Gene PTPN3 in Monosiga brevicollis

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily PTPN3
Protein sequence
ID Type Fasta BLAST phosphatome Note
MbreP067_AA protein Get Run
MbreP067_AA_1754-1997 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_PTPN3_pd Subfamily PTPN3 1756-1998 6.5e-103 338.5 In-house 29-275 (280) alignment 
Range on Protein: 1756-1998
Range on HMM: 29-275/280.0
KSRDCSLALKPENAVRNRYRDILPYDDTRVKLDSSNNDYINANHLSFESNGTTFS--YIASQ------AKHFWQMVWEQQVRLICMLTTLVEGGRTKCHQ
.....| | ||||...||||||||||.|||||..|..||||||....|...|...  |||.|      |..||||||||...||.||||||| ||.||||
pglaisaarkpenlsknryrdilpydatrvklkesetdyinanyvnmeipstglvnryiatqGPlaktatdfWqmvweqksslivmlttlverGrvkChq

YWPSaPGDTCQFGDFSIVLNKEAARKGYILRDITVQRANAKGKRRLFQLQFTAWPDHGLPTSSAEMLTLVKEINNLKsrLVKPMPLLVHCSAGIGRTGVY
|||. ..|....|.||....||...| |.||.........| .|...|||..||||||.|..||..|..|.....|.   .| .|..||||||||||||.
yWPe.tedeleygefsvkcekedetksyvlrelvlkdketkeerkilqlqylaWpdhgvPddsadflefvervrklr..sgkeePvvvhCsaGigrtGvl

ILLELCLHqLQEKAKEVNIPAILSQLREQRMNLVQTQDQYKFVCGTVMALS
||||..|. |.|.|..|....|....|.||..||||..|||||| ......
illetala.lieaaepvypldivrtmrdqramlvqtasqykfvCeailkvy
0050432 (Phosphotyrosine protein) phosphatases II 1756-1994 2.7e-80 265.3 In-house 56-295 (308) alignment 
Range on Protein: 1756-1994
Range on HMM: 56-295/308.0
KSRDCSLALKPENAVRNRYRDILPYDDTRVKLdSSNNDYINANHLSFESNGTTFSYIASQA------KHFWQMVWEQQVRLICMLTTLVEGGRTKCHQYW
 ....| ||.|||  .|||.|||||| .|||| ....|||||.. .. |.. .  .|| |.      ..||.|||||.||.| |||.||| || ||.|||
plleysvallpenkdkNrykdilpydhsRVkl.degsdYInAsyvdgyssklprkfIatqgPlpntvedFwrmvweqnvrvIvmLtklvengrekcaqYw

PSAPG-DTCQFGDFSIVLNKEAARKGYILRDITVQRANAKGKRRLFQLQFTAWPDHGLPTSSAEMLTLVKEINNLKsrlvKPMPLLVHCSAGIGRTGVYI
|. .| .. ..|.|.. | .|  ...|..| ....  . .  |.. ....|.||||| |.| ...|........      .. | .||||||.||||..|
plelgggsleygkftvtllseevlddytvrtleltnlgdgesrtvthfhytnWpdhgvPpspeilldflelvrksl....pggpivVHCsaGvGRtGtfi

LLELCLHQLQEKaKEVNIPAILSQLREQRMNLVQTQDQYKFVCGTV
.|.|.|.||... ..|... .. .|||||.. ||| .||.|.. ..
aldllleqleke.ggvdvfeavkklReqRpgmvqtpeqylflyral
0036941 (Phosphotyrosine protein) phosphatases II 1756-1997 8.4e-77 253.7 In-house 27-276 (297) alignment 
Range on Protein: 1756-1997
Range on HMM: 27-276/297.0
KSRDCSLALKPENAVRNRYRDILPYDDTRVKLDSSNNDYINANHLsfESNGTTFSYIASQ------AKHFWQMVWEQQVRLICMLTTLVEGGRTKCHQYW
.. ..| ||.|||  .|||.||||||.||||||....|||||...  .  . .. .|| |        .||.|||||.|. | |||.||| || ||.|||
llgslsvallpenleknRykdilpydhtRVklddegsdYinAsyv..dgydlkrkfIatqgPlpntvedFWrmvweqnvtvIvmltelvelgrekcaqyw

PSAPGDTCQFGDFSIVLNKEAA--RKGYILRDITVQRANAKGKRRLFQLQFTAWPDHGLPTSSAEMLTLVKEINNLKSRLVKPMPLLVHCSAGIGRTGVY
|.  |.. ..|||.. | ..     ..|.|| ..|.  . . .|.. ....| |||||.|.| |..| .......  . | .. | |||||||.||.|..
pleegesltygdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfielvrkvlkllpsggpvlVHCsaGvgRsgtf

ILLELCLHQLQE--KAKEVNIPAILSQLREQRMNLVQTQDQYKFVCGTVMAL
|...|.|.||..  | ..|.|. .. .|||||.. ||| .||.|.. ... |
iaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallel
0046845 (Phosphotyrosine protein) phosphatases II 1756-1994 9.5e-77 253.5 In-house 16-270 (284) alignment 
Range on Protein: 1756-1994
Range on HMM: 16-270/284.0
KSRDCSLALKPENAVRNRYRDILPYDDTRVKLDS-----SNNDYINANHLSFESN---GTTFSYIASQA------KHFWQMVWEQQVRLICMLTTLVEGG
 . ..| ||.|||  .|||.||||||..||||.|     ...|||||..... .     ..  .|| |.      ..||.|||||.||.| |||.||| |
lllslsvallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweqnvrvIVmltelveng

RTKCHQYWPSApGDTCQFGDFSIVLNKEAARKGYILRDITVQRAN-AKGKRRLFQLQFTAWPDHGLPTSSAEMLTLVKEINNLKSRLVKPMPLLVHCSAG
|.||.||||.  |.. ..|||.. | .|  ...|..| ..... .  .  |.. ....|.||||| |.|.. .|........| ..| .. | .||||||
rekcaqYwple.gevltygdftvtllseevkddytvrtleltnlgytgesrtvthfhytswpdhgvppspedlleflrlvrellenlpgggpivVHCsaG

IGRTGVYILLELCLHQLQEKAK--EVNIPAILSQLREQRMNLVQTQDQYKFVCGTV
.||||..|.|.|.|.||...    .|... ....|||||.. ||| .||.||. ..
vgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyeal
subfamily_PTPRD_pd Subfamily PTPRD 1759-1994 2.1e-75 249.4 In-house 39-277 (564) alignment 
Range on Protein: 1759-1994
Range on HMM: 39-277/564.0
DCSLALKPENAVRNRYRDILPYDDTRVKLDSSNN----DYINANHLsfESNGTTFSYIASQA------KHFWQMVWEQQVRLICMLTTLVEGGRTKCHQY
 .. | ||.|  .||| .|..|| .||.| . ..    |||||...  ..  .  .|||.|.      . ||.|||||... | ||| |.| |..|||.|
tweaankpaNkaKNRyanivaYdhsRVvLskvegdegsDYINAsfi..dgyrkrkayIAtqgPlaetiedFWRmvweqnsstiVmltkleEkgkvkchkY

WPSApGdTCQFGDFSIVLNKEAARKGYILRDITVQRANAKGKRRLFQLQFTAWPDHGLPTSSAEMLTLVKEINNLKSrlVKPMPLLVHCSAGIGRTGVYI
||.  | |...|.. . |..|   . |..|........ . .|   | .||.||||| |.| ...|.|......|..   .  |..||||||.||||..|
WPek.g.tetygeltVtleeeeeladyeirtfklkkkkssesreVrqFhFtsWPdhgvpesatslLdlirkvralne..pdagPivVhCSaGVGRTGtfi

LLELCLHQLQEkAKEVNIPAILSQLREQRMNLVQTQDQYKFVCGTV
 .. .| ...|  | |.|  ....||.||  .|||..|| |.  ..
vidamlerike.ektvDiyqyvkalrkqRnamVqteeQYiFiheai
0047943 (Phosphotyrosine protein) phosphatases II 1755-1991 3.3e-75 248.4 In-house 25-265 (273) alignment 
Range on Protein: 1755-1991
Range on HMM: 25-265/273.0
VKSRDCSLALKPENAVRNRYRDILPYDDTRVKLDSSNNDYINANHLsfESNGTTFSYIASQA------KHFWQMVWEQQVRLICMLTTLVEGGRTKCHQY
 .. ..| ||.|||  .|||.||||||..||||.....|||||...  .   ..  .|| |.      ..||.|||||.||.| |||.||| || ||.||
kplltysvallpenkdknrykdilpydhsrvklgdggsdyinAsyv..dgynlkrkfiatqgPlpntvedfwrmvweqnvrviVmLtelvelgrekcaqY

WPSAPGD-TCQFGDFSIVLNKEAARKGYILRDITVQRANAKGKRRLFQLQFTAWPDHGLPTSSAEMLTLVKEINNLKSRLVKPMPLLVHCSAGIGRTGVY
||.  |. . ..|.|.. | .|  ...|..| ..... . . .|   ....| ||||| |.| ...|........  . |... | .||||||.||||..
wpleggelsltygkftvtllseetkddytvrtleltnlgtgesrtvthfhytgwpdhgvppslesllefielvrkalealpsngpvvVHCsaGvgRtgtf

ILLELCLHQLQEKaKEVNIPAILSQLREQRMNLVQTQDQYKFVC
|.|.|.|.||... ..|... .. .||.||.. ||| .||.|..
ialdllldqleke.ggvdvleavkllrsqRpgmvqtpeqyrfly
0051299 (Phosphotyrosine protein) phosphatases II 1756-1994 3.6e-75 248.4 In-house 37-282 (288) alignment 
Range on Protein: 1756-1994
Range on HMM: 37-282/288.0
KSRDCSLALKPENAVRNRYRDILPYDDTRVKLDS----SNNDYINANHLSFESNGTTfsYIASQA------KHFWQMVWEQQVRLICMLTTLVEGGRTKC
 ....| ||.|||  .|||.||||||..|||| .    ...|||||.....  .. .  .|| |.      ..||.|||||.||.| |||.||| ||.||
pdltlsaallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyidgynlkrk..fIatqgPlpntvedFWrmvweqnvrvIvmltklvelgrekc

HQYWPSapGDTCQFGDFSIVLNKEAARKGYILRDITVQRA----NAKGKRRLFQLQFTAWPDHGLPTSSAEMLTLVKEINNLKSrlVKPMPLLVHCSAGI
.||||.  |.. ..||... | .|   ..|..| ..|..       . .|.  ....|.||||| |.|  ..|........  .   .. | .||||||.
aqYwpl..ggsltygditvtllseevlddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpdspellldflrlvrkala..sgggpvvVHCsaGv

GRTGVYILLELCLHQLQEKaKEVNIPAILSQLREQRMNLVQTQDQYKFVCGTV
||||..|.|.|.|.||... ..|... .. .|||||...||| .||.||. ..
gRtgtfialdllleqleke.ggvdvleavkrlreqRpgmvqtpeqyrfvyeal
DSPc_SM00195 1758-1997 7.4e-72 237.2 In-house 16-261 (263) alignment 
Range on Protein: 1758-1997
Range on HMM: 16-261/263.0
RDCSLALKPENAVRNRYRDILPYDDTRVKLDSSN----NDYINANHLSFEsnGTTFSYIASQA------KHFWQMVWEQQVRLICMLTTLVEGGRTKCHQ
.... | |..|  .|||..|||||.|||||....    .||||||.....    . .||| |.      ..||.||||..|..|.|||  .| |..||..
ketteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikga..nkkkkyIatQgPlpstvedFWrmvweekvkiivmlteeeengkekcdr

YWPSAPGDTCQFGDFSIVLNKEAARK-GYILRDITVQRANAKGKRRLFQLQFTAWPDHGLPTSSAEMLTLVKEINNLKSRLvkPMPLLVHCSAGIGRTGV
|||.  |.. .||..|. | ..  .|  .|||.....  . . .|.. |.|...|||||.| |  ..| |...... ||.     |..||||||.||||.
ywpeesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkksksts..sgpivVhCsaGvgRtgt

YILLELCLHQLQEKAKeVNIPAILSQLREQRMNLVQTQDQYKFVCGTVMAL
.......|..|.|. | |.| .|...||.||...|||..||.|.. .....
fvtidiilskleeekk.vdifeivkelRkqRpgmvqtleqYlfiyeailey
PTPc_SM00194 1758-1997 7.4e-72 237.2 In-house 16-261 (263) alignment 
Range on Protein: 1758-1997
Range on HMM: 16-261/263.0
RDCSLALKPENAVRNRYRDILPYDDTRVKLDSSN----NDYINANHLSFEsnGTTFSYIASQA------KHFWQMVWEQQVRLICMLTTLVEGGRTKCHQ
.... | |..|  .|||..|||||.|||||....    .||||||.....    . .||| |.      ..||.||||..|..|.|||  .| |..||..
ketteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikga..nkkkkyIatQgPlpstvedFWrmvweekvkiivmlteeeengkekcdr

YWPSAPGDTCQFGDFSIVLNKEAARK-GYILRDITVQRANAKGKRRLFQLQFTAWPDHGLPTSSAEMLTLVKEINNLKSRLvkPMPLLVHCSAGIGRTGV
|||.  |.. .||..|. | ..  .|  .|||.....  . . .|.. |.|...|||||.| |  ..| |...... ||.     |..||||||.||||.
ywpeesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkksksts..sgpivVhCsaGvgRtgt

YILLELCLHQLQEKAKeVNIPAILSQLREQRMNLVQTQDQYKFVCGTVMAL
.......|..|.|. | |.| .|...||.||...|||..||.|.. .....
fvtidiilskleeekk.vdifeivkelRkqRpgmvqtleqYlfiyeailey
0040438 (Phosphotyrosine protein) phosphatases II 1757-1993 1.1e-71 237.1 In-house 33-271 (317) alignment 
Range on Protein: 1757-1993
Range on HMM: 33-271/317.0
SrDCSLALKPENAVRNRYRDILPYDDTRVKLDSSN----NDYINANHLSFESNGTTfsYIASQA------KHFWQMVWEQQVRLICMLTTLVEGGRTKCH
. ..| |..|||  .|||.||||||..|||| . .    .|||||.. .. . ...  .|| |.       .||.|||||.|..| |||.|.| || ||.
d.tysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyvdgpnlkrk..fIatqgPlpntvedFwrmvweqgvtvivmLteleelgrekca

QYWPSapGDTCQFGDFSIVLNKEAARKGYILRDITVQRANAKGKRRLFQLQFTAWPDHGLPTSSAEMLTLVKEINNLKSrlVKPMPLLVHCSAGIGRTGV
||||.  |.| ..|||.. | .|   .|..|| ..|.  . . .|.. ....|.|||||.| |  ..| .......  .   .. |.|||||||.||||.
qYwpl..getltygdftvtllseeelagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfleavreale..dpggpvlVHCsaGvgRtGt

YILLELCLHQLqEKAKEVNIPAILSQLREQRMNLVQTQDQYKFVCGT
.|...|.|.|| || ..|... .. .|||||.. ||| .||.|..  
fiaaylmleql.ekeggvdveeavkelreqRpgavqtpeqyrflyda
subfamily_PTPRB_pd Subfamily PTPRB 1755-1999 1.3e-70 232.8 In-house 38-286 (293) alignment 
Range on Protein: 1755-1999
Range on HMM: 38-286/293.0
VKSRDCSLALKPENAVRNRYRDILPYDDTRVKL----DSSNNDYINANHLSFESngTTFSYIASQ------AKHFWQMVWEQQVRLICMLTTLVEGGRTK
 |.. .. | ...|. .|||..||||| .||||    |.|..||||||...  .  ..  .||.|       ..||.||||.... | ||| |||.|..|
gkdqavkaaelavnraknrytnilpydhsrvkLaalkdesgsDYinanyipgyn..sprefiatqGPlpetvddfWrmvwekkssiivmltqlvekgkvk

CHQYWPSAPgDTCQFGDFSIVLNKEAARKGYILRDITVQRanAKGKRRLFQLQFTAWPDHGLPTSSAEMLTLVKEINNLKSRLVKPMPLLVHCSAGIGRT
|..|||.   .....|| .. |..|   . ...|......  .| .|.. |..||.||||| | ... .|..|..... ...  .  |..||||||.|||
CeeYWPade.epvlyGdikvtlvaeeeledwvirelkiek..ekeerkvrqyhftsWpdhgvPektktlldfvrtvreaiektaskrPivvhCsaGvGRt

GVYILLELCLHQLQEkAKEVNIPAILSQLREQRMNLVQTQDQYKFVCGTVMALSK
|..| |.  |....|    |.| .|...|||.|..||||..|| |.  .|..| .
Gtfialdrllqaiee.edyvdifgivaelReeRnllvqtekqYifihqcvldllr
0045450 (Phosphotyrosine protein) phosphatases II 1757-1991 1.4e-70 233.8 In-house 44-297 (307) alignment 
Range on Protein: 1757-1991
Range on HMM: 44-297/307.0
SRDCSLALKPENAVRNRYRDILPYDDTRVKLDS-----SNNDYINANHLSF------ESNGTTFSYIASQ------AKHFWQMVWEQQVRLICMLTTLVE
. ..| ||.|||  .|||.||||||.||||| |     ...|||||..  .      ..   .  .|| |       ..||.|.|||.|..|.|||.|||
lgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydlkrkfIatqgPlpetvedFwrmlweqgvtvivmltelve

GGRTKCHQYWPSApGDTCQFGDFSIVLNKEAARKGYILRDITVQRA-NAKGKRRLFQLQFTAWPDHGLPTSSAEMLTLVKEINNLKSRLVKPMPLLVHCS
 || ||.||||.  |.. ..|.| . | .|   .||..| ..|..    .  |.. ....|.|||||.|.| .|.| ...|...  ..| |. | |||||
lgrekcaqywPde.geeltygnftvtllseehldgytvrtlevtdldgtgesrtvthfhytgwpdhgvppsfeelldfieevrkaleelpkggpvlVHCs

AGIGRTGVYILLELCLHQLQEKAKE--VNIPAILSQLREQRMNLVQTQDQYKFVC
||.||||..|.. |.|.||..  .   |... ....|||||.. ||...||.|..
aGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrfly
Y_phosphatase Protein-tyrosine phosphatase 1768-1994 2.8e-69 228.5 Pfam-A 1-233 (235) alignment 
Range on Protein: 1768-1994
Range on HMM: 1-233/235.0
NAVRNRYRDILPYDDTRVKL--DSSNNDYINANHLSFESNgtTFSYIASQAK------HFWQMVWEQQVRLICMLTTLVEGGRTKCHQYWPSAPGDTCQF
|  .|||.||||||.|||||  .....||||||...  ..  ....||.|.       .||.|||...|..| |||.|.| ||.||.||||.. ......
nkkknRykdilpydktrvklkgsegpsdYInAnyvkgyke..kkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeeslty

GDFSIVLN-KEA-ARKGYILRDITVQRANAK-GKRRLFQLQFTAWPDHGLPTSSAEMLTLVKEINNLKsrLVKPMPLLVHCSAGIGRTGVYILLELCLHQ
||... |  ||  . |.|.||.....  ...  ||.. ||..|.|||||.|.|. ..| |...... |    |  |..||||||.||||....|...|.|
gdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkveksk..eaksgpvvVhCsaGvgRtgtfvaldilleq

LQEKAKeVNIPAILSQLREQRMNLVQTQDQYKFVCGTV
|... . |..  |...||.||...||. .||.|.. ..
leaeee.vdvlqivkelRkqRpgmvqsleqYiflykai
Y_phosphatase Protein-tyrosine phosphatase 1768-1994 2.8e-69 228.5 In-house 1-233 (235) alignment 
Range on Protein: 1768-1994
Range on HMM: 1-233/235.0
NAVRNRYRDILPYDDTRVKL--DSSNNDYINANHLSFESNgtTFSYIASQAK------HFWQMVWEQQVRLICMLTTLVEGGRTKCHQYWPSAPGDTCQF
|  .|||.||||||.|||||  .....||||||...  ..  ....||.|.       .||.|||...|..| |||.|.| ||.||.||||.. ......
nkkknRykdilpydktrvklkgsegpsdYInAnyvkgyke..kkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeeslty

GDFSIVLN-KEA-ARKGYILRDITVQRANAK-GKRRLFQLQFTAWPDHGLPTSSAEMLTLVKEINNLKsrLVKPMPLLVHCSAGIGRTGVYILLELCLHQ
||... |  ||  . |.|.||.....  ...  ||.. ||..|.|||||.|.|. ..| |...... |    |  |..||||||.||||....|...|.|
gdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkveksk..eaksgpvvVhCsaGvgRtgtfvaldilleq

LQEKAKeVNIPAILSQLREQRMNLVQTQDQYKFVCGTV
|... . |..  |...||.||...||. .||.|.. ..
leaeee.vdvlqivkelRkqRpgmvqsleqYiflykai
subfamily_PTPN13_pd Subfamily PTPN13 1758-1995 4.5e-69 227.8 In-house 27-266 (273) alignment 
Range on Protein: 1758-1995
Range on HMM: 27-266/273.0
RDCSLALKPENAVRNRYRDILPYDDTRVKLDSSNNdYINANHLSFESNGTTFSYIASQ------AKHFWQMVWEQQVRLICMLTTLVEGGRTKCHQYWPS
 .|. . | ||  .||||..||||.|||||... . ||||...  . .  ...|||.|      .| ||||||||....| |.|. .|.|. |||.|||.
dtcevgkkkenkdknryrnvlPydetrvklgdegg.yinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweqkaeviamvtlekekgkvkchrywPe

APGDTCQFGD-FSIVLNKEAARKGYILRDITVQRANAKGKRRLFQLQFTAWPDHGLPTSSAEMLTLVKEINNLKSrlvKPMPLLVHCSAGIGRTGVYILL
  ... .  . . . | |   ..|. .|...|.  ...  |.. .|.|..||||| |.|.||.|..|.|...|..   .  |..|||||||||.|..| .
sknkklkvsnrlevellkvqkldgfvvralavkdsesgesrevahlnfvkwPdhgvPssaaellqfvaevrrlqt...dagPivvhcsaGiGrsGtliti

ELCLHqLQEKAKEVNIPAILSQLREQRMNLVQTQDQYKFVCGTVM
.  |  | |. ||...  |. .|||||  .|||.||| ||  ...
dvvlg.lierdkefdvkeivrklreqrqgvvqtkdqyifvykail
0039614 (Phosphotyrosine protein) phosphatases II 1758-1992 4.7e-69 228.4 In-house 46-283 (297) alignment 
Range on Protein: 1758-1992
Range on HMM: 46-283/297.0
RDCSLALKPENAVRNRYRDILPYDDTRVKLDS-----SNNDYINANHLSFESNgTTFSYIASQA------KHFWQMVWEQQVRLICMLTTLVEGGRtKCH
 |.| ||.|||  .|||.||||||..|||| .      ..|||||..... .  .|  .||.|.      ..||.|||||.|. | |||.||| || ||.
pdysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydl.ltrkfIatqgPlpetvedFwrmvweqgvtvivmLtklvelgr.kca

QYWPSAPGdtcQFGDFSIVLNKEAARKGYILRDITVQRanAKGKRRLFQLQFTAWPDHGLPTSSAEMLTLVKEINNLKSRLVKPMPLLVHCSAGIGRTGV
||||.  |   ..|||.. | |.  ..||..| ..|..   .  | . ..|.| ||||| | |.. .| .......  ..| |. | |||||||.||||.
qywpeegg...tygdftvtllkvehldgytvrtlevtn..ngesrtvthfqytgwpdhgvppslellleflelvrealaelpkggpvlVHCsaGvgRtGt

YILLELCLHQLQEKaKEVNIPAILSQLREQRMNLVQTQDQYKFVCG
.|.. |.|.||... ..|... ....|||||.. ||| .||.|.. 
fiaaylmleqleke.ggvdvleavkelreqRpgavqtpsqyrflyd
subfamily_PTPN6_pd Subfamily PTPN6 1763-1994 1.6e-68 226.0 In-house 49-293 (306) alignment 
Range on Protein: 1763-1994
Range on HMM: 49-293/306.0
ALKPENAVRNRYRDILPYDDTRVKL---DSSNNDYINANHLSFESNGTTFSYIASQAKH------FWQMVWEQQVRLICMLTTLVEGGRTKCHQYWPSAP
. ||||. .|||. |||.|.|||.|   . ...|||||| .. |..|.. ||||.|         ||.|||... |.| |.|. || |. || .|||.. 
gakpenkeknryknilPfDhtrvilkepsvpgsdyinanyikkevkgsdksyiatqgclettvsdFWrmvwqensrvivmttkevErgkekCarYWPdee

GDTCqFGDFSIVLNKEAARKGYILRDITVQR-ANAKGKRRLFQLQFTAWPDHGLPTSSAEMLTLVKEINNLKSRLV--KPMPLLVHCSAGIGRTGVYILL
 ..  .|. |.   .| . . ||||...|..  ..| .|..||..|..||||| |..   .| .....|. ...|   .. |..||||||||||| .|..
ekee.yGkisvtnvseksladYilRelsvskkkkkkeerevfqyhfksWPdhgvpkdpgavLdfledvnrkqeeleeaeagpivvhCsaGiGRtGtfivi

ELCLHQLQEKAK--EVNIPAILSQLREQRMNLVQTQDQYKFVCGTV
.. |.....|    ...|  .  ..||||  ||||..|||||  ..
Dillkliekkgldadidiqklvksvreqrsglvqteqqykfvykai
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 1761-1995 3.4e-68 224.8 In-house 33-273 (281) alignment 
Range on Protein: 1761-1995
Range on HMM: 33-273/281.0
SLAL-KPENAVRNRYRDILPYDDTRVKL----DSSNNDYINANHLSfeSNGTTFSYIASQA------KHFWQMVWEQQVRLICMLTTLVEGGRTKCHQYW
. |  ..|| ..|||..|  || ||||.    ...|.||||||...  .      |||.|.      ..||||||||.|..| |.|  .|.|. |||.||
ataskadenvlknrYsnivaYDatrvkvtpneenkntDYinanfvp..gykgekeyiatqgPvPaslvafWqmvweqkvsaivmvtreieagklkChrYW

PsAPGDTCQFGDFSIVLNKEAARKGYILRDITVQRANaKGKRRLFQLQFTAWPDHGLPTSSAEMLTLVKEINNLKSRLVKpMPLLVHCSAGIGRTGVYIL
|  .  . ..||. .  ..|.... || | ....| .   .|.. ||..||||||| |....|.|   ||...|...  | .||..|||||.||||.|| 
P.ddnselkygdvtvkstaeeekatyierkfkleres.getreveqlaytaWPdhGvPattkellefrkevlkltekktk.aplvihCsaGvGrtGtyia

LELCLHQLQEKAKEVNIPAILSQLREQRMNLVQTQDQYKFVCGTVM
|.  .........|... |.. .||..|. .|||  ||.||  .|.
lDrlvkaveaeleeldvkavvaelrkernlmvqtvvqyefvykavl
0043336 (Phosphotyrosine protein) phosphatases II 1758-1992 4.2e-68 225.1 In-house 35-271 (278) alignment 
Range on Protein: 1758-1992
Range on HMM: 35-271/278.0
RDCSLALKPENAVRNRYRDILPYDDTRVKLDSSN----NDYINANHLsfESNGTTFSYIASQ------AKHFWQMVWEQQVRLICMLTTLVEGGRTKCHQ
 ..| ||.|||  .|||.|||||| .||||.. .    .|||||...  .    .  .||.|       ..||.||||..|. | |||.||| ||.||.|
dtysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyv..dgynvprkfiatqgPlpetvedFwrmvwelgvttivmLtelvelgrvkcaq

YWPsapGDTCQFGDFSIVLNKEAARKGYILRDITVQRANAKGKRRLFQLQFTAWPDHGLPTSSAEMLTLVKEINNLKSrlVKPMPLLVHCSAGIGRTGVY
|||   |.. ..|||.. | ||   ..|..|...| .   . .|   ......|||||.|.| . .| ..|....  .   .. |.|||||||.||||..
Ywp...ggsltygdftvtllkeehlddytvrtlevtnlgdgesrtvthyhylgwpdhgvpeslsllldflkavreale..dsngpvlVHCsaGvgRTGtf

ILLELCLHQLqEKAKEVNIPAILSQLREQRMNLVQTQDQYKFVCG
|.|.|.|.|| || ..|... ....|||||.. |||..||.|.. 
ialyllleql.ekeggvdleeavkelreqRpgavqtpsqyrflye
subfamily_PTPN12_pd Subfamily PTPN12 1761-1997 1.4e-67 222.7 In-house 33-276 (290) alignment 
Range on Protein: 1761-1997
Range on HMM: 33-276/290.0
SLALKPENAVRNRYRDILPYDDTRVKLDSS----NNDYINANHLSFESNgtTFSYIASQA------KHFWQMVWEQQVRLICMLTTLVEGGRTKCHQYWP
. . |.||  .|||.|||||| .||.|       ..||||||..   ..  . .|||.|.      . ||.|.||..|... |.  .|| |..||..|||
eagekeenvkknrykDilPydksrvelskieeeegsdYinanfikgveg..kleyiaaqgPLpktlddfWrmiweknveivvmaCrevelgkkkCerYWp

SAPGDTCQFGDFSIVLNKEAARK-GYILRDITVQRAnaKGKRRLFQLQFTAWPDHGLPTSSAEMLTLVKEINNLKSrlVKPMPLLVHCSAGIGRTGVYIL
.  .....||.|.. |..| | . ....| ..|..   | .|.. |...||||||| |.|  ..| |......|..   . .||.||||||.||||. | 
eegeeelefgefevtleeekavdddflirtLkveaq..kesrkvyqfhYtaWPDhgvPssaksllelielvrelqe..sedaPlvvhCsaGvGrtGtiia

LELCLHQLQEKAK--EVNIPAILSQLREQRMNLVQTQDQYKFVCGTVMAL
...  ..|...    |...  .. .||.||  ||||..||..|  .|. |
idyvrellkaekipeeldvfdlvlelrkqraalvqtkeqyelvykavael
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 1755-1998 2.8e-67 221.8 In-house 34-279 (288) alignment 
Range on Protein: 1755-1998
Range on HMM: 34-279/288.0
VKSRDCSLALKPENAVRNRYRDILPYDDTRVKLDS----SNNDYINANHLSfeSNGTTFSYIASQA------KHFWQMVWEQQVRLICMLTTLVEGGRTK
 |... . . ...|| .||||.||||| .||||.     ...|||||...   ... .  |||.|.      ..||..|.|...  | ||| |||||.||
ektksvtagrlavnakknRyrnilpyDekrvklkkleeeagaDYinasyid..gekkkkkyiatqgPladtvndfWelvyenktstivmltelveggktk

CHQYWPSApGDTCQFGDFSIVLNKEAARKGYILRDITVQraNAKGKRRLFQLQFTAWPDHGLPTSSAEMLTLVKEINNLKSRLvkPMPLLVHCSAGIGRT
|..|||.| ..  ..|.. ..| ..   . ..|| . ..    |..... |.|..|||||| | |.|..| |.. ... ..      |..||||||.|||
CeeYWPda.dkpknyGsvtvtlveskeledfvlrkllle..kkkteleitqyqylaWpdhgvPeskapllellrqvkvanqad..tgpiivhCsaGvGrt

GVYILLELCLHQLQEkAKEVNIPAILSQLREQRMNLVQTQDQYKFVCGTVMALS
|..| |.  .....|  . ... .....||.||..||||. || |.  ... | 
gtFialdalidavee.edyiDvagtvaklRkqRallvqtlkqYefiyevllsli
0045098 (Phosphotyrosine protein) phosphatases II 1759-1991 3.4e-67 222.0 In-house 24-265 (278) alignment 
Range on Protein: 1759-1991
Range on HMM: 24-265/278.0
DCSLALKPENAVRNRYRDILPYDDTRVKldssnnDYINANHLSFEsngtTFSYIASQ------AKHFWQMVWEQQVRLICMLTTLVEGGRTKCHQYWPSa
... ||...|. .|||.|||||| .|||      |||||.....     .. .|| |      . .||.|.||.... |.|||.|||.|| ||.||||. 
eitpalylgnldknRykdilpydhsrVk......dYINAsyidgy....pkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrekcaqywpe.

pGDTCQFGDFSIVLNKEAARKGYILRDITVQRA----NAKGKRRLFQLQFTAWPDHGLPTSS--AEMLTLVKEINNLKSR-----------LVKPMPLLV
 |.. ..|||.. | .|   . |.||...|.      .   .| ...|... ||||| |...  . .| |...|..  ..           | .. | ||
.ggsltygdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsggpvlV

HCSAGIGRTGVYILLELCLHQLqEkaKEVNIPAILSQLREQRMN-LVQTQDQYKFVC
|||||.||||..... |.|..| |  . |... ....||.||..  ||...||.|..
HCsaGvgRtGtlvaaylmlell.e..ggvdlleavkelrsqRpglavqnleqyrfly
subfamily_PTPN14_pd Subfamily PTPN14 1758-1995 1e-66 220.0 In-house 39-293 (300) alignment 
Range on Protein: 1758-1995
Range on HMM: 39-293/300.0
RDCSLALKPENAVRNRYRDILPYDDTRVKLDSS---NNDYINANHLSFESNGTTFSYIASQA------KHFWQMVWEQQVRLICMLTTLVEGGRTKCHQY
 ..| |  |||| .||..|.|||.|.||.| ..   ...|||| ...    |.. |||..|.      . ||||||||.|.|| |||   |.|..|...|
allstaklpenaeknrfkdvlPyednrvelsptkenstgyinassikvsvggkersyivaqgPleltvqdfWqmvWeqgvqlivmlteeeedgkeksfky

WPSA--PGDTCQFGDFSIVLNKEAARKGYILRDITVQRANAKGKRRLFQLQFTAWPDHGLPTSSAEMLTLVKEINNLKSRLVKPM-------PLLVHCSA
.|.     .| .|| | .. .     . .| . ....   .| .| .. ||.| |||||.|    ..|  ..|.. .. .  . .       |.||||||
fPkleskkktvefgkfkvttkfsedsdsvittglklkhlpskeertvwhlqytDWpdhgvPeDvkgflsyLeevqsvrrktnseveskeskPPvlvhCsa

GIGRTGVYILLELCLHQLQeKAKEVNIPAILSQLREQRMNLVQTQDQYKFVCGTVM
|.||||| || .| .. |. . .|..|. .|..|||||| ||||  |||||  ...
GvGrtGvlilsdlliatle.hneeidikkvlarLreqrmllvqtlaqYkfvYkvli
0040439 (Phosphotyrosine protein) phosphatases II 1759-1991 3.3e-66 218.7 In-house 2-239 (249) alignment 
Range on Protein: 1759-1991
Range on HMM: 2-239/249.0
DCSLALKPENAVRNRYRDILPYDDTRVKLDSSN----NDYINANHLSFESNGTTfsYIASQA------KHFWQMVWEQQVRLICMLTTLVEGGRTKCHQY
..| ||.|||  .|||.|||||| .|||| . .    .|||||.....   ...  .|| |.      ..||.|.||.... |.|||.||| || ||.||
eysvallpenkdknrypdilpydhsrvklsilpglflsdyinAsyidgyyikrr..fiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqy

WPSapGDTCQFGDFSIVLNKEAARKGYILRDITVQRANAKGKRRLFQLQFTAWPDHGLPTSSAEMLTLVKEINNLKSRLVKPMPLLVHCSAGIGRTGVYI
||.  |.. ..|||.. | ..   ..|..| .....   . .|.  ..|.| |||||.| | ...| .......  ..| |. |.|||||||.||||..|
wpl..ggsleygdftvtllsvevkddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfi

LLELCLHQLQeKAKEVNIPAILSQLREQRMNLVQTQDQYKFVC
.. |.|.||. | ..|... ....||.||.. ||...||.|..
aaylmleqle.kelgvdleeavkllrsqRpgavqnpeqyrfly
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 1763-1995 6.8e-66 217.5 In-house 41-277 (318) alignment 
Range on Protein: 1763-1995
Range on HMM: 41-277/318.0
ALKPENAVRNRYRDILPYDDTRVKLDS----SNNDYINANHLSfeSNGTTFSYIASQA------KHFWQMVWEQQVRLICMLTTLVEGGRTKCHQYWPSA
.|.| |. .||| .||.||.|||||.      . ||||||..    .  . .|||.||      . ||.|||||. ..| ||| ..| |..|.|.|||| 
slepvnkaknryanilaydhtrvkLqmlegeegsDyinanyid..GyrrkkayiaaqaPlpetieDfWrmvWeqnsavivmltqeeergkakvhryWPsk

pgDTCQFGDFSIVLNKEAARKGYILRDITVQRANAKGKRRLFQLQFTAWPDHGLPTSSAEMLTLVKEINNLKSRLvKPMPLLVHCSAGIGRTGVYILLEL
  .. ..|.  . |..|   . |.|| ..|.| . . .|   | ..|.|||.|.|.|.|..| ||..... . .  .  |..||||||.|||||.| .. 
..gsrsygklvvelkeevelsdyvlrefkvtrteeeesrqvrqyhytsWpdegvpesgaslldlvrqvskaqqks.gagpivvhCsaGvGrtGvfiavdi

CLHQLQEKAkEVNIPAILSQLREQRMNLVQTQDQYKFVCGTVM
 |..... |  |..  . .||||||  .|||.|||.|.  ...
llerikaea.lvDvfqtvkqlreqrnlmvqtedqyefiydvll
0037934 (Phosphotyrosine protein) phosphatases II 1759-1991 9.6e-66 217.1 In-house 1-235 (243) alignment 
Range on Protein: 1759-1991
Range on HMM: 1-235/243.0
DCSLALKPENAVRNRYRDILPYDDTRVKLDSsnNDYINANHLSFESngttfSYIASQA------KH----FWQMVWEQQVRLICMLTTLVEGGRTKCHQY
..| ||.|||  .|||.||||||..||||..  .||||||.           .||.|.      ..    ||.|.||.... |.|||.||| || ||.||
sfsiallpenlsknrysdilpydhsrvkleg..sdyinanliyvtp.....rliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqy

WPsapGDTcQFGDFSIVLNKEAARKGYILRDITVQRAN-AKGKRRLFQLQFTAWPDHGLPTSSAEMLTLVKEINNLKSR------LVKPMPLLVHCSAGI
||   |.. ..|||.. | .|   ..|..| ..... .  . .|  .......||||| |.| . .| ...|...  ..      | .  |.|||||||.
wp...gev.tygdftvtllseehlddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGv

GRTGVYILLELCLHQLqekakEVNIPAILSQLREQRMN-LVQTQDQYKFVC
||||..|.. |.|..|     .|..  .. .|||||..  |||..||.|. 
gRtGtliaaylmllll.....gvdleeavkllreqRpgkavqtpsqyrfly
0042113 (Phosphotyrosine protein) phosphatases II 1760-1991 1.3e-64 213.3 In-house 1-236 (245) alignment 
Range on Protein: 1760-1991
Range on HMM: 1-236/245.0
CSLALKPENAVRNRYRDILPYDDTRVKLDSSN----NDYINANHLsfESNGTTFSYIASQA------KHFWQMVWEQQVRLICMLTTLVEGGRTKCHQYW
.| ||.|||  .|||.||||||.||||| . .    .|||||..        |  .||.|.      ..||.|.||.... |.|||...| || ||.|||
ysvallpenkdknrysdilpydhtrvklspdggdldsdyinasyv..dgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqyw

PSapGDTCQFGDFSIVLNKEAARKGYILRDITVQRANAKGKRRLFQLQFTAWPDHGLPTSSAEMLTLVKEINNLKSRlVKPMPLLVHCSAGIGRTGVYIL
|.  |.. ..|||.. | .|   ..|..| ..|..   . .|  ...... ||||| |.... .| .......  ..  .. |.|||||||.||||..|.
pl..gesltygdftvtllseehlddytvrtlevtnlgddesrevihyhylpwpdhgvpdllellldflefvrkalae.dsngpvlVHCsaGvgRtGtfia

LELCLHQLqEKAKEVNIPAILSQLREQRMNLVQTQDQYKFVC
. |.|.|| || ..|... .. .||.||.. |||..||.|. 
aylmleql.ekelgvsleeavkelrsqRpgavqtpsqyrfly
subfamily_PTPN23_pd Subfamily PTPN23 1757-1995 3.6e-63 208.1 In-house 32-277 (288) alignment 
Range on Protein: 1757-1995
Range on HMM: 32-277/288.0
SRDCSLALKPENAVRNRYRDILPYDDTRVKLDSSNNDYINANHLSFESNgTTFSYIASQA------KHFWQMVWEQQVRLICMLTTLVEGGRTKCHQYWP
.|. |.|.   .. .||.||||||| .||||..|..||||| ..   |  .. ..||.||        ||.||.||....| ||..  | |..|...|||
arkrsiaiaklyseknrsrdilPyDhnRvklrgskDDYinAsfvkdlsp.gcPdfiatqaPlqstlnDFWlmvyeqkssviVmllskeelgkpkvdrYwP

SAPGDTCQFGDFSIVLNKEAARKGYILRDITVQRANAKGKRRLFQLQFTAWPDHGLPTSSAEMLTLVKEINN--LKSRLVKPMPLLVHCSAGIGRTGVYI
.. |.| .|||.|. |...   . .. |.....  .|. .. .  ||.|.||..|.| |  ..| ...|...   . .    .||.||||||.|||||. 
edkgetvkfgdlsvtlksvretethvervlkletldadavksvshlqltsWpelGvPasPetllqfldevesayeavqrksktPlvvhCsaGvgRtgvfa

LLELCLHQLQEKAKEVNIPAILSQLREQRMNLVQTQDQYKFVCGTVM
|.   ...|...   ..|. ..|.||||| . ||...|.||.   |.
lvyaavrelekgnglldiiqvvsrlreqRrfmvqekeqlkfsyeavl
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 1760-1992 2e-62 206.1 In-house 38-277 (305) alignment 
Range on Protein: 1760-1992
Range on HMM: 38-277/305.0
CSLALKPENAVRNRYRDILPYDDTRVKLDS--SNN--DYINANHLSFESNGT----TFSYIASQAKHFWQMVWEQQVRLICMLTTLVEGGRTKCHQYWPS
. .  | .|. .||...| ..|| |..|    |..  |||||...   ..      . . . .  . ||....| .|. | ||| |||||. ||.|||| 
idvgkkeankaknrlkeitlldddriiltekeslddsdyinasyvdgykrkkkyivaqgPlkntvadfWrliveekvstivmltklveggkdkCrqYWpe

APGDTCQFGDFSIVLNKEAARKGYILRDITVQR-ANAKGKRRLFQLQFTAWPDHGLPTSSAEMLTLVKEINNLKSRlVKPMPLLVHCSAGIGRTGVYILL
. ... .||.||. |. |.. ..|| |....    . | .| . |.|.| ||||| |.... .|.|.|.... ...  | .|||||||||.|||||.| .
sktekkefgefsvelksektasdyieRklkisiededkesrtvlqyqltdWPdhGvpqfatsllslikrvqkdqkk.dkgvpllVhCsagvgRtGvfiav

ELCLHQLQeKAKEVNIPAILSQLREQRMNLVQTQDQYKFVCG
.. | .|. | ..|..  .| |||..||..|||.||| |.  
dialerlk.kEevvdvfevlkqlRskrmkmvqtldqYvflhd
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 1767-1996 2.2e-59 195.7 In-house 19-262 (270) alignment 
Range on Protein: 1767-1996
Range on HMM: 19-262/270.0
ENAVRNRYRDILPYDDTRVKLDSSNND----YINANHLS-FESNGTTfsYIASQA------KHFWQMVWEQQVRLICMLTTLVEGGRTKCHQYWPSAPGD
 ... |||.||||   |||.|.. ..|    |||||..  |... ..  |||...      |.||.|.||..|. | |.| |.| ||.|| .|||. |..
rgkklnRyadiLPsPatRvrleeleedsataYinAnyvrGfdgekkk..YiaamgPlpttlksfwrmiweekvtaivmttgleEkgrkkCerYWpaepke

--TCQFGDFSIVLNKEAARKGYILRDITVQraNAKGKRRLFQLQFTAWPDHGLPTSSA------EMLTLVKEINNLKSRLVKPMPLLVHCSAGIGRTGVY
  ....|. ...  .|. ..||||. ....  .   .|||   ....||||| |...       ..|...... . ...| |  |||||||||.||||. 
kvkledgkikvlalseekeegyiltrlrle..ekgeerrlvHfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkaePllvHcsaGvgRtGtl

ILLELCLHQLQEKaKEVNIPAILSQLREQRMNLVQTQDQYKFVCGTVMA
|.|. ... |.|. |.|.. ||...||..||.|||. .||.|.  .|. 
ialDiavrlLeet.kkvdvlaiieelRkdRmalvqhpeqyeflykavve
subfamily_PTPN1_pd Subfamily PTPN1 1759-1995 9e-59 193.6 In-house 23-268 (290) alignment 
Range on Protein: 1759-1995
Range on HMM: 23-268/290.0
DCSLALKPENAVRNRYRDILPYDDTRVKLDSSNNDYINANHLSFESNGTtfSYIAS------QAKHFWQMVWEQQVRLICMLTTLVEGGRTKCHQYWPSA
... | .|||  .|||||. ||| .|.||....||||||. . .|      ||| .       ..|||||||||. . . ||  .|| ...||.||||. 
ptreaklpenrnlnryrdvspydhsrikleradndyinaslveleeakr..syiltqGPlpntvdhfWqmvWeqkskavvmlnkvvekeqikcaqywPqg

PG-DTCQFG--DFSIVLNKEAARKGYILRDITVQRANAKGKRRLFQLQFTAWPDHGLPTSSAEMLTLVKEINNLKSRLVKPMPLLVHCSAGIGRTGVYIL
   .. ..    ... | .|  .. |..| . ..  ...  | ...  .|.||| |.| | | .| .. .. .  |   .  | ..||||||||.| ..|
eeekellledtklkvkliseerksyytvrllelenlktqetreilhfhyttwpdfgvpespaaflkflfkvresGslssdvGpavihcsaGiGrsGtfcl

LELCLHQLQEKAK--EVNIPAILSQLREQRMNLVQTQDQYKFVCGTVM
.. || ....| .   |.|   | .||..|. |.||.|| .|   ...
vdtclvliekkddlssvdikkvllelrkyrlGliqtadqlrfsylail
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 1755-1995 9.9e-59 194.0 In-house 43-287 (298) alignment 
Range on Protein: 1755-1995
Range on HMM: 43-287/298.0
VKSRDCSLALKPENAVRNRYRDILPYDDTRVKLDS----SNNDYINANHLSfESNGTTfSYIASQA------KHFWQMVWEQQVRLICMLTTLVEGGRTK
...   . | ||||  .||| ||...| .|| | .     . ||||| .|.   .|.. ..||.||      . ||.||.|...  | |||.|.| ..||
ieeeekevarkpenkkkNRyadiialdssRvvLekedadeesdYiNAsflh.aykgrn.afiatqaPltetvedFWrmvteedigtiVmltnleeldktk

CHQYWPSApgDTCQFGDFSIVLNKEAARKGYILRDITVQRANAKGKRRLFQLQFTAWPDHGLPTSSAEMLTLVKEINNlKSRLVKPMPLLVHCSAGIGRT
.|.|||.    . ..|.... | ..     .| | ..|.... ...|.. ||.|| |||.| |. .  .|.|.....  . .  .  |..|.||||.||.
yhkywPde..gketygeitvsllskeefadlivrklkvskkkeekerevrqlhftsWpdkgvpenatsvldllrkvra.sqqqagnkpvivqCsaGvgRs

GVYILLELCLHQLQeKAKEVNIPAILSQLREQRMNLVQTQDQYKFVCGTVM
| .| ..  | ... | . | .  ..  ||..|...|||..||.|.   |.
Gtfiaidsvlervk.keqvvDvfqvvkvlRkkrpgavqteeqYvfiyeavl
subfamily_PTPN9_pd Subfamily PTPN9 1764-1995 7.9e-58 190.8 In-house 38-287 (297) alignment 
Range on Protein: 1764-1995
Range on HMM: 38-287/297.0
LKPENAVRNRYRDILPYDDTRVKLDSSN----NDYINANHLSFESNG----TTFSYIASQAKHFWQMVWEQQVRLICMLTTLVEGGRTKCHQYWPSAPGD
 .. |  .||| |.| ||.|||.| . .     ||||||..    .     .|   .    . ||.|||||.|. | | | .|| || || ||||.  ..
klranleknrytdvlcydetrvvlakvdedeasdyinanfvdGykqkkafiatqGplkktvsdfWrmvWeqevlvivmttrvvergrlkcgqyWpleees

TCQFGDFSIVLNKEAARKGYILRDITVQRANAKGKRRLFQLQFTAWPDHGLPTSSAEMLTLVKEINNLKSRLVKPM-----------PLLVHCSAGIGRT
. .|||.|.   .   .. |  | ....... . .|..   ||..|||.| | |.|..| ..... . .. .|| .           |..||||||||||
saefgdlsvsnveveeeedykvrvleiknvkteesrkvthfqflsWPdyGvPssaaslldvlekvrekqalavkelgdewkghpsgPPivvhcsaGiGrt

GVYILLELCLHQLQEKAKeVNIPAILSQLREQRMNLVQTQDQYKFVCGTVM
| .| |..|| .|.|... |..   ...||.||   .||..||.|   .|.
Gtfitldiclsrleevgt.vdvvetvkllrtqrafsiqtpeqyefcylavl
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 1768-1995 1.3e-57 190.1 In-house 43-273 (515) alignment 
Range on Protein: 1768-1995
Range on HMM: 43-273/515.0
NAVRNRYRDILPYDDTRVKL----DSSNNDYINANHLSFESNGTtfSYIASQA------KHFWQMVWEQQVRLICMLTTLVEGGRTKCHQYWPSAPGDTC
|  .|||..||||| .||||    |. ..||.|| ..    |    .|||||.      . ||..|....|  | |.| | || . || .|||  |||. 
nfkknryknilPydsvrvklevindnPhsdyfnasyipsfdndk..ayiasqgPnkasvddfWrlvlqenvttiamvtklkegdkikcgkyWPdkpgdsv

QFGDFSIVLNKEAARKGYILRDITVQRANAkgKRRLFQLQFTAWPDHGLPTSSAEMLTLVKEINNLKSRLVkpMPLLVHCSAGIGRTGVYILLELCLHQL
.|| ... |    |  | | | .|| . .    | . | .|| |||.| |  .  .| |.||.   ....    ||..|||||.|||||.| .. .. . 
kfGsikvelvsleactggikrkltvlkgdd..srtvtqfhfteWPdkGvpkhtssllklikevkadhgqyt..hpliihcsaGvGrtGvvisidsvvaha

QEkAKEVNIPAILSQLREQRMNLVQTQDQYKFVCGTVM
.. .. |..  .. ..|..|. |||||.|| |. |.|.
kt.trmvdvfnfvtnirqkrpylvqtqeqyafiygavl
subfamily_Ptp69D_pd Subfamily Ptp69D 1756-1993 6.6e-57 188.0 In-house 36-281 (307) alignment 
Range on Protein: 1756-1993
Range on HMM: 36-281/307.0
KSRDCSLALKPENAVRNRYRDILPYDDTRVKLDS----SNNDYINANHLsfESNGTTFSYIASQA------KHFWQMVWEQQVRLICMLTTLVEGGRTKC
 ..... . | |||..||| || ..|.|||||       . |||||...  ..   ....||.|.      . ||.|..||.| || ||. | |  | ||
idkstkvsekkenalknRyedikafDktRvkLkkingkedsdYinasfi..kgykekkkfiaaqdPveatigDfWRmiaeqevtlivmlsnlteknrkkc

HQYWPSApgDTCQFGDFSIVLNKEAARKGYILRDITVQRANAKG-----KRRLFQLQFTAWPDHGLPTSSAEMLTLVKEINNLKSRLvkPMPLLVHCSAG
..|||    |..|.||  . | .|   . || |.. | . ....     .|.. | ..|.|.|   | ..  .| |......|..      |..||||||
akYWpie..devqygdilvklvseekhsdyiiReldvskkkeesgevedsrkvvqyhytgWkDskvPevargllklieqvrelykln..rsPivvhCsaG

IGRTGVYILLELCLHQLQEkAKEVNIPAILSQLREQRMNLVQTQDQYKFVCGT
 ||.|... |.. |.||..  ..|.| ..  .||.||  |||  .||.|.   
vgrsgifvaldsllqqlka.edkvdifetvkdLrsqRnllvqsleqYvflyra
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 1763-1995 3.7e-56 185.3 In-house 39-274 (315) alignment 
Range on Protein: 1763-1995
Range on HMM: 39-274/315.0
ALKPENAVRNRYRDILPYDDTRVKL----DSSNNDYINANHLSFESNgtTFSYIASQA------KHFWQMVWEQQVRLICMLTTLVEGGRTKCHQYWPSA
| ...|  .|||..|||.| .||||    || ..||||| ..    .    .|||||.      . ||.||....|  | |.| . || . || ||||  
aretinfkknryknilPldsarvkleviddsPdsdyinasyiksvdd..dkayiasqgPlkasvddfwrmvlqekvttivmvtkkqegdkikcrqywPdr

PGDTCQFGDFSIVLNKEAARKGYILRDItVQRaNAKGKRRLFQLQFTAWPDHGLPTSSAEMLTLVKEINNLksRLVKPMPLLVHCSAGIGRTGVYILLEL
 .|. .|| ... | .  |  . . | . | | ... .|.. | ||| |||.| .  .. .| |.||.     .  |  .||||||||.||||| | .. 
kadsvefGsikvellsleadtdgvarkl.vtr.kseesrtvtqfqftewPdkGvdkqtssllklikevkad..ngkkefsllvhcsaGvGrtGvviside

CLHQLQEKaKEVNIPAILSQLREQRMNLVQTQDQYKFVCGTVM
.. |.... . |..  .. .||..|. ||||...| |. ..|.
vvaqikrt.rsvdvfnfvknlrakrpylvqteeeyafiydavl
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 1759-1999 4.7e-56 185.2 In-house 39-284 (319) alignment 
Range on Protein: 1759-1999
Range on HMM: 39-284/319.0
DCSLALKPENAVRNRYRDILPYDDTRVKLD----SSNNDYINANHLsfESNGTTFSYIASQA------KHFWQMVWEQQVRLICMLTTLVEGGRTKCHQY
. . | |.||  .|||..||.|| |||.|     . . |||||...  ..      .|| ||      . ||.||||...  . ||| ||| .. |...|
tfdsaskeenkkknryqnilaydrtrvvlseldgvegsdyinasfi..dgyqerekfiatqaPlentiedfWrmvWeeessivvmltklveklkvklkky

WPSApgDTCQFGDFSIVLNKEAARKGYILRDITVQRANAKG-KRRLFQLQFTAWPDHGLPTSSAEMLTLVKEINNLKSRLvKPMPLLVHCSAGIGRTGVY
||..  .  ..| . . |..|   ..|| |..........   |.... |.|.||||. |...  .| |.|.|.. ...  .  |. ||||||.|||| .
wpee..nfeeyGrlivtleeeeeledyiirklklnkkssevetRevkhfqyteWpdhdvPekatslldllkrirksrekt.qsgPivvhCsaGvGRtGtf

ILLELCLHQLQEKAkEVNIPAILSQLREQRMNLVQTQDQYKFVCGTVMALSK
| |.  | ...| .  ...  . |.|| ||  .||...||||.  ....  .
ivldamlervkeeg.vlDvfstvsrlRtqRnimvqrpeqYkfiyealleave
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 1768-1995 2e-55 182.8 In-house 28-265 (274) alignment 
Range on Protein: 1768-1995
Range on HMM: 28-265/274.0
NAVRNRYRDILPYDDTRVKLD-----SSNNDYINANHLSFEsNGTTFSYIASQA------KHFWQMVWEQQVRLICMLTTLVEGGRTKCHQYWPSAPGD-
.. .|||..||| . .|| |      ... .|||||..    ....  |.| |       . ||.|.....|..| ||| | |  ..||..|.| | .  
sqtknryktilPnensrvllesessededssyinanyikGy.deeskayvatqGPlpntvadfWrmiyqeevqvivmltklkeaneqkCavyfPdaedye

-TCQFGDFSIVLNKEAARKGYILRDITVQRANAkgKRRLFQLQFTAWPDHGLPTSSAEMLTLVKEINNLKSRLVKP-MPLLVHCSAGIGRTGVYILLELC
 . ..||..|  .|   |..| .| .... ..   .|..    .|.||||  | .  ..| ||.|... ...  ..  | .|||||||||||..|  ...
iserygdveikvekiverndysvrklvlkyler..ersvkhywytdWPdhksPddantlldlvleveesreeenaklapvvvhCsaGiGrtGcfiaisia

LHQLQEKaKEVNIPAILSQLREQRMNLVQTQDQYKFVCGTVM
..||.|. . |..  | ..|| .|  .|||..||...  ...
vrqlree.ivvdvlkivcnlrldrGGmvqtseqyelihralc
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 1768-1994 8.7e-55 180.9 In-house 51-280 (297) alignment 
Range on Protein: 1768-1994
Range on HMM: 51-280/297.0
NAVRNRYRDILPYDDTRVKLDSSNND----YINANHLSFESN--GTTFSYIASQAKHFWQMVWEQQVRLICMLTTLVEGGRtKCHQYWPSAPGDTcqFGD
|  ..||..|||||  |||| . |.|    |.|| ..    .   ||     .  . ||.||...||  | ||. . |. . || .||.     |  |||
nfeksRYkniLPydssRvkLaivnddpdsDyvnasfvkgnkhrlittqmPmkatvadfWamvldeqvstivmlnddnerdk.kcaryWsdkgvtt..fGd

FSIVLNKEAARKGYILRDITVQRANAKGKRRLFQLQFTAWPDHGLPT--SSAEMLTLVKEINNLKSRLVKPmPLLVHCSAGIGRTGVYILLELCLHQLQE
 |.||.  . |.|.| |...|.. .|| .| . | ||. |||.  .   | . .| |..|...  |   .  ||||||.||.|||||.. .. .. . ..
vsvvllsvsereGfikrelevtkgkakarrvvkqyqfveWPdkaverkdsassllklisevrkdfsqnaeg.PllvhclaGvGrtgvlltidsvvaeakr

kAKEVNIPAILSQLREQRMNLVQTQDQYKFVCGTV
  |||.|  ....||..|..||||..|||||  .|
.ekevdifglvkklrqerpylvqtkeqykfvyvav
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 1759-1996 5.6e-54 178.0 In-house 37-281 (290) alignment 
Range on Protein: 1759-1996
Range on HMM: 37-281/290.0
DCSLALKPENAVRNRYRDILPYDDTRVKLD--SSNND----YINANHLSFESNGTTF----SYIASQAKHFWQMVWEQQVRLICMLTTLVEGGRTKCHQY
    .| ..|  .||...|..||| |. |   |...|    |||| ..   ..   .    . . . ...||...|...|  | |||. .| |..||.||
tvtvgltssnkllnRfanivvyddnritLrpisghkDCtneyinAcyikgykekkqyiatqgpvsntlvdFWkliwqekvtiivmltniieegkvkCqqY

WPSApgDTCQFGDFSIVLNKEAARKGYILRDITVQRANA-KGKRRLFQLQFTAWPDHGLPTSSAEMLTLVKEINNLKSRLVkPMPLLVHCSAGIGRTGVY
||..  || ..| ||| |..| . ..|| | . |.  |. . |. . |.|.|.|...|  |  . .|....|... . .     ...||||...||..|.
Wpds..dtkaygefsikllneetlneyierklevknknsagakqsvtqyqitnwdstgkvtnpqtillvieemyktqrkrg.ntsivvHCSdtvgrsavf

ILLELCLHQLQeKAKEVNIPAILSQLREQRMNLVQTQDQYKFVCGTVMA
. ..  . . . .   ... ..| ..| |....|||..||....  |. 
caaattinkck.tegvidvfqvlksqRiqkpgsvqtvqqyqgifqivlt
subfamily_PTPRG_pd Subfamily PTPRG 1756-1995 7.4e-54 177.9 In-house 35-284 (563) alignment 
Range on Protein: 1756-1995
Range on HMM: 35-284/563.0
KSRDCSLALKPENAVRNRYRDILPYDDTRVKLDSS-----NNDYINANHLSFESNGTTfsYIASQ------AKHFWQMVWEQQVRLICMLTTLVEGGRTK
|. |.. . ||||  .||| .|..|| .|||| .      . ||||||..     .    .||.|      .. ||.|.|||.| .| |.| ||| || |
kdldaehsqkpenkrKnRylnivaydrsRvklsplpgkkkklDYinAnyidGyqkska..fiatqgplkdtfddFWrmiWeqnvaiivmitnlvergrrk

CHQYWPSapGDTCQFGDFSIVLNKEAARKGYILRDITVQRANAK------GKRRLFQLQFTAWPDHGLPTSSAEMLTLVKEINNLKSRLVKpmPLLVHCS
|..|||.   .. ..| ... | .|     |  | ....  . |       ...  | ..| ||||| |..|.  |. ||  .  . . .   |..||||
cdvYWPk..desetygalqvtlieeevlalytvrtlviknlklkkkkqcdteklvrqyhytkWPdhgvPehslpvLifvkkssaankaeaG..PivvHcs

AGIGRTGVYILLELCLHQLQEKaKEVNIPAILSQLREQRMNLVQTQDQYKFVCGTVM
||.||||.|| |.  |.|.|.. . ||.  .| ..| || .||||..|| |.  ...
aGvgrtGtyivldtllkqiqqe.navnvfgflkhiraqRnflvqteEqYiflhdall
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 1767-1995 2.6e-53 175.7 In-house 2-236 (237) alignment 
Range on Protein: 1767-1995
Range on HMM: 2-236/237.0
ENAVRNRYRDILPYDDTRVKLD--SSNNDYINANHLSfESNGTTFSYIASQA------KHFWQMVWEQQVRLICMLTTLVEGGRTKCHQYWPSAPgDTCQ
|| ..||| .|  || .|| |    |. |||||..|  . .||  .|||.|       . ||||||...  .| ||| |.|| . |||.||||.  .   
enkiknrygnivaydhsrvvlkgagsgsdyinatylk.gfdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywpstd.qpaa

FGDFSIVLNKEAARKGYILRDITV-QRANAKGKRRLFQLQFTAWPDHGLPTSSAEMLTLVKEINNLKSRLVKPMPLLVHCSAGIGRTGVYILLELCLHQL
.| ... | |. .   | .| ... .| . |. | ..| |||.|||.|.|  .| .| . |.| |    . .  | ..|||||.||||......  |.| 
ygvltvslkkkeefsdytvrslllskrltlkevrlihqyqftswpdrgvpqqtaallrfrkniinrsphvsesgpwiihcsagvgrtgiflvidamlrqa

QEKaKEVNIPAILSQLREQRMNLVQTQDQYKFVCGTVM
.|| | |.|   .  . |.|  ..||.||| |.  |..
kek.kvvdiynyvysieedrpyiiqtkdqyvfihqtil
subfamily_PTPRA_pd Subfamily PTPRA 1759-1994 3.7e-53 175.5 In-house 49-291 (330) alignment 
Range on Protein: 1759-1994
Range on HMM: 49-291/330.0
DCSLALKPENAVRNRYRDILPYDDTRVKLDS----SNNDYINANHLSFESNgtTFSYIASQA------KHFWQMVWEQQVRLICMLTTLVEGGRTKCHQY
 . || | ||  .||. .||||| .|| |       . ||||| ..    .    ..||.|       . ||.|.|||.   | ||| | |  ..||.||
tlelaskeenkeknrvvnilPydfsrvilsvkeGveesdyinasfidGyke..kdkfiaaqGPkeetvedfwrmiweqksativmltelkerkeekcaqy

WPSApgDTCQFGDFSIVLNKEAARKGYILRDITVQ----RANAKGKRRLFQLQFTAWPDHGLPTSSAEMLTLVKEINNLKSRLVKpmPLLVHCSAGIGRT
||.    .  .|.  . ...|   . | .|.. ||     .. | .| . |. ||.||| |.|. .  || |.|....|. .     |. ||||||.|||
wPde..GlvtyGnirvevedetvlvdytvrkflvqqlpdatrekksrlvrqfhftswPdvGvPfepiGmlkllkkvkklnqqsag..pivvhcsaGvGrt

GVYILLELCLHQLQEKaKEVNIPAILSQLREQRMNLVQTQDQYKFVCGTV
| .| |.  |.... . . |..  ....|| || ..|||. ||.|.  ..
Gtfivldavlervkae.rkvdvfefvkrlrlqrpqmvqtdeqyefiykvl
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 1761-1996 2.3e-52 172.8 In-house 40-276 (287) alignment 
Range on Protein: 1761-1996
Range on HMM: 40-276/287.0
SLALKPENAVRNRYRDILPYDDTRVKLDSSNNDYINANHLSFESNGTTF----SYIASQAKHFWQMVWEQQVRLICMLTTLVEGGRTKCHQYWPSAPGdt
  .. ..|  .||...||..|. || |   ..||||| ..   ..   |    | ... |. ||.......|  | ||. . |  . .|.||||.     
thniasqnkdknRltqilvpdnyrvllkgehpdyinavfidgykekkafiiaesPmfntarnfWkliddrnvtaivmlcqekendeevcyqyWpeeks..

CQFGDFSIVLNKEAARKGYILRDITVQRAN-AKGKRRLFQLQFTAWPDHG-LPTSSAEMLTlVKEINNLKSRLVKpMPLLVHCSAGIGRTGVYILLELCL
  .|...| | .|   .||| |.. |.. | |. |... | |.|.|...| ...  . .|  ..| .  . .  .  ...||||...||.....  .  .
vvlGeyniellneevnagyierklevknknkagdkqqvkqyqitnWdstgkvtepqtillv.ieemyktqrkrgn.tsivvhCsdtvGrsamfcaaatti

HQLQeKAKEVNIPAILSQLREQRMNLVQTQDQYKFVCGTVMA
.. . .   ...  .| . | |... ||| .||||..  |..
nkck.teGviDvfqvlksqriqkpgsvqtveqykfindivle
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 1762-1994 9.9e-52 170.6 In-house 3-238 (250) alignment 
Range on Protein: 1762-1994
Range on HMM: 3-238/250.0
LALKPENAVRNRYRDILPYDDTRVKLDSSN----NDYINANHLSFESNGttFSYIASQA------KHFWQMVWEQQVRLICMLTTLVEGGRTkCHQYWPS
.| ||.|  .||| ||...| .|| | ...     ||||| .|   ..    ..||.|.      ..||.||.|...  | |||.|.| ..| .||||| 
vakkpqnkeknryadiialdssrvvLekekgdkesdyinasflhgyder..kafiatqgPlqatiedfWrmvleeksgtivmLtnLkesekt.yhqywPv

ApgDTCQFGDFSIVLNKEAARKGYILRDITVQRANAKGKRRLFQLQFTAWPDHGLPTSSAEMLTLVKEINNLKSRlVKPMPLLVHCSAGIGRTGVYILLE
    . ..||  . | ..     |. | . . .|. ...| . ||.|..||| | |     .| |.|...  . . ..  |..|.||||.||.| .| ..
e..kaekyGdvtvsllskeefadytkrklklskakkaderivrqlhfvvWPdkgvPevatavLellkkvqasqqq.agnaPvivqCsaGvgrsGafiaid

LCLHQLQeKAKEVNIPAILSQLREQRMNLVQTQDQYKFVCGTV
  |..|. | | |..  .. .||..|.. |....|| ||   .
avlerlk.kekvvdvfkvikvlrkdrphavesleqyvfvyeii
subfamily_PTPRK_pd Subfamily PTPRK 1763-1995 2.2e-51 169.5 In-house 38-274 (314) alignment 
Range on Protein: 1763-1995
Range on HMM: 38-274/314.0
ALKPENAVRNRYRDILPYDDTRVKLDSS----NNDYINANHLsfESNGTTFSYIASQ------AKHFWQMVWEQQVRLICMLTTLVEGGRTKCHQYWPSa
| | ||  .||. |||.|| .||.| .     ..|||||. .  .|   .  .|. |       | ||..|....   | ||| ||| || || .|||  
akkdenreknrsgdilaydrsrvflitidgdpssdyinaali..dsykrpaafivtqgPlqetvkdfWrlvydencasivmltelvevgrvkClkyWPe.

pgDTCQFGDFSIVLNKEAARKGYILRDITVQR--ANAKGKRRLFQLQFTAWPDHGLPTSSAEMLTLVKEINNLKSRlvKPMPLLVHCSAGIGRTGVYILL
  || ..||. . | .  . . .. |  .|..   . ...| . |.||..||||. |.|   .|.||..... .    .  ...|||||| ||||..| .
..dtevygdikvelvetellaelvvrifrveklargqeeirevrqfqflgWpdhdvPvsatgllklvrrvkksqee..eaGrivvhCsaGaGrtGtfiai

ELCLHqLQEKAKEVNIPAILSQLREQRMNLVQTQDQYKFVCGTVM
.  |  . |. . |..  .  .||....|.|.|..||||.   ..
divld.mieregvvdvfnavktlrsrkvnmveteeqykfiydvil
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 1759-1994 3.2e-51 169.5 In-house 52-287 (319) alignment 
Range on Protein: 1759-1994
Range on HMM: 52-287/319.0
DCSLALKPENAVRNRYRDILPYDDTRVKLDSS----NNDYINANHLSFESngTTFSYIASQA------KHFWQMVWEQQVRLICMLTtlveggRTKCHQY
| . |  ..|  .||. .||..| ..|||.        ||||| ...         |||.|       . ||.|.||...  | .||      . || ||
dqtfanldqnkdknriinilafdknvvklerliGeefsdyinasfvtGyq..rkdkyiaaqGPldntladfWrmiweyncstivllt......kdkcsqy

WPSAPGDTCQFGDFSIVLNKEAARkgYILRDITVQR-ANAKGKRRLFQLQFTAWPDHGLPTSSAEMLTLVKEINNLKSRLVKPMPLLVHCSAGIGRTGVY
||     . . .. .. . .|.|   |..||| . . .. |..|.. |  |  |||.| | .......||| .. |.|.  .. ...||||||.||||||
wplkivikeerfkvkvdsveetae..yvvrdielsedgkekdirkitqfhflGwpdvGvpdypsdlmrlvkkvrhltskenhranivvhcsaGvGrtGvy

ILLELCLHQLQEkAKEVNIPAILSQLREQRMNLVQTQDQYKFVCGTV
| |.  |....|  | |..  .. .||.|| .|||   ||||.  ..
ivldvlldrmke.ekqvdvynfvrdlrqqrntlvqdlvqykfiysal
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 1759-1994 1.2e-50 167.6 In-house 16-251 (284) alignment 
Range on Protein: 1759-1994
Range on HMM: 16-251/284.0
DCSLALKPENAVRNRYRDILPYDDTRVKLDSS----NNDYINANHLSFESngTTFSYIASQA------KHFWQMVWEQQVRLICMLTtlveggRTKCHQY
| . |  ..|  .||. .||..| ..|||.        ||||| ...         |||.|       . ||.|.||...  | .||      . || ||
dqtfanldqnkdknrighilafdknvvklerliGeefsdyinasfitGyq..rkdkyiatqGPldntladfWrmiweyncstivllt......kdkcsqy

WPSAPGDTCQFGDFSIVLNKEAARkgYILRDITVQR-ANAKGKRRLFQLQFTAWPDHGLPTSSAEMLTLVKEINNLKSRLVKPMPLLVHCSAGIGRTGVY
||     . . .. .. . .|..   |..||| . . .. |..|.. |  |  |||.| | .......||| .. |.|.  .. ...||||||.||||||
wplkivikeerfkvkvdsveesee..yvvrdielsedgkekdirkirqfhflgwpdvgvpdypsdlmrlvkkvrhltskenhranivvhcsagvgrtgvy

ILLELCLHQLQEkAKEVNIPAILSQLREQRMNLVQTQDQYKFVCGTV
| |.  |....|  | |..  .. .||.|| .|||   ||||.  ..
ivldvlldrmke.ekqvdvynfvrdlrqqrntlvqdlvqykfiysal
subfamily_PTPRN_pd Subfamily PTPRN 1759-1995 1.4e-49 163.4 In-house 47-289 (297) alignment 
Range on Protein: 1759-1995
Range on HMM: 47-289/297.0
DCSLALKPENAVRNRYRDILPYDDTRVKLDSS----NNDYINANHLsFESNGTTFSYIASQA------KHFWQMVWEQQVRLICMLTTLVEGGRTKCHQY
 ...| ...|. .||....||||..||||...    ..|||||  . ....  . .|||.|.       .|||||||| | .| .||.| | | ..|..|
tkevakaeknvkknrskavlpydhsrvklkeeasaeksdyinasai.ldhdprapayiatqgplastvadfwqmvweqGvvvivnltrleeegvkqckry

WPSAPGDTCQFGDFSIVLNkEAARKGYILRDITVQRANAKGKRRLFQLQFTAWPDHGLPTSSAEMLTLVKEINnlKSRLVKPMPLLVHCSAGIGRTGVYI
||    .. .. .  .| .     . |..| . ..  ...  | . |. | .||..| |.|.  .| . . .|  ||   .  |..||||.| |||||||
wpdeGsevyhiyevhlvse.hiwcddylvrsfylknlqtsetrtvtqfhflswpeegvPasaksllefrrkvn..ksyrGrscpivvhcsdGaGrtGvyi

LLELCLHQLQEKAKEVNIPAILSQLREQRMNLVQTQDQYKFVCGTVM
|..| |..|.  .||..| | |  ||.|| .||.|.||..|. ..| 
lidlvlnrllkGvkeidiaatlehlrdqrpglvktkdqfefaltava
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 1759-1995 1.1e-48 160.6 In-house 24-292 (297) alignment 
Range on Protein: 1759-1995
Range on HMM: 24-292/297.0
DCSLALKPENAVRNRYRDILPYDDTRVKLDS--SNNDYINANHLSFESNGTTFSYIASQA------KHFWQMVWEQQVRLICMLTTLVEGGRTKCHQYWP
. | | ..    .||||||| .|||||||    ...|||||... |  . . . || .|       . ||..|.||.|| | |.. | |.|| ||  |||
sfssakrnsslrknryrdilatddtrvkllrviterdyinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmvaklqedGrdkcapywp

SAPGDTCQFGDFSIVLNKEAARKgYILRDITVQR-ANAKGKRRLFQLQFTAWPDHGLPT-----------------SSAEMLTLVK--------EINNLK
|. ..  . ||. .    . . . .    .|  .    . .| .   || .|||||.|.                 .   ||.||.        ... |.
svvqerlkagdvvveflsstsde.fdrviltelqliyrsesrvvrhvqflswpdhGvpsdledlvrfqaqvcscciavpmmlalvemftamvflqleslr

SRLVKPMPLLVHCSAGIGRTGVYILLELCLHQLQeKAKEVNIPAILSQLREQRMNLVQTQDQYKFVCGTVM
.   ....||||||||.||.|| .| .  | .|. | .  .. ||||.|||||  |||| .|....   |.
aemprnayllvhcsaGvGrsGvvvlsdvilaklr.kkripdvaailsilreqrarlvqtleqfellydavl
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 1751-1994 3.8e-48 158.8 In-house 16-262 (283) alignment 
Range on Protein: 1751-1994
Range on HMM: 16-262/283.0
RRGLVKSRDCSLALKPENAVRNRYRDILPYDDTRVKLDSSNNDYINANHLS-FESNGTTFSYIASQA------KHFWQMVWEQQVRLICMLTTLVEGGRT
.|  | ..|. .|   ||   ||...|.|.|  ||.|.| ..||||| ..   .|.     ||..|.      . ||.||.....  | ||| | |. | 
krlsvpdldadiasadenkrknrnqeivpadqwrvelksesrdyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfdekitaivmltklqedlri

KCHQYWPSApgDTCQFGDFSIVLNKEAARKGYILRDITVQRA-NAKGKRRLFQLQFTAWPDHGlptSSAEMLTLVKeINNLKS--RLVKPMPLLVHCSAG
|| ||||.    . ..|.| . |.|| . . .| . ....    || .  |   |.  | . |     | . .||| .| ..|  .  |  |..||||.|
kCsqyWPkr..GsedyGeftvtlrkettsnsfiikelllrvnssakstlllahyqvidWleyg...eqaiinslvk.fnkvislqteskkgPivvhCstg

IGRTGVYILLELCLHQLQEKAkEVNIPAILSQLREQRMNLVQTQDQYKFVCGTV
||||.|.| .   ..... ..  |...|..  .||||| .|||.||||.|   |
iGrtavfiaasasvkdaltes.vvdvfavvkimreqrmmavqtldqyklvhelv
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 1762-1993 2e-44 146.8 In-house 43-274 (315) alignment 
Range on Protein: 1762-1993
Range on HMM: 43-274/315.0
LALKPENAVRNRYRDILPYDDTRVKL----DSSNNDYINANHLSFESngTTFSYIASQA------KHFWQMVWEQQVRLICMLTTLVEGGRTKCHQYWPS
 | | ||  .||| .|..|| .||.|      .. ||.||| .   .      |||.|.      | ||..|.|...  | ||| |||| . |. .||| 
vakkienkqknryiniiaydksrvqlpllendphsdyvnanfidGyn..kkrryiaaqgpnvasvkdfwrlvfeedigkivmltnlvegekrkaekywpd

ApgdTCQFGDFSIVLNKEAARKGYILRDITVQRanAKGKRRLFQLQFTAWPDHGLPTSSAEMLTLVKEINNLKSRLVkpMPLLVHCSAGIGRTGVYILLE
       .| ... . .|   . |  | ..|     .  | ..||..|.||| |.| ..  .. |.. ..  .   |   ...||||||.|||| .| |.
k...kviyGkitvtrkseevnteytvrtlsvvf..gdnirevvqlhytswpdmgvpkytiplmnlirtvkqhhtnsv..gaivvhcsaGvGrtGtfitld

LCLHQLqEKAKEVNIPAILSQLREQRMNLVQTQDQYKFVCGT
  |.|. |  . ...  .. ..|..|...||. .||.|.  .
avldqa.eaenaidvynfitgvrqnrikmvqvaeqyqfiyda
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 1765-1994 2e-44 146.5 In-house 4-236 (239) alignment 
Range on Protein: 1765-1994
Range on HMM: 4-236/239.0
KPENAVRNRYRDILPYDDTRVKLDSSN----NDYINANHLSfESNGTTFSYIASQ------AKHFWQMVWEQQVRLICMLTTLVEGGRTKCHQYWPSApg
|  |  .||| .|. || .|| |.  .    .|||||..|  . .|.  .|||.|      .  ||.|.|...  .| ||| |.|| . ||||||| .  
krvnkaknryanivtydhsrvvleklsndphsdyinasylr.dydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpds..

dTCQFGDFSIVLNKEAARKGYILRDITVQRANAKGKRRLFQLQFTAWPDHGLPTSSAEMLTLVKEINnlKSRLVKPMPLLVHCSAGIGRTGVYILLELCL
 | .. .. . | |      ||.| . . .     .| ..| .|| |||.|.|  .. .| | ..|   |  |    | ..|||||.|||| .....  |
.tskycnlrvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrkit..kdslpgarpwvihcsagvgrtgaflvidaml

HQLqEKAKEVNIPAILSQLREQRMNLVQTQDQYKFVCGTV
.|  .| | |.|   .  .||.|  .||| .|| |.  .|
rqa.kkqktvdifnyvkairedrphmvqtseqyvfihlav
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 1765-1994 2.1e-44 146.5 In-house 5-237 (239) alignment 
Range on Protein: 1765-1994
Range on HMM: 5-237/239.0
KPENAVRNRYRDILPYDDTRVKLDSSN----NDYINANHLSfESNGTTFSYIASQ------AKHFWQMVWEQQVRLICMLTTLVEGGRTKCHQYWPSApg
|  |  .||| .|. || .|| |.  .    .|||||..|  . .|.  .|||.|      .  ||.|.|...  .| ||| |.|| . ||||||| .  
krvnkaknryanivtydhsrvvleklsndphsdyinasylr.dydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpds..

dTCQFGDFSIVLNKEAARKGYILRDITVQRANAKGKRRLFQLQFTAWPDHGLPTSSAEMLTLVKEINnlKSRLVKPMPLLVHCSAGIGRTGVYILLELCL
 | .. .. . | |      ||.| . . .     .| ..| .|| |||.|.|  .. .| | ..|   |  |    | ..|||||.|||| .....  |
.tskycnlrvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrkit..kdslpgarpwvihcsagvgrtgaflvidaml

HQLqEKAKEVNIPAILSQLREQRMNLVQTQDQYKFVCGTV
.|  .| | |.|   .  .||.|  .||| .|| |.  .|
rqa.kkqktvdifnyvkairedrphmvqtseqyvfihlav
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 1767-1998 6e-43 141.7 In-house 37-277 (287) alignment 
Range on Protein: 1767-1998
Range on HMM: 37-277/287.0
ENAVRNRYRDILPYDDTRVKLDSS---NNDYINANHLSFESNGTT----FSYIASQAKHFWQMVWEQQVRLICMLTTLVEGGRTKCHQYWPSApGDTCQF
 .. .||| |.||.||||| |        ||||||...   .  .     . ||.  . ||..|.|...  . ..|  || .| ||..|||       . 
aavkknryadvlPiddtrvllsaegelGsdyinanyvasytddeafiaaqgPiaatvrdfwravletrsasvitmtreveearlkcykywPer.evPmrv

GDFSIV-LNKEAARKGYILRDITVQRANAKGKRRLFQLQFTAWPDHGLPTSSAEMLTLVKEI---NNLKSRLVKPMPLLVHCSAGIGRTGVYILLELCLH
| .|.| |...     |  | . .  ....  | . ||.. .|||..|. ..  .. .| ..    .|.    .  ||.||...||||.|... .  ...
GGysvvlldydikePeygvralrlidletrearvvkqldllswPdkvlaPtavglirfvldvkqhielardasevGPlvvhddvGiGrsGillatlvlvs

QlQEKAKEVNIPAILSQLREQRMNLVQTQDQYKFVCGTVMALS
.  |.  .|.. |.. .|||.|  |||.  |..... ....  
r.ledlGrvdvaavvirlreyraalvqavvqlrllyealvtyy
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 1761-1992 1.4e-40 134.4 In-house 41-282 (325) alignment 
Range on Protein: 1761-1992
Range on HMM: 41-282/325.0
SLALKPENAVRNRYRDILPYDDTRVKL----DSSNNDYINANHLSFESNGTTFsyIASQA------KHFWQMVWEQQVRLICMlTTLVEGGRTKCHQYWP
  | ||||  .||.......| .|| |    |... |||||..|  . .  .|  .|.||      . .|..| . .  .. . .  ...|  .| .|||
kvamkpenkaknrfknvvaldksrvvletkkddpssdyinasylrddkkkdvf..laaqaPltatindlWrlvldWrcsvvvv.lneldlgkdrcavywp

SAPGDTCQFGDFSIVLNKEAARKGYILRDITVQRANAKGKRRLFQLQFTAWPDHGLPTSSAEMLTLVKEINNLKSRLVK----PMPLLVHCSAGIGRTGV
   |.. .|| . . |        |. | . |....    | . |.|. .|.| | .   | ...... ..... |.        |.|||||||.|||||
kemgksktfGglevklrtieeisdyvhrvldvkqvkkGetrsvkqfqlqswddmGvqkrpatlisilqlvkavservtantkastpilvhcsaGvGrtGv

YILLELCLHQLQEKAkEVNIPAILSQLREQRMNLVQTQDQYKFVCG
.| |   | .. |.. .|.|   . .||..| ..|.| ||| ..  
fislysalakviees.rvdifgfvkklrkdrpsmvetvdqyiliye
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 1769-1998 1.6e-40 133.6 In-house 57-283 (290) alignment 
Range on Protein: 1769-1998
Range on HMM: 57-283/290.0
AVRNRYRDILPYDDTRVKL-DSSNNDYINANHLSFESNG--TTFSYIASQAKHFWQMVWEQQVRLICMLTTLVEGGRTKCHQYWPSAPGDTCQFGDFSIV
  .|||.|.   | ||| | |  . ||. ||..         |   ... .  .|.|| ...|  |.||  |.| |..||.||.|   |..  ||.....
fkknrykdvvcndktrvilkdGydGdyvhanyvkGlkamfiltqGalkdtvidiwrmvlqekvaaivmlceliedGkakceqyypekeGevltfGeitvl

LNKEAARKGYI-LRDITVQRANAKGKRRLFQLQFTAWPDHGLPTSSAEMLTLVKEINNlksrlvKPMPLLVHCSAGIGRTGVYILLELCLHQLQeKAKEV
  .|  .   | .. ..|.  ..  . .|  |.  .|||. .. |.  .| ... . .       . |. ||||||||||| .. .| .|  |  . ||.
cseeddkdaniikktlsvrdkdsGkehklkhlkikswpdksvalstlallrtlrilrk......asGpvvvhcsaGiGrtGtfvaievglqill.dGkel

NIPAILSQLREQRMNLVQTQDQYKFVCGTVMALS
..  .   ||. |.| || . ||  .   .. | 
dlldlvralrnsrlnsvqvdiqylalveilldlG
0041856 (Phosphotyrosine protein) phosphatases II 1768-1991 1.4e-39 131.0 In-house 1-164 (182) alignment 
Range on Protein: 1768-1991
Range on HMM: 1-164/182.0
NAVRNRYRDILPYDDTRvkldssNNDYINANHLSFESNGTTfsYIASQA------KHFWQMVWEQQVRLICMLTtlveggrtkCHQYWPSAPgdtcqfgd
|  .|||.|||||| .|      ..|||||| . .   .|.  .|| |.       .|..|..|.....| .||         ...|||.          
nldknrysdilpydhsr......dldyInanlylgslpatr..fiatqgpllstvadflrmlkelgittivnlt.........eelywpell........

fsivlnkeaarkgyilrditvqranakgKRRLFQLQFTAWPDHGLPTsSAEMLTLVKEINNlksrlvKPMPLLVHCSAGIGRTGVYILLELCLHQlqeka
                            .|  .|.... ||||| |.   |.| ...|...      .. | |||||||.||||..... |....     
............................erlgiqylylpwpDhgvpd.ldelldfieevle......eggpvlVHCsaGvgRtgtlvaaylmkkl.....

kEVNIPAILSQLREQRMNLVQTQDQYKFVC
 .|... .....|..|.. |.| .|| |. 
.gvsleeavklvrsrRpgmvitpnqyfflq
0051429 (Phosphotyrosine protein) phosphatases II 1792-1996 2.1e-39 131.1 In-house 4-223 (272) alignment 
Range on Protein: 1792-1996
Range on HMM: 4-223/272.0
NDYINANHLSFEsngttFS------YIASQA------KHFWQMvWEQQVRLICMLTTLVEGGRTKCHQYWP----------SAPGDTCQFGDFSIVLNKE
..||||....       ..      ...|..      ..||.. .|.... |..|....| || ||..|||          .    |  .|.... | .|
sgyiNardvggy.....grvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllse

AARKGYILRDITVQRA-NAKGKRRLFQLQFTAWPDHGLPTSSaeMLTLVKEINNlksrlvkPMPLLVHCSAGIGRTGVYILLELCLhQLQEKAKEVN---
     |||| ... .  .|.  |....|..|.||||| |...  .|.|......       . |.|||||||..|||....| |.| .  ..   |.   
ellldyilrellltlllsagearevmhlhytdwpdhgvpqea..llellellld.......ggpvlvHCsaGkdRTGtvvalllll.lgvsletivddYl

-----IPAILSQLREQRMNLVQTQDQYKFVCGTVMA
     . .....||.||.. |||..||.|..  ...
ltnlyleeaveelraqrpgavqteeqylflyealle
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 1758-1995 8.6e-39 128.2 In-house 38-276 (439) alignment 
Range on Protein: 1758-1995
Range on HMM: 38-276/439.0
RDCSLALKPENAVRNRYRDILPYDDTRVKL----DSSNNDYINANHLSFESNgtTFSYIASQ------AKHFWQMVWEQQVRLICMLTTLVEGGRtkchq
 ..||| .  .  .|||.|. ..| ||| |          |||||..    .     |||.|      ...||..|.|...  | ||| |||  .     
ciaslaaqeydqtknrykdvgafdhtrvtlqeipgvphshyinanyikGyyd..dklyiatqgpkkettddfwrlviekktvtivmltnlvesyk.....

YWPSApgDTCQFGDFSIVLNKEAARKGYILRDITV--QRANAKGKRRLFQLQFTAWPDHGLPTSSAEMLTLVKEINNLKSRlVKPMPLLVHCSAGIGRTG
||||   . . .|| ..  ...     |..| . |  .| ... .| ..|....||||. .|. .. .| ... ||  . .  .  |..||||||.||||
ywpsd..aevcygdiavrvdrnielpnyvirgfkvfnerdttekertvlqfhyiawpdknvpaqashvldflrainsandk.eeygpvvvhcsagvGrtG

VYILLELCLHQLQEKAKeVNIPAILSQLREQRMNLVQTQDQYKFVCGTVM
  | |...| ||. . | |.|  |.. ||.|| ..||.  || |.  .|.
tiialdialeqlklenk.vdikgivkvlrkqrkqmvqalcqyvfiynavl
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 1756-1991 9.1e-39 127.9 In-house 28-286 (301) alignment 
Range on Protein: 1756-1991
Range on HMM: 28-286/301.0
KSRDCSLALKPENAVRNRYRDILPYDDTRVKLDS------SNNDYINANHLSFESNGTTFSYIAS----QAKHFWQMVWEQQVRLICMLTTLVEGGRTKC
... |.. |. ||.. ||...| .||| |. |        ....||||....  |. . |    .      . ||...|....  | |.| | || ..||
edksctvglseenkalnrfknitvyddnriilkpkpnldlcqreyinasyidgysekkkfiaaqgpmkktlvdfWrliwqekpvsivmvtnlkegtkskc

HQYWPSAPGDTCQFGDFSIVLNKEAARKGYILRDITVQRANAKG---------------KRRLFQLQFTAWPDHGLPTSSAEMLTLVKEINNLKSRlVKP
.||||..  .. .|| |.. |..|..   ...|...|.  .. .                . . ||| | ||..|.    . .|  . ..   . . .  
eqywpnseaeseefgpftvtlvneqvyPdfvirqlnvkiqdgsnngyierkfkvksdksswdvlqlqvtdWpqdGvvreprtvLqviddvihrqqk.igg

MPLLVHCSAGIGRTGVYILLELCLHQLQEKaKEVNIPAILSQLREQRMNLVQTQDQYKFVC
 |..||||....|.|||. ... | | .     |..  .   .| ...  |.| .|| .. 
gpvvVHCSdtVsrsGvYcsvsiglEQckae.gVVdvfqvtkavrrskpgaVtTLeqytsiy
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 1762-1995 6.7e-38 125.1 In-house 39-233 (392) alignment 
Range on Protein: 1762-1995
Range on HMM: 39-233/392.0
LALKPENAVRNRYRDILPYDDTRVKL----DSSNNDYINANHL-SFESNGttfSYIASQA------KHFWQMVWEQQVRLICMLTTLVEGGrtkchqywp
 | |. |  .|||..||||| .||||    |....||.|| .. ||...    .|||||.      . ||.||....|  |.|.| | ||          
vaqkeinlkknryknilpydsarvkleviddipdsdylnasyipsfdnek...ayiasqgpnaaslddfwrmvfqenvttiamvtklkegd.........

sapgdtcqfgdfsivlnkeaarkgyilrditvqraNAKGKRRLFQLQFTAWPDHGLPTSSAEMLTLVKEINNLKSRLVKpmPLLVHCSAGIGRTGVYILL
                                   . . .|   | .|| |||...|  .. .| ..||..    .  .  ||..|||||.||||| | .
...................................kgddartvaqfhftewPdkdvpkhtssllkfikevkadfGqyth..pliihcsagvgrtgvvisi

ELCLHQlQEKAKEVNIPAILSQLREQRMNLVQTQDQYKFVCGTVM
.  . .  .|.. |..  .....|..|  .|||..|| |. |.|.
dsvvah.akktrmvdvfnfvtnirrkrpymvqtkeqyafiygavl
0036282 (Phosphotyrosine protein) phosphatases II 1792-1991 8.2e-38 125.2 In-house 2-163 (174) alignment 
Range on Protein: 1792-1991
Range on HMM: 2-163/174.0
NDYINANHLSFESNGTTFSYIASQAKhFWQMVWEQQVRLICMLTTLVEGGRTKCHQYWPSapgdtcqfgdfsivlnkeaarkgyilrditvqrANAKGKR
.|||||..|..    . .   .  .. ||.|..|.... . ||....| |..||..|||.                                      .|
sdyinaspldlsyitprliagqgpla.fwemlkelgittvvmlleekelglykcinywpe.................................lredler

RLFQLQFTAWPDHGLPTSSAeMLTLVKEINNLKSRlVKPMPLLVHCSAGIGRTGVYILLELCLHQLQekAKEVNIPAILSQLREQRMNLVQTQDQYKFVC
  .|.... ||||| |..|  .|..||....  |.  .  |.|||||||.||||. ... |.|..|    . |.. ... .|| ||.. |||..||.|. 
lgiqylylpwpDhgvpdlsi.llefvkfveealse.dpggpvlVHCsaGvgRtGtlvaaylmlrgll..eslvdaldlvrelRlqrpgmvqtpsQyrfly
subfamily_CG7180_pd Subfamily CG7180 1755-1994 1.1e-37 124.2 In-house 29-286 (296) alignment 
Range on Protein: 1755-1994
Range on HMM: 29-286/296.0
VKSRDCSLALKPENAVRNRYRDILPYDDTRVKLDS----SNNDYINANHLsfESNGTTFSYIASQA------KHFWQMVWEQQVRLICMLTTLVEGGRtK
... ||  .|. ||  .||. ...||| .|| |..    ...||||| .   .|      ||  .|      . ||..|.....  . .||   .  . .
leigdCagglrkenreknrdvkvvPyDynRvvLekldGeeksdYinavyv..dsflkkkeyivteapkketvdefWrlvydeeisavvvLtktfdfak.m

CHQYWPSAPgdTCQFGDFSIVLNKEAARKGYILRDITVQRA---------NAKG-KRRLFQLQFTAWPD-HGLPTSSAEMLTLVKEINNLKSRL---VKP
...|||       |.|.. . . .|        | . ...          . |  .| . ..|.| |.  . .| |.. .. |.. .. .. .     . 
ypsywpnks..keqygeifveiveekqyanlkirtfkltkkivalteqekqvkaetRivklfqlteWeledkvPlstnalielrrrvrlwrekvdedpee

MPLLVHCSAGIGRTGVYILLELCLHQLQeKAKEVNIPAILSQLREQRMNLVQTQDQYKFVCGTV
 |..|..| | .|.|||. .. .| ... | .||..   . .||..| .||.. ..||..  ..
gPvvvvssdGasRsGvylaidanlelve.keeevdvFeavktlrrsRpqLvenveeYkyiYdvl
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 1767-1996 8.9e-36 118.2 In-house 47-285 (305) alignment 
Range on Protein: 1767-1996
Range on HMM: 47-285/305.0
ENAVRNRYRDILPYDDTRVKLDSS-NNDYINANHLSFESNGTTFSY----IASQAKHFWQMVWEQQVRLICMLTTLVEGGRTKCHQYWPSAPGDTCQFG-
..| .|||.|.   |. ||||...   .|| ||..|  .|   |      .      || | ....|  | ||  |.| |  ||..|..|  .|. .|  
qeagknrykdvgcldnnrvklegpwpheyihanyvstptnpkrfictqaplektcadfwymclqdkveaifmlcnllekgakkcleyfaskdkdvlefee

-DFSIVLNKEAARKGYILRD--------ITVQRANAKGKRRLFQLQFTAWPDHGLPTSSAEMLTLVKEINNLKSrlvkpmPLLVHCSAGIGRTGVYILLE
 .  |..  |.. .  . .|        . |     . .|.  .  .  ||| |.|..   .| |...   .|       |. |||||||||||  ..||
kgqkisvkfessvtlkfrkdakakvtetvlviegpgekarkvthyhwidwpdrgvpaadlailellekarpskg......pivvhcsagigrtgsvvmle

LCLHQLQEKAKEVNIPAILSQLREQRMNLVQTQDQYKFVCGTVMA
  |.|| .  .  .   || ..|||| | .||..|| ||   .. 
yildqllagqiiedtdkilqkireqrnnsiqtdaqylfvhqviln
0046846 (Phosphotyrosine protein) phosphatases II 1787-1993 2.4e-34 114.0 In-house 7-168 (176) alignment 
Range on Protein: 1787-1993
Range on HMM: 7-168/176.0
LDSSNNDYINANHLSFESNGTTFSYIASQAKHFWQMVWEQQVRLICMLTTLVEGGRTKCHQYWPSAPGDTCqfgdfsivlnkeaarkgyilrditvqran
 .  . |||||| .     ..|.  . ..  .|..|..|...... .||..|| || ||..|||   .  .                             
gldldldyinanlilgsrpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgi.............................

akgkrrlfQLQFTAWPDHGLPTSsAEMLTLVKEINNLKSRlvkPMPLLVHCSAGIGRTGVYILLELCLHQlqekaKEVNIPAILSQLREQRM-NLVQTQD
        | ... ||||| |.. . .|.|...|..  ..     | ||||||||||||..... |. ..     | ...  .|...||||. . |||..
........qylhlpwpDhgvpdl.elllellefirealke...ggpvlVHCsaGigRtgtlvaayllele.....kglsveealalvreqRplgavqtpe

QYKFVCGT
||.|.   
Qyrflyef
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 1768-1994 1e-32 108.3 In-house 43-267 (288) alignment 
Range on Protein: 1768-1994
Range on HMM: 43-267/288.0
NAVRNRYRDILPYDDTRVKLDSSNNDYINANHLSFESNGT----TFSYIASQAKHFWQMVWEQQVRLICMLTTLVEGGRTKCHQYWPSAPGDTCQFGDFS
|..|.||...   | |||||.   . ||.|| .| . .      . . . .  . .|.|. |..|. | ||. |.| |. |  .|.||  |.. ..| . 
nptrdryenlprcditrvklsddpdfyiaanvvssakykrrlicaqaPlngtieelWkmllesdveyivmlcellekGkeksaeyfPsklGekarigrlc

IVLNKEAARKGYILRDITVQRANAKGKRR-LFQLQFTAWPDHGLPTSSAEMLTLVKEINNLKsrlvKpmPLLVHCSAGIGRTGVYILLELCLHQLQeKAK
 |  |. |    ...  ...  .   ..  . .| .  |.|.|.| .    | |.. ...|.    |  |..||.|||.||||  ||  . |..|.    
tvvkkkradidklvkvsllriskegeekvivkilhlleWdddgvPenylsplrllevlkslq....k..PivvhssaGvGrtgtlililialeslr.ldd

EVNIPAILSQLREQRMNLVQTQDQYKFVCGTV
 . |. .|..|||.|.. .||. || .|   |
flgirsllaklreerfkaiqtemqylyvhrcv
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 1768-1990 1.2e-32 108.1 In-house 41-269 (307) alignment 
Range on Protein: 1768-1990
Range on HMM: 41-269/307.0
NAVRNRYRDILPYDDTRV--KLDSSNNDYINANHLSFESNGTTFSY----IASQAKHFWQMVWEQQVRLICMLTTLVEGGRTKCHQYWPSAPGDTCQFGD
|. .|||.|.   | .|.  |.|    ||| ||.|    .   |        .   .|| |. ...|  . ||  ..| .. ||.||||   |..  ||.
ntdknryqdvkcqdkgrivvkfdglasdyihanylgiaikpkkficaqgplentqysfwamaiqekvesvimlckvielakikceqywpleegqklvfge

FS--IVLNKE----AARKGYILRDITVQRANAKGKRRLFQLQFTAWPDHGLPTSSAEMLTLVKEINnlksrlVKPMPLLVHCSAGIGRTGVYILLELCLH
 .  | ...      |    ..   |..   |.. | . .||.. |||.| |      . |.. ..       .  |..||||||.||.|  . . |   
apntisvanlgakklapdedlinvttlkvdwaqksrtiqhlqwenwpdrgvpqinltainlleavr......ydtnpvvvhcsaGvGrsGtivaislvqd

QLQEKAKEVNIPAILSQLREQRMNLVQTQDQYKFV
.. .     ..  .. .||.||   .||. || ..
kmiaGinckdmkklveelrsqrhyaiqteaqylyl
0049260 (Phosphotyrosine protein) phosphatases II 1815-1991 7.5e-32 105.5 In-house 21-143 (152) alignment 
Range on Protein: 1815-1991
Range on HMM: 21-143/152.0
QAKHFWQMVWEQQVRLICMLTTLVEGGRTKCHQYWpsapgdtcqfgdfsivlnkeaarkgyilrditvqranakgkrrlfQLQFTAWPDHGLPTSSAEML
 ...||.|..|.... | |||.|.| |. ||.||.                                             | ... ||||| |..|  .|
tladfwrmlkelgittivmltellelgklkceqyi.............................................qylhlpwpDhgvpdlsqlll

TLVKEINNLksRLVKPMPLLVHCSAGIGRTGVYILLELCLhqlqekaKEVNIPAILSQLREQRMNLVQTQDQYKFVC
 |.. |. |  .| |  | |||||||.||||..... |.|       . |..  .....||.|.. |....|..|. 
flllfiekl..aldkggpvlVHCsaGvgRtgtlvaaylml.......lgvsleeavalvrekRpgavpnpgqlrfly
0049772 (Phosphotyrosine protein) phosphatases II 1761-1991 1.6e-31 105.6 In-house 39-273 (314) alignment 
Range on Protein: 1761-1991
Range on HMM: 39-273/314.0
SLALKPENAVRNRYRDILPYDdTRVKLDS---SNNDYINANHLSFEsngttFSYIASQAKH------F----------WQMV--WEQQVRLICM------
  | ...|  .||| ||||.| .||.|..   |. |||||....        ..||.|..       |          |.||  ....|| | |      
lvadlflnrdknryldilpad.nrvilpglpvsgsdyinasyvdgf.....lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivmsrdevl

---------------LTTLVEGGrtkchqywpsapgdtcqfgdfsivlNKEAARKGYILRdiTVQRANAKGKRRLFQLQFTAWPDHGLPtSSAEMLTLVK
               |..| ..|                         |   |.    |.  ...  . . .|. ...  . .||.. | ... .. ...
adelsrLdaAlgKtpllildgng.........................neptaadlellk..eelydpelferlgikylripvpDgsap.lledfdefle

EINNLksrlVKPMPLLVHCSAGIGRTGVYILLELCLHQLQekakeVNIPAILSQLREQRM-----NLVQTQDQYKFVC
 |...     |. |.||||.||.||||..... .....|.     |..  .|...|..|.     .......|| |. 
fieea....dkggpvlvHCkaGkgRtgtfvvaaylmkllg.....vsleealedvrlkRpinpnpgfieqleqyefil
0043147 (Phosphotyrosine protein) phosphatases II 1790-1991 4.9e-31 103.1 In-house 3-154 (172) alignment 
Range on Protein: 1790-1991
Range on HMM: 3-154/172.0
SNNDYINANHLSFESngTTFSYIASQA------KHFWQMVWEQQVRLICMLTTLveggrtkchqywpsapgdtcqfgdfsivlnkeaarkgyilrditvQ
...|||||..|..     . ..|| |.       .||.|..|.....| .||.|                                             .
egsdyinasyldlyy..ipdrfiatqgplrntladfwrmlkelgithivnltel.............................................l

RANAKGKRRLFQLQFTAWPDHGLPtSSAEMLTLVKEINNLKsRLVKPMPLLVHCSAGIGRTGVYILLELCLhqlqekaKEVNIPAILSQLREQRMNLVQT
    . .|  .|.... ||||| | ... .| ... |..|   | .  | |||||||.||||. ... |.|       . ...  .....||.|.. ||.
ydpellerlgiqylylpwpDhgvp.llellleflefidell.alspggpvlVHCsaGvgRtgtlvaaylml.......lglsleeavalvrekRpgavqn

QDQYKFVC
..||.|..
psqyrfly
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 1768-1992 8.8e-31 101.7 In-house 55-283 (305) alignment 
Range on Protein: 1768-1992
Range on HMM: 55-283/305.0
NAVRNRYRDILPYDDTRVKLDS-SNNDYINANHLSFESNGTtFSYIAS------QAKHFWQMVWEQQVRLICMLTTLVEGGRTKCHQYWPSAPGDTCQFG
.  .|||.|.   | . ||||  |  ||| ||..          .|..         .|| || ...|  | ||   || |. || |||| | |.  .. 
aitknryqdvpcqdqsavkldkpspsdyihanyvgcpmipe.krficaqgpldqtidefwwmviqnkveqivmlcktvelgklkcaqywpaaqgeklelk

DFSIVLNKEAARKgyILRD----ITVQRANAKGKR--RLFQLQFTAWPDHGLPTSSAEMLTLVKEINNLKsrlvkpMPLLVHCSAGIGRTGVYILLELCL
   .| |   ..   . ||    ||. . .  |..   . .||.| ||| |.|      | |.  |   |      .|..|||||||||||  . .|  |
sgivvenvsgskp..merdaeiqitllnltysgdqkmsvrhlqwtewpdrgvppckltslellsairgsk......vpivvhcsagigrtgtivaieyil

HQLQEKAKEVNIPAILSQLREQRMNLVQTQDQYKFVCG
 .. |. .   .| ..  ||.||   .|.. || |.  
ekiaenkpcppmpelvkalrdqrafsiqndvqylfihr
subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 1759-1999 1.5e-30 101.1 In-house 26-271 (285) alignment 
Range on Protein: 1759-1999
Range on HMM: 26-271/285.0
DCSLALKPENAVRNRYRDILPYDDTRVKLDSSNNDYINANHLSFESNGTtFSYIASQ------AKHFWQMVWEQQVRLICMLTTLVEGGRTKCHQYWPSA
.|. .    |   ||| |.   ..||| |   . ||| |. . .  .    .||..|         ||.|......  . || ||.|||  ||  |.|  
nctytayeanpdlnryadvrcieetrvvlknhdrdyihaswmrmpgkdq.styittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekcalyypek

PGDTCQFGDFSIVLN--KEAARKGYILRDITVQRANAKGKRRLF--QLQFTAWPDHGLPTSSAEMLTLVKEINNLKSrlvKPMPLLVHCSAGIGRTGVYI
 |.  .|| . | |   || |  | ||  .||  ..      |.  ..|   |||.  |  .  |. | | .....    |  |. ||||||.|||  ..
lgevvkfgkyeitlteckeeaiagtilnaltvintedasseplymnhvqvpwwpdqlapedarpmielykwvkkvnp...kekpicvhcsagvgrtatfv

LLELCLHQLQEKAkEVNIPAILSQLREQRMNLVQTQDQYKFVCGTVMALSK
 .. .  .. |.  ....  |. ..|  |.. ||.. |. |.   .|    
gidyatirimenp.niemldivremramrfqavqshmqflflyvvlmeyfi
0051082 (Phosphotyrosine protein) phosphatases II 1793-1990 3.3e-29 96.8 In-house 4-145 (151) alignment 
Range on Protein: 1793-1990
Range on HMM: 4-145/151.0
DYINANHLSfeSNgttfsYIASQ--AKHFWQMVWEQQVRLICMLTTLVEGGrtKCHQYWPSAPgdtcqfgdfsivlnkeaarkgyilrditvqranakgk
||||.. .   ..     ...|.    .|.....|.... |..|....| |  .|..|.|..                                      
dyinfsyvt..gg.....lyrsggpladflellkelgiktivnlrseeerg..ycpeylpelg.....................................

RRLFQLQFTAWPDHGLPTSSAEMLTLVKEINNlksrlVKPMPLLVHCSAGIGRTGVYILLELCLHQlqekakeVNIPAILSQLREQRMNLVQTQDQYKFV
......... |||.|||.| ...| .......      |. |.|||||||.||||. ..| |.|..       |.. ..|...|..|...||. .|. |.
ievlhipildwpdpglplsfdavleflellld.....kkngpvlvHCsaGkgRTGtlvalylmllg.......vsleealeeyrlkrpgvvqpnqqflfq
PTPc_DSPc_SM00012 1895-1994 4.7e-29 96.0 In-house 4-103 (105) alignment 
Range on Protein: 1895-1994
Range on HMM: 4-103/105.0
QLQFTAWPDHGLPTSSAEMLTLVKEINNLKSRLVKPMPLLVHCSAGIGRTGVYILLELCLHQLQEKAKEVNIPAILSQLREQRMNLVQTQDQYKFVCGTV
....|.|||||.|..| ..|.|...... |.   .  |..||||||.||||....|...|.||... |||.|  |...||.||...|||..|| |..  .
hyhytgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqylflyral
0044763 (Phosphotyrosine protein) phosphatases II 1779-1991 8.4e-29 95.9 In-house 1-164 (178) alignment 
Range on Protein: 1779-1991
Range on HMM: 1-164/178.0
PYDDTRVKLDSSNN----DYINANHLSfeSNGTTFSYIAsqaKHFWQMVWEQQVRLICMLTTLVEGGRTKCHQYWPSAPGdtcqfgdfsivlnkeaarkg
|.|.|||.|..  .    |||||..     .    |. .    .......|. ...|..||. .|.|. ||..|||.  |                    
pldrtrvllsnleglersdyinaseil..pglylgslpp...addlellkelgithivnlteelelgflkcdpywpeeag....................

yilrditvqranakgkrrlFQLQFTAWPDHGLPTSSAEMLTLVKEINNLKSrlVKPMPLLVHCSAGIGRTGVYILLELCLHQlqekakEVNIPAILSQLR
                   .| ... .|||| |.... .| .|. |... .   |. | |||||||.||.|. ... |....       ..........|
...................iqylhipipDhgvpdllehflefvefieeald..ekggpvlVHCsaGvgRsgtlvaaylmkkl......glsleeaielvr

EQRMnLVQTQDQYKFVC
|.|.  |....|.....
erRp.ivpnpgqlrqLy
subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 1757-1992 6.5e-27 88.9 In-house 26-263 (281) alignment 
Range on Protein: 1757-1992
Range on HMM: 26-263/281.0
SRDCSLALKPENAVRNRYRDILPYDDTRVKLDS-----SNNDYINANHLSfeSNGTTFSYIASQA------KHFWQMVWEQQVRLICMLTTLVEGGRTKC
|  |.   .| |  .||| .|   | .||.|          ||| ||..   |      || .|         ||.|.|...   | ||  ..|  | ||
sdlctvfnqpvnnkknrylnipcldisrvqlkvkmpnknstdyihanyir..spflkrgyiltqgpkketradfwrmiwqenttaivmlcqfletnrekc

HQYWPSAPGDTCQFGDFSIVLNKEAARKGYILRDITVqraNAKGKRRLF-QLQFTAWPDHGLPTSSAEMLTLVKEInnlKSRLvkpMPLLVHCSAGIGRT
 .|.|       ||  .|.  .  .  |  .   . .     .|. ||  .  .  |||  .| ||  || ....|   ..|     | ..|||||.||.
aeyfprnahcclqfdklsvsyedstvnkslvttrlnl...syegetrlithwlwkewpdwqvpessevmlkilrki...rars...tppvihcsagvgrs

GVYILLELCLHQLQEKAKEVNIPAILSQLRE-QRMNLVQTQDQYKFVCG
|  . .|..|. .. .    .|  |.|.||   |   ||| .|| ..  
gtlmaveialqsihshftlpdikqivshlrvtgraasvqtlqqymliwk
subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 1795-2001 7e-27 88.9 In-house 78-285 (301) alignment 
Range on Protein: 1795-2001
Range on HMM: 78-285/301.0
INANHLSFEsnGTTFSYIAS------QAKHFWQMVWEQQVRLICMLTTLVEGGRTKCHQYWPSAPGDTCQFGDFSIVLNKE--AARKGYILRDITVQRAN
| || .. .  | .  .||.       .. || |.   .|  | ||.  ||   .||..| |. .... . | |.| ....    .|  . | . |. . 
ihanwipts..GhphrfiatqgPlkntsedfwamlvqydvekivmlgqkvekleekceeylpvkisekldigrfkikiknkelilnkkiskrtlevedst

AKG-KRRLFQLQFTAWPDHGLPTSSAEMLTLVKEINnlKSRlvKpmPLLVHCSAGIGRTGVYILLElCLHQLQEKAKEVNIPAILSQLREQRMNLVQTQD
 |   | .   |.. |.|.|.| | ||.  |.. .   ||.  |  |..|||||||||.  .|  | .| .  |  .....   | .|||.| | |||. 
gkfatrtvthyqysewtdrgvPkshaelfdlmelvk..kse..k..PivvhcsaGiGrsvafigte.ylareveadptieltealkhlrehrwngvqtns

Q-YKFVCGTVMALSKGA
| |    |||  |.|  
qlywmtlGtvyrlikey
subfamily_ptpA1_pd Subfamily ptpA1 1760-1962 3.3e-26 87.0 In-house 39-261 (418) alignment 
Range on Protein: 1760-1962
Range on HMM: 39-261/418.0
CSLALKPENAVRNRYRDILPYDDTRVKL----DSSNNDYINANHLSFES---NGTTFSYIASQAKHFWQMVWEQQVRLICMLTTLVEGGRTKCHQYWPSA
 |   |  |. .||| .||| . |||.|    |   .||||||..          |   .      ||.||||...|.| ||.   |  | || .|||  
tsegdkkhntsknrytnilpvnhtrvqlkkiqdkegsdyinanyidgaypkqfictqgplpntiadfwrmvwenrcriivmlsresencrikcdrywpeq

PGDT---------CQFGDFSIVLNK--EAARKGYILRDITVQraNAKGKRRLFQLQFTAWPDHGLPTSSAEMLTLVKEINNLKSRLV----KPMPLLVHC
 |             || .|. | .  .   .  | |.| .        | . | |.  |||| .|  .  .  |.. | | . ...    . .|..|||
iggeqfsiygngnevfgtysvelveviqdpereiitrnirlt..fegetrditqyqyegwpdhnipdhtqpfrqllhsitnrqnqiipssdrnvpiivhc

SAGIGRTGVYILLELCLHQLQEKAK
|||.|||| .    . ...|.   |
sagvgrtgtfctavimmkkldhyfk
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 1758-1990 2.3e-25 84.1 In-house 23-251 (267) alignment 
Range on Protein: 1758-1990
Range on HMM: 23-251/267.0
RDCSLALKPENAVRNRYRDILPYDDTRVKLDSSNNDYINANHLSFESNGTtfSYIASQ------AKHFWQMVWEQQVRLICMLTTLVEGgrtKCHQYWPS
  .|  .  .|. |||. | |||||||| |  ....|||| ..     .    .|. |        .|.... .|.|  | .||.  ..   . ...|| 
stisqsiaeknqernrlddnlpyddtrvilrtkeeeyinasyvegyktkn..afivtqdplkntitdfltvihdqkvpvivlltkvftd...nirlfwPP

APGDTCQFGDFSIVLNKEAARKGYILRDITVQRANAKGKrRLFQLQFTAWpdhGLPTSSAEMLTLVKEINNLKSRLVKPMPLLVHCSAGIGRTGVYILLE
  |.. .. |...  . |   . | .  . ..  |   .  .    .  |    . |     |  .  |   .       ||.|.||.|.||.| .. ..
kmgqakkyqdltvehslekeendyqiitlelkfknesah.nvtlyyykkw...nintnnkpylkplfgilaknqlengnrPlvvacsdGvGrsGtflvid

LCLHQLQEKaKEVNIPAILSQLREQRMNLVQTQDQYKFV
  |.....    ..|   | ..|.||. ||.|...| ..
sqlerakte.gvsdifdflrkirsqriglvdtkeryiyi
0048076 (Phosphotyrosine protein) phosphatases II 1847-1992 2.5e-24 81.0 In-house 1-137 (145) alignment 
Range on Protein: 1847-1992
Range on HMM: 1-137/145.0
QYWPSAPGDTCQFGDFSIVLNKEAARKGYILRDITVQRANAKGKRRLFQLQFTAWPDHGLPTSSAEMLTLVKEINNLKSRlvkPMPLLVHCSAGIGRTGV
.||||   .   .|..  .|. |  ..  | . ... .     .|  .|.... ||||| |.... .|.... |... ..   . | |||||||.||||.
pywpseilpglylgslptaldlellkdlgittvlnltselellerlgiqylylpwpDhgvpdllellleflefieealke...ggpvlVHCsaGvgRtgt

YILLELCLHqlqekaKEVNIPAILSQLREQRMNLVQTQDQYKFVCG
.... |.|.      . |... .| ..|.||.. |....|..|.. 
lvaaylmll......lgvsleealelvrsqrpgavpnpgqlrflye
subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 1758-2000 2.7e-24 80.3 In-house 40-292 (310) alignment 
Range on Protein: 1758-2000
Range on HMM: 40-292/310.0
RDCSLALK--PENAVRNRYRDILPYDDTRVKLD---SSNNDYINANHLSFESNGTTFSYIASQAKH----FWQMVWEQQVRLICMLTTLVEGGRTKCHQY
.| ||. .   ..  .||| |..  |..||||    |  .||| ||..  .   .||       .|    ||.|.....   | .|   .| || ||  |
qdssltyeaykkymhknrysdvvcldtsrvklkidksryedyihanyvktnylrstficsqgplqhtiidfwrmifqeraesilllckvgeegrpkcvgy

WPSApGDTCQFGDFSIVLNKEAARKG--------YILRDITV--QRANAKGKrRLFQLQFTAWPDHGLPTSSAEmlTLVKeinNLKSrLVKPMPLLVHCS
|||  | |  .|   .    |.. .         ..  .. |  | || |.  |.  ...  ||| |.|       |. .    | .  |.  | .||||
wpsl.gvtetygcirvtnlsesseefeicnlavtfvpdnvpvdeqpanlkel.rvslikwpnwpdrgvpdekch..tvpq...rlla.qvrhgpcvvhcs

AGIGRTGVYILLELCLHQLQeKAKEVNIPAILSQLREQRMNLVQTQDQYKFVCGTVMALSKG
||..|..| . |.| ...|. . ..|..  . ..|. .|.  .||. || ..    .....|
agkdrlyvvvalklkidkld.rglkvdaeevktellksraiciqtelqyliidrvriifarg
subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 1756-1996 2.8e-23 77.1 In-house 33-274 (312) alignment 
Range on Protein: 1756-1996
Range on HMM: 33-274/312.0
KSRDCSLALKPENavRNRYRDILPYDDTRVKLDSSNNDYINANHLSFESNGT----TFSYIASQAKHFWQMVWEQQVRLICMLTTLVEGGRTKCHQYWPS
   .|.  ||  .   ||| .|  .|  |  |   .| || || .   ..      | . . . . ||||..       | .|...|| |  || .|   
sdsectaflkfkd..lnrypniqcwdrgrftlagdenfyihanfvkictkperfvctqgplentcthfwqlalslgstsiillcgfvedgsekcakyisd

APG-----DTCQFGDFSIVLNKEAARKGYILRDITVQRANAKGK-RRLFQLQFTAWPDHGLPTSSAEMLTLVKEINNLKsrlvKpmPLLVHCSAGIGRTG
  |     |   . ..   ..     |  |   .     .| |.  .| . |...|||||.| |    | |.  ... |    |  |.. |||||.||||
ivgfvdledhrvyteycteieiggkskdkithrvlkvvvkatgqesklnhyqwaswpdhgmpdscdtalrllsavkkdk....k..pviahcsagvgrtg

VYILLELCLHQLQEKAKeVNIPAILSQLREQRMNLVQTQDQYKFVCGTVMA
  .|.|  .  |.   |  |.  ..  || .|   |..  || ..  .|. 
tlaliesmiaalrhprk.qnvkdsfvllrkdrarsvrvfpqyvyalrcvle
subfamily_CG42327_pd Subfamily CG42327 1766-1925 9.8e-23 75.3 In-house 26-196 (319) alignment 
Range on Protein: 1766-1925
Range on HMM: 26-196/319.0
PENAVRNRYRDILPYDDTRVKLDSS----NNDYINANHLSFESNgTTFSYIASQA------KHFWQMVWEQQVRLICMLTTLVEGGRTKCHQYWPSAPG-
.    ..|. ...|  .||| |..     .. |..|...    . .  ||||.|.        ||..||||| | |  || | | |  .| .|.|.  . 
vtskdksrvinvvPlPetrvvlqrigdddkdeyldasyvrGydd.apnsyiaaqvsledsssdfwrtvweqqsrvivqltdlselGikvcaeylPtketl

-DTCQFGDFSIVLNKEAARKGYILRDITVQRANAKGKRRLFQLQFtAWPDHGLPTSSAEMLTLVKEINNL-KS
 .|  .||. . | . .... |..  . ..| . .  | |    .  |.. ..|.. | ..... |...  ||
dntslyGdilvtlkgrevkdryaistlllkrvdkeesrelthywy.kwleaevPaeeaaliamllevrsslks
0048179 (Phosphotyrosine protein) phosphatases II 1848-1991 1e-21 72.6 In-house 2-138 (144) alignment 
Range on Protein: 1848-1991
Range on HMM: 2-138/144.0
YWPSAPGDTCQFGDFSIVLNKEAARKG--YILRDITVQRANAKGKRRLFQLQFTAWPDHGLPTSSAEMLTLVKEINNLKSrlvKPMPLLVHCSAGIGRTG
..||   .   .|..  .|. |  .|   . . ..| .. ..  .|  .|.... ||||| |.... .|.... |... .   .. | |||||||.||||
snpseilpglylgslptaldlellkklgittvinlteeyepefleregiqylhlpwpDhgvpdllellleflefieeale...eggpvlVHCsaGvgRtg

VYILLELCLhqlqekAKEVNIPAILSQLREQRMNLVQTQDQYKFVC
..... |..       . ...  .| ..|..|.. |....|..|..
tlvaaylmk......klglsleealalvrsrrpgavpnpgqlrfLl
subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 1814-1990 1.1e-20 68.3 In-house 102-280 (302) alignment 
Range on Protein: 1814-1990
Range on HMM: 102-280/302.0
SQAKHFWQMVWEQQVRLICMLTTLVEGGRTKCHQYWPSAPGDTCQFGDFSIV-------LNKEAARKGYILRDIT--VQRANAKGKRRLFQLQFTAWPDH
|  . .| .. . .| ..  |...||..  || .|.    |.. .|| ...        |.. . .|.. |  .    .. . | |. .  |.|.|||||
stlekhwalieqynvaivvqlcsfvedeekkcaeyysdkvggelkfgrytvktvsvktdleeftdkksfklytveiknekkkkkvkktvdilafsawpdh

GLPTSSAEMLTLVKEINNLKSRlvkpmpLLVHCSAGIGRTGVYILLELCLhQLQEKAKEVNIPAILSQLREQRMNLVQTQDQYKFV
| |  .   | ..|  .  |        .|||||||.||||  . .   . ||  | |  ..  |.  .|. |   ||...|  ..
Gapkeaytaldilkfcesykkn......vlvhcsaGvGrtGtlvaikyGi.qlcskkkvtdllsivlpvrqcryGavqdeqqliyl
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 1764-1851 1.5e-19 64.9 In-house 43-152 (350) alignment 
Range on Protein: 1764-1851
Range on HMM: 43-152/350.0
LKPENAVRNRYRDILPYDDTRVKLD------------SSNNDYINANHLSFE----SNGTTFSYIASQA------KHFWQMVWEQQVRLICMLTTLVEGG
   |   .|||..||||. .||||              | |||||||.|. .    .  . | ||| ||      . |.... . .|..| .||..|| .
eGvelfaknrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvkvilsltsdveln

RTKCHQYWPS
. ||..||. 
lekcyrYWqe
subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 1752-1996 5.1e-19 63.4 In-house 13-219 (255) alignment 
Range on Protein: 1752-1996
Range on HMM: 13-219/255.0
RGLVKSRDCSLALKPENAVRNRYRDILpyddtrvkldssnndyinanhlsfesngttfsyiasQAKHFWQMVWEQQVRLICMLTTLVEGGRTKCHQYWPS
| |.    |.  .|||. ....  ..|                                      ..|.|..  ..   . ||. . | |. ||..|.| 
rilidedvctehvkPekdkkrknlysl....................................tvdkfyqtivqtktevvvmlcdfaeegvekcssyfpl

APGDTCQFGDFSIVLNKEAARKGYILRDITVQRANAKGKRRLFQLQFTAWPDHGLPTSSAEMLTLVKEINNLKSrlvkpmpLLVHCSAGIGRTGVYILLE
   .  .. | ...  | .|      ..|| . .. |  . .   ... |...  |  . |.| ..| . . ||       ..||||.||||.  ..| |
ekdeklkladvnvtttkssadvvlrtleitstlgekkkthtvkhysykGWieknaPelareilnilkvvrdsks.......vvvhCstGiGrsaafvlae

LCLH----QL-QEKAKEVNIPAILSQLREQRMNLVQTQDQYKFVCGTVMA
|       .| . .. |..   .| .||..|   ..|  |  |   .|. 
lvyqkmirsldttetveldylslleelrskrkraihtPlqlafsilmvld
subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 1791-1997 1e-18 62.5 In-house 45-258 (290) alignment 
Range on Protein: 1791-1997
Range on HMM: 45-258/290.0
NNDYINANHLSFESNGTTFSYI----------ASQAKHFWQMVWEQQVRLICMLTTLVEGGRT----KCHQYWPSAPGDTCQFGDFSIVLNKEAARKGYI
|.||| ||.... ..                 .|  ..|| |. . .|. . ||    |  .      | .| | . |.  .|.....   .  . .. .
nddyiHAnrvtcpnglrliltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCakYvpesvgeelkfkgltvkCkskekeddve

LRDITVQRANAKgKRRLFQLQFTAWPDHGLPTSSAEMLTLVKEINNLKSrlvkpmPLLVHCSAGIGRTGVYILLELCLHQLQEKAKEVNIPAILSQLREQ
 | ..|.  . . .  .   ..  | .   . ..  .|.|.. ... |.      | .|||  || |  .   ..|    . |. ..|.. ..|..||.|
tRelvvkfddee.eftvtHsllkgWnklnvqedtktllsliqkvkaskt......pvivHcvdGiSrsAalaaiilgyQkiaetsgsvkledvlkalrkq

RMNLVQTQDQYKFVCGTVMAL
| ...... .. ||   .. |
ralaitsalelafvdagivll
subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 1767-1991 2.4e-18 60.6 In-house 50-278 (302) alignment 
Range on Protein: 1767-1991
Range on HMM: 50-278/302.0
ENAVRNRYRDILPYDDTRVKLDSSNNDYINANHLSFE--SNGTTFSYIASQAK-----HFWQMVWEQQVRLICMLTTLVEGGRtKCHQYWPSAPGDTCQF
.|  .|.  |.  .|...|||. ....|.|| ...    .. .  . .. .       .||.||.....  . .|    |  .   ....|   ||  ..
knlkknqsedvpildsnlvkleaepdsyvnaskvevPeltrsiilaQlpkvdsedsveeFWrmvfqekivsvvilvgeeelkk.tlselfpkksgdykey

GDFSIVL----NKEAARKGYILRDITVQRANAKgkrrLFQL-QFTAWPDHGLPTSSAEMLTLVKEInnLKSRLVKPMPLLVHCSAGIGRTGVYILLELCL
|.. .      ..|.... |..  .    .|.     | ..  .| |...  |.. ||. . ....   ..      ....    |.|| |. . | . .
gkmfvNnrkVekaeeektryviEvlPegcsnsv....lanvyvltnWkqkkvpvkyaeliktaakv..fakkikadentvivSknGaGRagafltlavav

HQLQEKaKEVNIPAILSQLREQRMNLVQTQDQYKFVC
..||.. ||.||  |. ..|.|| . |.. .|| .. 
eklqkg.kepnikeivksiRsqRpravdslkQyvsly
subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 1768-1992 2.8e-18 60.6 In-house 47-273 (303) alignment 
Range on Protein: 1768-1992
Range on HMM: 47-273/303.0
NAVRNRYRDILPYDDTRVKLDSSnnDYINANHLSFESNGT---TFSYIASQAKHFWQMVWEQQVRLICMLTTLVEGGRTKCHQYWPSApGDTCQFGDFSI
|  .||. |..  | ..|||  |   || |..| ..|.     |   ..  |  ||||. ||.|. . .| |  |  .   .  .|    |  .| . ||
nmdknrfvdvicldhskvklsds..syihasyleldsskkailtqlplshtaadfwqmiieqkvkcvlllltdseydklggdsvfprn.qdflkfeersi

VLN---KEAARKGYILRDITVqrANAKGKRRLFQLQFTAWPDHGLPTSSAEmlTLVKEINNLKSRLVK---PMPLLVHCSAGIGRTGVYILLELCLHQLQ
 .    .    .|. |. ..|  .| . |  |   .. |||   .|. ..    .||.| .|.| | |     | .    .| ||.| . |.| .   |.
rvgefkrvelgdgwvlkvlsv..sngdyksflhvhhykawphnsipsdgsp..kfvkqiwqlqsvlrkysdstptvymslsgcgragtfalfetahlslh

EKAKEVNIPAILSQLREQRMNLVQTQDQYKFVCG
..   ...   | ..|. |.  ||   |. .|  
seqasldlvkclenvrngrlhavqnlsqfsvvyt
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 1889-1995 1.8e-16 54.5 In-house 87-191 (440) alignment 
Range on Protein: 1889-1995
Range on HMM: 87-191/440.0
GKRRLFQLQFTAWPDHGLPTSSAEMLTLVKEINNLKSRLvKPMPLLVHCSAGIGRTGVYILLELCLHQLqEKAKEVNIPAILSQLREQRMNLVQTQDQYK
  | | | .. .|||.|.|  .. .| .....|. . .     ||||||||| ||||| | ..  |..  ... ...| .... .|..| ..||| .|| 
esrtlkqyhyqgwpdkgvpkfagpvlkmiqdvnesqeka.gngpllvhcsagagrtgviiavdsilrea.krsdqidifsfinsmrnnrpqmvqtpeqya

FVCGTVM
||  .|.
fvheavl
subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 1816-1990 2e-16 54.7 In-house 17-195 (198) alignment 
Range on Protein: 1816-1990
Range on HMM: 17-195/198.0
AKHFWQMVWEQQVRLICMLTTLVEGGRTKCHQYWPSAPGDTCQFGDFSIVLNKEAARKGYILRDITVQ--RANAKGKRRLFQLQFTAWPDHGLPTSSAEM
   |||||||     | |.        .    |||..   | ..| .|.. .  ...  | .  . .    .     | . . |||.| ..  |  .  .
ladfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqftswkekttpnvalfv

LTLV--KEINNlKSRLVKPMPLLVHCSAGIGRTGVYILLELCLHQLQE-KAKEVNIPAILSQLREQRMNLVQTQDQYKFV
  .|  .|. . |    |  |..|||| | | |||.. |.. .   .| |.  |..  .  .||. |  .. . ..|.|.
gfvvasrevsk.kyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfi
subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 1816-1990 2.1e-16 54.7 In-house 18-196 (199) alignment 
Range on Protein: 1816-1990
Range on HMM: 18-196/199.0
AKHFWQMVWEQQVRLICMLTTLVEGGRTKCHQYWPSAPGDTCQFGDFSIVLNKEAARKGYILRDITVQ--RANAKGKRRLFQLQFTAWPDHGLPTSSAEM
   |||||||     | |.        .    |||..   | ..| .|.. .  ...  | .  . .    .     | . . |||.| ..  |  .  .
madfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqftswkekttpnvalfv

LTLV--KEINNlKSRLVKPMPLLVHCSAGIGRTGVYILLELCLHQLQE-KAKEVNIPAILSQLREQRMNLVQTQDQYKFV
  .|  .|. . |    |  |..|||| | | |||.. |.. .   .| |.  |..  .  .||. |  .. . ..|.|.
gfvvasrevsk.kyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfi
PDZ PDZ domain (Also known as DHR or GLGF) 1082-1158 3.2e-16 49.4 Pfam-A 3-80 (81) alignment 
Range on Protein: 1082-1158
Range on HMM: 3-80/81.0
TLLA-RDGKYGMGIRGGADSK-TPVLISRIAEGSAAADEPqIQIGEEITHINGTDVTQLTHAEVLALIKSSPSSLNLVI
.| . . |. |. . || | . ... .|.. .|.||.  . ...|  |. .||.||....|.|. ..||.. ... |.|
slekekrgglGfslkggsdkrdkgifvsevvpggaaeadg.lkeGDkIlsvNgvdvenvshdeavqaikgkkgevtLti
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 1892-1992 1.3e-15 52.0 In-house 216-338 (350) alignment 
Range on Protein: 1892-1992
Range on HMM: 216-338/350.0
RLFQLQFTAWPDHGLPTSSAEMLTLVK----EINNLKSRL----VKPMPLLVHCSAGIGRTGVYILLELCLH------QLQEKAKEVN--------IPAI
 ..|||.  |.| .|     ..|. ..     |..| ...     .  |.|||||||.||||... |.  |.      .|... ....        |  |
vvyqlqvknWkDlslllnPesilqalevkndliddlfaeshldnarsspilvhCsaGvGrtGtlvtlDsllsdfeilenltkesrkldvaaktrDlisii

LSQLREQRMNLVQTQDQYKFVCG
. .||.||...||. ||. |.  
vnelrkqrismvqnldqfifiYe
subfamily_hpo-7_pd Subfamily hpo-7 1752-1995 1.5e-15 51.9 In-house 16-224 (263) alignment 
Range on Protein: 1752-1995
Range on HMM: 16-224/263.0
RGLVKSRDCSLALKPENAVRNRYRDILpyddtrvkldssnndyinanhlsfesngttfsyIASQAKHFWQMVWEQQVRLICMLTTLVEGGRTKCHQYWPS
| |.    |.  .|||. .. .  ..|                                 .  . . |.|..  ..   . ||.   | |. || .|.| 
rilidedvctehfkPekdkkrknlysl.................................lvqtidkfyqtivqtktevvvmLcDfneegvekcssyfPl

APGDTCQFGDFSIVLNKEAArkGYILRDITV--QRANAKGKRRLFQLQFTAWPDHGLPTSSAEMLTLVKEINNLKSrlvkpmpLLVHCSAGIGRTGVYIL
   .  .. . ...  |       .|. . .  .  . |  . . . ... |...  |. . |.| ..|   |.||       | ||||.||||.  . .
ekdekqklanvnvcttkvqs..dvllktlellstlgeKkkthtvkhysykgWiekndpelareilnilkvarnsks.......lvvhcstGiGrsaafsv

LELCLH----QL-QEKAKEVNIPAILSQLREQRMNLVQTQDQYKFVCGTVM
 ||       .| . .. |..   .| .||..|   ..|  |  |   .|.
aElvyqkmirsldttstveldylsLleelrssrkraihtPmqLafsilmvL
subfamily_eak_pd Subfamily eak 1762-1995 2.1e-15 51.0 In-house 46-302 (332) alignment 
Range on Protein: 1762-1995
Range on HMM: 46-302/332.0
LALKPENAVRNrYRDILPYDDTRVKLDSSN---NDYINANHLSFESNGTTFS--YIASQ--AKHFWQMVWEQQVRLICMLTTLVEGGRTKCHQYWPSAPG
 . . |.  ||   .|.|||   |.| ||    . ||||  . |   |  .    |||.     ||||| ||.   | .|   || .  |  .|.|    
etarleavnrn.vvkivpydrylvrltssqlnrlGyinaslaefsevGrkyiltGiasedkvfafwqmvleqkspaivqlledvelkleksdkyfpdktr

DTCQFGDFSIVLNKEAARKGYILRDITVQRANAKgkRRLFQLQFTAWPDHGLPTSSAEM-----------LTLVKEINNLKSRLVKP-------MPLLVH
.  .|| . .   .   |. .  | . ... |     |..  ..  | .  ||     .           | |.   ..| | ..|        .  .. 
eelkfGildverkefvkrniletrllelskGnet..hrvlhykvfGwtettlpkyedflalrkvmkevGvlllivmksallsstlkkyihtppsfapiiq

CSAGIGRTGVYILLELCLHQLQEKAKEV-NIPAILSQLREQRMNLVQTQDQYKFVCGTVM
.. |  |.||.....| .. ...| |..  .  .. . ...|.  | .. |. |.   |.
sarGsaraGvfvvidllirlidnkkknlysvedlilkvkskrihsvlvalqhsfiyeivl
subfamily_CG42327_pd Subfamily CG42327 1932-1998 1e-14 49.0 In-house 249-315 (319) alignment 
Range on Protein: 1932-1998
Range on HMM: 249-315/319.0
PLLVHCSAGIGRTGVYILLELCLHQLQEKAKEVNIPAILSQLREQRMNLVQTQDQYKFVCGTVMALS
|| |||| |.||||. |  .. ...|.|  . |.|| ..|..|..| . |.|..||.|.  ..   .
PlvvhcsdGvGrtGlviasdiairsleeskrsvdiPqlvssvrrdrasavltkeqyefiykvlseya
FERM_M FERM central domain 93-202 1.1e-14 44.9 Pfam-A 1-126 (126) alignment 
Range on Protein: 93-202
Range on HMM: 1-126/126.0
DPRQLQHDHTRFLYYCQLKEDLASGRFVAPHDVCWQLCAYIVQADIGDFN-ISRCPEGYLSDML-------LLP-------DQKPED-EDEIRNLHVQLE
|| ....  .. |.|.|.|.|| ..|. .. . ...| |. .|...||..  .. ....| . .       |||        .| .. | .| . | ...
dpnpkydevrinllYeQakwdlleerldcteeeallLAALqlqiekgdseeeekasssdlekeeeeaeseqllpvsprllkkekskqleqrileahknva

DMTADEAMLAFLELASQQLLYGLDIH
.....||.| .|..|..   ||.. .
glslaeaklkylqaaqslpdyGvslF
subfamily_egg_pd Subfamily egg 1768-1995 4.9e-14 46.7 In-house 40-267 (307) alignment 
Range on Protein: 1768-1995
Range on HMM: 40-267/307.0
NAVRNRYRDILPYDDTRVKLDSSN----NDYINANHLSFESNGTTFS----YIASQAKHFWQMVWEQQVRLICMLTTLVEGgrTKCHQYWPSAPGDTCQF
|  . | . .   | .||||.  .    .|.| ||... .    .|      .    . ||.||....|. | |||. .|    .|. ||| |. |. ..
nlekarskrvhckdssrvklelrrGqylddfihanrvkGkpllnefilaqaplkntvddfwrmvfqeevqyivmltsrkes..erceyywpkaesdslvt

--GDFSIVLNKeAARKGYILRDITVQRAnAKGKRRLFQLQFTAWpDHglpTSSAEMLTLVKEINNLKsRLvkPMPLLVHCSAGIGRTGVYILLELCLHQ-
  | . |   |   .|   |  .|  .    |..    |.   . |      |... . .. .  |. .|    | .|..  |. .... . .|. | . 
vpGslrienlk.vdskadplfrvtklkl.vGgddeerflehwqg.dv...nnssdvysplrvlrklr.nl..skpvvvqdilGvskaatlvaieiallsl

LQEKAKEVNIPAILSQLREQRMNLVQTQDQYKFVCGTVM
|.       .      || .|   |..  .| ||   |.
lrGpitkslvlravvflrlrrrlsvesvllylfvyrlvl
PDZ PDZ domain (Also known as DHR or GLGF) 995-1074 3.7e-12 36.4 Pfam-A 2-80 (81) alignment 
Range on Protein: 995-1074
Range on HMM: 2-80/81.0
IRIPRTiAGYGFGFREGSESWCQ-NLPVVTSITAGGAAHLDGrLQSEDVLVEVNGKGLASKSYVEVLTMIRGHSGALRMTV
.....   . |.||.  ..|... .  .|... .||||. || |.  |....|||. ... |  |.  .|.| .| ...|.
vsleke.krgglGfslkggsdkrdkgifvsevvpggaaeadg.lkeGDkIlsvNgvdvenvshdeavqaikgkkgevtLti
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 1892-1991 2.2e-10 34.4 In-house 219-337 (349) alignment 
Range on Protein: 1892-1991
Range on HMM: 219-337/349.0
RLFQLQFTAWPDHGLPTSSAEMLTLVK--E--INNLKSRLV----KPMPLLVHCSAGIGRTGVYILLELCLH---QLQEKAKEVNIP--------AILSQ
 |.|||.  |.| .|      .|. ..  .  |..| .||     .  .|||||||| |||||.. |.| |     ||..   ....         |. .
ellqlqvknwldlslllnPisilqalevkndliddlfarlyldtdqlstllvhcsaGcGrtGvlvtldlllsileplqnesnkiklqallkDlisiivne

LREQRMNLVQTQDQYKFVC
|| ||...||   |. .. 
lrkqrismvqnlaqfiaiy
Guanylate_kin Guanylate kinase 699-868 3.5e-09 23.7 Pfam-A 3-180 (183) alignment 
Range on Protein: 699-868
Range on HMM: 3-180/183.0
RPVVLLGA---GKANVEAALLERFPDAYRLVRHDATD--SHG--EAESYRFVDLDTFIHQAMRDEYAEVVRYGSDLYGLPYASLRT-DEDGRHpVIPICD
||.||.|.   || ... |||...|. . .     |   ..|  . . | ||. . . ..  ..|. |  .. . |||   .. .   | |.. ||  .|
rplvlvGpsgvGkstlkkaLldelpekfgisvshtTrdkrkgevdGkdYfFvskeelekdiskneflEaaefsgnlygtsveeieevlesgki.viLDvd

PLVITTLQKHGVFPIVIFLDCDTSRRARLVMPHDSASRVHAEVQLAAKVKSHFHAY--FSGqVFPANSLEDVAEVVHEVV
.  .  |.|  . ||..|.   . . ..  . . . .  .   . ......... |  |.  |   ..|..  . ..|..
iqgvkqlrkaelspilvFIkppslkelqrrlksrgkeqeekiakrleaaekelqeyaeFdv.vivnddldealkklkeil
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 1765-1850 4.5e-09 30.1 In-house 45-154 (349) alignment 
Range on Protein: 1765-1850
Range on HMM: 45-154/349.0
KPENAVRNRYRDILPYDDTRVKLDSS------------------NNDYINANHLSFESNGTTFSYIASQAK------HFWQMVWEQQVRLICMLTTLVEG
  |   .|||.|||||. .||||  |                   .||||||.|..    . . ||| ||        |....  ..|.|.  |.   | 
GvelfaknrykdilPyehsrvklkkslksskvikastsesdsgklddyinanylkltrisvekkyiatqaPlPstvddfykvillngvklvlsLnddkel

GRTKCHQYWP
.  ||..|| 
slekcdiywq
FERM_C FERM C-terminal PH-like domain 213-295 6.2e-09 26.3 Pfam-A 8-89 (90) alignment 
Range on Protein: 213-295
Range on HMM: 8-89/90.0
YIGIGWRGIRIMSDTMAT-VEFFPWARFQMITFDNRVVDLVTKGqlNGPDTHNVVTCTTKQHAQALWIAGVQRHTFFRRRRQPQ
..|.  .|. |....     . |||.. . ..|...   . ..   .  ..    ...... .. |.   .. |..|||||...
lLGvdakGlliyeknsklsnksFpWseirklsfkekkftiklrd..ekkkdvlkFyssqlrvnklllklcienhdlfrrrrkvd
subfamily_PTPDC1_pd Subfamily PTPDC1 1899-1991 5.2e-08 27.5 In-house 88-169 (182) alignment 
Range on Protein: 1899-1991
Range on HMM: 88-169/182.0
TAWPDHGLPtSSAEMLTLVKEINNlksrLVKPMPLLVHCSAGIGRTGVYILLELCLHQLQEKAKevnipaILSQLREQRMNLVQTQDQYKFVC
 .|.|.| . |  ..|..|| ..      ..   . ||| || ||||| |   |  ..  . .|       .. .|..| . .||..| ..| 
fgwkDygva.sleriLdivkvvaf....alqegkvavhChaGlGrtGvliacylvyakrltaek......aiklvrskrpksiqtreqvelvk
PDZ_2 PDZ domain 1092-1143 1e-06 18.2 Pfam-A 3-54 (82) alignment 
Range on Protein: 1092-1143
Range on HMM: 3-54/82.0
MGIRGGADSK-TPVLISRIAEGSAAADEPqIQIGEEITHINGTDVTQLTHAEV
.|..   ... . ||.  ..|.| ||..  ...| .|....|..|. ||. . 
iGvsvsqlentrgvlvvsVkessPaakag.lkpGDiilkvdgkkvksltdlks
subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 1764-1905 2.7e-06 21.2 In-house 92-234 (244) alignment 
Range on Protein: 1764-1905
Range on HMM: 92-234/244.0
LKPENAVRNRYRDILPYDDTRVKLD--SSNNDYINANHLSfeSNGTTFSYIASQ------AKHFWQMVWEQQVRLICMLTTLVEggrtkCHQYWPSAPGD
..|.|. .||    ||.|  || |   |  | ||||  .     | |  || .|      .  ||.|. |. | .. .| .. |       .||| .   
fnpnnswknregaglpfdfnrvplskgsmgntyinasfvg..clgrtaeyiltqhpladtsmdfwkmmlerhvnvlvvlgsvee.....edeywpdsepl

TCQFGDFSIVLNKEAARKGYILRDITVQRANAKGKRRLFQLQFTAWPDHG
     | .. |      |     .. ..    . .. |  .| . ||  |
ewyeeditvtltdrdefknikasnleiesdmneshqaltmfqisnwpsdg
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 1759-1805 5.9e-06 19.9 In-house 38-89 (440) alignment 
Range on Protein: 1759-1805
Range on HMM: 38-89/440.0
DCSLALKPENAVRNRYRDILPYDDTRVKLDS----SNNDYINANHLS-FESN
 .  |  |.| |.||||.|| || .|| |.      ..||||| ...  || 
psdiaslpnnkvknryrnilaydhsrvmleevkgvpdsdyinasyingiesr
0038934 (Phosphotyrosine protein) phosphatases II 1900-1987 7.5e-06 21.2 In-house 86-166 (194) alignment 
Range on Protein: 1900-1987
Range on HMM: 86-166/194.0
AWPDHGLPTSSAEMLTLVKEINNLKSRLvKPMPLLVHCSAGIGRTGVYILLELCLHqlqekaKEVNIPAILSQLREQRMNLVQTQDQY
 .||.| . | . .|. .. ..   ..  ..   .||| ||.||||. .   |  .         .  . .  .|| | . ...||..
pfpddgtvPsleillrfldlvdeflned.pggvvaVHCkaGlgRtGtlvaaYLiyr......lgmsaeeAialfrekRpgaipnqdyl