Gene expression:
Classification
Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.
Protein sequence
Domains
Summary
Details
| Domain | Domain Description | Range | Significance | Score | Source | Profile Range (length) | Alignment | ||
|---|---|---|---|---|---|---|---|---|---|
| 0046845 | (Phosphotyrosine protein) phosphatases II | 265-495 | 2e-50 | 167.2 | In-house | 33-275 (284) | alignment | ||
Range on Protein: 265-495
Range on HMM: 33-275/284.0
REPRILPSVTTRIQLDRPPGA-KISGFINANAVRGFQ----GNPMRFIVTQAPLSGfesgrvgTQVAFWSMVYQYQAPVVIMLIEPQPH---RCTRYWPV
| . ||| .|. |....| . |..|||. |.|.. ....||.||.||.. | || ||......|..|| |. | .|||
RykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpn.......tvedFwrmvweqnvrvIVmltelvengrekcaqYwpl
PDGNLRSGPFEVRHHGFDKHRGFLVSSLSLTL---RGKTHRFQHICLSGWNEHGLPRSSKSVIALLRYLRNL----KVRGPIVVHDDRGLGPSGVFVASD
.. |. |.| |. ... .. | |.|| |.... .|.. .| .|| | |.......||..|.| . ||||||. |.| .|.|.| |
egevltygdftvtllseevkddytvrtleltnlgytgesrtvthfhytswpdhgvppspedlleflrlvrellenlpgggpivVHCsaGvgRtGtfiald
YCIDQAQAG----KVDVMQAVYTLRQDRAALVESRAEYQYIHRLVLGYLD
....| ... .||| .||. ||. | |.. . |.......| ||
llleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyealleylk
|
|||||||||
| 0051299 | (Phosphotyrosine protein) phosphatases II | 264-494 | 1.2e-49 | 164.7 | In-house | 53-286 (288) | alignment | ||
Range on Protein: 264-494
Range on HMM: 53-286/288.0
LREPRILPSVTTRIQLDRPPGAKISGFINANAVRGFQGNPMrFIVTQAPLSgfesgrvGTQVAFWSMVYQYQAPVVIMLIEPQPHR---CTRYWPVpDGN
| . ||| .|..| ..| |..|||. ..|.. . ||.||.||. .| || ||.... .|..|| ... . | .||| .|
nRysdilpydhsRVkLsvldgvegsdYinAsyidgynlkrk.fIatqgPlp.......ntvedFWrmvweqnvrvIvmltklvelgrekcaqYwpl.ggs
LRSGPFEVRHHGFDKHRGFLVSSLSLT------LRGKTHRFQHICLSGWNEHGLPRSSKSVIALLRYLRNL--KVRGPIVVHDDRGLGPSGVFVASDYCI
| |.. |. ... .. | | .| |.... .|.. .| .|| | | ......||..|. . ||.||| |.| .|.|.| |...
ltygditvtllseevlddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpdspellldflrlvrkalasgggpvvVHCsaGvgRtgtfialdlll
DQA-QAGKVDVMQAVYTLRQDRAALVESRAEYQYIHRLVLGYL
.| . |.|||..|| .||. | .|.. |.......| ||
eqlekeggvdvleavkrlreqRpgmvqtpeqyrfvyealleyl
|
|||||||||
| 0050432 | (Phosphotyrosine protein) phosphatases II | 265-496 | 5e-49 | 162.7 | In-house | 73-301 (308) | alignment | ||
Range on Protein: 265-496
Range on HMM: 73-301/308.0
REPRILPSVTTRIQLdrppGaKISGFINANAVRGFQ-GNPMRFIVTQAPLsgfesgrVGTQVAFWSMVYQYQAPVVIMLIEPQP---HRCTRYWPVP--D
| . ||| .|. | . . |..|||. |.|.. ..|..||.||.|| .| || ||.... .|..|| ... | .||| .
rykdilpydhsRVkl....d.egsdYInAsyvdgyssklprkfIatqgPl.......pntvedFwrmvweqnvrvIvmLtklvengrekcaqYwplelgg
GNLRSGPFEVRHHGFDKHRGFLVSSLSLTL--RGKTHRFQHICLSGWNEHGLPRSSKSVIALLRYLRNLKVRGPIVVHDDRGLGPSGVFVASDYCIDQA-
| |. |.| |.. ... .. | | || |.... .|.. .| .|| | | ......|...|. |||||| |.| .|.|.| |....|
gsleygkftvtllseevlddytvrtleltnlgdgesrtvthfhytnWpdhgvPpspeilldflelvrkslpggpivVHCsaGvGRtGtfialdllleqle
QAGKVDVMQAVYTLRQDRAALVESRAEYQYIHRLVLGYLDG
. |.||| .||..||. |. |.. |....|..| ||
keggvdvfeavkklReqRpgmvqtpeqylflyralleylkl
|
|||||||||
| DSPc_SM00195 | 263-494 | 4.6e-48 | 159.2 | In-house | 29-262 (263) | alignment | |||
Range on Protein: 263-494
Range on HMM: 29-262/263.0
ELREPRILPSVTTRIQLDRPPGAKISGFINANAVRGFqGNPMRFIVTQAPLsgfesgrVGTQVAFWSMVYQYQAPVVIMLIEPQP---HRCTRYWPVP-D
| ||| ||..|..... . | .|||| ..| .. ..|.||.|| | || ||.. . ....|| |.. .|.|||| .
knRyknilpydhtrVklkkeekkegsdYINAnyikga.nkkkkyIatQgPl.......pstvedFWrmvweekvkiivmlteeeengkekcdrywpeesg
GNLRSGPFEVRHHGFDKHR-GFLVSSLSLTLRG--KTHRFQHICLSGWNEHGLPRSSKSVIALLRYLRNLKV--RGPIVVHDDRGLGPSGVFVASDYCID
|. . | ..| .|.. . . |.|| | .|...... .|..||.| | |||..|||.... | |||||| . |.| .|.||. |....
gketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkkskstssgpivVhCsaGvgRtgtfvtidiils
QAQAG-KVDVMQAVYTLRQDRAALVESRAEYQYIHRLVLGYL
. ... |||. . | ||. |. .|.....|..|.. .| |.
kleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi
|
|||||||||
| PTPc_SM00194 | 263-494 | 4.6e-48 | 159.2 | In-house | 29-262 (263) | alignment | |||
Range on Protein: 263-494
Range on HMM: 29-262/263.0
ELREPRILPSVTTRIQLDRPPGAKISGFINANAVRGFqGNPMRFIVTQAPLsgfesgrVGTQVAFWSMVYQYQAPVVIMLIEPQP---HRCTRYWPVP-D
| ||| ||..|..... . | .|||| ..| .. ..|.||.|| | || ||.. . ....|| |.. .|.|||| .
knRyknilpydhtrVklkkeekkegsdYINAnyikga.nkkkkyIatQgPl.......pstvedFWrmvweekvkiivmlteeeengkekcdrywpeesg
GNLRSGPFEVRHHGFDKHR-GFLVSSLSLTLRG--KTHRFQHICLSGWNEHGLPRSSKSVIALLRYLRNLKV--RGPIVVHDDRGLGPSGVFVASDYCID
|. . | ..| .|.. . . |.|| | .|...... .|..||.| | |||..|||.... | |||||| . |.| .|.||. |....
gketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkkskstssgpivVhCsaGvgRtgtfvtidiils
QAQAG-KVDVMQAVYTLRQDRAALVESRAEYQYIHRLVLGYL
. ... |||. . | ||. |. .|.....|..|.. .| |.
kleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi
|
|||||||||
| Y_phosphatase | Protein-tyrosine phosphatase | 265-491 | 7.5e-46 | 151.8 | Pfam-A | 6-234 (235) | alignment | ||
Range on Protein: 265-491
Range on HMM: 6-234/235.0
REPRILPSVTTRIQLDRPPGAKIsgFINANAVRGFQgNPMRFIVTQAPLsgfesgrVGTQVAFWSMVYQYQAPVVIMLIEPQP---HRCTRYWP-VPDGN
| . ||| ||..|. .|.. .|||| |.|.. .. .||.||.|| | || ||.|.. |..|| . . | .||| ..
Rykdilpydktrvklkgsegpsd..YInAnyvkgyk.ekkkfIatQgPl.......kstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeees
LRSGPFEVRHH-GFD-KHRGFLVSSLSLTLRGKTH---RFQHICLSGWNEHGLPRSSKSVIALLRYLRNLK--VRGPIVVHDDRGLGPSGVFVASDYCID
|. | ..|. .. .. .. |.|. ... . ..... . .|..||.|.|.||.. |.| ... | .||.||| | | .|.||| |....
ltygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldille
QAQA-GKVDVMQAVYTLRQDRAALVESRAEYQYIHRLVL
|..| ..|||.|.| .||. |. .|.| ..|.......|
qleaeeevdvlqivkelRkqRpgmvqsleqYiflykail
|
|||||||||
| Y_phosphatase | Protein-tyrosine phosphatase | 265-491 | 7.5e-46 | 151.8 | In-house | 6-234 (235) | alignment | ||
Range on Protein: 265-491
Range on HMM: 6-234/235.0
REPRILPSVTTRIQLDRPPGAKIsgFINANAVRGFQgNPMRFIVTQAPLsgfesgrVGTQVAFWSMVYQYQAPVVIMLIEPQP---HRCTRYWP-VPDGN
| . ||| ||..|. .|.. .|||| |.|.. .. .||.||.|| | || ||.|.. |..|| . . | .||| ..
Rykdilpydktrvklkgsegpsd..YInAnyvkgyk.ekkkfIatQgPl.......kstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeees
LRSGPFEVRHH-GFD-KHRGFLVSSLSLTLRGKTH---RFQHICLSGWNEHGLPRSSKSVIALLRYLRNLK--VRGPIVVHDDRGLGPSGVFVASDYCID
|. | ..|. .. .. .. |.|. ... . ..... . .|..||.|.|.||.. |.| ... | .||.||| | | .|.||| |....
ltygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldille
QAQA-GKVDVMQAVYTLRQDRAALVESRAEYQYIHRLVL
|..| ..|||.|.| .||. |. .|.| ..|.......|
qleaeeevdvlqivkelRkqRpgmvqsleqYiflykail
|
|||||||||
| 0039614 | (Phosphotyrosine protein) phosphatases II | 265-497 | 5.1e-45 | 149.6 | In-house | 61-292 (297) | alignment | ||
Range on Protein: 265-497
Range on HMM: 61-292/297.0
REPRILPSVTTRIQLDRPPGA-KISGFINANAVRGFQGNPMRFIVTQAPLSGfesgrvgTQVAFWSMVYQYQAPVVIMLIEPQPHR--CTRYWPVPDGnl
| . ||| .|..| ..| | .|||. | |. ....||.||.||.. | || ||.... .|..|| .. .. | .||| |
rykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfIatqgPlpe.......tvedFwrmvweqgvtvivmLtklvelgrkcaqywpeegg..
RSGPFEVRHHGFDKHRGFLVSSLSLTLRGKTHRFQHICLSGWNEHGLPRSSKSVIALLRYLRNLK----VRGPIVVHDDRGLGPSGVFVASDYCIDQAQ-
. |.| |. ..... |. | |..| |... .|.. || .|| | |..... .|...|. ||..|| |.| .|.|.| .....| .
tygdftvtllkvehldgytvrtlevtnngesrtvthfqytgwpdhgvppslellleflelvrealaelpkggpvlVHCsaGvgRtGtfiaaylmleqlek
AGKVDVMQAVYTLRQDRAALVESRAEYQYIHRLVLGYLDGK
|.||| .|| .||. | |.. |.......| .| |
eggvdvleavkelreqRpgavqtpsqyrflydallellkrk
|
|||||||||
| 0040438 | (Phosphotyrosine protein) phosphatases II | 266-494 | 1.1e-44 | 148.4 | In-house | 49-276 (317) | alignment | ||
Range on Protein: 266-494
Range on HMM: 49-276/317.0
EPRILPSVTTRIQLDRPPGAKISGFINANAVRGFqGNPMRFIVTQAPLSGfesgrvgTQVAFWSMVYQYQAPVVIMLIEPQPHR---CTRYWPVpDGNLR
| ||| .|..| ..| |..|||. | |. ...||.||.||.. | || ||.... |..|| |. . | .||| .. |
ypdilpydhsRVkLsplggdldsdYInAsyvdgp.nlkrkfIatqgPlpn.......tvedFwrmvweqgvtvivmLteleelgrekcaqYwpl.getlt
SGPFEVRHHGFDKHRGFLVSSLSLT--LRGKTHRFQHICLSGWNEHGLPRSSKSVIALLRYLRNL--KVRGPIVVHDDRGLGPSGVFVASDYCIDQAQ-A
|.| |.. ..... |. . | .. ..... .|.. || .||.| | ......|...|. . ||..|| |.| .|.|.| .....| .
ygdftvtllseeelagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfleavrealedpggpvlVHCsaGvgRtGtfiaaylmleqleke
GKVDVMQAVYTLRQDRAALVESRAEYQYIHRLVLGYL
|.||| .||..||. |. |.. . |.......| ||
ggvdveeavkelreqRpgavqtpeqyrflydalleyl
|
|||||||||
| 0036941 | (Phosphotyrosine protein) phosphatases II | 265-498 | 7.3e-44 | 145.6 | In-house | 44-281 (297) | alignment | ||
Range on Protein: 265-498
Range on HMM: 44-281/297.0
REPRILPSVTTRIQLdrppGAKISGFINANAVRGFqGNPMRFIVTQAPLSgfesgrvGTQVAFWSMVYQYQAPVVIMLIEPQPH---RCTRYWPVP-DGN
| . ||| ||..| . |..|||. | |. . ...||.||.||. .| || ||.... .|..|| |. . | .||| ..
RykdilpydhtRVkl....ddegsdYinAsyvdgy.dlkrkfIatqgPlp.......ntvedFWrmvweqnvtvIvmltelvelgrekcaqywpleeges
LRSGPFEVRHHGFDK--HRGFLVSSLSLTL--RGKTHRFQHICLSGWNEHGLPRSSKSVIALLRYLRNLK----VRGPIVVHDDRGLGPSGVFVASDYCI
| |.| |. .... . .. . | .| |.... .|.. || .||.| | .|........|. ||..|| |.| ||.|.| |...
ltygdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfielvrkvlkllpsggpvlVHCsaGvgRsgtfiaadlml
DQAQ----AGKVDVMQAVYTLRQDRAALVESRAEYQYIHRLVLGYLDGKD
.| . |.||. .|| .||. |. |.. |.......| .| |.
qqledklkeggvdileavkklReqRpgavqtleqyrflyeallellkkkl
|
|||||||||
| 0047943 | (Phosphotyrosine protein) phosphatases II | 265-494 | 8.9e-44 | 145.4 | In-house | 43-272 (273) | alignment | ||
Range on Protein: 265-494
Range on HMM: 43-272/273.0
REPRILPSVTTRIQLdrppGAKISGFINANAVRGFQGNPMrFIVTQAPLsgfesgrVGTQVAFWSMVYQYQAPVVIMLIEPQPH---RCTRYWPVPDG--
| . ||| .|. | | . |..|||. |.|.. .. ||.||.|| .| || ||......|..|| |.. | .||| |
rykdilpydhsrvkl....gdggsdyinAsyvdgynlkrk.fiatqgPl.......pntvedfwrmvweqnvrviVmLtelvelgrekcaqYwpleggel
NLRSGPFEVRHHGFDKHRGFLVSSLSLTL--RGKTHRFQHICLSGWNEHGLPRSSKSVIALLRYLRN----LKVRGPIVVHDDRGLGPSGVFVASDYCID
|. |.| |.. . ... .. | | || |... .|.. || .|| | | .|.. .....|. |. ||.||| |.| .|.|.| |...|
sltygkftvtllseetkddytvrtleltnlgtgesrtvthfhytgwpdhgvppslesllefielvrkalealpsngpvvVHCsaGvgRtgtfialdllld
QA-QAGKVDVMQAVYTLRQDRAALVESRAEYQYIHRLVLGYL
| |.||| .||. ||. | |.. |.......| ||
qlekeggvdvleavkllrsqRpgmvqtpeqyrflyealleyl
|
|||||||||
| 0045450 | (Phosphotyrosine protein) phosphatases II | 265-494 | 7.7e-42 | 139.5 | In-house | 60-304 (307) | alignment | ||
Range on Protein: 265-494
Range on HMM: 60-304/307.0
REPRILPSVTTRIQLDRPPGA-KISGFINANAV--------RGFQGnPMRFIVTQAPLSGfesgrvgTQVAFWSMVYQYQAPVVIMLIEPQPH---RCTR
| . ||| ||..| ..| . |..|||. | |. ...||.||.||.. | || |..... |..|| |. .. | .
rykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydl.krkfIatqgPlpe.......tvedFwrmlweqgvtvivmltelvelgrekcaq
YWPVPDGNLRSGPFEVRHHGFDKHRGFLVSSLSLT---LRGKTHRFQHICLSGWNEHGLPRSSKSVIALLRYLRN----LKVRGPIVVHDDRGLGPSGVF
||| .. | |.| |. ..... |. | | .| |.... .|.. || .||.| | ..........|. |. ||..|| |.| .|.|
ywPdegeeltygnftvtllseehldgytvrtlevtdldgtgesrtvthfhytgwpdhgvppsfeelldfieevrkaleelpkggpvlVHCsaGvgRtGtf
VASDYCIDQAQAGK----VDVMQAVYTLRQDRAALVESRAEYQYIHRLVLGYL
.| .....| .... ||. .|| .||. | |.. |.......| .|
iaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyeallell
|
|||||||||
| 0040439 | (Phosphotyrosine protein) phosphatases II | 265-494 | 8.7e-42 | 138.8 | In-house | 16-246 (249) | alignment | ||
Range on Protein: 265-494
Range on HMM: 16-246/249.0
REPRILPSVTTRIQLDRPPGAKISGFINANAVRGFQgNPMRFIVTQAPLSGfesgrvgTQVAFWSMVYQYQAPVVIMLIEPQPH---RCTRYWPVpDGNL
| | ||| .|..| || |..|||. . |.. ..|||.||.||.. | .|| |..... |..|| ..... | .||| .| |
rypdilpydhsrvklsilpglflsdyinAsyidgyy.ikrrfiatqgPlpe.......tvedfwrmlwelgitvivmLtslvelgrekcaqywpl.ggsl
RSGPFEVRHHGFDKHRGFLVSSLSLT--LRGKTHRFQHICLSGWNEHGLPRSSKSVIALLRYLRNLK----VRGPIVVHDDRGLGPSGVFVASDYCIDQA
| | |. .... .. | | || |.... .||. .| .||.| | ..........|. ||..|| |.| .|.|.| .....|
eygdftvtllsvevkddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaaylmleql
-QAGKVDVMQAVYTLRQDRAALVESRAEYQYIHRLVLGYL
..||. .|| .||. | |.. |.......| .|
ekelgvdleeavkllrsqRpgavqnpeqyrflyeallell
|
|||||||||
| subfamily_Choan-PTP-2_pd | Subfamily Choan-PTP-2 | 266-496 | 1e-41 | 137.7 | In-house | 26-266 (270) | alignment | ||
Range on Protein: 266-496
Range on HMM: 26-266/270.0
EPRILPSVTTRIQLDRPPGAKISGFINANAVRGFQGNPMRFIVTQAPLSgfesgrvGTQVAFWSMVYQYQAPVVIM---LIEPQPHRCTRYWPVPDGN--
|||| .||..|.. ... .|||| ||||.|.. ..| ...|| | .|| |... ... ..| | | ..| |||| ..
yadiLPsPatRvrleeleedsataYinAnyvrGfdgekkkYiaamgPlp.......ttlksfwrmiweekvtaivmttgleEkgrkkCerYWpaepkekv
-LRSGPFEVRHHGFDKHRGFLVSSLSLTLRGKTHRFQHICLSGWNEHGLPRSSK------SVIALLRYLRNLKVRG----PIVVHDDRGLGPSGVFVASD
|. | .|. |..|... | |. .|...| | |..|| ||.. .....|| .|. . . |..||. |.| .|...| |
kledgkikvlalseekeegyiltrlrleekgeerrlvHfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkaePllvHcsaGvgRtGtlialD
YCIDQA-QAGKVDVMQAVYTLRQDRAALVESRAEYQYIHRLVLGYLDG
... . .||||.. . ||.|| |||. .|..... |. | .
iavrlLeetkkvdvlaiieelRkdRmalvqhpeqyeflykavveyaer
|
|||||||||
| 0043336 | (Phosphotyrosine protein) phosphatases II | 265-493 | 1.4e-41 | 138.2 | In-house | 50-276 (278) | alignment | ||
Range on Protein: 265-493
Range on HMM: 50-276/278.0
REPRILPSVTTRIQLDRPPGAKISGFINANAVRGFQgNPMRFIVTQAPLSGfesgrvgTQVAFWSMVYQYQAPVVIMLIEPQPHR---CTRYWPvpDGNL
| . ||| .|..|. .| |..|||. | |.. |..||.||.||.. | || ||.... ....|| |. . | .||| .| |
rykdilpydhsrvklsllggdldsdYinAsyvdgyn.vprkfiatqgPlpe.......tvedFwrmvwelgvttivmLtelvelgrvkcaqYwp..ggsl
RSGPFEVRHHGFDKHRGFLVSSLSLT--LRGKTHRFQHICLSGWNEHGLPRSSKSVIALLRYLRNL--KVRGPIVVHDDRGLGPSGVFVASDYCIDQA-Q
. |.| |. ..... .. | | .| |... .|.. || .||.| | .... .|...|. . ||..|| |.| .|.|.| .....|.
tygdftvtllkeehlddytvrtlevtnlgdgesrtvthyhylgwpdhgvpeslsllldflkavrealedsngpvlVHCsaGvgRTGtfialyllleqlek
AGKVDVMQAVYTLRQDRAALVESRAEYQYIHRLVLGY
|.||. .|| .||. |. |.. |.......| |
eggvdleeavkelreqRpgavqtpsqyrflyealley
|
|||||||||
| subfamily_PTPN5_RR_pd | Subfamily PTPN5_RR | 236-494 | 2.2e-39 | 130.2 | In-house | 4-268 (274) | alignment | ||
Range on Protein: 236-494
Range on HMM: 4-268/274.0
ITSLQDDFRTLPLHLASSKSLGEHLLRELREPRILPSVTTRIQLDRPP-GAKISGFINANAVRGFQGNPMRFIVTQAPLSgfesgrvGTQVAFWSMVYQY
..|...| ||| . . | ||| ..|. | . .. | .|||| ..|.... .. || ||. | || |.||
fkdlekeflelPlnfdqeeldvfgsqtknryktilPnensrvllesessededssyinanyikGydeeskayvatqGPlp.......ntvadfWrmiyqe
QAPVVIMLI---EPQPHRCTRYWPVPDGN---LRSGPFEVRHHGFDKHRGFLVSSLSLTLRGKTHRFQHICLSGWNEHGLPRSSKSVIALLRYLRNLK--
...|..|| | . ..|..|.| . | | .|.. .. .. .. | .|.| .... .|. . | .| |.. .... |.. .. .
evqvivmltklkeaneqkCavyfPdaedyeiserygdveikvekiverndysvrklvlkylerersvkhywytdWPdhksPddantlldlvleveesree
--V-RGPIVVHDDRGLGPSGVFVASDYCIDQA-QAGKVDVMQAVYTLRQDRAALVESRAEYQYIHRLVLGYL
..|.||| |.| |.|.| . .. | . ..|||.. | ||.|| .|... |..||| . ||
enaklapvvvhCsaGiGrtGcfiaisiavrqlreeivvdvlkivcnlrldrGGmvqtseqyelihralclyl
|
|||||||||
| 0045098 | (Phosphotyrosine protein) phosphatases II | 267-496 | 4e-39 | 130.1 | In-house | 40-274 (278) | alignment | ||
Range on Protein: 267-496
Range on HMM: 40-274/278.0
PRILPSVTTRIQldrppgakisGFINANAVRGFqgnPMRFIVTQAPLSgfesgrvGTQVAFWSMVYQYQAPVVIMLIEPQPH---RCTRYWPvPDGNLRS
. ||| .|. ..|||. ..|. |..||.||.|| | .|| |..... .|..|| | .. | .||| ..| |.
kdilpydhsrVk..........dYINAsyidgy...pkkfIatqgPlp.......stvadfwrmlwelgitvivmltelvelgrekcaqywp.eggslty
GPFEVRHHGFDKHRGFLVSSLSLT------LRGKTHRFQHICLSGWNEHGLPRSS--KSVIALLRYLRNLK---------------VRGPIVVHDDRGLG
|.|.|. .. . . . | .| .... ..|... .| .|| | .. ||.. ||...|. ||..|| |.|
gdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsggpvlVHCsaGvg
PSGVFVASDYCIDQAqAGKVDVMQAVYTLRQDRAA-LVESRAEYQYIHRLVLGYLDG
.|..|| ...... |.||. .|| .||. | |.. |.......| .|
RtGtlvaaylmlell.eggvdlleavkelrsqRpglavqnleqyrflyefllelllr
|
|||||||||
| subfamily_PTPRD_pd | Subfamily PTPRD | 265-498 | 1.5e-38 | 127.8 | In-house | 53-285 (564) | alignment | ||
Range on Protein: 265-498
Range on HMM: 53-285/564.0
REPRILPSVTTRIQLDRPPGAKISGFINANAVRGFQgNPMRFIVTQAPLSGfesgrvgTQVAFWSMVYQYQAPVVIML---IEPQPHRCTRYWPVPDgNL
| |.. ..|. | . .| . | .|||. . |.. .. .| ||.||. | || ||.... ...|| | . ..| .||| . .
RyanivaYdhsRVvLskvegdegsDYINAsfidgyr.krkayIAtqgPlae.......tiedFWRmvweqnsstiVmltkleEkgkvkchkYWPekg.te
RSGPFEVRHHGFDKHRGFLVSSLSLTL--RGKTHRFQHICLSGWNEHGLPRSSKSVIALLRYLRNLKV--RGPIVVHDDRGLGPSGVFVASDYCIDQAQA
. | ..| . . . . ...|. . ... .. | .|| | | .|...|.| |.|. .|||||| | | .|.|.. |........
tygeltVtleeeeeladyeirtfklkkkkssesreVrqFhFtsWPdhgvpesatslLdlirkvralnepdagPivVhCSaGVGRTGtfividamlerike
-GKVDVMQAVYTLRQDRAALVESRAEYQYIHRLVLGYLDGKD
..||..| | .||..| |.|... |..||. .| .|. .
ektvDiyqyvkalrkqRnamVqteeQYiFiheailealacgn
|
|||||||||
| subfamily_Anemone-PTP-2_pd | Subfamily Anemone-PTP-2 | 225-497 | 1.9e-38 | 127.4 | In-house | 15-293 (298) | alignment | ||
Range on Protein: 225-497
Range on HMM: 15-293/298.0
AQLASVVHNMTITSLQDDFRTLPLHLA----SSKSLGEHL--LRELREPRILPSVTTRIQLDRPPGAKISGFINANAVRGFQGNPmRFIVTQAPLSgfes
.||.| .....| ....|..| .|. ... . | . |... .|. | . . ..| .||| . ...|.. ||.|||||
qklaavkkkkkltgyalefqrlnsvsseieeeekevarkpenkkkNRyadiialdssRvvLekedadeesdYiNAsflhaykgrn.afiatqaPlt....
grvGTQVAFWSMVYQYQAPVVIMLIEPQP---HRCTRYWPVpDGNLRSGPFEVRHHGFDKHRGFLVSSLSLTLRG--KTHRFQHICLSGWNEHGLPRSSK
| . || || .... ...|| . . ....||| .|. . | ..|. . ... . | | .. . |... ... . | ..| |. ..
...etvedFWrmvteedigtiVmltnleeldktkyhkywPd.egketygeitvsllskeefadlivrklkvskkkeekerevrqlhftsWpdkgvpenat
SVIALLRYLRNLKV-RG--PIVVHDDRGLGPSGVFVASDYCIDQAQAGK-VDVMQAVYTLRQDRAALVESRAEYQYIHRLVLGYLDGK
||..||| | . | |..|. | | || |.| | ...... . |||.|.| .||..|...|.....| .|. .|| .||
svldllrkvrasqqqagnkpvivqCsaGvgRsGtfiaidsvlervkkeqvvDvfqvvkvlRkkrpgavqteeqYvfiyeavlealdsf
|
|||||||||
| subfamily_PTPRB_pd | Subfamily PTPRB | 265-499 | 2.4e-38 | 126.9 | In-house | 56-290 (293) | alignment | ||
Range on Protein: 265-499
Range on HMM: 56-290/293.0
REPRILPSVTTRIQLDRPPGAKISGFINANAVRGFQGnPMRFIVTQAPLSgfesgrvGTQVAFWSMVYQYQAPVVIML---IEPQPHRCTRYWPVPDGNL
| .||| ..|..| . . | .|||| ..|.. | ||.|| || .| || ||.. .. ...|| .| .| .||| . .
rytnilpydhsrvkLaalkdesgsDYinanyipgyns.prefiatqGPlp.......etvddfWrmvwekkssiivmltqlvekgkvkCeeYWPadeepv
RSGPFEVRHHGFDKHRGFLVSSLSLTLRGKTHRFQHICLSGWNEHGLPRSSKSVIALLRYLRNLK----VRGPIVVHDDRGLGPSGVFVASDYCIDQAQA
| .| .. . . . .|... . .... .. | .|| | ..|......| .|. . ..||||| |.| .|.|.| | ... .
lyGdikvtlvaeeeledwvirelkiekekeerkvrqyhftsWpdhgvPektktlldfvrtvreaiektaskrPivvhCsaGvGRtGtfialdrllqaiee
-GKVDVMQAVYTLRQDRAALVESRAEYQYIHRLVLGYLDGKDQ
||.. |. ||..|. || . ..| .||. || .| |..
edyvdifgivaelReeRnllvqtekqYifihqcvldllrkkee
|
|||||||||
| 0042113 | (Phosphotyrosine protein) phosphatases II | 266-494 | 1.2e-37 | 125.0 | In-house | 15-243 (245) | alignment | ||
Range on Protein: 266-494
Range on HMM: 15-243/245.0
EPRILPSVTTRIQLDRPPGAKISGFINANAVRGFQGNPMrFIVTQAPLSGfesgrvgTQVAFWSMVYQYQAPVVIMLIEPQP---HRCTRYWPVpDGNLR
. ||| ||..| ..| |..|||. | |.. .| ||.||.||.. | .|| |..... ...|| |. . . | .||| .. |.
ysdilpydhtrvklspdggdldsdyinasyvdgyritpk.fiatqgPlpe.......tvedfwrmlwelgittivmLteeeelgrvkcaqywpl.geslt
SGPFEVRHHGFDKHRGFLVSSLSLT--LRGKTHRFQHICLSGWNEHGLPRSSKSVIALLRYLRN---LKVRGPIVVHDDRGLGPSGVFVASDYCIDQAQ-
| | |. ..... .. | |..| .... .|.. .| .|| | ...... .|...|. . ||..|| |.| .|.|.| .....|..
ygdftvtllseehlddytvrtlevtnlgddesrevihyhylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylmleqlek
AGKVDVMQAVYTLRQDRAALVESRAEYQYIHRLVLGYL
..|.. .||. ||. | |.. |.......| .|
elgvsleeavkelrsqRpgavqtpsqyrflyeallell
|
|||||||||
| subfamily_Urchin-PTPRB-like_pd | Subfamily Urchin-PTPRB-like | 239-494 | 1.4e-36 | 121.1 | In-house | 23-279 (288) | alignment | ||
Range on Protein: 239-494
Range on HMM: 23-279/288.0
LQDDFRTL-PLHLASSKSLGEHLLR--ELREPRILPSVTTRIQLDRPPGAKISGFINANAVRGFQGNpMRFIVTQAPLSgfesgrvGTQVAFWSMVYQYQ
.......| .|. .|.. |.. | . ||| .|..|. . . . .|||. . | ... ..| ||.|| | || .||...
fseeynsLaalektksvtagrlavnakknRyrnilpyDekrvklkkleeeagaDYinasyidgekkk.kkyiatqgPla.......dtvndfWelvyenk
APVVIML---IEPQPHRCTRYWPVPDGNLRSGPFEVRHHGFDKHRGFLVSSLSLTLRGKTHRFQHICLSGWNEHGLPRSSKSVIALLRYLRNLKV--RGP
. ..|| .| . ..| .||| | . . | ..| . . |.. .| | ... . .. .| .|| |.|.. ...||| . . . ||
tstivmltelveggktkCeeYWPdadkpknyGsvtvtlveskeledfvlrklllekkkteleitqyqylaWpdhgvPeskapllellrqvkvanqadtgp
IVVHDDRGLGPSGVFVASDYCIDQAQA-GKVDVMQAVYTLRQDRAALVESRAEYQYIHRLVLGYL
|.|| |.| .|.|.| | ||. .. ..||. .| ||. || ||. |..|.. .|
iivhCsaGvGrtgtFialdalidaveeedyiDvagtvaklRkqRallvqtlkqYefiyevllsli
|
|||||||||
| subfamily_PTPN12_pd | Subfamily PTPN12 | 265-494 | 8.6e-36 | 118.3 | In-house | 45-277 (290) | alignment | ||
Range on Protein: 265-494
Range on HMM: 45-277/290.0
REPRILPSVTTRIQLDRPPGAKISGFINANAVRGFQGNpMRFIVTQAPLSgfesgrvGTQVAFWSMVYQYQAPVVIML---IEPQPHRCTRYWPVP-DGN
| ||| ..|..| . . . |..|||| ..| .|. ...| .|.||. | || |..... .|.|. .| . ..| |||| . .
rykDilPydksrvelskieeeegsdYinanfikgvegk.leyiaaqgPLp.......ktlddfWrmiweknveivvmaCrevelgkkkCerYWpeegeee
LRSGPFEVRHHGFDKHR-GFLVSSLSLTLRGKTHRFQHICLSGWNEHGLPRSSKSVIALLRYLRNLKVR--GPIVVHDDRGLGPSGVFVASDYCIDQAQA
|. |.||| . .. .||. .| .. ........ . | .|| |.| ||...|.. .|.|. . |.||| | | |. .| || .. .|
lefgefevtleeekavdddflirtLkveaqkesrkvyqfhYtaWPDhgvPssaksllelielvrelqesedaPlvvhCsaGvGrtGtiiaidyvrellka
GKV----DVMQAVYTLRQDRAALVESRAEYQYIHRLVLGYL
.|. || . | .||..||||| .. |..... |. ..
ekipeeldvfdlvlelrkqraalvqtkeqyelvykavaelv
|
|||||||||
| subfamily_Nvec-PTP-2_pd | Subfamily Nvec-PTP-2 | 268-496 | 2.4e-35 | 116.9 | In-house | 17-244 (250) | alignment | ||
Range on Protein: 268-496
Range on HMM: 17-244/250.0
RILPSVTTRIQLDRPPGAKISGFINANAVRGFQGNpMRFIVTQAPLsgfesgrVGTQVAFWSMVYQYQAPVVIMLI--EPQPHRCTRYWPVpDGNLRSGP
|.. .|. | . | |.| .||| . |.... ||.||.|| . | . || ||..... ...|| . . . ...|||| .. . |
diialdssrvvLekekgdkesdyinasflhgyder.kafiatqgPl.......qatiedfWrmvleeksgtivmLtnLkesektyhqywPv.ekaekyGd
FEVRHHGFDKHRGFLVSSLSLTLRGKTHR--FQHICLSGWNEHGLPRSSKSVIALLRYLRNLKVR---GPIVVHDDRGLGPSGVFVASDYCIDQAQAG-K
| . ... . . | |. . |... ... | . | |. ..|..||. .. . . .|..|. | | || |.| | ..... .
vtvsllskeefadytkrklklskakkaderivrqlhfvvWPdkgvPevatavLellkkvqasqqqagnaPvivqCsaGvgrsGafiaidavlerlkkekv
VDVMQAVYTLRQDRAALVESRAEYQYIHRLVLGYLDG
|||.. . .||.|| |||.. | ......| .||
vdvfkvikvlrkdrphavesleqyvfvyeiilkalds
|
|||||||||
| subfamily_Sponge-PTP8_pd | Subfamily Sponge-PTP8 | 264-497 | 5.3e-35 | 116.0 | In-house | 50-286 (305) | alignment | ||
Range on Protein: 264-497
Range on HMM: 50-286/305.0
LREPRILPSVTTRIQLDRPPGAKISGFINANAVRGFQGNpMRFIVTQAPLSGfesgrvgTQVAFWSMVYQYQAPVVIMLI---EPQPHRCTRYWPVPDGN
| | . . ||.| . . | .|||. | |.... ..||.|.|| | . || ...... ...|| | . ..| .||| ..
nrlkeitlldddriiltekeslddsdyinasyvdgykrk.kkyivaqgPlkn.......tvadfWrliveekvstivmltklveggkdkCrqYWpeskte
-LRSGPFEVRHHGFDKHRGFLVSSLSLTL---RGKTHRFQHICLSGWNEHGLPRSSKSVIALLRYLRNLKVRG---PIVVHDDRGLGPSGVFVASDYCID
. |.|.| . . . ... |... ... . | | .|| |... |.. |.. ... . .. |..|| |.| .|||.| | ..
kkefgefsvelksektasdyieRklkisiededkesrtvlqyqltdWPdhGvpqfatsllslikrvqkdqkkdkgvpllVhCsagvgRtGvfiavdiale
QAQ-AGKVDVMQAVYTLRQDRAALVESRAEYQYIHRLVLGYLDGK
... . |||.. . .||. | .|.. ..|...| . ..
rlkkEevvdvfevlkqlRskrmkmvqtldqYvflhdaldelitcg
|
|||||||||
| 0037934 | (Phosphotyrosine protein) phosphatases II | 264-491 | 6.8e-35 | 116.2 | In-house | 14-239 (243) | alignment | ||
Range on Protein: 264-491
Range on HMM: 14-239/243.0
LREPRILPSVTTRIQLdrpPGakiSGFINANAVRGFQgnpmRFIVTQAPLSGFESGrvgTQVAFWSMVYQYQAPVVIMLIEPQ---PHRCTRYWPvpdGN
| . ||| .|. | .| |..|||| .... |.|.||.||.. . .|| |..... |..|| |.. | .||| |.
nrysdilpydhsrvkl...eg...sdyinanliyvtp....rliatqgPlpetved...dlasfwrmlwelgitvivmltelvElgrekcaqywp...ge
LRSGPFEVRHHGFDKHRGFLVSSLSLTL---RGKTHRFQHICLSGWNEHGLPRSSKSVIALLRYLR----------NLKVRGPIVVHDDRGLGPSGVFVA
. |.|.|. .. . .. | |.|. . |. .|.. .| .|| | | ......|...| .|. ||..|| |.| .|...|
vtygdftvtllseehlddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRtGtlia
SDYCIDQAqagKVDVMQAVYTLRQDRAA-LVESRAEYQYIHRLVL
...... .||. .|| .||. | |... |.......|
aylmllll...gvdleeavkllreqRpgkavqtpsqyrflyeall
|
|||||||||
| subfamily_Choan-PTP-1_pd | Subfamily Choan-PTP-1 | 274-496 | 2e-34 | 114.0 | In-house | 55-278 (281) | alignment | ||
Range on Protein: 274-496
Range on HMM: 55-278/281.0
TTRIQLDRPPGAKISGFINANAVRGFQGnPMRFIVTQAPLSgfesgrvGTQVAFWSMVYQYQAPVVIML---IEPQPHRCTRYWPVPDGNLRSGPFEVRH
||... . .| . .|||| | |..| . ..|.||.|. . |||| ||..... ...|. || .| |||| .. .|. | . |..
atrvkvtpneenkntDYinanfvpgykg.ekeyiatqgPvP.......aslvafWqmvweqkvsaivmvtreieagklkChrYWPddnselkygdvtvks
HGFDKHRGFLVSSLSL-TLRGKTHRFQHICLSGWNEHGLPRSSKSVIALLRYLRN---LKVRGPIVVHDDRGLGPSGVFVASDYCIDQA--QAGKVDVMQ
. ... .. ..| . |.| . ... | .|| | ..| .. . ... | |.|.| | | .|...| | .... .. ..|| .
taeeekatyierkfkleresgetreveqlaytaWPdhGvPattkellefrkevlkltekktkaplvihCsaGvGrtGtyialDrlvkaveaeleeldvka
AVYTLRQDRAALVESRAEYQYIHRLVLGYLDG
| ||..| .| . . |..... || .||
vvaelrkernlmvqtvvqyefvykavldaldk
|
|||||||||
| subfamily_Ptp69D_pd | Subfamily Ptp69D | 239-495 | 1.5e-32 | 108.0 | In-house | 24-287 (307) | alignment | ||
Range on Protein: 239-495
Range on HMM: 24-287/307.0
LQDDFRTLP---LHLASSKSLGEHLLRELREPRILPSVTTRIQLDRPPGAKISGFINANAVRGFQgNPMRFIVTQAPLsgfEsgrvGTQVAFWSMVYQYQ
|. ....|. .. .. | . . | . | . ||..| . .| . | .|||. ..|.. . .||. |.|. | .| || |. . .
lakeyekLeareidkstkvsekkenalknRyedikafDktRvkLkkingkedsdYinasfikgyk.ekkkfiaaqdPv...e....atigDfWRmiaeqe
APVVIMLIE--PQPH-RCTRYWPVPdGNLRSGPFEVRHHGFDKHRGFLVSSLSLTLRG-------KTHRFQHICLSGWNEHGLPRSSKSVIALLRYLRNL
...|| . ... .| .|||. . . | |. ..|| . .|... . .... ||.. |....... |.. .|.|
vtlivmlsnlteknrkkcakYWpie.devqygdilvklvseekhsdyiiReldvskkkeesgevedsrkvvqyhytgWkDskvPevargllklieqvrel
K--VRGPIVVHDDRGLGPSGVFVASDYCIDQAQAG-KVDVMQAVYTLRQDRAALVESRAEYQYIHRLVLGYLD
. |.||||| | | ||.||| | ..| .| |||... | ||..| ||.| . |....| .| | .
yklnrsPivvhCsaGvgrsgifvaldsllqqlkaedkvdifetvkdLrsqRnllvqsleqYvflyralldyss
|
|||||||||
| subfamily_Anemone-PTP-6_pd | Subfamily Anemone-PTP-6 | 263-500 | 5.6e-32 | 106.0 | In-house | 49-286 (318) | alignment | ||
Range on Protein: 263-500
Range on HMM: 49-286/318.0
ELREPRILPSVTTRIQLDRPPGAKISGFINANAVRGFQGNpMRFIVTQAPLSgfesgrvGTQVAFWSMVYQYQAPVVIMLI---EPQPHRCTRYWPVpDG
| ||. .||..|. | . | .|||| . |.. . .| .||||. | || ||.. .. |..|| | ... |||| .|
knryanilaydhtrvkLqmlegeegsDyinanyidGyrrk.kayiaaqaPlp.......etieDfWrmvWeqnsavivmltqeeergkakvhryWPs.kg
NLRSGPFEVRHHGFDKHRGFLVSSLSLTLRGKTH--RFQHICLSGWNEHGLPRSSKSVIALLRYLRNLK---VRGPIVVHDDRGLGPSGVFVASDYCIDQ
| | . . ... ....| ... . . | ..|.| |. |...|.| .. . .|||||| | | |||.| | ...
srsygklvvelkeevelsdyvlrefkvtrteeeesrqvrqyhytsWpdegvpesgaslldlvrqvskaqqksgagpivvhCsaGvGrtGvfiavdiller
AQA-GKVDVMQAVYTLRQDRAALVESRAEYQYIHRLVLGYLDGKDQK
..| . |||.| | .||. | ..| . |..|. .| .| |..
ikaealvDvfqtvkqlreqrnlmvqtedqyefiydvllealasgdte
|
|||||||||
| subfamily_Urchin-PTPRA_pd | Subfamily Urchin-PTPRA | 268-494 | 1.2e-31 | 105.2 | In-house | 69-292 (319) | alignment | ||
Range on Protein: 268-494
Range on HMM: 69-292/319.0
RILPSVTTRIQLDRPPGAKISGFINANAVRGFQGnPMRFIVTQAPLSgfesgrvGTQVAFWSMVYQYQAPVVIMLIepqPHRCTRYWPVpDGNLRSGPFE
.||. ....|.| | | .||| | |.| . ..| .| || | || |...|.. ...| ..|..||| ... . . |.
nilafdknvvklerliGeefsdyinasfvtGyqr.kdkyiaaqGPld.......ntladfWrmiweyncstivllt...kdkcsqywpl.kivikeerfk
VRHHGFDKHRGFLVSSLSLTLRGKTHRFQHI---CLSGWNEHGLPRSSKSVIALLRYLRNL----KVRGPIVVHDDRGLGPSGVFVASDYCIDQAQA-GK
|. . .. . | .. |. || . ..| . || ..| | .. .. |.. .| | . | .|||| | | .||... | .|. . .
vkvdsveetaeyvvrdielsedgkekdirkitqfhflGwpdvGvpdypsdlmrlvkkvrhltskenhranivvhcsaGvGrtGvyivldvlldrmkeekq
VDVMQAVYTLRQDRAALVESRAEYQYIHRLVLG-YL
||| . | |||.| ||.. ..|..|. .| .|
vdvynfvrdlrqqrntlvqdlvqykfiysalleehl
|
|||||||||
| subfamily_Urchin-PTP-8_pd | Subfamily Urchin-PTP-8 | 268-494 | 1.8e-31 | 104.7 | In-house | 33-256 (284) | alignment | ||
Range on Protein: 268-494
Range on HMM: 33-256/284.0
RILPSVTTRIQLDRPPGAKISGFINANAVRGFQGnPMRFIVTQAPLSgfesgrvGTQVAFWSMVYQYQAPVVIMLIepqPHRCTRYWPVpDGNLRSGPFE
.||. ....|.| | | .||| . |.| . ..| || || | || |...|.. ...| ..|..||| ... . . |.
hilafdknvvklerliGeefsdyinasfitGyqr.kdkyiatqGPld.......ntladfWrmiweyncstivllt...kdkcsqywpl.kivikeerfk
VRHHGFDKHRGFLVSSLSLTLRGKTHRFQHI---CLSGWNEHGLPRSSKSVIALLRYLRNL----KVRGPIVVHDDRGLGPSGVFVASDYCIDQAQA-GK
|. . .. . | .. |. || . ..| . || ..| | .. ...|.. .| | . | .|||| | | .||... | .|. . .
vkvdsveeseeyvvrdielsedgkekdirkirqfhflgwpdvgvpdypsdlmrlvkkvrhltskenhranivvhcsagvgrtgvyivldvlldrmkeekq
VDVMQAVYTLRQDRAALVESRAEYQYIHRLVLG-YL
|||.. | |||.| ||.. ..|..|. .| .|
vdvynfvrdlrqqrntlvqdlvqykfiysalleehl
|
|||||||||
| subfamily_Anemone-PTP-5_pd | Subfamily Anemone-PTP-5 | 265-497 | 2.2e-31 | 104.1 | In-house | 53-286 (319) | alignment | ||
Range on Protein: 265-497
Range on HMM: 53-286/319.0
REPRILPSVTTRIQLDRPPGAKISGFINANAVRGFQGNpMRFIVTQAPLSGfesgrvgTQVAFWSMVYQYQAPVVIMLI---EPQPHRCTRYWPVPDgNL
| . ||. ||..| .| . | .|||. . |.| . .|| |||||. | || ||..... .|.|| |. .. .||| .
ryqnilaydrtrvvlseldgvegsdyinasfidgyqer.ekfiatqaPlen.......tiedfWrmvWeeessivvmltklveklkvklkkywpeen.fe
RSGPFEVRHHGFDKHRGFLVSSLSLTLRGKT---HRFQHICLSGWNEHGLPRSSKSVIALLRYLRNLKVR---GPIVVHDDRGLGPSGVFVASDYCIDQA
. | . | .. .. .. |.| . . .| | .|. |....|...||. .|. . . |||||| | | | |.. | ...
eyGrlivtleeeeeledyiirklklnkkssevetRevkhfqyteWpdhdvPekatslldllkrirksrektqsgPivvhCsaGvGRtGtfivldamlerv
Q-AGKVDVMQAVYTLRQDRAALVESRAEYQYIHRLVLGYLDGK
. | .|| . | .|| | .|. . |..|. .| ...
keegvlDvfstvsrlRtqRnimvqrpeqYkfiyealleaveag
|
|||||||||
| subfamily_PTPRK_pd | Subfamily PTPRK | 265-492 | 5.5e-31 | 102.6 | In-house | 48-275 (314) | alignment | ||
Range on Protein: 265-492
Range on HMM: 48-275/314.0
REPRILPSVTTRIQLDRPPGAKISGFINANAVRGFQgNPMRFIVTQAPLSGfesgrvgTQVAFWSMVYQYQAPVVIMLIEPQP---HRCTRYWPvPDGNL
| ||. .|..| | | .|||. . ... .| ||||| || | || .||.... ..|| | . .|..||| |..
rsgdilaydrsrvflitidgdpssdyinaalidsyk.rpaafivtqgPlqe.......tvkdfWrlvydencasivmltelvevgrvkClkyWP.edtev
rSGPFEVRHHGFDKHRGFLVSSLSLTL--RG--KTHRFQHICLSGWNEHGLPRSSKSVIALLRYLRNLK--VRGPIVVHDDRGLGPSGVFVASDYCIDQA
|...| . . ..| .... || ... ... || .|. | | .....|.| . . . |.|||| | | .|.|.| | .| .
.ygdikvelvetellaelvvrifrveklargqeeirevrqfqflgWpdhdvPvsatgllklvrrvkksqeeeaGrivvhCsaGaGrtGtfiaidivldmi
QA-GKVDVMQAVYTLRQDRAALVESRAEYQYIHRLVLG
. | ||| .|| |||. . .|| |..|. .|
eregvvdvfnavktlrsrkvnmveteeqykfiydvile
|
|||||||||
| subfamily_Urchin-PTP-5_pd | Subfamily Urchin-PTP-5 | 220-500 | 1.1e-30 | 101.8 | In-house | 8-290 (297) | alignment | ||
Range on Protein: 220-500
Range on HMM: 8-290/297.0
RPLSTAQLASVV-HNMTITSLQDDFRTLPLHLASSKSLGEHL--LRELREPRILPSVTTRIQLDRPPGAKISGFINANAVRGFQGnpmRFIVTQAPLSgf
||. ...|..| .|. . ...|. || .. |. . | |||. . |..| | ..|| |.|.. |.| || |
rpiplsdfatlvqknrhtdvfseeflclpeaniqpqtvaekkvnfeksRYkniLPydssRvkLaivnddpdsDyvnasfvkgnkh...rlittqmPmk..
esgrvGTQVAFWSMVYQYQAPVVIMLIEPQ--PHRCTRYWPvPDGNLRSGPFEVRHHGFDKHRGFLVSSLSLTLRG-K-THRFQHICLSGWNEHGLPR--
| || ||...|. ...|| . . ..|.|||. .| | | . .. .||. .|..| | .. . | .. .|
.....atvadfWamvldeqvstivmlnddnerdkkcaryWs.dkgvttfGdvsvvllsvsereGfikrelevtkgkakarrvvkqyqfveWPdkaverkd
SSKSVIALLRYLRN---LKVRGPIVVHDDRGLGPSGVFVASDYCIDQAQA-GKVDVMQAVYTLRQDRAALVESRAEYQYIHRLVLGYLDGKDQK
| .|.. |. .|. . ||..|| |.| ||... | .. .|. .||... | |||.| || . .|.... .|| .| .|..
sassllklisevrkdfsqnaegPllvhclaGvGrtgvlltidsvvaeakrekevdifglvkklrqerpylvqtkeqykfvyvavleallsedtr
|
|||||||||
| subfamily_Sponge-PTP11_pd | Subfamily Sponge-PTP11 | 265-496 | 1.6e-30 | 101.0 | In-house | 51-285 (290) | alignment | ||
Range on Protein: 265-496
Range on HMM: 51-285/290.0
REPRILPSVTTRIQLDRPPGAKI--SGFINANAVRGFQgNPMRFIVTQAPLSgfesgrvGTQVAFWSMVYQYQAPVVIMLIE---PQPHRCTRYWPVPDG
| .|... || | . .| | .||| . |.. . ..|.||.|.| | | ||....| . ....||.. . ..| ||| |
RfanivvyddnritLrpisghkDCtneyinAcyikgyk.ekkqyiatqgpvs.......ntlvdFWkliwqekvtiivmltniieegkvkCqqYWpdsdt
NLrSGPFEVRHHGFDKHRGFLVSSLSLTLRGK---THRFQHICLSGWNEHG-LPRSSKSVIALLRYLRN--LKVRGPIVVHDDRGLGPSGVFVASDYCID
. |.|... . .. .. |... . . .. .. .. |...| .. . ..... . .. . ...|||| ..| |.||.| . |.
ka.ygefsikllneetlneyierklevknknsagakqsvtqyqitnwdstgkvtnpqtillvieemyktqrkrgntsivvHCSdtvgrsavfcaaattin
QAQ-AGKVDVMQAVYTLRQDRAALVESRAEYQYIHRLVLGYLDG
... | .||.| ....|. . .|.. .||.|...|| |||
kcktegvidvfqvlksqRiqkpgsvqtvqqyqgifqivltylds
|
|||||||||
| subfamily_CG7180_pd | Subfamily CG7180 | 264-493 | 4.3e-30 | 99.4 | In-house | 46-289 (296) | alignment | ||
Range on Protein: 264-493
Range on HMM: 46-289/296.0
LREPRILPSVTTRIQLDRPPGAKISGFINANAVRGFQgNPMRFIVTQAPLSGfesgrvgTQVAFWSMVYQYQAPVVIMLIEP--QPHRCTRYWPVPDgNL
|.. ..| .|. |.. | . | .||| | .| . .|||.|| | .||..||. .. |..| .. . . . ||| .
nrdvkvvPyDynRvvLekldGeeksdYinavyvdsfl.kkkeyivteapkke.......tvdefWrlvydeeisavvvLtktfdfakmypsywpnks.ke
RSGPFEVRHHGFDKHRGFLVSSLSLTLR------------GKTHRFQHICLSGWNE-HGLPRSSKSVIALLRYLRNLK-------VRGPIVVHDDRGLGP
. |...| .. . . || . .| ... | |. . .| |....| |.| | .. ..||.||. | .
qygeifveiveekqyanlkirtfkltkkivalteqekqvkaetRivklfqlteWeledkvPlstnalielrrrvrlwrekvdedpeegPvvvvssdGasR
SGVFVASDYCIDQA-QAGKVDVMQAVYTLRQDRAALVESRAEYQYIHRLVLGY
|||..| | ..... . ..||| .|| |||..| |||. ||.|| ..| .
sGvylaidanlelvekeeevdvFeavktlrrsRpqLvenveeYkyiYdvllea
|
|||||||||
| subfamily_PTPN13_pd | Subfamily PTPN13 | 268-493 | 1.3e-29 | 98.4 | In-house | 45-268 (273) | alignment | ||
Range on Protein: 268-493
Range on HMM: 45-268/273.0
RILPSVTTRIQLDRPPGakisgFINANAVRGFQG-NPMRFIVTQAPLSgfesgrvGTQVAFWSMVYQYQAPVVIMLI---EPQPHRCTRYWPVPDGN-L-
.|| ||..|. | .|||. .. | . ..|..| || | || ||.. .| |..|. | . .| ||||. .. |
nvlPydetrvklgdegg.....yinaslikvpvgkdeyeyiacqGPlP.......etvkdfwqmvweqkaeviamvtlekekgkvkchrywPesknkklk
RSGPFEVRHHGFDKHRGFLVSSLSLT--LRGKTHRFQHICLSGWNEHGLPRSSKSVIALLRYLRNLKV-RGPIVVHDDRGLGPSGVFVASDYCIDQ-AQA
|. .||. . |. || |..| .. |.... .|. . | .|| |.|..... .....|.|. .|||||| |.| ||.... | .. ..
vsnrlevellkvqkldgfvvralavkdsesgesrevahlnfvkwPdhgvPssaaellqfvaevrrlqtdagPivvhcsaGiGrsGtlitidvvlglierd
GKVDVMQAVYTLRQDRAALVESRAEYQYIHRLVLGY
..|| . | .||. | ..| .. | .... .|
kefdvkeivrklreqrqgvvqtkdqyifvykailev
|
|||||||||
| subfamily_PTPRG_pd | Subfamily PTPRG | 263-500 | 2.5e-29 | 96.9 | In-house | 50-293 (563) | alignment | ||
Range on Protein: 263-500
Range on HMM: 50-293/563.0
ELREPRILPSVTTRIQLDRPPGAKIS-GFINANAVRGFQgNPMRFIVTQAPLSgfesgrvGTQVAFWSMVYQYQAPVVIMLIE---PQPHRCTRYWPVpD
|. |... .|..| || | . .|||| . |.| ||.|| || | || |... .. ...|. . . . | .||| |
KnRylnivaydrsRvklsplpgkkkklDYinAnyidGyq.kskafiatqgplk.......dtfddFWrmiWeqnvaiivmitnlvergrrkcdvYWPk.d
GNLRSGPFEVRHHGFDKHRGFLVSSLSLTL-----RGK---THRFQHICLSGWNEHGLPRSSKSVIALLRYLRNLKVR--GPIVVHDDRGLGPSGVFVAS
. .. | ..|. ... | .|.. . .. .. . | .|| | .| |. . . . ||||||.. | | .|....
esetygalqvtlieeevlalytvrtlviknlklkkkkqcdteklvrqyhytkWPdhgvPehslpvLifvkkssaankaeaGPivvHcsaGvgrtGtyivl
DYCIDQAQ-AGKVDVMQAVYTLRQDRAALVESRAEYQYIHRLVLGYLDGKDQK
| . | | .|.| . . ..| | ||... .|...| .| . .|...
dtllkqiqqenavnvfgflkhiraqRnflvqteEqYiflhdalleaiaskete
|
|||||||||
| subfamily_PTPN6_pd | Subfamily PTPN6 | 268-498 | 7.2e-29 | 95.7 | In-house | 62-301 (306) | alignment | ||
Range on Protein: 268-498
Range on HMM: 62-301/306.0
RILPSVTTRIQLDrPPGAKISGFINANAVR-GFQGNPMRFIVTQAPLsgfesgrVGTQVAFWSMVYQYQAPVVIMLI---EPQPHRCTRYWPVPDGNLRS
||| ||. | |. . | .|||| .. ..|. ..| || | | ||.||.| .. |..|. | ..|.|||| . .
nilPfDhtrvilk.epsvpgsdyinanyikkevkgsdksyiatqgcl.......ettvsdFWrmvwqensrvivmttkevErgkekCarYWPdeeekeey
GPFEVRHHGFDKHRGFLVSSLSLT---LRGKTHRFQHICLSGWNEHGLPRSSKSVIALLRYLRN--LKV----RGPIVVHDDRGLGPSGVFVASDYCIDQ
| .|.. .... . . .||.. ..... . | .|| |.. . |...|. ... .. |||||| |.| | |. | ...
GkisvtnvseksladYilRelsvskkkkkkeerevfqyhfksWPdhgvpkdpgavLdfledvnrkqeeleeaeagpivvhCsaGiGRtGtfiviDillkl
AQAG----KVDVMQAVYTLRQDRAALVESRAEYQYIHRLVLGYLDGKD
. ..|. ..| ..|. | || . |..... . |.. |
iekkgldadidiqklvksvreqrsglvqteqqykfvykaikkyietkk
|
|||||||||
| subfamily_PTPN3_pd | Subfamily PTPN3 | 265-489 | 8.2e-29 | 95.4 | In-house | 46-270 (280) | alignment | ||
Range on Protein: 265-489
Range on HMM: 46-270/280.0
REPRILPSVTTRIQLDRPPGakisGFINANAVRG-FQ--GNPMRFIVTQAPLSgfesgrvGTQVAFWSMVYQYQAPVVIML---IEPQPHRCTRYWPVPD
| ||| .||..|. . .|||| | . | |.|.|| ||. | || ||.. .. ...|| .| .| .||| ..
ryrdilpydatrvklkeset....dyinanyvnmeipstglvnryiatqGPla.......ktatdfWqmvweqksslivmlttlverGrvkChqyWPete
GNLRSGPFEVRHHGFDKHRGFLVSSLSLTLRG--KTHRFQHICLSGWNEHGLPRSSKSVIALLRYLRNLK--VRGPIVVHDDRGLGPSGVFVASDYCIDQ
.|. | |.|. . |... ... | |. . . .. .. | .||.| .|.... ... .|.|. . |.||| |.| .||... . ..
deleygefsvkcekedetksyvlrelvlkdketkeerkilqlqylaWpdhgvPddsadflefvervrklrsgkeePvvvhCsaGigrtGvlilletalal
AQ-AGKVDVMQAVYTLRQDRAALVESRAEYQYIHRL
. | .| ... | |.|. ||.||.. . |...
ieaaepvypldivrtmrdqramlvqtasqykfvCea
|
|||||||||
| subfamily_PTPN9_pd | Subfamily PTPN9 | 273-494 | 1.3e-28 | 94.9 | In-house | 55-290 (297) | alignment | ||
Range on Protein: 273-494
Range on HMM: 55-290/297.0
VTTRIQLDRPPGAKISGFINANAVRGFQgNPMRFIVTQAPLSgfesgrvGTQVAFWSMVYQYQAPVVIML---IEPQPHRCTRYWPVPDG-NLRSGPFEV
||..| . .. . | .|||| | |.. .. || || || | || ||.. .. |..| .| . .|..||| .. . | ..|
detrvvlakvdedeasdyinanfvdGyk.qkkafiatqGplk.......ktvsdfWrmvWeqevlvivmttrvvergrlkcgqyWpleeessaefgdlsv
RHHGFDKHRGFLVSSLSLT--LRGKTHRFQHICLSGWNEHGLPRSSKSVIALLRYLRNLK--------------VR-GPIVVHDDRGLGPSGVFVASDYC
.. .... . |..| .. ... . | . .| ..| |.|..|.. .|. |. . .. ||||| |.| .| |.. |.|
snveveeeedykvrvleiknvkteesrkvthfqflsWPdyGvPssaaslldvlekvrekqalavkelgdewkghpsgPPivvhcsaGiGrtGtfitldic
IDQAQ-AGKVDVMQAVYTLRQDRAALVESRAEYQYIHRLVLGYL
... . |.|||...| .||. || . |.. . || |
lsrleevgtvdvvetvkllrtqrafsiqtpeqyefcylavleya
|
|||||||||
| subfamily_PTPRA_pd | Subfamily PTPRA | 240-496 | 7.1e-28 | 92.4 | In-house | 35-298 (330) | alignment | ||
Range on Protein: 240-496
Range on HMM: 35-298/330.0
QDDFRTLPL-HLASSKSL--GEHLLRELREPRILPSVTTRIQLDRPPGAKISGFINANAVRGFQGNpMRFIVTQAPLSgfesgrvGTQVAFWSMVYQYQA
...| .|| .. .. | | . | ..||| .|. | | . | .||| . |.. .|| .| |.. | || |......
reefnalPagpiqatlelaskeenkeknrvvnilPydfsrvilsvkeGveesdyinasfidGykek.dkfiaaqGPke.......etvedfwrmiweqks
PVVIMLIE---PQPHRCTRYWPVpDGNLRSGPFEVRHHGFDKH-----RGFLVSSLSLTLRGKTHR-FQHICLSGWNEHGLPRSSKSVIALLRYLRNLK-
..|| | . ..|..||| .| . | | . | ||| |. . | |..| . . . .| . |.| .. .. ||. ...|.
ativmltelkerkeekcaqywPd.eGlvtyGnirvevedetvlvdytvrkflvqqlpdatrekksrlvrqfhftswPdvGvPfepiGmlkllkkvkklnq
-VRGPIVVHDDRGLGPSGVFVASDYCIDQAQA-GKVDVMQAVYTLRQDRAALVESRAEYQYIHRLVLGY-LDG
|||||| | | .| |.. | ... .| .|||| ..| ||. |. .| . |..|.. .| | | |
qsagpivvhcsaGvGrtGtfivldavlervkaerkvdvfefvkrlrlqrpqmvqtdeqyefiykvlleyylyg
|
|||||||||
| subfamily_Urchin-PTP-6_pd | Subfamily Urchin-PTP-6 | 222-495 | 2e-27 | 90.5 | In-house | 2-277 (515) | alignment | ||
Range on Protein: 222-495
Range on HMM: 2-277/515.0
LSTAQLASV-VHNMTITSLQDDFRTLPLHLASSKSLG--EHLLRELREPRILPSVTTRIQLDRPPGAKISGFINANAVRGFQgNPMRFIVTQAPLSGfes
| ||. . .| | . ..|. || ... | . | ||| ..|..|. . | ..|| ...|. | .| .|.|.
lplaqfPafvnknrhttlfseefhdlpgpniypqtvaqeeinfkknryknilPydsvrvklevindnPhsdyfnasyipsfd.ndkayiasqgPnka...
grvgTQVAFWSMVYQYQAPVVIMLIEP---QPHRCTRYWPV-PDGNLRSGPFEVRHHGFDKHRGFLVSSLSLTLRGKTHRFQHICLSGWNEHGLPRSSKS
. ||..|.|.. ..|. . .|..||| | .. | ..| . | . | .. ... . .| ..| |. ..|
....svddfWrlvlqenvttiamvtklkegdkikcgkyWPdkpgdsvkfGsikvelvsleactggikrkltvlkgddsrtvtqfhfteWPdkGvpkhtss
VIALLRYLRN--LKVRGPIVVHDDRGLGPSGVFVASDYCIDQAQAG-KVDVMQAVYTLRQDRAALVESRAEYQYIHRLVLGYLD
.. |.. .. .. |...| | | ||... | .. .|. . |||.. | .||.| || . .| .|. || .|
llklikevkadhgqythpliihcsaGvGrtGvvisidsvvahakttrmvdvfnfvtnirqkrpylvqtqeqyafiygavledll
|
|||||||||
| subfamily_Urchin-PTP-1_pd | Subfamily Urchin-PTP-1 | 221-495 | 2.4e-27 | 90.6 | In-house | 2-278 (315) | alignment | ||
Range on Protein: 221-495
Range on HMM: 2-278/315.0
PLSTAQLASVVHNMTI-TSLQDDFRTLPLHLASSKSLGEHL--LRELREPRILPSVTTRIQLDRPPGAKISGFINANAVRGFQGNpMRFIVTQAPLSgfe
|. ||. ..| . . . ..|. || .. . . . . | ||| ..|..|. | .||| ..... . .| .|.||
pipvaqfpafvnknrhtalfseefhdlpdPdiyrqrvaretinfkknryknilPldsarvkleviddsPdsdyinasyiksvddd.kayiasqgPlk...
sgrvGTQVAFWSMVYQYQAPVVIMLIEPQP-H--RCTRYWPVPDGN-LRSGPFEVRHHGFDKHRGFLVSSLSLTLRGKTHRFQHICLSGWNEHGLPRSSK
. ||.||.|... ..|. . | .| .||| ... . | ..| . . . | . .... . .| ..| .. .
....asvddfwrmvlqekvttivmvtkkqegdkikcrqywPdrkadsvefGsikvellsleadtdgvarklvtrkseesrtvtqfqftewPdkGvdkqts
SVIALLRYLR--NLKVRGPIVVHDDRGLGPSGVFVASDYCIDQAQAG-KVDVMQAVYTLRQDRAALVESRAEYQYIHRLVLGYLD
|.. |.. .. | | ...|| | | .||... | ...|.. . |||.. | .||..| || .. || .|. || .|
sllklikevkadngkkefsllvhcsaGvGrtGvvisidevvaqikrtrsvdvfnfvknlrakrpylvqteeeyafiydavledll
|
|||||||||
| subfamily_Urchin-PTP-7_pd | Subfamily Urchin-PTP-7 | 269-492 | 2.7e-27 | 90.5 | In-house | 58-277 (315) | alignment | ||
Range on Protein: 269-492
Range on HMM: 58-277/315.0
ILPSVTTRIQLDRPPGAKISGFINANAVRGFQgNPMRFIVTQAPLsgfesgrVGTQVAFWSMVYQYQAPVVIML---IEPQPHRCTRYWPvpDGNLRSGP
|.. .|.|| . | ..||| . |.. . |.| .|.|. | . || .|.... ..|| .| . ... .||| | .. |.
iiaydksrvqlpllendphsdyvnanfidGyn.kkrryiaaqgpn.......vasvkdfwrlvfeedigkivmltnlvegekrkaekywp..dkkviyGk
FEVRHHGFDKHRGFLVSSLSLTLRGKTHRFQHICLSGWNEHGLPRSSKSVIALLRYLRNLK--VRGPIVVHDDRGLGPSGVFVASDYCIDQAQAGK-VDV
. | . ... . | .|| . . . . . .. | . |.|... ... | | . . |.|||| . | | .| |.. | .|||.| . .||
itvtrkseevnteytvrtlsvvfgdnirevvqlhytswpdmgvpkytiplmnlirtvkqhhtnsvgaivvhcsaGvGrtGtfitldavldqaeaenaidv
MQAVYTLRQDRAALVESRAEYQYIHRLVLG
... .|| | .|.. ..||.|. .|
ynfitgvrqnrikmvqvaeqyqfiydalle
|
|||||||||
| subfamily_Sponge-PTP10_pd | Subfamily Sponge-PTP10 | 266-497 | 3.2e-27 | 90.2 | In-house | 53-281 (287) | alignment | ||
Range on Protein: 266-497
Range on HMM: 53-281/287.0
EPRILPSVTTRIQLDrppgAKISGFINANAVRGFQGNpMRFIVTQAPLSgfesgrvGTQVAFWSMVYQYQAPVVIMLIE---PQPHRCTRYWPVPDGnLR
.||. |. | . .||| . |.. . .||....|.. | . || .. . . ....|| . . . | .||| . .
ltqilvpdnyrvllk....gehpdyinavfidgykek.kafiiaesPmf.......ntarnfWkliddrnvtaivmlcqekendeevcyqyWpeeks.vv
SGPFEVRHHGFDKHRGFLVSSLSLTLRGKTHRFQHI---CLSGWNEHG-LPRSSKSVIALLRYLRNLKV--RGPIVVHDDRGLGPSGVFVASDYCIDQAQ
|..... ... |... | .. ..|. |.. . |...| ... ... . . .. . ...|||| . | |..|.| . |....
lGeyniellneevnagyierklevknknkagdkqqvkqyqitnWdstgkvtepqtillvieemyktqrkrgntsivvhCsdtvGrsamfcaaattinkck
-AGKVDVMQAVYTLRQDRAALVESRAEYQYIHRLVLGYLDGK
| .||.| . |. . | ..|..| .|| |||
teGviDvfqvlksqriqkpgsvqtveqykfindivleyldsf
|
|||||||||
| subfamily_PTPN23_pd | Subfamily PTPN23 | 263-493 | 4.1e-26 | 86.4 | In-house | 46-279 (288) | alignment | ||
Range on Protein: 263-493
Range on HMM: 46-279/288.0
ELREPRILPSVTTRIQLDrppgAKISGFINANAVRGFQGNPMRFIVTQAPLSgfesgrvGTQVAFWSMVYQYQAPVVIMLIEPQP---HRCTRYWPVPDG
| ||| .|..|. . .||| |.. ||.||||| .| ||.|||. ...|..||.... ... |||| |
knrsrdilPyDhnRvklr....gskDDYinAsfvkdlspgcPdfiatqaPlq.......stlnDFWlmvyeqkssviVmllskeelgkpkvdrYwPedkg
NLR-SGPFEVRHHGFDKHRGFLVSSLSLTLRGKT--HRFQHICLSGWNEHGLPRSSKSVIALLRYLRN------LKVRGPIVVHDDRGLGPSGVFVASDY
. |...| . . . |.|. ... . .|. | | |.|.| | ......| .. |.. |.||| | | .|||
etvkfgdlsvtlksvretethvervlkletldadavksvshlqltsWpelGvPasPetllqfldevesayeavqrksktPlvvhCsaGvgRtgvfalvya
CIDQ--AQAGKVDVMQAVYTLRQDRAALVESRAEYQYIHRLVLGY
. . .. | .|..| | .||..| |. ..... || .
avrelekgnglldiiqvvsrlreqRrfmvqekeqlkfsyeavlea
|
|||||||||
| subfamily_Sponge-PTP5_pd | Subfamily Sponge-PTP5 | 262-502 | 3.3e-25 | 83.5 | In-house | 35-274 (283) | alignment | ||
Range on Protein: 262-502
Range on HMM: 35-274/283.0
RELREPRILPSVTTRIQLDRPPGakisGFINANAVR--GFQGNPMRFIVTQAPLSgfesgrvGTQVAFWSMVYQYQAPVVIML---IEPQPHRCTRYWPV
| |. |.| |..|. . .||| . . . ..|..|.|| |.| || ||.. .. ..|| | . .|..|||
rknrnqeivpadqwrvelksesr....dyinavfipvsksykqdkkyiiaqsPld.......rtvvdfWkmvfdekitaivmltklqedlrikCsqyWPk
pDGNLRSGPFEVRHHGFDKHRGFLVSSLSLTLR---GKTHRFQHICLSGWNEHGLPRSSKSV--IALLRYLRNLKVRGPIVVHDDRGLGPSGVFVASDYC
.| |.| | . .. | . | | .| | . .| | | |. . ... |.. . .|||||| | | ..||.|
.rGsedyGeftvtlrkettsnsfiikelllrvnssakstlllahyqvidWleygeqaiinslvkfnkvislqteskkgPivvhCstgiGrtavfiaasas
IDQAQAGK-VDVMQAVYTLRQDRAALVESRAEYQYIHRLVLGYLDGKDQKGA
...|.. |||.. | .|..| .| .. |. .| ||| | . |
vkdaltesvvdvfavvkimreqrmmavqtldqyklvhelvleqalcgdtqia
|
|||||||||
| 0036282 | (Phosphotyrosine protein) phosphatases II | 289-488 | 5.2e-25 | 83.5 | In-house | 3-164 (174) | alignment | ||
Range on Protein: 289-488
Range on HMM: 3-164/174.0
GFINANAVRGFQGNPmRFIVTQAPLSgfesgrvgtqvaFWSMVYQYQAPVVIMLIEPQPHR---CTRYWPVpdgnlrsgpfevrhhgfdkhrgflvssls
.|||. . .. .| |.|..|.||. || |..... .|.||.|... | .|||
dyinaspldlsyitp.rliagqgpla............fwemlkelgittvvmlleekelglykcinywpe.............................
lTLRGKTHRFQHICLSGWNEHGLPRSSKsVIALLRYLRNLKVR---GPIVVHDDRGLGPSGVFVASDYCIDQAQAGKVDVMQAVYTLRQDRAALVESRAE
. .. ... .| || | .|. .. ....... . ||..|| |.| .|..|| .... . . ||... |..||. | |..
.lredlerlgiqylylpwpDhgvpdlsi.llefvkfveealsedpggpvlVHCsaGvgRtGtlvaaylmlrglleslvdaldlvrelRlqrpgmvqtpsQ
YQYIHR
|....
yrflyy
|
|||||||||
| subfamily_Anemone-PTP-4_pd | Subfamily Anemone-PTP-4 | 275-491 | 1.8e-24 | 81.3 | In-house | 18-236 (237) | alignment | ||
Range on Protein: 275-491
Range on HMM: 18-236/237.0
TRIQLdRPPGAKiSGFINANAVRGFQGNPMRFIVTQAPLsgfESgrvgTQVAFWSMVYQYQAPVVIML---IEPQPHRCTRYWPVPDGNLRSGPFEVRHH
.|. | . .|.. | .|||. ..||.| | ..| .| || || . || ||.| . |..|| || . .| .||| | | . | .
srvvl.kgagsg.sdyinatylkgfdgtpkkyiaaqgpl...es....scddfwqmvwqekcsvivmltgliegnelkchkywpstdqpaaygvltvslk
GFDKHRGFLVSSLSLTLRGKTHRFQHI---CLSGWNEHGLPRSSKSVIALLRYLRNLK----VRGPIVVHDDRGLGPSGVFVASDYCIDQAQAGK-VDVM
.. . | || |. |.. . . | .. | ..|.|. . ... . . . | || ..| |.| .|.|. | . ||. | ||.
kkeefsdytvrslllskrltlkevrlihqyqftswpdrgvpqqtaallrfrkniinrsphvsesgpwiihcsagvgrtgiflvidamlrqakekkvvdiy
QAVYTLRQDRAALVESRAEYQYIHRLVL
. ||.. .|| ..... .| .||. .|
nyvysieedrpyiiqtkdqyvfihqtil
|
|||||||||
| subfamily_egg_pd | Subfamily egg | 254-494 | 2.8e-24 | 80.3 | In-house | 34-270 (307) | alignment | ||
Range on Protein: 254-494
Range on HMM: 34-270/307.0
KSLGEHLLRELREPRILPSVTTRIQLDRPPGAKISGFINANAVRGfqgNP--MRFIVTQAPLSgfesgrvGTQVAFWSMVYQYQAPVVIMLIE-PQPHRC
... . | |..|. ..|..|. . | . || || |.| .| ||..|||| |. || ||.| . . ..|| ...||
taasdnnlekarskrvhckdssrvklelrrGqylddfihanrvkG...kpllnefilaqaplk.......ntvddfwrmvfqeevqyivmltsrkeserc
TRYWPV-PDGNLRS--GPFEVRHHGFDKHRGFLVSSLSLTLRGKTHRFQHICLSGWNEHGLPrSSKSVIALLRYLRNLKvrGPIVVHDDRGLGPSGVFVA
||| .. .|. | ... . |.. | | | | . ... .. . . | . .|| |||| |.||.| | ....||
eyywpkaesdslvtvpGslrienlkvdskadplfrvtklklvGgddeerflehwqgdvnnss.dvysplrvlrklrnls..kpvvvqdilGvskaatlva
SDYCIDQAQAG---KVDVMQAVYTLRQDRAALVESRAEYQYIHRLVLGYL
. . . | | |..|| ||. | ||| | ...|||| ..
ieiallsllrGpitkslvlravvflrlrrrlsvesvllylfvyrlvlfff
|
|||||||||
| subfamily_Urchin-PTP-3_pd | Subfamily Urchin-PTP-3 | 267-496 | 4.6e-24 | 80.1 | In-house | 55-291 (325) | alignment | ||
Range on Protein: 267-496
Range on HMM: 55-291/325.0
PRILPSVTTRIQLDRPPGAKISGFINANAVRGFQGNPMrFIVTQAPLSgfesgrvGTQVAFWSMVYQYQAPVVIML--IEPQPHRCTRYWPVPDG-NLRS
. ... .|. | . | .|||. .| ... . |. .||||. | .| .|......||..| .. . .||. ||| | .
knvvaldksrvvletkkddpssdyinasylrddkkkdv.flaaqaPlt.......atindlWrlvldWrcsvvvvlneldlgkdrcavywpkemgksktf
GPFEVRHHGFDKHRGFLVSSLSL--TLRGKTHRFQHICLSGWNEHGLPRSSKSVIALLRYLRN--------LKVRGPIVVHDDRGLGPSGVFVASdYCI-
|..||. .. .. | . . .|.| . | .|.. | .. ..|..|. . . | .||.|| |.| .|||.. |..
GglevklrtieeisdyvhrvldvkqvkkGetrsvkqfqlqswddmGvqkrpatlisilqlvkavservtantkastpilvhcsaGvGrtGvfisl.ysal
DQ-AQAGKVDVMQAVYTLRQDRAALVESRAEYQYIHRLVLGYL-DG
.. . .||... | ||.|| ..||. .| |. . .. |
akvieesrvdifgfvkklrkdrpsmvetvdqyiliyealveaymsg
|
|||||||||
| subfamily_PTPN14_pd | Subfamily PTPN14 | 265-495 | 1.8e-22 | 74.7 | In-house | 54-297 (300) | alignment | ||
Range on Protein: 265-495
Range on HMM: 54-297/300.0
REPRILPSVTTRIQLDrPPGAKISGFINANAVRG-FQGNPMRFIVTQAPLsgfESgrvgTQVAFWSMVYQYQAPVVIMLIEP---QPHRCTRYWPVP---
| . .|| .|..| | . .|.||| .. |. . .||.|.|| | | || ||.. . ...|| | ... .|.|
rfkdvlPyednrvels.ptkenstgyinassikvsvggkersyivaqgPl...el....tvqdfWqmvWeqgvqlivmlteeeedgkeksfkyfPklesk
DGNLRSGPFEVRHHGFDKHRGFLVSSLSLT--LRGKTHRFQHICLSGWNEHGLPRSSKSVIALLRYLRNLKV-----------RGPIVVHDDRGLGPSGV
... | |.| . .. . ..| | . .. |. | .||.|. |. . |. .. .. . |..|| | | .||
kktvefgkfkvttkfsedsdsvittglklkhlpskeertvwhlqytDWpdhgvPeDvkgflsyLeevqsvrrktnseveskeskPPvlvhCsaGvGrtGv
FVASDYCIDQAQAG-KVDVMQAVYTLRQDRAALVESRAEYQYIHRLVLGYLD
. || | . . ..|. ... .||. | ||.. | |........ ||.
lilsdlliatlehneeidikkvlarLreqrmllvqtlaqYkfvYkvlikylk
|
|||||||||
| subfamily_Choan-PTP-3_pd | Subfamily Choan-PTP-3 | 266-495 | 2.9e-22 | 73.8 | In-house | 44-278 (287) | alignment | ||
Range on Protein: 266-495
Range on HMM: 44-278/287.0
EPRILPSVTTRIQLDRPPgAKISGFINANAVRGFQGNpMRFIVTQAPLSGfesgrvgTQVAFWSMVYQYQAPVVIML---IEPQPHRCTRYWPVPDGNLR
.|| ||. | . . | .|||| | ... . .||..|.|.. | || .|.. .. .||.. .| .| .||| .. .|
yadvlPiddtrvllsaeg.elGsdyinanyvasytdd.eafiaaqgPiaa.......tvrdfwravletrsasvitmtreveearlkcykywPerevPmr
SGPFEVRHHGFDK-HRGFLVSSLSLT-LRGKT-HRFQHICLSGWNEHGLPRSSKSVI----A---LLRYLRNLKVRGPIVVHDDRGLGPSGVFVASDYCI
| . | .|. . . | .| | | .. . . . | | ...|. .. ..| . |. . ||.||||| |.| ||...| ..
vGGysvvlldydikePeygvralrlidletrearvvkqldllswPdkvlaPtavglirfvldvkqhielardasevGPlvvhddvGiGrsGillatlvlv
DQA-QAGKVDVMQAVYTLRQDRAALVESRAEYQYIHRLVLGYLD
.. . |.||| ..| ||. ||||| . .... . |
srledlGrvdvaavvirlreyraalvqavvqlrllyealvtyyk
|
|||||||||
| subfamily_Cele-PTP-6_pd | Subfamily Cele-PTP-6 | 276-494 | 3e-22 | 74.0 | In-house | 57-277 (307) | alignment | ||
Range on Protein: 276-494
Range on HMM: 57-277/307.0
RIQLDRpPGAkISGFINANAVrGFQGNPMRFIVTQAPLSgfeSgrvgTQVAFWSMVYQYQAPVVIML---IEPQPHRCTRYWPVPDGNLR-----SGPFE
|| . .|. | .| || . | .| .||..| || . || ||.|. | . |||| || .| .|||. .|. .
rivvkf.dgl.asdyihanyl.giaikpkkficaqgple...n....tqysfwamaiqekvesvimlckvielakikceqywpleegqklvfgeapntis
VRHHGFDKH----RGFLVSSLSLTLRGKTHRFQHICLSGWNEHGLPRSSKSVIALLRYLRNlkVRGPIVVHDDRGLGPSGVFVASDYCIDQAQAGK--VD
| | .| |..| . .|. ||. . | ..| |. . | || | . |.||| |.| || || . |. ||. |
vanlgakklapdedlinvttlkvdwaqksrtiqhlqwenwpdrgvpqinltainlleavry..dtnpvvvhcsaGvGrsGtivaislvqdkmiaGinckd
VMQAVYTLRQDRAALVESRAEYQYIHRLVLGYL
. . | ||..| ... |.| |.||..| |.
mkklveelrsqrhyaiqteaqylylhrvlleyf
|
|||||||||
| 0041856 | (Phosphotyrosine protein) phosphatases II | 287-494 | 5.4e-22 | 73.7 | In-house | 18-171 (182) | alignment | ||
Range on Protein: 287-494
Range on HMM: 18-171/182.0
ISGFINANAVRGFQGNPMrFIVTQAPLSGfesgrvgTQVAFWSMVYQYQAPVVIMLIepqphrCTRYWPvpdgnlrsgpfevrhhgfdkhrgflvsslsl
. .|||| ..| . . ||.||.|| . | .|. |..... ....| . .|||
dldyInanlylgslpatr.fiatqgplls.......tvadflrmlkelgittivnlt......eelywp...............................
tlRGKTHRFQHICLSGWNEHGLPRsSKSVIALLRYLRNlkVRGPIVVHDDRGLGPSGVFVASDYCIDQaqagKVDVMQAVYTLRQDRAALVESRAEYQYI
.. ... .| || | ....... .. ||..|| |.| .|..|| .... . .|.. .|| ..|. | |.. |...
..ellerlgiqylylpwpDhgvpd.ldelldfieevle..eggpvlVHCsaGvgRtgtlvaaylmkkl....gvsleeavklvrsrRpgmvitpnqyffl
HRLVLGYL
....| .|
qlallell
|
|||||||||
| 0051429 | (Phosphotyrosine protein) phosphatases II | 287-495 | 1.9e-21 | 72.4 | In-house | 3-226 (272) | alignment | ||
Range on Protein: 287-495
Range on HMM: 3-226/272.0
ISGFINANAVRGFqGN---PMRFIVTQAPLSGfesgrvgTQVAFWSMvYQYQAPVVIMLIEPQ---PHRCTRYWP-----------VPDGNLRSGPFEVR
.|| |||. | |. |. | |.. ...|| |. || . .... ....| .. . | |||| . . | . |.
lsgyiNardvggy.grvvkpgrlyrsggplpl.......taadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvt
HHGFDKHRGFLVSSLSLT---LRGKTHRFQHICLSGWNEHGLPRSSksVIALLRYLRNlkvRGPIVVHDDRGLGPSGVFVASDYCIDQAQ-AGKVD----
.. . . ... | || |..... |. .| || |... ...||..|.. ||..|| | . .|..|| .... . ||
llseellldyilrellltlllsagearevmhlhytdwpdhgvpqea..llellellld...ggpvlvHCsaGkdRTGtvvallllllgvsletivddYll
----VMQAVYTLRQDRAALVESRAEYQYIHRLVLGYLD
. .|| ||. |.. |.. . |..... .| .|.
tnlyleeaveelraqrpgavqteeqylflyeallellr
|
|||||||||
| subfamily_Cele-PTP-1_pd | Subfamily Cele-PTP-1 | 288-491 | 6.9e-21 | 69.6 | In-house | 46-256 (290) | alignment | ||
Range on Protein: 288-491
Range on HMM: 46-256/290.0
SGFINANAVRgfQGNPMRFIVTQAPLSGFESGRVGTQVAFWSMVYQYQAPVVIMLIE---PQPH----RCTRYWPVPDG-NLRSGPFEVRHHGFDKHRGF
...| || | | .|.|.||.|. . | | || |. | .. |.|| | .... |..| | | .|. . ..|. |. ..
ddyiHAnrvt..cpnglrliltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCakYvpesvgeelkfkgltvkCkskekeddv
LVSSLSLTLR-GKTHRFQHICLSGWNEHGLPRSSKSVIALLRYLRnlKVRGPIVVHDDRGLGPSGVFVASDYCIDQAQ--AGKVDVMQAVYTLRQDRAAL
. | .. .. . ..| |.|||. ....|....|..... . . |..||. |. | .. |.. |.| . .....||. || .
etRelvvkfddeeeftvtHsllkgWnklnvqedtktllsliqkvk..asktpvivHcvdGiSrsAalaaiilgyQkiaetsgsvkledvlkalrkqrala
VESRAEYQYIHRLVL
. | |. .. ..
itsalelafvdagiv
|
|||||||||
| subfamily_PTPRN_pd | Subfamily PTPRN | 258-489 | 1.4e-20 | 68.2 | In-house | 54-287 (297) | alignment | ||
Range on Protein: 258-489
Range on HMM: 54-287/297.0
EHLLRELREPRILPSVTTRIQLDRPPGAKISGFINANAVRGFQGNPMRFIVTQAPLSgfesgrvGTQVAFWSMVYQYQAPVVIMLIEPQP---HRCTRYW
|. ... |. .|| .|..|.. |. | .||| |. . .| ||.||. | .|| ||.. . |...| . . ..|.|||
eknvkknrskavlpydhsrvklkeeasaeksdyinasaildhdprapayiatqgpla.......stvadfwqmvweqGvvvivnltrleeegvkqckryw
PVpDGNLRSGPFEVRHHGFD-KHRGFLVSSLSLT-LRGK-THRFQHICLSGWNEHGLPRSSKSVIALLRYLrNLKVRG---PIVVHDDRGLGPSGVFVAS
| .|. . .||. .|| |. | |. . | |.|.| | |.||.. . | . | || ||||| | | .||...
pd.eGsevyhiyevhlvsehiwcddylvrsfylknlqtsetrtvtqfhflswpeegvPasaksllefrrkv.nksyrGrscpivvhcsdGaGrtGvyili
DYCIDQAQAG--KVDVMQAVYTLRQDRAALVESRAEYQYIHRL
| ... . | ..|.. .. ||..|. ||.........
dlvlnrllkGvkeidiaatlehlrdqrpglvktkdqfefalta
|
|||||||||
| subfamily_PTPN1_pd | Subfamily PTPN1 | 269-484 | 1.8e-20 | 67.9 | In-house | 41-261 (290) | alignment | ||
Range on Protein: 269-484
Range on HMM: 41-261/290.0
ILPSVTTRIQLDRPPGakisGFINANAVRgFQGNPMRFIVTQAPLsgfesgrVGTQVAFWSMVYQYQAPVVIML---IEPQPHRCTRYWPVPDG----NL
. | .||.|.| .|||. | .. ..|.|| || . | || ||.. .. |.|| .| . .|..||| . |
vspydhsrikleradn....dyinaslve.leeakrsyiltqGPl.......pntvdhfWqmvWeqkskavvmlnkvvekeqikcaqywPqgeeekelll
RSGPFEVRHHGFDKHRGFLVSSLSLTL--RGKTHRFQHICLSGWNEHGLPRSSKSVIALLRYLRNLK----VRGPIVVHDDRGLGPSGVFVASDYCIDQA
..|. .... . |. | |. .|. | |.. |.|.| . . .| .|. || |.| |.| || |. | |. .
edtklkvkliseerksyytvrllelenlktqetreilhfhyttwpdfgvpespaaflkflfkvresGslssdvGpavihcsaGiGrsGtfclvdtclvli
QA----GKVDVMQAVYTLRQDRAALVESRAEYQ
.. ||. . . ||. | |. .
ekkddlssvdikkvllelrkyrlGliqtadqlr
|
|||||||||
| subfamily_Cele-PTP-10_pd | Subfamily Cele-PTP-10 | 277-503 | 4.7e-20 | 66.4 | In-house | 72-299 (305) | alignment | ||
Range on Protein: 277-503
Range on HMM: 72-299/305.0
IQLDRPPgakISGFINANAVRGFQGNPMRFIVTQAPLSGfesgrvgTQVAFWSMVYQYQAPVVIML---IEPQPHRCTRYWPVPDGN---LRSGPFEVR-
..||.|. | .| || | |||..| || | || || | . ..|| .| .|..|||. |. |.||
vkldkps...psdyihanyvgcpmipekrficaqgpldq.......tidefwwmviqnkveqivmlcktvelgklkcaqywpaaqgeklelksgivvenv
--HHGFDKHRGFLVSSLSLTL-RGKTHRFQHICLSGWNEHGLPRSSKSVIALLRYLRNLKVrgPIVVHDDRGLGPSGVFVASDYCIDQAQAGK-VDVM-Q
. ... .. | || ... .|. . | . |.| . . || .| || ||||| |.| .| || .| ... | . | .
sgskpmerdaeiqitllnltysgdqkmsvrhlqwtewpdrgvppckltslellsairgskv..pivvhcsagigrtgtivaieyilekiaenkpcppmpe
AVYTLRQDRAALVESRAEYQYIHRLVLGYLDGKD-QKGAA
| .||..|| ... .| .|||..| |. | .| ||
lvkalrdqrafsiqndvqylfihrvmlnyflekykekyaa
|
|||||||||
| subfamily_Cele-PTP-20_pd | Subfamily Cele-PTP-20 | 289-493 | 1.9e-19 | 64.4 | In-house | 82-282 (290) | alignment | ||
Range on Protein: 289-493
Range on HMM: 82-282/290.0
GFINANAVRGFQgnPMrFIVTQAPLSgfesgrvGTQVAFWSMVYQYQAPVVIML---IEPQPHRCTRYWPVPDGN-LRSGPFEVRHHGF-DKHRGFLVSS
.. || |.| . .| ||.|| .| | . .| || | .. ...|| || .| .|.| .|. | | . | ||
dyvhanyvkGlk..am.filtqGalk.......dtvidiwrmvlqekvaaivmlceliedGkakceqyypekeGevltfGeitvlcseeddkdaniikkt
LS--LTLRGKTHRFQHICLSGWNEHGLPRSSKSVIALLRYLRnlKVRGPIVVHDDRGLGPSGVFVASDYCIDQAQAGK-VDVMQAVYTLRQDRAALVESR
|| || |...|. . | .. .. |. ... .|| || |. ||.||| |.| .| ||| . ... || .|... | .||. |.. |.
lsvrdkdsGkehklkhlkikswpdksvalstlallrtlrilr..kasGpvvvhcsaGiGrtGtfvaievglqilldGkeldlldlvralrnsrlnsvqvd
AEYQYIHRLVLGY
.| . ...| .
iqylalveilldl
|
|||||||||
| subfamily_Nvec-PTP-1_pd | Subfamily Nvec-PTP-1 | 276-491 | 2.8e-19 | 64.2 | In-house | 23-237 (239) | alignment | ||
Range on Protein: 276-491
Range on HMM: 23-237/239.0
RIQLDRPPGAKISGFINANAVRGFQGNPMRFIVTQAPLSgFESGrvgtqvAFWSMVYQYQAPVVIML---IEPQPHRCTRYWPvpDGNLRSGPFEVRHHG
|. |.. | .|||. .| ..|.| .| || .. .|| || |..| . |..|| || . ..| .||| | . . | .
rvvleklsndphsdyinasylrdydgspkayiatqgcve.issg......dfwrmmwqerrcvivmltglieghkkkchqywp..dstskycnlrvtlrk
FDKHRGFLVSSLSLTLRGKTH-RF-QHICLSGWNEHGLPRSSKSVIALLRYLRNLKV--RGPIVVHDDRGLGPSGVFVASDYCIDQAQAGK-VDVMQAVY
. ... .. .. |.| |. . .. | ..|.|. . .|. | | . . . | |.| |.| .| |. | . ||. | ||... |
tevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcsagvgrtgaflvidamlrqakkqktvdifnyvk
TLRQDRAALVESRAEYQYIHRLVL
..|.|| .|.. .| .|| ||
airedrphmvqtseqyvfihlavl
|
|||||||||
| subfamily_Anemone-PTP-1_pd | Subfamily Anemone-PTP-1 | 276-491 | 3.2e-19 | 64.0 | In-house | 24-238 (239) | alignment | ||
Range on Protein: 276-491
Range on HMM: 24-238/239.0
RIQLDRPPGAKISGFINANAVRGFQGNPMRFIVTQAPLSgFESGrvgtqvAFWSMVYQYQAPVVIML---IEPQPHRCTRYWPvpDGNLRSGPFEVRHHG
|. |.. | .|||. .| ..|.| .| || .. .|| || |..| . |..|| || . ..| .||| | . . | .
rvvleklsndphsdyinasylrdydgspkayiatqgcve.issg......dfwrmmwqerrcvivmltglieghkkkchqywp..dstskycnlrvtlrk
FDKHRGFLVSSLSLTLRGKTH-RF-QHICLSGWNEHGLPRSSKSVIALLRYLRNLKV--RGPIVVHDDRGLGPSGVFVASDYCIDQAQAGK-VDVMQAVY
. ... .. .. |.| |. . .. | ..|.|. . .|. | | . . . | |.| |.| .| |. | . ||. | ||... |
tevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcsagvgrtgaflvidamlrqakkqktvdifnyvk
TLRQDRAALVESRAEYQYIHRLVL
..|.|| .|.. .| .|| ||
airedrphmvqtseqyvfihlavl
|
|||||||||
| 0049772 | (Phosphotyrosine protein) phosphatases II | 262-495 | 7.9e-19 | 64.0 | In-house | 48-281 (314) | alignment | ||
Range on Protein: 262-495
Range on HMM: 48-281/314.0
RELREPRILPSVtTRIQLDRPPGAKiSGFINANAVRGFqgnpMRFIVTQAPLSgfesgrvGTQVAF----------WSMV--YQYQAPVVIM--------
.| ..||| .| .|.. |. |..|||. |.|| ..||.||.||. | | | |.|| .... .. |
dknryldilpad.nrvilpglpvsg.sdyinasyvdgf....lkfIatqgple.......itvvdfreepvlyyngwrmvlrgdlnvrdivmsrdevlad
-------------LIEPQPHRctrywpvpdgnlR----------SgpfevrhhgfD-------KhrgflvsslsltlrgKTHRFQHICLsGWNEHGLPrS
|... .. . . . ...... . .. | .
elsrLdaAlgKtpllildgng............neptaadlellk..........eelydpelf...............erlgikylri.pvpDgsap.l
SKSVIALLRYLRNLKVRGPIVVHDDRGLGPSGVFVASDYCIDQAqagKVDVMQAVYTLRQDRA-----ALVESRAEYQYIHRLVLGYLD
.. . ..|....... ||..|| | | .|.||. .|.. . .|.. .|. .|. | ..|. .|..|.. .| ||.
ledfdeflefieeadkggpvlvHCkaGkgRtgtfvvaaylmkll...gvsleealedvrlkRpinpnpgfieqleqyefilealleylk
|
|||||||||
| 0051082 | (Phosphotyrosine protein) phosphatases II | 287-489 | 2e-18 | 61.9 | In-house | 2-148 (151) | alignment | ||
Range on Protein: 287-489
Range on HMM: 2-148/151.0
ISGFINANAVRGFqgnpmrFIVTQAPLSgfesgrvgtqvAFWSMVYQYQAPVVIMLIEPQ-PHRCTRYWPVPDgnlrsgpfevrhhgfdkhrgflvssls
.|..||.. | |. ......||. .|. ...... ....| ... . |..|.| .
lsdyinfsyvtgg......lyrsggpla...........dflellkelgiktivnlrseeergycpeylpelg...........................
ltlrgktHRFQHICLSGWNEHGLPRSSKSVIALLRYLRNlkV-RGPIVVHDDRGLGPSGVFVASDYCIdQAqagkVDVMQAVYTLRQDRAALVESRAEYQ
... || . .| ..||| | ..|...|..|.. ||..|| |.| .|..|| . .. . |.. .|. .|. | .| . ...
.......ievlhipildwpdpglplsfdavleflellld..kkngpvlvHCsaGkgRTGtlvalylml.lg....vsleealeeyrlkrpgvvqpnqqfl
YIHRL
....
fqlfa
|
|||||||||
| PTPc_DSPc_SM00012 | 397-491 | 2.9e-18 | 61.4 | In-house | 4-104 (105) | alignment | |||
Range on Protein: 397-491
Range on HMM: 4-104/105.0
HICLSGWNEHGLPRSSKSVIALLRYLRNLKV----RGPIVVHDDRGLGPSGVFVASDYCIDQAQAG--KVDVMQAVYTLRQDRAALVESRAEYQYIHRLV
|. .|| .||.|..|.|.. |||.... | ..|.|||. | | .|.||| |....| ... .||. | | ||. |. .|.. ..|....| .
hyhytgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqylflyral
L
|
l
|
|||||||||
| 0043147 | (Phosphotyrosine protein) phosphatases II | 288-487 | 5.2e-18 | 60.8 | In-house | 5-154 (172) | alignment | ||
Range on Protein: 288-487
Range on HMM: 5-154/172.0
SGFINANAVRGFQgNPMRFIVTQAPlsgfesgRVGTQVAFWSMVYQYQAPVVIMLIEPqphrctrywpvpdgnlrsgpfevrhhgfdkhrgflvsslSLT
| .|||. . . |.|||.||.| | || |..... ....| | ..
sdyinasyldlyy.ipdrfiatqgp.......lrntladfwrmlkelgithivnltel.......................................lyd
LRGKTHRFQHICLSGWNEHGLPrSSKSVIALLRYLRN---LKVRGPIVVHDDRGLGPSGVFVASDYCIdqaqaGKVDVMQAVYTLRQDRAALVESRAEYQ
. .. ... .| || | ... .. .|..... |. ||..|| |.| .|..|| .... .... .|| ..|. | |.. |.
pellerlgiqylylpwpDhgvp.llellleflefidellalspggpvlVHCsaGvgRtgtlvaaylml.....lglsleeavalvrekRpgavqnpsqyr
YIH
...
fly
|
|||||||||
| 0046846 | (Phosphotyrosine protein) phosphatases II | 290-493 | 5.2e-18 | 60.9 | In-house | 14-172 (176) | alignment | ||
Range on Protein: 290-493
Range on HMM: 14-172/176.0
FINANAVRGFqgnpmRFIVTQAPLSGfesgrvgTQVAFWSMVYQYQAPVVIMLIEPQ---PHRCTRYWPVpdgnlrsG----Pfevrhhgfdkhrgflvs
.|||| . | |.|.||.|| . | .|. |..... .|..| |.. ..|..|||.
yinanlilgs.....rpiatqgplpr.......tladflemlkelgitavvnlteevelgrlkcpnywpe.......leklgi.................
slsltlrgkthrfqHICLSGWNEHGLPRSsKSVIALLRYLRNLKVRG-PIVVHDDRGLGPSGVFVASDYCIDQaqaGKVDVMQAVYTLRQDRA-ALVESR
... .| .|| | . . .. ||...|. .| |..|| |.| .|..|| . .. . ..| .|....|. | |...
..............qylhlpwpDhgvpdl.elllellefirealkeggpvlVHCsaGigRtgtlvaayllele...kglsveealalvreqRplgavqtp
AEYQYIHRLVLGY
. |..... .| .
eQyrflyefelll
|
|||||||||
| subfamily_Sponge-PTP1_pd | Subfamily Sponge-PTP1 | 289-497 | 1.1e-17 | 59.0 | In-house | 58-262 (267) | alignment | ||
Range on Protein: 289-497
Range on HMM: 58-262/267.0
GFINANAVRGFQGNpMRFIVTQAPLSgfesgrvGTQVAFWSMVYQYQAPVVIMLIEPQPHRCTRYWPVPDGNLRSGPFEVRHHGFDK-HRGFLVSSLSLT
.||| | |.. . ||||| ||. |. |. .. ... ||...| ..|| |. . . | ..| . . .| |
eyinasyvegyktk.nafivtqdplk.......ntitdfltvihdqkvpvivlltkvftdnirlfwPPkmgqakkyqdltvehslekeendyqiitlelk
LRGK-THRFQHICLSGWNEHGLPRS-SKSVIALLRYLRNLKVRGPIVVHDDRGLGPSGVFVASDYCIDQAQ-AGKVDVMQAVYTLRQDRAALVESRAEYQ
.. . .| || . | ....| . . |.||. . |.| || |. | ...|. | .|. . . .|. | .||... .|
fknesahnvtlyyykkwnintnnkpylkplfgilaknqlengnrPlvvacsdGvGrsGtflvidsqleraktegvsdifdflrkirsqriglvdtkeryi
YIHRLVLGYLDGK
|||.|. | .|.
yihellaeyaegr
|
|||||||||
| subfamily_Cele-PTP-18_pd | Subfamily Cele-PTP-18 | 288-498 | 3.5e-17 | 57.1 | In-house | 73-291 (305) | alignment | ||
Range on Protein: 288-498
Range on HMM: 73-291/305.0
SGFINANAVRGfQGNPMRFIVTQAPLSgfesgrvGTQVAFWSMVYQYQAPVVIML---IEPQPHRCTRYWPVPDGNLRS---------GPFEV-RHHGFD
.| || | || ||| ||||| | || | .| . ..|| .| ..|. |.. |.. . || |
heyihanyvst.ptnpkrfictqaple.......ktcadfwymclqdkveaifmlcnllekgakkcleyfaskdkdvlefeekgqkisvkfessvtlkfr
KHRGFLVSSLSLTLRGK---THRFQHICLSGWNEHGLPRSSKSVIALLRYLRNLKvrGPIVVHDDRGLGPSGVFVASDYCIDQAQAGKV--DVMQAVYTL
|. |. |.. | ... .| | . |.| . ... || | .| |||||| |.| .| | .| .|| ||.. | . . .
kdakakvtetvlviegpgekarkvthyhwidwpdrgvpaadlailellekarpsk..gpivvhcsagigrtgsvvmleyildqllagqiiedtdkilqki
RQDRAALVESRAEYQYIHRLVLGYLDGKD
|..| ... |.| ..|...| |. |.
reqrnnsiqtdaqylfvhqvilnyfrkkk
|
|||||||||
| subfamily_Cele-PTP-19_pd | Subfamily Cele-PTP-19 | 291-481 | 1.1e-16 | 55.4 | In-house | 78-268 (301) | alignment | ||
Range on Protein: 291-481
Range on HMM: 78-268/301.0
INANAVRGfQGNPMRFIVTQAPLSgfesgrvGTQVAFWSMVYQYQAPVVIML---IEPQPHRCTRYWPVP-DGNLRSGPFEVRHHGFDKHRGFLVSSLSL
| || . .|.| |||.||.||. |. || |. ||. ..|| .| . ..|. | || .|. | |... . .. .| .|
ihanwipt.sGhphrfiatqgPlk.......ntsedfwamlvqydvekivmlgqkvekleekceeylpvkisekldigrfkikiknkelilnkkiskrtl
TLRGKTHRF-----QHICLSGWNEHGLPRSSKSVIALLRYLRnlKVRGPIVVHDDRGLGPSGVFVASDYCIDQAQAG-KVDVMQAVYTLRQDRAALVESR
.. | .| | | | ..|.|.| . |. .. | . ||||| |.| | |....| . .| .... .|. ||..| | .
evedstgkfatrtvthyqysewtdrgvPkshaelfdlmelvk..ksekPivvhcsaGiGrsvafigteylareveadptieltealkhlrehrwngvqtn
A
s
|
|||||||||
| 0044763 | (Phosphotyrosine protein) phosphatases II | 274-490 | 1.3e-16 | 56.3 | In-house | 4-167 (178) | alignment | ||
Range on Protein: 274-490
Range on HMM: 4-167/178.0
TTRIQLDRPPGAKISGFINANAVRGFqgnpmrFIVTQAPLsgfesgrvgtqVAFWSMVYQYQAPVVIMLIEPQP---HRCTRYWPVPDGnlrsgpfevrh
|| |. ..| | .|||. . .. ......| .... ..... ....| |... . | .||| |
rtrvllsnleglersdyinaseilpg......lylgslpp...........addlellkelgithivnlteelelgflkcdpywpeeag...........
hgfdkhrgflvsslsltlrgkthrFQHICLsGWNEHGLPRSSKSVIALLRYLRNL--KVRGPIVVHDDRGLGPSGVFVASDYCIDQaqagKVDVMQAVYT
.|.... .. || | ... . ......... . ||..|| |.| ||..|| .... . .... .|.
........................iqylhi.pipDhgvpdllehflefvefieealdekggpvlVHCsaGvgRsgtlvaaylmkkl....glsleeaiel
LRQDRAaLVESRAEYQYIHRLV
.|. | |... .......
vrerRp.ivpnpgqlrqLyefe
|
|||||||||
| subfamily_Sponge-PTP9_pd | Subfamily Sponge-PTP9 | 288-495 | 2.8e-16 | 54.1 | In-house | 70-294 (301) | alignment | ||
Range on Protein: 288-495
Range on HMM: 70-294/301.0
SGFINANAVRGFQgNPMRFIVTQAPLSgfesgrvGTQVAFWSMVYQYQAPVVIMLIEPQPH---RCTRYWPVPD-GNLRSGPFEVRHHGFDKHRGFLVSS
.|||. . |.. . .||..|.|. | | || ...|.. ..|. . . .|..||| . . . |||.| . . |.. .
reyinasyidgys.ekkkfiaaqgpmk.......ktlvdfWrliwqekpvsivmvtnlkegtkskceqywpnseaeseefgpftvtlvneqvyPdfvirq
LSLTLRGK-----THR------------FQHICLSGWNEHGLPRSSKSVIALLRY--LRNLKV-RGPIVVHDDRGLGPSGVFVASDYCIDQAQA-GKVDV
|..... ..| . . | ..|. | . |. . |. |. ||.||| . . |||... . ..|..| | |||
lnvkiqdgsnngyierkfkvksdksswdvlqlqvtdWpqdGvvreprtvLqviddvihrqqkigggpvvVHCSdtVsrsGvYcsvsiglEQckaegVVdv
MQAVYTLRQDRAALVESRAEYQYIHRLVLGYLD
.| . ..|. . | | |. . ||
fqvtkavrrskpgaVtTLeqytsiydvidmylq
|
|||||||||
| subfamily_Sponge-PTP6_pd | Subfamily Sponge-PTP6 | 274-492 | 3e-16 | 53.9 | In-house | 62-277 (439) | alignment | ||
Range on Protein: 274-492
Range on HMM: 62-277/439.0
TTRIQLDRPPGAKISGFINANAVRGFQGnPMRFIVTQAPLSgfesgrvGTQVAFWSMVYQYQAPVVIMLIEPQphRCTRYWPVpDGNLRSGPFEVRHHGF
||. |. || | .|||| ..|. . .| ||.| | || .|.. .. ..|| . .||| |.. | ||
htrvtlqeipgvphshyinanyikGyyd.dklyiatqgpkk.......ettddfwrlviekktvtivmltnlv..esykywps.daevcygdiavrvdrn
D-----KHRGFLVSSLSLTLRgKTHRFQHICLSGWNEHGLPRSSKSVIALLRYLR---NLKVRGPIVVHDDRGLGPSGVFVASDYCIDQAQA-GKVDVMQ
||| | | . | . .. | .. .| . |. .|| . . . ||.||| |.| .| .| | ...| .. |||.
ielpnyvirgfkvfnerdtte.kertvlqfhyiawpdknvpaqashvldflrainsandkeeygpvvvhcsagvGrtGtiialdialeqlklenkvdikg
AVYTLRQDRAALVESRAEYQYIHRLVLG
| ||..| .|.. ..| .|. ||
ivkvlrkqrkqmvqalcqyvfiynavle
|
|||||||||
| 0049260 | (Phosphotyrosine protein) phosphatases II | 322-487 | 3.5e-15 | 51.5 | In-house | 20-143 (152) | alignment | ||
Range on Protein: 322-487
Range on HMM: 20-143/152.0
GTQVAFWSMVYQYQAPVVIMLIEPQPH---RCTRYWpvpdgnlrsgpfevrhhgfdkhrgflvsslsltlrgkthrfqHICLSGWNEHGLPRSSKSVIAL
| || |...... ...|| |... | .|. ... | || | .| .. |
ntladfwrmlkelgittivmltellelgklkceqyi..........................................qylhlpwpDhgvpdlsqlllfl
LRYLRN--LKVRGPIVVHDDRGLGPSGVFVASDYCIdqaqaGKVDVMQAVYTLRQDRAALVESRAEYQYIH
|. .. |. ||..|| |.| .|..|| .... .|.. .|| .|. | |.. .....
llfieklaldkggpvlVHCsaGvgRtgtlvaaylml.....lgvsleeavalvrekRpgavpnpgqlrfly
|
|||||||||
| subfamily_Cele-PTP-8_pd | Subfamily Cele-PTP-8 | 275-495 | 7.6e-15 | 49.7 | In-house | 58-272 (288) | alignment | ||
Range on Protein: 275-495
Range on HMM: 58-272/288.0
TRIQLDrppgAKISGFINANAVRgFQGNPMRFIVTQAPLSgfesgrvGTQVAFWSMVYQYQAPVVIML---IEPQPHRCTRYWPVPDGN---LRSGPFEV
||..|. .|.|| | . .. |.| .|||| || .| |. . . ..|| .| .. |.|. |. .. |
trvkls....ddpdfyiaanvvs.sakykrrlicaqaPln.......gtieelWkmllesdveyivmlcellekGkeksaeyfPsklGekarigrlctvv
RHHGFDKHRGFLVSSLSLTLRGKTHR-FQHICLSGWNEHGLPRSSKSVIALLRYLRNLKvrGPIVVHDDRGLGPSGVFVASDYCIDQAQA-GKVDVMQAV
... | .. || | . |... ... | |...|.| . .| . || |..|. ||||| | | .| .. . ..... . . . .
kkkradidklvkvsllriskegeekvivkilhlleWdddgvPenylsplrllevlkslq..kPivvhssaGvGrtgtlililialeslrlddflgirsll
YTLRQDRAALVESRAEYQYIHRLVLGYLD
||..| ... | |.||.|| .|
aklreerfkaiqtemqylyvhrcvleell
|
|||||||||
| subfamily_Cele-PTP-13_pd | Subfamily Cele-PTP-13 | 275-493 | 8.8e-14 | 45.8 | In-house | 52-268 (281) | alignment | ||
Range on Protein: 275-493
Range on HMM: 52-268/281.0
TRIQLDR-PPGAKISGFINANAVRGFQGNpMRFIVTQAPlsgfesgRVGTQVAFWSMVYQYQAPVVIML---IEPQPHRCTRYWPVP-DGNLRSGPFEVR
.|.|| | . . .| || .| . .|.|| | . |. || |..| .. ..|| .| . .|. |.| |. . |
srvqlkvkmpnknstdyihanyirspflk.rgyiltqgp.......kketradfwrmiwqenttaivmlcqfletnrekcaeyfprnahcclqfdklsvs
HHGFDKHRGFLVSSLSLTLRGKTHRFQHICLSGWNEHGLPRSSKSVIALLRYLRNLKvrGPIVVHDDRGLGPSGVFVASDYCIDQAQA--GKVDVMQAVY
. . .. . | |. |.|. | | . .| ||. .. .|| .| | |.| |.| || ..| . ... .. |. | |
yedstvnkslvttrlnlsyegetrlithwlwkewpdwqvpessevmlkilrkirars..tppvihcsagvgrsgtlmaveialqsihshftlpdikqivs
TLRQ-DRAALVESRAEYQYIHRLVLGY
|| ||| |.. .| | ...| .
hlrvtgraasvqtlqqymliwkvlldf
|
|||||||||
| subfamily_CG42327_pd | Subfamily CG42327 | 240-424 | 6.3e-13 | 43.1 | In-house | 8-192 (319) | alignment | ||
Range on Protein: 240-424
Range on HMM: 8-192/319.0
QDDFRTLPLHLASSKSLGEHLLRELREPRILPSVTTRIQLDRPPGAKISGFINANAVRGFQGNPMRFIVTQAPLSGfesgrvgTQVAFWSMVYQYQAPVV
..|| || .|.. . | ...| ||. |.| . . . ...|. |||.. | .| .|..| . .|| .|.. |. |.
aeefrdlPqliaradevPvtskdksrvinvvPlPetrvvlqrigdddkdeyldasyvrGyddapnsyiaaqvsled.......sssdfwrtvweqqsrvi
IMLIEPQP---HRCTRYWPVPD---GNLRSGPFEVRHHGFDKHRGFLVSSLSLTLR-G-KTHRFQHICLsGWNEHGLPRSSKSVIALLRYLRN
. | ... ..|..|.| . .. | . | | . . ...|.| | . .. | | | ..| . ...||.| |.
vqltdlselGikvcaeylPtketldntslyGdilvtlkgrevkdryaistlllkrvdkeesrelthywy.kwleaevPaeeaaliamllevrs
|
|||||||||
| subfamily_Choan-PTP-4_pd | Subfamily Choan-PTP-4 | 260-413 | 3.5e-12 | 40.8 | In-house | 33-184 (297) | alignment | ||
Range on Protein: 260-413
Range on HMM: 33-184/297.0
LLRELREPRILPSVTTRIQLDRPPGAkiSGFINANAVRGF-QGNPMRFIVTQAPLSGfesgrvgTQVAFWSMVYQYQAPVVIMLIEPQ---PHRCTRYWP
||. | || .||..| | . . .|||. | . .....|..| ||| | || .|.. . |..|. . | ..|. |||
slrknryrdilatddtrvkllrvite..rdyinadyvvfpdeeadlkyilaqGplsa.......tvddfwtlvaeqdvrvivmvaklqedGrdkcapywp
VPDG-NLRSGPFEVRHH--GFDKHRGFLVSSLSLTLRGKTHRFQHICLSGWNEHGLPRSSK
.. .|..| . | . |.. .. | | | .. .|. .| .||.| .
svvqerlkagdvvveflsstsdefdrviltelqliyrsesrvvrhvqflswpdhGvpsdle
|
|||||||||
| subfamily_ptpA1_pd | Subfamily ptpA1 | 235-447 | 1.2e-11 | 39.0 | In-house | 19-248 (418) | alignment | ||
Range on Protein: 235-447
Range on HMM: 19-248/418.0
TITSLQDDFRTLPLHLASSK-SLG--EHLLRELREPRILPSVTTRIQLDRPPGAKISGFINANAVRGfqGNPMRFIVTQAPLSgfesgrvGTQVAFWSMV
| ....|| | . |. | | .| . | ||| ||.|| . . | .|||| . | | .||.|| || | || ||
cihkikeefrlleesvgpsetsegdkkhntsknrytnilpvnhtrvqlkkiqdkegsdyinanyidg..aypkqfictqgplp.......ntiadfwrmv
YQYQAPVVIMLIE---PQPHRCTRYWPVP----------DGNLRSGPFEVRH--HGFDKHRGFLVSSLSLTLRGKTHRFQHICLSGWNEHGLPRSSKSVI
.. .. ...|| .| |||| .|| | . | | | . . ||. |.|. . || .| .| .. .
wenrcriivmlsresencrikcdrywpeqiggeqfsiygngnevfgtysvelveviqdpereiitrnirltfegetrditqyqyegwpdhnipdhtqpfr
ALLRYLRNLKV--------RGPIVVHDDRGLGPSGVFVA
||. . | . ||.|| |.| .| |..
qllhsitnrqnqiipssdrnvpiivhcsagvgrtgtfct
|
|||||||||
| subfamily_Urchin-PTP-4_pd | Subfamily Urchin-PTP-4 | 393-496 | 4.8e-11 | 36.7 | In-house | 278-387 (392) | alignment | ||
Range on Protein: 393-496
Range on HMM: 278-387/392.0
HRFQHICLSGWNEHGLPRS--SKSVIALLRYLR---NLKVRGPIVVHDDRGLGPSGVFVASDYCIDQA-QAGKVDVMQAVYTLRQDRAALVESRAEYQYI
| . || || . ..|.. |.| .. | | |.|| | | .||| .. || | . ||..|.| || || |.. || ..
htvtqyqfhgwpkhgsdqqsgarsllkliravkgstnskkefsilvhclsgagrtgvfctameciaqiaegdsvdifqtvkilradrmqfvqteeeyafv
HRLVLGYLDG
. .. ||
ydvireylht
|
|||||||||
| subfamily_Cele-PTP-7_pd | Subfamily Cele-PTP-7 | 290-486 | 9e-11 | 35.8 | In-house | 63-280 (302) | alignment | ||
Range on Protein: 290-486
Range on HMM: 63-280/302.0
FINANAVRgFqgNPMRFIVTQAPLSGFESGRVGT----------QVAFWSMVYQYQAPVVIML---IEPQPHRCTRYWPV-PDGNLRSGPFEVRH-----
||||| .. . . ...|..| |. | | . . . .|... ||. .|. | .| . ..|. |. .|.|. | . |.
finanvlk.l..deikwimaqGpmdGtekkekvskkpivpkkstlekhwalieqynvaivvqlcsfvedeekkcaeyysdkvggelkfgrytvktvsvkt
--HGFDKHRGFLVSSLSLTLRGKTHRF----QHICLSGWNEHGLPRSSKSVIALLRYLRNLKVRgpIVVHDDRGLGPSGVFVASDYCIDQAQAGKV-DVM
. | ..| . .. .. |... . . |.| .|| |. ... . .|.. | ..|| |.| .| .|| | |. . || |..
dleeftdkksfklytveiknekkkkkvkktvdilafsawpdhGapkeaytaldilkfcesykkn..vlvhcsaGvGrtGtlvaikyGiqlcskkkvtdll
QAVYTLRQDRAALVESRAEYQYI
. | .|| | | . |.
sivlpvrqcryGavqdeqqliyl
|
|||||||||
| subfamily_CG42327_pd | Subfamily CG42327 | 428-492 | 9.5e-11 | 35.9 | In-house | 247-313 (319) | alignment | ||
Range on Protein: 428-492
Range on HMM: 247-313/319.0
RGPIVVHDDRGLGPSGVFVASDYCIDQAQAG--KVDVMQAVYTLRQDRAALVESRAEYQYIHRLVLG
.||.||| | | .|. .||| | . . ||. | |. .|.||| | .. |..|.. .
qGPlvvhcsdGvGrtGlviasdiairsleeskrsvdiPqlvssvrrdrasavltkeqyefiykvlse
|
|||||||||
| subfamily_Cele-PTP-9_pd | Subfamily Cele-PTP-9 | 325-478 | 9.6e-11 | 36.2 | In-house | 42-205 (255) | alignment | ||
Range on Protein: 325-478
Range on HMM: 42-205/255.0
VAFWSMVYQYQAPVVIMLIEPQ---PHRCTRYWPVP-DGNLRSGPFEVRHHGfdKHRGFLVSSLSLTL----RGKTHRFQHICLSGWNEHGLPRSSKSVI
.|. .. | .. ||.|| . . .| .|.|. |. |. .| .. | .|. . ||| .| || |. |. .. .
dkfyqtivqtktevvvmlcdfaeegvekcssyfplekdeklkladvnvtttk..ssadvvlrtleitstlgekkkthtvkhysykGWieknaPelareil
ALLRYLRNLKvrgPIVVHDDRGLGPSGVFVASDY--C-----IDQAQAGKVDVMQAVYTLRQDRAALVE
.|. |. | ..||| . | | | || .. .|.......| .. . ||. |.. ..
nilkvvrdsk...svvvhCstGiGrsaafvlaelvyqkmirsldttetveldylslleelrskrkraih
|
|||||||||
| 0048076 | (Phosphotyrosine protein) phosphatases II | 380-491 | 9.7e-11 | 37.0 | In-house | 32-140 (145) | alignment | ||
Range on Protein: 380-491
Range on HMM: 32-140/145.0
LVSSLSLTLRGKTHRFQHICLSGWNEHGLPRSSKSVIALLRYLRNLKVRG-PIVVHDDRGLGPSGVFVASDYCIDqaqaGKVDVMQAVYTLRQDRAALVE
.| .|. .|.. .. ... .| || | ... ....|...... .| |..|| |.| .|..|| . .. .|.. .|. .|. | |.
tvlnltselellerlgiqylylpwpDhgvpdllellleflefieealkeggpvlVHCsaGvgRtgtlvaaylmll....lgvsleealelvrsqrpgavp
SRAEYQYIHRLVL
. ........|
npgqlrflyefel
|
|||||||||
| subfamily_eak_pd | Subfamily eak | 288-425 | 7.9e-10 | 32.6 | In-house | 78-210 (332) | alignment | ||
Range on Protein: 288-425
Range on HMM: 78-210/332.0
SGFINANaVRGFQGNPMRFIVTQAPlsgfESGRVgtqVAFWSMVYQYQAPVVIMLIEP---QPHRCTRYWPVPD-GNLRSGPFEVRHHGFDKHRGFLVSS
|.||| . | ..|.| .. . .| ||| ||.. ..| ...|.| . . .|.| .|. | ..| | |. . .
lGyinas.laefsevGrkyiltGia....sedkv...fafwqmvleqkspaivqlledvelkleksdkyfpdktreelkfGildverkefvkrniletrl
LSLTLRGKTHRFQHICLSGWNEHGLPRSsKSVIALLRYLRNL
| |. .||| .| . || | ||. . .|| . ...
lelskGnethrvlhykvfGwtettlpky.edflalrkvmkev
|
|||||||||
| 0048179 | (Phosphotyrosine protein) phosphatases II | 397-488 | 1.2e-09 | 33.6 | In-house | 51-139 (144) | alignment | ||
Range on Protein: 397-488
Range on HMM: 51-139/144.0
HICLSGWNEHGLPRSSKSVIALLRYLRNL-KVRGPIVVHDDRGLGPSGVFVASDYCIdqaqAGKVDVMQAVYTLRQDRAALVESRAEYQYIHR
... .| || | ... ....|...... . ||..|| |.| .|..|| . .. .... .|.. .|. | |... ......
qylhlpwpDhgvpdllellleflefieealeeggpvlVHCsaGvgRtgtlvaaylmk....klglsleealalvrsrrpgavpnpgqlrfLle
|
|||||||||
| subfamily_Urchin-PTP-2_pd | Subfamily Urchin-PTP-2 | 305-394 | 2.2e-09 | 31.2 | In-house | 237-319 (440) | alignment | ||
Range on Protein: 305-394
Range on HMM: 237-319/440.0
RFIVTQAPLSgfeSgrvgTQVAFWSMVYQYQAPVVIMLIEPQPHRCTRYWPVPDGNLRSGPFEVRHHGFDKHRGFLVSSLSLTLRGKTHR
|| || || | | . || .|..|. .||| . . . |. |||| . ||| | |.| .. | .| | . . |
afiatqmpld...s....tvldfwrlvhdyristiimlnqlndktcsiywpvntrsvtfgpftvghkgsenmnrvkvrtlelkykeevhe
|
|||||||||
| subfamily_Cele-PTP-11_pd | Subfamily Cele-PTP-11 | 301-498 | 3.1e-09 | 30.9 | In-house | 79-280 (312) | alignment | ||
Range on Protein: 301-498
Range on HMM: 79-280/312.0
GNPMRFIVTQAPLSgfesgrvGTQVAFWSMVYQYQAPVVIML---IEPQPHRCTRYWPVPDG--NLRS--------GPFEVRHHGFDKHrGFLVSSLSLT
.| ||..||.|| | . || .. . .|.| .| ..|..| | .| |. . || | . .
tkperfvctqgple.......ntcthfwqlalslgstsiillcgfvedgsekcakyisdivgfvdledhrvyteycteieiggkskdki.thrvlkvvvk
LRGKTHRFQHICLSGWNEHGLPRSSKSVIALLRYLRnlKVRGPIVVHDDRGLGPSGVFVASDYCIDQAQ-AGKVDVMQAVYTLRQDRAALVESRAEYQYI
|. ...| . | .||.| | . || .. | . |.. | |.| .| .. . | . | .| .. ||.||| |. ..| |
atgqesklnhyqwaswpdhgmpdscdtalrllsavk..kdkkpviahcsagvgrtgtlaliesmiaalrhprkqnvkdsfvllrkdrarsvrvfpqyvya
HRLVLGYLDGKD
| || .| |
lrcvleflyskg
|
|||||||||
| subfamily_hpo-7_pd | Subfamily hpo-7 | 325-477 | 3.1e-09 | 31.1 | In-house | 48-210 (263) | alignment | ||
Range on Protein: 325-477
Range on HMM: 48-210/263.0
VAFWSMVYQYQAPVVIMLIE---PQPHRCTRYWPVP-DGNLRSGPFEVRHHGFDKhrGFLVSSLSLTL----RGKTHRFQHICLSGWNEHGLPRSSKSVI
.|.... | .. ||.|| . . .| .|.|. |. .. .| . |. .| |. . ||| ..| || |. |. .....
dkfyqtivqtktevvvmLcDfneegvekcssyfPlekdekqklanvnvcttkvqs..dvllktlellstlgeKkkthtvkhysykgWiekndpelareil
ALLRYLRNLKvrgPIVVHDDRGLGPSGVFVASDY--C-----IDQAQAGKVDVMQAVYTLRQDRAALV
.|. ||.| ..||| | | | |. . .|.......| .. . ||. |.. .
nilkvarnsk...slvvhcstGiGrsaafsvaElvyqkmirsldttstveldylsLleelrssrkrai
|
|||||||||
| subfamily_Cele-PTP-15_pd | Subfamily Cele-PTP-15 | 293-497 | 4.6e-09 | 30.6 | In-house | 64-273 (285) | alignment | ||
Range on Protein: 293-497
Range on HMM: 64-273/285.0
ANAVRGFQGNPMRFIVTQAPLSGfesgrvgTQVAFWSMVYQYQAPVVIML---IEPQPHRCTRYWPVPDGNL-RSGPFEVRHHGFDK--HRGFLVSSLSL
|. .| . .| || || | || |.|| . |.|| .| .|. |.| |.. . | .|. . | .. .|..
aswmrmpgkdqstyittqgplpe.......tlsdfwhmiyqekiayvlmlctlfeggvekcalyypeklgevvkfgkyeitlteckeeaiagtilnaltv
TLRG----KTHRFQHICLSGWNEHGLPRSSKSVIALLRYLRNLKVR-GPIVVHDDRGLGPSGVFVASDYC-IDQAQAGKVDVMQAVYTLRQDRAALVESR
. . ..|. . | .. | .. .| | ....... . ||.|| |.| . || ||. | . ...... | .| | |.|.
intedasseplymnhvqvpwwpdqlapedarpmielykwvkkvnpkekpicvhcsagvgrtatfvgidyatirimenpniemldivremramrfqavqsh
AEYQYIHRLVLGYLDGK
.. ... ... |. |.
mqflflyvvlmeyfige
|
|||||||||
| subfamily_Urchin-PTP-2_pd | Subfamily Urchin-PTP-2 | 397-494 | 2.4e-08 | 27.7 | In-house | 93-194 (440) | alignment | ||
Range on Protein: 397-494
Range on HMM: 93-194/440.0
HICLSGWNEHGLPRSSKSVIALLRYLRNLK---VRGPIVVHDDRGLGPSGVFVASDYCIDQAQ-AGKVDVMQAVYTLRQDRAALVESRAEYQYIHRLVLG
. || ..|.|. . |. ... . . . ||..|| | | .|| .| | . .|. . ..|.. . ..|..| .|.. .| ..| ||
qyhyqgwpdkgvpkfagpvlkmiqdvnesqekagngpllvhcsagagrtgviiavdsilreakrsdqidifsfinsmrnnrpqmvqtpeqyafvheavle
YL
|
gl
|
|||||||||
| subfamily_Nvec-PTP-3_pd | Subfamily Nvec-PTP-3 | 322-488 | 3e-08 | 28.1 | In-house | 15-197 (198) | alignment | ||
Range on Protein: 322-488
Range on HMM: 15-197/198.0
GTQVAFWSMVYQYQAPVVIMLIEPQPHRC---TRYWPVPD-GNLRSGPFEVRHHGFDKHRGFLVSSLSLT----LRGKTHRFQHICLSGWNEHGLPRSSK
| || ||.. . ..|. . | . |||. . | . | . | . . . ...| || | | .. |.|. | .
etladfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqftswkekttpnval
SV---IALLRYLR--NLKVRGPIVVHDDRGLGPSGVFVASDYCIDQ---AQAGKVDVMQAVYTLRQDRAALVESRAEYQYIHR
| .| . . . |..|| | | .||||| | . ... ||... ||| | .. | |..|..
fvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiyq
|
|||||||||
| subfamily_Anemone-PTP-3_pd | Subfamily Anemone-PTP-3 | 322-488 | 3.3e-08 | 27.9 | In-house | 16-198 (199) | alignment | ||
Range on Protein: 322-488
Range on HMM: 16-198/199.0
GTQVAFWSMVYQYQAPVVIMLIEPQPHRC---TRYWPVPD-GNLRSGPFEVRHHGFDKHRGFLVSSLSLT----LRGKTHRFQHICLSGWNEHGLPRSSK
| || ||.. . ..|. . | . |||. . | . | . | . . . ...| || | | .. |.|. | .
etmadfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqftswkekttpnval
SV---IALLRYLR--NLKVRGPIVVHDDRGLGPSGVFVASDYCIDQ---AQAGKVDVMQAVYTLRQDRAALVESRAEYQYIHR
| .| . . . |..|| | | .||||| | . ... ||... ||| | .. | |..|..
fvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiyq
|
|||||||||
| subfamily_Cele-PTP-4_pd | Subfamily Cele-PTP-4 | 400-497 | 3.9e-07 | 23.8 | In-house | 188-288 (302) | alignment | ||
Range on Protein: 400-497
Range on HMM: 188-288/302.0
LSGWNEHGLPRSSKSVIALLRYL--RNLKVRGPIVVHDDRGLGPSGVFVASDYCIDQAQAGK-VDVMQAVYTLRQDRAALVESRAEYQYIHRLVLGYLDG
|. |... | . ..|. . .. |. ..|. .| | |.|.. ... |.|| . . . | ..|..|.. |.| | ... .| |.
ltnWkqkkvpvkyaeliktaakvfakkikadentvivSknGaGRagafltlavaveklqkgkepnikeivksiRsqRpravdslkQyvslyialllyikk
K
|
k
|
|||||||||
| subfamily_Cele-PTP-14_pd | Subfamily Cele-PTP-14 | 394-503 | 9.9e-07 | 22.6 | In-house | 191-299 (310) | alignment | ||
Range on Protein: 394-503
Range on HMM: 191-299/310.0
RFQHICLSGWNEHGLPRSsKSVIALLRYLRNLKvRGPIVVHDDRGLGPSGVFVASDYCIDQAQAG-KVDVMQAVYTLRQDRAALVESRAEYQYIHRLVLG
| . | | . |.| | | | ... || ||| | . .| || .. ||... | |||. . . |...|| ... .| .|.|. .
rvslikwpnwpdrgvpde.kchtvpqrllaqvr.hgpcvvhcsagkdrlyvvvalklkidkldrglkvdaeevktellksraiciqtelqyliidrvrii
YLDGKDQKGAA
. |....
fargetevaek
|
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