |.|||||||.|..  ||
krGlskeyaeirnepveGtflasklranleknrytdvlcydetrvvlakvdedeasdyinanfvdGykqkkafiatqGplkktvsdfWrmvWeqevlviv

MVTNLEEQGRMKCLKYWPDlapgvsaD-DlRadelpKLQLGPYVVFFKERHEHKLWTQRVFELEHEGE-GRMTVTQFHMTAWPDHGVPSEPSDLLYFRQA
|.| ..|.||.|| .|||.       . .         . | . |   | .|.. ...||.|...  .    .|| | ...|||.||||. ..|| ....
mttrvvergrlkcgqyWpl.......eee.s.....saefgdlsvsnveveeeedykvrvleiknvkteesrkvthfqflsWPdyGvPssaaslldvlek

IRA-------------AFPNPTSPMLVHCSAGVGRSGTFIAIDHMLQLILDEARAasdvpDVRDVVHGMRDRRNFMVQTEEQYIFIYFAL-EMAL
.|              ...    |..||||||.||.||||..|  |. . ... .     ||...|. .| .| |..||.||| | |.|. | ||
vrekqalavkelgdewkghpsgPPivvhcsaGiGrtGtfitldiclsrleevgtv.....dvvetvkllrtqrafsiqtpeqyefcylavleyal

subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 1230-1490 3.4e-62 205.1 In-house 35-277 (315) alignment
Range on Protein: 1230-1490
Range on HMM: 35-277/315.0
RHKSCATQANRDKNRYRNITAYDHSRVVLQVNPEEGGCDYYNANYIAGARSPSDYIACQGPTNSSVDDFWRMVWQQKTQCIVMVTNLEEQGRMKCLKYWP
|.... .. |  ||||.||  .|..||.|.|  ..   ||.|| || .  .   ||| ||| ..|||||||||.|.|.  |||||...|. ..|| .|||
rqrvaretinfkknryknilPldsarvkleviddsPdsdyinasyiksvdddkayiasqgPlkasvddfwrmvlqekvttivmvtkkqegdkikcrqywP

DlapgvsaddLRADelpKLQLGPYVVFFKERHEHKLWTQRVFeLEHEGEGRMTVTQFHMTAWPDHGVPSEPSDLLYFRQAIRAAFPNPTSPMLVHCSAGV
|          .||     ..| . |   . .     ..| .    ..|   |||||..| |||.||. . | || . ....|   . . ..||||||||
d.........rkad...svefGsikvellsleadtdgvarkl.vtrkseesrtvtqfqftewPdkGvdkqtssllklikevkadngkkefsllvhcsaGv

GRSGTFIAIDHMLQLIldeaRAaSDVPDVRDVVHGMRDRRNFMVQTEEQYIFIYFALEMAL
||.| .|.||.... |    .  ... || ..|. .|. | ..|||||.| ||| |.   |
GrtGvvisidevvaqi....kr.trsvdvfnfvknlrakrpylvqteeeyafiydavledl

subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 1237-1487 3.8e-62 205.0 In-house 41-273 (515) alignment
Range on Protein: 1237-1487
Range on HMM: 41-273/515.0
QANRDKNRYRNITAYDHSRVVLQVNPEEGGCDYYNANYIAGARSPSDYIACQGPTNSSVDDFWRMVWQQKTQCIVMVTNLEEQGRMKCLKYWPDLaPGVS
. |  ||||.||  || .|| |.|  ..   ||.|| || .  .   ||| ||| ..|||||||.|.|...  |.|||.|.|. ..|| |||||  || |
einfkknryknilPydsvrvklevindnPhsdyfnasyipsfdndkayiasqgPnkasvddfWrlvlqenvttiamvtklkegdkikcgkyWPdk.pgds

addlradelpkLQLGPYVVFFKERHEHKLWTQRVFELEHEGEgRMTVTQFHMTAWPDHGVPSEPSDLLYFRQAIRAAFPNPTSPMLVHCSAGVGRSGTFI
           ...| . |     .     ..| ... .. .   ||||||.| |||.||| . | || . ....|   . | |...|||||||| | .|
...........vkfGsikvelvsleactggikrkltvlkgdd.srtvtqfhfteWPdkGvpkhtssllklikevkadhgqythpliihcsaGvGrtGvvi

AIDHMLQLIldearAASDVPDVRDVVHGMRDRRNFMVQTEEQYIFIYFALE
.|| ..  .     . ... || ..|. .|..| ..|||.||| ||| |. 
sidsvvaha.....kttrmvdvfnfvtnirqkrpylvqtqeqyafiygavl

subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 1237-1488 4.6e-62 204.4 In-house 18-262 (270) alignment
Range on Protein: 1237-1488
Range on HMM: 18-262/270.0
QANRDKNRYRNITAYDHSRVVLQVNPEEGGCDYYNANYIAGAR-SPSDYIACQGPTNSSVDDFWRMVWQQKTQCIVMVTNLEEQGRMKCLKYWPDlapgv
  ..  |||..|    ..||.|.   |.    |.||||..|.  ..  ||| .||..... .||||.|..|...|||.|.|||.|| || .|||      
argkklnRyadiLPsPatRvrleeleedsataYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkgrkkCerYWpa.....

saddlRADELPKLQLGPYVVFFKERHEHKLWTQRVFELEHEGEGRMTVtQFHMTAWPDHGVPSEPS------DLLYFRQAIRAAFPNP--TSPMLVHCSA
     ...|  ||. |   |.  . . .. . ..  .||..|| |  |  |....|||||||.|.       .||.  .|.|.   .   ..|.||||||
.....epkekvkledgkikvlalseekeegyiltrlrleekgeerrlv.HfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkaePllvHcsa

GVGRSGTFIAIDHMLQLILDEARAasdvpDVRDVVHGMRDRRNFMVQTEEQYIFIYFALEM
||||.||.||.|....|.  . ..     ||  ... .|  |  .||. ||| |.| |. .
GvgRtGtlialDiavrlLeetkkv.....dvlaiieelRkdRmalvqhpeqyeflykavve

subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 1208-1489 5.1e-61 201.3 In-house 17-278 (315) alignment
Range on Protein: 1208-1489
Range on HMM: 17-278/315.0
QSKLDAEGGLQTEFSRLQSVGLRHKSCAT-QANRDKNRYRNITAYDHSRVVLQVNPEEGGCDYYNANYIAGARSPSDYIACQGPTNSSVDDFWRMVWQQK
| |  .. |.. ..  .    |.    |    |..|||| || |||.||| | .   . ..|| |||.| |   .  |||.|||  .||.||||.|....
qkkastkngfkqdyesipggqlhpldvakkienkqknryiniiaydksrvqlpllendphsdyvnanfidGynkkrryiaaqgpnvasvkdfwrlvfeed

TQCIVMVTNLEEQGRMKCLKYWPDLapgvsaddlradelpKLQLGPYVVFFKERHEHKLWTQRVFELEHeGEGRMTVTQFHMTAWPDHGVPSEPSDLLYF
   |||.||| |. . |. |||||                |.  |.. |  |.   .. .| | .     |.   .| |.|.|.||| |||     |. .
igkivmltnlvegekrkaekywpdk...............kviyGkitvtrkseevnteytvrtlsvvf.gdnirevvqlhytswpdmgvpkytiplmnl

RQAIRAAFPNPTSPMLVHCSAGVGRSGTFIAIDHMLqlilDEARAaSDVPDVRDVVHGMRDRRNFMVQTEEQYIFIYFALEMA
 . ..    |  ....|||||||||.||||..| .|    |.| |  .. || ....|.|. |  |||. ||| ||| ||  .
irtvkqhhtnsvgaivvhcsaGvGrtGtfitldavl....dqaea.enaidvynfitgvrqnrikmvqvaeqyqfiydallet

subfamily_PTPN1_pd Subfamily PTPN1 1228-1486 2.6e-58 192.0 In-house 21-267 (290) alignment
Range on Protein: 1228-1486
Range on HMM: 21-267/290.0
GLRHKSCATQANRDKNRYRNITAYDHSRVVLQVNPEeggcDYYNANYIAGARSPSDYIACQGPTNSSVDDFWRMVWQQKTQCIVMVTNLEEQGRMKCLKY
 ...... ...||..||||... |||||..|. .      || ||. .   .    ||  |||  . || ||.|||.||....||. .. |....|| .|
dfptreaklpenrnlnryrdvspydhsrikleradn....dyinaslveleeakrsyiltqGPlpntvdhfWqmvWeqkskavvmlnkvvekeqikcaqy

WPDLAPgvsaddlrADELpKLQLGPYVVFFKERHEHKLWTQRVFELEH-EGEGRMTVTQFHMTAWPDHGVPSEPSDLLYFRQAIRAA--FPNPTSPMLVH
||             .|| .|.   . | . ...... .| |..|||  . .   ....|| |.||| |||. |. .| | . .| .  . .   | ..|
wPqgee........ekel.lledtklkvkliseerksyytvrllelenlktqetreilhfhyttwpdfgvpespaaflkflfkvresGslssdvGpavih

CSAGVGRSGTFIAIDHMLQLIldEARAASDVPDVRDVVHGMRDRRNFMVQTEEQYIFIYFAL
||||.||||||. .| .| ||  |..   .  |...|.  .|  |  ..|| .|  | |.|.
csaGiGrsGtfclvdtclvli..ekkddlssvdikkvllelrkyrlGliqtadqlrfsylai

subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 1216-1487 3.4e-58 192.4 In-house 35-288 (319) alignment
Range on Protein: 1216-1487
Range on HMM: 35-288/319.0
GLQTEFSRLQSVGLR---HKSCATQANRDKNRYRNITAYDHSRVVLQVNPEEGGCDYYNANYIAGARSPSDYIACQGPTNSSVDDFWRMVWQQKTQCIVM
 |. || |.  .|      . .  . |.||||. || |.|...| |.    | . || || ...| ...  |||.||| . ...|||||.|....  ||.
klevefrracklgvnladqtfanldqnkdknriinilafdknvvklerliGeefsdyinasfvtGyqrkdkyiaaqGPldntladfWrmiweyncstivl

VTnleeqgRMKCLKYWPDlaPGVSaddlrADELPKLQlgpyVVFFKERHEhklWTQRVFELEHEG--EGRMTVTQFHMTAWPDHGVPSEPSDLLYFRQAI
.|      . || .|||    .|       .|  |..    |   .| .|   .. | .|| ..|  ..   .||||.  |||.|||  ||||. . . .
lt......kdkcsqywpl..kivi.....keerfkvk....vdsveetae...yvvrdielsedgkekdirkitqfhflGwpdvGvpdypsdlmrlvkkv

RA--AFPNPTSPMLVHCSAGVGRSGTFIAIDHMLQLILDEARAasdvpDVRDVVHGMRDRRNFMVQTEEQYIFIYFALE
|      |   ...|||||||||.|..|..| .|. . .| .      || ..|...|..|| .||   || ||| || 
rhltskenhranivvhcsaGvGrtGvyivldvlldrmkeekqv.....dvynfvrdlrqqrntlvqdlvqykfiysall

subfamily_PTPN23_pd Subfamily PTPN23 1207-1488 2.3e-57 189.0 In-house 7-279 (288) alignment
Range on Protein: 1207-1488
Range on HMM: 7-279/288.0
LQSKLDAEGGLQTEFSRLQSVG---LRHKSCA-TQANRDKNRYRNITAYDHSRVVLQvnpeEGGCDYYNANYIAGARSPS-DYIACQGPTNSSVDDFWRM
 ...|| ...|...|  |..      |..|.|  . . .|||.|.|  |||.||.|.    ..  || || .. .  . . |.|| |.| .|.. |||.|
qrkmldgktaldkkfkeleqkqdkearkrsiaiaklyseknrsrdilPyDhnRvklr....gskDDYinAsfvkdlspgcPdfiatqaPlqstlnDFWlm

VWQQKTQCIVMVTNLEEQGRMKCLKYWPDLA-PGVSADDlradelpklqlgpYVVFFKERHEHKLWTQRVFELEHEGEGRM-TVTQFHMTAWPDHGVPSE
|..||.. |||... ||.|. |. .|||      |. .|             . |  |. .| . . .||..||.... .. .|.  ..|.||..|||. 
vyeqkssviVmllskeelgkpkvdrYwPedkgetvkfgd.............lsvtlksvretethvervlkletldadavksvshlqltsWpelGvPas

PSDLLYFRQAIRAAFP----NPTSPMLVHCSAGVGRSGTFIAIDHMLQLIldeaRAASDVPDVRDVVHGMRDRRNFMVQTEEQYIFIYFA-LEM
|..|| | .....|.     .   |..|||||||||.|.|  .   .. .    ..   ..|. .||. .|  | ||||..||. | | | || 
PetllqfldevesayeavqrksktPlvvhCsaGvgRtgvfalvyaavrel....ekgnglldiiqvvsrlreqRrfmvqekeqlkfsyeavlea

subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 1235-1487 5.6e-57 188.4 In-house 21-252 (284) alignment
Range on Protein: 1235-1487
Range on HMM: 21-252/284.0
ATQANRDKNRYRNITAYDHSRVVLQVNPEEGGCDYYNANYIAGARSPSDYIACQGPTNSSVDDFWRMVWQQKTQCIVMVTnleeqgRMKCLKYWPDLApg
  . |.||||. .| |.|...| |.    | . || || .|.| ...  |||.||| . ...|||||.|....  ||..|      . || .|||  .  
nldqnkdknrighilafdknvvklerliGeefsdyinasfitGyqrkdkyiatqGPldntladfWrmiweyncstivllt......kdkcsqywplki..

vsadDlRADELPKLQlgpyVVFFKERHEhklWTQRVFELEHEG--EGRMTVTQFHMTAWPDHGVPSEPSDLLYFRQAIRA--AFPNPTSPMLVHCSAGVG
    .   .|  |..    |   .| .|   .. | .|| ..|  ..  ...|||.  |||.|||  ||||. . . .|      |  ....||||||||
....v.ikeerfkvk....vdsveesee...yvvrdielsedgkekdirkirqfhflgwpdvgvpdypsdlmrlvkkvrhltskenhranivvhcsagvg

RSGTFIAIDHMLQLILDEARAasdvpDVRDVVHGMRDRRNFMVQTEEQYIFIYFALE
|.|..|..| .|. . .| .      || ..|...|..|| .||   || ||| || 
rtgvyivldvlldrmkeekqv.....dvynfvrdlrqqrntlvqdlvqykfiysall

subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 1218-1488 8e-57 187.4 In-house 8-266 (274) alignment
Range on Protein: 1218-1488
Range on HMM: 8-266/274.0
QTEFSRLQSVGlRHKSCATQANRDKNRYRNITAYDHSRVVLQV-NPEEGGCDYYNANYIAGARSPS-DYIACQGPTNSSVDDFWRMVWQQKTQCIVMVTN
..||  | .    ..      .  ||||..|   ..|||.|.  ..|.   .| ||||| | .  |  |.| |||  . |.|||||..|...| |||.|.
ekeflelPlnf.dqeeldvfgsqtknryktilPnensrvllesessededssyinanyikGydeeskayvatqGPlpntvadfWrmiyqeevqvivmltk

LEEQGRMKCLKYWPDLAPG-VSADDLRADelpklqlgpyvVFFKERHEHKLWTQRVFELEHEGEgRMTVTQFHMTAWPDHGVPSEPSDLLYFRQAIRA--
|.|. . || .|.||     .|      .           . ...  |.. .. | . |..  . . .|. .  |.|||| .| ... || . . ..   
lkeaneqkCavyfPdaedyeiserygdve...........ikvekiverndysvrklvlkyler.ersvkhywytdWPdhksPddantlldlvleveesr

-AFPNPTSPMLVHCSAGVGRSGTFIAIDHMLQLILDearaaSDVPDVRDVVHGMRDRRNFMVQTEEQYIFIYFALEM
 .  ....|..||||||.|| | ||||.  .. . .     . | ||  .|  .|  |  ||||.||| .|. || .
eeenaklapvvvhCsaGiGrtGcfiaisiavrqlre.....eivvdvlkivcnlrldrGGmvqtseqyelihralcl

subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 1239-1484 2.1e-56 185.8 In-house 3-233 (237) alignment
Range on Protein: 1239-1484
Range on HMM: 3-233/237.0
NRDKNRYRNITAYDHSRVVLQVNpeEGGCDYYNANYIAGA-RSPSDYIACQGPTNSSVDDFWRMVWQQKTQCIVMVTNLEEQGRMKCLKYWPDlapgvsA
|. |||| ||.|||||||||. .   .|.|| ||.|. |   .|  |||.||| .|| ||||.||||.|   |||.| | |. ..|| ||||.      .
nkiknrygnivaydhsrvvlkga..gsgsdyinatylkgfdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywps......t

DDlradelPKlQLGPYVVFFKERHEHKLWTQRVFELEHEGE--GRMTVTQFHMTAWPDHGVPSEPSDLLYFRQAIRAAFPN--PTSPMLVHCSAGVGRSG
|.      |.   | . | .| . |   .| | . | ....  .   . |...|.|||.||| . . || ||. |    |    ..| ..||||||||.|
dq......pa.aygvltvslkkkeefsdytvrslllskrltlkevrlihqyqftswpdrgvpqqtaallrfrkniinrsphvsesgpwiihcsagvgrtg

TFIAIDHMLQlildEARAaSDVPDVRDVVHGMRDRRNFMVQTEEQYIFIYF
 |. || ||.    .|.    | |. . |. . . | ...||..||.||. 
iflvidamlr....qake.kkvvdiynyvysieedrpyiiqtkdqyvfihq

subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 1204-1490 2.3e-56 186.3 In-house 11-288 (325) alignment
Range on Protein: 1204-1490
Range on HMM: 11-288/325.0
LQHLQS-KLDAEGGLQTEFSRLQSVGLRHKSCAT-QANRDKNRYRNITAYDHSRVVLQVNPEEGGCDYYNANYIAGARSPSDYIACQGPTNSSVDDFWRM
..|..  | . . |.  ||  | |..   |  |.  .|..|||..|. |.|.|||||.   ... .||.||.|.   .    ..|.| |  ....|.||.
vehvekkkaqdqdgfahefgllpsddgiakkvamkpenkaknrfknvvaldksrvvletkkddpssdyinasylrddkkkdvflaaqaPltatindlWrl

V--WQqktQCIVMVTNLEEQGRMKCLKYWPDLApGVSaddlradelpkLQLGPYVVFFKERHEHKLWTQRVFELEHEGEG-RMTVTQFHMTAWPDHGVPS
|  |.     .|.|.|  ..|  .| .|||.   | |            ..|.  | ..   |   . .||...    .|  ..| ||.. .|.| ||. 
vldWr...csvvvvlneldlgkdrcavywpkem.gks...........ktfGglevklrtieeisdyvhrvldvkqvkkGetrsvkqfqlqswddmGvqk

EPSDLLYFRQAIRAAFP------NPTSPMLVHCSAGVGRSGTFIAIDHMLQLILDEARAasdvpDVRDVVHGMRDRRNFMVQTEEQYIFIYFALEMAL
 |. |. . | . |         . ..|.||||||||||.|.||..  .|. ...|.|      |. ..|. .|  |  ||.| .|||.|| ||  |.
rpatlisilqlvkavservtantkastpilvhcsaGvGrtGvfislysalakvieesrv.....difgfvkklrkdrpsmvetvdqyiliyealveay

subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 1235-1494 4.8e-56 185.1 In-house 46-288 (297) alignment
Range on Protein: 1235-1494
Range on HMM: 46-288/297.0
A-TQANRDKNRYRNITAYDHSRVVLQVNPEEGGCDYYNANYIAGARSpsDYIACQGPTNSSVDDFWRMVWQQKTQCIVMVTNLEEQGRmKCLKYWPDLAp
|  . | .|.||.||  || ||| |..  ..   || || .. | .    .|. | | ...|.|||.||...... |||.....|. . || .||.| . 
aekkvnfeksRYkniLPydssRvkLaivnddpdsDyvnasfvkgnkh..rlittqmPmkatvadfWamvldeqvstivmlnddnerdk.kcaryWsdkg.

gVSAddlradelpklqLGPYVVFFKERHEHKLWTQRVFELEHEG-EGRMTVTQFHMTAWPDHGVPS--EPSDLLYFRQAIRAAFPNPTS-PMLVHCSAGV
 |..            .|  .|  .  .| .   .| .|....    |  | |.. . |||. |.   . | || . . .|  | . .. |.||||.|||
.vtt............fGdvsvvllsvsereGfikrelevtkgkakarrvvkqyqfveWPdkaverkdsassllklisevrkdfsqnaegPllvhclaGv

GRSGTFIAIDHMLQlildEARAASDVpDVRDVVHGMRDRRNFMVQTEEQYIFIYFALEMALTAMQ
|| | ...|| ..     ||.   .| |. ..|. .|. | ..|||.||| |.| |.  || . .
Grtgvlltidsvva....eakrekev.difglvkklrqerpylvqtkeqykfvyvavleallsed

subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 1214-1494 1.9e-55 182.9 In-house 19-282 (287) alignment
Range on Protein: 1214-1494
Range on HMM: 19-282/287.0
EGGLQTEFSRLQSVGLRHKSCA---TQANRDKNRYRNITAYDHSRVVLQvnpeEGGCDYYNANYIAGARSPSDYIACQGPTNSSVDDFWRMVWQQKTQCI
. | .. |  |..|. |...     .. |.||||...|  .|  ||.|.    .   || || .| | ..   .|....|  . . .||....... . |
negfknqftvleqvtqredevthniasqnkdknRltqilvpdnyrvllk....gehpdyinavfidgykekkafiiaesPmfntarnfWkliddrnvtai

VMVTNLEEQGRMKCLKYWPDlapgvsADdlradelpKLQLGPYVVFFKERHEHKLWTQRVFELEHEG--EGRMTVTQFHMTAWPDHG-VPSEPSDLLYFR
||.....|. . .| .|||.       .         . ||.| . . ... .. ...| .|.....  . . .|.|...|.|...| |..  . || . 
vmlcqekendeevcyqyWpe......ek........svvlGeyniellneevnagyierklevknknkagdkqqvkqyqitnWdstgkvtepqtillvie

QAIRAAFPNPTSPMLVHCSAGVGRSGTFIAIDHMLQLILDEAraasdVPDVRDVVHGMRDRRNFMVQTEEQYIFIYFALEMALTAMQ
. ...   .  ....||||..||||..|.|..  ..    |      | || .|.. .| ..  .||| |||.||. .. . |....
emyktqrkrgntsivvhCsdtvGrsamfcaaattinkckteG.....viDvfqvlksqriqkpgsvqtveqykfindivleyldsfe

subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 1211-1493 5.8e-55 181.2 In-house 16-286 (290) alignment
Range on Protein: 1211-1493
Range on HMM: 16-286/290.0
LDAEGGLQTEFSRLQSVGLRHKS--CATQANRDKNRYRNITAYDHSRVVLQVNPEEGGC--DYYNANYIAGARSPSDYIACQGPTNSSVDDFWRMVWQQK
   . | ...| .|.|    |.     |. |. .||..||  ||  |..|.  ...  |  .| || || | .   .||| |||... . |||...||.|
akgnegfrnqfkmldsgesehtvtvgltssnkllnRfanivvyddnritLrpisghkDCtneyinAcyikgykekkqyiatqgpvsntlvdFWkliwqek

TQCIVMVTNLEEQGRMKCLKYWPDLAPGVsADDLRADElpklqlgpyvvffKERHEHKLWTQRVFELEHEGE--GRMTVTQFHMTAWPDHG-VPSEPSDL
. .|||.||  |.|. || .||||       .  .                 . ....  ..| .|.... .   . .|||...|.|...| |. . . |
vtiivmltniieegkvkCqqYWpdsdtka.ygefsikl.............lneetlneyierklevknknsagakqsvtqyqitnwdstgkvtnpqtil

LYFRQAIRAAFPNPTSPMLVHCSAGVGRSGTFIAIDHMLQLILDEaraasDVPDVRDVVHGMRDRRNFMVQTEEQYIFIYFALEMALTAM
| ... ..  . .   ...||||..||||..|.|..  ..    |      | || .|.. .|  .  .|||..|| .|.  .  .|. .
lvieemyktqrkrgntsivvHCSdtvgrsavfcaaattinkckte.....gvidvfqvlksqRiqkpgsvqtvqqyqgifqivltyldsf

subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 1231-1486 1.2e-54 180.2 In-house 37-232 (392) alignment
Range on Protein: 1231-1486
Range on HMM: 37-232/392.0
HKSCATQANRDKNRYRNITAYDHSRVVLQVNPEEGGCDYYNANYIAGARSPSDYIACQGPTNSSVDDFWRMVWQQKTQCIVMVTNLEEQGrmkclkywpd
.... .. |  ||||.||  || .||.|.|  .    ||.|| || .  .   |||.|||  .|.|||||||.|...  |.|||.|.|            
qtvaqkeinlkknryknilpydsarvkleviddipdsdylnasyipsfdnekayiasqgpnaaslddfwrmvfqenvttiamvtklkegd..........

lapgvsaddlradelpklqlgpyvvffkerhehklwtqrvfelehEGEGRMTVTQFHMTAWPDHGVPSEPSDLLYFRQAIRAAFPNPTSPMLVHCSAGVG
                                              |.   ||.|||.| |||..||   | || | . ..| | . | |...|||||||
.............................................kgddartvaqfhftewPdkdvpkhtssllkfikevkadfGqythpliihcsagvg

RSGTFIAIDHMLqlilDEARAASdVPDVRDVVHGMRDRRNFMVQTEEQYIFIYFAL
|.|  |.|| ..      |. .  . || ..|  .| .| .||||.||| ||| |.
rtgvvisidsvv....ahakktr.mvdvfnfvtnirrkrpymvqtkeqyafiygav

subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 1234-1487 2.6e-51 169.4 In-house 43-276 (439) alignment
Range on Protein: 1234-1487
Range on HMM: 43-276/439.0
CATQANRDKNRYRNITAYDHSRVVLQVNPEEGGCDYYNANYIAGARSPSDYIACQGPTNSSVDDFWRMVWQQKTQCIVMVTNLeeqgrMKCLKYWPDLAP
 | . .. ||||....|.||.||.||  |      |.||||| |   .  |||.|||.. ..|||||.|...||  |||.|||     ..  ||||  | 
aaqeydqtknrykdvgafdhtrvtlqeipgvphshyinanyikGyyddklyiatqgpkkettddfwrlviekktvtivmltnl.....vesykywpsdae

GVSAD-DLRADElpKLQLGPYVVffkerHehklwTQRVFELEHEGEGRMTVTQFHMTAWPDHGVPSEPSDLLYFRQAIRAAFP-NPTSPMLVHCSAGVGR
 .  |  .|.|   ...|  ||.     .       .||.    .|   || ||| .||||. ||.. | .| | .|| .|   . . |..|||||||||
vcygdiavrvdr..nielpnyvi.....r.....gfkvfnerdttekertvlqfhyiawpdknvpaqashvldflrainsandkeeygpvvvhcsagvGr

SGTFIAIDHMLQLILDEARAasdvpDVRDVVHGMRDRRNFMVQTEEQYIFIYFALE
.|| ||.|  |. .  | .      |.. .|. .|..|. |||.  ||.||| |. 
tGtiialdialeqlklenkv.....dikgivkvlrkqrkqmvqalcqyvfiynavl

subfamily_PTPN14_pd Subfamily PTPN14 1198-1486 3.4e-51 169.0 In-house 7-292 (300) alignment
Range on Protein: 1198-1486
Range on HMM: 7-292/300.0
EKVDAILQHLQSKLDaEGGLQTEFSRLQSVGLR--HKSCATQANRDKNRYRNITAYDHSRVVLQVNPEEgGCDYYNANYIAGA--RSPSDYIACQGPTNS
.  |.  ..|. ||. || . ||. |..   .    .... . | .|||....  |...|| |. . |.   .| ||  |  .   .  .||..||| . 
atkdkrakilekkle.egkvfteyeripkkredallstaklpenaeknrfkdvlPyednrvelsptken.stgyinassikvsvggkersyivaqgPlel

SVDDFWRMVWQQKTQCIVMVTNLEEQGRMKCLKYWPDLApgvsaddlraDELPKLQLGPYVVFFKERHEHKLWTQRVFELEHEGEG-RMTVTQFHMTAWP
 | |||.|||.|..| |||.|. ||.|. |..||.|.|           ..  ... | . |  | ... .  . . ..|.|   . . ||  .  | ||
tvqdfWqmvWeqgvqlivmlteeeedgkeksfkyfPkle..........skkktvefgkfkvttkfsedsdsvittglklkhlpskeertvwhlqytDWp

DHGVPSEPSDLLYFRQ---AIRAAFPNP------TSPMLVHCSAGVGRSGTFIAIDHMLQLIlDEaraaSDVPDVRDVVHGMRDRRNFMVQTEEQYIFIY
|||||..... | . .   ..| .. .         |.||||||||||.|  |  | ... . .      .. |.. |.. .| .| ..|||  || |.|
dhgvPeDvkgflsyLeevqsvrrktnseveskeskPPvlvhCsaGvGrtGvlilsdlliatl.eh....neeidikkvlarLreqrmllvqtlaqYkfvY

FAL
 .|
kvl

subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 1217-1493 3.4e-50 165.4 In-house 17-296 (301) alignment
Range on Protein: 1217-1493
Range on HMM: 17-296/301.0
LQTEFSRLQSVGLRHKS-CATQANRDKNRYRNITAYDHSRVVLQVNPEEGGC--DYYNANYIAGARSPSDYIACQGPTNSSVDDFWRMVWQQKTQCIVMV
.. ....|...  .. .   ...|.  ||..||| ||. |..|. .|.   |  .| ||.|| | ..   .|| ||| .. . ||||..||.|.. ||||
feeqykelkegedksctvglseenkalnrfknitvyddnriilkpkpnldlcqreyinasyidgysekkkfiaaqgpmkktlvdfWrliwqekpvsivmv

TNLEEQGRMKCLKYWPDLAPGVSADDLRA------DELPKLQLGPYVVFFKERHEHKlWTQRVFELEHEGeGRMTVTQFHMTAWPDHGVPSEPSDLL-YF
|||.|. . || .|||.     .              .|   .    |  ..  ...  ..| |. ...    ..|.|...| ||..||  ||   |   
tnlkegtkskceqywpnseaeseefgpftvtlvneqvyPdfvirqlnvkiqdgsnng.yierkfkvksdk.sswdvlqlqvtdWpqdGvvreprtvLqvi

RQAIRAAFPNPTSPMLVHCSAGVGRSGTFIAIDhmlqLILDEARaASDVPDVRDVVHGMRDRRNFMVQTEEQYIFIYFALEMALTAM
 . | .      .|..||||..|.|||......    . |. .. |  | || .|.. .|  .  .|.| |||..|| ...| |.  
ddvihrqqkigggpvvVHCSdtVsrsGvYcsvs....iglEQck.aegVVdvfqvtkavrrskpgaVtTLeqytsiydvidmylqln

subfamily_PTPRN_pd Subfamily PTPRN 1202-1486 8.5e-49 160.9 In-house 16-288 (297) alignment
Range on Protein: 1202-1486
Range on HMM: 16-288/297.0
AILQHLQSKLDAEGGLQTEFSRLQSVGLRHKSC---ATQANRDKNRYRNITAYDHSRVVLQVNPEEGGCDYYNANYIAGA--RSPsDYIACQGPTNSSVD
 .|..|. .|  .  |. |.  | .     ...    .. | .|||.... .|||||| |. . ..   || ||  |     |.|  |||.||| .|.| 
vvlsyledhlknkdrlekewealcayeaepstkevakaeknvkknrskavlpydhsrvklkeeasaeksdyinasaildhdprap.ayiatqgplastva

DFWRMVWQQKTQCIVMVTNLEEQGRMKCLKYWPDLapGVSADdlradELPKLQLGPYVVFFKErhehklWTQRVFELEH-EGEGRMTVTQFHMTAWPDHG
|||.|||.| .  ||..|.|||.|  .| .||||   | .       .. ...|    .. ..      .  | | |   . .   ||||||  .||..|
dfwqmvweqGvvvivnltrleeegvkqckrywpde..Gsevy.....hiyevhlvsehiwcdd......ylvrsfylknlqtsetrtvtqfhflswpeeg

VPSEPSDLLYFRQAIRAAFPNPTSPMLVHCSAGVGRSGTFIAIDHMLQLILDEARAAsdvpDVRDVVHGMRDRRNFMVQTEEQYIFIYFAL
||...  || ||. .  ..   ..|..||||.|.||.|..|.|| .|. .|  ..      |.   .  .||.|. .|.|..|. |.. |.
vPasaksllefrrkvnksyrGrscpivvhcsdGaGrtGvyilidlvlnrllkGvkei....diaatlehlrdqrpglvktkdqfefaltav

0041856 (Phosphotyrosine protein) phosphatases II 1239-1486 1.2e-48 160.4 In-house 1-167 (182) alignment
Range on Protein: 1239-1486
Range on HMM: 1-167/182.0
NRDKNRYRNITAYDHSRvvlqvnpeegGCDYYNANYIAGARSPSDYIACQGPTNSSVDDFWRMVWQQKTQCIVMVTnleeqgrmkCLKYWPDLApgvsad
|.|||||..|  |||||          ..|| |||...|.. ....||.|||..|.| ||.||..... ..||..|         .  |||.|       
nldknrysdilpydhsr..........dldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt.........eelywpell......

dlradelpklqlgpyvvffkerhehklwtqrvfelehegegRMTVTQFHMTAWPDHGVPSePSDLLYFRQAIRAafpnPTSPMLVHCSAGVGRSGTFIAI
                                           ...|.. . |||||||. ...|| | .....    .  | ||||||||||.||..|.
.........................................erlgiqylylpwpDhgvpd.ldelldfieevle....eggpvlVHCsaGvgRtgtlvaa

DHMLQLildearaasDvPDVRDVVHGMRDRRNFMVQTEEQYIFIYFAL
. |..|         .  .....|. .| ||. ||.|..||.|.. ||
ylmkkl.........g.vsleeavklvrsrRpgmvitpnqyfflqlal

0051429 (Phosphotyrosine protein) phosphatases II 1268-1511 2.3e-48 160.5 In-house 5-246 (272) alignment
Range on Protein: 1268-1511
Range on HMM: 5-246/272.0
DYYNANYIAGARS---PSDYIACQGPTNSSVDDFWRMvWQQKTQCIVMVTNLEEQGRMKCLKYWpdlaP--GVSADDLRADELPKLQLGPYVVFFKERHE
.|.||... |  .   |  .....||.. ...||||. ....  .||.....||.|| || .||    |   .   ..  |. |   .| ..|.. . . 
gyiNardvggygrvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdryw....pgirylhlpilddsaptilygalrvtllseel

HKLWTQRVFELEHE---GEGrMTVTQFHMTAWPDHGVPSEPsdLLYFRQAIRAafpnpTSPMLVHCSAGVGRSGTFIAIDHMLQLIldearAASDVPD--
.  .. |...|...   ||. ..|...|.|.|||||||.|.  || . .....       |.|||||||..|.||..|....|. .      .... |  
lldyilrellltlllsagea.revmhlhytdwpdhgvpqea..llellellld.....ggpvlvHCsaGkdRTGtvvallllllgv.....sletivddY

------VRDVVHGMRDRRNFMVQTEEQYIFIYFALEMALTAMQATDKADLKMALDEFHQH
      ....|. .|..|  .|||||||.|.| ||  .| ...... . |..|||.....
lltnlyleeaveelraqrpgavqteeqylflyeallellrsllsvraeyllaaldaidee

subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 1237-1486 3.6e-48 158.8 In-house 5-236 (239) alignment
Range on Protein: 1237-1486
Range on HMM: 5-236/239.0
QANRDKNRYRNITAYDHSRVVLQVNPEEGGCDYYNANYIAG-ARSPSDYIACQGPTNSSVDDFWRMVWQQKTQCIVMVTNLEEQGRMKCLKYWPDLAPGV
. |. |||| || .||||||||.   ..   || ||.|.     ||  ||| ||  . |  |||||.||..   |||.| | |  . || .|||| .   
rvnkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdstsky

SadDLRADeLPKLQlgpyvVFFKerhehklWTQRVFELEHEG--EGRmTVTQFHMTAWPDHGVPSEPSDLLYFRQAIRAAFPNPTSPMLVHCSAGVGRSG
   .||   | | .     ||         .  | | . . |  | |  | |.|.| |||.|||   . .| .|. |       . | ..||||||||.|
c..nlrvt.lrkte.....vfad.......yiirtfvmsqvgqteer.yvyqyhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcsagvgrtg

TFIAIDHMLQlildEARAASDVpDVRDVVHGMRDRRNFMVQTEEQYIFIYFAL
.|. || ||.    .|.    | |. . |. .|. | .|||| |||.||..|.
aflvidamlr....qakkqktv.difnyvkairedrphmvqtseqyvfihlav

subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 1237-1486 4e-48 158.6 In-house 6-237 (239) alignment
Range on Protein: 1237-1486
Range on HMM: 6-237/239.0
QANRDKNRYRNITAYDHSRVVLQVNPEEGGCDYYNANYIAG-ARSPSDYIACQGPTNSSVDDFWRMVWQQKTQCIVMVTNLEEQGRMKCLKYWPDLAPGV
. |. |||| || .||||||||.   ..   || ||.|.     ||  ||| ||  . |  |||||.||..   |||.| | |  . || .|||| .   
rvnkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdstsky

SadDLRADeLPKLQlgpyvVFFKerhehklWTQRVFELEHEG--EGRmTVTQFHMTAWPDHGVPSEPSDLLYFRQAIRAAFPNPTSPMLVHCSAGVGRSG
   .||   | | .     ||         .  | | . . |  | |  | |.|.| |||.|||   . .| .|. |       . | ..||||||||.|
c..nlrvt.lrkte.....vfad.......yiirtfvmsqvgqteer.yvyqyhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcsagvgrtg

TFIAIDHMLQlildEARAASDVpDVRDVVHGMRDRRNFMVQTEEQYIFIYFAL
.|. || ||.    .|.    | |. . |. .|. | .|||| |||.||..|.
aflvidamlr....qakkqktv.difnyvkairedrphmvqtseqyvfihlav

subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 1225-1487 2e-45 149.8 In-house 24-274 (287) alignment
Range on Protein: 1225-1487
Range on HMM: 24-274/287.0
QSVGLRHKSCATQANRDKNRYRNITAYDHSRVVLQVNPEEgGCDYYNANYIAGARSPSDYIACQGPTNSSVDDFWRMVWQQKTQCIVMVTNLEEQGRMKC
.|. .  |.    |.  |||| ..  .|..||.|  ..|  | || ||||.|. .    .||.|||  ..| ||||.|.....  ....|   |..|.||
esstatfkaaeelaavkknryadvlPiddtrvllsaegel.GsdyinanyvasytddeafiaaqgPiaatvrdfwravletrsasvitmtreveearlkc

LKYWPDlapgvsaddlRadELPkLQLGPY-VVFFKERHEHKLWTQRVFELEH-EGEGRMTVTQFHMTAWPDHGVPSEPSDLLYFRQA----IRAA-FPNP
 ||||.          |  | | ...| | || ..    .  .. | . | . |..    | |... .|||....     |. |       | .|   . 
ykywPe..........r..evP.mrvGGysvvlldydikePeygvralrlidletrearvvkqldllswPdkvlaPtavglirfvldvkqhielardase

TSPMLVHCSAGVGRSGTFIAIDHMLQLILDEARAasdvpDVRDVVHGMRDRRNFMVQTEEQYIFIYFALE
. |..||...|.||||...|.  ...  .|  |      ||  ||  .| .|. .||.  |. ..| || 
vGPlvvhddvGiGrsGillatlvlvsrledlGrv.....dvaavvirlreyraalvqavvqlrllyealv

subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 1219-1485 2.2e-45 150.0 In-house 20-272 (307) alignment
Range on Protein: 1219-1485
Range on HMM: 20-272/307.0
TEFSRLQSVGLR-HKSCATQANRDKNRYRNITAYDHSRVVLQVNpeEGGCDYYNANYIAGARSPSDYIACQGPTNSSVDDFWRMVWQQKTQCIVMVTNLE
 ||. |           | .|| |||||... . |..|.|....      ||  |||.  |  |  .|..||| .... .|| |. |.| ....|. .. 
defrvlakktpegvtveafsantdknryqdvkcqdkgrivvkfd..glasdyihanylgiaikpkkficaqgplentqysfwamaiqekvesvimlckvi

EQGRMKCLKYWPDLAPGVSADDLRADELPKLQLGPYVVffkeRHEHKLWTQRVFELEHEGEGRmTVTQFHMTAWPDHGVPSEPSDLLYFRQAIRAAfpnp
| ...|| .|||       .   ... .   .||   .      ...|     ....  .. | |....  . |||.|||      . . .|.|      
elakikceqywpleegqklvfgeapntisvanlgakkl....apdedlinvttlkvdwaqksr.tiqhlqwenwpdrgvpqinltainlleavryd....

TSPMLVHCSAGVGRSGTFIAIdhmlQLILDEARAASDVPDVRDVVHGMRDRRNFMVQTEEQYIFIYFA
| |..|||||||||||| .||     |. |   |  .  |....|. .|..|.. .||| ||....  
tnpvvvhcsaGvGrsGtivai....slvqdkmiaGinckdmkklveelrsqrhyaiqteaqylylhrv

subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 1222-1494 8.4e-44 144.5 In-house 16-271 (283) alignment
Range on Protein: 1222-1494
Range on HMM: 16-271/283.0
SRLQSVGLRHKSCATQANRDKNRYRNITAYDHSRVVLQVNPEeggcDYYNANYIA---GARSPSDYIACQGPTNSSVDDFWRMVWQQKTQCIVMVTNLEE
 ||    |  .  ... |. |||...| ..|  || |. ...    || || .|      .   .||..|.| .  | |||.||...|  .|||.|.| |
krlsvpdldadiasadenkrknrnqeivpadqwrvelksesr....dyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfdekitaivmltklqe

QGRMKCLKYWPDlaPGvsaddlradelpKLQLGPYVVFFKERHEHKLWTQRVFELEHE--GEGRMTVTQFHMTAWPDHGVPSEPSDLLYFRQAIRAAFPN
. |.|| .|||    |              . |.. |  ..   .. .... . | ..   .  . .. . .  | . |  .    |. | . |     .
dlrikCsqyWPk..rG............sedyGeftvtlrkettsnsfiikelllrvnssakstlllahyqvidWleygeqaiinslvkfnkvislqtes

PTSPMLVHCSAGVGRSGTFIAIDHMlqliLDEARAASdVPDVRDVVHGMRDRRNFMVQTEEQYIFIYFAL-EMALTAMQ
. .|..||||.|.||...|||.       ...|.. | | ||  ||. || .|  .||| .|| ... .  | ||    
kkgPivvhCstgiGrtavfiaasas....vkdaltes.vvdvfavvkimreqrmmavqtldqyklvhelvleqalcgdt

0036282 (Phosphotyrosine protein) phosphatases II 1267-1483 1.7e-43 143.7 In-house 2-163 (174) alignment
Range on Protein: 1267-1483
Range on HMM: 2-163/174.0
CDYYNANYIAGARSPSDYIACQGPTNssvddFWRMVWQQKTQCIVMVTNLEEQGRMKCLKYWPDlapgvsaddlradelpklqlgpyvvffkerhehklw
 ||.||... . . .. .||.|||..     ||.|..... ...||.....| |. ||  |||.                                    
sdyinaspldlsyitprliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe....................................

tqrvfeleHEGEGRMTVTQFHMTAWPDHGVPSEPSdLLYFRQAIRAAFPN-PTSPMLVHCSAGVGRSGTFIAIDHMLQLILdearaaSDVPDVRDVVHGM
        .    . .. |.. . |||||||. .  || | .... |. . |  |.||||||||||.||..|.. ||...|      ... |. |.|. .
........lredlerlgiqylylpwpDhgvpdlsi.llefvkfveealsedpggpvlVHCsaGvgRtGtlvaaylmlrgll......eslvdaldlvrel

RDRRNFMVQTEEQYIFIY
|  |  ||||..||.|.|
RlqrpgmvqtpsQyrfly

subfamily_CG7180_pd Subfamily CG7180 1234-1488 1.2e-42 140.6 In-house 34-288 (296) alignment
Range on Protein: 1234-1488
Range on HMM: 34-288/296.0
CA---TQANRDKNRYRNITAYDHSRVVLQVNPEEGGCDYYNANYIAGARSPSDYIACQGPTNSSVDDFWRMVWQQKTQCIVMVTNLEEQGRmKCLKYWPD
||    . ||.|||. ..  ||. ||||.    |   || || |. .   . .||  ..|....||.|||.|........|..|.  .. . ....||| 
CagglrkenreknrdvkvvPyDynRvvLekldGeeksdYinavyvdsflkkkeyivteapkketvdefWrlvydeeisavvvLtktfdfak.mypsywpn

LApGVSADDLRADELPKLQLGPyVVFFKERHEHKLWTQRVFELEHEGEGRmTVTQFHMTAWPD-HGVPSEPSDLLYFRQAIRAAFPNP-----TSPMLVH
 .      ..  . . . |.   ..  . .  .|. .    | . . | | .|..|..| |.  . ||.  . |...|. .|    .      ..|..|.
ks.keqygeifveiveekqyan.lkirtfkltkkivalteqekqvkaetR.ivklfqlteWeledkvPlstnalielrrrvrlwrekvdedpeegPvvvv

CSAGVGRSGTFIAIDHMLQLILDEARAasdvpDVRDVVHGMRDRRNFMVQTEEQYIFIYFALEM
.| |..||| ..|||  |.|.  | .      || . |  .|  |. .|.. |.| .||  |. 
ssdGasRsGvylaidanlelvekeeev.....dvFeavktlrrsRpqLvenveeYkyiYdvlle

0043147 (Phosphotyrosine protein) phosphatases II 1265-1483 1.5e-42 140.5 In-house 3-154 (172) alignment
Range on Protein: 1265-1483
Range on HMM: 3-154/172.0
GGCDYYNANYIAGARSPSDYIACQGPTNSSVDDFWRMVWQQKTQCIVMVTNLeeqgrmkclkywpdlapgvsaddlradelpklqlgpyvvffkerhehk
.|.||.||.|. . . | ..||.|||... ..|||||..... ..||..|.|                                                
egsdyinasyldlyyipdrfiatqgplrntladfwrmlkelgithivnltel................................................

lwtqrvfeLEHEGEGRMTVTQFHMTAWPDHGVPsEPSDLLYFRQAIRA-AFPNPTSPMLVHCSAGVGRSGTFIAIDHMLqlilD-EaraasdvpDVRDVV
        |        .. |.. . |||||||  .. || | . |.  .  .|  |.||||||||||.||..|.. ||               .. ..|
........lydpellerlgiqylylpwpDhgvp.llellleflefidellalspggpvlVHCsaGvgRtgtlvaaylml....lgl........sleeav

HGMRDRRNFMVQTEEQYIFIY
. .|..|. .||...||.|.|
alvrekRpgavqnpsqyrfly

0049772 (Phosphotyrosine protein) phosphatases II 1234-1489 1.7e-41 138.3 In-house 41-279 (314) alignment
Range on Protein: 1234-1489
Range on HMM: 41-279/314.0
CATQANRDKNRYRNITAYDhSRVVLQVNPEEGgCDYYNANYIAGArspSDYIACQGPTNSSVDDF----------WRMV--WQQKTQCIVM---------
.   .||||||| .|  .| .||.|.  | .| .||.||.|. |     ..||.|||..  |.||          ||||  .....  |||         
adlflnrdknryldilpad.nrvilpglpvsg.sdyinasyvdgf...lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivmsrdevlade

------------VTNLEEQGRMKCLKYWPDLApgvsaddlradelpklqlgpyvvffkerheH-----KLWtqrvfelehegegRMTVTQFHMTAWPDHG
             ..| ..| . . .....|                                     .|.               .. ... . .||..
lsrLdaAlgKtpllildgngneptaadlellk..............................eelydpelf.............erlgikylripvpDgs

VPsEPSDLLYFRQAIRAAfpNPTSPMLVHCSAGVGRSGTFIAIDHMLQLIldearaasDVpDVRDVVHGMRDRRN-----FMVQTEEQYIFIYFALEMA
.|  ..|.. | ..|..|  .. .| ||||.||.||.|||.... .. |         .| ....... .| .|       .... |||.||. ||...
ap.lledfdeflefieea..dkggpvlvHCkaGkgRtgtfvvaaylmkll........gv.sleealedvrlkRpinpnpgfieqleqyefilealley

0046846 (Phosphotyrosine protein) phosphatases II 1258-1486 1.7e-41 137.2 In-house 3-169 (176) alignment
Range on Protein: 1258-1486
Range on HMM: 3-169/176.0
LQVNPEEGGCDYYNANYIAGARspsdYIACQGPTNSSVDDFWRMVWQQKTQCIVMVTNLEEQGRMKCLKYWPDLAP-GVsaddlradelpklqlgpyvvf
|..  .....|| |||.|.|.|    .||.|||..... ||..|..... ...|..|.. | || ||  |||.|   |.                     
lrllgldldldyinanlilgsr....piatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgi.....................

fkerhehklwtqrvfelehegegrmtvtQFHMTAWPDHGVPSEpSDLLYFRQAIRAAFPNPtSPMLVHCSAGVGRSGTFIAIDHMLQlildearaaSDVP
                            |.. . |||||||.  ..|| . ..|| |  .   | |||||||.||.||..|.. .           .   
............................qylhlpwpDhgvpdl.elllellefirealkeg.gpvlVHCsaGigRtgtlvaayllel.........ekgl

DVRDVVHGMRDRRN-FMVQTEEQYIFIYFAL
.| .... .|..|  ..|||.||| |.| ..
sveealalvreqRplgavqtpeQyrflyefe

subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 1202-1486 2.9e-41 136.2 In-house 8-283 (305) alignment
Range on Protein: 1202-1486
Range on HMM: 8-283/305.0
AILQHLQSKLDA-EGGLQTEFSRLQSVGLRHK--SCATQANRDKNRYRNITAYDHSRVVLQVNpeeGGCDYYNANYIAGARSPSDYIACQGPTNSSVDDF
 ||. ... |.    ||..||. .. .   .|  .     ...||||...   |. || |.        .|  |||..    |  .| .| | . .  ||
qilkfvkrtlekgpaglraefvamkrfndfekmkafkeaqeagknrykdvgcldnnrvklegp...wpheyihanyvstptnpkrfictqaplektcadf

WRMVWQQKTQCIVMVTNLEEQGRMKCLKYWPDLAPGVSADDLRADELP-KLQlGPYVVFFKERHEHKLwTQRVFELEHEGEGRMTVTQFHMTAWPDHGVP
| | .|.| . | |. || |.|  |||.|..     |   . . . .  |..     . |..  . |. |. |. .|  ||    ||..|   ||| |||
wymclqdkveaifmlcnllekgakkcleyfaskdkdvlefeekgqkisvkfe.ssvtlkfrkdakakv.tetvlviegpgekarkvthyhwidwpdrgvp

SEPSDLLYFRQAIRAAfpnpTSPMLVHCSAGVGRSGTFIaidhMLQLILDEARAASDVPDVRDVVHGMRDRRNFMVQTEEQYIFIYFAL
.    .| . .  |..      |. ||||||.||.|. .    ||. |||.  |   . |   ..  .|..||  .||..||.|..  .
aadlailellekarps....kgpivvhcsagigrtgsvv....mleyildqllagqiiedtdkilqkireqrnnsiqtdaqylfvhqvi

subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 1236-1484 4.7e-41 135.4 In-house 52-283 (305) alignment
Range on Protein: 1236-1484
Range on HMM: 52-283/305.0
TQANRDKNRYRNITAYDHSRVVLQvNPEegGCDYYNANYIAGARSPSD-YIACQGPTNSSVDDFWRMVWQQKTQCIVMVTNLEEQGRMKCLKYWPdLAPG
.. .  ||||... . |.| | |. .|    .||  |||.     |   .|..||| . ..|.|| || |.| . |||. .  | |..|| .||| .| |
adiaitknryqdvpcqdqsavkld.kps..psdyihanyvgcpmipekrficaqgpldqtidefwwmviqnkveqivmlcktvelgklkcaqywp.aaqg

VSaDDLRADELPKLQLGpyvvfFKERHEHKLWTQRVFELEHEGEGRMTVTQFHMTAWPDHGVPSEPSDLLYFRQAIRAAfpnpTSPMLVHCSAGVGRSGT
    .|..  . .   |      |  .        ...| . |. .|.| ... | ||| |||      | .  ||| .      |..||||||.||.||
ek.lelksgivvenvsg.....skpmerdaeiqitllnltysgdqkmsvrhlqwtewpdrgvppckltslellsairgs....kvpivvhcsagigrtgt

FIAIDHMLQLILDEaraaSDVPDVRDVVHGMRDRRNFMVQTEEQYIFIYF
 .||...|. | ..     ..| . ..|. .||.| | .|.. ||.||. 
ivaieyilekiaen....kpcppmpelvkalrdqrafsiqndvqylfihr

subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 1237-1488 2.3e-40 133.0 In-house 35-268 (281) alignment
Range on Protein: 1237-1488
Range on HMM: 35-268/281.0
QANRDKNRYRNITAYDHSRVVLQV-NPEEGGCDYYNANYIAGARSPSDYIACQGPTNSSVDDFWRMVWQQKTQCIVMVTNLEEQGRMKCLKYWPDLAPGV
  |  |||| || . | ||| |.|  |..   ||  ||||        ||  ||| . .  |||||.||..| .|||. .. |  | || .|.|  |  .
pvnnkknrylnipcldisrvqlkvkmpnknstdyihanyirspflkrgyiltqgpkketradfwrmiwqenttaivmlcqfletnrekcaeyfprnahcc

saddlradelpkLQLGPYVVFFKERHE-HKLWTQRvFELEHEGEGRMtVTQFHMTAWPDHGVPSEPSDLLYFRQAIRAAfpnpTSPMLVHCSAGVGRSGT
            ||.  . | ...    . | | | ..| .||| |. .|..    |||  ||     .|   . |||     ..| ..|||||||||||
............lqfdklsvsyedstvnkslvttr.lnlsyegetrl.ithwlwkewpdwqvpessevmlkilrkirar....stppvihcsagvgrsgt

FIAIDHMLQLIldeaRAASDVPDVRDVVHGMR-DRRNFMVQTEEQYIFIYFAL-EM
..|..  || |    ..   .||....|  .|   |   ||| .||..|.  | ..
lmaveialqsi....hshftlpdikqivshlrvtgraasvqtlqqymliwkvlldf

0049260 (Phosphotyrosine protein) phosphatases II 1275-1483 6.6e-40 131.6 In-house 2-143 (152) alignment
Range on Protein: 1275-1483
Range on HMM: 2-143/152.0
IAGARSPSDYIACQGPTNSSVDDFWRMVWQQKTQCIVMVTNLEEQGRMKCLKYWpdlapgvsaddlradelpklqlgpyvvffkerhehklwtqrvfele
| | . |  .||.|||.. ...|||||..... ..|||.|.|.| |. || .|.                                              
idgyampfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi..............................................

hegegrmtvtQFHMTAWPDHGVPSEPSDLLYFRQAIRAAFPNPTSPMLVHCSAGVGRSGTFIAIDHMLqlildearaasDVPDVRDVVHGMRDRRNFMVQ
          |.. . |||||||. .  || . ..|. .  ..  | ||||||||||.||..|.. ||              .. ..|  .| .|. .|.
..........qylhlpwpDhgvpdlsqlllflllfieklaldkggpvlVHCsaGvgRtgtlvaaylml...........lgvsleeavalvrekRpgavp

TEEQYIFIY
...|..|.|
npgqlrfly

subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 1239-1482 9.5e-38 124.5 In-house 56-275 (290) alignment
Range on Protein: 1239-1482
Range on HMM: 56-275/290.0
NRDKNRYRNITAYDHSRVVLQvnpEEGGCDYYNANYIAGARSPsdYIACQGPTNSSVDDFWRMVWQQKTQCIVMVTNLEEQGRMKCLKYWPDLAPGVsad
.  ||||....  | .||.|.   . .  ||  |||. | ...  .|  ||.....| |.|||| |.|.  |||. .| |.|. || .|.|. .  |   
efkknrykdvvcndktrvilk...dGydGdyvhanyvkGlkam..filtqGalkdtvidiwrmvlqekvaaivmlceliedGkakceqyypekeGev...

dlradelpkLQLGPYVVFFKERHEHKL-WTQRVFELEHEGEGRM-TVTQFHMTAWPDHGVPSEPSDLLYFRQAIRAAfpnpTSPMLVHCSAGVGRSGTFI
         | .| . |   | ...     .... . .  .|.   .  ... .|||. |.     ||   ...| |    . |. ||||||.||.|||.
.........ltfGeitvlcseeddkdaniikktlsvrdkdsGkehklkhlkikswpdksvalstlallrtlrilrka....sGpvvvhcsaGiGrtGtfv

AIDHMLQLILDEArAAsdvpDVRDVVHGMRDRRNFMVQTEEQYIFI
||.  ||..||   .     |. |.|  .|. |   || . ||. .
aievglqilldGk.el....dlldlvralrnsrlnsvqvdiqylal

subfamily_ptpA1_pd Subfamily ptpA1 1200-1443 1.2e-37 124.6 In-house 6-254 (418) alignment
Range on Protein: 1200-1443
Range on HMM: 6-254/418.0
VDAILQHLQSKLDAEGGLQTEFSRL-QSVGLRHKSCA-TQANRDKNRYRNITAYDHSRVVLQVNPEEGGCDYYNANYIAGARsPSDYIACQGPTNSSVDD
. . .  |. .. .   .. ||  | .|||    |    . |  |||| ||   .|.|| |.   .. | || ||||| ||  | ..|. |||   .. |
ikssiynlknhikcihkikeefrlleesvgpsetsegdkkhntsknrytnilpvnhtrvqlkkiqdkegsdyinanyidgay.pkqfictqgplpntiad

FWRMVWQQKTQCIVMVTNLEEQGRMKCLKYWPDLAPGvsaDDLRADELPKLQLGPYVVFFKE---RHEHKLWTqRVFELEHEGEGRmTVTQFHMTAWPDH
||||||... . |||..   |. |.|| .|||.   |   ...      .  .| | | . |     |... | |   |  ||| |  .||..   ||||
fwrmvwenrcriivmlsresencrikcdrywpeqigg...eqfsiygngnevfgtysvelveviqdpereiit.rnirltfegetr.ditqyqyegwpdh

GVPSEPSD--LLYF----RQAIRAAFPNPTSPMLVHCSAGVGRSGTFIAIDHMLQ
 .|        | .    ||       .   |..|||||||||.||| .   |..
nipdhtqpfrqllhsitnrqnqiipssdrnvpiivhcsagvgrtgtfctavimmk

0044763 (Phosphotyrosine protein) phosphatases II 1251-1486 4e-36 119.7 In-house 2-167 (178) alignment
Range on Protein: 1251-1486
Range on HMM: 2-167/178.0
YDHSRVVLQVNPEEGGCDYYNANYIAgarsPSDYIACQGPtnssvDDFWRMVWQQKTQCIVMVTNLEEQGRMKCLKYWPDLAPgvsaddlradelpklql
.|..||.|.  . . ..||.||..|     |  |.....|      |......... ..||..|.  | |..||..|||. |                  
ldrtrvllsnleglersdyinaseil....pglylgslpp.....addlellkelgithivnlteelelgflkcdpywpeeag.................

gpyvvffkerhehklwtqrvfelehegegrmtvTQFHMTAWPDHGVPSEPSDLLYFRQAIRAAFPNPTSPMLVHCSAGVGRSGTFIAIDHMLQLildear
                                  |.. . .||||||. .. .| | ..|..| ... .| |||||||||||||..|.. |..|      
.................................iqylhipipDhgvpdllehflefvefieealdekggpvlVHCsaGvgRsgtlvaaylmkkl......

aasDVpDVRDVVHGMRDRRNfMVQTEEQYIFIYFAL
   .. .. .... .| ||. .|....|. ..|   
...gl.sleeaielvrerRp.ivpnpgqlrqLyefe

0051082 (Phosphotyrosine protein) phosphatases II 1268-1486 1.8e-34 113.8 In-house 4-149 (151) alignment
Range on Protein: 1268-1486
Range on HMM: 4-149/151.0
DYYNANYIAGArspsdYIACQGPTNssvdDFWRMVWQQKTQCIVMVTNLEEQGrmKCLKYWPDLApgvsaddlradelpklqlgpyvvffkerhehklwt
||.|..|. |      .....||..    ||........ ..||.....|| |  .| .|.|.|                                    
dyinfsyvtgg.....lyrsggpla....dflellkelgiktivnlrseeerg..ycpeylpelg...................................

qrvfelehegegrMTVTQFHMTAWPDHGVPSEPSDLLYFRQAIRAafpNPTSPMLVHCSAGVGRSGTFIAIDHMLQLildearaasdvPDVRDVVHGMRD
             ..|...... |||.|.|  .  .| | .....   ..  |.|||||||.||.||..|.. ||.             .. .... .| 
.............ievlhipildwpdpglplsfdavleflellld...kkngpvlvHCsaGkgRTGtlvalylmllg...........vsleealeeyrl

RRNFMVQTEEQYIFIYFAL
.|  .||...|..|..|||
krpgvvqpnqqflfqlfal

subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 1239-1408 5.2e-34 112.5 In-house 33-191 (297) alignment
Range on Protein: 1239-1408
Range on HMM: 33-191/297.0
NRDKNRYRNITAYDHSRVVLQVNPEEggCDYYNANYIAGARSPS--DYIACQGPTNSSVDDFWRMVWQQKTQCIVMVTNLEEQGRMKCLKYWPDlapgVS
   |||||.| |.| .|| |.  . |   || ||.|..    ..   ||  |||....|||||..|..|  . ||||..|.|.|| ||  |||.    | 
slrknryrdilatddtrvkllrvite..rdyinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmvaklqedGrdkcapywps....vv

ADDLRADELpklqLGPYVVFFKERHEHKLWTQrvFELEHEgEGRMTVTQFHMTAWPDHGVPSEPSDLLYFRQ
 . |.| ..    .  ..  . . ...   |.  ..| .  . .  |.     .||||||||.  ||  |. 
qerlkagdv....vveflsstsdefdrvilte..lqliyr.sesrvvrhvqflswpdhGvpsdledlvrfqa

PTPc_DSPc_SM00012 1382-1485 2.3e-32 106.7 In-house 1-102 (105) alignment
Range on Protein: 1382-1485
Range on HMM: 1-102/105.0
TVTQFHMTAWPDHGVPSEPSDLLYFRQAIRAAFPNP--TSPMLVHCSAGVGRSGTFIAIDHMLQLILDEAraasDVPDVRDVVHGMRDRRNFMVQTEEQY
||...|.|.|||||||.|....| . .|..    .   ..|..|||||||||.|||.|.| .|| . .|     . .|. ..|. .|..|. ||||||||
tvkhyhytgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleket....kevdifqivkelrkqRpgmvqteeqy

IFIYFA
.|.| |
lflyra

subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 1238-1490 3.2e-31 103.4 In-house 42-271 (288) alignment
Range on Protein: 1238-1490
Range on HMM: 42-271/288.0
ANRDKNRYRNITAYDHSRVVLQvnpeeGGCDYYNA-NYIAGARSPSDYIACQGPTNSSVDDFWRMVWQQKTQCIVMVTNLEEQGRMKCLKYWPDlAPGVS
||  ..||.|.   | .|| |.       .|.| | | .. |. .   | .| | |. .. .|.|. ..  . |||...| |.|. |  .|.|    | .
anptrdryenlprcditrvkls.....ddpdfyiaanvvssakykrrlicaqaPlngtieelWkmllesdveyivmlcellekGkeksaeyfPs.klGek

ADDLRAdelpklqlgPYVVFFKERHEHKLWTQRVFELEHEGEGRMTVTQFHMTAWPDHGVPSEPSDllYFRqaIRAAFPNPTSPMLVHCSAGVGRSGTFI
|   |            ||  |    .|| .  ..  ..||| .. | . |.  |.|.||| .     ..|  .   . . . |..||.||||||.||.|
arigrl.........ctvvkkkradidklvkvsllriskegeekvivkilhlleWdddgvPenyls..plr..llevlkslqkPivvhssaGvGrtgtli

aidhmLQLILDEARAASDVPDVRDVVHGMRDRRNFMVQTEEQYIFIYFALEMAL
     | ||  |.   .|   .| ... .|. |   .||| ||....  .   |
.....lilialeslrlddflgirsllaklreerfkaiqtemqylyvhrcvleel

subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 1212-1486 2.5e-28 93.8 In-house 3-255 (267) alignment
Range on Protein: 1212-1486
Range on HMM: 3-255/267.0
DAEGGLQTEFSRLQSVGLRHKSCAT---QANRDKNRYRNITAYDHSRVVLQVNPEEggcdYYNANYIAGARSPSDYIACQGPTNSSVDDFWRMVWQQKTQ
| |  .. ||  .. .   .  ...   . |...||. .   ||..||.|. . ||    | || |. | .    .|. |.| . .. ||. .. .||  
deeceiekefelikkisdtsstisqsiaeknqernrlddnlpyddtrvilrtkeee....yinasyvegyktknafivtqdplkntitdfltvihdqkvp

CIVMVTNLEEQgrmKCLKYWP-DLAPGVSADDLRADElpklqlgpyvVFFKERHEHKLWTqrvFELEHEGEGRMTVTQFHMTAWPDhGVPSEPSDLLYFR
 ||..|.  ..   .  ..||  ..     .||  .            . ||  .... |   .||. . |    || ..   |    .  .|     | 
vivlltkvftd...nirlfwPPkmgqakkyqdltveh..........slekeendyqiit...lelkfknesahnvtlyyykkwni.ntnnkpylkplfg

QAIRAAFPNPTSPMLVHCSAGVGRSGTFIAIDHMLQLILDEaraasDVPDVRDVVHGMRDRRNFMVQTEEQYIFIYFAL
   .  . |   |..|.||.||||||||. || .|. .  |     .| |. | .  .|..|  .|.| |.||.|.  |
ilaknqlengnrPlvvacsdGvGrsGtflvidsqlerakte.....gvsdifdflrkirsqriglvdtkeryiyihell

subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 1234-1486 1.3e-26 88.3 In-house 30-266 (285) alignment
Range on Protein: 1234-1486
Range on HMM: 30-266/285.0
CATQANRDKNRYRNITAYDHSRVVLQVNpeegGCDYYNANYIA-GARSPSDYIACQGPTNSSVDDFWRMVWQQKTQCIVMVTNLEEQGRMKCLKYWPDLA
 | .|| | ||| .. . . .||||.        ||  |...    .  | ||. |||   .. |||.|..|.|   ..|.  | | |  ||  |.|.  
tayeanpdlnryadvrcieetrvvlknh....drdyihaswmrmpgkdqstyittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekcalyypekl

PGVsaddlradelpkLQLGPYVVFFKERHEHK----LW-TQRVFELEHEGEGRMTVTQFHMTAWPDHGVPSEPSDLLYFRQAIRAAFPNpTSPMLVHCSA
  |            ...| | . . | .|      .. .  | . |      . . . ..  |||.  | .   .. . . ..   |.   |. |||||
gev............vkfgkyeitlteckeeaiagtilnaltvintedasseplymnhvqvpwwpdqlapedarpmielykwvkkvnpk.ekpicvhcsa

GVGRSGTFIAIDHMLQLILDEARAasdvpDVRDVVHGMRDRRNFMVQTEEQYIFIYFAL
||||. ||. ||.    |...        .. |.|. ||  |   ||.  |..|.|  |
gvgrtatfvgidyatirimenpni.....emldivremramrfqavqshmqflflyvvl

subfamily_CG42327_pd Subfamily CG42327 1238-1405 1.6e-25 84.4 In-house 27-185 (319) alignment
Range on Protein: 1238-1405
Range on HMM: 27-185/319.0
ANRDKNRYRNITAYDHSRVVLQVNPEEGGCDYYNANYIAGAR-SPSDYIACQGPTNSSVDDFWRMVWQQKTQCIVMVTNLEEQGRMKCLKYWPDLAPGVS
. .||.|. |.    ..|||||  ...    | .|.|. | . .|. |||.| . ..|  ||||.||.|... || .|.| |.|  .| .|.|  . . .
tskdksrvinvvPlPetrvvlqrigdddkdeyldasyvrGyddapnsyiaaqvsledsssdfwrtvweqqsrvivqltdlselGikvcaeylPtketldn

AdDlradelpklQLGPYVVFFKERHEHKLWTQRVFE-LEHEGEGRMTVTQFHMtAWPDHGVPSEPSDLLY
  .           | . | .|.|  .. .    .   . ..|    .| .    |.. .||.|.. |. 
t.s.........lyGdilvtlkgrevkdryaistlllkrvdkeesrelthywy.kwleaevPaeeaalia

subfamily_egg_pd Subfamily egg 1233-1487 2e-25 84.1 In-house 34-267 (307) alignment
Range on Protein: 1233-1487
Range on HMM: 34-267/307.0
SCATQANRDKNRYRNITAYDHSRVVLQVNPEEGGCDYYNANYIAGARSPSDYIACQGPTNSSVDDFWRMVWQQKTQCIVMVTNLEEQgrMKCLKYWPDla
 .|.. |..| | . .   | ||| |...      |.  ||.. |     ..| .| |   .||||||||.|.. | |||.|   |    .|  |||   
taasdnnlekarskrvhckdssrvklelrrGqylddfihanrvkGkpllnefilaqaplkntvddfwrmvfqeevqyivmltsrkes..erceyywpk..

pgVSADDLRADeLPKLQLGPYVVFFKERHEHKLWTQRVFELEhegegrmtVTQFHMTAWPDHgvPSEPSDLLYFRQAIRaAFPNPTSPMLVHCSAGVGRS
    .| |.      |..  . |  |     ..   ..   .          . ..  |       . ||. .  . .|    | . |..|..  || ..
..aesdslvtv.pGslrienlkvdskadplfrvtklklvGgd........deerflehwqgd..vnnssdvysplrvlr.klrnlskpvvvqdilGvska

GTFIAIDHMLQLILDEaraASDVPDVRDVVHGMRDRRNFMVQTEEQYIFIYFALE
.|..||.  |  .|           |.  |  .| ||.. |..  .|.|.|  . 
atlvaieiallsllrG...pitkslvlravvflrlrrrlsvesvllylfvyrlvl

0048076 (Phosphotyrosine protein) phosphatases II 1345-1486 2.7e-25 84.1 In-house 8-139 (145) alignment
Range on Protein: 1345-1486
Range on HMM: 8-139/145.0
LPKLQLGPYVVFFKERHEHKLWTQRVFELEHEGEGR-MTVTQFHMTAWPDHGVPSEPSDLLYFRQAIRAAFPNPtSPMLVHCSAGVGRSGTFIAIDHMLQ
||.| ||.. .  . .. ..|   .|. | .| |.   ...|.. . |||||||. ...|| | ..|..| ...  |.||||||||||.||..|.. ||.
lpglylgslptaldlellkdlgittvlnltselellerlgiqylylpwpDhgvpdllellleflefieealkeg.gpvlVHCsaGvgRtgtlvaaylmll

lildearaaSDvPDVRDVVHGMRDRRNFMVQTEEQYIFIYFAL
          .  .. .... .| .| ..|....|..|.| ..
.........lg.vsleealelvrsqrpgavpnpgqlrflyefe

subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 1237-1485 8.9e-25 82.0 In-house 41-271 (312) alignment
Range on Protein: 1237-1485
Range on HMM: 41-271/312.0
QANRDKNRYRNITAYDHSRVVLQVNpeEggCDYYNANYIAGARSPSDYIACQGPTNSSVDDFWRMVWQQKTQCIVMVTNLEEQGRMKCLKYWPDLAPGVS
   .| ||| ||  .|  |  |  .  |    |  ||..     |  ....||| ....  ||...    . .|.... . |.|  || ||  |.   | 
lkfkdlnrypniqcwdrgrftlagd..e..nfyihanfvkictkperfvctqgplentcthfwqlalslgstsiillcgfvedgsekcakyisdivgfvd

ADDLRA--DELPKLQLGPYVvffKERHehklwTQRVFELEHEGEGRM-TVTQFHMTAWPDHGVPSEPSDLLYFRqairAAFPNPTSPMLVHCSAGVGRSG
 .| |   .   ....|      |..      |.||. .     |.   . ..  ..|||||.|      | .     .|  .   |.. ||||||||.|
ledhrvyteycteieiggks...kdki.....thrvlkvvvkatgqesklnhyqwaswpdhgmpdscdtalrll....savkkdkkpviahcsagvgrtg

TFIAIDHMLQLiLDEARAAsdvpDVRDVVHGMRDRRNFMVQTEEQYIFIYFA
|.. |. |.   |   |      .|.|.   .|  |   |..  ||..   .
tlaliesmiaa.lrhprkq....nvkdsfvllrkdrarsvrvfpqyvyalrc

subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 1238-1482 4.7e-24 79.7 In-house 49-273 (301) alignment
Range on Protein: 1238-1482
Range on HMM: 49-273/301.0
ANRDKNRYRNITAYDHSRVVLQVNpeeGGCDYYNANYIAGARSPSDYIACQGPTNSSVDDFWRMVWQQKTQCIVMVTNLEEQGRMKCLKYWPDLAPgvsa
 ..||.|| ..    .. | . |.   |      ||.|     |  .|| ||| ... .||| |. | . . |||...  |.   || .| |   .    
lpkdkhryptvPckPstavevivd...GkrvPihanwiptsGhphrfiatqgPlkntsedfwamlvqydvekivmlgqkvekleekceeylpvkis....

ddlradelPKLQLGPYVVFFKERHE--HKLWTQRVFELEHEGE--GRMTVTQFHMTAWPDHGVPSEPSDLLYFRQAIRAAfpnpTSPMLVHCSAGVGRSG
         ||..| . .  |...   .|  ..| .|.|   .     ||| .  . |.|.|||    .|  . . .. .      |..||||||.||| 
........ekldigrfkikiknkelilnkkiskrtlevedstgkfatrtvthyqysewtdrgvPkshaelfdlmelvkks....ekPivvhcsaGiGrsv

TFIAIDHMLQLILDEARAasdvpDVRDVVHGMRDRRNFMVQTEEQYIFI
.||. . . . .. . .      .. . .. .|..|   |||..|  ..
afigteylareveadpti.....eltealkhlrehrwngvqtnsqlywm

0048179 (Phosphotyrosine protein) phosphatases II 1372-1484 4.8e-24 80.1 In-house 39-139 (144) alignment
Range on Protein: 1372-1484
Range on HMM: 39-139/144.0
ELEHEGEGRMtVTQFHMTAWPDHGVPSEPSDLLYFRQAIRAAFPNPtSPMLVHCSAGVGRSGTFIAIDHMLqlildearaASDvPDVRDVVHGMRDRRNF
| |.| ..|. ..|.. . |||||||. ...|| | ..|..| ...  |.||||||||||.||..|.. |.           .  .. .... .| || .
eyepeflere.giqylhlpwpDhgvpdllellleflefieealeeg.gpvlVHCsaGvgRtgtlvaaylmk.........klg.lsleealalvrsrrpg

MVQTEEQYIFIYF
.|....|..|.. 
avpnpgqlrfLle

subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 1241-1331 7.9e-23 75.7 In-house 49-153 (350) alignment
Range on Protein: 1241-1331
Range on HMM: 49-153/350.0
DKNRYRNITAYDHSRVVLQ--------VNPEEGGCDYYNANYIAGA----RSPSD--YIACQGPTNSSVDDFWRMVWQQKTQCIVMVTNLEEQGRMKCLK
 ||||.||  |.|||| |.        ..    . || ||||.  .    .  .|  ||| |.|. | ||||.... . | . |...|.. |... || .
aknrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvkvilsltsdvelnlekcyr

YWPDL
||...
YWqeg

subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 1289-1490 5.6e-22 72.5 In-house 98-288 (302) alignment
Range on Protein: 1289-1490
Range on HMM: 98-288/302.0
GPTNSSVDDFWRMVWQQKTQCIVMVTNLEEQGRMKCLKYWPDLAPGVSadDLRADELPKLQLGPYVVFFKERHEHKLWTQRVFELEHEGEGRMTVTQFHM
 | .|... .| .. | ..  .| .... |..  || .|. |   |.    ..   .  ...   .  | .... ||.|  . . ... . ..||  .. 
vpkkstlekhwalieqynvaivvqlcsfvedeekkcaeyysdkvggel..kfgrytvktvsvktdleeftdkksfklytveiknekkkkkvkktvdilaf

TAWPDHGVPSEPSDLLYFRQAIRAaFpnpTSPMLVHCSAGVGRSGTFIAIDHMLQLILDEaraasDVPDVRDVVHGMRDRRNFMVQTEEQYIFIYFALEM
.|||||| | |.   |   .   . .      .||||||||||.||..|| . .|| . .     .| |. ..|  .|. |   ||.|.| |.. . .  
sawpdhGapkeaytaldilkfces.y...kknvlvhcsaGvGrtGtlvaikyGiqlcskk.....kvtdllsivlpvrqcryGavqdeqqliylllcvtk

AL
.|
gl

subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 1236-1332 5.3e-20 66.2 In-house 49-144 (310) alignment
Range on Protein: 1236-1332
Range on HMM: 49-144/310.0
TQANRDKNRYRNITAYDHSRVVLQVNPEEGGcDYYNANYIAGARSPSDYIACQGPTNSSVDDFWRMVWQQKTQCIVMVTNLEEQGRMKCLKYWPDLA
 . .  |||| ..   | ||| |...    . ||  |||.      | .| .||| . .. |||||..|.... |... .  |.|| ||. ||| | 
ykkymhknrysdvvcldtsrvklkidksrye.dyihanyvktnylrstficsqgplqhtiidfwrmifqeraesilllckvgeegrpkcvgywpslg

subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 1248-1494 1e-18 62.5 In-house 27-263 (290) alignment
Range on Protein: 1248-1494
Range on HMM: 27-263/290.0
ITAYDHSRVVLQVNPEEGGCDYYNANYIAGArSPSDYIACQGP-------TNSSVDDFWRMVWQQKTQCIVMVTNLEEQGRM----KCLKYWPDlapgvs
..   ..||||..  .    ||  ||..  . .    |. | |        || . .|| |. | | . .||. . ||. .      | || |.      
vpLveatrvvLkgygkrfnddyiHAnrvtcp.nglrliltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCakYvpe......

addlRADElpKLQLGPYVVFFKERHEHKLWTQRVFELEHEGEGRMTVTQFHMTAWPDHGVPSEPSDLLYFRQAIRaafpNPTSPMLVHCSAGVGRSGTFI
    ...|  .|...   |  |.. ...   .|  ......|  .|||   .  | .  |. ..  ||   | ..    . ..|..|||  |. || .. 
....svge..elkfkgltvkCkskekeddvetRelvvkfddeeeftvtHsllkgWnklnvqedtktllsliqkvk....asktpvivHcvdGiSrsAala

AIDHMLQLILDEARAASdvpdVRDVVHGMRDRRNFMVQTEEQYIFIYFALEMALTAMQ
||.   |.| .   . .    ..||.. .| .|. ........ |.  .. . .. ..
aiilgyQkiaetsgsvk....ledvlkalrkqralaitsalelafvdagivllaievl

subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 1294-1493 3.5e-17 57.3 In-house 40-221 (255) alignment
Range on Protein: 1294-1493
Range on HMM: 40-221/255.0
SVDDFWRMVWQQKTQCIVMVTNLEEQGRMKCLKYWPdlapgvsaddLRADE---LPKLQlgpyVVFFKERHEHKLWTQRVFELEHEGEGRMTVTQFHMTA
.|| |.... |.||. .||.....|.|. || .|.|          |  ||   | ...    |.  |   .  | | ..     |     ||. .. . 
tvdkfyqtivqtktevvvmlcdfaeegvekcssyfp..........lekdeklkladvn....vtttkssadvvlrtleitstlgekkkthtvkhysykG

WPDHGVPSEPSDLLYFRQAIRAAfpnptSPMLVHCSAGVGRSGTFIAIDHMLQLILDEARAASDV-PDVRDVVHGMRDRRNFMVQTEeqyIFIYFALEMA
|...  | .. ..|.  ...| .      ...||||.|.||| .|. .. . | ..   . .. |  | . ... .| .|.  ..|    . . |.. | 
WieknaPelareilnilkvvrds.....ksvvvhCstGiGrsaafvlaelvyqkmirsldttetveldylslleelrskrkraihtP...lqlafsilmv

LTAM
|. .
ldlv

subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 1381-1490 7e-17 55.9 In-house 89-194 (440) alignment
Range on Protein: 1381-1490
Range on HMM: 89-194/440.0
MTVTQFHMTAWPDHGVPSEPSDLLYFRQAIRAAFP-NPTSPMLVHCSAGVGRSGTFIAIDHmlqlILDEARAaSDVPDVRDVVHGMRDRRNFMVQTEEQY
 |. |.|. .|||.|||   . .| . | .  .      .|.|||||||.||.|  ||.|     || ||.  ||  |.  ..  ||. |  |||| |||
rtlkqyhyqgwpdkgvpkfagpvlkmiqdvnesqekagngpllvhcsagagrtgviiavds....ilreakr.sdqidifsfinsmrnnrpqmvqtpeqy

IFIYFALEMAL
 |.. |.  .|
afvheavlegl

subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 1384-1487 1.3e-16 55.3 In-house 218-341 (350) alignment
Range on Protein: 1384-1487
Range on HMM: 218-341/350.0
TQFHMTAWPDHGVPSEPSDLLYFRQ----------AIRAAFPNPTSPMLVHCSAGVGRSGTFIAIDHMLQ--LILDEARA---ASDVP-DVRD----VVH
 |...  |.| ..  .| ..|   .          |      . .||.|||||||||| ||....|..|.  .||.. .     .||.  .||    .| 
yqlqvknWkDlslllnPesilqalevkndliddlfaeshldnarsspilvhCsaGvGrtGtlvtlDsllsdfeilenltkesrkldvaaktrDlisiivn

GMRDRRNFMVQTEEQYIFIYFALE
 .| .|  |||. .|.|||| || 
elrkqrismvqnldqfifiYeall

Guanylate_kin Guanylate kinase 446-520 3.2e-15 43.4 Pfam-A 14-87 (183) alignment
Range on Protein: 446-520
Range on HMM: 14-87/183.0
GTQASLRSVTQQQPLLFYdASVPLTTRTPEAGEVQGQTYHFVSPQLFHFFLANKHLAEWGQYLDHYYGSLKRSIE
|..     . ...|  |   ||. |||.. .|||.|. |.||| . ..   ..... |.... ...||. . .||
GkstlkkaLldelpekfg.isvshtTrdkrkgevdGkdYfFvskeelekdiskneflEaaefsgnlygtsveeie

subfamily_hpo-7_pd Subfamily hpo-7 1294-1503 2.7e-14 47.7 In-house 46-238 (263) alignment
Range on Protein: 1294-1503
Range on HMM: 46-238/263.0
SVDDFWRMVWQQKTQCIVMVTNLEEQGRMKCLKYWPdlapgvsaddLRADELPKLQlGPYVVFFKERHEHKLWTQRVFELEHEGEGRMTVTQFHMTAWPD
 .| |.... |.||. .||... .|.|. || .|.|          |  ||  ||.    |.  |  ..  | |. . .   |     ||...  . |..
tidkfyqtivqtktevvvmLcDfneegvekcssyfP..........lekdekqkla.nvnvcttkvqsdvllktlellstlgeKkkthtvkhysykgWie

HGVPSEPSDLLYFRQAIRAAfpnptSPMLVHCSAGVGRSGTFIAIDHMLQLILDEARAASDV-PDVRDVVHGMRDRRNFMVQTEeqyIFIYFALEMALTA
.  | .. . |.  .. |        .. ||||.|.|||  |  .. . | ..   . .| |  | . ... .| .|.  ..|    . . |.. | |. 
kndpelareilnilkvarns.....kslvvhcstGiGrsaafsvaElvyqkmirsldttstveldylsLleelrssrkraihtP...mqLafsilmvLdf

-MQATDKADLKM
 ...  | .|. 
vlnnfakgelea

subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 1409-1485 6.6e-14 46.4 In-house 220-290 (297) alignment
Range on Protein: 1409-1485
Range on HMM: 220-290/297.0
AIRAAFPNPTsPMLVHCSAGVGRSGTFIAIDHMLQLIldeaRAaSDVPDVRDVVHGMRDRRNFMVQTEEQYIFIYFA
..||. | .. ..||||||||||||  .  | .|. .    |    .|||. ... .|..|  .||| ||. ..| |
slraemprna.yllvhcsaGvGrsGvvvlsdvilakl....rk.kripdvaailsilreqrarlvqtleqfellyda

subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 1241-1331 1.1e-13 45.2 In-house 50-156 (349) alignment
Range on Protein: 1241-1331
Range on HMM: 50-156/349.0
DKNRYRNITAYDHSRVVLQVNPEE-----------GGC---DYYNANYIAGARSPSD--YIACQGPTNSSVDDFWRMVWQQKTQCIVMVTNLEEQGRMKC
 ||||..|  |.||||.|.  ..             ..   || ||||.  .|   .  ||| | |  |.||||....  .. . .. ... .|..  ||
aknrykdilPyehsrvklkkslksskvikastsesdsgklddyinanylkltrisvekkyiatqaPlPstvddfykvillngvklvlsLnddkelslekc

LKYWPDL
 .|| .|
diywqel

subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 1238-1486 2.2e-13 44.5 In-house 46-275 (303) alignment
Range on Protein: 1238-1486
Range on HMM: 46-275/303.0
ANRDKNRYRNITAYDHSRVVLQvnpeegGCDYYNANYIAGArSPSDYIACQGPTNSSVDDFWRMVWQQKTQCIVMVTNLEEQGRMKCLKYWPDlapgvSA
 | ||||. ..   |||.| |          |  |.|.    |    |  | | . .  |||.|. .|| .|....    |  ..     .|        
knmdknrfvdvicldhskvkls......dssyihasyleld.sskkailtqlplshtaadfwqmiieqkvkcvlllltdseydklggdsvfpr.....nq

DDLRADElPKLQLGPyvvfFKERHEHKLWTQRVFELEhEGEGRMTVTQFHMTAWPDHGVPSEPSD----LLYFRQAIRAAFPnPTSPMLVHCSAGVGRSG
| |. .|   ...|     ||.    . |. .|  .  .|. .  .   |  |||   .||. |      ..  |..   .  ...| .    .|.||.|
dflkfee.rsirvge....fkrvelgdgwvlkvlsvs.ngdyksflhvhhykawphnsipsdgspkfvkqiwqlqsvlrkys.dstptvymslsgcgrag

TFIAIDhMLQLILDEARAASDVPDvrdVVHGMRDRRNFMVQTEEQYIFIYFAL
||  ..   .| | . .|. |.     ..  .|. |   ||   |. ..|  |
tfalfe.tahlslhseqasldlvk...clenvrngrlhavqnlsqfsvvytll

Ank_2 Ankyrin repeats (3 copies) 144-213 3e-13 38.0 Pfam-A 15-80 (89) alignment
Range on Protein: 144-213
Range on HMM: 15-80/89.0
ILLRAKADGDCqdvmGNSALHTAAHFGHVDVVHLLLQYQVDCHRLNNQAENALFTAVRQNQAACVRLFVK
.|| ..|| |     |...|| ||  |....| |||... |.   ... ..||. |||.... .|.| ..
lLlekgadvdl....getpLhlAaeagnleivklLleagadvnakdkegntaLhlAvrnghlelvklLle

subfamily_CG42327_pd Subfamily CG42327 1417-1488 7.4e-13 42.8 In-house 246-313 (319) alignment
Range on Protein: 1417-1488
Range on HMM: 246-313/319.0
PTSPMLVHCSAGVGRSGTFIAIDHMLQLiLDEARAASDVPDvrdVVHGMRDRRNFMVQTEEQYIFIYFALEM
   |. |||| ||||.|. || |  ..  |.|.. . |.|.   .|. .|  |   |.| ||| |||  | .
sqGPlvvhcsdGvGrtGlviasdiairs.leeskrsvdiPq...lvssvrrdrasavltkeqyefiykvlse

Ank_4 Ankyrin repeats (many copies) 159-211 1.5e-12 35.8 Pfam-A 1-53 (54) alignment
Range on Protein: 159-211
Range on HMM: 1-53/54.0
GNSALHTAAHFGHVDVVHLLLQYQVDCHRLNNQAENALFTAVRQNQAACVRLF
|..||| ||..|....|.|||.. .|..|.... ..||  |.. ..  ...|.
gltaLhyaaisgrlelvklLlekgidinrtdesGntaLhiAalrgnieilklL

subfamily_Cele-PTP-12_pd Subfamily Cele-PTP-12 1238-1323 3.2e-12 40.6 In-house 33-117 (332) alignment
Range on Protein: 1238-1323
Range on HMM: 33-117/332.0
ANRDKNRYRNITAYDHSRVVLqvNPEEGGCDYYNANYIAGARSPSDYIACQGPTNSSVDD-FWRMVWQQKTQCIVMVTNLEEQGRMK
 | | ||   . ..||||| |   |..|  |.|||... |    | || .| | |   .  ||||| ..|   |... ...|. . |
nnmdmnriphlycfdhsrvel..apqdgkddfynaswvdgyskksayifaqapfndhteyvfwrmvserkpsmilvfgdidekqkrk

subfamily_Sponge-PTP-7_pd Subfamily Sponge-PTP-7 1421-1490 1.3e-11 38.8 In-house 1-65 (69) alignment
Range on Protein: 1421-1490
Range on HMM: 1-65/69.0
MLVHCSAGVGRSGTFIAIdhmlqlILDEARAASD-VPDVRDVVHGMRDRRNFMVQTEEQYIFIYFALEMAL
|.||||.| ||.||||||      ... ||  |. . |. . |  ||  |  ||  | .||||. ||  ||
mvvhcssgtgrtgtfiai......mvemarikseklvdifnnvqymrkcrpmmvmneieyifihdalveal

Ank_5 Ankyrin repeats (many copies) 146-199 3.4e-11 31.2 Pfam-A 2-56 (56) alignment
Range on Protein: 146-199
Range on HMM: 2-56/56.0
LRAK-ADGDCQDVMGNSALHTAAHFGHVDVVHLLLQYQVDCHRLNNQAENALFTA
|..  || ...|  ||..||.||. |...|| |||....|..  ... ..||  |
lehgpadvnatdeggntpLhlAakggalevvrlLlapgadlnlrdsdgltaldlA

subfamily_Sponge-PTP7_pd Subfamily Sponge-PTP7 1423-1490 7.1e-11 36.3 In-house 2-64 (69) alignment
Range on Protein: 1423-1490
Range on HMM: 2-64/69.0
VHCSAGVGRSGTFIAIdhmlqlILDEARAASD-VPDVRDVVHGMRDRRNFMVQTEEQYIFIYFALEMAL
||||.| ||.||||||      ... ||  |. . |. . |  ||  |  ||  |..|.||. ||  ||
vhcssGtGrtGtfiai......mvemarikseklvdifnnvqymrkcrpmmvmneneymfihdalveal

PDZ PDZ domain (Also known as DHR or GLGF) 542-616 9.6e-10 28.7 Pfam-A 6-79 (81) alignment
Range on Protein: 542-616
Range on HMM: 6-79/81.0
RNAENVFGFGIHGGTDHR-NLPFIAHIADVaYAPSSPNrIAHGDAILRINDESTLTWSSEQCVQAITSSLNVLTLV
.. .. .|| ..||.|.| .  |....     |.   . .  || ||..|.... ..| ...||||... ...||.
kekrgglGfslkggsdkrdkgifvsevvpg.gaaeadg.lkeGDkIlsvNgvdvenvshdeavqaikgkkgevtLt

subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 1214-1319 2.1e-09 31.2 In-house 25-130 (302) alignment
Range on Protein: 1214-1319
Range on HMM: 25-130/302.0
EGGLQTEFSRLQSVGLRHKSCAT-QANRDKNRYRNITAYDHSRVVLQVNPEeggcDYYNANYIAGARSPSDYIACQGPTNSSV---DDFWRMVWQQKTQC
.. ...|| .....     .| . ..| .||.  .. ..|. .| |. .|.    .|.||  .         |  | |. .|.   ..|||||.|.| . 
taevkkefkkidtmkvdlekCkafkknlkknqsedvpildsnlvkleaepd....syvnaskvevPeltrsiilaQlpkvdsedsveeFWrmvfqekivs

IVMVTNLEEQ
.|..   || 
vvilvgeeel

PDZ PDZ domain (Also known as DHR or GLGF) 342-421 6e-09 26.1 Pfam-A 4-81 (81) alignment
Range on Protein: 342-421
Range on HMM: 4-81/81.0
VRRGADGLLGFSVVGGIEQDaLPAIALSD-AHSPHYEGQGyqLREGDELLAVDGHPVAGLSHAGVVDLFRQCESRVSLLIL
. .   | ||||..|| ...  . |  |.  . .  | .|  |.||| .|.|.| .|...||. .|.. ... . |.|.||
lekekrgglGfslkggsdkr.dkgifvsevvpggaaeadg..lkeGDkIlsvNgvdvenvshdeavqaikgkkgevtLtil

subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 1418-1486 6.3e-09 29.6 In-house 265-340 (349) alignment
Range on Protein: 1418-1486
Range on HMM: 265-340/349.0
TSPMLVHCSAGVGRSGTFIAIDHMLQLILDEA--RAASDVPD-VRDV----VHGMRDRRNFMVQTEEQYIFIYFAL
.|..||||||| ||.|... .| .|...          ...   .|.    |  .|  |  |||   |.|.|| ||
lstllvhcsaGcGrtGvlvtldlllsileplqnesnkiklqallkDlisiivnelrkqrismvqnlaqfiaiyeal

subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 1383-1500 7.5e-09 29.6 In-house 192-298 (310) alignment
Range on Protein: 1383-1500
Range on HMM: 192-298/310.0
VTQFHMTAWPDHGVPSEPSDLLYFRqaIRAAFpnPTSPMLVHCSAGVGRSGTFIaidhMLQLILDEARAASDVpDVRDVVHGMRDRRNFMVQTEEQYIFI
|.  .   ||| ||| |    .  |  . |       | .||||||..| .. .     |.| .| ..    | |. .|.  .. .|   .||| ||..|
vslikwpnwpdrgvpdekchtvpqr..llaqv..rhgpcvvhcsagkdrlyvvv....alklkidkldrglkv.daeevktellksraiciqtelqylii

YFAlEMALtAMQATDKAD
 .   ... |   |..|.
drv.riif.argetevae

Ank Ankyrin repeat 159-189 1.2e-08 22.6 Pfam-A 2-32 (33) alignment
Range on Protein: 159-189
Range on HMM: 2-32/33.0
GNSALHTAAHFGHVDVVHLLLQYQVDCHRLN
|...|| ||. |...|| |||..  | .  .
GfTPLHlAalrgnlevvklLlsqGAdlnaqd

subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 1238-1313 2e-08 28.1 In-house 36-116 (347) alignment
Range on Protein: 1238-1313
Range on HMM: 36-116/347.0
ANRDKNRYRNITAYDHSRVVLQVNP-EEGGC----DYYNANYIAGARSPSDYIACQGPTNSSVDDFWRMVWQQKTQCIVMV
 . .||| ..    | .||||  .  . . .     | || .|    .  .||  | |  ..| |||.||   |   .| .
kslsknrskdvklidatrvvlspeksknsraddvetyinashikfdnaskeyiltqyplpdtvrdfwkmvsvtkvtqvvti

subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 1386-1488 2.2e-08 27.9 In-house 186-283 (302) alignment
Range on Protein: 1386-1488
Range on HMM: 186-283/302.0
FHMTAWPDHGVPSEPSDLLYFRQAIRAAFPNPTSPMLVHCSAGVGRSGTFIAIDHMLQLILDEaraasDVPDVRDVVHGMRDRRNFMVQTEEQYIFIYFA
 ..| |... || . ..|    . . |   . ......    |.|| |.|..    .. . ..     . | . ..|. .|  |  .|.. .||...| |
yvltnWkqkkvpvkyaeliktaakvfakkikadentvivSknGaGRagafltlavaveklqkg.....kepnikeivksiRsqRpravdslkQyvslyia

LEM
| .
lll

subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 1220-1280 3e-08 27.4 In-house 27-88 (440) alignment
Range on Protein: 1220-1280
Range on HMM: 27-88/440.0
EFSRLQSvGLRH-KSCAT-QANRDKNRYRNITAYDHSRVVLQVNPEEGGCDYYNANYIAGARS
|.| | | || .    |.   |. ||||||| |||||||.|.        || || ||.|  |
ewsllps.glsqpsdiaslpnnkvknryrnilaydhsrvmleevkgvpdsdyinasyingies

Ank_3 Ankyrin repeat 159-184 4.6e-08 21.1 Pfam-A 2-27 (30) alignment
Range on Protein: 159-184
Range on HMM: 2-27/30.0
GNSALHTAAHFGHVDVVHLLLQYQVD
||..||.||..|....|..||.. .|
GnTpLhlAasngrielvkyLlengad

subfamily_eak_pd Subfamily eak 1237-1410 6.5e-08 26.3 In-house 50-207 (332) alignment
Range on Protein: 1237-1410
Range on HMM: 50-207/332.0
QANRDKNrYRNITAYDHSRVVLQVNpEEGGCDYYNANYIAGARSPSDYIACQGPTNSSVDDFWRMVWQQKTQCIVMVTNLEEQGRMKCLKYWPDLApgvs
  . ..|   .|  ||.  | |          | ||  .  .     ||    . .. |  ||.|| .||. .||.. .  |..  |  ||.|| .    
leavnrn.vvkivpydrylvrltss.qlnrlGyinaslaefsevGrkyiltGiasedkvfafwqmvleqkspaivqlledvelkleksdkyfpdkt....

addlRaDelpKLQLGPYVVFFKERHEHKLWTQRVFELEHeGEGRMTVTQFHMTAWPDHGVPSEpSDLLYFRQAI
    | .   .|. | . |  ||  ...    | .||.  |.    |  ...  | .  .|    |.| .|...
....r.e...elkfGildverkefvkrniletrllelsk.GnethrvlhykvfGwtettlpky.edflalrkvm

0038934 (Phosphotyrosine protein) phosphatases II 1385-1438 1.7e-07 26.6 In-house 81-135 (194) alignment
Range on Protein: 1385-1438
Range on HMM: 81-135/194.0
QFHMTAWPDHGVPSEPSDLLYFRQAI-RAAFPNPTSPMLVHCSAGVGRSGTFIAI
...   .||.|..   . || | ... .    .|    .||| ||.||.||..| 
eylklpfpddgtvPsleillrfldlvdeflnedpggvvaVHCkaGlgRtGtlvaa

subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 1232-1279 3.7e-07 24.0 In-house 32-78 (244) alignment
Range on Protein: 1232-1279
Range on HMM: 32-78/244.0
KSCATQANRDKNRYRNITAYDHSRVVLQVNPEEgGCDYYNANYIAGAR
 ..   ||  |||| ||  .|..||.|  . .| |.|| ||||| |..
tnavlsanatknryinilpfdetrvilssskke.gsdyinanyiqgsq

subfamily_Sponge-PTP3_pd Subfamily Sponge-PTP3 1226-1289 3.8e-07 24.2 In-house 35-95 (95) alignment
Range on Protein: 1226-1289
Range on HMM: 35-95/95.0
SVGLRHKSCATQANRDKNRYRNITAYDHSRVVLQVNPEeggCDYYNANYIAGARSPSDYIACQG
. |  .   ...||  |||. ||  || .||||  . .    || || .. |      |||.||
tsgapytvgsseanipknrflnifpydatrvvlttkrd...sdyinacfvdgyarkncyiaaqg

subfamily_Sponge-PTP-2_pd Subfamily Sponge-PTP-2 1237-1402 9.8e-07 21.8 In-house 25-160 (169) alignment
Range on Protein: 1237-1402
Range on HMM: 25-160/169.0
QANRDKNRYRNITAYDHSRVVLQVNPEEGGCDYYNAnyiagarspsdyiacqgptnssvddfwRMVWQQKTQCIVMVTNLEEQGRMKCLKYWPDLAPGVS
 .|  |||     |  | || ||   |. |.|| ||                           ||.|.  .  ||.. . ...  .   |   .| | | 
tcnetknrpagplapshtrvklqrvmedlgsdyina...........................rmiwetnasvivvlgdtddknnfwpekedyqlhpavi

ADDLRADELpklqlgpYVVFFKE----RHEHKLWTqrVFELEHEGEGRMT--VTQFHMTAWPDHGVPSEPSD
  .  .| |       ||   |     .  . |.   |  . |. .  .|  .. .| ..||. |||  |  
lgewytdsl.......yvrtdkvhantsgveglfe..vsmvihsydddvteklsllhystwpqngvpqspvh

subfamily_Sponge-PTP2_pd Subfamily Sponge-PTP2 1237-1402 1.5e-06 21.1 In-house 24-159 (169) alignment
Range on Protein: 1237-1402
Range on HMM: 24-159/169.0
QANRDKNRYRNITAYDHSRVVLQVNPEEGGCDYYNAnyiagarspsdyiacqgptnssvddfwRMVWQQKTQCIVMVTNLEEQGRMKCLKYWPDLAPGVS
 .|  |||     |  | || ||   |. |.|| ||                           ||.|.  .  ||.. . ...  .   |   .| | | 
tcnetknrpagplapshtrvklqrvmedlgsdyina...........................rmiwetnasvivvlGdtddknnfwpekedyqlhpavi

ADDLRADELpklqlgpYVV----FFKERHEHKLWTQRVFELEHEGEGRMTVTQFHMTAWPDHGVPSEPSD
  .  .| |       ||       .    . |.   .   ... .    .. .|...||. |||  |  
lGewytdsl.......yvrtdkvhpntsgveglfevslvihsydddvteqlsllhystwpqngvpqspvh

subfamily_eak_pd Subfamily eak 1416-1486 1.8e-06 21.6 In-house 234-301 (332) alignment
Range on Protein: 1416-1486
Range on HMM: 234-301/332.0
NPTSPMLVHCSAGVGRSGTFIAIDHMLQLILDEARaasDVPDVRDVVHGMRDRRNFMVQTEEQYIFIYFAL
 |.   .. .. |  |.|.|. || ...|| .  .   ..  | |..  ....|.  | .. |. ||| ..
ppsfapiiqsarGsaraGvfvvidllirlidnkkk...nlysvedlilkvkskrihsvlvalqhsfiyeiv

subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 1283-1334 2.8e-06 21.6 In-house 6-57 (199) alignment
Range on Protein: 1283-1334
Range on HMM: 6-57/199.0
DYIACQGPTNSSVDDFWRMVWQQKTQCIVMVTNLEEQGRMKCLKYWPDLAPG
 |||.| |   .. |||.|||.  .  |||| . . .       |||    |
ryiatqhplretmadfwqmvwetgsghivmvnddqknkeadypfywpttesg

subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 1283-1334 2.8e-06 21.6 In-house 5-56 (198) alignment
Range on Protein: 1283-1334
Range on HMM: 5-56/198.0
DYIACQGPTNSSVDDFWRMVWQQKTQCIVMVTNLEEQGRMKCLKYWPDLAPG
 |||.| |   .. |||.|||.  .  |||| . . .       |||    |
ryiatqhplretladfwqmvwetgsghivmvnddqknkeadypfywpttesg

PTEN_1 1380-1437 5.1e-06 21.4 In-house 92-149 (196) alignment
Range on Protein: 1380-1437
Range on HMM: 92-149/196.0
RMTVTQFHmTAWPDHGVPSEPSDLLYFRQAIRAAFPNP-TSPMLVHCSAGVGRSGTFIA
.. |.. |   ..|||.||  . .   ...| ..  .|     |||| ||.||||| .|
ksgveylh.fpieDhgapslselfdicksfiewllsdpngnvVlVHCkaGlgRsGtvva

subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 1283-1329 7.9e-06 19.4 In-house 237-280 (440) alignment
Range on Protein: 1283-1329
Range on HMM: 237-280/440.0
DYIACQGPTNSSVDDFWRMVWQQKTQCIVMVTNLEEQgrmKCLKYWP
 .|| | | .|.| ||||.| . .   |.|. .|...    |  |||
afiatqmpldstvldfwrlvhdyristiimlnqlndk...tcsiywp