Gene expression:
Classification
Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.
Protein sequence
Domains
Summary
Details
Domain | Domain Description | Range | Significance | Score | Source | Profile Range (length) | Alignment | ||
---|---|---|---|---|---|---|---|---|---|
subfamily_PTPN12_pd | Subfamily PTPN12 | 5-297 | 1.2e-128 | 423.1 | In-house | 2-286 (290) | alignment | ||
Range on Protein: 5-297
Range on HMM: 2-286/290.0
DQQDALEGFGAEFQRLRDMTAAYKAST--SREEGTTMHTKRKNRYKDIIPYDFNRVVLTTQRSEDedisGSDYINASSVEHGESQCRFIASQGPLPHTLD
..... | | .|||.|......|||.. |.|.|.......|||||||.|||..||.|.....|. |||||||......|.....||.|||||.|||
eekegeeefakefqklkklsekykaekvysteagekeenvkknrykDilPydksrvelskieeee....gsdYinanfikgvegkleyiaaqgPLpktld
DFWRMLWEKDVRIVVMACNIFENDRFKCAKYWPNLHEFDV-FDEFEVDNMAEDAIDQDFLVRTLKVTHKGASRIIYQYHYHAWPDHGVPARPGSVMRLIA
|||||.|||.|.||||||...|....||..|||. .| .. |.||||....|.|.|.|||.|||||.....||..||.||.||||||||... |...||.
dfWrmiweknveivvmaCrevelgkkkCerYWpeegeeelefgefevtleeekavdddflirtLkveaqkesrkvyqfhYtaWPDhgvPssaksllelie
AFRERQPsDQAAPLVIHCSAGVGRTghfllGTICAIDIVWSMLKQmGLDAPCFDIFQVVWFLRQHRPAMVQTEDQYVFVYKAILDLVQQVLASMDN
..||.| ...||||.||||||||| |||.|||.|...||. . ....|.|..|. ||..|.|.|||..||..||||...|||. |.....
lvrelqe.sedaPlvvhCsaGvGrt.....Gtiiaidyvrellka.ekipeeldvfdlvlelrkqraalvqtkeqyelvykavaelvqkeleiiee
|
|||||||||
0050432 | (Phosphotyrosine protein) phosphatases II | 5-291 | 7.7e-88 | 290.1 | In-house | 36-302 (308) | alignment | ||
Range on Protein: 5-291
Range on HMM: 36-302/308.0
DQQDALEGFGAEFQRLRDMTAaykaSTSREEGTTMHTKRKNRYKDIIPYDFNRVVLttqrsedeDiSGSDYINASSVEHG--ESQCRFIASQGPLPHTLD
.... | .. .||..|.... . ... . | |||||||.||| .||.| | .|||||||| | ....||| |||||.|..
ekaldlglleeefeellsvkp....lleysvallpenkdkNrykdilpydhsRVkl........d.egsdYInAsyvdgyssklprkfIatqgPlpntve
DFWRMLWEKDVRIVVMACNIFENDRFKCAKYWPNL--HEFDVFDEFEVDNMAEDAiDQDFLVRTLKVTH--KGASRIIYQYHYHAWPDHGVPARPGSVMR
|||||.|| .||..|| ....||.| |||.|||. ... ... | | .. |. ..|. ||||..|. .| ||.....||..||||||| | ....
dFwrmvweqnvrvIvmLtklvengrekcaqYwplelgggsleygkftvtllseev.lddytvrtleltnlgdgesrtvthfhytnWpdhgvPpspeilld
LIAAFRERQpsdQAAPLVIHCSAGVGRTghfllGTICAIDIVWSMLKQMgldaPCFDIFQVVWFLRQHRPAMVQTEDQYVFVYKAILDLVQQV
.. . |... . | |.||||||||| ||..|.|.....|.. ..|.|..| .||..|| ||||..||.|.|.|.|.... .
flelvrksl...pggpivVHCsaGvGRt.....Gtfialdllleqleke....ggvdvfeavkklReqRpgmvqtpeqylflyralleylklk
|
|||||||||
0046845 | (Phosphotyrosine protein) phosphatases II | 13-290 | 5.2e-86 | 283.8 | In-house | 2-276 (284) | alignment | ||
Range on Protein: 13-290
Range on HMM: 2-276/284.0
FGAEFQRLRDMTAAYKasTSREEGTTMHTKRKNRYKDIIPYDFNRVVLTtqrSEDEDISGSDYINASSVEHG-----ESQCRFIASQGPLPHTLDDFWRM
. .||..|. .| . |.. . . . |||||||.||| .||.|. |.|.|...||||||| |. ....||| |||||.|..|||||
leeefeellsltvkll..lslsvallpenlsknRykdilpydhsRVklk...sldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrm
LWEKDVRIVVMACNIFENDRFKCAKYWPNLHEFDVFDEFEVDNMAEDAiDQDFLVRTLKVTH---KGASRIIYQYHYHAWPDHGVPARPGSVMRLIAAFR
.||..||..|| ....||.| |||.|||. .|. ....| | .. |. ..|. ||||..|. .| ||.....||..|||||||. | ...... . |
vweqnvrvIVmltelvengrekcaqYwplegevltygdftvtllseev.kddytvrtleltnlgytgesrtvthfhytswpdhgvppspedlleflrlvr
ERQPS-DQAAPLVIHCSAGVGRTghfllGTICAIDIVWSMLKQMGLDaPCFDIFQVVWFLRQHRPAMVQTEDQYVFVYKAILDLVQQ
| ... .. | |.||||||||| ||..|.|.....|.. ||. ..|....| .||..|| ||||..||.|||.|.|....
ellenlpgggpivVHCsaGvgRt.....Gtfialdllleqlekegll.lgvdvleavkrlreqRpgmvqtleqyrfvyealleylkl
|
|||||||||
0051299 | (Phosphotyrosine protein) phosphatases II | 7-288 | 5.5e-86 | 283.9 | In-house | 19-286 (288) | alignment | ||
Range on Protein: 7-288
Range on HMM: 19-286/288.0
QDALEGFGAEFQRLRDMTAAykasTSREEGTTMHTKRKNRYKDIIPYDFNRVVLTTQRSededISGSDYINASSVEHGESQCRFIASQGPLPHTLDDFWR
.. | |. .||..|..... .. . . . ||||.||.||| .||.|.. . ..|||||||| .. .....||| |||||.|..||||
angltglleefeellsllpd....ltlsaallpenleknRysdilpydhsRVkLsvldg....vegsdYinAsyidgynlkrkfIatqgPlpntvedFWr
MLWEKDVRIVVMACNIFENDRFKCAKYWPNlHEFDVFDEFEVDNMAEDAiDQDFLVRTLKVT------HKGASRIIYQYHYHAWPDHGVPARPGSVMRLI
|.||..||..|| ....|..| |||.|||. ... ..... | .. |. ..|. ||||.|| .| ||.....||..||||||| | ......
mvweqnvrvIvmltklvelgrekcaqYwpl.ggsltygditvtllseev.lddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpdspellldfl
AAFRERQPsDQAAPLVIHCSAGVGRTGhfllgTICAIDIVWSMLKQMgldaPCFDIFQVVWFLRQHRPAMVQTEDQYVFVYKAILDLV
..|. .. .. | |.|||||||||| |..|.|.....|.. ..|....| .||..|| ||||..||.|||.|.|...
rlvrkala.sgggpvvVHCsaGvgRtg.....tfialdllleqleke....ggvdvleavkrlreqRpgmvqtpeqyrfvyealleyl
|
|||||||||
subfamily_PTPRD_pd | Subfamily PTPRD | 30-297 | 1.5e-85 | 283.0 | In-house | 37-290 (564) | alignment | ||
Range on Protein: 30-297
Range on HMM: 37-290/564.0
STSREEGTTMHTKRKNRYKDIIPYDFNRVVLTTQRSEdediSGSDYINASSVEHGESQCRFIASQGPLPHTLDDFWRMLWEKDVRIVVMACNIFENDRFK
... |. . . |.||||..|..|| .||||.. . . .|||||||| .. ... .||.||||..|..|||||.||......|| .. |... |
qftweaankpaNkaKNRyanivaYdhsRVvLskvegd....egsDYINAsfidgyrkrkayIAtqgPlaetiedFWRmvweqnsstiVmltkleEkgkvk
CAKYWPNLHeFDVFDEFEVDNMAEDAIdQDFLVRTLKVTH--KGASRIIYQYHYHAWPDHGVPARPGSVMRLIAAFRERQpSDQAAPLVIHCSAGVGRTG
|.||||. . ..|..|. ..| . .|. .||.|... . || . |.|. .||||||| . |...|| |. . ...| |.|.||||||||||
chkYWPekg.tetygeltVtleeeeel.adyeirtfklkkkkssesreVrqFhFtsWPdhgvpesatslLdlirkvraln.epdagPivVhCSaGVGRTG
HFllgtiCAIDIvwsMLKQMGLdAPCFDIFQVVWFLRQHRPAMVQTEDQYVFVYKAILDLVQQVLASMDN
| ..||. ||... ||.|.|. ||..|.||||||.||.|...|||. .. ...
tf.....ivida...mlerike.ektvDiyqyvkalrkqRnamVqteeQYiFiheailealacgnteves
|
|||||||||
0040438 | (Phosphotyrosine protein) phosphatases II | 11-293 | 6.4e-84 | 277.2 | In-house | 18-281 (317) | alignment | ||
Range on Protein: 11-293
Range on HMM: 18-281/317.0
EGFGAEFQRLRDMtaayKAStSREEGTTMHTKRKNRYKDIIPYDFNRVVLTTqrseDEDISGSDYINASSVEHGESQCRFIASQGPLPHTLDDFWRMLWE
.. ||..|... | . ..... | ||||.||.|||..||.|. .. . .||||||| |. . . .||| |||||.|..|||||.||
talleefedllsl....kld.tysvaelpenkdknrypdilpydhsRVkLsp....lggdldsdYInAsyvdgpnlkrkfIatqgPlpntvedFwrmvwe
KDVRIVVMACNIFENDRFKCAKYWPNlHEFDVFDEFEVDNMAEDAiDQDFLVRTLKVTH--KGASRIIYQYHYHAWPDHGVPARPGSVMRLIAAFRERQP
.|...|| .. .|..| |||.|||. |. ....| | .. |. .... .|||.|.. .. ||.....||..||||||| | .. ... | || ..
qgvtvivmLteleelgrekcaqYwpl.getltygdftvtllseee.lagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfleavreale
sDQAAPLVIHCSAGVGRTghfllGTICAIDIVWSMLKQMGldapCFDIFQVVWFLRQHRPAMVQTEDQYVFVYKAILDLVQQVLA
|. |...||||||||| ||..|.......|.. | ..|....| .||..|| .|||..||.|.|.|.|.... .|
.dpggpvlVHCsaGvgRt.....Gtfiaaylmleqlekeg....gvdveeavkelreqRpgavqtpeqyrflydalleylkrklt
|
|||||||||
0036941 | (Phosphotyrosine protein) phosphatases II | 4-289 | 1.7e-83 | 275.6 | In-house | 6-278 (297) | alignment | ||
Range on Protein: 4-289
Range on HMM: 6-278/297.0
SDQQDALEGFGAEFQRLRDMTAaykaSTSREEGTTMHTKRKNRYKDIIPYDFNRVVLttqrsedEDiSGSDYINASSVEHGESQCRFIASQGPLPHTLDD
..... | .. ||..| .. . . |.. . .. |||||||.|||..||.| .| .|||||||| |. . . .||| |||||.|..|
lekllflalllkefeellplll....lgslsvallpenleknRykdilpydhtRVkl.......dd.egsdYinAsyvdgydlkrkfIatqgPlpntved
FWRMLWEKDVRIVVMACNIFENDRFKCAKYWPNL-HEFDVFDEFEVDNMAEDAI-DQDFLVRTLKVTH--KGASRIIYQYHYHAWPDHGVPARPGSVMRL
||||.|| .|...|| .. .|..| |||.|||. |. ....| | .. .. . ..|. .|||.||. .| ||.....||. ||||||| | |....
FWrmvweqnvtvIvmltelvelgrekcaqywpleegesltygdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldf
IAAFRERQPSD-QAAPLVIHCSAGVGRTGhfllgTICAIDIVWSMLKQMgLDAPCFDIFQVVWFLRQHRPAMVQTEDQYVFVYKAILDLVQ
| ..|.... . | ..||||||||.| |..|.|.....|.. | ...||...| .||..|| .|||..||.|.| |.|.|..
ielvrkvlkllpsggpvlVHCsaGvgRsg.....tfiaadlmlqqledk.lkeggvdileavkklReqRpgavqtleqyrflyeallellk
|
|||||||||
0039614 | (Phosphotyrosine protein) phosphatases II | 6-290 | 6.3e-83 | 273.9 | In-house | 27-291 (297) | alignment | ||
Range on Protein: 6-290
Range on HMM: 27-291/297.0
QQDALEGFGAEFQRLRDMTAaykastSREEGTTMHTKRKNRYKDIIPYDFNRVVLTTQRSEDEdisGSDYINASSVEHGES-QCRFIASQGPLPHTLDDF
... .. .||..| ... ..... | |||||||.|||..||.|.. .. |. .||||||| |. . . .|||.|||||.|..||
kansktllllefeellslkp......dysiallpenkdknrykdilpydhsrvklkpedgvdl...dsdYinAsyvdgydlltrkfIatqgPlpetvedF
WRMLWEKDVRIVVMACNIFENDRfKCAKYWPNLHEfdVFDEFEVDNMAEDAiDQDFLVRTLKVTHKGASRIIYQYHYHAWPDHGVPARPGSVMRLIAAFR
|||.|| .|...|| .. .|..| |||.|||. . ....| | .. .. .... ||||.||..| ||......|. ||||||| . ...... . |
wrmvweqgvtvivmLtklvelgr.kcaqywpeegg..tygdftvtllkveh.ldgytvrtlevtnngesrtvthfqytgwpdhgvppslellleflelvr
ERQPSD-QAAPLVIHCSAGVGRTghfllGTICAIDIVWSMLKQMgldaPCFDIFQVVWFLRQHRPAMVQTEDQYVFVYKAILDLVQQ
|.. .. . | ..||||||||| ||..|.......|. ..|....| .||..|| .|||..||.|.|.|.|.|...
ealaelpkggpvlVHCsaGvgRt.....Gtfiaaylmleqleke....ggvdvleavkelreqRpgavqtpsqyrflydallellkr
|
|||||||||
0047943 | (Phosphotyrosine protein) phosphatases II | 4-287 | 1.1e-82 | 272.9 | In-house | 5-271 (273) | alignment | ||
Range on Protein: 4-287
Range on HMM: 5-271/273.0
SDQQDALEGFGAEFQRLRDMTAaykaSTSREEGTTMHTKRKNRYKDIIPYDFNRVVLttqrsedeDISGSDYINASSVEHGESQCRFIASQGPLPHTLDD
.... | .. .||..|.... . ... . . | |||||||.||| .||.| . .|||||||| |. ... .||| |||||.|..|
lekllgltllleefelllslkp....lltysvallpenkdknrykdilpydhsrvkl........gdggsdyinAsyvdgynlkrkfiatqgPlpntved
FWRMLWEKDVRIVVMACNIFENDRFKCAKYWPNLHE--FDVFDEFEVDNMAEDAiDQDFLVRTLKVTH--KGASRIIYQYHYHAWPDHGVPARPGSVMRL
||||.||..||..|| ....|..| |||.|||. . . ....| | .. |. ..|. ||||..|. | ||.....||. |||||||. . |....
fwrmvweqnvrviVmLtelvelgrekcaqYwpleggelsltygkftvtllseet.kddytvrtleltnlgtgesrtvthfhytgwpdhgvppslesllef
IAAFRERQPSD-QAAPLVIHCSAGVGRTghfllGTICAIDIVWSMLKQMGldapCFDIFQVVWFLRQHRPAMVQTEDQYVFVYKAILDL
| . |. . .. . | |.||||||||| ||..|.|.....|. | ..|....| .||..|| ||||..||.|.|.|.|..
ielvrkalealpsngpvvVHCsaGvgRt.....gtfialdllldqlekeg....gvdvleavkllrsqRpgmvqtpeqyrflyealley
|
|||||||||
DSPc_SM00195 | 15-288 | 5.8e-82 | 270.3 | In-house | 4-262 (263) | alignment | |||
Range on Protein: 15-288
Range on HMM: 4-262/263.0
AEFQRLRDMTAAYkastSREEGTTMHTKRKNRYKDIIPYDFNRVVLTTQRSEdediSGSDYINASSVEHGESQCRFIASQGPLPHTLDDFWRMLWEKDVR
.||..|...| . .|. . |.|||||.|.||| .|| |... .. .|||||||. .. ... ..|| |||||.|..||||| ||..|.
eefekleestspk....etteaekkknksknRyknilpydhtrVklkkeekk....egsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvk
IVVMACNIFENDRFKCAKYWPNL-HEFDVFDEFEVDNMAEDAIDQDFLVRTLKVTHKG--ASRIIYQYHYHAWPDHGVPARPGSVMRLIAAFRERQPSDq
|.|| .. .||.. ||..|||. .. .|....| .. .. .... .|||..|..| .| ..||.|..||||||| . ||..|. |..... .
iivmlteeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkksksts.
AAPLVIHCSAGVGRTGhfllgTICAIDIVWSMLKQMGLdapcFDIFQVVWFLRQHRPAMVQTEDQYVFVYKAILDLV
.|.|.|||||||||| |...|||..| |.. .|||..| ||..|| ||||..|| |.|.|||...
sgpivVhCsaGvgRtg.....tfvtidiilskleeekk....vdifeivkelRkqRpgmvqtleqYlfiyeaileyi
|
|||||||||
PTPc_SM00194 | 15-288 | 5.8e-82 | 270.3 | In-house | 4-262 (263) | alignment | |||
Range on Protein: 15-288
Range on HMM: 4-262/263.0
AEFQRLRDMTAAYkastSREEGTTMHTKRKNRYKDIIPYDFNRVVLTTQRSEdediSGSDYINASSVEHGESQCRFIASQGPLPHTLDDFWRMLWEKDVR
.||..|...| . .|. . |.|||||.|.||| .|| |... .. .|||||||. .. ... ..|| |||||.|..||||| ||..|.
eefekleestspk....etteaekkknksknRyknilpydhtrVklkkeekk....egsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvk
IVVMACNIFENDRFKCAKYWPNL-HEFDVFDEFEVDNMAEDAIDQDFLVRTLKVTHKG--ASRIIYQYHYHAWPDHGVPARPGSVMRLIAAFRERQPSDq
|.|| .. .||.. ||..|||. .. .|....| .. .. .... .|||..|..| .| ..||.|..||||||| . ||..|. |..... .
iivmlteeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkksksts.
AAPLVIHCSAGVGRTGhfllgTICAIDIVWSMLKQMGLdapcFDIFQVVWFLRQHRPAMVQTEDQYVFVYKAILDLV
.|.|.|||||||||| |...|||..| |.. .|||..| ||..|| ||||..|| |.|.|||...
sgpivVhCsaGvgRtg.....tfvtidiilskleeekk....vdifeivkelRkqRpgmvqtleqYlfiyeaileyi
|
|||||||||
0045450 | (Phosphotyrosine protein) phosphatases II | 4-288 | 1.2e-80 | 266.9 | In-house | 20-304 (307) | alignment | ||
Range on Protein: 4-288
Range on HMM: 20-304/307.0
SDQQDALEGFGAEFQRLRDMTAAYkaSTSREEGTTMHTKRKNRYKDIIPYDFNRVVLTTQRSEdedISGSDYINASSV--------EHGESQCRFIASQG
...| |.|. .||..|...| . . ..... . | |||||||.||| .||.|.. .. ...||||||| | . .. .||| ||
lllldfltgllkefekllsvtvfl..lgeysiallpenkdknrykdilpydhtRVklssldgs...ledsdYiNAsyvrvpllllldgydlkrkfIatqg
PLPHTLDDFWRMLWEKDVRIVVMACNIFENDRFKCAKYWPNLHEFDVFDEFEVDNMAEDAiDQDFLVRTLKVT---HKGASRIIYQYHYHAWPDHGVPAR
|||.|..||||||||..|...|| .. .|..| |||.|||. |. ....| | .. |. .... ||||.|| .| ||.....||..|||||||
PlpetvedFwrmlweqgvtvivmltelvelgrekcaqywPdegeeltygnftvtllseeh.ldgytvrtlevtdldgtgesrtvthfhytgwpdhgvpps
PGSVMRLIAAFRERQPSD-QAAPLVIHCSAGVGRTGhfllgTICAIDIVWSMLKQMGLDAPcFDIFQVVWFLRQHRPAMVQTEDQYVFVYKAILDLV
. .. ..| . |. . .. . | ..|||||||||| |..|.......|.. | .|....| .||..|| .||...||.|.|.|.|.|.
feelldfieevrkaleelpkggpvlVHCsaGvgRtG.....tfiaaylmlrqlekegtlld.vdlleavkllreqRpgavqnpeqyrflyeallell
|
|||||||||
subfamily_PTPN6_pd | Subfamily PTPN6 | 3-290 | 1.9e-80 | 265.2 | In-house | 18-299 (306) | alignment | ||
Range on Protein: 3-290
Range on HMM: 18-299/306.0
KSDQQDALEGFGAEFQRLRDMTaaYKASTSREEGTTMHTKRKNRYKDIIPYDFNRVVLTtqrseDEDISGSDYINASSVE--HGESQCRFIASQGPLPHT
|.... . .|| ||..|. . | ||.||. .. |.||||| |.|.| .||.|. .....|||||||. .. .|....||.|| |..|
keeeslekagfeeefeelqqee..akkllsrkegakpenkeknryknilPfDhtrvilk.....epsvpgsdyinanyikkevkgsdksyiatqgclett
LDDFWRMLWEKDVRIVVMACNIFENDRFKCAKYWPNLHEFDVFDEFEVDNMAEdAIDQDFLVRTLKVTH---KGASRIIYQYHYHAWPDHGVPARPGSVM
. |||||.|... |..||. . | . |||.|||. .| . . . .| |..| .|. .|.|.|.. |. .| ..|||...|||||||. || |.
vsdFWrmvwqensrvivmttkevErgkekCarYWPdeeekeeyGkisvtnvse.ksladYilRelsvskkkkkkeerevfqyhfksWPdhgvpkdpgavL
RLIAAFRERQPSDQ---AAPLVIHCSAGVGRTGHFLlgticAIDIVWSMLKQMGLDAPcFDIFQVVWFLRQHRPAMVQTEDQYVFVYKAILDLVQQ
.. ...| . . | |.|.|||||.|||| |. |||. ..... ||||. .|| ..| .|..| .||||.|| |||||| ...
dfledvnrkqeeleeaeagpivvhCsaGiGRtGtfi.....viDillkliekkgldad.idiqklvksvreqrsglvqteqqykfvykaikkyiet
|
|||||||||
0043336 | (Phosphotyrosine protein) phosphatases II | 10-287 | 1.9e-80 | 265.6 | In-house | 19-276 (278) | alignment | ||
Range on Protein: 10-287
Range on HMM: 19-276/278.0
LEGFGAEFQRLRDMTAaykasTSREEGTTMHTKRKNRYKDIIPYDFNRVVLTTqrseDEDISGSDYINASSVEHGESQCRFIASQGPLPHTLDDFWRMLW
.. .||..|.... ... . .. | |||||||.|||..||.|. .. .||||||| |. . . .|||.|||||.|..|||||.|
ktllllefeellsfkl.....dtysiallpenkdknrykdilpydhsrvklsl....lggdldsdYinAsyvdgynvprkfiatqgPlpetvedFwrmvw
EKDVRIVVMACNIFENDRFKCAKYWPnlHEFDVFDEFEVDNMAEDAiDQDFLVRTLKVT--HKGASRIIYQYHYHAWPDHGVPARPGSVMRLIAAFRERQ
| .|...|| .. .|..| |||.||| .. ....| | .. |. ..|. ||||.|| .| ||....|||..||||||| . ...... |.||..
elgvttivmLtelvelgrvkcaqYwp..ggsltygdftvtllkeeh.lddytvrtlevtnlgdgesrtvthyhylgwpdhgvpeslsllldflkavreal
PsDQAAPLVIHCSAGVGRTghfllGTICAIDIVWSMLKQMGldapCFDIFQVVWFLRQHRPAMVQTEDQYVFVYKAILDL
. |. |...||||||||| ||..|.......|. | ..|....| .||..|| .|||..||.|.|.|.|..
e.dsngpvlVHCsaGvgRT.....Gtfialyllleqlekeg....gvdleeavkelreqRpgavqtpsqyrflyealley
|
|||||||||
subfamily_Anemone-PTP-6_pd | Subfamily Anemone-PTP-6 | 13-297 | 9.5e-79 | 259.7 | In-house | 22-289 (318) | alignment | ||
Range on Protein: 13-297
Range on HMM: 22-289/318.0
FGAEFQRLRDMTAAYKASTSreegTTMHTKRKNRYKDIIPYDFNRVVLTTQRSEdediSGSDYINASSVEHGESQCRFIASQGPLPHTLDDFWRMLWEKD
. .|..|| .. . | .. |.|||| .|..|| || |... .| |||||||. .. ... .||.|.|||.|..|||||.||..
lseeyerlsrseetvtslks....lepvnkaknryanilaydhtrvkLqmlege....egsDyinanyidGyrrkkayiaaqaPlpetieDfWrmvWeqn
VRIVVMACNIFENDRFKCAKYWPNLHEfDVFDEFEVDnMAEDAIDQDFLVRTLKVTHKG--ASRIIYQYHYHAWPDHGVPARPGSVMRLIAAFRERQPSD
...|| .. |. . |...|||. ... |. . |. .|...|..|||... .||.. |||| .|||.|||. ..|.. |. .. | .
savivmltqeeergkakvhryWPskgs.rsygklvve.lkeevelsdyvlrefkvtrteeeesrqvrqyhytsWpdegvpesgaslldlvrqvskaqqks
QAAPLVIHCSAGVGRTGHFllgtiCAIDIVWSMLKQMGldapCFDIFQVVWFLRQHRPAMVQTEDQYVFVYKAILDLVQQVLASMDN
.| |.|.|||||||||| | .|.||. .|. . |.||.| ||..|..||||||||.|.|...|. .. . .|
gagpivvhCsaGvGrtGvf.....iavdillerikaea....lvDvfqtvkqlreqrnlmvqtedqyefiydvllealasgdtevda
|
|||||||||
subfamily_PTPRB_pd | Subfamily PTPRB | 6-290 | 3.2e-78 | 257.7 | In-house | 20-287 (293) | alignment | ||
Range on Protein: 6-290
Range on HMM: 20-287/293.0
QQDALEGFGAEFQRLRDMTAAYKASTSReegtTMHTKRKNRYKDIIPYDFNRVVLTTQrsedEDISGSDYINASSVEHGESQCRFIASQGPLPHTLDDFW
..|. .| |...|... . .... .. . ||||..|.||| .|| |.. .| ||||||||. .. .|. |||.|||||.|.||||
kadsdlrfseeyeelkavgkdqavkaae....lavnraknrytnilpydhsrvkLaal....kdesgsDYinanyipgynsprefiatqGPlpetvddfW
RMLWEKDVRIVVMACNIFENDRFKCAKYWPNLHEFDVFDEFEVDNMAEDAIdQDFLVRTLKVTHKGASRIIYQYHYHAWPDHGVPARPGSVMRLIAAFRE
||.||| ..|.|| ...|. . || .|||. .| .. . .|. .||. .|. .|.||.... ..| . |||. .||||||| .. ...... ..||
rmvwekkssiivmltqlvekgkvkCeeYWPadeepvlyGdikvtlvaeeel.edwvirelkiekekeerkvrqyhftsWpdhgvPektktlldfvrtvre
RQ-PSDQAAPLVIHCSAGVGRTGHFLlgticAIDIVWSMLKQmgldAPCFDIFQVVWFLRQHRPAMVQTEDQYVFVYKAILDLVQQ
.. . ...|.|.|||||||||| |. |.| . . ... . ||| .| ||..| .||||.||.|.....|||...
aiektaskrPivvhCsaGvGRtGtfi.....aldrllqaiee....edyvdifgivaelReeRnllvqtekqYifihqcvldllrk
|
|||||||||
Y_phosphatase | Protein-tyrosine phosphatase | 42-285 | 3.1e-77 | 254.5 | Pfam-A | 2-234 (235) | alignment | ||
Range on Protein: 42-285
Range on HMM: 2-234/235.0
KRKNRYKDIIPYDFNRVVLttqrseDEDISGSDYINASSVEHGESQCRFIASQGPLPHTLDDFWRMLWEKDVRIVVMACNIFENDRFKCAKYWP-NLHEF
|.|||||||.|||..|| | ... . ||||||. |. ... .|||.||||..|..|||||.|...|...|| .. |..| |||.||| . .|.
kkknRykdilpydktrvkl......kgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeees
DVFDEFEVDNM-AEDAIDQDFLVRTLKVTHKGASR---IIYQYHYHAWPDHGVPARPGSVMRLIAAFRERQpSDQAAPLVIHCSAGVGRTGhfllgTICA
.....| .. | ...... .|.|....|.... ...|.||..|||||||. | |...|| ...... ... .|.|.|||||||||| |..|
ltygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkveksk.eaksgpvvVhCsaGvgRtg.....tfva
IDIVWSMLKQMGLdapcFDIFQVVWFLRQHRPAMVQTEDQYVFVYKAIL
.||....|.. . .|..|.| ||..|| |||...||.|.|||||
ldilleqleaeee....vdvlqivkelRkqRpgmvqsleqYiflykail
|
|||||||||
Y_phosphatase | Protein-tyrosine phosphatase | 42-285 | 3.1e-77 | 254.5 | In-house | 2-234 (235) | alignment | ||
Range on Protein: 42-285
Range on HMM: 2-234/235.0
KRKNRYKDIIPYDFNRVVLttqrseDEDISGSDYINASSVEHGESQCRFIASQGPLPHTLDDFWRMLWEKDVRIVVMACNIFENDRFKCAKYWP-NLHEF
|.|||||||.|||..|| | ... . ||||||. |. ... .|||.||||..|..|||||.|...|...|| .. |..| |||.||| . .|.
kkknRykdilpydktrvkl......kgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeees
DVFDEFEVDNM-AEDAIDQDFLVRTLKVTHKGASR---IIYQYHYHAWPDHGVPARPGSVMRLIAAFRERQpSDQAAPLVIHCSAGVGRTGhfllgTICA
.....| .. | ...... .|.|....|.... ...|.||..|||||||. | |...|| ...... ... .|.|.|||||||||| |..|
ltygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkveksk.eaksgpvvVhCsaGvgRtg.....tfva
IDIVWSMLKQMGLdapcFDIFQVVWFLRQHRPAMVQTEDQYVFVYKAIL
.||....|.. . .|..|.| ||..|| |||...||.|.|||||
ldilleqleaeee....vdvlqivkelRkqRpgmvqsleqYiflykail
|
|||||||||
0045098 | (Phosphotyrosine protein) phosphatases II | 33-290 | 4.4e-74 | 244.6 | In-house | 25-274 (278) | alignment | ||
Range on Protein: 33-290
Range on HMM: 25-274/278.0
REEGTTMHTKRKNRYKDIIPYDFNRVVlttqrsededisgsDYINASSVEHGesQCRFIASQGPLPHTLDDFWRMLWEKDVRIVVMACNIFENDRFKCAK
... . |||||||.|||..||. |||||| .. . .||| |||||.|..|||||||| .....||... .|..| |||.
itpalylgnldknRykdilpydhsrVk..............dYINAsyidgy..pkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrekcaq
YWPNlHEFDVFDEFEVDNMAEDAIdQDFLVRTLKVT------HKGASRIIYQYHYHAWPDHGVPARP--GSVMRLIAAFRERQP------------SDQA
|||. ... ....|.| .. |. . .|. .|||.|| . . || ....||. ||||||| | |. .|. ||.. |.
ywpe.ggsltygdftvtllseevl.ddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsg
APLVIHCSAGVGRTGHFllgtiCAIDIVWSMLkqmglDaPCFDIFQVVWFLRQHRPA-MVQTEDQYVFVYKAILDLVQQ
| ..|||||||||| . .|.... ..| . . .|....| .||..|| .||...||.|.|...|.|...
gpvlVHCsaGvgRtGtl.....vaaylmlell.....e.ggvdlleavkelrsqRpglavqnleqyrflyefllelllr
|
|||||||||
0040439 | (Phosphotyrosine protein) phosphatases II | 36-288 | 7.4e-74 | 243.8 | In-house | 6-246 (249) | alignment | ||
Range on Protein: 36-288
Range on HMM: 6-246/249.0
GTTMHTKRKNRYKDIIPYDFNRVVLTTQRSededISGSDYINASSVEHGESQCRFIASQGPLPHTLDDFWRMLWEKDVRIVVMACNIFENDRFKCAKYWP
. . | ||||.||.|||..||.|. .. .||||||| .. .. |||| |||||.|..|||||||| .....||... .|..| |||.|||
allpenkdknrypdilpydhsrvklsilpg....lflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywp
NlHEFDVFDEFEVDNMAEDAiDQDFLVRTLKVT--HKGASRIIYQYHYHAWPDHGVPARPGSVMRLIAAFRERQPSD-QAAPLVIHCSAGVGRTghfllG
. .. ....| | .. .. .|. ||||..| .| || .....|. ||||||| . .....| | |. . .. . |...||||||||| |
l.ggsleygdftvtllsvev.kddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRt.....G
TICAIDIVWSMLKQMgldaPCFDIFQVVWFLRQHRPAMVQTEDQYVFVYKAILDLV
|..|.......|. ..|....| .||..|| .||...||.|.|.|.|.|.
tfiaaylmleqleke....lgvdleeavkllrsqRpgavqnpeqyrflyeallell
|
|||||||||
subfamily_Anemone-PTP-2_pd | Subfamily Anemone-PTP-2 | 5-289 | 1.7e-73 | 242.5 | In-house | 21-291 (298) | alignment | ||
Range on Protein: 5-289
Range on HMM: 21-291/298.0
DQQDALEGFGAEFQRLRDMTAAYKAStSREEGTTMHTKRKNRYKDIIPYDFNRVVLTTQRsEDEDisgSDYINASSVEHGESQCRFIASQGPLPHTLDDF
... | |. .|||||. .. .. . | . . . |.|||| |||..|. ||||... .||. ||||||| .. . . |||.|.||..|. ||
kkkkkltgyalefqrlnsvsseieee.ekevarkpenkkkNRyadiialdssRvvLeked.adee...sdYiNAsflhaykgrnafiatqaPltetvedF
WRMLWEKDVRIVVMACNIFENDRFKCAKYWPNlHEFDVFDEFEVDNMAEDAiDQDFLVRTLKVTHKG--ASRIIYQYHYHAWPDHGVPARPGSVMRLIAA
|||..|.|. .|| |. | |. |. ||||. .. . ..|..|. .... |. ||.|||..| .| . | |. |||.|||. ||. |..
WrmvteedigtiVmltnleeldktkyhkywPd.egketygeitvsllskee.fadlivrklkvskkkeekerevrqlhftsWpdkgvpenatsvldllrk
FRERQPSDQAAPLVIHCSAGVGRTGHFllgtiCAIDivwSMLKQMGLDApCFDIFQVVWFLRQHRPAMVQTEDQYVFVYKAILDLVQ
| | .|....|||||||.| | .||| |.| .. . |.|||| ||..||..||||.||||.|.|.|. ..
vrasqqqagnkpvivqCsaGvgRsGtf.....iaid...svlervkkeq.vvDvfqvvkvlRkkrpgavqteeqYvfiyeavleald
|
|||||||||
0042113 | (Phosphotyrosine protein) phosphatases II | 40-288 | 2.5e-73 | 241.8 | In-house | 8-243 (245) | alignment | ||
Range on Protein: 40-288
Range on HMM: 8-243/245.0
HTKRKNRYKDIIPYDFNRVVLTTqrseDEDISGSDYINASSVEHGESQCRFIASQGPLPHTLDDFWRMLWEKDVRIVVMACNIFENDRFKCAKYWPNlHE
. | ||||.||.|||..||.|. |. .||||||| | . .|||.|||||.|..|||||||| .....|| .. .|..| |||.|||. .|
enkdknrysdilpydhtrvklsp....dggdldsdyinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywpl.ge
FDVFDEFEVDNMAEDAiDQDFLVRTLKVT--HKGASRIIYQYHYHAWPDHGVPARPGSVMRLIAAFRERQPSDQAAPLVIHCSAGVGRTghfllGTICAI
. ....| | .. |. ..|. ||||.|| .. || ...|||. ||||||| . .. ... . |. . .|. |...||||||||| ||..|.
sltygdftvtllseeh.lddytvrtlevtnlgddesrevihyhylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRt.....Gtfiaa
DIVWSMLKQMGldapCFDIFQVVWFLRQHRPAMVQTEDQYVFVYKAILDLV
......|. . .......| .||..|| .|||..||.|.|.|.|.|.
ylmleqlekel....gvsleeavkelrsqRpgavqtpsqyrflyeallell
|
|||||||||
subfamily_Urchin-PTPRB-like_pd | Subfamily Urchin-PTPRB-like | 8-290 | 1.7e-71 | 235.6 | In-house | 18-281 (288) | alignment | ||
Range on Protein: 8-290
Range on HMM: 18-281/288.0
DALEGFGAEFQRLrdmtAAYKASTSREEGTTMHTKRKNRYKDIIPYDFNRVVLTTQrsedEDISGSDYINASSVEHGESQCRFIASQGPLPHTLDDFWRM
.. .|| |.. | || . . | . | . ..||||..|.|||..|| |. |. .|.|||||| .. ... ..||.||||..|..|||..
rnrtgfseeynsL....aalektksvtagrlavnakknRyrnilpyDekrvklkkl....eeeagaDYinasyidgekkkkkyiatqgPladtvndfWel
LWEKDVRIVVMACNIFENDRFKCAKYWPNLHEFDVFDEFEVDnMAEDAIDQDFLVRTLKVTHKGASRIIYQYHYHAWPDHGVPARPGSVMRLIAAFRERQ
.|... .|| .. |... || .|||. .. . ...| . |. .||..|.| . .|. . | ||.| ||||||||. .. |. .
vyenktstivmltelveggktkCeeYWPdadkpknyGsvtvt.lveskeledfvlrklllekkkteleitqyqylaWpdhgvPeskapllellrqvkvan
PSDqAAPLVIHCSAGVGRTGHFLlgticAIDIVWSMLKQmgldAPCFDIFQVVWFLRQHRPAMVQTEDQYVFVYKAILDLVQQ
..| . |...|||||||||| |. |.| . .... |.. .| ||..|. .|||. ||.|.|...|.|...
qad.tgpiivhCsaGvGrtgtFi.....aldalidavee....edyiDvagtvaklRkqRallvqtlkqYefiyevllsliee
|
|||||||||
0037934 | (Phosphotyrosine protein) phosphatases II | 40-287 | 4.4e-70 | 231.3 | In-house | 9-241 (243) | alignment | ||
Range on Protein: 40-287
Range on HMM: 9-241/243.0
HTKRKNRYKDIIPYDFNRVVLttqrsedediSGSDYINASSVEHGEsqcRFIASQGPLPHTLDD----FWRMLWEKDVRIVVMACNIFENDRFKCAKYWP
. ||||.||.|||..||.| .|||||||. .. . |.||.|||||.|..| ||||||| .....|| .. .|..|.|||.|||
enlsknrysdilpydhsrvkl..........egsdyinanliyvtp...rliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywp
nlHEFdVFDEFEVDNMAEDAIdQDFLVRTLKVTH---KGASRIIYQYHYHAWPDHGVPARPGSVMRLIAAFRERQPS-------DQAAPLVIHCSAGVGR
|. ....|.| .. | .|. ||||.... .. .| ...|||..||||||| | ...... . || . . |. |...||||||||
..gev.tygdftvtllseehl.ddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgR
TGhfllgTICAIDIVWSMLkqmgldapCFDIFQVVWFLRQHRPA-MVQTEDQYVFVYKAILDL
|| |..|.... ..| ..|....| .||..|| .|||..||.|.|.|.| |
tG.....tliaaylmllll........gvdleeavkllreqRpgkavqtpsqyrflyeallel
|
|||||||||
subfamily_Sponge-PTP8_pd | Subfamily Sponge-PTP8 | 27-291 | 8.6e-70 | 230.3 | In-house | 32-286 (305) | alignment | ||
Range on Protein: 27-291
Range on HMM: 32-286/305.0
YKASTSREEGTTMHTKRKNRYKDIIPYDFNRVVLTTQRSEDedisGSDYINASSVEHGESQCRFIASQGPLPHTLDDFWRMLWEKDVRIVVMACNIFEND
|. ..| . |.. . |.|||.|.|...|..|. ||.. |.| ||||||| |. ... ..|..||||..|..||||...| |. .|| ... |..
yeeeesidvgkkeankaknrlkeitlldddriiltekesld....dsdyinasyvdgykrkkkyivaqgPlkntvadfWrliveekvstivmltklvegg
RFKCAKYWPNLHEF-DVFDEFEVDnMAEDAIDQDFLVRTLKVTH---KGASRIIYQYHYHAWPDHGVPARPGSVMRLIAAFRERQPSDQAAPLVIHCSAG
. || .|||. . |.||.| . . . .|.. | ||.. . || . ||. ||||||| ..|...|| ...| .|. ||..|||||
kdkCrqYWpesktekkefgefsve.lksektasdyieRklkisiededkesrtvlqyqltdWPdhGvpqfatsllslikrvqkdqkkdkgvpllVhCsag
VGRTGHFllgtiCAIDIVWSMLKQMGldapCFDIFQVVWFLRQHRPAMVQTEDQYVFVYKAILDLVQQV
||||| | .|.|| ||. . |.|.|. ||..|. |||| |||||.. |. .|..
vgRtGvf.....iavdialerlkkEe....vvdvfevlkqlRskrmkmvqtldqYvflhdaldelitcg
|
|||||||||
subfamily_Anemone-PTP-5_pd | Subfamily Anemone-PTP-5 | 11-290 | 8.7e-70 | 230.3 | In-house | 23-285 (319) | alignment | ||
Range on Protein: 11-290
Range on HMM: 23-285/319.0
EGFGAEFQRLRDMTAAykastSREEGTTMHTKRKNRYKDIIPYDFNRVVLTTQrsedEDISGSDYINASSVEHGESQCRFIASQGPLPHTLDDFWRMLWE
.. ||. |. .. . .. .. . |.||||..|..|| ||||.. ... |||||||| .. . . .||| |.|| .|..|||||.||
tllekefkllkeavnd.....tfdsaskeenkkknryqnilaydrtrvvlsel....dgvegsdyinasfidgyqerekfiatqaPlentiedfWrmvWe
KDVRIVVMACNIFENDRFKCAKYWPNLhEFDVFDEFEVDNMAEDAiDQDFLVRTLKVTHKGA---SRIIYQYHYHAWPDHGVPARPGSVMRLIAAFRERQ
... |||| ... |. . |. ||||. .| .. .. |. |. .|. .| ||. .| . .| . ...| .||||.|| . |.. |. |. .
eessivvmltklveklkvklkkywpee.nfeeyGrlivtleeeee.ledyiirklklnkkssevetRevkhfqyteWpdhdvPekatslldllkrirksr
PSDQAAPLVIHCSAGVGRTGHFllgtiCAIDIvwsMLKQMGLDApCFDIFQVVWFLRQHRPAMVQTEDQYVFVYKAILDLVQQ
|. |.|.|||||||||| | ...|. || .. ... |.|..| || |. |||...|| |.|.|.|. |.
ektqsgPivvhCsaGvGRtGtf.....ivlda...mlervkeeg.vlDvfstvsrlRtqRnimvqrpeqYkfiyealleavea
|
|||||||||
subfamily_PTPRA_pd | Subfamily PTPRA | 30-288 | 1.7e-69 | 229.2 | In-house | 47-295 (330) | alignment | ||
Range on Protein: 30-288
Range on HMM: 47-295/330.0
STSREEGTTMHTKRKNRYKDIIPYDFNRVVLTTQRSEDEdisgSDYINASSVEHGESQCRFIASQGPLPHTLDDFWRMLWEKDVRIVVMACNIFENDRFK
.. | . |.|||. .|.||||.||.|.... ..| ||||||| .. . . .|||.|||. .|..|||||.||.. .|| .. | .. |
qatlelaskeenkeknrvvnilPydfsrvilsvkeGvee....sdyinasfidGykekdkfiaaqGPkeetvedfwrmiweqksativmltelkerkeek
CAKYWPNLHEF---DVFDEFEVDNMAEDAIDQDFLVRT-LKVTHKGASRIIYQYHYHAWPDHGVPARPGSVMRLIAAFRERQPSDQAaPLVIHCSAGVGR
||.|||. . .. | | .....| ..|||. . |.. .||.. |.|...||| |||. | ...|... .. .. |.|.||||||||
caqywPdeGlvtyGnirvevedetvlvdytvrkflvqqlpdatrekksrlvrqfhftswPdvGvPfepiGmlkllkkvkklnqqsag.pivvhcsaGvGr
TGhfllgTICAIDIVWSMLKQMGLdapcFDIFQVVWFLRQHRPAMVQTEDQYVFVYKAILDLV
|| | ...| | ..| .. |.|..| ||. || ||||. ||.|.||..|.
tG.....tfivldavlervkaerk....vdvfefvkrlrlqrpqmvqtdeqyefiykvlleyy
|
|||||||||
subfamily_Ptp69D_pd | Subfamily Ptp69D | 4-289 | 6.3e-69 | 227.4 | In-house | 15-287 (307) | alignment | ||
Range on Protein: 4-289
Range on HMM: 15-287/307.0
SDQQDALEGFGAEFQRLRDMTAAYKASTSREEGTTMhtkrKNRYKDIIPYDFNRVVLTTQRSEDEdisgSDYINASSVEHGESQCRFIASQGPLPHTLDD
| ..|. .|. |...| . ....| .. .. ||||.||...| .||.|.. ... ||||||| .. . . .|||.|.|. |..|
srkrdtdfglakeyekLeareidkstkvsekkenal....knRyedikafDktRvkLkkingked....sdYinasfikgykekkkfiaaqdPveatigD
FWRMLWEKDVRIVVMACNIFENDRFKCAKYWPNLhEFDVFDEFEVDnMAEDAIDQDFLVRTLKVTHKG-------ASRIIYQYHYHAWPDHGVPARPGSV
||||..|..| ..|| |. | .| |||||||. . ... |. ... .|. |.|.|..|. .|| . |||| .|.| || . ..
fWRmiaeqevtlivmlsnlteknrkkcakYWpie.devqygdilvk.lvseekhsdyiiReldvskkkeesgevedsrkvvqyhytgWkDskvPevargl
MRLIAAFRERQPSDqAAPLVIHCSAGVGRTGHFLlgticAIDIVWSMLKQmgldAPCFDIFQVVWFLRQHRPAMVQTEDQYVFVYKAILDLVQ
..|| || . . .|.|.||||||||.| |. |.|... ||. . |||..| ||..|. .|| .||||.|.|.|| .
lklieqvrelykln.rsPivvhCsaGvgrsgifv.....aldsllqqlka....edkvdifetvkdLrsqRnllvqsleqYvflyralldyss
|
|||||||||
subfamily_Choan-PTP-1_pd | Subfamily Choan-PTP-1 | 4-292 | 1.2e-68 | 226.3 | In-house | 8-280 (281) | alignment | ||
Range on Protein: 4-292
Range on HMM: 8-280/281.0
SDQQDALEGFGAEFQRLRDMTAAYKASTSREEgttmHTKRKNRYKDIIPYDFNRVVLTTQRSEDedisGSDYINASSVEHGESQCRFIASQGPLPHTLDD
. .|. .|| |.. |... |. |... . . ||||..|. || ||..| . .. .|||||. |. ... ..||.|||.|..|..
qlsqndnaGfieeyeklaaigvdntataskad....envlknrYsnivaYDatrvkvtpneenk....ntDYinanfvpgykgekeyiatqgPvPaslva
FWRMLWEKDVRIVVMACNIFENDRFKCAKYWPNLHEFDVFDEFEVDNMAEDAiDQDFLVRTLKV-THKGASRIIYQYHYHAWPDHGVPARPGSVMRLIAA
||.|.||..|...|| . |... || .|||. .. . .. | ..|| . . .. |..|. ...| .| . | .| ||||||||| . .. ..
fWqmvweqkvsaivmvtreieagklkChrYWPddnselkygdvtvkstaeee.katyierkfkleresgetreveqlaytaWPdhGvPattkellefrke
FRERQPSDQAAPLVIHCSAGVGRTGHFLlgticAIDIVWSMLKQMgldAPCFDIFQVVWFLRQHRPAMVQTEDQYVFVYKAILDLVQQVL
.. . ... ||||||||||||||| .. |.| . . .... .. |. .|| ||..| |||| || |||||.|| ... |
vlkltekktkaplvihCsaGvGrtGtyi.....alDrlvkaveae...leeldvkavvaelrkernlmvqtvvqyefvykavldaldkel
|
|||||||||
subfamily_PTPRG_pd | Subfamily PTPRG | 9-300 | 3.1e-66 | 218.8 | In-house | 17-299 (563) | alignment | ||
Range on Protein: 9-300
Range on HMM: 17-299/563.0
ALEGFGAEFQRLRDMTAAykASTSREEGTTMHTKRKNRYKDIIPYDFNRVVLTTQRSEDEDIsgsDYINASSVEHGESQCRFIASQGPLPHTLDDFWRML
. || .||. | |.. . | . |||||| .|..|| || |. ..... |||||. .. . . |||.||||..|.||||||.
gdigfseefealqsetis..kdldaehsqkpenkrKnRylnivaydrsRvklsplpgkkkkl...DYinAnyidGyqkskafiatqgplkdtfddFWrmi
WEKDVRIVVMACNIFENDRFKCAKYWPNlHEFDVFDEFEVDNMAEDAI----DQDFLVRTLKVTHKGA---SRIIYQYHYHAWPDHGVPARPGSVMRLIA
||. | |.|| |. |. | || |||. | .....| ..|. . . . .. ||. .| . ..|||| ||||||| . |. .
WeqnvaiivmitnlvergrrkcdvYWPk.desetygalqvtlieeevlalytvrtlviknlklkkkkqcdteklvrqyhytkWPdhgvPehslpvLifvk
AFrERQPSDQAAPLVIHCSAGVGRTGHFllgtiCAIDivwSMLKQMGlDAPCFDIFQVVWFLRQHRPAMVQTEDQYVFVYKAILDLVQQVLASMDNSAL
.. ..| |.|.|||||||||| . ...| ..|||. . ..|... .| .|. .||||.||.|...|.|.... . .. .
ks.saankaeaGPivvHcsaGvgrtGty.....ivld...tllkqiq.qenavnvfgflkhiraqRnflvqteEqYiflhdalleaiasketellaeqv
|
|||||||||
subfamily_PTPN13_pd | Subfamily PTPN13 | 15-291 | 7.5e-66 | 217.2 | In-house | 15-272 (273) | alignment | ||
Range on Protein: 15-291
Range on HMM: 15-272/273.0
AEFQRLRDMTAAYKAstsrEEGTTMHTKRKNRYKDIIPYDFNRVVLTTQRSededisgsdYINASSV--EHGESQCRFIASQGPLPHTLDDFWRMLWEKD
||. ||.. . .. |.| . . |.||||....||| || | . . ||||| . . |. . ..||.|||||.| .|||.|.||..
eefkelrelkpldtc....evgkkkenkdknryrnvlPydetrvklgdegg.........yinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweqk
VRIVVMACNIFENDRFKCAKYWPNLHE--FDVFDEFEVDNMAEDAIDqDFLVRTLKVTHK--GASRIIYQYHYHAWPDHGVPARPGSVMRLIAAFRERQP
.....| . |... || .|||. .. | . .||... | .| ||.|.|... |.|| . . .. .|||||||. . ......| |. |
aeviamvtlekekgkvkchrywPesknkklkvsnrlevellkvqkld.gfvvralavkdsesgesrevahlnfvkwPdhgvPssaaellqfvaevrrlqt
sdQAAPLVIHCSAGVGRTGhfllgTICAIDIVWSMLKQMGldapCFDIFQVVWFLRQHRPAMVQTEDQYVFVYKAILDLVQQV
.|.|.|.|||||.||.| |. .||.| .... ||. ..| ||. | ..|||.|||.|||||||......
..dagPivvhcsaGiGrsG.....tlitidvvlglierdk....efdvkeivrklreqrqgvvqtkdqyifvykailevlksl
|
|||||||||
subfamily_Urchin-PTP-6_pd | Subfamily Urchin-PTP-6 | 42-287 | 3.8e-65 | 214.9 | In-house | 44-275 (515) | alignment | ||
Range on Protein: 42-287
Range on HMM: 44-275/515.0
KRKNRYKDIIPYDFNRVVLTTQrsedEDISGSDYINASSVEHGESQCRFIASQGPLPHTLDDFWRMLWEKDVRIVVMACNIFENDRFKCAKYWPNLH-EF
.|||||.|.||| .|| | .| |||.||| .. ... .||||||.. ..|||||......| ..| . |.|. ||.||||. .
fkknryknilPydsvrvklevi....ndnPhsdyfnasyipsfdndkayiasqgPnkasvddfWrlvlqenvttiamvtklkegdkikcgkyWPdkpgds
DVFDEFEVDNMAEDAiDQDFLVRTLKVTHKGASRIIYQYHYHAWPDHGVPARPGSVMRLIAAFRERQPsDQAAPLVIHCSAGVGRTGhfllgTICAIDIV
| ...|. .. .| . . . |.|.|.. || . |.|.. |||.||| . |...|| . . . . ||.||||||||||| ...|| |
vkfGsikvelvslea.ctggikrkltvlkgddsrtvtqfhfteWPdkGvpkhtssllklikevkadhg.qythpliihcsaGvGrtG.....vvisidsv
WSMLKQmgldAPCFDIFQVVWFLRQHRPAMVQTEDQYVFVYKAILDL
. |. . |.|..| .||.|| .|||..|| |.| |.|.
vahakt....trmvdvfnfvtnirqkrpylvqtqeqyafiygavled
|
|||||||||
subfamily_PTPN5_RR_pd | Subfamily PTPN5_RR | 32-292 | 5.9e-65 | 214.1 | In-house | 19-272 (274) | alignment | ||
Range on Protein: 32-292
Range on HMM: 19-272/274.0
SREEGTTMHTKRKNRYKDIIPYDFNRVVLTTQRSEDEDisgSDYINASSVEHG-ESQCRFIASQGPLPHTLDDFWRMLWEKDVRIVVMACNIFENDRFKC
..|| . . ...|||||.|.| . ||.|... ||||| |.|||| . | . ..| |||||.|..|||||.....|...|| .. |... ||
dqeeldvfgsqtknryktilPnensrvllesesseded...ssyinanyikGydeeskayvatqGPlpntvadfWrmiyqeevqvivmltklkeaneqkC
AKYWPNLHEF---DVFDEFEVDNMAEdAIDQDFLVRTLKVTHKGASRIIYQYHYHAWPDHGVPARPGSVMRLIAAFRERQPSDQA--APLVIHCSAGVGR
|.|.|. ... . ....|. . .|. ||.| . . .| .. | | .|||| .| .. ....|.. .| . ...| || |.|||||.||
avyfPdaedyeiserygdveikveki.verndysvrklvlkylerersvkhywytdWPdhksPddantlldlvleveesreeenaklapvvvhCsaGiGr
TGHFLlgticAIDIVWSMLKQmgldAPCFDIFQVVWFLRQHRPAMVQTEDQYVFVYKAILDLVQQVL
|| |. ||.| |.. |....| ||..| ||||..|| ....|. ....|
tGcfi.....aisiavrqlre....eivvdvlkivcnlrldrGGmvqtseqyelihralclylkrll
|
|||||||||
subfamily_Urchin-PTP-1_pd | Subfamily Urchin-PTP-1 | 13-288 | 6.7e-65 | 214.0 | In-house | 21-277 (315) | alignment | ||
Range on Protein: 13-288
Range on HMM: 21-277/315.0
FGAEFQRLRDMTaAYKASTSREEgttmHTKRKNRYKDIIPYDFNRVVLTTQrsedEDISGSDYINASSVEHGESQCRFIASQGPLPHTLDDFWRMLWEKD
| ||. | | .|. ..||. .|||||.|.|.| .||.| .|. ||||||| .. ... .|||||||. ..||||||.....
fseefhdlpdPd.iyrqrvaret....infkknryknilPldsarvklevi....ddsPdsdyinasyiksvdddkayiasqgPlkasvddfwrmvlqek
VRIVVMACNIFENDRFKCAKYWPN-LHEFDVFDEFEVDNMAEDAiDQDFLVRTLKVTHKGASRIIYQYHYHAWPDHGVPARPGSVMRLIAAFRERqPSDQ
| .|| . |.|. ||..|||. . | ...|. . .| | | .| | . . .|| . |.... |||.||. . .|...|| . . .
vttivmvtkkqegdkikcrqywPdrkadsvefGsikvellslea.dtdgvarklvtrkseesrtvtqfqftewPdkGvdkqtssllklikevkad.ngkk
AAPLVIHCSAGVGRTGhfllgTICAIDIVWSMLKQmgldAPCFDIFQVVWFLRQHRPAMVQTEDQYVFVYKAILDLV
.|..|||||||||| ...|| | . .|. . |.|..| ||..|| .||||..| |.| |.|. .
efsllvhcsaGvGrtG.....vvisidevvaqikr....trsvdvfnfvknlrakrpylvqteeeyafiydavledl
|
|||||||||
subfamily_Nvec-PTP-2_pd | Subfamily Nvec-PTP-2 | 39-289 | 3e-64 | 211.6 | In-house | 7-243 (250) | alignment | ||
Range on Protein: 39-289
Range on HMM: 7-243/250.0
MHTKRKNRYKDIIPYDFNRVVLTTQRsEDEDisgSDYINASSVEHGESQCRFIASQGPLPHTLDDFWRMLWEKDVRIVVMACNIFENDRFkCAKYWPNlH
.. | |||| |||..| |||| ... |.. ||||||| .. . . |||.||||..|. |||||..|... .|| |. |... . .|||
pqnkeknryadiialdssrvvLekek.gdke...sdyinasflhgyderkafiatqgPlqatiedfWrmvleeksgtivmLtnLkesekt.yhqywPv.e
EFDVFDEFEVDNMAEDAiDQDFLVRTLKVTHK--GASRIIYQYHYHAWPDHGVPARPGSVMRLIAAFRERQPSDQAAPLVIHCSAGVGRTGHFllgtiCA
. . . . |. . .. |. .|.||.... .||. |.|. .||| |||. .|. |. . |. ..||....|||||||.| | .|
kaekyGdvtvsllskee.fadytkrklklskakkaderivrqlhfvvWPdkgvPevatavLellkkvqasqqqagnaPvivqCsaGvgrsGaf.....ia
IDivwSMLKQMGLDApCFDIFQVVWFLRQHRPAMVQTEDQYVFVYKAILDLVQ
|| ..|... . |.|.|. ||..|| .|....||||||..|| ..
id...avlerlkkek.vvdvfkvikvlrkdrphavesleqyvfvyeiilkald
|
|||||||||
subfamily_Urchin-PTPRA_pd | Subfamily Urchin-PTPRA | 3-287 | 2.6e-63 | 209.2 | In-house | 26-292 (319) | alignment | ||
Range on Protein: 3-287
Range on HMM: 26-292/319.0
KSDQQDALEGFGAEFQRLRDMTAAykaSTSREEGTTMHTKRKNRYKDIIPYDFNRVVLTTQRSededISGSDYINASSVEHGESQCRFIASQGPLPHTLD
||| .| | . .||.|. .... . .. . | |||. .|...| |.| | . .||||||| |. .. ..||.||||. ||.
ksdfdddltklevefrracklgvn...ladqtfanldqnkdknriinilafdknvvklerliG....eefsdyinasfvtGyqrkdkyiaaqGPldntla
DFWRMLWEKDVRIVVMACnifendRFKCAKYWPNLHEFdVFDEFEVDnMAEDAIDQDFLVRTLKVTHKG---ASRIIYQYHYHAWPDHGVPARPGSVMRL
|||||.|| .. .|. . ||..|||. . ..|.|. . ... || ......| | | |.|. |||.||| | .|||
dfWrmiweyncstivllt......kdkcsqywplkivi.keerfkvk.vdsveetaeyvvrdielsedgkekdirkitqfhflGwpdvGvpdypsdlmrl
IAAFRE-RQPSDQAAPLVIHCSAGVGRTGHFLlgticAIDIVWSMLKQmgldAPCFDIFQVVWFLRQHRPAMVQTEDQYVFVYKAILD--L
. | .. .. |..|.|||||||||| .. ..|.. ...|. |....| ||| |. .|| || |.| |.|. |
vkkvrhltskenhranivvhcsaGvGrtGvyi.....vldvlldrmke....ekqvdvynfvrdlrqqrntlvqdlvqykfiysalleehl
|
|||||||||
subfamily_PTPRK_pd | Subfamily PTPRK | 40-286 | 8.6e-63 | 207.0 | In-house | 42-275 (314) | alignment | ||
Range on Protein: 40-286
Range on HMM: 42-275/314.0
HTKRKNRYKDIIPYDFNRVVLTTQRSEdediSGSDYINASSVEHGESQCRFIASQGPLPHTLDDFWRMLWEKDVRIVVMACNIFENDRFKCAKYWPNLHE
. ..|||..||..|| ||.|.| . . ||||||. .. . ||. ||||..|. ||||...... .|| .. |. |.|| ||||. |
enreknrsgdilaydrsrvflitidgd....pssdyinaalidsykrpaafivtqgPlqetvkdfWrlvydencasivmltelvevgrvkClkyWPedte
FdvFDEFEVDNMAEDaIDQDFLVRTLKVTH----KGASRIIYQYHYHAWPDHGVPARPGSVMRLIAAFRERQPSdQAAPLVIHCSAGVGRTGHFllgtiC
.....| . . ......||...|.. . . |.. |... .||||.|| ....|.. . |. .| ..|.||||| |||| | .
v..ygdikvelvete.llaelvvrifrveklargqeeirevrqfqflgWpdhdvPvsatgllklvrrvkksqee.eaGrivvhCsaGaGrtGtf.....i
AIDIVWSMLKQMGLdapcFDIFQVVWFLRQHRPAMVQTEDQYVFVYKAILD
||||| |... |. |.|..| ||.... ||.||.||.|.| .||.
aidivldmieregv....vdvfnavktlrsrkvnmveteeqykfiydvile
|
|||||||||
subfamily_PTPN9_pd | Subfamily PTPN9 | 11-289 | 4.5e-62 | 204.7 | In-house | 16-291 (297) | alignment | ||
Range on Protein: 11-289
Range on HMM: 16-291/297.0
EGFGAEFQRLRDMTAAYKASTSREEGttmhTKRKNRYKDIIPYDFNRVVLTTQrSEDEdisGSDYINASSVEHGESQCRFIASQGPLPHTLDDFWRMLWE
.| |.. .|..... .. .|. . .||||.|.. || ||||... .||| ||||||. |. . . ||| ||||..| .|||||.||
rGlskeyaeirnepveGtflasklra....nleknrytdvlcydetrvvlakv.dede...asdyinanfvdGykqkkafiatqGplkktvsdfWrmvWe
KDVRIVVMACNIFENDRFKCAKYWP-NLHEFDVFDEFEVDNMaEDAIDQDFLVRTLKVT--HKGASRIIYQYHYHAWPDHGVPARPGSVMRLIAAFRERQ
..|...||. . |. | ||..||| . .. . | ...| |. |. .|. ||.|... ... || . . . .|||.||| |.. .. . ||.|
qevlvivmttrvvergrlkcgqyWpleeessaefgdlsvsnv.eveeeedykvrvleiknvkteesrkvthfqflsWPdyGvPssaaslldvlekvrekq
PSD------------QAAPLVIHCSAGVGRTGhfllgTICAIDIVWSMLKQMGldapCFDIFQVVWFLRQHRPAMVQTEDQYVFVYKAILDLVQ
. . |.|.|||||.|||| | ...|| | |...| |....| ||. | ..||..||.| |.|.|. .
alavkelgdewkghpsgPPivvhcsaGiGrtG.....tfitldiclsrleevg....tvdvvetvkllrtqrafsiqtpeqyefcylavleyal
|
|||||||||
subfamily_PTPN1_pd | Subfamily PTPN1 | 34-291 | 5.8e-61 | 200.7 | In-house | 25-274 (290) | alignment | ||
Range on Protein: 34-291
Range on HMM: 25-274/290.0
EEGTTMHTKRKNRYKDIIPYDFNRVVLTTQRSededisgsDYINASSVEHGESQCRFIASQGPLPHTLDDFWRMLWEKDVRIVVMACNIFENDRFKCAKY
.| . . . .|||.|. ||| |..| . |||||| || | . ..| .|||||.| | ||.|.||.. . ||| .. |... |||.|
reaklpenrnlnryrdvspydhsrikleradn........dyinaslveleeakrsyiltqGPlpntvdhfWqmvWeqkskavvmlnkvvekeqikcaqy
WPNLHE--FDVFD--EFEVDNMAEDAiDQDFLVRTLKVTH--KGASRIIYQYHYHAWPDHGVPARPGSVMRLIAAFRERQ-PSDQAAPLVIHCSAGVGRT
||. .| ... ...|. ..|. . . ||.|... .| |...|| .||| ||| |.. .... || |.. | |||||||.||.
wPqgeeekellledtklkvkliseer.ksyytvrllelenlktqetreilhfhyttwpdfgvpespaaflkflfkvresGslssdvGpavihcsaGiGrs
GhfllgTICAIDIVWSMLKQMGlDAPCFDIFQVVWFLRQHRPAMVQTEDQYVFVYKAILDLVQQV
| |.| .| . ... . |. . || .|. ||..| ..|| || | | |||. .. .
G.....tfclvdtclvliekkd.dlssvdikkvllelrkyrlGliqtadqlrfsylaileGakvi
|
|||||||||
subfamily_Urchin-PTP-8_pd | Subfamily Urchin-PTP-8 | 37-287 | 1.8e-60 | 199.9 | In-house | 21-256 (284) | alignment | ||
Range on Protein: 37-287
Range on HMM: 21-256/284.0
TTMHTKRKNRYKDIIPYDFNRVVLTTQRSededISGSDYINASSVEHGESQCRFIASQGPLPHTLDDFWRMLWEKDVRIVVMACnifendRFKCAKYWPN
. | |||. .|...| |.| | . .||||||| .. .. ..||.||||. ||.|||||.|| .. .|. . ||..|||.
nldqnkdknrighilafdknvvklerliG....eefsdyinasfitGyqrkdkyiatqGPldntladfWrmiweyncstivllt......kdkcsqywpl
LHEFdVFDEFEVDnMAEDAIDQDFLVRTLKVTHKG---ASRIIYQYHYHAWPDHGVPARPGSVMRLIAAFRE-RQPSDQAAPLVIHCSAGVGRTGHFLlg
. ..|.|. . ... || ......| | | |.|. |||.||| | .|||. | .. .. |..|.|||||||||| ..
kivi.keerfkvk.vdsveeseeyvvrdielsedgkekdirkirqfhflgwpdvgvpdypsdlmrlvkkvrhltskenhranivvhcsagvgrtgvyi..
ticAIDIVWSMLKQmgldAPCFDIFQVVWFLRQHRPAMVQTEDQYVFVYKAILD--L
..|.. ...|. |....| ||| |. .|| || |.| |.|. |
...vldvlldrmke....ekqvdvynfvrdlrqqrntlvqdlvqykfiysalleehl
|
|||||||||
subfamily_Choan-PTP-2_pd | Subfamily Choan-PTP-2 | 37-291 | 3.2e-60 | 198.4 | In-house | 16-267 (270) | alignment | ||
Range on Protein: 37-291
Range on HMM: 16-267/270.0
TTMHTKRKNRYKDIIPYDFNRVVLTTQRSedeDiSGSDYINASSVE-HGESQCRFIASQGPLPHTLDDFWRMLWEKDVRIVVMACNIFENDRFKCAKYWP
.. ..|. |||.||.| ||.| . .. | | . |||| |. ......||..|||| || .||||.||. |. .||. .. |. | ||..|||
eaargkklnRyadiLPsPatRvrleelee...d.sataYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkgrkkCerYWp
NLHEFD-VFDEFEVDNMAED-AIDQDFLVRTLKVTHKGASRIIYQYHYHAWPDHGVPARPG------SVMRLIAAFRE-RQPSDQAAPLVIHCSAGVGRT
. . . . .. .|. . .. .... |....|| .| . ..|..||||||| ... .......| |. .. |.| ||..|||||||||
aepkekvkledgkikvlalseekeegyiltrlrleekgeerrlvHfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkaePllvHcsaGvgRt
GhfllgTICAIDIVWSMLKQMGldapCFDIFQVVWFLRQHRPAMVQTEDQYVFVYKAILDLVQQV
| |. |.||. .|.. . |. ... ||..|.|.||. .|| |.|||.. ....
G.....tlialDiavrlLeetk....kvdvlaiieelRkdRmalvqhpeqyeflykavveyaerr
|
|||||||||
subfamily_PTPN23_pd | Subfamily PTPN23 | 7-292 | 8.6e-60 | 197.0 | In-house | 11-284 (288) | alignment | ||
Range on Protein: 7-292
Range on HMM: 11-284/288.0
QDALEGFGAEFQRLRDMTAAYKASTSReeGTTMHTKRKNRYKDIIPYDFNRVVLTtqrsededISGSDYINASSVEHGESQC-RFIASQGPLPHTLDDFW
| .....|. |.. .. ..| |||..||.||| |||.| | |||||| |.. ..| |||.|.||. || |||
ldgktaldkkfkeleqkqdkearkrsi..aiaklyseknrsrdilPyDhnRvklr........gskDDYinAsfvkdlspgcPdfiatqaPlqstlnDFW
RMLWEKDVRIVVMACNIFENDRFKCAKYWPN-LHEFDVFDEFEVDNMAEDAIdQDFLVRTLKVTHKGAS--RIIYQYHYHAWPDHGVPARPGSVMRLIAA
.|..|. ....|| . | .. |...|||. | .|....| . . . |.||.....|. . . ....||..|||| |....... .
lmvyeqkssviVmllskeelgkpkvdrYwPedkgetvkfgdlsvtlksvret.ethvervlkletldadavksvshlqltsWpelGvPasPetllqflde
FRE---RQPSDQAAPLVIHCSAGVGRTGHFLLGtICAIDIVwsmLKQMGLDapcfDIFQVVWFLRQHRPAMVQTEDQYVFVYKAILDLVQQVL
.. . .|||.|||||||||| | | ..|. . |. || || ||| ||. | |||...|. |.|.|.| ...||
vesayeavqrksktPlvvhCsaGvgRtgvfalv.yaavrel...ekgngll....diiqvvsrlreqRrfmvqekeqlkfsyeavleaarrvl
|
|||||||||
subfamily_Urchin-PTP-5_pd | Subfamily Urchin-PTP-5 | 36-288 | 2.6e-59 | 195.8 | In-house | 43-284 (297) | alignment | ||
Range on Protein: 36-288
Range on HMM: 43-284/297.0
GTTMHTK---RKNRYKDIIPYDFNRVVLTTQRSEDEdisgSDYINASSVEHGESqcRFIASQGPLPHTLDDFWRMLWEKDVRIVVMACNIFENDRfKCAK
.|. . | |.|||.|.|||..|| | .. . |||.||| |. . |.|..| | . |..|||.|.....| ..|| . |.|. |||.
qtvaekkvnfeksRYkniLPydssRvkLaivnddpd....sDyvnasfvkgnkh..rlittqmPmkatvadfWamvldeqvstivmlnddnerdk.kcar
YWPNLHEFDvFDEFEVDNMAEDAIdQDFLVRTLKVTHKG--ASRIIYQYHYHAWPDHGVPA--RPGSVMRLIAAFRERQPSDQAAPLVIHCSAGVGRTGH
||.. | . | .. . . |. |.|.||. | |.. ||.. |||. |. . |.. || |. . . .||..||.|||||||
yWsdkgvtt.fGdvsvvllsvser.eGfikrelevtkgkakarrvvkqyqfveWPdkaverkdsassllklisevrkdfsqnaegPllvhclaGvGrtgv
FllgtiCAIDIVWSMLKQMgldaPCFDIFQVVWFLRQHRPAMVQTEDQYVFVYKAILDLV
. ..|| | . |. |||..| |||.|| .|||..|| |||.|.|. .
l.....ltidsvvaeakre....kevdifglvkklrqerpylvqtkeqykfvyvavleal
|
|||||||||
subfamily_Sponge-PTP11_pd | Subfamily Sponge-PTP11 | 7-291 | 6.2e-59 | 194.2 | In-house | 16-286 (290) | alignment | ||
Range on Protein: 7-291
Range on HMM: 16-286/290.0
QDALEGFGAEFQRLRDmtaaYKASTSREEGTTMHTKRKNRYKDIIPYDFNRVVLTtQRSEDEDISgSDYINASSVEHGESQCRFIASQGPLPHTLDDFWR
. ||| ..|..| . . . . |.| |..||...|..|| ||..| . |...| . .||||. .. . . ..|| |||...|| |||.
akgnegfrnqfkmlds....gesehtvtvgltssnkllnRfanivvyddnritLr.pisghkDCt.neyinAcyikgykekkqyiatqgpvsntlvdFWk
MLWEKDVRIVVMACNIFENDRFKCAKYWPNLHEFDvFDEFEVDNMAEDAIDqDFLVRTLKVTHKGA---SRIIYQYHYHAWPDHG-VPARPGSVMrLIAA
..|...| |.|| .|| |... || .|||. . ..||.. . | ... .. |.|.|..| . .... ||. .|...| |... .... .|.
liwqekvtiivmltniieegkvkCqqYWpdsdtka.ygefsikllneetln.eyierklevknknsagakqsvtqyqitnwdstgkvtnpqtill.viee
FRERQPSDQAAPLVIHCSAGVGRTGHFllgtiCAIDIVWSMLKQMGldapCFDIFQVVWFLRQHRPAMVQTEDQYVFVYKAILDLVQQV
. | . ..|.|||..|||.. | ||... |. | |.|||. .|. .| .|||..|| .... .| ....
myktqrkrgntsivvHCSdtvgrsavf.....caaattinkckteg....vidvfqvlksqRiqkpgsvqtvqqyqgifqivltyldsf
|
|||||||||
subfamily_PTPN3_pd | Subfamily PTPN3 | 39-290 | 6.8e-59 | 194.1 | In-house | 39-277 (280) | alignment | ||
Range on Protein: 39-290
Range on HMM: 39-277/280.0
MHTKRKNRYKDIIPYDFNRVVLTTQRsededisgSDYINASSVEHG----ESQCRFIASQGPLPHTLDDFWRMLWEKDVRIVVMACNIFENDRFKCAKYW
. ||||.||.||| || |. .. .|||||. |. . |.||.||||..| |||.|.||......|| .. |. | || .||
penlsknryrdilpydatrvklkese........tdyinanyvnmeipstglvnryiatqGPlaktatdfWqmvweqksslivmlttlverGrvkChqyW
PNLHEFDVFDEFEVDNMAEdAIDQDFLVRTLKVTHKG--ASRIIYQYHYHAWPDHGVPARPGSVMRLIAAFRERQPSdQAAPLVIHCSAGVGRTGHFLLg
|. .. . ||.| | . .. ...| | ...| .| | | | |||||||| . ...... |. . . . |.|.|||||.|||| ..|
Petedeleygefsvkceke.detksyvlrelvlkdketkeerkilqlqylaWpdhgvPddsadflefvervrklrsg.keePvvvhCsaGigrtGvlil.
ticaIDIVWSMLKQmglDAPcFDIFQVVWFLRQHRPAMVQTEDQYVFVYKAILDLVQQ
... ... . | . . ..| .|. | ..|||..|| || .||| . ..
....letalaliea...aep.vypldivrtmrdqramlvqtasqykfvCeailkvyee
|
|||||||||
subfamily_Urchin-PTP-3_pd | Subfamily Urchin-PTP-3 | 6-288 | 2e-57 | 189.8 | In-house | 19-288 (325) | alignment | ||
Range on Protein: 6-288
Range on HMM: 19-288/325.0
QQDAlEGFGAEFQRLRDMTAAYKASTsreegTTMHTKRKNRYKDIIPYDFNRVVLTTQRsedeDISGSDYINASSVEHGESQCRFIASQGPLPHTLDDFW
|| .|| ||. | . | . . . | |||.|.....| .|||| |.. | . ||||||| .. . |.|.| ||..|..|.|
aqdq.dgfahefgllpsddgiakkva.....mkpenkaknrfknvvaldksrvvletkk....ddpssdyinasylrddkkkdvflaaqaPltatindlW
RML--WEkdvRIVVMACNIFENDRFKCAKYWPNL-HEFDVFDEFEVDNMAEDAIdQDFLVRTLKV--THKGASRIIYQYHYHAWPDHGVPARPGSV---M
|.. |. ||. |..... .||.|||. . | .|| .. . | |.. | |.| ..|| .| . |... .|.| ||. || .. .
rlvldWr...csvvvvlneldlgkdrcavywpkemgksktfGglevklrtieei.sdyvhrvldvkqvkkGetrsvkqfqlqswddmGvqkrpatlisil
RLIAAFRERQPS--DQAAPLVIHCSAGVGRTGHFLlgticAidiVWSMLKQMGLDApCFDIFQVVWFLRQHRPAMVQTEDQYVFVYKAILDLV
.|. | || . ..|...|||||||||| |. . ..|.|... .. |||..| ||..||.||.| |||...|.|. . .
qlvkavservtantkastpilvhcsaGvGrtGvfi.....s...lysalakviees.rvdifgfvkklrkdrpsmvetvdqyiliyealveay
|
|||||||||
subfamily_Urchin-PTP-7_pd | Subfamily Urchin-PTP-7 | 39-287 | 7.7e-57 | 187.6 | In-house | 47-278 (315) | alignment | ||
Range on Protein: 39-287
Range on HMM: 47-278/315.0
MHTKRKNRYKDIIPYDFNRVVLTTQRSEdediSGSDYINASSVEHGESQCRFIASQGPLPHTLDDFWRMLWEKDVRIVVMACNIFENDRFKCAKYWPNLh
.. |.|||| .||.|| || | . ..|||.||. .. . . |.||.|||.. ...||||...|.|. .|| |. |... |. ||||.
ienkqknryiniiaydksrvqlpllend....phsdyvnanfidGynkkrryiaaqgpnvasvkdfwrlvfeedigkivmltnlvegekrkaekywpdk.
eFDVFDEFEVDNMAEDAiDQDFLVRTLKVTHKGASRIIYQYHYHAWPDHGVPARPGSVMRLIAAFRERQpSDQAAPLVIHCSAGVGRTGHFllgtiCAID
.. .. | . |. ... |||| |. . | ..|.|| .||| |||. ..| || . . ......|.|||||||||| | ...|
.kviyGkitvtrkseev.nteytvrtlsvvfgdnirevvqlhytswpdmgvpkytiplmnlirtvkqhh.tnsvgaivvhcsaGvGrtGtf.....itld
ivwSMLKQMGLDApCFDIFQVVWFLRQHRPAMVQTEDQYVFVYKAILDL
..|.|. . |..... .|| | |||. .|| |.|.|.|.
...avldqaeaen.aidvynfitgvrqnrikmvqvaeqyqfiydallet
|
|||||||||
subfamily_Sponge-PTP10_pd | Subfamily Sponge-PTP10 | 4-290 | 5.5e-55 | 181.4 | In-house | 13-280 (287) | alignment | ||
Range on Protein: 4-290
Range on HMM: 13-280/287.0
SDQQDALEGFGAEFQRLRDMTAAYKASTSreeGTTMHTKRKNRYKDIIPYDFNRVVLTtqrsededISGSDYINASSVEHGESQCRFIASQGPLPHTLDD
.... ||| |. | ..| . | . . . | |||...|...| .||.| |||||. .. ... .||....|. .|. .
kghakgnegfknqftvleqvtqredevth...niasqnkdknRltqilvpdnyrvllk........gehpdyinavfidgykekkafiiaesPmfntarn
FWRMLWEKDVRIVVMACNIFENDRFKCAKYWPNLHEfDVFDEFEVDNMAEDaIDQDFLVRTLKVTHKG---ASRIIYQYHYHAWPDHG-VPARPGSVMRL
||...... | ..|| |. |||. .| .|||. . |. |... . |. . .....|.|.|..|. . . . ||.. .|...| |. ... .
fWkliddrnvtaivmlcqekendeevcyqyWpeeks.vvlGeyniellnee.vnagyierklevknknkagdkqqvkqyqitnWdstgkvtepqtillvi
IAAFReRQPSDQAAPLVIHCSAGVGRTGHFllgtiCAIDIVWSMLKQMGldapCFDIFQVVWFLRQHRPAMVQTEDQYVFVYKAILDLVQQ
.. | ...|.|||..|||.. | ||... |. | |.|||. |. .| .||| .|| |.....| ..
eemyk.tqrkrgntsivvhCsdtvGrsamf.....caaattinkckteG....viDvfqvlksqriqkpgsvqtveqykfindivleylds
|
|||||||||
subfamily_PTPRN_pd | Subfamily PTPRN | 25-292 | 2.1e-54 | 179.3 | In-house | 39-296 (297) | alignment | ||
Range on Protein: 25-292
Range on HMM: 39-296/297.0
AAYKASTSRE-EGTTMHTKRKNRYKDIIPYDFNRVVLTTQRSEDEdisgSDYINASSV-EHGESQCRFIASQGPLPHTLDDFWRMLWEKDVRIVVMACNI
.||.| | . . . .. .|||.|...||| .|| |... |... |||||||.. .| . .||.||||..|. |||.|.||. | ..|. ...
cayeaepstkevakaeknvkknrskavlpydhsrvklkeeasaek....sdyinasaildhdprapayiatqgplastvadfwqmvweqGvvvivnltrl
FENDRFKCAKYWPNlHEFDVFDEFEVDNMAEDAIDQDFLVRT--LKVTHKGASRIIYQYHYHAWPDHGVPARPGSVMRLIAAFRErQPSDQAAPLVIHCS
|.. .|..|||. . .|.. .||. ..| .|.|||. || .. .| . |.|. .||..|||| . |.. . ...|.|.|||
eeegvkqckrywpd.eGsevyhiyevhlvsehiwcddylvrsfylknlqtsetrtvtqfhflswpeegvPasaksllefrrkvnk.syrGrscpivvhcs
AGVGRTGHFllgtiCAIDIVwsmLKQMGLDAPCFDIFQVVWFLRQHRPAMVQTEDQYVFVYKAILDLVQQVL
.|.|||| . ..||.| |... . || . ||. || .|.|.||. |...|. . |...|
dGaGrtGvy.....ilidlv...lnrllkGvkeidiaatlehlrdqrpglvktkdqfefaltavaeevnail
|
|||||||||
subfamily_Anemone-PTP-4_pd | Subfamily Anemone-PTP-4 | 40-286 | 1.2e-52 | 173.5 | In-house | 2-237 (237) | alignment | ||
Range on Protein: 40-286
Range on HMM: 2-237/237.0
HTKRKNRYKDIIPYDFNRVVLTTQRSEdedisgSDYINASSVEHGES-QCRFIASQGPLPHTLDDFWRMLWEKDVRIVVMACNIFENDRFKCAKYWPNLH
. | |||| .|. || .|||| |. ||||||. .. . ..||.|||| . ||||.|.|.. ..|| . |... || ||||. .
enkiknrygnivaydhsrvvlkgagsg......sdyinatylkgfdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywpstd
EFDVFDEFEVDNMAEDAIdQDFLVRTLKVTHKGA---SRIIYQYHYHAWPDHGVPARPGSVMRLIAAFRERQPS-DQAAPLVIHCSAGVGRTGHFLLgti
. . . | .... |. ||.| ..... |.|.||.. .|||.||| . ...|. .| | ...| .||||||||||| ||.
qpaaygvltvslkkkeef.sdytvrslllskrltlkevrlihqyqftswpdrgvpqqtaallrfrkniinrsphvsesgpwiihcsagvgrtgiflv...
caIDivwSMLKQMGlDAPCFDIFQVVWFLRQHRPAMVQTEDQYVFVYKAILD
|| .||.| . ||.. |. . . || ..||.|||||....||.
..id...amlrqak.ekkvvdiynyvysieedrpyiiqtkdqyvfihqtile
|
|||||||||
subfamily_PTPN14_pd | Subfamily PTPN14 | 16-289 | 1.2e-51 | 170.5 | In-house | 28-297 (300) | alignment | ||
Range on Protein: 16-289
Range on HMM: 28-297/300.0
EFQRLRDMTAAYKASTSREEgttmHTKRKNRYKDIIPYDFNRVVLTTQRSEdedisGSDYINASSVEH--GESQCRFIASQGPLPHTLDDFWRMLWEKDV
|..|. . . . ||.. . ..|||.||..||. ||| |.... . ..||||||.. | .. .|..||||..|. |||.|.||..|
eyeripkkredallstaklp....enaeknrfkdvlPyednrvelsptken.....stgyinassikvsvggkersyivaqgPleltvqdfWqmvWeqgv
RIVVMACNIFENDRFKCAKYWPNL---HEFDVFDEFEVDNMAEDAIdQDFLVRTLKVTH--KGASRIIYQYHYHAWPDHGVPARPGSVMRLI---AAFRE
...|| .. |. . |. ||.|.| .. |..|.| . . . . ..||. | . | .. | ||||||| . . . . . |.
qlivmlteeeedgkeksfkyfPkleskkktvefgkfkvttkfseds.dsvittglklkhlpskeertvwhlqytDWpdhgvPeDvkgflsyLeevqsvrr
RQ-----PSDQAAPLVIHCSAGVGRTGHFLLGticaiDIVWSMLKQmgldAPCFDIFQVVWFLRQHRPAMVQTEDQYVFVYKAILDLVQ
. . .. |...|||||||||| .| |.. . |.. || .|. ||. | .||| || ||||... ..
ktnseveskeskPPvlvhCsaGvGrtGvlils.....dlliatleh....neeidikkvlarLreqrmllvqtlaqYkfvYkvlikylk
|
|||||||||
subfamily_Choan-PTP-3_pd | Subfamily Choan-PTP-3 | 15-285 | 2.2e-51 | 169.4 | In-house | 14-274 (287) | alignment | ||
Range on Protein: 15-285
Range on HMM: 14-274/287.0
AEFQRLRDM----TAAYKASTSREEgttmhtKRKNRYKDIIPYDFNRVVLTTQRSedediSGSDYINASSVEHGESQCRFIASQGPLPHTLDDFWRMLWE
.|...|.. || .||.. . .|||| |..|.| .||.|... ||||||| | . . .|||.|||.. |. ||||...|
kevdalkedsesstatfkaaeelaa......vkknryadvlPiddtrvllsaege.....lGsdyinanyvasytddeafiaaqgPiaatvrdfwravle
KDVRIVVMACNIFENDRFKCAKYWPNLHEFDVFDEFEVDNMAEDAIDQDFLVRTLKVTHKGAS--RIIYQYHYHAWPDHGVPARPGSVMRLIAAF----R
. . |.. |. | || ||||. . . | . | . .. ||.|.. . . |.. |... .|||.... ...|..
trsasvitmtreveearlkcykywPerevPmrvGGysvvlldydikePeygvralrlidletrearvvkqldllswPdkvlaPtavglirfvldvkqhie
ERQPSDQAAPLVIHCSAGVGRTGHFLLGTICAidivwsmlkQMGLDAPCFDIFQVVWFLRQHRPAMVQTEDQYVFVYKAIL
.. .... |||.|...|.||.| .| .. ....| |. .|| .||..| |.||. |. ..|.|.
lardasevGPlvvhddvGiGrsGillatlvlv.........srledlGrvdvaavvirlreyraalvqavvqlrllyealv
|
|||||||||
subfamily_Sponge-PTP9_pd | Subfamily Sponge-PTP9 | 34-289 | 7.6e-49 | 161.0 | In-house | 33-294 (301) | alignment | ||
Range on Protein: 34-289
Range on HMM: 33-294/301.0
EEGTTMHTKRKNRYKDIIPYDFNRVVLTTQRSedEDISGSDYINASSVEHGESQCRFIASQGPLPHTLDDFWRMLWEKDVRIVVMACNIFENDRFKCAKY
. |.. . |. ||.|.| .|| ||..|..... |.. .||||| .. .. .|||.|||. .|| ||||..|.. . .|| .| |. . || .|
tvglseenkalnrfknitvyddnriilkpkpn..ldlcqreyinasyidgysekkkfiaaqgpmkktlvdfWrliwqekpvsivmvtnlkegtkskceqy
WPN-LHEFDVFDEFEVDnMAEDAIDQDFLVRTLK-----------------VTHKGASRIIYQYHYHAWPDHGVPARPGSVMRLIAAFRERQPSDQAAPL
||| .| . | .|.| . .... ||..| |. |... .|. . |.. ||..|| | |.. | || . .|.
wpnseaeseefgpftvt.lvneqvyPdfvirqlnvkiqdgsnngyierkfkvksdksswdvlqlqvtdWpqdGvvreprtvLqviddvihrqqkigggpv
VIHCSAGVGRTGHFllgtiCAIDIVWSMLKQMGldapCFDIFQVVWFLRQHRPAMVQTEDQYVFVYKAILDLVQ
|.|||..|.|.| . |...| | | |.|||. .|. .| .|.| .||...|..| .|
vVHCSdtVsrsGvY.....csvsiglEQckaeg....VVdvfqvtkavrrskpgaVtTLeqytsiydvidmylq
|
|||||||||
subfamily_CG7180_pd | Subfamily CG7180 | 11-288 | 5.4e-48 | 158.1 | In-house | 13-290 (296) | alignment | ||
Range on Protein: 11-288
Range on HMM: 13-290/296.0
EGFGAEFQRLRDMTAAYKASTSREeGTTMHTKRKNRYKDIIPYDFNRVVLTTQRSEDEdisgSDYINASSVEHGESQCRFIASQGPLPHTLDDFWRMLWE
. | .|.. . .|. . . . | . . |||. ...|||.|||||.. |.. ||||||. |. . .| ..| .|.|.|||....
rkfrveyklelkltprleigdCag.glrkenreknrdvkvvPyDynRvvLekldGeek....sdYinavyvdsflkkkeyivteapkketvdefWrlvyd
KDVRIVVMACNIFENDRfKCAKYWPNLHeFDVFDEFEVDNMAEDAIdQDFLVRTLKVTHK------------GASRIIYQYHYHAWPD-HGVPARPG---
... ||. .. |. . .. .|||| . |..|. . |. .. ||.|.|.| ||. .... |. . ||
eeisavvvLtktfdfak.mypsywpnks.keqygeifveiveekqy.anlkirtfkltkkivalteqekqvkaetRivklfqlteWeledkvPlstnali
SVMRLIAAFRERQ-PSDQAAPLVIHCSAGVGRTGHFllgtiCAIDIVWSMLKQMGldapCFDIFQVVWFLRQHRPAMVQTEDQYVFVYKAILDLV
..| . .||. .. .|.|...| |..|.| . .|||. .... . ..|.|. | ||..|| .|.. ..| ..| .|. |
elrrrvrlwrekvdedpeegPvvvvssdGasRsGvy.....laidanlelvekee....evdvFeavktlrrsRpqLvenveeYkyiYdvlleav
|
|||||||||
subfamily_Urchin-PTP-4_pd | Subfamily Urchin-PTP-4 | 15-286 | 6e-48 | 158.2 | In-house | 24-234 (392) | alignment | ||
Range on Protein: 15-286
Range on HMM: 24-234/392.0
AEFQRLRDMTAaYKASTSREEgttmHTKRKNRYKDIIPYDFNRVVLTTQrsedEDISGSDYINASSVEHGESQCRFIASQGPLPHTLDDFWRMLWEKDVR
||. | . . |. .....| ..|||||.|.||| .||.| .||. |||.||| .. ... .|||||| . .|||||||.....|
eefhdlpgpdi.ypqtvaqke....inlkknryknilpydsarvklevi....ddipdsdylnasyipsfdnekayiasqgpnaaslddfwrmvfqenvt
IVVMACNIFENDrfkcakywpnlhefdvfdefevdnmaedaidqdflvrtlkvthKGA-SRIIYQYHYHAWPDHGVPARPGSVMRLIAAFRErQPSDQAA
..| .. | | || | . |.|. |||..|| . |....| . . . .
tiamvtklkegd...........................................kgddartvaqfhftewPdkdvpkhtssllkfikevka.dfGqyth
PLVIHCSAGVGRTGhfllgTICAIDIVWSMLKQMGLdapcFDIFQVVWFLRQHRPAMVQTEDQYVFVYKAILD
||.||||||||||| . .|| | . |. . |.|..| .|..|| ||||..|| |.| |.|.
pliihcsagvgrtg.....vvisidsvvahakktrm....vdvfnfvtnirrkrpymvqtkeqyafiygavle
|
|||||||||
0041856 | (Phosphotyrosine protein) phosphatases II | 43-288 | 9.7e-48 | 157.5 | In-house | 3-171 (182) | alignment | ||
Range on Protein: 43-288
Range on HMM: 3-171/182.0
RKNRYKDIIPYDFNRvvlttqrsededisGSDYINASSVEHGESQCRFIASQGPLPHTLDDFWRMLWEKDVRIVVMACnifendrfkCAKYWPnlhefdv
||||.||.|||..| ..|||||. . . ..|||| ||||..|. ||.|||.| .....|... . |||
dknrysdilpydhsr..............dldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt.........eelywp.......
fdefevdnmaedaidqdflvrtlkvthKGASRIIYQYHYHAWPDHGVPArPGSVMRLIAAFRErqpsdQAAPLVIHCSAGVGRTGhfllgTICAIDIVWS
. | ..||.|. ||||||| . .. ..| . .| . | ..|||||||||| |..|......
...........................ellerlgiqylylpwpDhgvpd.ldelldfieevle.....eggpvlVHCsaGvgRtg.....tlvaaylmkk
MlkqmgldapCFDIFQVVWFLRQHRPAMVQTEDQYVFVYKAILDLV
. ......| ..|..|| ||.|..||.|.. |.|.|.
l.........gvsleeavklvrsrRpgmvitpnqyfflqlallell
|
|||||||||
subfamily_Nvec-PTP-1_pd | Subfamily Nvec-PTP-1 | 41-286 | 2.8e-47 | 155.9 | In-house | 7-238 (239) | alignment | ||
Range on Protein: 41-286
Range on HMM: 7-238/239.0
TKRKNRYKDIIPYDFNRVVLTtQRSEDEDisgSDYINASSVEH-GESQCRFIASQGPLPHTLDDFWRMLWEKDVRIVVMACNIFENDRFKCAKYWPNLHe
| |||| .|. ||..|||| . |.| ||||||| . | .||.|| . . |||||.|.. ..|| . | . || .|||.
nkaknryanivtydhsrvvle.klsndph...sdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdst.
fDVFDEFEVDnMAEDAIDQDFLVRTLKVTHKGA--SRIIYQYHYHAWPDHGVPARPGSVMRLIAAFReRQPSDQAAPLVIHCSAGVGRTGHFLLgticaI
. .. | . . . |...||. ... | | .||||. |||.||| .|. | .. | | |||||||||||| ||. |
.skycnlrvt.lrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrkit.kdslpgarpwvihcsagvgrtgaflv.....i
DivwSMLKQMGLdAPCFDIFQVVWFLRQHRPAMVQTEDQYVFVYKAILD
| .||.| |||. | .|. || |||| .||||.. |.|.
d...amlrqakk.qktvdifnyvkairedrphmvqtseqyvfihlavle
|
|||||||||
subfamily_Anemone-PTP-1_pd | Subfamily Anemone-PTP-1 | 41-285 | 3.3e-47 | 155.7 | In-house | 8-238 (239) | alignment | ||
Range on Protein: 41-285
Range on HMM: 8-238/239.0
TKRKNRYKDIIPYDFNRVVLTtQRSEDEDisgSDYINASSVEH-GESQCRFIASQGPLPHTLDDFWRMLWEKDVRIVVMACNIFENDRFKCAKYWPNLHe
| |||| .|. ||..|||| . |.| ||||||| . | .||.|| . . |||||.|.. ..|| . | . || .|||.
nkaknryanivtydhsrvvle.klsndph...sdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdst.
fDVFDEFEVDnMAEDAIDQDFLVRTLKVTHKGA--SRIIYQYHYHAWPDHGVPARPGSVMRLIAAFReRQPSDQAAPLVIHCSAGVGRTGHFLLgticaI
. .. | . . . |...||. ... | | .||||. |||.||| .|. | .. | | |||||||||||| ||. |
.skycnlrvt.lrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrkit.kdslpgarpwvihcsagvgrtgaflv.....i
DivwSMLKQMGLdAPCFDIFQVVWFLRQHRPAMVQTEDQYVFVYKAIL
| .||.| |||. | .|. || |||| .||||.. |.|
d...amlrqakk.qktvdifnyvkairedrphmvqtseqyvfihlavl
|
|||||||||
subfamily_Sponge-PTP5_pd | Subfamily Sponge-PTP5 | 37-286 | 2.3e-46 | 152.9 | In-house | 29-264 (283) | alignment | ||
Range on Protein: 37-286
Range on HMM: 29-264/283.0
TTMHTKRKNRYKDIIPYDFNRVVLTTQRSededisgsDYINASSVE---HGESQCRFIASQGPLPHTLDDFWRMLWEKDVRIVVMACNIFENDRFKCAKY
.. . |||||...|.|.| .|| | .. |||||. . . . . ..|..|.|| .| |||.|...... .|| .. |. | ||..|
sadenkrknrnqeivpadqwrvelksesr........dyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfdekitaivmltklqedlrikCsqy
WPNLHEFDvFDEFEVDnMAEDAIDQDFLVRTLKVTHKGA---SRIIYQYHYHAWPDHGVPARPGSVMRlIAAFRERQPSDQAAPLVIHCSAGVGRTGHFL
||. | . || | . .. . | .. | . .... . .. | . | . | | |... . . | . .|.|.|||.|.|||. |.
WPkrGsed.yGeftvt.lrkettsnsfiikelllrvnssakstlllahyqvidWleygeqaiinslvk.fnkvislqteskkgPivvhCstgiGrtavfi
lGTICAIDivwsmlkQMgLDAPCFDIFQVVWFLRQHRPAMVQTEDQYVFVYKAILD
. .... .. | |.|.|| .|..|. .||| ||| .|....|.
.aasasvk.......da.ltesvvdvfavvkimreqrmmavqtldqyklvhelvle
|
|||||||||
subfamily_Sponge-PTP6_pd | Subfamily Sponge-PTP6 | 11-288 | 1.3e-45 | 150.7 | In-house | 20-279 (439) | alignment | ||
Range on Protein: 11-288
Range on HMM: 20-279/439.0
EGFGAEFQRLRDMTAAYKASTSREegTTMHTKRKNRYKDIIPYDFNRVVLTtqrsEDEDISGSDYINASSVEHGESQCRFIASQGPLPHTLDDFWRMLWE
| | .|. . . |.. .| . . . ||||||. ..|. ||.| | . | |||| .. . .||.||| .| |||||...|
eifkeifekinstspdyaciasla..aqeydqtknrykdvgafdhtrvtlq....eipgvphshyinanyikGyyddklyiatqgpkkettddfwrlvie
KDVRIVVMACNIFENdrFKcakYWPNLHEFdVFDEFEVDnmAEDAI-DQDFLVRTLKVTHKG----ASRIIYQYHYHAWPDHGVPARPGSVMRLIAAFRE
| . .|| .|..| .| ||| | .. . | .. | .. .| .|| . | . |.|| ||||. |||. |. .. |
kktvtivmltnlves..yk...ywpsdaev.cygdiavr..vdrnielpnyvirgfkvfnerdttekertvlqfhyiawpdknvpaqashvldflrains
RQPSDQAAPLVIHCSAGVGRTGhfllgTICAIDIVWSMLKqmgLDApCFDIFQVVWFLRQHRPAMVQTEDQYVFVYKAILDLV
. ... |.|.|||||||||| || |.|| || |. || .| .||..| |||. ||||.|.|.|. .
andkeeygpvvvhcsagvGrtG.....tiialdialeqlk...len.kvdikgivkvlrkqrkqmvqalcqyvfiynavledi
|
|||||||||
0051429 | (Phosphotyrosine protein) phosphatases II | 70-290 | 1.4e-44 | 148.1 | In-house | 1-227 (272) | alignment | ||
Range on Protein: 70-290
Range on HMM: 1-227/272.0
ISGSDYINASSVEHGesqC------RFIASQGPLPHTLDDFWRMlWEKDVRIVVMACNIFENDRFKCAKYWP--NLHEFDVFDEFEVDN--------MAE
.. |.||||. | . |...|.||||.| .||||. .| ... .|. .. .| .|.|| .||| ... ....|. . . . .
lplsgyiNardvggy...grvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtlls
DAIDQDFLVRTLKVT---HKGASRIIYQYHYHAWPDHGVPARPgsVMRLIAAFRErqpsdqAAPLVIHCSAGVGRTGhfllgTICAIDIVWsmlKQMGLD
. |...|.| .| . |..| ....||..||||||| . . .|...... |...|||||..||| |..|.... ...|.
eellldyilrellltlllsagearevmhlhytdwpdhgvpqea..llellellld......ggpvlvHCsaGkdRTG.....tvvalllll...lgvsle
APCFD-------IFQVVWFLRQHRPAMVQTEDQYVFVYKAILDLVQQ
. . | ....| ||..||..||||.||.|.|.|.|.|.
tivddYlltnlyleeaveelraqrpgavqteeqylflyeallellrs
|
|||||||||
subfamily_Cele-PTP-6_pd | Subfamily Cele-PTP-6 | 41-287 | 7.5e-44 | 145.0 | In-house | 41-276 (307) | alignment | ||
Range on Protein: 41-287
Range on HMM: 41-276/307.0
TKRKNRYKDIIPYDFNRVVLTTqrsedeDISGSDYINASSVEHGESQCRFIASQGPLPHTLDDFWRMLWEKDVRIVVMACNIFENDRFKCAKYWPNLHE-
||||.|. | .|.|... | |||| | . .||..|||| | .|| | ...| |.| |.. | . || .||| .
ntdknryqdvkcqdkgrivvkf......dglasdyihanylgiaikpkkficaqgplentqysfwamaiqekvesvimlckvielakikceqywpleegq
FDVFDE----FEVDNMAEDA--IDQDFL-VRTLKVTHKGASRIIYQYHYHAWPDHGVPARPGSVMRLIAAFRERQpsdqaAPLVIHCSAGVGRTGhfllg
|| | |.|. . |.|.. | |||| . || | .. .. |||.||| . . |. | | . |.|.||||||||.|
klvfgeapntisvanlgakklapdedlinvttlkvdwaqksrtiqhlqwenwpdrgvpqinltainlleavrydt.....npvvvhcsaGvGrsG.....
TICAIDIVWSmlkQMGLDAPCFDIFQVVWFLRQHRPAMVQTEDQYVFVYKAILDL
|| || .| .| | |. ..| ||..|. .||| ||..... .|.
tivaislvqd...kmiaGinckdmkklveelrsqrhyaiqteaqylylhrvlley
|
|||||||||
0036282 | (Phosphotyrosine protein) phosphatases II | 72-282 | 4.5e-43 | 142.3 | In-house | 1-164 (174) | alignment | ||
Range on Protein: 72-282
Range on HMM: 1-164/174.0
GSDYINASSVEHGESQCRFIASQGPLPhtlddFWRMLWEKDVRIVVMACNIFENDRFKCAKYWPNlhefdvfdefevdnmaedaidqdflvrtlkvTHKG
|||||||| . . |.||.||||. ||.||.| ....||| .. .|....|| ||| ...
gsdyinaspldlsyitprliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe...............................lred
ASRIIYQYHYHAWPDHGVPARPGsVMRLIAAFRERQPSDQAAPLVIHCSAGVGRTghfllGTICAIDIVWSMLKqmgldAPCFDIFQVVWFLRQHRPAMV
.| ..||.| ||||||| . . ... . .| . .|. |...||||||||| ||..|.... .|. . |....| ||..|| ||
lerlgiqylylpwpDhgvpdlsi.llefvkfveealsedpggpvlVHCsaGvgRt.....Gtlvaaylmlrgll.....eslvdaldlvrelRlqrpgmv
QTEDQYVFVYK
||..|| |.|.
qtpsQyrflyy
|
|||||||||
0049772 | (Phosphotyrosine protein) phosphatases II | 40-290 | 5.1e-43 | 143.3 | In-house | 45-282 (314) | alignment | ||
Range on Protein: 40-290
Range on HMM: 45-282/314.0
HTKRKNRYKDIIPYDfNRVVLTtqrseDEDISGSDYINASSVEHGesqCRFIASQGPLPHTLDDF----------WRML--WEKDVRIVVM---------
. ||||.||.|.| |||.| ...||||||||| | ..|||.||||..|..|| ||| .. .||..||
lnrdknryldilpad.nrvilp.....glpvsgsdyinasyvdgf...lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivmsrdevlade
------------ACNIFENDRFKCAKYWPNLHefdvfdefevdnmaedaidqD-------FlvrtlkvthkgaSRIIYQYHYHAWPDHGVPaRPGSVMRL
... .| . .|.....|. . | .| ...|... .||...| . . ..
lsrLdaAlgKtpllildgngneptaadlellk....................eelydpelf............erlgikylripvpDgsap.lledfdef
IAAFRERqpsDQAAPLVIHCSAGVGRTGHFLLGTICaidivwsmLKQMGldapcFDIFQVVWFLRQHRP-----AMVQTEDQYVFVYKAILDLVQQ
.....| |. |...||.||.|||| |.. .. .|..| ... ... ..|. || .... .||.|...|.|....
lefieea...dkggpvlvHCkaGkgRtgtfvvaayl........mkllg.....vsleealedvrlkRpinpnpgfieqleqyefilealleylkf
|
|||||||||
subfamily_ptpA1_pd | Subfamily ptpA1 | 32-235 | 6e-43 | 142.1 | In-house | 38-252 (418) | alignment | ||
Range on Protein: 32-235
Range on HMM: 38-252/418.0
SREEGTTMHTKRKNRYKDIIPYDFNRVVLTTQrsedEDISGSDYINASSVEhGESQCRFIASQGPLPHTLDDFWRMLWEKDVRIVVMACNIFENDRFKCA
|| | |||| .|.| .. || | .| ||||||| .. | .||..||||| |. |||||.||. .||.|| || | ||
etsegdkkhntsknrytnilpvnhtrvqlkki....qdkegsdyinanyid.gaypkqfictqgplpntiadfwrmvwenrcriivmlsresencrikcd
KYWPNLH---EF-------DVFDEFEVDNMA-EDAIDQDFLVRTLKVTHKGASRIIYQYHYHAWPDHGVPARPGSVMRLIAAFRERQ-----PSDQAAPL
.|||. .| .|| . |. . . ... . | ...| .| .| | ||.| |||| .| . . .|. . .|| ||. |.
rywpeqiggeqfsiygngnevfgtysvelveviqdpereiitrnirltfegetrditqyqyegwpdhnipdhtqpfrqllhsitnrqnqiipssdrnvpi
VIHCSAGVGRTGHFLLGTIC
..|||||||||| | |
ivhcsagvgrtgtfctavim
|
|||||||||
0046846 | (Phosphotyrosine protein) phosphatases II | 71-288 | 2.8e-42 | 139.7 | In-house | 10-173 (176) | alignment | ||
Range on Protein: 71-288
Range on HMM: 10-173/176.0
SGSDYINASSVEHGesqcRFIASQGPLPHTLDDFWRMLWEKDVRIVVMACNIFENDRFKCAKYWPNLHEFDVfdefevdnmaedaidqdflvrtlkvthk
..|||||. . . |.|| |||||.|| ||..||.| ....||. .. .| .|.||. ||| |.....
ldldyinanlilgs....rpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgi............................
gasriiyQYHYHAWPDHGVPARpGSVMRLIAAFRERQPSDqaAPLVIHCSAGVGRTghfllGTICAIDIVWSmlkqmgldAPCFDIFQVVWFLRQHRP-A
||... ||||||| ...|... ||.. .. | ..|||||.||| ||..|...... ........ ..|..||
.......qylhlpwpDhgvpdl.elllellefirealkeg..gpvlVHCsaGigRt.....gtlvaayllel........ekglsveealalvreqRplg
MVQTEDQYVFVYKAILDLV
.|||..|| |.|...| |
avqtpeQyrflyefellll
|
|||||||||
subfamily_Cele-PTP-20_pd | Subfamily Cele-PTP-20 | 42-288 | 7.6e-42 | 137.9 | In-house | 57-283 (290) | alignment | ||
Range on Protein: 42-288
Range on HMM: 57-283/290.0
KRKNRYKDIIPYDFNRVVLttqrsedEDISGSDYINASSVEHgeSQCRFIASQGPLPHTLDDFWRMLWEKDVRIVVMACNIFENDRFKCAKYWPNLH-EF
.||||||.. | ||.| .| ||. | |. . || .||.| | |.|||. ...| .|| |...|. . ||..|.|. . |
fkknrykdvvcndktrvil.......kdGydGdyvhanyvkG..lkamfiltqGalkdtvidiwrmvlqekvaaivmlceliedGkakceqyypekeGev
DVFDEFEVDNMAEDAIDQDFLVRTLKVTH--KGASRIIYQYHYHAWPDHGVPARPGSVMRLIAAFRErqpsdQAAPLVIHCSAGVGRTGHFllgtiCAID
| |. | || |.. .|| | . .| . ... .. .|||. |. ...|.. . |. . |.|.|||||.|||| | ||.
ltfGeitvlcseeddkdaniikktlsvrdkdsGkehklkhlkikswpdksvalstlallrtlrilrk.....asGpvvvhcsaGiGrtGtf.....vaie
IVWsmlkQMGLDAPCFDIFQVVWFLRQHRPAMVQTEDQYVFVYKAILDLV
. |. || .|. ..| ||. | . || . ||. . ...|||
vgl....qilldGkeldlldlvralrnsrlnsvqvdiqylalveilldlG
|
|||||||||
0043147 | (Phosphotyrosine protein) phosphatases II | 72-281 | 7.7e-42 | 138.3 | In-house | 4-154 (172) | alignment | ||
Range on Protein: 72-281
Range on HMM: 4-154/172.0
GSDYINASSVEHGESQCRFIASQGPLPHTLDDFWRMLWEKDVRIVVMACNIfendrfkcakywpnlhefdvfdefevdnmaedaidqdflvrtlKVTHKG
|||||||| .. .|||| ||||..||.||||||.|......|.... .. ..
gsdyinasyldlyyipdrfiatqgplrntladfwrmlkelgithivnltel...........................................lydpel
ASRIIYQYHYHAWPDHGVPaRPGSVMRLIAAFRERQPSDQAAPLVIHCSAGVGRTGhfllgTICAIDIVWsmlKQMgldapcfDIFQVVWFLRQHRPAMV
.| ..||.|. ||||||| . ..... .|.. .. | ..|||||||||| |..|..... ... .....| ..|..|| .|
lerlgiqylylpwpDhgvp.llellleflefidellalspggpvlVHCsaGvgRtg.....tlvaaylml...lgl.......sleeavalvrekRpgav
QTEDQYVFVY
|...|| |.|
qnpsqyrfly
|
|||||||||
subfamily_Cele-PTP-13_pd | Subfamily Cele-PTP-13 | 40-287 | 1.8e-39 | 130.1 | In-house | 36-268 (281) | alignment | ||
Range on Protein: 40-287
Range on HMM: 36-268/281.0
HTKRKNRYKDIIPYDFNRVVLTTQRSEDEdisGSDYINASSVEHGESQCRFIASQGPLPHTLDDFWRMLWEKDVRIVVMACNIFENDRFKCAKYWP-NLH
..|||| .| | || | . . . .||| | . . .| .||| | |||||.|... .|| |.. | .| |||.|.| | |
vnnkknrylnipcldisrvqlkvkmpnkn...stdyihanyirspflkrgyiltqgpkketradfwrmiwqenttaivmlcqfletnrekcaeyfprnah
EFDVFDEFEVDnMAEDAIDQDFLVRTLKVTHKGASRIIYQYHYHAWPDHGVPARPGSVMRLIAAFRERqpsdqAAPLVIHCSAGVGRTGhfllgTICAID
||.. |. . .... .. |.....| .|.| .. .. ||| || ..... | | ..| ||||||||||.| |. |..
cclqfdklsvs.yedstvnkslvttrlnlsyegetrlithwlwkewpdwqvpessevmlkilrkirar.....stppvihcsagvgrsg.....tlmave
IVWSMLKQmglDAPCFDIFQVVWFLRQ-HRPAMVQTEDQYVFVYKAILDL
| .. || |.| || | | ||| .||....| .||.
ialqsihs...hftlpdikqivshlrvtgraasvqtlqqymliwkvlldf
|
|||||||||
0049260 | (Phosphotyrosine protein) phosphatases II | 88-282 | 2.6e-38 | 126.4 | In-house | 9-144 (152) | alignment | ||
Range on Protein: 88-282
Range on HMM: 9-144/152.0
CRFIASQGPLPHTLDDFWRMLWEKDVRIVVMACNIFENDRFKCAKYWpnlhefdvfdefevdnmaedaidqdflvrtlkvthkgasriiyQYHYHAWPDH
.||| |||.|.||.||||||.| .....|| .. .|....||..|. ||... ||||
fefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi...........................................qylhlpwpDh
GVPARPGSVMRLIAAFRERqPSDQAAPLVIHCSAGVGRTGhfllgTICAIDIVWsmlkqmgldaPCFDIFQVVWFLRQHRPAMVQTEDQYVFVYK
||| . .. |. . ... |. | ..|||||||||| |..|..... ......| ..|..|| .|....|. |.|.
gvpdlsqlllflllfiekl.aldkggpvlVHCsaGvgRtg.....tlvaaylml..........lgvsleeavalvrekRpgavpnpgqlrflye
|
|||||||||
subfamily_Cele-PTP-10_pd | Subfamily Cele-PTP-10 | 40-287 | 1.3e-37 | 124.1 | In-house | 54-288 (305) | alignment | ||
Range on Protein: 40-287
Range on HMM: 54-288/305.0
HTKRKNRYKDIIPYDFNRVVLtTQRSededisGSDYINASSVEHG-ESQCRFIASQGPLPHTLDDFWRMLWEKDVRIVVMACNIFENDRFKCAKYWPNLH
.. ||||.|. | . | | . | |||| | | . |||..|||| .|.|.|| |. .. | .|| |. | ..|||.||| .
iaitknryqdvpcqdqsavkl.dkps......psdyihanyvgcpmipekrficaqgpldqtidefwwmviqnkveqivmlcktvelgklkcaqywpaaq
--EFDVFDEFEVDNMAED-AI--DQDFLVRTLKVTHKGASRI-IYQYHYHAWPDHGVPARPGSVMRLIAAFRERQpsdqaAPLVIHCSAGVGRTGhfllg
.. |.|.. . | . . .|..|. | .. . . .. ||| ||| . . |..| | . |.|.|||||.||||
geklelksgivvenvsgskpmerdaeiqitllnltysgdqkmsvrhlqwtewpdrgvppckltslellsairgsk.....vpivvhcsagigrtg.....
TICAIDIVwsmLKQMGLDAPCFDIFQVVWFLRQHRPAMVQTEDQYVFVYKAILDL
|| ||. . |... . || . ..| ||..| .|.. ||.|... .|.
tivaieyi...lekiaenkpcppmpelvkalrdqrafsiqndvqylfihrvmlny
|
|||||||||
subfamily_Sponge-PTP1_pd | Subfamily Sponge-PTP1 | 13-292 | 3.6e-34 | 113.0 | In-house | 8-263 (267) | alignment | ||
Range on Protein: 13-292
Range on HMM: 8-263/267.0
FGAEFQRLRDMTAAyKASTSreEGTTMHTKRKNRYKDIIPYDFNRVVLTTQRSEdedisgsdYINASSVEHGESQCRFIASQGPLPHTLDDFWRMLWEKD
. ||. .. .. .. | ... . .||. | .||| .||.| |. | ||||| || . . ||. |.|| | ||. .. ...
iekefelikkisdt.sstis..qsiaeknqernrlddnlpyddtrvilrtkeee........yinasyvegyktknafivtqdplkntitdfltvihdqk
VRIVVMACNIFENDRFKcaKYWPNLHEFDVFDEFEVDNMAEDAiDQDFLVRTLKVTHKGAS-RIIYQYHYHAWPDHgVPARPgSVMRLIAAFRERQPSDQ
| ..|. ..|... . . |.. . .... |. | ..|. . ||.. | | . . |.|. | . .| . |.. . . | .
vpvivlltkvftdnirl..fwPPkmgqakkyqdltvehsleke.endyqiitlelkfknesahnvtlyyykkwnin.tnnkp.ylkplfgilaknqleng
AAPLVIHCSAGVGRTGHFLlgticaidIVWSMLKQMGLDApCFDIFQVVWFLRQHRPAMVQTEDQYVFVYKAILDLVQQVL
|||..||.||||.| || .. |.|... . |||. . .|. |...|.| ..|..... . . . |
nrPlvvacsdGvGrsGtfl........vidsqlerakteg.vsdifdflrkirsqriglvdtkeryiyihellaeyaegrl
|
|||||||||
subfamily_Cele-PTP-8_pd | Subfamily Cele-PTP-8 | 39-287 | 4e-34 | 113.0 | In-house | 41-270 (288) | alignment | ||
Range on Protein: 39-287
Range on HMM: 41-270/288.0
MHTKRKNRYKDIIPYDFNRVVLTtqrsEDEDIsgsdYINASSVEHGESQCRFIASQGPLPHTLDDFWRMLWEKDVRIVVMACNIFENDRFKCAKYWPNLH
. . ..||... |. || |. .| | ||.| | .. . |.| .| || |.. .|.|| |.||. .|| |.. | . | |.|.|
ianptrdryenlprcditrvkls....ddpdf....yiaanvvssakykrrlicaqaPlngtieelWkmllesdveyivmlcellekGkeksaeyfPskl
-EFDVFDEF-EVDNMAEDAIDQDFLVRTLKVTHKGASRI-IYQYHYHAWPDHGVPARPGSVMRLIAAFrerqpSDQAAPLVIHCSAGVGRTGHFLLGTIC
| . . | . ||. | .|.....| .. . . |.. |.|.||| | .||. . . |.|.|.|||||||| . | |
GekarigrlctvvkkkradidklvkvsllriskegeekvivkilhlleWdddgvPenylsplrllevl.....kslqkPivvhssaGvGrtgtlililia
AidivwSMLKQMglDapCFDIFQVVWFLRQHRPAMVQTEDQYVFVYKAILDL
. .|. | | ... ||..| .||| ||..|.. .|.
l.....eslrld..d..flgirsllaklreerfkaiqtemqylyvhrcvlee
|
|||||||||
subfamily_Choan-PTP-4_pd | Subfamily Choan-PTP-4 | 40-199 | 4.3e-34 | 112.7 | In-house | 32-189 (297) | alignment | ||
Range on Protein: 40-199
Range on HMM: 32-189/297.0
HTKRKNRYKDIIPYDFNRVVLTTQrsededISGSDYINASSVEH--GESQCRFIASQGPLPHTLDDFWRMLWEKDVRIVVMACNIFENDRFKCAKYWPNL
. |||||.||. .| .|| | |...||||| | |.. ..| .|||| |.||||....|.|||..|| ... |. | ||| |||.
sslrknryrdilatddtrvkllrv......iterdyinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmvaklqedGrdkcapywpsv
H-EFDVFDEFEVDNMAEDAID--QDFLvRTLKVTHKGASRIIYQYHYHAWPDHGVPARPGSVMRL
| .. |. ... . . . .| |.. .. || . . .|||||||. . |.
vqerlkagdvvveflsstsdefdrvil.telqliyrsesrvvrhvqflswpdhGvpsdledlvrf
|
|||||||||
subfamily_Cele-PTP-18_pd | Subfamily Cele-PTP-18 | 12-290 | 1.1e-33 | 111.3 | In-house | 23-289 (305) | alignment | ||
Range on Protein: 12-290
Range on HMM: 23-289/305.0
GFGAEFQRLRDMTAAYKASTSREegttMHTKRKNRYKDIIPYDFNRVVLTTQRSededisgSDYINASSVEHGESQCRFIASQGPLPHTLDDFWRMLWEK
|. |||. .. . | . .| . ||||||. | ||| | . .|| | | ||| .| || .| ||| | ...
glraefvamkrfndfekmkafke....aqeagknrykdvgcldnnrvklegpwp.......heyihanyvstptnpkrfictqaplektcadfwymclqd
DVRIVVMACNIFENDRFKCAKYWPNLHE-FDVFDE--------FEVDNMAEDAIDQDFLVRTLKVTHKGA---SRIIYQYHYHAWPDHGVPARPGSVMRL
| . | ||. | ||..|.. .. |.| || . . | . |. ... .|. .| . .||. ||| |||| ... |
kveaifmlcnllekgakkcleyfaskdkdvlefeekgqkisvkfessvtlkfrkdakakvtetvlviegpgekarkvthyhwidwpdrgvpaadlailel
IAAFRerqPSdqAAPLVIHCSAGVGRTGHFLLgticaIDIVwsmLKQMGLDAPCFDIFQVVWFLRQHRPAMVQTEDQYVFVYKAILDLVQQ
.. | || |.|.|||||.|||| .. .. . |.|. | ... .|. | .||..||.||.. ||. ...
lekar...ps..kgpivvhcsagigrtgsvvm.....leyi...ldqllagqiiedtdkilqkireqrnnsiqtdaqylfvhqvilnyfrk
|
|||||||||
0051082 | (Phosphotyrosine protein) phosphatases II | 73-284 | 4.2e-33 | 109.4 | In-house | 3-149 (151) | alignment | ||
Range on Protein: 73-284
Range on HMM: 3-149/151.0
SDYINASSVEHGesqcrFIASQGPLPhtldDFWRMLWEKDVRIVVMACNIFENDrfKCAKYWPNLHefdvfdefevdnmaedaidqdflvrtlkvthkga
|||||.| |. | ...|.|||. ||...|.| ... .|. .. .|.. .|..|.|.|
sdyinfsyvtgg.....lyrsggpla....dflellkelgiktivnlrseeerg..ycpeylpelg..................................
sRIIYQYHYHAWPDHGVPARPGSVMRLIAAFRErqpsDQAAPLVIHCSAGVGRTGHFLLGTICAIDivwsmlkqmgldapcFDIFQVVWFLRQHRPAMVQ
. ....... |||.|.| . .|.... .... .. |...|||||.|||| . . ... . ....... ..|..|| .||
.ievlhipildwpdpglplsfdavleflellld....kkngpvlvHCsaGkgRTGtlvalylmllg...............vsleealeeyrlkrpgvvq
TEDQYVFVYKAI
...|..|...|.
pnqqflfqlfal
|
|||||||||
0044763 | (Phosphotyrosine protein) phosphatases II | 52-285 | 1.5e-32 | 108.0 | In-house | 1-168 (178) | alignment | ||
Range on Protein: 52-285
Range on HMM: 1-168/178.0
PYDFNRVVLTTQrsedEDISGSDYINASSVEHGesqcRFIASQGPlphtlDDFWRMLWEKDVRIVVMACNIFENDRFKCAKYWPNLHEfdvfdefevdnm
|.|..||.|.. |.. .||||||| . .| ...|..| |....|.| ... .|. .. .|. ..|| .||| ..
pldrtrvllsnl....eglersdyinaseilpg....lylgslpp.....addlellkelgithivnlteelelgflkcdpywpeeag............
aedaidqdflvrtlkvthkgasriiYQYHYHAWPDHGVPARPGSVMRLIAAFRERQPsDQAAPLVIHCSAGVGRTGHFLlgticAIDIVWSMlkqmglda
.||.. .|||||| . ....... .| .. .. | ..||||||||.| . |.......
.........................iqylhipipDhgvpdllehflefvefieeald.ekggpvlVHCsaGvgRsgtlv.....aaylmkkl........
pCFDIFQVVWFLRQHRPaMVQTEDQYVFVYKAIL
....... ..|..|| .|....|. ..|. |
.glsleeaielvrerRp.ivpnpgqlrqLyefel
|
|||||||||
PTPc_DSPc_SM00012 | 176-285 | 5.9e-32 | 105.4 | In-house | 2-104 (105) | alignment | |||
Range on Protein: 176-285
Range on HMM: 2-104/105.0
IYQYHYHAWPDHGVPARPGSVMRLIAAFRERQPSDQ-AAPLVIHCSAGVGRTGhfllgTICAIDIVWSMLKQMGldaPCFDIFQVVWFLRQHRPAMVQTE
...|||..||||||| .. |...|..|... . . ..|.|.|||||||||| |..|.||....|.. ..||||.|. ||..|| |||||
vkhyhytgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtg.....tfvaldillqqleket...kevdifqivkelrkqRpgmvqte
DQYVFVYKAIL
.||.|.|.|.|
eqylflyrall
|
|||||||||
subfamily_Cele-PTP-15_pd | Subfamily Cele-PTP-15 | 44-286 | 9e-30 | 98.6 | In-house | 38-268 (285) | alignment | ||
Range on Protein: 44-286
Range on HMM: 38-268/285.0
KNRYKDIIPYDFNRVVLTTQrseDedisgSDYINASSVE-HGESQCRFIASQGPLPHTLDDFWRMLWEKDVRIVVMACNIFENDRFKCAKYWPN-LHEFD
||| |. . |||| . | ||| || . |. | .|..||||| || |||.|.... . |.| | .|| ||| |.|. | |
lnryadvrcieetrvvlknh...d.....rdyihaswmrmpgkdqstyittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekcalyypeklgevv
VFDEFEVD--NMAEDAIDQDFLV-RTLKVTHKGASRIIYQYHYH--AWPDHGVPARPGSVMRLIAAFRERQPSDqaAPLVIHCSAGVGRTGHFLlgticA
| ..|. . |.|| | |. | .| .| | . |||. | .. | .. .| . |...||||||||| |.
kfgkyeitlteckeeaiagtilnaltvintedasseplymnhvqvpwwpdqlapedarpmielykwvkkvnpke..kpicvhcsagvgrtatfv.....g
IDivWSMLKQMglDAPCFDIFQVVWFLRQHRPAMVQTEDQYVFVYKAILD
|| .. .. | . | .....| .| | ||. |..|.| ...
id..yatirim..enpniemldivremramrfqavqshmqflflyvvlme
|
|||||||||
subfamily_Cele-PTP-19_pd | Subfamily Cele-PTP-19 | 42-280 | 3.5e-29 | 96.5 | In-house | 51-273 (301) | alignment | ||
Range on Protein: 42-280
Range on HMM: 51-273/301.0
KRKNRYKDIiPYDFNRVVLTTQRSEDEDISgSDYINASsvehGESQcRFIASQGPLPHTLDDFWRMLWEKDVRIVVMACNIFENDRFKCAKYWPNLHEFD
| |.||. . | . . | . . | ...|..| |... ||||.||||. | .||| || || .|| .. |. ||..| | . .
kdkhryptv.PckPstavevivdGkrvPih.anwipts....Ghph.rfiatqgPlkntsedfwamlvqydvekivmlgqkvekleekceeylpvkisek
V-FDEFEVDNMAEDAIDQD-FLVRTLKV---THKGASRIIYQYHYHAWPDHGVPARPGSVMRLIAAFRErqpSDqaAPLVIHCSAGVGRTGHFLlGTICa
. . |.. .. | .. |||.| | | |.| . | |. |.|.||| .. |. .. |. |.|.|||||.||. |. || .
ldigrfkikiknkelilnkkiskrtlevedstgkfatrtvthyqysewtdrgvPkshaelfdlmelvkk...se..kPivvhcsaGiGrsvafi.gtey.
idivwsmLKQMGLDAPCFDIFQVVWFLRQHRPAMVQTEDQYVFV
| . . | .. . . ||.|| |||. | ..
.......lareveadptieltealkhlrehrwngvqtnsqlywm
|
|||||||||
subfamily_Cele-PTP-14_pd | Subfamily Cele-PTP-14 | 40-285 | 2.7e-28 | 93.4 | In-house | 51-287 (310) | alignment | ||
Range on Protein: 40-285
Range on HMM: 51-287/310.0
HTKRKNRYKDIIPYDFNRVVLTTQRSEDEdisgsDYINASSVEHGESQCRFIASQGPLPHTLDDFWRMLWEKDVRIVVMACNIFENDRFKCAKYWPNLHE
. |||| |.. | || |. ..| | ||| | | . || ||||| ||. |||||.... ... |.. |. | || ||| |
kymhknrysdvvcldtsrvklkidksrye.....dyihanyvktnylrstficsqgplqhtiidfwrmifqeraesilllckvgeegrpkcvgywpslgv
FDVFDEFEVDNMAEDAidQDFLVRTLKVT---------HKGASR---IIYQYHYHAWPDHGVPARPGSV--MRLIAAFRErqpsdqaAPLVIHCSAGVGR
. . | |..| . ..| . | || . | . .. ||| ||| ||.| | | |.|||||..|
tetygcirvtnlsess..eefeicnlavtfvpdnvpvdeqpanlkelrvslikwpnwpdrgvpdekchtvpqrllaqvrh.......gpcvvhcsagkdr
TGhfllgTICAIDIVWSMLKQmGLDapcFDIFQVVWFLRQHRPAMVQTEDQYVFVYKAIL
.. ...|... . |.. || |. .|. |...| .||| ||... . .
ly.....vvvalklkidkldr.glk...vdaeevktellksraiciqtelqyliidrvri
|
|||||||||
subfamily_Fungi-PTP1_pd | Subfamily Fungi-PTP1 | 40-138 | 2.1e-27 | 90.8 | In-house | 46-154 (350) | alignment | ||
Range on Protein: 40-138
Range on HMM: 46-154/350.0
HTKRKNRYKDIIPYDFNRVVLT----TQRSEDEDISGSDYINASSVEHG------ESQCRFIASQGPLPHTLDDFWRMLWEKDVRIVVMACNIFENDRFK
.. |||||.|.||. .|| | . . . .|..|||||. .. ... ..|| |.||| |.|||.... . .|..... . .|... |
elfaknrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvkvilsltsdvelnlek
CAKYWPNLH
| .||...
cyrYWqegs
|
|||||||||
subfamily_egg_pd | Subfamily egg | 35-296 | 2.7e-27 | 90.2 | In-house | 34-278 (307) | alignment | ||
Range on Protein: 35-296
Range on HMM: 34-278/307.0
EGTTMHTKRKNRYKDIIPYDFNRVVLTTQRSEDEDisgsDYINASSVEHGESQCRFIASQGPLPHTLDDFWRMLWEKDVRIVVMACNIFENDrfKCAKYW
. . . | | | . |. || | .| | |.| | |. . || .| || | ||||||.....|. .|| |.. .| ||
taasdnnlekarskrvhckdssrvklelrrGqyld....dfihanrvkGkpllnefilaqaplkntvddfwrmvfqeevqyivmltsrkese..rceyyw
PNLHE-FDVF--DEFEVDNMA-EDAIDQDFLVRTLKVTHKGASRIIYQYHYHAWPDHGVPARPGSVMRLIaafreRQpsdQAAPLVIHCSAGVGRTGhfl
|. .. |. ....|. ... | | | ||. .. . . | |.|.. |. . | |... || ...
pkaesdslvtvpGslrienlkvdskadplfrvtklklvGgddeerflehwqgdvnnssdvysplrvlrkl.....rn...lskpvvvqdilGvskaa...
lgTICAIDIVW-SMLKqmGlDAPCFDIFQVVWFLRQHRPAMVQTEDQYVFVYKAILDLVQQVLASMD
|. ||.| |.|. | . . . | |||..|. |.. .|.|||. .| ....|..|
..tlvaieiallsllr..G.pitkslvlravvflrlrrrlsvesvllylfvyrlvlfffrdvigsak
|
|||||||||
subfamily_Cele-PTP-11_pd | Subfamily Cele-PTP-11 | 34-289 | 3.2e-26 | 86.8 | In-house | 35-277 (312) | alignment | ||
Range on Protein: 34-289
Range on HMM: 35-277/312.0
EEG-TTMHTKRKNRYKDIIPYDFNRVVLTTqrseDEDIsgsdYINASSVEHGESQCRFIASQGPLPHTLDDFWRMLWEKDVRIVVMACNIFENDRFKCAK
| . .. | ||| .| .| | |. ||.. || | | ||...|||| | ||.. ... | . |. ||||
sectaflkfkdlnrypniqcwdrgrftlag....denf....yihanfvkictkperfvctqgplentcthfwqlalslgstsiillcgfvedgsekcak
YWPNL------HEFDVFDE----FEVDNMAEDAIDQDFLVRTLKVThkGASRIIYQYHYHAWPDHGVPARPGSVMRLIAAFRErqpsdQAAPLVIHCSAG
| .. . |. | |. . | | . | .| | | . .| . .|||||.| . .||..| . . |.. |||||
yisdivgfvdledhrvyteycteieiggkskdkithrvlkvvvkat..gqesklnhyqwaswpdhgmpdscdtalrllsavkk.....dkkpviahcsag
VGRTGhfllgTICAIDIVWSMLKQMGlDAPCFDIFqvvWFLRQHRPAMVQTEDQYVFVYKAILDLVQ
||||| |.. |. . . |.. |.| .||. | |.. |||.. ...|...
vgrtg.....tlaliesmiaalrhpr.kqnvkdsf...vllrkdrarsvrvfpqyvyalrcvlefly
|
|||||||||
subfamily_CG42327_pd | Subfamily CG42327 | 38-201 | 1.1e-25 | 84.9 | In-house | 25-188 (319) | alignment | ||
Range on Protein: 38-201
Range on HMM: 25-188/319.0
TMHTKRKNRYKDIIPYDFNRVVLTTQRSEDEDisgsDYINASSVE-HGESQCRFIASQGPLPHTLDDFWRMLWEKDVRIVVMACNIFENDRFKCAKYWPN
. .| |.|. ...| |||| . ..|.| |..|| | . .... .||.| .| . ||||..||. |..| .....|. .||.|.|
PvtskdksrvinvvPlPetrvvlqrigdddkd....eyldasyvrGyddapnsyiaaqvsledsssdfwrtvweqqsrvivqltdlselGikvcaeylPt
L---HEFDVFDEFEVDnMAEDAIDQDFLVRTL--KVTHKGASRIIYQYHYhAWPDHGVPARPGSVMRLIA
. ... .. | . . .... ... || | .| || . | | |.. .||| . ... ..
ketldntslyGdilvt.lkgrevkdryaistlllkrvdkeesrelthywy.kwleaevPaeeaaliamll
|
|||||||||
0048076 | (Phosphotyrosine protein) phosphatases II | 161-286 | 2.7e-23 | 77.7 | In-house | 32-141 (145) | alignment | ||
Range on Protein: 161-286
Range on HMM: 32-141/145.0
LVRTLKVTHKGASRIIYQYHYHAWPDHGVPARPGSVMRLIAAFRERQPSDqaAPLVIHCSAGVGRTGHFLlgticAIDIVWSmlkqmgldaPCFDIFQVV
.| .| . .. .| ..||.| ||||||| . ....... .| .... | ..|||||||||| . |...... .......
tvlnltselellerlgiqylylpwpDhgvpdllellleflefieealkeg..gpvlVHCsaGvgRtgtlv.....aaylmll.........lgvsleeal
WFLRQHRPAMVQTEDQYVFVYKAILD
..|..|| .|....|. |.|...|
elvrsqrpgavpnpgqlrflyefele
|
|||||||||
subfamily_Urchin-PTP-2_pd | Subfamily Urchin-PTP-2 | 173-287 | 5.3e-22 | 72.7 | In-house | 88-193 (440) | alignment | ||
Range on Protein: 173-287
Range on HMM: 88-193/440.0
SRIIYQYHYHAWPDHGVPARPGSVMRLIAAFRERQPSDQAAPLVIHCSAGVGRTGhfllgTICAIDIVWSMLKQmgldAPCFDIFQVVWFLRQHRPAMVQ
|| . ||||..|||.||| | |...| | | .||..|||||.|||| | |.| . |. . ||| .. .|. || |||
srtlkqyhyqgwpdkgvpkfagpvlkmiqdvnesqekagngpllvhcsagagrtg.....viiavdsilreakr....sdqidifsfinsmrnnrpqmvq
TEDQYVFVYKAILDL
| .||.||..|.|.
tpeqyafvheavleg
|
|||||||||
0048179 | (Phosphotyrosine protein) phosphatases II | 154-282 | 1.8e-21 | 71.8 | In-house | 48-139 (144) | alignment | ||
Range on Protein: 154-282
Range on HMM: 48-139/144.0
DaidqdflvrtlkvthkgasriIYQYHYHAWPDHGVPARPGSVMRLIAAFRERQPSDqaAPLVIHCSAGVGRTghfllGTICAIDIVWsmlkqmgldAPC
..||.. ||||||| . . .......| .... | ..||||||||| ||..|.....
e.....................giqylhlpwpDhgvpdllellleflefieealeeg..gpvlVHCsaGvgRt.....gtlvaaylmk.........klg
FDIFQVVWFLRQHRPAMVQTEDQYVFVYK
....... ..|..|| .|....|. |...
lsleealalvrsrrpgavpnpgqlrfLle
|
|||||||||
subfamily_Cele-PTP-16_pd | Subfamily Cele-PTP-16 | 41-287 | 1.6e-20 | 67.9 | In-house | 47-278 (303) | alignment | ||
Range on Protein: 41-287
Range on HMM: 47-278/303.0
TKRKNRYKDIIPYDFNRVVLTtqrseDedisgSDYINASSVEHgESQCRFIASQGPLPHTLDDFWRMLWEKDVRIVVMACNIFENDRFKCAKYWPNLHEF
|||. |.| | .| |. | | || || .| .|. . | .| ||.|| |||.|. |. |. |.. | |.. .|. .|
nmdknrfvdvicldhskvkls.....d.....ssyihasylel.dsskkailtqlplshtaadfwqmiieqkvkcvlllltdseydklggdsvfprnqdf
DVFDEF--EVDNMAEDAIDQDFLVRTLKVTHKGASRIIYQYHYHAWPDHGVPAR--PGSVMRLIAAFRERQPSDQAAPLVIHCSAGVGRTGHFLLGTICA
|.| | .. . . . . .. | |. ... .||.||| .|. | | .. . .. | | .|.||.| | | .
lkfeersirvgefkrvelgdgwvlkvlsvsngdyksflhvhhykawphnsipsdgspkfvkqiwqlqsvlrkysdstptvymslsgcgragtfalfetah
IDIvwsmlKQmglDAPCFDIFQVVWFLRQHRPAMVQTEDQYVFVYKAILDL
. . .. . ...|. ... .|. | || |. .|| . .
lsl.....hs...eqasldlvkclenvrngrlhavqnlsqfsvvytllaeh
|
|||||||||
subfamily_Cele-PTP-1_pd | Subfamily Cele-PTP-1 | 73-296 | 1.1e-19 | 65.7 | In-house | 46-267 (290) | alignment | ||
Range on Protein: 73-296
Range on HMM: 46-267/290.0
SDYINASSVEHGESQcRFIASQGPLPHT-------LDDFWRMLWEKDVRIVVMACNIFENDRF----KCAKYWPNLHEFD-VFDEFEVDNmAEDAIDQDF
.||| |. | . . |.|..| |. .. . .|| | . |. ||| |. |... |||| |. . . |. ..| . ..|.
ddyiHAnrvtcpngl.rliltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCakYvpesvgeelkfkgltvkC.kskekeddv
LVRTLKVTHKGASRI-IYQYHYHAWPDHGVPARPGSVMRLIAAFRerqpsDQAAPLVIHCSAGVGRTGhfllgTICAIDIVWSMLKQMGLDapcFDIFQV
.|.| |.. . . . .. | . |. . ... || . . .| ..|| |. | .. ||.. . .. .. . . . .|
etRelvvkfddeeeftvtHsllkgWnklnvqedtktllsliqkvk.....asktpvivHcvdGiSrsA.....alaaiilgyQkiaetsgs...vkledv
VWFLRQHRPAMVQTEDQYVFVYKAILDLVQQVLASMD
. ||..| ..... .. || .|. |...|| ..
lkalrkqralaitsalelafvdagivllaievldqfa
|
|||||||||
subfamily_Cele-PTP-4_pd | Subfamily Cele-PTP-4 | 44-289 | 2.2e-19 | 64.0 | In-house | 54-286 (302) | alignment | ||
Range on Protein: 44-289
Range on HMM: 54-286/302.0
KNRYKDIIPYDFNRVVLTTQRseDedisgsDYINASSVEHGESQCRFIASQGPLPHTL---DDFWRMLWEKDVRIVVMACNIFENDRfKCAKYWP-NLHE
||. .|. .| |.| |... | .|.|||.|| | . | .| | . ..|||| ... . ||.. | .. ...| . .
knqsedvpildsnlvkleaep..d......syvnaskvevPeltrsiilaQlpkvdsedsveeFWrmvfqekivsvvilvgeeelkk.tlselfpkksgd
FDVFDEFEVDNMAEDAIDQDFLVRTLKVTHKGASR--IIYQYHYHAWPDHGVPARPGSVMRLIAAFrERQPSDQAAPLVIHCSAGVGRTGHFLLGTIcAI
. .... | | . ... .. | .| | .. |. . |... || . ..... .| . .. ...|| |.|| | || .. |.
ykeygkmfvNnrkVekaeeektryviEvlPegcsnsvlanvyvltnWkqkkvpvkyaeliktaakv.fakkikadentvivSknGaGRagafltlav.av
DIVwsmlKQMglDAPCfdIFQVVWFLRQHRPAMVQTEDQYVFVYKAILDLVQ
. . .. ..|. | ..| .|. ||..|.. .|||..| |.| ...
ekl....qkg..kepn..ikeivksiRsqRpravdslkQyvslyialllyik
|
|||||||||
subfamily_Cele-PTP-9_pd | Subfamily Cele-PTP-9 | 97-289 | 2.4e-19 | 64.4 | In-house | 39-222 (255) | alignment | ||
Range on Protein: 97-289
Range on HMM: 39-222/255.0
LphTLDDFWRMLWEKDVRIVVMACNIFENDRFKCAKYWPNlhEFDVFDEFEVDNMAEDAIDQDFLVRTLKVTH----KGASRIIYQYHYHAWPDHGVPAR
| |.| |.... .. ||| |. |... || .|.| | | .. |.. .| ..|||..| | . . |.|. |... |
l..tvdkfyqtivqtktevvvmlcdfaeegvekcssyfpl..ekdeklkladvnvtttkssadvvlrtleitstlgekkkthtvkhysykGWieknaPel
PGSVMRLIAAFRErqpSdqaAPLVIHCSAGVGRTGHFLlgticAIDIVWS-MLKQMGL-DAPCFDIFQVVWFLRQHRPAMVQTEDQYVFVYKAILDLVQ
. .. .. . |. | ..|.|||.|.||. | ...|. |.... .. .| ... ||..|.. ..| | | .||||
areilnilkvvrd...s...ksvvvhCstGiGrsaafv.....laelvyqkmirsldttetveldylslleelrskrkraihtPlqlafsilmvldlvf
|
|||||||||
subfamily_Fungi-PTP1_pd | Subfamily Fungi-PTP1 | 172-287 | 1.5e-18 | 61.6 | In-house | 213-343 (350) | alignment | ||
Range on Protein: 172-287
Range on HMM: 213-343/350.0
ASRIIYQYHYHAWPDHGVPARPGSVMRLIA---------AFRERQPSDQAAPLVIHCSAGVGRTGHFL-----LGTICAIDIVWSMLKQMGLDAPCFD-I
..|| ... |.| .. .| |... . .. .....|...|||||||||| .. | . .. . ... | .| |
dPyvvyqlqvknWkDlslllnPesilqalevkndliddlfaeshldnarsspilvhCsaGvGrtGtlvtlDsllsdfeilenltkesrkldvaaktrDli
FQVVWFLRQHRPAMVQTEDQYVFVYKAILDL
...| ||. | |||. ||..|.|.|.| .
siivnelrkqrismvqnldqfifiYeallfy
|
|||||||||
subfamily_hpo-7_pd | Subfamily hpo-7 | 97-296 | 8.6e-18 | 59.2 | In-house | 43-235 (263) | alignment | ||
Range on Protein: 97-296
Range on HMM: 43-235/263.0
LPHTLDDFWRMLWEKDVRIVVMACNIFENDRFKCAKYWPNlhEFDVFDEFEVDNMAEDAIDQDFLVRTLKVTH----KGASRIIYQYHYHAWPDHGVPAR
| |.| |.... . ||| |. |... || .|.| | | .. |.. . .| |..||... | . . .| | |... |
lvqtidkfyqtivqtktevvvmLcDfneegvekcssyfPl..ekdekqklanvnvcttkvqsdvllktlellstlgeKkkthtvkhysykgWiekndpel
PGSVMRLIAAFRERQpsdqaaPLVIHCSAGVGRTGHFLLgticaIDIVWS-MLKQMGL-DAPCFDIFQVVWFLRQHRPAMVQTEDQYVFVYKAILDLVQQ
. ...... . |. . .||.|||.|.||. | . ...|. |.... .. .| ... ||..|.. ..| | | .||.| .
areilnilkvarnsk......slvvhcstGiGrsaafsv.....aElvyqkmirsldttstveldylsLleelrssrkraihtPmqLafsilmvLdfvln
VLASMD
| .
nfakge
|
|||||||||
subfamily_Anemone-PTP-3_pd | Subfamily Anemone-PTP-3 | 86-282 | 9.3e-18 | 59.1 | In-house | 3-198 (199) | alignment | ||
Range on Protein: 86-282
Range on HMM: 3-198/199.0
SQCRFIASQGPLPHTLDDFWRMLWEKDVRIVVMACNIFENDRFKCAKYWPNLHEF-DVFDEFEVDNMAEdAIDQDF----LVRTLKVTHKGASRIIYQYH
.| |.||.| || .|. |||.|.|| .|| . | . ||| . . . | . . |. |. | ..| ..| | .|
gqrryiatqhplretmadfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttkti.ttkpdytitaliltnnttappstreishyq
YHAWPDHGVPARPGSVMrLIAAFRE---RQPSDQAAPLVIHCSAGVGRTGHFLlgticAIDIVWSMLKQmgLDAPCFDIFQVVWFLRQHRPAMVQTEDQY
. .| .. | | .. | || . .. ||...||| | | || |. |.|| .. . |.|.| ||| | .. . ..|
ftswkekttpnvalfvg.fvvasrevskkyeqekdapvivhcsdgqgftgvfv.....aldigvrshee..sktsvvdlfevakrlrqarcgiisslqhy
VFVYK
|.|.
nfiyq
|
|||||||||
subfamily_Nvec-PTP-3_pd | Subfamily Nvec-PTP-3 | 86-282 | 1.1e-17 | 58.9 | In-house | 2-197 (198) | alignment | ||
Range on Protein: 86-282
Range on HMM: 2-197/198.0
SQCRFIASQGPLPHTLDDFWRMLWEKDVRIVVMACNIFENDRFKCAKYWPNLHEF-DVFDEFEVDNMAEdAIDQDF----LVRTLKVTHKGASRIIYQYH
.| |.||.| || .|| |||.|.|| .|| . | . ||| . . . | . . |. |. | ..| ..| | .|
gqrryiatqhplretladfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttkti.ttkpdytitaliltnnttappstreishyq
YHAWPDHGVPARPGSVMrLIAAFRE---RQPSDQAAPLVIHCSAGVGRTGHFLlgticAIDIVWSMLKQmgLDAPCFDIFQVVWFLRQHRPAMVQTEDQY
. .| .. | | .. | || . .. ||...||| | | || |. |.|| .. . |.|.| ||| | .. . ..|
ftswkekttpnvalfvg.fvvasrevskkyeqekdapvivhcsdgqgftgvfv.....aldigvrshee..sktsvvdlfevakrlrqarcgiisslqhy
VFVYK
|.|.
nfiyq
|
|||||||||
subfamily_Cele-PTP-7_pd | Subfamily Cele-PTP-7 | 96-282 | 2.6e-17 | 57.2 | In-house | 99-282 (302) | alignment | ||
Range on Protein: 96-282
Range on HMM: 99-282/302.0
PLPHTLDDFWRMLWEKDVRIVVMACNIFENDRFKCAKYWPN-LHEFDVFDEFEVD------NMAEDAIDQDFLVRTLKVTHKG----ASRIIYQYHYHAW
| ||. .| .. . .| ||| |.. |.. |||.|. . . . | .. | ...| . ..| . |.... . . . .. ||
pkkstlekhwalieqynvaivvqlcsfvedeekkcaeyysdkvggelkfgrytvktvsvktdleeftdkksfklytveiknekkkkkvkktvdilafsaw
PDHGVPARPGSVMRLIaAFRERQpsdqAAPLVIHCSAGVGRTGhfllgTICAIDIVWsmlkQMGLDAPCFDIFQVVWFLRQHRPAMVQTEDQYVFVYK
|||| |. . . . .. | | ...|||||||||| |. || |. . |. ..| .|| | ||.|.| ...
pdhGapkeaytaldil.kfcesy....kknvlvhcsaGvGrtG.....tlvaikyGi....qlcskkkvtdllsivlpvrqcryGavqdeqqliylll
|
|||||||||
subfamily_Fungi-PTP2_pd | Subfamily Fungi-PTP2 | 40-137 | 3e-17 | 57.0 | In-house | 47-156 (349) | alignment | ||
Range on Protein: 40-137
Range on HMM: 47-156/349.0
HTKRKNRYKDIIPYDFNRVVLTTQR----------SEDEDISGSDYINASSV--EHGESQCRFIASQGPLPHTLDDFWRMLWEKDVRIVVMACNIFENDR
.. |||||||.||. ||.| || . ||||| . . . . ..|| | ||| |.|||.... . |..|. . .|..
elfaknrykdilPyehsrvklkkslksskvikastsesdsgklddyinanylkltrisvekkyiatqaPlPstvddfykvillngvklvlsLnddkelsl
FKCAKYWPNL
|| .|| .|
ekcdiywqel
|
|||||||||
subfamily_CG42327_pd | Subfamily CG42327 | 210-286 | 4.8e-14 | 46.7 | In-house | 245-313 (319) | alignment | ||
Range on Protein: 210-286
Range on HMM: 245-313/319.0
DQAAPLVIHCSAGVGRTGhfllgTICAIDIVWSMLKQmglDAPCFDIFQVVWFLRQHRPAMVQTEDQYVFVYKAILD
.. |||.||| |||||| .. | || |.. || |.| ..|. | |.| .|| |.|| .
esqGPlvvhcsdGvGrtG.....lviasdiairslee...skrsvdiPqlvssvrrdrasavltkeqyefiykvlse
|
|||||||||
subfamily_Cele-PTP-17_pd | Subfamily Cele-PTP-17 | 42-124 | 1.9e-13 | 44.6 | In-house | 38-118 (347) | alignment | ||
Range on Protein: 42-124
Range on HMM: 38-118/347.0
KRKNRYKDIIPYDFNRVVLTTQRSEDEDISGS-DYINASSVEHGESQCRFIASQGPLPHTLDDFWRMLWEKDVRIVVmacNIFE
||| || | ||||. ..|. . ||||| . ... .| .| |||.|. |||.|. | || |||
lsknrskdvklidatrvvlspeksknsraddvetyinashikfdnaskeyiltqyplpdtvrdfwkmvsvtkvtqvv...tife
|
|||||||||
subfamily_Fungi-PTP2_pd | Subfamily Fungi-PTP2 | 172-287 | 1.8e-12 | 41.2 | In-house | 216-343 (349) | alignment | ||
Range on Protein: 172-287
Range on HMM: 216-343/349.0
ASRIIYQYHYHAWPDHGVPARPGSVMRLIAA---------FRERQPSDQAAPLVIHCSAGVGRTGhfllgTICAIDIVWSMLK-------QMGLDAPCFD
...| . |.| .. | |... . | .|| ..|..||||| |||| ... .|.. |.|. .. | | .|
kPyellqlqvknwldlslllnPisilqalevkndliddlfarlyldtdqlstllvhcsaGcGrtG.....vlvtldlllsileplqnesnkiklqallkD
-IFQVVWFLRQHRPAMVQTEDQYVFVYKAILDL
|. .| ||. | .||| |....|.|.|
lisiivnelrkqrismvqnlaqfiaiyealLky
|
|||||||||
subfamily_Sponge-PTP4_pd | Subfamily Sponge-PTP4 | 41-145 | 2.3e-12 | 41.0 | In-house | 96-189 (244) | alignment | ||
Range on Protein: 41-145
Range on HMM: 96-189/244.0
TKRKNRYKDIIPYDFNRVVLTTQRsedediSGSDYINASSVEHGESQCRFIASQGPLPHTLDDFWRMLWEKDVRIVVMACNIFENDrfkcaKYWPNLHEF
||| .|.||||| |. | ||||| | . .| .| || | |||.|. |. | ..|. . |.| .|||. .
nswknregaglpfdfnrvplskgs......mgntyinasfvgclgrtaeyiltqhpladtsmdfwkmmlerhvnvlvvlgsveeed.....eywpdsepl
DVFDE
. ..|
ewyee
|
|||||||||
subfamily_eak_pd | Subfamily eak | 27-191 | 2.9e-12 | 40.7 | In-house | 38-196 (332) | alignment | ||
Range on Protein: 27-191
Range on HMM: 38-196/332.0
YKASTSREEGTTMHTKRKNrYKDIIPYDFNRVVLTTQRSEDEdisgsDYINASSVEHGESQCRFIASQGPLPHTLDDFWRMLWEKDVRIVVMACNIFEND
|. | .|.. . . ..| .|.|||.. | ||. . . . ||||| .| | ..| . . . ||.|. |. .|. . |..
yqrllsisetarleavnrn.vvkivpydrylvrltssqlnrl.....GyinaslaefsevGrkyiltGiasedkvfafwqmvleqkspaivqlledvelk
RFKCAKYWPNLH-EFDVFDEFEVDNMAEdaIDQD-FLVRTLKVTHKGASRIIYQYHYHAWPDHGVPA
| ||.|. | | ..|. . .. . .| |... . .. |... | . .|
leksdkyfpdktreelkfGildverkef..vkrniletrllelskGnethrvlhykvfGwtettlpk
|
|||||||||
subfamily_Sponge-PTP-7_pd | Subfamily Sponge-PTP-7 | 215-286 | 7.1e-11 | 36.3 | In-house | 1-63 (69) | alignment | ||
Range on Protein: 215-286
Range on HMM: 1-63/69.0
LVIHCSAGVGRTGHFLlgticAIDIVWSMLKQMGLdapcFDIFQVVWFLRQHRPAMVQTEDQYVFVYKAILD
.|.|||.| |||| |. || . . .| | ||| | ..|. || || | .|.|.. |. .
mvvhcssgtgrtgtfi.....aimvemariksekl....vdifnnvqymrkcrpmmvmneieyifihdalve
|
|||||||||
subfamily_Choan-PTP-4_pd | Subfamily Choan-PTP-4 | 201-288 | 1.5e-10 | 35.4 | In-house | 219-295 (297) | alignment | ||
Range on Protein: 201-288
Range on HMM: 219-295/297.0
AAFRERQPsdQAAPLVIHCSAGVGRTGHFLLGticaiDIVWSMLKQMGLdaPcfDIFQVVWFLRQHRPAMVQTEDQYVFVYKAILDLV
..| .| . |.|..||||||||.| .| |.. ..|.. . | |. .. .||. |. .||| .|. ..|.|.| .
eslraemp..rnayllvhcsaGvGrsGvvvls.....dvilaklrkkri..p..dvaailsilreqrarlvqtleqfellydavlkkl
|
|||||||||
subfamily_Sponge-PTP7_pd | Subfamily Sponge-PTP7 | 216-286 | 2.5e-10 | 34.6 | In-house | 1-62 (69) | alignment | ||
Range on Protein: 216-286
Range on HMM: 1-62/69.0
VIHCSAGVGRTGHFLlgticAIDIVWSMLKQMGLdapcFDIFQVVWFLRQHRPAMVQTEDQYVFVYKAILD
|.|||.| |||| |. || . . .| | ||| | ..|. || || |..|.|.. |. .
vvhcssGtGrtGtfi.....aimvemariksekl....vdifnnvqymrkcrpmmvmneneymfihdalve
|
|||||||||
subfamily_Sponge-PTP-4_pd | Subfamily Sponge-PTP-4 | 51-145 | 1.3e-09 | 32.5 | In-house | 3-80 (130) | alignment | ||
Range on Protein: 51-145
Range on HMM: 3-80/130.0
IPYDFNRVVlttqrsededisGSDYINASSVEHGESQCRFIASQGPLPHTLDDFWRMLWEKDVRIVVMACNIFENDrfkcaKYWPNLHEFDVFDE
......|. | .||||| | . .. .| || | |||.|. |. | ..|. . |.| .|||. .. ..|
lefevsrlq............gntyinasfvGllgrtaeylltqhpladtsmdfwkmmleryvnvlvvlgsveeed.....eywpdsePlewyee
|
|||||||||
0038934 | (Phosphotyrosine protein) phosphatases II | 160-283 | 6.9e-09 | 31.1 | In-house | 45-172 (194) | alignment | ||
Range on Protein: 160-283
Range on HMM: 45-172/194.0
FLVRTLKVTHKGASRII------------------YQYHYHAWPDHGVPARPGSVMRLIAAFRERQPSDQAAPLVIHCSAGVGRTGHFllgticaidIVW
.||| || ... .| ..|. .||.|.. ..| . . | |. ..|| ||.|||| . ..
dlvrylkllnvklglvidltnteryYdpeefekagieylklpfpddgtvPsleillrfldlvdeflnedpggvvaVHCkaGlgRtGtl.........vaa
SMLKQMgldapCFDIFQVVWFLRQHRPAMVQTEDQYVFVYKA
... . ... . . ..|. || .... |.. ..|
YLiyrl.....gmsaeeAialfrekRpgaipnqdyleallkr
|
|||||||||
subfamily_Sponge-PTP3_pd | Subfamily Sponge-PTP3 | 34-95 | 1.5e-08 | 28.7 | In-house | 41-95 (95) | alignment | ||
Range on Protein: 34-95
Range on HMM: 41-95/95.0
EEGTTMHTKRKNRYKDIIPYDFNRVVLTTQRSededisgSDYINASSVEHGESQCRFIASQG
|.. |||. .|.||| ||||||.| |||||| |. . .||.||
tvgsseanipknrflnifpydatrvvlttkrd.......sdyinacfvdgyarkncyiaaqg
|
|||||||||
subfamily_Cele-PTP-5_pd | Subfamily Cele-PTP-5 | 101-289 | 1.4e-07 | 24.5 | In-house | 131-310 (346) | alignment | ||
Range on Protein: 101-289
Range on HMM: 131-310/346.0
LDDFWRMLWEKDVRIVVMACNIFENDRFKCAKYWPNLHEFDVFDEFEVDNMAEDaIDQDFLVRTLKVTHKGAS-RIIYQYHYHA-WPDHGVPARPGSVMR
..||| |........| . . . . .. . ..| | . | |..| .| | .| | |.|| | | . ...
vedfwymiyqeqihlvylmvpddklkntttslfndenggyqytgkmfinnrrad.vsgdpkeytievlpegnsdsvicqvhhhapwkhlqqppktlpiik
LIAAFRERQPSdQAAPLVIHCSAGVGRTGHFlLGTICAIDIVwsmlkQMGLDApcfDIFQVVWFLRQHRPAMVQTEDQYVFVYKAILDLVQ
.| | . |.| . . | ||. | .|.. ||. . . |.. .|.... ..| || |.. || .| ..| .
mihqflsekqv.qnagvcvvslfgcgracsf.igalyainql.....nngiep...niceimknikqqrpggvesfaqyasiyaivfdyia
|
|||||||||
subfamily_ptpA1_pd | Subfamily ptpA1 | 254-292 | 1.7e-07 | 25.3 | In-house | 364-402 (418) | alignment | ||
Range on Protein: 254-292
Range on HMM: 364-402/418.0
FDIFQVVWFLRQHRPAMVQTEDQYVFVYKAILDLVQQVL
|..| .| ||..|| ||| .||.|.||.||| . . |
fnlfsivlklreqrpgmvqqleqylfcyktildeiyhrl
|
|||||||||
subfamily_Sponge-PTP-2_pd | Subfamily Sponge-PTP-2 | 44-199 | 3.5e-07 | 23.3 | In-house | 30-164 (169) | alignment | ||
Range on Protein: 44-199
Range on HMM: 30-164/169.0
KNRYKDIIPYDFNRVVLttQRSEdEDIsGSDYINAssvehgesqcrfiasqgplphtlddfwRMLWEKDVRIVVMACNIFENDRFKCAKYWPNLHEFDVF
||| . . || | || ||. ||||||| ||.|| . ..|. . . . | | .|| ..
knrpagplapshtrvkl..qrvm.edl.gsdyina...........................rmiwetnasvivvlgdtddknnfwpekedyqlhpavil
DEFEVDNMA--EDAIDQD-----FLVRTLKVTHKGASRII---YQYHYHAWPDHGVPARPGSVMRL
|. | . | ... |. | |. . . .|| .||. ||| | | .|
gewytdslyvrtdkvhantsgveglfevsmvihsydddvteklsllhystwpqngvpqspvhvghl
|
|||||||||
subfamily_Urchin-PTP-2_pd | Subfamily Urchin-PTP-2 | 88-170 | 4.4e-07 | 23.6 | In-house | 236-314 (440) | alignment | ||
Range on Protein: 88-170
Range on HMM: 236-314/440.0
CRFIASQGPLPHTLDDFWRMLWEKDVRIVVMACNIfeNDRfKCAKYWPNLHEFDVFDEFEVDNMAEDAIDQdFLVRTLKVTHK
|||.| || |. ||||.. . . ..| .. ||. |. ||| | | | . ... ||||.. .|
nafiatqmpldstvldfwrlvhdyristiimlnql..ndk.tcsiywpvntrsvtfgpftvghkgsenmnr.vkvrtlelkyk
|
|||||||||
subfamily_Sponge-PTP2_pd | Subfamily Sponge-PTP2 | 44-199 | 6.4e-07 | 22.3 | In-house | 29-163 (169) | alignment | ||
Range on Protein: 44-199
Range on HMM: 29-163/169.0
KNRYKDIIPYDFNRVVLttQRSEdEDIsGSDYINAssvehgesqcrfiasqgplphtlddfwRMLWEKDVRIVVMACNIFENDRFKCAKYWPNLHEFDVF
||| . . || | || ||. ||||||| ||.|| . ..|. . . . | | .|| ..
knrpagplapshtrvkl..qrvm.edl.gsdyina...........................rmiwetnasvivvlGdtddknnfwpekedyqlhpavil
DEFEVDNM--AEDAID-----QDFLVRTLKVTHKGASRIIY---QYHYHAWPDHGVPARPGSVMRL
|. | . | .. . |. | |. . . .|| .||. ||| | | .|
Gewytdslyvrtdkvhpntsgveglfevslvihsydddvteqlsllhystwpqngvpqspvhvghl
|