Gene Myosin-PTP-1 in Monosiga brevicollis

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily Myosin-PTP
Protein sequence
ID Type Fasta BLAST phosphatome Note
MbreP060_AA protein Get Run
MbreP060_AA_1241-1496 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
Myosin_head Myosin head (motor domain) 253-1019 1.2e-179 584.9 Pfam-A 2-689 (689) alignment 
Range on Protein: 253-1019
Range on HMM: 2-689/689.0
DNLARYNDITEDYIVGTLQLRYRDGLIYTAVGDILVAVNPYQEVGLYSDEWKAAYMFDSDISRRPHIFGIALRAFRAMANEGVDQSCVISGESGAGKTET
..||. . ..|. ..  |. || ..|||| .|..|..||||... .||.|  ..|.  .     |||| .| .|.|.| ... .||.|||||||||||| 
edlaaltqlsetsllenLkkrytgdliytysGlvlisvNpykklpiyseeiieeykgkkreelppHifalAdeAYrsmlrrkenqsivisGESgagkTea

AKLFLRHLLDLSGGNIQELLHRYDLMQFSINNLLEAFGNAQTRINRNSSRFGKYVELGFSRDNHALGVMLSTYLLEKSRVvhqscpshvmhnarlppntG
.|. ...|. .|. . .   ..   .  . | .|||||||.|  | |||||||..|. |  . .  |  ..|||||||||                    
tkkliqylasvssstekaeeeeleskilqanpileafgnaktlrnnnssrfGkfleiqfdasgsivGakietylLeksRv...................v

LQSEGERNFHIFYYLVEGLSDAERKQYHLDgTIRDFAYINGGVtpyerartgrQSDLAGMPAETplLYRELIDYMKLAGFSAIELEYIHQMLALVLLLGN
 |..|||||||||.|..|.|..|.....|. . ...||.. .           |... |.       ..|. . .|  |... | . | ..|| .| |||
sqekgeRnFhiFYqLlagasaeekeelkLk.daksYaylsqsg..........qlkvdgidDae..efketrkalkilglkeeeqreifkvlAaiLhlGn

IDFDRDSRGKGQRFMKLDVigpLEAVAALLGCTVSDVGHGLASTIMVTRGDTIVKENTQQDAKDARDAMAKALYGRLFFWVVNKVNLLLGLHDmSQVKRT
|.|  | ...   . . ..   ||..|.|||  |... . | .  . |. ....|  ... |.|||||.|||.| ||| |.|.|.|  |  .. .... .
ikfkedqkeeqavvedkee...lekiaellgvdveelekallkrriktgrevvtkalnkeqaedardaLakaiYsrLfdwivekiNealsake.dkaaav

IGVLDIFGFESLKVNSLEQMCINIANEQLQEFFNSHIFAWQQQELTEEGIDASFVSF-TDNSSLLNLFIGNPVGLLNLVDEQSRFPNADDQSLIDKLANQ
||||||.|||  . ||.||.|||.|||.||.||| |||   |.|. .|||. ..... .||.  ..|   .|.|.| |.||..|.|.|.|.|...|| ..
iGvlDiaGFeifeknsfeqlciNyanEkLqqffnehifkleqeeyeregieweeidygldnqavidLiekkpaGilsllDeecrlpkatdesflekllet

LSQHNTIFTKGK---KSKKLHFTIQHYAGPIDYDVTGWIEKNRDSLTPSVTSLLRESQNVLVRDLFSTSQTLFggltanepqalrdqrqenarelikvlr
 ..... |.| .   . .. .||..|||| ..|...|..|||.| |......||..|.. ||..||.  ..                             
feskhpkfskkrlskaraessftvkHyAgeVeYsaegflekNkdplsedlvellkssssslvaelfkeeelae...........................

rsfwnpskqekasenrrqvlRANGGGGGGRMQRLDSQpslPVSKTVKKASTTICASFKASLNDLVTKLSQTEPSFVRCIAPNHDQKPNDYVEAEVLRQLR
                      .     .....|.|.     ....||  .|. . ||.||. |...|..|.| ||||| ||...|...  .  || ||.
....................dfeeeeaaaesaklgsa...kgksgkkkkfetvgsqfkeslgelmktLrstnphfvrCikPneekkakkfdsklvleqlk

YTGVMETIRIRREGFAVRLFFDEFVARYRLLHYRFK---QGLAAEPVDACKQILSSFSEDPSEWQLGKSKVFLK
. ||.|.|||||.||. |. ||||. ||.||  .     . |  .  .||..||.. . | .|...||.|||..
clGvlegirirraGfpsriafdefaerykllaekelvklselvgdekkacekilkeleldkeeyrvGktkvFfr
0050432 (Phosphotyrosine protein) phosphatases II 1249-1496 4.5e-73 241.6 In-house 68-299 (308) alignment 
Range on Protein: 1249-1496
Range on HMM: 68-299/308.0
AAQLCRYKNIVPNMDTVVKIdplfennvKvENSDFINANWVRGF--DGRQSYIATQGPKPNTIDHFWRMIIQHEVPLIIMATNLVEGDKIKCHRYWALF-
   ..|||.|.|.  . ||.        . |.||.|||..|.|.  . .. .||||||.|||...||||. ...|..|.| |.||| ...||..|| |  
nkdkNrykdilpydhsRVkl........d.egsdYInAsyvdgyssklprkfIatqgPlpntvedFwrmvweqnvrvIvmLtklvengrekcaqYwplel

-DGIKGQekdpnllvteSGIRVTTEEVAKSRDFILRTFRLEW--NDKEHFVKHLALNNWPDYGVPSSPRAVLRAIEVARDIRyrnPGQPIVVHCSAGVGR
 .|..             ...||. .. .  |...||..|..  ......|.|.   ||||.|||.||...|. .| .|. .   || ||||||||||||
gggsley..........gkftvtllseevlddytvrtleltnlgdgesrtvthfhytnWpdhgvPpspeilldflelvrksl...pggpivVHCsaGvGR

TGILVAVDIGIDMLLAGRRVNLTSIVQHMREDRGGMLQTFPQYEFAFKAIGSFA
|| ..|.|. ...| ....|.. ..|...|| | || ||. ||.| ..|.  ..
tGtfialdllleqlekeggvdvfeavkklReqRpgmvqtpeqylflyralleyl
0051299 (Phosphotyrosine protein) phosphatases II 1249-1493 9.8e-72 237.1 In-house 49-283 (288) alignment 
Range on Protein: 1249-1493
Range on HMM: 49-283/288.0
AAQLCRYKNIVPNMDTVVKIDPLFEnnvkVENSDFINANWVRGFDGRQSYIATQGPKPNTIDHFWRMIIQHEVPLIIMATNLVEGDKIKCHRYWALfDGI
  . .||..|.|. .. ||. .| .    ||.||.|||....|..  . .||||||.|||...||||. ...|..|.| |.||| ...||..|| | .| 
nleknRysdilpydhsRVkLsvldg....vegsdYinAsyidgynlkrkfIatqgPlpntvedFWrmvweqnvrvIvmltklvelgrekcaqYwpl.ggs

KGQEKdpnllvtesgIRVTTEEVAKSRDFILRTFRLE------WNDKEHFVKHLALNNWPDYGVPSSPRAVLRAIEVARDIRYrNPGQPIVVHCSAGVGR
.  ..          |.||. .. .  |...||....      .......|.|.   ||||.|||.||...|. .. .|. .  ..| |.||||||||||
ltygd..........itvtllseevlddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpdspellldflrlvrkala.sgggpvvVHCsaGvgR

TGILVAVDIGIDMLLAGRRVNLTSIVQHMREDRGGMLQTFPQYEFAFKAIG
|| ..|.|. ...|.....|.. ..|...|| | || ||. ||.| ..|. 
tgtfialdllleqlekeggvdvleavkrlreqRpgmvqtpeqyrfvyeall
0046845 (Phosphotyrosine protein) phosphatases II 1250-1496 2.6e-71 235.6 In-house 29-274 (284) alignment 
Range on Protein: 1250-1496
Range on HMM: 29-274/284.0
AQLCRYKNIVPNMDTVVKIDPLFENnvkVENSDFINANWVRGF-----DGRQSYIATQGPKPNTIDHFWRMIIQHEVPLIIMATNLVEGDKIKCHRYWAL
  ..|||.|.|. .. ||...| ..   .|.||.|||..|.|.     . .. .||||||.|||...||||. ...|..|.| |.||| ...||..|| |
lsknRykdilpydhsRVklksldgd...ledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweqnvrvIVmltelvengrekcaqYwpl

FDGIKGQekdpnllvteSGIRVTTEEVAKSRDFILRTFRLEW---NDKEHFVKHLALNNWPDYGVPSSPRAVLRAIEVARDIRYR-NPGQPIVVHCSAGV
 .. .             ...||. .. .  |...||..|..   ......|.|.   .|||.|||.||. .|. .. .|... . ..| ||||||||||
egevlty..........gdftvtllseevkddytvrtleltnlgytgesrtvthfhytswpdhgvppspedlleflrlvrellenlpgggpivVHCsaGv

GRTGILVAVDIGIDMLLAGR---RVNLTSIVQHMREDRGGMLQTFPQYEFAFKAIGSFA
|||| ..|.|. ...| ...   .|.. ..|...|| | || ||. ||.| ..|.  ..
gRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyealleyl
DSPc_SM00195 1251-1494 9.4e-70 230.3 In-house 28-260 (263) alignment 
Range on Protein: 1251-1494
Range on HMM: 28-260/263.0
QLCRYKNIVPNMDTVVKIDPLFENnvkvENSDFINANWVRGFDGRQSYIATQGPKPNTIDHFWRMIIQHEVPLIIMATNLVEGDKIKCHRYWALFDgikg
.  |||||.|...| ||...  ..    |.||.||||...| . ...|||||||.|.|...||||.....|..|.| |. .| .|.||.|||        
sknRyknilpydhtrVklkkeekk....egsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlteeeengkekcdrywpees....

qekdpNLLVTESGIRVTTEEVAKSR-DFILRTFRLEWND--KEHFVKHLALNNWPDYGVPSSPRAVLRAIEVARDIRYRNpGQPIVVHCSAGVGRTGILV
     .   |   |.|.. || | . ..||||..|. ..  ....|...  .|||| |||.|.. ||. .....  . ..  .||||||||||||||..|
.....ggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkksksts.sgpivVhCsaGvgRtgtfv

AVDIGIDMLLAGRRVNLTSIVQHMREDRGGMLQTFPQYEFAFKAIGS
..|| .. | .. .|.. .||...|. | || ||. || |. .||  
tidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaile
PTPc_SM00194 1251-1494 9.4e-70 230.3 In-house 28-260 (263) alignment 
Range on Protein: 1251-1494
Range on HMM: 28-260/263.0
QLCRYKNIVPNMDTVVKIDPLFENnvkvENSDFINANWVRGFDGRQSYIATQGPKPNTIDHFWRMIIQHEVPLIIMATNLVEGDKIKCHRYWALFDgikg
.  |||||.|...| ||...  ..    |.||.||||...| . ...|||||||.|.|...||||.....|..|.| |. .| .|.||.|||        
sknRyknilpydhtrVklkkeekk....egsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlteeeengkekcdrywpees....

qekdpNLLVTESGIRVTTEEVAKSR-DFILRTFRLEWND--KEHFVKHLALNNWPDYGVPSSPRAVLRAIEVARDIRYRNpGQPIVVHCSAGVGRTGILV
     .   |   |.|.. || | . ..||||..|. ..  ....|...  .|||| |||.|.. ||. .....  . ..  .||||||||||||||..|
.....ggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkksksts.sgpivVhCsaGvgRtgtfv

AVDIGIDMLLAGRRVNLTSIVQHMREDRGGMLQTFPQYEFAFKAIGS
..|| .. | .. .|.. .||...|. | || ||. || |. .||  
tidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaile
0036941 (Phosphotyrosine protein) phosphatases II 1248-1496 2.9e-69 229.0 In-house 38-277 (297) alignment 
Range on Protein: 1248-1496
Range on HMM: 38-277/297.0
NAAQLCRYKNIVPNMDTVVKIdplfennvKVENSDFINANWVRGFDGRQSYIATQGPKPNTIDHFWRMIIQHEVPLIIMATNLVEGDKIKCHRYWALFDG
.  ...|||.|.|. .| ||.        . |.||.|||..| |.|  . .||||||.|||...||||. .. |. |.| |.||| ...||..|| |  |
enleknRykdilpydhtRVkl........ddegsdYinAsyvdgydlkrkfIatqgPlpntvedFWrmvweqnvtvIvmltelvelgrekcaqywpleeg

IKGQEKDpnllvtesgIRVTTEEVAK--SRDFILRTFRLEW--NDKEHFVKHLALNNWPDYGVPSSPRAVLRAIEVARDIRYRN-PGQPIVVHCSAGVGR
   . .|         ..||. .| .  . |..|||....   |.....|.|.   .|||.|||.||. .|. || .|...    .| |..|||||||||
esltygd.........ftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfielvrkvlkllpsggpvlVHCsaGvgR

TGILVAVDIGIDMLL---AGRRVNLTSIVQHMREDRGGMLQTFPQYEFAFKAIGSFA
.| ..|.|. ...|      ..|.. ..|...|| | |. ||. ||.|   |.  . 
sgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallell
0047943 (Phosphotyrosine protein) phosphatases II 1249-1492 6.8e-69 227.7 In-house 38-268 (273) alignment 
Range on Protein: 1249-1492
Range on HMM: 38-268/273.0
AAQLCRYKNIVPNMDTVVKIdplfennvKVENSDFINANWVRGFDGRQSYIATQGPKPNTIDHFWRMIIQHEVPLIIMATNLVEGDKIKCHRYWALFDG-
  ...|||.|.|. .. ||.        . ..||.|||..|.|..  . .||||||.|||...||||. .. |..|.| |.||| ...||..|| |  | 
nkdknrykdilpydhsrvkl........gdggsdyinAsyvdgynlkrkfiatqgPlpntvedfwrmvweqnvrviVmLtelvelgrekcaqYwplegge

-IKGQEKdpnllvtesgIRVTTEEVAKSRDFILRTFRLEW--NDKEHFVKHLALNNWPDYGVPSSPRAVLRAIEVARDIRYRN-PGQPIVVHCSAGVGRT
  .  .|          ..||. .. .  |...||..|..  ......|.|.   .|||.|||.|.  .|. ||..|...  .  . |.|||||||||||
lsltygk..........ftvtllseetkddytvrtleltnlgtgesrtvthfhytgwpdhgvppslesllefielvrkalealpsngpvvVHCsaGvgRt

GILVAVDIGIDMLLAGRRVNLTSIVQHMREDRGGMLQTFPQYEFAFKAI
| ..|.|. .|.| ....|.. ..|...|. | || ||. ||.|  .|.
gtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrflyeal
0040438 (Phosphotyrosine protein) phosphatases II 1251-1496 1.7e-68 226.6 In-house 45-276 (317) alignment 
Range on Protein: 1251-1496
Range on HMM: 45-276/317.0
QLCRYKNIVPNMDTVVKIDPLFEnnvkVENSDFINANWVRGFDGRQSYIATQGPKPNTIDHFWRMIIQHEVPLIIMATNLVEGDKIKCHRYWALfDGIKG
...||..|.|. .. ||. || .    ...||.|||..| |.. .. .||||||.|||...||||. .. | .|.| |.|.| ...||..|| | .. . 
dknrypdilpydhsRVkLsplgg....dldsdYInAsyvdgpnlkrkfIatqgPlpntvedFwrmvweqgvtvivmLteleelgrekcaqYwpl.getlt

QEkdpnllvtesGIRVTTEEVAKSRDFILRTFRLEW--NDKEHFVKHLALNNWPDYGVPSSPRAVLRAIEVARDIRYrNPGQPIVVHCSAGVGRTGILVA
 .          ...||. .. .  ...|||...|   ......|.|.   .|||.|||.||. .|. .| .|. .  .|| |..||||||||||| ..|
yg..........dftvtllseeelagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfleavreale.dpggpvlVHCsaGvgRtGtfia

VDIGIDMLLAGRRVNLTSIVQHMREDRGGMLQTFPQYEFAFKAIGSFA
... ...|  ...|.....|...|| |.|. ||. ||.|  .|.  . 
aylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalleyl
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 1235-1497 4.5e-67 220.9 In-house 4-265 (270) alignment 
Range on Protein: 1235-1497
Range on HMM: 4-265/270.0
LPLNLGNLADLPKNA--AQLCRYKNIVPNMDTVVKIDPLFENnvkvENSDFINANWVRGFDGRQ-SYIATQGPKPNTIDHFWRMIIQHEVPLIIMATNLV
|. .  .  |||. |  ..| ||..|.|.  | |....| |.    ... .||||.||||||.. .|||..||.|.|. .|||||....|. |.|.|.|.
ldkeetsesdlpeaargkklnRyadiLPsPatRvrleeleed....sataYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgle

EGDKIKCHRYWALfdgikgqEKDPNLLVTESGIRVTTEEVAKSRDFILRTFRLEWNDKEHFVKHLALNNWPDYGVPSSPR------AVLRAIEVARDIRY
|  . || |||.        |.. .. ...  |.|.... .|.. .||.  ||| . .|. . |   |.||| |||...        .|. ..  |  . 
EkgrkkCerYWpa.......epkekvkledgkikvlalseekeegyiltrlrleekgeerrlvHfwyntWpdhgvpreedsslstdqllkmlravrrsek

RN-PGQPIVVHCSAGVGRTGILVAVDIGIDMLLAGRRVNLTSIVQHMREDRGGMLQTFPQYEFAFKAIGSFAR
.   ..|..|||||||||||.|.|.||.. .|   ..|....|....|.||  ..|.  ||||..||.  .|.
eldkaePllvHcsaGvgRtGtlialDiavrlLeetkkvdvlaiieelRkdRmalvqhpeqyeflykavveyae
0039614 (Phosphotyrosine protein) phosphatases II 1251-1492 8.5e-67 221.0 In-house 58-285 (297) alignment 
Range on Protein: 1251-1492
Range on HMM: 58-285/297.0
QLCRYKNIVPNMDTVVKIDPLFENnvkVENSDFINANWVRGFDG-RQSYIATQGPKPNTIDHFWRMIIQHEVPLIIMATNLVEGDKiKCHRYWALFDGik
 ..|||.|.|. .. ||. |. .    ...||.|||..| |.|   . .|||||| |.|...||||. .. |. |.| |.||| .. ||..||    |  
dknrykdilpydhsrvklkpedgv...dldsdYinAsyvdgydlltrkfIatqgPlpetvedFwrmvweqgvtvivmLtklvelgr.kcaqywpeegg..

gqekdpnllvTESGIRVTTEEVAKSRDFILRTFRLEWNDKEHFVKHLALNNWPDYGVPSSPRAVLRAIEVARDIRYRN-PGQPIVVHCSAGVGRTGILVA
          |  ...||. .| .  ....||.... |.....|.|.   .|||.|||.|.. .|...| .|... .. .| |..||||||||||| ..|
..........tygdftvtllkvehldgytvrtlevtnngesrtvthfqytgwpdhgvppslellleflelvrealaelpkggpvlVHCsaGvgRtGtfia

VDIGIDMLLAGRRVNLTSIVQHMREDRGGMLQTFPQYEFAFKAI
 .. ...|  ...|.. ..|...|| |.|. ||. ||.| ..|.
aylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydal
0045450 (Phosphotyrosine protein) phosphatases II 1251-1491 2.2e-66 220.0 In-house 57-299 (307) alignment 
Range on Protein: 1251-1491
Range on HMM: 57-299/307.0
QLCRYKNIVPNMDTVVKIDPLFENnvkVENSDFINANWV--------RGFDGRQSYIATQGPKPNTIDHFWRMIIQHEVPLIIMATNLVEGDKIKCHRYW
 ..|||.|.|. .| ||. .| ..   .|.||.|||..|         |.|  . .||||||.|.|...||||. .. | .|.| |.||| ...||..||
dknrykdilpydhtRVklssldgs...ledsdYiNAsyvrvpllllldgydlkrkfIatqgPlpetvedFwrmlweqgvtvivmltelvelgrekcaqyw

ALFdGIKGQEKDpnllvtesgIRVTTEEVAKSRDFILRTFRLE---WNDKEHFVKHLALNNWPDYGVPSSPRAVLRAIEVARDIRYRN-PGQPIVVHCSA
 .  | . . ..         ..||. .. .  ....||....    ......|.|.   .|||.|||.|.  .|. || .|... .. .| |..|||||
Pde.geeltygn.........ftvtllseehldgytvrtlevtdldgtgesrtvthfhytgwpdhgvppsfeelldfieevrkaleelpkggpvlVHCsa

GVGRTGILVAVDIGIDMLLAGRR---VNLTSIVQHMREDRGGMLQTFPQYEFAFKA
|||||| ..| .. ...| ..     |.| ..|...|| |.|. |.. ||.|  .|
GvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyea
subfamily_PTPRD_pd Subfamily PTPRD 1253-1493 8.2e-65 214.5 In-house 52-278 (564) alignment 
Range on Protein: 1253-1493
Range on HMM: 52-278/564.0
CRYKNIVPNMDTVVKIDPLfennVKVENSDFINANWVRGFDGRQSYIATQGPKPNTIDHFWRMIIQHEVPLIIMATNLVEGDKIKCHRYWAlfdgikgqE
 ||.|||.   . |.. ..     ..|.||.|||... |.. |..|||||||...||. ||||. ....  |.| |.|.| .| |||.||         |
NRyanivaYdhsRVvLskv....egdegsDYINAsfidgyrkrkayIAtqgPlaetiedFWRmvweqnsstiVmltkleEkgkvkchkYWP........e

KdpNlLVTESGIRVTTEEVAKSRDFILRTFRL--EWNDKEHFVKHLALNNWPDYGVPSSPRAVLRAIEVARDIRyRNPGQPIVVHCSAGVGRTGILVAVD
|  .   |  .. || ||  .  |...|||.|  . ... . |..    .||| ||| |....|. |.  |... ..  .||||||||||||||. ...|
k..g.tetygeltVtleeeeeladyeirtfklkkkkssesreVrqFhFtsWPdhgvpesatslLdlirkvraln.epdagPivVhCSaGVGRTGtfivid

IGIDMLLAGRRVNLTSIVQHMREDRGGMLQTFPQYEFAFKAIG
. .. . . . |.. ..|...|..|  | ||  || | ..|| 
amlerikeektvDiyqyvkalrkqRnamVqteeQYiFiheail
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 1232-1497 1.4e-64 212.9 In-house 11-269 (274) alignment 
Range on Protein: 1232-1497
Range on HMM: 11-269/274.0
FDALPLNL-GNLADLPkNAAQLCRYKNIVPNMDTVVKidpLFENNVKVENSDFINANWVRGFDGR-QSYIATQGPKPNTIDHFWRMIIQHEVPLIIMATN
|  ||||   .  |..  ...  |||.|.||  . |    | ..... |.|..||||...|.|.. . |.||||| |||.. ||||| |.||..|.| |.
flelPlnfdqeeldvf.gsqtknryktilPnensrvl...lesessededssyinanyikGydeeskayvatqGPlpntvadfWrmiyqeevqvivmltk

LVEGDKIKCHRYWAlfdgikgQEKDPNLLVTESGIRVTTEEVAKSRDFILRTFRLEWNDKEHFVKHLALNNWPDYGVPSSPRAVLRAIEVARDIRYRNPG
| | .. ||..|.        ...| ..  .  .. ...|.. .  |. .|.. |.   .|. |||    .|||  .| .....|. ..  .. | ..  
lkeaneqkCavyfP.......daedyeiserygdveikvekiverndysvrklvlkylerersvkhywytdWPdhksPddantlldlvleveesreeena

Q--PIVVHCSAGVGRTGILVAVDIGIDMLLAGRRVNLTSIVQHMREDRGGMLQTFPQYEFAFKAIGSFAR
.  |.|||||||.||||. .|..|..  | .   |.. .|| ..| |||||.||  |||. ..|.  ...
klapvvvhCsaGiGrtGcfiaisiavrqlreeivvdvlkivcnlrldrGGmvqtseqyelihralclylk
0043336 (Phosphotyrosine protein) phosphatases II 1250-1491 2.9e-64 212.6 In-house 46-272 (278) alignment 
Range on Protein: 1250-1491
Range on HMM: 46-272/278.0
AQLCRYKNIVPNMDTVVKIDPlfenNVKVENSDFINANWVRGFDGRQSYIATQGPKPNTIDHFWRMIIQHEVPLIIMATNLVEGDKIKCHRYWAlfdgiK
 ...|||.|.|.  . ||...      ....||.|||..| |..  . .|||||| |.|...||||. .. |. |.| |.||| ...||..||      .
kdknrykdilpydhsrvklsl....lggdldsdYinAsyvdgynvprkfiatqgPlpetvedFwrmvwelgvttivmLtelvelgrvkcaqYwp.....g

---GQEKdpnllvtesgIRVTTEEVAKSRDFILRTFRLE--WNDKEHFVKHLALNNWPDYGVPSSPRAVLRAIEVARDIRYrNPGQPIVVHCSAGVGRTG
     ..          ..||. .. .  |...||....   ......| |.   .|||.|||.|.  .|. ....|...  ... |..|||||||||||
gsltygd..........ftvtllkeehlddytvrtlevtnlgdgesrtvthyhylgwpdhgvpeslsllldflkavreale.dsngpvlVHCsaGvgRTG

ILVAVDIGIDMLLAGRRVNLTSIVQHMREDRGGMLQTFPQYEFAFKA
 ..|... ...|  ...|.| ..|...|| |.|..||. ||.| ..|
tfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflyea
subfamily_PTPN12_pd Subfamily PTPN12 1251-1495 3.3e-64 211.5 In-house 42-276 (290) alignment 
Range on Protein: 1251-1495
Range on HMM: 42-276/290.0
QLCRYKNIVPNMDTVVKIDPLFENNvkveNSDFINANWVRGFDGRQSYIATQGPKPNTIDHFWRMIIQHEVPLIIMATNLVEGDKIKCHRYWAlfdgikg
.  |||.|.|   . |..    |..    .||.||||...| .|...|||.||| |.|.| |||||....| ...|| ..|| .|.||.|||.       
kknrykDilPydksrvelskieeee....gsdYinanfikgvegkleyiaaqgPLpktlddfWrmiweknveivvmaCrevelgkkkCerYWp.......

QEKDPNLLVTESGIRVTTEEvAKSRDFILRTFRLEWNDKEHFVKHLALNNWPDYGVPSSPRAVLRAIEVARDIRYrNPGQPIVVHCSAGVGRTGILVAVD
.|.. .| . |  . ...|. | . ||..||...| ..... |. .  ..||| |||||.  .|. || .|...  .  .|.||||||||||||...|.|
eegeeelefgefevtleeek.avdddflirtLkveaqkesrkvyqfhYtaWPDhgvPssaksllelielvrelqe.sedaPlvvhCsaGvGrtGtiiaid

IGIDMLLAGRR---VNLTSIVQHMREDRGGMLQTFPQYEFAFKAIGSF
.  ..| |..    ... ..|...|..|  . ||  |||. .||. ..
yvrellkaekipeeldvfdlvlelrkqraalvqtkeqyelvykavael
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 1249-1492 4e-63 208.1 In-house 41-272 (281) alignment 
Range on Protein: 1249-1492
Range on HMM: 41-272/281.0
AAQLCRYKNIVPNMDTVVKIDPLFENNvkveNSDFINANWVRGFDGRQSYIATQGPKPNTIDHFWRMIIQHEVPLIIMATNLVEGDKIKCHRYWAlfDGI
  .  ||.|||    | ||. |  ||.    |.|.||||.| |..| . ||||||| |.....||.|.....| .|.| |. .|..|.||||||   |. 
nvlknrYsnivaYDatrvkvtpneenk....ntDYinanfvpgykgekeyiatqgPvPaslvafWqmvweqkvsaivmvtreieagklkChrYWP..ddn

KgqekdpnlLVTESGIRVTTEEVAKSRDFILRTFRLEWN-DKEHFVKHLALNNWPDYGVPSSPRAVLRAIEVARDIRYRNPGQPIVVHCSAGVGRTGILV
.         .. . ..|.... .... .| |.|.|| .  ..  |..||  .||| |||......|   .  . .. ..  .|.|.||||||||||  .
s........elkygdvtvkstaeeekatyierkfkleresgetreveqlaytaWPdhGvPattkellefrkevlkltekktkaplvihCsaGvGrtGtyi

AVDIGIDMLLAG-RRVNLTSIVQHMREDRGGMLQTFPQYEFAFKAI
|.|  .. . |  ...... .|...|..|  |.||  |||| .||.
alDrlvkaveaeleeldvkavvaelrkernlmvqtvvqyefvykav
Y_phosphatase Protein-tyrosine phosphatase 1252-1492 7.7e-63 207.4 Pfam-A 4-233 (235) alignment 
Range on Protein: 1252-1492
Range on HMM: 4-233/235.0
LCRYKNIVPNMDTVVKIdplfenNVKVENSDFINANWVRGFDGRQSYIATQGPKPNTIDHFWRMIIQHEVPLIIMATNLVEGDKIKCHRYWAlfdgikgq
 .|||.|.|  .| ||.      . . ..||.||||.|.|..  ...|||||| ..||..||||..|..| .|.| |.|.| .. ||..||         
knRykdilpydktrvkl......kgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwp........

eKDPNLLVTESGIRVTTE-EVA-KSRDFILRTFRLEWNDKE---HFVKHLALNNWPDYGVPSSPRAVLRAIEVARDIRyRNPGQPIVVHCSAGVGRTGIL
 .. .  .|   |.|... ..  .. ...||...|. ...|   . ||.| ..||||.|||.||...|. |.  .  . ..  .|.||||||||||||..
.eeeeesltygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkveksk.eaksgpvvVhCsaGvgRtgtf

VAVDIGIDMLLAGRRVNLTSIVQHMREDRGGMLQTFPQYEFAFKAI
||.|| ...| |.. |.. .||...|. | || |.. ||.|  |||
valdilleqleaeeevdvlqivkelRkqRpgmvqsleqYiflykai
Y_phosphatase Protein-tyrosine phosphatase 1252-1492 7.7e-63 207.4 In-house 4-233 (235) alignment 
Range on Protein: 1252-1492
Range on HMM: 4-233/235.0
LCRYKNIVPNMDTVVKIdplfenNVKVENSDFINANWVRGFDGRQSYIATQGPKPNTIDHFWRMIIQHEVPLIIMATNLVEGDKIKCHRYWAlfdgikgq
 .|||.|.|  .| ||.      . . ..||.||||.|.|..  ...|||||| ..||..||||..|..| .|.| |.|.| .. ||..||         
knRykdilpydktrvkl......kgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwp........

eKDPNLLVTESGIRVTTE-EVA-KSRDFILRTFRLEWNDKE---HFVKHLALNNWPDYGVPSSPRAVLRAIEVARDIRyRNPGQPIVVHCSAGVGRTGIL
 .. .  .|   |.|... ..  .. ...||...|. ...|   . ||.| ..||||.|||.||...|. |.  .  . ..  .|.||||||||||||..
.eeeeesltygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkveksk.eaksgpvvVhCsaGvgRtgtf

VAVDIGIDMLLAGRRVNLTSIVQHMREDRGGMLQTFPQYEFAFKAI
||.|| ...| |.. |.. .||...|. | || |.. ||.|  |||
valdilleqleaeeevdvlqivkelRkqRpgmvqsleqYiflykai
0045098 (Phosphotyrosine protein) phosphatases II 1251-1492 2e-62 206.4 In-house 35-268 (278) alignment 
Range on Protein: 1251-1492
Range on HMM: 35-268/278.0
QLCRYKNIVPNMDTVVKidplfennvkvensDFINANWVRGFdgRQSYIATQGPKPNTIDHFWRMIIQHEVPLIIMATNLVEGDKIKCHRYWAlFDGIKG
 ..|||.|.|.  . ||              |.|||....|.  .. .||||||.|.|...||||. .. .. |.|.|.|||....||..||   .| . 
dknRykdilpydhsrVk..............dYINAsyidgy..pkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrekcaqywp.eggslt

QekdpnllvteSGIRVTTEEVAKSRDFILRTFRLE------WNDKEHFVKHLALNNWPDYGVPSSP--RAVLRAIEVARDIRY------------RNPGQ
            ...||....    |..|||....       ......|.|| . .|||.||||.|  . .|...|  |. .              ..| 
y..........gdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsgg

PIVVHCSAGVGRTGILVAVDIGIDMLlaGRRVNLTSIVQHMREDRGG-MLQTFPQYEFAFKAI
|..||||||||||| |||... ...|  ...|.| ..|...|. |.| ..|.. ||.| ....
pvlVHCsaGvgRtGtlvaaylmlell..eggvdlleavkelrsqRpglavqnleqyrflyefl
subfamily_PTPRB_pd Subfamily PTPRB 1243-1494 9.6e-62 203.6 In-house 46-283 (293) alignment 
Range on Protein: 1243-1494
Range on HMM: 46-283/293.0
ADLPKNAAQlCRYKNIVPNMDTVVKIDPLFENnvkvENSDFINANWVRGFDGRQSYIATQGPKPNTIDHFWRMIIQHEVPLIIMATNLVEGDKIKCHRYW
|.|..|.|.  ||.||.|   . ||. .| ..    ..||.||||...|.  .. .|||||| |.|.|.||||. ....  |.| |.|||. |.||..||
aelavnrak.nrytnilpydhsrvkLaalkde....sgsDYinanyipgynsprefiatqGPlpetvddfWrmvwekkssiivmltqlvekgkvkCeeYW

ALFdgikgqekdpNLLVTESGIRVTTEEVAKSRDFILRTFRLEWNDKEHFVKHLALNNWPDYGVPSSPRAVLRAIEVARDIR-YRNPGQPIVVHCSAGVG
             .  |.   |.||  .  . .|...|....| ...|. |...    |||.|||......|. ..  |.     .  .|||||||||||
Pad..........eepvlyGdikvtlvaeeeledwvirelkiekekeerkvrqyhftsWpdhgvPektktlldfvrtvreaiektaskrPivvhCsaGvG

RTGILVAVDIGIDMLLAGRRVNLTSIVQHMREDRGGMLQTFPQYEFAFKAIGS
|||...|.|  .. .     |....||...||.|  ..||  || |  ... .
RtGtfialdrllqaieeedyvdifgivaelReeRnllvqtekqYifihqcvld
0040439 (Phosphotyrosine protein) phosphatases II 1251-1491 3.9e-61 202.1 In-house 13-241 (249) alignment 
Range on Protein: 1251-1491
Range on HMM: 13-241/249.0
QLCRYKNIVPNMDTVVKIDPLFEnnvkVENSDFINANWVRGFDGRQSYIATQGPKPNTIDHFWRMIIQHEVPLIIMATNLVEGDKIKCHRYWALfDGIKG
 ..||..|.|.  . ||. .| .    .. ||.|||... |..  . .|||||| |.|...||||. .. .  |.|.|.||| ...||..|| | .| . 
dknrypdilpydhsrvklsilpg....lflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywpl.ggsle

QekdpnllvteSGIRVTTEEVAKSRDFILRTFRLE--WNDKEHFVKHLALNNWPDYGVPSSPRAVLRAIEVARDIRYRN-PGQPIVVHCSAGVGRTGILV
            ...||. .| .. |...||..|.   ..... |.|.   .|||.|||.|.  .|. || .|... .. .| |..|||||||||||...
y..........gdftvtllsvevkddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfi

AVDIGIDMLLAGRRVNLTSIVQHMREDRGGMLQTFPQYEFAFKA
| .. ...|   ..|.| ..|...|. |.|. |.. ||.|  .|
aaylmleqlekelgvdleeavkllrsqRpgavqnpeqyrflyea
0042113 (Phosphotyrosine protein) phosphatases II 1251-1491 6.6e-61 201.1 In-house 11-238 (245) alignment 
Range on Protein: 1251-1491
Range on HMM: 11-238/245.0
QLCRYKNIVPNMDTVVKIDPLFEnnvkVENSDFINANWVRGFDGRQSYIATQGPKPNTIDHFWRMIIQHEVPLIIMATNLVEGDKIKCHRYWALfDGIKG
...||..|.|. .| ||. |  .     . ||.|||..| |..  . .|||||| |.|...||||. .. .  |.| |...| ...||..|| | .... 
dknrysdilpydhtrvklspdgg....dldsdyinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywpl.geslt

QEKdpnllvtesgIRVTTEEVAKSRDFILRTFRLE--WNDKEHFVKHLALNNWPDYGVPSSPRAVLRAIEVARDIRYRNPGQPIVVHCSAGVGRTGILVA
 ..          ..||. .. .  |...||....   .|....| |.   .|||.|||.... .|...| .|... .... |..||||||||||| ..|
ygd..........ftvtllseehlddytvrtlevtnlgddesrevihyhylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfia

VDIGIDMLLAGRRVNLTSIVQHMREDRGGMLQTFPQYEFAFKA
... ...| . ..|.| ..|...|. |.|. ||. ||.|  .|
aylmleqlekelgvsleeavkelrsqRpgavqtpsqyrflyea
0037934 (Phosphotyrosine protein) phosphatases II 1252-1491 4.8e-57 188.6 In-house 13-237 (243) alignment 
Range on Protein: 1252-1491
Range on HMM: 13-237/243.0
LCRYKNIVPNMDTVVKIdplfennvkvENSDFINANWVRGFDgRqsYIATQGPKPNTIDH----FWRMIIQHEVPLIIMATNLVEGDKIKCHRYWAlfdg
 .||..|.|. .. ||.          |.||.||||...... |  .|||||| |.|...    ||||. .. .  |.| |.||| ...||..||     
knrysdilpydhsrvkl..........egsdyinanliyvtp.r..liatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywp....

ikgqekdP-NllvTESGIRVTTEEVAKSRDFILRTFRLEW---NDKEHFVKHLALNNWPDYGVPSSPRAVLRAIEVARDIRYR-------NPGQPIVVHC
             |  ...||. ..    |...||..||.   .| ...| |.   .|||.|||.||  .|. .. .|..  .       ..| |..|||
.......gev...tygdftvtllseehlddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHC

SAGVGRTGILVAVDIGIDMLlagrRVNLTSIVQHMREDRGG-MLQTFPQYEFAFKA
|||||||| |.| .. ...|    .|.| ..|...|| |.| . ||. ||.|  .|
saGvgRtGtliaaylmllll....gvdleeavkllreqRpgkavqtpsqyrflyea
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 1253-1493 6.5e-56 184.7 In-house 50-277 (318) alignment 
Range on Protein: 1253-1493
Range on HMM: 50-277/318.0
CRYKNIVPNMDTVVKIDPLfennVKVENSDFINANWVRGFDGRQSYIATQGPKPNTIDHFWRMIIQHEVPLIIMATNLVEGDKIKCHRYWAlfdgikgqE
 || ||..  .| ||...|    ...|.||.||||.. |.  ...|||.|.| |.||. ||||. . .  .|.| |...|  |.|.||||         .
nryanilaydhtrvkLqml....egeegsDyinanyidGyrrkkayiaaqaPlpetieDfWrmvWeqnsavivmltqeeergkakvhryWP........s

KDPNLLvteSGIRVTTEEVAKSRDFILRTFRLEWND--KEHFVKHLALNNWPDYGVPSSPRAVLRAIEVARDIRYRNPGQPIVVHCSAGVGRTGILVAVD
|... .     ..|. .|  .. |..||.|... ..  ..  |.     .||| |||.|.  .|  .  .. .  ..  .||||||||||||||. .|||
kgsrsy...gklvvelkeevelsdyvlrefkvtrteeeesrqvrqyhytsWpdegvpesgaslldlvrqvskaqqksgagpivvhCsaGvGrtGvfiavd

IGIDMLLAGRRVNLTSIVQHMREDRGGMLQTFPQYEFAFKAIG
| .. . |   |..  .|...|| |  | ||  |||| .... 
illerikaealvDvfqtvkqlreqrnlmvqtedqyefiydvll
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 1249-1492 1.4e-54 180.3 In-house 46-279 (305) alignment 
Range on Protein: 1249-1492
Range on HMM: 46-279/305.0
AAQLCRYKNIVPNMDTVVKIDPLFENNvkveNSDFINANWVRGFDGRQSYIATQGPKPNTIDHFWRMIIQHEVPLIIMATNLVEGDKIKCHRYWAlfdGI
 ..  |.|.|..  |  ... .  ...    .||.|||..| |......||..||| .||.. |||.|..  |  |.| |.||||.| ||..||.   . 
nkaknrlkeitlldddriiltekesld....dsdyinasyvdgykrkkkyivaqgPlkntvadfWrliveekvstivmltklveggkdkCrqYWp...es

KGQEKDpnLlvteSGIRVTTEEVAKSRDFILRTFRLEW---NDKEHFVKHLALNNWPDYGVPSSPRAVLRAIEVARDIRYRNPGQPIVVHCSAGVGRTGI
|...|.  .      . |. .. ..  |.| | ...     ..... | .. | .||| ||| .. ..|. |.  .  . .. |.|..|||||||||||.
ktekke..f....gefsvelksektasdyieRklkisiededkesrtvlqyqltdWPdhGvpqfatsllslikrvqkdqkkdkgvpllVhCsagvgRtGv

LVAVDIGIDMLLAGRRVNLTSIVQHMREDRGGMLQTFPQYEFAFKAI
 .|||| .. | .   |..  .....|. | .|.||  || | . |.
fiavdialerlkkEevvdvfevlkqlRskrmkmvqtldqYvflhdal
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 1242-1492 2.6e-54 179.2 In-house 41-275 (288) alignment 
Range on Protein: 1242-1492
Range on HMM: 41-275/288.0
LADLPKNAAQlCRYKNIVPNMDTVVKIDPLfennVKVENSDFINANWVRGFDGRQSYIATQGPKPNTIDHFWRMIIQHEVPLIIMATNLVEGDKIKCHRY
 . |..|| .  ||.||.|   . ||.. |     .....|.|||... | .... ||||||| ..|...||... ....  |.| |.||||.| ||..|
agrlavnakk.nRyrnilpyDekrvklkkl....eeeagaDYinasyidgekkkkkyiatqgPladtvndfWelvyenktstivmltelveggktkCeeY

WAlfdgikgQEKDPNLLvteSGIRVTTEEVAKSRDFILRTFRLEWNDKEHFVKHLALNNWPDYGVPSSPRAVLRAIEVARDIRYRNpGQPIVVHCSAGVG
|        ....|..      . ||  |. .  ||.||.. || . .|  .....   ||| ||| | . .|  ..        .  .||.||||||||
WP.......dadkpkny...GsvtvtlveskeledfvlrklllekkkteleitqyqylaWpdhgvPeskapllellrqvkvanqad.tgpiivhCsaGvG

RTGILVAVDIGIDMLLAGRRVNLTSIVQHMREDRGGMLQTFPQYEFAFKAI
|||. .|.|  ||.. .   ......|...|. |  . ||  |||| ....
rtgtFialdalidaveeedyiDvagtvaklRkqRallvqtlkqYefiyevl
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 1243-1497 3.7e-53 175.7 In-house 43-284 (319) alignment 
Range on Protein: 1243-1497
Range on HMM: 43-284/319.0
ADLPKNAAQlCRYKNIVPNMDTVVKIDPLFEnnvkVENSDFINANWVRGFDGRQSYIATQGPKPNTIDHFWRMIIQHEVPLIIMATNLVEGDKIKCHRYW
|. ..|  .  ||.||..   | |.. .| .    ||.||.|||... |.. |. .||||.|. |||. ||||. ..|.  ..| |.|||  |.|...||
askeenkkk.nryqnilaydrtrvvlseldg....vegsdyinasfidgyqerekfiatqaPlentiedfWrmvWeeessivvmltklveklkvklkkyw

AlfdgikgqEKDpnlLVTESGIRVTTEEVAKSRDFILRTFRLEWNDKEH---FVKHLALNNWPDYGVPSSPRAVLRAIEVARDIRYRNPGQPIVVHCSAG
         |..    ..   . || ||  .  |.| | . |. .  |     |||   ..||| .|| . ...|  ..  |  | ..  .|||||||||
p........een...feeyGrlivtleeeeeledyiirklklnkkssevetRevkhfqyteWpdhdvPekatslldllkrirksrektqsgPivvhCsaG

VGRTGILVAVDIGIDMLLAGRRVNLTSIVQHMREDRGGMLQTFPQYEFAFKAIGSFAR
|||||  ...|. .. .     ... |.|...|  |  | |.  ||.| ..|.  .. 
vGRtGtfivldamlervkeegvlDvfstvsrlRtqRnimvqrpeqYkfiyealleave
subfamily_Ptp69D_pd Subfamily Ptp69D 1252-1495 7.8e-53 174.6 In-house 51-285 (307) alignment 
Range on Protein: 1252-1495
Range on HMM: 51-285/307.0
LCRYKNIVPNMDTVVKIDPLFENnvkvENSDFINANWVRGFDGRQSYIATQGPKPNTIDHFWRMIIQHEVPLIIMATNLVEGDKIKCHRYWALFdgikgQ
  ||..|..  .| ||. ..  .    |.||.|||....|.. ....|| |.|  .||. ||||| . || ||.| .|| | .. ||..||.       .
knRyedikafDktRvkLkkingk....edsdYinasfikgykekkkfiaaqdPveatigDfWRmiaeqevtlivmlsnlteknrkkcakYWpie.....d

----EkdpnllvtesGIRVTTEEVAKSRDFILRTFRLEWND-------KEHFVKHLALNNWPDYGVPSSPRAVLRAIEVARDIRYRNpGQPIVVHCSAGV
    .           | |.. .  |  |.| |.. .  ..       ... |     ..|.|. || ..|..|. || .|..   |   ||||||||||
evqyg..........dilvklvseekhsdyiiReldvskkkeesgevedsrkvvqyhytgWkDskvPevargllklieqvrelykln.rsPivvhCsaGv

GRTGILVAVDIGIDMLLAGRRVNLTSIVQHMREDRGGMLQTFPQYEFAFKAIGSF
||.||.||.|. .. | |  .|..  .|...|..|  ..| . ||.| ..|.  .
grsgifvaldsllqqlkaedkvdifetvkdLrsqRnllvqsleqYvflyralldy
subfamily_PTPRA_pd Subfamily PTPRA 1249-1500 4.2e-52 172.1 In-house 58-298 (330) alignment 
Range on Protein: 1249-1500
Range on HMM: 58-298/330.0
AAQLCRYKNIVPNMDTVVKIDPLfennVKVENSDFINANWVRGFDGRQSYIATQGPKPNTIDHFWRMIIQHEVPLIIMATNLVEGDKIKCHRYWAlfdgI
  .  |. ||.|.  . | . ..      ||.||.||| .. |.  ....||.|||| .|.. ||||| ...   |.| |.| | .. ||..||      
nkeknrvvnilPydfsrvilsvk....eGveesdyinasfidGykekdkfiaaqGPkeetvedfwrmiweqksativmltelkerkeekcaqywP....d

KGqekdpnlLVTESGIRVTTEEVAKSRDFILRTFRLE------WNDKEHFVKHLALNNWPDYGVPSSPRAVLRAIEVARDIRYRNPGqPIVVHCSAGVGR
.|       |||   |||. |..  . |. .| | ..       ..|.  |. . .. ||| |||. |. .|. ..  . .. .. | ||||||||||||
eG.......lvtyGnirvevedetvlvdytvrkflvqqlpdatrekksrlvrqfhftswPdvGvPfepiGmlkllkkvkklnqqsag.pivvhcsaGvGr

TGILVAVDIGIDMLLAGRRVNLTSIVQHMREDRGGMLQTFPQYEFAFKAIGSFArLYG
|| ....|  .... | |.|..  .|...|  |  |.||  |||| .|..  .  |||
tGtfivldavlervkaerkvdvfefvkrlrlqrpqmvqtdeqyefiykvlleyy.lyg
subfamily_PTPN13_pd Subfamily PTPN13 1250-1492 4.6e-52 172.0 In-house 38-265 (273) alignment 
Range on Protein: 1250-1492
Range on HMM: 38-265/273.0
AQLCRYKNIVPNMDTVVKIDplfennvkvENSDFINANWVRGFDG--RQSYIATQGPKPNTIDHFWRMIIQHEVPLIIMATNLVEGDKIKCHRYWAlfdg
 .  ||.|..|  .| ||..         ... .|||....   |  . .|||.||| |.|.. ||.|. . .. .|.| |. .|..|.||||||     
kdknryrnvlPydetrvklg.........deggyinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweqkaeviamvtlekekgkvkchrywP....

ikgQEKDPNlLVTESGIRVTTEEVAKSRDFILRTFRLEWND--KEHFVKHLALNNWPDYGVPSSPRAVLRAIEVARDIRYrnPGQPIVVHCSAGVGRTGI
   ..|. . |. .. ..|. ..| |  .| .|.. .. ..  . . | || . .|||.|||||.  .|. .   | ..      |||||||||.||.|.
...esknkk.lkvsnrlevellkvqkldgfvvralavkdsesgesrevahlnfvkwPdhgvPssaaellqfvaevrrlqt..dagPivvhcsaGiGrsGt

LVAVDIGIDMLLAGRRVNLTSIVQHMREDRGGMLQTFPQYEFAFKAI
|...|. ....   . .... ||...|| | |..||  || | .|||
litidvvlglierdkefdvkeivrklreqrqgvvqtkdqyifvykai
subfamily_PTPN9_pd Subfamily PTPN9 1253-1497 9.2e-52 170.9 In-house 46-291 (297) alignment 
Range on Protein: 1253-1497
Range on HMM: 46-291/297.0
CRYKNIVPNMDTVVKIDPLFENnvkvENSDFINANWVRGFDGRQSYIATQGPKPNTIDHFWRMIIQHEVPLIIMATNLVEGDKIKCHRYWALFDGIKGQe
 ||....   .| |..  . |.    |.||.||||.| |.  ....|||||| ..|.. ||||. ..||  |.|.| .||  ..|| .|| | ..   . 
nrytdvlcydetrvvlakvded....easdyinanfvdGykqkkafiatqGplkktvsdfWrmvWeqevlvivmttrvvergrlkcgqyWpleeessae.

kdpnllvtESGIRVTTEEVAKSRDFILRTFRLE--WNDKEHFVKHLALNNWPDYGVPSSPRAVLRAIEVARDI------------RYRNPGQPIVVHCSA
         . ..|.. || ...|.  |.. ..   ....  | |  .  |||||||||  ..|  .|..|.             ...  | ||||||||
........fgdlsvsnveveeeedykvrvleiknvkteesrkvthfqflsWPdyGvPssaaslldvlekvrekqalavkelgdewkghpsgPPivvhcsa

GVGRTGILVAVDIGIDMLLAGRRVNLTSIVQHMREDRGGMLQTFPQYEFAFKAIGSFAR
|.|||| ....|| .. |     |...  |...|. |  ..||  |||| ..|.  .| 
GiGrtGtfitldiclsrleevgtvdvvetvkllrtqrafsiqtpeqyefcylavleyal
subfamily_PTPN6_pd Subfamily PTPN6 1253-1496 1.2e-51 170.6 In-house 58-297 (306) alignment 
Range on Protein: 1253-1496
Range on HMM: 58-297/306.0
CRYKNIVPNMDTVVKIDplfenNVKVENSDFINANWVR--GFDGRQSYIATQGPKPNTIDHFWRMIIQHEVPLIIMATNLVEGDKIKCHRYWAlfdgikg
 |||||.|  .|.|..      . .| .||.|||| ..    . ..|||||||  ..|.  ||||. | .  .|.|.|. ||  | || |||        
nryknilPfDhtrvilk.....epsvpgsdyinanyikkevkgsdksyiatqgclettvsdFWrmvwqensrvivmttkevErgkekCarYWP.......

QEKDPNLlVTESGIRVTTEevAKSRDFILRTFRLE---WNDKEHFVKHLALNNWPDYGVPSSPRAVLRAIE-VARDIRYRN--PGQPIVVHCSAGVGRTG
.|.. .    .  .. ..|   . .|.|||.....    ...|. | ..  ..||| |||..| |||  .| | |  .. .     |||||||||.||||
deeekee.yGkisvtnvse..ksladYilRelsvskkkkkkeerevfqyhfksWPdhgvpkdpgavLdfledvnrkqeeleeaeagpivvhCsaGiGRtG

ILVAVDIGIDMLLA---GRRVNLTSIVQHMREDRGGMLQTFPQYEFAFKAIGSFA
 .. .|| ....        ... ..|. .|| | |..||  || | .|||  . 
tfiviDillkliekkgldadidiqklvksvreqrsglvqteqqykfvykaikkyi
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 1245-1493 4.2e-51 169.0 In-house 53-287 (298) alignment 
Range on Protein: 1245-1493
Range on HMM: 53-287/298.0
LPKNAAQlCRYKNIVPNMDTVVKidpLFENNvKVENSDFINANWVRGFDGRQSYIATQGPKPNTIDHFWRMIIQHEVPLIIMATNLVEGDKIKCHRYWAl
 |.|  .  || .|..   . |    | ... . |.||.||| .. ...||...||||.| ..|.  ||||......  |.| |||.| ||.|.|.||  
kpenkkk.NRyadiialdssRvv...Leked.adeesdYiNAsflhaykgrnafiatqaPltetvedFWrmvteedigtiVmltnleeldktkyhkywP.

fdgIKGQEKDPNLLVtesgirvTTEEVAKSRDFILRTFRLEWND--KEHFVKHLALNNWPDYGVPSSPRAVLRAIEVARDIRYRNPGQPIVVHCSAGVGR
    .|.|.  .. |       .  .  .  |.| |.. .. ..  ||. |..|   .||| |||.  ..||  ..  |  ....  .|..|.|||||||
...degketygeitv.......sllskeefadlivrklkvskkkeekerevrqlhftsWpdkgvpenatsvldllrkvrasqqqagnkpvivqCsaGvgR

TGILVAVDIGIDMLLAGRRVNLTSIVQHMREDRGGMLQTFPQYEFAFKAIG
.|  .|.|  .. . . . | .  .|. .|..| |..||  || | ..|. 
sGtfiaidsvlervkkeqvvDvfqvvkvlRkkrpgavqteeqYvfiyeavl
subfamily_PTPN3_pd Subfamily PTPN3 1242-1492 1.4e-50 166.8 In-house 35-271 (280) alignment 
Range on Protein: 1242-1492
Range on HMM: 35-271/280.0
LADLPKNAAQlCRYKNIVPNMDTVVKIDplfENNvkveNsDFINANWV----RGFDGRQSYIATQGPKPNTIDHFWRMIIQHEVPLIIMATNLVEGDKIK
 | .|.|...  ||..|.|  .| ||..   |..    . |.||||.|     . .  . ||||||| ..|  .||.|. .... ||.| |.|||  ..|
aarkpenlsk.nryrdilpydatrvklk...ese....t.dyinanyvnmeipstglvnryiatqGPlaktatdfWqmvweqksslivmlttlverGrvk

CHRYWAlfdgikgQEKDpNLLVTesGIRVTTEEVAKSRDFILRTFRLEWND--KEHFVKHLALNNWPDYGVPSSPRAVLRAIEVARDIRYRNpGQPIVVH
||.||        ...| .|  .  ...|. |. .... ..|| . |. ..  .|. . .|   .||| |||...  .|. .|  |..|  .  .|.|||
ChqyWP.......eted.eleyg..efsvkcekedetksyvlrelvlkdketkeerkilqlqylaWpdhgvPddsadflefvervrklrsgk.eePvvvh

CSAGVGRTGILVAVDIGIDMLLAGRRVNLTSIVQHMREDRGGMLQTFPQYEFAFKAI
||||.||||.|..... . .. | . |.   ||..||. |. ..||  ||.|  .||
CsaGigrtGvlilletalalieaaepvypldivrtmrdqramlvqtasqykfvCeai
subfamily_PTPRG_pd Subfamily PTPRG 1253-1494 2.2e-49 163.1 In-house 51-285 (563) alignment 
Range on Protein: 1253-1494
Range on HMM: 51-285/563.0
CRYKNIVPNMDTVVKIDPLFENNVKVensDFINANWVRGFDGRQSYIATQGPKPNTIDHFWRMIIQHEVPLIIMATNLVEGDKIKCHRYWALfdgiKGQE
 || |||.   . ||. || ... |    |.||||.. |.   . .|||||| ..|.| ||||| ...| .|.| |||||  . ||..||       . |
nRylnivaydrsRvklsplpgkkkkl...DYinAnyidGyqkskafiatqgplkdtfddFWrmiWeqnvaiivmitnlvergrrkcdvYWPk....dese

KDPNLLVTEsgIRVTTEEVAKSRDFILRTFRLEWNDK---EHFVKHLALNNWPDYGVPSSPRAVLRAIEVARDIRYRNPGqPIVVHCSAGVGRTGILVAV
.  .| ||   |.  .  .  .| .... ..|. ...   |. |..    .||| |||...  ||  .. .   . .. | ||||||||||||||.....
tygalqvtl..ieeevlalytvrtlviknlklkkkkqcdteklvrqyhytkWPdhgvPehslpvLifvkkssaankaeaG.PivvHcsaGvgrtGtyivl

DIGIDMLLAGRRVNLTSIVQHMREDRGGMLQTFPQYEFAFKAIGS
|  .  . .   ||.  ...|.|  |  ..||  || | ..|. .
dtllkqiqqenavnvfgflkhiraqRnflvqteEqYiflhdalle
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 1241-1492 6.4e-49 162.0 In-house 54-287 (319) alignment 
Range on Protein: 1241-1492
Range on HMM: 54-287/319.0
NLADLPKNAAQlCRYKNIVPNMDTVVKIDPLfennVKVENSDFINANWVRGFDGRQSYIATQGPKPNTIDHFWRMIIQHEVPLIIMATnlvegdKIKCHR
. |.|..|  .  |. ||..   .|||...|    . .| ||.||| .| |.  .. |||.|||..||.. ||||| ....  |.. |      | || .
tfanldqnkdk.nriinilafdknvvklerl....iGeefsdyinasfvtGyqrkdkyiaaqGPldntladfWrmiweyncstivllt......kdkcsq

YWALfdgiKGQEKdpnllvtESGIRVTTEEVAKSRDFILRTFRLEWNDKEH---FVKHLALNNWPDYGVPSSPRAVLRAIEVARDIRYR-NPGQPIVVHC
|| |    |...|       |    |  . | .. ....| ..|  . ||.    ..   .  |||.||| .|  ..| ..  | .. . |  ..|||||
ywpl....kivik.......eerfkvkvdsveetaeyvvrdielsedgkekdirkitqfhflGwpdvGvpdypsdlmrlvkkvrhltskenhranivvhc

SAGVGRTGILVAVDIGIDMLLAGRRVNLTSIVQHMREDRGGMLQTFPQYEFAFKAI
||||||||. ...|. .|..   ..|..  .|. .|..|  ..| . || | . |.
saGvGrtGvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysal
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 1252-1493 1.3e-48 160.4 In-house 12-239 (250) alignment 
Range on Protein: 1252-1493
Range on HMM: 12-239/250.0
LCRYKNIVPNMDTVVKidpLFENNvKVENSDFINANWVRGFDGRQSYIATQGPKPNTIDHFWRMIIQHEVPLIIMATNLVEGDKIkCHRYWALfdgiKGQ
  || .|..   . |    |....   ..||.||| .. |.|.|...|||||| ..|| .||||......  |.| |||.| .|  .|.||      .. 
knryadiialdssrvv...Lekek.gdkesdyinasflhgyderkafiatqgPlqatiedfWrmvleeksgtivmLtnLkesekt.yhqywPv....eka

EkdpnllvTESGIRVTTEEVAKSRDFILRTFRLEWNDKEHF--VKHLALNNWPDYGVPSSPRAVLRAIEVARDIRYRNPGQPIVVHCSAGVGRTGILVAV
|       .  ...|.  .  .  |.. |.. |  . |..   |..|   .||| |||   .|||  ..  .  . .   .|..|.|||||||.|  .|.
e.......kyGdvtvsllskeefadytkrklklskakkaderivrqlhfvvWPdkgvPevatavLellkkvqasqqqagnaPvivqCsaGvgrsGafiai

DIGIDMLLAGRRVNLTSIVQHMREDRGGMLQTFPQYEFAFKAIG
|  .. |   . |..  ... .|.|| .....  || | ...| 
davlerlkkekvvdvfkvikvlrkdrphavesleqyvfvyeiil
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 1241-1492 2.5e-48 160.0 In-house 18-251 (284) alignment 
Range on Protein: 1241-1492
Range on HMM: 18-251/284.0
NLADLPKNAAQlCRYKNIVPNMDTVVKIDPLfennVKVENSDFINANWVRGFDGRQSYIATQGPKPNTIDHFWRMIIQHEVPLIIMATnlvegdKIKCHR
. |.|..|  .  |. .|..   .|||...|    . .| ||.||| .. |.  .. |||||||..||.. ||||| ....  |.. |      | || .
tfanldqnkdk.nrighilafdknvvklerl....iGeefsdyinasfitGyqrkdkyiatqGPldntladfWrmiweyncstivllt......kdkcsq

YWALfdgiKGQEKdpnllvtESGIRVTTEEVAKSRDFILRTFRLEWNDKEH---FVKHLALNNWPDYGVPSSPRAVLRAIEVARDIRYR-NPGQPIVVHC
|| |    |...|       |   .|  . | .| ....| ..|  . ||.    ..   .  |||.||| .|  ..| ..  | .. . |  ..|||||
ywpl....kivik.......eerfkvkvdsveeseeyvvrdielsedgkekdirkirqfhflgwpdvgvpdypsdlmrlvkkvrhltskenhranivvhc

SAGVGRTGILVAVDIGIDMLLAGRRVNLTSIVQHMREDRGGMLQTFPQYEFAFKAI
||||||||. ...|. .|..   ..|..  .|. .|..|  ..| . || | . |.
sagvgrtgvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysal
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 1253-1492 3e-48 159.5 In-house 55-280 (297) alignment 
Range on Protein: 1253-1492
Range on HMM: 55-280/297.0
CRYKNIVPNMDTVVKIDPLFENnvkvENSDFINANWVRGFDGrqSYIATQGPKPNTIDHFWRMIIQHEVPLIIMATNLVEGDKiKCHRYWAlfdgikgqE
 |||||.|     ||.  . ..     .||..|| .|.|.     .|.|| |...|.. ||.|.....|  |.| ... |.|| || |||.        .
sRYkniLPydssRvkLaivndd....pdsDyvnasfvkgnkh..rlittqmPmkatvadfWamvldeqvstivmlnddnerdk.kcaryWs........d

kdpNLLVTESGIRVTTEEVAKSRDFILRTFRLEWND--KEHFVKHLALNNWPDYGVPS--SPRAVLRAIEVARDIRYRNPGQPIVVHCSAGVGRTGILVA
   .  .|   . |... |.. . || |.. .. ..  ....||     .|||  |.   | ...|  |.  |.    |   |..|||.|||||||.|..
...kgvttfGdvsvvllsvsereGfikrelevtkgkakarrvvkqyqfveWPdkaverkdsassllklisevrkdfsqnaegPllvhclaGvGrtgvllt

VDIGIDMLLAGRRVNLTSIVQHMREDRGGMLQTFPQYEFAFKAI
.|  .        |..  .|...|..|  ..||  ||.| ..|.
idsvvaeakrekevdifglvkklrqerpylvqtkeqykfvyvav
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 1253-1492 8.5e-48 157.7 In-house 47-272 (515) alignment 
Range on Protein: 1253-1492
Range on HMM: 47-272/515.0
CRYKNIVPNMDTVVKIDPLfENNvkvENSDFINANWVRGFDGRQSYIATQGPKPNTIDHFWRMIIQHEVPLIIMATNLVEGDKIKCHRYWAlfdgikgqe
 |||||.|   . ||.. . ..|    .||..||  ...||  ..|||.|||.. ..| |||...|..|  |.| |.| ||||||| .||          
nryknilPydsvrvklevi.ndn...PhsdyfnasyipsfdndkayiasqgPnkasvddfWrlvlqenvttiamvtklkegdkikcgkyWP.........

KDPNLLVTESGIRVTTEEVAKSRDFILRTFRLEWNDKEHFVKHLALNNWPDYGVPSSPRAVLRAIEVARDIRYRNPgQPIVVHCSAGVGRTGILVAVDIG
. |   |    |.| .  .    . | |....  .|. . |    ...||| |||   ...|. |   .  . .    |...||||||||||.....|  
dkpgdsvkfGsikvelvsleactggikrkltvlkgddsrtvtqfhfteWPdkGvpkhtssllklikevkadhgqyt.hpliihcsaGvGrtGvvisidsv

IDMLLAGRRVNLTSIVQHMREDRGGMLQTFPQYEFAFKAI
.     .| |..  .|. .|..|  ..||  || | . |.
vahakttrmvdvfnfvtnirqkrpylvqtqeqyafiygav
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 1247-1491 7.4e-47 154.6 In-house 44-278 (290) alignment 
Range on Protein: 1247-1491
Range on HMM: 44-278/290.0
KNAAQLCRYKNIVPNMDTVVKIDPLFENNvkVENSDFINANWVRGFDGRQSYIATQGPKPNTIDHFWRMIIQHEVPLIIMATNLVEGDKIKCHRYWAlfd
..  .| |..|||.. |  . . |. ...    . ..||| .. |.  ...||||||| .||. .||..| |..|. |.| || .| .| ||. ||.   
ssnkllnRfanivvyddnritLrpisghk..DCtneyinAcyikgykekkqyiatqgpvsntlvdFWkliwqekvtiivmltniieegkvkCqqYWp...

gikgqEKDPNLlVTESGIRVTTEEVAKsrDFILRTFRLEWNDK---EHFVKHLALNNWPDYGVPSSPRAVLRAIEVARDIRYRNPGQPIVVHCSAGVGRT
     ..| .  . |  |... ||. .  ..| |..... ...   .. |... . ||.. |    | ..| .||   ......  ..||||||..|||.
.....dsdtka.ygefsikllneetln..eyierklevknknsagakqsvtqyqitnwdstgkvtnpqtillvieemyktqrkrgntsivvHCSdtvgrs

GILVAVDIGIDMLLAGRRVNLTSIVQHMREDRGGMLQTFPQYEFAFKA
....|....|.       ... ......|  . |..||  ||.. |. 
avfcaaattinkcktegvidvfqvlksqRiqkpgsvqtvqqyqgifqi
subfamily_PTPRK_pd Subfamily PTPRK 1253-1492 4.1e-46 152.2 In-house 47-273 (314) alignment 
Range on Protein: 1253-1492
Range on HMM: 47-273/314.0
CRYKNIVPNMDTVVKIDPLFENnvkvENSDFINANWVRGFDGRQSYIATQGPKPNTIDHFWRMIIQHEVPLIIMATNLVEGDKIKCHRYWalfdgikgqe
 |...|..   . |.. .. ..     .||.|||... ..   . .|.||||...|.  |||.. ...   |.| |.|||  ..|| .||          
nrsgdilaydrsrvflitidgd....pssdyinaalidsykrpaafivtqgPlqetvkdfWrlvydencasivmltelvevgrvkClkyW..........

kdPNLLVTESGIRVTTEEVAKSRDFILRTFRLEW----NDKEHFVKHLALNNWPDYGVPSSPRAVLRAIEVARDIRYRNPGqPIVVHCSAGVGRTGILVA
  |.   .   |.|.  |.    ... |.||.|      .. . |...   .|||..|| | ...|. .      .  . | .|||||||| ||||. .|
..PedtevygdikvelvetellaelvvrifrveklargqeeirevrqfqflgWpdhdvPvsatgllklvrrvkksqeeeaG.rivvhCsaGaGrtGtfia

VDIGIDMLLAGRRVNLTSIVQHMREDRGGMLQTFPQYEFAFKAI
.|| .||.   . |..  .|. .|. .  |..|  || | . .|
idivldmieregvvdvfnavktlrsrkvnmveteeqykfiydvi
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 1252-1493 3.1e-45 149.4 In-house 47-274 (315) alignment 
Range on Protein: 1252-1493
Range on HMM: 47-274/315.0
LCRYKNIVPNMDTVVKIDPLfENNvkvENSDFINANWVRGFDGRQSYIATQGPKPNTIDHFWRMIIQHEVPLIIMATNLVEGDKIKCHRYWAlfdgikGQ
  |||||.|   . ||.. . ...    .||.|||  ....|  ..|||.|||.. ..| ||||..|..|  |.| |.. ||||||| .||        .
knryknilPldsarvklevi.dds...PdsdyinasyiksvdddkayiasqgPlkasvddfwrmvlqekvttivmvtkkqegdkikcrqywP......dr

EKDpnlLVTESGIRVTTEEVAKSRDFILRTFRLEWNDKEHFVKHLALNNWPDYGVPSSPRAVLRAIEVARDIrYRNPGQPIVVHCSAGVGRTGILVAVDI
. |   .|    |.|.. ..    | . | . .   .. . |    ...||| ||.    ..|. |   .    ..   ...|||||||||||.....| 
kad...svefGsikvellsleadtdgvarklvtrkseesrtvtqfqftewPdkGvdkqtssllklikevkad.ngkkefsllvhcsaGvGrtGvviside

GIDMLLAGRRVNLTSIVQHMREDRGGMLQTFPQYEFAFKAIG
 .. .  .| |..  .|. .|..|  ..||  .| | . |. 
vvaqikrtrsvdvfnfvknlrakrpylvqteeeyafiydavl
subfamily_PTPN23_pd Subfamily PTPN23 1253-1497 7.5e-44 144.7 In-house 47-281 (288) alignment 
Range on Protein: 1253-1497
Range on HMM: 47-281/288.0
CRYKNIVPNMDTVVKIDplfennvkVENSDFINANWVRGFD-GRQSYIATQGPKPNTIDHFWRMIIQHEVPLIIMATNLVEGDKIKCHRYWALFDGIKGQ
 |...|.|   . ||..         .. |.||| .|..   |  ..||||.|...|.  ||.|. .  ...|.| ..  | .| |..|||    |   .
nrsrdilPyDhnRvklr........gskDDYinAsfvkdlspgcPdfiatqaPlqstlnDFWlmvyeqkssviVmllskeelgkpkvdrYwPedkgetvk

EKDpnllvtesgIRVTTEEVAKSRDFILRTFRLEWNDKEH--FVKHLALNNWPDYGVPSSPRAVLRAIEVARD---IRYRNPGQPIVVHCSAGVGRTGIL
 .|         ..|| ..| ..  .. |...|| .|...   |.|| |..||..|||.||  .|. ......    . |.  .|.||||||||||||..
fgd.........lsvtlksvretethvervlkletldadavksvshlqltsWpelGvPasPetllqfldevesayeavqrksktPlvvhCsaGvgRtgvf

VAVDIGIDMLLAGRRV-NLTSIVQHMREDRGGMLQTFPQYEFAFKAIGSFAR
  |   .  | .|  . ..  .|...||.|  |.|.  |..|...|.   ||
alvyaavrelekgnglldiiqvvsrlreqRrfmvqekeqlkfsyeavleaar
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 1250-1492 1.1e-43 144.4 In-house 50-275 (315) alignment 
Range on Protein: 1250-1492
Range on HMM: 50-275/315.0
AQLCRYKNIVPNMDTVVKIdPLFENNvkvENSDFINANWVRGFDGRQSYIATQGPKPNTIDHFWRMIIQHEVPLIIMATNLVEGDKIKCHRYWAlfDGik
 |  || ||..   . |.. || ||.   ..||..|||.. |.. .. |||.|||...... |||.. ....  |.| ||||||.| |. .||   |   
kqknryiniiaydksrvql.pllend...phsdyvnanfidGynkkrryiaaqgpnvasvkdfwrlvfeedigkivmltnlvegekrkaekywp..dk..

gqekdpnlLVTESGIRVTTEEVAKSRDFILRTFRLEWNDKEHFVKHLALNNWPDYGVPSSPRAVLRAIEVARDIRYRNPgQPIVVHCSAGVGRTGILVAV
         |.   | ||  .  .  ..  ||.    .|. . |  | .  ||| ||| .  ...  |  ..  .  .   .||||||||||||| ....
........kviyGkitvtrkseevnteytvrtlsvvfgdnirevvqlhytswpdmgvpkytiplmnlirtvkqhhtnsv.gaivvhcsaGvGrtGtfitl

DIGIDMLLAGRRVNLTSIVQHMREDRGGMLQTFPQYEFAFKAI
|  .| . | . ...  ... .|. | .|.|.  ||.| ..|.
davldqaeaenaidvynfitgvrqnrikmvqvaeqyqfiydal
subfamily_PTPN1_pd Subfamily PTPN1 1243-1492 1.3e-43 143.8 In-house 27-267 (290) alignment 
Range on Protein: 1243-1492
Range on HMM: 27-267/290.0
ADLPKNAaQLCRYKNIVPNMDTVVKIDplfennvkVENSDFINANWVRGFDGRQSYIATQGPKPNTIDHFWRMIIQHEVPLIIMATNLVEGDKIKCHRYW
|.||.|  .| ||... |   . .|..         .. |.|||. |   . ..||| |||| |||.||||.|. ...   ..|  ..|| ..|||..||
aklpenr.nlnryrdvspydhsrikle........radndyinaslveleeakrsyiltqGPlpntvdhfWqmvWeqkskavvmlnkvvekeqikcaqyw

ALFDGikgqekDPNLLVTESGIRVTTEEVAKSRDFILRTFRLEW--NDKEHFVKHLALNNWPDYGVPSSPRAVLRAIEVARDIRYRNP-GQPIVVHCSAG
   .       . .||. .. ..|.  .  ... ...|...||    .. . . |     |||.|||.|| | |. .   |.    ..   | |.|||||
Pqgee......ekellledtklkvkliseerksyytvrllelenlktqetreilhfhyttwpdfgvpespaaflkflfkvresGslssdvGpavihcsaG

VGRTGILVAVDIGIDMLLAGR---RVNLTSIVQHMREDRGGMLQTFPQYEFAFKAI
.||.| .. ||  .  . .      |..   . ..|. | |..||  | .|.. ||
iGrsGtfclvdtclvliekkddlssvdikkvllelrkyrlGliqtadqlrfsylai
subfamily_PTPN14_pd Subfamily PTPN14 1242-1493 1.8e-43 143.6 In-house 43-293 (300) alignment 
Range on Protein: 1242-1493
Range on HMM: 43-293/300.0
LADLPKNAAQlCRYKNIVPNMDTVVKIDPLFENnvkveNSDFINANWVRGFDG--RQSYIATQGPKPNTIDHFWRMIIQHEVPLIIMATNLVEGDKIKCH
 | ||.|| .  |.|...|  |. |.. |  ||     ....|||  ..   |  ..|||..||| ..|.  ||.|. ...| ||.| |.  |. | |..
taklpenaek.nrfkdvlPyednrvelsptken.....stgyinassikvsvggkersyivaqgPleltvqdfWqmvWeqgvqlivmlteeeedgkeksf

RYWAlfdgiKGQEKDPNllVTESGIRVTTEEVAKSRDFILRTFRLEW--NDKEHFVKHLALNNWPDYGVPSSPRAVLRAIEVARDIRYR--------NPG
.|.      | ..|  .  |.    .|||. . .|  .| ....|..    .|  | ||  ..||| |||. ..  |  .|  . .|..        .  
kyfP.....kleskkkt..vefgkfkvttkfsedsdsvittglklkhlpskeertvwhlqytDWpdhgvPeDvkgflsyLeevqsvrrktnseveskesk

QPIVVHCSAGVGRTGILVAVDIGIDMLLAGRRVNLTSIVQHMREDRGGMLQTFPQYEFAFKAIG
 |..|||||||||||.|. .|. |  |  ...... ......|| |  ..||. ||.| .|.. 
PPvlvhCsaGvGrtGvlilsdlliatlehneeidikkvlarLreqrmllvqtlaqYkfvYkvli
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 1249-1496 1.1e-42 140.7 In-house 38-277 (287) alignment 
Range on Protein: 1249-1496
Range on HMM: 38-277/287.0
AAQLCRYKNIVPNMDTVVKIdplfENNvKVENSDFINANWVRGFDGRQSYIATQGPKPNTIDHFWRMIIQHEVPLIIMATNLVEGDKIKCHRYWAlfdgi
|..  || ...|  || | .     ..     ||.||||.| ..   ...||.||| . |.  |||.......  .|. |  ||  . ||..||      
avkknryadvlPiddtrvll....sae.gelGsdyinanyvasytddeafiaaqgPiaatvrdfwravletrsasvitmtreveearlkcykywP.....

kgqEKDPNLLVTesGIRVT-TEEVAKSRDFILRTFRLEW-NDKE-HFVKHLALNNWPDYGVPSS----PRAVLRA---IEVARDiryRNPGQPIVVHCSA
   |..  ..|   |  |.  .   |. ..  |..||   . .| . || | | .||| ... .     | ||     ||.|||    .   |.|||...
...erevPmrvG..GysvvlldydikePeygvralrlidletrearvvkqldllswPdkvlaPtavglirfvldvkqhielard...asevGPlvvhddv

GVGRTGILVAVDIGIDMLLAGRRVNLTSIVQHMREDRGGMLQTFPQYEFAFKAIGSFA
|.||.|||.|. . ...|.   ||. . .| ..|| | ...|.  |. . ..|. .. 
GiGrsGillatlvlvsrledlGrvdvaavvirlreyraalvqavvqlrllyealvtyy
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 1250-1492 5.9e-42 138.6 In-house 48-274 (287) alignment 
Range on Protein: 1250-1492
Range on HMM: 48-274/287.0
AQLCRYKNIVPNMDTVVKIDplfennvkVENSDFINANWVRGFDGRQSYIATQGPKPNTIDHFWRMIIQHEVPLIIMATNLVEGDKIKCHRYWAlfdgik
 .. |...|..  .  | .          |. |.||| .. |.  .. .|....|  ||.  ||..| ...|. |.| ... | |. .|..||.      
kdknRltqilvpdnyrvllk........gehpdyinavfidgykekkafiiaesPmfntarnfWkliddrnvtaivmlcqekendeevcyqyWp......

gqE-KDpnLLVTESGIRVTTEEvaKSRDFILRTFRLEWND---KEHFVKHLALNNWPDYGVPSSPRAVLRAIEVARDIRYRNPGQPIVVHCSAGVGRTGI
  | |   ... |  |... ||  .. ..| |..... ..   ... ||   . ||.. |  ..|...|  ||     ....   .||||||..|||...
..eeks..vvlGeyniellnee..vnagyierklevknknkagdkqqvkqyqitnWdstgkvtepqtillvieemyktqrkrgntsivvhCsdtvGrsam

LVAVDIGIDMLLAGRRVNLTSIVQHMREDRGGMLQTFPQYEFAFKAI
..|....|.       ... ......|  . |..||  ||.| ....
fcaaattinkckteGviDvfqvlksqriqkpgsvqtveqykfindiv
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 1249-1496 7.1e-41 134.8 In-house 40-293 (301) alignment 
Range on Protein: 1249-1496
Range on HMM: 40-293/301.0
AAQLCRYKNIVPNMDTVVKIDPlfENNVKVENSDFINANWVRGFDGRQSYIATQGPKPNTIDHFWRMIIQHEVPLIIMATNLVEGDKIKCHRYWALFDGI
 ..| |.|||..  |  . . |  ..|... . ..|||... |.  .. .||.|||  .|.  |||.|.|. .  |.| ||| || | ||..||   .  
nkalnrfknitvyddnriilkp..kpnldlcqreyinasyidgysekkkfiaaqgpmkktlvdfWrliwqekpvsivmvtnlkegtkskceqywpnseae

KGQEKDPNLLVTESG------IRVTTEEVAKSRD--FILRTFRLEWNDKEHFVKHLALNNWPDYGVPSSPRAVLRAIEVARDIRYRNPGQPIVVHCSAGV
. ..   . .....       ||  .  . .. .  .| |.|. . . . . |  | . .||. ||   || ||..|.     . .  | |.|||||..|
seefgpftvtlvneqvyPdfvirqlnvkiqdgsnngyierkfkvksdksswdvlqlqvtdWpqdGvvreprtvLqviddvihrqqkigggpvvVHCSdtV

GRTGILVAVDIGIDMLLAGRRVNLTSIVQHMREDRGGMLQTFPQYEFAFKAIGSFA
.|.|. ..|.||..   |   |..  ... .|  . |. .|  || . ...|  . 
srsGvYcsvsiglEQckaegVVdvfqvtkavrrskpgaVtTLeqytsiydvidmyl
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 1279-1491 1.9e-40 133.8 In-house 65-272 (307) alignment 
Range on Protein: 1279-1491
Range on HMM: 65-272/307.0
ENSDFINANWVRGFDGRQSYIATQGPKPNTIDHFWRMIIQHEVPLIIMATNLVEGDKIKCHRYWALFDGIKGQEKDPNLLVTESGirVTTEEVAKSRDFI
  ||.| ||..      . .|..|||. ||. .|| |.||..|  .||  ...|  ||||..|| | .| |    . .  .. .   . ....|   |.|
lasdyihanylgiaikpkkficaqgplentqysfwamaiqekvesvimlckvielakikceqywpleegqklvfgeapntisvan..lgakklapdedli

-LRTFRLEWNDKEHFVKHLALNNWPDYGVPSsprAVLRAIEVARDIRYRNpgQPIVVHCSAGVGRTGILVAVDIGIDMLLAGRRV-NLTSIVQHMREDRG
 . |....| .|   ..||  .|||| |||      | ||..   .|| .   |.||||||||||.| .||. .  | ..||    ..  .|. .|..| 
nvttlkvdwaqksrtiqhlqwenwpdrgvpq...inltainlleavrydt..npvvvhcsaGvGrsGtivaislvqdkmiaGinckdmkklveelrsqrh

GMLQTFPQYEFAFKA
  .||  || .  . 
yaiqteaqylylhrv
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 1242-1492 2.3e-40 133.7 In-house 42-284 (325) alignment 
Range on Protein: 1242-1492
Range on HMM: 42-284/325.0
LADLPKNAAQlCRYKNIVPnMDtvvKIDPLFENNVKVENSDFINANWVRGFDGRQSYIATQGPKPNTIDHFWRMIIQHEVPLIIMaTNLVEGDKIKCHRY
 | .|.| |.  |.||.|. .|   |  . .|   .  .||.|||...| . ... ..|.| |...||. .||.... . ..... .| ....| .|  |
vamkpenkak.nrfknvva.ld...ksrvvletkkddpssdyinasylrddkkkdvflaaqaPltatindlWrlvldWrcsvvvv.lneldlgkdrcavy

WAlfdgiK--GQEkdpnllVTESGIRVTTEEVAKSRDFILRTFRLEWNDKE--HFVKHLALNNWPDYGVPSSPRAVLRAIEVARD----IRY-RNPGQPI
|      |  |.       .|  |..|    . .  |.. | . .   .|     || . |  |.| ||.  | ...  ...       ..   .   ||
wp.....kemgks......ktfGglevklrtieeisdyvhrvldvkqvkkGetrsvkqfqlqswddmGvqkrpatlisilqlvkavservtantkastpi

VVHCSAGVGRTGILVAVDIGIDMLLAGRRVNLTSIVQHMREDRGGMLQTFPQYEFAFKAI
.|||||||||||.....   .. ..   ||..   |...|.||  |..|  || . ..|.
lvhcsaGvGrtGvfislysalakvieesrvdifgfvkklrkdrpsmvetvdqyiliyeal
0041856 (Phosphotyrosine protein) phosphatases II 1253-1491 1e-39 131.3 In-house 5-166 (182) alignment 
Range on Protein: 1253-1491
Range on HMM: 5-166/182.0
CRYKNIVPNMDTVvkidplfennvkveNSDFINANWVRGFDGRQSYIATQGPKPNTIDHFWRMIIQHEVPLIIMATnlvegdkikCHRYWAlfdgikgqe
 ||..|.|.  .               ..|.||||...|    . .|||||| ..|. .|.||. .. . .|...|         ...||.         
nrysdilpydhsr..............dldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt.........eelywp.........

kdpnllvtesgirvtteevaksrdfilrtfrlewNDKEHFVKHLALNNWPDYGVPSsPRAVLRAIEVARDiryrnPGQPIVVHCSAGVGRTGILVAVDIG
                                  .. |. . ..   .|||.|||. .. .|. || ...     .| |..||||||||||| ||| .. 
..................................ellerlgiqylylpwpDhgvpd.ldelldfieevle.....eggpvlVHCsaGvgRtgtlvaaylm

IDMllagrRVNLTSIVQHMREDRGGMLQTFPQYEFAFKA
. .     .|.|...|...|. | || .|  || |   |
kkl.....gvsleeavklvrsrRpgmvitpnqyfflqla
0051429 (Phosphotyrosine protein) phosphatases II 1279-1495 2.4e-39 131.0 In-house 2-224 (272) alignment 
Range on Protein: 1279-1495
Range on HMM: 2-224/272.0
ENSDFINANWVRGFdGR----QSYIATQGPKPNTIDHFWRMiIQHEVPLIIMATNLVEGDKIKCHRYWalfdgikgqE----------KDPNLLVTESGI
. |. |||..| |. ||      .....|| |.|...|||.  .. .  |.. ....| .. ||.|||         .           |    ..   .
plsgyiNardvggy.grvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdryw.........pgirylhlpilddsaptilygal

RVTTEEVAKSRDFILRTFRLE---WNDKEHFVKHLALNNWPDYGVPSSPraVLRAIEVARDiryrnpGQPIVVHCSAGVGRTGILVAVDIGIDMLLAGRR
|||. ..    |.|||...|.    ... . | ||   .|||.|||...  .|...|. .|      |.|..||||||..|||..||... .  . .   
rvtllseellldyilrellltlllsagearevmhlhytdwpdhgvpqea..llellellld......ggpvlvHCsaGkdRTGtvvallllllgvsleti

VN--------LTSIVQHMREDRGGMLQTFPQYEFAFKAIGSF
|.        |  .|...|. | |. ||  ||.| ..|.  .
vddYlltnlyleeaveelraqrpgavqteeqylflyeallel
0043147 (Phosphotyrosine protein) phosphatases II 1279-1488 3.5e-39 129.6 In-house 3-153 (172) alignment 
Range on Protein: 1279-1488
Range on HMM: 3-153/172.0
ENSDFINANWVRGFDGRQSYIATQGPKPNTIDHFWRMIIQHEVPLIIMATNLvegdkikchrywalfdgikgqekdpnllvtesgirvtteevaksrdfi
|.||.|||... .    ...|||||| .||...||||. .. . .|...|.|                                                
egsdyinasyldlyyipdrfiatqgplrntladfwrmlkelgithivnltel................................................

lrtfRLEWNDKEHFVKHLALNNWPDYGVPsSPRAVLRAIEVARDIRYRNPGQPIVVHCSAGVGRTGILVAVDIGIdmllagRRVNLTSIVQHMREDRGGM
     . . . |... ..   .|||.||| ... .|...|  ...  ..|| |..||||||||||| ||| .. .      ....|  .|...|| |.|.
....lydpellerlgiqylylpwpDhgvp.llellleflefidellalspggpvlVHCsaGvgRtgtlvaaylml......lglsleeavalvrekRpga

LQTFPQYEFA
 |.. || | 
vqnpsqyrfl
subfamily_PTPRN_pd Subfamily PTPRN 1248-1492 2.2e-38 126.7 In-house 55-288 (297) alignment 
Range on Protein: 1248-1492
Range on HMM: 55-288/297.0
NAAQLCRYKNIVPNMDTVVKIDplfeNNVKVENSDFINANWVRGFDGRQ-SYIATQGPKPNTIDHFWRMIIQHEVPLIIMATNLVEGDKIKCHRYWAlfd
....  |.|...|  .. ||..    .. . |.||.|||  .   | |. .||||||| ..|. .||.|. .. | .|.. |.| | .  .|.|||    
knvkknrskavlpydhsrvklk....eeasaeksdyinasaildhdprapayiatqgplastvadfwqmvweqGvvvivnltrleeegvkqckrywp...

gIKGQEkdpnlLVTESGIRVTTEEVaKSRDFILRTFRLEW--NDKEHFVKHLALNNWPDYGVPSSPRAVLRAIEvARDIRYRNPGQPIVVHCSAGVGRTG
  .|.|     .     ... .| .  . |...|.| |    ...   |  .    ||. |||.|....|       .  ||    |||||||.|.||||
.deGse.....vyhiyevhlvsehi.wcddylvrsfylknlqtsetrtvtqfhflswpeegvPasaksllefrr.kvnksyrGrscpivvhcsdGaGrtG

ILVAVDIGIDMLLAG-RRVNLTSIVQHMREDRGGMLQTFPQYEFAFKAI
. ...|. .. || | ....... ..|.|..| |...|  |.|||..|.
vyilidlvlnrllkGvkeidiaatlehlrdqrpglvktkdqfefaltav
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 1252-1492 2.7e-38 126.3 In-house 59-279 (290) alignment 
Range on Protein: 1252-1492
Range on HMM: 59-279/290.0
LCRYKNIVPNMDTVVKIDplfennvKVENSDFINANWVRGFDgrQSYIATQGPKPNTIDHFWRMIIQHEVPLIIMATNLVEGDKIKCHRYWAlfdGIKGQ
  |||..| |  | | ..          . |.. ||.|.| .    .| |||.  .|.  .|||..|..|  |.|  .|.|  | ||..|.      .|.
knrykdvvcndktrvilk.......dGydGdyvhanyvkGlk..amfiltqGalkdtvidiwrmvlqekvaaivmlceliedGkakceqyyp...ekeGe

ekdpNLLVTESGIrVTTEEVAKSRDFILRTFRL--EWNDKEHFVKHLALNNWPDYGVPSSPRAVLRAIEVARDIryrnPGqPIVVHCSAGVGRTGILVAV
     |   |  . . .||  |  . |..|. .    . ||| .||| .  |||  |. |  |.|| . . | .    .| |.|||||||.|||| .||.
....vltfGeitv.lcseeddkdaniikktlsvrdkdsGkehklkhlkikswpdksvalstlallrtlrilrka....sG.pvvvhcsaGiGrtGtfvai

DIGIDMLLAGRRVNLTSIVQHMREDRGGMLQTFPQYEFAFKAI
..|...|| |. ..|  .|. .|. | . .|   ||    ...
evglqilldGkeldlldlvralrnsrlnsvqvdiqylalveil
0036282 (Phosphotyrosine protein) phosphatases II 1281-1488 5.1e-37 122.6 In-house 2-162 (174) alignment 
Range on Protein: 1281-1488
Range on HMM: 2-162/174.0
SDFINANWVRGFDGRQSYIATQGPKPntidhFWRMIIQHEVPLIIMATNLVEGDKIKCHRYWALfdgikgqekdpnllvtesgirvtteevaksrdfilr
||.|||... ..     .||.||| .     ||.|. .. .  ..| ....| .. ||..||                                      
sdyinaspldlsyitprliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe....................................

tfrlEWNDKEHFVKHLALNNWPDYGVPSSPRaVLRAIEVARDIRYRNPGQPIVVHCSAGVGRTGILVAVDIGIDMLLaGRRVNLTSIVQHMREDRGGMLQ
     ..| |... ..   .|||.|||...  .|.... ..... ..|| |..|||||||||||.||| .. . .||  . |.  ..|. .|  |.|| |
....lredlerlgiqylylpwpDhgvpdlsi.llefvkfveealsedpggpvlVHCsaGvgRtGtlvaaylmlrgll.eslvdaldlvrelRlqrpgmvq

TFPQYEFA
|. ||.| 
tpsQyrfl
0046846 (Phosphotyrosine protein) phosphatases II 1277-1490 5.7e-37 122.5 In-house 8-167 (176) alignment 
Range on Protein: 1277-1490
Range on HMM: 8-167/176.0
KVENSDFINANWVRGFDgrqsYIATQGPKPNTIDHFWRMIIQHEVPLIIMATNLVEGDKIKCHRYWALFDGIKGqekdpnllvtesgirvtteevaksrd
  ...|.||||.. |      .|||||| |.|. .|..|. .. . .... |..|| ...||..|| .. . .                           
ldldldyinanlilgsr....piatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgi..........................

filrtfrlewndkehfvkHLALNNWPDYGVPSSpRAVLRAIEVARDIRYRNpgQPIVVHCSAGVGRTGILVAVDigidMLLAGRRVNLTSIVQHMREDRG
                  .    .|||.|||.. ...|...|  |. . ..  .|..||||||.|||| ||| .    .|  .. ...  .....|| | 
..................qylhlpwpDhgvpdl.elllellefirealkeg..gpvlVHCsaGigRtgtlvaay....llelekglsveealalvreqRp

-GMLQTFPQYEFAFK
 |..||. ||.|  .
lgavqtpeQyrflye
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 1253-1491 2.3e-36 120.1 In-house 11-235 (239) alignment 
Range on Protein: 1253-1491
Range on HMM: 11-235/239.0
CRYKNIVPNMDTVVKIDPLfennVKVENSDFINANWVRGFDGR-QSYIATQGPKPNTIDHFWRMIIQHEVPLIIMATNLVEGDKIKCHRYWAlfdgiKGQ
 || |||    . | .. |     .   ||.|||...| .||  ..||||||    .   ||||. |    .|.| | |.|| | |||.||         
nryanivtydhsrvvlekl....sndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywp.....dst

EKDPNLLVTesgIRvtteEVAKSRDFILRTFRLEW--NDKEHFVKHLALNNWPDYGVPSSPRAVLRAI-EVARDiryRNPG-QPIVVHCSAGVGRTGILV
 |  || ||   .|    .     |.|.||| .    . .|..| .  .  ||| |||    |||    ....|     || .| |.|||||||||| ..
skycnlrvt...lr....ktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrkitkd...slpgarpwvihcsagvgrtgafl

AVDIGIDMLLAGRRVNLTSIVQHMREDRGGMLQTFPQYEFAFKA
 .|  .      . |..   |. .||||  |.||  || | . |
vidamlrqakkqktvdifnyvkairedrphmvqtseqyvfihla
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 1253-1491 2.5e-36 120.1 In-house 12-236 (239) alignment 
Range on Protein: 1253-1491
Range on HMM: 12-236/239.0
CRYKNIVPNMDTVVKIDPLfennVKVENSDFINANWVRGFDGR-QSYIATQGPKPNTIDHFWRMIIQHEVPLIIMATNLVEGDKIKCHRYWAlfdgiKGQ
 || |||    . | .. |     .   ||.|||...| .||  ..||||||    .   ||||. |    .|.| | |.|| | |||.||         
nryanivtydhsrvvlekl....sndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywp.....dst

EKDPNLLVTesgIRvtteEVAKSRDFILRTFRLEW--NDKEHFVKHLALNNWPDYGVPSSPRAVLRAI-EVARDiryRNPG-QPIVVHCSAGVGRTGILV
 |  || ||   .|    .     |.|.||| .    . .|..| .  .  ||| |||    |||    ....|     || .| |.|||||||||| ..
skycnlrvt...lr....ktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrkitkd...slpgarpwvihcsagvgrtgafl

AVDIGIDMLLAGRRVNLTSIVQHMREDRGGMLQTFPQYEFAFKA
 .|  .      . |..   |. .||||  |.||  || | . |
vidamlrqakkqktvdifnyvkairedrphmvqtseqyvfihla
0049260 (Phosphotyrosine protein) phosphatases II 1289-1489 1e-35 118.0 In-house 2-143 (152) alignment 
Range on Protein: 1289-1489
Range on HMM: 2-143/152.0
VRGFDGRQSYIATQGPKPNTIDHFWRMIIQHEVPLIIMATNLVEGDKIKCHRYWalfdgikgqekdpnllvtesgirvtteevaksrdfilrtfrlewnd
. |.   . .|||||| |||...||||. .. .  |.| |.|.| .|.||..|.                                              
idgyampfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi..............................................

kehfvkHLALNNWPDYGVPSSPRAVLRAIEVARDIrYRNPGQPIVVHCSAGVGRTGILVAVDIGIdmllagRRVNLTSIVQHMREDRGGMLQTFPQYEFA
      .    .|||.|||...  .| .... . . ....| |..||||||||||| ||| .. .      ..|.|  .|...|| | |. ... |..| 
......qylhlpwpDhgvpdlsqlllflllfiekl.aldkggpvlVHCsaGvgRtgtlvaaylml......lgvsleeavalvrekRpgavpnpgqlrfl

F
.
y
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 1279-1492 1.3e-35 117.8 In-house 27-235 (237) alignment 
Range on Protein: 1279-1492
Range on HMM: 27-235/237.0
ENSDFINANWVRGFDGR-QSYIATQGPKPNTIDHFWRMIIQHEVPLIIMATNLVEGDKIKCHRYWALFDgikgQEKdPNLLVTESgiRVTTEEVAksrDF
 .||.|||....||||  ..|||.|||  .. | ||.|. |    .|.| | |.||...|||.||   |    | . .   .| |      || .   |.
sgsdyinatylkgfdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywpstd....qpa.aygvltvs..lkkkeefs...dy

ILRTFRLEW--NDKE-HFVKHLALNNWPDYGVPSSPRAVLRAI-EVARDIRYRNPGQPIVVHCSAGVGRTGILVAVDIGIDMLLAGRRVNLTSIVQHMRE
 .|.. |    . ||  ...   .  ||| |||    |.||   ..    .. .   | ..|||||||||||.. .|  .      . |..   |. . |
tvrslllskrltlkevrlihqyqftswpdrgvpqqtaallrfrkniinrsphvsesgpwiihcsagvgrtgiflvidamlrqakekkvvdiynyvysiee

DRGGMLQTFPQYEFAFKAI
||  ..||  || | ...|
drpyiiqtkdqyvfihqti
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 1254-1492 2.6e-35 116.7 In-house 53-275 (439) alignment 
Range on Protein: 1254-1492
Range on HMM: 53-275/439.0
RYKNIVPNMDTVVKIdplfENNVKVENSDFINANWVRGFDGRQSYIATQGPKPNTIDHFWRMIIQHEVPLIIMATNLVEGDKikchrYWALFDGikgqek
|||....   | | .    ..   |  | .||||...|.   . |||||||| .| |.|||..|.. .  |.| |||||  |     ||   .       
rykdvgafdhtrvtl....qeipgvphshyinanyikGyyddklyiatqgpkkettddfwrlviekktvtivmltnlvesyk.....ywpsdae......

dpnLLVTEsgIRVTTEEVAKSRDFILRTFRL----EWNDKEHFVKHLALNNWPDYGVPSSPRAV---LRAIEVARDiryRNPGQPIVVHCSAGVGRTGIL
       .  | | ..   .  ....| |..    . ..||. | ..    |||  ||.    |   ||||. | |   ..   |.|||||||||||| .
...vcygd..iavrvdrnielpnyvirgfkvfnerdttekertvlqfhyiawpdknvpaqashvldflrainsand...keeygpvvvhcsagvGrtGti

VAVDIGIDMLLAGRRVNLTSIVQHMREDRGGMLQTFPQYEFAFKAI
.|.|| .. | .  .|..  ||. .|..|  |.|.. || | ..|.
ialdialeqlklenkvdikgivkvlrkqrkqmvqalcqyvfiynav
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 1247-1492 4.7e-35 115.8 In-house 31-262 (283) alignment 
Range on Protein: 1247-1492
Range on HMM: 31-262/283.0
KNAAQLCRYKNIVPNMDTVVKIDPLFEnnvkvensDFINANWVR---GFDGRQSYIATQGPKPNTIDHFWRMIIQHEVPLIIMATNLVEGDKIKCHRYWA
..  .  |...|||    .|..... .        |.||| ..      .  . ||..|.|  .|.  ||.|. ....  |.| |.| |. .||| .|| 
denkrknrnqeivpadqwrvelksesr........dyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfdekitaivmltklqedlrikCsqyWP

lfdgIKGQEKDPNLLVTesgirVttEEVAKSRDFILRTFRLEWN---DKEHFVKHLALNNWPDYGvPSSPRAVLRAIEVARDIRYRNPGQPIVVHCSAGV
     .| |.  .. ||     .  ..   |. || . . |  |    .. .. |  ...| .|| . ..   |  ..  .  . ...  |||||||.|.
....krGsedyGeftvt.....l..rkettsnsfiikelllrvnssakstlllahyqvidWleyg.eqaiinslvkfnkvislqteskkgPivvhCstgi

GRTGILVAVDIGIDMLLAGRRVNLTSIVQHMREDRGGMLQTFPQYEFAFKAI
|||....|.   .. .|.   |.. ..|. |||.| ...||  || .  ...
Grtavfiaasasvkdaltesvvdvfavvkimreqrmmavqtldqyklvhelv
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 1251-1492 3.4e-34 112.9 In-house 47-232 (392) alignment 
Range on Protein: 1251-1492
Range on HMM: 47-232/392.0
QLCRYKNIVPNMDTVVKIDPLfennVKVENSDFINANWVRGFDGRQSYIATQGPKPNTIDHFWRMIIQHEVPLIIMATNLVEGDkikchrywalfdgikg
.  |||||.|   . ||.. .      . .||..|| ....||  ..|||.|||.. ..| ||||. |..|  |.| |.| |||                
kknryknilpydsarvklevi....ddipdsdylnasyipsfdnekayiasqgpnaaslddfwrmvfqenvttiamvtklkegd................

qekdpnllvtesgirvtteevaksrdfilrtfrleWNDKEHFVKHLALNNWPDYGVPSSPRAVLRAIEVArDIRYRNPGQPIVVHCSAGVGRTGILVAVD
                                     |. . |    . .||| .||    ..|. |.    . . .  .|...||||||||||.....|
...................................kgddartvaqfhftewPdkdvpkhtssllkfikev.kadfGqythpliihcsagvgrtgvvisid

IGIDMLLAGRRVNLTSIVQHMREDRGGMLQTFPQYEFAFKAI
  .      | |..  .|  .|. |  |.||  || | . |.
svvahakktrmvdvfnfvtnirrkrpymvqtkeqyafiygav
0049772 (Phosphotyrosine protein) phosphatases II 1242-1492 8.1e-34 113.1 In-house 40-276 (314) alignment 
Range on Protein: 1242-1492
Range on HMM: 40-276/314.0
LADLPKNaAQLCRYKNIVPNMdTVVKIdPlfenNVKVENSDFINANWVRGFdgrQSYIATQGPKPNTIDHF----------WRMII--QHEVPLIIM---
 |||..|     ||..|.|   . |.. |    .. |..||.|||..|.||   ...||||||...|.. |          |||..  .. |  | |   
vadlfln.rdknryldilpad.nrvil.p....glpvsgsdyinasyvdgf...lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivmsrd

------------------ATNLVEGDKIKCHRYWALFDgikgqekdpnllvtesgirvtteevaksrD-------FilrtfrlewndKEHFVKHLALnNW
                   ..| ..  . . ....|.                              .       |           ... .|.| . ..
evladelsrLdaAlgKtpllildgngneptaadlellk.............................eelydpelf...........erlgikylri.pv

PDYGVPsSPRAVLRAIEVARDIryrNPGQPIVVHCSAGVGRTGILVAVDIGIDMLlagrRVNLTSIVQHMREDRG-----GMLQTFPQYEFAFKAI
||...| ... .....|. ..    ..| |..|||.||.|||| .|.... .  |    .|.|  .....|. |      |..... |||| ..|.
pDgsap.lledfdeflefieea...dkggpvlvHCkaGkgRtgtfvvaaylmkll....gvsleealedvrlkRpinpnpgfieqleqyefileal
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 1271-1503 7.5e-33 108.6 In-house 60-294 (305) alignment 
Range on Protein: 1271-1503
Range on HMM: 60-294/305.0
LFENNVKVEN---SDFINANWVRGFDGRQSYIATQGPKPNTIDHFWRMIIQHEVPLIIMATNLVEGDKIKCHRYWALFD--GIKGQEKDPNLLV-TESGI
| .| ||.|.    ..| ||.|      . .| || |  .|   || | .|. |  |.|  ||.|    ||. |.|  |   .. .||.  . |  ||  
ldnnrvklegpwpheyihanyvstptnpkrfictqaplektcadfwymclqdkveaifmlcnllekgakkcleyfaskdkdvlefeekgqkisvkfessv

RVTTEEVAKSRdFILRTFRLEWN-DKEHFVKHLALNNWPDYGVPSSPRAVLRAIEVARDIRyrnpgQPIVVHCSAGVGRTGILVAVDIGIDMLLAGRRVN
..  .. ||..      . .|    | . |.|   ..||| |||..  |.|  .| ||  .      |||||||||.|||| .| ..  .| ||||. ..
tlkfrkdakak.vtetvlviegpgekarkvthyhwidwpdrgvpaadlailellekarpsk.....gpivvhcsagigrtgsvvmleyildqllagqiie

LT-SIVQHMREDRGGMLQTFPQYEFAFKAIGSFARLYGMLN
 |  |.|..||.|   .||  || |  . |  . |  ..|.
dtdkilqkireqrnnsiqtdaqylfvhqvilnyfrkkklld
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 1254-1491 6.1e-32 105.5 In-house 60-284 (305) alignment 
Range on Protein: 1254-1491
Range on HMM: 60-284/305.0
RYKNIVPNMDTVVKIDplfennvKVENSDFINANWVRG-FDGRQSYIATQGPKPNTIDHFWRMIIQHEVPLIIMATNLVEGDKIKCHRYWALFDGIKGQE
||...  .  ..||.|       |   ||.| ||.|   .   . .|..|||  .|||.|| |.||. |  |.|  . ||  |.|| .|| .  | | . 
ryqdvpcqdqsavkld.......kpspsdyihanyvgcpmipekrficaqgpldqtidefwwmviqnkveqivmlcktvelgklkcaqywpaaqgeklel

KDPNLLVTESGirvtTEEVAKSRDFILRTFRLEW-NDKEHFVKHLALNNWPDYGVPSSpraVLRAIEVARDIRYRNpgQPIVVHCSAGVGRTGILVAVDI
|   ..   ||    .  . .  .  . ...| .  |..  |.||  ..||| |||      | ..|.   ||  .   |||||||||.|||| .||.. 
ksgivvenvsg....skpmerdaeiqitllnltysgdqkmsvrhlqwtewpdrgvppc...kltslellsairgsk..vpivvhcsagigrtgtivaiey

GIDMLLAGRRV-NLTSIVQHMREDRGGMLQTFPQYEFAFKA
 .. .   ...  .  .|. .|..|   .|.  || |  . 
ilekiaenkpcppmpelvkalrdqrafsiqndvqylfihrv
Pkinase Protein kinase domain 99-246 1.6e-31 99.3 Pfam-A 84-226 (260) alignment 
Range on Protein: 99-246
Range on HMM: 84-226/260.0
DAERVAAEIKLLEENTVAFLIKETLKAIVHMHVHHVMHRDIKGGNILLDDEYAVCLTDFDTAYPYdPAEQATHFHAVGTPYWMAPEIAAcdypEGYAYDE
|  .. .. . |.|... ......|... ..| ....|||.|  |||||... ....||  |  .   .. .. . |||...||||.      ..  |..
dlfdllkkkgklseeeikkialqilegleylHsngiiHrDLKpeNiLldekgelkiaDFGlakkl.eksseklttlvgtreYmAPEvll....kakeytk

RCDVWSLGVTAIELSEGQPPLFHLPRDKALGEVLKQGPPTLKHADLWS
..|||||||. .|| .|..|. .  ....|  . |.  ..|..   .|
kvDvWslGvilyelltgklpfsgeseedqlelirkilkkkleedepks
0051082 (Phosphotyrosine protein) phosphatases II 1281-1490 4.3e-31 102.9 In-house 3-147 (151) alignment 
Range on Protein: 1281-1490
Range on HMM: 3-147/151.0
SDFINANWVRGFdgrqsYIATQGPKPntidHFWRMIIQHEVPLIIMATNLVEGDkiKCHRYWALFDgikgqekdpnllvtesgirvtteevaksrdfilr
||.||...| |.     .....|| .    .|.... .. .  |.. ....| .  .|..|.   .                                  
sdyinfsyvtgg.....lyrsggpla....dflellkelgiktivnlrseeerg..ycpeylpelg..................................

tfrlewndkeHFVKHLALNNWPDYGVPSSPRAVLRAIEVARDiryrNPGQPIVVHCSAGVGRTGILVAVDIGIDMllagrrVNLTSIVQHMREDRGGMLQ
          . |.|. . .|||.|.| |. |||...|...|    ....|..||||||.||||.|||... . .      |.| ......|. |.|. |
..........ievlhipildwpdpglplsfdavleflellld....kkngpvlvHCsaGkgRTGtlvalylmllg......vsleealeeyrlkrpgvvq

TFPQYEFAFK
.. |. | ..
pnqqflfqlf
subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 1252-1500 4.6e-30 99.2 In-house 40-273 (281) alignment 
Range on Protein: 1252-1500
Range on HMM: 40-273/281.0
LCRYKNIvPNMDtVVKIDPLFENNVKvENSDFINANWVRGFDGRQSYIATQGPKPNTIDHFWRMIIQHEVPLIIMATNLVEGDKIKCHRYWAlfdgikgq
  || || | .| . ...  ..   | . .|.| ||..|    .. || ||||| .|   ||||| | .   |.|  ...| .. ||  |.         
knrylni.pcld.isrvqlkvkmpnk.nstdyihanyirspflkrgyiltqgpkketradfwrmiwqenttaivmlcqfletnrekcaeyfp........

eKDPNLLVTESGIRVTTEEVAKSRDFILRTFRLEWNDKEHFVKHLALNNWPDYGVPSSPRAVLRaieVARDIRYRNpgQPIVVHCSAGVGRTGILVAVDI
 ..    .    . |. |. .  . ..   . | .. . ... |   ..|||. || |   .|.   . | || |    | |.||||||||.| |.||.|
.rnahcclqfdklsvsyedstvnkslvttrlnlsyegetrlithwlwkewpdwqvpessevmlk...ilrkirars..tppvihcsagvgrsgtlmavei

GIDMLLAGRR-VNLTSIVQHMRE-DRGGMLQTFPQYEFAFKAIGSFARLYG
 .. . .     ..  || |.|   |   .||. || . .| .  |   | 
alqsihshftlpdikqivshlrvtgraasvqtlqqymliwkvlldfgvayk
subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 1284-1498 5.7e-30 99.1 In-house 78-281 (301) alignment 
Range on Protein: 1284-1498
Range on HMM: 78-281/301.0
INANWVRGFDGRQSYIATQGPKPNTIDHFWRMIIQHEVPLIIMATNLVEGDKIKCHRYWALFDGikgqekdPNLLVTESGIRVTTEEVAKSRDFILRTFR
| |||.      . .|||||| .|| . || |..|..|  |.| .. ||  . ||. | ..  .        .| .    |.....|.  . . . ||..
ihanwiptsGhphrfiatqgPlkntsedfwamlvqydvekivmlgqkvekleekceeylpvkis.......ekldigrfkikiknkelilnkkiskrtle

LEWNDKE---HFVKHLALNNWPDYGVPSSPRAVLRAIEVARDIRyrnpgQPIVVHCSAGVGRTGILVAVDIGIDMLLAGRRVNLTSIVQHMREDRGGMLQ
.|   ..   . | |   ..|.|.||| |   .   .|.... .     .|||||||||.||.  ... ..    ..| ....||  ..|.||.|   .|
vedstgkfatrtvthyqysewtdrgvPkshaelfdlmelvkkse.....kPivvhcsaGiGrsvafigteylareveadptieltealkhlrehrwngvq

TFPQYefAFKAIGSFARL
|  |    .  .|.  ||
tnsql..ywmtlGtvyrl
subfamily_CG7180_pd Subfamily CG7180 1279-1491 7.3e-30 98.6 In-house 68-285 (296) alignment 
Range on Protein: 1279-1491
Range on HMM: 68-285/296.0
ENSDFINANWVRGFDGRQSYIATQGPKPNTIDHFWRMIIQHEVPLIIMATNLVEGDKiKCHRYWALFDGIKGQEKDPNLLVTESGIRVTTEEVAKSRDF-
|.||.||| .| .|   . || |..|| .|.| |||.. ..|.  ... |.  .  | ... ||      . .|   ... ...   ... ..   .   
eksdYinavyvdsflkkkeyivteapkketvdefWrlvydeeisavvvLtktfdfak.mypsywpnkskeqygeifveiveekqyanlkirtfkltkkiv

ILRTFRLEWNDKEHFVKHLALNNWPD-YGVPSSPRAVLRAIEVARDIRYRN----PGQPIVVHCSAGVGRTGILVAVDIGIDMLLAGRRVNLTSIVQHMR
 |   . . . ..  ||.. |  |.    ||.|  |..  .. .| .| ..      .|.||..| |..|.|. .|.|. ....    .|..   |. .|
alteqekqvkaetRivklfqlteWeledkvPlstnalielrrrvrlwrekvdedpeegPvvvvssdGasRsGvylaidanlelvekeeevdvFeavktlr

EDRGGMLQTFPQYEFAFKA
..| .....  .| . .  
rsRpqLvenveeYkyiYdv
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 1253-1497 1.6e-29 97.7 In-house 51-345 (350) alignment 
Range on Protein: 1253-1497
Range on HMM: 51-345/350.0
CRYKNIVPNMDTVVKID----PLFENNVKVENSDFINANWVRGF------DGRQSYIATQGPKPNTIDHFWRMIIQHEVPLIIMATNLVEGDKIKCHRYW
 |||||.|   . ||.     .    .  .. .|.||||...        .    |||||.| |.|.| |...|.. .|..|.. |..|| .  ||.|||
nrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvkvilsltsdvelnlekcyrYW

AL--FDG--IKGQEKDPNLLVTE------SGIRVTTE------EVAKSRDFILRTfRLEWNDK-EHFVKHLALNNWPDYGVPSSPRAVLRAIE-------
    .|.  .| ..|  |   ..      .... ..       .. . .|.   |  ..      . | .| ..||.| ..   |. .|.|.|       
qegsydditvklaskwenimgindsslysadvkkeasdndnisddndlkdnnslt.aitlaasdPyvvyqlqvknWkDlslllnPesilqalevkndlid

--VARDIRYRNPGQPIVVHCSAGVGRTGILVAVDIGID---MLL--AG----------RRVNLTSIVQHMREDRGGMLQTFPQYEFAFKAIGSFAR
  .|.     . ..||.|||||||||||.||..|  .    .|                |  .. ||...|. |  | |.  |. | ..|.  . .
dlfaeshldnarsspilvhCsaGvGrtGtlvtlDsllsdfeilenltkesrkldvaaktrDlisiivnelrkqrismvqnldqfifiYeallfyfa
0044763 (Phosphotyrosine protein) phosphatases II 1274-1487 1e-27 92.4 In-house 11-162 (178) alignment 
Range on Protein: 1274-1487
Range on HMM: 11-162/178.0
NNVKVENSDFINANWVRGFdgrqSYIATQGPkpntiDHFWRMIIQHEVPLIIMATNLVEGDKIKCHRYWALFDGikgqekdpnllvtesgirvtteevak
|   .| ||.|||... ..     |.....|      ...... .. . .|.. |. .|. ..||..||    |                          
nleglersdyinaseilpg....lylgslpp.....addlellkelgithivnlteelelgflkcdpywpeeag..........................

srdfilrtfrlewndkehfVKHLALnNWPDYGVPSSPRAVLRAIEVARDIRYrNPGQPIVVHCSAGVGRTGILVAVDIGIDMllagrRVNLTSIVQHMRE
                   ...| . ..||.|||.... .|...|  ....  ..| |..|||||||||.| ||| .. . .     ...| ......||
...................iqylhi.pipDhgvpdllehflefvefieeald.ekggpvlVHCsaGvgRsgtlvaaylmkkl.....glsleeaielvre

DRGgMLQTFPQYEF
 |  . ... |...
rRp.ivpnpgqlrq
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 1254-1492 1.1e-27 91.8 In-house 48-267 (288) alignment 
Range on Protein: 1254-1492
Range on HMM: 48-267/288.0
RYKNIVPNMDTVVKIDplfennvkvENSDF-INANWVRGFDGRQSYIATQGPKPNTIDHFWRMIIQHEVPLIIMATNLVEGDKIKCHRYWALFDGIKGQE
||.|.     | ||..         ...|| |.|| |     ..  | .| |   ||. .|.|... .|  |.| ..|.|  | |   |. .  | | . 
ryenlprcditrvkls.........ddpdfyiaanvvssakykrrlicaqaPlngtieelWkmllesdveyivmlcellekGkeksaeyfPsklGekari

KDPnllvtesG--IRVTTEEVAKSrdFILRTFRLEW-NDKEHFVKHLALNNWPDYGVPSSPRAVLRAIEVArdiryRNPGQPIVVHCSAGVGRTGILVAV
.            ...  ... |     . ..| .   ... .||.| |..|.| ||| .  . || .||      ..  .|||||.|||||||| |. .
grl.......ctvvkkkradidkl..vkvsllriskegeekvivkilhlleWdddgvPenylsplrllevl.....kslqkPivvhssaGvGrtgtlili

DIGIDMLLAGRRVNLTSIVQHMREDRGGMLQTFPQYEFAFKAI
 | ...|     . . |.....||.|   .||  || .... .
lialeslrlddflgirsllaklreerfkaiqtemqylyvhrcv
subfamily_ptpA1_pd Subfamily ptpA1 1250-1451 4.8e-27 89.7 In-house 48-251 (418) alignment 
Range on Protein: 1250-1451
Range on HMM: 48-251/418.0
AQLCRYKNIVPNMDTVVKIDPLFENnvkvENSDFINANWVRGFDGRQsYIATQGPKPNTIDHFWRMIIQHEVPLIIMATNLVEGDKIKCHRYWALFDGIK
.   || ||.|   | |..  . ..    | ||.||||.. |   .| .|.|||| ||||  ||||. .  . .|.| .   |  .||| |||    | .
tsknrytnilpvnhtrvqlkkiqdk....egsdyinanyidgaypkq.fictqgplpntiadfwrmvwenrcriivmlsresencrikcdrywpeqigge

GQEK--DPNLLVTESGIRVTTEEVAKSRDFILRTFRLEWNDKEHFVKHLALNNWPDYGVPSSP---RAVLRAIEVARD--IRYRNPGQPIVVHCSAGVGR
      . | ..    . .        |. | |  || .. . . . .   . |||. .|      | .|..|   ..  |   .   ||.|||||||||
qfsiygngnevfgtysvelveviqdpereiitrnirltfegetrditqyqyegwpdhnipdhtqpfrqllhsitnrqnqiipssdrnvpiivhcsagvgr

TGILVAVDI
|| ...  |
tgtfctavi
PTPc_DSPc_SM00012 1393-1492 5.1e-27 89.5 In-house 2-103 (105) alignment 
Range on Protein: 1393-1492
Range on HMM: 2-103/105.0
VKHLALNNWPDYGVPSSPRAVLRAIEVARDIRYRNP-GQPIVVHCSAGVGRTGILVAVDIGIDMLLAG-RRVNLTSIVQHMREDRGGMLQTFPQYEFAFK
|||.  ..||| |||... ..|....  .. .. .  ..|.||||||||||||..||.|| ...| .. ..|..  ||...|. | || ||. || |  .
vkhyhytgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqylflyr

AI
|.
al
subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 1282-1500 6.3e-27 89.1 In-house 68-280 (312) alignment 
Range on Protein: 1282-1500
Range on HMM: 68-280/312.0
DFINANWVRGFDGRQSYIATQGPKPNTIDHFWRMIIQHEVPLIIMATNLVEGDKIKCHRYWALFDGIKGQEKdpNLLVTESGIRVttEEVAKSRDFIL-R
 .| ||.|.     . ...||||  ||. |||.. .      ||. . .||    || .| .   |.   |     . ||.   .  |   ||.| |  |
fyihanfvkictkperfvctqgplentcthfwqlalslgstsiillcgfvedgsekcakyisdivgfvdled..hrvyteyctei..eiggkskdkithr

TF--RLEWNDKEHFVKHLALNNWPDYGVPSSPRAVLRAIEVARdiryrNPGQPIVVHCSAGVGRTGILVAVDIGIDMLLAGRRVNLTSIVQHMREDRGGM
 .   .    .|  ..|     |||.|.| |  . || .   .     .  .|.. |||||||||| |. ..  |  |   |. |.  .   .| ||   
vlkvvvkatgqesklnhyqwaswpdhgmpdscdtalrllsavk.....kdkkpviahcsagvgrtgtlaliesmiaalrhprkqnvkdsfvllrkdrars

LQTFPQYEFAFKAIGSFARLYG
...|||| .|....  |    |
vrvfpqyvyalrcvleflyskg
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 1277-1504 5.8e-26 86.1 In-house 53-265 (267) alignment 
Range on Protein: 1277-1504
Range on HMM: 53-265/267.0
KVENSDFINANWVRGFDGRQSYIATQGPKPNTIDHFWRMIIQHEVPLIIMATNLVEgDKIKchRYWAlfdGIKGQEKDPNLLVTESGIRvtTEEvaksRD
. .. ..||| .| |.  .. .|.||.|  ||| .|. .|....|| |.. |.  . |.|.  ..|       || |  . |. |  .    ||     |
rtkeeeyinasyvegyktknafivtqdplkntitdfltvihdqkvpvivlltkvft.dnir..lfwP...Pkmgqakkyqdltvehsle..kee....nd

FILRTFRLEWndKEHFVKHLALNNWPDYGVPSSPRAVLRAI-EVARDIRYRNPGQPIVVHCSAGVGRTGILVAVDIGIDMLLAGRRVNLTSIVQHMREDR
. . |. |..  |.   . ..|  .  . . .  .  |. .  .    .  | ..|.||.||.||||.| .. .|  .. .     ...   ....|. |
yqiitlelkf..knesahnvtlyyykkwnintnnkpylkplfgilaknqlengnrPlvvacsdGvGrsGtflvidsqleraktegvsdifdflrkirsqr

GGMLQTFPQYEFAFKAIGSFARlyGMLNH
 |...|  .| .  . .  .|.  |.|..
iglvdtkeryiyihellaeyae..grlke
subfamily_egg_pd Subfamily egg 1248-1497 9.7e-26 85.1 In-house 39-271 (307) alignment 
Range on Protein: 1248-1497
Range on HMM: 39-271/307.0
NAAQLCRYKNIVPNMDTVVKIdpLFENNVKVEnsDFINANWVRGFDGRQSYIATQGPKPNTIDHFWRMIIQHEVPLIIMATNLVEGDkiKCHRYWAlfdg
|  . .| | .  .  . ||.   ...   ..  ||| || |.|      .| .| |  || | ||||. | ||. |.| |  .| .  .|. ||     
nnlekarskrvhckdssrvkl..elrrGqyld..dfihanrvkGkpllnefilaqaplkntvddfwrmvfqeevqyivmltsrkese..rceyywp....

ikGQEKDPNLLVtESGIRVTTEEVAKSRDFILRTFRLE---WNDKEHFVKHLAlNNWPDYGVPSSPRAVLRAIevardiryRNPGQPIVVHCSAGVGRTG
    |.|.  .|   ..|... .| .  | ..|  .|     .|.| |..|    ..   .   ||  ||| .        ||  .|.||..  || ...
..kaesdslvtv.pGslrienlkvdskadplfrvtklklvGgddeerflehwq.gdvnnssdvysplrvlrkl........rnlskpvvvqdilGvskaa

ILVAVDIGIDMLLAGR--RVNLTSIVQHMREDRGGMLQTFPQYEFAFKAIGSFAR
 |||..| .  || |   .  .   |. .|  |   ...  .| | .. .  | |
tlvaieiallsllrGpitkslvlravvflrlrrrlsvesvllylfvyrlvlfffr
subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 1272-1490 1.3e-25 85.0 In-house 48-264 (285) alignment 
Range on Protein: 1272-1490
Range on HMM: 48-264/285.0
FENNV--KVENSDFINANWVRGFDGRQ-SYIATQGPKPNTIDHFWRMIIQHEVPLIIMATNLVEGDKIKCHRYWALFDGIKGQEKDPNLLVTESGIRVTT
 |  |  |  . |.| |.|.|     | .||.|||| |.|.  ||.|| | ..  ..|   |.||   ||  |.    |   .    .. .||      .
eetrvvlknhdrdyihaswmrmpgkdqstyittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekcalyypeklgevvkfgkyeitlteckeeaia

EEVAKSrdfiLRTFRLE-WNDKEHFVKHLALNNWPDYGVPSSPRAVlraIEVARDIRYRNPG-QPIVVHCSAGVGRTGILVAVDIGIDMLLAGRRVNLTS
  . ..    |     |  . .  ...|. .  |||   |   | .   ||. . ..  ||  .||.||||||||||  .| .|     ..    ...  
gtilna....ltvintedasseplymnhvqvpwwpdqlapedarpm...ielykwvkkvnpkekpicvhcsagvgrtatfvgidyatirimenpniemld

IVQHMREDRGGMLQTFPQYEFAFK
||. ||  |   .|.. |. | . 
ivremramrfqavqshmqflflyv
subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 1302-1484 1.3e-25 84.5 In-house 97-276 (302) alignment 
Range on Protein: 1302-1484
Range on HMM: 97-276/302.0
QGPKPNTIDHFWRMIIQHEVPLIIMATNLVEGDKIKCHRYWAlfDGIKGQEKDPNLLVTESGIRVTTEEVAKSRDFILRTFRLEW---NDKE-HFVKHLA
  || .|.. .| .| |..| ...  ...||... ||  |..  | ..|. |  .  |.   ..   || .  ..| | |  ..    ..|  . |. ||
ivpkkstlekhwalieqynvaivvqlcsfvedeekkcaeyys..dkvggelkfgrytvktvsvktdleeftdkksfklytveiknekkkkkvkktvdila

LNNWPDYGVPSSPRAVLRAIEVARDirYRnpgQPIVVHCSAGVGRTGILVAVDIGIDMLLAGRRVNLTSIVQHMREDRGGMLQTFPQ
   |||.| |  . . |  .       |.   . ..||||||||||| |||.  ||.. .  .  .| |||. .|. | | .|.  |
fsawpdhGapkeaytaldilkfces..yk...knvlvhcsaGvGrtGtlvaikyGiqlcskkkvtdllsivlpvrqcryGavqdeqq
subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 1254-1492 5.3e-23 76.0 In-house 57-286 (310) alignment 
Range on Protein: 1254-1492
Range on HMM: 57-286/310.0
RYKNIVPNMDTVVKIDplfenNVKVENSDFINANWVRGFDGRQSYIATQGPKPNTIDHFWRMIIQHEVPLIIMATNLVEGDKIKCHRYWALFDGI--KGQ
|| ..|   .. ||.        |    |.| ||.|.    |...| .|||   ||  |||||.|     |..  . .|  . ||  ||  .      | 
rysdvvcldtsrvklk.....idksryedyihanyvktnylrstficsqgplqhtiidfwrmifqeraesilllckvgeegrpkcvgywpslgvtetygc

EKDPNLLVTESGIRVTTEEVAKSRDFILrTFRLEWNDKEHFVKHLALNNWPDYGVPSSPRAVLRAIEVArDIRYrnpgQPIVVHCSAGVGRTGILVAVDI
 .  ||  .   . .    |.   | .        | ||  |. .   |||| |||      .    .| ..|.     | |||||||..|....||...
irvtnlsesseefeicnlavtfvpdnvp.vdeqpanlkelrvslikwpnwpdrgvpdekchtvpqrlla.qvrh....gpcvvhcsagkdrlyvvvalkl

GIDMLLAGRRVNLTSIVQHMREDRGGMLQTFPQYEFAFKAI
 || |  | .|..  .. ... .|    ||  || .  .  
kidkldrglkvdaeevktellksraiciqtelqyliidrvr
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 1251-1415 5.3e-22 73.0 In-house 35-188 (297) alignment 
Range on Protein: 1251-1415
Range on HMM: 35-188/297.0
QLCRYKNIVPNMDTVVKIdplfenNVKVENSDFINANWVRGFDGRQ--SYIATQGPKPNTIDHFWRMIIQHEVPLIIMATNLVEGDKIKCHRYWALFDGi
.  ||..|.   || ||.         . ..|.|||..|   |  .   || .|||  .|.| ||... ...|  |.| ..| |. . ||  ||   .. 
rknryrdilatddtrvkl......lrviterdyinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmvaklqedGrdkcapywpsvvq.

kGQEKDPNLLVTEsgIRVTTEEvakSRDFILRTFRLEWNDKEHFVKHLALNNWPDYGVPSSPRAVLR
 .. | ....|    .  |..|       ||  ..| . ...  |.|    .|||.||||    . |
.erlkagdvvvef..lsstsde...fdrviltelqliyrsesrvvrhvqflswpdhGvpsdledlvr
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 1280-1458 4.7e-21 69.5 In-house 89-294 (349) alignment 
Range on Protein: 1280-1458
Range on HMM: 89-294/349.0
NSDFINANWVR--GFDGRQSYIATQGPKPNTIDHFWRMIIQHEVPLIIMATNLVEGDKIKCHRYWALFD--G--IKGQEKDPNLL-VTESGIRVT-TEEV
  |.||||...   ..  . ||||| | | |.| |...|.  .|.|..  ..  | .  ||..||   .  .  .| |.   .   |  .  ||   .. 
lddyinanylkltrisvekkyiatqaPlPstvddfykvillngvklvlsLnddkelslekcdiywqelsysnitvklqnsslyianvqGnslrvstvkdt

AKSRDFILRTFRLEWNDKEH----------FVKHLALNNWPDYGVPSSPRAVLRAIEVARDIRYR---------NPGQPIVVHCSAGVGRTGILVAVDIG
..  | . .   |. .|...           .  | . ||.| ..   | ..|.|.||  |.            .   ...|||||| ||||.|| .|. 
dndndnnkknCdlpddddddaillavekPyellqlqvknwldlslllnPisilqalevkndliddlfarlyldtdqlstllvhcsaGcGrtGvlvtldll

IDMLLA
...|  
lsilep
0048076 (Phosphotyrosine protein) phosphatases II 1382-1490 7.7e-21 69.7 In-house 36-137 (145) alignment 
Range on Protein: 1382-1490
Range on HMM: 36-137/145.0
FRLEWNDKEHFVKHLALNNWPDYGVPSSPRAVLRAIEVARDIRYRNpgQPIVVHCSAGVGRTGILVAVDIGIDmllagRRVNLTSIVQHMREDRGGMLQT
.  | .. |... ..   .|||.|||.... .|...|  .... ..   |..||||||||||| ||| .. .      ..|.| ......|. | |. ..
ltselellerlgiqylylpwpDhgvpdllellleflefieealkeg..gpvlVHCsaGvgRtgtlvaaylmll.....lgvsleealelvrsqrpgavpn

FPQYEFAFK
. |..| ..
pgqlrflye
subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 1280-1505 1.2e-20 68.9 In-house 45-266 (290) alignment 
Range on Protein: 1280-1505
Range on HMM: 45-266/290.0
NSDFINANWVRGFDGrQSYIATQGPKPN-------TIDHFWRMIIQHEVPLIIMATNLVEGDKI----KCHRYWAlfdgikgQEKDPNllVTESGIRVTT
|.|.| || |   .| .  |.|| |. .       || .|| |. | .|  ..|  .  | ..      | .|         .. . .  ..  |. |  
nddyiHAnrvtcpng.lrliltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCakYvp.......esvgee..lkfkgltvkC

EEVAKSRDFILRTFRLEWNDKEH-FVKHLALNNWPDYGVPSSPRAVLRAIEVardIRyrNPGQPIVVHCSAGVGRTGILVAVDIGIDMLL-AGRRVNLTS
 .  |  |.. |.  ....|.|.  |.|  |..| .  |. ... .| .|.    ..  . . |..|||  |. |  .| |...|  ..      |.|..
kskekeddvetRelvvkfddeeeftvtHsllkgWnklnvqedtktllsliqk...vk..asktpvivHcvdGiSrsAalaaiilgyQkiaetsgsvkled

IVQHMREDRGGMLQTFPqyEFAFKAIGSFARLYGMLNHL
... .|. |  ....    |.||   | . ..  .|.. 
vlkalrkqralaitsal..elafvdagivllaievldqf
0048179 (Phosphotyrosine protein) phosphatases II 1385-1488 1.6e-19 65.5 In-house 41-137 (144) alignment 
Range on Protein: 1385-1488
Range on HMM: 41-137/144.0
EWNDKEHFVKHLALNNWPDYGVPSSPRAVLRAIEVARDIRYrnPGQPIVVHCSAGVGRTGILVAVDigidmLLAGRRVNLTSIVQHMREDRGGMLQTFPQ
|... |... ..   .|||.|||...  .|...|  ....   .| |..||||||||||| ||| .     |.  ....| ......|. | |. ... |
epefleregiqylhlpwpDhgvpdllellleflefieeale..eggpvlVHCsaGvgRtgtlvaay.....lmkklglsleealalvrsrrpgavpnpgq

YEFA
..| 
lrfL
subfamily_CG42327_pd Subfamily CG42327 1232-1416 1.3e-17 58.4 In-house 11-186 (319) alignment 
Range on Protein: 1232-1416
Range on HMM: 11-186/319.0
FDALPLNLGNLADLPKNAAQLCRYKNIVPNMDTVVKIDplfeNNVKVENSDFINANWVRGFD-GRQSYIATQGPKPNTIDHFWRMIIQHEVPLIIMATNL
|. ||  . .  ..|  . .  |. |.||  .| |  .    .  . ... ...|..|||.|  . ||||.| .  ..   |||.. .     |. .|.|
frdlPqliaradevPvtskdksrvinvvPlPetrvvlq....rigdddkdeyldasyvrGyddapnsyiaaqvsledsssdfwrtvweqqsrvivqltdl

VEGDKIKCHRYWALFDGIKGQEKDPNLLVTESGIRVtTEEVAKSRdFILRtfRLEwNDKEHFVKHLALnNWPDYGVPSSPRAVLRA
 |    .| .|.   .. ....   ..|||  |  |  .. | |  ..|.  |.. ...   . |    .|.. .||....|..  
selGikvcaeylPtketldntslyGdilvtlkgrev.kdryaist.lllk..rvd.keesrelthywy.kwleaevPaeeaaliam
subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 1300-1492 3.9e-17 57.2 In-house 39-217 (255) alignment 
Range on Protein: 1300-1492
Range on HMM: 39-217/255.0
AtqgpkpnTIDHFWRMIIQHEVPLIIMATNLVEGDKIKCHRYWALfdgikgqEKDPNLLVTESGIRVTTeevaKSRDFILRTFRLEW----NDKEHFVKH
        |.|.|...|.| .   ..| ... | .. ||..|. |       |||  | ...  . .|      | | .||| ..        | | |||
l.......tvdkfyqtivqtktevvvmlcdfaeegvekcssyfpl.......ekdeklkladvnvtttk....ssadvvlrtleitstlgekkkthtvkh

LALNNWPDYGVPSSPRAVLRAIEVARDiryrnPgQPIVVHCSAGVGRTGILVAVDIGID-MLLAGR-----RVNLTSIVQHMREDRGGMLQTFPQYEFAF
   . |..   |  .| .|  . |.||       ...|||||.|.||.  .| ...    |... .      ..  |.....|. | . ..|  |  |..
ysykGWieknaPelareilnilkvvrd.....s.ksvvvhCstGiGrsaafvlaelvyqkmirsldttetveldylslleelrskrkraihtPlqlafsi

KAI
  .
lmv
subfamily_CG42327_pd Subfamily CG42327 1428-1497 1.1e-15 52.1 In-house 246-316 (319) alignment 
Range on Protein: 1428-1497
Range on HMM: 246-316/319.0
PGQPIVVHCSAGVGRTGILVAVDIGIDMLLAG-RRVNLTSIVQHMREDRGGMLQTFPQYEFAFKAIGSFAR
   |.||||| ||||||...| || |  |    | |..  .|...|.||.  ..|  |||| .| .  .|.
sqGPlvvhcsdGvGrtGlviasdiairsleeskrsvdiPqlvssvrrdrasavltkeqyefiykvlseyak
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 1365-1492 3.1e-15 50.4 In-house 63-190 (440) alignment 
Range on Protein: 1365-1492
Range on HMM: 63-190/440.0
RVTTEEVA--KSRDFILRTFRLEWNdkEHFVKHLALNNWPDYGVPSSPRAVLRAIEVARDIRYRNPGQPIVVHCSAGVGRTGILVAVDIGIDMLLAGRRV
||  |||    . |.|  ..    .   . .|.   . ||| |||     ||. |.   . . .    |..||||||.||||...|||  .       ..
rvmleevkgvpdsdyinasyingie..srtlkqyhyqgwpdkgvpkfagpvlkmiqdvnesqekagngpllvhcsagagrtgviiavdsilreakrsdqi

NLTSIVQHMREDRGGMLQTFPQYEFAFKAI
.. |... ||..|  |.||  || | ..|.
difsfinsmrnnrpqmvqtpeqyafvheav
Pkinase_Tyr Protein tyrosine kinase 118-235 6.6e-15 44.8 Pfam-A 108-221 (259) alignment 
Range on Protein: 118-235
Range on HMM: 108-221/259.0
LIKETLKAIVHMHVHHVMHRDIKGGNILLDDEYAVCLTDFDTAYPY-DPAEQATHFHAVGTPYWMAPEIAACDYpegyaYDERCDVWSLGVTAIELSE-G
.. .  |.. ... ....|||.   |.||...  | ..||  |    .  .. .. .|     |||||.          . .. |||| ||. .|. . |
falqiAkGmeyLeskklvHrdLaarNvLleenkvvkisDfGLardiekddyykkkekaklpvkWmapEslkekk.....ftsksDvWsfGvllwEiftlg

QPPLFHLPRDKALGEVlKQG
. |. .|.  ..| .. |.|
espypglsneevlekl.keg
subfamily_hpo-7_pd Subfamily hpo-7 1307-1490 4.9e-14 46.8 In-house 45-221 (263) alignment 
Range on Protein: 1307-1490
Range on HMM: 45-221/263.0
NTIDHFWRMIIQHEVPLIIMATNLVEGDKIKCHRYWALFDGIKGQEKDPNLLVTESGIrvttEEVAKSRDFILrTfrLEWNDKEHFVKHLALNNWPDYGV
.||| |...| | .   ..| ..  | .. || .|. |    | . .. |. .|..      . . |.....  |  |.   | | |||   . |..   
qtidkfyqtivqtktevvvmLcDfneegvekcssyfPlekdekqklanvnvcttkvqs....dvllktlells.t..lgeKkkthtvkhysykgWieknd

PSSPRAVLRAIEVARDIRyrnpgqPIVVHCSAGVGRTGILVAVDIGID-MLLAGR-----RVNLTSIVQHMREDRGGMLQTFPQYEFAFK
|  .| .|. ..|||. .      ..|||||.|.||.   . ...    |... .      ..  |.....|. | . ..|  |  |.. 
pelareilnilkvarnsk......slvvhcstGiGrsaafsvaElvyqkmirsldttstveldylsLleelrssrkraihtPmqLafsil
subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 1294-1490 1.3e-13 45.6 In-house 3-198 (199) alignment 
Range on Protein: 1294-1490
Range on HMM: 3-198/199.0
GRQSYIATQGPKPNTIDHFWRMIIQHEVPLIIMATNLVEGDKIKCHRYWALFDGikGQEKDPNLLVTESGIrvTTEEVAKSRDFILrTFRLEWNDKEHFV
|.. ||||| |  .|.  ||.|. .     |.|  .     .     ||.  .   |  |  .| ||   |  ||.       .|| |           .
gqrryiatqhplretmadfwqmvwetgsghivmvnddqknkeadypfywpttes..gtgkygslsvttkti..ttkpdytitalil.tnnttappstrei

KHLALNNWPDYGVPSSPRA---VLRAIEVARDIRyRNPGQPIVVHCSAGVGRTGILVAVDIGIDMLLAGR--RVNLTSIVQHMREDRGGMLQTFPQYEFA
 |  .  | .   |        |. . ||..    ..   |..|||| | | ||..||.|||.      .   |.|  . . .|. | |.. ....|.| 
shyqftswkekttpnvalfvgfvvasrevskkye.qekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfi

FK
..
yq
subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 1258-1513 1.7e-13 44.9 In-house 44-296 (303) alignment 
Range on Protein: 1258-1513
Range on HMM: 44-296/303.0
IVPNMDTVVK--IDPLFENNVKVENSDFINANWVRgFDGRQSYIATQGPKPNTIDHFWRMIIQHEVPLIIMATNLVEGDKIKCHRywaLFdgikGQEKDp
.| |||      .  |   .||. .| .| |...  .| ..  | || | . |   ||.|||.  |  ...     | ||.  .    .|     ...| 
fvknmdknrfvdvicldhskvklsdssyihasyle.ldsskkailtqlplshtaadfwqmiieqkvkcvlllltdseydklggds...vf....prnqd.

NLLVTESGIRVTT-EEVAKSRDFILRTFRLEWNDKEHFVKHLALNNWPDYGVPSS--PRAVLRAIEVARDIRYRNPGQPIVVHCSAGVGRTGILVAVDIG
 |   |  |||    .|  .  . |.   .   |   |..    ..||   .||   |. | .  ..   .|   ...| |    .|.||.| .   .  
flkfeersirvgefkrvelgdgwvlkvlsvsngdyksflhvhhykawphnsipsdgspkfvkqiwqlqsvlrkysdstptvymslsgcgragtfalfeta

iDMLLA--GRRVNLTSIVQHMREDRGGMLQTFPQYEFAFKAIGSFARLYGMLNHLLSVQGDEE
  . |      ..|   .. .|. |   .| . |. . .  .       |. .  .. . ..|
.hlslhseqasldlvkclenvrngrlhavqnlsqfsvvytllaehvldngicklaipkkpnde
subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 1294-1490 1.7e-13 45.2 In-house 2-197 (198) alignment 
Range on Protein: 1294-1490
Range on HMM: 2-197/198.0
GRQSYIATQGPKPNTIDHFWRMIIQHEVPLIIMATNLVEGDKIKCHRYWALFDGikGQEKDPNLLVTESGIrvTTEEVAKSRDFILrTFRLEWNDKEHFV
|.. ||||| |  .|.  ||.|. .     |.|  .     .     ||.  .   |  |  .| ||   |  ||.       .|| |           .
gqrryiatqhplretladfwqmvwetgsghivmvnddqknkeadypfywpttes..gtgkygslsvttkti..ttkpdytitalil.tnnttappstrei

KHLALNNWPDYGVPSSPRA---VLRAIEVARDIRyRNPGQPIVVHCSAGVGRTGILVAVDIGIDMLLAGR--RVNLTSIVQHMREDRGGMLQTFPQYEFA
 |  .  | .   |        |. . ||..    ..   |..|||| | | ||..||.|||.      .   |.|  . . .|. | |.. ....|.| 
shyqftswkekttpnvalfvgfvvasrevskkye.qekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfi

FK
..
yq
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 1430-1492 1e-12 42.6 In-house 229-291 (297) alignment 
Range on Protein: 1430-1492
Range on HMM: 229-291/297.0
QPIVVHCSAGVGRTGILVAVDIGIDMLLAGRRVNLTSIVQHMREDRGGMLQTFPQYEFAFKAI
 ...|||||||||.|..|  |. ...|  .|  . ..|....|| |  ..||. |.|. ..|.
ayllvhcsaGvGrsGvvvlsdvilaklrkkripdvaailsilreqrarlvqtleqfellydav
0038934 (Phosphotyrosine protein) phosphatases II 1398-1491 4e-12 41.7 In-house 84-172 (194) alignment 
Range on Protein: 1398-1491
Range on HMM: 84-172/194.0
LNNWPDYGVPSSPRAVLRAIEVARDIRYRNPGQPIVVHCSAGVGRTGILVAVdigidMLLAGRRVNLTSIVQHMREDRGGMLQTFPQYEFAFKA
   .||.|.. |   .|| .... ..  ..||. ..||| ||.||||.|||       |.  .. ..   ....|| |.|....  ..|  .| 
klpfpddgtvPsleillrfldlvdeflnedpggvvaVHCkaGlgRtGtlvaa.....YLiyrlgmsaeeAialfrekRpgaipnqdyleallkr
subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 1398-1493 4.4e-09 30.2 In-house 188-282 (302) alignment 
Range on Protein: 1398-1493
Range on HMM: 188-282/302.0
LNNWPDYGVPSSpraVLRAIEVARDI--RYRNPGQPIVVHCSAGVGRTGILVAVDIGIDMLLAGRRVNLTSIVQHMREDRGGMLQTFPQYEFAFKAIG
|.||..  || .   . ..|. | ..  .  .  ...|.    |.|| |..... . .. | .|  .| . ||. .|..|  ..... || . . |. 
ltnWkqkkvpvk...yaeliktaakvfakkikadentvivSknGaGRagafltlavaveklqkgkepnikeivksiRsqRpravdslkQyvslyiall
PTEN_1 1400-1448 2.3e-08 29.1 In-house 101-149 (196) alignment 
Range on Protein: 1400-1448
Range on HMM: 101-149/196.0
NWPDYGVPSSPRAVLRAIEVARDIRYRNPGQPIVVHCSAGVGRTGILVA
 ..|.|.||  .    . ...  .. ...|  ..||| ||.||.| .||
pieDhgapslselfdicksfiewllsdpngnvVlVHCkaGlgRsGtvva
subfamily_eak_pd Subfamily eak 1261-1471 3.4e-08 27.3 In-house 56-277 (332) alignment 
Range on Protein: 1261-1471
Range on HMM: 56-277/332.0
NmdtVVKIDPLFENNVKVE-----NSDFINANWVRGFDGRQSYIATQGPKPNTIDHFWRMIIQHEVPLIIMATNLVEGDKIKCHRYWAlfdgIKGQEKdp
|   |||| |   ..|..      .  .|||  .   .  . || |  .. . .  ||.|...   | |..  . || .  |  .|.      |..|.  
n...vvkivpydrylvrltssqlnrlGyinaslaefsevGrkyiltGiasedkvfafwqmvleqkspaivqlledvelkleksdkyfp....dktree..

nllVTESGIRVTTEEVAKSRDFILRTFRLEWNDKEHFVKHLALNNWPDYGVPSSP-----RAVLRAIEVAR--------------DIRYRNPGQPIVVHC
   .    . |.. |  |   .  | . |.  .. | |.|  .  | .. .|        | |.. . |                   .  |    .. .
...lkfGildverkefvkrniletrllelskGnethrvlhykvfGwtettlpkyedflalrkvmkevGvlllivmksallsstlkkyihtppsfapiiqs

SAGVGRTGILVAVDIGIDMlLAGRRVNLTSIVQHM
. |  |.|..| .|. | . . ... || |. . .
arGsaraGvfvvidllirl.idnkkknlysvedli
subfamily_PTPDC1_pd Subfamily PTPDC1 1399-1486 1.5e-07 26.1 In-house 88-166 (182) alignment 
Range on Protein: 1399-1486
Range on HMM: 88-166/182.0
NNWPDYGVPSsPRAVLRAIEVARDIRYRnpGqPIVVHCSAGVGRTGILVAVdigidMLLAGRRVNLTSIVQHMREDRGGMLQTFPQYE
  |.||||.|  . .|  . |.     .  |  . ||| || ||||.|.|.     .|.  .|..    .. .|. |   .||  | |
fgwkDygvas.leriLdivkvvafalqe..g.kvavhChaGlGrtGvliac.....ylvyakrltaekaiklvrskrpksiqtreqve
subfamily_Sponge-PTP-7_pd Subfamily Sponge-PTP-7 1432-1491 8.5e-07 23.3 In-house 1-60 (69) alignment 
Range on Protein: 1432-1491
Range on HMM: 1-60/69.0
IVVHCSAGVGRTGILVAVDIGIDMLLAGRRVNLTSIVQHMREDRGGMLQTFPQYEFAFKA
.|||||.| |||| ..|. . .  . . . |..   ||.||  |  |.    .| |   |
mvvhcssgtgrtgtfiaimvemarikseklvdifnnvqymrkcrpmmvmneieyifihda
subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 1254-1328 1.6e-06 21.9 In-house 42-117 (347) alignment 
Range on Protein: 1254-1328
Range on HMM: 42-117/347.0
RYKNIVPNMDTVVKIDPLFENNVKVENS-DFINANWVRGFDGRQSYIATQGPKPNTIDHFWRMIIQHEVPLIIMAT
| |.   . .| | . |   .| . ...  .|||  ..  . .. || || | |.|.  ||.|.    |  ..   
rskdvklidatrvvlspeksknsraddvetyinashikfdnaskeyiltqyplpdtvrdfwkmvsvtkvtqvvtif
subfamily_Sponge-PTP7_pd Subfamily Sponge-PTP7 1433-1492 1.6e-06 22.4 In-house 1-60 (69) alignment 
Range on Protein: 1433-1492
Range on HMM: 1-60/69.0
VVHCSAGVGRTGILVAVDIGIDMLLAGRRVNLTSIVQHMREDRGGMLQTFPQYEFAFKAI
|||||.| |||| ..|. . .  . . . |..   ||.||  |  |.    .| |   |.
vvhcssGtGrtGtfiaimvemarikseklvdifnnvqymrkcrpmmvmneneymfihdal
IQ IQ calmodulin-binding motif 1918-1933 1.8e-06 16.9 Pfam-A 2-17 (21) alignment 
Range on Protein: 1918-1933
Range on HMM: 2-17/21.0
AAAIRIQAAFRGYRAR
.|||.||||.|||.||
kaaikIQaawRgylaR
subfamily_PRL_pd Subfamily PRL 1401-1479 9.1e-06 19.8 In-house 61-134 (151) alignment 
Range on Protein: 1401-1479
Range on HMM: 61-134/151.0
WP-DYGVPSSPRAVLRAIEVARDIRYRNPGQPIVVHCSAGVGRTGILVAVDigidMLLAGrrVNLTSIVQHMREDRGGML
.. | | . .   | . .|. ..   ..|.. . ||| ||.||. .|||.     .. ||  ..    |. .|| | | .
lafddGavPpeevveeWlellkekfkeepkstvavhcvaGlGraPvlvala....lieaG..mkyedavefirekrrgai