Gene PTPN23 in Monosiga brevicollis

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily PTPN23
Protein sequence
ID Type Fasta BLAST phosphatome Note
MbreP066_AA protein Get Run
MbreP066_AA_829-1152 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_PTPN23_pd Subfamily PTPN23 831-1159 4e-136 447.5 In-house 2-288 (288) alignment
Range on Protein: 831-1159
Range on HMM: 2-288/288.0
TVAHLQQAYPDGKSGFDKEFALLEMEDAAHNRDTSCAAAERNVDRNRYRDILPYDRTRVHMQvlpgyGSTDDYINACHVRSLTSGCPDFVCAQGPKHSTS
.|..||....|||...||.|..||.......|..|.|.|......||.|||||||..||...     ||.||||||..|..|..|||||...|.|..||.
lveelqrkmldgktaldkkfkeleqkqdkearkrsiaiaklyseknrsrdilPyDhnRvklr.....gskDDYinAsfvkdlspgcPdfiatqaPlqstl

GDFWKMVVQQRSRVIVMVTNLEERGRPKCDRYWPARCGETVSHPEtalglaLDVTLKEERETGPWIERDLIVETLRPDHTKMVRHVkqfHYTSWPDHGVP
.|||.||..|.|.||||... ||.|.||.|||||...||||....      |.||||..|||....||.|..|||..|..|.|.|.   ..||||..|||
nDFWlmvyeqkssviVmllskeelgkpkvdrYwPedkgetvkfgd......lsvtlksvretethvervlkletldadavksvshl...qltsWpelGvP

ASPETFLEFLLAVKQHHDAVQRQSQTagepqsPLVVHCSAGVGRTGTFCCVYGVVAALpYVGNGLPllaaresgaqrptresqggklDIMNIVSRMREDR
|||||.|.|| .|.....||||.|.|      ||||||||||||||.|..||..|..| ..||||.                     ||...|||.||.|
asPetllqfldevesayeavqrkskt......PlvvhCsaGvgRtgvfalvyaavrel.ekgngll.....................diiqvvsrlreqR

RFMVQTVDQYKFCYLASLEAARRYNDKYG
|||||...|.||.| |.||||||..||.|
rfmvqekeqlkfsyeavleaarrvldkrG

0051299 (Phosphotyrosine protein) phosphatases II 829-1149 2.4e-82 271.9 In-house 8-284 (288) alignment
Range on Protein: 829-1149
Range on HMM: 8-284/288.0
SETVAHLQQAYPDGKSGFDKEFALLEMEDAAhnRDTSCAAAERNVDRNRYRDILPYDRTRVHMQVLPGyGSTDDYINACHVRSlTSGCPDFVCAQGPKHS
.| . .... ...|..|. .||  |    .   ...|.|. . |...|||.||||||..||...||.|  ...||||| ...        |...|||...
eellklvlkllangltglleefeellsllpd..ltlsaallpenleknRysdilpydhsRVkLsvldg.vegsdYinAsyidg.ynlkrkfIatqgPlpn

TSGDFWKMVVQQRSRVIVMVTNLEERGRPKCDRYWPArcGETVSHPEtalglaLDVTLKEERETGPWIERDLIVETLR-PDHTKMVRHVKQFHYTSWPDH
| .|||.|| .|..|||||.|.|.|.|| ||..|||   |... . .      . |||..| . . .. | |.|. |. .| .. .|.|..||||.||||
tvedFWrmvweqnvrvIvmltklvelgrekcaqYwpl..ggsltygd......itvtllseevlddytvrtlevtnldlldgdgesrtvthfhytnwpdh

GVPASPETFLEFLLAVKQHHDavqrqsqtagEPQSPLVVHCSAGVGRTGTFCCVYGVVAALPyvgnglpllaaresgaqrptresQGGKLDIMNIVSRMR
||| ||| .|.|| .|....            ...| ||||||||||||||.... ..  |                        ..|..|....| |.|
gvpdspellldflrlvrkala..........sgggpvvVHCsaGvgRtgtfialdllleqle.......................keggvdvleavkrlr

EDRRFMVQTVDQYKFCYLASLE
| | .||||..||.|.| | ||
eqRpgmvqtpeqyrfvyealle

0050432 (Phosphotyrosine protein) phosphatases II 836-1154 7e-81 267.2 In-house 36-302 (308) alignment
Range on Protein: 836-1154
Range on HMM: 36-302/308.0
QQayPDGKSGFDKEFALLEMEDAahNRDTSCAAAERNVDRNRYRDILPYDRTRVHMqvlpgyGSTDDYINACHVRSLT-SGCPDFVCAQGPKHSTSGDFW
..  .........||  | .     ....|.|. ..|.|.|||.||||||..||..      ....||||| .|.  .      |...|||...| .|||
ek..aldlglleeefeellsvkp..lleysvallpenkdkNrykdilpydhsRVkl......degsdYInAsyvdgyssklprkfIatqgPlpntvedFw

KMVVQQRSRVIVMVTNLEERGRPKCDRYWPARCG-ETVSHPetalglALDVTLKEERETGPWIERDLIVETLRPDHTkmvRHVKQFHYTSWPDHGVPASP
.|| .|..|||||.|.|.|.||.||..|||   | ... .        . |||..| . . .. | |... |. . .   |.|..||||.||||||| ||
rmvweqnvrvIvmLtklvengrekcaqYwplelgggsleyg......kftvtllseevlddytvrtleltnlgdges...rtvthfhytnWpdhgvPpsp

ETFLEFLLAVKQHHdavqrqsqtagePQSPLVVHCSAGVGRTGTFCCVYGVVAALPYvgnglpllaaresgaqrptresqGGKLDIMNIVSRMREDRRFM
| .|.|| .|....            |..| ||||||||||||||.... ..  | .                       .|..|. ..| ..|| | .|
eilldflelvrksl............pggpivVHCsaGvGRtGtfialdllleqlek.......................eggvdvfeavkklReqRpgm

VQTVDQYKFCYLASLEAARRY
|||..||.|.| | || ....
vqtpeqylflyralleylklk

0046845 (Phosphotyrosine protein) phosphatases II 845-1155 1.1e-80 266.4 In-house 1-278 (284) alignment
Range on Protein: 845-1155
Range on HMM: 1-278/284.0
GFDKEFALLEMEDAAHNRDTSCAAAERNVDRNRYRDILPYDRTRVHMQVLPGYGSTDDYINACHVRSLT----SGCPDFVCAQGPKHSTSGDFWKMVVQQ
|...||  | .    .  ..|.|... |...|||.||||||..||....|.|  ...||||| .|.         .. |...|||. .| .|||.|| .|
gleeefeellsltvklllslsvallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweq

RSRVIVMVTNLEERGRPKCDRYWPARcGETVSHPEtalglaLDVTLKEERETGPWIERDLIVETLrpDHTKMVRHVKQFHYTSWPDHGVPASPETFLEFL
..|||||.|.|.|.|| ||..|||   ||.. . .      . |||..| . . .. | | .. |  . |. .|.|..||||||||||||.||| .||||
nvrvIVmltelvengrekcaqYwple.gevltygd......ftvtllseevkddytvrtleltnl..gytgesrtvthfhytswpdhgvppspedllefl

LAVKQHHDAvqrqsqtaGEPQSPLVVHCSAGVGRTGTFCCVYGVVAALPYVgnglpllaaresgaqrptresqgG---KLDIMNIVSRMREDRRFMVQTV
 .|......         ....| ||||||||||||||.... .   | .                        |   ..|. ..|.|.|| | .||||.
rlvrellen........lpgggpivVHCsaGvgRtGtfialdllleqleke.......................glllgvdvleavkrlreqRpgmvqtl

DQYKFCYLASLEAARRYN
.||.|.| | ||......
eqyrfvyealleylklkl

0045450 (Phosphotyrosine protein) phosphatases II 832-1149 5.4e-76 251.6 In-house 15-302 (307) alignment
Range on Protein: 832-1149
Range on HMM: 15-302/307.0
VAHLQQAYPDGKSGFDKEFALLEMEDAAHNRDTSCAAAERNVDRNRYRDILPYDRTRVHMQVLPGYGSTDDYINACHVRSLT-------SGCPDFVCAQG
. ....  .|...|. |||  |  .   .. ..|.|. . | |.|||.||||||.|||....|.|  ...||||| .||            .  |...||
lllvllllldfltgllkefekllsvtvfllgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydlkrkfIatqg

PKHSTSGDFWKMVVQQRSRVIVMVTNLEERGRPKCDRYWPARcGETVSHPEtalglaLDVTLKEERETGPWIERDLIVETLrpDHTKMVRHVKQFHYTSW
|...|  |||.|. .|...||||.|.|.|.||.||..|||   ||.. . .      . |||..| . . .. | | |. |  | |...|.|..||||.|
PlpetvedFwrmlweqgvtvivmltelvelgrekcaqywPde.geeltygn......ftvtllseehldgytvrtlevtdl..dgtgesrtvthfhytgw

PDHGVPASPETFLEFLLAVKQHHDAvqrqsqtaGEPQSPLVVHCSAGVGRTGTFCCVYGVVAALPYVgnglpllaaresgaqrptresqgGK---LDIMN
|||||| |.|..|.|. .|......          ...| .|||||||||||||.. | .   | .                        |.   .|. .
pdhgvppsfeelldfieevrkalee........lpkggpvlVHCsaGvgRtGtfiaaylmlrqleke.......................gtlldvdlle

IVSRMREDRRFMVQTVDQYKFCYLASLE
.|...|| |  .||. .||.|.| | ||
avkllreqRpgavqnpeqyrflyealle

0047943 (Phosphotyrosine protein) phosphatases II 840-1149 5.8e-75 247.6 In-house 8-270 (273) alignment
Range on Protein: 840-1149
Range on HMM: 8-270/273.0
PDGKSGFDKEFALLemEDAAHNRDTSCAAAERNVDRNRYRDILPYDRTRVHMqvlpgYGSTDDYINACHVrSLTSGCPDFVCAQGPKHSTSGDFWKMVVQ
..|.... .|| ||   .  .. ..|.|. ..| |.|||.||||||..||..      ....||||| .| ..    . |...|||. .| .|||.|| .
llgltllleefell..lslkplltysvallpenkdknrykdilpydhsrvkl.....gdggsdyinAsyv.dgynlkrkfiatqgPlpntvedfwrmvwe

QRSRVIVMVTNLEERGRPKCDRYWPARCGE-TVSHPEtalglaLDVTLKEERETGPWIERDLIVETLRPDHtkmVRHVKQFHYTSWPDHGVPASPETFLE
|..|||||.|.|.|.||.||..|||   || .. . .      . |||..| . . .. | |... |  ..   .|.|..||||.|||||||.|.| .||
qnvrviVmLtelvelgrekcaqYwpleggelsltygk......ftvtllseetkddytvrtleltnlgtge...srtvthfhytgwpdhgvppsleslle

FLLAVKQHHDAVQRQsqtagepqSPLVVHCSAGVGRTGTFCCVYGVVAALPYvgnglpllaaresgaqrptresqGGKLDIMNIVSRMREDRRFMVQTVD
|. .|.... |. ..        .| ||||||||||||||.... ..  | .                       .|..|. ..| ..|. |  ||||..
fielvrkalealpsn........gpvvVHCsaGvgRtgtfialdllldqlek.......................eggvdvleavkllrsqRpgmvqtpe

QYKFCYLASLE
||.|.| | ||
qyrflyealle

0039614 (Phosphotyrosine protein) phosphatases II 829-1155 1.1e-74 246.9 In-house 17-293 (297) alignment
Range on Protein: 829-1155
Range on HMM: 17-293/297.0
SETVAHLQQAYPDGKSGFDKEFALLEMEDAahnrDTSCAAAERNVDRNRYRDILPYDRTRVHMQVLPGYGSTDDYINACHVRSLTSGCPDFVCAQGPKHS
|   ..|.   ...|.....||  |         |.|.|. . |.|.|||.||||||..||. ....|.   .||||| .|      ...|...||| ..
svldlllllekansktllllefeellslkp....dysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfIatqgPlpe

TSGDFWKMVVQQRSRVIVMVTNLEERGRpKCDRYWPARCGetvS--HpetalglaLDVTLKEERETGPWIERDLIVETlrpdhTKMVRHVKQFHYTSWPD
| .|||.|| .|...||||.|.|.|.|| ||..||| . |      .        . |||... . . .. | | |.      .. .|.|..|.||.|||
tvedFwrmvweqgvtvivmLtklvelgr.kcaqywpeegg...tygd........ftvtllkvehldgytvrtlevtn.....ngesrtvthfqytgwpd

HGVPASPETFLEFLLAVKQHHDAVqrqsqtagEPQSPLVVHCSAGVGRTGTFCCVYGVVAALPyvgnglpllaaresgaqrptresQGGKLDIMNIVSRM
|||| |.|..|||| .|.... .         ... | .|||||||||||||.. | ..  |                         .|..|. ..|...
hgvppslellleflelvrealael........pkggpvlVHCsaGvgRtGtfiaaylmleqle.......................keggvdvleavkel

REDRRFMVQTVDQYKFCYLASLEAARRYN
|| |. .||| .||.|.| | ||  .|..
reqRpgavqtpsqyrflydallellkrkl

0040438 (Phosphotyrosine protein) phosphatases II 834-1155 4e-74 245.0 In-house 8-280 (317) alignment
Range on Protein: 834-1155
Range on HMM: 8-280/317.0
HLQQAYPDGKSGFDKEFALLEMEDAAhnrDTSCAAAERNVDRNRYRDILPYDRTRVHMQVLPGyGSTDDYINACHVrSLTSGCPDFVCAQGPKHSTSGDF
.|.. .. .. .. .||  |   .     ..|.|. . | |.|||.||||||..||....|.|    .||||| .| .  . .. |...|||. .| .||
alldllksdftalleefedllslkld...tysvaelpenkdknrypdilpydhsRVkLsplgg.dldsdYInAsyv.dgpnlkrkfIatqgPlpntvedF

WKMVVQQRSRVIVMVTNLEERGRPKCDRYWPArcGETVSHPEtalglaLDVTLKEERETGPWIERDLIVETLrpdHTKMVRHVKQFHYTSWPDHGVPASP
|.|| .|...||||.|.|||.||.||..|||   |||. . .      . |||..| | . .. | | || |    .. .|.|..||||.||||||| ||
wrmvweqgvtvivmLteleelgrekcaqYwpl..getltygd......ftvtllseeelagitlrtlevedl...gdsesrtvthfhytgWpdhgvppsp

ETFLEFLLAVKQHHdavqrqSqtagEPQSPLVVHCSAGVGRTGTFCCVYGVVAALPyvgnglpllaaresgaqrptresQGGKLDIMNIVSRMREDRRFM
...|.|| ||...       .    .|..|..|||||||||||||...| ..  |                        ..|..|. ..| ..|| |. .
dllldfleavreal......e....dpggpvlVHCsaGvgRtGtfiaaylmleqle.......................keggvdveeavkelreqRpga

VQTVDQYKFCYLASLEAARRYN
||| .||.|.| | ||  .|..
vqtpeqyrflydalleylkrkl

0036941 (Phosphotyrosine protein) phosphatases II 842-1155 4.3e-74 244.8 In-house 11-281 (297) alignment
Range on Protein: 842-1155
Range on HMM: 11-281/297.0
GKSGFDKEFALLemEDAAHNRDTSCAAAERNVDRNRYRDILPYDRTRVHMqvlpgYGSTDDYINACHVrSLTSGCPDFVCAQGPKHSTSGDFWKMVVQQR
..... |||  |   .  .. ..|.|. ..|...|||.||||||.|||..      .. .|||||..| .. . .  |...|||...| .|||.|| .|.
flalllkefeel..lpllllgslsvallpenleknRykdilpydhtRVkl.....ddegsdYinAsyv.dgydlkrkfIatqgPlpntvedFWrmvweqn

SRVIVMVTNLEERGRPKCDRYWPARCGETVSHPEtalglaLDVTLKEERE--TGPWIERDLIVETLrpdHTKMVRHVKQFHYTSWPDHGVPASPETFLEF
..||||.|.|.|.||.||..|||   ||.. . .      . |||... .   . .. | | |. .    .. .|.|..||||.||||||| ||...|.|
vtvIvmltelvelgrekcaqywpleegesltygd......ftvtllsvevvllddytlrtlevtdt...gngesrtvthfhytgwpdhgvpespaslldf

LLAVKQHHDAVqrqsqtagEPQSPLVVHCSAGVGRTGTFCCVYGVVaalpyvgnglpllaaresgaQRPTRESQGGKLDIMNIVSRMREDRRFMVQTVDQ
. .|......          ...| .|||||||||.|||.... ..                    |.  ..   |..|| ..|  .|| | ..|||..|
ielvrkvlkll........psggpvlVHCsaGvgRsgtfiaadlml....................qqledklkeggvdileavkklReqRpgavqtleq

YKFCYLASLEAARRYN
|.|.| | ||  ....
yrflyeallellkkkl

0043336 (Phosphotyrosine protein) phosphatases II 830-1148 6e-72 237.7 In-house 6-274 (278) alignment
Range on Protein: 830-1148
Range on HMM: 6-274/278.0
ETVAHLQQAYPDGKSGFDKEFALLEMEDAahnRDTSCAAAERNVDRNRYRDILPYDRTRVHMQVLPGyGSTDDYINACHVrSLTSGCPDFVCAQGPKHST
. . .|.. ....|... .||  |   .     ..|.|. . |.|.|||.||||||..||....|.|    .||||| .| .. . ...|...||| ..|
dllkallelllnlktllllefeellsfkl...dtysiallpenkdknrykdilpydhsrvklsllgg.dldsdYinAsyv.dgynvprkfiatqgPlpet

SGDFWKMVVQQRSRVIVMVTNLEERGRPKCDRYWParcGETVSHPEtalglaLDVTLKEERETGPWIERDLIVETLRPDHTkmvRHVKQFHYTSWPDHGV
 .|||.|| ......|||.|.|.|.||.||..|||   |... . .      . |||..| . . .. |.| |. |. . .   |.| ..||..||||||
vedFwrmvwelgvttivmLtelvelgrvkcaqYwp...ggsltygd......ftvtllkeehlddytvrtlevtnlgdges...rtvthyhylgwpdhgv

PASPETFLEFLLAVKQHHDavqrqsqtagEPQSPLVVHCSAGVGRTGTFCCVYGVVAALPYvgnglpllaaresgaqrptresqGGKLDIMNIVSRMRED
| |....|.|| ||... .           ...|..|||||||||||||...| ..  | .                       .|..|. ..|...|| 
peslsllldflkavreale..........dsngpvlVHCsaGvgRTGtfialyllleqlek.......................eggvdleeavkelreq

RRFMVQTVDQYKFCYLASL
|  .||| .||.|.| | |
Rpgavqtpsqyrflyeall

DSPc_SM00195 846-1150 4.6e-71 234.6 In-house 2-261 (263) alignment
Range on Protein: 846-1150
Range on HMM: 2-261/263.0
FDKEFALLEMEDAAHnrDTSCAAAERNVDRNRYRDILPYDRTRVHMQVLPGYgSTDDYINACHVRSLtSGCPDFVCAQGPKHSTSGDFWKMVVQQRSRVI
...||  ||...  .  .|..|. ..|...|||..|||||.|||...  ..  ...||||| ...   .   .....|||. ||  |||.||.......|
lkeefekleestspk..etteaekkknksknRyknilpydhtrVklkkeekk.egsdYINAnyikga.nkkkkyIatQgPlpstvedFWrmvweekvkii

VMVTNLEERGRPKCDRYWPARCGETVSHPetalglALDVTLKEERETGpwieRDLIVETLRPDHTK--MVRHVKQFHYTSWPDHGVPASPETFLEFLLAV
||.|. ||.|. |||||||   |..  .        . |.|.|. ..     ...|..||.  ...    | |.|..|..||||||| |.. .||.| ||
vmlteeeengkekcdrywpeesggketfg......kisvklvevekkk....deiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellrav

KQHHDAVqrqsqtagepQSPLVVHCSAGVGRTGTFCCVYGVVAALPYVGNglpllaaresgaqrptresqggkLDIMNIVSRMREDRRFMVQTVDQYKFC
|....            ..|.||||||||||||||...  ..  |    .                       .|| .||...|. |  |||| .||.|.
kksksts..........sgpivVhCsaGvgRtgtfvtidiilskleeekk.......................vdifeivkelRkqRpgmvqtleqYlfi

YLASLEA
| | ||.
yeailey

PTPc_SM00194 846-1150 4.6e-71 234.6 In-house 2-261 (263) alignment
Range on Protein: 846-1150
Range on HMM: 2-261/263.0
FDKEFALLEMEDAAHnrDTSCAAAERNVDRNRYRDILPYDRTRVHMQVLPGYgSTDDYINACHVRSLtSGCPDFVCAQGPKHSTSGDFWKMVVQQRSRVI
...||  ||...  .  .|..|. ..|...|||..|||||.|||...  ..  ...||||| ...   .   .....|||. ||  |||.||.......|
lkeefekleestspk..etteaekkknksknRyknilpydhtrVklkkeekk.egsdYINAnyikga.nkkkkyIatQgPlpstvedFWrmvweekvkii

VMVTNLEERGRPKCDRYWPARCGETVSHPetalglALDVTLKEERETGpwieRDLIVETLRPDHTK--MVRHVKQFHYTSWPDHGVPASPETFLEFLLAV
||.|. ||.|. |||||||   |..  .        . |.|.|. ..     ...|..||.  ...    | |.|..|..||||||| |.. .||.| ||
vmlteeeengkekcdrywpeesggketfg......kisvklvevekkk....deiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellrav

KQHHDAVqrqsqtagepQSPLVVHCSAGVGRTGTFCCVYGVVAALPYVGNglpllaaresgaqrptresqggkLDIMNIVSRMREDRRFMVQTVDQYKFC
|....            ..|.||||||||||||||...  ..  |    .                       .|| .||...|. |  |||| .||.|.
kksksts..........sgpivVhCsaGvgRtgtfvtidiilskleeekk.......................vdifeivkelRkqRpgmvqtleqYlfi

YLASLEA
| | ||.
yeailey

subfamily_PTPRD_pd Subfamily PTPRD 832-1081 8.4e-69 227.7 In-house 11-234 (564) alignment
Range on Protein: 832-1081
Range on HMM: 11-234/564.0
VAHLQQAYPDGKSGFDKEFALLEMEdaaHNRDTSCAAAERNVDRNRYRDILPYDRTRVHMQVLPGYgSTDDYINACHVRSLTsGCPDFVCAQGPKHSTSG
 .|...   ...  |..|.  .|..   ..  .. |... |  .||| .|..||..|| .. ..|  .  ||||| .. . .     .. .|||...|  
kehvaklkansdlkfeeeykkieeg...qqftweaankpaNkaKNRyanivaYdhsRVvLskvegd.egsDYINAsfidgyr.krkayIAtqgPlaetie

DFWKMVVQQRSRVIVMVTNLEERGRPKCDRYWPARcGeTVSHPEtalglaLDVTLKEERETGPWIERDLIVETLRpdhTKMVRHVKQFHYTSWPDHGVPA
|||.|| .|.|..|||.|.|||.|. ||..|||.. | | .. |      | |||.|| |    . |...... .   .. .| |.|||.||||||||| 
dFWRmvweqnsstiVmltkleEkgkvkchkYWPek.g.tetyge......ltVtleeeeeladyeirtfklkkkk...ssesreVrqFhFtsWPdhgvpe

SPETFLEFLLAVKQHHDavqrqsqtagEPQSPLVVHCSAGVGRTGTFCCV
|....|...  |....           . . |.||||||||||||||. .
satslLdlirkvralne..........pdagPivVhCSaGVGRTGtfivi

0040439 (Phosphotyrosine protein) phosphatases II 863-1149 1.1e-66 220.2 In-house 2-244 (249) alignment
Range on Protein: 863-1149
Range on HMM: 2-244/249.0
DTSCAAAERNVDRNRYRDILPYDRTRVHMQVLPGyGSTDDYINACHVrSLTSGCPDFVCAQGPKHSTSGDFWKMVVQQRSRVIVMVTNLEERGRPKCDRY
..|.|  . |.|.|||.||||||..||....||| .  .||||| .. ...  ...|...||| ..| .|||.|. .....||||.|.|.|.|| ||..|
eysvallpenkdknrypdilpydhsrvklsilpg.lflsdyinAsyi.dgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqy

WPArcGETVSHPEtalglaLDVTLKEERETGPWIERDLIVETLrpdHTKMVRHVKQFHYTSWPDHGVPASPETFLEFLLAVKQHHDAVqrqsqtagEPQS
||   |... . .      . |||... . . .. | | .. |    .. .|.|....||.||||||| |.|..|.|. ||......         ....
wpl..ggsleygd......ftvtllsvevkddytvrtleltnl...ydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleel........pkgg

PLVVHCSAGVGRTGTFCCVYGVVAALPYvgnglpllaaresgaqrptresqGGKLDIMNIVSRMREDRRFMVQTVDQYKFCYLASLE
|..|||||||||||||.. | ..  | .                        ...|. ..|. .|. |. .||. .||.|.| | ||
pvlVHCsaGvgRtGtfiaaylmleqlek.......................elgvdleeavkllrsqRpgavqnpeqyrflyealle

subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 830-1148 8.4e-66 216.9 In-house 7-276 (288) alignment
Range on Protein: 830-1148
Range on HMM: 7-276/288.0
ETVAHLQQAYPDGKSGFDKEFALLemEDAAHNRDTSCAAAERNVDRNRYRDILPYDRTRVHMQVLPGyGSTDDYINACHVRSLTSgCPDFVCAQGPKHST
. ||. ...  ....|| .|.  |      ...... .   .| ..||||.||||| .||... |.  ... ||||| .. .  .    ....|||  .|
spvakvakksarnrtgfseeynsL..aalektksvtagrlavnakknRyrnilpyDekrvklkklee.eagaDYinasyidgekk.kkkyiatqgPladt

SGDFWKMVVQQRSRVIVMVTNLEERGRPKCDRYWPARcGETVSHPEtalglaLDVTLKEERETGPWIERDLIVEtlrpdHTKMVRHVKQFHYTSWPDHGV
 .|||..| ....  |||.|.| |.|. ||..|||.  .. . . .      ..|||.|..|.. ...| |..|     ..|  ....|..|..||||||
vndfWelvyenktstivmltelveggktkCeeYWPda.dkpknyGs......vtvtlveskeledfvlrkllle.....kkkteleitqyqylaWpdhgv

PASPETFLEFLLAVKQHHDAVqrqsqtagepQSPLVVHCSAGVGRTGTFCCVYGVVAALPYvgnglpllaaresgaqrptresqGGKLDIMNIVSRMRED
|.| . .||.|  ||. ..|           . |..|||||||||||||  .  .. |.                           ..|....|...|. 
Peskapllellrqvkvanqad..........tgpiivhCsaGvGrtgtFialdalidavee.......................edyiDvagtvaklRkq

RRFMVQTVDQYKFCYLASL
| ..|||. || |.| . |
RallvqtlkqYefiyevll

BRO1 BRO1-like domain 53-426 1.3e-65 209.9 Pfam-A 2-376 (377) alignment
Range on Protein: 53-426
Range on HMM: 2-376/377.0
FLAASVKTAQPCAIEDTLIKFISQTLEQPGEDYRVELQQLRNLRATLHTG-HVDQQYLANARLYAAQLHFAKSRFYagSTTPQLDFSWLDTF-TKSFVSS
...  .| .... . . | ..|..| ... . |. .|..|..|| .. |  . |.. |..   | |||.. ..||   .   ...|.| |.| |.| ...
lislplKetkevdlskpLsdyIletygeesssyeddlaelnklRqaavtpssrdesglelllrYyaqLellekrfp..drslkveFtWydafdtgsplaq

HALAHEYGSVLFNIAGAAGRLASLEfagADSSDDTLKTCLQMQQLSVAAIMAVQQQeLGDTPSHDMHAAALDVLLHVYTAQSYQCSLYKALHSNMKATTI
..|| |  |||||.|  . ..|. .     |||. ||.  .. | .  |   .... . ..|| |.... |.|| ... || ..| | ||.....|...|
rslafEkasvlFnlaalysqiaasq...nrssdeglkaAvkyfqrAaGafeylken.flhapseDlspetlkvlvklmlAqAqecflekaildkkkdsli

ARIAIRVANEFDAAHKALYSIETNKDHPwHLWQLCVQLKSMHARGLAQFYQGQAANKASEWGEEVGRLRAARDVLQAAIETAKA-VKNAVDVAAIQHTLN
|..|  ||.... |..|| . .|... |   |.  ||.|... . ||..||..|...... ||...||..| ..|. |...||.  ..     ... . .
aklaaqvadlYeealealqesptktgip.kewaklvqvKaeyfkAlahyyqalaleekkkyGeaiarLqeAlellkeaqklakkckskselledlkelke

LVTERLTKAETDNNTIFHETVPSDAALSEIVAADLFAFKPFEPD-----PSAVDILHRLMPLDVHLAISTFSEQKATLVRNV
 ..|.|..|| ||. | .| ||. . |..| .|.|    |..         . |....| |..|| | | .||.||.|||. 
rikekleeaekdNdfiyleevpdeveltsikkaklvkalpinellsltkekgedlfkklvPiavheaaslyseekaklvrde

0045098 (Phosphotyrosine protein) phosphatases II 864-1153 1.3e-65 216.9 In-house 25-274 (278) alignment
Range on Protein: 864-1153
Range on HMM: 25-274/278.0
TSCAAAERNVDRNRYRDILPYDRTRVHmqvlpgygstdDYINACHVRSLtsGcPDFVCAQGPKHSTSGDFWKMVVQQRSRVIVMVTNLEERGRPKCDRYW
 ..|  . |.|.|||.||||||..||.           ||||| ....   . . |...|||. ||  |||.|. .....||||.|.|.|.|| ||..||
itpalylgnldknRykdilpydhsrVk...........dYINAsyidgy..p.kkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrekcaqyw

PArcGETVSHPEtalglaLDVTLKEERETGPWIERDLIVETL-RPDHTKMVRHVKQFHYTSWPDHGVPASP--ETFLEFLLAVKQHHDAVQRQSQTAGE-
|   |... . .      . |||..| ... .. |.|.|. |   ... . |.|...||..||||||| .|    |||.|  ...........  .    
pe..ggsltygd......ftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslll

--PQSPLVVHCSAGVGRTGTFCCVYGVVAalpyvgnglpllaaresgaqrptrESqGGKLDIMNIVSRMREDRRF-MVQTVDQYKFCYLASLEAARR
  .. | .||||||||||||....| .                             .|..|. ..|. .|. |.. .||. .||.|.| . ||  .|
ldsggpvlVHCsaGvgRtGtlvaaylmle........................ll.eggvdlleavkelrsqRpglavqnleqyrflyefllelllr

subfamily_PTPN6_pd Subfamily PTPN6 828-1146 3.8e-65 214.9 In-house 9-292 (306) alignment
Range on Protein: 828-1146
Range on HMM: 9-292/306.0
LSETVAHLQQA-YPDGKSGFDKEFALLEMEDAAHNRDTSCAAAERNVDRNRYRDILPYDRTRVHMQvlPGYGSTDDYINACHVR-SLTSGCPDFVCAQGP
... | .|..     .|.|| .||  |. |.| .  . . .|  .|  .|||. |||.| ||| ..      . .|||||  .. .... .  .. .|| 
ieqrvselekeeeslekagfeeefeelqqeeakkllsrkegakpenkeknryknilPfDhtrvilk..epsvpgsdyinanyikkevkgsdksyiatqgc

KHSTSGDFWKMVVQQRSRVIVMVTNLEERGRPKCDRYWPARCGETVshpetaLGlALDVTLKEERETGPWIERDLIVETLrpDHTKMVRHVKQFHYTSWP
 ..|  |||.||.|. ||||||.|.  |||. || ||||.   ..        |  . ||  .|...  .| |.| |.    .. |  |.| |.|..|||
lettvsdFWrmvwqensrvivmttkevErgkekCarYWPdeeekee......yG.kisvtnvseksladYilRelsvskk..kkkkeerevfqyhfksWP

DHGVPASPETFLEFLLAVKQHHDAVQRQsqtagePQSPLVVHCSAGVGRTGTFCCVYGVVAALPYVGNglpllaaresgaQRptresqggKLDIMNIVSR
|||||..|...|.||  |..... ....       . |.|||||||.||||||  .  ..  . . |.            .         ..|| ..|  
dhgvpkdpgavLdfledvnrkqeeleea......eagpivvhCsaGiGRtGtfiviDillkliekkgl............da........didiqklvks

MREDRRFMVQTVDQYKFCYLA
.|| |  .||| .|||| | |
vreqrsglvqteqqykfvyka

subfamily_PTPN12_pd Subfamily PTPN12 841-1152 4.1e-65 214.5 In-house 5-278 (290) alignment
Range on Protein: 841-1152
Range on HMM: 5-278/290.0
DGKSGFDKEFALLEMEDAAHNRDT----SCAAAERNVDRNRYRDILPYDRTRVHMQVLPGYGsTDDYINACHVRSLTSGCpDFVCAQGPKHSTSGDFWKM
.|.  | |||  | .. ... ...    ... .|.|| .|||.|||||| .||...   .    .||||| ...  .. .  .. ||||   |  |||.|
egeeefakefqklkklsekykaekvysteagekeenvkknrykDilPydksrvelskieeee.gsdYinanfikgvegkl.eyiaaqgPLpktlddfWrm

VVQQRSRVIVMVTNLEERGRPKCDRYWPARCGETVSHPEtalglaLDVTLKEERetgpWIERDLIVETLRPDHTKMVRHVKQFHYTSWPDHGVPASPETF
. ... ...||. .. | |. ||.|||| . .|.. . |      . |||.||.    ... |... ||. .. |  |.|.|||||.|||||||.|... 
iweknveivvmaCrevelgkkkCerYWpeegeeelefge......fevtleeek....avdddflirtLkveaqkesrkvyqfhYtaWPDhgvPssaksl

LEFLLAVKQHHDavqrqsqtagEPQSPLVVHCSAGVGRTgtfccvyGVVAALPYVGNGLpllaaresgaqrpTRESQGGKLDIMNIVSRMREDRRFMVQT
||.. .|.....          . ..|||||||||||||       |.. |. || . |              .|    .||. ..| ..|..|  .|||
lelielvrelqe..........sedaPlvvhCsaGvGrt.......Gtiiaidyvrell.............kaekipeeldvfdlvlelrkqraalvqt

VDQYKFCYLASLEAAR
 .||.. | | .|  .
keqyelvykavaelvq

0042113 (Phosphotyrosine protein) phosphatases II 865-1148 5.6e-65 214.5 In-house 2-240 (245) alignment
Range on Protein: 865-1148
Range on HMM: 2-240/245.0
SCAAAERNVDRNRYRDILPYDRTRVHMQVLPGyGSTDDYINACHVrSLTSGCPDFVCAQGPKHSTSGDFWKMVVQQRSRVIVMVTNLEERGRPKCDRYWP
|.|. . |.|.|||.||||||.|||.... .|    .|||||..| ..   .| | ..||| ..| .|||.|. ......|||.|..||.||.||..|||
svallpenkdknrysdilpydhtrvklspdgg.dldsdyinasyv.dgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywp

ArcGETVSHPEtalglaLDVTLKEERETGPWIERDLIVETLrpdHTKMVRHVKQFHYTSWPDHGVPASPETFLEFLLAVKQHHDAvqrqsqtagEPQSPL
   ||.. . .      . |||..|   . .. | | |. |    .. .|.| ..||..||||||| ..|..|.|| .|...  .          .. |.
l..gesltygd......ftvtllseehlddytvrtlevtnl...gddesrevihyhylpwpdhgvpdllellldflefvrkalae.........dsngpv

VVHCSAGVGRTGTFCCVYGVVAALPYvgnglpllaaresgaqrptresqGGKLDIMNIVSRMREDRRFMVQTVDQYKFCYLASL
.|||||||||||||...| ..  | .                        ..... ..| ..|. |. .||| .||.|.| | |
lVHCsaGvgRtGtfiaaylmleqlek.......................elgvsleeavkelrsqRpgavqtpsqyrflyeall

Y_phosphatase Protein-tyrosine phosphatase 872-1148 6.8e-63 207.6 Pfam-A 1-234 (235) alignment
Range on Protein: 872-1148
Range on HMM: 1-234/235.0
NVDRNRYRDILPYDRTRVHMqvlPGYGSTDDYINACHVRSLTsGCPDFVCAQGPKHSTSGDFWKMVVQQRSRVIVMVTNLEERGRPKCDRYWPARCGETV
| ..|||.||||||.|||..    |.... ||||| .|.. .     |...|||  || .|||.||.|....||||.|.|||.|| ||..||| . .|..
nkkknRykdilpydktrvkl...kgsegpsdYInAnyvkgyk.ekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeesl

SHPETALGLAldvtLKEERETGPWIERDLIVETLRPDHtkMVRHVKQFHYTSWPDHGVPASPETFLEFLLAVKQHHdavqrqsqtaGEPQSPLVVHCSAG
.. .  . |      ||....  .. |.| ..    ..    |.|||.|||.|||||||.||. .|... .|....           . ..|.|||||||
tygdikvelk....ekekedekeytlrklelkkkkees..ekrevkqlhytnWpdhgvpespkslldlirkveksk..........eaksgpvvVhCsaG

VGRTGTFCCVYGVVAALPYvgnglpllaarE-SgaqrptresqggkLDIMNIVSRMREDRRFMVQTVDQYKFCYLASL
|||||||...  ..  |             | .             .|...||...|. |. |||...||.|.| | |
vgRtgtfvaldilleqlea...........eee.............vdvlqivkelRkqRpgmvqsleqYiflykail

Y_phosphatase Protein-tyrosine phosphatase 872-1148 6.8e-63 207.6 In-house 1-234 (235) alignment
Range on Protein: 872-1148
Range on HMM: 1-234/235.0
NVDRNRYRDILPYDRTRVHMqvlPGYGSTDDYINACHVRSLTsGCPDFVCAQGPKHSTSGDFWKMVVQQRSRVIVMVTNLEERGRPKCDRYWPARCGETV
| ..|||.||||||.|||..    |.... ||||| .|.. .     |...|||  || .|||.||.|....||||.|.|||.|| ||..||| . .|..
nkkknRykdilpydktrvkl...kgsegpsdYInAnyvkgyk.ekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeesl

SHPETALGLAldvtLKEERETGPWIERDLIVETLRPDHtkMVRHVKQFHYTSWPDHGVPASPETFLEFLLAVKQHHdavqrqsqtaGEPQSPLVVHCSAG
.. .  . |      ||....  .. |.| ..    ..    |.|||.|||.|||||||.||. .|... .|....           . ..|.|||||||
tygdikvelk....ekekedekeytlrklelkkkkees..ekrevkqlhytnWpdhgvpespkslldlirkveksk..........eaksgpvvVhCsaG

VGRTGTFCCVYGVVAALPYvgnglpllaarE-SgaqrptresqggkLDIMNIVSRMREDRRFMVQTVDQYKFCYLASL
|||||||...  ..  |             | .             .|...||...|. |. |||...||.|.| | |
vgRtgtfvaldilleqlea...........eee.............vdvlqivkelRkqRpgmvqsleqYiflykail

0037934 (Phosphotyrosine protein) phosphatases II 864-1147 3.4e-62 205.5 In-house 2-238 (243) alignment
Range on Protein: 864-1147
Range on HMM: 2-238/243.0
TSCAAAERNVDRNRYRDILPYDRTRVHMqvlpgyGStDDYINACHVRSLtsgcPDFVCAQGPKHSTSGD----FWKMVVQQRSRVIVMVTNLEERGRPKC
.|.|  . |...|||.||||||..||.       .. .||||| ... .    | . . |||  .|  |    ||.|. .....||||.|.|.|.|| ||
fsiallpenlsknrysdilpydhsrvkl......eg.sdyinanliyvt....prliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekc

DRYWParcGETVSHPetalglaLDVTLKEERETGPWIERDLIVETLRPDHTKmvRHVKQFHYTSWPDHGVPASPETFLEFLLAVKQHHDAVQrqSQTAGE
..|||   ||.. ..       . |||..|.... .. | | .| | .|. .  |.| ..||..||||||| ||| .|.|| .|... ...   | .|  
aqywp...gevtygd.......ftvtllseehlddytvrtlllenldlddlt..rlvihyhylpwpdhgvPdspedlldfldevrefieell..sllald

PQSPLVVHCSAGVGRTGTFCCVYGVVAALpyvgnglpllaaresgaqrptresqggKLDIMNIVSRMREDRRF-MVQTVDQYKFCYLAS
...|..||||||||||||... | .   |                           ..|. ..| ..|| | . .||| .||.|.| | 
sggpvlVHCsaGvgRtGtliaaylmllll...........................gvdleeavkllreqRpgkavqtpsqyrflyeal

subfamily_PTPRB_pd Subfamily PTPRB 831-1083 1.2e-61 203.3 In-house 12-240 (293) alignment
Range on Protein: 831-1083
Range on HMM: 12-240/293.0
TVAHLQQAYPDGKSGFDKEFAllEMEDAAHNRDTSCAAAERNVDRNRYRDILPYDRTRVHMQVLPGyGSTDDYINACHVRSLTSgCPDFVCAQGPKHSTS
  .|...   | . .| .|.   |...  ... ...| ...| ..|||..||||| .||... | .  |..||||| ... ..|   .|. .||| ..| 
feehvkkmkadsdlrfseeye..elkavgkdqavkaaelavnraknrytnilpydhsrvkLaalkd.esgsDYinanyipgyns.prefiatqGPlpetv

GDFWKMVVQQRSRVIVMVTNLEERGRPKCDRYWPARcgetvsHPETALGlALDVTLKEERETGPWIERDLIVETlrpdhTKMVRHVKQFHYTSWPDHGVP
 |||.|| ...|..|||.|.| |.|. ||..||||       . ... |  . |||..|.|.  |. |.| .|      .|. |.|.|.|.|||||||||
ddfWrmvwekkssiivmltqlvekgkvkCeeYWPad......eepvlyG.dikvtlvaeeeledwvirelkiek.....ekeerkvrqyhftsWpdhgvP

ASPETFLEFLLAVKQHHDavqRQSQtagepQSPLVVHCSAGVGRTGTFCCVYG
 ...|.|.|. .|.....   ....     ..|.|||||||||||||| ..  
ektktlldfvrtvreaie...ktas.....krPivvhCsaGvGRtGtfialdr

subfamily_PTPRG_pd Subfamily PTPRG 829-1081 2.8e-60 199.1 In-house 4-240 (563) alignment
Range on Protein: 829-1081
Range on HMM: 4-240/563.0
SETVAHLQQAYPDGKSGFDKEFALLEMEDAAHNRDTSCAAAERNVDRNRYRDILPYDRTRVHMQVLPGYGSTDDYINACHVRSLTSGcPDFVCAQGPKHS
.| . |. . . ||. ||..||  |..| .... |.. . .. |  .||| .|..|||.||... |||  .. ||||| ..     .  .|. .||| ..
kefakhvaslhadgdigfseefealqsetiskdldaehsqkpenkrKnRylnivaydrsRvklsplpgkkkklDYinAnyidGyqks.kafiatqgplkd

TSGDFWKMVVQQRSRVIVMVTNLEERGRPKCDRYWPArcgETVSHPEtalglALDVTLKEERETGPWIERDLIVETLRPDHTKM---VRHVKQFHYTSWP
|  |||.|. .|.. .|||.|||.|||| |||.|||.   ... . .     || |||.||  .    .| |... |. ...|    ...|.|.|||.||
tfddFWrmiWeqnvaiivmitnlvergrrkcdvYWPk...desetyg.....alqvtlieeevlalytvrtlviknlklkkkkqcdteklvrqyhytkWP

DHGVPASPETFLEFllaVKQHhdavqrqSQTAGEPQSPLVVHCSAGVGRTGTFCCV
||||| ..   | |   ||..       |..  .   |.|||||||||||||.. .
dhgvPehslpvLif...vkks.......saankaeaGPivvHcsaGvgrtGtyivl

subfamily_PTPN13_pd Subfamily PTPN13 860-1150 3.4e-60 198.6 In-house 25-268 (273) alignment
Range on Protein: 860-1150
Range on HMM: 25-268/273.0
HNRDTSCAAAERNVDRNRYRDILPYDRTRVHMQVLPGygstddYINACHVRSLT-SGCPDFVCAQGPKHSTSGDFWKMVVQQRSRVIVMVTNLEERGRPK
   ... .  ..| |.||||..||||.|||...   |      |||| ...        ... .|||   |  |||.|| .|...||.|||.  |.|. |
pldtcevgkkkenkdknryrnvlPydetrvklgdegg......yinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweqkaeviamvtlekekgkvk

CDRYWPARCGETVShpetaLGLALDVTLKEERETGPWIERDLIVETLrpdHTKMVRHVKQFHYTSWPDHGVPASPETFLEFLLAVKQHHDavQrqsqtag
|.|||| . ....      .   |.|.| .  .   .  |.| |. .   ... .|.| ......|||||||.|.. .|.|.  |.. ..  .       
chrywPesknkklk.....vsnrlevellkvqkldgfvvralavkds...esgesrevahlnfvkwPdhgvPssaaellqfvaevrrlqt..d.......

epQSPLVVHCSAGVGRTGTFCCVYGVvaalpyvgngLPLLAaRESgaqrptresqggKLDIMNIVSRMREDRRFMVQTVDQYKFCYLASLEA
  ..|.|||||||.||.||. ... |          | |.. |.             ..|. .|| ..|| |. .||| ||| |.| | ||.
..agPivvhcsaGiGrsGtlitidvv..........lglie.rdk............efdvkeivrklreqrqgvvqtkdqyifvykailev

subfamily_PTPN3_pd Subfamily PTPN3 861-1146 8.6e-59 193.7 In-house 30-270 (280) alignment
Range on Protein: 861-1146
Range on HMM: 30-270/280.0
NRDTSCAAAERNVDRNRYRDILPYDRTRVHMQvlpgyGSTDDYINACHVRSLTSG---CPDFVCAQGPKHSTSGDFWKMVVQQRSRVIVMVTNLEERGRP
....|.|   .|...|||||||||| |||...      |. ||||| .|     .      .. .||| ..|. |||.|| .|.|..|||.|.| |||| 
glaisaarkpenlsknryrdilpydatrvklk.....esetdyinanyvnmeipstglvnryiatqGPlaktatdfWqmvweqksslivmlttlverGrv

KCDRYWPArCGETVshpetALGlALDVTLKEERETGPWIERDLIVETlrpDHTKMVRHVKQFHYTSWPDHGVPASPETFLEFLLAVKQHHdavqrqsqta
|| .|||   ....      .|  ..|....|.||  .. |.|...     .||  |.. |. |..||||||| ... ||||.  |.. .          
kChqyWPe.tedel.....eyg.efsvkcekedetksyvlrelvlkd...ketkeerkilqlqylaWpdhgvPddsadflefvervrklr..........

GEPQSPLVVHCSAGVGRTGTFCCVYGVvaalpyvgngLPLLAAREsgaqrptresqggKLDIMNIVSRMREDRRFMVQTVDQYKFCYLA
   ..|.|||||||.|||| .  .             | |. |.|             .. ...||..||. |  .|||..||||   |
sgkeePvvvhCsaGigrtGvlilleta..........lalieaae.............pvypldivrtmrdqramlvqtasqykfvCea

subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 823-1082 1.1e-58 193.8 In-house 2-234 (318) alignment
Range on Protein: 823-1082
Range on HMM: 2-234/318.0
VAIRALSETVAHLQQaypDGKSGFDKEFALLEMEDAAHNRDTScaAAERNVDRNRYRDILPYDRTRVHMQVLPGYgSTDDYINACHVRSLTSGcPDFVCA
. ...| . |..|..   .|.  ...|.  |. ...   .  |    . |  .||| .||.||.|||..| | |   . ||||| ..   ..    .. |
isvedleshvrrlre...sGelllseeyerlsrseetvtslks..lepvnkaknryanilaydhtrvkLqmlege.egsDyinanyidGyrrk.kayiaa

QGPKHSTSGDFWKMVVQQRSRVIVMVTNLEERGRPKCDRYWPARCGETVShpetalglALDVTLKEERETGPWIERDLIVETlrpDHTKMVRHVKQFHYT
|.|   |  |||.|| .| |.||||.|..||||. |..|||| .  ..          .| |.|||| |.. .. | . |.    .... .|.|.|.|||
qaPlpetieDfWrmvWeqnsavivmltqeeergkakvhryWPskgsrsyg........klvvelkeevelsdyvlrefkvtr...teeeesrqvrqyhyt

SWPDHGVPASPETFLEFLLAVKQhhdaVQRQSQtagepQSPLVVHCSAGVGRTGTFCCVY
||||.|||.|. ..|...  |..    .|..|.     ..|.||||||||||||.|. | 
sWpdegvpesgaslldlvrqvsk....aqqksg.....agpivvhCsaGvGrtGvfiavd

subfamily_Ptp69D_pd Subfamily Ptp69D 838-1083 1.1e-56 187.2 In-house 16-241 (307) alignment
Range on Protein: 838-1083
Range on HMM: 16-241/307.0
AYPDGKSGFDKEFALLEMEdaAHNRDTSCAAAERNVDRNRYRDILPYDRTRVHMQVLPGYGSTdDYINACHVRSLTSgCPDFVCAQGPKHSTSGDFWKMV
   | . |. ||.  || .    ...|. .. . |  .||| || ..|.||| .....|  .. ||||| ....      .|..||.|  .| ||||.|.
rkrdtdfglakeyekLear..eidkstkvsekkenalknRyedikafDktRvkLkkingkeds.dYinasfikgyke.kkkfiaaqdPveatigDfWRmi

VQQRSRVIVMVTNLEERGRPKCDRYWPARcgetvshP----EtalglALDVTLKEERETGPWIERDLIVETLRPDH--TKMVRHVKQFHYTSWPDHGVPA
 .| . .|||..||.|  | ||..|||              .      . |.| .|.... .|.|.| | .   .    .  |.| |.|||.|.|  || 
aeqevtlivmlsnlteknrkkcakYWpie.......devqyg.....dilvklvseekhsdyiiReldvskkkeesgevedsrkvvqyhytgWkDskvPe

SPETFLEFLLAVKQHHDAVqrqsqtagepQSPLVVHCSAGVGRTGTFCCVYG
.... |...  |....             .||.||||||||||.|.| ..  
vargllklieqvrelykln..........rsPivvhCsaGvgrsgifvalds

subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 863-1148 8.2e-56 184.1 In-house 19-265 (274) alignment
Range on Protein: 863-1148
Range on HMM: 19-265/274.0
DTSCAAAERNVDRNRYRDILPYDRTRVHMQVLPGYGSTDDYINACHVRSLTSGCPDFVCAQGPKHSTSGDFWKMVVQQRSRVIVMVTNLEERGRPKCDRY
|.      ..  .|||..||| ...|| ..   .  .  .|||| ...        .| .|||  .|  |||.|. |....||||.|.|.|. . || .|
dqeeldvfgsqtknryktilPnensrvllesessededssyinanyikGydeeskayvatqGPlpntvadfWrmiyqeevqvivmltklkeaneqkCavy

WPARCGETVSHPETALGlaldVTLKEERETGPWIERDLIVEtlrpdHTKMVRHVKQFHYTSWPDHGVPASPETFLEFLLAVkqhhdavQRQSQTAGEPQS
.| . .  .|.  . .     .. ..  |.  .  | |...     ...  |.|| . ||.|||| .| ...|.|...| |       ... ... .. .
fPdaedyeiserygdve....ikvekiverndysvrklvlk.....ylerersvkhywytdWPdhksPddantlldlvlev.......eesreeenakla

PLVVHCSAGVGRTGTFCCVYGVVAALPYvgnglpllaaresgaqrptresqGGKLDIMNIVSRMREDRRFMVQTVDQYKFCYLASL
| |||||||.|||| |  .   |  |                          ...|...||. .| ||  |||| .||.. . |  
pvvvhCsaGiGrtGcfiaisiavrqlre.......................eivvdvlkivcnlrldrGGmvqtseqyelihralc

subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 823-1082 1e-54 180.8 In-house 5-237 (319) alignment
Range on Protein: 823-1082
Range on HMM: 5-237/319.0
VAIRALSETVAHLQQaypDGKSGFDKEFALLEMEDAAhnrDTSCAAAERNVDRNRYRDILPYDRTRVHMQVLPGYGSTdDYINACHVRSLTSGcPDFVCA
. .. | | . .|..    |. ...||| ||.. ..    ... |  |.| ..|||..||.|||||| .. |.|  .. ||||| .. .       |. .
ievqeLkerlkalas...tgetllekefkllkeavnd...tfdsaskeenkkknryqnilaydrtrvvlseldgvegs.dyinasfidgyqer.ekfiat

QGPKHSTSGDFWKMVVQQRSRVIVMVTNLEERGRPKCDRYWPARCGETVshpetalGlALDVTLKEERETGPWIERDLIVETLRPDHTKmvRHVKQFHYT
|.|.. |  |||.|| ...| ..||.|.| |... |. .|||  . |.        |  | |||.||.|.  .| |.| ....  .     |.||.|.||
qaPlentiedfWrmvWeeessivvmltklveklkvklkkywpeenfeey.......G.rlivtleeeeeledyiirklklnkkssevet..Revkhfqyt

SWPDHGVPASPETFLEFLLAVKQhhdAVQRQSqtagepQSPLVVHCSAGVGRTGTFCCVY
.||||.|| .  . |..|  ...   ......      . |.||||||||||||||. . 
eWpdhdvPekatslldllkrirk...srektq......sgPivvhCsaGvGRtGtfivld

subfamily_PTPRA_pd Subfamily PTPRA 841-1086 1.2e-54 180.4 In-house 29-253 (330) alignment
Range on Protein: 841-1086
Range on HMM: 29-253/330.0
DGKSGFDKEFALLEmedAAHNR-DTSCAAAERNVDRNRYRDILPYDRTRVHMQVLPGYGSTdDYINACHVRSLTSgCPDFVCAQGPKHSTSGDFWKMVVQ
|    | .||  |    |.. .     |. | | ..||. .||||| .||...|. |  .. ||||| ..         |. |||||. |  |||.|. .
ddnklfreefnalP...agpiqatlelaskeenkeknrvvnilPydfsrvilsvkeGvees.dyinasfidGyke.kdkfiaaqGPkeetvedfwrmiwe

QRSRVIVMVTNLEERGRPKCDRYWPARCgeTVSHPEtalglaLDVTLKEERETGPWIERDLIVEtLRPDHT--KMVRHVKQFHYTSWPDHGVPASPETFL
|.|  |||.|.|.|| . || .|||     .|.. .      . |....| ..  .  |...|.   ||.|  | .| |.|||.||||| |||. |   |
qksativmltelkerkeekcaqywPdeG..lvtyGn......irvevedetvlvdytvrkflvq.qlpdatrekksrlvrqfhftswPdvGvPfepiGml

EFLLAVKQhhdavqRQSQTAGepqsPLVVHCSAGVGRTGTFCCVYGVVA
..| .||.       . |.||    |.||||||||||||||. .  |..
kllkkvkk......lnqqsag....pivvhcsaGvGrtGtfivldavle

subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 833-1082 4.1e-54 178.6 In-house 4-229 (281) alignment
Range on Protein: 833-1082
Range on HMM: 4-229/281.0
AHLQQAYPDGKSGFDKEFALLEmeDAAHNRDTSCAAAERNVDRNRYRDILPYDRTRVHMQVLPGYGSTdDYINACHVRSLTsGCPDFVCAQGPKHSTSGD
.||.|   . ..|| .|.. |.  ..  .  .. . |. || .|||..|  || |||...      .| ||||| .| ... |  ... .|||  ..  .
khlkqlsqndnaGfieeyekla..aigvdntataskadenvlknrYsnivaYDatrvkvtpneenknt.DYinanfvpgyk.gekeyiatqgPvPaslva

FWKMVVQQRSRVIVMVTNLEERGRPKCDRYWPARCGetvshpETALGlALDVTLKEERETGPWIERDLIVETlrpdHTKMVRHVKQFHYTSWPDHGVPAS
||.||..|. ..|||||.  | |. || ||||          |. .|  . |. ..|.|.  .||| . .|.    ..   |.|.|..||.||||||||.
fWqmvweqkvsaivmvtreieagklkChrYWPddns......elkyg.dvtvkstaeeekatyierkfkler....esgetreveqlaytaWPdhGvPat

PETFLEFLLAVKQHHDAVQRqsqtagepqSPLVVHCSAGVGRTGTFCCVY
.. .|||  .|.. ..  .           |||.|||||||||||.  . 
tkellefrkevlkltekktk.........aplvihCsaGvGrtGtyialD

subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 833-1085 3.6e-53 175.8 In-house 15-247 (298) alignment
Range on Protein: 833-1085
Range on HMM: 15-247/298.0
AHLQQAYP-DGKSGFDKEFALLEMEDA-AHNRDTSCAAAERNVDRNRYRDILPYDRTRVHMQVLPGyGSTDDYINACHVRSLtSGCPDFVCAQGPKHSTS
 .|..  .  . .|...||  |.      ..  .. | ...| ..||| ||...| .|| ..   .     ||||| .. .  .| . |. .|.| ..| 
qklaavkkkkkltgyalefqrlnsvsseieeeekevarkpenkkkNRyadiialdssRvvLekeda.deesdYiNAsflhay.kgrnafiatqaPltetv

GDFWKMVVQQRSRVIVMVTNLEERGRPKCDRYWPARCGETVSHpetalglaLDVTLKEERETGPWIERDLIVETLRPDhtkMVRHVKQFHYTSWPDHGVP
 |||.||... . .|||.||||| .. |. .||| .  ||  .        ..|.|... | .  | | |.|.  . .     |.|.|.|.|||||.|||
edFWrmvteedigtiVmltnleeldktkyhkywPdegketyge........itvsllskeefadlivrklkvskkkee...kerevrqlhftsWpdkgvp

ASPETFLEFLlavkqhhDAVQRQSQTAGepQSPLVVHCSAGVGRTGTFCCVYGVV
.  .. |..|       . |... | ||  ..|..|.|||||||.|||. .. |.
enatsvldll.......rkvrasqqqag..nkpvivqCsaGvgRsGtfiaidsvl

subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 826-1081 1.2e-51 170.7 In-house 4-236 (305) alignment
Range on Protein: 826-1081
Range on HMM: 4-236/305.0
RALSETVAHLQQAYPDGKSGFDKEFALLEMEdaAHNRDTSCaaAERNVDRNRYRDILPYDRTRVHMQVLPGYGsTDDYINACHVRSLTSgCPDFVCAQGP
 ||... |....|  . ..|..... .| .|   .  |  .   | |. .||...| ..|  |....  .  .   |||||..| .  .    .. ||||
ialddlaayikearvysdkgleaqykslyee..eesidvgk..keankaknrlkeitlldddriiltekesld.dsdyinasyvdgykr.kkkyivaqgP

KHSTSGDFWKMVVQQRSRVIVMVTNLEERGRPKCDRYWPARCGETVSHPETalglalDVTLKEERETGPWIERDLIVETLRPdhTKMVRHVKQFHYTSWP
 ..|  |||...|. . ..|||.|.| | |. || .||| . .|.. . |.       |.||.|...  .|||.| . . .    |  | | |.. |.||
lkntvadfWrliveekvstivmltklveggkdkCrqYWpesktekkefgef......svelksektasdyieRklkisiede..dkesrtvlqyqltdWP

DHGVPASPETFLEFLLAVKQHHDAVQrqsqtagepQSPLVVHCSAGVGRTGTFCCV
||||| .. ..|...  |....   .         . ||.|||||||||||.|..|
dhGvpqfatsllslikrvqkdqkkdk.........gvpllVhCsagvgRtGvfiav

subfamily_PTPN9_pd Subfamily PTPN9 841-1088 8e-51 167.8 In-house 13-250 (297) alignment
Range on Protein: 841-1088
Range on HMM: 13-250/297.0
DGKSGFDKEFALLEMEDAAhnRDTSCAAAERNVDRNRYRDILPYDRTRVHMQVLPGYGSTdDYINACHVRSLTSGcPDFVCAQGPKHSTSGDFWKMVVQQ
 ||.|  ||.| .  | ..      ..    |. .||| |.| ||.|||... ...   . ||||| .|         |. .||| . |. |||.|| .|
kgkrGlskeyaeirnepve..Gtflasklranleknrytdvlcydetrvvlakvdedeas.dyinanfvdGykqk.kafiatqGplkktvsdfWrmvWeq

RSRVIVMVTNLEERGRPKCDRYWPARCGETVSHPEtalglaLDVTLKEERETGPWIERDLIVETLRpdhTKMVRHVKQFHYTSWPDHGVPASPETFLEFL
. .||||.| ..|||| || .|||   ... .. .      | |.  | .|.  . .| | ..  .   |.  |.|  | ..||||.||| | ...|..|
evlvivmttrvvergrlkcgqyWpleeessaefgd......lsvsnveveeeedykvrvleiknvk...teesrkvthfqflsWPdyGvPssaaslldvl

LAVKQHHDAVQR--QSQTAGEPQ-SPLVVHCSAGVGRTGTFCCVYGVVAAL
 .|...  .. .   ....|.|.  |.|||||||.||||||. .   .. |
ekvrekqalavkelgdewkghpsgPPivvhcsaGiGrtGtfitldiclsrl

subfamily_PTPN1_pd Subfamily PTPN1 853-1087 1.1e-49 163.7 In-house 13-227 (290) alignment
Range on Protein: 853-1087
Range on HMM: 13-227/290.0
LEMEDAAHNRDTSCAAAERNVDRNRYRDILPYDRTRVHMQVlpgygSTDDYINACHVRsLTSGCPDFVCAQGPKHSTSGDFWKMVVQQRSRVIVMVTNLE
|.... |.. .|. |  ..| ..|||||. ||| .|....      .  |||||  |  |      .. .|||  .| . ||.|| .|.|. .||. .. 
ldirkeasdfptreaklpenrnlnryrdvspydhsrikler.....adndyinaslve.leeakrsyiltqGPlpntvdhfWqmvWeqkskavvmlnkvv

ERGRPKCDRYWPARCGetvsHPETALG-LALDVTLKEERETGPWIERDLIVETLRpdhTKMVRHVKQFHYTSWPDHGVPASPETFLEFLLAVkqhhdavq
|... || .|||        . |  |    | |.| .| ..  .. | | .| |.   |.  |.. .||||.||| ||| || .||.||  |        
ekeqikcaqywPqgee....ekellledtklkvkliseerksyytvrllelenlk...tqetreilhfhyttwpdfgvpespaaflkflfkv........

RQSQTAGEPQSPLVVHCSAGVGRTGTFCCVYGVVAA
|.| .  . . | |.|||||.||.|||| |  ... 
resGslssdvGpavihcsaGiGrsGtfclvdtclvl

subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 863-1082 1.3e-48 160.3 In-house 11-218 (270) alignment
Range on Protein: 863-1082
Range on HMM: 11-218/270.0
DTSCAAAERNVDRNRYRDILPYDRTRVHMQVLPGyGSTDDYINACHVRSLTSGCPDFVCAQGPKHSTSGDFWKMVVQQRSRVIVMVTNLEERGRPKCDRY
...  .| |.   |||.||||  .||| .. |    |.  |||| .||  ..    ...|.||. .|  .||.|....... |||.|.|||.|| ||.||
esdlpeaargkklnRyadiLPsPatRvrleelee.dsataYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkgrkkCerY

WPARCGETVSHPETALGLaldVTLKEERETGpWIERDLIVEtlrpDHTKMVRHVkQFHYTSWPDHGVPASPETFLEFLLAVKQHHDaVQRQSQTAGEPQs
|||. .|.|.  .  .     ..|.||.|.| .| . | .|    .. .  | |  |.|..||||||| .... |.    .|  .. |.|...   . . 
Wpaepkekvkledgkikv...lalseekeeg.yiltrlrle....ekgeerrlv.HfwyntWpdhgvpreedsslstdqllkmlra.vrrsekeldkae.

PLVVHCSAGVGRTGTFCCVY
||.||||||||||||.  . 
PllvHcsaGvgRtGtlialD

subfamily_PTPN14_pd Subfamily PTPN14 858-1078 1.5e-47 157.0 In-house 35-246 (300) alignment
Range on Protein: 858-1078
Range on HMM: 35-246/300.0
AAHNRDTSCAAAERNVDRNRYRDILPYDRTRVHMQvlPGYGSTDDYINACHVRSLTS-GCPDFVCAQGPKHSTSGDFWKMVVQQRSRVIVMVTNLEERGR
  .. ..|.|. . |...||..|.|||. .||...  |   ....|||| ...   .    ... |||| . |  |||.|| .|  ..|||.|. || |.
kredallstaklpenaeknrfkdvlPyednrvels..ptkenstgyinassikvsvggkersyivaqgPleltvqdfWqmvWeqgvqlivmlteeeedgk

PKCDRYWPArCGEtvSHPETALGlALDVTLKEERETGPWIERDLIVETLRpdhTKMVRHVKQFHYTSWPDHGVPASPETFLEFLLAVKQHHDAVQRQSQT
 |. .|.|  ...  .. .   |    || |  ....  | . | .. |    .|  | |  . || |||||||  ...||..|  |.    ........
eksfkyfPk.les..kkktvefg.kfkvttkfsedsdsvittglklkhlp...skeertvwhlqytDWpdhgvPeDvkgflsyLeevqsvrrktnseves

aGEPQSPLVVHCSAGVGRTGTF
  | . |..|||||||||||  
.keskPPvlvhCsaGvGrtGvl

subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 828-1086 1.7e-46 153.9 In-house 7-246 (325) alignment
Range on Protein: 828-1086
Range on HMM: 7-246/325.0
LSETVAHLQQAYPDGKSGFDKEFALLEMEDAAHnrdTSCAAAERNVDRNRYRDILPYDRTRVHMQVLPGYGSTdDYINACHVRSLtSGCPDFVCAQGPKH
. . | |...   . . || .|| ||  .|.        |.   |...||.......|..|| .. .   .|. ||||| ..|.   .   |. || |. 
vvnlvehvekkkaqdqdgfahefgllpsddgia...kkvamkpenkaknrfknvvaldksrvvletkkddpss.dyinasylrdd.kkkdvflaaqaPlt

STSGDFWKMVVQQRSRVIVMVTNLEeRGRPKCDRYWPARCGETVSHpetalGlALDVTLKEERETGPWIERDLIVETLRPDHTkmvRHVKQFHYTSWPDH
.| .|.|..|.. |. |.|..  |.  |  .|  ||| . |...       | .|.| |.   |   .. | | |   .  .|   | ||||.. ||.| 
atindlWrlvldWrcsvvvvlneld.lgkdrcavywpkemgksktf.....G.glevklrtieeisdyvhrvldvkqvkkGet...rsvkqfqlqswddm

GVPASPETFLEFLLAVKQHHDAVQRQSQTAGepqsPLVVHCSAGVGRTGTFCCVYGVVA
||.  | |.. .|  ||. .. |. ......    |..|||||||||||.| ..| ..|
Gvqkrpatlisilqlvkavservtantkast....pilvhcsaGvGrtGvfislysala

subfamily_PTPRK_pd Subfamily PTPRK 845-1085 4.9e-46 152.0 In-house 23-234 (314) alignment
Range on Protein: 845-1085
Range on HMM: 23-234/314.0
GFDKEFALLEMEdaahnrdTSCAAAERNVDRNRYRDILPYDRTRVHMQVLPGYGStDDYINACHVRSLTSgCPDFVCAQGPKHSTSGDFWKMVVQQRSRV
|| .|.  |            .|  . | ..||. |||.|||.|| .... |  |  |||||  . | .     |. .|||...|  |||..| ....  
gfkeeyeslfeg.......wdaakkdenreknrsgdilaydrsrvflitidgdps.sdyinaalidsykr.paafivtqgPlqetvkdfWrlvydencas

IVMVTNLEERGRPKCDRYWPArcgETVSHPEtalglaLDVTLKEERETGPWIERDLIVET-LRPDHtkMVRHVKQFHYTSWPDHGVPASPETFLEFLLAV
|||.|.| | || || .|||    .|  . .      ..|.| |       . | . ||   |. .   .| |.||....||||.|| | ...|...  |
ivmltelvevgrvkClkyWPe...dtevygd......ikvelvetellaelvvrifrveklargqe..eirevrqfqflgWpdhdvPvsatgllklvrrv

KQHHDAvqrqsqtagePQSPLVVHCSAGVGRTGTFCCVYGVV
|....            . ..||||||| ||||||. .  |.
kksqee..........eaGrivvhCsaGaGrtGtfiaidivl

subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 866-1087 1.5e-45 150.2 In-house 37-235 (515) alignment
Range on Protein: 866-1087
Range on HMM: 37-235/515.0
CAAAERNVDRNRYRDILPYDRTRVHMQVLPGyGSTDDYINACHVRSLTSGcPDFVCAQGPKHSTSGDFWKMVVQQRSRVIVMVTNLEERGRPKCDRYWPA
 |  | |  .|||..|||||..|| ..|.       ||.|| ...|. .    ....|||....  |||..|.|..   |.|||.|.|  . || .||| 
vaqeeinfkknryknilPydsvrvklevind.nPhsdyfnasyipsfdnd.kayiasqgPnkasvddfWrlvlqenvttiamvtklkegdkikcgkyWPd

RCGETVSHPETALGLaldvtLKEERETGpWIERDLIVetLRPDHtkmVRHVKQFHYTSWPDHGVPASPETFLEFLLAVKQHHDAVqrqsqtagepQSPLV
. |..|   .  . |     .  |  ||  | | | |  |. |.   .| | |||.| |||.|||    ..| .. .||  |. .          . ||.
kpgdsvkfGsikvel.....vsleactg.gikrkltv..lkgdd...srtvtqfhfteWPdkGvpkhtssllklikevkadhgqy..........thpli

VHCSAGVGRTGTFCCVYGVVAA
.|||||||||| .. .  ||| 
ihcsaGvGrtGvvisidsvvah

subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 866-1086 3.9e-45 149.0 In-house 3-200 (250) alignment
Range on Protein: 866-1086
Range on HMM: 3-200/250.0
CAAAERNVDRNRYRDILPYDRTRVHMQVLPGyGSTDDYINACHVRSLTSGcPDFVCAQGPKHSTSGDFWKMVVQQRSRVIVMVTNLEERGRPkCDRYWPA
 |   .| ..||| ||...| .|| ..   |     ||||| .. . .     |. .||| ..|  |||.||... | .|||.|||.| ..  . .|||.
vakkpqnkeknryadiialdssrvvLekekg.dkesdyinasflhgyder.kafiatqgPlqatiedfWrmvleeksgtivmLtnLkesekt.yhqywPv

RCGETVSHpetalglaLDVTLKEERETGPWIERDLIVETLRPDHTkmvRHVKQFHYTSWPDHGVPASPETFLEFLlavkqhhDAVQRQSQTAGepQSPLV
   |.  .        . |.|... | . .. | |..   .  .    |.|.|.|...||| |||.  .. ||.|       . ||.. | ||  ..|..
ekaekyGd........vtvsllskeefadytkrklklskakkade...rivrqlhfvvWPdkgvPevatavLell.......kkvqasqqqag..naPvi

VHCSAGVGRTGTFCCVYGVVA
|.|||||||.|.|. .. |. 
vqCsaGvgrsGafiaidavle

subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 846-1093 5.5e-45 148.3 In-house 12-242 (287) alignment
Range on Protein: 846-1093
Range on HMM: 12-242/287.0
FDKEFALLEMEDAAHNRDTSCAAAERNVDRNRYRDILPYDRTRVHMQVLPGYGStdDYINACHVRSLTSGcPDFVCAQGPKHSTSGDFWKMVVQQRSRVI
 |||.  |  .  .       |    .| .||| |.||.| ||| .   . .||  ||||| .| | |     |..||||  .| .|||..|...|| ..
vdkevdalkedsesstatfkaaeelaavkknryadvlPiddtrvllsaegelGs..dyinanyvasytdd.eafiaaqgPiaatvrdfwravletrsasv

VMVTNLEERGRPKCDRYWPARcgetvSHPETaLGlALDVT-LKEERETGPWIERDLIVETLrpdHTKMVRHVKQFHYTSWPDHGVPASPETFLEFLLAVK
...|   | .| || .||| |       |   .|    |. |. .     .  | | .  |   .|.  | |||... ||||.... .   .. | | ||
itmtreveearlkcykywPer.....evPmr.vG.GysvvlldydikePeygvralrlidl...etrearvvkqldllswPdkvlaPtavglirfvldvk

QHHDAvQRQSQTAGepqsPLVVHCSAGVGRTGTFCCVYGVVAALPYVGN
|| .. .|... .|    |||||...|.||.|..  .. .|  |  .|.
qhiel.ardasevG....PlvvhddvGiGrsGillatlvlvsrledlGr

subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 838-1081 1.6e-44 147.0 In-house 14-231 (287) alignment
Range on Protein: 838-1081
Range on HMM: 14-231/287.0
AYPDGKSGFDKEFALLEMEDAAHNRdTSCAAAERNVDRNRYRDILPYDRTRVHMQvlpgyGSTDDYINACHVRSLTSGcPDFVCAQGPKHSTSGDFWKMV
    |. || . |..||  .  ..     . |..| |.||...||..|  || ..     |  .|||||... .  .    |. |..|  .|  .|||..
ghakgnegfknqftvleqvtqrede.vthniasqnkdknRltqilvpdnyrvllk.....gehpdyinavfidgykek.kafiiaesPmfntarnfWkli

VQQRSRVIVMVTNLEERGRPKCDRYWPARCGetvshpeTALGlALDVTLKEERETGPWIERDLIVETLRpdHTKMVRHVKQFHYTSWPDHGVPASPETFL
 ...  .|||.....|  . .| .|||           . ||    ..| .|  .  .|||.| |.     ...  ..|||...|.|...|  ..|.| |
ddrnvtaivmlcqekendeevcyqyWpeeks.......vvlG.eyniellneevnagyierklevknkn..kagdkqqvkqyqitnWdstgkvtepqtil

eflLAVKQHHdavQRQSQTAgepQSPLVVHCSAGVGRTGTFCCV
   | ...     . | . .   ....|||||..|||...|| .
...lvieemy...ktqrkrg...ntsivvhCsdtvGrsamfcaa

subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 863-1087 4.5e-44 145.7 In-house 41-243 (297) alignment
Range on Protein: 863-1087
Range on HMM: 41-243/297.0
DTSCAAAER-NVDRNRYRDILPYDRTRVHMQVLPGyGSTDDYINACHVRSLTSgcpDFVCAQGPKHSTSGDFWKMVVQQRSRVIVMVTNLEERGRpKCDR
 ..  | .. | ...||..|||||. ||.....       ||.|| .|..       ... | |...|  |||.||....  .|||.....|| . || |
qpqtvaekkvnfeksRYkniLPydssRvkLaivnd.dpdsDyvnasfvkgnkh...rlittqmPmkatvadfWamvldeqvstivmlnddnerdk.kcar

YWPARCGETvshpetaLGlALDVTLKEERETGPWIERDLIVETlrpDHTKMVRHVKQFHYTSWPDHGVPA--SPETFLEFLLAVKQHHDAVQrqsqtage
||. .   |       .|  . |.|.   |    |.|.| |.    ...|. | |||.....|||. |.   | ...|...  |..... ..        
yWsdkgvtt.......fG.dvsvvllsvsereGfikrelevtk...gkakarrvvkqyqfveWPdkaverkdsassllklisevrkdfsqna........

pQSPLVVHCSAGVGRTGTFCCVYGVVAA
 ..||.|||.||||||| .. .  ||| 
.egPllvhclaGvGrtgvlltidsvvae

subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 862-1087 5.3e-44 145.3 In-house 34-236 (315) alignment
Range on Protein: 862-1087
Range on HMM: 34-236/315.0
RDTSCAAAERNVDRNRYRDILPYDRTRVHMQVLPGYgSTDDYINACHVRSLTSGcPDFVCAQGPKHSTSGDFWKMVVQQRSRVIVMVTNLEERGRPKCDR
  .  |  . |  .|||..|||.|..|| ..|.      .||||| ...|. .    ....|||....  |||.||.|..   |||||...|  . || .
yrqrvaretinfkknryknilPldsarvklevidds.Pdsdyinasyiksvddd.kayiasqgPlkasvddfwrmvlqekvttivmvtkkqegdkikcrq

YWPARCGETVSHPEtalglaLDVTLKEERETGPWIERDLIVetlRpdHTKMVRHVKQFHYTSWPDHGVPASPETFLEFLLAVKQHHDAVqrqsqtagepQ
||| | ...|   .      . |.| .   ..  . | |..   |  ...  | | ||..| |||.||.    ..|... .||  ..            .
ywPdrkadsvefGs......ikvellsleadtdgvarklvt...r..kseesrtvtqfqftewPdkGvdkqtssllklikevkadngkk..........e

SPLVVHCSAGVGRTGTFCCVYGVVAA
 .|.||||||||||| .. .  ||| 
fsllvhcsaGvGrtGvvisidevvaq

subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 832-1084 2.3e-43 143.3 In-house 12-235 (315) alignment
Range on Protein: 832-1084
Range on HMM: 12-235/315.0
VAHLQQAYPDGKSGFDKEFALLEMEdAAHNRDTscAAAERNVDRNRYRDILPYDRTRVHMQVLPGyGSTDDYINACHVRSLTSGcPDFVCAQGPKHSTSG
.... |     | || ...  .      |  |.  |    |...||| .|..||..||.. .|    .  ||.||  .   .     ...||||. .. .
ityvaqkkastkngfkqdyesipgg.qlhpldv..akkienkqknryiniiaydksrvqlpllen.dphsdyvnanfidGynkk.rryiaaqgpnvasvk

DFWKMVVQQRSRVIVMVTNLEERGRPKCDRYWPARcgetvshpETALGlALDVTLKEEREtgpwiERDLIVETLRPDHTKMVRHVKQFHYTSWPDHGVPA
|||..| ..    |||.||| |. . |...||| .        .   |  . ||.|.|       . .. | ||     . .|.| |.||||||| |||.
dfwrlvfeedigkivmltnlvegekrkaekywpdk........kviyG.kitvtrkseev.....nteytvrtlsvvfgdnirevvqlhytswpdmgvpk

SPETFLEFLLAVKQHHDAVQrqsqtagepqSPLVVHCSAGVGRTGTFCCVYGV
.  .....   |||||..            ...||||||||||||||...  |
ytiplmnlirtvkqhhtnsv..........gaivvhcsaGvGrtGtfitldav

subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 829-1082 4.9e-43 142.1 In-house 8-237 (290) alignment
Range on Protein: 829-1082
Range on HMM: 8-237/290.0
SETVAhlqQAYPDGKSGFDKEFALLEMedAAHNRDTSCAAAERNVDRNRYRDILPYDRTRVHMQVLPGYGS-TDDYINACHVRSLTSgCPDFVCAQGPKH
.|.||   .    |..|| ..|  |.   ....  .  . .. |  .||...|..||  |. .. ..|    |..|||||..        ... .||| .
gefva...nghakgnegfrnqfkmlds..gesehtvtvgltssnkllnRfanivvyddnritLrpisghkDCtneyinAcyikgyke.kkqyiatqgpvs

STSGDFWKMVVQQRSRVIVMVTNLEERGRPKCDRYWPARCGETvshpetaLGlALDVTLKEERETGPWIERDLIVETLRPDhtKMVRHVKQFHYTSWPDH
.|  ||||...|... .|||.||  | |. ||  |||..  ..       .|    ..| .|...   ||| | |.  . .  .  ..|.|.. |.|...
ntlvdFWkliwqekvtiivmltniieegkvkCqqYWpdsdtka.......yg.efsikllneetlneyierklevknknsa..gakqsvtqyqitnwdst

GVPASPETFLEFLlavkQHHDAVQRQSQtagepQSPLVVHCSAGVGRTGTFCCVY
|  . |.| |  .    ..    ||..      . ..|||||..|||...|| ..
gkvtnpqtillvi....eemyktqrkrg.....ntsivvHCSdtvgrsavfcaaa

0041856 (Phosphotyrosine protein) phosphatases II 872-1152 7.3e-43 141.6 In-house 1-172 (182) alignment
Range on Protein: 872-1152
Range on HMM: 1-172/182.0
NVDRNRYRDILPYDRTRvhmqvlpgygsTDDYINACHVRSLTSGCPdFVCAQGPKHSTSGDFWKMVVQQRSRVIVMVTnleergrpkCDRYWParcgetv
|.|.|||.||||||..|             |||||  ...   ..  |...|||  ||  ||..|. ... ..||..|         ...|||       
nldknrysdilpydhsr...........dldyInanlylgslpatr.fiatqgpllstvadflrmlkelgittivnlt.........eelywp.......

shpetalglaldvtlkeeretgpwierdlivetlrpdhTKMVRHVKQFHYTSWPDHGVPAsPETFLEFLLAVKQhhdavqrqsqtagePQSPLVVHCSAG
                                      ..  |.. |..|..|||||||  ....|.|. .|..              .. | .||||||
......................................ellerlgiqylylpwpDhgvpd.ldelldfieevle..............eggpvlVHCsaG

VGRTGTFCCVYgvvaaL---PyvgnglpllaaresgaqrptresqggKLDIMNIVSRMREDRRFMVQTVDQYKFCYLASLEAAR
||||||... |     |                              .... ..|. .|. |  ||.| .|| |..|| ||  .
vgRtgtlvaay.....lmkkl..........................gvsleeavklvrsrRpgmvitpnqyfflqlallelll

subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 836-1082 2e-41 137.3 In-house 26-245 (319) alignment
Range on Protein: 836-1082
Range on HMM: 26-245/319.0
QQAYPDGKSGFDKEFALLEmEDAAHNRDTSCAAAERNVDRNRYRDILPYDRTRVHMQVLPGYGStDDYINACHVRSLTSGcPDFVCAQGPKHSTSGDFWK
.. . | .. .  ||  .  . ..   | . |  ..| |.||. .||..|...| .. | |     ||||| .|    .    .. ||||.  |  |||.
ksdfdddltklevefrrac.klgvnladqtfanldqnkdknriinilafdknvvklerliGeef.sdyinasfvtGyqrk.dkyiaaqGPldntladfWr

MVVQQRSRVIVMVTnleergRPKCDRYWPARCGETVSHPEtalglaLDVTLKEERETgpWIERDLIVEtlRPDHTKMVRHVKQFHYTSWPDHGVPASPET
|. ....  ||..|      . || .||| .  ..  . .      ..|.. || .   .. ||. .   .  . | .|...|||.  |||.||| .|  
miweyncstivllt......kdkcsqywplkivikeerfk......vkvdsveetae..yvvrdiels..edgkekdirkitqfhflGwpdvGvpdypsd

FLEFLLAVKQHHDAVQRqsqtagepQSPLVVHCSAGVGRTGTFCCVY
.. ..  |.  ..  .         . ..||||||||||||..  . 
lmrlvkkvrhltskenh........ranivvhcsaGvGrtGvyivld

subfamily_ptpA1_pd Subfamily ptpA1 848-1081 1.9e-40 133.9 In-house 25-249 (418) alignment
Range on Protein: 848-1081
Range on HMM: 25-249/418.0
KEFALLEmeDAAHNRDTSCAAAERNVDRNRYRDILPYDRTRVHMQVLPGYgSTDDYINACHVRSLTsgCPDFVCAQGPKHSTSGDFWKMVVQQRSRVIVM
.|| |||  ..    .||    ..|  .||| .||| ..|||... .       ||||| ..        .|.|.|||   |  |||.|| ..| |.|||
eefrlle..esvgpsetsegdkkhntsknrytnilpvnhtrvqlkkiqdk.egsdyinanyidgay..pkqfictqgplpntiadfwrmvwenrcriivm

VTNLEERGRPKCDRYWPARCG-ETVSHPETALgLALDVTLKEERETGPWIERDLIVETLRPDHTKMVRHVKQFHYTSWPDHGVPASPETFLEFLLAVKQH
..   |  | ||||||| . | | .|         .     |  |     ||..|   .|       | . |..|  |||| .|   . | ..| .. ..
lsresencrikcdrywpeqiggeqfsiygngn.evfgtysvelveviqdpereiitrnirltfegetrditqyqyegwpdhnipdhtqpfrqllhsitnr

hdavQRQSQTAGEPQSPLVVHCSAGVGRTGTFCCV
    | |   . . . |..||||||||||||||  
....qnqiipssdrnvpiivhcsagvgrtgtfcta

subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 863-1082 3e-40 133.5 In-house 16-209 (284) alignment
Range on Protein: 863-1082
Range on HMM: 16-209/284.0
DTSCAAAERNVDRNRYRDILPYDRTRVHMQVLPGYGStDDYINACHVRSLTSGcPDFVCAQGPKHSTSGDFWKMVVQQRSRVIVMVTnleergRPKCDRY
| . |  ..| |.||. .||..|...| .. | |     ||||| ..    .    .. .|||.  |  |||.|. ....  ||..|      . || .|
dqtfanldqnkdknrighilafdknvvklerliGeef.sdyinasfitGyqrk.dkyiatqGPldntladfWrmiweyncstivllt......kdkcsqy

WPARCGETVSHPEtalglaLDVTLKEERETgpWIERDLIVEtlRPDHTKMVRHVKQFHYTSWPDHGVPASPETFLEFLLAVKQHHDAVQRqsqtagepQS
|| .  ..  . .      ..|.. || |   .. ||. .   .  . | .|...|||.  |||.||| .|  .. ..  |.  ..  .         ..
wplkivikeerfk......vkvdsveesee..yvvrdiels..edgkekdirkirqfhflgwpdvgvpdypsdlmrlvkkvrhltskenh........ra

PLVVHCSAGVGRTGTFCCVY
..||||||||||||.. .. 
nivvhcsagvgrtgvyivld

subfamily_PTPRN_pd Subfamily PTPRN 814-1086 9.6e-40 131.1 In-house 2-249 (297) alignment
Range on Protein: 814-1086
Range on HMM: 2-249/297.0
EEAGESNLDVAIRALsetVAHLQQAYPDGKSGFDKEFALLEMEDaAHNRDTSCAAAERNVDRNRYRDILPYDRTRVHMQVLPGyGSTDDYINACHVRSLT
||.  ||||..   .   |    . .   |. ..||.  |   . |... .. | ||.||..||....|||| .||...      ...|||||  .    
eepvvsnldistGhv...vlsyledhlknkdrlekewealcaye.aepstkevakaeknvkknrskavlpydhsrvklkeeas.aeksdyinasaildhd

SGCPDFVCAQGPKHSTSGDFWKMVVQQRSRVIVMVTNLEERGRPKCDRYWPARCGEtVSHpetalglALDVTLKEE-RETGPWIERDLIVETLRpdhTKM
   | .. .|||  ||  |||.|| .| . |||..|.||| |  .|.||||    | | |       . .| |  |   .  .. | . .  |.   |. 
prapayiatqgplastvadfwqmvweqGvvvivnltrleeegvkqckrywpdeGse.vyh.......iyevhlvsehiwcddylvrsfylknlq...tse

VRHVKQFHYTSWPDHGVPASPETFLEFLLAVKQHHDAvqRqSqtagepqSPLVVHCSAGVGRTGTFCCVYGVVA
 | | |||. |||..|||||. ..|||   | . .    | |       .|.|||||.|.||||... .  |..
trtvtqfhflswpeegvPasaksllefrrkvnksyrG..r.s.......cpivvhcsdGaGrtGvyilidlvln

subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 872-1082 1.9e-39 130.3 In-house 3-193 (237) alignment
Range on Protein: 872-1082
Range on HMM: 3-193/237.0
NVDRNRYRDILPYDRTRVhmqVLPGYGSTDDYINACHVRSLTSGCPDFVCAQGPKHSTSGDFWKMVVQQRSRVIVMVTNLEERGRPKCDRYWPArcgetV
|  .||| .|  || .||   || | ||. |||||......      ...||||  |.  |||.|| |..  ||||.| | |. . || .|||       
nkiknrygnivaydhsrv...vlkgagsgsdyinatylkgfdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywps.....t

SHPEtALGlALDVTLKEERETGPWIERDLIVETLrpDHTKMVRHVKQFHYTSWPDHGVPASPETFLEFLLAVKQHHDAVqrqSQtagepQSPLVVHCSAG
  |. | |  | |.|| . |   .  | |.. .    . | || ..|...|||||.|||    ..| |   . ..   |   |.      .| ..|||||
dqpa.ayg.vltvslkkkeefsdytvrslllskr..ltlkevrlihqyqftswpdrgvpqqtaallrfrkniinrsphv...se.....sgpwiihcsag

VGRTGTFCCVY
||||| |  . 
vgrtgiflvid

0051429 (Phosphotyrosine protein) phosphatases II 900-1154 2.9e-39 130.7 In-house 3-228 (272) alignment
Range on Protein: 900-1154
Range on HMM: 3-228/272.0
TDDYINACHVRSLtsGC---PD-FVCAQGPKHSTSGDFWKMvVQQRSRVIVMVTNLEERGRPKCDRYWP----ARCGETVSHPETALGLALDVTLKEERE
...|||| .|  .  |    |. . ...|| . |  |||..  ... ..||.....||||| |||||||     ..    ....| | .|| ||| .|  
lsgyiNardvggy..grvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseel

TGPWIERDLIVETLRPDHTKmvRHVKQFHYTSWPDHGVPASPetFLEFLLAVKQhhdavqrqsqtagepQSPLVVHCSAGVGRTGTFCCVYGVVAAlpyv
.  .| | |... | . ..   |.| ..|||.||||||| ..  .||.| .. .               . |..||||||..||||..... ...     
lldyilrellltlllsagea..revmhlhytdwpdhgvpqea..llellellld...............ggpvlvHCsaGkdRTGtvvallllllg....

gnglpllaaresgaqrptresqggkLD--------------IMNIVSRMREDRRFMVQTVDQYKFCYLASLEAARRY
                         ..              . ..|...|. |. .||| .||.|.| | ||..|..
.........................vsletivddYlltnlyleeaveelraqrpgavqteeqylflyeallellrsl

subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 862-1079 6.3e-39 128.6 In-house 21-246 (297) alignment
Range on Protein: 862-1079
Range on HMM: 21-246/297.0
RDTSCAAAERNVD--RNRYRDILPYDRTRVHMQVLPgygSTDDYINACHVRSLTSGCP-DFVCAQGPKHSTSGDFWKMVVQQRSRVIVMVTNLEERGRPK
|  | ..| ||    .||||||| .| |||...  .   .  ||||| .|       .  ...|||| ..|  |||..|..|  ||||||..|.| || |
rgesfssakrnsslrknryrdilatddtrvkllrvi...terdyinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmvaklqedGrdk

CDRYWPARCGETVSHPETALGLAlDVTlKEERETGPWIERDLIVEtlrpdhtKMVRHVKQFHYTSWPDHGVPASPETFLEF-------------LLAVKQ
|  |||   .|    ..  .      |  .| ..    |  ||         .  |.|.   . ||||||||.  |    |             .||. .
capywpsvvqerlkagdvvvefl.sst.sdefdrviltelqliyr.......sesrvvrhvqflswpdhGvpsdledlvrfqaqvcscciavpmmlalve

HHD---AVQRQSQTAGEPQ-SPLVVHCSAGVGRTGTFC
       .| .|  |  |.  .|.|||||||||.|   
mftamvflqleslraemprnayllvhcsaGvGrsGvvv

0049772 (Phosphotyrosine protein) phosphatases II 869-1158 7.2e-38 126.4 In-house 43-287 (314) alignment
Range on Protein: 869-1158
Range on HMM: 43-287/314.0
AERNVDRNRYRDILPYDrTRVHMQVLPGYGstDDYINACHVRSLtsgcPDFVCAQGPKHSTSGDF----------WKMVV--QQRSRVIVM---------
 ..| |.||| ||||.| .||. . ||..|   ||||| .|..      .|...|||.  |  ||          |.||.  ....|.|||         
lflnrdknryldilpad.nrvilpglpvsg..sdyinasyvdgf....lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivmsrdevlade

------------VTNLEERGrpkcdRYWPARCGETVShpetalglaldvtlkeeretgpwierdliveTLRPDHTKMVRHVKQFHYTSWPDHGVPaSPET
             ..| ..|      ...|.  |.                                 .   |. .  |.. ..... .||...| ..| 
lsrLdaAlgKtpllildgng.....neptaadlellk...............................eelydpelferlgikylripvpDgsap.lled

FLEFLLAVKQHhDavqrqsqtagePQSPLVVHCSAGVGRTGTFCCVYGVVAALPyvgnglpllaaresgaqrptresqggkLDIMNIVSRMREDRR----
|.||| ..... |           ...|..|||.||.||||||.... .. .|                            ...  .....|. |     
fdeflefieea.d...........kggpvlvHCkaGkgRtgtfvvaaylmkllg...........................vsleealedvrlkRpinpn

-FMVQTVDQYKFCYLASLEAARRYNDKY
  .... .|| |.. |.||. ... ..|
pgfieqleqyefilealleylkflkkfy

subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 863-1081 1.5e-36 121.0 In-house 31-229 (307) alignment
Range on Protein: 863-1081
Range on HMM: 31-229/307.0
D-TSCAAAERNVDRNRYRDILPYDRTRVHMQVlpgYGSTDDYINACHVRSLTsGCPDFVCAQGPKHSTSGDFWKMVVQQRSRVIVMVTNLEERGRPKCDR
.  .  | . | |.|||.|.   |..|. ...    | . ||| | ..   .     |.|||||...|  .|| |..|..   ..|. .. | .. ||..
egvtveafsantdknryqdvkcqdkgrivvkf...dglasdyihanylgiai.kpkkficaqgplentqysfwamaiqekvesvimlckvielakikceq

YWPARCGETVSHPETALGLALDvtLKEERETGPwIERDLIVETLRPDHTKMVRHVKQFHYTSWPDHGVPASPETFLEFLLAVKQHhdavqrqsqtagepQ
|||.  |..  . |..  ....      ..  |  |  . | ||. | ..  | .... .. |||.|||    | ...| ||. .              .
ywpleegqklvfgeapntisva..nlgakklap.dedlinvttlkvdwaqksrtiqhlqwenwpdrgvpqinltainlleavryd..............t

SPLVVHCSAGVGRTGTFCCV
 |.||||||||||.||  ..
npvvvhcsaGvGrsGtivai

subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 845-1081 3.4e-36 119.5 In-house 16-246 (301) alignment
Range on Protein: 845-1081
Range on HMM: 16-246/301.0
GFDKEFALLEmedAAHNRDTSCAAAERNVDRNRYRDILPYDRTRVHMQVLPGYG-STDDYINACHVRSLTSgCPDFVCAQGPKHSTSGDFWKMVVQQRSR
.|....  |.    .... ..    |.|   ||...| .||  |. ..  | .  .. .|||| .. . ..    |. |||| ..|  |||....|..  
kfeeqykelk...egedksctvglseenkalnrfknitvyddnriilkpkpnldlcqreyinasyidgyse.kkkfiaaqgpmkktlvdfWrliwqekpv

VIVMVTNLEERGRPKCDRYWPARCGETVSHpetalgLALDVTLKEERETGPWIERDLIVE------------TLRPDHTKMVRHVKQFHYTSWPDHGVPA
 |||||||.|. . || .|||    |. .         . |||..|     .. |.| |             ... ...|  ..| |.. |.||..||  
sivmvtnlkegtkskceqywpnseaeseef......gpftvtlvneqvyPdfvirqlnvkiqdgsnngyierkfkvksdksswdvlqlqvtdWpqdGvvr

SPETFLEFLlavkqhHDAVQRQSQTAGepqSPLVVHCSAGVGRTGTFCCV
 | | |. .      .| ..|| .  |   .|.|||||..|.|.|..| |
eprtvLqvi......ddvihrqqkigg...gpvvVHCSdtVsrsGvYcsv

0046846 (Phosphotyrosine protein) phosphatases II 901-1148 9.7e-36 118.5 In-house 12-170 (176) alignment
Range on Protein: 901-1148
Range on HMM: 12-170/176.0
DDYINACHVRSltsgcPDFVCAQGPKHSTSGDFWKMVVQQRSRVIVMVTNLEERGRPKCDRYWPARCGETVshpetalglaldvtlkeeretgpwierdl
 |||||  . .     . ... ||| ..|  ||..|. ... ...|..|.. | || ||..|||   .. .                             
ldyinanlilg.....srpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgi.............................

ivetlrpdhtkmvrhvkQFHYTSWPDHGVPASpETFLEFLLAVKQHHDAvqrqsqtaGepqSPLVVHCSAGVGRTGTFCCVYGVvaalpyvgnglpllaa
                 |.... ||||||| . | .||.| ..... ..        |    | .||||||.|||||... | .                
.................qylhlpwpDhgvpdl.elllellefirealke........g...gpvlVHCsaGigRtgtlvaayll................

resgaqrptreSQGGKLDIMNIVSRMREDRR-FMVQTVDQYKFCYLASL
             .  |.. ......|| |. ..||| .||.|.| . |
...........elekglsveealalvreqRplgavqtpeQyrflyefel

0036282 (Phosphotyrosine protein) phosphatases II 901-1144 1e-35 118.3 In-house 2-163 (174) alignment
Range on Protein: 901-1144
Range on HMM: 2-163/174.0
DDYINACHVrSLTSGCPDFVCAQGPKHstsgdFWKMVVQQRSRVIVMVTNLEERGRPKCDRYWPArcgetvshpetalglaldvtlkeeretgpwierdl
.||||| .. .|.   | ... |||       ||.|. .......||.....|.|. || .|||                                    
sdyinaspl.dlsyitprliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe...................................

ivetlrpDHTKMVRHVKQFHYTSWPDHGVPASPEtFLEFLLAVKQHHdavqrqSQtagEPQSPLVVHCSAGVGRTGTFCCVY--------GVVAAlpyvg
       ... ..|.. |..|. ||||||| ... .|||. .|....      |.    |. |..||||||||||||... |        ..| |     
.......lredlerlgiqylylpwpDhgvpdlsi.llefvkfveeal......se...dpggpvlVHCsaGvgRtGtlvaaylmlrglleslvda.....

nglpllaaresgaqrptresqggkldiMNIVSRMREDRRFMVQTVDQYKFCY
                           ...| ..|  |  |||| .||.|.|
...........................ldlvrelRlqrpgmvqtpsQyrfly

0043147 (Phosphotyrosine protein) phosphatases II 900-1144 2.1e-35 117.3 In-house 4-154 (172) alignment
Range on Protein: 900-1144
Range on HMM: 4-154/172.0
TDDYINACHVrSLTSGCPDFVCAQGPKHSTSGDFWKMVVQQRSRVIVMVTNLeergrpkcdrywparcgetvshpetalglaldvtlkeeretgpwierd
 .||||| .. .|.   ..|.. |||  .|  |||.|. ..  ..||..|.|                                                
gsdyinasyl.dlyyipdrfiatqgplrntladfwrmlkelgithivnltel................................................

livetlRPDHTKMVRHVKQFHYTSWPDHGVPaSPETFLEFLLAVKQHHdavQ--RqsqtagepQSPLVVHCSAGVGRTGTFCCVYGVVaalpyvgNGLpl
        | .. .|.. |..|..||||||| ..| .||||  .....   .  .        . | .||||||||||||... | .         ||  
......lydpellerlgiqylylpwpDhgvp.llellleflefidell...alsp........ggpvlVHCsaGvgRtgtlvaaylml.......lgl..

laaresgaqrptresqggklDIMNIVSRMREDRRFMVQTVDQYKFCY
                    .. ..|. .|| |. .||. .||.|.|
....................sleeavalvrekRpgavqnpsqyrfly

subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 862-1086 5.1e-35 115.6 In-house 35-194 (392) alignment
Range on Protein: 862-1086
Range on HMM: 35-194/392.0
RDTSCAAAERNVDRNRYRDILPYDRTRVHMQVLPGYgSTDDYINACHVRSLTSGCpDFVCAQGPKHSTSGDFWKMVVQQRSRVIVMVTNLEERGrpkcdr
 ....|  | |. .|||..|||||..||...|.    . .||.|| ...|. .    ....|||. ..  |||.|| |..   |.|||.|.|        
ypqtvaqkeinlkknryknilpydsarvkleviddi.pdsdylnasyipsfdnek.ayiasqgpnaaslddfwrmvfqenvttiamvtklkegd......

ywparcgetvshpetalglaldvtlkeeretgpwierdlivetlrpdHTKMVRHVKQFHYTSWPDHGVPASPETFLEFLLAVKQHHdavqrqsqtaGEPQ
                                               . . .| | |||.| |||..||    ..|.|.  || ..          |.  
...............................................kgddartvaqfhftewPdkdvpkhtssllkfikevkadf..........Gqyt

SPLVVHCSAGVGRTGTFCCVYGVVA
 ||..||||||||||   ..  |||
hpliihcsagvgrtgvvisidsvva

subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 834-1080 1.1e-34 114.7 In-house 10-231 (439) alignment
Range on Protein: 834-1080
Range on HMM: 10-231/439.0
HLQQAYPDGKSGFDKEFALLEMEDAAHNRDTSCAAAERNVDRNRYRDILPYDRTRVHMQVLPGYGStDDYINACHVRSLTSGcPDFVCAQGPKHSTSGDF
|...   . .  |...|  ..  .  .. ..| || | .  .|||.|. ..| ||| .| .||      |||| ...        .. .||||. |. ||
hvekldknkqeifkeifekinstspdyaciaslaaqeydqtknrykdvgafdhtrvtlqeipgvph.shyinanyikGyydd.klyiatqgpkkettddf

WKMVVQQRSRVIVMVTNLEERGRpkcdrYWPARcgETVSHPETAlglaldVTLKEERETGPWIERDLIVETLRpDHTKMVRHVKQFHYTSWPDHGVPASP
|..|.....  |||.||| |  .     |||.   . | . . |      |    . |   .. | . |   | |.|.  | | ||||..|||. |||  
wrlviekktvtivmltnlvesyk.....ywpsd..aevcygdia......vrvdrnielpnyvirgfkvfner.dttekertvlqfhyiawpdknvpaqa

ETFLEFLLAVKQHHDAvqrqsqtagEPQSPLVVHCSAGVGRTGTFCC
   |.|| |..   |          |   |.|||||||||||||  .
shvldflrainsandk.........eeygpvvvhcsagvGrtGtiia

subfamily_CG7180_pd Subfamily CG7180 855-1081 2.3e-34 113.4 In-house 23-243 (296) alignment
Range on Protein: 855-1081
Range on HMM: 23-243/296.0
MEDAA--HNRDTSCAAAERNVDRNRYRDILPYDRTRVHMQVLPGYGSTDdYINACHVRSLTSGcPDFVCAQGPKHSTSGDFWKMVVQQRSRVIVMVTNLE
.. ..  .. |  ..  . | ..||. ...||| .|| .. | |  ..| |||| .| |..    ...  ..||..| ..||..| .. .  .|..|.  
lkltprleigdCagglrkenreknrdvkvvPyDynRvvLekldGeeksd.Yinavyvdsflkk.keyivteapkketvdefWrlvydeeisavvvLtktf

ERGRpKCDRYWPARCgeTVSHPETALGLALDVTLKEERETGPWIERDLIVETL-RPDHTKMVRHVKQFHYTSWPD-HGVPASPETFLEFLLAVKQHHDAV
.  . ..  ||| .      . |  . .    .. . .     . . ..  |  . . .  .| ||.|..| |.  . || | ....|..  |..  . |
dfak.mypsywpnks..keqygeifveiveekqyanlkirtfkltkkivalteqekqvkaetRivklfqlteWeledkvPlstnalielrrrvrlwrekv

qrqsqTAGEPQSPLVVHCSAGVGRTGTFCCV
        . ..|.||..| |..|.| .. .
.....dedpeegPvvvvssdGasRsGvylai

0049260 (Phosphotyrosine protein) phosphatases II 919-1144 4.5e-34 112.7 In-house 11-143 (152) alignment
Range on Protein: 919-1144
Range on HMM: 11-143/152.0
FVCAQGPKHSTSGDFWKMVVQQRSRVIVMVTNLEERGRPKCDRYWparcgetvshpetalglaldvtlkeeretgpwierdlivetlrpdhtkmvrhvkQ
|...|||   |  |||.|. ..  ..|||.|.|.|.|..||..|.                                                      |
fiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi......................................................q

FHYTSWPDHGVPASPETFLEFLLAVKQHhdavqrqsqtAGEPQSPLVVHCSAGVGRTGTFCCVYGVVaalpyVGnglpllaaresgaqrptresqggkLD
.... ||||||| ... .|..||.....          | ... | .||||||||||||... | .       |                        ..
ylhlpwpDhgvpdlsqlllflllfiekl..........aldkggpvlVHCsaGvgRtgtlvaaylml.....lg........................vs

IMNIVSRMREDRRFMVQTVDQYKFCY
. ..|...|| |  .|.. .|..|.|
leeavalvrekRpgavpnpgqlrfly

subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 859-1083 5.9e-34 112.2 In-house 20-221 (283) alignment
Range on Protein: 859-1083
Range on HMM: 20-221/283.0
AHNRDTSCAAAERNVDRNRYRDILPYDRTRVHMQVLPGygstdDYINACHVR--SLTSGCPDFVCAQGPKHSTSGDFWKMVVQQRSRVIVMVTNLEERGR
  ..|. .|.|..|   ||...|.|.|. ||... ..      |||||...          ... ||.| . |  |||||| ...   |||.|.| |  |
vpdldadiasadenkrknrnqeivpadqwrvelksesr.....dyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfdekitaivmltklqedlr

PKCDRYWPARCGETVShpEtalglaLDVTLKEERETGPWIERDLIVETLRPDHTKMVrhVKQFHYTSWPDHGVPASPETFLEFLLAVkqhhdAVQRQSqt
 || .||| |  |     |      . |||..|     .| . |.. .    .....  .  . .  | . |  |  .... | . .     . |..|  
ikCsqyWPkrGsedyG..e......ftvtlrkettsnsfiikelllrvnssakstll..lahyqvidWleygeqaiinslvkfnkvi.....slqtes..

agePQSPLVVHCSAGVGRTGTFCCVYG
   ...|.|||||.|.|||..|. .  
...kkgPivvhCstgiGrtavfiaasa

subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 871-1084 5.9e-33 108.7 In-house 55-239 (290) alignment
Range on Protein: 871-1084
Range on HMM: 55-239/290.0
RNVDRNRYRDILPYDRTRVHMQvlpgYGSTDDYINACHVRSLTsgcPDFVCAQGPKHSTSGDFWKMVVQQRSRVIVMVTNLEERGRPKCDRYWPARCGET
 .. .|||.|.   |.||| ..     |   ||. | .|. |    . |. .||. ..|  |.|.||.|..  .|||. .| | |..||..|.| . ||.
tefkknrykdvvcndktrvilk....dGydGdyvhanyvkGlk...amfiltqGalkdtvidiwrmvlqekvaaivmlceliedGkakceqyypekeGev

VSHPETALGlaldVTLKEERETgPWIERDLIVETLRPDHTKMVRHvkqFHYTSWPDHGVPASPETFLEFLLAVKQHhdavqrqsqtAGepqsPLVVHCSA
..  | ..      ........   | . | |      . ....|   ..  ||||. |. |  ..|  | ....           .|    |.||||||
ltfGeitvl....cseeddkda.niikktlsvrdkdsGkehklkh...lkikswpdksvalstlallrtlrilrka..........sG....pvvvhcsa

GVGRTGTFCCVYGV
|.||||||  .   
GiGrtGtfvaievg

ALIX_LYPXL_bnd ALIX V-shaped domain binding to HIV 480-727 5.4e-32 99.2 Pfam-A 28-293 (296) alignment
Range on Protein: 480-727
Range on HMM: 28-293/296.0
EA-----AQRLEQAQEHLAGFQERFEAAAAKFESARKMA------------SDRLRQEHDDMKSSLQQAQQAVRLARDKLEAIEPRLQLLASPHDDLRAA
|.     ... ..... |   .|.... . . |. |..             .. ||.|  .....|..|... . .| |||.||. |.||.|| ..|.|.
eeslddleelkqavesildeakeqLdeeesedeklrskygarwtrqpsseltaelreelrkyreaLeeAsesDsqlrskleeieedlalLsspeeeleas

MPKASLMDLDVGtldADKAKRIEELLGKVQIMRQLRQDKWDEFRREAeKIDIGHQILT-CP-----DQDALMREALQPLDELRDQLQSNFDSQRRLLPVL
.|. | .. |     ....||..||| |.. ... |.   .| .... . |.  .||. .      ....|..|.|.  |.|...|...   |..||  |
lpssspeesdev...seqikrlrelleklnllkaeRaklleeLkeki.hdddiskilielnkksssneeqlfeeeLekfdplqerleqsiskQssllkel

VEVYASQGKARKHIKEVqDQQRAFIEGLLGAFDAFRAVQDRVHKLTDFETAFESRLRAFEQQSQQLEQAQT
 |....  ...|. .|   ..  ... |  |.|... ... . . ..| . ....| ..... ... .|..
keaneeflqdkkskyek.kerekvlqklenaydkykelssnleeglkFYndLlkileslrknvkdfvnarr

subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 871-1081 8e-32 105.3 In-house 7-194 (239) alignment
Range on Protein: 871-1081
Range on HMM: 7-194/239.0
RNVDRNRYRDILPYDRTRVHMQVLPGyGSTDDYINACHVRSLTSGCPDFVCAQGPKHSTSGDFWKMVVQQRSRVIVMVTNLEERGRPKCDRYWPARcget
 |  .||| .|. ||..|| .. |       ||||| ..|        ....||    .|||||.|. |.|  ||||.| | |  . || .|||      
vnkaknryanivtydhsrvvleklsn.dphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpds....

vshpeTALGLALDVTLKEERETGPWIERDLIVETLRpdHTkMVRHVKQFHYTSWPDHGVPASPETFLEfllavkqHHDAVQRQSQTAgepQSPLVVHCSA
     |.    | |||..      .| | ...  .   .|   |.| |.|.| |||.|||    . |         .  . ..|        | |.||||
.....tskycnlrvtlrktevfadyiirtfvmsqvg..qt.eeryvyqyhftvwpdkgvpqyatavlg.......lrrkitkdslpg...arpwvihcsa

GVGRTGTFCCV
||||||.|  .
gvgrtgaflvi

subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 871-1081 8.8e-32 105.2 In-house 6-193 (239) alignment
Range on Protein: 871-1081
Range on HMM: 6-193/239.0
RNVDRNRYRDILPYDRTRVHMQVLPGyGSTDDYINACHVRSLTSGCPDFVCAQGPKHSTSGDFWKMVVQQRSRVIVMVTNLEERGRPKCDRYWPARcget
 |  .||| .|. ||..|| .. |       ||||| ..|        ....||    .|||||.|. |.|  ||||.| | |  . || .|||      
vnkaknryanivtydhsrvvleklsn.dphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpds....

vshpeTALGLALDVTLKEERETGPWIERDLIVETLRpdHTkMVRHVKQFHYTSWPDHGVPASPETFLEfllavkqHHDAVQRQSQTAgepQSPLVVHCSA
     |.    | |||..      .| | ...  .   .|   |.| |.|.| |||.|||    . |         .  . ..|        | |.||||
.....tskycnlrvtlrktevfadyiirtfvmsqvg..qt.eeryvyqyhftvwpdkgvpqyatavlg.......lrrkitkdslpg...arpwvihcsa

GVGRTGTFCCV
||||||.|  .
gvgrtgaflvi

PTPc_DSPc_SM00012 1016-1148 1.2e-30 101.2 In-house 2-104 (105) alignment
Range on Protein: 1016-1148
Range on HMM: 2-104/105.0
VKQFHYTSWPDHGVPASPETFLEFLLAVKQHHDAVQRqsqtagepQSPLVVHCSAGVGRTGTFCCVYGVVAALPYVGnglpllaaresgaqrptresqgG
||..|||.||||||| ... .||.| |||... . ..        ..|.||||||||||||||.... ..  | .                        .
vkhyhytgwpdhgvPeesdsilellravkknknkses........skpvvVhCsaGvgRtgtfvaldillqqleket......................k

KLDIMNIVSRMREDRRFMVQTVDQYKFCYLASL
..|| .||...|. |. |||| .|| |.| | |
evdifqivkelrkqRpgmvqteeqylflyrall

subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 855-1081 2.6e-30 100.1 In-house 41-241 (305) alignment
Range on Protein: 855-1081
Range on HMM: 41-241/305.0
MEDAAHNRDTScaaAERNVDRNRYRDILPYDRTRVHMQVLPgygsTDDYINACHVRSLTSGCPDFVCAQGPKHSTSGDFWKMVVQQRSRVIVMVTNLEER
| ..| | . |   |. .. .|||.|.   |.. |...  .      ||| | .|         |.|||||   |  .|| ||.|..   |||. .  | 
mtqvafnanqs...adiaitknryqdvpcqdqsavkldkps....psdyihanyvgcpmipekrficaqgpldqtidefwwmviqnkveqivmlcktvel

GRPKCDRYWPARCGETVSHPETALGLalDVTLKEERETGPWIERDLIVETLRPDHTKMVRHVkqfHYTSWPDHGVPASPETFLEFLLAVKqhhdavqrQS
|. || .||||  || ..     .    .|.     |  . |.  |.  |   |..  |||.   ..| ||| |||    | ||.| |..         |
gklkcaqywpaaqgeklelksgivve..nvsgskpmerdaeiqitllnltysgdqkmsvrhl...qwtewpdrgvppckltslellsair........gs

qtagepQSPLVVHCSAGVGRTGTFCCV
      . |.|||||||.|||||  ..
......kvpivvhcsagigrtgtivai

0044763 (Phosphotyrosine protein) phosphatases II 883-1145 6.9e-30 99.4 In-house 1-165 (178) alignment
Range on Protein: 883-1145
Range on HMM: 1-165/178.0
PYDRTRVHMQVLPGYGSTDdYINACHVRsltSGcpDFVCAQGPkhstsGDFWKMVVQQRSRVIVMVTNLEERGRPKCDRYWPARCGetvshpetalglal
|.|||||... |.|. ..| ||||...     |   ......|      |..... ..  ..||..|.  |.|..|||.||| . |              
pldrtrvllsnleglersd.yinaseil...pg..lylgslpp.....addlellkelgithivnlteelelgflkcdpywpeeag..............

dvtlkeeretgpwierdlivetlrpdhtkmvrhvKQFHYTSWPDHGVPASPETFLEFLLAVKQHHdavqrqsqtaGEPQSPLVVHCSAGVGRTGTFCCVY
                                   |.... .|||||| ..| ||||. ......           |...| .|||||||||.||... |
..................................iqylhipipDhgvpdllehflefvefieeal..........dekggpvlVHCsaGvgRsgtlvaay

GVVAAlpyvgnglpllaaresgaqrptresqggKLDIMNIVSRMREDRRfMVQTVDQYKFCYL
 .                               .|.. ......|| |. .|.. .|....|.
lmkkl............................glsleeaielvrerRp.ivpnpgqlrqLye

subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 834-1082 7.5e-30 98.7 In-house 12-240 (305) alignment
Range on Protein: 834-1082
Range on HMM: 12-240/305.0
HLQQAYPDGKSGFDKEFALLEMEDAAHNRDTSCAAaeRNVDRNRYRDILPYDRTRVHMQvlPGYgsTDDYINACHVRSlTSGCPDFVCAQGPKHSTSGDF
 ....   |  |. .||. ..  .  .   .   |  .. ..|||.|.   |. ||...  . .    .|| | .| .  .    |.|.| | . |  ||
fvkrtlekgpaglraefvamkrfndfekmkafkea..qeagknrykdvgcldnnrvkle..gpw..pheyihanyvst.ptnpkrfictqaplektcadf

WKMVVQQRSRVIVMVTNLEERGRPKCDRYWPARCGETVSHPETALGLAL----DVTLKEERETGPWIER-DLIVETlrpdHTKMVRHVKQFHYTSWPDHG
| | .|..   | |. || |.|  ||  |.... .....  |    ...     |||| ....   ...  |..|       . .|.|...|.  ||| |
wymclqdkveaifmlcnllekgakkcleyfaskdkdvlefeekgqkisvkfessvtlkfrkdakakvtetvlvieg....pgekarkvthyhwidwpdrg

VPASPETFLEFLLAVkqhhdavqRQSqtagepQSPLVVHCSAGVGRTGTFCCVY
|||.  . ||.|           | |      . |.|||||||.||||.   . 
vpaadlailelleka........rps......kgpivvhcsagigrtgsvvmle

0051082 (Phosphotyrosine protein) phosphatases II 901-1146 1.3e-28 94.9 In-house 3-148 (151) alignment
Range on Protein: 901-1146
Range on HMM: 3-148/151.0
DDYINACHVRSLtsgcpdFVCAQGPkhstSGDFWKMVVQQRSRVIVMVTNLEERGrpKCDRYWPARCgetvshpetalglaldvtlkeeretgpwierdl
.||||.  | .       . . .||    . ||.... ..  ..||.....||||  .| .|.|.                                   
sdyinfsyvtgg......lyrsggp....ladflellkelgiktivnlrseeerg..ycpeylpelg.................................

ivetlrpdhtkmvRHVKQFHYTSWPDHGVPASPETFLEFLLAVKQhhdavqrqsqtagEPQSPLVVHCSAGVGRTGTFCCVYGVVAAlpyvgnglpllaa
             ..|.......|||.|.| |....|||| .. .              .. |..||||||.|||||....| .                
.............ievlhipildwpdpglplsfdavleflellld.............kkngpvlvHCsaGkgRTGtlvalylmllg.............

resgaqrptresqggkLDIMNIVSRMREDRRFMVQTVDQYKFCYLA
                ...  ... .|. |  .||. .|. |...|
................vsleealeeyrlkrpgvvqpnqqflfqlfa

subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 871-1080 2e-28 94.2 In-house 42-223 (288) alignment
Range on Protein: 871-1080
Range on HMM: 42-223/288.0
RNVDRNRYRDILPYDRTRVHMQvlpgygSTDDYINACHVRSLTSGCPDFVCAQGPKHSTSGDFWKMVVQQRSRVIVMVTNLEERGRPKCDRYWPARCGET
 |  |.||...   | |||...         |.  |..| | .     ..||| | ..| . .|||....  . |||...| |.|..| . |.| . ||.
anptrdryenlprcditrvkls......ddpdfyiaanvvssakykrrlicaqaPlngtieelWkmllesdveyivmlcellekGkeksaeyfPsklGek

VSHPETalglaldVTL-KEERetgPWIERDLIVETLRPDHTKMVRH-VKQFHYTSWPDHGVPASPETFLEFLLAVkqhhdavqrQSQtagepQSPLVVHC
.             |  |..|     |.. . | .||  ..   .  ||. |.  |.|.||| .  ..| .|  .         .|      | |.|||.
arigrl.......ctvvkkkr...adidklvkvsllriskegeekvivkilhlleWdddgvPenylsplrllevl.........ksl.....qkPivvhs

SAGVGRTGTFCC
|||||||||.  
saGvGrtgtlil

subfamily_CG42327_pd Subfamily CG42327 873-1046 2.2e-27 90.6 In-house 29-193 (319) alignment
Range on Protein: 873-1046
Range on HMM: 29-193/319.0
VDRNRYRDILPYDRTRVHMQVLPGYgSTDDYINACHVRSLTSGCPDFVCAQGPKHSTSGDFWKMVVQQRSRVIVMVTNLEERGRPKCDRYWPARCGetvs
 |..|. ...|   ||| .|  .     | |..| .||   .    ...|| .  ..| |||..| .|.||||| .|.| | |  .| .|.|.. .    
kdksrvinvvPlPetrvvlqrigdd.dkdeyldasyvrGyddapnsyiaaqvsledsssdfwrtvweqqsrvivqltdlselGikvcaeylPtket....

HPETALGLALDVTLKEERETGPWIERDLIVETLrpdHTKMVRHVKQFHYtSWPDHGVPASPETFLEFLLAVKQH
 ..| |   . ||||.      ..   |..  .   . .. |..  . |  |.. .|||......  || |.. 
ldntslyGdilvtlkgrevkdryaistlllkrv...dkeesrelthywy.kwleaevPaeeaaliamllevrss

subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 866-1081 3.8e-24 79.8 In-house 29-220 (281) alignment
Range on Protein: 866-1081
Range on HMM: 29-220/281.0
CAAA--ERNVDRNRYRDILPYDRTRVHMQV-LPGYGSTdDYINACHVRSLTSGcPDFVCAQGPKHSTSGDFWKMVVQQRSRVIVMVTNLEERGRPKCDRY
|..     |  .||| .|   | .||...| .|   || ||| | ..||       .. .||||. |  |||.|. |. .  |||. .. |  | ||  |
ctvfnqpvnnkknrylnipcldisrvqlkvkmpnknst.dyihanyirspflk.rgyiltqgpkketradfwrmiwqenttaivmlcqfletnrekcaey

WPARCGETVSHPEtalglaldVTLKEERETgpwIERDLIVETLRPDHTKMVRHVKQFHYTSWPDHGVPASPETFLEFLLAVKQhhdavqRqSqtagepqS
.|  .   .   .        .... |  |   ... |.   |   .    | . .. .  |||  || | | .|. |  ..       | |       .
fprnahcclqfdk........lsvsyedst...vnkslvttrlnlsyegetrlithwlwkewpdwqvpessevmlkilrkira......r.s.......t

PLVVHCSAGVGRTGTFCCV
| |.||||||||.||. .|
ppvihcsagvgrsgtlmav

0048076 (Phosphotyrosine protein) phosphatases II 1004-1146 8.5e-24 79.3 In-house 35-138 (145) alignment
Range on Protein: 1004-1146
Range on HMM: 35-138/145.0
TLRPDHTKMVRHVKQFHYTSWPDHGVPASPETFLEFLLAVKQHHDAvqrqsqtagepQSPLVVHCSAGVGRTGTFCCVYGVVAalpyvgnglpllaares
.| .. .  .|.. |..|..||||||| ..|..|||| ........             | .||||||||||||... | .                   
nltselellerlgiqylylpwpDhgvpdllellleflefieealke...........ggpvlVHCsaGvgRtgtlvaaylmll.................

gaqrptresqgGKLDIMNIVSRMREDRRFMVQTVDQYKFCYLA
            .... ... ..|. |...|....|..|.|..
...........lgvsleealelvrsqrpgavpnpgqlrflyef

subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 857-1081 2.2e-23 77.3 In-house 37-243 (310) alignment
Range on Protein: 857-1081
Range on HMM: 37-243/310.0
DAAHNRDTSCAAAERNVDRNRYRDILPYDRTRVHMQVlpGYGSTDDYINACHVRSLTSgCPDFVCAQGPKHSTSGDFWKMVVQQRSRVIVMVTNLEERGR
||  .   .  | .... .||| |..  | .||....       .||| | .|..       |.|.|||   |  |||.|. |.|.  |... .  | ||
dakqdssltyeaykkymhknrysdvvcldtsrvklki..dksryedyihanyvktnyl.rstficsqgplqhtiidfwrmifqeraesilllckvgeegr

PKCDRYWPARcGETVSHP---ETALGLALDVtlKEERE-TGPWIERDLIVEtLRPDHTKMVRhVKQFHYTSWPDHGVPAspetflEfllavkQHHDAVQR
|||  |||.  | | ..     | |. . .    |  . .  ..  .. |.  .|   | .| |.  ..  ||| |||       |      . |   ||
pkcvgywpsl.gvtetygcirvtnlsessee..feicnlavtfvpdnvpvd.eqpanlkelr.vslikwpnwpdrgvpd......e......kchtvpqr

QsqTAGEPQSPLVVHCSAGVGRTGTFCCV
    |   . | |||||||..|... . .
l..laqvrhgpcvvhcsagkdrlyvvval

subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 841-1085 4e-23 76.8 In-house 3-216 (267) alignment
Range on Protein: 841-1085
Range on HMM: 3-216/267.0
DGKSGFDKEFALLEMEDAaHNRDTSCAAAERNVDRNRYRDILPYDRTRVHMQvlpgyGSTDDYINACHVRSLTSGCpDFVCAQGPKHSTSGDFWKMVVQQ
| .  ..||| |..      .   |.  || | .|||. | |||| ||| ..      ....|||| .| .   .   |.  |.| . | .||.... .|
deeceiekefelikkisd.tsstisqsiaeknqernrlddnlpyddtrvilr.....tkeeeyinasyvegyktkn.afivtqdplkntitdfltvihdq

RSRVIVMVTNLeerGRPKCDRYWPARCGETVSHPEtalgLALDVTLKEEREtgpwiERDLIVETLRPdHTKMVRHVKQFHYTSWpdhGVPASPETFLEFL
.  |||..|.    .  .  ..|| . |..  . .    |... .|..| .     . ..|.  |.  . .  . |  ..|  |    . .  . .|. |
kvpvivlltkv...ftdnirlfwPPkmgqakkyqd....ltvehslekeen.....dyqiitlelkf.knesahnvtlyyykkw...nintnnkpylkpl

LAVKQHHdavqrQSQtAGepQSPLVVHCSAGVGRTGTFCCVYGVV
...  .      | .  |  . ||||.||.||||.|||  ..  .
fgilakn.....qle.ng..nrPlvvacsdGvGrsGtflvidsql

subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 863-1088 8.6e-23 75.5 In-house 34-236 (312) alignment
Range on Protein: 863-1088
Range on HMM: 34-236/312.0
DTSCAAAERNVDRNRYRDILPYDRTRVHMQvlpgyGSTDDYINACHVRSLTSgcPD-FVCAQGPKHSTSGDFWKMVVQQRSRVIVMVTNLEERGRPKCDR
|. |.|  .  | ||| .|  .|| |  .      |  . || |  |.  |   |. |||.||| ..|.  ||....   |  |.... . | |  || .
dsectaflkfkdlnrypniqcwdrgrftla.....gdenfyihanfvkictk..perfvctqgplentcthfwqlalslgstsiillcgfvedgsekcak

YWPARCGeTVSHPETALglalDVTLKEERETGPWIERDLIVETLR--PDHTKMVRHVKQFHYTSWPDHGVPASPETFLEFLLAVKQHhdavqrqsqtage
|     |  |   .  .          | | |      .    |.     |    ..... ..||||||.| | .| | .| |||.              
yisdivg.fvdledhrv....yteycteieiggkskdkithrvlkvvvkatgqesklnhyqwaswpdhgmpdscdtalrllsavkkd.............

pQSPLVVHCSAGVGRTGTFCCVYGVVAAL
 . |.. |||||||||||.. .  ..|||
.kkpviahcsagvgrtgtlaliesmiaal

subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 853-965 1.2e-22 75.1 In-house 28-152 (350) alignment
Range on Protein: 853-965
Range on HMM: 28-152/350.0
LEMEDAAHNRDTSCAAAERNVDRNRYRDILPYDRTRVHMQ-------VLPGYGSTDDYINACHVRSL---TSGCPDF--VCAQGPKHSTSGDFWKMVVQQ
|| .. .   |   .   .   .|||..||||...||...             ||.||||| ...      .  |||  . .|.|  ||  ||.|.... 
LesdsespsnDvilseGvelfaknrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykvilln

RSRVIVMVTNLEERGRPKCDRYWPA
  .||...|.. | .. ||.|||. 
kvkvilsltsdvelnlekcyrYWqe

0048179 (Phosphotyrosine protein) phosphatases II 1007-1145 3e-22 74.3 In-house 40-139 (144) alignment
Range on Protein: 1007-1145
Range on HMM: 40-139/144.0
PDHTKMVRHVKQFHYTSWPDHGVPASPETFLEFLLAVKQHHDavqrqsqtagePQSPLVVHCSAGVGRTGTFCCVYGVVaalpyvgnglpllaaresgaq
 ... . |.. |.....||||||| ..| .|||| .......           .  | .||||||||||||... | ..                     
yepefleregiqylhlpwpDhgvpdllellleflefieeale...........eggpvlVHCsaGvgRtgtlvaaylmk.....................

rptresQ-GgkLDIMNIVSRMREDRRFMVQTVDQYKFCYL
        |  |.. ... ..|. | ..|.. .|..|...
......klg..lsleealalvrsrrpgavpnpgqlrfLle

subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 866-1081 2.2e-21 71.1 In-house 29-223 (285) alignment
Range on Protein: 866-1081
Range on HMM: 29-223/285.0
CAAAERNVDRNRYRDILPYDRTRVHMQvlpgyGSTDDYINACHVRSLTSGCPDFVCAQGPKHSTSGDFWKMVVQQRSRVIVMVTNLEERGRPKCDRYWPA
 .| | | | ||| |.   . ||| ..         ||| |  .|        .. .|||   |  |||.|. |..   ..|.  | | |  ||  |.| 
ytayeanpdlnryadvrcieetrvvlk.....nhdrdyihaswmrmpgkdqstyittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekcalyype

RCGETVSHPETALGLAldvTLKEERETGPWIERDLIVETlrPDHTKMVRHVKQFHYTSWPDHGVPASPETFLEFLLAVKQhhdaVQRQsqtagepQSPLV
. || |   .  . |.     |||  .|  ..   ...|   | .    .... .   |||.  |     ..|.   ||.    |. .       . |..
klgevvkfgkyeitlt...eckeeaiagtilnaltvint..edasseplymnhvqvpwwpdqlapedarpmielykwvkk....vnpk.......ekpic

VHCSAGVGRTGTFCCV
|||||||||| ||  .
vhcsagvgrtatfvgi

subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 1016-1148 6.8e-19 62.8 In-house 217-341 (350) alignment
Range on Protein: 1016-1148
Range on HMM: 217-341/350.0
VKQFHYTSWPDHGVPASPETFLEFLLaVKQH-HDAVQRQSQTAGEPQSPLVVHCSAGVGRTGTFCCVYGVVAALPYvgngLPLLAARESGAQRPTResqg
| |...  |.| ..   || .|. |  ||..  |    .|    . .||..||||||||||||.. .  ..  .      |  |  .    .....    
vyqlqvknWkDlslllnPesilqale.vkndliddlfaeshldnarsspilvhCsaGvGrtGtlvtlDsllsdfei....lenltkesrkldvaak....

GKLDIMNIVSRMREDRRFMVQTVDQYKFCYLASL
 .  |  || ..|. |  |||..||. |.| | |
trDlisiivnelrkqrismvqnldqfifiYeall

subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 913-1080 2.1e-17 57.8 In-house 85-233 (301) alignment
Range on Protein: 913-1080
Range on HMM: 85-233/301.0
TSGCP-DFVCAQGPKHSTSGDFWKMVVQQRSRVIVMVTNLEERGRPKCDRYWPARCGETVSHPEtalgLALDVTLKEERETGPWIERDLIVETLRPDHtk
||| |  |...||| ..|| ||| |.||     |||...  |.   ||. | | . .|..          . .. ||       ..| | ||    .   
tsGhphrfiatqgPlkntsedfwamlvqydvekivmlgqkvekleekceeylpvkisekldigr....fkikiknkelilnkkiskrtlevedstgkf..

MVRHVKQFHYTSWPDHGVPASPETFLEFLLAVKQhhdavqrqSqtagepQSPLVVHCSAGVGRTGTFCC
  | |  . |..|.|.||| |     ...  ||.        |      . |.|||||||.||. .|  
atrtvthyqysewtdrgvPkshaelfdlmelvkk........s......ekPivvhcsaGiGrsvafig

subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 924-1083 4.2e-15 50.0 In-house 98-244 (302) alignment
Range on Protein: 924-1083
Range on HMM: 98-244/302.0
GPKHSTSGDFWKMVVQQRSRVIVMVTNLEERGRPKCDRYWPARCGETVSHPETALG-LALDVTLKEERETGPWIERDLIVETLRPDHtKMVRHVKQFHYT
 ||.||   .| .. | .  ..| .... | .  ||  |.  . |...   . ..  . ..  |.|  .        . ..  .  . |. . |. ....
vpkkstlekhwalieqynvaivvqlcsfvedeekkcaeyysdkvggelkfgrytvktvsvktdleeftdkksfklytveiknekkkk.kvkktvdilafs

SWPDHGVPASPETFLEFLLAVKQHHDAVqrqsqtagepqsplVVHCSAGVGRTGTFCCV-YG
.||||| |. ..| |. |   . .  .|              .||||||||||||.  . ||
awpdhGapkeaytaldilkfcesykknv..............lvhcsaGvGrtGtlvaikyG

subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 930-1150 4.9e-15 50.3 In-house 41-220 (255) alignment
Range on Protein: 930-1150
Range on HMM: 41-220/255.0
SGDFWKMVVQQRSRVIVMVTNLEERGRPKCDRYWPARCGETVSHPEtalglaLDVTLKEeRETGPWIERDLIVETLRPdhTKMVRHVKQFHYTSWPDHGV
   |....||... |.||.....| |. ||..|.|    |     .      ..||  .   . . .    |. ||     |  . || ..|. |...  
vdkfyqtivqtktevvvmlcdfaeegvekcssyfplekdeklklad......vnvtttk.ssadvvlrtleitstlge..kkkthtvkhysykGWiekna

PASPETFLEFLLAVkqhhdavqRQSQtagepqsPLVVHCSAGVGRTGTFCcvygvvaalpyvgnglpllaARESGAQ---RPTRESQGGKLDIMNIVSRM
|  ..  |. | .|        |.|.       ..|||||.|.||. .|                       |.  |   |  .... ..|| ....  .
Pelareilnilkvv........rdsk.......svvvhCstGiGrsaafv....................laelvyqkmirsldttetveldylslleel

REDRRFMVQTVDQYKFCYLASLEA
|. |.  ..|  |  |. |  |. 
rskrkraihtPlqlafsilmvldl

subfamily_egg_pd Subfamily egg 856-971 9.4e-15 49.1 In-house 24-135 (307) alignment
Range on Protein: 856-971
Range on HMM: 24-135/307.0
EDAAHNRDTSCAAAERNVDRNRYRDILPYDRTRVHMQVLPGYgSTDDYINACHVRSlTSGCPDFVCAQGPKHSTSGDFWKMVVQQRSRVIVMVTNLEERg
|.....     ||.. | .. | . .   | .||....  |   .||.| | .|.       .|..|| |   |  |||.|| |.. . |||.|   |  
eesvdeislttaasdnnlekarskrvhckdssrvklelrrGq.ylddfihanrvkG.kpllnefilaqaplkntvddfwrmvfqeevqyivmltsrkes.

rPKCDRYWPARCGETV
  .|. |||    ...
.erceyywpkaesdsl

subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 853-964 1.2e-12 41.9 In-house 29-154 (349) alignment
Range on Protein: 853-964
Range on HMM: 29-154/349.0
LEMEDAAHNRDTSCAAAERNVDRNRYRDILPYDRTRVHMQVLPG-------------YGSTDDYINACHVrSLTSGCPD--FVCAQGPKHSTSGDFWKMV
|| .| ..  |   .   .   .|||.|||||. .|| ..  .               |  |||||| .. .||   ..  ... | |  ||  ||.|..
lesdddseiddvilseGvelfaknrykdilPyehsrvklkkslksskvikastsesdsgklddyinanyl.kltrisvekkyiatqaPlPstvddfykvi

VQQRSRVIVMVTNLEERGRPKCDRYWP
. .. .... ... .| .  |||.|| 
llngvklvlsLnddkelslekcdiywq

subfamily_eak_pd Subfamily eak 855-1039 2.8e-12 40.7 In-house 35-203 (332) alignment
Range on Protein: 855-1039
Range on HMM: 35-203/332.0
MEDAAHNRDTSCAAAERNVDRNrYRDILPYDRTRVHMqvLPGYGSTDDYINACHVrSLTSGCPDFVCAQGPKHSTSGDFWKMVVQQRSRVIVMVTNLEER
..|  . .  | .|   .|.||   .|.||||  |..   .     . ||||  .  ..     .. .  ....    ||.||..|.|  ||.. .  | 
lddyqrllsisetarleavnrn.vvkivpydrylvrl..tssqlnrlGyinasla.efsevGrkyiltGiasedkvfafwqmvleqkspaivqlledvel

GRPKCDRYWPARCGETVSHpetalGlALDVTLKEERETGPWIERDLIVETlrPDHTKMVRHVKQFhytSWPDHGVPASpETFLEF
.  | |.|.| .  | ...     |  |||. ||  . .    | |...    . |. | | | |    | .  .|   | || .
kleksdkyfpdktreelkf.....G.ildverkefvkrniletrllelsk..Gnethrvlhykvf...Gwtettlpky.edflal

subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 1016-1148 4.8e-12 39.9 In-house 220-341 (349) alignment
Range on Protein: 1016-1148
Range on HMM: 220-341/349.0
VKQFHYTSWPDHGVPASPETFLEFLLaVKQH-HDAVQRQSQTAGEPQSPLVVHCSAGVGRTGTFCCVYGVVAalpyvgnglpLLAARESGAQRPTRESQG
. |. .  |.| ..   | ..|. |  ||..  |    .     .  |.|.|||||| ||||... .  ...          .|   .    . . ... 
llqlqvknwldlslllnPisilqale.vkndliddlfarlyldtdqlstllvhcsaGcGrtGvlvtldllls..........ileplqnesnkiklqall

gKLDIMNIVSRMREDRRFMVQTVDQYKFCYLASL
 |  |. ||  .|  |  ||| . |. ..| | |
.kDlisiivnelrkqrismvqnlaqfiaiyealL

subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 918-1081 5.2e-12 40.3 In-house 5-154 (198) alignment
Range on Protein: 918-1081
Range on HMM: 5-154/198.0
DFVCAQGPKHSTSGDFWKMVVQQRSRVIVMVTNLEERGRPKCDRYWPARCGETVSHPETALGlALDVTLKEERETGPWIerdLIVETLRPDHTkmvRHVK
 ....| | . |  |||.|| .  |  |||| . .         |||.    |  .   ..  .  .| | .      |   |  .|  |  |   | . 
ryiatqhplretladfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvt.tktittkpdytitali...ltnnttappst...reis

QFHYTSWPDHGVPASpETFLEFLLAVKQhhdAVQRQSQtagEPQSPLVVHCSAGVGRTGTFCCV
.. .||| ..  |     |. |..| ..     ..  |   | ..|..|||| | | || | ..
hyqftswkekttpnv.alfvgfvvasre...vskkyeq...ekdapvivhcsdgqgftgvfval

subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 918-1081 5.9e-12 40.2 In-house 6-155 (199) alignment
Range on Protein: 918-1081
Range on HMM: 6-155/199.0
DFVCAQGPKHSTSGDFWKMVVQQRSRVIVMVTNLEERGRPKCDRYWPARCGETVSHPETALGlALDVTLKEERETGPWIerdLIVETLRPDHTkmvRHVK
 ....| | . |  |||.|| .  |  |||| . .         |||.    |  .   ..  .  .| | .      |   |  .|  |  |   | . 
ryiatqhplretmadfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvt.tktittkpdytitali...ltnnttappst...reis

QFHYTSWPDHGVPASpETFLEFLLAVKQhhdAVQRQSQtagEPQSPLVVHCSAGVGRTGTFCCV
.. .||| ..  |     |. |..| ..     ..  |   | ..|..|||| | | || | ..
hyqftswkekttpnv.alfvgfvvasre...vskkyeq...ekdapvivhcsdgqgftgvfval

subfamily_hpo-7_pd Subfamily hpo-7 932-1148 9.4e-12 39.4 In-house 49-224 (263) alignment
Range on Protein: 932-1148
Range on HMM: 49-224/263.0
DFWKMVVQQRSRVIVMVTNLEERGRPKCDRYWPARCGETVSHPEtalglaLDVTLKEEREtGPWIERDLIVETLRPdhTKMVRHVKQFHYTSWPDHGVPA
 |....||... |.||... .| |. ||..|.|    |     .      ..|.  .  .  . .    ...||     | .. ||.. |. |...  | 
kfyqtivqtktevvvmLcDfneegvekcssyfPlekdekqklan......vnvcttkvqs.dvllktlellstlge..KkkthtvkhysykgWiekndpe

SPETFLEFLlavKqhhdaVQRQSQtagepqsPLVVHCSAGVGRTGTfccvygvvaalpyvgnglplLAARESGAQ---RPTRESQGGKLDIMNIVSRMRE
 ..  |. |   |     | |.|.       .||||||.|.||.                       .  |.  |   |  .... ..|| ....  .|.
lareilnil...k.....varnsk.......slvvhcstGiGrsaa....................fsvaElvyqkmirsldttstveldylsLleelrs

DRRFMVQTVDQYKFCYLASL
 |.  ..|  |  |  |  |
srkraihtPmqLafsilmvL

subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 1013-1150 9.8e-12 38.9 In-house 88-193 (440) alignment
Range on Protein: 1013-1150
Range on HMM: 88-193/440.0
VRHVKQFHYTSWPDHGVPASPETFLEFLlavkQhhDaVQRQSQTAGepQSPLVVHCSAGVGRTGTFCCVYGVVaalpyvgnglpllaaREsgAQRptreS
 | .||.|| .|||.|||      |...    |  | |.   . ||  ..||.||||||.||||   .|  ..               ||  |.|    |
srtlkqyhyqgwpdkgvpkfagpvlkmi....q..d.vnesqekag..ngpllvhcsagagrtgviiavdsil...............re..akr....s

qgGKLDIMNIVSRMREDRRFMVQTVDQYKFCYLASLEA
   ..||..... ||..|  |||| .|| | . | ||.
..dqidifsfinsmrnnrpqmvqtpeqyafvheavleg

subfamily_PTPRD_pd Subfamily PTPRD 1113-1168 7.2e-11 36.4 In-house 243-299 (564) alignment
Range on Protein: 1113-1168
Range on HMM: 243-299/564.0
QGGKLDIMNIVSRMREDRRFMVQTVDQYKFCYLASLEAARRYNDKYG-QQFRRRQRT
. ...||...|...|..| .|||| .|| |.. | |||   .|..   ...... . 
eektvDiyqyvkalrkqRnamVqteeQYiFiheailealacgntevesenlkqhlqk

subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 893-1079 1.1e-10 36.2 In-house 36-209 (290) alignment
Range on Protein: 893-1079
Range on HMM: 36-209/290.0
VLPGYGS--TDDYINACHVRsLTSGCpDFVCAQGPKH-------STSGDFWKMVVQQRSRVIVMVTNLEERGRP----KCDRYWPARCGETVSHPetalG
|| |||.  .|||| | .|    .|   ..  | |..       ||  .|| |. | ... .||. . ||. .      | .| | . || .       |
vLkgygkrfnddyiHAnrvt.cpngl.rliltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCakYvpesvgeelkfk....g

LALDVtlKEERETGPWIERDLIVETlRPDHTKMVRHvkqFHYTSWPDHGVPASPETFLEFLLAVKQHhdavqrqsqtagepQSPLVVHCSAGVGRTGTFC
| .    |.  .    ..| |.|.    ..   | |     . .| .  |. .. |.|. .  ||..              ..| .|||  |. |  .. 
ltvkC..kskekeddvetRelvvkf.ddeeeftvtH...sllkgWnklnvqedtktllsliqkvkas..............ktpvivHcvdGiSrsAala





0038934 (Phosphotyrosine protein) phosphatases II 999-1082 1.6e-10 36.5 In-house 62-136 (194) alignment
Range on Protein: 999-1082
Range on HMM: 62-136/194.0
DLIVETLRPDHTKMVRHVKQFHYTSWPDHGVPASPETFLEFLLAVKQHHDAvqrqsqtagEPQSPLVVHCSAGVGRTGTFCCVY
||  ..   |.... ..  ...   .||.|.. | |. |.|| .|......          |.   .||| ||.|||||... |
dltnteryYdpeefekagieylklpfpddgtvPsleillrfldlvdeflne.........dpggvvaVHCkaGlgRtGtlvaaY

subfamily_PTPN9_pd Subfamily PTPN9 1113-1153 5.9e-10 33.7 In-house 252-292 (297) alignment
Range on Protein: 1113-1153
Range on HMM: 252-292/297.0
QGGKLDIMNIVSRMREDRRFMVQTVDQYKFCYLASLEAARR
. |..|... |...|. | |..|| .||.||||| || | .
evgtvdvvetvkllrtqrafsiqtpeqyefcylavleyale

subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 871-965 9e-10 32.6 In-house 95-180 (244) alignment
Range on Protein: 871-965
Range on HMM: 95-180/244.0
RNVDRNRYRDILPYDRTRVHMQVlpgYGSTDDYINACHVRSLTSgCPDFVCAQGPKHSTSGDFWKMVVQQRSRVIVMVTNLEERgrpkcDRYWPA
 |  .||    ||.|  || .         . ||||  |  |     ... .| |   || |||||....   |.|..  .||      | ||| 
nnswknregaglpfdfnrvplsk...gsmgntyinasfvgclgr.taeyiltqhpladtsmdfwkmmlerhvnvlvvlgsveee.....deywpd

subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 1113-1175 1.6e-09 32.2 In-house 245-308 (319) alignment
Range on Protein: 1113-1175
Range on HMM: 245-308/319.0
QGGKLDIMNIVSRMREDRRFMVQTVDQYKFCYLASLEAARRYN-DKYGQQFRRRQRTLIPVIPE
. | ||. ..|||.|  | .|||. .||||.| | |||.  .. .   |..| | ..|   ...
eegvlDvfstvsrlRtqRnimvqrpeqYkfiyealleaveagdteievqdlrdrlkqlaekvad

subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 871-1080 2.4e-09 31.2 In-house 46-230 (303) alignment
Range on Protein: 871-1080
Range on HMM: 46-230/303.0
RNVDRNRYRDILPYDRTRVHMqvlpgygSTDDYINACHVRSLTSGcpDFVCAQGPKHSTSGDFWKMVVQQRSRVIVMVTNLEERGRPKCDRYWPaRCGET
.|.|.||. |..  | ..|..       |   || | ..   .|     . .| |   |. |||.|...|. ......    |  .   |  .| |  . 
knmdknrfvdvicldhskvkl.......sdssyihasyleldssk..kailtqlplshtaadfwqmiieqkvkcvlllltdseydklggdsvfp.rnqdf

VSHPETALGLAldvTLKEERETGPWIERdliVETLRPDHTKMVRHVkqFHYTSWPDHGVPASPETflEFLLAVKQHHDAVQRQSqtagePQSPLVVHCSA
.   | .. .     .|.   .  |  .   | ..   . |   ||   || .||   .|.      .|.  . |    ... |     . .| |    .
lkfeersirvg...efkrvelgdgwvlk...vlsvsngdyksflhv..hhykawphnsipsdgsp..kfvkqiwqlqsvlrkys.....dstptvymsls

GVGRTGTFCC
|.||.|||. 
gcgragtfal

subfamily_Sponge-PTP3_pd Subfamily Sponge-PTP3 834-912 6.5e-09 29.9 In-house 13-84 (95) alignment
Range on Protein: 834-912
Range on HMM: 13-84/95.0
HLQQAYPDGKSGFDKEFALLEMEDAAHNrdtSCAAAERNVDRNRYRDILPYDRTRVHMQVlpgyGSTDDYINACHVRSL
|. . . .    ||.||  . |   |     .. ..| |. .||. .|.||| ||| .          |||||| |   
hvlemhsnsdqefdnefksismtsgapy...tvgsseanipknrflnifpydatrvvltt....krdsdyinacfvdgy

subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 1113-1178 6.5e-09 30.3 In-house 242-308 (318) alignment
Range on Protein: 1113-1178
Range on HMM: 242-308/318.0
QGGKLDIMNIVSRMREDRRFMVQTVDQYKFCYLASLEAARRYNDK-YGQQFRRRQRTLIPVIPEEGT
. . .|....|...|| |  |||| |||.|.| . |||   .. .   ...|.| | |  . || ||
aealvDvfqtvkqlreqrnlmvqtedqyefiydvllealasgdtevdasdlrsrirelreqdpesgt

subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 859-1079 4.1e-08 27.0 In-house 39-236 (302) alignment
Range on Protein: 859-1079
Range on HMM: 39-236/302.0
AHNRDTsCAAAERNVDRNRYRDILPYDRTRVHMQvlpgyGSTDDYINACHVRSLTSGcPDFVCAQGPKHSTS---GDFWKMVVQQRSRVIVMVTNLEERG
  . .  | |  .|...|.  |.  .| ..| ..     .. |.|.|| .|     . .  . || || ...    .||.|| |..   .|..   ||  
kvdlek.Ckafkknlkknqsedvpildsnlvkle.....aepdsyvnaskvevPelt.rsiilaQlpkvdsedsveeFWrmvfqekivsvvilvgeeelk

RpKCDRYWPARCGETVSHPETALGLALdVTLKEERETgpwierDLIVETLRPDHTKMVrHVKQFHYTSWPDHGVPASPETFLEFLLAVkqhhdaVQRQSQ
.   . ..| . |. . . .  .     |  .|| .|       ...| |  . .  |  ..  . | |... || .  .  .    |       .....
k.tlselfpkksgdykeygkmfvNnrk.Vekaeeekt......ryviEvlPegcsnsv.lanvyvltnWkqkkvpvkyaeliktaakv......fakkik

TagepQSPLVVHCSAGVGRTGTFC
.    ....|.    |.|| |.| 
a....dentvivSknGaGRagafl

subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 867-947 7.1e-08 26.3 In-house 32-115 (347) alignment
Range on Protein: 867-947
Range on HMM: 32-115/347.0
AAAERNVDRNRYRDILPYDRTRVHMQVLP-GYGST---DDYINACHVRSLtSGCPDFVCAQGPKHSTSGDFWKMVVQQRSRVIVM
.  |.....|| .|    | ||| .       . .   . |||| |..       ... .| |  .|  ||||||   .   .| 
vewekslsknrskdvklidatrvvlspeksknsraddvetyinashikfd.naskeyiltqyplpdtvrdfwkmvsvtkvtqvvt

subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 1112-1152 7.6e-08 26.8 In-house 237-277 (281) alignment
Range on Protein: 1112-1152
Range on HMM: 237-277/281.0
SQGGKLDIMNIVSRMREDRRFMVQTVDQYKFCYLASLEAAR
..  .||. ..|  .|..| .||||| ||.| |.| |.|  
aeleeldvkavvaelrkernlmvqtvvqyefvykavldald

subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 1116-1156 8.1e-08 26.8 In-house 255-295 (298) alignment
Range on Protein: 1116-1156
Range on HMM: 255-295/298.0
KLDIMNIVSRMREDRRFMVQTVDQYKFCYLASLEAARRYND
..|....| ..|..|  .||| .||.|.| | |||   .||
vvDvfqvvkvlRkkrpgavqteeqYvfiyeavlealdsfnd

subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 1116-1151 1.2e-07 26.2 In-house 249-284 (297) alignment
Range on Protein: 1116-1151
Range on HMM: 249-284/297.0
KLDIMNIVSRMREDRRFMVQTVDQYKFCYLASLEAA
..||...|...|..| ..||| .|||| | | ||| 
evdifglvkklrqerpylvqtkeqykfvyvavleal

DUF2959 Protein of unknown function (DUF2959) 483-546 3.5e-07 16.5 Pfam-A 28-91 (201) alignment
Range on Protein: 483-546
Range on HMM: 28-91/201.0
QRLEQAQEHLAGFQERFEAAAAKFESARKMASDRLRQEHDDMKSSLQQAQQAVRLARDKLEAIE
.|.|.|.|     .|.|. |  .|.|  .. .  | ...............| .  .......|
drvedaresqeeakeqfksaleqfkslvnfdggdlekkynelndeyeesesaaeevseridkve

subfamily_PTPRA_pd Subfamily PTPRA 1115-1149 3.5e-07 24.4 In-house 259-293 (330) alignment
Range on Protein: 1115-1149
Range on HMM: 259-293/330.0
GKLDIMNIVSRMREDRRFMVQTVDQYKFCYLASLE
.|.|. ..|.|.|  |  ||||  ||.|.| . ||
rkvdvfefvkrlrlqrpqmvqtdeqyefiykvlle

subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 1116-1151 6.6e-07 23.7 In-house 253-288 (325) alignment
Range on Protein: 1116-1151
Range on HMM: 253-288/325.0
KLDIMNIVSRMREDRRFMVQTVDQYKFCYLASLEAA
..||.. | ..|.||  ||.||||| ..| |  || 
rvdifgfvkklrkdrpsmvetvdqyiliyealveay

subfamily_PTPRK_pd Subfamily PTPRK 1115-1151 1.2e-06 22.6 In-house 241-277 (314) alignment
Range on Protein: 1115-1151
Range on HMM: 241-277/314.0
GKLDIMNIVSRMREDRRFMVQTVDQYKFCYLASLEAA
| .|. |.|  .|. .  ||.| .||||.| . |||.
gvvdvfnavktlrsrkvnmveteeqykfiydvileac

subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 1116-1155 1.4e-06 22.7 In-house 207-246 (250) alignment
Range on Protein: 1116-1155
Range on HMM: 207-246/250.0
KLDIMNIVSRMREDRRFMVQTVDQYKFCYLASLEAARRYN
..|..... ..|.||  .|.. .|| |.| . |.|   ..
vvdvfkvikvlrkdrphavesleqyvfvyeiilkaldsve

subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 1116-1150 2e-06 22.1 In-house 205-239 (239) alignment
Range on Protein: 1116-1150
Range on HMM: 205-239/239.0
KLDIMNIVSRMREDRRFMVQTVDQYKFCYLASLEA
 .||.| |  .|||| .|||| .|| | .|| |||
tvdifnyvkairedrphmvqtseqyvfihlavlea

subfamily_Sponge-PTP-4_pd Subfamily Sponge-PTP-4 882-965 3.3e-06 21.4 In-house 3-71 (130) alignment
Range on Protein: 882-965
Range on HMM: 3-71/130.0
LPYDRTRVHmqvlpgygsTDDYINACHVRSLTsGCPDFVCAQGPKHSTSGDFWKMVVQQRSRVIVMVTNLEERgrpkcDRYWPA
|... .|..          ..||||  |  |     ... .| |   || |||||....   |.|..  .||      | ||| 
lefevsrlq.........gntyinasfvGllg.rtaeylltqhpladtsmdfwkmmleryvnvlvvlgsveee.....deywpd

subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 1115-1150 4e-06 20.9 In-house 241-276 (315) alignment
Range on Protein: 1115-1150
Range on HMM: 241-276/315.0
GKLDIMNIVSRMREDRRFMVQTVDQYKFCYLASLEA
  .|..|.|  .|..| ..||| ..| | | | || 
rsvdvfnfvknlrakrpylvqteeeyafiydavled

subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 1114-1150 6.4e-06 19.5 In-house 239-275 (515) alignment
Range on Protein: 1114-1150
Range on HMM: 239-275/515.0
GGKLDIMNIVSRMREDRRFMVQTVDQYKFCYLASLEA
.  .|..|.|  .|..| ..||| .|| | | | || 
trmvdvfnfvtnirqkrpylvqtqeqyafiygavled

subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 1116-1149 7.6e-06 20.3 In-house 206-239 (239) alignment
Range on Protein: 1116-1149
Range on HMM: 206-239/239.0
KLDIMNIVSRMREDRRFMVQTVDQYKFCYLASLE
 .||.| |  .|||| .|||| .|| | .|| ||
tvdifnyvkairedrphmvqtseqyvfihlavle

subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 1113-1153 7.8e-06 20.1 In-house 226-266 (270) alignment
Range on Protein: 1113-1153
Range on HMM: 226-266/270.0
QGGKLDIMNIVSRMREDRRFMVQTVDQYKFCYLASLEAARR
. .|.|...|....|.||  .||...||.| | | .| |.|
etkkvdvlaiieelRkdRmalvqhpeqyeflykavveyaer