Gene Myosin-PTP-1 in Monosiga brevicollis

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily Myosin-PTP
Protein sequence
ID Type Fasta BLAST phosphatome Note
MbreP060_AA protein Get Run
MbreP060_AA_1241-1496 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
Myosin_head Myosin head (motor domain) 253-1019 1.2e-179 584.9 Pfam-A 2-689 (689) alignment
Range on Protein: 253-1019
Range on HMM: 2-689/689.0
DNLARYNDITEDYIVGTLQLRYRDGLIYTAVGDILVAVNPYQEVGLYSDEWKAAYMFDSDISRRPHIFGIALRAFRAMANEGVDQSCVISGESGAGKTET
..||. . ..|. ..  |. || ..|||| .|..|..||||... .||.|  ..|.  .     |||| .| .|.|.| ... .||.|||||||||||| 
edlaaltqlsetsllenLkkrytgdliytysGlvlisvNpykklpiyseeiieeykgkkreelppHifalAdeAYrsmlrrkenqsivisGESgagkTea

AKLFLRHLLDLSGGNIQELLHRYDLMQFSINNLLEAFGNAQTRINRNSSRFGKYVELGFSRDNHALGVMLSTYLLEKSRVvhqscpshvmhnarlppntG
.|. ...|. .|. . .   ..   .  . | .|||||||.|  | |||||||..|. |  . .  |  ..|||||||||                    
tkkliqylasvssstekaeeeeleskilqanpileafgnaktlrnnnssrfGkfleiqfdasgsivGakietylLeksRv...................v

LQSEGERNFHIFYYLVEGLSDAERKQYHLDgTIRDFAYINGGVtpyerartgrQSDLAGMPAETplLYRELIDYMKLAGFSAIELEYIHQMLALVLLLGN
 |..|||||||||.|..|.|..|.....|. . ...||.. .           |... |.       ..|. . .|  |... | . | ..|| .| |||
sqekgeRnFhiFYqLlagasaeekeelkLk.daksYaylsqsg..........qlkvdgidDae..efketrkalkilglkeeeqreifkvlAaiLhlGn

IDFDRDSRGKGQRFMKLDVigpLEAVAALLGCTVSDVGHGLASTIMVTRGDTIVKENTQQDAKDARDAMAKALYGRLFFWVVNKVNLLLGLHDmSQVKRT
|.|  | ...   . . ..   ||..|.|||  |... . | .  . |. ....|  ... |.|||||.|||.| ||| |.|.|.|  |  .. .... .
ikfkedqkeeqavvedkee...lekiaellgvdveelekallkrriktgrevvtkalnkeqaedardaLakaiYsrLfdwivekiNealsake.dkaaav

IGVLDIFGFESLKVNSLEQMCINIANEQLQEFFNSHIFAWQQQELTEEGIDASFVSF-TDNSSLLNLFIGNPVGLLNLVDEQSRFPNADDQSLIDKLANQ
||||||.|||  . ||.||.|||.|||.||.||| |||   |.|. .|||. ..... .||.  ..|   .|.|.| |.||..|.|.|.|.|...|| ..
iGvlDiaGFeifeknsfeqlciNyanEkLqqffnehifkleqeeyeregieweeidygldnqavidLiekkpaGilsllDeecrlpkatdesflekllet

LSQHNTIFTKGK---KSKKLHFTIQHYAGPIDYDVTGWIEKNRDSLTPSVTSLLRESQNVLVRDLFSTSQTLFggltanepqalrdqrqenarelikvlr
 ..... |.| .   . .. .||..|||| ..|...|..|||.| |......||..|.. ||..||.  ..                             
feskhpkfskkrlskaraessftvkHyAgeVeYsaegflekNkdplsedlvellkssssslvaelfkeeelae...........................

rsfwnpskqekasenrrqvlRANGGGGGGRMQRLDSQpslPVSKTVKKASTTICASFKASLNDLVTKLSQTEPSFVRCIAPNHDQKPNDYVEAEVLRQLR
                      .     .....|.|.     ....||  .|. . ||.||. |...|..|.| ||||| ||...|...  .  || ||.
....................dfeeeeaaaesaklgsa...kgksgkkkkfetvgsqfkeslgelmktLrstnphfvrCikPneekkakkfdsklvleqlk

YTGVMETIRIRREGFAVRLFFDEFVARYRLLHYRFK---QGLAAEPVDACKQILSSFSEDPSEWQLGKSKVFLK
. ||.|.|||||.||. |. ||||. ||.||  .     . |  .  .||..||.. . | .|...||.|||..
clGvlegirirraGfpsriafdefaerykllaekelvklselvgdekkacekilkeleldkeeyrvGktkvFfr

0050432 (Phosphotyrosine protein) phosphatases II 1249-1496 4.5e-73 241.6 In-house 68-299 (308) alignment
Range on Protein: 1249-1496
Range on HMM: 68-299/308.0
AAQLCRYKNIVPNMDTVVKIdplfennvKvENSDFINANWVRGF--DGRQSYIATQGPKPNTIDHFWRMIIQHEVPLIIMATNLVEGDKIKCHRYWALF-
   ..|||.|.|.  . ||.        . |.||.|||..|.|.  . .. .||||||.|||...||||. ...|..|.| |.||| ...||..|| |  
nkdkNrykdilpydhsRVkl........d.egsdYInAsyvdgyssklprkfIatqgPlpntvedFwrmvweqnvrvIvmLtklvengrekcaqYwplel

-DGIKGQekdpnllvteSGIRVTTEEVAKSRDFILRTFRLEW--NDKEHFVKHLALNNWPDYGVPSSPRAVLRAIEVARDIRyrnPGQPIVVHCSAGVGR
 .|..             ...||. .. .  |...||..|..  ......|.|.   ||||.|||.||...|. .| .|. .   || ||||||||||||
gggsley..........gkftvtllseevlddytvrtleltnlgdgesrtvthfhytnWpdhgvPpspeilldflelvrksl...pggpivVHCsaGvGR

TGILVAVDIGIDMLLAGRRVNLTSIVQHMREDRGGMLQTFPQYEFAFKAIGSFA
|| ..|.|. ...| ....|.. ..|...|| | || ||. ||.| ..|.  ..
tGtfialdllleqlekeggvdvfeavkklReqRpgmvqtpeqylflyralleyl

0051299 (Phosphotyrosine protein) phosphatases II 1249-1493 9.8e-72 237.1 In-house 49-283 (288) alignment
Range on Protein: 1249-1493
Range on HMM: 49-283/288.0
AAQLCRYKNIVPNMDTVVKIDPLFEnnvkVENSDFINANWVRGFDGRQSYIATQGPKPNTIDHFWRMIIQHEVPLIIMATNLVEGDKIKCHRYWALfDGI
  . .||..|.|. .. ||. .| .    ||.||.|||....|..  . .||||||.|||...||||. ...|..|.| |.||| ...||..|| | .| 
nleknRysdilpydhsRVkLsvldg....vegsdYinAsyidgynlkrkfIatqgPlpntvedFWrmvweqnvrvIvmltklvelgrekcaqYwpl.ggs

KGQEKdpnllvtesgIRVTTEEVAKSRDFILRTFRLE------WNDKEHFVKHLALNNWPDYGVPSSPRAVLRAIEVARDIRYrNPGQPIVVHCSAGVGR
.  ..          |.||. .. .  |...||....      .......|.|.   ||||.|||.||...|. .. .|. .  ..| |.||||||||||
ltygd..........itvtllseevlddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpdspellldflrlvrkala.sgggpvvVHCsaGvgR

TGILVAVDIGIDMLLAGRRVNLTSIVQHMREDRGGMLQTFPQYEFAFKAIG
|| ..|.|. ...|.....|.. ..|...|| | || ||. ||.| ..|. 
tgtfialdllleqlekeggvdvleavkrlreqRpgmvqtpeqyrfvyeall

0046845 (Phosphotyrosine protein) phosphatases II 1250-1496 2.6e-71 235.6 In-house 29-274 (284) alignment
Range on Protein: 1250-1496
Range on HMM: 29-274/284.0
AQLCRYKNIVPNMDTVVKIDPLFENnvkVENSDFINANWVRGF-----DGRQSYIATQGPKPNTIDHFWRMIIQHEVPLIIMATNLVEGDKIKCHRYWAL
  ..|||.|.|. .. ||...| ..   .|.||.|||..|.|.     . .. .||||||.|||...||||. ...|..|.| |.||| ...||..|| |
lsknRykdilpydhsRVklksldgd...ledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweqnvrvIVmltelvengrekcaqYwpl

FDGIKGQekdpnllvteSGIRVTTEEVAKSRDFILRTFRLEW---NDKEHFVKHLALNNWPDYGVPSSPRAVLRAIEVARDIRYR-NPGQPIVVHCSAGV
 .. .             ...||. .. .  |...||..|..   ......|.|.   .|||.|||.||. .|. .. .|... . ..| ||||||||||
egevlty..........gdftvtllseevkddytvrtleltnlgytgesrtvthfhytswpdhgvppspedlleflrlvrellenlpgggpivVHCsaGv

GRTGILVAVDIGIDMLLAGR---RVNLTSIVQHMREDRGGMLQTFPQYEFAFKAIGSFA
|||| ..|.|. ...| ...   .|.. ..|...|| | || ||. ||.| ..|.  ..
gRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyealleyl

DSPc_SM00195 1251-1494 9.4e-70 230.3 In-house 28-260 (263) alignment
Range on Protein: 1251-1494
Range on HMM: 28-260/263.0
QLCRYKNIVPNMDTVVKIDPLFENnvkvENSDFINANWVRGFDGRQSYIATQGPKPNTIDHFWRMIIQHEVPLIIMATNLVEGDKIKCHRYWALFDgikg
.  |||||.|...| ||...  ..    |.||.||||...| . ...|||||||.|.|...||||.....|..|.| |. .| .|.||.|||        
sknRyknilpydhtrVklkkeekk....egsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlteeeengkekcdrywpees....

qekdpNLLVTESGIRVTTEEVAKSR-DFILRTFRLEWND--KEHFVKHLALNNWPDYGVPSSPRAVLRAIEVARDIRYRNpGQPIVVHCSAGVGRTGILV
     .   |   |.|.. || | . ..||||..|. ..  ....|...  .|||| |||.|.. ||. .....  . ..  .||||||||||||||..|
.....ggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkksksts.sgpivVhCsaGvgRtgtfv

AVDIGIDMLLAGRRVNLTSIVQHMREDRGGMLQTFPQYEFAFKAIGS
..|| .. | .. .|.. .||...|. | || ||. || |. .||  
tidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaile

PTPc_SM00194 1251-1494 9.4e-70 230.3 In-house 28-260 (263) alignment
Range on Protein: 1251-1494
Range on HMM: 28-260/263.0
QLCRYKNIVPNMDTVVKIDPLFENnvkvENSDFINANWVRGFDGRQSYIATQGPKPNTIDHFWRMIIQHEVPLIIMATNLVEGDKIKCHRYWALFDgikg
.  |||||.|...| ||...  ..    |.||.||||...| . ...|||||||.|.|...||||.....|..|.| |. .| .|.||.|||        
sknRyknilpydhtrVklkkeekk....egsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlteeeengkekcdrywpees....

qekdpNLLVTESGIRVTTEEVAKSR-DFILRTFRLEWND--KEHFVKHLALNNWPDYGVPSSPRAVLRAIEVARDIRYRNpGQPIVVHCSAGVGRTGILV
     .   |   |.|.. || | . ..||||..|. ..  ....|...  .|||| |||.|.. ||. .....  . ..  .||||||||||||||..|
.....ggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkksksts.sgpivVhCsaGvgRtgtfv

AVDIGIDMLLAGRRVNLTSIVQHMREDRGGMLQTFPQYEFAFKAIGS
..|| .. | .. .|.. .||...|. | || ||. || |. .||  
tidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaile

0036941 (Phosphotyrosine protein) phosphatases II 1248-1496 2.9e-69 229.0 In-house 38-277 (297) alignment
Range on Protein: 1248-1496
Range on HMM: 38-277/297.0
NAAQLCRYKNIVPNMDTVVKIdplfennvKVENSDFINANWVRGFDGRQSYIATQGPKPNTIDHFWRMIIQHEVPLIIMATNLVEGDKIKCHRYWALFDG
.  ...|||.|.|. .| ||.        . |.||.|||..| |.|  . .||||||.|||...||||. .. |. |.| |.||| ...||..|| |  |
enleknRykdilpydhtRVkl........ddegsdYinAsyvdgydlkrkfIatqgPlpntvedFWrmvweqnvtvIvmltelvelgrekcaqywpleeg

IKGQEKDpnllvtesgIRVTTEEVAK--SRDFILRTFRLEW--NDKEHFVKHLALNNWPDYGVPSSPRAVLRAIEVARDIRYRN-PGQPIVVHCSAGVGR
   . .|         ..||. .| .  . |..|||....   |.....|.|.   .|||.|||.||. .|. || .|...    .| |..|||||||||
esltygd.........ftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfielvrkvlkllpsggpvlVHCsaGvgR

TGILVAVDIGIDMLL---AGRRVNLTSIVQHMREDRGGMLQTFPQYEFAFKAIGSFA
.| ..|.|. ...|      ..|.. ..|...|| | |. ||. ||.|   |.  . 
sgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallell

0047943 (Phosphotyrosine protein) phosphatases II 1249-1492 6.8e-69 227.7 In-house 38-268 (273) alignment
Range on Protein: 1249-1492
Range on HMM: 38-268/273.0
AAQLCRYKNIVPNMDTVVKIdplfennvKVENSDFINANWVRGFDGRQSYIATQGPKPNTIDHFWRMIIQHEVPLIIMATNLVEGDKIKCHRYWALFDG-
  ...|||.|.|. .. ||.        . ..||.|||..|.|..  . .||||||.|||...||||. .. |..|.| |.||| ...||..|| |  | 
nkdknrykdilpydhsrvkl........gdggsdyinAsyvdgynlkrkfiatqgPlpntvedfwrmvweqnvrviVmLtelvelgrekcaqYwplegge

-IKGQEKdpnllvtesgIRVTTEEVAKSRDFILRTFRLEW--NDKEHFVKHLALNNWPDYGVPSSPRAVLRAIEVARDIRYRN-PGQPIVVHCSAGVGRT
  .  .|          ..||. .. .  |...||..|..  ......|.|.   .|||.|||.|.  .|. ||..|...  .  . |.|||||||||||
lsltygk..........ftvtllseetkddytvrtleltnlgtgesrtvthfhytgwpdhgvppslesllefielvrkalealpsngpvvVHCsaGvgRt

GILVAVDIGIDMLLAGRRVNLTSIVQHMREDRGGMLQTFPQYEFAFKAI
| ..|.|. .|.| ....|.. ..|...|. | || ||. ||.|  .|.
gtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrflyeal

0040438 (Phosphotyrosine protein) phosphatases II 1251-1496 1.7e-68 226.6 In-house 45-276 (317) alignment
Range on Protein: 1251-1496
Range on HMM: 45-276/317.0
QLCRYKNIVPNMDTVVKIDPLFEnnvkVENSDFINANWVRGFDGRQSYIATQGPKPNTIDHFWRMIIQHEVPLIIMATNLVEGDKIKCHRYWALfDGIKG
...||..|.|. .. ||. || .    ...||.|||..| |.. .. .||||||.|||...||||. .. | .|.| |.|.| ...||..|| | .. . 
dknrypdilpydhsRVkLsplgg....dldsdYInAsyvdgpnlkrkfIatqgPlpntvedFwrmvweqgvtvivmLteleelgrekcaqYwpl.getlt

QEkdpnllvtesGIRVTTEEVAKSRDFILRTFRLEW--NDKEHFVKHLALNNWPDYGVPSSPRAVLRAIEVARDIRYrNPGQPIVVHCSAGVGRTGILVA
 .          ...||. .. .  ...|||...|   ......|.|.   .|||.|||.||. .|. .| .|. .  .|| |..||||||||||| ..|
yg..........dftvtllseeelagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfleavreale.dpggpvlVHCsaGvgRtGtfia

VDIGIDMLLAGRRVNLTSIVQHMREDRGGMLQTFPQYEFAFKAIGSFA
... ...|  ...|.....|...|| |.|. ||. ||.|  .|.  . 
aylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalleyl

subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 1235-1497 4.5e-67 220.9 In-house 4-265 (270) alignment
Range on Protein: 1235-1497
Range on HMM: 4-265/270.0
LPLNLGNLADLPKNA--AQLCRYKNIVPNMDTVVKIDPLFENnvkvENSDFINANWVRGFDGRQ-SYIATQGPKPNTIDHFWRMIIQHEVPLIIMATNLV
|. .  .  |||. |  ..| ||..|.|.  | |....| |.    ... .||||.||||||.. .|||..||.|.|. .|||||....|. |.|.|.|.
ldkeetsesdlpeaargkklnRyadiLPsPatRvrleeleed....sataYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgle

EGDKIKCHRYWALfdgikgqEKDPNLLVTESGIRVTTEEVAKSRDFILRTFRLEWNDKEHFVKHLALNNWPDYGVPSSPR------AVLRAIEVARDIRY
|  . || |||.        |.. .. ...  |.|.... .|.. .||.  ||| . .|. . |   |.||| |||...        .|. ..  |  . 
EkgrkkCerYWpa.......epkekvkledgkikvlalseekeegyiltrlrleekgeerrlvHfwyntWpdhgvpreedsslstdqllkmlravrrsek

RN-PGQPIVVHCSAGVGRTGILVAVDIGIDMLLAGRRVNLTSIVQHMREDRGGMLQTFPQYEFAFKAIGSFAR
.   ..|..|||||||||||.|.|.||.. .|   ..|....|....|.||  ..|.  ||||..||.  .|.
eldkaePllvHcsaGvgRtGtlialDiavrlLeetkkvdvlaiieelRkdRmalvqhpeqyeflykavveyae

0039614 (Phosphotyrosine protein) phosphatases II 1251-1492 8.5e-67 221.0 In-house 58-285 (297) alignment
Range on Protein: 1251-1492
Range on HMM: 58-285/297.0
QLCRYKNIVPNMDTVVKIDPLFENnvkVENSDFINANWVRGFDG-RQSYIATQGPKPNTIDHFWRMIIQHEVPLIIMATNLVEGDKiKCHRYWALFDGik
 ..|||.|.|. .. ||. |. .    ...||.|||..| |.|   . .|||||| |.|...||||. .. |. |.| |.||| .. ||..||    |  
dknrykdilpydhsrvklkpedgv...dldsdYinAsyvdgydlltrkfIatqgPlpetvedFwrmvweqgvtvivmLtklvelgr.kcaqywpeegg..

gqekdpnllvTESGIRVTTEEVAKSRDFILRTFRLEWNDKEHFVKHLALNNWPDYGVPSSPRAVLRAIEVARDIRYRN-PGQPIVVHCSAGVGRTGILVA
          |  ...||. .| .  ....||.... |.....|.|.   .|||.|||.|.. .|...| .|... .. .| |..||||||||||| ..|
..........tygdftvtllkvehldgytvrtlevtnngesrtvthfqytgwpdhgvppslellleflelvrealaelpkggpvlVHCsaGvgRtGtfia

VDIGIDMLLAGRRVNLTSIVQHMREDRGGMLQTFPQYEFAFKAI
 .. ...|  ...|.. ..|...|| |.|. ||. ||.| ..|.
aylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydal

0045450 (Phosphotyrosine protein) phosphatases II 1251-1491 2.2e-66 220.0 In-house 57-299 (307) alignment
Range on Protein: 1251-1491
Range on HMM: 57-299/307.0
QLCRYKNIVPNMDTVVKIDPLFENnvkVENSDFINANWV--------RGFDGRQSYIATQGPKPNTIDHFWRMIIQHEVPLIIMATNLVEGDKIKCHRYW
 ..|||.|.|. .| ||. .| ..   .|.||.|||..|         |.|  . .||||||.|.|...||||. .. | .|.| |.||| ...||..||
dknrykdilpydhtRVklssldgs...ledsdYiNAsyvrvpllllldgydlkrkfIatqgPlpetvedFwrmlweqgvtvivmltelvelgrekcaqyw

ALFdGIKGQEKDpnllvtesgIRVTTEEVAKSRDFILRTFRLE---WNDKEHFVKHLALNNWPDYGVPSSPRAVLRAIEVARDIRYRN-PGQPIVVHCSA
 .  | . . ..         ..||. .. .  ....||....    ......|.|.   .|||.|||.|.  .|. || .|... .. .| |..|||||
Pde.geeltygn.........ftvtllseehldgytvrtlevtdldgtgesrtvthfhytgwpdhgvppsfeelldfieevrkaleelpkggpvlVHCsa

GVGRTGILVAVDIGIDMLLAGRR---VNLTSIVQHMREDRGGMLQTFPQYEFAFKA
|||||| ..| .. ...| ..     |.| ..|...|| |.|. |.. ||.|  .|
GvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyea

subfamily_PTPRD_pd Subfamily PTPRD 1253-1493 8.2e-65 214.5 In-house 52-278 (564) alignment
Range on Protein: 1253-1493
Range on HMM: 52-278/564.0
CRYKNIVPNMDTVVKIDPLfennVKVENSDFINANWVRGFDGRQSYIATQGPKPNTIDHFWRMIIQHEVPLIIMATNLVEGDKIKCHRYWAlfdgikgqE
 ||.|||.   . |.. ..     ..|.||.|||... |.. |..|||||||...||. ||||. ....  |.| |.|.| .| |||.||         |
NRyanivaYdhsRVvLskv....egdegsDYINAsfidgyrkrkayIAtqgPlaetiedFWRmvweqnsstiVmltkleEkgkvkchkYWP........e

KdpNlLVTESGIRVTTEEVAKSRDFILRTFRL--EWNDKEHFVKHLALNNWPDYGVPSSPRAVLRAIEVARDIRyRNPGQPIVVHCSAGVGRTGILVAVD
|  .   |  .. || ||  .  |...|||.|  . ... . |..    .||| ||| |....|. |.  |... ..  .||||||||||||||. ...|
k..g.tetygeltVtleeeeeladyeirtfklkkkkssesreVrqFhFtsWPdhgvpesatslLdlirkvraln.epdagPivVhCSaGVGRTGtfivid

IGIDMLLAGRRVNLTSIVQHMREDRGGMLQTFPQYEFAFKAIG
. .. . . . |.. ..|...|..|  | ||  || | ..|| 
amlerikeektvDiyqyvkalrkqRnamVqteeQYiFiheail

subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 1232-1497 1.4e-64 212.9 In-house 11-269 (274) alignment
Range on Protein: 1232-1497
Range on HMM: 11-269/274.0
FDALPLNL-GNLADLPkNAAQLCRYKNIVPNMDTVVKidpLFENNVKVENSDFINANWVRGFDGR-QSYIATQGPKPNTIDHFWRMIIQHEVPLIIMATN
|  ||||   .  |..  ...  |||.|.||  . |    | ..... |.|..||||...|.|.. . |.||||| |||.. ||||| |.||..|.| |.
flelPlnfdqeeldvf.gsqtknryktilPnensrvl...lesessededssyinanyikGydeeskayvatqGPlpntvadfWrmiyqeevqvivmltk

LVEGDKIKCHRYWAlfdgikgQEKDPNLLVTESGIRVTTEEVAKSRDFILRTFRLEWNDKEHFVKHLALNNWPDYGVPSSPRAVLRAIEVARDIRYRNPG
| | .. ||..|.        ...| ..  .  .. ...|.. .  |. .|.. |.   .|. |||    .|||  .| .....|. ..  .. | ..  
lkeaneqkCavyfP.......daedyeiserygdveikvekiverndysvrklvlkylerersvkhywytdWPdhksPddantlldlvleveesreeena

Q--PIVVHCSAGVGRTGILVAVDIGIDMLLAGRRVNLTSIVQHMREDRGGMLQTFPQYEFAFKAIGSFAR
.  |.|||||||.||||. .|..|..  | .   |.. .|| ..| |||||.||  |||. ..|.  ...
klapvvvhCsaGiGrtGcfiaisiavrqlreeivvdvlkivcnlrldrGGmvqtseqyelihralclylk

0043336 (Phosphotyrosine protein) phosphatases II 1250-1491 2.9e-64 212.6 In-house 46-272 (278) alignment
Range on Protein: 1250-1491
Range on HMM: 46-272/278.0
AQLCRYKNIVPNMDTVVKIDPlfenNVKVENSDFINANWVRGFDGRQSYIATQGPKPNTIDHFWRMIIQHEVPLIIMATNLVEGDKIKCHRYWAlfdgiK
 ...|||.|.|.  . ||...      ....||.|||..| |..  . .|||||| |.|...||||. .. |. |.| |.||| ...||..||      .
kdknrykdilpydhsrvklsl....lggdldsdYinAsyvdgynvprkfiatqgPlpetvedFwrmvwelgvttivmLtelvelgrvkcaqYwp.....g

---GQEKdpnllvtesgIRVTTEEVAKSRDFILRTFRLE--WNDKEHFVKHLALNNWPDYGVPSSPRAVLRAIEVARDIRYrNPGQPIVVHCSAGVGRTG
     ..          ..||. .. .  |...||....   ......| |.   .|||.|||.|.  .|. ....|...  ... |..|||||||||||
gsltygd..........ftvtllkeehlddytvrtlevtnlgdgesrtvthyhylgwpdhgvpeslsllldflkavreale.dsngpvlVHCsaGvgRTG

ILVAVDIGIDMLLAGRRVNLTSIVQHMREDRGGMLQTFPQYEFAFKA
 ..|... ...|  ...|.| ..|...|| |.|..||. ||.| ..|
tfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflyea

subfamily_PTPN12_pd Subfamily PTPN12 1251-1495 3.3e-64 211.5 In-house 42-276 (290) alignment
Range on Protein: 1251-1495
Range on HMM: 42-276/290.0
QLCRYKNIVPNMDTVVKIDPLFENNvkveNSDFINANWVRGFDGRQSYIATQGPKPNTIDHFWRMIIQHEVPLIIMATNLVEGDKIKCHRYWAlfdgikg
.  |||.|.|   . |..    |..    .||.||||...| .|...|||.||| |.|.| |||||....| ...|| ..|| .|.||.|||.       
kknrykDilPydksrvelskieeee....gsdYinanfikgvegkleyiaaqgPLpktlddfWrmiweknveivvmaCrevelgkkkCerYWp.......

QEKDPNLLVTESGIRVTTEEvAKSRDFILRTFRLEWNDKEHFVKHLALNNWPDYGVPSSPRAVLRAIEVARDIRYrNPGQPIVVHCSAGVGRTGILVAVD
.|.. .| . |  . ...|. | . ||..||...| ..... |. .  ..||| |||||.  .|. || .|...  .  .|.||||||||||||...|.|
eegeeelefgefevtleeek.avdddflirtLkveaqkesrkvyqfhYtaWPDhgvPssaksllelielvrelqe.sedaPlvvhCsaGvGrtGtiiaid

IGIDMLLAGRR---VNLTSIVQHMREDRGGMLQTFPQYEFAFKAIGSF
.  ..| |..    ... ..|...|..|  . ||  |||. .||. ..
yvrellkaekipeeldvfdlvlelrkqraalvqtkeqyelvykavael

subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 1249-1492 4e-63 208.1 In-house 41-272 (281) alignment
Range on Protein: 1249-1492
Range on HMM: 41-272/281.0
AAQLCRYKNIVPNMDTVVKIDPLFENNvkveNSDFINANWVRGFDGRQSYIATQGPKPNTIDHFWRMIIQHEVPLIIMATNLVEGDKIKCHRYWAlfDGI
  .  ||.|||    | ||. |  ||.    |.|.||||.| |..| . ||||||| |.....||.|.....| .|.| |. .|..|.||||||   |. 
nvlknrYsnivaYDatrvkvtpneenk....ntDYinanfvpgykgekeyiatqgPvPaslvafWqmvweqkvsaivmvtreieagklkChrYWP..ddn

KgqekdpnlLVTESGIRVTTEEVAKSRDFILRTFRLEWN-DKEHFVKHLALNNWPDYGVPSSPRAVLRAIEVARDIRYRNPGQPIVVHCSAGVGRTGILV
.         .. . ..|.... .... .| |.|.|| .  ..  |..||  .||| |||......|   .  . .. ..  .|.|.||||||||||  .
s........elkygdvtvkstaeeekatyierkfkleresgetreveqlaytaWPdhGvPattkellefrkevlkltekktkaplvihCsaGvGrtGtyi

AVDIGIDMLLAG-RRVNLTSIVQHMREDRGGMLQTFPQYEFAFKAI
|.|  .. . |  ...... .|...|..|  |.||  |||| .||.
alDrlvkaveaeleeldvkavvaelrkernlmvqtvvqyefvykav

Y_phosphatase Protein-tyrosine phosphatase 1252-1492 7.7e-63 207.4 Pfam-A 4-233 (235) alignment
Range on Protein: 1252-1492
Range on HMM: 4-233/235.0
LCRYKNIVPNMDTVVKIdplfenNVKVENSDFINANWVRGFDGRQSYIATQGPKPNTIDHFWRMIIQHEVPLIIMATNLVEGDKIKCHRYWAlfdgikgq
 .|||.|.|  .| ||.      . . ..||.||||.|.|..  ...|||||| ..||..||||..|..| .|.| |.|.| .. ||..||         
knRykdilpydktrvkl......kgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwp........

eKDPNLLVTESGIRVTTE-EVA-KSRDFILRTFRLEWNDKE---HFVKHLALNNWPDYGVPSSPRAVLRAIEVARDIRyRNPGQPIVVHCSAGVGRTGIL
 .. .  .|   |.|... ..  .. ...||...|. ...|   . ||.| ..||||.|||.||...|. |.  .  . ..  .|.||||||||||||..
.eeeeesltygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkveksk.eaksgpvvVhCsaGvgRtgtf

VAVDIGIDMLLAGRRVNLTSIVQHMREDRGGMLQTFPQYEFAFKAI
||.|| ...| |.. |.. .||...|. | || |.. ||.|  |||
valdilleqleaeeevdvlqivkelRkqRpgmvqsleqYiflykai

Y_phosphatase Protein-tyrosine phosphatase 1252-1492 7.7e-63 207.4 In-house 4-233 (235) alignment
Range on Protein: 1252-1492
Range on HMM: 4-233/235.0
LCRYKNIVPNMDTVVKIdplfenNVKVENSDFINANWVRGFDGRQSYIATQGPKPNTIDHFWRMIIQHEVPLIIMATNLVEGDKIKCHRYWAlfdgikgq
 .|||.|.|  .| ||.      . . ..||.||||.|.|..  ...|||||| ..||..||||..|..| .|.| |.|.| .. ||..||         
knRykdilpydktrvkl......kgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwp........

eKDPNLLVTESGIRVTTE-EVA-KSRDFILRTFRLEWNDKE---HFVKHLALNNWPDYGVPSSPRAVLRAIEVARDIRyRNPGQPIVVHCSAGVGRTGIL
 .. .  .|   |.|... ..  .. ...||...|. ...|   . ||.| ..||||.|||.||...|. |.  .  . ..  .|.||||||||||||..
.eeeeesltygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkveksk.eaksgpvvVhCsaGvgRtgtf

VAVDIGIDMLLAGRRVNLTSIVQHMREDRGGMLQTFPQYEFAFKAI
||.|| ...| |.. |.. .||...|. | || |.. ||.|  |||
valdilleqleaeeevdvlqivkelRkqRpgmvqsleqYiflykai

0045098 (Phosphotyrosine protein) phosphatases II 1251-1492 2e-62 206.4 In-house 35-268 (278) alignment
Range on Protein: 1251-1492
Range on HMM: 35-268/278.0
QLCRYKNIVPNMDTVVKidplfennvkvensDFINANWVRGFdgRQSYIATQGPKPNTIDHFWRMIIQHEVPLIIMATNLVEGDKIKCHRYWAlFDGIKG
 ..|||.|.|.  . ||              |.|||....|.  .. .||||||.|.|...||||. .. .. |.|.|.|||....||..||   .| . 
dknRykdilpydhsrVk..............dYINAsyidgy..pkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrekcaqywp.eggslt

QekdpnllvteSGIRVTTEEVAKSRDFILRTFRLE------WNDKEHFVKHLALNNWPDYGVPSSP--RAVLRAIEVARDIRY------------RNPGQ
            ...||....    |..|||....       ......|.|| . .|||.||||.|  . .|...|  |. .              ..| 
y..........gdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsgg

PIVVHCSAGVGRTGILVAVDIGIDMLlaGRRVNLTSIVQHMREDRGG-MLQTFPQYEFAFKAI
|..||||||||||| |||... ...|  ...|.| ..|...|. |.| ..|.. ||.| ....
pvlVHCsaGvgRtGtlvaaylmlell..eggvdlleavkelrsqRpglavqnleqyrflyefl

subfamily_PTPRB_pd Subfamily PTPRB 1243-1494 9.6e-62 203.6 In-house 46-283 (293) alignment
Range on Protein: 1243-1494
Range on HMM: 46-283/293.0
ADLPKNAAQlCRYKNIVPNMDTVVKIDPLFENnvkvENSDFINANWVRGFDGRQSYIATQGPKPNTIDHFWRMIIQHEVPLIIMATNLVEGDKIKCHRYW
|.|..|.|.  ||.||.|   . ||. .| ..    ..||.||||...|.  .. .|||||| |.|.|.||||. ....  |.| |.|||. |.||..||
aelavnrak.nrytnilpydhsrvkLaalkde....sgsDYinanyipgynsprefiatqGPlpetvddfWrmvwekkssiivmltqlvekgkvkCeeYW

ALFdgikgqekdpNLLVTESGIRVTTEEVAKSRDFILRTFRLEWNDKEHFVKHLALNNWPDYGVPSSPRAVLRAIEVARDIR-YRNPGQPIVVHCSAGVG
             .  |.   |.||  .  . .|...|....| ...|. |...    |||.|||......|. ..  |.     .  .|||||||||||
Pad..........eepvlyGdikvtlvaeeeledwvirelkiekekeerkvrqyhftsWpdhgvPektktlldfvrtvreaiektaskrPivvhCsaGvG

RTGILVAVDIGIDMLLAGRRVNLTSIVQHMREDRGGMLQTFPQYEFAFKAIGS
|||...|.|  .. .     |....||...||.|  ..||  || |  ... .
RtGtfialdrllqaieeedyvdifgivaelReeRnllvqtekqYifihqcvld

0040439 (Phosphotyrosine protein) phosphatases II 1251-1491 3.9e-61 202.1 In-house 13-241 (249) alignment
Range on Protein: 1251-1491
Range on HMM: 13-241/249.0
QLCRYKNIVPNMDTVVKIDPLFEnnvkVENSDFINANWVRGFDGRQSYIATQGPKPNTIDHFWRMIIQHEVPLIIMATNLVEGDKIKCHRYWALfDGIKG
 ..||..|.|.  . ||. .| .    .. ||.|||... |..  . .|||||| |.|...||||. .. .  |.|.|.||| ...||..|| | .| . 
dknrypdilpydhsrvklsilpg....lflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywpl.ggsle

QekdpnllvteSGIRVTTEEVAKSRDFILRTFRLE--WNDKEHFVKHLALNNWPDYGVPSSPRAVLRAIEVARDIRYRN-PGQPIVVHCSAGVGRTGILV
            ...||. .| .. |...||..|.   ..... |.|.   .|||.|||.|.  .|. || .|... .. .| |..|||||||||||...
y..........gdftvtllsvevkddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfi

AVDIGIDMLLAGRRVNLTSIVQHMREDRGGMLQTFPQYEFAFKA
| .. ...|   ..|.| ..|...|. |.|. |.. ||.|  .|
aaylmleqlekelgvdleeavkllrsqRpgavqnpeqyrflyea

0042113 (Phosphotyrosine protein) phosphatases II 1251-1491 6.6e-61 201.1 In-house 11-238 (245) alignment
Range on Protein: 1251-1491
Range on HMM: 11-238/245.0
QLCRYKNIVPNMDTVVKIDPLFEnnvkVENSDFINANWVRGFDGRQSYIATQGPKPNTIDHFWRMIIQHEVPLIIMATNLVEGDKIKCHRYWALfDGIKG
...||..|.|. .| ||. |  .     . ||.|||..| |..  . .|||||| |.|...||||. .. .  |.| |...| ...||..|| | .... 
dknrysdilpydhtrvklspdgg....dldsdyinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywpl.geslt

QEKdpnllvtesgIRVTTEEVAKSRDFILRTFRLE--WNDKEHFVKHLALNNWPDYGVPSSPRAVLRAIEVARDIRYRNPGQPIVVHCSAGVGRTGILVA
 ..          ..||. .. .  |...||....   .|....| |.   .|||.|||.... .|...| .|... .... |..||||||||||| ..|
ygd..........ftvtllseehlddytvrtlevtnlgddesrevihyhylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfia

VDIGIDMLLAGRRVNLTSIVQHMREDRGGMLQTFPQYEFAFKA
... ...| . ..|.| ..|...|. |.|. ||. ||.|  .|
aylmleqlekelgvsleeavkelrsqRpgavqtpsqyrflyea

0037934 (Phosphotyrosine protein) phosphatases II 1252-1491 4.8e-57 188.6 In-house 13-237 (243) alignment
Range on Protein: 1252-1491
Range on HMM: 13-237/243.0
LCRYKNIVPNMDTVVKIdplfennvkvENSDFINANWVRGFDgRqsYIATQGPKPNTIDH----FWRMIIQHEVPLIIMATNLVEGDKIKCHRYWAlfdg
 .||..|.|. .. ||.          |.||.||||...... |  .|||||| |.|...    ||||. .. .  |.| |.||| ...||..||     
knrysdilpydhsrvkl..........egsdyinanliyvtp.r..liatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywp....

ikgqekdP-NllvTESGIRVTTEEVAKSRDFILRTFRLEW---NDKEHFVKHLALNNWPDYGVPSSPRAVLRAIEVARDIRYR-------NPGQPIVVHC
             |  ...||. ..    |...||..||.   .| ...| |.   .|||.|||.||  .|. .. .|..  .       ..| |..|||
.......gev...tygdftvtllseehlddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHC

SAGVGRTGILVAVDIGIDMLlagrRVNLTSIVQHMREDRGG-MLQTFPQYEFAFKA
|||||||| |.| .. ...|    .|.| ..|...|| |.| . ||. ||.|  .|
saGvgRtGtliaaylmllll....gvdleeavkllreqRpgkavqtpsqyrflyea

subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 1253-1493 6.5e-56 184.7 In-house 50-277 (318) alignment
Range on Protein: 1253-1493
Range on HMM: 50-277/318.0
CRYKNIVPNMDTVVKIDPLfennVKVENSDFINANWVRGFDGRQSYIATQGPKPNTIDHFWRMIIQHEVPLIIMATNLVEGDKIKCHRYWAlfdgikgqE
 || ||..  .| ||...|    ...|.||.||||.. |.  ...|||.|.| |.||. ||||. . .  .|.| |...|  |.|.||||         .
nryanilaydhtrvkLqml....egeegsDyinanyidGyrrkkayiaaqaPlpetieDfWrmvWeqnsavivmltqeeergkakvhryWP........s

KDPNLLvteSGIRVTTEEVAKSRDFILRTFRLEWND--KEHFVKHLALNNWPDYGVPSSPRAVLRAIEVARDIRYRNPGQPIVVHCSAGVGRTGILVAVD
|... .     ..|. .|  .. |..||.|... ..  ..  |.     .||| |||.|.  .|  .  .. .  ..  .||||||||||||||. .|||
kgsrsy...gklvvelkeevelsdyvlrefkvtrteeeesrqvrqyhytsWpdegvpesgaslldlvrqvskaqqksgagpivvhCsaGvGrtGvfiavd

IGIDMLLAGRRVNLTSIVQHMREDRGGMLQTFPQYEFAFKAIG
| .. . |   |..  .|...|| |  | ||  |||| .... 
illerikaealvDvfqtvkqlreqrnlmvqtedqyefiydvll

subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 1249-1492 1.4e-54 180.3 In-house 46-279 (305) alignment
Range on Protein: 1249-1492
Range on HMM: 46-279/305.0
AAQLCRYKNIVPNMDTVVKIDPLFENNvkveNSDFINANWVRGFDGRQSYIATQGPKPNTIDHFWRMIIQHEVPLIIMATNLVEGDKIKCHRYWAlfdGI
 ..  |.|.|..  |  ... .  ...    .||.|||..| |......||..||| .||.. |||.|..  |  |.| |.||||.| ||..||.   . 
nkaknrlkeitlldddriiltekesld....dsdyinasyvdgykrkkkyivaqgPlkntvadfWrliveekvstivmltklveggkdkCrqYWp...es

KGQEKDpnLlvteSGIRVTTEEVAKSRDFILRTFRLEW---NDKEHFVKHLALNNWPDYGVPSSPRAVLRAIEVARDIRYRNPGQPIVVHCSAGVGRTGI
|...|.  .      . |. .. ..  |.| | ...     ..... | .. | .||| ||| .. ..|. |.  .  . .. |.|..|||||||||||.
ktekke..f....gefsvelksektasdyieRklkisiededkesrtvlqyqltdWPdhGvpqfatsllslikrvqkdqkkdkgvpllVhCsagvgRtGv

LVAVDIGIDMLLAGRRVNLTSIVQHMREDRGGMLQTFPQYEFAFKAI
 .|||| .. | .   |..  .....|. | .|.||  || | . |.
fiavdialerlkkEevvdvfevlkqlRskrmkmvqtldqYvflhdal

subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 1242-1492 2.6e-54 179.2 In-house 41-275 (288) alignment
Range on Protein: 1242-1492
Range on HMM: 41-275/288.0
LADLPKNAAQlCRYKNIVPNMDTVVKIDPLfennVKVENSDFINANWVRGFDGRQSYIATQGPKPNTIDHFWRMIIQHEVPLIIMATNLVEGDKIKCHRY
 . |..|| .  ||.||.|   . ||.. |     .....|.|||... | .... ||||||| ..|...||... ....  |.| |.||||.| ||..|
agrlavnakk.nRyrnilpyDekrvklkkl....eeeagaDYinasyidgekkkkkyiatqgPladtvndfWelvyenktstivmltelveggktkCeeY

WAlfdgikgQEKDPNLLvteSGIRVTTEEVAKSRDFILRTFRLEWNDKEHFVKHLALNNWPDYGVPSSPRAVLRAIEVARDIRYRNpGQPIVVHCSAGVG
|        ....|..      . ||  |. .  ||.||.. || . .|  .....   ||| ||| | . .|  ..        .  .||.||||||||
WP.......dadkpkny...GsvtvtlveskeledfvlrklllekkkteleitqyqylaWpdhgvPeskapllellrqvkvanqad.tgpiivhCsaGvG

RTGILVAVDIGIDMLLAGRRVNLTSIVQHMREDRGGMLQTFPQYEFAFKAI
|||. .|.|  ||.. .   ......|...|. |  . ||  |||| ....
rtgtFialdalidaveeedyiDvagtvaklRkqRallvqtlkqYefiyevl

subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 1243-1497 3.7e-53 175.7 In-house 43-284 (319) alignment
Range on Protein: 1243-1497
Range on HMM: 43-284/319.0
ADLPKNAAQlCRYKNIVPNMDTVVKIDPLFEnnvkVENSDFINANWVRGFDGRQSYIATQGPKPNTIDHFWRMIIQHEVPLIIMATNLVEGDKIKCHRYW
|. ..|  .  ||.||..   | |.. .| .    ||.||.|||... |.. |. .||||.|. |||. ||||. ..|.  ..| |.|||  |.|...||
askeenkkk.nryqnilaydrtrvvlseldg....vegsdyinasfidgyqerekfiatqaPlentiedfWrmvWeeessivvmltklveklkvklkkyw

AlfdgikgqEKDpnlLVTESGIRVTTEEVAKSRDFILRTFRLEWNDKEH---FVKHLALNNWPDYGVPSSPRAVLRAIEVARDIRYRNPGQPIVVHCSAG
         |..    ..   . || ||  .  |.| | . |. .  |     |||   ..||| .|| . ...|  ..  |  | ..  .|||||||||
p........een...feeyGrlivtleeeeeledyiirklklnkkssevetRevkhfqyteWpdhdvPekatslldllkrirksrektqsgPivvhCsaG

VGRTGILVAVDIGIDMLLAGRRVNLTSIVQHMREDRGGMLQTFPQYEFAFKAIGSFAR
|||||  ...|. .. .     ... |.|...|  |  | |.  ||.| ..|.  .. 
vGRtGtfivldamlervkeegvlDvfstvsrlRtqRnimvqrpeqYkfiyealleave

subfamily_Ptp69D_pd Subfamily Ptp69D 1252-1495 7.8e-53 174.6 In-house 51-285 (307) alignment
Range on Protein: 1252-1495
Range on HMM: 51-285/307.0
LCRYKNIVPNMDTVVKIDPLFENnvkvENSDFINANWVRGFDGRQSYIATQGPKPNTIDHFWRMIIQHEVPLIIMATNLVEGDKIKCHRYWALFdgikgQ
  ||..|..  .| ||. ..  .    |.||.|||....|.. ....|| |.|  .||. ||||| . || ||.| .|| | .. ||..||.       .
knRyedikafDktRvkLkkingk....edsdYinasfikgykekkkfiaaqdPveatigDfWRmiaeqevtlivmlsnlteknrkkcakYWpie.....d

----EkdpnllvtesGIRVTTEEVAKSRDFILRTFRLEWND-------KEHFVKHLALNNWPDYGVPSSPRAVLRAIEVARDIRYRNpGQPIVVHCSAGV
    .           | |.. .  |  |.| |.. .  ..       ... |     ..|.|. || ..|..|. || .|..   |   ||||||||||
evqyg..........dilvklvseekhsdyiiReldvskkkeesgevedsrkvvqyhytgWkDskvPevargllklieqvrelykln.rsPivvhCsaGv

GRTGILVAVDIGIDMLLAGRRVNLTSIVQHMREDRGGMLQTFPQYEFAFKAIGSF
||.||.||.|. .. | |  .|..  .|...|..|  ..| . ||.| ..|.  .
grsgifvaldsllqqlkaedkvdifetvkdLrsqRnllvqsleqYvflyralldy

subfamily_PTPRA_pd Subfamily PTPRA 1249-1500 4.2e-52 172.1 In-house 58-298 (330) alignment
Range on Protein: 1249-1500
Range on HMM: 58-298/330.0
AAQLCRYKNIVPNMDTVVKIDPLfennVKVENSDFINANWVRGFDGRQSYIATQGPKPNTIDHFWRMIIQHEVPLIIMATNLVEGDKIKCHRYWAlfdgI
  .  |. ||.|.  . | . ..      ||.||.||| .. |.  ....||.|||| .|.. ||||| ...   |.| |.| | .. ||..||      
nkeknrvvnilPydfsrvilsvk....eGveesdyinasfidGykekdkfiaaqGPkeetvedfwrmiweqksativmltelkerkeekcaqywP....d

KGqekdpnlLVTESGIRVTTEEVAKSRDFILRTFRLE------WNDKEHFVKHLALNNWPDYGVPSSPRAVLRAIEVARDIRYRNPGqPIVVHCSAGVGR
.|       |||   |||. |..  . |. .| | ..       ..|.  |. . .. ||| |||. |. .|. ..  . .. .. | ||||||||||||
eG.......lvtyGnirvevedetvlvdytvrkflvqqlpdatrekksrlvrqfhftswPdvGvPfepiGmlkllkkvkklnqqsag.pivvhcsaGvGr

TGILVAVDIGIDMLLAGRRVNLTSIVQHMREDRGGMLQTFPQYEFAFKAIGSFArLYG
|| ....|  .... | |.|..  .|...|  |  |.||  |||| .|..  .  |||
tGtfivldavlervkaerkvdvfefvkrlrlqrpqmvqtdeqyefiykvlleyy.lyg

subfamily_PTPN13_pd Subfamily PTPN13 1250-1492 4.6e-52 172.0 In-house 38-265 (273) alignment
Range on Protein: 1250-1492
Range on HMM: 38-265/273.0
AQLCRYKNIVPNMDTVVKIDplfennvkvENSDFINANWVRGFDG--RQSYIATQGPKPNTIDHFWRMIIQHEVPLIIMATNLVEGDKIKCHRYWAlfdg
 .  ||.|..|  .| ||..         ... .|||....   |  . .|||.||| |.|.. ||.|. . .. .|.| |. .|..|.||||||     
kdknryrnvlPydetrvklg.........deggyinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweqkaeviamvtlekekgkvkchrywP....

ikgQEKDPNlLVTESGIRVTTEEVAKSRDFILRTFRLEWND--KEHFVKHLALNNWPDYGVPSSPRAVLRAIEVARDIRYrnPGQPIVVHCSAGVGRTGI
   ..|. . |. .. ..|. ..| |  .| .|.. .. ..  . . | || . .|||.|||||.  .|. .   | ..      |||||||||.||.|.
...esknkk.lkvsnrlevellkvqkldgfvvralavkdsesgesrevahlnfvkwPdhgvPssaaellqfvaevrrlqt..dagPivvhcsaGiGrsGt

LVAVDIGIDMLLAGRRVNLTSIVQHMREDRGGMLQTFPQYEFAFKAI
|...|. ....   . .... ||...|| | |..||  || | .|||
litidvvlglierdkefdvkeivrklreqrqgvvqtkdqyifvykai

subfamily_PTPN9_pd Subfamily PTPN9 1253-1497 9.2e-52 170.9 In-house 46-291 (297) alignment
Range on Protein: 1253-1497
Range on HMM: 46-291/297.0
CRYKNIVPNMDTVVKIDPLFENnvkvENSDFINANWVRGFDGRQSYIATQGPKPNTIDHFWRMIIQHEVPLIIMATNLVEGDKIKCHRYWALFDGIKGQe
 ||....   .| |..  . |.    |.||.||||.| |.  ....|||||| ..|.. ||||. ..||  |.|.| .||  ..|| .|| | ..   . 
nrytdvlcydetrvvlakvded....easdyinanfvdGykqkkafiatqGplkktvsdfWrmvWeqevlvivmttrvvergrlkcgqyWpleeessae.

kdpnllvtESGIRVTTEEVAKSRDFILRTFRLE--WNDKEHFVKHLALNNWPDYGVPSSPRAVLRAIEVARDI------------RYRNPGQPIVVHCSA
         . ..|.. || ...|.  |.. ..   ....  | |  .  |||||||||  ..|  .|..|.             ...  | ||||||||
........fgdlsvsnveveeeedykvrvleiknvkteesrkvthfqflsWPdyGvPssaaslldvlekvrekqalavkelgdewkghpsgPPivvhcsa

GVGRTGILVAVDIGIDMLLAGRRVNLTSIVQHMREDRGGMLQTFPQYEFAFKAIGSFAR
|.|||| ....|| .. |     |...  |...|. |  ..||  |||| ..|.  .| 
GiGrtGtfitldiclsrleevgtvdvvetvkllrtqrafsiqtpeqyefcylavleyal

subfamily_PTPN6_pd Subfamily PTPN6 1253-1496 1.2e-51 170.6 In-house 58-297 (306) alignment
Range on Protein: 1253-1496
Range on HMM: 58-297/306.0
CRYKNIVPNMDTVVKIDplfenNVKVENSDFINANWVR--GFDGRQSYIATQGPKPNTIDHFWRMIIQHEVPLIIMATNLVEGDKIKCHRYWAlfdgikg
 |||||.|  .|.|..      . .| .||.|||| ..    . ..|||||||  ..|.  ||||. | .  .|.|.|. ||  | || |||        
nryknilPfDhtrvilk.....epsvpgsdyinanyikkevkgsdksyiatqgclettvsdFWrmvwqensrvivmttkevErgkekCarYWP.......

QEKDPNLlVTESGIRVTTEevAKSRDFILRTFRLE---WNDKEHFVKHLALNNWPDYGVPSSPRAVLRAIE-VARDIRYRN--PGQPIVVHCSAGVGRTG
.|.. .    .  .. ..|   . .|.|||.....    ...|. | ..  ..||| |||..| |||  .| | |  .. .     |||||||||.||||
deeekee.yGkisvtnvse..ksladYilRelsvskkkkkkeerevfqyhfksWPdhgvpkdpgavLdfledvnrkqeeleeaeagpivvhCsaGiGRtG

ILVAVDIGIDMLLA---GRRVNLTSIVQHMREDRGGMLQTFPQYEFAFKAIGSFA
 .. .|| ....        ... ..|. .|| | |..||  || | .|||  . 
tfiviDillkliekkgldadidiqklvksvreqrsglvqteqqykfvykaikkyi

subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 1245-1493 4.2e-51 169.0 In-house 53-287 (298) alignment
Range on Protein: 1245-1493
Range on HMM: 53-287/298.0
LPKNAAQlCRYKNIVPNMDTVVKidpLFENNvKVENSDFINANWVRGFDGRQSYIATQGPKPNTIDHFWRMIIQHEVPLIIMATNLVEGDKIKCHRYWAl
 |.|  .  || .|..   . |    | ... . |.||.||| .. ...||...||||.| ..|.  ||||......  |.| |||.| ||.|.|.||  
kpenkkk.NRyadiialdssRvv...Leked.adeesdYiNAsflhaykgrnafiatqaPltetvedFWrmvteedigtiVmltnleeldktkyhkywP.

fdgIKGQEKDPNLLVtesgirvTTEEVAKSRDFILRTFRLEWND--KEHFVKHLALNNWPDYGVPSSPRAVLRAIEVARDIRYRNPGQPIVVHCSAGVGR
    .|.|.  .. |       .  .  .  |.| |.. .. ..  ||. |..|   .||| |||.  ..||  ..  |  ....  .|..|.|||||||
...degketygeitv.......sllskeefadlivrklkvskkkeekerevrqlhftsWpdkgvpenatsvldllrkvrasqqqagnkpvivqCsaGvgR

TGILVAVDIGIDMLLAGRRVNLTSIVQHMREDRGGMLQTFPQYEFAFKAIG
.|  .|.|  .. . . . | .  .|. .|..| |..||  || | ..|. 
sGtfiaidsvlervkkeqvvDvfqvvkvlRkkrpgavqteeqYvfiyeavl

subfamily_PTPN3_pd Subfamily PTPN3 1242-1492 1.4e-50 166.8 In-house 35-271 (280) alignment
Range on Protein: 1242-1492
Range on HMM: 35-271/280.0
LADLPKNAAQlCRYKNIVPNMDTVVKIDplfENNvkveNsDFINANWV----RGFDGRQSYIATQGPKPNTIDHFWRMIIQHEVPLIIMATNLVEGDKIK
 | .|.|...  ||..|.|  .| ||..   |..    . |.||||.|     . .  . ||||||| ..|  .||.|. .... ||.| |.|||  ..|
aarkpenlsk.nryrdilpydatrvklk...ese....t.dyinanyvnmeipstglvnryiatqGPlaktatdfWqmvweqksslivmlttlverGrvk

CHRYWAlfdgikgQEKDpNLLVTesGIRVTTEEVAKSRDFILRTFRLEWND--KEHFVKHLALNNWPDYGVPSSPRAVLRAIEVARDIRYRNpGQPIVVH
||.||        ...| .|  .  ...|. |. .... ..|| . |. ..  .|. . .|   .||| |||...  .|. .|  |..|  .  .|.|||
ChqyWP.......eted.eleyg..efsvkcekedetksyvlrelvlkdketkeerkilqlqylaWpdhgvPddsadflefvervrklrsgk.eePvvvh

CSAGVGRTGILVAVDIGIDMLLAGRRVNLTSIVQHMREDRGGMLQTFPQYEFAFKAI
||||.||||.|..... . .. | . |.   ||..||. |. ..||  ||.|  .||
CsaGigrtGvlilletalalieaaepvypldivrtmrdqramlvqtasqykfvCeai

subfamily_PTPRG_pd Subfamily PTPRG 1253-1494 2.2e-49 163.1 In-house 51-285 (563) alignment
Range on Protein: 1253-1494
Range on HMM: 51-285/563.0
CRYKNIVPNMDTVVKIDPLFENNVKVensDFINANWVRGFDGRQSYIATQGPKPNTIDHFWRMIIQHEVPLIIMATNLVEGDKIKCHRYWALfdgiKGQE
 || |||.   . ||. || ... |    |.||||.. |.   . .|||||| ..|.| ||||| ...| .|.| |||||  . ||..||       . |
nRylnivaydrsRvklsplpgkkkkl...DYinAnyidGyqkskafiatqgplkdtfddFWrmiWeqnvaiivmitnlvergrrkcdvYWPk....dese

KDPNLLVTEsgIRVTTEEVAKSRDFILRTFRLEWNDK---EHFVKHLALNNWPDYGVPSSPRAVLRAIEVARDIRYRNPGqPIVVHCSAGVGRTGILVAV
.  .| ||   |.  .  .  .| .... ..|. ...   |. |..    .||| |||...  ||  .. .   . .. | ||||||||||||||.....
tygalqvtl..ieeevlalytvrtlviknlklkkkkqcdteklvrqyhytkWPdhgvPehslpvLifvkkssaankaeaG.PivvHcsaGvgrtGtyivl

DIGIDMLLAGRRVNLTSIVQHMREDRGGMLQTFPQYEFAFKAIGS
|  .  . .   ||.  ...|.|  |  ..||  || | ..|. .
dtllkqiqqenavnvfgflkhiraqRnflvqteEqYiflhdalle

subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 1241-1492 6.4e-49 162.0 In-house 54-287 (319) alignment
Range on Protein: 1241-1492
Range on HMM: 54-287/319.0
NLADLPKNAAQlCRYKNIVPNMDTVVKIDPLfennVKVENSDFINANWVRGFDGRQSYIATQGPKPNTIDHFWRMIIQHEVPLIIMATnlvegdKIKCHR
. |.|..|  .  |. ||..   .|||...|    . .| ||.||| .| |.  .. |||.|||..||.. ||||| ....  |.. |      | || .
tfanldqnkdk.nriinilafdknvvklerl....iGeefsdyinasfvtGyqrkdkyiaaqGPldntladfWrmiweyncstivllt......kdkcsq

YWALfdgiKGQEKdpnllvtESGIRVTTEEVAKSRDFILRTFRLEWNDKEH---FVKHLALNNWPDYGVPSSPRAVLRAIEVARDIRYR-NPGQPIVVHC
|| |    |...|       |    |  . | .. ....| ..|  . ||.    ..   .  |||.||| .|  ..| ..  | .. . |  ..|||||
ywpl....kivik.......eerfkvkvdsveetaeyvvrdielsedgkekdirkitqfhflGwpdvGvpdypsdlmrlvkkvrhltskenhranivvhc

SAGVGRTGILVAVDIGIDMLLAGRRVNLTSIVQHMREDRGGMLQTFPQYEFAFKAI
||||||||. ...|. .|..   ..|..  .|. .|..|  ..| . || | . |.
saGvGrtGvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysal

subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 1252-1493 1.3e-48 160.4 In-house 12-239 (250) alignment
Range on Protein: 1252-1493
Range on HMM: 12-239/250.0
LCRYKNIVPNMDTVVKidpLFENNvKVENSDFINANWVRGFDGRQSYIATQGPKPNTIDHFWRMIIQHEVPLIIMATNLVEGDKIkCHRYWALfdgiKGQ
  || .|..   . |    |....   ..||.||| .. |.|.|...|||||| ..|| .||||......  |.| |||.| .|  .|.||      .. 
knryadiialdssrvv...Lekek.gdkesdyinasflhgyderkafiatqgPlqatiedfWrmvleeksgtivmLtnLkesekt.yhqywPv....eka

EkdpnllvTESGIRVTTEEVAKSRDFILRTFRLEWNDKEHF--VKHLALNNWPDYGVPSSPRAVLRAIEVARDIRYRNPGQPIVVHCSAGVGRTGILVAV
|       .  ...|.  .  .  |.. |.. |  . |..   |..|   .||| |||   .|||  ..  .  . .   .|..|.|||||||.|  .|.
e.......kyGdvtvsllskeefadytkrklklskakkaderivrqlhfvvWPdkgvPevatavLellkkvqasqqqagnaPvivqCsaGvgrsGafiai

DIGIDMLLAGRRVNLTSIVQHMREDRGGMLQTFPQYEFAFKAIG
|  .. |   . |..  ... .|.|| .....  || | ...| 
davlerlkkekvvdvfkvikvlrkdrphavesleqyvfvyeiil

subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 1241-1492 2.5e-48 160.0 In-house 18-251 (284) alignment
Range on Protein: 1241-1492
Range on HMM: 18-251/284.0
NLADLPKNAAQlCRYKNIVPNMDTVVKIDPLfennVKVENSDFINANWVRGFDGRQSYIATQGPKPNTIDHFWRMIIQHEVPLIIMATnlvegdKIKCHR
. |.|..|  .  |. .|..   .|||...|    . .| ||.||| .. |.  .. |||||||..||.. ||||| ....  |.. |      | || .
tfanldqnkdk.nrighilafdknvvklerl....iGeefsdyinasfitGyqrkdkyiatqGPldntladfWrmiweyncstivllt......kdkcsq

YWALfdgiKGQEKdpnllvtESGIRVTTEEVAKSRDFILRTFRLEWNDKEH---FVKHLALNNWPDYGVPSSPRAVLRAIEVARDIRYR-NPGQPIVVHC
|| |    |...|       |   .|  . | .| ....| ..|  . ||.    ..   .  |||.||| .|  ..| ..  | .. . |  ..|||||
ywpl....kivik.......eerfkvkvdsveeseeyvvrdielsedgkekdirkirqfhflgwpdvgvpdypsdlmrlvkkvrhltskenhranivvhc

SAGVGRTGILVAVDIGIDMLLAGRRVNLTSIVQHMREDRGGMLQTFPQYEFAFKAI
||||||||. ...|. .|..   ..|..  .|. .|..|  ..| . || | . |.
sagvgrtgvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysal

subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 1253-1492 3e-48 159.5 In-house 55-280 (297) alignment
Range on Protein: 1253-1492
Range on HMM: 55-280/297.0
CRYKNIVPNMDTVVKIDPLFENnvkvENSDFINANWVRGFDGrqSYIATQGPKPNTIDHFWRMIIQHEVPLIIMATNLVEGDKiKCHRYWAlfdgikgqE
 |||||.|     ||.  . ..     .||..|| .|.|.     .|.|| |...|.. ||.|.....|  |.| ... |.|| || |||.        .
sRYkniLPydssRvkLaivndd....pdsDyvnasfvkgnkh..rlittqmPmkatvadfWamvldeqvstivmlnddnerdk.kcaryWs........d

kdpNLLVTESGIRVTTEEVAKSRDFILRTFRLEWND--KEHFVKHLALNNWPDYGVPS--SPRAVLRAIEVARDIRYRNPGQPIVVHCSAGVGRTGILVA
   .  .|   . |... |.. . || |.. .. ..  ....||     .|||  |.   | ...|  |.  |.    |   |..|||.|||||||.|..
...kgvttfGdvsvvllsvsereGfikrelevtkgkakarrvvkqyqfveWPdkaverkdsassllklisevrkdfsqnaegPllvhclaGvGrtgvllt

VDIGIDMLLAGRRVNLTSIVQHMREDRGGMLQTFPQYEFAFKAI
.|  .        |..  .|...|..|  ..||  ||.| ..|.
idsvvaeakrekevdifglvkklrqerpylvqtkeqykfvyvav

subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 1253-1492 8.5e-48 157.7 In-house 47-272 (515) alignment
Range on Protein: 1253-1492
Range on HMM: 47-272/515.0
CRYKNIVPNMDTVVKIDPLfENNvkvENSDFINANWVRGFDGRQSYIATQGPKPNTIDHFWRMIIQHEVPLIIMATNLVEGDKIKCHRYWAlfdgikgqe
 |||||.|   . ||.. . ..|    .||..||  ...||  ..|||.|||.. ..| |||...|..|  |.| |.| ||||||| .||          
nryknilPydsvrvklevi.ndn...PhsdyfnasyipsfdndkayiasqgPnkasvddfWrlvlqenvttiamvtklkegdkikcgkyWP.........

KDPNLLVTESGIRVTTEEVAKSRDFILRTFRLEWNDKEHFVKHLALNNWPDYGVPSSPRAVLRAIEVARDIRYRNPgQPIVVHCSAGVGRTGILVAVDIG
. |   |    |.| .  .    . | |....  .|. . |    ...||| |||   ...|. |   .  . .    |...||||||||||.....|  
dkpgdsvkfGsikvelvsleactggikrkltvlkgddsrtvtqfhfteWPdkGvpkhtssllklikevkadhgqyt.hpliihcsaGvGrtGvvisidsv

IDMLLAGRRVNLTSIVQHMREDRGGMLQTFPQYEFAFKAI
.     .| |..  .|. .|..|  ..||  || | . |.
vahakttrmvdvfnfvtnirqkrpylvqtqeqyafiygav

subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 1247-1491 7.4e-47 154.6 In-house 44-278 (290) alignment
Range on Protein: 1247-1491
Range on HMM: 44-278/290.0
KNAAQLCRYKNIVPNMDTVVKIDPLFENNvkVENSDFINANWVRGFDGRQSYIATQGPKPNTIDHFWRMIIQHEVPLIIMATNLVEGDKIKCHRYWAlfd
..  .| |..|||.. |  . . |. ...    . ..||| .. |.  ...||||||| .||. .||..| |..|. |.| || .| .| ||. ||.   
ssnkllnRfanivvyddnritLrpisghk..DCtneyinAcyikgykekkqyiatqgpvsntlvdFWkliwqekvtiivmltniieegkvkCqqYWp...

gikgqEKDPNLlVTESGIRVTTEEVAKsrDFILRTFRLEWNDK---EHFVKHLALNNWPDYGVPSSPRAVLRAIEVARDIRYRNPGQPIVVHCSAGVGRT
     ..| .  . |  |... ||. .  ..| |..... ...   .. |... . ||.. |    | ..| .||   ......  ..||||||..|||.
.....dsdtka.ygefsikllneetln..eyierklevknknsagakqsvtqyqitnwdstgkvtnpqtillvieemyktqrkrgntsivvHCSdtvgrs

GILVAVDIGIDMLLAGRRVNLTSIVQHMREDRGGMLQTFPQYEFAFKA
....|....|.       ... ......|  . |..||  ||.. |. 
avfcaaattinkcktegvidvfqvlksqRiqkpgsvqtvqqyqgifqi

subfamily_PTPRK_pd Subfamily PTPRK 1253-1492 4.1e-46 152.2 In-house 47-273 (314) alignment
Range on Protein: 1253-1492
Range on HMM: 47-273/314.0
CRYKNIVPNMDTVVKIDPLFENnvkvENSDFINANWVRGFDGRQSYIATQGPKPNTIDHFWRMIIQHEVPLIIMATNLVEGDKIKCHRYWalfdgikgqe
 |...|..   . |.. .. ..     .||.|||... ..   . .|.||||...|.  |||.. ...   |.| |.|||  ..|| .||          
nrsgdilaydrsrvflitidgd....pssdyinaalidsykrpaafivtqgPlqetvkdfWrlvydencasivmltelvevgrvkClkyW..........

kdPNLLVTESGIRVTTEEVAKSRDFILRTFRLEW----NDKEHFVKHLALNNWPDYGVPSSPRAVLRAIEVARDIRYRNPGqPIVVHCSAGVGRTGILVA
  |.   .   |.|.  |.    ... |.||.|      .. . |...   .|||..|| | ...|. .      .  . | .|||||||| ||||. .|
..PedtevygdikvelvetellaelvvrifrveklargqeeirevrqfqflgWpdhdvPvsatgllklvrrvkksqeeeaG.rivvhCsaGaGrtGtfia

VDIGIDMLLAGRRVNLTSIVQHMREDRGGMLQTFPQYEFAFKAI
.|| .||.   . |..  .|. .|. .  |..|  || | . .|
idivldmieregvvdvfnavktlrsrkvnmveteeqykfiydvi

subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 1252-1493 3.1e-45 149.4 In-house 47-274 (315) alignment
Range on Protein: 1252-1493
Range on HMM: 47-274/315.0
LCRYKNIVPNMDTVVKIDPLfENNvkvENSDFINANWVRGFDGRQSYIATQGPKPNTIDHFWRMIIQHEVPLIIMATNLVEGDKIKCHRYWAlfdgikGQ
  |||||.|   . ||.. . ...    .||.|||  ....|  ..|||.|||.. ..| ||||..|..|  |.| |.. ||||||| .||        .
knryknilPldsarvklevi.dds...PdsdyinasyiksvdddkayiasqgPlkasvddfwrmvlqekvttivmvtkkqegdkikcrqywP......dr

EKDpnlLVTESGIRVTTEEVAKSRDFILRTFRLEWNDKEHFVKHLALNNWPDYGVPSSPRAVLRAIEVARDIrYRNPGQPIVVHCSAGVGRTGILVAVDI
. |   .|    |.|.. ..    | . | . .   .. . |    ...||| ||.    ..|. |   .    ..   ...|||||||||||.....| 
kad...svefGsikvellsleadtdgvarklvtrkseesrtvtqfqftewPdkGvdkqtssllklikevkad.ngkkefsllvhcsaGvGrtGvviside

GIDMLLAGRRVNLTSIVQHMREDRGGMLQTFPQYEFAFKAIG
 .. .  .| |..  .|. .|..|  ..||  .| | . |. 
vvaqikrtrsvdvfnfvknlrakrpylvqteeeyafiydavl

subfamily_PTPN23_pd Subfamily PTPN23 1253-1497 7.5e-44 144.7 In-house 47-281 (288) alignment
Range on Protein: 1253-1497
Range on HMM: 47-281/288.0
CRYKNIVPNMDTVVKIDplfennvkVENSDFINANWVRGFD-GRQSYIATQGPKPNTIDHFWRMIIQHEVPLIIMATNLVEGDKIKCHRYWALFDGIKGQ
 |...|.|   . ||..         .. |.||| .|..   |  ..||||.|...|.  ||.|. .  ...|.| ..  | .| |..|||    |   .
nrsrdilPyDhnRvklr........gskDDYinAsfvkdlspgcPdfiatqaPlqstlnDFWlmvyeqkssviVmllskeelgkpkvdrYwPedkgetvk

EKDpnllvtesgIRVTTEEVAKSRDFILRTFRLEWNDKEH--FVKHLALNNWPDYGVPSSPRAVLRAIEVARD---IRYRNPGQPIVVHCSAGVGRTGIL
 .|         ..|| ..| ..  .. |...|| .|...   |.|| |..||..|||.||  .|. ......    . |.  .|.||||||||||||..
fgd.........lsvtlksvretethvervlkletldadavksvshlqltsWpelGvPasPetllqfldevesayeavqrksktPlvvhCsaGvgRtgvf

VAVDIGIDMLLAGRRV-NLTSIVQHMREDRGGMLQTFPQYEFAFKAIGSFAR
  |   .  | .|  . ..  .|...||.|  |.|.  |..|...|.   ||
alvyaavrelekgnglldiiqvvsrlreqRrfmvqekeqlkfsyeavleaar

subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 1250-1492 1.1e-43 144.4 In-house 50-275 (315) alignment
Range on Protein: 1250-1492
Range on HMM: 50-275/315.0
AQLCRYKNIVPNMDTVVKIdPLFENNvkvENSDFINANWVRGFDGRQSYIATQGPKPNTIDHFWRMIIQHEVPLIIMATNLVEGDKIKCHRYWAlfDGik
 |  || ||..   . |.. || ||.   ..||..|||.. |.. .. |||.|||...... |||.. ....  |.| ||||||.| |. .||   |   
kqknryiniiaydksrvql.pllend...phsdyvnanfidGynkkrryiaaqgpnvasvkdfwrlvfeedigkivmltnlvegekrkaekywp..dk..

gqekdpnlLVTESGIRVTTEEVAKSRDFILRTFRLEWNDKEHFVKHLALNNWPDYGVPSSPRAVLRAIEVARDIRYRNPgQPIVVHCSAGVGRTGILVAV
         |.   | ||  .  .  ..  ||.    .|. . |  | .  ||| ||| .  ...  |  ..  .  .   .||||||||||||| ....
........kviyGkitvtrkseevnteytvrtlsvvfgdnirevvqlhytswpdmgvpkytiplmnlirtvkqhhtnsv.gaivvhcsaGvGrtGtfitl

DIGIDMLLAGRRVNLTSIVQHMREDRGGMLQTFPQYEFAFKAI
|  .| . | . ...  ... .|. | .|.|.  ||.| ..|.
davldqaeaenaidvynfitgvrqnrikmvqvaeqyqfiydal

subfamily_PTPN1_pd Subfamily PTPN1 1243-1492 1.3e-43 143.8 In-house 27-267 (290) alignment
Range on Protein: 1243-1492
Range on HMM: 27-267/290.0
ADLPKNAaQLCRYKNIVPNMDTVVKIDplfennvkVENSDFINANWVRGFDGRQSYIATQGPKPNTIDHFWRMIIQHEVPLIIMATNLVEGDKIKCHRYW
|.||.|  .| ||... |   . .|..         .. |.|||. |   . ..||| |||| |||.||||.|. ...   ..|  ..|| ..|||..||
aklpenr.nlnryrdvspydhsrikle........radndyinaslveleeakrsyiltqGPlpntvdhfWqmvWeqkskavvmlnkvvekeqikcaqyw

ALFDGikgqekDPNLLVTESGIRVTTEEVAKSRDFILRTFRLEW--NDKEHFVKHLALNNWPDYGVPSSPRAVLRAIEVARDIRYRNP-GQPIVVHCSAG
   .       . .||. .. ..|.  .  ... ...|...||    .. . . |     |||.|||.|| | |. .   |.    ..   | |.|||||
Pqgee......ekellledtklkvkliseerksyytvrllelenlktqetreilhfhyttwpdfgvpespaaflkflfkvresGslssdvGpavihcsaG

VGRTGILVAVDIGIDMLLAGR---RVNLTSIVQHMREDRGGMLQTFPQYEFAFKAI
.||.| .. ||  .  . .      |..   . ..|. | |..||  | .|.. ||
iGrsGtfclvdtclvliekkddlssvdikkvllelrkyrlGliqtadqlrfsylai

subfamily_PTPN14_pd Subfamily PTPN14 1242-1493 1.8e-43 143.6 In-house 43-293 (300) alignment
Range on Protein: 1242-1493
Range on HMM: 43-293/300.0
LADLPKNAAQlCRYKNIVPNMDTVVKIDPLFENnvkveNSDFINANWVRGFDG--RQSYIATQGPKPNTIDHFWRMIIQHEVPLIIMATNLVEGDKIKCH
 | ||.|| .  |.|...|  |. |.. |  ||     ....|||  ..   |  ..|||..||| ..|.  ||.|. ...| ||.| |.  |. | |..
taklpenaek.nrfkdvlPyednrvelsptken.....stgyinassikvsvggkersyivaqgPleltvqdfWqmvWeqgvqlivmlteeeedgkeksf

RYWAlfdgiKGQEKDPNllVTESGIRVTTEEVAKSRDFILRTFRLEW--NDKEHFVKHLALNNWPDYGVPSSPRAVLRAIEVARDIRYR--------NPG
.|.      | ..|  .  |.    .|||. . .|  .| ....|..    .|  | ||  ..||| |||. ..  |  .|  . .|..        .  
kyfP.....kleskkkt..vefgkfkvttkfsedsdsvittglklkhlpskeertvwhlqytDWpdhgvPeDvkgflsyLeevqsvrrktnseveskesk

QPIVVHCSAGVGRTGILVAVDIGIDMLLAGRRVNLTSIVQHMREDRGGMLQTFPQYEFAFKAIG
 |..|||||||||||.|. .|. |  |  ...... ......|| |  ..||. ||.| .|.. 
PPvlvhCsaGvGrtGvlilsdlliatlehneeidikkvlarLreqrmllvqtlaqYkfvYkvli

subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 1249-1496 1.1e-42 140.7 In-house 38-277 (287) alignment
Range on Protein: 1249-1496
Range on HMM: 38-277/287.0
AAQLCRYKNIVPNMDTVVKIdplfENNvKVENSDFINANWVRGFDGRQSYIATQGPKPNTIDHFWRMIIQHEVPLIIMATNLVEGDKIKCHRYWAlfdgi
|..  || ...|  || | .     ..     ||.||||.| ..   ...||.||| . |.  |||.......  .|. |  ||  . ||..||      
avkknryadvlPiddtrvll....sae.gelGsdyinanyvasytddeafiaaqgPiaatvrdfwravletrsasvitmtreveearlkcykywP.....

kgqEKDPNLLVTesGIRVT-TEEVAKSRDFILRTFRLEW-NDKE-HFVKHLALNNWPDYGVPSS----PRAVLRA---IEVARDiryRNPGQPIVVHCSA
   |..  ..|   |  |.  .   |. ..  |..||   . .| . || | | .||| ... .     | ||     ||.|||    .   |.|||...
...erevPmrvG..GysvvlldydikePeygvralrlidletrearvvkqldllswPdkvlaPtavglirfvldvkqhielard...asevGPlvvhddv

GVGRTGILVAVDIGIDMLLAGRRVNLTSIVQHMREDRGGMLQTFPQYEFAFKAIGSFA
|.||.|||.|. . ...|.   ||. . .| ..|| | ...|.  |. . ..|. .. 
GiGrsGillatlvlvsrledlGrvdvaavvirlreyraalvqavvqlrllyealvtyy

subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 1250-1492 5.9e-42 138.6 In-house 48-274 (287) alignment
Range on Protein: 1250-1492
Range on HMM: 48-274/287.0
AQLCRYKNIVPNMDTVVKIDplfennvkVENSDFINANWVRGFDGRQSYIATQGPKPNTIDHFWRMIIQHEVPLIIMATNLVEGDKIKCHRYWAlfdgik
 .. |...|..  .  | .          |. |.||| .. |.  .. .|....|  ||.  ||..| ...|. |.| ... | |. .|..||.      
kdknRltqilvpdnyrvllk........gehpdyinavfidgykekkafiiaesPmfntarnfWkliddrnvtaivmlcqekendeevcyqyWp......

gqE-KDpnLLVTESGIRVTTEEvaKSRDFILRTFRLEWND---KEHFVKHLALNNWPDYGVPSSPRAVLRAIEVARDIRYRNPGQPIVVHCSAGVGRTGI
  | |   ... |  |... ||  .. ..| |..... ..   ... ||   . ||.. |  ..|...|  ||     ....   .||||||..|||...
..eeks..vvlGeyniellnee..vnagyierklevknknkagdkqqvkqyqitnWdstgkvtepqtillvieemyktqrkrgntsivvhCsdtvGrsam

LVAVDIGIDMLLAGRRVNLTSIVQHMREDRGGMLQTFPQYEFAFKAI
..|....|.       ... ......|  . |..||  ||.| ....
fcaaattinkckteGviDvfqvlksqriqkpgsvqtveqykfindiv

subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 1249-1496 7.1e-41 134.8 In-house 40-293 (301) alignment
Range on Protein: 1249-1496
Range on HMM: 40-293/301.0
AAQLCRYKNIVPNMDTVVKIDPlfENNVKVENSDFINANWVRGFDGRQSYIATQGPKPNTIDHFWRMIIQHEVPLIIMATNLVEGDKIKCHRYWALFDGI
 ..| |.|||..  |  . . |  ..|... . ..|||... |.  .. .||.|||  .|.  |||.|.|. .  |.| ||| || | ||..||   .  
nkalnrfknitvyddnriilkp..kpnldlcqreyinasyidgysekkkfiaaqgpmkktlvdfWrliwqekpvsivmvtnlkegtkskceqywpnseae

KGQEKDPNLLVTESG------IRVTTEEVAKSRD--FILRTFRLEWNDKEHFVKHLALNNWPDYGVPSSPRAVLRAIEVARDIRYRNPGQPIVVHCSAGV
. ..   . .....       ||  .  . .. .  .| |.|. . . . . |  | . .||. ||   || ||..|.     . .  | |.|||||..|
seefgpftvtlvneqvyPdfvirqlnvkiqdgsnngyierkfkvksdksswdvlqlqvtdWpqdGvvreprtvLqviddvihrqqkigggpvvVHCSdtV

GRTGILVAVDIGIDMLLAGRRVNLTSIVQHMREDRGGMLQTFPQYEFAFKAIGSFA
.|.|. ..|.||..   |   |..  ... .|  . |. .|  || . ...|  . 
srsGvYcsvsiglEQckaegVVdvfqvtkavrrskpgaVtTLeqytsiydvidmyl

subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 1279-1491 1.9e-40 133.8 In-house 65-272 (307) alignment
Range on Protein: 1279-1491
Range on HMM: 65-272/307.0
ENSDFINANWVRGFDGRQSYIATQGPKPNTIDHFWRMIIQHEVPLIIMATNLVEGDKIKCHRYWALFDGIKGQEKDPNLLVTESGirVTTEEVAKSRDFI
  ||.| ||..      . .|..|||. ||. .|| |.||..|  .||  ...|  ||||..|| | .| |    . .  .. .   . ....|   |.|
lasdyihanylgiaikpkkficaqgplentqysfwamaiqekvesvimlckvielakikceqywpleegqklvfgeapntisvan..lgakklapdedli

-LRTFRLEWNDKEHFVKHLALNNWPDYGVPSsprAVLRAIEVARDIRYRNpgQPIVVHCSAGVGRTGILVAVDIGIDMLLAGRRV-NLTSIVQHMREDRG
 . |....| .|   ..||  .|||| |||      | ||..   .|| .   |.||||||||||.| .||. .  | ..||    ..  .|. .|..| 
nvttlkvdwaqksrtiqhlqwenwpdrgvpq...inltainlleavrydt..npvvvhcsaGvGrsGtivaislvqdkmiaGinckdmkklveelrsqrh

GMLQTFPQYEFAFKA
  .||  || .  . 
yaiqteaqylylhrv

subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 1242-1492 2.3e-40 133.7 In-house 42-284 (325) alignment
Range on Protein: 1242-1492
Range on HMM: 42-284/325.0
LADLPKNAAQlCRYKNIVPnMDtvvKIDPLFENNVKVENSDFINANWVRGFDGRQSYIATQGPKPNTIDHFWRMIIQHEVPLIIMaTNLVEGDKIKCHRY
 | .|.| |.  |.||.|. .|   |  . .|   .  .||.|||...| . ... ..|.| |...||. .||.... . ..... .| ....| .|  |
vamkpenkak.nrfknvva.ld...ksrvvletkkddpssdyinasylrddkkkdvflaaqaPltatindlWrlvldWrcsvvvv.lneldlgkdrcavy

WAlfdgiK--GQEkdpnllVTESGIRVTTEEVAKSRDFILRTFRLEWNDKE--HFVKHLALNNWPDYGVPSSPRAVLRAIEVARD----IRY-RNPGQPI
|      |  |.       .|  |..|    . .  |.. | . .   .|     || . |  |.| ||.  | ...  ...       ..   .   ||
wp.....kemgks......ktfGglevklrtieeisdyvhrvldvkqvkkGetrsvkqfqlqswddmGvqkrpatlisilqlvkavservtantkastpi

VVHCSAGVGRTGILVAVDIGIDMLLAGRRVNLTSIVQHMREDRGGMLQTFPQYEFAFKAI
.|||||||||||.....   .. ..   ||..   |...|.||  |..|  || . ..|.
lvhcsaGvGrtGvfislysalakvieesrvdifgfvkklrkdrpsmvetvdqyiliyeal

0041856 (Phosphotyrosine protein) phosphatases II 1253-1491 1e-39 131.3 In-house 5-166 (182) alignment
Range on Protein: 1253-1491
Range on HMM: 5-166/182.0
CRYKNIVPNMDTVvkidplfennvkveNSDFINANWVRGFDGRQSYIATQGPKPNTIDHFWRMIIQHEVPLIIMATnlvegdkikCHRYWAlfdgikgqe
 ||..|.|.  .               ..|.||||...|    . .|||||| ..|. .|.||. .. . .|...|         ...||.         
nrysdilpydhsr..............dldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt.........eelywp.........

kdpnllvtesgirvtteevaksrdfilrtfrlewNDKEHFVKHLALNNWPDYGVPSsPRAVLRAIEVARDiryrnPGQPIVVHCSAGVGRTGILVAVDIG
                                  .. |. . ..   .|||.|||. .. .|. || ...     .| |..||||||||||| ||| .. 
..................................ellerlgiqylylpwpDhgvpd.ldelldfieevle.....eggpvlVHCsaGvgRtgtlvaaylm

IDMllagrRVNLTSIVQHMREDRGGMLQTFPQYEFAFKA
. .     .|.|...|...|. | || .|  || |   |
kkl.....gvsleeavklvrsrRpgmvitpnqyfflqla

0051429 (Phosphotyrosine protein) phosphatases II 1279-1495 2.4e-39 131.0 In-house 2-224 (272) alignment
Range on Protein: 1279-1495
Range on HMM: 2-224/272.0
ENSDFINANWVRGFdGR----QSYIATQGPKPNTIDHFWRMiIQHEVPLIIMATNLVEGDKIKCHRYWalfdgikgqE----------KDPNLLVTESGI
. |. |||..| |. ||      .....|| |.|...|||.  .. .  |.. ....| .. ||.|||         .           |    ..   .
plsgyiNardvggy.grvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdryw.........pgirylhlpilddsaptilygal

RVTTEEVAKSRDFILRTFRLE---WNDKEHFVKHLALNNWPDYGVPSSPraVLRAIEVARDiryrnpGQPIVVHCSAGVGRTGILVAVDIGIDMLLAGRR
|||. ..    |.|||...|.    ... . | ||   .|||.|||...  .|...|. .|      |.|..||||||..|||..||... .  . .   
rvtllseellldyilrellltlllsagearevmhlhytdwpdhgvpqea..llellellld......ggpvlvHCsaGkdRTGtvvallllllgvsleti

VN--------LTSIVQHMREDRGGMLQTFPQYEFAFKAIGSF
|.        |  .|...|. | |. ||  ||.| ..|.  .
vddYlltnlyleeaveelraqrpgavqteeqylflyeallel

0043147 (Phosphotyrosine protein) phosphatases II 1279-1488 3.5e-39 129.6 In-house 3-153 (172) alignment
Range on Protein: 1279-1488
Range on HMM: 3-153/172.0
ENSDFINANWVRGFDGRQSYIATQGPKPNTIDHFWRMIIQHEVPLIIMATNLvegdkikchrywalfdgikgqekdpnllvtesgirvtteevaksrdfi
|.||.|||... .    ...|||||| .||...||||. .. . .|...|.|                                                
egsdyinasyldlyyipdrfiatqgplrntladfwrmlkelgithivnltel................................................

lrtfRLEWNDKEHFVKHLALNNWPDYGVPsSPRAVLRAIEVARDIRYRNPGQPIVVHCSAGVGRTGILVAVDIGIdmllagRRVNLTSIVQHMREDRGGM
     . . . |... ..   .|||.||| ... .|...|  ...  ..|| |..||||||||||| ||| .. .      ....|  .|...|| |.|.
....lydpellerlgiqylylpwpDhgvp.llellleflefidellalspggpvlVHCsaGvgRtgtlvaaylml......lglsleeavalvrekRpga

LQTFPQYEFA
 |.. || | 
vqnpsqyrfl

subfamily_PTPRN_pd Subfamily PTPRN 1248-1492 2.2e-38 126.7 In-house 55-288 (297) alignment
Range on Protein: 1248-1492
Range on HMM: 55-288/297.0
NAAQLCRYKNIVPNMDTVVKIDplfeNNVKVENSDFINANWVRGFDGRQ-SYIATQGPKPNTIDHFWRMIIQHEVPLIIMATNLVEGDKIKCHRYWAlfd
....  |.|...|  .. ||..    .. . |.||.|||  .   | |. .||||||| ..|. .||.|. .. | .|.. |.| | .  .|.|||    
knvkknrskavlpydhsrvklk....eeasaeksdyinasaildhdprapayiatqgplastvadfwqmvweqGvvvivnltrleeegvkqckrywp...

gIKGQEkdpnlLVTESGIRVTTEEVaKSRDFILRTFRLEW--NDKEHFVKHLALNNWPDYGVPSSPRAVLRAIEvARDIRYRNPGQPIVVHCSAGVGRTG
  .|.|     .     ... .| .  . |...|.| |    ...   |  .    ||. |||.|....|       .  ||    |||||||.|.||||
.deGse.....vyhiyevhlvsehi.wcddylvrsfylknlqtsetrtvtqfhflswpeegvPasaksllefrr.kvnksyrGrscpivvhcsdGaGrtG

ILVAVDIGIDMLLAG-RRVNLTSIVQHMREDRGGMLQTFPQYEFAFKAI
. ...|. .. || | ....... ..|.|..| |...|  |.|||..|.
vyilidlvlnrllkGvkeidiaatlehlrdqrpglvktkdqfefaltav

subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 1252-1492 2.7e-38 126.3 In-house 59-279 (290) alignment
Range on Protein: 1252-1492
Range on HMM: 59-279/290.0
LCRYKNIVPNMDTVVKIDplfennvKVENSDFINANWVRGFDgrQSYIATQGPKPNTIDHFWRMIIQHEVPLIIMATNLVEGDKIKCHRYWAlfdGIKGQ
  |||..| |  | | ..          . |.. ||.|.| .    .| |||.  .|.  .|||..|..|  |.|  .|.|  | ||..|.      .|.
knrykdvvcndktrvilk.......dGydGdyvhanyvkGlk..amfiltqGalkdtvidiwrmvlqekvaaivmlceliedGkakceqyyp...ekeGe

ekdpNLLVTESGIrVTTEEVAKSRDFILRTFRL--EWNDKEHFVKHLALNNWPDYGVPSSPRAVLRAIEVARDIryrnPGqPIVVHCSAGVGRTGILVAV
     |   |  . . .||  |  . |..|. .    . ||| .||| .  |||  |. |  |.|| . . | .    .| |.|||||||.|||| .||.
....vltfGeitv.lcseeddkdaniikktlsvrdkdsGkehklkhlkikswpdksvalstlallrtlrilrka....sG.pvvvhcsaGiGrtGtfvai

DIGIDMLLAGRRVNLTSIVQHMREDRGGMLQTFPQYEFAFKAI
..|...|| |. ..|  .|. .|. | . .|   ||    ...
evglqilldGkeldlldlvralrnsrlnsvqvdiqylalveil

0036282 (Phosphotyrosine protein) phosphatases II 1281-1488 5.1e-37 122.6 In-house 2-162 (174) alignment
Range on Protein: 1281-1488
Range on HMM: 2-162/174.0
SDFINANWVRGFDGRQSYIATQGPKPntidhFWRMIIQHEVPLIIMATNLVEGDKIKCHRYWALfdgikgqekdpnllvtesgirvtteevaksrdfilr
||.|||... ..     .||.||| .     ||.|. .. .  ..| ....| .. ||..||                                      
sdyinaspldlsyitprliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe....................................

tfrlEWNDKEHFVKHLALNNWPDYGVPSSPRaVLRAIEVARDIRYRNPGQPIVVHCSAGVGRTGILVAVDIGIDMLLaGRRVNLTSIVQHMREDRGGMLQ
     ..| |... ..   .|||.|||...  .|.... ..... ..|| |..|||||||||||.||| .. . .||  . |.  ..|. .|  |.|| |
....lredlerlgiqylylpwpDhgvpdlsi.llefvkfveealsedpggpvlVHCsaGvgRtGtlvaaylmlrgll.eslvdaldlvrelRlqrpgmvq

TFPQYEFA
|. ||.| 
tpsQyrfl

0046846 (Phosphotyrosine protein) phosphatases II 1277-1490 5.7e-37 122.5 In-house 8-167 (176) alignment
Range on Protein: 1277-1490
Range on HMM: 8-167/176.0
KVENSDFINANWVRGFDgrqsYIATQGPKPNTIDHFWRMIIQHEVPLIIMATNLVEGDKIKCHRYWALFDGIKGqekdpnllvtesgirvtteevaksrd
  ...|.||||.. |      .|||||| |.|. .|..|. .. . .... |..|| ...||..|| .. . .                           
ldldldyinanlilgsr....piatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgi..........................

filrtfrlewndkehfvkHLALNNWPDYGVPSSpRAVLRAIEVARDIRYRNpgQPIVVHCSAGVGRTGILVAVDigidMLLAGRRVNLTSIVQHMREDRG
                  .    .|||.|||.. ...|...|  |. . ..  .|..||||||.|||| ||| .    .|  .. ...  .....|| | 
..................qylhlpwpDhgvpdl.elllellefirealkeg..gpvlVHCsaGigRtgtlvaay....llelekglsveealalvreqRp

-GMLQTFPQYEFAFK
 |..||. ||.|  .
lgavqtpeQyrflye

subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 1253-1491 2.3e-36 120.1 In-house 11-235 (239) alignment
Range on Protein: 1253-1491
Range on HMM: 11-235/239.0
CRYKNIVPNMDTVVKIDPLfennVKVENSDFINANWVRGFDGR-QSYIATQGPKPNTIDHFWRMIIQHEVPLIIMATNLVEGDKIKCHRYWAlfdgiKGQ
 || |||    . | .. |     .   ||.|||...| .||  ..||||||    .   ||||. |    .|.| | |.|| | |||.||         
nryanivtydhsrvvlekl....sndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywp.....dst

EKDPNLLVTesgIRvtteEVAKSRDFILRTFRLEW--NDKEHFVKHLALNNWPDYGVPSSPRAVLRAI-EVARDiryRNPG-QPIVVHCSAGVGRTGILV
 |  || ||   .|    .     |.|.||| .    . .|..| .  .  ||| |||    |||    ....|     || .| |.|||||||||| ..
skycnlrvt...lr....ktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrkitkd...slpgarpwvihcsagvgrtgafl

AVDIGIDMLLAGRRVNLTSIVQHMREDRGGMLQTFPQYEFAFKA
 .|  .      . |..   |. .||||  |.||  || | . |
vidamlrqakkqktvdifnyvkairedrphmvqtseqyvfihla

subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 1253-1491 2.5e-36 120.1 In-house 12-236 (239) alignment
Range on Protein: 1253-1491
Range on HMM: 12-236/239.0
CRYKNIVPNMDTVVKIDPLfennVKVENSDFINANWVRGFDGR-QSYIATQGPKPNTIDHFWRMIIQHEVPLIIMATNLVEGDKIKCHRYWAlfdgiKGQ
 || |||    . | .. |     .   ||.|||...| .||  ..||||||    .   ||||. |    .|.| | |.|| | |||.||         
nryanivtydhsrvvlekl....sndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywp.....dst

EKDPNLLVTesgIRvtteEVAKSRDFILRTFRLEW--NDKEHFVKHLALNNWPDYGVPSSPRAVLRAI-EVARDiryRNPG-QPIVVHCSAGVGRTGILV
 |  || ||   .|    .     |.|.||| .    . .|..| .  .  ||| |||    |||    ....|     || .| |.|||||||||| ..
skycnlrvt...lr....ktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrkitkd...slpgarpwvihcsagvgrtgafl

AVDIGIDMLLAGRRVNLTSIVQHMREDRGGMLQTFPQYEFAFKA
 .|  .      . |..   |. .||||  |.||  || | . |
vidamlrqakkqktvdifnyvkairedrphmvqtseqyvfihla

0049260 (Phosphotyrosine protein) phosphatases II 1289-1489 1e-35 118.0 In-house 2-143 (152) alignment
Range on Protein: 1289-1489
Range on HMM: 2-143/152.0
VRGFDGRQSYIATQGPKPNTIDHFWRMIIQHEVPLIIMATNLVEGDKIKCHRYWalfdgikgqekdpnllvtesgirvtteevaksrdfilrtfrlewnd
. |.   . .|||||| |||...||||. .. .  |.| |.|.| .|.||..|.                                              
idgyampfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi..............................................

kehfvkHLALNNWPDYGVPSSPRAVLRAIEVARDIrYRNPGQPIVVHCSAGVGRTGILVAVDIGIdmllagRRVNLTSIVQHMREDRGGMLQTFPQYEFA
      .    .|||.|||...  .| .... . . ....| |..||||||||||| ||| .. .      ..|.|  .|...|| | |. ... |..| 
......qylhlpwpDhgvpdlsqlllflllfiekl.aldkggpvlVHCsaGvgRtgtlvaaylml......lgvsleeavalvrekRpgavpnpgqlrfl

F
.
y

subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 1279-1492 1.3e-35 117.8 In-house 27-235 (237) alignment
Range on Protein: 1279-1492
Range on HMM: 27-235/237.0
ENSDFINANWVRGFDGR-QSYIATQGPKPNTIDHFWRMIIQHEVPLIIMATNLVEGDKIKCHRYWALFDgikgQEKdPNLLVTESgiRVTTEEVAksrDF
 .||.|||....||||  ..|||.|||  .. | ||.|. |    .|.| | |.||...|||.||   |    | . .   .| |      || .   |.
sgsdyinatylkgfdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywpstd....qpa.aygvltvs..lkkkeefs...dy

ILRTFRLEW--NDKE-HFVKHLALNNWPDYGVPSSPRAVLRAI-EVARDIRYRNPGQPIVVHCSAGVGRTGILVAVDIGIDMLLAGRRVNLTSIVQHMRE
 .|.. |    . ||  ...   .  ||| |||    |.||   ..    .. .   | ..|||||||||||.. .|  .      . |..   |. . |
tvrslllskrltlkevrlihqyqftswpdrgvpqqtaallrfrkniinrsphvsesgpwiihcsagvgrtgiflvidamlrqakekkvvdiynyvysiee

DRGGMLQTFPQYEFAFKAI
||  ..||  || | ...|
drpyiiqtkdqyvfihqti

subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 1254-1492 2.6e-35 116.7 In-house 53-275 (439) alignment
Range on Protein: 1254-1492
Range on HMM: 53-275/439.0
RYKNIVPNMDTVVKIdplfENNVKVENSDFINANWVRGFDGRQSYIATQGPKPNTIDHFWRMIIQHEVPLIIMATNLVEGDKikchrYWALFDGikgqek
|||....   | | .    ..   |  | .||||...|.   . |||||||| .| |.|||..|.. .  |.| |||||  |     ||   .       
rykdvgafdhtrvtl....qeipgvphshyinanyikGyyddklyiatqgpkkettddfwrlviekktvtivmltnlvesyk.....ywpsdae......

dpnLLVTEsgIRVTTEEVAKSRDFILRTFRL----EWNDKEHFVKHLALNNWPDYGVPSSPRAV---LRAIEVARDiryRNPGQPIVVHCSAGVGRTGIL
       .  | | ..   .  ....| |..    . ..||. | ..    |||  ||.    |   ||||. | |   ..   |.|||||||||||| .
...vcygd..iavrvdrnielpnyvirgfkvfnerdttekertvlqfhyiawpdknvpaqashvldflrainsand...keeygpvvvhcsagvGrtGti

VAVDIGIDMLLAGRRVNLTSIVQHMREDRGGMLQTFPQYEFAFKAI
.|.|| .. | .  .|..  ||. .|..|  |.|.. || | ..|.
ialdialeqlklenkvdikgivkvlrkqrkqmvqalcqyvfiynav

subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 1247-1492 4.7e-35 115.8 In-house 31-262 (283) alignment
Range on Protein: 1247-1492
Range on HMM: 31-262/283.0
KNAAQLCRYKNIVPNMDTVVKIDPLFEnnvkvensDFINANWVR---GFDGRQSYIATQGPKPNTIDHFWRMIIQHEVPLIIMATNLVEGDKIKCHRYWA
..  .  |...|||    .|..... .        |.||| ..      .  . ||..|.|  .|.  ||.|. ....  |.| |.| |. .||| .|| 
denkrknrnqeivpadqwrvelksesr........dyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfdekitaivmltklqedlrikCsqyWP

lfdgIKGQEKDPNLLVTesgirVttEEVAKSRDFILRTFRLEWN---DKEHFVKHLALNNWPDYGvPSSPRAVLRAIEVARDIRYRNPGQPIVVHCSAGV
     .| |.  .. ||     .  ..   |. || . . |  |    .. .. |  ...| .|| . ..   |  ..  .  . ...  |||||||.|.
....krGsedyGeftvt.....l..rkettsnsfiikelllrvnssakstlllahyqvidWleyg.eqaiinslvkfnkvislqteskkgPivvhCstgi

GRTGILVAVDIGIDMLLAGRRVNLTSIVQHMREDRGGMLQTFPQYEFAFKAI
|||....|.   .. .|.   |.. ..|. |||.| ...||  || .  ...
Grtavfiaasasvkdaltesvvdvfavvkimreqrmmavqtldqyklvhelv

subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 1251-1492 3.4e-34 112.9 In-house 47-232 (392) alignment
Range on Protein: 1251-1492
Range on HMM: 47-232/392.0
QLCRYKNIVPNMDTVVKIDPLfennVKVENSDFINANWVRGFDGRQSYIATQGPKPNTIDHFWRMIIQHEVPLIIMATNLVEGDkikchrywalfdgikg
.  |||||.|   . ||.. .      . .||..|| ....||  ..|||.|||.. ..| ||||. |..|  |.| |.| |||                
kknryknilpydsarvklevi....ddipdsdylnasyipsfdnekayiasqgpnaaslddfwrmvfqenvttiamvtklkegd................

qekdpnllvtesgirvtteevaksrdfilrtfrleWNDKEHFVKHLALNNWPDYGVPSSPRAVLRAIEVArDIRYRNPGQPIVVHCSAGVGRTGILVAVD
                                     |. . |    . .||| .||    ..|. |.    . . .  .|...||||||||||.....|
...................................kgddartvaqfhftewPdkdvpkhtssllkfikev.kadfGqythpliihcsagvgrtgvvisid

IGIDMLLAGRRVNLTSIVQHMREDRGGMLQTFPQYEFAFKAI
  .      | |..  .|  .|. |  |.||  || | . |.
svvahakktrmvdvfnfvtnirrkrpymvqtkeqyafiygav

0049772 (Phosphotyrosine protein) phosphatases II 1242-1492 8.1e-34 113.1 In-house 40-276 (314) alignment
Range on Protein: 1242-1492
Range on HMM: 40-276/314.0
LADLPKNaAQLCRYKNIVPNMdTVVKIdPlfenNVKVENSDFINANWVRGFdgrQSYIATQGPKPNTIDHF----------WRMII--QHEVPLIIM---
 |||..|     ||..|.|   . |.. |    .. |..||.|||..|.||   ...||||||...|.. |          |||..  .. |  | |   
vadlfln.rdknryldilpad.nrvil.p....glpvsgsdyinasyvdgf...lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivmsrd

------------------ATNLVEGDKIKCHRYWALFDgikgqekdpnllvtesgirvtteevaksrD-------FilrtfrlewndKEHFVKHLALnNW
                   ..| ..  . . ....|.                              .       |           ... .|.| . ..
evladelsrLdaAlgKtpllildgngneptaadlellk.............................eelydpelf...........erlgikylri.pv

PDYGVPsSPRAVLRAIEVARDIryrNPGQPIVVHCSAGVGRTGILVAVDIGIDMLlagrRVNLTSIVQHMREDRG-----GMLQTFPQYEFAFKAI
||...| ... .....|. ..    ..| |..|||.||.|||| .|.... .  |    .|.|  .....|. |      |..... |||| ..|.
pDgsap.lledfdeflefieea...dkggpvlvHCkaGkgRtgtfvvaaylmkll....gvsleealedvrlkRpinpnpgfieqleqyefileal

subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 1271-1503 7.5e-33 108.6 In-house 60-294 (305) alignment
Range on Protein: 1271-1503
Range on HMM: 60-294/305.0
LFENNVKVEN---SDFINANWVRGFDGRQSYIATQGPKPNTIDHFWRMIIQHEVPLIIMATNLVEGDKIKCHRYWALFD--GIKGQEKDPNLLV-TESGI
| .| ||.|.    ..| ||.|      . .| || |  .|   || | .|. |  |.|  ||.|    ||. |.|  |   .. .||.  . |  ||  
ldnnrvklegpwpheyihanyvstptnpkrfictqaplektcadfwymclqdkveaifmlcnllekgakkcleyfaskdkdvlefeekgqkisvkfessv

RVTTEEVAKSRdFILRTFRLEWN-DKEHFVKHLALNNWPDYGVPSSPRAVLRAIEVARDIRyrnpgQPIVVHCSAGVGRTGILVAVDIGIDMLLAGRRVN
..  .. ||..      . .|    | . |.|   ..||| |||..  |.|  .| ||  .      |||||||||.|||| .| ..  .| ||||. ..
tlkfrkdakak.vtetvlviegpgekarkvthyhwidwpdrgvpaadlailellekarpsk.....gpivvhcsagigrtgsvvmleyildqllagqiie

LT-SIVQHMREDRGGMLQTFPQYEFAFKAIGSFARLYGMLN
 |  |.|..||.|   .||  || |  . |  . |  ..|.
dtdkilqkireqrnnsiqtdaqylfvhqvilnyfrkkklld

subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 1254-1491 6.1e-32 105.5 In-house 60-284 (305) alignment
Range on Protein: 1254-1491
Range on HMM: 60-284/305.0
RYKNIVPNMDTVVKIDplfennvKVENSDFINANWVRG-FDGRQSYIATQGPKPNTIDHFWRMIIQHEVPLIIMATNLVEGDKIKCHRYWALFDGIKGQE
||...  .  ..||.|       |   ||.| ||.|   .   . .|..|||  .|||.|| |.||. |  |.|  . ||  |.|| .|| .  | | . 
ryqdvpcqdqsavkld.......kpspsdyihanyvgcpmipekrficaqgpldqtidefwwmviqnkveqivmlcktvelgklkcaqywpaaqgeklel

KDPNLLVTESGirvtTEEVAKSRDFILRTFRLEW-NDKEHFVKHLALNNWPDYGVPSSpraVLRAIEVARDIRYRNpgQPIVVHCSAGVGRTGILVAVDI
|   ..   ||    .  . .  .  . ...| .  |..  |.||  ..||| |||      | ..|.   ||  .   |||||||||.|||| .||.. 
ksgivvenvsg....skpmerdaeiqitllnltysgdqkmsvrhlqwtewpdrgvppc...kltslellsairgsk..vpivvhcsagigrtgtivaiey

GIDMLLAGRRV-NLTSIVQHMREDRGGMLQTFPQYEFAFKA
 .. .   ...  .  .|. .|..|   .|.  || |  . 
ilekiaenkpcppmpelvkalrdqrafsiqndvqylfihrv

Pkinase Protein kinase domain 99-246 1.6e-31 99.3 Pfam-A 84-226 (260) alignment
Range on Protein: 99-246
Range on HMM: 84-226/260.0
DAERVAAEIKLLEENTVAFLIKETLKAIVHMHVHHVMHRDIKGGNILLDDEYAVCLTDFDTAYPYdPAEQATHFHAVGTPYWMAPEIAAcdypEGYAYDE
|  .. .. . |.|... ......|... ..| ....|||.|  |||||... ....||  |  .   .. .. . |||...||||.      ..  |..
dlfdllkkkgklseeeikkialqilegleylHsngiiHrDLKpeNiLldekgelkiaDFGlakkl.eksseklttlvgtreYmAPEvll....kakeytk

RCDVWSLGVTAIELSEGQPPLFHLPRDKALGEVLKQGPPTLKHADLWS
..|||||||. .|| .|..|. .  ....|  . |.  ..|..   .|
kvDvWslGvilyelltgklpfsgeseedqlelirkilkkkleedepks

0051082 (Phosphotyrosine protein) phosphatases II 1281-1490 4.3e-31 102.9 In-house 3-147 (151) alignment
Range on Protein: 1281-1490
Range on HMM: 3-147/151.0
SDFINANWVRGFdgrqsYIATQGPKPntidHFWRMIIQHEVPLIIMATNLVEGDkiKCHRYWALFDgikgqekdpnllvtesgirvtteevaksrdfilr
||.||...| |.     .....|| .    .|.... .. .  |.. ....| .  .|..|.   .                                  
sdyinfsyvtgg.....lyrsggpla....dflellkelgiktivnlrseeerg..ycpeylpelg..................................

tfrlewndkeHFVKHLALNNWPDYGVPSSPRAVLRAIEVARDiryrNPGQPIVVHCSAGVGRTGILVAVDIGIDMllagrrVNLTSIVQHMREDRGGMLQ
          . |.|. . .|||.|.| |. |||...|...|    ....|..||||||.||||.|||... . .      |.| ......|. |.|. |
..........ievlhipildwpdpglplsfdavleflellld....kkngpvlvHCsaGkgRTGtlvalylmllg......vsleealeeyrlkrpgvvq

TFPQYEFAFK
.. |. | ..
pnqqflfqlf

subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 1252-1500 4.6e-30 99.2 In-house 40-273 (281) alignment
Range on Protein: 1252-1500
Range on HMM: 40-273/281.0
LCRYKNIvPNMDtVVKIDPLFENNVKvENSDFINANWVRGFDGRQSYIATQGPKPNTIDHFWRMIIQHEVPLIIMATNLVEGDKIKCHRYWAlfdgikgq
  || || | .| . ...  ..   | . .|.| ||..|    .. || ||||| .|   ||||| | .   |.|  ...| .. ||  |.         
knrylni.pcld.isrvqlkvkmpnk.nstdyihanyirspflkrgyiltqgpkketradfwrmiwqenttaivmlcqfletnrekcaeyfp........

eKDPNLLVTESGIRVTTEEVAKSRDFILRTFRLEWNDKEHFVKHLALNNWPDYGVPSSPRAVLRaieVARDIRYRNpgQPIVVHCSAGVGRTGILVAVDI
 ..    .    . |. |. .  . ..   . | .. . ... |   ..|||. || |   .|.   . | || |    | |.||||||||.| |.||.|
.rnahcclqfdklsvsyedstvnkslvttrlnlsyegetrlithwlwkewpdwqvpessevmlk...ilrkirars..tppvihcsagvgrsgtlmavei

GIDMLLAGRR-VNLTSIVQHMRE-DRGGMLQTFPQYEFAFKAIGSFARLYG
 .. . .     ..  || |.|   |   .||. || . .| .  |   | 
alqsihshftlpdikqivshlrvtgraasvqtlqqymliwkvlldfgvayk

subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 1284-1498 5.7e-30 99.1 In-house 78-281 (301) alignment
Range on Protein: 1284-1498
Range on HMM: 78-281/301.0
INANWVRGFDGRQSYIATQGPKPNTIDHFWRMIIQHEVPLIIMATNLVEGDKIKCHRYWALFDGikgqekdPNLLVTESGIRVTTEEVAKSRDFILRTFR
| |||.      . .|||||| .|| . || |..|..|  |.| .. ||  . ||. | ..  .        .| .    |.....|.  . . . ||..
ihanwiptsGhphrfiatqgPlkntsedfwamlvqydvekivmlgqkvekleekceeylpvkis.......ekldigrfkikiknkelilnkkiskrtle

LEWNDKE---HFVKHLALNNWPDYGVPSSPRAVLRAIEVARDIRyrnpgQPIVVHCSAGVGRTGILVAVDIGIDMLLAGRRVNLTSIVQHMREDRGGMLQ
.|   ..   . | |   ..|.|.||| |   .   .|.... .     .|||||||||.||.  ... ..    ..| ....||  ..|.||.|   .|
vedstgkfatrtvthyqysewtdrgvPkshaelfdlmelvkkse.....kPivvhcsaGiGrsvafigteylareveadptieltealkhlrehrwngvq

TFPQYefAFKAIGSFARL
|  |    .  .|.  ||
tnsql..ywmtlGtvyrl

subfamily_CG7180_pd Subfamily CG7180 1279-1491 7.3e-30 98.6 In-house 68-285 (296) alignment
Range on Protein: 1279-1491
Range on HMM: 68-285/296.0
ENSDFINANWVRGFDGRQSYIATQGPKPNTIDHFWRMIIQHEVPLIIMATNLVEGDKiKCHRYWALFDGIKGQEKDPNLLVTESGIRVTTEEVAKSRDF-
|.||.||| .| .|   . || |..|| .|.| |||.. ..|.  ... |.  .  | ... ||      . .|   ... ...   ... ..   .   
eksdYinavyvdsflkkkeyivteapkketvdefWrlvydeeisavvvLtktfdfak.mypsywpnkskeqygeifveiveekqyanlkirtfkltkkiv

ILRTFRLEWNDKEHFVKHLALNNWPD-YGVPSSPRAVLRAIEVARDIRYRN----PGQPIVVHCSAGVGRTGILVAVDIGIDMLLAGRRVNLTSIVQHMR
 |   . . . ..  ||.. |  |.    ||.|  |..  .. .| .| ..      .|.||..| |..|.|. .|.|. ....    .|..   |. .|
alteqekqvkaetRivklfqlteWeledkvPlstnalielrrrvrlwrekvdedpeegPvvvvssdGasRsGvylaidanlelvekeeevdvFeavktlr

EDRGGMLQTFPQYEFAFKA
..| .....  .| . .  
rsRpqLvenveeYkyiYdv

subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 1253-1497 1.6e-29 97.7 In-house 51-345 (350) alignment
Range on Protein: 1253-1497
Range on HMM: 51-345/350.0
CRYKNIVPNMDTVVKID----PLFENNVKVENSDFINANWVRGF------DGRQSYIATQGPKPNTIDHFWRMIIQHEVPLIIMATNLVEGDKIKCHRYW
 |||||.|   . ||.     .    .  .. .|.||||...        .    |||||.| |.|.| |...|.. .|..|.. |..|| .  ||.|||
nrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvkvilsltsdvelnlekcyrYW

AL--FDG--IKGQEKDPNLLVTE------SGIRVTTE------EVAKSRDFILRTfRLEWNDK-EHFVKHLALNNWPDYGVPSSPRAVLRAIE-------
    .|.  .| ..|  |   ..      .... ..       .. . .|.   |  ..      . | .| ..||.| ..   |. .|.|.|       
qegsydditvklaskwenimgindsslysadvkkeasdndnisddndlkdnnslt.aitlaasdPyvvyqlqvknWkDlslllnPesilqalevkndlid

--VARDIRYRNPGQPIVVHCSAGVGRTGILVAVDIGID---MLL--AG----------RRVNLTSIVQHMREDRGGMLQTFPQYEFAFKAIGSFAR
  .|.     . ..||.|||||||||||.||..|  .    .|                |  .. ||...|. |  | |.  |. | ..|.  . .
dlfaeshldnarsspilvhCsaGvGrtGtlvtlDsllsdfeilenltkesrkldvaaktrDlisiivnelrkqrismvqnldqfifiYeallfyfa

0044763 (Phosphotyrosine protein) phosphatases II 1274-1487 1e-27 92.4 In-house 11-162 (178) alignment
Range on Protein: 1274-1487
Range on HMM: 11-162/178.0
NNVKVENSDFINANWVRGFdgrqSYIATQGPkpntiDHFWRMIIQHEVPLIIMATNLVEGDKIKCHRYWALFDGikgqekdpnllvtesgirvtteevak
|   .| ||.|||... ..     |.....|      ...... .. . .|.. |. .|. ..||..||    |                          
nleglersdyinaseilpg....lylgslpp.....addlellkelgithivnlteelelgflkcdpywpeeag..........................

srdfilrtfrlewndkehfVKHLALnNWPDYGVPSSPRAVLRAIEVARDIRYrNPGQPIVVHCSAGVGRTGILVAVDIGIDMllagrRVNLTSIVQHMRE
                   ...| . ..||.|||.... .|...|  ....  ..| |..|||||||||.| ||| .. . .     ...| ......||
...................iqylhi.pipDhgvpdllehflefvefieeald.ekggpvlVHCsaGvgRsgtlvaaylmkkl.....glsleeaielvre

DRGgMLQTFPQYEF
 |  . ... |...
rRp.ivpnpgqlrq

subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 1254-1492 1.1e-27 91.8 In-house 48-267 (288) alignment
Range on Protein: 1254-1492
Range on HMM: 48-267/288.0
RYKNIVPNMDTVVKIDplfennvkvENSDF-INANWVRGFDGRQSYIATQGPKPNTIDHFWRMIIQHEVPLIIMATNLVEGDKIKCHRYWALFDGIKGQE
||.|.     | ||..         ...|| |.|| |     ..  | .| |   ||. .|.|... .|  |.| ..|.|  | |   |. .  | | . 
ryenlprcditrvkls.........ddpdfyiaanvvssakykrrlicaqaPlngtieelWkmllesdveyivmlcellekGkeksaeyfPsklGekari

KDPnllvtesG--IRVTTEEVAKSrdFILRTFRLEW-NDKEHFVKHLALNNWPDYGVPSSPRAVLRAIEVArdiryRNPGQPIVVHCSAGVGRTGILVAV
.            ...  ... |     . ..| .   ... .||.| |..|.| ||| .  . || .||      ..  .|||||.|||||||| |. .
grl.......ctvvkkkradidkl..vkvsllriskegeekvivkilhlleWdddgvPenylsplrllevl.....kslqkPivvhssaGvGrtgtlili

DIGIDMLLAGRRVNLTSIVQHMREDRGGMLQTFPQYEFAFKAI
 | ...|     . . |.....||.|   .||  || .... .
lialeslrlddflgirsllaklreerfkaiqtemqylyvhrcv

subfamily_ptpA1_pd Subfamily ptpA1 1250-1451 4.8e-27 89.7 In-house 48-251 (418) alignment
Range on Protein: 1250-1451
Range on HMM: 48-251/418.0
AQLCRYKNIVPNMDTVVKIDPLFENnvkvENSDFINANWVRGFDGRQsYIATQGPKPNTIDHFWRMIIQHEVPLIIMATNLVEGDKIKCHRYWALFDGIK
.   || ||.|   | |..  . ..    | ||.||||.. |   .| .|.|||| ||||  ||||. .  . .|.| .   |  .||| |||    | .
tsknrytnilpvnhtrvqlkkiqdk....egsdyinanyidgaypkq.fictqgplpntiadfwrmvwenrcriivmlsresencrikcdrywpeqigge

GQEK--DPNLLVTESGIRVTTEEVAKSRDFILRTFRLEWNDKEHFVKHLALNNWPDYGVPSSP---RAVLRAIEVARD--IRYRNPGQPIVVHCSAGVGR
      . | ..    . .        |. | |  || .. . . . .   . |||. .|      | .|..|   ..  |   .   ||.|||||||||
qfsiygngnevfgtysvelveviqdpereiitrnirltfegetrditqyqyegwpdhnipdhtqpfrqllhsitnrqnqiipssdrnvpiivhcsagvgr

TGILVAVDI
|| ...  |
tgtfctavi

PTPc_DSPc_SM00012 1393-1492 5.1e-27 89.5 In-house 2-103 (105) alignment
Range on Protein: 1393-1492
Range on HMM: 2-103/105.0
VKHLALNNWPDYGVPSSPRAVLRAIEVARDIRYRNP-GQPIVVHCSAGVGRTGILVAVDIGIDMLLAG-RRVNLTSIVQHMREDRGGMLQTFPQYEFAFK
|||.  ..||| |||... ..|....  .. .. .  ..|.||||||||||||..||.|| ...| .. ..|..  ||...|. | || ||. || |  .
vkhyhytgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqylflyr

AI
|.
al

subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 1282-1500 6.3e-27 89.1 In-house 68-280 (312) alignment
Range on Protein: 1282-1500
Range on HMM: 68-280/312.0
DFINANWVRGFDGRQSYIATQGPKPNTIDHFWRMIIQHEVPLIIMATNLVEGDKIKCHRYWALFDGIKGQEKdpNLLVTESGIRVttEEVAKSRDFIL-R
 .| ||.|.     . ...||||  ||. |||.. .      ||. . .||    || .| .   |.   |     . ||.   .  |   ||.| |  |
fyihanfvkictkperfvctqgplentcthfwqlalslgstsiillcgfvedgsekcakyisdivgfvdled..hrvyteyctei..eiggkskdkithr

TF--RLEWNDKEHFVKHLALNNWPDYGVPSSPRAVLRAIEVARdiryrNPGQPIVVHCSAGVGRTGILVAVDIGIDMLLAGRRVNLTSIVQHMREDRGGM
 .   .    .|  ..|     |||.|.| |  . || .   .     .  .|.. |||||||||| |. ..  |  |   |. |.  .   .| ||   
vlkvvvkatgqesklnhyqwaswpdhgmpdscdtalrllsavk.....kdkkpviahcsagvgrtgtlaliesmiaalrhprkqnvkdsfvllrkdrars

LQTFPQYEFAFKAIGSFARLYG
...|||| .|....  |    |
vrvfpqyvyalrcvleflyskg

subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 1277-1504 5.8e-26 86.1 In-house 53-265 (267) alignment
Range on Protein: 1277-1504
Range on HMM: 53-265/267.0
KVENSDFINANWVRGFDGRQSYIATQGPKPNTIDHFWRMIIQHEVPLIIMATNLVEgDKIKchRYWAlfdGIKGQEKDPNLLVTESGIRvtTEEvaksRD
. .. ..||| .| |.  .. .|.||.|  ||| .|. .|....|| |.. |.  . |.|.  ..|       || |  . |. |  .    ||     |
rtkeeeyinasyvegyktknafivtqdplkntitdfltvihdqkvpvivlltkvft.dnir..lfwP...Pkmgqakkyqdltvehsle..kee....nd

FILRTFRLEWndKEHFVKHLALNNWPDYGVPSSPRAVLRAI-EVARDIRYRNPGQPIVVHCSAGVGRTGILVAVDIGIDMLLAGRRVNLTSIVQHMREDR
. . |. |..  |.   . ..|  .  . . .  .  |. .  .    .  | ..|.||.||.||||.| .. .|  .. .     ...   ....|. |
yqiitlelkf..knesahnvtlyyykkwnintnnkpylkplfgilaknqlengnrPlvvacsdGvGrsGtflvidsqleraktegvsdifdflrkirsqr

GGMLQTFPQYEFAFKAIGSFARlyGMLNH
 |...|  .| .  . .  .|.  |.|..
iglvdtkeryiyihellaeyae..grlke

subfamily_egg_pd Subfamily egg 1248-1497 9.7e-26 85.1 In-house 39-271 (307) alignment
Range on Protein: 1248-1497
Range on HMM: 39-271/307.0
NAAQLCRYKNIVPNMDTVVKIdpLFENNVKVEnsDFINANWVRGFDGRQSYIATQGPKPNTIDHFWRMIIQHEVPLIIMATNLVEGDkiKCHRYWAlfdg
|  . .| | .  .  . ||.   ...   ..  ||| || |.|      .| .| |  || | ||||. | ||. |.| |  .| .  .|. ||     
nnlekarskrvhckdssrvkl..elrrGqyld..dfihanrvkGkpllnefilaqaplkntvddfwrmvfqeevqyivmltsrkese..rceyywp....

ikGQEKDPNLLVtESGIRVTTEEVAKSRDFILRTFRLE---WNDKEHFVKHLAlNNWPDYGVPSSPRAVLRAIevardiryRNPGQPIVVHCSAGVGRTG
    |.|.  .|   ..|... .| .  | ..|  .|     .|.| |..|    ..   .   ||  ||| .        ||  .|.||..  || ...
..kaesdslvtv.pGslrienlkvdskadplfrvtklklvGgddeerflehwq.gdvnnssdvysplrvlrkl........rnlskpvvvqdilGvskaa

ILVAVDIGIDMLLAGR--RVNLTSIVQHMREDRGGMLQTFPQYEFAFKAIGSFAR
 |||..| .  || |   .  .   |. .|  |   ...  .| | .. .  | |
tlvaieiallsllrGpitkslvlravvflrlrrrlsvesvllylfvyrlvlfffr

subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 1272-1490 1.3e-25 85.0 In-house 48-264 (285) alignment
Range on Protein: 1272-1490
Range on HMM: 48-264/285.0
FENNV--KVENSDFINANWVRGFDGRQ-SYIATQGPKPNTIDHFWRMIIQHEVPLIIMATNLVEGDKIKCHRYWALFDGIKGQEKDPNLLVTESGIRVTT
 |  |  |  . |.| |.|.|     | .||.|||| |.|.  ||.|| | ..  ..|   |.||   ||  |.    |   .    .. .||      .
eetrvvlknhdrdyihaswmrmpgkdqstyittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekcalyypeklgevvkfgkyeitlteckeeaia

EEVAKSrdfiLRTFRLE-WNDKEHFVKHLALNNWPDYGVPSSPRAVlraIEVARDIRYRNPG-QPIVVHCSAGVGRTGILVAVDIGIDMLLAGRRVNLTS
  . ..    |     |  . .  ...|. .  |||   |   | .   ||. . ..  ||  .||.||||||||||  .| .|     ..    ...  
gtilna....ltvintedasseplymnhvqvpwwpdqlapedarpm...ielykwvkkvnpkekpicvhcsagvgrtatfvgidyatirimenpniemld

IVQHMREDRGGMLQTFPQYEFAFK
||. ||  |   .|.. |. | . 
ivremramrfqavqshmqflflyv

subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 1302-1484 1.3e-25 84.5 In-house 97-276 (302) alignment
Range on Protein: 1302-1484
Range on HMM: 97-276/302.0
QGPKPNTIDHFWRMIIQHEVPLIIMATNLVEGDKIKCHRYWAlfDGIKGQEKDPNLLVTESGIRVTTEEVAKSRDFILRTFRLEW---NDKE-HFVKHLA
  || .|.. .| .| |..| ...  ...||... ||  |..  | ..|. |  .  |.   ..   || .  ..| | |  ..    ..|  . |. ||
ivpkkstlekhwalieqynvaivvqlcsfvedeekkcaeyys..dkvggelkfgrytvktvsvktdleeftdkksfklytveiknekkkkkvkktvdila

LNNWPDYGVPSSPRAVLRAIEVARDirYRnpgQPIVVHCSAGVGRTGILVAVDIGIDMLLAGRRVNLTSIVQHMREDRGGMLQTFPQ
   |||.| |  . . |  .       |.   . ..||||||||||| |||.  ||.. .  .  .| |||. .|. | | .|.  |
fsawpdhGapkeaytaldilkfces..yk...knvlvhcsaGvGrtGtlvaikyGiqlcskkkvtdllsivlpvrqcryGavqdeqq

subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 1254-1492 5.3e-23 76.0 In-house 57-286 (310) alignment
Range on Protein: 1254-1492
Range on HMM: 57-286/310.0
RYKNIVPNMDTVVKIDplfenNVKVENSDFINANWVRGFDGRQSYIATQGPKPNTIDHFWRMIIQHEVPLIIMATNLVEGDKIKCHRYWALFDGI--KGQ
|| ..|   .. ||.        |    |.| ||.|.    |...| .|||   ||  |||||.|     |..  . .|  . ||  ||  .      | 
rysdvvcldtsrvklk.....idksryedyihanyvktnylrstficsqgplqhtiidfwrmifqeraesilllckvgeegrpkcvgywpslgvtetygc

EKDPNLLVTESGIRVTTEEVAKSRDFILrTFRLEWNDKEHFVKHLALNNWPDYGVPSSPRAVLRAIEVArDIRYrnpgQPIVVHCSAGVGRTGILVAVDI
 .  ||  .   . .    |.   | .        | ||  |. .   |||| |||      .    .| ..|.     | |||||||..|....||...
irvtnlsesseefeicnlavtfvpdnvp.vdeqpanlkelrvslikwpnwpdrgvpdekchtvpqrlla.qvrh....gpcvvhcsagkdrlyvvvalkl

GIDMLLAGRRVNLTSIVQHMREDRGGMLQTFPQYEFAFKAI
 || |  | .|..  .. ... .|    ||  || .  .  
kidkldrglkvdaeevktellksraiciqtelqyliidrvr

subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 1251-1415 5.3e-22 73.0 In-house 35-188 (297) alignment
Range on Protein: 1251-1415
Range on HMM: 35-188/297.0
QLCRYKNIVPNMDTVVKIdplfenNVKVENSDFINANWVRGFDGRQ--SYIATQGPKPNTIDHFWRMIIQHEVPLIIMATNLVEGDKIKCHRYWALFDGi
.  ||..|.   || ||.         . ..|.|||..|   |  .   || .|||  .|.| ||... ...|  |.| ..| |. . ||  ||   .. 
rknryrdilatddtrvkl......lrviterdyinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmvaklqedGrdkcapywpsvvq.

kGQEKDPNLLVTEsgIRVTTEEvakSRDFILRTFRLEWNDKEHFVKHLALNNWPDYGVPSSPRAVLR
 .. | ....|    .  |..|       ||  ..| . ...  |.|    .|||.||||    . |
.erlkagdvvvef..lsstsde...fdrviltelqliyrsesrvvrhvqflswpdhGvpsdledlvr

subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 1280-1458 4.7e-21 69.5 In-house 89-294 (349) alignment
Range on Protein: 1280-1458
Range on HMM: 89-294/349.0
NSDFINANWVR--GFDGRQSYIATQGPKPNTIDHFWRMIIQHEVPLIIMATNLVEGDKIKCHRYWALFD--G--IKGQEKDPNLL-VTESGIRVT-TEEV
  |.||||...   ..  . ||||| | | |.| |...|.  .|.|..  ..  | .  ||..||   .  .  .| |.   .   |  .  ||   .. 
lddyinanylkltrisvekkyiatqaPlPstvddfykvillngvklvlsLnddkelslekcdiywqelsysnitvklqnsslyianvqGnslrvstvkdt

AKSRDFILRTFRLEWNDKEH----------FVKHLALNNWPDYGVPSSPRAVLRAIEVARDIRYR---------NPGQPIVVHCSAGVGRTGILVAVDIG
..  | . .   |. .|...           .  | . ||.| ..   | ..|.|.||  |.            .   ...|||||| ||||.|| .|. 
dndndnnkknCdlpddddddaillavekPyellqlqvknwldlslllnPisilqalevkndliddlfarlyldtdqlstllvhcsaGcGrtGvlvtldll

IDMLLA
...|  
lsilep

0048076 (Phosphotyrosine protein) phosphatases II 1382-1490 7.7e-21 69.7 In-house 36-137 (145) alignment
Range on Protein: 1382-1490
Range on HMM: 36-137/145.0
FRLEWNDKEHFVKHLALNNWPDYGVPSSPRAVLRAIEVARDIRYRNpgQPIVVHCSAGVGRTGILVAVDIGIDmllagRRVNLTSIVQHMREDRGGMLQT
.  | .. |... ..   .|||.|||.... .|...|  .... ..   |..||||||||||| ||| .. .      ..|.| ......|. | |. ..
ltselellerlgiqylylpwpDhgvpdllellleflefieealkeg..gpvlVHCsaGvgRtgtlvaaylmll.....lgvsleealelvrsqrpgavpn

FPQYEFAFK
. |..| ..
pgqlrflye

subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 1280-1505 1.2e-20 68.9 In-house 45-266 (290) alignment
Range on Protein: 1280-1505
Range on HMM: 45-266/290.0
NSDFINANWVRGFDGrQSYIATQGPKPN-------TIDHFWRMIIQHEVPLIIMATNLVEGDKI----KCHRYWAlfdgikgQEKDPNllVTESGIRVTT
|.|.| || |   .| .  |.|| |. .       || .|| |. | .|  ..|  .  | ..      | .|         .. . .  ..  |. |  
nddyiHAnrvtcpng.lrliltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCakYvp.......esvgee..lkfkgltvkC

EEVAKSRDFILRTFRLEWNDKEH-FVKHLALNNWPDYGVPSSPRAVLRAIEVardIRyrNPGQPIVVHCSAGVGRTGILVAVDIGIDMLL-AGRRVNLTS
 .  |  |.. |.  ....|.|.  |.|  |..| .  |. ... .| .|.    ..  . . |..|||  |. |  .| |...|  ..      |.|..
kskekeddvetRelvvkfddeeeftvtHsllkgWnklnvqedtktllsliqk...vk..asktpvivHcvdGiSrsAalaaiilgyQkiaetsgsvkled

IVQHMREDRGGMLQTFPqyEFAFKAIGSFARLYGMLNHL
... .|. |  ....    |.||   | . ..  .|.. 
vlkalrkqralaitsal..elafvdagivllaievldqf

0048179 (Phosphotyrosine protein) phosphatases II 1385-1488 1.6e-19 65.5 In-house 41-137 (144) alignment
Range on Protein: 1385-1488
Range on HMM: 41-137/144.0
EWNDKEHFVKHLALNNWPDYGVPSSPRAVLRAIEVARDIRYrnPGQPIVVHCSAGVGRTGILVAVDigidmLLAGRRVNLTSIVQHMREDRGGMLQTFPQ
|... |... ..   .|||.|||...  .|...|  ....   .| |..||||||||||| ||| .     |.  ....| ......|. | |. ... |
epefleregiqylhlpwpDhgvpdllellleflefieeale..eggpvlVHCsaGvgRtgtlvaay.....lmkklglsleealalvrsrrpgavpnpgq

YEFA
..| 
lrfL

subfamily_CG42327_pd Subfamily CG42327 1232-1416 1.3e-17 58.4 In-house 11-186 (319) alignment
Range on Protein: 1232-1416
Range on HMM: 11-186/319.0
FDALPLNLGNLADLPKNAAQLCRYKNIVPNMDTVVKIDplfeNNVKVENSDFINANWVRGFD-GRQSYIATQGPKPNTIDHFWRMIIQHEVPLIIMATNL
|. ||  . .  ..|  . .  |. |.||  .| |  .    .  . ... ...|..|||.|  . ||||.| .  ..   |||.. .     |. .|.|
frdlPqliaradevPvtskdksrvinvvPlPetrvvlq....rigdddkdeyldasyvrGyddapnsyiaaqvsledsssdfwrtvweqqsrvivqltdl

VEGDKIKCHRYWALFDGIKGQEKDPNLLVTESGIRVtTEEVAKSRdFILRtfRLEwNDKEHFVKHLALnNWPDYGVPSSPRAVLRA
 |    .| .|.   .. ....   ..|||  |  |  .. | |  ..|.  |.. ...   . |    .|.. .||....|..  
selGikvcaeylPtketldntslyGdilvtlkgrev.kdryaist.lllk..rvd.keesrelthywy.kwleaevPaeeaaliam

subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 1300-1492 3.9e-17 57.2 In-house 39-217 (255) alignment
Range on Protein: 1300-1492
Range on HMM: 39-217/255.0
AtqgpkpnTIDHFWRMIIQHEVPLIIMATNLVEGDKIKCHRYWALfdgikgqEKDPNLLVTESGIRVTTeevaKSRDFILRTFRLEW----NDKEHFVKH
        |.|.|...|.| .   ..| ... | .. ||..|. |       |||  | ...  . .|      | | .||| ..        | | |||
l.......tvdkfyqtivqtktevvvmlcdfaeegvekcssyfpl.......ekdeklkladvnvtttk....ssadvvlrtleitstlgekkkthtvkh

LALNNWPDYGVPSSPRAVLRAIEVARDiryrnPgQPIVVHCSAGVGRTGILVAVDIGID-MLLAGR-----RVNLTSIVQHMREDRGGMLQTFPQYEFAF
   . |..   |  .| .|  . |.||       ...|||||.|.||.  .| ...    |... .      ..  |.....|. | . ..|  |  |..
ysykGWieknaPelareilnilkvvrd.....s.ksvvvhCstGiGrsaafvlaelvyqkmirsldttetveldylslleelrskrkraihtPlqlafsi

KAI
  .
lmv

subfamily_CG42327_pd Subfamily CG42327 1428-1497 1.1e-15 52.1 In-house 246-316 (319) alignment
Range on Protein: 1428-1497
Range on HMM: 246-316/319.0
PGQPIVVHCSAGVGRTGILVAVDIGIDMLLAG-RRVNLTSIVQHMREDRGGMLQTFPQYEFAFKAIGSFAR
   |.||||| ||||||...| || |  |    | |..  .|...|.||.  ..|  |||| .| .  .|.
sqGPlvvhcsdGvGrtGlviasdiairsleeskrsvdiPqlvssvrrdrasavltkeqyefiykvlseyak

subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 1365-1492 3.1e-15 50.4 In-house 63-190 (440) alignment
Range on Protein: 1365-1492
Range on HMM: 63-190/440.0
RVTTEEVA--KSRDFILRTFRLEWNdkEHFVKHLALNNWPDYGVPSSPRAVLRAIEVARDIRYRNPGQPIVVHCSAGVGRTGILVAVDIGIDMLLAGRRV
||  |||    . |.|  ..    .   . .|.   . ||| |||     ||. |.   . . .    |..||||||.||||...|||  .       ..
rvmleevkgvpdsdyinasyingie..srtlkqyhyqgwpdkgvpkfagpvlkmiqdvnesqekagngpllvhcsagagrtgviiavdsilreakrsdqi

NLTSIVQHMREDRGGMLQTFPQYEFAFKAI
.. |... ||..|  |.||  || | ..|.
difsfinsmrnnrpqmvqtpeqyafvheav

Pkinase_Tyr Protein tyrosine kinase 118-235 6.6e-15 44.8 Pfam-A 108-221 (259) alignment
Range on Protein: 118-235
Range on HMM: 108-221/259.0
LIKETLKAIVHMHVHHVMHRDIKGGNILLDDEYAVCLTDFDTAYPY-DPAEQATHFHAVGTPYWMAPEIAACDYpegyaYDERCDVWSLGVTAIELSE-G
.. .  |.. ... ....|||.   |.||...  | ..||  |    .  .. .. .|     |||||.          . .. |||| ||. .|. . |
falqiAkGmeyLeskklvHrdLaarNvLleenkvvkisDfGLardiekddyykkkekaklpvkWmapEslkekk.....ftsksDvWsfGvllwEiftlg

QPPLFHLPRDKALGEVlKQG
. |. .|.  ..| .. |.|
espypglsneevlekl.keg

subfamily_hpo-7_pd Subfamily hpo-7 1307-1490 4.9e-14 46.8 In-house 45-221 (263) alignment
Range on Protein: 1307-1490
Range on HMM: 45-221/263.0
NTIDHFWRMIIQHEVPLIIMATNLVEGDKIKCHRYWALFDGIKGQEKDPNLLVTESGIrvttEEVAKSRDFILrTfrLEWNDKEHFVKHLALNNWPDYGV
.||| |...| | .   ..| ..  | .. || .|. |    | . .. |. .|..      . . |.....  |  |.   | | |||   . |..   
qtidkfyqtivqtktevvvmLcDfneegvekcssyfPlekdekqklanvnvcttkvqs....dvllktlells.t..lgeKkkthtvkhysykgWieknd

PSSPRAVLRAIEVARDIRyrnpgqPIVVHCSAGVGRTGILVAVDIGID-MLLAGR-----RVNLTSIVQHMREDRGGMLQTFPQYEFAFK
|  .| .|. ..|||. .      ..|||||.|.||.   . ...    |... .      ..  |.....|. | . ..|  |  |.. 
pelareilnilkvarnsk......slvvhcstGiGrsaafsvaElvyqkmirsldttstveldylsLleelrssrkraihtPmqLafsil

subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 1294-1490 1.3e-13 45.6 In-house 3-198 (199) alignment
Range on Protein: 1294-1490
Range on HMM: 3-198/199.0
GRQSYIATQGPKPNTIDHFWRMIIQHEVPLIIMATNLVEGDKIKCHRYWALFDGikGQEKDPNLLVTESGIrvTTEEVAKSRDFILrTFRLEWNDKEHFV
|.. ||||| |  .|.  ||.|. .     |.|  .     .     ||.  .   |  |  .| ||   |  ||.       .|| |           .
gqrryiatqhplretmadfwqmvwetgsghivmvnddqknkeadypfywpttes..gtgkygslsvttkti..ttkpdytitalil.tnnttappstrei

KHLALNNWPDYGVPSSPRA---VLRAIEVARDIRyRNPGQPIVVHCSAGVGRTGILVAVDIGIDMLLAGR--RVNLTSIVQHMREDRGGMLQTFPQYEFA
 |  .  | .   |        |. . ||..    ..   |..|||| | | ||..||.|||.      .   |.|  . . .|. | |.. ....|.| 
shyqftswkekttpnvalfvgfvvasrevskkye.qekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfi

FK
..
yq

subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 1258-1513 1.7e-13 44.9 In-house 44-296 (303) alignment
Range on Protein: 1258-1513
Range on HMM: 44-296/303.0
IVPNMDTVVK--IDPLFENNVKVENSDFINANWVRgFDGRQSYIATQGPKPNTIDHFWRMIIQHEVPLIIMATNLVEGDKIKCHRywaLFdgikGQEKDp
.| |||      .  |   .||. .| .| |...  .| ..  | || | . |   ||.|||.  |  ...     | ||.  .    .|     ...| 
fvknmdknrfvdvicldhskvklsdssyihasyle.ldsskkailtqlplshtaadfwqmiieqkvkcvlllltdseydklggds...vf....prnqd.

NLLVTESGIRVTT-EEVAKSRDFILRTFRLEWNDKEHFVKHLALNNWPDYGVPSS--PRAVLRAIEVARDIRYRNPGQPIVVHCSAGVGRTGILVAVDIG
 |   |  |||    .|  .  . |.   .   |   |..    ..||   .||   |. | .  ..   .|   ...| |    .|.||.| .   .  
flkfeersirvgefkrvelgdgwvlkvlsvsngdyksflhvhhykawphnsipsdgspkfvkqiwqlqsvlrkysdstptvymslsgcgragtfalfeta

iDMLLA--GRRVNLTSIVQHMREDRGGMLQTFPQYEFAFKAIGSFARLYGMLNHLLSVQGDEE
  . |      ..|   .. .|. |   .| . |. . .  .       |. .  .. . ..|
.hlslhseqasldlvkclenvrngrlhavqnlsqfsvvytllaehvldngicklaipkkpnde

subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 1294-1490 1.7e-13 45.2 In-house 2-197 (198) alignment
Range on Protein: 1294-1490
Range on HMM: 2-197/198.0
GRQSYIATQGPKPNTIDHFWRMIIQHEVPLIIMATNLVEGDKIKCHRYWALFDGikGQEKDPNLLVTESGIrvTTEEVAKSRDFILrTFRLEWNDKEHFV
|.. ||||| |  .|.  ||.|. .     |.|  .     .     ||.  .   |  |  .| ||   |  ||.       .|| |           .
gqrryiatqhplretladfwqmvwetgsghivmvnddqknkeadypfywpttes..gtgkygslsvttkti..ttkpdytitalil.tnnttappstrei

KHLALNNWPDYGVPSSPRA---VLRAIEVARDIRyRNPGQPIVVHCSAGVGRTGILVAVDIGIDMLLAGR--RVNLTSIVQHMREDRGGMLQTFPQYEFA
 |  .  | .   |        |. . ||..    ..   |..|||| | | ||..||.|||.      .   |.|  . . .|. | |.. ....|.| 
shyqftswkekttpnvalfvgfvvasrevskkye.qekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfi

FK
..
yq

subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 1430-1492 1e-12 42.6 In-house 229-291 (297) alignment
Range on Protein: 1430-1492
Range on HMM: 229-291/297.0
QPIVVHCSAGVGRTGILVAVDIGIDMLLAGRRVNLTSIVQHMREDRGGMLQTFPQYEFAFKAI
 ...|||||||||.|..|  |. ...|  .|  . ..|....|| |  ..||. |.|. ..|.
ayllvhcsaGvGrsGvvvlsdvilaklrkkripdvaailsilreqrarlvqtleqfellydav

0038934 (Phosphotyrosine protein) phosphatases II 1398-1491 4e-12 41.7 In-house 84-172 (194) alignment
Range on Protein: 1398-1491
Range on HMM: 84-172/194.0
LNNWPDYGVPSSPRAVLRAIEVARDIRYRNPGQPIVVHCSAGVGRTGILVAVdigidMLLAGRRVNLTSIVQHMREDRGGMLQTFPQYEFAFKA
   .||.|.. |   .|| .... ..  ..||. ..||| ||.||||.|||       |.  .. ..   ....|| |.|....  ..|  .| 
klpfpddgtvPsleillrfldlvdeflnedpggvvaVHCkaGlgRtGtlvaa.....YLiyrlgmsaeeAialfrekRpgaipnqdyleallkr

subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 1398-1493 4.4e-09 30.2 In-house 188-282 (302) alignment
Range on Protein: 1398-1493
Range on HMM: 188-282/302.0
LNNWPDYGVPSSpraVLRAIEVARDI--RYRNPGQPIVVHCSAGVGRTGILVAVDIGIDMLLAGRRVNLTSIVQHMREDRGGMLQTFPQYEFAFKAIG
|.||..  || .   . ..|. | ..  .  .  ...|.    |.|| |..... . .. | .|  .| . ||. .|..|  ..... || . . |. 
ltnWkqkkvpvk...yaeliktaakvfakkikadentvivSknGaGRagafltlavaveklqkgkepnikeivksiRsqRpravdslkQyvslyiall

PTEN_1 1400-1448 2.3e-08 29.1 In-house 101-149 (196) alignment
Range on Protein: 1400-1448
Range on HMM: 101-149/196.0
NWPDYGVPSSPRAVLRAIEVARDIRYRNPGQPIVVHCSAGVGRTGILVA
 ..|.|.||  .    . ...  .. ...|  ..||| ||.||.| .||
pieDhgapslselfdicksfiewllsdpngnvVlVHCkaGlgRsGtvva

subfamily_eak_pd Subfamily eak 1261-1471 3.4e-08 27.3 In-house 56-277 (332) alignment
Range on Protein: 1261-1471
Range on HMM: 56-277/332.0
NmdtVVKIDPLFENNVKVE-----NSDFINANWVRGFDGRQSYIATQGPKPNTIDHFWRMIIQHEVPLIIMATNLVEGDKIKCHRYWAlfdgIKGQEKdp
|   |||| |   ..|..      .  .|||  .   .  . || |  .. . .  ||.|...   | |..  . || .  |  .|.      |..|.  
n...vvkivpydrylvrltssqlnrlGyinaslaefsevGrkyiltGiasedkvfafwqmvleqkspaivqlledvelkleksdkyfp....dktree..

nllVTESGIRVTTEEVAKSRDFILRTFRLEWNDKEHFVKHLALNNWPDYGVPSSP-----RAVLRAIEVAR--------------DIRYRNPGQPIVVHC
   .    . |.. |  |   .  | . |.  .. | |.|  .  | .. .|        | |.. . |                   .  |    .. .
...lkfGildverkefvkrniletrllelskGnethrvlhykvfGwtettlpkyedflalrkvmkevGvlllivmksallsstlkkyihtppsfapiiqs

SAGVGRTGILVAVDIGIDMlLAGRRVNLTSIVQHM
. |  |.|..| .|. | . . ... || |. . .
arGsaraGvfvvidllirl.idnkkknlysvedli

subfamily_PTPDC1_pd Subfamily PTPDC1 1399-1486 1.5e-07 26.1 In-house 88-166 (182) alignment
Range on Protein: 1399-1486
Range on HMM: 88-166/182.0
NNWPDYGVPSsPRAVLRAIEVARDIRYRnpGqPIVVHCSAGVGRTGILVAVdigidMLLAGRRVNLTSIVQHMREDRGGMLQTFPQYE
  |.||||.|  . .|  . |.     .  |  . ||| || ||||.|.|.     .|.  .|..    .. .|. |   .||  | |
fgwkDygvas.leriLdivkvvafalqe..g.kvavhChaGlGrtGvliac.....ylvyakrltaekaiklvrskrpksiqtreqve

subfamily_Sponge-PTP-7_pd Subfamily Sponge-PTP-7 1432-1491 8.5e-07 23.3 In-house 1-60 (69) alignment
Range on Protein: 1432-1491
Range on HMM: 1-60/69.0
IVVHCSAGVGRTGILVAVDIGIDMLLAGRRVNLTSIVQHMREDRGGMLQTFPQYEFAFKA
.|||||.| |||| ..|. . .  . . . |..   ||.||  |  |.    .| |   |
mvvhcssgtgrtgtfiaimvemarikseklvdifnnvqymrkcrpmmvmneieyifihda

subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 1254-1328 1.6e-06 21.9 In-house 42-117 (347) alignment
Range on Protein: 1254-1328
Range on HMM: 42-117/347.0
RYKNIVPNMDTVVKIDPLFENNVKVENS-DFINANWVRGFDGRQSYIATQGPKPNTIDHFWRMIIQHEVPLIIMAT
| |.   . .| | . |   .| . ...  .|||  ..  . .. || || | |.|.  ||.|.    |  ..   
rskdvklidatrvvlspeksknsraddvetyinashikfdnaskeyiltqyplpdtvrdfwkmvsvtkvtqvvtif

subfamily_Sponge-PTP7_pd Subfamily Sponge-PTP7 1433-1492 1.6e-06 22.4 In-house 1-60 (69) alignment
Range on Protein: 1433-1492
Range on HMM: 1-60/69.0
VVHCSAGVGRTGILVAVDIGIDMLLAGRRVNLTSIVQHMREDRGGMLQTFPQYEFAFKAI
|||||.| |||| ..|. . .  . . . |..   ||.||  |  |.    .| |   |.
vvhcssGtGrtGtfiaimvemarikseklvdifnnvqymrkcrpmmvmneneymfihdal

IQ IQ calmodulin-binding motif 1918-1933 1.8e-06 16.9 Pfam-A 2-17 (21) alignment
Range on Protein: 1918-1933
Range on HMM: 2-17/21.0
AAAIRIQAAFRGYRAR
.|||.||||.|||.||
kaaikIQaawRgylaR

subfamily_PRL_pd Subfamily PRL 1401-1479 9.1e-06 19.8 In-house 61-134 (151) alignment
Range on Protein: 1401-1479
Range on HMM: 61-134/151.0
WP-DYGVPSSPRAVLRAIEVARDIRYRNPGQPIVVHCSAGVGRTGILVAVDigidMLLAGrrVNLTSIVQHMREDRGGML
.. | | . .   | . .|. ..   ..|.. . ||| ||.||. .|||.     .. ||  ..    |. .|| | | .
lafddGavPpeevveeWlellkekfkeepkstvavhcvaGlGraPvlvala....lieaG..mkyedavefirekrrgai