Gene PTPN6 in Monosiga brevicollis

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily PTPN6
Protein sequence
ID Type Fasta BLAST phosphatome Note
MbreP068_AA protein Get Run
MbreP068_AA_224-493 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_PTPN6_pd Subfamily PTPN6 206-496 7.5e-117 384.7 In-house 2-286 (306) alignment
Range on Protein: 206-496
Range on HMM: 2-286/306.0
TRLNLASIDGRFIELSKarseTEEEFGKAGFNEEFEQLQTMEHQHKFDRMEGARIENKSKNRYKNILPYDHTRVKLRnvPDGVIGADYINANFINGEAPG
|.|. ..|. |  ||.|    .||...||||.||||.||..|......|.|||..|||.|||||||||.|||||.|.   ..|.|.||||||.|..|..|
tsllakeieqrvselek....eeeslekagfeeefeelqqeeakkllsrkegakpenkeknryknilPfDhtrvilk..epsvpgsdyinanyikkevkg

TDKAYIASQGTMPDTVADFWQMIVEQNCRLVVMATNPVEKGKHKCTPYWPSSERRPArFGNYVVELLTEDNFDAYTVRRMSVA--VGEGDPREIYQYHYT
.||.|||.||....||.|||.|....|.|..||.|. ||.||.||..|||..|.... .|.. |. ..|.. ..|..|..||.    ... ||..|||..
sdksyiatqgclettvsdFWrmvwqensrvivmttkevErgkekCarYWPdeeekee.yGkisvtnvseksladYilRelsvskkkkkkeerevfqyhfk

SWPDHGVPPERE-FLQLIMKIRQHRDRLRKSipGLGPTLVHCSAGIGRTGTFLVIDIVLDLIRHYGIDCDIDIQSIIHKLRGQRSGMIQTAVCY
|||||||| ... .|............|...    ||..|||||||||||||.||||.|.||.. |.|.|||||......| ||||..||. .|
sWPdhgvpkdpgavLdfledvnrkqeeleea..eagpivvhCsaGiGRtGtfiviDillkliekkgldadidiqklvksvreqrsglvqteqqy

subfamily_PTPRD_pd Subfamily PTPRD 232-494 1.1e-89 296.6 In-house 21-268 (564) alignment
Range on Protein: 232-494
Range on HMM: 21-268/564.0
GKAGFNEEFEQLQTMeHQHKFDRMEGARieNKSKNRYKNILPYDHTRVKLRNVPdGVIGADYINANFINGEApgTDKAYIASQGTMPDTVADFWQMIVEQ
... |.||......  .|....  .     ||.||||.||..|||.||.|..|. |. | |||||.||.|    ..|||||.|| ...|..|||.|. ||
sdlkfeeeykkieeg.qqftweaankpa..NkaKNRyanivaYdhsRVvLskve.gdegsDYINAsfidgyr..krkayIAtqgPlaetiedFWRmvweq

NCRLVVMATNPVEKGKHKCTPYWPSSeRrPARFGNYVVELLTEDNFDAYTVRRMSV-AVGEGDPREIYQYHYTSWPDHGVPPE-REFLQLIMKIRQHRDr
|.. .|| |. .||||.||  |||.. . ....|...|.|  | ..  |..| ...    . . ||. |.|.||||||||| . ...|.||.|.|...  
nsstiVmltkleEkgkvkchkYWPek.g.tetygeltVtleeeeeladyeirtfklkkkkssesreVrqFhFtsWPdhgvpesatslLdlirkvralne.

lrksiPGLGPTLVHCSAGIGRTGTFLVIDIVLDLIRHygiDCDIDIQSIIHKLRGQRSGMIQTAV
     |. ||..||||||.||||||.|||..|. |..   . ..|| .....|| ||  |.||  
.....pdagPivVhCSaGVGRTGtfividamlerike...ektvDiyqyvkalrkqRnamVqtee

0050432 (Phosphotyrosine protein) phosphatases II 226-494 2.9e-88 291.5 In-house 34-286 (308) alignment
Range on Protein: 226-494
Range on HMM: 34-286/308.0
ETEEEFGKAGFNEEFEQLQTMEHqhKFDRMEGARIENKSKNRYKNILPYDHTRVKLrnvpDgvIGADYINANFINGEAPGTDKAYIASQGTMPDTVADFW
  |. ... ...||||.|. .     ...  ... |||.|||||.||||||.||||    |   | |||||....|   . ....|| || .|.||.|||
llekaldlglleeefeellsvkp..lleysvallpenkdkNrykdilpydhsRVkl....d..egsdYInAsyvdgyssklprkfIatqgPlpntvedFw

QMIVEQNCRLVVMATNPVEKGKHKCTPYWPSSER-RPARFGNYVVELLTEDNFDAYTVRRMSVAV-GEGDPREIYQYHYTSWPDHGVPPE-REFLQLIMK
.|. |||.|..|| |..||.|. || .|||...   . ..|...|.|| |...| |||| . .   |.|. |.....|||.||||||||. ...|... .
rmvweqnvrvIvmLtklvengrekcaqYwplelgggsleygkftvtllseevlddytvrtleltnlgdgesrtvthfhytnWpdhgvPpspeilldflel

IRQHRdrlRKsipglGPTLVHCSAGIGRTGTFLVIDIVLDLIRHYgidCDIDIQSIIHKLRGQRSGMIQTAV
.|...   ..     ||..||||||.||||||...|..|.....    . .|......||| || ||.||  
vrksl...pg.....gpivVHCsaGvGRtGtfialdllleqleke...ggvdvfeavkklReqRpgmvqtpe

0046845 (Phosphotyrosine protein) phosphatases II 235-494 3.4e-88 291.0 In-house 1-261 (284) alignment
Range on Protein: 235-494
Range on HMM: 1-261/284.0
GFNEEFEQLQTMEHQHKFDRMEGARIENKSKNRYKNILPYDHTRVKLRNVPDGVIGADYINANFINGEAP---GTDKAYIASQGTMPDTVADFWQMIVEQ
|. ||||.|. . . . ...  ... ||.||||||.||||||.||||....... . |||||....|       . |..|| || .|.||.|||.|. ||
gleeefeellsltvklllslsvallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweq

NCRLVVMATNPVEKGKHKCTPYWPSSeRRPARFGNYVVELLTEDNFDAYTVRRMSVAVG--EGDPREIYQYHYTSWPDHGVPP-EREFLQLIMKIRQHRD
|.|..|| |..||.|. || .|||..   . ..|.. |.|| |...| ||||....     .| .|.....||||||||||||  . .|... ..|....
nvrvIVmltelvengrekcaqYwple.gevltygdftvtllseevkddytvrtleltnlgytgesrtvthfhytswpdhgvppspedlleflrlvrelle

RlrksIPGLGPTLVHCSAGIGRTGTFLVIDIVLDLIRHYGIDCDIDIQSIIHKLRGQRSGMIQTAV
.    .|| ||..||||||.||||||...|..|..... |... .|.......|| || ||.||  
n....lpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtle

0051299 (Phosphotyrosine protein) phosphatases II 231-493 5.3e-85 280.6 In-house 20-272 (288) alignment
Range on Protein: 231-493
Range on HMM: 20-272/288.0
FGKAGFNEEFEQLQTMEHQhkFDRMEGARIENKSKNRYKNILPYDHTRVKLRNVPDgVIGADYINANFINGeaPGTDKAYIASQGTMPDTVADFWQMIVE
 |..|. ||||.|. . ..  ...  ... ||..||||..||||||.||||..... | | |||||..|.|  . .....|| || .|.||.|||.|. |
ngltglleefeellsllpd..ltlsaallpenleknRysdilpydhsRVkLsvldg.vegsdYinAsyidg..ynlkrkfIatqgPlpntvedFWrmvwe

QNCRLVVMATNPVEKGKHKCTPYWPSseRRPARFGNYVVELLTEDNFDAYTVRRMSVAV-----GEGDPREIYQYHYTSWPDHGVPP-EREFLQLIMKIR
||.|..|| |..||.|. || .|||.  . .  .|...|.|| |. .| |||| . |       |.| .|.....|||.|||||||.  ...|......|
qnvrvIvmltklvelgrekcaqYwpl..ggsltygditvtllseevlddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpdspellldflrlvr

QHRDrlrksiPGLGPTLVHCSAGIGRTGTFLVIDIVLDLIRHYgidCDIDIQSIIHKLRGQRSGMIQTA
...       .| ||..||||||.||||||...|..|.....      .|. .....|| || ||.|| 
kala......sgggpvvVHCsaGvgRtgtfialdllleqleke...ggvdvleavkrlreqRpgmvqtp

0036941 (Phosphotyrosine protein) phosphatases II 229-493 1e-83 276.4 In-house 8-263 (297) alignment
Range on Protein: 229-493
Range on HMM: 8-263/297.0
EEFGKAGFNEEFEQLqtMEHQHKFDRMEGARIENKSKNRYKNILPYDHTRVKLrnvpDGvIGADYINANFIngEAPGTDKAYIASQGTMPDTVADFWQMI
. ...|.. .|||.|  ..... ...  ... ||..|||||.|||||||||||    |.  | |||||...  . .. ....|| || .|.||.|||.|.
kllflalllkefeel..lpllllgslsvallpenleknRykdilpydhtRVkl....dd.egsdYinAsyv..dgydlkrkfIatqgPlpntvedFWrmv

VEQNCRLVVMATNPVEKGKHKCTPYWPSSERRPARFGNYVVELLTEDN--FDAYTVRRMSVAV-GEGDPREIYQYHYTSWPDHGVPP-EREFLQLIMKIR
 |||.. .|| |..||.|. || .|||. |. .  .|...|.||...   .| ||.| . |   |.|..|.....|||.|||||||.  ...|..| ..|
weqnvtvIvmltelvelgrekcaqywpleegesltygdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfielvr

QHRDRLRKSipglGPTLVHCSAGIGRTGTFLVIDIVLDLIRHYGIDCDIDIQSIIHKLRGQRSGMIQTA
.... |...    ||.|||||||.||.|||...|..|...... . . .|| ....||| || |..|| 
kvlkllpsg....gpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtl

0045450 (Phosphotyrosine protein) phosphatases II 232-493 1.2e-83 276.7 In-house 25-290 (307) alignment
Range on Protein: 232-493
Range on HMM: 25-290/307.0
GKAGFNEEFEQLQTMEHQHKFDRMEGARIENKSKNRYKNILPYDHTRVKLRNVPDGVIGADYINANFING------EAPGTDKAYIASQGTMPDTVADFW
...|. .|||.|. ..... ... .... |||.|||||.||||||||||| .... . . |||||....       . .  ....|| || .|.||.|||
fltgllkefekllsvtvfllgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydlkrkfIatqgPlpetvedFw

QMIVEQNCRLVVMATNPVEKGKHKCTPYWPSSeRRPARFGNYVVELLTEDNFDAYTVRRMSVAV--GEGDPREIYQYHYTSWPDHGVPPE-REFLQLIMK
.|. ||.....|| |..||.|. || .|||.. . .  .||..|.|| |.  | ||||.. |    |.| .|.....|||.||||||||   |.|..| .
rmlweqgvtvivmltelvelgrekcaqywPde.geeltygnftvtllseehldgytvrtlevtdldgtgesrtvthfhytgwpdhgvppsfeelldfiee

IRQHRDRLRKSipglGPTLVHCSAGIGRTGTFLVIDIVLDLIRHYGIDCDIDIQSIIHKLRGQRSGMIQTA
.|.....|.|.    ||.|||||||.||||||......|..... |. .|.|.......|| ||.|..|. 
vrkaleelpkg....gpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnp

0047943 (Phosphotyrosine protein) phosphatases II 228-494 5.3e-83 273.9 In-house 6-259 (273) alignment
Range on Protein: 228-494
Range on HMM: 6-259/273.0
EEEFGKAGFNEEFEQLQTMEHqhKFDRMEGARIENKSKNRYKNILPYDHTRVKLrnvpdGVIGADYINANFINGeaPGTDKAYIASQGTMPDTVADFWQM
|. .|.... ||||.|. . .   ...  ....|||.|||||.||||||.||||     |  | |||||....|  . . ...|| || .|.||.|||.|
ekllgltllleefelllslkp..lltysvallpenkdknrykdilpydhsrvkl.....gdggsdyinAsyvdg..ynlkrkfiatqgPlpntvedfwrm

IVEQNCRLVVMATNPVEKGKHKCTPYWPSSERR-PARFGNYVVELLTEDNFDAYTVRRMSVAV-GEGDPREIYQYHYTSWPDHGVP-PEREFLQLIMKIR
. |||.|..|| |..||.|. || .|||...   . ..|.. |.|| |...| |||| . .   | |..|.....|||.|||||||    ..|..|...|
vweqnvrviVmLtelvelgrekcaqYwpleggelsltygkftvtllseetkddytvrtleltnlgtgesrtvthfhytgwpdhgvppslesllefielvr

QHRDRLRKSipglGPTLVHCSAGIGRTGTFLVIDIVLDLIRHYGidcDIDIQSIIHKLRGQRSGMIQTAV
...  |...    ||..||||||.||||||...|..||.....|    .|. .....|| || ||.||  
kalealpsn....gpvvVHCsaGvgRtgtfialdllldqlekeg...gvdvleavkllrsqRpgmvqtpe

0039614 (Phosphotyrosine protein) phosphatases II 230-493 5.1e-82 270.9 In-house 28-275 (297) alignment
Range on Protein: 230-493
Range on HMM: 28-275/297.0
EFGKAGFNEEFEQLQTMEHqhkfDRMEGARIENKSKNRYKNILPYDHTRVKLRNVPDGVIGADYINANFINGeaPGT-DKAYIASQGTMPDTVADFWQMI
 ..| .. .|||.|. . .    |. .....|||.|||||.||||||.||||  ... . . |||||....|  .   ....||.|| .|.||.|||.|.
ansktllllefeellslkp....dysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdg..ydlltrkfIatqgPlpetvedFwrmv

VEQNCRLVVMATNPVEKGKhKCTPYWPSSERrpaRFGNYVVELLTEDNFDAYTVRRMSVAVgEGDPREIYQYHYTSWPDHGVPP-EREFLQLIMKIRQHR
 ||... .|| |..||.|. || .|||...    ..|...|.||...  | |||| ..|   .| .|......||.||||||||  . .|... ..|...
weqgvtvivmLtklvelgr.kcaqywpeegg...tygdftvtllkvehldgytvrtlevtn.ngesrtvthfqytgwpdhgvppslellleflelvreal

DRLrksiPGLGPTLVHCSAGIGRTGTFLVIDIVLDLIRHYgidCDIDIQSIIHKLRGQRSGMIQTA
 .|    |. ||.|||||||.||||||......|......   ...|.......|| ||.|..|| 
ael....pkggpvlVHCsaGvgRtGtfiaaylmleqleke...ggvdvleavkelreqRpgavqtp

DSPc_SM00195 236-494 6.9e-82 270.1 In-house 2-249 (263) alignment
Range on Protein: 236-494
Range on HMM: 2-249/263.0
FNEEFEQLQTMEHQHkfDRMEGARIENKSKNRYKNILPYDHTRVKLRNVPDGvIGADYINANFINGEapGTDKAYIASQGTMPDTVADFWQMIVEQNCRL
..||||.|.......  .  |... .|||||||||||||||||||| . ..   | ||||||.|.|.    .|.||| || .|.||.|||.|..|.....
lkeefekleestspk..etteaekkknksknRyknilpydhtrVklkkeekk.egsdYINAnyikga..nkkkkyIatQgPlpstvedFWrmvweekvki

VVMATNPVEKGKHKCTPYWPSSERRPARFGNYVVELLTEDNFD-AYTVRRMSVAVGEG-DPREIYQYHYTSWPDHGVP-PEREFLQLIMKIRQHRDRLrk
.|| |...|.|| ||. |||... .. .||.. |.|  ... .  ...| ...   .  ..|...||.|..|||||||  ....|.|. ........   
ivmlteeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkksksts..

sipgLGPTLVHCSAGIGRTGTFLVIDIVLDLIRHYGIdcdIDIQSIIHKLRGQRSGMIQTAV
     ||..||||||.||||||..|||.|. ....     .||..|. .|| || ||.||  
....sgpivVhCsaGvgRtgtfvtidiilskleeekk...vdifeivkelRkqRpgmvqtle

PTPc_SM00194 236-494 6.9e-82 270.1 In-house 2-249 (263) alignment
Range on Protein: 236-494
Range on HMM: 2-249/263.0
FNEEFEQLQTMEHQHkfDRMEGARIENKSKNRYKNILPYDHTRVKLRNVPDGvIGADYINANFINGEapGTDKAYIASQGTMPDTVADFWQMIVEQNCRL
..||||.|.......  .  |... .|||||||||||||||||||| . ..   | ||||||.|.|.    .|.||| || .|.||.|||.|..|.....
lkeefekleestspk..etteaekkknksknRyknilpydhtrVklkkeekk.egsdYINAnyikga..nkkkkyIatQgPlpstvedFWrmvweekvki

VVMATNPVEKGKHKCTPYWPSSERRPARFGNYVVELLTEDNFD-AYTVRRMSVAVGEG-DPREIYQYHYTSWPDHGVP-PEREFLQLIMKIRQHRDRLrk
.|| |...|.|| ||. |||... .. .||.. |.|  ... .  ...| ...   .  ..|...||.|..|||||||  ....|.|. ........   
ivmlteeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkksksts..

sipgLGPTLVHCSAGIGRTGTFLVIDIVLDLIRHYGIdcdIDIQSIIHKLRGQRSGMIQTAV
     ||..||||||.||||||..|||.|. ....     .||..|. .|| || ||.||  
....sgpivVhCsaGvgRtgtfvtidiilskleeekk...vdifeivkelRkqRpgmvqtle

0040438 (Phosphotyrosine protein) phosphatases II 232-493 1.1e-81 269.9 In-house 16-262 (317) alignment
Range on Protein: 232-493
Range on HMM: 16-262/317.0
GKAGFNEEFEQLQTMEHQhkfDRMEGARIENKSKNRYKNILPYDHTRVKLRNvPDGVIGADYINANFINGeaPGTDKAYIASQGTMPDTVADFWQMIVEQ
.. .. ||||.|... .    .. .... |||.||||..||||||.|||| . ..|. . |||||....|  |   ...|| || .|.||.|||.|. ||
dftalleefedllslkld...tysvaelpenkdknrypdilpydhsRVkLsp.lggdldsdYInAsyvdg..pnlkrkfIatqgPlpntvedFwrmvweq

NCRLVVMATNPVEKGKHKCTPYWPSseRRPARFGNYVVELLTEDNFDAYTVRRMSVAV-GEGDPREIYQYHYTSWPDHGVPP-EREFLQLIMKIRQHRDr
.....|| |...|.|. || .|||.  . .  .|...|.|| |.  . .|.|.. |   |....|.....|||.||||||||  ...|... ..|.... 
gvtvivmLteleelgrekcaqYwpl..getltygdftvtllseeelagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfleavreale.

lrksiPGLGPTLVHCSAGIGRTGTFLVIDIVLDLIRHYGidcDIDIQSIIHKLRGQRSGMIQTA
     .. ||.|||||||.||||||......|......|   ..|.......|| ||.|..|| 
.....dpggpvlVHCsaGvgRtGtfiaaylmleqlekeg...gvdveeavkelreqRpgavqtp

subfamily_PTPRB_pd Subfamily PTPRB 232-496 4.4e-79 260.5 In-house 23-274 (293) alignment
Range on Protein: 232-496
Range on HMM: 23-274/293.0
GKAGFNEEFEQLQTMEHQHKFDRMEgaRIENKSKNRYKNILPYDHTRVKLRNVPDgVIGADYINANFINGEApgTDKAYIASQGTMPDTVADFWQMIVEQ
 ...|.||.|.|........ .  |  . .|..||||.|||||||.|||| .. |   |.||||||.|.|    . . .||.|| .|.|| |||.|. |.
sdlrfseeyeelkavgkdqavkaae..lavnraknrytnilpydhsrvkLaalkd.esgsDYinanyipgyn..sprefiatqGPlpetvddfWrmvwek

NCRLVVMATNPVEKGKHKCTPYWPSSErRPARFGNYVVELLTEDNFDAYTVRRMSVAVgEGDPREIYQYHYTSWPDHGVPPERE-FLQLIMKIRQHrdrL
... .|| |. ||||| ||  |||. | .|  .|.  |.|..|.. . ...| ...   | . |.. |||.||||||||| . . .|... ..|..   .
kssiivmltqlvekgkvkCeeYWPade.epvlyGdikvtlvaeeeledwvirelkiek.ekeerkvrqyhftsWpdhgvPektktlldfvrtvrea...i

RKSiPGLGPTLVHCSAGIGRTGTFLVIDIVLDLIRHygiDCDIDIQSIIHKLRGQRSGMIQTAVCY
.|.    .|..||||||.||||||. .| .|. |..   .  .|| .|...|| .|  ..||   |
ekt.askrPivvhCsaGvGRtGtfialdrllqaiee...edyvdifgivaelReeRnllvqtekqY

0043336 (Phosphotyrosine protein) phosphatases II 231-494 7.2e-79 260.4 In-house 17-264 (278) alignment
Range on Protein: 231-494
Range on HMM: 17-264/278.0
FGKAGFNEEFEQLQTMEHqhkFDRMEGARIENKSKNRYKNILPYDHTRVKLrNVPDGVIGADYINANFINGeaPGTDKAYIASQGTMPDTVADFWQMIVE
 .|... .|||.|... .   ...  ....|||.|||||.||||||.|||| .. .|. . |||||....|  .   ...||.|| .|.||.|||.|. |
nlktllllefeellsfkl...dtysiallpenkdknrykdilpydhsrvkl.sllggdldsdYinAsyvdg..ynvprkfiatqgPlpetvedFwrmvwe

QNCRLVVMATNPVEKGKHKCTPYWPsseRRPARFGNYVVELLTEDNFDAYTVRRMSVAV-GEGDPREIYQYHYTSWPDHGVP-PEREFLQLIMKIRQHRD
.... .|| |..||.|. || .|||   . . ..|...|.|| |. .| |||| . |   |.| .|....|||..||||||| .   .|... ..|....
lgvttivmLtelvelgrvkcaqYwp...ggsltygdftvtllkeehlddytvrtlevtnlgdgesrtvthyhylgwpdhgvpeslsllldflkavreale

rlrksiPGLGPTLVHCSAGIGRTGTFLVIDIVLDLIRHYGidcDIDIQSIIHKLRGQRSGMIQTAV
      .  ||.|||||||.||||||......|......|    .|.......|| || |..||  
......dsngpvlVHCsaGvgRTGtfialyllleqlekeg...gvdleeavkelreqRpgavqtps

subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 230-494 1.2e-78 259.4 In-house 16-267 (318) alignment
Range on Protein: 230-494
Range on HMM: 16-267/318.0
EFGKAGFNEEFEQLQTM-EHQHKFDRmegARIENKSKNRYKNILPYDHTRVKLRNVPdGVIGADYINANFINGEApgTDKAYIASQGTMPDTVADFWQMI
| |.  ..||.|.|.   |.  ...        || |||| |||.||||||||...  |. |.||||||.|.|     .|||||.|. .|.|. |||.|.
esGelllseeyerlsrseetvtslks...lepvnkaknryanilaydhtrvkLqmle.geegsDyinanyidGyr..rkkayiaaqaPlpetieDfWrmv

VEQNCRLVVMATNPVEKGKHKCTPYWPSSErrPARFGNYVVELLTEDNFDAYTVRRMSVAV-GEGDPREIYQYHYTSWPDHGVPPERefLQLIMKIRQHR
 |||....|| |. .|.||.|.  ||||..  .  .|. ||||  | ... |..|...|   .| . |.. |||||||||.||| .    .|.  .|| .
WeqnsavivmltqeeergkakvhryWPskg..srsygklvvelkeevelsdyvlrefkvtrteeeesrqvrqyhytsWpdegvpesg..aslldlvrqvs

DRlrKSIPGLGPTLVHCSAGIGRTGTFLVIDIVLDLIRHYGIdcdIDIQSIIHKLRGQRSGMIQTAV
    .  .| ||..||||||.||||.|...||.|. |.. ..   .|.  ....|| ||  |.||  
ka..qqksgagpivvhCsaGvGrtGvfiavdillerikaeal...vDvfqtvkqlreqrnlmvqted

subfamily_PTPN12_pd Subfamily PTPN12 229-493 4e-78 257.2 In-house 3-263 (290) alignment
Range on Protein: 229-493
Range on HMM: 3-263/290.0
EEFGKAGFNEEFEQLQTMEHQHKFDR----MEGARIENKSKNRYKNILPYDHTRVKLRNVpDGVIGADYINANFINGeaPGTDKAYIASQGTMPDTVADF
|. |.. |..||..|.......| ..     .| . ||. |||||.|||||..||.|..  ... | ||||||||.|  .  ...|||.|| .|.|. ||
ekegeeefakefqklkklsekykaekvysteagekeenvkknrykDilPydksrvelski.eeeegsdYinanfikg..vegkleyiaaqgPLpktlddf

WQMIVEQNCRLVVMATNPVEKGKHKCTPYWPSSERRPARFGNYVVELLTEDNFD-AYTVRRMSVAVGeGDPREIYQYHYTSWPDHGVPPE-REFLQLIMK
|.|| |.| ..|||| . || ||.||  |||..  .. .||.. |.| .|...|  ...| . | .  .. |..||.|||.|||||||    . |.|| .
WrmiweknveivvmaCrevelgkkkCerYWpeegeeelefgefevtleeekavdddflirtLkveaq.kesrkvyqfhYtaWPDhgvPssakslleliel

IRQHRDrlRKSIpglgPTLVHCSAGIGRTGTFLVIDIVLDLIRHYGIDCDIDIQSIIHKLRGQRSGMIQTA
.|....  ....    | .||||||.||||| ..||.| .|...  |. ..|. ... .|| ||. ..|| 
vrelqe..seda....PlvvhCsaGvGrtGtiiaidyvrellkaekipeeldvfdlvlelrkqraalvqtk

subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 228-496 3.1e-76 251.2 In-house 15-268 (288) alignment
Range on Protein: 228-496
Range on HMM: 15-268/288.0
EEEFGKAGFNEEFEQLQTMEHQHKFDrmEGARIENKSKNRYKNILPYDHTRVKLRNVPDgVIGADYINANFINGEapGTDKAYIASQGTMPDTVADFWQM
 .  ...||.||...| ..|.... .   | . .|..||||.||||||..||||..... . |||||||..|.||  . .|.|||.|| ..||| |||..
ksarnrtgfseeynsLaalektksvt..agrlavnakknRyrnilpyDekrvklkklee.eagaDYinasyidge..kkkkkyiatqgPladtvndfWel

IVEQNCRLVVMATNPVEKGKHKCTPYWPSSERrPARFGNYVVELLTEDNFDAYTVRRMSVAvGEGDPREIYQYHYTSWPDHGVPPE-REFLQLIMKIRQH
. |..   .|| |. ||.||.||  |||.... | ..|.  |.|. . . . ...|.. .   ... .|| ||.|..|||||||   ...|.|. .. . 
vyenktstivmltelveggktkCeeYWPdadk.pknyGsvtvtlveskeledfvlrkllle.kkkteleitqyqylaWpdhgvPeskapllellrqvkva

RDRLrksipgLGPTLVHCSAGIGRTGTFLVIDIVLDLIRHygiDCDIDIQSIIHKLRGQRSGMIQTAVCY
 .        .|| .||||||.||||||...| ..| ...   .  ||. ....||| ||  ..||   |
nqad......tgpiivhCsaGvGrtgtFialdalidavee...edyiDvagtvaklRkqRallvqtlkqY

0045098 (Phosphotyrosine protein) phosphatases II 255-493 9.9e-75 246.8 In-house 26-258 (278) alignment
Range on Protein: 255-493
Range on HMM: 26-258/278.0
MEGARIENKSKNRYKNILPYDHTRVKlrnvpdgvigaDYINANFINGEapgtDKAYIASQGTMPDTVADFWQMIVEQNCRLVVMATNPVEKGKHKCTPYW
 .. ...|..|||||.||||||.|||           |||||..|.|     .|..|| || .|.||||||.|. |.... .||.|. ||.|. || .||
tpalylgnldknRykdilpydhsrVk...........dYINAsyidgy....pkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrekcaqyw

PSseRRPARFGNYVVELLTEDNFDAYTVRRMSVAV-----GEGDPREIYQYHYTSWPDHGVPPER---EFLQLIMKIRQHRDRLRKSI-------PGLGP
|.  . . ..|...|.|| |...| ||.|.. |        .. .|.....||..|||||||..     ||.|.  ||.....| . .       .. ||
pe..ggsltygdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsggp

TLVHCSAGIGRTGTFLVIDIVLDLIrhygiDCDIDIQSIIHKLRGQRSG-MIQTA
.|||||||.|||||. .....|.|.     .. .|.......|| || | ..|. 
vlVHCsaGvgRtGtlvaaylmlell.....eggvdlleavkelrsqRpglavqnl

0042113 (Phosphotyrosine protein) phosphatases II 258-493 4.8e-72 237.6 In-house 5-229 (245) alignment
Range on Protein: 258-493
Range on HMM: 5-229/245.0
ARIENKSKNRYKNILPYDHTRVKLRnVPDGVIGADYINANFINGeaPGTDKAYIASQGTMPDTVADFWQMIVEQNCRLVVMATNPVEKGKHKCTPYWPSs
...|||.||||..|||||||||||  ...|  . |||||....|  .   . .||.|| .|.||.|||.|. |.... .|| |...|.|..|| .|||. 
llpenkdknrysdilpydhtrvkls.pdggdldsdyinasyvdg..yritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywpl.

eRRPARFGNYVVELLTEDNFDAYTVRRMSVAV-GEGDPREIYQYHYTSWPDHGVPP-EREFLQLIMKIRQHRDRlrksiPGLGPTLVHCSAGIGRTGTFL
 . . ..|...|.||.|...| |||| ..|   |.. .||...|||..|||||||.  . .|...  .|... .     .. ||.|||||||.||||||.
.gesltygdftvtllseehlddytvrtlevtnlgddesrevihyhylpwpdhgvpdllellldflefvrkalae.....dsngpvlVHCsaGvgRtGtfi

VIDIVLDLIRHYgidCDIDIQSIIHKLRGQRSGMIQTA
.....|......   ...........|| ||.|..|| 
aaylmleqleke...lgvsleeavkelrsqRpgavqtp

0040439 (Phosphotyrosine protein) phosphatases II 255-493 5.2e-72 237.7 In-house 4-232 (249) alignment
Range on Protein: 255-493
Range on HMM: 4-232/249.0
MEGARIENKSKNRYKNILPYDHTRVKLRNVPDgVIGADYINANFINGeaPGTDKAYIASQGTMPDTVADFWQMIVEQNCRLVVMATNPVEKGKHKCTPYW
 .. . |||.||||..||||||.||||  .|. . . |||||..|.|  .   ...|| || .|.||.|||.|. |.... .||.|..||.|. || .||
svallpenkdknrypdilpydhsrvklsilpg.lflsdyinAsyidg..yyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqyw

PSseRRPARFGNYVVELLTEDNFDAYTVRRMSVAV-GEGDPREIYQYHYTSWPDHGVP-PEREFLQLIMKIRQHRDRLrksiPGLGPTLVHCSAGIGRTG
|.  . .  .|...|.|| .. .| |||| . .   ..|..|......||.|||||||    ..|..| ..|.....|    |  ||.|||||||.||||
pl..ggsleygdftvtllsvevkddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleel....pkggpvlVHCsaGvgRtG

TFLVIDIVLDLIRHYgidCDIDIQSIIHKLRGQRSGMIQTA
||......|......   ...|.......|| ||.|..|. 
tfiaaylmleqleke...lgvdleeavkllrsqRpgavqnp

Y_phosphatase Protein-tyrosine phosphatase 262-494 1.9e-71 235.5 Pfam-A 1-224 (235) alignment
Range on Protein: 262-494
Range on HMM: 1-224/235.0
NKSKNRYKNILPYDHTRVKLrnvpDGVIG-ADYINANFINGEApGtDKAYIASQGTMPDTVADFWQMIVEQNCRLVVMATNPVEKGKHKCTPYWPSSERR
||.|||||.|||||.|||||    .|  |  ||||||...|     .|..||.|| ...|..|||.|.........|| |. .|||. || .|||..|..
nkkknRykdilpydktrvkl....kgsegpsdYInAnyvkgyk.e.kkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeee

PARFGNYVVELL-TED-NFDAYTVRRMSVAVGEGD--PREIYQYHYTSWPDHGVPP-EREFLQLIMKIRQHRdrlrksIPGLGPTLVHCSAGIGRTGTFL
. ..|.. |||   |  . ..||.| ...   ...  .||..|.|||.|||||||   ...|.|| |.....       .  ||..||||||.||||||.
sltygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkveksk......eaksgpvvVhCsaGvgRtgtfv

VIDIVLDLIRHYGIdcdIDIQSIIHKLRGQRSGMIQTAV
..||.|. ... .    .|. .|. .|| || ||.|.. 
aldilleqleaeee...vdvlqivkelRkqRpgmvqsle

Y_phosphatase Protein-tyrosine phosphatase 262-494 1.9e-71 235.5 In-house 1-224 (235) alignment
Range on Protein: 262-494
Range on HMM: 1-224/235.0
NKSKNRYKNILPYDHTRVKLrnvpDGVIG-ADYINANFINGEApGtDKAYIASQGTMPDTVADFWQMIVEQNCRLVVMATNPVEKGKHKCTPYWPSSERR
||.|||||.|||||.|||||    .|  |  ||||||...|     .|..||.|| ...|..|||.|.........|| |. .|||. || .|||..|..
nkkknRykdilpydktrvkl....kgsegpsdYInAnyvkgyk.e.kkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeee

PARFGNYVVELL-TED-NFDAYTVRRMSVAVGEGD--PREIYQYHYTSWPDHGVPP-EREFLQLIMKIRQHRdrlrksIPGLGPTLVHCSAGIGRTGTFL
. ..|.. |||   |  . ..||.| ...   ...  .||..|.|||.|||||||   ...|.|| |.....       .  ||..||||||.||||||.
sltygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkveksk......eaksgpvvVhCsaGvgRtgtfv

VIDIVLDLIRHYGIdcdIDIQSIIHKLRGQRSGMIQTAV
..||.|. ... .    .|. .|. .|| || ||.|.. 
aldilleqleaeee...vdvlqivkelRkqRpgmvqsle

subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 224-494 2.7e-70 232.0 In-house 13-270 (319) alignment
Range on Protein: 224-494
Range on HMM: 13-270/319.0
RSETEEEFGKAGFNEEFEQLQTMEHQhkfDRMEGARIENKSKNRYKNILPYDHTRVKLRNVPDgVIGADYINANFINGEApgTDKAYIASQGTMPDTVAD
| .. .. |. ....||..|.. . .   .  .  . |||.||||.|||.||.|||.| .... | |.|||||.||.|      ...|| |. . .|. |
rlkalastgetllekefkllkeavnd...tfdsaskeenkkknryqnilaydrtrvvlseldg.vegsdyinasfidgyq..erekfiatqaPlentied

FWQMIVEQNCRLVVMATNPVEKGKHKCTPYWPSSErrPARFGNYVVELLTEDNFDAYTVRRMSVAVGEGDP--REIYQYHYTSWPDHGVPPER-EFLQLI
||.|. |...  ||| |. |||.| |.  |||. .  . ..|...|.|. |.. . | .|....    ..   ||. ...||.||||.|| .    |.|.
fWrmvWeeessivvmltklveklkvklkkywpeen..feeyGrlivtleeeeeledyiirklklnkkssevetRevkhfqyteWpdhdvPekatslldll

MKIRQHRDRlrksiPGLGPTLVHCSAGIGRTGTFLVIDIVLDLIRHYGIdcdIDIQSIIHKLRGQRSGMIQTAV
 .||. |..     .  ||  ||||||.||||||.|.|..|. ... |.   .|. |.. .|| ||  |.|.  
krirksrek.....tqsgPivvhCsaGvGRtGtfivldamlervkeegv...lDvfstvsrlRtqRnimvqrpe

subfamily_PTPN13_pd Subfamily PTPN13 236-493 1.1e-69 229.7 In-house 13-255 (273) alignment
Range on Protein: 236-493
Range on HMM: 13-255/273.0
FNEEFEQLQTMEHQHKFDrmEGARIENKSKNRYKNILPYDHTRVKLRNVPDgvigadYINANFINGEAPGTDKAYIASQGTMPDTVADFWQMIVEQNCRL
 .|||..|. .  . . .  .| . |||.||||.|.||||.||||| .         ||||..|. .       |||.|| .|.||.|||||. ||....
Paeefkelrelkpldtce..vgkkkenkdknryrnvlPydetrvklgdegg......yinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweqkaev

VVMATNPVEKGKHKCTPYWPSSERRPARFGN-YVVELLTEDNFDAYTVRRMSVAV-GEGDPREIYQYHYTSWPDHGVPPE-REFLQLIMKIRQHRDrlrk
..| |. .|||| ||  |||.|....    | . ||||   . |...||.. |     |. ||. . ....||||||| .  |.||.....|. ..    
iamvtlekekgkvkchrywPesknkklkvsnrlevellkvqkldgfvvralavkdsesgesrevahlnfvkwPdhgvPssaaellqfvaevrrlqt....

sipGLGPTLVHCSAGIGRTGTFLVIDIVLDLIRHygiDCDIDIQSIIHKLRGQRSGMIQTA
     || .|||||||||.||...||.||.|| .   | ..|.. |..||| || |..|| 
...dagPivvhcsaGiGrsGtlitidvvlglier...dkefdvkeivrklreqrqgvvqtk

0037934 (Phosphotyrosine protein) phosphatases II 258-493 1.9e-69 229.2 In-house 6-228 (243) alignment
Range on Protein: 258-493
Range on HMM: 6-228/243.0
ARIENKSKNRYKNILPYDHTRVKLrnvpDGvigADYINANFINGEapgtDKaYIASQGTMPDTVAD----FWQMIVEQNCRLVVMATNPVEKGKHKCTPY
 ..||.|||||..||||||.||||    .|    ||||||.|..     .. .||.|| .|.||.|    ||.|. |.... .|| |..||.|. || .|
llpenlsknrysdilpydhsrvkl....eg...sdyinanliyvt....pr.liatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqy

WPsseR-RpaRFGNYVVELLTEDNFDAYTVRRMSVAV--GEGDPREIYQYHYTSWPDHGVPP-EREFLQLIMKIRQHRDRL-------RKsipglGPTLV
||        ..|...|.|| | ..| |||| ...     .. .|....|||..|||||||.    .|... ..|.. ..|       ..     ||.||
wp...gev..tygdftvtllseehlddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsg.....gpvlV

HCSAGIGRTGTFLVIDIVLDLIrhygidcDIDIQSIIHKLRGQRSG-MIQTA
|||||.|||||.......|.|.       ..|.......|| ||.| ..|| 
HCsaGvgRtGtliaaylmllll.......gvdleeavkllreqRpgkavqtp

subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 228-496 3.3e-69 228.1 In-house 9-265 (281) alignment
Range on Protein: 228-496
Range on HMM: 9-265/281.0
EEEFGKAGFNEEFEQLQTMEHQHKFDrmEGARIENKSKNRYKNILPYDHTRVKLRNVPDGvIGADYINANFINGEApgTDKAYIASQGTMPDTVADFWQM
...  .||| ||.|.|. .. ..        . ||. ||||.||  ||.||||. .  .    .|||||||..|     .|.|||.|| .|.....||||
lsqndnaGfieeyeklaaigvdntat..askadenvlknrYsnivaYDatrvkvtpneen.kntDYinanfvpgyk..gekeyiatqgPvPaslvafWqm

IVEQNCRLVVMATNPVEKGKHKCTPYWPsSERRPARFGNYVVELLTEDNFDAYTVRRMSVAVGEGDPREIYQYHYTSWPDHGVPPE-REFLQLIMKIRQH
..||. ...|| |. .|.|| ||  |||  ..   ..|...|. ..| .   |  |....   .|..||. | .||.||||||| . .|.|.   .... 
vweqkvsaivmvtreieagklkChrYWP.ddnselkygdvtvkstaeeekatyierkfkleresgetreveqlaytaWPdhGvPattkellefrkevlkl

RDRLRKsipglGPTLVHCSAGIGRTGTFLVIDIVLDLIRHYGidCDIDIQSIIHKLRGQRSGMIQTAVCY
... .|      | ..|||||.|||||.. .| ... . .     ..|.. ....|| .|  |.|| |.|
tekktk.....aplvihCsaGvGrtGtyialDrlvkaveael..eeldvkavvaelrkernlmvqtvvqy

subfamily_PTPRG_pd Subfamily PTPRG 232-493 1.6e-67 223.0 In-house 17-273 (563) alignment
Range on Protein: 232-493
Range on HMM: 17-273/563.0
GKAGFNEEFEQLQTMEHQHKFDRMEGARIENKSKNRYKNILPYDHTRVKLRNVPDGVIGADYINANFINGEApgTDKAYIASQGTMPDTVADFWQMIVEQ
|. ||.||||.||.   ....|     . ||| |||| ||..||..||||...|.     ||||||.|.|      ||.||.|| ..||. |||.|| ||
gdigfseefealqsetiskdldaehsqkpenkrKnRylnivaydrsRvklsplpgkkkklDYinAnyidGyq..kskafiatqgplkdtfddFWrmiWeq

NCRLVVMATNPVEKGKHKCTPYWPSseRRPARFGNYVVELLTEDNFDAYTVRRMSVAV---GEG----DPREIYQYHYTSWPDHGVPPEREFlQLIMKIR
|  ..|| || ||.|..||  |||.    . ..|.  | | .|. .  ||||....      ..    . ....|||||.|||||||    . .||. ..
nvaiivmitnlvergrrkcdvYWPk..desetygalqvtlieeevlalytvrtlviknlklkkkkqcdteklvrqyhytkWPdhgvPehslp.vLifvkk

QhrDRLRKsiPGLGPTLVHCSAGIGRTGTFLVIDIVLDLIRHYGIdcdIDIQSIIHKLRGQRSGMIQTA
.  .. .|     ||..||||||.|||||..|.| .|  |..  .   ...  .....| ||  ..|| 
s..saank..aeaGPivvHcsaGvgrtGtyivldtllkqiqqena...vnvfgflkhiraqRnflvqte

subfamily_PTPN3_pd Subfamily PTPN3 253-495 7.5e-67 220.2 In-house 32-263 (280) alignment
Range on Protein: 253-495
Range on HMM: 32-263/280.0
DRMEGARIENKSKNRYKNILPYDHTRVKLRNVPdgvIgaDYINANFINGEAPGTDKA--YIASQGTMPDTVADFWQMIVEQNCRLVVMATNPVEKGKHKC
.  .  . || |||||..|||||.|||||.. .      ||||||..| | |.|.    |||.|| ...|..|||||. ||...|.|| |. ||.|. ||
aisaarkpenlsknryrdilpydatrvklkese...t..dyinanyvnmeipstglvnryiatqGPlaktatdfWqmvweqksslivmlttlverGrvkC

TPYWPSSErRPARFGNYVVELLTEDNFDAYTVRRMSVAVGE-GDPREIYQYHYTSWPDHGVPPE-REFLQLIMKIRQHRdrlrksIPGLGPTLVHCSAGI
  |||..|    ..|.. |..  ||.  .| .| . .   |  . |.| |  |..||||||| .  .||... ..|. |           |..|||||||
hqyWPete.deleygefsvkcekedetksyvlrelvlkdketkeerkilqlqylaWpdhgvPddsadflefvervrklr......sgkeePvvvhCsaGi

GRTGTFLVIDIVLDLIRHygiDCDIDIQSIIHKLRGQRSGMIQTAVC
|||| ...... | || .     .. .  |....| ||. ..|||  
grtGvlilletalaliea...aepvypldivrtmrdqramlvqtasq

subfamily_PTPN9_pd Subfamily PTPN9 230-493 3.5e-66 218.3 In-house 12-276 (297) alignment
Range on Protein: 230-493
Range on HMM: 12-276/297.0
EFGKAGFNEEFEQLQTMEHQHKFDRMEgaRIENKSKNRYKNILPYDHTRVKLRNVPDGvIGADYINANFINGEApgTDKAYIASQGTMPDTVADFWQMIV
| || |  .|..... .. . .|....     | .||||...| ||.|||.| .|..    .|||||||..|      ||.|| ||... || |||.|. 
ekgkrGlskeyaeirnepveGtflask..lranleknrytdvlcydetrvvlakvded.easdyinanfvdGyk..qkkafiatqGplkktvsdfWrmvW

EQNCRLVVMATNPVEKGKHKCTPYWPSSERRPARFGNYVVELLTEDNFDAYTVRRMSVA-VGEGDPREIYQYHYTSWPDHGVPPE-REFLQLIMKIRQHR
||... .||.|  ||.|. ||. |||..|   |.||.. |. .  .. ..|.|| . .  | ... |..  . ..||||.||| .  ..|... |.|...
eqevlvivmttrvvergrlkcgqyWpleeessaefgdlsvsnveveeeedykvrvleiknvkteesrkvthfqflsWPdyGvPssaaslldvlekvrekq

DRLRKSI-------PGLGPTLVHCSAGIGRTGTFLVIDIVLDLIRHYGIdcdIDIQSIIHKLRGQRSGMIQTA
  . |..       |   | .|||||||||||||  .|| |. ... |    .|..  ...|| ||. .||| 
alavkelgdewkghpsgPPivvhcsaGiGrtGtfitldiclsrleevgt...vdvvetvkllrtqrafsiqtp

subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 223-495 1.4e-64 213.2 In-house 16-278 (298) alignment
Range on Protein: 223-495
Range on HMM: 16-278/298.0
ARSETEEEFGKAGFNEEFEQLQTMEHQ-HKFDRMEGARIENKSKNRYKNILPYDHTRVKLRNVPdGVIGADYINANFINGEApGTDkAYIASQGTMPDTV
 ... ..... .|...||..|...... ...    . . |||.|||| .|...|..|| |...  .   .||||| |...   |.. |.||.|. .. ||
klaavkkkkkltgyalefqrlnsvsseieeeekevarkpenkkkNRyadiialdssRvvLeked.adeesdYiNAsflhayk.grn.afiatqaPltetv

ADFWQMIVEQNCRLVVMATNPVEKGKHKCTPYWPSSerRPARFGNYVVELLTEDNFDAYTVRRMSV-AVGEGDPREIYQYHYTSWPDHGVPPER-EFLQL
.|||.|..|..   .|| || .|..| |.. |||..  . ...|.  |.|| ...|  ..||.. |    | . ||. | |.|||||.||| .    |.|
edFWrmvteedigtiVmltnleeldktkyhkywPde..gketygeitvsllskeefadlivrklkvskkkeekerevrqlhftsWpdkgvpenatsvldl

IMKIRQhrdrlRKSIPGLGPTLVHCSAGIGRTGTFLVIDIVLDLIRhygIDCDIDIQSIIHKLRGQRSGMIQTAVC
. |.|.      ..  |  | .|.||||.||.||| .|| ||. ..   ..  .|.  ... || .| |..||   
lrkvra.....sqqqagnkpvivqCsaGvgRsGtfiaidsvlervk...keqvvDvfqvvkvlRkkrpgavqteeq

subfamily_PTPN1_pd Subfamily PTPN1 247-493 2e-64 212.1 In-house 17-257 (290) alignment
Range on Protein: 247-493
Range on HMM: 17-257/290.0
EHQHKFDRMEGARIENKSKNRYKNILPYDHTRVKLRNVPDgvigaDYINANFINgeAPGTDKAYIASQGTMPDTVADFWQMIVEQNCRLVVMATNPVEKG
.. ..|.  |  . ||...|||... ||||.|.||..        |||||....  ..  .. || .|| .|.||. ||||. ||... |||  . |||.
keasdfptreaklpenrnlnryrdvspydhsrikleradn.....dyinaslve..leeakrsyiltqGPlpntvdhfWqmvWeqkskavvmlnkvveke

KHKCTPYWPSSER-RPARFG--NYVVELLTEDNFDAYTVRRMSVAV-GEGDPREIYQYHYTSWPDHGVPPE-REFLQLIMKIRQHRdRLRksiPGLGPTL
. ||. |||. |. .   .   .. |.|..|.. . |||| . .      . |||...|||.||| |||     ||....|.|.    |    .  ||..
qikcaqywPqgeeekellledtklkvkliseerksyytvrllelenlktqetreilhfhyttwpdfgvpespaaflkflfkvresG.sls...sdvGpav

VHCSAGIGRTGTFLVIDIVLDLIRHYGIDCDIDIQSIIHKLRGQRSGMIQTA
.||||||||.||| ..| .| || ...    .||.  . .|| .| |.||||
ihcsaGiGrsGtfclvdtclvliekkddlssvdikkvllelrkyrlGliqta

subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 233-493 1.5e-63 209.8 In-house 21-269 (305) alignment
Range on Protein: 233-493
Range on HMM: 21-269/305.0
KAGFNEEFEQLQTMEHQHKFDRMEgariENKSKNRYKNILPYDHTRVKLRNVPDGViGADYINANFINGEApgTDKAYIASQGTMPDTVADFWQMIVEQN
. |.......|.. |.. . .. |    .||.|||.|.| ..|. |..|.. ..    .|||||....|      |.||..|| ...||||||..|||  
dkgleaqykslyeeeesidvgkke....ankaknrlkeitlldddriiltekesld.dsdyinasyvdgyk..rkkkyivaqgPlkntvadfWrliveek

CRLVVMATNPVEKGKHKCTPYWPSSERRPARFGNYVVELLTEDNFDAYTVRRMSVAV--GEGDPREIYQYHYTSWPDHGVPPER-EFLQLIMKIRQHRDR
 . .|| |. || ||.||  ||| |.... .||...|||  | ..  |. |......  .. . | . ||. |.||||||| .   .|.|| ...... .
vstivmltklveggkdkCrqYWpesktekkefgefsvelksektasdyieRklkisiededkesrtvlqyqltdWPdhGvpqfatsllslikrvqkdqkk

LRKsipglGPTLVHCSAGIGRTGTFLVIDIVLDLIRHYGIdcdIDIQSIIHKLRGQRSGMIQTA
 ..      | |||||||.||||.|...|| |. ... ..   .|.  ....|| .| .|.|| 
dkg.....vpllVhCsagvgRtGvfiavdialerlkkEev...vdvfevlkqlRskrmkmvqtl

subfamily_PTPRA_pd Subfamily PTPRA 235-496 3.3e-63 208.5 In-house 33-284 (330) alignment
Range on Protein: 235-496
Range on HMM: 33-284/330.0
GFNEEFEQLQTMEHQHKFDRMegARIENKSKNRYKNILPYDHTRVKLRNVpDGVIGADYINANFINGEApgTDKAYIASQGTMPDTVADFWQMIVEQNCR
 | |||. | . . |  ..    .. ||| |||. ||||||..|| | .. .||  .||||| ||.|      . .||.||   .|| |||.|| ||.  
lfreefnalPagpiqatlela..skeenkeknrvvnilPydfsrvilsvk.eGveesdyinasfidGyk..ekdkfiaaqGPkeetvedfwrmiweqksa

LVVMATNPVEKGKHKCTPYWPSSERrpARFGNYVVELLTEDNFDAYTVRRMSVA-VG----EGDPREIYQYHYTSWPDHGVPPER-EFLQLIMKIRQHRD
 .|| |.  |. ..||. |||.       .||  ||.  |    .|||| . |  ..    | ..| . |.|.||||| ||| |    |.|. |... ..
tivmltelkerkeekcaqywPdeGl..vtyGnirvevedetvlvdytvrkflvqqlpdatrekksrlvrqfhftswPdvGvPfepiGmlkllkkvkklnq

RLRksipGlgPTLVHCSAGIGRTGTFLVIDIVLDLIRHYGIdcdIDIQSIIHKLRGQRSGMIQTAVCY
.      |  |  ||||||.||||||.|.| ||. ..  ..   .|.  ....|| ||. |.||   |
qsa....g..pivvhcsaGvGrtGtfivldavlervkaerk...vdvfefvkrlrlqrpqmvqtdeqy

subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 254-494 3.2e-62 205.1 In-house 20-255 (274) alignment
Range on Protein: 254-494
Range on HMM: 20-255/274.0
RMEGARIENKSKNRYKNILPYDHTRVKLRNVPDGVIGADYINANFINGEApGTDKAYIASQGTMPDTVADFWQMIVEQNCRLVVMATNPVEKGKHKCTPY
. |     ...|||||.||| ...|| |..       ..|||||.| |   ...|||.| || .| ||||||.|| .......|| |.  |. ..||. |
qeeldvfgsqtknryktilPnensrvllesessededssyinanyikGyd.eeskayvatqGPlpntvadfWrmiyqeevqvivmltklkeaneqkCavy

WPSSERR--PARFGNYVVELLTEDNFDAYTVRRMSVAVGEGdPREIYQYHYTSWPDHGVPPER-EFLQLIMKIRQHRDRLRKSipgLGPTLVHCSAGIGR
.| .|      |.|.  ..     . . |.||....   |  .|... | ||.|||| .| .  ..|.|...... |..  .    |.|..|||||||||
fPdaedyeiserygdveikvekiverndysvrklvlkyler.ersvkhywytdWPdhksPddantlldlvleveesreeenak...lapvvvhCsaGiGr

TGTFLVIDIVLDLIRHygiDCDIDIQSIIHKLRGQRSGMIQTAV
|| |. |.| .  .|.   .  .|. .|. .|| .| ||.||. 
tGcfiaisiavrqlre...eivvdvlkivcnlrldrGGmvqtse

subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 228-496 8e-62 203.7 In-house 14-272 (290) alignment
Range on Protein: 228-496
Range on HMM: 14-272/290.0
EEEFGKAGFNEEFEQLQTMEHQHKFdrMEGARIENKSKNRYKNILPYDHTRVKLRNVPDG-VIGADYINANFINGEApgTDKAYIASQGTMPDTVADFWQ
..  |. ||...|..|.. |..|.   . |   .|| .||..||..||  |. ||....      .|||| .|.|     .|.||| || ...|..|||.
ghakgnegfrnqfkmldsgesehtv..tvgltssnkllnRfanivvyddnritLrpisghkDCtneyinAcyikgyk..ekkqyiatqgpvsntlvdFWk

MIVEQNCRLVVMATNPVEKGKHKCTPYWPSSERRParFGNYVVELLTEDNFDAYTVRRMSVAVGE--GDPREIYQYHYTSWPDHGVPPEREFLQLIMKIR
.|.....  .|| || .|.||.||  |||.|. .   .|.. ..|| | ... |. |...|   .  |..... ||. |.|...|  ....   |... .
liwqekvtiivmltniieegkvkCqqYWpdsdtka..ygefsikllneetlneyierklevknknsagakqsvtqyqitnwdstgkvtnpqtillvieem

QhrDRLRKSipGLGPTLVHCSAGIGRTGTFLVIDIVLDLIRHYGidcDIDIQSIIHKLRGQRSGMIQTAVCY
.  .  ||.  | .. .||||...||...|..... ..  .  |    ||. ......| |. |..||...|
y..ktqrkr..gntsivvHCSdtvgrsavfcaaattinkckteg...vidvfqvlksqRiqkpgsvqtvqqy

subfamily_Ptp69D_pd Subfamily Ptp69D 231-492 1.4e-61 203.3 In-house 19-271 (307) alignment
Range on Protein: 231-492
Range on HMM: 19-271/307.0
FGKAGFNEEFEQLQTMehQHKFDRMEGARIENKSKNRYKNILPYDHTRVKLRNVPdGVIGADYINANFINGEApgTDKAYIASQGTMPDTVADFWQMIVE
  . |. .|.|.|..   . . .   ... ||. ||||..| ..|.|||||.... |   .|||||.||.|      | .||.|. .  |. |||.|| |
dtdfglakeyekLear..eidkstkvsekkenalknRyedikafDktRvkLkkin.gkedsdYinasfikgyk..ekkkfiaaqdPveatigDfWRmiae

QNCRLVVMATNPVEKGKHKCTPYWPSSerRPARFGNYVVELLTEDNFDAYTVRRMSVAVGE------GDPREIYQYHYTSWPDHGVPPE-REFLQLIMKI
|.  |.|| .|  || ..||  |||       ..|. .|.|  |.. . |. | ..|.  .       | |.. |||||.|.|  ||   |  |.|| ..
qevtlivmlsnlteknrkkcakYWpie..devqygdilvklvseekhsdyiiReldvskkkeesgevedsrkvvqyhytgWkDskvPevargllklieqv

RQHRDRLrksipgLGPTLVHCSAGIGRTGTFLVIDIVLDlirHYGIDCDIDIQSIIHKLRGQRSGMIQT
|..           .| .|||||| ||.|.|. .|..|.   .   .  .||  ....|| ||. ..| 
relykln......rsPivvhCsaGvgrsgifvaldsllq...qlkaedkvdifetvkdLrsqRnllvqs

subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 234-496 1.3e-60 200.4 In-house 34-280 (319) alignment
Range on Protein: 234-496
Range on HMM: 34-280/319.0
AGFNEEFEQLQTMEHqhKFDRMEGARI-ENKSKNRYKNILPYDHTRVKLRNVpDGVIGADYINANFINGEApgTDKAYIASQGTMPDTVADFWQMIVEQN
  .. || ..  .    .   .. | . .|| |||. |||..|...|||... .|. ..||||| |..|      . |||.|| ...|.||||.|| |.|
tklevefrracklgv..nladqtfanldqnkdknriinilafdknvvklerl.iGeefsdyinasfvtGyq..rkdkyiaaqGPldntladfWrmiweyn

CRLVVMATnpvekgKHKCTPYWPSSERRPARFGNYVVELLTEDNFdaYTVRRMSVAV--GEGDPREIYQYHYTSWPDHGVPPER-EFLQLIMKIRQhrdr
|  .|. |      |.||. |||         ..  |....| .   |.|| . ..    | | |.| |.|.  |||.|||    ....|. |.|     
cstivllt......kdkcsqywplkivikeerfkvkvdsveetae..yvvrdielsedgkekdirkitqfhflGwpdvGvpdypsdlmrlvkkvrh....

LRKSIPGLGPTLVHCSAGIGRTGTFLVIDIVLDLIRHygiDCDIDIQSIIHKLRGQRSGMIQTAVCY
|..   .  . .||||||.||||...|.|..|| ...   .  .|.  ... || ||. ..|  | |
ltskenhranivvhcsaGvGrtGvyivldvlldrmke...ekqvdvynfvrdlrqqrntlvqdlvqy

subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 236-496 1.2e-59 196.5 In-house 12-266 (287) alignment
Range on Protein: 236-496
Range on HMM: 12-266/287.0
FNEEFEQLQTMEHQHKFDRMEGARIENKSKNRYKNILPYDHTRVKLRNvpDGVIGADYINANFINGEApgTDKAYIASQGTMPDTVADFWQMIVEQNCRL
 ..|...|.   .   .   .   . . .|||| ..||.|.||| | .  .|  |.||||||.. .     |.|.||.|| .. || |||....|..   
vdkevdalkedsesstatfkaaeelaavkknryadvlPiddtrvllsa..egelGsdyinanyvasyt..ddeafiaaqgPiaatvrdfwravletrsas

VVMATNPVEKGKHKCTPYWPSSeRRPARFGNYVVELLTEDNFD-AYTVRRMSVAVGEGDP-REIYQYHYTSWPDHGVPPE-REFLQLIMKIRQHRDRLRk
|.. |  ||... ||  |||   ..| | | | | ||  |. .  |.|| . ..  |.   | . |... ||||....|    .........|| .  | 
vitmtreveearlkcykywPer.evPmrvGGysvvlldydikePeygvralrlidletrearvvkqldllswPdkvlaPtavglirfvldvkqhielar.

SIPGLGPTLVHCSAGIGRTGTFLVIDIVLDLIRHYGidcDIDIQSIIHKLRGQRSGMIQTAVCY
.  . || .||...||||.|..| . ....     |    .|.  .. .|| .| ...|..| .
dasevGPlvvhddvGiGrsGillatlvlvsrledlG...rvdvaavvirlreyraalvqavvql

subfamily_PTPN23_pd Subfamily PTPN23 232-494 2.1e-59 195.7 In-house 13-267 (288) alignment
Range on Protein: 232-494
Range on HMM: 13-267/288.0
GKAGFNEEFEQLQTMEHQHKFDRMEGARIENKSKNRYKNILPYDHTRVKLRNVPDgvigaDYINANFINGEAPGTDkAYIASQGTMPDTVADFWQMIVEQ
||......|..|.. ....  .|   .   . .|||...||||||.|||||.  |     ||||| |... .||.   .||.|. .. |..|||.|..||
gktaldkkfkeleqkqdkearkrsiaiaklyseknrsrdilPyDhnRvklrgskD.....DYinAsfvkdlspgcP.dfiatqaPlqstlnDFWlmvyeq

NCRLVVMATNPVEKGKHKCTPYWPSSERRPARFGNYVVELLTEDNFDAYTVRRMSVAVGEGD-PREIYQYHYTSWPDHGVPP-EREFLQLIMKIRQHRDR
  ...|| ... |.||.|.  |||... .. .||.. | |  . . . .  | ... . . |  ...   ..||||..|||    ..||.. ..... . 
kssviVmllskeelgkpkvdrYwPedkgetvkfgdlsvtlksvretethvervlkletldadavksvshlqltsWpelGvPasPetllqfldevesayea

LRKSIPGlgPTLVHCSAGIGRTGTFLVI-DIVLDLIRHYGIDcdiDIQSIIHKLRGQRSGMIQTAV
 ..      | .||||||.||||.| ..  .| .| .. |.    ||  ....|| ||  |.|.  
vqrkskt..PlvvhCsaGvgRtgvfalvyaavrelekgngll...diiqvvsrlreqRrfmvqeke

subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 258-494 2.5e-59 195.5 In-house 16-251 (270) alignment
Range on Protein: 258-494
Range on HMM: 16-251/270.0
ARIENKSKNRYKNILPYDHTRVKLRNVPDGVIgADYINANFINGEApGTDKAYIASQGTMPDTVADFWQMIVEQNCRLVVMATNPVEKGKHKCTPYWPSS
. . .|  |||..|||  .|||.| .. .  . . |||||...|   | .|.|||..| .| |. .||.||.|.. . .||.|. .|||..||  |||..
eaargkklnRyadiLPsPatRvrleeleedsa.taYinAnyvrGfd.gekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkgrkkCerYWpae

ERR--PARFGNYVVELLTEDNFDAYTVRRMSVAvGEGDPREIYQYHYTSWPDHGVPPERE-------FLQLIMKIRQHRDRLRKSipglGPTLVHCSAGI
  .    ..|.  |  |.| . . | ..|. .   .|. |..  ..|..|||||||.| .        |... ..|.....|.|.    .|.|||||||.
pkekvkledgkikvlalseekeegyiltrlrle.ekgeerrlvHfwyntWpdhgvpreedsslstdqllkmlravrrsekeldka....ePllvHcsaGv

GRTGTFLVIDIVLDLIRHYGidcDIDIQSIIHKLRGQRSGMIQTAV
|||||....||.. |. . .    .|. .||..|| .|  ..|. .
gRtGtlialDiavrlLeetk...kvdvlaiieelRkdRmalvqhpe

subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 232-496 2.8e-59 195.6 In-house 22-268 (315) alignment
Range on Protein: 232-496
Range on HMM: 22-268/315.0
GKAGFNEEFEQLQTMeHQHKFDRmeGARIENKSKNRYKNILPYDHTRVKLRnVPDGVIGADYINANFINGEApgTDKAYIASQGTMPDTVADFWQMIVEQ
 | ||....| .    . | .|     .|||| |||| ||..||..||.|  . .   ..||.|||||.| .    . |||.||  . .| |||... |.
tkngfkqdyesipgg.qlhpldv..akkienkqknryiniiaydksrvqlp.llendphsdyvnanfidGyn..kkrryiaaqgpnvasvkdfwrlvfee

NCRLVVMATNPVEKGKHKCTPYWPSSerrPARFGNYVVELLTEDNFDAYTVRRMSVAVGEgDPREIYQYHYTSWPDHGVPPE-REFLQLIMKIRQHRDrl
..  .|| || ||. |.|.  |||        .|.. | .  |. .. |||| .|| .|. . ||..|.||||||| |||     ...|| ...||..  
digkivmltnlvegekrkaekywpdk...kviyGkitvtrkseevnteytvrtlsvvfgd.nirevvqlhytswpdmgvpkytiplmnlirtvkqhht..

rKSIpglGPTLVHCSAGIGRTGTFLVIDIVLDLIRhygIDCDIDIQSIIHKLRGQRSGMIQTAVCY
 .|.   |. .||||||.||||||. .| ||| .    ..  ||.  .|...| .| .|.|.|  |
.nsv...gaivvhcsaGvGrtGtfitldavldqae...aenaidvynfitgvrqnrikmvqvaeqy

subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 261-496 3e-59 195.9 In-house 24-244 (284) alignment
Range on Protein: 261-496
Range on HMM: 24-244/284.0
ENKSKNRYKNILPYDHTRVKLRNVpDGVIGADYINANFINGEApgTDKAYIASQGTMPDTVADFWQMIVEQNCRLVVMATnpvekgKHKCTPYWPSSERR
.|| |||. .||..|...|||... .|. ..||||| ||.|      . |||.|| ...|.||||.|| |.||  .|. |      |.||. |||     
qnkdknrighilafdknvvklerl.iGeefsdyinasfitGyq..rkdkyiatqGPldntladfWrmiweyncstivllt......kdkcsqywplkivi

PARFGNYVVELLTEDNFdaYTVRRMSVAV--GEGDPREIYQYHYTSWPDHGVPPER-EFLQLIMKIRQhrdrLRKSIPGLGPTLVHCSAGIGRTGTFLVI
    ..  |....| .   |.|| . ..    | | |.| |.|.  |||.|||    ....|. |.|     |..   .  . .||||||.||||...|.
keerfkvkvdsveesee..yvvrdielsedgkekdirkirqfhflgwpdvgvpdypsdlmrlvkkvrh....ltskenhranivvhcsagvgrtgvyivl

DIVLDLIRHygiDCDIDIQSIIHKLRGQRSGMIQTAVCY
|..|| ...   .  .|.  ....|| ||. ..|  | |
dvlldrmke...ekqvdvynfvrdlrqqrntlvqdlvqy

subfamily_PTPRK_pd Subfamily PTPRK 234-493 3.3e-59 195.3 In-house 22-263 (314) alignment
Range on Protein: 234-493
Range on HMM: 22-263/314.0
AGFNEEFEQLQTMehqhkFDRMegARIENKSKNRYKNILPYDHTRVKLRNVpDGVIGADYINANFINGEApgTDKAYIASQGTMPDTVADFWQMIVEQNC
 ||.||.| |        .|     . ||..|||...||.||..||.|  . ||   .|||||..|..      .|.|. || ...||.|||... ..||
ygfkeeyeslfeg.....wdaa..kkdenreknrsgdilaydrsrvfliti.dgdpssdyinaalidsyk..rpaafivtqgPlqetvkdfWrlvydenc

RLVVMATNPVEKGKHKCTPYWPSSERRparFGNYVVELLTEDNFDAYTVRRMSVAV---GEGDPREIYQYHYTSWPDHGVPPE-REFLQLIMKIRQHRDR
  .|| |. ||.|. ||. |||   .    .|.  |||.  .    . || ..|     |  . ||. |.....||||.|| . . .|.|. .. .... 
asivmltelvevgrvkClkyWPedtev...ygdikvelvetellaelvvrifrveklargqeeirevrqfqflgWpdhdvPvsatgllklvrrvkksqee

lrksipGLGPTLVHCSAGIGRTGTFLVIDIVLDLIRHYGIdcdIDIQSIIHKLRGQRSGMIQTA
      . |...|||||| ||||||..||||||.|.. |.   .|.  ....|| ... |..| 
......eaGrivvhCsaGaGrtGtfiaidivldmieregv...vdvfnavktlrsrkvnmvete

subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 226-494 3.5e-59 195.2 In-house 12-265 (287) alignment
Range on Protein: 226-494
Range on HMM: 12-265/287.0
ETEEEFGKAGFNEEFEQLQTMEHQHKfDRMEGARIENKSKNRYKNILPYDHTRVKLRnvpdgVIGADYINANFINGEApgTDKAYIASQGTMPDTVADFW
..... |. ||.. |  |. ...... .   .   .|| |||...||..|  || |.         ||||| ||.|     .||.|.... | .|. .||
akghakgnegfknqftvleqvtqred.evthniasqnkdknRltqilvpdnyrvllk.....gehpdyinavfidgyk..ekkafiiaesPmfntarnfW

QMIVEQNCRLVVMATNPVEKGKHKCTPYWPSSERrpARFGNYVVELLTEDNFDAYTVRRMSVAVGE--GDPREIYQYHYTSWPDHGVPPEREFLQLIMKI
..| ..|   .|| ..  |. ...|  |||...     .|.| .||| |.  . |..|.. |   .  ||.... ||..|.|...|  .| .   |... 
kliddrnvtaivmlcqekendeevcyqyWpeeks..vvlGeyniellneevnagyierklevknknkagdkqqvkqyqitnWdstgkvtepqtillviee

RQHRDrlRKsiPGLGPTLVHCSAGIGRTGTFLVIDIVLDLIRHYGIdcdIDIQSIIHKLRGQRSGMIQTAV
. . .  ||  .| .. .||||...||...|. ... ..  .  |.   ||. ..... | |. |..||. 
myktq..rk..rgntsivvhCsdtvGrsamfcaaattinkckteGv...iDvfqvlksqriqkpgsvqtve

subfamily_PTPN14_pd Subfamily PTPN14 236-495 5e-58 191.5 In-house 25-284 (300) alignment
Range on Protein: 236-495
Range on HMM: 25-284/300.0
FNEEFEQLQTMEHQHKFDrmEGARIENKSKNRYKNILPYDHTRVKLRNVPDGviGADYINANFINGEAPGTDKAYIASQGTMPDTVADFWQMIVEQNCRL
   |.|... .... ...   ..  ||..|||.|..|||...||.|    .     .||||  |.    |... ||..|| .. || |||||. ||. .|
vfteyeripkkredalls..taklpenaeknrfkdvlPyednrvelsptken..stgyinassikvsvggkersyivaqgPleltvqdfWqmvWeqgvql

VVMATNPVEKGKHKCTPYWPSS--ERRPARFGNYVVELLTEDNFDAYTVRRMSVA-VGEGDPREIYQYHYTSWPDHGVPPER----EFLQLIMKIRQHRD
.|| |.  |.||.|.  |.|..  ... ..||.. |     .. |... . . .  .  .. |...   || |||||||..     ..|. .  .|.. .
ivmlteeeedgkeksfkyfPkleskkktvefgkfkvttkfsedsdsvittglklkhlpskeertvwhlqytDWpdhgvPeDvkgflsyLeevqsvrrktn

RLRKSIPGLGPTLVHCSAGIGRTGTFLVIDIVLDLIRHygiDCDIDIQSIIHKLRGQRSGMIQTAVC
. ..|     | |||||||.||||  .. |...  . |   . .|||......|| ||  ..||   
seveskeskPPvlvhCsaGvGrtGvlilsdlliatleh...neeidikkvlarLreqrmllvqtlaq

subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 261-493 3.6e-56 185.1 In-house 2-225 (237) alignment
Range on Protein: 261-493
Range on HMM: 2-225/237.0
ENKSKNRYKNILPYDHTRVKLRNVPDGvigADYINANFINGeAPGTDKAYIASQGTMPDTVADFWQMIVEQNCRLVVMATNPVEKGKHKCTPYWPSSErR
||| |||| ||  |||.|| |.    |   .|||||....|   || | |||.|| .  .  |||||. ...| ..|| |  .|. . ||  ||||.. .
enkiknrygnivaydhsrvvlkgagsg...sdyinatylkg.fdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywpstd.q

PARFGNYVVELLTEDNFDAYTVRRMSVAV--GEGDPREIYQYHYTSWPDHGVPPEREflqLIMKIRQHRDRLRKSIPGLGPTLVHCSAGIGRTGTFLVID
|| .| . | |  ...|  |||| . ...     . | |.||..|||||.||| .      ....|..     . ..  || ..|||||.|||| |||||
paaygvltvslkkkeefsdytvrslllskrltlkevrlihqyqftswpdrgvpqqta...allrfrkniinrsphvsesgpwiihcsagvgrtgiflvid

IVLDLIRHYGIdcdIDIQSIIHKLRGQRSGMIQTA
 .|   .   .   .||   .. .  .|  .||| 
amlrqakekkv...vdiynyvysieedrpyiiqtk

subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 259-496 3.8e-56 185.1 In-house 6-231 (250) alignment
Range on Protein: 259-496
Range on HMM: 6-231/250.0
RIENKSKNRYKNILPYDHTRVKLRNVPdGVIGADYINANFINGEApGTdKAYIASQGTMPDTVADFWQMIVEQNCRLVVMATNPVEKGKHkCTPYWPSSE
. .|| |||| .|...|..|| | ..  |   .||||| |..|   .. ||.||.|| ...|. |||.|..|..   .|| || .|..|  .. |||  .
kpqnkeknryadiialdssrvvLekek.gdkesdyinasflhgyd.er.kafiatqgPlqatiedfWrmvleeksgtivmLtnLkesekt.yhqywPvek

rrPARFGNYVVELLTEDNFDAYTVRRMSVAV-GEGDPREIYQYHYTSWPDHGVPPE-REFLQLIMKIRQHRDRLrksipGLGPTLVHCSAGIGRTGTFLV
  . ..|.  |.|| ...|  ||.|.. ..   . | | . |.|...||| ||| . .  |.|. |... ...      | .| .|.||||.||.|.|..
..aekyGdvtvsllskeefadytkrklklskakkaderivrqlhfvvWPdkgvPevatavLellkkvqasqqqa.....gnaPvivqCsaGvgrsGafia

IDIVLDLIRhygIDCDIDIQSIIHKLRGQRSGMIQTAVCY
|| ||. ..   ..  .|.  .|..|| .| .....   |
idavlerlk...kekvvdvfkvikvlrkdrphavesleqy

subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 234-493 3.3e-55 182.1 In-house 19-263 (315) alignment
Range on Protein: 234-493
Range on HMM: 19-263/315.0
AGFNEEFEQLQTMEHqhkFDRMEGARIENKSKNRYKNILPYDHTRVKLRNVpDGVIGADYINANFINGEApgTDKAYIASQGTMPDTVADFWQMIVEQNC
| |.||| .|   .    . .  .   .| .|||||||||.|..||||  . |     ||||| .|..    .|||||||||  . .| |||.|..... 
alfseefhdlpdPdi...yrqrvaretinfkknryknilPldsarvklevi.ddsPdsdyinasyiksvd..ddkayiasqgPlkasvddfwrmvlqekv

RLVVMATNPVEKGKHKCTPYWPSSERRPARFGNYVVELLTEDNFDAYTVRRMsVAVGEGDPREIYQYHYTSWPDHGVPPERE-FLQLIMKIRQHRDRLRK
  .|| |.  |  | ||  |||  .   ..||.. ||||  .     ..|.. |     . | . |...| |||.||. .   .|.|| ...  ...   
ttivmvtkkqegdkikcrqywPdrkadsvefGsikvellsleadtdgvarkl.vtrkseesrtvtqfqftewPdkGvdkqtssllklikevkadngkkef

SIpglgptLVHCSAGIGRTGTFLVIDIVLDLIRHygiDCDIDIQSIIHKLRGQRSGMIQTA
|.      |||||||.|||| .. || |.. |..      .|.  ....|| .|  ..|| 
sl......lvhcsaGvGrtGvvisidevvaqikr...trsvdvfnfvknlrakrpylvqte

subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 261-493 2e-54 179.5 In-house 42-262 (515) alignment
Range on Protein: 261-493
Range on HMM: 42-262/515.0
ENKSKNRYKNILPYDHTRVKLRNVPDGvIGADYINANFINGEapGTDKAYIASQGTMPDTVADFWQMIVEQNCRLVVMATNPVEKGKHKCTPYWPSSERR
 | .||||||||||| .||||  . |     ||.|| .|..    .|||||||||  . .| |||......|   ..| |.  |  | ||. |||     
infkknryknilPydsvrvklevindn.Phsdyfnasyipsf..dndkayiasqgPnkasvddfWrlvlqenvttiamvtklkegdkikcgkyWPdkpgd

PARFGNYVVELLTEDNFDAYTVRRMSVAVGEGdPREIYQYHYTSWPDHGVPPE-REFLQLIMKIRQHRDRLRKSIpglgptLVHCSAGIGRTGTFLVIDI
  .||.. |||.. .     . |.. |  |.   | . |.|.| |||.|||.. . .|.|| ...  ....  ..      ..|||||.|||| .. || 
svkfGsikvelvsleactggikrkltvlkgdd.srtvtqfhfteWPdkGvpkhtssllklikevkadhgqythpl......iihcsaGvGrtGvvisids

VLDlirHYGIDCDIDIQSIIHKLRGQRSGMIQTA
|.    |      .|.  .....| .|  ..|| 
vva...hakttrmvdvfnfvtnirqkrpylvqtq

subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 232-495 3.9e-53 175.7 In-house 21-276 (325) alignment
Range on Protein: 232-495
Range on HMM: 21-276/325.0
GKAGFNEEFEQLQTMEHQHKFDRMegaRIENKSKNRYKNILPYDHTRVKLRNVPDGViGADYINANFINGEApgTDKAYIASQGTMPDTVADFWQMIVEQ
 . ||  ||. | . . . |   |   . |||.|||.||....|..|| |    |    .|||||.... .     . ..|.|  ...|. |.|..... 
dqdgfahefgllpsddgiakkvam...kpenkaknrfknvvaldksrvvletkkddp.ssdyinasylrddk..kkdvflaaqaPltatindlWrlvldW

NCRlVVMATNPVEKGKHKCTPYWPSSERRPARFGNYVVELLTEDNFDAYTVRRMSVA-VGEGDPREIYQYHYTSWPDHGVPPEREFLQLIMKIRQH-RDR
.|  ||. .| ...||..|. |||       .||   |.| | ...  |  |.. |  | .|. | . |... ||.| ||.     |  |... ..  .|
rcs.vvvvlneldlgkdrcavywpkemgksktfGglevklrtieeisdyvhrvldvkqvkkGetrsvkqfqlqswddmGvqkrpatlisilqlvkavser

LRKSIPGLGPTLVHCSAGIGRTGTFLVIDIVLDLIRHygiDCDIDIQSIIHKLRGQRSGMIQTAVC
..    . .| |||||||.||||.|. .  .|. . .   .  .||   ..||| .|  |..|.  
vtantkastpilvhcsaGvGrtGvfislysalakvie...esrvdifgfvkklrkdrpsmvetvdq

subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 259-493 1.9e-50 166.7 In-house 45-270 (297) alignment
Range on Protein: 259-493
Range on HMM: 45-270/297.0
RIENK---SKNRYKNILPYDHTRVKLRNVPDGvIGADYINANFINGEAPgtdkAYIASQGTMPDTVADFWQMIVEQNCRLVVMATNPVEKGKhKCTPYWP
  |.|   .|.|||||||||  ||||. | |    .||.|| |..|        .|..|  |..||||||.|.....   .|| ..  |. | ||. ||.
vaekkvnfeksRYkniLPydssRvkLaivndd.pdsDyvnasfvkgnkh....rlittqmPmkatvadfWamvldeqvstivmlnddnerdk.kcaryWs

SSERRParFGNYVVELLTEDNFDAYTVRRMSVAVGE-GDPREIYQYHYTSWPDHGVPPEREFLQLIMKIRQHRDRLRKSIPGlgPTLVHCSAGIGRTGTF
 .   .  ||. .|.||. ..   .  | ..|. |.    | . ||....|||. |. . .  .|.  | . |.   .   |  | ||||.||.|||| .
dkgvtt..fGdvsvvllsvsereGfikrelevtkgkakarrvvkqyqfveWPdkaverkdsassllklisevrkdfsqnaeg..PllvhclaGvGrtgvl

LVIDIVLDLIRHygiDCDIDIQSIIHKLRGQRSGMIQTA
| || |.  ...   . ..||  ...||| .|  ..|| 
ltidsvvaeakr...ekevdifglvkklrqerpylvqtk

subfamily_PTPRN_pd Subfamily PTPRN 236-493 8.3e-50 164.2 In-house 31-278 (297) alignment
Range on Protein: 236-493
Range on HMM: 31-278/297.0
FNEEFEQLQTMEHQHKFDrMEGARIENKSKNRYKNILPYDHTRVKLRNVPDgVIGADYINANFINGEAPGtDKAYIASQGTMPDTVADFWQMIVEQNCRL
...|.| | . | . .     . . .| .|||.|..|||||.||||..  .     ||||| .|  . |    ||||.|| ...||||||||. || . .
lekewealcayeaepstk.evakaeknvkknrskavlpydhsrvklkeeas.aeksdyinasaildhdpr.apayiatqgplastvadfwqmvweqGvvv

VVMATNPVEKGKHKCTPYWPSSERrpARFGNYVVELLTEDNF-DAYTVRRMSV-AVGEGDPREIYQYHYTSWPDHGVPPEREFLqliMkirQHRDRLRKS
.|. |.  |.| ..|. |||      . .. | |.|..|  . | | || . .  .   . | . |.|. |||..|||..   |   .   . | .. ||
ivnltrleeegvkqckrywpdeGs..evyhiyevhlvsehiwcddylvrsfylknlqtsetrtvtqfhflswpeegvPasaksl...l...efrrkvnks

IPGL-GPTLVHCSAGIGRTGTFLVIDIVLDLIRHyGIDcDIDIQSIIHKLRGQRSGMIQTA
  |   | .||||.| ||||....||.||. . . |.  .||| . . .|| ||.|...| 
yrGrscpivvhcsdGaGrtGvyilidlvlnrllk.Gvk.eidiaatlehlrdqrpglvktk

subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 261-495 1.4e-49 163.5 In-house 7-229 (239) alignment
Range on Protein: 261-495
Range on HMM: 7-229/239.0
ENKSKNRYKNILPYDHTRVKLRNVPDGViGADYINANFINgEAPGTDKAYIASQGTMPDTVADFWQMIVEQNCRLVVMATNPVEKGKHKCTPYWPSSErr
 ||.|||| ||. |||.|| | .. .    .|||||...  .  |. |||||.||..  .  |||.|. ..   ..|| |  .|  |.||  ||| |   
vnkaknryanivtydhsrvvleklsndp.hsdyinasylr.dydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdst..

pARFGNYVVELLTEDNFDAYTVRRMSV-AVGEGDPREIYQYHYTSWPDHGVPperEFLQLIMKIRqhRDRLRKSIPGLGPTLVHCSAGIGRTGTFLVIDI
 ... |  | |   . |  | .| . .  ||. . | .||||.| |||.|||   ..   .. .|  |   . |.||  | ..|||||.||||.||||| 
.skycnlrvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvp...qyatavlglr..rkitkdslpgarpwvihcsagvgrtgaflvida

VLdliRHYGIDCDIDIQSIIHKLRGQRSGMIQTAVC
.|   |.   .  .||   .. .| .|  |.||.  
ml...rqakkqktvdifnyvkairedrphmvqtseq

subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 261-495 1.5e-49 163.3 In-house 6-228 (239) alignment
Range on Protein: 261-495
Range on HMM: 6-228/239.0
ENKSKNRYKNILPYDHTRVKLRNVPDGViGADYINANFINgEAPGTDKAYIASQGTMPDTVADFWQMIVEQNCRLVVMATNPVEKGKHKCTPYWPSSErr
 ||.|||| ||. |||.|| | .. .    .|||||...  .  |. |||||.||..  .  |||.|. ..   ..|| |  .|  |.||  ||| |   
vnkaknryanivtydhsrvvleklsndp.hsdyinasylr.dydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdst..

pARFGNYVVELLTEDNFDAYTVRRMSV-AVGEGDPREIYQYHYTSWPDHGVPperEFLQLIMKIRqhRDRLRKSIPGLGPTLVHCSAGIGRTGTFLVIDI
 ... |  | |   . |  | .| . .  ||. . | .||||.| |||.|||   ..   .. .|  |   . |.||  | ..|||||.||||.||||| 
.skycnlrvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvp...qyatavlglr..rkitkdslpgarpwvihcsagvgrtgaflvida

VLdliRHYGIDCDIDIQSIIHKLRGQRSGMIQTAVC
.|   |.   .  .||   .. .| .|  |.||.  
ml...rqakkqktvdifnyvkairedrphmvqtseq

subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 261-493 2.2e-48 159.6 In-house 32-281 (297) alignment
Range on Protein: 261-493
Range on HMM: 32-281/297.0
ENKSKNRYKNILPYDHTRVKLRNVPDgviGADYINANFINGEAPGTDKAYIASQGTMPDTVADFWQMIVEQNCRLVVMATNPVEKGKHKCTPYWPSSERR
    ||||..|| .| |||||..|.    . |||||...      .|  || .|| . .|| |||....||. | .|| ..  | |..||.|||||..  
sslrknryrdilatddtrvkllrvit...erdyinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmvaklqedGrdkcapywpsvvqe

PARFGNYVVELLT--EDNFDAYTVRRMSVAVGeGDPREIYQYHYTSWPDHGVPPERE----F--------------LQLIM----KIRQHRDRLRKSIPG
  . |..||| |.   |.||   .  . .     . | .    . |||||||| . |    |              | |.      .    . ||   | 
rlkagdvvveflsstsdefdrviltelqliyr.sesrvvrhvqflswpdhGvpsdledlvrfqaqvcscciavpmmlalvemftamvflqleslraempr

LGPTLVHCSAGIGRTGTFLVIDIVLDLIRHYGIDcdiDIQSIIHKLRGQRSGMIQTA
  ..|||||||.||.|  .  |..|. .|.  |    |...|...|| ||. ..|| 
nayllvhcsaGvGrsGvvvlsdvilaklrkkrip...dvaailsilreqrarlvqtl

subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 235-494 2.3e-48 159.7 In-house 21-266 (439) alignment
Range on Protein: 235-494
Range on HMM: 21-266/439.0
GFNEEFEQLQTMEHQHKFDRMEGARIENKSKNRYKNILPYDHTRVKLRNVPdGVIGADYINANFINGEApgTDKAYIASQGTMPDTVADFWQMIVEQNCR
 |.|.||...... ... .    |.  ...|||||.. ..||||| |...| ||  . |||||.|.|    .|| |||.||   .|. |||....|... 
ifkeifekinstspdyaciaslaaqeydqtknrykdvgafdhtrvtlqeip.gvphshyinanyikGyy..ddklyiatqgpkkettddfwrlviekktv

LVVMATNPVEKGKhkctpYWPSSERrpARFGNYVVELLTEDNFDAYTVRRMSVAVGE---GDPREIYQYHYTSWPDHGVPPEREFLQLIMK-IRQHRDRl
 .|| || ||  |     ||||..   . .|. .|    . ..  |..| . |          | . |.||..|||. || .  ..   .. |    |. 
tivmltnlvesyk.....ywpsdae..vcygdiavrvdrnielpnyvirgfkvfnerdttekertvlqfhyiawpdknvpaqashvldflrainsandk.

rKsipGLGPTLVHCSAGIGRTGTFLVIDIVLDLIRhygIDCDIDIQSIIHKLRGQRSGMIQTAV
 .     || .||||||.||||| . .|| |. ..   ..  .||. |.. || ||  |.|. .
.e...eygpvvvhcsagvGrtGtiialdialeqlk...lenkvdikgivkvlrkqrkqmvqalc

0041856 (Phosphotyrosine protein) phosphatases II 262-492 2.5e-48 159.4 In-house 1-156 (182) alignment
Range on Protein: 262-492
Range on HMM: 1-156/182.0
NKSKNRYKNILPYDHTRvklrnvpdgviGADYINANFINGEAPGTDkaYIASQGTMPDTVADFWQMIVEQNCRLVVMATnpvekgkhkCTPYWPsserrp
|..||||..||||||.|           . ||||||.. |  |.|.  .|| || ...|||||..|. |......|..|         . .|||      
nldknrysdilpydhsr...........dldyInanlylgslpatr..fiatqgpllstvadflrmlkelgittivnlt.........eelywp......

arfgnyvvelltednfdaytvrrmsvavgEGDPREIYQYHYTSWPDHGVPPEREFLQLIMKIRQhrdrlrksipGLGPTLVHCSAGIGRTGTFLVIDIVL
                             |  .|...||.|..|||||||. .|.|..| ....            ||.|||||||.|||||. ......
.............................ellerlgiqylylpwpDhgvpdldelldfieevle..........eggpvlVHCsaGvgRtgtlvaaylmk

DLirhygidcDIDIQSIIHKLRGQRSGMIQT
 |        ......... .| .|.||..|
kl........gvsleeavklvrsrRpgmvit

subfamily_ptpA1_pd Subfamily ptpA1 249-469 1.7e-47 157.1 In-house 34-261 (418) alignment
Range on Protein: 249-469
Range on HMM: 34-261/418.0
QHKFDRMEGARIENKSKNRYKNILPYDHTRVKLRNVPDGvIGADYINANFINGEAPgtdKAYIASQGTMPDTVADFWQMIVEQNCRLVVMATNPVEKGKH
    .  || .  | ||||| |||| .||||.|... |   |.||||||.|.|  |   | .|..|| .|.|.||||.|. |. ||..|| .   |. . 
vgpsetsegdkkhntsknrytnilpvnhtrvqlkkiqdk.egsdyinanyidgayp...kqfictqgplpntiadfwrmvwenrcriivmlsresencri

KCTPYWPSS---E------RRPARFGNYVVELLT--EDNFDAYTVRRMSVaVGEGDPREIYQYHYTSWPDHGVPPE-REFLQLIMKIRQHRDRLRKSIPG
||  |||     |           || | |||.   .|       | . .   ||. |.| ||.|  |||| .|   . | ||.  | ......  |   
kcdrywpeqiggeqfsiygngnevfgtysvelveviqdpereiitrnirl.tfegetrditqyqyegwpdhnipdhtqpfrqllhsitnrqnqiipssdr

LGPTLVHCSAGIGRTGTFLVIDIVLDLIRHYGI
  | .||||||.||||||    |..  . ||  
nvpiivhcsagvgrtgtfctavimmkkldhyfk

subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 233-496 5.6e-47 154.9 In-house 14-282 (301) alignment
Range on Protein: 233-496
Range on HMM: 14-282/301.0
KAGFNEEFEQLQTMEHQHKfdrMEGARIENKSKNRYKNILPYDHTRVKLRNVPD-GVIGADYINANFINGEApgTDKAYIASQGTMPDTVADFWQMIVEQ
. .|.|....|...|...    . | . |||  ||.||| .||. |. |.. |.  .   .||||..|.|      |..||.|| |  |..|||..|...
snkfeeqykelkegedksc...tvglseenkalnrfknitvyddnriilkpkpnldlcqreyinasyidgys..ekkkfiaaqgpmkktlvdfWrliwqe

NCRLVVMATNPVEKGKHKCTPYWPSSERRPARFGNYVVELLTEDNFDAYTVRRMSVAVGEGD----------------PREIYQYHYTSWPDHGV-PPER
    .|| ||  |. |.||. |||.|| .  .||.  |.|  | ..  ...|...| . .|                 .... |.. |.||..|| .  |
kpvsivmvtnlkegtkskceqywpnseaeseefgpftvtlvneqvyPdfvirqlnvkiqdgsnngyierkfkvksdksswdvlqlqvtdWpqdGvvrepr

EFLQLIMKIRqHrdrlRKSIPGLGPTLVHCSAGIGRTGTFLVIDIVLDLIRHYGIdcdIDIQSIIHKLRGQRSGMIQTAVCY
  || | ..  |    |.  .| || .||||....|.|..  ..| |.  .  |.   .|.  ... .| .. |...|  .|
tvLqviddvi.h....rqqkigggpvvVHCSdtVsrsGvYcsvsiglEQckaegV...VdvfqvtkavrrskpgaVtTLeqy

0051429 (Phosphotyrosine protein) phosphatases II 291-494 2.4e-44 147.3 In-house 4-212 (272) alignment
Range on Protein: 291-494
Range on HMM: 4-212/272.0
ADYINANFINGEapGT---DKAYIASQGTMPDTVADFWQMiVEQNCRLVVMATNPVEKGKHKCTPYWP----------SSERRPARFGNYVVELLTEDNF
 .||||....|   |    ......|.| .| |.||||..  |.... .|. ....|.|..|| .|||          ...  . ..|...| || | ..
sgyiNardvggy..grvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseell

DAYTVRRMSVAV--GEGDPREIYQYHYTSWPDHGVPPEReFLQLIMKIRQhrdrlrksipgLGPTLVHCSAGIGRTGTFLVIDIVLdliRHYGIDCDID-
. |..|.. .    . |..||....|||.|||||||.|  .|.|.  ...            || |||||||..||||. .....|   .  . .. .| 
ldyilrellltlllsagearevmhlhytdwpdhgvpqea.llellellld...........ggpvlvHCsaGkdRTGtvvalllll...lgvsletivdd

-------IQSIIHKLRGQRSGMIQTAV
       .. ....|| || |..||  
Ylltnlyleeaveelraqrpgavqtee

subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 252-496 5.1e-43 141.8 In-house 46-272 (290) alignment
Range on Protein: 252-496
Range on HMM: 46-272/290.0
FDRMEGARIENKSKNRYKNILPYDHTRVKLRNVPDGvigaDYINANFINGeapgTDKAYIASQGTMPDTVADFWQMIVEQNCRLVVMATNPVEKGKHKCT
..|    .  .  |||||..   | ||| |..  ||    ||. ||...|    ..  .| .||.. ||| |.|.|.....   .||  . .|.|| || 
lerkifdkntefkknrykdvvcndktrvilkdGydG....dyvhanyvkG....lkamfiltqGalkdtvidiwrmvlqekvaaivmlceliedGkakce

PYWPSSERRPARFGNYVVELLTEDNFDAYTVRRMS-V-AVGEGDPREIYQYHYTSWPDHGVPPERefLQLIMKIRQhrdrLRKSiPglGPTLVHCSAGIG
.|.|  | .   ||.. |    ||. || .....  |  . .|    .. ..  ||||. |.     | |.  .|     |||  .  ||  ||||||||
qyypekeGevltfGeitvlcseeddkdaniikktlsvrdkdsGkehklkhlkikswpdksvalst..lallrtlri....lrka.s..GpvvvhcsaGiG

RTGTFLVIDIVLDLIRHyGidCDIDIQSIIHKLRGQRSGMIQTAVCY
|||||  |.. |... . |   ..|.  ..  ||  | . .|  . |
rtGtfvaievglqilld.G..keldlldlvralrnsrlnsvqvdiqy

0049772 (Phosphotyrosine protein) phosphatases II 255-493 6.2e-43 143.1 In-house 39-266 (314) alignment
Range on Protein: 255-493
Range on HMM: 39-266/314.0
MEGARIENKSKNRYKNILPYDhTRVKLRNVPdgVIGADYINANFINGEapgtdKAYIASQGTMPDTVADF----------WQMIV--EQNCRLVVM----
. .   .|..||||..|||.| .||.| ..|  | | |||||....|      ...||.|| .. || ||          |.|..  ..|.| .||    
lvadlflnrdknryldilpad.nrvilpglp..vsgsdyinasyvdgf.....lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivmsrde

-----------------ATNPVEKGkhkctpywpsSERRPARFGNYVvelltednfdayT-------VrrmsvavgegdPREIYQYHYTSWPDHGVPPER
                  ... ..|          .|  .|.. ..             .       .           .|....|... .||...|...
vladelsrLdaAlgKtpllildgng..........neptaadlellk............eelydpelf...........erlgikylripvpDgsaplle

EFLQLIMKIRQHrdrlrksiPGLGPTLVHCSAGIGRTGTFLVIDIvldLIRHYgidcDIDIQSIIHKLRGQRS-----GMIQTA
 |....  |...        .  ||.||||.||.||||||.|...   |....    ..... ... .| .|.     |.|.. 
dfdeflefieea........dkggpvlvHCkaGkgRtgtfvvaay...lmkll....gvsleealedvrlkRpinpnpgfieql

subfamily_CG7180_pd Subfamily CG7180 252-492 2.1e-42 139.8 In-house 32-275 (296) alignment
Range on Protein: 252-492
Range on HMM: 32-275/296.0
FDRMEGARIENKSKNRYKNILPYDHTRVKLRNVpDGVIGADYINANFINGEApgTDKAYIASQGTMPDTVADFWQMIVEQNCRLVVMATNPVEKGKhKCT
 |   | | ||. |||. ...|||..|| |... ||    ||||| ....     .|.||  .. . .|| .||... ....  ||. |.. .  | .. 
gdCagglrkenreknrdvkvvPyDynRvvLekl.dGeeksdYinavyvdsfl..kkkeyivteapkketvdefWrlvydeeisavvvLtktfdfak.myp

PYWPSSErrPARFGNYVVELLTEDNFDAYTVRRMSVAVG-----------EGDPREIYQYHYTSWPD-HGVPPE-REFLQLIMKIRQHRDRLrKSIPGLG
 |||      ...|. .||...|... . . | . .              . . | . ....| |.  . ||     ...|. ..|. |..  .  |  |
sywpnks..keqygeifveiveekqyanlkirtfkltkkivalteqekqvkaetRivklfqlteWeledkvPlstnalielrrrvrlwrekv.dedpeeg

PTLVHCSAGIGRTGTFLVIDIVLDLIRHygiDCDIDIQSIIHKLRGQRSGMIQT
|..|..| | .|.| .| ||. |.|...   .  .|.   . .|| .| .....
PvvvvssdGasRsGvylaidanlelvek...eeevdvFeavktlrrsRpqLven

0046846 (Phosphotyrosine protein) phosphatases II 289-493 3e-39 129.9 In-house 10-159 (176) alignment
Range on Protein: 289-493
Range on HMM: 10-159/176.0
IGADYINANFINGEApgtdkaYIASQGTMPDTVADFWQMIVEQNCRLVVMATNPVEKGKHKCTPYWPSSERRPArfgnyvvelltednfdaytvrrmsva
 . ||||||.| | .      .|| || .|.|.|||..|. |.....||. |..||.|..||. |||  |.                             
ldldyinanlilgsr......piatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgi..........................

vgegdpreiyQYHYTSWPDHGVPPEREFLQLIMKIRQHRDRlrksipGlGPTLVHCSAGIGRTGTFLVIDivldLIRHygiDCDIDIQSIIHKLRGQRS-
          ||... |||||||. . .|.|.  ||.....      | ||.|||||||||||||.....    |...   ....... .....| ||. 
..........qylhlpwpDhgvpdlelllellefirealke......g.gpvlVHCsaGigRtgtlvaay....llel...ekglsveealalvreqRpl

GMIQTA
|..|| 
gavqtp

subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 235-493 1.5e-38 127.4 In-house 7-252 (283) alignment
Range on Protein: 235-493
Range on HMM: 7-252/283.0
GFNEEFEQLQTMEHQHKFDRMEGARiENKSKNRYKNILPYDHTRVKLRNVPDgvigaDYINANFIN-GEAPGTDKAYIASQGTMPDTVADFWQMIVEQNC
...  .|.|. .   ..   .. |. ||| |||...|.|.|  ||.|.. .      ||||| ||   .    || ||..|. . .|| |||.|. ... 
nnklfrevlkrlsvpdldadiasad.enkrknrnqeivpadqwrvelksesr.....dyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfdeki

RLVVMATNPVEKGKHKCTPYWPSseRRPARFGNYVVELLTEDNFDAYTVRRMSVAVGEGDPRE--IYQYHYTSWPDHGVPPEREFLQLIMKIRQHRDRLR
  .|| |.  |  . ||. |||.  |    .|.. | |  |   ...... . . |      .  .  | .  | . |  .  . |  . |..  . . .
taivmltklqedlrikCsqyWPk..rGsedyGeftvtlrkettsnsfiikelllrvnssakstlllahyqvidWleygeqaiinslvkfnkvislqtesk

KsipglGPTLVHCSAGIGRTGTFLVIDIVLDLIRHYGIdcdIDIQSIIHKLRGQRSGMIQTA
|     || .||||.|||||..|. .   .. ..   .   .|. .... .| || ...|| 
k.....gPivvhCstgiGrtavfiaasasvkdaltesv...vdvfavvkimreqrmmavqtl

subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 231-495 4.6e-38 125.7 In-house 19-275 (305) alignment
Range on Protein: 231-495
Range on HMM: 19-275/305.0
FGKAGFNEEFEQLQTMEhqhKFDRMEGAR-IENKSKNRYKNILPYDHTRVKLrnvpDGVIGADYINANFINgeAPGTDKAYIASQGTMPDTVADFWQMIV
 | ||. .||  .. ..    |..|.  .  ... |||||..   |. ||||    .|    .|| ||..   .|   | .| .|  . .| |||| | .
kgpaglraefvamkrfn...dfekmkafkeaqeagknrykdvgcldnnrvkl....egpwpheyihanyvs..tptnpkrfictqaplektcadfwymcl

EQNCRLVVMATNPVEKGKHKCTPYWPSSERRPARFGNYV--V--------ELLTEDNFDAYTVRRMSVAVGEG-DPREIYQYHYTSWPDHGVPPER-EFL
...   . |  | .||| .||. |..| ..    | .    .        .|  ... .|   . . |  | | . | . .||.  ||| |||.     |
qdkveaifmlcnllekgakkcleyfaskdkdvlefeekgqkisvkfessvtlkfrkdakakvtetvlviegpgekarkvthyhwidwpdrgvpaadlail

QLIMKIRqhrdrlrksiPGLGPTLVHCSAGIGRTGTFLVIDIVLDLIRHYGI-DcdiDIQSIIHKLRGQRSGMIQTAVC
.|. | |          |  ||. |||||||||||. .... .|| .    | .   | . |. |.| ||   |||   
ellekar..........pskgpivvhcsagigrtgsvvmleyildqllagqiie...dtdkilqkireqrnnsiqtdaq

0036282 (Phosphotyrosine protein) phosphatases II 291-492 4.8e-38 125.9 In-house 2-155 (174) alignment
Range on Protein: 291-492
Range on HMM: 2-155/174.0
ADYINANFINGEAPGTdkAYIASQGTMPdtvadFWQMIVEQNCRLVVMATNPVEKGKHKCTPYWPSserrparfgnyvvelltednfdaytvrrmsvaVG
 |||||.....    .   .||.|| ..     ||.|. |.... ||| ....|.|..||  |||.                                  
sdyinaspldlsyitp..rliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe................................lr

EGDPREIYQYHYTSWPDHGVPPEREFLQLIMKIRQHRDRlrksiPGLGPTLVHCSAGIGRTGTFLVIDIVLDLIRhygiDCDIDIQSIIHKLRGQRSGMI
|   |...||.|. |||||||.  ..|...  ..... .     .. ||.|||||||.|||||. .....| ...       .|. .....|| ||.||.
edlerlgiqylylpwpDhgvpdlsillefvkfveealse.....dpggpvlVHCsaGvgRtGtlvaaylmlrgll....eslvdaldlvrelRlqrpgmv

QT
||
qt

subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 233-494 8.4e-37 121.5 In-house 19-223 (392) alignment
Range on Protein: 233-494
Range on HMM: 19-223/392.0
KAGFNEEFEQLQTMEhqhKFDRMEGARIENKSKNRYKNILPYDHTRVKLRNVpDGVIGADYINANFINGEapGTDKAYIASQGTMPDTVADFWQMIVEQN
 | | ||| .|   .    ...  . .  |. ||||||||||| .||||  . | .   ||.|| .|..    ..||||||||  . .. |||.|. ..|
salffeefhdlpgpd...iypqtvaqkeinlkknryknilpydsarvklevi.ddipdsdylnasyipsf..dnekayiasqgpnaaslddfwrmvfqen

CRLVVMATNPVEKGkhkctpywpsserrparfgnyvvelltednfdaytvrrmsvavGEGDPREIYQYHYTSWPDHGVPPERE-FLQLIMKIRQHRDRLR
   ..| |.  |                                                | | . |.|.| |||..||     .|..| ... .  .  
vttiamvtklkegd...........................................kgddartvaqfhftewPdkdvpkhtssllkfikevkadfGqyt

KsipglgPTLVHCSAGIGRTGTFLVIDIVLDlirHYGIDCDIDIQSIIHKLRGQRSGMIQTAV
.      | ..|||||.||||  . || |.    |      .|.  .. ..| .|  |.||  
h......pliihcsagvgrtgvvisidsvva...hakktrmvdvfnfvtnirrkrpymvqtke

0043147 (Phosphotyrosine protein) phosphatases II 291-493 1.1e-36 121.5 In-house 5-147 (172) alignment
Range on Protein: 291-493
Range on HMM: 5-147/172.0
ADYINANFINGEApgTDKAYIASQGTMPDTVADFWQMIVEQNCRLVVMATNPvekgkhkctpywpsserrparfgnyvvelltednfdaytvrrmsVAVG
 |||||.....      . .|| || .. |.||||.|. |......|..|.                                             .  .
sdyinasyldlyy..ipdrfiatqgplrntladfwrmlkelgithivnltel............................................lydp

EGDPREIYQYHYTSWPDHGVPPEREFLQLIMKIRQHR--DRlrksipgLGPTLVHCSAGIGRTGTFLVIDIVLdlirhygidCDIDIQSIIHKLRGQRSG
|.  |...||.|..|||||||. . .|...  |...   ..        ||.|||||||.|||||. .....|         ...... ... .| .|.|
ellerlgiqylylpwpDhgvpllellleflefidellalsp.......ggpvlVHCsaGvgRtgtlvaaylml.........lglsleeavalvrekRpg

MIQTA
..|. 
avqnp

0049260 (Phosphotyrosine protein) phosphatases II 308-493 8e-36 118.4 In-house 9-136 (152) alignment
Range on Protein: 308-493
Range on HMM: 9-136/152.0
KAYIASQGTMPDTVADFWQMIVEQNCRLVVMATNPVEKGKHKCTPYWpsserrparfgnyvvelltednfdaytvrrmsvavgegdpreiyQYHYTSWPD
...|| ||..| |.||||.|. |.... .|| |...|.|| ||  |.                                            ||... |||
fefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi............................................qylhlpwpD

HGVPPEREFLQLIMKIRQHRdrlrkSIPGLGPTLVHCSAGIGRTGTFLVIDIVLdlirhygidCDIDIQSIIHKLRGQRSGMIQTA
||||.  ..|. .... ...      .   ||.|||||||.|||||. .....|         ...... ..  .| .|.|.... 
hgvpdlsqlllflllfiekl.....aldkggpvlVHCsaGvgRtgtlvaaylml.........lgvsleeavalvrekRpgavpnp

subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 258-496 2.7e-35 116.8 In-house 37-266 (307) alignment
Range on Protein: 258-496
Range on HMM: 37-266/307.0
ARIENKSKNRYKNILPYDHTRVKLRNvpDGvIGADYINANFInGEApGTDKAYIASQGTMPDTVADFWQMIVEQNCRLVVMATNPVEKGKHKCTPYWPSS
|   |  ||||...   |..|. ..   || . .||| ||.. | |    | .|..|| . .|. .|| |.....   |.|  . .| .| ||  |||  
afsantdknryqdvkcqdkgrivvkf..dg.lasdyihanyl.gia.ikpkkficaqgplentqysfwamaiqekvesvimlckvielakikceqywple

ERRPARFGNY---------VVELLTEDNfDAYTVRRMSVAVGEGdPREIYQYHYTSWPDHGVPPER-EFLQLIMKIRQHRDrlrksipglgPTLVHCSAG
| .   ||.           .. |. |. |   |  . |  ...  | | .. .. |||.|||.     . |.  .| ...          | .||||||
egqklvfgeapntisvanlgakklapde.dlinvttlkvdwaqk.srtiqhlqwenwpdrgvpqinltainlleavrydtn..........pvvvhcsaG

IGRTGTFLVIDIVLDLIRhYGIDCdIDIQSIIHKLRGQRSGMIQTAVCY
.||.|| . | .| | .   ||.|  |.. ....|| ||   ||| . |
vGrsGtivaislvqdkmi.aGinc.kdmkklveelrsqrhyaiqteaqy

0044763 (Phosphotyrosine protein) phosphatases II 273-493 4.2e-34 113.1 In-house 1-157 (178) alignment
Range on Protein: 273-493
Range on HMM: 1-157/178.0
PYDHTRVKLRNVpDGVIGADYINANFINGEapgtdkAYIASQGTmpdtvADFWQMIVEQNCRLVVMATNPVEKGKHKCTPYWPSSERrparfgnyvvell
|.|.|||.| |.  |. ..|||||..| .        |..|...     ||..... |......|. |...| |..|| ||||...              
pldrtrvllsnl.eglersdyinaseilpg......lylgslpp.....addlellkelgithivnlteelelgflkcdpywpeeag.............

tednfdaytvrrmsvavgegdpreiYQYHYTSWPDHGVPP-EREFLQLIMKIRQHRDRLRksipglGPTLVHCSAGIGRTGTFLVIDIVLDLirhygidc
                         .||... .||||||.  . ||...  |....|.        ||.|||||||.||.||. ...... |        
.........................iqylhipipDhgvpdllehflefvefieealdekg......gpvlVHCsaGvgRsgtlvaaylmkkl........

DIDIQSIIHKLRGQRSgMIQTA
.......|. .| .|. .... 
glsleeaielvrerRp.ivpnp

subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 248-496 8.8e-34 111.5 In-house 42-278 (305) alignment
Range on Protein: 248-496
Range on HMM: 42-278/305.0
HQHKFDRMEGARIeNKSKNRYKNILPYDHTRVKLRNVPdgviGADYINANFINGeAPGTDKAYIASQGTMPDTVADFWQMIVEQNCRLVVMATNPVEKGK
 |  |.  . | | ...||||...   |.. ||| . .     .||| ||..       .| .|..|| . .|. .|| |.....   .||  . || ||
tqvafnanqsadi.aitknryqdvpcqdqsavkldkps....psdyihanyvgc.pmipekrficaqgpldqtidefwwmviqnkveqivmlcktvelgk

HKCTPYWPSS--ERRPARFGnYVVELLT-EDNFD---AYTVRRMSVAVGEGDPREIYQYHYTSWPDHGVPPER-EFLQLIMKIRQHRdrlrksIpglgPT
 ||. ||| .  |..  . |  ||| ..    ..      .  . ..   ..   . . ..| ||| |||| .   |.|.  ||  .      .    | 
lkcaqywpaaqgeklelksg.ivvenvsgskpmerdaeiqitllnltysgdqkmsvrhlqwtewpdrgvppckltslellsairgsk......v....pi

LVHCSAGIGRTGTFLVIDIVLDLIRHYgIDCDiDIQSIIHKLRGQRSGMIQTAVCY
.|||||||||||| . |. .|. |     .|   .  ... || ||.  ||. | |
vvhcsagigrtgtivaieyilekiaen.kpcp.pmpelvkalrdqrafsiqndvqy

subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 262-492 6.1e-33 108.7 In-house 37-254 (281) alignment
Range on Protein: 262-492
Range on HMM: 37-254/281.0
NKSKNRYKNILPYDHTRVKLRN-VPDgVIGADYINANFINgeAPGTDKAYIASQGTMPDTVADFWQMIVEQNCRLVVMATNPVEKGKHKCTPYWPSSERR
|. |||| ||   | .||.|.  .|.    .||| ||.|   .|   . || .||   .| ||||.|| ..|   .||  . .|  . ||. |.|   . 
nnkknrylnipcldisrvqlkvkmpn.knstdyihanyir..spflkrgyiltqgpkketradfwrmiwqenttaivmlcqfletnrekcaeyfprnahc

PARFGNYVVELLTEDNFDAYTVRRMSVAVgEGDPREIYQYHYTSWPDHGVPPEREFLQLIMkiRQHRDRlrkSIpglgPTLVHCSAGIGRTGTFLVIDIV
  .| .. |.        .    |. ..  ||. | | .. .  |||  ||   | .  |.  |. | |   |     | ..|||||.||.||.. ..| 
clqfdklsvsyedstvnkslvttrlnlsy.egetrlithwlwkewpdwqvpessevmlkil..rkirar...st....ppvihcsagvgrsgtlmaveia

LDLIRHYGIDCdiDIQSIIHKLRG-QRSGMIQT
|. |. .      ||. |. .||   |.  .||
lqsihshftlp..dikqivshlrvtgraasvqt

subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 233-493 8.5e-32 105.2 In-house 5-245 (267) alignment
Range on Protein: 233-493
Range on HMM: 5-245/267.0
KAGFNEEFEQLQTMEHQHKFdRMEGARIENKSKNRYKNILPYDHTRVKLRNVPDGvigadYINANFINGEApgTDKAYIASQGTMPDTVADFWQMIVEQN
.  ...|||... . ...          .|. .||. . ||||.||| ||.  .      |||| ...|    | .|.|. |...  |..||...| .|.
eceiekefelikkisdtsst.isqsiaeknqernrlddnlpyddtrvilrtkeee.....yinasyvegyk..tknafivtqdplkntitdfltvihdqk

CRLVVMATNpVekGKHKCTPYWPSSERRPARFGNYVVELLTEDNFDAYTVRRMSVAVGEGDPREIYQYHYTSWPDHGvpPEREFLQLIMKIRQhRDRLRK
.  .|. |. |  .. .   .||    .  .. . .||   | . . | .  . . . .   ...  |.|  |       .. .|. .. |   ...| .
vpvivlltk.v..ftdnirlfwPPkmgqakkyqdltvehslekeendyqiitlelkfknesahnvtlyyykkwnint..nnkpylkplfgila.knqlen

sipGLGPTLVHCSAGIGRTGTFLVIDIVLDLIRHYGIdcdIDIQSIIHKLRGQRSGMIQTA
   |  | .|.||.|.||.|||||||  |. ... |.    ||   . |.| || |...| 
...gnrPlvvacsdGvGrsGtflvidsqleraktegv...sdifdflrkirsqriglvdtk

subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 259-495 4.5e-31 103.0 In-house 40-259 (288) alignment
Range on Protein: 259-495
Range on HMM: 40-259/288.0
RIENKSKNRYKNILPYDHTRVKLRNVPDGvigadYINANFINgeAPGTDKAYIASQGTMPDTVADFWQMIVEQNCRLVVMATNPVEKGKHKCTPYWPSSE
 |.| ...||.|.   | ||||| . ||      ||.|| .   .   ..  | .|  .  |.  .|.|..|.. . .|| .. .||||.|   |.||  
fianptrdryenlprcditrvklsddpdf.....yiaanvvs..sakykrrlicaqaPlngtieelWkmllesdveyivmlcellekGkeksaeyfPskl

RRPARFGNYVVElLTEDNFDAYTVRRMSVA--VGEGDPRE-IYQYHYTSWPDHGVPPEreFLQLiMKIRQHRDRLRKsipglgPTLVHCSAGIGRTGTFL
 . ||.| .      ... |   . ..|.     ||. .  . . |.  |.|.||| .  .|   ... .    |.|      | .||.|||.|||||. 
Gekarigrlctv.vkkkradidklvkvsllriskegeekvivkilhlleWdddgvPen..ylsp.lrllevlkslqk......PivvhssaGvGrtgtli

VIDIVLDLIRhygIDCDIDIQSIIHKLRGQRSGMIQTAVC
.| |.|. .|   .| .. |.|...||| .|   |||   
lilialeslr...lddflgirsllaklreerfkaiqtemq

subfamily_CG42327_pd Subfamily CG42327 257-423 3.2e-29 96.6 In-house 23-190 (319) alignment
Range on Protein: 257-423
Range on HMM: 23-190/319.0
GARIENKSKNRYKNILPYDHTRVKLRNVPDGViGADYINANFINGEApGTDKAYIASQGTMPDTVADFWQMIVEQNCRLVVMATNPVEKGKHKCTPYWPS
   .  | |.|. |..|  .||| |....|      |..|... |    ..  |||.| .. |. .|||... ||. | .| .|.. |.| ..|. |.|.
evPvtskdksrvinvvPlPetrvvlqrigddd.kdeyldasyvrGyd.dapnsyiaaqvsledsssdfwrtvweqqsrvivqltdlselGikvcaeylPt

SERRPA--RFGNYVVELLTEDNFDAYTVRRMSVA-VGEGDPREIYQYHYtSWPDHGVPPEREF-LQLIMKI
.|  .    .|.. | |   .  | | .  . .  | .   ||.  | |  |.. .|| | .  . .....
ketldntslyGdilvtlkgrevkdryaistlllkrvdkeesrelthywy.kwleaevPaeeaaliamllev

0051082 (Phosphotyrosine protein) phosphatases II 291-493 4.7e-28 93.1 In-house 3-139 (151) alignment
Range on Protein: 291-493
Range on HMM: 3-139/151.0
ADYINANFINGEapgtdkaYIASQGTMPdtvaDFWQMIVEQNCRLVVMATNPVEKGkhKCTPYWPSSErrparfgnyvvelltednfdaytvrrmsvavg
 ||||.... |        ...|.| ..    ||.... |.... .|. ....| |  .|. |.|. .                                
sdyinfsyvtgg.......lyrsggpla....dflellkelgiktivnlrseeerg..ycpeylpelg................................

egdpREIYQYHYTSWPDHGVPPEREFLQLIMKIRQHrdrlrksiPGLGPTLVHCSAGIGRTGTFLVIDIVLdlIRhygidcdIDIQSIIHKLRGQRSGMI
    .|........|||.|.|   .... .... ..        .. ||.|||||||.|||||. .....|   .       ........ .| .| |..
....ievlhipildwpdpglplsfdavleflellld........kkngpvlvHCsaGkgRTGtlvalylml..lg.......vsleealeeyrlkrpgvv

QTA
|. 
qpn

PTPc_DSPc_SM00012 397-493 3.1e-27 90.2 In-house 2-93 (105) alignment
Range on Protein: 397-493
Range on HMM: 2-93/105.0
IYQYHYTSWPDHGVPPE-REFLQLIMKIRQHRDRLRKsipgLGPTLVHCSAGIGRTGTFLVIDIVLDLIRHYGidCDIDIQSIIHKLRGQRSGMIQTA
...||||.||||||| |  ..|.|. ......    .     .|..||||||.|||||| ..||.|. ...      .||. |...|| ||.||.|| 
vkhyhytgwpdhgvPeesdsilellravkknknkses....skpvvVhCsaGvgRtgtfvaldillqqleket..kevdifqivkelrkqRpgmvqte

subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 262-493 4.1e-27 89.7 In-house 50-267 (301) alignment
Range on Protein: 262-493
Range on HMM: 50-267/301.0
NKSKNRYKNILPYDHTRVKLrnVPDGVIGadYINANFINGEapGTDKAYIASQGTMPDTVADFWQMIVEQNCRLVVMATNPVEKGKHKCTPYWPSSERRP
.| |.||...    .| |..  . ||      | ||.|. .  |  . .||.|| ...|  ||| |.|  .   .|| .. ||| ..||. | |.. .. 
pkdkhryptvPckPstavev..ivdGkrv..Pihanwipts..GhphrfiatqgPlkntsedfwamlvqydvekivmlgqkvekleekceeylpvkisek

ARFGNYVVELLTEDNFDAYTV--RRMSVA--VGEGDPREIYQYHYTSWPDHGVPPEREFLQLIMKIRQHRDRlrksipglgPTLVHCSAGIGRTGTFLVI
 . | . ... ...      .  |.. |.   |. ..| .  | |..|.|.|||     |  .|.. .. ..         | .|||||||||. .|.  
ldigrfkikiknkelilnkkiskrtlevedstgkfatrtvthyqysewtdrgvPkshaelfdlmelvkksek.........PivvhcsaGiGrsvafigt

DIvldLIRHYGIDCDIDIQSIIHKLRGQRSGMIQTA
..   | |.   |  |...  ...|| .|   .|| 
ey...lareveadptieltealkhlrehrwngvqtn

subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 257-357 5.6e-27 89.4 In-house 42-153 (350) alignment
Range on Protein: 257-357
Range on HMM: 42-153/350.0
GARIENKSKNRYKNILPYDHTRVKLR---NVPD----GVIGADYINANFINGEAPGTD----KAYIASQGTMPDTVADFWQMIVEQNCRLVVMATNPVEK
   .|  .||||||||||.|.||||.   . .|     . . ||||||... . .. .      ||| |. .| || ||...|.. . ..... |. || 
seGvelfaknrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvkvilsltsdvel

GKHKCTPYWPSS
. .||  ||.  
nlekcyrYWqeg

SH2 SH2 domain 3-78 1.9e-26 82.5 Pfam-A 1-77 (77) alignment
Range on Protein: 3-78
Range on HMM: 1-77/77.0
WFHPNISGEEAERMLLTQGFDGSFLVRQSRSNKGDYALSVRRGASVTHIKIQNSGDF-LDLYGGEKFANLTELIQFY
|.| .||.|||||.||... ||.||||.|.|..|||.|||..  .|.|..||.. .  . . ..||| .|.||...|
WyhgkisreeaerlLlegkkdGtFLvReSeskpGdytlsvvddgkvkhyriqslengkyyitenekfsslqeLvehY

subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 257-495 4.8e-25 82.8 In-house 47-278 (310) alignment
Range on Protein: 257-495
Range on HMM: 47-278/310.0
GARIENKSKNRYKNILPYDHTRVKLRNvpDGVIGADYINANFINGEApgTDKAYIASQGTMPDTVADFWQMIVEQNCRLVVMATNPVEKGKHKCTPYWPS
 |  ..  |||| ...  | .||||.   |     ||| ||... .     ...| ||| .  |. |||.|| .. .  ...  . .|.|. ||  ||||
eaykkymhknrysdvvcldtsrvklki..dksryedyihanyvktny..lrstficsqgplqhtiidfwrmifqeraesilllckvgeegrpkcvgywps

SERRpARFGNYVVELLTE--DNFD----AYTVRRMSVAVGEgDPRE-----IYQYHYTSWPDHGVPPEREFlqlimkirQHRDRLRKSIPgLGPTLVHCS
       .|   |  |.|  ..|.    | |     | | | .| .     .   ..  ||| ||| |.             .||   .   || .||||
lgvt.etygcirvtnlsesseefeicnlavtfvpdnvpvde.qpanlkelrvslikwpnwpdrgvpdekch........tvpqrllaqvr.hgpcvvhcs

AGIGRTGTFLVIDIVLDLIRHyGidCDIDIQSIIHKLRGQRSGMIQTAVC
||..|... . ... .| ... |    .|.. .. .|. .|   ||| . 
agkdrlyvvvalklkidkldr.g..lkvdaeevktellksraiciqtelq

subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 262-492 6.5e-25 82.6 In-house 35-255 (285) alignment
Range on Protein: 262-492
Range on HMM: 35-255/285.0
NKSKNRYKNILPYDHTRVKLRNVpdgviGADYINANFINgeAPGTDK-AYIASQGTMPDTVADFWQMIVEQNCRLVVMATNPVEKGKHKCTPYWPSSERR
|   ||| ..   . ||| |.|        ||| |...    || |. .||..|| .|.|..|||.|| ...   |.|    .| |  ||. |.|     
npdlnryadvrcieetrvvlknh.....drdyihaswmr..mpgkdqstyittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekcalyypeklge

PARFGNYVVELLT--EDNFDAYTVRRMSVAVGEGDP-REIYQYH--YTSWPDHGVPPEREFLQLIMKirqhrdRLRKSIPGLGPTLVHCSAGIGRTGTFL
  .||.| . |    |.      .  ..|   |      .|  |     |||.  | .   .  . |       ..|  |   |  ||||||.||| ||.
vvkfgkyeitlteckeeaiagtilnaltvintedasseplymnhvqvpwwpdqlapedarpmielyk......wvkkvnpkekpicvhcsagvgrtatfv

VIDIVLdlIRHYGiDCDIDIQSIIHKLRGQRSGMIQT
 ||     ||    . .|..  |....|  |   .|.
gidyat..irime.npniemldivremramrfqavqs

subfamily_egg_pd Subfamily egg 239-496 3.3e-24 80.1 In-house 19-259 (307) alignment
Range on Protein: 239-496
Range on HMM: 19-259/307.0
EFEQLQTMEHQHKFDRmeGARIENKSKNRYKNILPYDHTRVKLrNVPDGVIGADYINANFINGEaPGTdKAYIASQGTMPDTVADFWQMIVEQNCRLVVM
 .| |. . ..  . .   |  .|. | | | .   | .|||| ... |    |.| || ..|. |     .| .|  . .|| |||.|. ..... .||
rlevleesvdeisltt..aasdnnlekarskrvhckdssrvkl.elrrGqylddfihanrvkGk.pll.nefilaqaplkntvddfwrmvfqeevqyivm

ATNPVEKgkHKCTPYWPSSERRPARF--GNYVVELLTEDNF-D-AYTVRRMSVaVGeGDPREIYQYHYTsWPDHGVPPEREFLQLIMKIRQHRDrlrksi
 |  .|   ..|  ||| .|  ....  |.. .| |  |.  |  ..| .. . || ||  | .  |.  .  . .      |... |.|.         
ltsrkes..erceyywpkaesdslvtvpGslrienlkvdskadplfrvtklkl.vG.gddeerflehwq.gdvnnssdvysplrvlrklrnlsk......

pglgPTLVHCSAGIGRTGTFLVIDIV-LDLIRHygIDCDIDIQSIIHKLRGQRSGMIQTAVCY
    |..|..  |. ...|.. |.|  |.|.|         ..  .  || .|   ..... |
....pvvvqdilGvskaatlvaieiallsllrG..pitkslvlravvflrlrrrlsvesvlly

0048076 (Phosphotyrosine protein) phosphatases II 353-493 4.4e-23 77.0 In-house 2-129 (145) alignment
Range on Protein: 353-493
Range on HMM: 2-129/145.0
YWPSSERRPARFGNYVVE--LLTEDNFDAYTVRRMsVAVGEGDPREIYQYHYTSWPDHGVPPE-REFLQLIMKIRQHRDRlrksipGlGPTLVHCSAGIG
||||       .|.. .   | .  ... .|| ..     |.  |...||.|..|||||||.  . .|...  |......      | ||.|||||||.|
ywpseilpglylgslptaldlellkdlgittvlnl.tselellerlgiqylylpwpDhgvpdllellleflefieealke......g.gpvlVHCsaGvg

RTGTFLVIDIVLDlirhygidCDIDIQSIIHKLRGQRSGMIQTA
||||. .....|         ............| ||.|.... 
Rtgtlvaaylmll........lgvsleealelvrsqrpgavpnp

SH2 SH2 domain 109-184 7.3e-22 67.8 Pfam-A 1-77 (77) alignment
Range on Protein: 109-184
Range on HMM: 1-77/77.0
WFHGQMSGPDSEAALRERGEHGSFLVRASQSQPGRFALSVRCGDAISHIIIRNNGGS-FDVGGGASFTDLTSLVEYY
|.||..|. . | .|.|....|.|||| |.|.|| ..|||.  . . |. |...  . . . ....| .|. |||.|
WyhgkisreeaerlLlegkkdGtFLvReSeskpGdytlsvvddgkvkhyriqslengkyyitenekfsslqeLvehY

0048179 (Phosphotyrosine protein) phosphatases II 385-493 8.4e-22 72.9 In-house 48-131 (144) alignment
Range on Protein: 385-493
Range on HMM: 48-131/144.0
MsvavgegdpreIYQYHYTSWPDHGVPPE-REFLQLIMKIRQHRDrlrksiPGlGPTLVHCSAGIGRTGTFLVIDIVLdlirhygiDCDIDIQSIIHKLR
.           ..||....|||||||.    .|...  |.....      .| ||.|||||||.|||||. ......         .......... .|
e...........giqylhlpwpDhgvpdllellleflefieeale......eg.gpvlVHCsaGvgRtgtlvaaylmk........klglsleealalvr

GQRSGMIQTA
 .|.|.... 
srrpgavpnp

subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 307-492 2.3e-21 70.9 In-house 3-188 (198) alignment
Range on Protein: 307-492
Range on HMM: 3-188/198.0
DKAYIASQGTMPDTVADFWQMIVEQNCRLVVMATNpVEKGKH-KCTPYWPSSERRPARFGNYVVELLTEDNFDAYTVRRMSVAVGE---GDPREIYQYHY
.. |||.|  . .|.||||||. |     .||  .  .| |      |||..|   ...|.  |   |      ||.  . ..         ||| .| .
qrryiatqhplretladfwqmvwetgsghivmvnd.dqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqf

TSWPDHGVPPEREFLQLIMKIRQHRDRLRKSIPglGPTLVHCSAGIGRTGTFLVIDIVLDLIRHyGIDCDIDIQSIIHKLRGQRSGMIQT
||| ..  |    |. ...  |.   .  .      | .|||| | | || |. .|| .           .|.  . ..||  | |.| .
tswkekttpnvalfvgfvvasrevskkyeqekd..apvivhcsdgqgftgvfvaldigvrshee.sktsvvdlfevakrlrqarcgiiss

subfamily_eak_pd Subfamily eak 248-492 2.4e-21 70.5 In-house 38-290 (332) alignment
Range on Protein: 248-492
Range on HMM: 38-290/332.0
HQHKFDRMEGARIENKSKNrYKNILPYDHTRVKLRNVPDGVIGadYINANFIngEAPGTDKAYIASQGTMPDTVADFWQMIVEQNCRLVVMATNPVEKGK
.|.     |.||.|.  .|   .|.|||.  |.| .      |  ||||  .  | .   . || .  .  | |  ||||..||.   .|.  . ||.. 
yqrllsisetarleavnrn.vvkivpydrylvrltssqlnrlG..yinasla..efsevGrkyiltGiasedkvfafwqmvleqkspaivqlledvelkl

HKCTPYWPSSERRPARFGNYVVELLTEDNFDAYTVRRMSVAVGEgDPREIYQYHYTSWPDHGVPPEREFLQLI--MK-----------IRQHRDRLRKSI
 |   |.|   |   .|| . ||     . . . .| . . .|. .  ... |..  | .  .|  ..|| |   ||               .  |.| |
eksdkyfpdktreelkfGildverkefvkrniletrllelskGn.ethrvlhykvfGwtettlpkyedflalrkvmkevGvlllivmksallsstlkkyi

--PGLGPTLVHCSAGIGRTGTFLVIDIVLDLIRHYgIDCDIDIQSIIHKLRGQRSGMIQT
  |     .. .. |  |.|.|.|||... ||    .     .. .| | . .|   . .
htppsfapiiqsarGsaraGvfvvidllirlidnk.kknlysvedlilkvkskrihsvlv

subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 307-492 2.4e-21 70.8 In-house 4-189 (199) alignment
Range on Protein: 307-492
Range on HMM: 4-189/199.0
DKAYIASQGTMPDTVADFWQMIVEQNCRLVVMATNpVEKGKH-KCTPYWPSSERRPARFGNYVVELLTEDNFDAYTVRRMSVAVGE---GDPREIYQYHY
.. |||.|  . .|.||||||. |     .||  .  .| |      |||..|   ...|.  |   |      ||.  . ..         ||| .| .
qrryiatqhplretmadfwqmvwetgsghivmvnd.dqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqf

TSWPDHGVPPEREFLQLIMKIRQHRDRLRKSIPglGPTLVHCSAGIGRTGTFLVIDIVLDLIRHyGIDCDIDIQSIIHKLRGQRSGMIQT
||| ..  |    |. ...  |.   .  .      | .|||| | | || |. .|| .           .|.  . ..||  | |.| .
tswkekttpnvalfvgfvvasrevskkyeqekd..apvivhcsdgqgftgvfvaldigvrshee.sktsvvdlfevakrlrqarcgiiss

subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 260-490 1.2e-20 68.4 In-house 41-259 (312) alignment
Range on Protein: 260-490
Range on HMM: 41-259/312.0
IENKSKNRYKNILPYDHTRVKLRNvpDGvigADYINANFINGeaPGTDKAYIASQGTMPDTVADFWQMIVEQNCRLVVMATNPVEKGKHKCTPYWPSSE-
.  |  ||| ||  .|  |  |    |      || |||..       . ....|| . .|.. |||. .   .  ... .  || | .||. |      
lkfkdlnrypniqcwdrgrftlag..de...nfyihanfvki..ctkperfvctqgplentcthfwqlalslgstsiillcgfvedgsekcakyisdivg

---R-RPARFGNYVVEL-LTEDNFDAYTVRRMSVAVG-EGDPREIYQYHYTSWPDHGVPPEREFLQ-LIMKIRqhRDRlrKsipglgPTLVHCSAGIGRT
         . .|. |. .     |  | | . | |   |.   . .| ..||||||.|   .  . |.  ..  .|.  |      | . |||||.|||
fvdledhrvyteycteieiggkskdkithrvlkvvvkatgqesklnhyqwaswpdhgmpdscdtalrllsavk..kdk..k......pviahcsagvgrt

GTFLVIDIVLDLIRHYGIDcdiDIQSIIHKLRGQRSGMI
||. .|. ..  .||   .   ... .   || .|.  .
gtlaliesmiaalrhprkq...nvkdsfvllrkdrarsv

subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 259-356 1.9e-20 67.5 In-house 45-155 (349) alignment
Range on Protein: 259-356
Range on HMM: 45-155/349.0
RIENKSKNRYKNILPYDHTRVKLRNVP-------------DGVIGADYINANFINGEAPGTDKAYIASQGTMPDTVADFWQMIVEQNCRLVVMATNPVEK
 .|  .|||||.||||.|.||||.. .             |. .  ||||||...     ..| ||| |  .| || ||...|. .. .||.  ..  |.
GvelfaknrykdilPyehsrvklkkslksskvikastsesdsgklddyinanylkltrisvekkyiatqaPlPstvddfykvillngvklvlsLnddkel

GKHKCTPYWPS
. .||  ||  
slekcdiywqe

subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 248-493 2.2e-20 67.3 In-house 22-274 (302) alignment
Range on Protein: 248-493
Range on HMM: 22-274/302.0
HQHKFDRMEGARIENK-SKNRYKNILPYDHTRVKLRNVPDGVIGADYI---NANFI--NGEAPGTDKAYIASQG-TMP--DTVADFWQMIVEQNCRLVVM
  .| ... .. .|.. |. | .  . . .|  || . ..  | |. .   . ..|  .|   ||.|    |.  ..|  .|.  .| .| . |  .|| 
aleklkkktstnlekdiserrkslficepktmaklvdfkndfinanvlkldeikwimaqGpmdGtekkekvskkpivpkkstlekhwalieqynvaivvq

ATNPVEKGKHKCTPYWPSSERRPARFGNYVVELLT----------EDNFDAYTVRRMSVAVGEGDPREIYQYHYTSWPDHGVPPEREFlqlIMKIRQHRD
 .. ||....||..|.    .   .||.| |. .             .|  |||      . .  .. .   ....||||| | | .     ..| .. .
lcsfvedeekkcaeyysdkvggelkfgrytvktvsvktdleeftdkksfklytveiknekkkkkvkktvdilafsawpdhGapkeayt...aldilkfce

RLRKSIpglgptLVHCSAGIGRTGTFLVIDIVLDLIRHYGIdcdIDIQSIIHKLRGQRSGMIQTA
  .|..      |||||||.|||||.. |   ..|  .  .    |. ||.  .|  | | .|..
sykknv......lvhcsaGvGrtGtlvaikyGiqlcskkkv...tdllsivlpvrqcryGavqde

subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 260-459 6.2e-20 66.0 In-house 45-233 (303) alignment
Range on Protein: 260-459
Range on HMM: 45-233/303.0
IENKSKNRYKNILPYDHTRVKLRNvpdgvigADYINANFINGEapgTDKAYIASQGTMPDTVADFWQMIVEQNCRLVVMATNPVEKGKHKCTPYWPSS--
..|  |||. ...  ||..||| .       . || |.... .   ..|  | .|  .. | |||||||.||. . |..     |  |      .|    
vknmdknrfvdvicldhskvklsd.......ssyihasyleld...sskkailtqlplshtaadfwqmiieqkvkcvlllltdseydklggdsvfprnqd

----ERRPARFGnyvvELLTEDNFDAYTVRRMSVAVGEGDpREIYQYHYTSWPDHGVPPEReFLQLIMKIRQHRDRLRKSIPGLgPTLVHCSAGIGRTGT
    | |  | |    |.   .  | .... .||. |.     .. .|| .||   .| .    ... .| | .  |||  ..  ||.    .| ||.||
flkfeersirvg....efkrvelgdgwvlkvlsvsngdyk.sflhvhhykawphnsipsdg.spkfvkqiwqlqsvlrkysdst.ptvymslsgcgragt

FLVIDI
| ... 
falfet

subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 280-493 1.7e-19 64.9 In-house 7-207 (255) alignment
Range on Protein: 280-493
Range on HMM: 7-207/255.0
KLRNVPDGVIGADYINANFINGEAPGTDKAYIAsqgtmpdTVADFWQMIVEQNCRLVVMATNPVEKGKHKCTPYWPSSERRPARFGNYVVELLTEDNFDA
|  ..|  .|  |    ..     .   . |.        ||. |.|.|| ..   ||| ..  |.|. ||  |.|       .. .  |      .   
kfkklPrilidedvctehvkPekdkkrknlysl.......tvdkfyqtivqtktevvvmlcdfaeegvekcssyfplekdeklkladvnvtttkssadvv

YTVRRMSVAVG-EGDPREIYQYHYTSWPDHGVPPEREFLQLIMKIRqhRDRlrKSIpglgptLVHCSAGIGRTGTFLVIDIVLD-LIRHY--GIDCDIDI
   ...   .|     ...  |.|. |...  | . . .. |.|.   ||   ||.      .||||.||||. .| ....|   .||        ..| 
lrtleitstlgekkkthtvkhysykGWieknaPelareilnilkvv..rds..ksv......vvhCstGiGrsaafvlaelvyqkmirsldttetveldy

QSIIHKLRGQRSGMIQTA
 |....|| .|.. |.| 
lslleelrskrkraihtP

subfamily_hpo-7_pd Subfamily hpo-7 279-493 6.9e-16 52.9 In-house 9-213 (263) alignment
Range on Protein: 279-493
Range on HMM: 9-213/263.0
VKLRNVPDGVIGADYInanfINGEAPGTDKAYIASQGTMPDTVADFWQMIVEQNCRLVVMATNPVEKGKHKCTPYWPSSERRPARFGNYVVELlTEDNFD
.|  ..|  .|  |       .. .|  ||   ...  . .|.. |.|.|| ..   ||| ..  |.|. ||  |.|       .. |  |   |.   |
lkfgklPrilidedvc....tehfkPekdkkrknlysllvqtidkfyqtivqtktevvvmLcDfneegvekcssyfPlekdekqklanvnvct.tkvqsd

AY-TVRRMSVAVG-EGDPREIYQYHYTSWPDHGVPPE-REFLQlIMKIRqhRDRlrKSIpglgptLVHCSAGIGRTGTFLVIDIVLD-LIRHY--GIDCD
     . .   .|     ... .| |. |...  | . || |. |.|.   |.   ||.       ||||.||||.  | |...|   .||        .
vllktlellstlgeKkkthtvkhysykgWiekndpelareiln.ilkva..rns..ksl......vvhcstGiGrsaafsvaElvyqkmirsldttstve

IDIQSIIHKLRGQRSGMIQTA
.|  |....|| .|.. |.| 
ldylsLleelrssrkraihtP

subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 228-495 7.7e-16 52.4 In-house 20-273 (302) alignment
Range on Protein: 228-495
Range on HMM: 20-273/302.0
EEEFGKAGFNEEFEQLQTMEHQhkFDRmEGARIENKSKNRYKNILPYDHTRVKLRNVPDgvigaDYINANFINgeAPGTDKAYIASQGTMPDTV---ADF
 ... .|  ..||....||  .   ..   |  .| .||. ...  .|...||| . ||     .|.||  ..   |   .  | .|    |..   ..|
vksldtaevkkefkkidtmkvd..lek.Ckafkknlkknqsedvpildsnlvkleaepd.....syvnaskve..vPeltrsiilaQlpkvdsedsveeF

WQMIVEQNCRLVVMATNPVEKGKhKCTPYWPSSERRPARFGNYVVEL-----LTEDNfDAYTVRRMSVAVGEGDPREIyqYHYTSWPDHGVPpeREFLQL
|.|. ....  ||..  . |  |     ..|        .|.  |         |.. ..|..  .   . .    ..  |. | |... ||   .. .|
Wrmvfqekivsvvilvgeeelkk.tlselfpkksgdykeygkmfvNnrkVekaeeek.tryviEvlPegcsnsvlanv..yvltnWkqkkvp..vkyael

IMKIRQHrdrLRKSIPGLGPTLVHCSAGIGRTGTFLVIDIVLDLIRHYgidCDIDIQSIIHKLRGQRSGMIQTAVC
| .. .      |.|..  .|..    |.|| |.||.  .... . .     .  |. |....| ||. .....  
iktaakv...fakkikadentvivSknGaGRagafltlavaveklqkg...kepnikeivksiRsqRpravdslkQ

subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 264-494 2e-15 51.7 In-house 21-246 (290) alignment
Range on Protein: 264-494
Range on HMM: 21-246/290.0
SKNRYKNILpYDHTRVKLRNVpDGVIGADYINANFINGeaPgTDKAYIASQ-------GTMPDTVADFWQMIVEQNCRLVVMATNPVEKGKH----KCTP
 ..|... |   .||| |..     .  ||| ||..    |  . . |..|        .   |. .|| |. . . . |||  .  || ..     |. 
mdqRlevpL.veatrvvLkgy.gkrfnddyiHAnrvtc..p.nglrliltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCak

YWPSSERRPARFGNYVVELLTEDNFDAYTVRRMSVAVGEGDPREIYQYHYTSWPDHGVPPE-REFLQLIMKIRQHRdrlrksipglGPTLVHCSAGIGRT
| | |.    .|..  |.     . |   .|.. |  ... .  .  . . .| .  |... . .|.||.|.....           | .|||  || | 
YvpesvgeelkfkgltvkCkskekeddvetRelvvkfddeeeftvtHsllkgWnklnvqedtktllsliqkvkask..........tpvivHcvdGiSrs

GTFLVIDIVLDLIRHygIDCDIDIQSIIHKLRGQRSGMIQTAV
 ..  |..   .| .     .. .......|| ||  .|..| 
AalaaiilgyQkiae..tsgsvkledvlkalrkqralaitsal

subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 394-494 2.3e-15 50.9 In-house 88-181 (440) alignment
Range on Protein: 394-494
Range on HMM: 88-181/440.0
PREIYQYHYTSWPDHGVPperEFLQLIMKIRQHRDRLRKsIPGLGPTLVHCSAGIGRTGTFLVIDIVLdliRHYGIDCDIDIQSIIHKLRGQRSGMIQTA
 | . |||| .|||.|||   .|   ..|. |  .  ..   | || ||||||| ||||  ...| .|   |.     .||| |.|  .| .|  |.|| 
srtlkqyhyqgwpdkgvp...kfagpvlkmiqdvnesqe.kagngpllvhcsagagrtgviiavdsil...reakrsdqidifsfinsmrnnrpqmvqtp

V
 
e

subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 384-493 1.7e-13 45.0 In-house 204-330 (350) alignment
Range on Protein: 384-493
Range on HMM: 204-330/350.0
RMSVAVGEGDPREIYQYHYTSWPDHGVPP-EREFLQLIM----KIRQHRDRLRKSIPGLGPTLVHCSAGIGRTGTFLVIDIVLD------LIRH--YGID
 ... .   || ..|| ..  |.| ..    ...|| .      | .   ..      . | |||||||.|||||.. .| .|        ...    .|
ltaitlaasdPyvvyqlqvknWkDlslllnPesilqalevkndliddlfaeshldnarsspilvhCsaGvGrtGtlvtlDsllsdfeilenltkesrkld

CD----IDIQSIIHKLRGQRSGMIQTA
        |. |. .|| ||  |.|. 
vaaktrDlisiivnelrkqrismvqnl

subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 260-302 6.8e-10 32.8 In-house 45-86 (440) alignment
Range on Protein: 260-302
Range on HMM: 45-86/440.0
IENKSKNRYKNILPYDHTRVKLRNVpDGVIGADYINANFINGE
 .|| ||||.||| |||.|| | .|  ||  .||||| .||| 
pnnkvknryrnilaydhsrvmleev.kgvpdsdyinasyingi

subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 286-417 1.2e-09 32.1 In-house 117-242 (244) alignment
Range on Protein: 286-417
Range on HMM: 117-242/244.0
DGVIGADYINANFINgeAPGTDKAYIASQGTMPDTVADFWQMIVEQNCRLVVMATnPVEKGKHkctpYWPSSERRPARFGNYVVELLTEDNFDAYTVRRM
 | .|  |||| |.     |    || .|  . ||  |||.|..|.   ..|.    ||.       ||| ||       .  | |   |.|       .
kgsmgntyinasfvg..clgrtaeyiltqhpladtsmdfwkmmlerhvnvlvvlg.sveeede....ywpdseplewyeeditvtltdrdefknikasnl

SVAVGEGDPR-EIYQYHYTSWPDHGVPPEREFL
 .     .    .  .  . ||  |  |.  |.
eiesdmneshqaltmfqisnwpsdgttpndhfi

subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 385-465 1.3e-09 31.8 In-house 208-293 (349) alignment
Range on Protein: 385-465
Range on HMM: 208-293/349.0
MSVAVGEGDPREIYQYHYTSWPDHGVPPE-REFLQLIM-K---IRQHRDRLRKSIPGLGPTLVHCSAGIGRTGTFLVIDIVLDLIR
 .. . . .| |..|  .  |.| ..  .   .|| .  |   | .   ||      | . ||||||| ||||..  .|..|... 
daillavekPyellqlqvknwldlslllnPisilqalevkndliddlfarlyldtdqlstllvhcsaGcGrtGvlvtldlllsile

subfamily_Sponge-PTP3_pd Subfamily Sponge-PTP3 255-315 1.7e-09 31.7 In-house 41-95 (95) alignment
Range on Protein: 255-315
Range on HMM: 41-95/95.0
MEGARIENKSKNRYKNILPYDHTRVKLRNVPDgvigADYINANFINGEApgTDKAYIASQG
  |.   |  |||. ||.||| ||| |    |    .||||| |..| |    ..|||.||
tvgsseanipknrflnifpydatrvvlttkrd....sdyinacfvdgya..rkncyiaaqg

0038934 (Phosphotyrosine protein) phosphatases II 396-458 3.5e-09 32.1 In-house 74-136 (194) alignment
Range on Protein: 396-458
Range on HMM: 74-136/194.0
EI----YQYHYTSWPDHGVPPEREFLQLIMKIRQHRDRLRKSipglGPTLVHCSAGIGRTGTFLVID
|.    ..|.   .||.|..|  | |. .... ..  .  ..    |  .||| ||.|||||...  
efekagieylklpfpddgtvPsleillrfldlvdeflnedpg....gvvaVHCkaGlgRtGtlvaaY

subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 238-302 9.3e-09 29.3 In-house 17-77 (244) alignment
Range on Protein: 238-302
Range on HMM: 17-77/244.0
EEFEQLqtMEHQHKFDRMEGARIENKSKNRYKNILPYDHTRVKLRNVPdgVIGADYINANFINGE
|||  |   .| ..| . .     | .|||| ||||.|.||| | .      |.||||||.|.| 
eefvgl..sdhtreflqtnavlsanatknryinilpfdetrvilsssk..kegsdyinanyiqgs

subfamily_Sponge-PTP-4_pd Subfamily Sponge-PTP-4 272-386 5.9e-08 27.1 In-house 3-101 (130) alignment
Range on Protein: 272-386
Range on HMM: 3-101/130.0
LPYDHTRVKlrnvpdgviGADYINANFINgeAPGTDKAYIASQGTMPDTVADFWQMIVEQNCRLVVMATNpVEKGKHkctpYWPSSERRPARFGNYVVEL
|... .|..         | .||||.|.     |  . |. .| .. ||  |||.|..|.   ..|.    ||.       ||| ||       . .| |
lefevsrlq.........gntyinasfvG..llgrtaeylltqhpladtsmdfwkmmleryvnvlvvlgs.veeede....ywpdsePlewyeediivtl

LTEDNFDAYTVRRMS
   |.|.      . 
tdrdefknikasnle

PTEN_1 397-454 6.7e-08 27.6 In-house 94-147 (196) alignment
Range on Protein: 397-454
Range on HMM: 94-147/196.0
IYQYHYTSWPDHGVPPEREFLQLIMKIRQHRDRLRKsipgLGPTLVHCSAGIGRTGTF
 ..|.  ...|||.|. .|..  . .. . . ....     .  |||| ||.||.|| 
gveylhfpieDhgapslselfdicksfiewllsdpn....gnvVlVHCkaGlgRsGtv

subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 262-342 8e-08 26.2 In-house 37-119 (347) alignment
Range on Protein: 262-342
Range on HMM: 37-119/347.0
NKSKNRYKNILPYDHTRVKLRNVPDGVIGA----DYINANFINGEApgTDKAYIASQGTMPDTVADFWQMIVEQNCRLVVMATNP
. |||| |.    | ||| |         |     ||||  |. .   ..| || .|  .|||| |||.|.   .   ||   .|
slsknrskdvklidatrvvlspeksknsraddvetyinashikfdn..askeyiltqyplpdtvrdfwkmvsvtkvtqvvtifep

subfamily_CG42327_pd Subfamily CG42327 437-493 2.6e-07 24.6 In-house 247-301 (319) alignment
Range on Protein: 437-493
Range on HMM: 247-301/319.0
LGPTLVHCSAGIGRTGTFLVIDIVLDLIRHYgiDCDIDIQSIIHKLRGQRSGMIQTA
 ||  |||| |.||||. .  || .  . .      .||  ... .| .|.  ..| 
qGPlvvhcsdGvGrtGlviasdiairslees..krsvdiPqlvssvrrdrasavltk

subfamily_Sponge-PTP-2_pd Subfamily Sponge-PTP-2 236-358 3.8e-07 23.2 In-house 5-88 (169) alignment
Range on Protein: 236-358
Range on HMM: 5-88/169.0
FNEEFEQLQTMEHQHKfdrmEGARIENKSKNRYKNILPYDHTRVKLRNVPDGvIGADYINAnfingeapgtdkayiasqgtmpdtvadfwQMIVEQNCRL
.||  | ..|.|..            |..|||    |   ||||||. | .  .|.|||||                             .|| | |  .
ynelkefmktieynnf....maeltcnetknrpagplapshtrvklqrvmed.lgsdyina.............................rmiwetnasv

VVMATNPVEKGKhkctpYWPSSE
.|.  .  .|       .||  |
ivvlgdtddknn.....fwpeke

subfamily_Sponge-PTP2_pd Subfamily Sponge-PTP2 236-358 5.5e-07 22.6 In-house 4-87 (169) alignment
Range on Protein: 236-358
Range on HMM: 4-87/169.0
FNEEFEQLQTMEHQHKfdrmEGARIENKSKNRYKNILPYDHTRVKLRNVPDGvIGADYINAnfingeapgtdkayiasqgtmpdtvadfwQMIVEQNCRL
.||  | ..|.|..            |..|||    |   ||||||. | .  .|.|||||                             .|| | |  .
ynelkefmktieynnf....maeltcnetknrpagplapshtrvklqrvmed.lgsdyina.............................rmiwetnasv

VVMATNPVEKGKhkctpYWPSSE
.|.  .  .|       .||  |
ivvlGdtddknn.....fwpeke

subfamily_Cele-PTP-12_pd Subfamily Cele-PTP-12 260-353 9.6e-07 22.6 In-house 32-120 (332) alignment
Range on Protein: 260-353
Range on HMM: 32-120/332.0
IENKSKNRYKNILPYDHTRVKLRNvPDGVigADYINANFINGEApgTDKAYIASQGTMPDTV-ADFWQMIVEQNCRLVVMATNPVEKGKHKcTPY
..|   ||   .  .||.||.|    ||    |. ||....| .     ||| .|  . |     ||.|. |..  ....  .  || |.| .||
lnnmdmnriphlycfdhsrvelap.qdgk..ddfynaswvdgys..kksayifaqapfndhteyvfwrmvserkpsmilvfgdidekqkrk.apy

subfamily_PTPDC1_pd Subfamily PTPDC1 395-493 2.7e-06 21.9 In-house 81-162 (182) alignment
Range on Protein: 395-493
Range on HMM: 81-162/182.0
REIYQYHYtSWPDHGVPPEREFLQLImKIRQHRdrLRKsipglGPTLVHCSAGIGRTGTFLVIDivldLIRHYgidcDIDIQSIIHKLRGQRSGMIQTA
..|| | . .|.|.||.. .. |... |. .    |..     | . ||| || ||||  .       |. .     ... .  |...| .|.  ||| 
qgiyvynf.gwkDygvasleriLdiv.kvvafa..lqe.....gkvavhChaGlGrtGvliacy....lvyak....rltaekaiklvrskrpksiqtr

subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 307-386 3.1e-06 20.8 In-house 235-310 (440) alignment
Range on Protein: 307-386
Range on HMM: 235-310/440.0
DKAYIASQGTMPDTVADFWQMIVEQNCRLVVMATNPVEKgkhKCTPYWPSSErRPARFGNYVVELLTEDNFDAYTVRRMS
 .|.||.|  .  || |||... . .   ..|  .  .|    |. |||    |   || . |     .|..   || . 
knafiatqmpldstvldfwrlvhdyristiimlnqlndk...tcsiywpvnt.rsvtfgpftvghkgsenmnrvkvrtle