Gene MbrePTP-Un-7 in Monosiga brevicollis

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily PTP-unclassified
Protein sequence
ID Type Fasta BLAST phosphatome Note
MbreP061_AA protein Get Run
MbreP061_AA_4-253 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_PTPRD_pd Subfamily PTPRD 3-253 6.5e-90 297.4 In-house 37-277 (564) alignment 
Range on Protein: 3-253
Range on HMM: 37-277/564.0
QHSANASRAAVNARKQRYRDIVAYDHTRVSLAAAGGHLGSDYINANYVVGYEKERAYIASQGPLPDTVGDFWRMAWEQTSRTIVMVAQVRENNRVKCELY
|.. .|... .| .| || .||||||.|| | .  |. |||||||... ||.|..||||.||||..|. ||||| ||| |.||||. ...|...|||. |
qftweaankpaNkaKNRyanivaYdhsRVvLskvegdegsDYINAsfidgyrkrkayIAtqgPlaetiedFWRmvweqnsstiVmltkleEkgkvkchkY

WPAVDhSATYGPLMVYGRREEVLSpNVTRRLFEIHHQDEDRVQEVVHLQMTTWPDHGSPRNPEAFLELHRRFREAQRnarnSRSGPVglpIVHCSAGVGR
||. . ..||| |.|    || |. ... | |........ ..|| . . | ||||| | .....|.| |. |....    . .||.   .|||||||||
WPekg.tetygeltVtleeeeela.dyeirtfklkkkkssesreVrqFhFtsWPdhgvpesatslLdlirkvralne....pdagPi...vVhCSaGVGR

SGTFICLDTVFETLLAgRDPVEPLAIISRLRNCRNFMVQAVDQLDFIFRAI
.|||| .| . | . .  . |.   ....||. ||.|||  .|  ||..||
TGtfividamlerike.ektvDiyqyvkalrkqRnamVqteeQYiFiheai
0051299 (Phosphotyrosine protein) phosphatases II 6-253 7.9e-82 270.2 In-house 41-282 (288) alignment 
Range on Protein: 6-253
Range on HMM: 41-282/288.0
ANASRAAVNARKQRYRDIVAYDHTRVSLAAAGGHLGSDYINANYVVGYEKERAYIASQGPLPDTVGDFWRMAWEQTSRTIVMVAQVRENNRVKCELYWPA
 .|..   |  | ||.||..|||.|| |   .|. |||||||.|. ||...|..|| |||||.||.||||| ||| .|.|||. .. |..|.||. ||| 
lsaallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyidgynlkrkfIatqgPlpntvedFWrmvweqnvrvIvmltklvelgrekcaqYwpl

vDHSATYGPLMVYGRREEVlSPNVTRRLFEIHHQ----DEDRVQEVVHLQMTTWPDHGSPRNPEAFLELHRRFREAQRnarnsrsGPVGLPIVHCSAGVG
 ..| |||...|. ..|||  ...| | .|. .      .. ...| |...|.||||| | .||..|.. |..|.|..        . |  .||||||||
.ggsltygditvtllseev.lddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpdspellldflrlvrkala.......sgggpvvVHCsaGvg

RSGTFICLDTVFETLLAGrDPVEPLAIISRLRNCRNFMVQAVDQLDFIFRAI
|.||||.||...| |...   |..| .. |||..|..||| ..|. |...|.
Rtgtfialdllleqleke.ggvdvleavkrlreqRpgmvqtpeqyrfvyeal
0050432 (Phosphotyrosine protein) phosphatases II 8-253 2.4e-81 268.7 In-house 62-295 (308) alignment 
Range on Protein: 8-253
Range on HMM: 62-295/308.0
ASRAAVNARKQRYRDIVAYDHTRVSLaaaggHLGSDYINANYVVGY--EKERAYIASQGPLPDTVGDFWRMAWEQTSRTIVMVAQVRENNRVKCELYWPA
...   |  | ||.||..|||.|| |     . |||||||.|| ||   ..|..|| |||||.||.||||| ||| .|.|||. .  ||.|.||. ||| 
vallpenkdkNrykdilpydhsRVkl.....degsdYInAsyvdgyssklprkfIatqgPlpntvedFwrmvweqnvrvIvmLtklvengrekcaqYwpl

V--DHSATYGPLMVYGRREEVlSPNVTRRLFEIHHQDEDRVQEVVHLQMTTWPDHGSPRNPEAFLELHRRFREAQRNarnsrsgpvGLPIVHCSAGVGRS
   ..| .||.. |. ..|||  ...|.| .|. . ... . .| |...|.||||| | .||..|.. .. |. ...         |  .|||||||||.
elgggsleygkftvtllseev.lddytvrtleltnlgdgesrtvthfhytnWpdhgvPpspeilldflelvrkslpg.........gpivVHCsaGvGRt

GTFICLDTVFETLLAGrDPVEPLAIISRLRNCRNFMVQAVDQLDFIFRAI
||||.||...| | ..   | .. .. .|| .|..||| ..|. |..||.
Gtfialdllleqleke.ggvdvfeavkklReqRpgmvqtpeqylflyral
0046845 (Phosphotyrosine protein) phosphatases II 5-252 5.5e-81 267.3 In-house 19-269 (284) alignment 
Range on Protein: 5-252
Range on HMM: 19-269/284.0
SANASRAAVNARKQRYRDIVAYDHTRVSLAAAGGH-LGSDYINANYVVGY-----EKERAYIASQGPLPDTVGDFWRMAWEQTSRTIVMVAQVRENNRVK
| .....  |  | ||.||..|||.|| |   .|.  .||||||.|| ||      .....|| |||||.||.||||| ||| .|.|||. .  ||.|.|
slsvallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweqnvrvIVmltelvengrek

CELYWPAVDHSATYGPLMVYGRREEVlSPNVTRRLFEIHHQD-EDRVQEVVHLQMTTWPDHGSPRNPEAFLELHRRFREAQRNarnsrSGPVGLPIVHCS
|. |||  ... |||...|. ..|||  ...|.| .|. . . .. . .| |...|.||||| | .|| .||. |  ||...|     ... |  .||||
caqYwplegevltygdftvtllseev.kddytvrtleltnlgytgesrtvthfhytswpdhgvppspedlleflrlvrellen.....lpgggpivVHCs

AGVGRSGTFICLDTVFETLLAGRD--PVEPLAIISRLRNCRNFMVQAVDQLDFIFRA
|||||.||||.||...| | ....   | .| ...|||..|..||| ..|. |...|
aGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyea
subfamily_PTPRB_pd Subfamily PTPRB 1-252 6e-80 263.4 In-house 38-280 (293) alignment 
Range on Protein: 1-252
Range on HMM: 38-280/293.0
GRQHSANASRAAVNARKQRYRDIVAYDHTRVSLAAAGGHLGSDYINANYVVGYEKERAYIASQGPLPDTVGDFWRMAWEQTSRTIVMVAQVRENNRVKCE
|.... .|...|||. |.||..|..|||.|| |||  .. |||||||||. ||. .| .||.|||||.|| ||||| ||. |..|||. |. |. .||||
gkdqavkaaelavnraknrytnilpydhsrvkLaalkdesgsDYinanyipgynsprefiatqGPlpetvddfWrmvwekkssiivmltqlvekgkvkCe

LYWPAVDHSATYGPLMVYGRREEVLSpNVTRRLFEIHHqdEDRVQEVVHLQMTTWPDHGSPRNPEAFLELHRRFREAQRNarNSRSGPVglpIVHCSAGV
 |||| ... .|| . |    ||.|. . . | ..|..  |.. ..| ... |.||||| | .....|.. |..|||...  .....|.   .|||||||
eYWPadeepvlyGdikvtlvaeeele.dwvirelkiek..ekeerkvrqyhftsWpdhgvPektktlldfvrtvreaiek..taskrPi...vvhCsaGv

GRSGTFICLDTVFETLLAgRDPVEPLAIISRLRNCRNFMVQAVDQLDFIFRA
||.||||.||......   .| |. ..|...||. ||..||...|  || ..
GRtGtfialdrllqaiee.edyvdifgivaelReeRnllvqtekqYifihqc
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 2-253 5e-79 260.3 In-house 29-272 (281) alignment 
Range on Protein: 2-253
Range on HMM: 29-272/281.0
RQHSANASRAAVNARKQRYRDIVAYDHTRVSLAAAGGHLGSDYINANYVVGYEKERAYIASQGPLPDTVGDFWRMAWEQTSRTIVMVAQVRENNRVKCEL
....|.||.|  |  |.||..|||||.||| ..    .  .||||||.| ||..|..|||.|||.|... .||.| |||. ..||||..  |....||  
vdntataskadenvlknrYsnivaYDatrvkvtpneenkntDYinanfvpgykgekeyiatqgPvPaslvafWqmvweqkvsaivmvtreieagklkChr

YWPAVDHSATYGPLMVYGRREEVlSPNVTRRLFEIhHQDEDRVQEVVHLQMTTWPDHGSPRNPEAFLELHRRFREAQRNARNsrsgpvGLPIVHCSAGVG
|||  ... .|| ..|   .||  ...  .| |.. ....   .||..|. |.||||| | .....|| ..  ...... ..         ..|||||||
YWPddnselkygdvtvkstaeee.katyierkfkl.eresgetreveqlaytaWPdhGvPattkellefrkevlkltekktk......aplvihCsaGvG

RSGTFICLDTVFETLLAGRDPVEPLAIISRLRNCRNFMVQAVDQLDFIFRAI
|.||.| ||...... | . .... |..  ||. ||.|||.| | .|...|.
rtGtyialDrlvkaveaeleeldvkavvaelrkernlmvqtvvqyefvykav
0040438 (Phosphotyrosine protein) phosphatases II 7-252 8.6e-78 257.1 In-house 36-271 (317) alignment 
Range on Protein: 7-252
Range on HMM: 36-271/317.0
NASRAAVNARKQRYRDIVAYDHTRVSLAAAGGHLGSDYINANYVVGYEKERAYIASQGPLPDTVGDFWRMAWEQTSRTIVMVAQVRENNRVKCELYWPAv
. ..  .|  | ||.||. |||.|| |   ||.|.||||||.|| |... |..|| |||||.||.||||| ||| ...|||. .  |..|.||. |||  
svaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyvdgpnlkrkfIatqgPlpntvedFwrmvweqgvtvivmLteleelgrekcaqYwpl.

DHSATYGPLMVYGRREEVlSPNVTRRLFEIHHQDEDRVQEVVHLQMTTWPDHGSPRNPEAFLELHRRFREAQRnarnsrsGPVGLPIVHCSAGVGRSGTF
... |||...|  . ||.  ...| | .|. . ... . .| |...|.||||| | .|. .|.. .. |||..       .| |  .|||||||||.|||
getltygdftvtllseee.lagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfleavreale.......dpggpvlVHCsaGvgRtGtf

ICLDTVFETLLAGRdPVEPLAIISRLRNCRNFMVQAVDQLDFIFRA
|......| |  ..  | .  .. .||..|. .||  .|. |. .|
iaaylmleqlekeg.gvdveeavkelreqRpgavqtpeqyrflyda
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 6-253 1.9e-77 255.4 In-house 38-276 (318) alignment 
Range on Protein: 6-253
Range on HMM: 38-276/318.0
ANASRAAVNARKQRYRDIVAYDHTRVSLAAAGGHLGSDYINANYVVGYEKERAYIASQGPLPDTVGDFWRMAWEQTSRTIVMVAQVRENNRVKCELYWPA
.  |   ||..| || .|.||||||| |    |. |||||||||. ||....||||.|.|||.|. ||||| ||| |..|||..|..|. ..|.. ||| 
slkslepvnkaknryanilaydhtrvkLqmlegeegsDyinanyidGyrrkkayiaaqaPlpetieDfWrmvWeqnsavivmltqeeergkakvhryWPs

vDHSATYGPLMVYGRREEVLSPNVTrRLFEIHHQDEDRVQEVVHLQMTTWPDHGSPRNPEAFLELHRRFREAQRNarnSRSGPVglpIVHCSAGVGRSGT
 . | .|| |.|  . |  ||  |  | |......|. ...|   ..|.|||.|.| ..  .|.| |. ..||..   |  ||.   .||||||||| |.
.kgsrsygklvvelkeevelsdyvl.refkvtrteeeesrqvrqyhytsWpdegvpesgaslldlvrqvskaqqk...sgagpi...vvhCsaGvGrtGv

FICLDTVFETLLAgRDPVEPLAIISRLRNCRNFMVQAVDQLDFIFRAI
|| .|.. | . |    |. . ....||. || |||. || .||. ..
fiavdillerika.ealvDvfqtvkqlreqrnlmvqtedqyefiydvl
0036941 (Phosphotyrosine protein) phosphatases II 10-252 3.4e-77 255.0 In-house 35-272 (297) alignment 
Range on Protein: 10-252
Range on HMM: 35-272/297.0
RAAVNARKQRYRDIVAYDHTRVSLaaagGHLGSDYINANYVVGYEKERAYIASQGPLPDTVGDFWRMAWEQTSRTIVMVAQVRENNRVKCELYWPAV-DH
.   |  |.||.||..|||||| |    .. |||||||.|| ||. .|..|| |||||.||.||||| ||| ...|||. .. |..|.||. |||   ..
llpenleknRykdilpydhtRVkl....ddegsdYinAsyvdgydlkrkfIatqgPlpntvedFWrmvweqnvtvIvmltelvelgrekcaqywpleege

SATYGPLMVYGRREEV-LSPNVTRRLFEIHHQDEDRVQEVVHLQMTTWPDHGSPRNPEAFLELHRRFREAQRNARNSrsgpvGLPIVHCSAGVGRSGTFI
| |||...|  ...|| |....|.| .|. . ... . .| |...|.||||| | .|. .|.. ...|.........     |  .||||||||||||||
sltygdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfielvrkvlkllpsg.....gpvlVHCsaGvgRsgtfi

CLDTVFETLLA--GRDPVEPLAIISRLRNCRNFMVQAVDQLDFIFRA
..|.... |     .  | .| ..  ||..|...|| ..|. |. .|
aadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyea
0047943 (Phosphotyrosine protein) phosphatases II 7-252 1.8e-76 252.5 In-house 31-267 (273) alignment 
Range on Protein: 7-252
Range on HMM: 31-267/273.0
NASRAAVNARKQRYRDIVAYDHTRVSLaaagGHLGSDYINANYVVGYEKERAYIASQGPLPDTVGDFWRMAWEQTSRTIVMVAQVRENNRVKCELYWPAV
....   |  | ||.||..|||.|| |    |. |||||||.|| ||...|..|| |||||.||.||||| ||| .|.|||. .. |..|.||. |||  
svallpenkdknrykdilpydhsrvkl....gdggsdyinAsyvdgynlkrkfiatqgPlpntvedfwrmvweqnvrviVmLtelvelgrekcaqYwple

DH--SATYGPLMVYGRREEVlSPNVTRRLFEIHHQDEDRVQEVVHLQMTTWPDHGSPRNPEAFLELHRRFREAQRNARNSrsgpvGLPIVHCSAGVGRSG
    | |||.. |. ..||.  ...| | .|. . . . . .| |...|.||||| | ..| .||. .  |.|.......     |  .|||||||||.|
ggelsltygkftvtllseet.kddytvrtleltnlgtgesrtvthfhytgwpdhgvppslesllefielvrkalealpsn.....gpvvVHCsaGvgRtg

TFICLDTVFETLLAGrDPVEPLAIISRLRNCRNFMVQAVDQLDFIFRA
|||.||.... | ..   | .| .. .||..|  ||| ..|. |. .|
tfialdllldqleke.ggvdvleavkllrsqRpgmvqtpeqyrflyea
0043336 (Phosphotyrosine protein) phosphatases II 9-252 1.6e-75 249.4 In-house 40-272 (278) alignment 
Range on Protein: 9-252
Range on HMM: 40-272/278.0
SRAAVNARKQRYRDIVAYDHTRVSLAAAGGHLGSDYINANYVVGYEKERAYIASQGPLPDTVGDFWRMAWEQTSRTIVMVAQVRENNRVKCELYWPavDH
..   |  | ||.||..|||.|| |   ||.|.||||||.|| ||.. |..||.|||||.||.||||| ||. ..||||. .  |..||||  |||  ..
allpenkdknrykdilpydhsrvklsllggdldsdYinAsyvdgynvprkfiatqgPlpetvedFwrmvwelgvttivmLtelvelgrvkcaqYwp..gg

SATYGPLMVYGRREEVlSPNVTRRLFEIHHQDEDRVQEVVHLQMTTWPDHGSPRNPEAFLELHRRFREAQRnarnSRSgpvGLPIVHCSAGVGRSGTFIC
| |||.. |. ..||.  ...|.| .|...  .. ...|.|.. . ||||| | ... .|.. ...|||..    ...   |  .|||||||||.||||.
sltygdftvtllkeeh.lddytvrtlevtnlgdgesrtvthyhylgwpdhgvpeslsllldflkavreale....dsn...gpvlVHCsaGvgRTGtfia

LDTVFETLLAGRdPVEPLAIISRLRNCRNFMVQAVDQLDFIFRA
|....| |  ..  | .. ....||..|  .||  .|. |...|
lyllleqlekeg.gvdleeavkelreqRpgavqtpsqyrflyea
0045450 (Phosphotyrosine protein) phosphatases II 8-252 6.7e-74 244.7 In-house 49-299 (307) alignment 
Range on Protein: 8-252
Range on HMM: 49-299/307.0
ASRAAVNARKQRYRDIVAYDHTRVSLAAAGGH-LGSDYINANYV--------VGYEKERAYIASQGPLPDTVGDFWRMAWEQTSRTIVMVAQVRENNRVK
...  .|  | ||.||..|||||| |   .|.  .||||||.||         || . |..|| |||||.|| ||||| ||| ...|||. .  |..|.|
iallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydlkrkfIatqgPlpetvedFwrmlweqgvtvivmltelvelgrek

CELYWPAVDHSATYGPLMVYGRREEVlSPNVTRRLFEIHHQ-DEDRVQEVVHLQMTTWPDHGSPRNPEAFLELHRRFREAQRNARNSrsgpvGLPIVHCS
|  |||  ... |||.. |. ..||.  ...|.| .|...   .. . .| |...|.||||| | ..| .|.. .. |.|... ...     |  .||||
caqywPdegeeltygnftvtllseeh.ldgytvrtlevtdldgtgesrtvthfhytgwpdhgvppsfeelldfieevrkaleelpkg.....gpvlVHCs

AGVGRSGTFICLDTVFETLLAGRDP--VEPLAIISRLRNCRNFMVQAVDQLDFIFRA
|||||.||||..... . | ..     | .| ....||..|  .||  .|. |. .|
aGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyea
Y_phosphatase Protein-tyrosine phosphatase 14-253 9.5e-73 239.8 Pfam-A 1-233 (235) alignment 
Range on Protein: 14-253
Range on HMM: 1-233/235.0
NARKQRYRDIVAYDHTRVSLaaAGGHLGSDYINANYVVGYEKERAYIASQGPLPDTVGDFWRMAWEQTSRTIVMVAQVRENNRVKCELYWP-AVDHSATY
| .|.||.||..||.||| |   |    ||||||||| ||......||.||||..|..||||| |.. ...|||.... |..|.||. ||| . . | ||
nkkknRykdilpydktrvkl..kgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeeslty

GPLMVYGR-REEVLSPNVTRRLFEIHHQDED-RVQEVVHLQMTTWPDHGSPRNPEAFLELHRRFREAQrnarNSRSGPVglpIVHCSAGVGRSGTFICLD
| . |  . .|.  . ..| | .|.....|. . .|| .|..|.||||| |..|...|.| |.... .    ...||||   .|||||||||.|||..||
gdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkveksk....eaksgpv...vVhCsaGvgRtgtfvald

TVFETLLAGRDpVEPLAIISRLRNCRNFMVQAVDQLDFIFRAI
...| | |... |. | |...||..|. ||| ..|. |. .||
illeqleaeee.vdvlqivkelRkqRpgmvqsleqYiflykai
Y_phosphatase Protein-tyrosine phosphatase 14-253 9.5e-73 239.8 In-house 1-233 (235) alignment 
Range on Protein: 14-253
Range on HMM: 1-233/235.0
NARKQRYRDIVAYDHTRVSLaaAGGHLGSDYINANYVVGYEKERAYIASQGPLPDTVGDFWRMAWEQTSRTIVMVAQVRENNRVKCELYWP-AVDHSATY
| .|.||.||..||.||| |   |    ||||||||| ||......||.||||..|..||||| |.. ...|||.... |..|.||. ||| . . | ||
nkkknRykdilpydktrvkl..kgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeeslty

GPLMVYGR-REEVLSPNVTRRLFEIHHQDED-RVQEVVHLQMTTWPDHGSPRNPEAFLELHRRFREAQrnarNSRSGPVglpIVHCSAGVGRSGTFICLD
| . |  . .|.  . ..| | .|.....|. . .|| .|..|.||||| |..|...|.| |.... .    ...||||   .|||||||||.|||..||
gdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkveksk....eaksgpv...vVhCsaGvgRtgtfvald

TVFETLLAGRDpVEPLAIISRLRNCRNFMVQAVDQLDFIFRAI
...| | |... |. | |...||..|. ||| ..|. |. .||
illeqleaeee.vdvlqivkelRkqRpgmvqsleqYiflykai
0039614 (Phosphotyrosine protein) phosphatases II 8-252 1e-72 240.4 In-house 50-284 (297) alignment 
Range on Protein: 8-252
Range on HMM: 50-284/297.0
ASRAAVNARKQRYRDIVAYDHTRVSLAAAGGH-LGSDYINANYVVGYEK-ERAYIASQGPLPDTVGDFWRMAWEQTSRTIVMVAQVRENNRvKCELYWPA
 ..  .|  | ||.||..|||.|| |   .|. |.||||||.|| ||..  |..||.|||||.||.||||| ||| ...|||. .  |..| ||. ||| 
iallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfIatqgPlpetvedFwrmvweqgvtvivmLtklvelgr.kcaqywpe

VDHsaTYGPLMVYGRREEVlSPNVTRRLFEIHHqdEDRVQEVVHLQMTTWPDHGSPRNPEAFLELHRRFREAQRNArnSRSgpvGLPIVHCSAGVGRSGT
     |||.. |. ...|.  ...|.| .|. .  .. . .| |.| | ||||| | ..| .||. .  |||....  ...   |  .|||||||||.||
egg..tygdftvtllkveh.ldgytvrtlevtn..ngesrtvthfqytgwpdhgvppslellleflelvrealael..pkg...gpvlVHCsaGvgRtGt

FICLDTVFETLLAGrDPVEPLAIISRLRNCRNFMVQAVDQLDFIFRA
||......| |  .   | .| ....||..|. .||  .|. |...|
fiaaylmleqleke.ggvdvleavkelreqRpgavqtpsqyrflyda
subfamily_PTPN9_pd Subfamily PTPN9 6-253 2.3e-72 238.5 In-house 34-286 (297) alignment 
Range on Protein: 6-253
Range on HMM: 34-286/297.0
ANASRAAVNARKQRYRDIVAYDHTRVSLAAAGGHLGSDYINANYVVGYEKERAYIASQGPLPDTVGDFWRMAWEQTSRTIVMVAQVRENNRVKCELYWP-
..||.  .| .| || |.. ||.||| ||   ..  |||||||.| ||....|.|| ||||. || ||||| |||  ..|||...| |. |.||  ||| 
flasklranleknrytdvlcydetrvvlakvdedeasdyinanfvdGykqkkafiatqGplkktvsdfWrmvWeqevlvivmttrvvergrlkcgqyWpl

AVDHSATYGPLMVYGRREEVlSPNVTRRLFEIHHQDEDRVQEVVHLQMTTWPDHGSPRNPEAFLELHRRFREAQRNAR-----NSRSGPVGLPI-VHCSA
  ..|| .| | |     |. . . . | .||.. .... ..|.| |...|||.| |.. ...|.. .  ||.|  |      ...  | | || |||||
eeessaefgdlsvsnvevee.eedykvrvleiknvkteesrkvthfqflsWPdyGvPssaaslldvlekvrekqalavkelgdewkghpsgPPivvhcsa

GVGRSGTFICLDTVFETLlAGRDPVEPLAIISRLRNCRNFMVQAVDQLDFIFRAI
|.||.|||| ||   . |    . |.    ...||. | |..|  .|  | . |.
GiGrtGtfitldiclsrl.eevgtvdvvetvkllrtqrafsiqtpeqyefcylav
DSPc_SM00195 8-253 5.6e-72 237.6 In-house 20-258 (263) alignment 
Range on Protein: 8-253
Range on HMM: 20-258/263.0
ASRAAVNARKQRYRDIVAYDHTRVSLAAAGGHLGSDYINANYVVGYEKERAYIASQGPLPDTVGDFWRMAWEQTSRTIVMVAQVRENNRVKCELYWPAV-
 ..   | .|.||..|. |||||| |    .. |||||||||. |..|...||| |||||.|| ||||| ||. ...|||. .  ||.. ||. |||   
eaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlteeeengkekcdrywpees

DHSATYGPLMVYGRREEVLSPNVTRRLFEIHHQDEDRVQEVVHLQMTTWPDHGSPRNPEAFLELHRRFREAQRNArnsrsgpVGLPIVHCSAGVGRSGTF
... |.| . |  ...|  . ....| .|. .....  ..| ..|...||||| | ... .||| | ... ...         |  .|||||||||.|||
ggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkksksts.......sgpivVhCsaGvgRtgtf

ICLDTVFETLLAGRDpVEPLAIISRLRNCRNFMVQAVDQLDFIFRAI
...|.. . | .. . |.  .|...||. |  |||  .|. || .||
vtidiilskleeekk.vdifeivkelRkqRpgmvqtleqYlfiyeai
PTPc_SM00194 8-253 5.6e-72 237.6 In-house 20-258 (263) alignment 
Range on Protein: 8-253
Range on HMM: 20-258/263.0
ASRAAVNARKQRYRDIVAYDHTRVSLAAAGGHLGSDYINANYVVGYEKERAYIASQGPLPDTVGDFWRMAWEQTSRTIVMVAQVRENNRVKCELYWPAV-
 ..   | .|.||..|. |||||| |    .. |||||||||. |..|...||| |||||.|| ||||| ||. ...|||. .  ||.. ||. |||   
eaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlteeeengkekcdrywpees

DHSATYGPLMVYGRREEVLSPNVTRRLFEIHHQDEDRVQEVVHLQMTTWPDHGSPRNPEAFLELHRRFREAQRNArnsrsgpVGLPIVHCSAGVGRSGTF
... |.| . |  ...|  . ....| .|. .....  ..| ..|...||||| | ... .||| | ... ...         |  .|||||||||.|||
ggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkksksts.......sgpivVhCsaGvgRtgtf

ICLDTVFETLLAGRDpVEPLAIISRLRNCRNFMVQAVDQLDFIFRAI
...|.. . | .. . |.  .|...||. |  |||  .|. || .||
vtidiilskleeekk.vdifeivkelRkqRpgmvqtleqYlfiyeai
0042113 (Phosphotyrosine protein) phosphatases II 9-252 4.5e-71 234.4 In-house 4-238 (245) alignment 
Range on Protein: 9-252
Range on HMM: 4-238/245.0
SRAAVNARKQRYRDIVAYDHTRVSLAAAGGHLGSDYINANYVVGYEKERAYIASQGPLPDTVGDFWRMAWEQTSRTIVMVAQVRENNRVKCELYWPAvDH
..  .|  | ||.||..|||||| |   ||.|.||||||.|| ||.  . .||.|||||.||.||||| ||. ..||||. .  |..||||. |||  ..
allpenkdknrysdilpydhtrvklspdggdldsdyinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywpl.ge

SATYGPLMVYGRREEVlSPNVTRRLFEIHHQDEDRVQEVVHLQMTTWPDHGSPRNPEAFLELHRRFREAQRNarnsrsGPVGLPIVHCSAGVGRSGTFIC
| ||| ..|. ..||.  ...|.| .|...  .| ..||.|.. . ||||| | ..| .|..... |.|...      .. |  .|||||||||.||||.
sltygdftvtllseeh.lddytvrtlevtnlgddesrevihyhylpwpdhgvpdllellldflefvrkalae......dsngpvlVHCsaGvgRtGtfia

LDTVFETLLAGrDPVEPLAIISRLRNCRNFMVQAVDQLDFIFRA
.....| | .    | .  .. .||..|  .||  .|. |. .|
aylmleqleke.lgvsleeavkelrsqRpgavqtpsqyrflyea
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 2-252 1.4e-70 232.6 In-house 35-274 (288) alignment 
Range on Protein: 2-252
Range on HMM: 35-274/288.0
RQHSANASRAAVNARKQRYRDIVAYDHTRVSLAAAGGHLGSDYINANYVVGYEKERAYIASQGPLPDTVGDFWRMAWEQTSRTIVMVAQVRENNRVKCEL
...| .|.| ||||.| |||.|..||..|| |       |.|||||.|. |..|...|||.||||.|||.|||.. .|. . ||||.... |... ||| 
ktksvtagrlavnakknRyrnilpyDekrvklkkleeeagaDYinasyidgekkkkkyiatqgPladtvndfWelvyenktstivmltelveggktkCee

YWPAVDHSATYGPLMVYGRREEVLSPNVTRRLfEIHhqDEDRVQEVVHLQMTTWPDHGSPRNPEAFLELHRRFREAQRNArnsrSGPVglpIVHCSAGVG
|||. |.   || . |  . .. |   |.|.| ...   .    |. ..| ..||||| |.. . .||| |    |. .     .||.   |||||||||
YWPdadkpknyGsvtvtlveskeledfvlrkl.lle..kkkteleitqyqylaWpdhgvPeskapllellrqvkvanqad....tgpi...ivhCsaGvG

RSGTFICLDTVFETLLAgRDPVEPLAIISRLRNCRNFMVQAVDQLDFIFRA
|.|||| ||.. ... .  | .. ......||. |...|| . |  ||...
rtgtFialdalidavee.edyiDvagtvaklRkqRallvqtlkqYefiyev
subfamily_PTPRG_pd Subfamily PTPRG 4-253 2.4e-70 232.4 In-house 37-283 (563) alignment 
Range on Protein: 4-253
Range on HMM: 37-283/563.0
HSANASRAAVNARKQRYRDIVAYDHTRVSLAAAGGHLGS-DYINANYVVGYEKERAYIASQGPLPDTVGDFWRMAWEQTSRTIVMVAQVRENNRVKCELY
  |..|..  | || || .|||||..||.|.   |. .. |||||||. ||.|..|.||.||||.||. ||||| ||| . .|||.... |..| ||. |
ldaehsqkpenkrKnRylnivaydrsRvklsplpgkkkklDYinAnyidGyqkskafiatqgplkdtfddFWrmiWeqnvaiivmitnlvergrrkcdvY

WPAvDHSATYGPLMVYGRREEVLSPNvTRRLFEIHH------QDEDRVQEVVHLQMTTWPDHGSPRNPEAFLELHRRFreaqRNARNSRSGPVglpIVHC
||. |.| ||| | |   .||||.   | | . |..      .. | ...| . ..|.|||||.|  .   |   ..       |...  ||.   .|||
WPk.desetygalqvtlieeevlaly.tvrtlviknlklkkkkqcdteklvrqyhytkWPdhgvPehslpvLifvkks....saankaeaGPi...vvHc

SAGVGRSGTFICLDTVFETLlAGRDPVEPLAIISRLRNCRNFMVQAVDQLDFIFRAI
||||||.||.| |||. . .   .. |. . .. ..|  |||.||  .|  |.. |.
saGvgrtGtyivldtllkqi.qqenavnvfgflkhiraqRnflvqteEqYiflhdal
0040439 (Phosphotyrosine protein) phosphatases II 8-252 3.5e-70 231.7 In-house 5-241 (249) alignment 
Range on Protein: 8-252
Range on HMM: 5-241/249.0
ASRAAVNARKQRYRDIVAYDHTRVSLAAAGGHLGSDYINANYVVGYEKERAYIASQGPLPDTVGDFWRMAWEQTSRTIVMVAQVRENNRVKCELYWPAvD
 ..  .|  | ||.||..|||.|| |   .|. .||||||.|. ||   |..|| |||||.||.||||| ||. ...|||. .  |..|.||. |||  .
vallpenkdknrypdilpydhsrvklsilpglflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywpl.g

HSATYGPLMVYGRREEVlSPNVTRRLFEIHHQDEDRVQEVVHLQMTTWPDHGSPRNPEAFLELHRRFREAQRNArnsrsGPVGLPIVHCSAGVGRSGTFI
.| .|| ..|  ...|| ....|.| .|...  .. . .| |.|.| ||||| | ..| .|.. .. |.|....     .. |  .|||||||||.||||
gsleygdftvtllsvev.kddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleel.....pkggpvlVHCsaGvgRtGtfi

CLDTVFETLLAGRDpVEPLAIISRLRNCRNFMVQAVDQLDFIFRA
......| |   .. | .. ... ||..|. .||  .|. |. .|
aaylmleqlekelg.vdleeavkllrsqRpgavqnpeqyrflyea
0045098 (Phosphotyrosine protein) phosphatases II 14-252 2.4e-69 229.1 In-house 33-267 (278) alignment 
Range on Protein: 14-252
Range on HMM: 33-267/278.0
NARKQRYRDIVAYDHTRVSlaaagghlgsDYINANYVVGYekERAYIASQGPLPDTVGDFWRMAWEQTSRTIVMVAQVRENNRVKCELYWPAvDHSATYG
|. | ||.||..|||.||           |||||.|. ||   ...|| |||||.|| ||||| ||. ...|||.... |..|.||. |||  ..| |||
nldknRykdilpydhsrVk..........dYINAsyidgy..pkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrekcaqywpe.ggsltyg

PLMVYGRREEVLsPNVTRRLFEIHHQ----DEDRVQEVVHLQMTTWPDHGSPRNP--EAFLELHRRFREAQRNARNS---------RSgpvGLPIVHCSA
.. |.   |||| ...| | .....      ..   .| ||....|||||.| .|    |||| .. |||.... .          ..   |  .|||||
dftvtllseevl.ddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsg...gpvlVHCsa

GVGRSGTFICLDTVFETLlagRDPVEPLAIISRLRNCRNF-MVQAVDQLDFIFRA
||||.||....... | |    . | .| ... ||..|.. .||  .|. |....
GvgRtGtlvaaylmlell...eggvdlleavkelrsqRpglavqnleqyrflyef
subfamily_PTPN3_pd Subfamily PTPN3 6-253 1.3e-68 225.9 In-house 33-271 (280) alignment 
Range on Protein: 6-253
Range on HMM: 33-271/280.0
ANASRAAVNARKQRYRDIVAYDHTRVSLAAAGghLgsDYINANYVV----GYEKERAYIASQGPLPDTVGDFWRMAWEQTSRTIVMVAQVRENNRVKCEL
 .|.| . |. | |||||..||.|||.| ..      ||||||||     . .    |||.||||..|. |||.| |||.|..|||.... |. ||||  
isaarkpenlsknryrdilpydatrvklkese..t..dyinanyvnmeipstglvnryiatqGPlaktatdfWqmvweqksslivmlttlverGrvkChq

YWPAVDHSATYGPLMVYGRREEVLSPNVTrRLFEIHHQDEDRVQEVVHLQMTTWPDHGSPRNPEAFLELHRRFREAQrnarNSRSGPVglpIVHCSAGVG
|||  ... .|| ..|. ..|.  .  |. | . ........ .....|| . ||||| | ... |||. .| |...    .... ||   .||||||.|
yWPetedeleygefsvkcekedetksyvl.relvlkdketkeerkilqlqylaWpdhgvPddsadflefvervrklr....sgkeePv...vvhCsaGig

RSGTFICLDTVFEtLLAGRDPVEPLAIISRLRNCRNFMVQAVDQLDFIFRAI
|.| .| |.| .  |.  ..|| ||.|....|. |  .||...|  |.  ||
rtGvlilletala.lieaaepvypldivrtmrdqramlvqtasqykfvCeai
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 6-253 2.3e-68 225.6 In-house 40-279 (319) alignment 
Range on Protein: 6-253
Range on HMM: 40-279/319.0
ANASRAAVNARKQRYRDIVAYDHTRVSLAAAGGHLGSDYINANYVVGYEKERAYIASQGPLPDTVGDFWRMAWEQTSRTIVMVAQVRENNRVKCELYWPA
 . .    | .| ||..|.|||.||| |..  |  |||||||... ||......|| |.|| .|. ||||| ||. | ..||.... |. .||.. ||| 
fdsaskeenkkknryqnilaydrtrvvlseldgvegsdyinasfidgyqerekfiatqaPlentiedfWrmvWeeessivvmltklveklkvklkkywpe

VDHsATYGPLMVYGRREEVLSPNVTRRLfEIHHQDEDR-VQEVVHLQMTTWPDHGSPRNPEAFLELHRRFREAQRNarnSRSGPVglpIVHCSAGVGRSG
 ..  .|| |.|    || |.  . |.| ..... ..    ||.| | | ||||. |..  . |.| .| |.....   . |||.   .||||||||| |
enf.eeyGrlivtleeeeeledyiirkl.klnkkssevetRevkhfqyteWpdhdvPekatslldllkrirksrek...tqsgPi...vvhCsaGvGRtG

TFICLDTVFETLLAgRDPVEPLAIISRLRNCRNFMVQAVDQLDFIFRAI
||| || ..| .      ..   ..||||  ||.|||  .|  ||. |.
tfivldamlervke.egvlDvfstvsrlRtqRnimvqrpeqYkfiyeal
subfamily_PTPN12_pd Subfamily PTPN12 4-253 9.8e-68 223.1 In-house 30-273 (290) alignment 
Range on Protein: 4-253
Range on HMM: 30-273/290.0
HSANASRAAVNARKQRYRDIVAYDHTRVSLAAAGGHLGSDYINANYVVGYEKERAYIASQGPLPDTVGDFWRMAWEQTSRTIVMVAQVRENNRVKCELYW
.|..|... .| .| ||.||. ||..|| |    .. ||||||||.. | |.. .|||.|||||.|. ||||| ||.. . .||. .. |... ||| ||
ysteagekeenvkknrykDilPydksrvelskieeeegsdYinanfikgvegkleyiaaqgPLpktlddfWrmiweknveivvmaCrevelgkkkCerYW

PAV-DHSATYGPLMVYGRREEVLSPNVTRRLFEIHHQDEDRvqEVVHLQMTTWPDHGSPRNPEAFLELHRRFREAQRnarnSRSGPVglpIVHCSAGVGR
|   ... ..|.. |   .|. .. . . | .....|.| |  .|  .. | ||||| |....  ||| . .|| |.    | . |.   .|||||||||
peegeeelefgefevtleeekavdddflirtLkveaqkesr..kvyqfhYtaWPDhgvPssaksllelielvrelqe....sedaPl...vvhCsaGvGr

SGTFICLDTVFETLLAGRD--PVEPLAIISRLRNCRNFMVQAVDQLDFIFRAI
 || | .| | | | |..    ..   .. .||. |. .||. .|  ....|.
tGtiiaidyvrellkaekipeeldvfdlvlelrkqraalvqtkeqyelvykav
subfamily_Ptp69D_pd Subfamily Ptp69D 3-253 4.6e-67 221.3 In-house 37-282 (307) alignment 
Range on Protein: 3-253
Range on HMM: 37-282/307.0
QHSANASRAAVNARKQRYRDIVAYDHTRVSLAAAGGHLGSDYINANYVVGYEKERAYIASQGPLPDTVGDFWRMAWEQTSRTIVMVAQVRENNRVKCELY
..|...|    || | || ||.|.|.||| |.   |.  ||||||... ||.... .||.|.|.  |.|||||| .|| . .|||.... | || ||. |
dkstkvsekkenalknRyedikafDktRvkLkkingkedsdYinasfikgykekkkfiaaqdPveatigDfWRmiaeqevtlivmlsnlteknrkkcakY

WPAvDHSATYGPLMVYGRREEVLsPNVTRRLFEIHHQD-----EDRVQEVVHLQMTTWPDHGSPRNPEAFLELHRRFREAQRNArnsrSGPVglpIVHCS
||  ..   || ..|   .||   .. ..| ... ...     ..  ..||  . |.|.|   |. ... |.| .. || ...      .|.   .||||
Wpi.edevqygdilvklvseekh.sdyiiReldvskkkeesgevedsrkvvqyhytgWkDskvPevargllklieqvrelykln....rsPi...vvhCs

AGVGRSGTFICLDTVFETLLAgRDPVEPLAIISRLRNCRNFMVQAVDQLDFIFRAI
|||||||.|..|| ... | |  | |.  ...  ||. ||..||  .|  |..||.
aGvgrsgifvaldsllqqlka.edkvdifetvkdLrsqRnllvqsleqYvflyral
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 5-253 5.4e-67 221.1 In-house 47-286 (298) alignment 
Range on Protein: 5-253
Range on HMM: 47-286/298.0
SANASRAAVNARKQRYRDIVAYDHTRVSLAAAGGHLGSDYINANYVVGYEKERAYIASQGPLPDTVGDFWRMAWEQTSRTIVMVAQVRENNRVKCELYWP
. ...|.  | .| || ||.|.|..|| | .  .   |||||| .. .|... |.||.|.||. || ||||| .|. . ||||. ...| ...|.. |||
ekevarkpenkkkNRyadiialdssRvvLekedadeesdYiNAsflhaykgrnafiatqaPltetvedFWrmvteedigtiVmltnleeldktkyhkywP

AVdHSATYGPLMVYGRREEVLSpNVTRRLFEIHHQDEDRVQEVVHLQMTTWPDHGSPRNPEAFLELHRRFREAQRNARNsrsGPVglpIVHCSAGVGRSG
 . ...||| . |  ...|. . ... | .......|.. .||..|..|.|||.| |.| .. |.| |. |  |..| |    ||   ||.|||||||||
de.gketygeitvsllskeefa.dlivrklkvskkkeekerevrqlhftsWpdkgvpenatsvldllrkvrasqqqagn...kpv...ivqCsaGvgRsG

TFICLDTVFETLLAGRdPVEPLAIISRLRNCRNFMVQAVDQLDFIFRAI
||| .|.|.| . . .  |. . .. .||. |  .||. .|  ||. |.
tfiaidsvlervkkeq.vvDvfqvvkvlRkkrpgavqteeqYvfiyeav
subfamily_PTPN6_pd Subfamily PTPN6 5-253 7e-66 217.3 In-house 45-293 (306) alignment 
Range on Protein: 5-253
Range on HMM: 45-293/306.0
SANASRAAVNARKQRYRDIVAYDHTRVSLAaAGGHLGSDYINANYVVG--YEKERAYIASQGPLPDTVGDFWRMAWEQTSRTIVMVAQVRENNRVKCELY
| . .. . |..|.||. |. .|||||.|.   .  |||||||||. .   .....|||.|| |..|| |||||.|.. || |||. .  | .. ||  |
srkegakpenkeknryknilPfDhtrvilk.epsvpgsdyinanyikkevkgsdksyiatqgclettvsdFWrmvwqensrvivmttkevErgkekCarY

WPAVDHSATYGPLMVYGRREEVLSPNVTRRLFEIHHQDEDRVQEVVHLQMTTWPDHGSPRNPEAFLELHRRFREAQRNARNSRSGPVglpIVHCSAGVGR
||.. .. .|| . |   .|. |.  . |.|   ....... .||.... ..||||| |..|.|.|.. .  .. |.. .....||.   .||||||.||
WPdeeekeeyGkisvtnvseksladYilRelsvskkkkkkeerevfqyhfksWPdhgvpkdpgavLdfledvnrkqeeleeaeagpi...vvhCsaGiGR

SGTFICLDTVFETLLA-GRD-PVEPLAIISRLRNCRNFMVQAVDQLDFIFRAI
 |||| .|.. ...   | | ...   ..  .|. |. .||  .|  |...||
tGtfiviDillkliekkgldadidiqklvksvreqrsglvqteqqykfvykai
0037934 (Phosphotyrosine protein) phosphatases II 8-252 1.4e-65 216.5 In-house 4-237 (243) alignment 
Range on Protein: 8-252
Range on HMM: 4-237/243.0
ASRAAVNARKQRYRDIVAYDHTRVSLaaaGGhlgSDYINANYVVGYEKeraYIASQGPLPDTVGD----FWRMAWEQTSRTIVMVAQVRENNRVKCELYW
 ..  .|  | ||.||..|||.|| |   .|   |||||||.. ....   .||.|||||.|| |    |||| ||. ...|||. .  |..|.||. ||
iallpenlsknrysdilpydhsrvkl...eg...sdyinanliyvtpr...liatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqyw

PavdHSATYGPLMVYGRREEVLsPNVTRRLFEIHHQD-EDRVQEVVHLQMTTWPDHGSPRNPEAFLELHRRFREAQRN-----ARNSRsgpvGLPIVHCS
|    . |||...|    ||.| ...| | ... . | .| ...|.|.. . ||||| | .|| .|....  || ...     |..|     |  .||||
p...gevtygdftvtllseehl.ddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsg....gpvlVHCs

AGVGRSGTFICLDTVFETLlagrdPVEPLAIISRLRNCRNF-MVQAVDQLDFIFRA
|||||.||.|..... . |      | .. .. .||..|.. .||  .|. |. .|
aGvgRtGtliaaylmllll.....gvdleeavkllreqRpgkavqtpsqyrflyea
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 1-252 3.4e-65 215.1 In-house 36-274 (315) alignment 
Range on Protein: 1-252
Range on HMM: 36-274/315.0
GRQHSANASRAAVNARKQRYRDIVAYDHTRVSLAAAGGHLGSDYINANYVVGYEKERAYIASQGPLPDTVGDFWRMAWEQTSRTIVMVAQVRENNRVKCE
|. |  . ..   | .| || .|.|||..|| |     . .|||.|||.. ||.|.| |||.|||.. .|.||||. .|.   .|||.... |... |.|
gqlhpldvakkienkqknryiniiaydksrvqlpllendphsdyvnanfidGynkkrryiaaqgpnvasvkdfwrlvfeedigkivmltnlvegekrkae

LYWPavDHSATYGPLMVYGRREEVLSpNVTRRLFEIHHqdEDRVQEVVHLQMTTWPDHGSPRNPEAFLELHRRFREAQRNARnsrsGPVglpIVHCSAGV
 |||  |.  .||.. |  . ||| . ..| | . .    .|...||| |..|.||| | |.   ....|.|. .  . |.     |..   .|||||||
kywp..dkkviyGkitvtrkseevnt.eytvrtlsvvf..gdnirevvqlhytswpdmgvpkytiplmnlirtvkqhhtnsv....gai...vvhcsaGv

GRSGTFICLDTVFETLLAgRDPVEPLAIISRLRNCRNFMVQAVDQLDFIFRA
||.||||.||.|.. . |  . ..   .| ..|. |  |||...| .||. |
GrtGtfitldavldqaea.enaidvynfitgvrqnrikmvqvaeqyqfiyda
subfamily_PTPRA_pd Subfamily PTPRA 7-253 2.6e-63 208.9 In-house 51-291 (330) alignment 
Range on Protein: 7-253
Range on HMM: 51-291/330.0
NASRAAVNARKQRYRDIVAYDHTRVSLAAAGGHLGSDYINANYVVGYEKERAYIASQGPLPDTVGDFWRMAWEQTSRTIVMVAQVRENNRVKCELYWPAv
...    | .|.|. .|. ||..|| |.   |.  |||||| .. ||..   .||.|||. .|| ||||| ||| | ||||.....| .. ||. |||  
elaskeenkeknrvvnilPydfsrvilsvkeGveesdyinasfidGykekdkfiaaqGPkeetvedfwrmiweqksativmltelkerkeekcaqywPd.

DHSATYGPLMVYGRREEVLSpNVTRRLFEIH----HQDEDRVQEVVHLQMTTWPDHGSPRNPEAFLELHRRFREAQRNarnsRSGPVglpIVHCSAGVGR
. . ||| . |  . |.||  ..| | | ..    ...|.... |  . .|.||| | | .|   |.| .. .. ...     .||.   .|||||||||
eGlvtyGnirvevedetvlv.dytvrkflvqqlpdatrekksrlvrqfhftswPdvGvPfepiGmlkllkkvkklnqq....sagpi...vvhcsaGvGr

SGTFICLDTVFETLLAGRdPVEPLAIISRLRNCRNFMVQAVDQLDFIFRAI
.|||| ||.|.| . | |  |.   ...|||. |  |||.  |  ||....
tGtfivldavlervkaer.kvdvfefvkrlrlqrpqmvqtdeqyefiykvl
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 7-253 3e-62 205.5 In-house 39-279 (305) alignment 
Range on Protein: 7-253
Range on HMM: 39-279/305.0
NASRAAVNARKQRYRDIVAYDHTRVSLAAAGGHLGSDYINANYVVGYEKERAYIASQGPLPDTVGDFWRMAWEQTSRTIVMVAQVRENNRVKCELYWPAV
.  .  .|..|.|...|. .|. |. |..   .  ||||||.|| ||... .||..||||..|| ||||. .|   .||||.....|... ||. |||  
dvgkkeankaknrlkeitlldddriiltekeslddsdyinasyvdgykrkkkyivaqgPlkntvadfWrliveekvstivmltklveggkdkCrqYWpes

-DHSATYGPLMVYGRREEVLSPNVTRRLfEIHHQDED-RVQEVVHLQMTTWPDHGSPRNPEAFLELHRRFREAQRNarnSRSGPVglpIVHCSAGVGRSG
  ..  .|...|  . |.  |  ..|.| .|  .|||   . |...|.|.||||| |. . ..|.| .| ...|..   ..  |.   .|||||||||.|
ktekkefgefsvelksektasdyieRkl.kisiededkesrtvlqyqltdWPdhGvpqfatsllslikrvqkdqkk...dkgvpl...lVhCsagvgRtG

TFICLDTVFETLLAgRDPVEPLAIISRLRNCRNFMVQAVDQLDFIFRAI
.||..|  .| | .  . |.   .. .||. |  |||  || .|.. |.
vfiavdialerlkk.EevvdvfevlkqlRskrmkmvqtldqYvflhdal
subfamily_PTPRK_pd Subfamily PTPRK 9-253 7.6e-62 203.9 In-house 38-273 (314) alignment 
Range on Protein: 9-253
Range on HMM: 38-273/314.0
SRAAVNARKQRYRDIVAYDHTRVSLAAAGGHLGSDYINANYVVGYEKERAYIASQGPLPDTVGDFWRMAWEQTSRTIVMVAQVRENNRVKCELYWPavDH
..   | .|.|. ||.|||..|| | .  |   ||||||... .|.. .|.|. ||||..|| ||||. ... . .|||.... |. ||||  |||  ..
akkdenreknrsgdilaydrsrvflitidgdpssdyinaalidsykrpaafivtqgPlqetvkdfWrlvydencasivmltelvevgrvkClkyWP..ed

SATYGPLMVYGRREEVLSPNVtRRLFEIHH--QDEDRVQEVVHLQMTTWPDHGSPRNPEAFLELHRRFREAQRNarnsRSGPVglpIVHCSAGVGRSGTF
. .||.. |   . |.|.  |  |.| ...  .  . ..|| ..| ..||||. | . ...|.| ||  . | .    . |..   .|||||| ||.|||
tevygdikvelvetellaelv.vrifrveklargqeeirevrqfqflgWpdhdvPvsatgllklvrrvkksqee....eaGri...vvhCsaGaGrtGtf

ICLDTVFEtLLAGRDPVEPLAIISRLRNCRNFMVQAVDQLDFIFRAI
| .|.| . ..  .. |.   ..  ||. .  ||.. .|  ||. .|
iaidivld.mieregvvdvfnavktlrsrkvnmveteeqykfiydvi
subfamily_PTPN13_pd Subfamily PTPN13 6-253 1.2e-61 203.5 In-house 29-265 (273) alignment 
Range on Protein: 6-253
Range on HMM: 29-265/273.0
ANASRAAVNARKQRYRDIVAYDHTRVSLAAAGGhlgsdYINANYV---VgYEKERAYIASQGPLPDTVGDFWRMAWEQTSRTIVMVAQVRENNRVKCELY
.. .. . | .| |||... ||.||| | . ||     ||||...   |  ..|  |||.|||||.|| |||.| |||... |.||.. .|...|||. |
cevgkkkenkdknryrnvlPydetrvklgdegg.....yinaslikvpv.gkdeyeyiacqGPlPetvkdfwqmvweqkaeviamvtlekekgkvkchry

WPAVDHSAT--YGPLMVYGRREEVLSpNVTRRLFEIHHQDEDRVQEVVHLQMTTWPDHGSPRNPEAFLELHRRFREAQRnarnsRSGPVglpIVHCSAGV
||   .. .  .. | |   . . |. . . | .......  ...||.||....||||| |.... .|.. .. |. |.      .||.   .||||||.
wPesknkklkvsnrlevellkvqkld.gfvvralavkdsesgesrevahlnfvkwPdhgvPssaaellqfvaevrrlqt.....dagPi...vvhcsaGi

GRSGTFICLDTVFEtLLAGRDPVEPLAIISRLRNCRNFMVQAVDQLDFIFRAI
|||||.|..|.|.. |..   ...   |. .||. |. .||. ||  |...||
GrsGtlitidvvlg.lierdkefdvkeivrklreqrqgvvqtkdqyifvykai
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 9-253 1.6e-61 202.7 In-house 4-238 (250) alignment 
Range on Protein: 9-253
Range on HMM: 4-238/250.0
SRAAVNARKQRYRDIVAYDHTRVSLAAAGGHLGSDYINANYVVGYEKERAYIASQGPLPDTVGDFWRMAWEQTSRTIVMVAQVRENNRVkCELYWPaVDH
..   |  | || ||.|.|..|| |    |   |||||| .. ||....|.||.||||..|. ||||| .|. | ||||.....|.... .. ||| |..
akkpqnkeknryadiialdssrvvLekekgdkesdyinasflhgyderkafiatqgPlqatiedfWrmvleeksgtivmLtnLkesekt.yhqywP.vek

SATYGPLMVYGRREEVLSpNVTRRLFEIHHQDEDRVQEVVHLQMTTWPDHGSPRNPEAFLELHRRFReaqRNARNSRSGPVglpIVHCSAGVGRSGTFIC
. .|| ..|    .|. . ..| | . . .. .   . |..|. ..||| | |.. .| ||| .. .   .. ... ..||   ||.|||||||||.|| 
aekyGdvtvsllskeefa.dytkrklklskakkaderivrqlhfvvWPdkgvPevatavLellkkvq...asqqqagnaPv...ivqCsaGvgrsGafia

LDTVFETLLAGRdPVEPLAIISRLRNCRNFMVQAVDQLDFIFRAI
.|.|.| |   .  |.   .| .||. |  .|.. .|  |....|
idavlerlkkek.vvdvfkvikvlrkdrphavesleqyvfvyeii
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 7-253 6e-61 200.9 In-house 21-264 (274) alignment 
Range on Protein: 7-253
Range on HMM: 21-264/274.0
NASRAAVNARKQRYRDIVAYDHTRVSLAAAGGHLG-SDYINANYVVGYE-KERAYIASQGPLPDTVGDFWRMAWEQTSRTIVMVAQVRENNRVKCELYWP
.  . . ...|.||..|.  ...||.| .. ..   |.||||||. ||. ...||.| ||||| || ||||| ...... |||.....|.|. ||. |.|
eeldvfgsqtknryktilPnensrvllesessededssyinanyikGydeeskayvatqGPlpntvadfWrmiyqeevqvivmltklkeaneqkCavyfP

AVDH---SATYGPLMVYgRREEVLSPNVTRRLFEIHHQDEdrVQEVVHLQMTTWPDHGSPRNPEAFLELHRRFREAqRNARNSRSGPVglpIVHCSAGVG
   .   | .|| . .   .. |   . . | . .... .   ..|.|   | |||| ||......|.| .  .|. |...| . .||   .||||||.|
daedyeiserygdveik.vekiverndysvrklvlkyler..ersvkhywytdWPdhksPddantlldlvlevees.reeenaklapv...vvhCsaGiG

RSGTFICLDTVFETLlAGRDPVEPLAIISRLRNCRNFMVQAVDQLDFIFRAI
| | ||  .     |   .  |. | |.. ||  |  |||. .| ..|.||.
rtGcfiaisiavrql.reeivvdvlkivcnlrldrGGmvqtseqyelihral
subfamily_PTPN23_pd Subfamily PTPN23 9-253 2.4e-60 198.8 In-house 38-276 (288) alignment 
Range on Protein: 9-253
Range on HMM: 38-276/288.0
SRAAVNARKQRYRDIVAYDHTRVSLAaaggHLGSDYINANYVVGYEKE-RAYIASQGPLPDTVGDFWRMAWEQTSRTIVMVAQVRENNRVKCELYWPA-V
. | ... | |.|||. |||.|| |         ||||| .| .       .||.|.||. |..|||.| .|| |..|||. .  | .. |.. |||.  
aiaklyseknrsrdilPyDhnRvklr....gskDDYinAsfvkdlspgcPdfiatqaPlqstlnDFWlmvyeqkssviVmllskeelgkpkvdrYwPedk

DHSATYGPLMVYGRREEVLSPNVTrRLFEIHHQDEDRVQEVVHLQMTTWPDHGSPRNPEAFLELHRRFREAQRNARNSRSGPVglpIVHCSAGVGRSGTF
... ..|.| |  .... ... |  | ......|.|.|..|.|||.|.||..| |  || .|..    ..| .. ..    |.   .|||||||||.|.|
getvkfgdlsvtlksvretethve.rvlkletldadavksvshlqltsWpelGvPasPetllqfldevesayeavqrksktPl...vvhCsaGvgRtgvf

ICLDTVFETLLAGRDPVEPLAIISRLRNCRNFMVQAVDQLDFIFRAI
 .. .. . | .|   .. . ..||||. | |||| ..|| | . |.
alvyaavrelekgnglldiiqvvsrlreqRrfmvqekeqlkfsyeav
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 3-253 7.1e-59 194.0 In-house 9-260 (270) alignment 
Range on Protein: 3-253
Range on HMM: 9-260/270.0
QHSANASRAAVNARKQRYRDIVAYDHTRVSLAAAGGHLGSDYINANYVVGYEK-ERAYIASQGPLPDTVGDFWRMAWEQTSRTIVMVAQVRENNRVKCEL
... .   || ...  ||.||.   .||| |.       . ||||||| |... ...|||..|||| |. .|||| ||. ...|||.... |..| ||| 
tsesdlpeaargkklnRyadiLPsPatRvrleeleedsataYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkgrkkCer

YWPAVDHS---ATYGPLMVYGRREEVlSPNVTRRLFEIHhqDEDRVQEVVHLQMTTWPDHGSPRNPEAFL---ELHRRFREAQRNARNSR-SGPVglpIV
||||  ..    ..| . |    ||  .    ..  ...  ..   ...|| ...|||||| ||...  |   .| . .|. .|  .. . ..|.   .|
YWpaepkekvkledgkikvlalseek.eegyiltrlrle..ekgeerrlvHfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkaePl...lv

HCSAGVGRSGTFICLDTVFETLlAGRDPVEPLAIISRLRNCRNFMVQAVDQLDFIFRAI
||||||||.||.| ||.....|   .  |..||||..||. |  .|| ..|  |...|.
HcsaGvgRtGtlialDiavrlL.eetkkvdvlaiieelRkdRmalvqhpeqyeflykav
subfamily_PTPN1_pd Subfamily PTPN1 4-253 8.8e-59 193.6 In-house 22-267 (290) alignment 
Range on Protein: 4-253
Range on HMM: 22-267/290.0
HSANASRAAVNARKQRYRDIVAYDHTRVSLAAAGGhlgsDYINANYVVGYEKERAYIASQGPLPDTVGDFWRMAWEQTSRTIVMVAQVRENNRVKCELYW
.......   |  . ||||.  |||.|. |  |      |||||. |   | .| || .|||||.||. ||.| ||| |...||. .| |....||  ||
fptreaklpenrnlnryrdvspydhsrikleradn....dyinaslveleeakrsyiltqGPlpntvdhfWqmvWeqkskavvmlnkvvekeqikcaqyw

PAVDH--SATYG--PLMVYGRREEVLSpNVTRRLFEIHHQDEDRVQEVVHLQMTTWPDHGSPRNPEAFLELHRRFREAQRNARNsrsgpVGLPIVHCSAG
|  ..  . ..    | |   .||. | . |.||.|.. .  .. .|..|   ||||| | |. | |||..  . ||.   ...     || ...|||||
Pqgeeekellledtklkvkliseerks.yytvrllelenlktqetreilhfhyttwpdfgvpespaaflkflfkvresGslssd.....vGpavihcsaG

VGRSGTFICLDTVFETLLAGRD--PVEPLAIISRLRNCRNFMVQAVDQLDFIFRAI
.||||||. .||..  . .  |   |.    .  ||. |  ..|. |||.| . ||
iGrsGtfclvdtclvliekkddlssvdikkvllelrkyrlGliqtadqlrfsylai
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 3-252 2.2e-56 185.9 In-house 35-278 (290) alignment 
Range on Protein: 3-252
Range on HMM: 35-278/290.0
QHSANASRAAVNARKQRYRDIVAYDHTRVSLAAAGGHL--GSDYINANYVVGYEKERAYIASQGPLPDTVGDFWRMAWEQTSRTIVMVAQVRENNRVKCE
.|...   .  | ...|...|| ||  |. |   .||     .|||| |. ||.....||| |||...|. |||.. |.. .  |||. .. |...||| 
ehtvtvgltssnkllnRfanivvyddnritLrpisghkDCtneyinAcyikgykekkqyiatqgpvsntlvdFWkliwqekvtiivmltniieegkvkCq

LYWPAVDHSAtYGPLMVYGRREEVLSpNVTRRLFEIHHQDE-DRVQEVVHLQMTTWPDHGSPRNPEAFLELhrrFREAQRNARNSRSGPVglpIVHCSAG
 |||. | .| ||.  .    ||.|. . ..| .|...... .. |.|...|.|.|...|.  ||.. | .   ..| ... | .  ...   .||||..
qYWpdsdtka.ygefsikllneetln.eyierklevknknsagakqsvtqyqitnwdstgkvtnpqtillv...ieemyktqrkrgntsi...vvHCSdt

VGRSGTFICLDTVFETLLAgRDPVEPLAIISRLRNCRNFMVQAVDQLDFIFRA
||||..|. ..|  .        .. .... ..| ..  .||.|.|. .||. 
vgrsavfcaaattinkckt.egvidvfqvlksqRiqkpgsvqtvqqyqgifqi
subfamily_PTPN14_pd Subfamily PTPN14 6-253 2e-55 182.9 In-house 41-292 (300) alignment 
Range on Protein: 6-253
Range on HMM: 41-292/300.0
ANASRAAVNARKQRYRDIVAYDHTRVSLAAAGGHlGSDYINANYV---VGyEKERAYIASQGPLPDTVGDFWRMAWEQTSRTIVMVAQVRENNRVKCELY
 ....  .||.|.|..|.. |...|| |...     ..||||  .   ||  ||| ||..||||. || |||.| |||  . |||... .|. . |.  |
lstaklpenaeknrfkdvlPyednrvelsptken.stgyinassikvsvg.gkersyivaqgPleltvqdfWqmvWeqgvqlivmlteeeedgkeksfky

WPAV---DHSATYGPLMVYGRREEVlSPNVTRRLFEIHHQDEDRVQEVVHLQMTTWPDHGSPRNPEAFLELHRRFREAQRNARNSRSG-PVG-LPIVHCS
.|      .....|   |. .  |  |. |. . ....|    . ..|.||| | ||||| |.... ||.  ....  .|.. .....  .    .||||
fPkleskkktvefgkfkvttkfsed.sdsvittglklkhlpskeertvwhlqytDWpdhgvPeDvkgflsyLeevqsvrrktnseveskeskPPvlvhCs

AGVGRSGTFICLDTVFETLLAGRDpVEPLAIISRLRNCRNFMVQAVDQLDFIFRAI
|||||.|  |  | . .||  ... ..   ...|||. | ..||.. |  |.....
aGvGrtGvlilsdlliatlehnee.idikkvlarLreqrmllvqtlaqYkfvYkvl
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 10-253 1.2e-54 180.1 In-house 34-273 (287) alignment 
Range on Protein: 10-253
Range on HMM: 34-273/287.0
RAAVNARKQRYRDIVAYDHTRVSLAAaGGHLGSDYINANYVVGYEKERAYIASQGPLPDTVGDFWRMAWEQTSRTIVMVAQVRENNRVKCELYWPAVDHS
    ...| || |.. .|.||| |.|  |.||||||||||| .|... |.||.|||.. ||.||||. .|. | .......  |. | ||  |||  .  
eelaavkknryadvlPiddtrvllsa.egelGsdyinanyvasytddeafiaaqgPiaatvrdfwravletrsasvitmtreveearlkcykywPerevP

ATYGPLMVYGRREEVLSPNVTRRLFEIHHQDEDRVQEVVHLQMTTWPDHGSPRNPEAFLELHRRF---REAQRNARNsrsgpVGLPIVHCSAGVGRSGTF
   |   |     ....|. . | . . . .    . |  |.. .|||.. .    ... .        |..|.| .     || ..||...|.||||..
mrvGGysvvlldydikePeygvralrlidletrearvvkqldllswPdkvlaPtavglirfvldvkqhielardase.....vGPlvvhddvGiGrsGil

ICLDTVFETLLAgRDPVEPLAIISRLRNCRNFMVQAVDQLDFIFRAI
. . .. . |.     |.. |.. |||. |. .|||| || ... |.
latlvlvsrled.lGrvdvaavvirlreyraalvqavvqlrllyeal
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 10-253 6.2e-53 175.2 In-house 57-287 (319) alignment 
Range on Protein: 10-253
Range on HMM: 57-287/319.0
RAAVNARKQRYRDIVAYDHTRVSLAAAGGHLGSDYINANYVVGYEKERAYIASQGPLPDTVGDFWRMAWEQTSRTIVMVAqvrennRVKCELYWPAvDHS
    |  | |. .|.|.|...| |    |  .|||||| .| || ..  |||.||||..|. ||||| ||. . |||...      . ||  |||  .  
nldqnkdknriinilafdknvvklerliGeefsdyinasfvtGyqrkdkyiaaqGPldntladfWrmiweyncstivllt......kdkcsqywpl.kiv

ATYGPLMVYGRREEVlSPNVTRRLFEIHH-QDEDRVQEVVHLQMTTWPDHGSPRNPEAFLELHRRFREAQRNARNsRSgPVglpIVHCSAGVGRSGTFIC
 ...   |     |  . . . | .|. .   |  ....    .  |||.| |  |  .. | .. |  ..  .. |  ..   .|||||||||.|..| 
ikeerfkvkvdsvee.taeyvvrdielsedgkekdirkitqfhflGwpdvGvpdypsdlmrlvkkvrhltskenh.ra.ni...vvhcsaGvGrtGvyiv

LDTVFETLlAGRDPVEPLAIISRLRNCRNFMVQAVDQLDFIFRAI
||.... .    . |.   ..  ||. || .|| . |  ||. |.
ldvlldrm.keekqvdvynfvrdlrqqrntlvqdlvqykfiysal
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 10-253 1.3e-52 174.1 In-house 21-251 (284) alignment 
Range on Protein: 10-253
Range on HMM: 21-251/284.0
RAAVNARKQRYRDIVAYDHTRVSLAAAGGHLGSDYINANYVVGYEKERAYIASQGPLPDTVGDFWRMAWEQTSRTIVMVAqvrennRVKCELYWPAvDHS
    |  | |. .|.|.|...| |    |  .|||||| .. || ..  |||.||||..|. ||||| ||. . |||...      . ||  |||  .  
nldqnkdknrighilafdknvvklerliGeefsdyinasfitGyqrkdkyiatqGPldntladfWrmiweyncstivllt......kdkcsqywpl.kiv

ATYGPLMVYGRREEVlSPNVTRRLFEIHH-QDEDRVQEVVHLQMTTWPDHGSPRNPEAFLELHRRFREAQRNARNsRSgPVglpIVHCSAGVGRSGTFIC
 ...   |     |  | . . | .|. .   |  ....    .  |||.| |  |  .. | .. |  ..  .. |. ..   .|||||||||.|..|.
ikeerfkvkvdsvee.seeyvvrdielsedgkekdirkirqfhflgwpdvgvpdypsdlmrlvkkvrhltskenh.ra.ni...vvhcsagvgrtgvyiv

LDTVFETLlAGRDPVEPLAIISRLRNCRNFMVQAVDQLDFIFRAI
||.... .    . |.   ..  ||. || .|| . |  ||. |.
ldvlldrm.keekqvdvynfvrdlrqqrntlvqdlvqykfiysal
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 7-253 2.2e-52 172.8 In-house 37-273 (315) alignment 
Range on Protein: 7-253
Range on HMM: 37-273/315.0
NASRAAVNARKQRYRDIVAYDHTRVSLAAAGGHLGSDYINANYVVGYEKERAYIASQGPLPDTVGDFWRMAWEQTSRTIVMVAQVRENNRVKCELYWPA-
...|  .| .| ||..|. .|..|| |     .  |||||| |. ......|||||||||. .| ||||| ...   |||||.. .|....||  |||  
rvaretinfkknryknilPldsarvkleviddsPdsdyinasyiksvdddkayiasqgPlkasvddfwrmvlqekvttivmvtkkqegdkikcrqywPdr

VDHSATYGPLMVYGRREEVLSPNVTRRLfeIHhQDEDRVQEVVHLQMTTWPDHGSPRNPEAFLELHRRFREAqrnaRNSRSGPVglpIVHCSAGVGRSGT
  .|. .| . |     |  .  |.|.|  .  .. .  . |   |.| |||.|....  ..|.| .  .      ....  ..   .|||||||||.| 
kadsvefGsikvellsleadtdgvarkl..vt.rkseesrtvtqfqftewPdkGvdkqtssllklikevkad....ngkkefsl...lvhcsaGvGrtGv

FICLDTVFETLlAGRDPVEPLAIISRLRNCRNFMVQAVDQLDFIFRAI
.| .| | . . . .. |. . ..  ||. | ..||. ..  ||. |.
visidevvaqi.krtrsvdvfnfvknlrakrpylvqteeeyafiydav
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 11-253 1.2e-50 167.0 In-house 40-272 (515) alignment 
Range on Protein: 11-253
Range on HMM: 40-272/515.0
AAVNARKQRYRDIVAYDHTRVSLAAAGGHLGSDYINANYVVGYEKERAYIASQGPLPDTVGDFWRMAWEQTSRTIVMVAQVRENNRVKCELYWPA-VDHS
  .| .| ||..|. || .|| |        |||.|| |. ... ..||||||||.. .| ||||. ...   ||.||.. .|....||  |||     |
eeinfkknryknilPydsvrvklevindnPhsdyfnasyipsfdndkayiasqgPnkasvddfWrlvlqenvttiamvtklkegdkikcgkyWPdkpgds

ATYGPLMVYGRREEVLSPNVTRRLFEIHHQDedrVQEVVHLQMTTWPDHGSPRNPEAFLELHRRFReAQRNARNsrsGPVglpIVHCSAGVGRSGTFICL
  .| . |     |  .  . |.|  .. .|   .. |   ..| |||.|.|..  ..| | .  . |...  .    |.   |.|||||||| | .| .
vkfGsikvelvsleactggikrkltvlkgdd...srtvtqfhfteWPdkGvpkhtssllklikevk.adhgqyt...hpl...iihcsaGvGrtGvvisi

DTVFETLLAGrDPVEPLAIISRLRNCRNFMVQAVDQLDFIFRAI
| |      . . |. . ..  .|. | ..||. .|  ||. |.
dsvvahaktt.rmvdvfnfvtnirqkrpylvqtqeqyafiygav
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 3-252 1.6e-50 166.8 In-house 36-273 (287) alignment 
Range on Protein: 3-252
Range on HMM: 36-273/287.0
QHSANASRAAVNARKQRYRDIVAYDHTRVSLAaaggHLGSDYINANYVVGYEKERAYIASQGPLPDTVGDFWRMAWEQTSRTIVMVAQVRENNRVKCELY
...   . |  |  | |...|. .|  || |         ||||| .. ||....|.|....|. .|. .||.. ...   .|||..| .||.. .|  |
edevthniasqnkdknRltqilvpdnyrvllk....gehpdyinavfidgykekkafiiaesPmfntarnfWkliddrnvtaivmlcqekendeevcyqy

WPAVDHsATYGPLMVYGRREEvLSPNVTRRLFEIHHQD-EDRVQEVVHLQMTTWPDHGSPRNPEAF-LELHRRFREaqrnARNSRSGPVglpIVHCSAGV
||  .   ..|.  .    ||  . ... | .|..... ..  |.|.  |.|.|...|   .|..  | .......     | .  ...   .||||..|
Wpeeks.vvlGeyniellnee.vnagyierklevknknkagdkqqvkqyqitnWdstgkvtepqtillvieemykt....qrkrgntsi...vvhCsdtv

GRSGTFICLDTVFETLlAGRDPVEPLAIISRLRNCRNFMVQAVDQLDFIFRA
|||..|.  .|  .        .. . .. . |  .  .||.|.|  ||. .
Grsamfcaaattinkc.kteGviDvfqvlksqriqkpgsvqtveqykfindi
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 9-252 3.4e-50 166.0 In-house 43-283 (325) alignment 
Range on Protein: 9-252
Range on HMM: 43-283/325.0
SRAAVNARKQRYRDIVAYDHTRVSLAAAGGHLGSDYINANYVVGYEKERAYIASQGPLPDTVGDFWRMA--WEqtsRTIVMVAQVRENNRVKCELYWPAV
.    |  | |....||.|..|| | . .    ||||||.|.  . |   ..|.| ||..|..|.||..  |.    ..|.|  . ...  .|  |||  
amkpenkaknrfknvvaldksrvvletkkddpssdyinasylrddkkkdvflaaqaPltatindlWrlvldWr...csvvvvlneldlgkdrcavywpke

-DHSATYGPLMVYGRREEVLSPNVTRrLFEIHHQDEDRVQEVVHLQMTTWPDHGSPRNPEAFLELHRRFREAQRNARN--SRSGPVglpIVHCSAGVGRS
  .| |.|.| |  |  | .|  | |  ...   ..   . |  .|. .|.| | .. | ... . .   . .   .     |.|.   .|||||||||.
mgksktfGglevklrtieeisdyvhr.vldvkqvkkGetrsvkqfqlqswddmGvqkrpatlisilqlvkavservtantkastpi...lvhcsaGvGrt

GTFICLDTVFETLLAGrDPVEPLAIISRLRNCRNFMVQAVDQLDFIFRA
|.||.| .. . ..     |. .  . .||. |  ||..|||  .|. |
Gvfislysalakviee.srvdifgfvkklrkdrpsmvetvdqyiliyea
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 14-253 1.3e-49 163.6 In-house 3-235 (237) alignment 
Range on Protein: 14-253
Range on HMM: 3-235/237.0
NARKQRYRDIVAYDHTRVSLAAAGGHlgSDYINANYVVGYEK-ERAYIASQGPLPDTVGDFWRMAWEQTSRTIVMVAQVRENNRVKCELYWPAVDHSATY
|  |.|| .||||||.|| |  ||.   ||||||.|. |..   . |||.||||  .  |||.| |..    |||.. . |.|..||  |||  |  |.|
nkiknrygnivaydhsrvvlkgagsg..sdyinatylkgfdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywpstdqpaay

GPLMVYGRREEVLSPNVTRRLFEIHHQDEDRVQEVVHLQMTTWPDHGSPRNPEAFLELHRRFREaqRNARNSRSGPVglpIVHCSAGVGRSGTFICLDTV
| | |  ...| .|    | |   ...    |. .   |.|.|||.| |..  |.| . ..  .  |.   |.|||    |.||||||||.| |. .|..
gvltvslkkkeefsdytvrslllskrltlkevrlihqyqftswpdrgvpqqtaallrfrkniin..rsphvsesgpw...iihcsagvgrtgiflvidam

FETLlAGRDPVEPLAIISRLRNCRNFMVQAVDQLDFIFRAI
.      .  |.    .  . . | ...|. ||  ||...|
lrqa.kekkvvdiynyvysieedrpyiiqtkdqyvfihqti
subfamily_PTPRN_pd Subfamily PTPRN 5-252 3e-48 159.1 In-house 47-287 (297) alignment 
Range on Protein: 5-252
Range on HMM: 47-287/297.0
SANASRAAVNARKQRYRDIVAYDHTRVSLAAAGGHLGSDYINANYVVGYE-KERAYIASQGPLPDTVGDFWRMAWEQTSRTIVMVAQVRENNRVKCELYW
......|  |..|.|......|||.||.| .   .  ||||||  ..  . .. ||||.||||..|| |||.| ||| .  ||......|..  .|. ||
tkevakaeknvkknrskavlpydhsrvklkeeasaeksdyinasaildhdprapayiatqgplastvadfwqmvweqGvvvivnltrleeegvkqckryw

PAvDHSATYGPLMVYGRREEVLSPNVTRRLFEIHHQDEDRVQEVVHLQMTTWPDHGSPRNPEAFLELHRRFREAQRNarnsRSGPVglpIVHCSAGVGRS
|  . |..|.   |    | . . .   | | .   . .. . |  .   .||..| | .. ..||. |.   . |     || |.   .||||.|.||.
pd.eGsevyhiyevhlvsehiwcddylvrsfylknlqtsetrtvtqfhflswpeegvPasaksllefrrkvnksyrG....rscpi...vvhcsdGaGrt

GTFICLDTVFETLLAGRDPVEPLAIISRLRNCRNFMVQAVDQLDFIFRA
|..| .| | . || |   ..  | .  ||. |. .|.. ||..|.. |
GvyilidlvlnrllkGvkeidiaatlehlrdqrpglvktkdqfefalta
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 14-253 2.5e-47 156.3 In-house 48-275 (439) alignment 
Range on Protein: 14-253
Range on HMM: 48-275/439.0
NARKQRYRDIVAYDHTRVSLAAAGGHLGSDYINANYVVGYEKERAYIASQGPLPDTVGDFWRMAWEQTSRTIVMVAQVRENNRvkcelYWPAvDHSATYG
.  |.||.|..|.||||| |    |   | ||||||. || ... |||.|||  .|. ||||. .|. . ||||.... |  .     |||. |  . ||
dqtknrykdvgafdhtrvtlqeipgvphshyinanyikGyyddklyiatqgpkkettddfwrlviekktvtivmltnlvesyk.....ywps.daevcyg

PLMVYGRREEVLsPNVTRRLFEIHHQDED--RVQEVVHLQMTTWPDHGSPRNPEAFLELHRRFREAQRnarNSRSGPVglpIVHCSAGVGRSGTFICLDT
 ..|   |.  | || . | | .  . .   . . |.... ..|||.  | .    |.. |    |.    .   |||   .|||||||||.|| |.|| 
diavrvdrniel.pnyvirgfkvfnerdttekertvlqfhyiawpdknvpaqashvldflrainsand...keeygpv...vvhcsagvGrtGtiialdi

VFETLLAgRDPVEPLAIISRLRNCRNFMVQAVDQLDFIFRAI
 .| | .  . |.   |.. ||. |. ||||. |  ||. |.
aleqlkl.enkvdikgivkvlrkqrkqmvqalcqyvfiynav
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 9-253 8.5e-47 154.7 In-house 46-280 (297) alignment 
Range on Protein: 9-253
Range on HMM: 46-280/297.0
SRAAVNARKQRYRDIVAYDHTRVSLAAAGGHLGSDYINANYVVGYEKerAYIASQGPLPDTVGDFWRMAWEQTSRTIVMVAQVRENNRvKCELYWPAvDH
..  ||  |.||..|. ||  || ||  . .  |||.|| .| |...   .|..| | ..|| |||.| ...   ||||...  |... ||  ||.  . 
aekkvnfeksRYkniLPydssRvkLaivnddpdsDyvnasfvkgnkh..rlittqmPmkatvadfWamvldeqvstivmlnddnerdk.kcaryWsd.kg

SATYGPLMVYGRREEVLSPNVtRRLFEIHHQDEDRVQEVVHLQMTTWPDHGSPRNPEAfLELHRRFREAQRNARNSRSGPVglpIVHCSAGVGRSGTFIC
..|.| . |     .  .  . .| .|. ...    . |   | . |||.  .|. .|   |     | . .  .  .||.   .|||.||||| | .. 
vttfGdvsvvllsvsereGfi.krelevtkgkakarrvvkqyqfveWPdkaverkdsa.ssllklisevrkdfsqnaegPl...lvhclaGvGrtgvllt

LDTVFETLLAgRDPVEPLAIISRLRNCRNFMVQAVDQLDFIFRAI
.| |        . |. . ....||. | ..||. .|  |.. |.
idsvvaeakr.ekevdifglvkklrqerpylvqtkeqykfvyvav
subfamily_CG7180_pd Subfamily CG7180 12-250 7.1e-45 147.9 In-house 40-283 (296) alignment 
Range on Protein: 12-250
Range on HMM: 40-283/296.0
AVNARKQRYRDIVAYDHTRVSLAAAGGHLGSDYINANYVVGYEKERAYIASQGPLPDTVGDFWRMAWEQTSRTIVMVAQVRENNRvKCELYWPAVDhSAT
. |  | |. ..| ||..|| |   .|.  |||||| || .. |...||  ..|  .||..|||. ... . ..|..... . .. ..  |||     . 
kenreknrdvkvvPyDynRvvLekldGeeksdYinavyvdsflkkkeyivteapkketvdefWrlvydeeisavvvLtktfdfak.mypsywpnks.keq

YGPLMVYGRREEVLsPNVTRRLFEIHHQ----------DEDRVQEVVHLQMTTWPD-HGSPRNPEAFLELHRRFREAQRNA-RNSRSGPVglpIVHCSAG
||...|   .|. . .|.. | | . ..           .  .  | ..|.|.|.  .  |   .|..|| || |  ....  .   |||   .|..| |
ygeifveiveekqy.anlkirtfkltkkivalteqekqvkaetRivklfqlteWeledkvPlstnalielrrrvrlwrekvdedpeegPv...vvvssdG

VGRSGTFICLDTVFEtLLAGRDPVEPLAIISRLRNCRNFMVQAVDQLDFIF
..||| .. .|   | |.   . |.    . .||. |. .|. |..  .|.
asRsGvylaidanle.lvekeeevdvFeavktlrrsRpqLvenveeYkyiY
0041856 (Phosphotyrosine protein) phosphatases II 14-251 6e-44 145.1 In-house 1-165 (182) alignment 
Range on Protein: 14-251
Range on HMM: 1-165/182.0
NARKQRYRDIVAYDHTRvslaaagghlGSDYINANYVVGYEKERAYIASQGPLPDTVGDFWRMAWEQTSRTIVMVAqvrennrvkCELYWPavdhsatyg
|  | ||.||. |||.|          ..||||||...|. . . .|| ||||..|| ||.|| .|.  .|||...         .|||||         
nldknrysdilpydhsr..........dldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt.........eelywp.........

plmvygrreevlspnvtrrlfeihhqdEDRVQEVVHLQMTTWPDHGSPRnPEAFLELHRRFREaqrnarnsrsgPVGLPIVHCSAGVGRSGTFICLDTVF
                           |.  ....... . ||||| |  .. .|.. .. .|           . |  .|||||||||.||..... . 
...........................ellerlgiqylylpwpDhgvpd.ldelldfieevle...........eggpvlVHCsaGvgRtgtlvaaylmk

ETllagrdPVEPLAIISRLRNCRNFMVQAVDQLDFIFR
.        | .  ... .|..|. ||.  .|. |. .
kl......gvsleeavklvrsrRpgmvitpnqyfflql
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 6-252 7.7e-44 144.7 In-house 25-261 (283) alignment 
Range on Protein: 6-252
Range on HMM: 25-261/283.0
ANASRAAVNARKQRYRDIVAYDHTRVSLAAAGGhlgsDYINANYVV---GYEKERAYIASQGPLPDTVGDFWRMAWEQTSRTIVMVAQVRENNRVKCELY
|. . |  | ||.|...||..|  || | .       ||||| ...    |.... ||..|.|| .|| |||.| ...   .|||.....|..|.||  |
adiasadenkrknrnqeivpadqwrvelksesr....dyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfdekitaivmltklqedlrikCsqy

WPAvDHSATYGPLMVYgRREEVLSPNVTRRLFEIHHQ--DEDRVQeVVHLQMTTWpdhgSPRNPEAFLELHRRFREAQRNARNSRSGPVglpIVHCSAGV
||  . |  ||.. |   |.|. |   ..... ....   .. .  . | |.  |       ...| ..   .|   . . ..|. ||.   .||||.|.
WPk.rGsedyGeftvt.lrkettsnsfiikelllrvnssakstll.lahyqvidW....leygeqaiinslvkfnkvislqteskkgPi...vvhCstgi

GRSGTFICLDTVFETLLAgRDPVEPLAIISRLRNCRNFMVQAVDQLDFIFRA
||...|| . .  . .|.    |.  |..  .|. |  .||. ||  ..  .
Grtavfiaasasvkdalt.esvvdvfavvkimreqrmmavqtldqyklvhel
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 8-252 1.2e-43 144.0 In-house 2-236 (239) alignment 
Range on Protein: 8-252
Range on HMM: 2-236/239.0
ASRAAVNARKQRYRDIVAYDHTRVSLAAAGGHLGSDYINANYVVGYEK-ERAYIASQGPLPDTVGDFWRMAWEQTSRTIVMVAQVRENNRVKCELYWPav
|..  ||  |.|| .||.|||.|| |        ||||||.|.  |.   .||||.|| .  . |||||| |..    |||.. . |  . ||  |||  
aakkrvnkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywp..

DHSATYGPLMVYGRREEVLSPNVTRRlFEIHHQDEDRVQEVVHLQMTTWPDHGSPRNPEAFLELHRRFreaqrnARNSRSGPVGlPIVHCSAGVGRSGTF
| .. |  | |  |. ||..  . |  | . .  .   . | . ..| |||.| |.   | | |.|.       ...|  |     ..||||||||.|.|
dstskycnlrvtlrktevfadyiirt.fvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrki......tkdslpgarp.wvihcsagvgrtgaf

ICLDTVFETLlAGRDPVEPLAIISRLRNCRNFMVQAVDQLDFIFRA
. .|...      .  |. .  .  .|. | .|||. .|  ||. |
lvidamlrqa.kkqktvdifnyvkairedrphmvqtseqyvfihla
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 9-252 1.9e-43 143.4 In-house 2-235 (239) alignment 
Range on Protein: 9-252
Range on HMM: 2-235/239.0
SRAAVNARKQRYRDIVAYDHTRVSLAAAGGHLGSDYINANYVVGYEK-ERAYIASQGPLPDTVGDFWRMAWEQTSRTIVMVAQVRENNRVKCELYWPavD
..  ||  |.|| .||.|||.|| |        ||||||.|.  |.   .||||.|| .  . |||||| |..    |||.. . |  . ||  |||  |
akkrvnkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywp..d

HSATYGPLMVYGRREEVLSPNVTRRlFEIHHQDEDRVQEVVHLQMTTWPDHGSPRNPEAFLELHRRFreaqrnARNSRSGPVGlPIVHCSAGVGRSGTFI
 .. |  | |  |. ||..  . |  | . .  .   . | . ..| |||.| |.   | | |.|.       ...|  |     ..||||||||.|.|.
stskycnlrvtlrktevfadyiirt.fvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrki......tkdslpgarp.wvihcsagvgrtgafl

CLDTVFETLlAGRDPVEPLAIISRLRNCRNFMVQAVDQLDFIFRA
 .|...      .  |. .  .  .|. | .|||. .|  ||. |
vidamlrqa.kkqktvdifnyvkairedrphmvqtseqyvfihla
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 14-243 4.2e-43 142.0 In-house 56-269 (290) alignment 
Range on Protein: 14-243
Range on HMM: 56-269/290.0
NARKQRYRDIVAYDHTRVSLAAAGghlGSDYINANYVVGYEkeRAYIASQGPLPDTVGDFWRMAWEQTSRTIVMVAQVRENNRVKCELYWPAVDH-SATY
. .|.||.|.|  | ||| |   .     ||. |||| | .    .| .||.| ||| |.|||  ..   .|||. .. |. . ||| |.|  .    |.
efkknrykdvvcndktrvilkdGy...dGdyvhanyvkGlk..amfiltqGalkdtvidiwrmvlqekvaaivmlceliedGkakceqyypekeGevltf

GPLMVYGRREEVLSPNVTRRLFEIHHQDEDRVQEVVHLQMTTWPDHGSPRNPEAFLELHRRFREAqrnarnsrSGPVglpIVHCSAGVGRSGTFICLDTV
| . |    |.    |. .... . ..|. .   . ||.. .|||.  .    |.| . |  |.|        ||||   .||||||.||.|||. ... 
GeitvlcseeddkdaniikktlsvrdkdsGkehklkhlkikswpdksvalstlallrtlrilrka........sGpv...vvhcsaGiGrtGtfvaievg

FETLLAGRDpVEPLAIISRLRNCRNFMVQAV
 . || |.. ...| ..  |||.|   ||  
lqilldGke.ldlldlvralrnsrlnsvqvd
0051429 (Phosphotyrosine protein) phosphatases II 42-252 3.2e-41 137.1 In-house 4-220 (272) alignment 
Range on Protein: 42-252
Range on HMM: 4-220/272.0
SDYINANYVVGYEK---ERAYIASQGPLPDTVGDFWRMaWEQTSRTIVMVAQVRENNRVKCELYWP-----------AVDHSATYGPLMVYGRREEVLSP
|.||||..| || .   ......|.|||| |. ||||. .|.  .|||.. .. | .|.||..|||            .. . .|| |.|.   ||.|. 
sgyiNardvggygrvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseellld

NVTRRLFEIHHQDEDRVQEVVHLQMTTWPDHGSPRNPeaFLELHRRFREaqrnarnsrSGPVglpIVHCSAGVGRSGTFICLDTVFeTLLAGRDPVE---
 . |.|  ... . . . || ||..| ||||| |...  .||| . ...         .|||   .||||||..|.||...|. .    .   . |.   
yilrellltlllsagearevmhlhytdwpdhgvpqea..llellellld.........ggpv...lvHCsaGkdRTGtvvalllll.lgvsletivddYl

-----PLAIISRLRNCRNFMVQAVDQLDFIFRA
     .......|| .|  .||  .|. |...|
ltnlyleeaveelraqrpgavqteeqylflyea
0036282 (Phosphotyrosine protein) phosphatases II 41-250 8.3e-41 134.9 In-house 1-163 (174) alignment 
Range on Protein: 41-250
Range on HMM: 1-163/174.0
GSDYINANYVVGYEKERAYIASQGPLPdtvgdFWRMAWEQTSRTIVMVAQVRENNRVKCELYWPAvdhsatygplmvygrreevlspnvtrrlfeihhQD
|||||||... ...  . .||.||||.     ||.| .|. ..|.||. . .|....||  |||                                    
gsdyinaspldlsyitprliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe.................................lr

EDRVQEVVHLQMTTWPDHGSPRNPEaFLELHRRFREAQRNarnsrsGPVGLPIVHCSAGVGRSGTFICLDTVFETLLagRDPVEPLAIISRLRNCRNFMV
|| ........ . ||||| |  .. .||. .. .||. .      .| |  .|||||||||.||..... .   ||   ..|. |... .||..|  ||
edlerlgiqylylpwpDhgvpdlsi.llefvkfveealse......dpggpvlVHCsaGvgRtGtlvaaylmlrgll..eslvdaldlvrelRlqrpgmv

QAVDQLDFIF
|  .|. |. 
qtpsQyrfly
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 7-253 1.1e-39 131.0 In-house 38-232 (392) alignment 
Range on Protein: 7-253
Range on HMM: 38-232/392.0
NASRAAVNARKQRYRDIVAYDHTRVSLAAAGGHLGSDYINANYVVGYEKERAYIASQGPLPDTVGDFWRMAWEQTSRTIVMVAQVRENNrvkcelywpav
....  .| .|.||..|. || .|| |        |||.|| |. ... |.|||||||| . .. ||||| ...   ||.||....| .           
tvaqkeinlkknryknilpydsarvkleviddipdsdylnasyipsfdnekayiasqgpnaaslddfwrmvfqenvttiamvtklkegd...........

dhsatygplmvygrreevlspnvtrrlfeihhqDEDRVQEVVHLQMTTWPDHGSPRNPEAFLELHRRFreaqRNARNSRSGPVglpIVHCSAGVGRSGTF
                                   | .. |   ..| |||.. |.   ..|.. .      .    . . |.   |.||||||||.|  
.................................kgddartvaqfhftewPdkdvpkhtssllkfikev....kadfGqythpl...iihcsagvgrtgvv

ICLDTVFETLLAGRdPVEPLAIISRLRNCRNFMVQAVDQLDFIFRAI
|..|.|       |  |. . ... .|. | .|||. .|  ||. |.
isidsvvahakktr.mvdvfnfvtnirrkrpymvqtkeqyafiygav
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 11-253 2.7e-39 129.7 In-house 37-289 (301) alignment 
Range on Protein: 11-253
Range on HMM: 37-289/301.0
AAVNARKQRYRDIVAYDHTRVSLAAAGG--HLGSDYINANYVVGYEKERAYIASQGPLPDTVGDFWRMAWEQTSRTIVMVAQVRENNRVKCELYWPAV-D
   |.. .|...|. ||. |. |.          .||||.|. || .....||.|||.  |. ||||. |..   .||||.. .|. . ||| |||    
seenkalnrfknitvyddnriilkpkpnldlcqreyinasyidgysekkkfiaaqgpmkktlvdfWrliwqekpvsivmvtnlkegtkskceqywpnsea

HSATYGPLMVYGRREEVLSPNVTRRLF--------------EIHHQDEDRVQEVVHLQMTTWPDHGSPRNPEAFLELHRRFREAQRnarNSRSGPVglpI
.| ..||. |    | |.   | |.|               ... . .   ..|. ||.| ||..|  |.|   |.       .|.       |||   .
eseefgpftvtlvneqvyPdfvirqlnvkiqdgsnngyierkfkvksdksswdvlqlqvtdWpqdGvvreprtvLqviddvihrqq...kigggpv...v

VHCSAGVGRSGTFICLDTVFETLLAGRdPVEPLAIISRLRNCRNFMVQAVDQLDFIFRAI
||||..|.|||... ..   |   |    |.   .. ..|  .  .|.  .|  .|. .|
VHCSdtVsrsGvYcsvsiglEQckaeg.VVdvfqvtkavrrskpgaVtTLeqytsiydvi
subfamily_ptpA1_pd Subfamily ptpA1 13-208 1.3e-38 127.9 In-house 46-248 (418) alignment 
Range on Protein: 13-208
Range on HMM: 46-248/418.0
VNARKQRYRDIVAYDHTRVSLAAAGGHLGSDYINANYVVGYEkERAYIASQGPLPDTVGDFWRMAWEQTSRTIVMVAQVRENNRVKCELYWPAV---DHS
 |. |.|| .|.  .|||| |     . |||||||||. |    . .|..|||||.|. ||||| ||.  | |||...  || |.||. |||     .. 
hntsknrytnilpvnhtrvqlkkiqdkegsdyinanyidgay.pkqfictqgplpntiadfwrmvwenrcriivmlsresencrikcdrywpeqiggeqf

ATYGP-LMVYGRRE----E-VLSPNVTRRLFEIHHQDEDRVQEVVHLQMTTWPDHGSPRNPEAFLELHRRFREAQRNARNSRSGPVGLpIVHCSAGVGRS
. ||    |.|       | .  |.      .|.   |   ... . |   ||||  |   . | .| .   . | .   |    | . ||||||||||.
siygngnevfgtysvelveviqdpereiitrnirltfegetrditqyqyegwpdhnipdhtqpfrqllhsitnrqnqiipssdrnvpi.ivhcsagvgrt

GTFIC
|||  
gtfct
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 12-251 2.4e-38 126.9 In-house 39-271 (307) alignment 
Range on Protein: 12-251
Range on HMM: 39-271/307.0
AVNARKQRYRDIVAYDHTRVSLAAAGghLGSDYINANYVVGYEKERAYIASQGPLPDTVGDFWRMAWEQTSRTIVMVAQVRENNRVKCELYWPAVDH-SA
  |. |.||.|. . |..|. .   |  | |||| |||.    | . .|..|||| .|. .|| || ..   ...|...| |  ..||| |||...    
santdknryqdvkcqdkgrivvkfdg..lasdyihanylgiaikpkkficaqgplentqysfwamaiqekvesvimlckvielakikceqywpleegqkl

TYGP----LMVYGRREEVLSPNVT-RRLFEIHHQDEDRVQEVVHLQMTTWPDHGSPRNPEAFLELHrrfrEAQRNARNsrsgPVglpIVHCSAGVGRSGT
..|     . |     . |.|.     . ... .  .. . . ||| . |||.| |.   . ..|     || |  .|    ||   .||||||||||||
vfgeapntisvanlgakklapdedlinvttlkvdwaqksrtiqhlqwenwpdrgvpqinltainll....eavrydtn....pv...vvhcsaGvGrsGt

FICLDTVFETLLAGRDPVEPLAIISRLRNCRNFMVQAVDQLDFIFR
 ...  | . ..|| .  .   ..  ||. |.. .|.  |  .. |
ivaislvqdkmiaGinckdmkklveelrsqrhyaiqteaqylylhr
0046846 (Phosphotyrosine protein) phosphatases II 38-252 1.2e-37 124.7 In-house 8-168 (176) alignment 
Range on Protein: 38-252
Range on HMM: 8-168/176.0
GHLGSDYINANYVVGYekerAYIASQGPLPDTVGDFWRMAWEQTSRTIVMVAQVRENNRVKCELYWPAvdhSA---Tygplmvygrreevlspnvtrrlf
  |..||||||...|.    ..|| |||||.|. ||..| .|.  ...|.. . .| .|.||  |||                                 
ldldldyinanlilgs....rpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpe...leklgi.......................

eihhqdedrvqevvHLQMTTWPDHGSPRNpEAFLELHRRFREAQRNArnsrsgpvGLPIVHCSAGVGRSGTFICLDtvfetLLAGRDPVEPLAIISRLRN
              . . . ||||| |   |..||| .  |||...         |  .||||||.||.||.....     ||  .  . .. .....|.
..............qylhlpwpDhgvpdl.elllellefirealkeg........gpvlVHCsaGigRtgtlvaay.....llelekglsveealalvre

CRN-FMVQAVDQLDFIFRA
.|  ..||  .|. |. ..
qRplgavqtpeQyrflyef
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 6-165 1.8e-37 123.8 In-house 25-184 (297) alignment 
Range on Protein: 6-165
Range on HMM: 25-184/297.0
ANASRAAVNARKQRYRDIVAYDHTRVSLAaaGGHLGSDYINANYVVGYEKE--RAYIASQGPLPDTVGDFWRMAWEQTSRTIVMVAQVRENNRVKCELYW
  ...     || |||||.|.| ||| |   ..  ..|||||.|||  ..|    || .|||| .|| |||.. .||  |.|||||...|. | ||  ||
fssakrnsslrknryrdilatddtrvkll..rviterdyinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmvaklqedGrdkcapyw

PAVDHSATYGPLMVYGRREEVLSPNVTRRLFEIHHQDEDRVQEVVHLQMTTWPDHGSPRNPE
| |.      . .|     ..     .  | |..    .. . | | |  .||||| | . |
psvvqerlkagdvvveflsstsdefdrviltelqliyrsesrvvrhvqflswpdhGvpsdle
0049772 (Phosphotyrosine protein) phosphatases II 7-251 9e-37 122.8 In-house 39-274 (314) alignment 
Range on Protein: 7-251
Range on HMM: 39-274/314.0
NASRAAVNARKQRYRDIVAYDhTRVSLaAAGGHLGSDYINANYVVGYekeRAYIASQGPLPDTVGDF----------WRMA--WEQTSRTIVM-------
 ...  .|  |.|| ||. .| .|| |    .. |||||||.|| |.   ...||.||||. || ||          |||   ... .|.|||       
lvadlflnrdknryldilpad.nrvil.pglpvsgsdyinasyvdgf...lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivmsrdevla

--------------VAQVRENNrvkcelywpAVDHSATYGPLMvygrreevlspnvtrrlfEIHHQDEDRVQEVVHLQMTTWPDHGSPrNPEAFLELHRR
                .. .|.         .  . |..  |                   |... .|.  ......  . .||.. |  .| |.|. . 
delsrLdaAlgKtpllildgng.........neptaadlellk..................eelydpelferlgikylripvpDgsap.lledfdeflef

FREAqrnarnSrsgPVGLPIVHCSAGVGRSGTFICLDTVFETLlagrdPVEPLAIISRLRNCRN-----FMVQAVDQLDFIFR
..||      .   . |  .|||.||.||.|||.... .   |      | .  .....|..|       ...  .|. ||..
ieea......d...kggpvlvHCkaGkgRtgtfvvaaylmkll.....gvsleealedvrlkRpinpnpgfieqleqyefile
0043147 (Phosphotyrosine protein) phosphatases II 41-249 7.6e-36 118.8 In-house 4-153 (172) alignment 
Range on Protein: 41-249
Range on HMM: 4-153/172.0
GSDYINANYVVGYEKERAYIASQGPLPDTVGDFWRMAWEQTSRTIVMVAQVrennrvkcelywpavdhsatygplmvygrreevlspnvtrrlfeiHHQD
|||||||.|. .| . . .|| ||||. |. ||||| .|.  ..||.. .                                               .  
gsdyinasyldlyyipdrfiatqgplrntladfwrmlkelgithivnltel.............................................lydp

EDRVQEVVHLQMTTWPDHGSPrNPEAFLELHRRFREAQrnaRNSRSgpvGLPIVHCSAGVGRSGTFICLDTVFetllagrDPVEPLAIISRLRNCRNFMV
|. ........ . ||||| | ..| .||. .  .|..    .|..   |  .|||||||||.||..... .          . .. ... .|..|. .|
ellerlgiqylylpwpDhgvp.llellleflefidell...alspg...gpvlVHCsaGvgRtgtlvaaylml.......lglsleeavalvrekRpgav

QAVDQLDFI
|  .|. |.
qnpsqyrfl
subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 11-251 4.5e-35 115.7 In-house 34-263 (281) alignment 
Range on Protein: 11-251
Range on HMM: 34-263/281.0
AAVNARKQRYRDIVAYDHTRVSLAA-AGGHLGSDYINANYVVGYEKERAYIASQGPLPDTVGDFWRMAWEQTSRTIVMVAQVRENNRVKCELYWPAVDHS
  || .|.|| .| . | .|| |      .  .||| |||.     .| || .|||  .|  ||||| |.. . .|||..|. | || ||  |.|   | 
qpvnnkknrylnipcldisrvqlkvkmpnknstdyihanyirspflkrgyiltqgpkketradfwrmiwqenttaivmlcqfletnrekcaeyfprnahc

AT-YGPLMVYGRREEVLSPNVTRRLfEIHHQDEDRVqeVVHLQMTTWPDHGSPRNPEAFLELHRRFReaqrnarnSRSGPvglPIVHCSAGVGRSGTFIC
.  .  | |      |    || || .. .. | |.  . |     |||   |   | .|.. |. |        .|| |   |..|||||||||||...
clqfdklsvsyedstvnkslvttrl.nlsyegetrl..ithwlwkewpdwqvpessevmlkilrkir........arstp...pvihcsagvgrsgtlma

LDTVFETLLAGRDPVEPLAIISRLRN-CRNFMVQAVDQLDFIFR
..  .... .     .   |.|.||   |   ||...|  .|..
veialqsihshftlpdikqivshlrvtgraasvqtlqqymliwk
0049260 (Phosphotyrosine protein) phosphatases II 51-250 6.4e-34 112.2 In-house 3-143 (152) alignment 
Range on Protein: 51-250
Range on HMM: 3-143/152.0
VGYEKERAYIASQGPLPDTVGDFWRMAWEQTSRTIVMVAQVRENNRVKCELYWpavdhsatygplmvygrreevlspnvtrrlfeihhqdedrvqevvHL
 || . ...|| |||.| |. ||||| .|.  .||||. .  |....||| |.                                             . 
dgyampfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi.............................................qy

QMTTWPDHGSPRNPEAFLELHRRFREAqrnaR----NsrsgpvgLPIVHCSAGVGRSGTFICLDTVFetllagrDPVEPLAIISRLRNCRNFMVQAVDQL
. . ||||| | ... .|.|..  ...    .    .         .|||||||||.||..... .          |... .....|..|. .|.  .||
lhlpwpDhgvpdlsqlllflllfiekl....aldkgg.......pvlVHCsaGvgRtgtlvaaylml.......lgvsleeavalvrekRpgavpnpgql

DFIF
 |..
rfly
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 8-251 5.7e-32 105.7 In-house 42-281 (305) alignment 
Range on Protein: 8-251
Range on HMM: 42-281/305.0
ASRAAVNARKQRYRDIVAYDHTRVSLAAAGGHlgsDYINANYVVGYEKERAYIASQGPLPDTVGDFWRMAWEQTSRTIVMVAQVRENNRVKCELYWPAVD
| . | .| |.||.|.   |. || | ..  |   .|| ||||    . . .| .| || .|  ||| | ...   .| |. .. |    ||  |... |
afkeaqeagknrykdvgcldnnrvklegpwph...eyihanyvstptnpkrfictqaplektcadfwymclqdkveaifmlcnllekgakkcleyfaskd

HSAT-----YGPLMVYGR------REEVLSPNVTRRLFEIHHQDEdRVQEVVHLQMTTWPDHGSPRNPEAFLELHRrfreaqrNARNSRsGPVglpIVHC
.           ..|          ..  . .||.  . |    | ... | |     ||| | |    | |||         .|| |. ||.   .|||
kdvlefeekgqkisvkfessvtlkfrkdakakvtetvlviegpge.karkvthyhwidwpdrgvpaadlailelle.......karpsk.gpi...vvhc

SAGVGRSGTFICLDTVFETLLAGRDPVEPLAIISRLRNCRNFMVQAVDQLDFIFR
|||.||.|. . |. ... ||||.   .   |. ..|. ||  .|. .|  |. .
sagigrtgsvvmleyildqllagqiiedtdkilqkireqrnnsiqtdaqylfvhq
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 6-252 2.7e-31 103.3 In-house 48-284 (305) alignment 
Range on Protein: 6-252
Range on HMM: 48-284/305.0
ANASrAAVNARKQRYRDIVAYDHTRVSLAAAGghlGSDYINANYVVG-YEKERAYIASQGPLPDTVGDFWRMAWEQTSRTIVMVAQVRENNRVKCELYWP
|| | | ..  |.||.|. . |.. | |.       |||| ||||      |. .|..|||| .|. .|| |  ..    |||...  |  ..||  |||
anqs.adiaitknryqdvpcqdqsavkldkps...psdyihanyvgcpmipekrficaqgpldqtidefwwmviqnkveqivmlcktvelgklkcaqywp

AVDHS--ATYGPLM---VYGRREEVLSPNVTRRLFEIHHQDEDrVQEVVHLQMTTWPDHGSPRNPEAFLELHRRFReaqrnarNSRSgPVglpIVHCSAG
|         . ..   | | .     ...   |... .  ..    | ||| | ||| | |    . |||    |        |.  |.   .||||||
aaqgeklelksgivvenvsgskpmerdaeiqitllnltysgdq.kmsvrhlqwtewpdrgvppckltslellsair.......gskv.pi...vvhcsag

VGRSGTFICLDTVFETLlAGRDPVEPL-AIISRLRNCRNFMVQAVDQLDFIFRA
.||.|| .... ..| . |   |. |.  ..  ||. | | .|.  |  || | 
igrtgtivaieyileki.aenkpcppmpelvkalrdqrafsiqndvqylfihrv
0044763 (Phosphotyrosine protein) phosphatases II 26-251 4.1e-31 103.4 In-house 2-165 (178) alignment 
Range on Protein: 26-251
Range on HMM: 2-165/178.0
YDHTRVSLAAAGGHLGSDYINANYVVGYekerAYIASQGPlpdtvGDFWRMAWEQTSRTIVMVAQVRENNRVKCELYWPAVDHsatygplmvygrreevl
.|.|||.|    |...||||||......     |..|..|      |.... .|.  ..||....  |....||  |||   .                 
ldrtrvllsnleglersdyinaseilpg....lylgslpp.....addlellkelgithivnlteelelgflkcdpywpeeag.................

spnvtrrlfeihhqdedrvqevVHLQMTTWPDHGSPRNPEAFLELHRRFREAQrnarNSRSgpvGLPIVHCSAGVGRSGTFICLDTVFETllagrdPVEP
                      .. . . .|||| |  .| |||...  .||.    ...    |  .||||||||||||..... . .        . .
......................iqylhipipDhgvpdllehflefvefieeal....dekg...gpvlVHCsaGvgRsgtlvaaylmkkl......glsl

LAIISRLRNCRNfMVQAVDQLDFIFR
 ..|...|..|. .|.  .|| .. .
eeaielvrerRp.ivpnpgqlrqLye
0051082 (Phosphotyrosine protein) phosphatases II 42-251 2.1e-30 100.7 In-house 3-147 (151) alignment 
Range on Protein: 42-251
Range on HMM: 3-147/151.0
SDYINANYVVGYekeraYIASQGPLPdtvgDFWRMAWEQTSRTIVMVAQVRENNrvKCELYWPAVDhsatygplmvygrreevlspnvtrrlfeihhqde
|||||..|| |.     ...|.|||.    ||... .|.  .|||.. .  |..  .|  |.|. .                                  
sdyinfsyvtgg.....lyrsggpla....dflellkelgiktivnlrseeerg..ycpeylpelg..................................

drvQEVVHLQMTTWPDHGSPRNPEAFLELHRRFREaqrnarnsrsGPVGLPIVHCSAGVGRSGTFICLDTVFETllagrdpVEPLAIISRLRNCRNFMVQ
    ||.|.... |||.| | ...|.||... ...           . |  .||||||.||.||...|. . .        | . .... .| .|  .||
...ievlhipildwpdpglplsfdavleflellld..........kkngpvlvHCsaGkgRTGtlvalylmllg.......vsleealeeyrlkrpgvvq

AVDQLDFIFR
  .|  |...
pnqqflfqlf
subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 14-247 3e-28 93.3 In-house 52-280 (310) alignment 
Range on Protein: 14-247
Range on HMM: 52-280/310.0
NARKQRYRDIVAYDHTRVSLAAAGGHLgSDYINANYVVGYEKERAYIASQGPLPDTVGDFWRMAWEQTSRTIVMVAQVRENNRVKCELYWPAVDHSATYG
.  |.|| |.|  | .|| |         ||| ||||       ..| |||||  |. ||||| ... . .|... .| |. | ||  |||..  . |||
ymhknrysdvvcldtsrvklkidksry.edyihanyvktnylrstficsqgplqhtiidfwrmifqeraesilllckvgeegrpkcvgywpslgvtetyg

PLMVYGRRE---E--VLSPNVTRRLFEIHHQDEDRVQE---VVHLQMTTWPDHGSPRNpeaflelhRRFREAQRNARNSRSGPVglpIVHCSAGVGRSGT
 . |    |   |  .    ||    ..  ...    .   |  ..   ||| | | .        .     ||   . | ||.   .||||||..| ..
cirvtnlsesseefeicnlavtfvpdnvpvdeqpanlkelrvslikwpnwpdrgvpde........kchtvpqrllaqvrhgpc...vvhcsagkdrlyv

FICLDTVFETLLAGrDPVEPLAIISRLRNCRNFMVQAVDQLD
 . |.  .. |  | . |.   ... |.. |   .|.  |  
vvalklkidkldrg.lkvdaeevktellksraiciqtelqyl
subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 8-248 8.7e-27 88.6 In-house 44-272 (301) alignment 
Range on Protein: 8-248
Range on HMM: 44-272/301.0
ASRAAVNARKQRYRDIVAYDHTRVSLAAAGGHLGsdyINANYVVGYEKERAYIASQGPLPDTVGDFWRMAWEQTSRTIVMVAQVRENNRVKCELYWPAVD
 | | ..  |.||  .    .| | . . |  .    | ||..    . . .||.||||..|  ||| |       .|||..| .|..  ||| | |   
esyaylpkdkhryptvPckPstavevivdGkrvP...ihanwiptsGhphrfiatqgPlkntsedfwamlvqydvekivmlgqkvekleekceeylpvki

-HSATYGPLMVY-GRREEVLSPNVTRRLFEIHHQDE-DRVQEVVHLQMTTWPDHGSPRNPEAFLELHRRFREAQRnarnsrsgPVglpIVHCSAGVGRSG
 ..   |  ..    .| .|. ....| .|..   .    . |.| | ..|.|.| |.      .|    .....        |.   .||||||.||| 
sekldigrfkikiknkelilnkkiskrtlevedstgkfatrtvthyqysewtdrgvPkshaelfdlmelvkksek........Pi...vvhcsaGiGrsv

TFICLDTVFETLLAGRDpVEPLAIISRLRNCRNFMVQAVDQLDF
.||  . .   ..| .  .|    . .||. |   || . || .
afigteylareveadpt.ieltealkhlrehrwngvqtnsqlyw
PTPc_DSPc_SM00012 147-253 1.2e-26 88.3 In-house 2-103 (105) alignment 
Range on Protein: 147-253
Range on HMM: 2-103/105.0
VVHLQMTTWPDHGSPRNPEAFLELHRRFREAQRNARNsrsgpVGLPIVHCSAGVGRSGTFICLDTVFETLLAGRDPVEPLAIISRLRNCRNFMVQAVDQL
| |...|.||||| |......||| | ... .... .      .  .|||||||||.|||..||.. . | .... |. . |...||. |. |||  .| 
vkhyhytgwpdhgvPeesdsilellravkknknkses.....skpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqy

DFIFRAI
 |. ||.
lflyral
subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 13-250 2.8e-26 87.1 In-house 34-263 (285) alignment 
Range on Protein: 13-250
Range on HMM: 34-263/285.0
VNARKQRYRDIVAYDHTRVSLAAaggHlGSDYINANYVVGYEKE-RAYIASQGPLPDTVGDFWRMAWEQTSRTIVMVAQVRENNRVKCELYWPA-VDHSA
 |   .|| |. . . ||| |     |   ||| |...    |.  .||..|||||.|. |||.| ...    ..|.. . |    || ||.|  .    
anpdlnryadvrcieetrvvlkn...h.drdyihaswmrmpgkdqstyittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekcalyypeklgevv

TYGPL--MVYGRREEVLSPNVTRRLFEIHHQDEDR-VQEVVHLQMTTWPDHGSPRNPEAFLELHRRFREAqrnarNSRSGPVglpIVHCSAGVGRSGTFI
 .|     .   .|| ..  .   |  |  .|       . |.|.  |||. .| .   ..||..  ..      | .  |.    |||||||||. ||.
kfgkyeitlteckeeaiagtilnaltvintedasseplymnhvqvpwwpdqlapedarpmielykwvkkv.....npkekpi...cvhcsagvgrtatfv

CLDTVFETLLAgRDPVEPLAIISRLRNCRNFMVQAVDQLDFIF
 .|     ..     .| | |.  .|  |   ||.  |. |..
gidyatirime.npniemldivremramrfqavqshmqflfly
subfamily_CG42327_pd Subfamily CG42327 15-170 6.2e-26 85.8 In-house 29-186 (319) alignment 
Range on Protein: 15-170
Range on HMM: 29-186/319.0
ARKQRYRDIVAYDHTRVSLAAAGGHLGSDYINANYVVGYEKE-RAYIASQGPLPDTVGDFWRMAWEQTSRTIVMVAQVRENNRVKCELYWPA---VDHSA
  |.|. ..|   .||| |   | .  . |..|.|| ||..    |||.| .| |.  ||||. ||| ||.|| .... |.   .|  |.|.    |   
kdksrvinvvPlPetrvvlqrigdddkdeyldasyvrGyddapnsyiaaqvsledsssdfwrtvweqqsrvivqltdlselGikvcaeylPtketldnts

TYGPLMVYGRREEVLSPNVTRRLFeIHHQDEDRVQEVVHLQMtTWPDHGSPRNPEAFLEL
.|| ..|  .  ||    ..  |  ... |..  .|. |     |.. . | ...|.. .
lyGdilvtlkgrevkdryaistll.lkrvdkeesrelthywy.kwleaevPaeeaaliam
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 8-250 9.7e-26 85.3 In-house 27-252 (267) alignment 
Range on Protein: 8-250
Range on HMM: 27-252/267.0
ASRAAVNARKQRYRDIVAYDHTRVSLAAAGGHlgsdYINANYVVGYEKERAYIASQGPLPDTVGDFWRMAWEQTSRTIVMVAQVRENNrvkCELYW-PAV
 | |  |. ..|. | . ||.||| |          |||| || ||....|.|. |.||  |..||. .  .|   .||.. .| ..|     |.| | .
qsiaeknqernrlddnlpyddtrvilrtkeee....yinasyvegyktknafivtqdplkntitdfltvihdqkvpvivlltkvftdn...irlfwPPkm

DHSATYGPLMVYGRREEVlSPNVTRRLFEIHHQDEDrVQEVVHLQMTTWPDHgspRNPEAFleLHRRFREAQRNARNSRSGPVglpIVHCSAGVGRSGTF
 ..  |  | |    |.    .     .|.. ..|   ..|.      |       | . .  |.  |    .|  .  . |.   .|.||.||||||||
gqakkyqdltvehsleke.endyqiitlelkfknes.ahnvtlyyykkwnin...tnnkpy..lkplfgilaknqlengnrPl...vvacsdGvGrsGtf

ICLDTVFETLLAgRDPVEPLAIISRLRNCRNFMVQAVDQLDFIF
. .|. .| .    . ..    . ..|. |  .|.. ..  .| 
lvidsqlerakt.egvsdifdflrkirsqriglvdtkeryiyih
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 14-252 1.8e-25 84.6 In-house 43-266 (288) alignment 
Range on Protein: 14-252
Range on HMM: 43-266/288.0
NARKQRYRDIVAYDHTRVSLAaaggHLGSDYINANYVVGYEKERAYIASQGPLPDTVGDFWRMAWEQTSRTIVMVAQVRENNRVKCELYWPAVDH-SATY
|. ..||...   | ||| |          ||.|| |   . .|  | .| ||  |.. .|.|  |.  . |||.... |  . | . |.| .   .| .
nptrdryenlprcditrvkls....ddpdfyiaanvvssakykrrlicaqaPlngtieelWkmllesdveyivmlcellekGkeksaeyfPsklGekari

GPLMVYGRRE-EVLSPNVTRRLFEIHHQDEDRVqEVVHLQMTTWPDHGSPRNPEAFLELHRRFreaqrnarNSRSGPVglpIVHCSAGVGRSGTFICLDT
| |    ... . .   |.  |. |... |..|  | .| .  |.|.| | |  ..| |  ..        .|   |.   .||.||||||.||.|    
grlctvvkkkradidklvkvsllriskegeekv.ivkilhlleWdddgvPenylsplrllevl........kslqkPi...vvhssaGvGrtgtlilili

VFETlLAGRDPVEPLAIISRLRNCRNFMVQAVDQLDFIFRA
. |. |   | .    ....||. |   .|.  |  ...| 
ales.lrlddflgirsllaklreerfkaiqtemqylyvhrc
subfamily_egg_pd Subfamily egg 7-253 9.3e-25 81.9 In-house 33-266 (307) alignment 
Range on Protein: 7-253
Range on HMM: 33-266/307.0
NASRAAVNARKQRYRDIVAYDHTRVSLAAAGGHLGSDYINANYVVGYEKERAYIASQGPLPDTVGDFWRMAWEQTSRTIVMVAQVRENNRvkCELYWPAV
. . .. |  | | . .   | .|| |    |    |.| ||.| |      .| .| || .|| ||||| ...  . |||..  .|..|  || |||  
ttaasdnnlekarskrvhckdssrvklelrrGqylddfihanrvkGkpllnefilaqaplkntvddfwrmvfqeevqyivmltsrkeser..ceyywpka

D-HSATY--GPLMVygrrEEVLSPNVTRRLFEIHHQDE---DrvQEVVHLQMTTWpDHgsprnpEAFLELHRRFReAQRNARNSrSGPVglpIVHCSAGV
. .|. .  | | .    | .   . .  || . .      |  .|  .|.   . |       .   ...  .|   | .||  | ||   .|..  ||
esdslvtvpGslri....enlkvdskadplfrvtklklvGgd..deerflehwqg.dv......nnssdvysplr.vlrklrnl.skpv...vvqdilGv

GRSGTFICLDTVFETLLAGrdPVEPLAI---ISRLRNCRNFMVQAVDQLDFIFRAI
 ...|...... . .|| |  |.    .   .  ||  |.. |..| .  |..| .
skaatlvaieiallsllrG..pitkslvlravvflrlrrrlsvesvllylfvyrlv
subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 56-251 2.5e-23 77.3 In-house 4-198 (199) alignment 
Range on Protein: 56-251
Range on HMM: 4-198/199.0
ERAYIASQGPLPDTVGDFWRMAWEQTSRTIVMVAQVRENNRVKCELYWPAVDHSA-TYGPLMVYGRrEEVLSPNVT--RRLFEIHHQDEDRVQEVVHLQM
.| |||.| || .|. |||.| ||  |  |||| . . |. .   .|||... ..  || | |  .   .  |. |    ..          .|. | |.
qrryiatqhplretmadfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttk.tittkpdytitaliltnnttappstreishyqf

TTWPDHGSPrNPEAFLELHRRFREAQRNARNSRSGPVglpIVHCSAGVGRSGTFICLDTVFETLLAGRDP-VEPLAIISRLRNCRNFMVQAVDQLDFIFR
|.| .. .| |   |. .    ||  ..  . .  ||   ||||| | | .| |..||    .    .   |. . .  |||..|  .. .... .||..
tswkekttp.nvalfvgfvvasrevskkyeqekdapv...ivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiyq
subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 56-251 3e-23 77.0 In-house 3-197 (198) alignment 
Range on Protein: 56-251
Range on HMM: 3-197/198.0
ERAYIASQGPLPDTVGDFWRMAWEQTSRTIVMVAQVRENNRVKCELYWPAVDHSA-TYGPLMVYGRrEEVLSPNVT--RRLFEIHHQDEDRVQEVVHLQM
.| |||.| || .|. |||.| ||  |  |||| . . |. .   .|||... ..  || | |  .   .  |. |    ..          .|. | |.
qrryiatqhplretladfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttk.tittkpdytitaliltnnttappstreishyqf

TTWPDHGSPrNPEAFLELHRRFREAQRNARNSRSGPVglpIVHCSAGVGRSGTFICLDTVFETLLAGRDP-VEPLAIISRLRNCRNFMVQAVDQLDFIFR
|.| .. .| |   |. .    ||  ..  . .  ||   ||||| | | .| |..||    .    .   |. . .  |||..|  .. .... .||..
tswkekttp.nvalfvgfvvasrevskkyeqekdapv...ivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiyq
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 16-109 1.4e-22 74.9 In-house 49-156 (350) alignment 
Range on Protein: 16-109
Range on HMM: 49-156/350.0
RKQRYRDIVAYDHTRVSLA--------AAGGHLGSDYINANYVV----GYEKERA--YIASQGPLPDTVGDFWRMAWEQTSRTIVMVAQVRENNRVKCEL
 | ||..|. |.|.|| |             . ..|||||||.     . | .    ||| |.||| || ||...  .   . |.....  |.|. ||. 
aknrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvkvilsltsdvelnlekcyr

YWPAVDHS
||.  . .
YWqegsyd
0048076 (Phosphotyrosine protein) phosphatases II 111-251 3.1e-21 71.0 In-house 12-137 (145) alignment 
Range on Protein: 111-251
Range on HMM: 12-137/145.0
TYGPLMVYGRREEVLSPNVTRrLFEIHHQDEDRVQEVVHLQMTTWPDHGSPRNPEAFLELHRRFREAQRNarnsrSGPVglpIVHCSAGVGRSGTFICLD
 .|.| .  ..|.  . ..|. .. . .  |. ........ . ||||| |  .| .||. .  .||...      |||   .|||||||||.||.....
ylgslptaldlellkdlgitt.vlnltselellerlgiqylylpwpDhgvpdllellleflefieealke.....ggpv...lVHCsaGvgRtgtlvaay

TVFEtllagrDPVEPLAIISRLRNCRNFMVQAVDQLDFIFR
 ...        | .  .. ..|..| ..|. ..|| |...
lmll......lgvsleealelvrsqrpgavpnpgqlrflye
subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 17-251 1.6e-20 68.5 In-house 22-253 (290) alignment 
Range on Protein: 17-251
Range on HMM: 22-253/290.0
KQRYRdIVAYDHTRVSLAAAGGHLGSDYINANYVVgYEKERAYIASQGPLPDT-------VGDFWRMAWEQTSRTIVMVAQVRENNRV----KCELYWP-
.||.. .    .||| |   | .. .||| ||.|  . .  . |..| |. ..       . .|| || .  .. .||. .. |...      |. | | 
dqRle.vpLveatrvvLkgygkrfnddyiHAnrvt.cpnglrliltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCakYvpe

AVDHSATYGPLMVYGrREEVLSPNVTRRLFEIHHQDEDRVqEVVHLQMTTWPDHGSPRNPEAFLELHRRFreaqrnarNSRSGPVglpIVHCSAGVGRSG
.|. . ... | |    . .   .| .|  .....||     | | ..  | .   ....  .|.| .          . .  ||   ||||  |. || 
svgeelkfkgltvkC.kskekeddvetRelvvkfddeeef.tvtHsllkgWnklnvqedtktllsliqkv........kasktpv...ivHcvdGiSrsA

TFICLDTVFETLLAGRDPVEPLAIISRLRNCRNFMVQAVDQLDFIFR
..  ..  .  .   .. |.  .... ||. |. ...   .| |.  
alaaiilgyQkiaetsgsvkledvlkalrkqralaitsalelafvda
subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 18-251 4.6e-20 66.6 In-house 47-270 (312) alignment 
Range on Protein: 18-251
Range on HMM: 47-270/312.0
QRYRDIVAYDHTRVSLAAAGghlgSDYINANYVVGYEKERAYIASQGPLPDTVGDFWRMAWEQTSRTIVMVAQVRENNRVKCELYWPAVDHSATYGPLMV
.|| .|  .|  | .||         || ||.|    |   ....|||| .|.  ||..|   .| .|.... . |.   ||  |   .          |
nrypniqcwdrgrftlagde....nfyihanfvkictkperfvctqgplentcthfwqlalslgstsiillcgfvedgsekcakyisdivgfvdledhrv

YGRRE---EV---LSPNVTRRLFEIHHQDEDRVQEVVHLQMTTWPDHGSPRNPEAFLELHrrfrEAQRNARNsrsgPVglpIVHCSAGVGRSGTFICLDT
|       |.      ..| |.. .  .   .   . | | ..||||| |   .. | |      | .. ..    ||   | ||||||||.||.. ...
yteycteieiggkskdkithrvlkvvvkatgqesklnhyqwaswpdhgmpdscdtalrll....savkkdkk....pv...iahcsagvgrtgtlalies

VFETLLAGRDPvEPLAIISRLRNCRNFMVQAVDQLDFIFR
.  .|   |   .   .   ||. |   |... |  . .|
miaalrhprkq.nvkdsfvllrkdrarsvrvfpqyvyalr
0048179 (Phosphotyrosine protein) phosphatases II 140-250 1e-19 66.1 In-house 42-138 (144) alignment 
Range on Protein: 140-250
Range on HMM: 42-138/144.0
DEDRVQEVVHLQMTTWPDHGSPRNPEAFLELHRRFREAQRnarnsRSGPVglpIVHCSAGVGRSGTFICLDTVFetllagRDPVEPLAIISRLRNCRNFM
 |.  .|..... . ||||| |  .| .||. . ..||..     ..|||   .|||||||||.||..... ..      .  . .  .. ..|..| ..
pefleregiqylhlpwpDhgvpdllellleflefieeale.....eggpv...lVHCsaGvgRtgtlvaaylmk......klglsleealalvrsrrpga

VQAVDQLDFIF
|.  .|| |. 
vpnpgqlrfLl
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 52-157 8.3e-18 58.9 In-house 231-330 (440) alignment 
Range on Protein: 52-157
Range on HMM: 231-330/440.0
GYEKERAYIASQGPLPDTVGDFWRMAWEQTSRTIVMVAQVrenNRVKCELYWPAVDHSATYGPLMVYGRREEVLSpNVTRRLFEIHHQDEdrVQEVVHLQ
|| |  |.||.| ||  || ||||.  .    ||.|. |.   |   | .|||    | |.||. |  .  | .   |  | .|.....|  |.|.  ..
gyskknafiatqmpldstvldfwrlvhdyristiimlnql...ndktcsiywpvntrsvtfgpftvghkgsenmn.rvkvrtlelkykee..vheirqfe

MTTWPD
. ||| 
vqtwpt
subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 61-221 6.4e-17 56.5 In-house 39-180 (255) alignment 
Range on Protein: 61-221
Range on HMM: 39-180/255.0
AsqgplpdTVGDFWRMAWEQTSRTIVMVAQVRENNRVKCELYWPA-VDHSATYGPLMVYGRReevLSPNVTRRLFEI--HHQDEDRVQEVVHLQMTTWPD
        ||  |...   . . ..||..   |....||. |.|   |    .  . |   .    | .|  |  ||  .  .  . ..| | . . |..
l.......tvdkfyqtivqtktevvvmlcdfaeegvekcssyfplekdeklkladvnvtttk...ssadvvlrtleitstlgekkkthtvkhysykGWie

HGSPRNPEAFLELHRrfreaqrNARNSRSgpVglpIVHCSAGVGRSGTFICLDTVFETLLAGRD
. .|....  |.. .        .|.|.|  |   .||||.|.||| .|.  . |. ...   |
knaPelareilnilk.......vvrdsks..v...vvhCstGiGrsaafvlaelvyqkmirsld
subfamily_eak_pd Subfamily eak 19-253 1.1e-16 55.1 In-house 56-301 (332) alignment 
Range on Protein: 19-253
Range on HMM: 56-301/332.0
RYRDIVAYDHTRVSLAAAGgHLGSDYINANYVVGYEKERAYIASQGPLPDTVGDFWRMAWEQTSRTIVMVAQVRENNRVKCELYWPAVD-HSATYGPLMV
   .|| ||.  | |...       ||||  .   |  | || .  .  | |  ||.|  || | .||....  |..  | . |.|    .   .| | |
nvvkivpydrylvrltssq.lnrlGyinaslaefsevGrkyiltGiasedkvfafwqmvleqkspaivqlledvelkleksdkyfpdktreelkfGildv

YgRREEVLSPNVTRRLFEIHHQDEdrVQEVVHLQMTTWPDHGSPRNpEAFLELHRRFREAQR-------NA-------RNSRSGPVGLPIVHCSAGVGRS
  |.| |   ..  ||.|..  .|    .| | ..  | .   |.  | || |..  .|.         .|       .   . |   ||. .. |  |.
e.rkefvkrniletrllelskGne..thrvlhykvfGwtettlpky.edflalrkvmkevGvlllivmksallsstlkkyihtppsfapiiqsarGsara

GTFICLDTVFEtLLAGRD----PVEplAIISRLRNCRNFMVQAVDQLDFIFRAI
|.|. .| . . |. ..      ||   .| . .. |.  | .  |  ||. ..
Gvfvvidllir.lidnkkknlysve..dlilkvkskrihsvlvalqhsfiyeiv
subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 13-251 1.2e-16 55.2 In-house 46-273 (303) alignment 
Range on Protein: 13-251
Range on HMM: 46-273/303.0
VNARKQRYRDIVAYDHTRVSLAAagghlgSDYINANYVVGYEKERAyIASQGPLPDTVGDFWRMAWEQTSRTIVMVAQVRENNRVKCELYWPAVDHSATY
 |  |.|. |..  ||..| |.       | || |.|.    . .| | .| ||. |  |||.|  ||  . ....    | ...  .  .|  .    .
knmdknrfvdvicldhskvklsd......ssyihasyleldsskka.iltqlplshtaadfwqmiieqkvkcvlllltdseydklggdsvfprnqdflkf

GPLMV-YGRREEV-LSPNVTRRLFEIHHQDEDRVQEVVHlqMTTWPDHGSPRNPEAflELHRRFREAQRNARNSRSGpvgLPIV-HCSAGVGRSGTFICL
   ..  |   .| |.   . ..  .   |      | |    .||    | .  .  .. ..  . |   |.   .    | |    .|.||.|||  .
eersirvgefkrvelgdgwvlkvlsvsngdyksflhvhh..ykawphnsipsdgsp..kfvkqiwqlqsvlrkysds...tptvymslsgcgragtfalf

DTVFETLLAGRDPVEPLAIISRLRNCRNFMVQAVDQLDFIFR
.|   .| . .  .. .  .  .|| |   || . |. ... 
etahlslhseqasldlvkclenvrngrlhavqnlsqfsvvyt
subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 63-250 6.4e-16 52.7 In-house 97-281 (302) alignment 
Range on Protein: 63-250
Range on HMM: 97-281/302.0
QGPLPDTVGDFWRMAWEQTSRTIVMVAQVRENNRVKCELYW-PAVDHSATYGPLMVYGRR-EEVLSP---NVTRRLFEIHHQD---EDRVQ-EVVHLQMT
  |  .|.  .| .  .     .| .... |..  ||  |.   |.   ..|   |     .. |.      . .|. .  ..   ...|.  |  |. .
ivpkkstlekhwalieqynvaivvqlcsfvedeekkcaeyysdkvggelkfgrytvktvsvktdleeftdkksfklytveiknekkkkkvkktvdilafs

TWPDHGSPRNPEAFLELHrRFREAQRNArnsrsgpVglpIVHCSAGVGRSGTFICLDTVFEtLLAGRDPVEPLAIISRLRNCRNFMVQAVDQLDFIF
.|||||.|..... |..  .| |. ...       |   .|||||||||.||.. .    . | . ..  . | |.  .|.||   ||  .|| ...
awpdhGapkeaytaldil.kfcesykkn.......v...lvhcsaGvGrtGtlvaikyGiq.lcskkkvtdllsivlpvrqcryGavqdeqqliyll
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 16-109 5.6e-14 46.2 In-house 50-159 (349) alignment 
Range on Protein: 16-109
Range on HMM: 50-159/349.0
RKQRYRDIVAYDHTRVSLAA--------------AGGHLGSDYINANYV--VGYEKERAYIASQGPLPDTVGDFWRMAWEQTSRTIVMVAQVRENNRVKC
 | ||.||. |.|.|| |                . .    |||||||.    .. |. ||| | ||| || ||...   .  . .. . .  |..  ||
aknrykdilPyehsrvklkkslksskvikastsesdsgklddyinanylkltrisvekkyiatqaPlPstvddfykvillngvklvlsLnddkelslekc

ELYWPAVDHS
. ||   ..|
diywqelsys
subfamily_hpo-7_pd Subfamily hpo-7 66-220 8.9e-14 46.0 In-house 43-185 (263) alignment 
Range on Protein: 66-220
Range on HMM: 43-185/263.0
LPDTVGDFWRMAWEQTSRTIVMVAQVRENNRVKCELYWPA-VDHSATYGPLMVYGRREEVLSPNVTRRLFEIHHQdEDRVQEVVHLQMTTWPDHGSPRNP
| .|.  |...   . . ..||..   |....||. |.|   |    .  . |   .        |. | ..  .   ....| | . . |...  |...
lvqtidkfyqtivqtktevvvmLcDfneegvekcssyfPlekdekqklanvnvcttkvqsdvllktlellstlge.KkkthtvkhysykgWiekndpela

EAFLELHRrfreaqrNARNSRSgpVglpIVHCSAGVGRSGTFICLDTVFETLLAGR
.  |.. .        ||||.|  .   .||||.|.|||  |   ..|. ...   
reilnilk.......varnsks..l...vvhcstGiGrsaafsvaElvyqkmirsl
subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 14-252 4.7e-13 43.2 In-house 51-280 (302) alignment 
Range on Protein: 14-252
Range on HMM: 51-280/302.0
NARKQRYRDIVAYDHTRVSLAAAgghlGSDYINANYVVGYEKERAYIASQGPLPDTV---GDFWRMAWEQTSRTIVMVAQVRENNRvKCELYWP-AVDHS
| .|..  |. ..|...| |.|.      .|.||  |   | .|  | .| |  |..    .||||....   ..|....  | ..   . ..|   .  
nlkknqsedvpildsnlvkleae....pdsyvnaskvevPeltrsiilaQlpkvdsedsveeFWrmvfqekivsvvilvgeeelkk.tlselfpkksgdy

ATYGPLMVYGRREEVLSPNVTRRLFEIHHQDE--DRVQEVVHlqMTTWPDHGSPrnpEAFLELHRRFREAQRNARNSRSGPvglpIVHCSAGVGRSGTFI
 .|| ..|  |. |  . ..||   |.  ..     . .| .  .| |...  |   . . || .   .   .  .. .      ..    |.|| |.|.
keygkmfvNnrkVekaeeektryviEvlPegcsnsvlanvyv..ltnWkqkkvp...vkyaeliktaakvfakkikadent....vivSknGaGRagafl

CLDTVFETLLAGrDPVEPLAIISRLRNCRNFMVQAVDQLDFIFRA
 | ...|.| .| . ..   |.  .|. |  .|....|  ....|
tlavaveklqkg.kepnikeivksiRsqRpravdslkQyvslyia
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 150-252 1.1e-11 38.8 In-house 94-189 (440) alignment 
Range on Protein: 150-252
Range on HMM: 94-189/440.0
LQMTTWPDHGSPRNPEAFLELHRRFREAQRNARNsrsGPVglpIVHCSAGVGRSGTFICLDTVFETLlAGRDPVEPLAIISRLRNCRNFMVQAVDQLDFI
 ..  |||.| |.     |.. .   |.| .| |   ||.   .||||||.||.|  |..|...       | .. ...|. .|| |  |||. .|  |.
yhyqgwpdkgvpkfagpvlkmiqdvnesqekagn...gpl...lvhcsagagrtgviiavdsilrea.krsdqidifsfinsmrnnrpqmvqtpeqyafv

FRA
. |
hea
subfamily_Cele-PTP-12_pd Subfamily Cele-PTP-12 16-99 1.5e-11 38.3 In-house 36-118 (332) alignment 
Range on Protein: 16-99
Range on HMM: 36-118/332.0
RKQRYRDIVAYDHTRVSLAAAGGHlgSDYINANYVVGYEKERAYIASQGPLPDTV-GDFWRMAWEQTSRTIVMVAQVRENNRVKC
  .|   . ..||.|| ||   |.   |. ||..| || |. ||| .| |. |     ||||  |.    |... .. |... |.
dmnriphlycfdhsrvelapqdgk..ddfynaswvdgyskksayifaqapfndhteyvfwrmvserkpsmilvfgdidekqkrka
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 146-214 1.5e-11 38.7 In-house 216-287 (350) alignment 
Range on Protein: 146-214
Range on HMM: 216-287/350.0
EVVHLQMTTWPDHGSPRNPEAFLELHR------RFREAQRNARNSRSGPVglpIVHCSAGVGRSGTFICLDTVFE
.| .||.  |.| .   ||| .|.             |.    |.|| |.   .||||||||| ||.. || ...
vvyqlqvknWkDlslllnPesilqalevkndliddlfaeshldnarsspi...lvhCsaGvGrtGtlvtlDslls
subfamily_Sponge-PTP-2_pd Subfamily Sponge-PTP-2 12-166 5.7e-11 35.6 In-house 25-160 (169) alignment 
Range on Protein: 12-166
Range on HMM: 25-160/169.0
AVNARKQRYRDIVAYDHTRVSLAAAGGHLGSDYINAnyvvgyekerayiasqgplpdtvgdfwRMAWEQTSRTIVMVAQVRENNRVKCE--L--YWPAVD
..|  |.|    .|  |||| |     .||||||||                           || ||  .  ||.. .  . |    |       ||| 
tcnetknrpagplapshtrvklqrvmedlgsdyina...........................rmiwetnasvivvlgdtddknnfwpekedyqlhpavi

HSATYGPlMVYGRREEVLSP-NVTRRLFEI---HHQDEDRVQ-EVVHLQMTTWPDHGSPRNPEA
    |    .| | . | .  .    |||.    |. .| |  ..  |. .|||. | |..|  
lgewytd.slyvrtdkvhantsgveglfevsmvihsydddvteklsllhystwpqngvpqspvh
subfamily_Sponge-PTP2_pd Subfamily Sponge-PTP2 12-166 7.7e-11 35.1 In-house 24-159 (169) alignment 
Range on Protein: 12-166
Range on HMM: 24-159/169.0
AVNARKQRYRDIVAYDHTRVSLAAAGGHLGSDYINAnyvvgyekerayiasqgplpdtvgdfwRMAWEQTSRTIVMVAQVRENNRVKCE--L--YWPAVD
..|  |.|    .|  |||| |     .||||||||                           || ||  .  ||.. .  . |    |       ||| 
tcnetknrpagplapshtrvklqrvmedlgsdyina...........................rmiwetnasvivvlGdtddknnfwpekedyqlhpavi

HSATYGPlMVYGRREEVL-SPNVTRRLFEI---HHQDEDRVQE-VVHLQMTTWPDHGSPRNPEA
    |    .| | . |    .    |||.    |. .| | | .  |...|||. | |..|  
lGewytd.slyvrtdkvhpntsgveglfevslvihsydddvteqlsllhystwpqngvpqspvh
subfamily_CG42327_pd Subfamily CG42327 178-252 1.2e-10 35.5 In-house 239-310 (319) alignment 
Range on Protein: 178-252
Range on HMM: 239-310/319.0
QRNARNSRSGPVglpIVHCSAGVGRSGTFICLDTVFETLLAGRDPVEPLAIISRLRNCRNFMVQAVDQLDFIFRA
 |...... ||.   .|||| ||||.|. |  |  ...|   .  |.   ..| .|. |   |....| .||.. 
srsgtresqGPl...vvhcsdGvGrtGlviasdiairsleeskrsvdiPqlvssvrrdrasavltkeqyefiykv
subfamily_Sponge-PTP-4_pd Subfamily Sponge-PTP-4 25-161 1.6e-10 35.4 In-house 4-127 (130) alignment 
Range on Protein: 25-161
Range on HMM: 4-127/130.0
AYDHTRVSlaaagghlGSDYINANYVVGYEKERAYIASQGPLPDTVGDFWRMAWEQTSRTIVMVAQVRENNRvkcelYWPAVDHSATYGPLMVYGRREEV
 .. .|.         | .||||..|   .. . |. .| || ||  |||.|  |.    .|..  | |..      |||  .    |   ..    .  
efevsrlq........gntyinasfvGllgrtaeylltqhpladtsmdfwkmmleryvnvlvvlgsveeede.....ywpdsePlewyeediivtltdrd

LSPNVTRRLFEIHHQDEDRVQEVVHLQMTTWPDHGSP
 . |.    .||...  .  | .  .|.. ||  |. 
efknikasnleiesdlneshqaltmfqisnwpsdgtt
subfamily_Sponge-PTP3_pd Subfamily Sponge-PTP3 10-64 1.9e-10 34.7 In-house 44-95 (95) alignment 
Range on Protein: 10-64
Range on HMM: 44-95/95.0
RAAVNARKQRYRDIVAYDHTRVSLAAaggHLGSDYINANYVVGYEKERAYIASQG
 .  |  |.|. .|. || ||| |..   .  |||||| .| || .  .|||.||
sseanipknrflnifpydatrvvltt...krdsdyinacfvdgyarkncyiaaqg
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 193-252 4.5e-10 33.9 In-house 232-290 (297) alignment 
Range on Protein: 193-252
Range on HMM: 232-290/297.0
IVHCSAGVGRSGTFICLDTVFETLLAGRDPvEPLAIISRLRNCRNFMVQAVDQLDFIFRA
.|||||||||||  .  |.. . |  .| | .  ||.| ||. |  .||...| .... |
lvhcsaGvGrsGvvvlsdvilaklrkkrip.dvaailsilreqrarlvqtleqfellyda
0038934 (Phosphotyrosine protein) phosphatases II 148-251 1e-08 30.5 In-house 80-171 (194) alignment 
Range on Protein: 148-251
Range on HMM: 80-171/194.0
VHLQMTTWPDHGSP---RNPEAFLELHRRFREAQRNarnsrsgpvGLPIVHCSAGVGRSGTFICLdtvfetLLAGRDPVEPLAIISRLRNCRNFMVQAVD
..     .||.|..    .   ||.|  .| ... .         |.  ||| ||.||.||...        |  |    . . | ..| .|. ... .|
ieylklpfpddgtvPsleillrfldlvdeflnedpg.........gvvaVHCkaGlgRtGtlvaa......YLiyrlgmsaeeAialfrekRpgaipnqd

QLDFIFR
.|. ...
yleallk
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 11-54 1.3e-08 28.6 In-house 42-87 (440) alignment 
Range on Protein: 11-54
Range on HMM: 42-87/440.0
A--AVNARKQRYRDIVAYDHTRVSLAAAGGHLGSDYINANYVVGYE
|    |  |.|||.|.||||.|| |    |   |||||| |. | |
aslpnnkvknryrnilaydhsrvmleevkgvpdsdyinasyingie
subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 14-89 1.3e-08 28.8 In-house 37-117 (347) alignment 
Range on Protein: 14-89
Range on HMM: 37-117/347.0
NARKQRYRDIVAYDHTRVSLAAAGGHLG-----SDYINANYVVGYEKERAYIASQGPLPDTVGDFWRMAWEQTSRTIVMVA
.  |.| .|    | ||| |.    . .       |||| ..   . .. || .| |||||| |||.|        .| . 
slsknrskdvklidatrvvlspeksknsraddvetyinashikfdnaskeyiltqyplpdtvrdfwkmvsvtkvtqvvtif
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 145-217 1.8e-08 28.1 In-house 218-293 (349) alignment 
Range on Protein: 145-217
Range on HMM: 218-293/349.0
QEVVHLQMTTWPDHGSPRNPEAFLELH---RRFREaQRNARNSRSGP-VGLPIVHCSAGVGRSGTFICLDTVFETLL
 |.. ||.  |.| .   || ..|.       . . . .||.      .   .|||||| ||.|... || ... | 
yellqlqvknwldlslllnPisilqalevkndlid.dlfarlyldtdqlstllvhcsaGcGrtGvlvtldlllsile
subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 11-53 8.3e-08 26.1 In-house 36-77 (244) alignment 
Range on Protein: 11-53
Range on HMM: 36-77/244.0
AAVNARKQRYRDIVAYDHTRVSLAAAgGHLGSDYINANYVVGY
 ..|| |.|| .|. .|.||| |...  . |||||||||. | 
lsanatknryinilpfdetrvilsss.kkegsdyinanyiqgs
subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 58-163 1.4e-07 25.4 In-house 138-238 (244) alignment 
Range on Protein: 58-163
Range on HMM: 138-238/244.0
AYIASQGPLPDTVGDFWRMAWEQTSRTIVMVAQVRENNRvkcelYWPAVDHSATYGPLMVYGRREEVLSPNVTRRLFEIHHQDEDRVQEVVHLQMTTWPD
 || .| || ||  |||.|  |.    .|..  | |..      |||  .    |   .     .     |.    .||  . ..  | .  .|.. || 
eyiltqhpladtsmdfwkmmlerhvnvlvvlgsveeede.....ywpdseplewyeeditvtltdrdefknikasnleiesdmneshqaltmfqisnwps

HGSPRN
 |.  |
dgttpn
subfamily_Sponge-PTP7_pd Subfamily Sponge-PTP7 193-252 2.1e-06 22.0 In-house 1-59 (69) alignment 
Range on Protein: 193-252
Range on HMM: 1-59/69.0
IVHCSAGVGRSGTFICLDTVFeTLLAGRDPVEPLAIISRLRNCRNFMVQAVDQLDFIFRA
.||||.| ||.|||| .     . .     |. .  .  .| ||  ||   ..  ||  |
vvhcssGtGrtGtfiaimvem.arikseklvdifnnvqymrkcrpmmvmneneymfihda
subfamily_Sponge-PTP-7_pd Subfamily Sponge-PTP-7 193-250 3.3e-06 21.4 In-house 2-58 (69) alignment 
Range on Protein: 193-250
Range on HMM: 2-58/69.0
IVHCSAGVGRSGTFICLDTVFeTLLAGRDPVEPLAIISRLRNCRNFMVQAVDQLDFIF
.||||.| ||.||||..     . .     |. .  .  .| ||  ||    .  || 
vvhcssgtgrtgtfiaimvem.arikseklvdifnnvqymrkcrpmmvmneieyifih