Gene PTPRD in Monosiga brevicollis

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily PTPRD
Protein sequence
ID Type Fasta BLAST phosphatome Note
MbreP069_AA protein Get Run
MbreP069_AA_3399-3676 phosphatase_domain Get Run
MbreP069_AA_3688-3991 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_PTPRD_pd Subfamily PTPRD 1255-1574 7.5e-132 435.8 In-house 2-320 (564) alignment 
Range on Protein: 1255-1574
Range on HMM: 2-320/564.0
RHEISVSDLNTVIQQMAANSDFAFSEEYECIESGSEFGRNYAIMDRNRQKNRFANILAYDHSRVPLHKLPNDPYSDYINANYIDGYNQPKSYIAAQGPLP
...|.|..|.. .... ||||. |.|||..||.|..|  . | .. |..|||.|||.||||||| |.|...|. ||||||..||||...|.|||.||||.
skpipvaelkehvaklkansdlkfeeeykkieegqqftweaankpaNkaKNRyanivaYdhsRVvLskvegdegsDYINAsfidgyrkrkayIAtqgPla

HTLMDFWRMIWEQRVSVIVMVTNLEEKGRTKCHRYWPEEvGgQLPLtTNMSVFMTKQEEFPDMVIRHLTV--QVSQQSRVVTQFHYISWPDHGVPDSTAG
.|..|||||.|||..|.|||.|.|||||..|||.||||. | .     .. | ....||. |..||....  . |..|| |.|||..||||||||.|...
etiedFWRmvweqnsstiVmltkleEkgkvkchkYWPek.g.tety.geltVtleeeeeladyeirtfklkkkkssesreVrqFhFtsWPdhgvpesats

ILTTIRRAKETRnQAAAGPMVVHCSAGVGRTGTLIAIDYNLDKAASENKVDVMGSLNEMRRQRTTMVQTEGQYIFIYRALADGLSNIVTEMSPETLRKHF
.|. ||. .... .  |||.||||||||||||| |.||. |... .|..||... ....|.|| .||||| |||||..|... |.  .||.. |.|..|.
lLdlirkvraln.epdagPivVhCSaGVGRTGtfividamlerikeektvDiyqyvkalrkqRnamVqteeQYiFiheailealacgntevesenlkqhl

DELRKPVSS-GGTQLDQEFRGLS
..|.. ..  . |.|..||. |.
qkLaeveedtemtgleleFqrLa
subfamily_PTPRD_pd Subfamily PTPRD 1562-1857 5.1e-120 396.8 In-house 21-287 (564) alignment 
Range on Protein: 1562-1857
Range on HMM: 21-287/564.0
GGTQLDQEFRGLSQGppsSNTRTDAAQQMANKSKNRFQNIMPYDASRVKLSALPGVVGSDYINASYIDGFRQRKQFIATQGPMQSTLADFWRMVWEQEVH
.......|.. ...|   ......||.. |||.|||..||..||.|||.||...|. ||||||||.|||.|.||..||||||...|..|||||||||...
sdlkfeeeykkieeg...qqftweaankpaNkaKNRyanivaYdhsRVvLskvegdegsDYINAsfidgyrkrkayIAtqgPlaetiedFWRmvweqnss

SIVMLTHLEESGRQKSEQYWPSLgSdPLNVGDLQVSISEEEHKSFGVERTLTLLNPVSDQAREVKHWQFPNWPSSGEMGSGRDLVDLVMRVEDYARskvv
.|||||.|||.|..| ..|||.  . . ..|.|.|...|||...  . ||..| .  |...|||....| .||..| . |...|.||...|.....    
tiVmltkleEkgkvkchkYWPek.g.tetygeltVtleeeeeladyeirtfklkkkkssesreVrqFhFtsWPdhgvpesatslLdlirkvralne....

vpqeesiygnreainehailQQLKPTVVHCSAGVGRTGAYCAAVICLERMKQENKVDLYQVTKHLRTQRPGMVQTAEQYAFVYRVILDYLDKQNGA
                    .. .|.||||||||||||....  ..|||.|.|..||.||. |.||.||. |||| |||.|....||..|...|  
....................pdagPivVhCSaGVGRTGtfividamlerikeektvDiyqyvkalrkqRnamVqteeQYiFiheailealacgnte
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 1257-1571 5e-109 359.2 In-house 1-316 (318) alignment 
Range on Protein: 1257-1571
Range on HMM: 1-316/318.0
EISVSDLNTVIQQMAANSDFAFSEEYECI-ESGSEFGRNYAIMDRNRQKNRFANILAYDHSRVPLHKLPNDPYSDYINANYIDGYNQPKSYIAAQGPLPH
||||.||.. .... .. .  .||||| .  | ... .  .. . |..|||.||||||||.|| |..| ... ||||||||||||.. |.|||||.|||.
eisvedleshvrrlresGelllseeyerlsrseetvtslkslepvnkaknryanilaydhtrvkLqmlegeegsDyinanyidGyrrkkayiaaqaPlpe

TLMDFWRMIWEQRVSVIVMVTNLEEKGRTKCHRYWPEEvggQLPLTTNMSVFMTKQEEFPDMVIRHLTVQV--SQQSRVVTQFHYISWPDHGVPDSTAGI
|. |||||.|||  .||||.|..||.|..|.|||||..   .     .. | .... |. |.|.|...|.   ...||.| |.|| ||||.|||.|.|..
tieDfWrmvWeqnsavivmltqeeergkakvhryWPsk...gsrsygklvvelkeevelsdyvlrefkvtrteeeesrqvrqyhytsWpdegvpesgasl

LTTIRRAKETRNQAAAGPMVVHCSAGVGRTGTLIAIDYNLDKAASENKVDVMGSLNEMRRQRTTMVQTEGQYIFIYRALADGLSNIVTEMSPETLRKHFD
|  .|..... ... |||.||||||||||||. ||.|  |.... |. |||..  ...|.||  ||||| ||.||| .| . |    ||.. . ||..  
ldlvrqvskaqqksgagpivvhCsaGvGrtGvfiavdillerikaealvDvfqtvkqlreqrnlmvqtedqyefiydvllealasgdtevdasdlrsrir

ELRKPV-SSGGTQLDQEFR
|||..   || |..| ||.
elreqdpesgttemdaefq
subfamily_PTPRB_pd Subfamily PTPRB 1256-1537 5.8e-104 342.2 In-house 5-286 (293) alignment 
Range on Protein: 1256-1537
Range on HMM: 5-286/293.0
HEISVSDLNTVIQQMAANSDFAFSEEYECIES-GSEFGRNYAIMDRNRQKNRFANILAYDHSRVPLHKLPNDPYSDYINANYIDGYNQPKSYIAAQGPLP
..|....... ...|.|.||. |||||| ... |..   . |   .||.|||. |||.|||||| |..| ... |||||||||.|||.|. .||.|||||
kpiklekfeehvkkmkadsdlrfseeyeelkavgkdqavkaaelavnraknrytnilpydhsrvkLaalkdesgsDYinanyipgynsprefiatqGPlp

HTLMDFWRMIWEQRVSVIVMVTNLEEKGRTKCHRYWPEEVGGQlpLTTNMSVFMTKQEEFPDMVIRHLTVQVSQQSRVVTQFHYISWPDHGVPDSTAGIL
.|. |||||.||...|.|||.|.| |||..||..|||..   .  |  ...| ....||  | |||.|... ....| |.|.|..||||||||..|. .|
etvddfWrmvwekkssiivmltqlvekgkvkCeeYWPadeepv..lyGdikvtlvaeeeledwvirelkiekekeerkvrqyhftsWpdhgvPektktll

TTIRRAKETR-NQAAAGPMVVHCSAGVGRTGTLIAIDYNLDKAASENKVDVMGSLNEMRRQRTTMVQTEGQYIFIYRALADGLS
. .|. .|.  ..|...|.|||||||||||||.||.|  |..  .|. ||..| . |.|..|...|||| |||||.... | |.
dfvrtvreaiektaskrPivvhCsaGvGRtGtfialdrllqaieeedyvdifgivaelReeRnllvqtekqYifihqcvldllr
0051299 (Phosphotyrosine protein) phosphatases II 1256-1534 1.1e-97 322.3 In-house 3-284 (288) alignment 
Range on Protein: 1256-1534
Range on HMM: 3-284/288.0
HEISVSDLNTVIQQMAANSDFAFSEEYECIESGSEFGR-NYAIMDRNRQKNRFANILAYDHSRVPLHKLPNDPYSDYINANYIDGYNQPKSYIAAQGPLP
.||||..|  ..... ||.   . ||.| . |  . .  ..|..  |..|||. .||.|||||| |. |.... ||||||.||||||... .||.|||||
teisveellklvlkllangltglleefeellsllpdltlsaallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyidgynlkrkfIatqgPlp

HTLMDFWRMIWEQRVSVIVMVTNLEEKGRTKCHRYWPEevgGQLPLTTNMSVFMTKQEEFPDMVIRHLTVQ------VSQQSRVVTQFHYISWPDHGVPD
.|. |||||.|||.|.||||.|.|.|.||.||..|||.   |.     ...| ... |...|...|.|.|.       ...|| ||.|||..||||||||
ntvedFWrmvweqnvrvIvmltklvelgrekcaqYwpl...ggsltygditvtllseevlddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpd

STAGILTTIRRAKETRNqAAAGPMVVHCSAGVGRTGTLIAIDYNLDKAASENKVDVMGSLNEMRRQRTTMVQTEGQYIFIYRALAD
|.  .|. .|.... .. .  ||.|||||||||||||.||.|. |.    |..|||.. .. .|.||  ||||. ||.|.|.||..
spellldflrlvrkala.sgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtpeqyrfvyealle
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 1255-1570 1.2e-96 318.6 In-house 2-318 (319) alignment 
Range on Protein: 1255-1570
Range on HMM: 2-318/319.0
RHEISVSDLNTVIQQMAANSDFAFSEEYECIESGSEFGRNYAIMDRNRQKNRFANILAYDHSRVPLHKLPNDPYSDYINANYIDGYNQPKSYIAAQGPLP
. || | .|.. ....|....  . .|..... ....  . | ...|..|||. ||||||..|| | .|.. . ||||||..||||.. . .||.|.|| 
dteievqeLkerlkalastgetllekefkllkeavndtfdsaskeenkkknryqnilaydrtrvvlseldgvegsdyinasfidgyqerekfiatqaPle

HTLMDFWRMIWEQRVSVIVMVTNLEEKGRTKCHRYWPEEVGGQlplTTNMSVFMTKQEEFPDMVIRHLTVQVS-QQ--SRVVTQFHYISWPDHGVPDSTA
.|. |||||.||...|..||.|.| ||.. |...|||||   .     .. | . ..||  |..||.|...   ..  .| |..|.| .||||.||... 
ntiedfWrmvWeeessivvmltklveklkvklkkywpeenfee...yGrlivtleeeeeledyiirklklnkkssevetRevkhfqyteWpdhdvPekat

GILTTIRRAKETRNQAAAGPMVVHCSAGVGRTGTLIAIDYNLDKAASENKVDVMGSLNEMRRQRTTMVQTEGQYIFIYRALADGLSNIVTEMSPETLRKH
..|  ..| ...|..  .||.||||||||||||| |..|  |..   |. .||    ...| || .|||.. ||.||| || . ..   ||.  . ||. 
slldllkrirksrektqsgPivvhCsaGvGRtGtfivldamlervkeegvlDvfstvsrlRtqRnimvqrpeqYkfiyealleaveagdteievqdlrdr

FDELRKPV-SSGGTQLDQEF
. .|.. |  .| |.|..||
lkqlaekvadtgetgleref
0050432 (Phosphotyrosine protein) phosphatases II 1256-1541 1.7e-96 318.5 In-house 24-304 (308) alignment 
Range on Protein: 1256-1541
Range on HMM: 24-304/308.0
HEISVSDLNTVIQQmaANSDFAFSEEYECIESGSEFGR-NYAIMDRNRQKNRFANILAYDHSRVPLhklpnDPYSDYINANYIDGY--NQPKSYIAAQGP
...|| ||   ...  |..   ..||.| . |  . .  ..| . .|. |||. .||.|||||| |     |. ||||||.|.|||  ..|. .||.|||
lklsvldllkllek..aldlglleeefeellsvkplleysvallpenkdkNrykdilpydhsRVkl.....degsdYInAsyvdgyssklprkfIatqgP

LPHTLMDFWRMIWEQRVSVIVMVTNLEEKGRTKCHRYWPEEVGGQLPLTTNMSVFMTKQEEFPDMVIRHLTVQV--SQQSRVVTQFHYISWPDHGVPDST
||.|. |||||.|||.|.||||.|.|.|.|| ||..|||.|.||.     ...| ....|...|...|.|...   ...||.||.|||..|||||||.|.
lpntvedFwrmvweqnvrvIvmLtklvengrekcaqYwplelgggsleygkftvtllseevlddytvrtleltnlgdgesrtvthfhytnWpdhgvPpsp

AGILTTIRRAKETRNQaaaGPMVVHCSAGVGRTGTLIAIDYNLDKAASENKVDVMGSLNEMRRQRTTMVQTEGQYIFIYRALADGLSNIVT
. .|. ..........   ||.|||||||||||||.||.|. |.    |..||| . .. .|.||  ||||. ||.|.||||.. |....|
eilldflelvrkslpg...gpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtpeqylflyralleylklklt
0040438 (Phosphotyrosine protein) phosphatases II 1261-1556 4.5e-95 313.8 In-house 3-296 (317) alignment 
Range on Protein: 1261-1556
Range on HMM: 3-296/317.0
SDLNTVIQQMAANSDFAFSEEYECIESGSEFGRNYAIMDRNRQKNRFANILAYDHSRVPLHKLPNDPYSDYINANYIDGYNQPKSYIAAQGPLPHTLMDF
 ||. ..... ...  |..||.| . | .   ...|..  |..|||. .|| |||||| |. |..|. ||||||.|.||.|... .||.|||||.|. ||
ldlllalldllksdftalleefedllslkldtysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyvdgpnlkrkfIatqgPlpntvedF

WRMIWEQRVSVIVMVTNLEEKGRTKCHRYWPEevgGQLPLTTNMSVFMTKQEEFPDMVIRHLTVQ--VSQQSRVVTQFHYISWPDHGVPDSTAGILTTIR
|||.|||.|.||||.|.|||.|| ||..|||.   |.     ...| ... || .....|.|.|.   ...|| ||.|||..|||||||.|.  .|  ..
wrmvweqgvtvivmLteleelgrekcaqYwpl...getltygdftvtllseeelagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfle

RAKETRNqAAAGPMVVHCSAGVGRTGTLIAIDYNLDKAASENKVDVMGSLNEMRRQRTTMVQTEGQYIFIYRALADGLSNIVTEMSPETLRKHFDELR
...| ..    ||..||||||||||||.||... |.    |..|||   ..|.|.||  .|||..||.|.|.||.. | . .|  .   | .....| 
avreale.dpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalleylkrkltlepaselklkllkll
0046845 (Phosphotyrosine protein) phosphatases II 1278-1540 1.3e-93 308.8 In-house 2-278 (284) alignment 
Range on Protein: 1278-1540
Range on HMM: 2-278/284.0
FSEEYECIESGSEF---GRNYAIMDRNRQKNRFANILAYDHSRVPLHKLPND-PYSDYINANYIDGY-----NQPKSYIAAQGPLPHTLMDFWRMIWEQR
. ||.| . |   .    ...|..  |. |||. .||.|||||| |. |..| . ||||||.|.|||     ...| .||.|||||.|. |||||.|||.
leeefeellsltvklllslsvallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweqn

VSVIVMVTNLEEKGRTKCHRYWPEEvgGQLPLTTNMSVFMTKQEEFPDMVIRHLTVQV---SQQSRVVTQFHYISWPDHGVPDSTAGILTTIRRAKETRN
|.||||.|.|.|.||.||..|||.|  |.     ...| ... |...|...|.|...    ...|| ||.|||.||||||||.|.. .|. .| ..| ..
vrvIVmltelvengrekcaqYwple..gevltygdftvtllseevkddytvrtleltnlgytgesrtvthfhytswpdhgvppspedlleflrlvrelle

Q-AAAGPMVVHCSAGVGRTGTLIAIDYNLDKAASEN---KVDVMGSLNEMRRQRTTMVQTEGQYIFIYRALADGLSNIV
.    ||.|||||||||||||.||.|. |.    |.   .||| . .. .|.||  ||||. ||.|.|.||.. |....
nlpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyealleylklkl
subfamily_PTPRG_pd Subfamily PTPRG 1258-1550 9.9e-93 306.2 In-house 1-301 (563) alignment 
Range on Protein: 1258-1550
Range on HMM: 1-301/563.0
ISVSDLNTVIQQMAANSDFAFSEEYECIESG---SEFGRNYAIMDRNRQKNRFANILAYDHSRVPLHKLPNDPYS-DYINANYIDGYNQPKSYIAAQGPL
. |....  . .. |..|  ||||.| ..|    ...  . .    |..|||  ||.|||.||| |..||.   . |||||||||||.. | .||.||||
vpvkefakhvaslhadgdigfseefealqsetiskdldaehsqkpenkrKnRylnivaydrsRvklsplpgkkkklDYinAnyidGyqkskafiatqgpl

PHTLMDFWRMIWEQRVSVIVMVTNLEEKGRTKCHRYWPEEVG---GQLPLTTNMSVFMTkQEEFPDMVIRHLTVQVSQQ---SRVVTQFHYISWPDHGVP
..|. |||||||||.|..|||.|||.|.|| ||..|||..     |.| .|   .  ..       .||..| ..  .|    ..|.|.|| .|||||||
kdtfddFWrmiWeqnvaiivmitnlvergrrkcdvYWPkdesetygalqvtlieeevla.lytvrtlviknlklkkkkqcdteklvrqyhytkWPdhgvP

DSTAGILTTIRRAkETRNQAAAGPMVVHCSAGVGRTGTLIAIDYNLDKAASENKVDVMGSLNEMRRQRTTMVQTEGQYIFIYRALADGLSNIVTEMSPET
....  |. .... .. |.|.|||.|||||||||||||.|..|  | .  .||.|.| | |  .| ||  .|||| ||||.. || . ..   ||.. | 
ehslpvLifvkks.saankaeaGPivvHcsaGvgrtGtyivldtllkqiqqenavnvfgflkhiraqRnflvqteEqYiflhdalleaiasketellaeq

LRK
...
vee
0051299 (Phosphotyrosine protein) phosphatases II 1546-1851 2.9e-92 304.5 In-house 8-286 (288) alignment 
Range on Protein: 1546-1851
Range on HMM: 8-286/288.0
ETLRKHFDELRkpvSSGGTQLDQEFRGLSQGPPSsnTRTDAAQQMANKSKNRFQNIMPYDASRVKLSALPGVVGSDYINASYIDGFRQRKQFIATQGPMQ
| |.|.. .|.    .| |.| .||. | .  |.    . ||.  .|..|||...|.||| |||||| |.|| ||||||||||||... ..|||||||..
eellklvlkll...angltglleefeellsllpd..ltlsaallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyidgynlkrkfIatqgPlp

STLADFWRMVWEQEVHSIVMLTHLEESGRQKSEQYWPSlgSDPLNVGDLQVSISEEEHKSFGVERTLTLLNP----VSDQAREVKHWQFPNWPSSGEMGS
.|..|||||||||.|. ||||| |.| ||.|..||||.  ...|..||..| . .||...  . |||.. |      ... |.|.|....|||  |   |
ntvedFWrmvweqnvrvIvmltklvelgrekcaqYwpl..ggsltygditvtllseevlddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpds

GRDLVDLVMRVEDYARskvvvpqeesiygnreainehailQQLKPTVVHCSAGVGRTGAYCAAVICLERMKQENKVDLYQVTKHLRTQRPGMVQTAEQYA
 ..|.|....| .. .                        .. .|.||||||||||||...|. ..||....|..||.... |.||.|||||||| ||| 
pellldflrlvrkala........................sgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtpeqyr

FVYRVILDYL
|||...|.||
fvyealleyl
0039614 (Phosphotyrosine protein) phosphatases II 1256-1539 1.4e-91 302.3 In-house 12-292 (297) alignment 
Range on Protein: 1256-1539
Range on HMM: 12-292/297.0
HEISVSDLNTVIQQMAANSDFAFSEEYECIESGSEfGRNYAIMDRNRQKNRFANILAYDHSRVPLHKLPN-DPYSDYINANYIDGYNQ-PKSYIAAQGPL
  |..| |. ... . |||   . .|.| . |  .  . .|    |. |||. .||.|||||| |. ... |. ||||||.|.|||.. .. .||.||||
ipiplsvldlllllekansktllllefeellslkp.dysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfIatqgPl

PHTLMDFWRMIWEQRVSVIVMVTNLEEKGRtKCHRYWPEEVGgqlpLTTNMSVFMTKQEEFPDMVIRHLTVQVSQQSRVVTQFHYISWPDHGVPDSTAGI
|.|. |||||.|||.|.||||.|.|.|.|| ||..|||||.|       ...| ..| |. .....|.|.|. ...|| ||.|.|..|||||||.|.. .
petvedFwrmvweqgvtvivmLtklvelgr.kcaqywpeegg....tygdftvtllkvehldgytvrtlevtnngesrtvthfqytgwpdhgvppslell

LTTIRRAKETRNQA-AAGPMVVHCSAGVGRTGTLIAIDYNLDKAASENKVDVMGSLNEMRRQRTTMVQTEGQYIFIYRALADGLSNI
|  .. ..| ....   ||..||||||||||||.||... |.   .| .|||   ..|.|.||  .|||..||.|.|.||.. |...
leflelvrealaelpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydallellkrk
0036941 (Phosphotyrosine protein) phosphatases II 1278-1548 1.8e-91 301.9 In-house 15-289 (297) alignment 
Range on Protein: 1278-1548
Range on HMM: 15-289/297.0
FSEEYECIESGSEFGR-NYAIMDRNRQKNRFANILAYDHSRVPLhklpNDPYSDYINANYIDGYNQPKSYIAAQGPLPHTLMDFWRMIWEQRVSVIVMVT
...|.| . .    |  ..|.  .|..|||. .||.|||.|| |    .|. ||||||.|.|||.... .||.|||||.|. |||||.|||.|.||||.|
llkefeellpllllgslsvallpenleknRykdilpydhtRVkl....ddegsdYinAsyvdgydlkrkfIatqgPlpntvedFWrmvweqnvtvIvmlt

NLEEKGRTKCHRYWPEEVGGQLPLtTNMSVFMTKQEE--FPDMVIRHLTVQV--SQQSRVVTQFHYISWPDHGVPDSTAGILTTIRRAKETRNQA-AAGP
.|.|.|| ||..|||.|.|. |    ...|.... |.  ..|...|.|.|.   ...||.||.|||..|||||||.|.| .|  |..... ....   ||
elvelgrekcaqywpleegeslty.gdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfielvrkvlkllpsggp

MVVHCSAGVGRTGTLIAIDYNLDKAA---SENKVDVMGSLNEMRRQRTTMVQTEGQYIFIYRALADGLSNIVTEMSPETL
..|||||||||.||.||.|. |.       |..||.   ....|.||  .|||..||.|.|.||.. | .. | ...  |
vlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallellkkkltkepllkl
0047943 (Phosphotyrosine protein) phosphatases II 1273-1533 1.2e-90 299.0 In-house 9-269 (273) alignment 
Range on Protein: 1273-1533
Range on HMM: 9-269/273.0
NSDFAFSEEYECIESGSEFGR-NYAIMDRNRQKNRFANILAYDHSRVPLhklpNDPYSDYINANYIDGYNQPKSYIAAQGPLPHTLMDFWRMIWEQRVSV
..   . ||.| . |  . .  ..|.. .|..|||. .||.|||||| |    .|. ||||||.|.||||... .||.|||||.|. |||||.|||.|.|
lgltllleefelllslkplltysvallpenkdknrykdilpydhsrvkl....gdggsdyinAsyvdgynlkrkfiatqgPlpntvedfwrmvweqnvrv

IVMVTNLEEKGRTKCHRYWPEEVGGQLPLTTNMSVFMTKQEEFPDMVIRHLTVQV--SQQSRVVTQFHYISWPDHGVPDSTAGILTTIRRAKETRNQA-A
|||.|.|.|.|| ||..|||.|.|.      ...| ....|...|...|.|...   ...||.||.||| .|||||||.|.. .|. |. ........  
iVmLtelvelgrekcaqYwpleggelsltygkftvtllseetkddytvrtleltnlgtgesrtvthfhytgwpdhgvppslesllefielvrkalealps

AGPMVVHCSAGVGRTGTLIAIDYNLDKAASENKVDVMGSLNEMRRQRTTMVQTEGQYIFIYRALA
 ||.|||||||||||||.||.|. ||    |..|||   .. .|.||  ||||. ||.|.|.||.
ngpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrflyeall
0050432 (Phosphotyrosine protein) phosphatases II 1557-1853 3e-90 298.0 In-house 37-301 (308) alignment 
Range on Protein: 1557-1853
Range on HMM: 37-301/308.0
KpvSSGGTQLDQEFRGLSQGPPssNTRTDAAQQMANKSKNRFQNIMPYDASRVKLsalpGvVGSDYINASYIDGF--RQRKQFIATQGPMQSTLADFWRM
|    . ..|..||. | . .|  .  ...|.. .||.|||. .|.||| |||||    .  |||||||||.||.  .....|||||||...|..|||||
k..aldlglleeefeellsvkp..lleysvallpenkdkNrykdilpydhsRVkl....d.egsdYInAsyvdgyssklprkfIatqgPlpntvedFwrm

VWEQEVHSIVMLTHLEESGRQKSEQYWPSLGS-DPLNVGDLQVSISEEEHKSFGVERTLTLLNPVSDQAREVKHWQFPNWPSSGEMGSGRDLVDLVMRVE
||||.|. ||||| |.| ||.| .||||.    ..|..|...| . .||...  . |||.| |  ... |.|.|....|||  |   | ..|.|.. .|.
vweqnvrvIvmLtklvengrekcaqYwplelgggsleygkftvtllseevlddytvrtleltnlgdgesrtvthfhytnWpdhgvPpspeilldflelvr

DYARSkvvvpqeesiygnreainehailqqlKPTVVHCSAGVGRTGAYCAAVICLERMKQENKVDLYQVTKHLRTQRPGMVQTAEQYAFVYRVILDYLDK
.. ..                          .|.||||||||||||...|. ..||....|..||.... |.||.|||||||| ||| |.||..|.|| .
kslpg..........................gpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtpeqylflyralleylkl
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 1263-1538 3.1e-90 297.1 In-house 2-278 (281) alignment 
Range on Protein: 1263-1538
Range on HMM: 2-278/281.0
LNTVIQQMAANSDFAFSEEYECIES-GSEFGRNYAIMDRNRQKNRFANILAYDHSRVPLHKLPNDPYSDYINANYIDGYNQPKSYIAAQGPLPHTLMDFW
|.. ..|. .|..  | |||| ... | .   . .  | |..|||. || |||..|| ...  ..  .||||||...||...| |||.|||.|..|..||
lrkhlkqlsqndnaGfieeyeklaaigvdntataskadenvlknrYsnivaYDatrvkvtpneenkntDYinanfvpgykgekeyiatqgPvPaslvafW

RMIWEQRVSVIVMVTNLEEKGRTKCHRYWPEEVGgQLPlTTNMSVFMTKQEEFPDMVIRHLTV-QVSQQSRVVTQFHYISWPDHGVPDSTAGILTTIRRA
.|.|||.||.|||||.  |.|. |||||||..   .|   ... | .|..|| . .. |.... . | ..| |.|..|..|||||||..|. .|   .  
qmvweqkvsaivmvtreieagklkChrYWPddns.elk.ygdvtvkstaeeekatyierkfkleresgetreveqlaytaWPdhGvPattkellefrkev

KETRNQAAAGPMVVHCSAGVGRTGTLIAIDYNLDKAASE-NKVDVMGSLNEMRRQRTTMVQTEGQYIFIYRALADGLSN
......    |.|.||||||||||| ||.|  ......| ...||   ..|.|..|. ||||  || |.|.|. | |..
lkltekktkaplvihCsaGvGrtGtyialDrlvkaveaeleeldvkavvaelrkernlmvqtvvqyefvykavldaldk
subfamily_PTPRA_pd Subfamily PTPRA 1257-1559 5.8e-90 296.5 In-house 13-318 (330) alignment 
Range on Protein: 1257-1559
Range on HMM: 13-318/330.0
EISVSDLNTVIQQMAANSDFAFSEEYECIESGSEFG-RNYAIMDRNRQKNRFANILAYDHSRVPLHKLPNDPYSDYINANYIDGYNQPKSYIAAQGPLPH
 . | .|.  |.. .|.    | ||.... .|.  .  . |  . |..|||. ||| ||.||| | ..   ..|||||| .||||.. ...||||||. .
plpvekleeeirirsaddnklfreefnalPagpiqatlelaskeenkeknrvvnilPydfsrvilsvkeGveesdyinasfidGykekdkfiaaqGPkee

TLMDFWRMIWEQRVSVIVMVTNLEEKGRTKCHRYWPEEvgGQLpLTTNMSVFMTKQEEFPDMVIRHLTVQ------VSQQSRVVTQFHYISWPDHGVPDS
|. |||||||||. . |||.|.|.|. ..||..|||.|  | .    |. | . ....  |. .|.. ||        ..||.|.|||. |||| |||  
tvedfwrmiweqksativmltelkerkeekcaqywPde..Glv.tyGnirvevedetvlvdytvrkflvqqlpdatrekksrlvrqfhftswPdvGvPfe

TAGILTTIRRAKETRNQaAAGPMVVHCSAGVGRTGTLIAIDYNLDKAASENKVDVMGSLNEMRRQRTTMVQTEGQYIFIYRALADGLSNIVTEMSPETLR
. |.|  ... |....|  |||.|||||||||||||.|..|  |..  .|.|||| . ....| ||. ||||. || |||..| .      ||.   .| 
piGmlkllkkvkklnqq.sagpivvhcsaGvGrtGtfivldavlervkaerkvdvfefvkrlrlqrpqmvqtdeqyefiykvlleyylygdteldvssle

KHFDELRKPV
||...| . .
khlqklynki
DSPc_SM00195 1281-1534 7.6e-90 296.1 In-house 5-260 (263) alignment 
Range on Protein: 1281-1534
Range on HMM: 5-260/263.0
EYECIESGS-EFGRNYAIMDRNRQKNRFANILAYDHSRVPLHKLPNDPYSDYINANYIDGYNQPKSYIAAQGPLPHTLMDFWRMIWEQRVSVIVMVTNLE
|.| .|.   .   . |. ..|..|||. ||| |||.|| |.| .... |||||||||.|.|..|.|||.|||||.|. |||||.||..|..|||.|. |
efekleestspketteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlteee

EKGRTKCHRYWPEEVGGQLPLTtNMSVFMTKQEEFP-DMVIRHLTVQVSQ--QSRVVTQFHYISWPDHGVPDSTAGILTTIRRAKETRNQAaAGPMVVHC
|.|..||.|||||| ||.   . ..|| ....|. . ....|.|...  .  ..| |||..| .||||||||||  .|  .| .|.....   ||.||||
engkekcdrywpeesggketfg.kisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkksksts.sgpivVhC

SAGVGRTGTLIAIDYNLDKAASENKVDVMGSLNEMRRQRTTMVQTEGQYIFIYRALAD
|||||||||...||. |.| ..|.|||.   ..|.| ||  ||||. ||.|||.|...
saGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaile
PTPc_SM00194 1281-1534 7.6e-90 296.1 In-house 5-260 (263) alignment 
Range on Protein: 1281-1534
Range on HMM: 5-260/263.0
EYECIESGS-EFGRNYAIMDRNRQKNRFANILAYDHSRVPLHKLPNDPYSDYINANYIDGYNQPKSYIAAQGPLPHTLMDFWRMIWEQRVSVIVMVTNLE
|.| .|.   .   . |. ..|..|||. ||| |||.|| |.| .... |||||||||.|.|..|.|||.|||||.|. |||||.||..|..|||.|. |
efekleestspketteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlteee

EKGRTKCHRYWPEEVGGQLPLTtNMSVFMTKQEEFP-DMVIRHLTVQVSQ--QSRVVTQFHYISWPDHGVPDSTAGILTTIRRAKETRNQAaAGPMVVHC
|.|..||.|||||| ||.   . ..|| ....|. . ....|.|...  .  ..| |||..| .||||||||||  .|  .| .|.....   ||.||||
engkekcdrywpeesggketfg.kisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkksksts.sgpivVhC

SAGVGRTGTLIAIDYNLDKAASENKVDVMGSLNEMRRQRTTMVQTEGQYIFIYRALAD
|||||||||...||. |.| ..|.|||.   ..|.| ||  ||||. ||.|||.|...
saGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaile
0043336 (Phosphotyrosine protein) phosphatases II 1258-1533 2.7e-89 294.6 In-house 2-274 (278) alignment 
Range on Protein: 1258-1533
Range on HMM: 2-274/278.0
ISVSDLNTVIQQMAANSDFAFSEEYECIESGSEFGRNYAIMDRNRQKNRFANILAYDHSRVPLHKLPNDPYSDYINANYIDGYNQPKSYIAAQGPLPHTL
|||.||   .... .|.  ....|.| . |   . ...|.   |..|||. .||.|||||| |. |..|. ||||||.|.||||.|. .||.|||||.|.
isvkdllkallelllnlktllllefeellsfkldtysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyvdgynvprkfiatqgPlpetv

MDFWRMIWEQRVSVIVMVTNLEEKGRTKCHRYWPeevgGQLPLTTNMSVFMTKQEEFPDMVIRHLTVQ--VSQQSRVVTQFHYISWPDHGVPDSTAGILT
 |||||.||..|..|||.|.|.|.||.||..|||    |.     ...| ..|.|...|...|.|.|    . .|| ||..||..|||||||.|.. .| 
edFwrmvwelgvttivmLtelvelgrvkcaqYwp....ggsltygdftvtllkeehlddytvrtlevtnlgdgesrtvthyhylgwpdhgvpeslsllld

TIRRAKETRNqAAAGPMVVHCSAGVGRTGTLIAIDYNLDKAASENKVDVMGSLNEMRRQRTTMVQTEGQYIFIYRALA
 .....| ..    ||..||||||||||||.||... |. . .| .||.   ..|.|.||  .|||. ||.|.|.||.
flkavreale.dsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflyeall
0046845 (Phosphotyrosine protein) phosphatases II 1566-1853 3.1e-89 294.4 In-house 2-276 (284) alignment 
Range on Protein: 1566-1853
Range on HMM: 2-276/284.0
LDQEFRGLSQGPPSSNTRTDAAQQMANKSKNRFQNIMPYDASRVKLSALPGV-VGSDYINASYIDGF-----RQRKQFIATQGPMQSTLADFWRMVWEQE
|..||. | .  ..    ...|.  .|.||||...|.||| |||||. |.|   .||||||||.||.     ...|.|||||||...|..|||||||||.
leeefeellsltvklllslsvallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweqn

VHSIVMLTHLEESGRQKSEQYWPSLgSDPLNVGDLQVSISEEEHKSFGVERTLTLLNPV-SDQAREVKHWQFPNWPSSGEMGSGRDLVDLVMRVEDYARS
|. ||||| |.| ||.| .||||.  ...|. ||..| . .||.|.  . |||.| |   ... |.|.|.....||  |   | .||....  |... ..
vrvIVmltelvengrekcaqYwple.gevltygdftvtllseevkddytvrtleltnlgytgesrtvthfhytswpdhgvppspedlleflrlvrellen

kvvvpqeesiygnreainehaiLQQLKPTVVHCSAGVGRTGAYCAAVICLERMKQEN---KVDLYQVTKHLRTQRPGMVQTAEQYAFVYRVILDYLDK
                      | . .|.||||||||||||...|. ..||....|.   .||.... |.||.|||||||| ||| |||...|.|| .
......................lpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyealleylkl
0045450 (Phosphotyrosine protein) phosphatases II 1258-1533 9e-89 293.5 In-house 9-301 (307) alignment 
Range on Protein: 1258-1533
Range on HMM: 9-301/307.0
ISVSDLNTVIQQMAANSDFAFSEEYECIESGSEF---GRNYAIMDRNRQKNRFANILAYDHSRVPLHKLPND-PYSDYINANYI--------DGYNQPKS
|.. .|   .... ...   . .|.| . |   |    ...| .  |. |||. .||.|||.|| |. |... . ||||||.|.        |||.... 
idalkllllvllllldfltgllkefekllsvtvfllgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydlkrk

YIAAQGPLPHTLMDFWRMIWEQRVSVIVMVTNLEEKGRTKCHRYWPEEvgGQLPLTTNMSVFMTKQEEFPDMVIRHLTVQ---VSQQSRVVTQFHYISWP
.||.|||||.|. |||||.|||.|.||||.|.|.|.|| ||..|||.|  |.     |. | ... |. .....|.|.|.    ...|| ||.|||..||
fIatqgPlpetvedFwrmlweqgvtvivmltelvelgrekcaqywPde..geeltygnftvtllseehldgytvrtlevtdldgtgesrtvthfhytgwp

DHGVPDSTAGILTTIRRAKETRNQA-AAGPMVVHCSAGVGRTGTLIAIDYNLDKAASENK---VDVMGSLNEMRRQRTTMVQTEGQYIFIYRALA
|||||.|.. .|  |..... ...    ||..||||||||||||.||... |.   .|..   ||.   ....|.||  .||...||.|.|.||.
dhgvppsfeelldfieevrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyeall
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 1257-1557 1.5e-88 291.9 In-house 3-304 (305) alignment 
Range on Protein: 1257-1557
Range on HMM: 3-304/305.0
EISVSDLNTVIQQMAANSDFAFSEEYECIESGsEFGRNYAIMDRNRQKNRFANILAYDHSRVPLHKLPNDPYSDYINANYIDGYNQPKSYIAAQGPLPHT
 |...||.. |... ..|| .. ..|. . .  |   .    . |..|||...|  .|..|. | . .... ||||||.|.|||.. |.||.|||||..|
iialddlaayikearvysdkgleaqykslyee.eesidvgkkeankaknrlkeitlldddriiltekeslddsdyinasyvdgykrkkkyivaqgPlknt

LMDFWRMIWEQRVSVIVMVTNLEEKGRTKCHRYWPEEVGGQLPLtTNMSVFMTKQEEFPDMVIRHLTVQV---SQQSRVVTQFHYISWPDHGVPDSTAGI
. ||||.|.| .||.|||.|.| | |. ||..||||... .  .  ..|| .. .....| ..|.|.. .   ...||.|.|..  .|||||||.... .
vadfWrliveekvstivmltklveggkdkCrqYWpesktekkef.gefsvelksektasdyieRklkisiededkesrtvlqyqltdWPdhGvpqfatsl

LTTIRRAKETRNQAAAGPMVVHCSAGVGRTGTLIAIDYNLDKAASENKVDVMGSLNEMRRQRTTMVQTEGQYIFIYRALADGLSNIVTEMSPETLRKHFD
|. |.| ......    |..|||||||||||. ||.|  |...  |. |||.. |...|..|  ||||  || |.. ||.. .    |..  . || . .
lslikrvqkdqkkdkgvpllVhCsagvgRtGvfiavdialerlkkEevvdvfevlkqlRskrmkmvqtldqYvflhdaldelitcgdtsiigsnlrarvn

ELRK
 |.|
klkk
subfamily_PTPN12_pd Subfamily PTPN12 1289-1538 1.9e-87 287.8 In-house 28-279 (290) alignment 
Range on Protein: 1289-1538
Range on HMM: 28-279/290.0
SEFGRNYAIMDRNRQKNRFANILAYDHSRVPLHKLPNDPYSDYINANYIDGYNQPKSYIAAQGPLPHTLMDFWRMIWEQRVSVIVMVTNLEEKGRTKCHR
... .. .  ..|..|||. .|| ||.||| |.|  ... |||||||.| | .....|||||||||.|| ||||||||..|...||. .. | |..||.|
kvysteagekeenvkknrykDilPydksrvelskieeeegsdYinanfikgvegkleyiaaqgPLpktlddfWrmiweknveivvmaCrevelgkkkCer

YWPEEVGGQLpLTTNMSVFMTKQEEFP-DMVIRHLTVQVSQQSRVVTQFHYISWPDHGVPDSTAGILTTIRRAKETRNqAAAGPMVVHCSAGVGRTGTLI
|||||.. .|  . ...| ..... .  |..|| |.|.....||.|.|||| .||||||| |.  .|  |. ..|... . . |.|||||||||||||.|
YWpeegeeel.efgefevtleeekavdddflirtLkveaqkesrkvyqfhYtaWPDhgvPssaksllelielvrelqe.sedaPlvvhCsaGvGrtGtii

AIDYN---LDKAASENKVDVMGSLNEMRRQRTTMVQTEGQYIFIYRALADGLSN
||||    | .   ....||   . |.|.||...|||. || ..|.|.|. ...
aidyvrellkaekipeeldvfdlvlelrkqraalvqtkeqyelvykavaelvqk
0040438 (Phosphotyrosine protein) phosphatases II 1562-1855 2.6e-87 288.3 In-house 16-280 (317) alignment 
Range on Protein: 1562-1855
Range on HMM: 16-280/317.0
GGTQLDQEFRGLSQGPPSsntRTDAAQQMANKSKNRFQNIMPYDASRVKLSALPGVVGSDYINASYIDGFRQRKQFIATQGPMQSTLADFWRMVWEQEVH
. |.| .||. | . ...    .. |.  .||.|||. .|.|||.|||||| |.|. .||||||||.||......|||||||...|..||||||||| |.
dftalleefedllslkld...tysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyvdgpnlkrkfIatqgPlpntvedFwrmvweqgvt

SIVMLTHLEESGRQKSEQYWPSlgSDPLNVGDLQVSISEEEHKSFGVERTLTLLNPVSDQAREVKHWQFPNWPSSGEMGSGRDLVDLVMRVEDYArskvv
.|||||.||| ||.|..||||.   ..|..||..| . .||...  . |||.. .  ... |.|.|.....||  |   | ..|.|.. .|...      
vivmLteleelgrekcaqYwpl..getltygdftvtllseeelagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfleavreal.....

vpqeesiygnreainehAilQQLKPTVVHCSAGVGRTGAYCAAVICLERMKQENKVDLYQVTKHLRTQRPGMVQTAEQYAFVYRVILDYLDKQN
                 .  .. .|..|||||||||||...|| ..||....|..||.... |.|| ||||.||| ||| |.|...|.|| . .
.................e..dpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalleylkrkl
subfamily_PTPRK_pd Subfamily PTPRK 1258-1570 1.3e-86 285.3 In-house 4-312 (314) alignment 
Range on Protein: 1258-1570
Range on HMM: 4-312/314.0
ISVSDLNTVIQQMAANSDFAFSEEYECIESGsefgRNYAIMDRNRQKNRFANILAYDHSRVPLHKLPNDPYSDYINANYIDGYNQPKSYIAAQGPLPHTL
| | ||   |... ..  . | ||||..  |     . |  | ||.|||. .|||||.||| |. . .|| ||||||..||.|..|. .|..||||..|.
irvadllqsiallkraegygfkeeyeslfeg....wdaakkdenreknrsgdilaydrsrvflitidgdpssdyinaalidsykrpaafivtqgPlqetv

MDFWRMIWEQRVSVIVMVTNLEEKGRTKCHRYWPEEVGGqlplTTNMSVFMTKQEEFPDMVIRHLTVQV----SQQSRVVTQFHYISWPDHGVPDSTAGI
 ||||...... . |||.|.| |.|| || .||||.         .. | . . |   ..|.| ..|.      .. |.| ||....||||.|| |  |.
kdfWrlvydencasivmltelvevgrvkClkyWPedtev....ygdikvelvetellaelvvrifrveklargqeeirevrqfqflgWpdhdvPvsatgl

LTTIRRAKETRNQaAAGPMVVHCSAGVGRTGTLIAIDYNLDKAASENKVDVMGSLNEMRRQRTTMVQTEGQYIFIYRALADGLSNIVTEMSPETLRKH-F
|. .|| |.....  ||..||||||| ||||| ||||  || .  |. |||     ..| ... ||.|| ||.||| .. .      | .    ..   .
lklvrrvkksqee.eaGrivvhCsaGaGrtGtfiaidivldmieregvvdvfnavktlrsrkvnmveteeqykfiydvileaclcgetaipvsefkalyl

DELRKPVSSGGTQLDQEF
. .|    .  .|| .||
esirldpqtnssqlkeef
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 1257-1537 1.4e-86 285.4 In-house 4-291 (298) alignment 
Range on Protein: 1257-1537
Range on HMM: 4-291/298.0
EISVSDLNTVIQQMAANSD----FAFSEEYECIESGSE----FGRNYAIMDRNRQKNRFANILAYDHSRVPLHKLPNDPYSDYINANYIDGYNQPKSYIA
||...||.. .|..|| .       ...|.. ..|.|.    .  . |  ..|..|||.|.|.|.|.||| |.|  .|  |||||| ....|.. ...||
eieaedlkaalqklaavkkkkkltgyalefqrlnsvsseieeeekevarkpenkkkNRyadiialdssRvvLekedadeesdYiNAsflhaykgrnafia

AQGPLPHTLMDFWRMIWEQRVSVIVMVTNLEEKGRTKCHRYWPEEVGGQlplTTNMSVFMTKQEEFPDMVIRHLTVQ--VSQQSRVVTQFHYISWPDHGV
.|.||..|. |||||..|. ...|||.|||||...||.|.|||.|   .     ...| . ..||| |...|.|.|.   ....| | |.|..||||.||
tqaPltetvedFWrmvteedigtiVmltnleeldktkyhkywPdegket...ygeitvsllskeefadlivrklkvskkkeekerevrqlhftsWpdkgv

PDSTAGILTTIRRAKETRNQAAAGPMVVHCSAGVGRTGTLIAIDYNLDKAASENKVDVMGSLNEMRRQRTTMVQTEGQYIFIYRALADGLS
|  .  .|. .|. . ...||   |..|.|||||||.|| ||||  |...  |..|||.  .. .|..|...|||| ||.||| |  . |.
penatsvldllrkvrasqqqagnkpvivqCsaGvgRsGtfiaidsvlervkkeqvvDvfqvvkvlRkkrpgavqteeqYvfiyeavleald
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 1260-1534 1.6e-86 285.0 In-house 6-277 (288) alignment 
Range on Protein: 1260-1534
Range on HMM: 6-277/288.0
VSDLNTVIqQMAANSDFAFSEEYECI-ESGSEFGRNYAIMDRNRQKNRFANILAYDHSRVPLHKLPNDPYSDYINANYIDGYNQPKSYIAAQGPLPHTLM
.|... |. .. |..   |||||. . . ...   . .   .| .|||. |||.||. || |.||.. . .|||||.||||... | |||.||||..|. 
ispvakva.kksarnrtgfseeynsLaalektksvtagrlavnakknRyrnilpyDekrvklkkleeeagaDYinasyidgekkkkkyiatqgPladtvn

DFWRMIWEQRVSVIVMVTNLEEKGRTKCHRYWPEEvgGQLPLTTNMSVFMTKQEEFPDMVIRHLTVQVSQQSRVVTQFHYISWPDHGVPDSTAGILTTIR
|||....|...| |||.|.| |.|.|||..|||..  ..  .  .. | .....|  |.| |.| .. ... . .||..| .|||||||.|.| .|  .|
dfWelvyenktstivmltelveggktkCeeYWPda..dkpknyGsvtvtlveskeledfvlrklllekkkteleitqyqylaWpdhgvPeskapllellr

RAKETrNQAAAGPMVVHCSAGVGRTGTLIAIDYNLDKAASENKVDVMGSLNEMRRQRTTMVQTEGQYIFIYRALAD
  | . ||| .||..|||||||||||| ||.|  .|.  .|...||.| ....|.||...|||. ||.|||..|..
qvkva.nqadtgpiivhCsaGvGrtgtFialdalidaveeedyiDvagtvaklRkqRallvqtlkqYefiyevlls
0047943 (Phosphotyrosine protein) phosphatases II 1564-1851 1e-85 282.8 In-house 12-272 (273) alignment 
Range on Protein: 1564-1851
Range on HMM: 12-272/273.0
TQLDQEFRGLSQGPPssNTRTDAAQQMANKSKNRFQNIMPYDASRVKLsalpGVVGSDYINASYIDGFRQRKQFIATQGPMQSTLADFWRMVWEQEVHSI
|.| .||. | . .|  .  . .|.  .||.|||...|.||| |||||    |  |||||||||.||... ..|||||||...|..||||||||| |. |
tllleefelllslkp..lltysvallpenkdknrykdilpydhsrvkl....gdggsdyinAsyvdgynlkrkfiatqgPlpntvedfwrmvweqnvrvi

VMLTHLEESGRQKSEQYWPSLGSD-PLNVGDLQVSISEEEHKSFGVERTLTLLNPVSDQAREVKHWQFPNWPSSGEMGSGRDLVDLVMRVEDYARskvvv
|||| |.| ||.| .||||. | . .|..|...| . .||.|.  . |||.| |  ... |.|.|.....||  |   |  .|..... |... .     
VmLtelvelgrekcaqYwpleggelsltygkftvtllseetkddytvrtleltnlgtgesrtvthfhytgwpdhgvppslesllefielvrkale.....

pqeesiygnreainE---HailqqlKPTVVHCSAGVGRTGAYCAAVICLERMKQENKVDLYQVTKHLRTQRPGMVQTAEQYAFVYRVILDYL
              .   .      .|.||||||||||||...|. ..|.... |..||.... |.||.|||||||| ||| |.|...|.||
..............alpsn......gpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrflyealleyl
0043336 (Phosphotyrosine protein) phosphatases II 1555-1851 3.3e-85 281.2 In-house 11-277 (278) alignment 
Range on Protein: 1555-1851
Range on HMM: 11-277/278.0
LRKPVSSGGTQLDQEFRGLSQGPPssnTRTDAAQQMANKSKNRFQNIMPYDASRVKLSALPGVVGSDYINASYIDGFRQRKQFIATQGPMQSTLADFWRM
|.... .. | | .||  | . ..     .. |. ..||.|||. .|.||| |||||| |.|. .||||||||.||... ..|||||||...|..|||||
llelllnlktllllefeellsfkl...dtysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyvdgynvprkfiatqgPlpetvedFwrm

VWEQEVHSIVMLTHLEESGRQKSEQYWPslgSDPLNVGDLQVSISEEEHKSFGVERTLTLLNPVSDQAREVKHWQFPNWPSSGEMGSGRDLVDLVMRVED
|||. |..||||| |.| ||.|. ||||   ...|..||..|   .|||..  . |||.. |  ... |.| |.....||  |   |  .|.|.. .| .
vwelgvttivmLtelvelgrvkcaqYwp...ggsltygdftvtllkeehlddytvrtlevtnlgdgesrtvthyhylgwpdhgvpeslsllldflkavre

YArskvvvpqeesiygnreainehaiLQQLKPTVVHCSAGVGRTGAYCAAVICLERMKQENKVDLYQVTKHLRTQRPGMVQTAEQYAFVYRVILDYL
.                           . .|..|||||||||||...|. ..||... | .|||... |.||.||||.||| .|| |.|...|.||
al........................edsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflyealleyl
subfamily_Ptp69D_pd Subfamily Ptp69D 1257-1555 6.2e-85 280.0 In-house 3-305 (307) alignment 
Range on Protein: 1257-1555
Range on HMM: 3-305/307.0
EISVSDLNTVIQQMAANSDFAFSEEYECIES-GSEFGRNYAIMDRNRQKNRFANILAYDHSRVPLHKLPNDPYSDYINANYIDGYNQPKSYIAAQGPLPH
.|.. ||.. ...   ..|| . .||| .|.  ..   . .  . |  |||. .| |.|. || |.|.. . .||||||..| ||.. |..||||.|.  
aiaiddleealksrkrdtdfglakeyekLeareidkstkvsekkenalknRyedikafDktRvkLkkingkedsdYinasfikgykekkkfiaaqdPvea

TLMDFWRMIWEQRVSVIVMVTNLEEKGRTKCHRYWPEEvggQLPLTTNMSVFMTKQEEFPDMVIRHLTVQVSQ-------QSRVVTQFHYISWPDHGVPD
|. ||||||.|| | .|||..||.|| | ||..|||.|   .     .. | . ..|. .| .||.| |   .       .|| |.|.|| .|.|  ||.
tigDfWRmiaeqevtlivmlsnlteknrkkcakYWpie...devqygdilvklvseekhsdyiiReldvskkkeesgevedsrkvvqyhytgWkDskvPe

STAGILTTIRRAKETRNQAaAGPMVVHCSAGVGRTGTLIAIDYNLDKAASENKVDVMGSLNEMRRQRTTMVQTEGQYIFIYRALADGLSNIVTEMSPETL
.. |.|  |....|  ..   .|.||||||||||.|...|.|  |..   |.|||..    ..|.||. .||   ||.|.||||.|  |   |... ..|
vargllklieqvrelykln.rsPivvhCsaGvgrsgifvaldsllqqlkaedkvdifetvkdLrsqRnllvqsleqYvflyralldyssygdtdedvddl

RKHFDEL
 .....|
edaierl
DSPc_SM00195 1566-1851 1.5e-84 278.8 In-house 2-262 (263) alignment 
Range on Protein: 1566-1851
Range on HMM: 2-262/263.0
LDQEFRGLSQGPPSSntRTDAAQQMANKSKNRFQNIMPYDASRVKLSALPGVVGSDYINASYIDGFRQRKQFIATQGPMQSTLADFWRMVWEQEVHSIVM
|..||. | .  ...  .|. |.. .||||||..||.||| .||||.  ..  |||||||.||.| ...|..||||||..||..||||||||..|. |||
lkeefekleestspk..etteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivm

LTHLEESGRQKSEQYWPSLGSDPLNVGDLQVSISEEEHKS-FGVERTLTLLNPVSDQAREVKHWQFPNWPSSGEMGSGRDLVDLVMRVEDYARSKvvvpq
||  ||.|..| ..|||.   .. ..|...| . |.|.|.   . |||.| .   ...|.|...|. ||| .|   | .....|.  |.   ...     
lteeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkksksts.....

eesiygnreainehailqqLKPTVVHCSAGVGRTGAYCAAVICLERMKQENKVDLYQVTKHLRTQRPGMVQTAEQYAFVYRVILDYL
                    .|.||||||||||||..... |.|.....|.|||. .. |.||.|||||||| |||.|.|..||.|.
...................sgpivVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi
PTPc_SM00194 1566-1851 1.5e-84 278.8 In-house 2-262 (263) alignment 
Range on Protein: 1566-1851
Range on HMM: 2-262/263.0
LDQEFRGLSQGPPSSntRTDAAQQMANKSKNRFQNIMPYDASRVKLSALPGVVGSDYINASYIDGFRQRKQFIATQGPMQSTLADFWRMVWEQEVHSIVM
|..||. | .  ...  .|. |.. .||||||..||.||| .||||.  ..  |||||||.||.| ...|..||||||..||..||||||||..|. |||
lkeefekleestspk..etteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivm

LTHLEESGRQKSEQYWPSLGSDPLNVGDLQVSISEEEHKS-FGVERTLTLLNPVSDQAREVKHWQFPNWPSSGEMGSGRDLVDLVMRVEDYARSKvvvpq
||  ||.|..| ..|||.   .. ..|...| . |.|.|.   . |||.| .   ...|.|...|. ||| .|   | .....|.  |.   ...     
lteeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkksksts.....

eesiygnreainehailqqLKPTVVHCSAGVGRTGAYCAAVICLERMKQENKVDLYQVTKHLRTQRPGMVQTAEQYAFVYRVILDYL
                    .|.||||||||||||..... |.|.....|.|||. .. |.||.|||||||| |||.|.|..||.|.
...................sgpivVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi
Y_phosphatase Protein-tyrosine phosphatase 1301-1533 2.9e-84 277.5 Pfam-A 1-234 (235) alignment 
Range on Protein: 1301-1533
Range on HMM: 1-234/235.0
NRQKNRFANILAYDHSRVPLhklPNDPY-SDYINANYIDGYNQPKSYIAAQGPLPHTLMDFWRMIWEQRVSVIVMVTNLEEKGRTKCHRYWPEEVGGQLp
|..|||. .||.||..|| |    ...  ||||||||..||...|..||.||||..|. |||||.|...|.||||.|.||||||.||..||||| ...| 
nkkknRykdilpydktrvkl...kgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeesl.

LTTNMSVFMT-KQE-EFPDMVIRHLTVQVSQQS---RVVTQFHYISWPDHGVPDSTAGILTTIRRAKETRnQAAAGPMVVHCSAGVGRTGTLIAIDYNLD
 . ...| .. |.. .  ....|.|... ....   | |.|.|| .|||||||.|. ..| .||. .... .|  ||.|||||||||||||..|.|. |.
tygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkveksk.eaksgpvvVhCsaGvgRtgtfvaldille

KAASENKVDVMGSLNEMRRQRTTMVQTEGQYIFIYRALA
.. .|..|||.  ..|.|.||  |||.. ||||.|.|..
qleaeeevdvlqivkelRkqRpgmvqsleqYiflykail
Y_phosphatase Protein-tyrosine phosphatase 1301-1533 2.9e-84 277.5 In-house 1-234 (235) alignment 
Range on Protein: 1301-1533
Range on HMM: 1-234/235.0
NRQKNRFANILAYDHSRVPLhklPNDPY-SDYINANYIDGYNQPKSYIAAQGPLPHTLMDFWRMIWEQRVSVIVMVTNLEEKGRTKCHRYWPEEVGGQLp
|..|||. .||.||..|| |    ...  ||||||||..||...|..||.||||..|. |||||.|...|.||||.|.||||||.||..||||| ...| 
nkkknRykdilpydktrvkl...kgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeesl.

LTTNMSVFMT-KQE-EFPDMVIRHLTVQVSQQS---RVVTQFHYISWPDHGVPDSTAGILTTIRRAKETRnQAAAGPMVVHCSAGVGRTGTLIAIDYNLD
 . ...| .. |.. .  ....|.|... ....   | |.|.|| .|||||||.|. ..| .||. .... .|  ||.|||||||||||||..|.|. |.
tygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkveksk.eaksgpvvVhCsaGvgRtgtfvaldille

KAASENKVDVMGSLNEMRRQRTTMVQTEGQYIFIYRALA
.. .|..|||.  ..|.|.||  |||.. ||||.|.|..
qleaeeevdvlqivkelRkqRpgmvqsleqYiflykail
0036941 (Phosphotyrosine protein) phosphatases II 1568-1854 3.7e-84 277.8 In-house 17-280 (297) alignment 
Range on Protein: 1568-1854
Range on HMM: 17-280/297.0
QEFRGLSQGPPssNTRTDAAQQMANKSKNRFQNIMPYDASRVKLsalpGVVGSDYINASYIDGFRQRKQFIATQGPMQSTLADFWRMVWEQEVHSIVMLT
.||. | .  .  .  ...|.  .|..|||. .|.||| .||||    .  |||||||||.||... ..|||||||...|..||||||||| |..|||||
kefeellplll..lgslsvallpenleknRykdilpydhtRVkl....ddegsdYinAsyvdgydlkrkfIatqgPlpntvedFWrmvweqnvtvIvmlt

HLEESGRQKSEQYWPSLGSDPLNVGDLQVSISEEEH--KSFGVERTLTLLNPVSDQAREVKHWQFPNWPSSGEMGSGRDLVDLVMRVEDYARSKvvvpqe
 |.| ||.| .||||.   ..|..||..|   ..|.  ..  . |||....  ... |.|.|.....||  |   | ..|.|.. .|... .        
elvelgrekcaqywpleegesltygdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfielvrkvlkll......

esiygnreainehailQQLKPTVVHCSAGVGRTGAYCAAVICLERMK---QENKVDLYQVTKHLRTQRPGMVQTAEQYAFVYRVILDYLDKQ
                 . .|..|||||||||.|...|| ..|....    |..||.... |.||.||||.||| ||| |.|...|..| |.
................psggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallellkkk
0045450 (Phosphotyrosine protein) phosphatases II 1548-1851 3.8e-84 278.3 In-house 11-304 (307) alignment 
Range on Protein: 1548-1851
Range on HMM: 11-304/307.0
LRKHFDELRKPVSSGGTQLDQEFRGLSQGPPSSNTRTDAAQQMANKSKNRFQNIMPYDASRVKLSALPGV-VGSDYINASYI--------DGFRQRKQFI
..|   .... . .. | | .||. | .  .  .  ...|.  .||.|||...|.||| .||||| |.|   .||||||||.        ||... ..||
alkllllvllllldfltgllkefekllsvtvfllgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydlkrkfI

ATQGPMQSTLADFWRMVWEQEVHSIVMLTHLEESGRQKSEQYWPSLgSDPLNVGDLQVSISEEEHKSFGVERTLTLLNP-VSDQAREVKHWQFPNWPSSG
|||||...|..|||||.||| |. |||||.|.| ||.|  ||||.  ...|. |...|   .|||..  . |||.. .   ... |.|.|.....||  |
atqgPlpetvedFwrmlweqgvtvivmltelvelgrekcaqywPde.geeltygnftvtllseehldgytvrtlevtdldgtgesrtvthfhytgwpdhg

EMGSGRDLVDLVMRVEDYARSkvvvpqeesiygnreainehaiLQQLKPTVVHCSAGVGRTGAYCAAVICLERMKQENK---VDLYQVTKHLRTQRPGMV
   |  .|.|.. .|... ..                      |.. .|..|||||||||||...|| ..|.....|..   |||... |.|| ||||.|
vppsfeelldfieevrkalee......................lpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgav

QTAEQYAFVYRVILDYL
|. ||| |.|...|..|
qnpeqyrflyeallell
0039614 (Phosphotyrosine protein) phosphatases II 1554-1853 3.8e-84 277.9 In-house 22-291 (297) alignment 
Range on Protein: 1554-1853
Range on HMM: 22-291/297.0
ELRKPVSSGGTQLDQEFRGLSQGPPSsntrTDAAQQMANKSKNRFQNIMPYDASRVKLSALPGV-VGSDYINASYIDGFRQ-RKQFIATQGPMQSTLADF
 |..   .. |.|..||  | . .|.    .  |.  .||.|||...|.||| |||||. ..||  .||||||||.||...  ..|||||||...|..||
llllekansktllllefeellslkpd....ysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfIatqgPlpetvedF

WRMVWEQEVHSIVMLTHLEESGRqKSEQYWPSLGSdplNVGDLQVSISEEEHKSFGVERTLTLLNpvSDQAREVKHWQFPNWPSSGEMGSGRDLVDLVMR
||||||| |..||||| |.| || | .||||. |.   . ||..|   ..||..  . |||.. |  ... |.|.|.|...||  |   | ..| ...  
wrmvweqgvtvivmLtklvelgr.kcaqywpeegg...tygdftvtllkvehldgytvrtlevtn..ngesrtvthfqytgwpdhgvppslellleflel

VEDYARSkvvvpqeesiygnreAinehailQQLKPTVVHCSAGVGRTGAYCAAVICLERMKQENKVDLYQVTKHLRTQRPGMVQTAEQYAFVYRVILDYL
|... ..               .       .. .|..|||||||||||...|| ..||... | .||.... |.|| ||||.||| .|| |.|...|..|
vrealae...............l.......pkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydallell

DK
 .
kr
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 1258-1569 1.1e-82 272.4 In-house 6-312 (315) alignment 
Range on Protein: 1258-1569
Range on HMM: 6-312/315.0
ISVSDLNTVIQQMAANSDFAFSEEYECIESGSEFGRNYAIMDRNRQKNRFANILAYDHSRVPLHKLPNDPYSDYINANYIDGYNQPKSYIAAQGPLPHTL
| . .| | . |  |..   | ..|| |  |  .  . |    |.||||. ||.|||.||| |  | ||| |||.|||.|||||... |||||||.. ..
ipldqlityvaqkkastkngfkqdyesipggqlhpldvakkienkqknryiniiaydksrvqlpllendphsdyvnanfidGynkkrryiaaqgpnvasv

MDFWRMIWEQRVSVIVMVTNLEEKGRTKCHRYWPEEvggQLpLTTNMSVFMTKQEEFPDMVIRHLTVQVSQQSRVVTQFHYISWPDHGVPDSTAGILTTI
 ||||...|. .. |||.||| |. . |. .|||..   .. .  ...| . ..| . .. .| |.| . .. | | |.|| |||| ||| .|  ..  |
kdfwrlvfeedigkivmltnlvegekrkaekywpdk...kv.iyGkitvtrkseevnteytvrtlsvvfgdnirevvqlhytswpdmgvpkytiplmnli

RRAKETrNQAAAGPMVVHCSAGVGRTGTLIAIDYNLDKAASENKVDVMGSLNEMRRQRTTMVQTEGQYIFIYRALADGLSNIVTEMSPETLRKHFDELRK
|..|   .....|..|||||||||||||.|..|  ||.|  || .||   .. .|..|  |||.  || ||| || . .    | .. .   ...| |  
rtvkqh.htnsvgaivvhcsaGvGrtGtfitldavldqaeaenaidvynfitgvrqnrikmvqvaeqyqfiydalletfvcgdtsiaqdlylqrydslla

PVSSGGTQLDQE
|    |. | ||
pspdtgstllqe
0040439 (Phosphotyrosine protein) phosphatases II 1294-1534 1.8e-82 272.0 In-house 4-244 (249) alignment 
Range on Protein: 1294-1534
Range on HMM: 4-244/249.0
NYAIMDRNRQKNRFANILAYDHSRVPLHKLPNDPYSDYINANYIDGYNQPKSYIAAQGPLPHTLMDFWRMIWEQRVSVIVMVTNLEEKGRTKCHRYWPEe
..|..  |. |||. .||.|||||| |. ||. . ||||||.|||||.... .||.|||||.|. |||||.||....||||.|.|.|.|| ||..|||. 
svallpenkdknrypdilpydhsrvklsilpglflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywpl.

vgGQLPLTTNMSVFMTKQEEFPDMVIRHLTVQ--VSQQSRVVTQFHYISWPDHGVPDSTAGILTTIRRAKETRNQA-AAGPMVVHCSAGVGRTGTLIAID
  |.     ...| ... |...|...|.|...    ..|| |....|..|||||||.|.. .|  |..... ....   ||..||||||||||||.||..
..ggsleygdftvtllsvevkddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaay

YNLDKAASENKVDVMGSLNEMRRQRTTMVQTEGQYIFIYRALAD
. |.    |..||.   ....|.||  .||...||.|.|.||..
lmleqlekelgvdleeavkllrsqRpgavqnpeqyrflyealle
0042113 (Phosphotyrosine protein) phosphatases II 1295-1533 2.4e-81 268.0 In-house 3-240 (245) alignment 
Range on Protein: 1295-1533
Range on HMM: 3-240/245.0
YAIMDRNRQKNRFANILAYDHSRVPLHKLPNDPYSDYINANYIDGYNQPKSYIAAQGPLPHTLMDFWRMIWEQRVSVIVMVTNLEEKGRTKCHRYWPEev
.|.   |..|||. .||.|||.|| |   ..|. ||||||.|.|||.... .||.|||||.|. |||||.||.....|||.|..||.|| ||..|||.  
vallpenkdknrysdilpydhtrvklspdggdldsdyinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywpl..

gGQLPLTTNMSVFMTKQEEFPDMVIRHLTVQ--VSQQSRVVTQFHYISWPDHGVPDSTAGILTTIRRAKETRNQAAAGPMVVHCSAGVGRTGTLIAIDYN
 |.   . ...| ... | ..|...|.|.|.   . .|| |...||..||||||||... .|  ...... ... . ||..||||||||||||.||... 
.gesltygdftvtllseehlddytvrtlevtnlgddesrevihyhylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylm

LDKAASENKVDVMGSLNEMRRQRTTMVQTEGQYIFIYRALA
|. . .| .|..   . |.|.||  .|||..||.|.|.||.
leqlekelgvsleeavkelrsqRpgavqtpsqyrflyeall
subfamily_PTPN9_pd Subfamily PTPN9 1267-1532 2.7e-80 264.6 In-house 7-286 (297) alignment 
Range on Protein: 1267-1532
Range on HMM: 7-286/297.0
IQQMAANSDFAFSEEYECIESGSEFGRNYAIM-DRNRQKNRFANILAYDHSRVPLHKLPNDPYSDYINANYIDGYNQPKSYIAAQGPLPHTLMDFWRMIW
.. . ..     |.||. | . .  |. .| .   | .|||....| ||..|| | |...|..|||||||..|||.|.|..||.||||..|  |||||.|
vayvkekgkrGlskeyaeirnepveGtflasklranleknrytdvlcydetrvvlakvdedeasdyinanfvdGykqkkafiatqGplkktvsdfWrmvW

EQRVSVIVMVTNLEEKGRTKCHRYWPEEVGGQLPlTTNMSVFMTKQEEFPDMVIRHLTVQ--VSQQSRVVTQFHYISWPDHGVPDSTAGILTTIRRAKET
||.| ||||.| ..|.|| || .|||.| . .    ...||   ..||  | ..| |...    ..|| || | ..||||.|||.|.| .|  .. ..|.
eqevlvivmttrvvergrlkcgqyWpleeessae.fgdlsvsnveveeeedykvrvleiknvkteesrkvthfqflsWPdyGvPssaaslldvlekvrek

------------RNQAAAGPMVVHCSAGVGRTGTLIAIDYNLDKAASENKVDVMGSLNEMRRQRTTMVQTEGQYIFIYRAL
            . ..   |.|||||||.|||||.|..|..|..  ....|||. ... .| ||. ..||. || | | |.
qalavkelgdewkghpsgPPivvhcsaGiGrtGtfitldiclsrleevgtvdvvetvkllrtqrafsiqtpeqyefcylav
0045098 (Phosphotyrosine protein) phosphatases II 1294-1537 4.8e-80 264.2 In-house 26-273 (278) alignment 
Range on Protein: 1294-1537
Range on HMM: 26-273/278.0
NYAIMDRNRQKNRFANILAYDHSRVPlhklpndpysDYINANYIDGYnqPKSYIAAQGPLPHTLMDFWRMIWEQRVSVIVMVTNLEEKGRTKCHRYWPEe
..|..  |. |||. .||.||||||           |||||.|||||  || .||.|||||.|. |||||.||....||||.|.|.|.|| ||..|||| 
tpalylgnldknRykdilpydhsrVk..........dYINAsyidgy..pkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrekcaqywpe.

vgGQLPLTTNMSVFMTKQEEFPDMVIRHLTVQ------VSQQSRVVTQFHYISWPDHGVPDST--AGILTTIRRAKETRN------------QAAAGPMV
  |.     ...| ... |...|...|.|.|.       . .|| ||..||..|||||||...  . .|  ... .| ..            .   ||..
..ggsltygdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsggpvl

VHCSAGVGRTGTLIAIDYNLDKAasENKVDVMGSLNEMRRQRTT-MVQTEGQYIFIYRALADGLS
|||||||||||||.|... |.    |..||.   ..|.|.||   .||...||.|.|..|.. |.
VHCsaGvgRtGtlvaaylmlell..eggvdlleavkelrsqRpglavqnleqyrflyefllelll
0040439 (Phosphotyrosine protein) phosphatases II 1586-1851 6.1e-80 263.7 In-house 5-246 (249) alignment 
Range on Protein: 1586-1851
Range on HMM: 5-246/249.0
AAQQMANKSKNRFQNIMPYDASRVKLSALPGVVGSDYINASYIDGFRQRKQFIATQGPMQSTLADFWRMVWEQEVHSIVMLTHLEESGRQKSEQYWPSlg
 |. ..||.|||...|.||| |||||| |||. .|||||||||||... ..|||||||...|..|||||.||. ...|||||.|.| ||.| .||||.  
vallpenkdknrypdilpydhsrvklsilpglflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywpl..

SDPLNVGDLQVSISEEEHKSFGVERTLTLLNPVSDQAREVKHWQFPNWPSSGEMGSGRDLVDLVMRVEDYARSKvvvpqeesiygnreainehailQQLK
...|..||..|   ..|.|.  . |||.| |   .. |.|.|.|...||  |   |  ||.|.. .|... ..                        . .
ggsleygdftvtllsvevkddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleel......................pkgg

PTVVHCSAGVGRTGAYCAAVICLERMKQENKVDLYQVTKHLRTQRPGMVQTAEQYAFVYRVILDYL
|..|||||||||||...|| ..||... |..|||... |.||.||||.||. ||| |.|...|..|
pvlVHCsaGvgRtGtfiaaylmleqlekelgvdleeavkllrsqRpgavqnpeqyrflyeallell
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 1299-1535 1.5e-79 261.7 In-house 7-241 (250) alignment 
Range on Protein: 1299-1535
Range on HMM: 7-241/250.0
DRNRQKNRFANILAYDHSRVPLHKLPNDPYSDYINANYIDGYNQPKSYIAAQGPLPHTLMDFWRMIWEQRVSVIVMVTNLEEKGRTkCHRYWPEEVGGQL
 .|..|||.|.|.|.|.||| |.|   |  |||||| ...||.. |..||.||||..|. |||||..|. ...|||.|||.|...| .|.||| |.  . 
pqnkeknryadiialdssrvvLekekgdkesdyinasflhgyderkafiatqgPlqatiedfWrmvleeksgtivmLtnLkesekt.yhqywPvekaeky

pltTNMSVFMTKQEEFPDMVIRHLTVQVS--QQSRVVTQFHYISWPDHGVPDSTAGILTTIRRAKETRNQAAAGPMVVHCSAGVGRTGTLIAIDYNLDKA
    .. | . ..||| |...|.| .     ...|.| |.|...||| |||. .  .|  ... . ...|| ..|..|.|||||||.|. ||||  |...
...GdvtvsllskeefadytkrklklskakkaderivrqlhfvvWPdkgvPevatavLellkkvqasqqqagnaPvivqCsaGvgrsGafiaidavlerl

ASENKVDVMGSLNEMRRQRTTMVQTEGQYIFIYRALADG
  |..|||.  .. .|..|  .|... ||.|.|...   
kkekvvdvfkvikvlrkdrphavesleqyvfvyeiilka
subfamily_PTPN6_pd Subfamily PTPN6 1271-1533 2e-79 261.8 In-house 21-294 (306) alignment 
Range on Protein: 1271-1533
Range on HMM: 21-294/306.0
AANSDFAFSEEYECI---ESGSEFGRNYAIMDRNRQKNRFANILAYDHSRVPLHkLPNDPYSDYINANYIDG--YNQPKSYIAAQGPLPHTLMDFWRMIW
   .   |.||.| .   |. . . |. .   .|..|||. ||| .||.|| |.  |. | |||||||||..   .. |||||.|| |..|. |||||.|
eslekagfeeefeelqqeeakkllsrkegakpenkeknryknilPfDhtrvilk.epsvpgsdyinanyikkevkgsdksyiatqgclettvsdFWrmvw

EQRVSVIVMVTNLEEKGRTKCHRYWPEEVGGQLplTTNMSVFMTKQEEFPDMVIRHLTVQ---VSQQSRVVTQFHYISWPDHGVPDSTAGI---LTTIRR
..   ||||.|.  |.|. || ||||.|   .   . ..|| ......  | ..|.|.|.    ....| | |.|. |||||||| ..  .   |....|
qensrvivmttkevErgkekCarYWPdeeekee..yGkisvtnvseksladYilRelsvskkkkkkeerevfqyhfksWPdhgvpkdpgavLdfledvnr

AKETRNQAAAGPMVVHCSAGVGRTGTLIAIDYNLDKA---ASENKVDVMGSLNEMRRQRTTMVQTEGQYIFIYRALA
 .|. ..| |||.|||||||.|||||.| ||  |..      . ..|.  . . .|.||  .|||| || |.|.|..
kqeeleeaeagpivvhCsaGiGRtGtfiviDillkliekkgldadidiqklvksvreqrsglvqteqqykfvykaik
subfamily_PTPRG_pd Subfamily PTPRG 1559-1855 2.7e-79 261.9 In-house 14-291 (563) alignment 
Range on Protein: 1559-1855
Range on HMM: 14-291/563.0
VSSGGTQLDQEFRGLSQGPPSSNTRTDAAQQMANKSKNRFQNIMPYDASRVKLSALPGVVGS-DYINASYIDGFRQRKQFIATQGPMQSTLADFWRMVWE
 ..| . ...||  | .   |..  ....|.  || |||  ||..|| |||||| |||. .. |||||.||||... |.|||||||...|. |||||.||
hadgdigfseefealqsetiskdldaehsqkpenkrKnRylnivaydrsRvklsplpgkkkklDYinAnyidGyqkskafiatqgplkdtfddFWrmiWe

QEVHSIVMLTHLEESGRQKSEQYWPSlgSDPLNVGDLQVSISEEEHKSFGVERTLTLLN------PVSDQAREVKHWQFPNWPSSGEMGSgrDLVDLVMR
|.|. |||.| |.|.||.| ..|||.   .....| ||| . |||...   .|||.. |         |. ..|.......||  |   .   | .| . 
qnvaiivmitnlvergrrkcdvYWPk..desetygalqvtlieeevlalytvrtlviknlklkkkkqcdteklvrqyhytkWPdhgvPeh..slpvLifv

VEDyarskvvvpqeesiygnreainEHAILQQLKPTVVHCSAGVGRTGAYCAAVICLERMKQENKVDLYQVTKHLRTQRPGMVQTAEQYAFVYRVILDYL
. .                      . |  ..  |.|||||||||||| |..    |....|||.|..... ||.|.||. .||| ||| |.. ..|. .
kks......................saankaeaGPivvHcsaGvgrtGtyivldtllkqiqqenavnvfgflkhiraqRnflvqteEqYiflhdalleai

DKQN
  ..
aske
0042113 (Phosphotyrosine protein) phosphatases II 1587-1852 6.7e-78 256.7 In-house 4-244 (245) alignment 
Range on Protein: 1587-1852
Range on HMM: 4-244/245.0
AQQMANKSKNRFQNIMPYDASRVKLSALPGVVGSDYINASYIDGFRQRKQFIATQGPMQSTLADFWRMVWEQEVHSIVMLTHLEESGRQKSEQYWPSlgS
|. ..||.|||. .|.||| .|||||  .|  .||||||||.||.|. ..|||||||...|..|||||.||. ...||||| .|| ||.|..||||.  .
allpenkdknrysdilpydhtrvklspdggdldsdyinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywpl..g

DPLNVGDLQVSISEEEHKSFGVERTLTLLNPVSDQAREVKHWQFPNWPSSGEMGSGRDLVDLVMRVEDYARSkvvvpqeesiygnreainehailQQLKP
..|..||..|   .|||..  . |||.. |  .|. ||| |... .||  |.  . ..|.|.. .|... ..                        . .|
esltygdftvtllseehlddytvrtlevtnlgddesrevihyhylpwpdhgvpdllellldflefvrkalae.......................dsngp

TVVHCSAGVGRTGAYCAAVICLERMKQENKVDLYQVTKHLRTQRPGMVQTAEQYAFVYRVILDYLD
..|||||||||||...|| ..||... | .|.|... |.|| ||||.||| .|| |.|...|..|.
vlVHCsaGvgRtGtfiaaylmleqlekelgvsleeavkelrsqRpgavqtpsqyrflyeallellk
Y_phosphatase Protein-tyrosine phosphatase 1592-1848 6.2e-77 253.5 Pfam-A 1-234 (235) alignment 
Range on Protein: 1592-1848
Range on HMM: 1-234/235.0
NKSKNRFQNIMPYDASRVKLsalPGVVG-SDYINASYIDGFRQRKQFIATQGPMQSTLADFWRMVWEQEVHSIVMLTHLEESGRQKSEQYWPSLGSDPLN
||.|||...|.||| .||||    |  | ||||||.|..|... |.|||||||..||..|||||||...|..|||||.|||.||.| .||||.  ...|.
nkkknRykdilpydktrvkl...kgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeeslt

VGDLQVSIS-EEE-HKSFGVERTLTLLNPVSDQ-AREVKHWQFPNWPSSGEMGSGRDLVDLVMRVEDYArskvvvpqeesiygnreainehaiLQQLKPT
 ||..| .  .|. ...  . |.|.| .  ...  ||||.... ||| .|   | ..|.||. .|| .                          .. .|.
ygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkveksk........................eaksgpv

VVHCSAGVGRTGAYCAAVICLERMKQENKVDLYQVTKHLRTQRPGMVQTAEQYAFVYRVIL
|||||||||||| ..|. |.||....|..||..|. |.||.|||||||..|||.|.|..||
vVhCsaGvgRtgtfvaldilleqleaeeevdvlqivkelRkqRpgmvqsleqYiflykail
Y_phosphatase Protein-tyrosine phosphatase 1592-1848 6.2e-77 253.5 In-house 1-234 (235) alignment 
Range on Protein: 1592-1848
Range on HMM: 1-234/235.0
NKSKNRFQNIMPYDASRVKLsalPGVVG-SDYINASYIDGFRQRKQFIATQGPMQSTLADFWRMVWEQEVHSIVMLTHLEESGRQKSEQYWPSLGSDPLN
||.|||...|.||| .||||    |  | ||||||.|..|... |.|||||||..||..|||||||...|..|||||.|||.||.| .||||.  ...|.
nkkknRykdilpydktrvkl...kgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeeslt

VGDLQVSIS-EEE-HKSFGVERTLTLLNPVSDQ-AREVKHWQFPNWPSSGEMGSGRDLVDLVMRVEDYArskvvvpqeesiygnreainehaiLQQLKPT
 ||..| .  .|. ...  . |.|.| .  ...  ||||.... ||| .|   | ..|.||. .|| .                          .. .|.
ygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkveksk........................eaksgpv

VVHCSAGVGRTGAYCAAVICLERMKQENKVDLYQVTKHLRTQRPGMVQTAEQYAFVYRVIL
|||||||||||| ..|. |.||....|..||..|. |.||.|||||||..|||.|.|..||
vVhCsaGvgRtgtfvaldilleqleaeeevdvlqivkelRkqRpgmvqsleqYiflykail
subfamily_PTPRB_pd Subfamily PTPRB 1563-1854 1.5e-76 252.3 In-house 24-288 (293) alignment 
Range on Protein: 1563-1854
Range on HMM: 24-288/293.0
GTQLDQEFRGLSQGppSSNTRTDAAQQMANKSKNRFQNIMPYDASRVKLSALPGVVGSDYINASYIDGFRQRKQFIATQGPMQSTLADFWRMVWEQEVHS
 ... .|.  |..    ... ..||....|..|||..||.|||.|||||.|| .  |||||||.||.|......|||||||. .|. ||||||||.... 
dlrfseeyeelkav..gkdqavkaaelavnraknrytnilpydhsrvkLaalkdesgsDYinanyipgynsprefiatqGPlpetvddfWrmvwekkssi

IVMLTHLEESGRQKSEQYWPSlGSDPLNVGDLQVSISEEEHKSFGVERTLTLLNpvSDQAREVKHWQFPNWPSSGEMGSGRDLVDLVMRVEDYARSKvvv
|||||.| | |..| |.|||.  ..| . ||..|.. .||...  | |.|.. .  ... |.|....|  ||  |   . . |.|.| .|.......   
ivmltqlvekgkvkCeeYWPa.deepvlyGdikvtlvaeeeledwvirelkiek..ekeerkvrqyhftsWpdhgvPektktlldfvrtvreaiekt...

pqeesiygnreainehailQQLKPTVVHCSAGVGRTGAYCAAVICLERMKQENKVDLYQVTKHLRTQRPGMVQTAEQYAFVYRVILDYLDKQ
                   .. .|.||||||||||||.. |    |.....|. ||.. .  .||..|  .||| .|| |.....||.| |.
...................askrPivvhCsaGvGRtGtfialdrllqaieeedyvdifgivaelReeRnllvqtekqYifihqcvldllrkk
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 1299-1533 3.5e-76 250.7 In-house 18-261 (270) alignment 
Range on Protein: 1299-1533
Range on HMM: 18-261/270.0
DRNRQKNRFANILAYDHSRVPLHKLPNDPYSDYINANYIDGYN-QPKSYIAAQGPLPHTLMDFWRMIWEQRVSVIVMVTNLEEKGRTKCHRYWPEEVGGQ
 |... ||.|.||   ..|| |..| .|. . ||||||. |.. ..|.||||.|||| || .|||||||..|. |||.|.||||||.|| ||||.|.. .
argkklnRyadiLPsPatRvrleeleedsataYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkgrkkCerYWpaepkek

LPLT-TNMSVFMTKQEEFPDMVIRHLTVQVSQQSRVVTQFHYISWPDHGVPDSTA------GILTTIRRAKETRNQAAA-GPMVVHCSAGVGRTGTLIAI
. |.  ...|. ...|     ....|... . ..| .. |.| .||||||| ..        .|...|  ...... .  .|..|||||||||||||||.
vkledgkikvlalseekeegyiltrlrleekgeerrlvHfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkaePllvHcsaGvgRtGtlial

DYNLDKAASENKVDVMGSLNEMRRQRTTMVQTEGQYIFIYRALA
|. .    ...||||.  ..|.|..|. .||.  || |.|.|..
DiavrlLeetkkvdvlaiieelRkdRmalvqhpeqyeflykavv
0037934 (Phosphotyrosine protein) phosphatases II 1294-1532 5e-76 250.7 In-house 3-238 (243) alignment 
Range on Protein: 1294-1532
Range on HMM: 3-238/243.0
NYAIMDRNRQKNRFANILAYDHSRVPLhklpNDpySDYINANYIDGYnqPKsYIAAQGPLPHTLMD----FWRMIWEQRVSVIVMVTNLEEKGRTKCHRY
..|..  |. |||. .||.|||||| |    ..  |||||||.|...  |. .|| |||||.|. |    ||||.||....||||.|.|.|.|| ||..|
siallpenlsknrysdilpydhsrvkl....eg..sdyinanliyvt..pr.liatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqy

WPeevgGQLpLTTNMSVFMTKQEEFPDMVIRHLTVQV---SQQSRVVTQFHYISWPDHGVPDSTAGILTTIRRAKETRNQ-------AAAGPMVVHCSAG
||    |.     ...| ....|...|...|.|...    ....| |...||..|||||||||.. .|  .. ..|  ..          ||..||||||
wp....gev.tygdftvtllseehlddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaG

VGRTGTLIAIDYNLDKAasenKVDVMGSLNEMRRQRTT-MVQTEGQYIFIYRAL
|||||||||... |..     .||.   ....|.||   .|||..||.|.|.||
vgRtGtliaaylmllll....gvdleeavkllreqRpgkavqtpsqyrflyeal
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 1277-1585 5.4e-76 250.7 In-house 19-329 (515) alignment 
Range on Protein: 1277-1585
Range on HMM: 19-329/515.0
AFSEEYECIESGSEFGRNYAIMDRNRQKNRFANILAYDHSRVPLHKLPNDPYSDYINANYIDGYNQPKSYIAAQGPLPHTLMDFWRMIWEQRVSVIVMVT
 ||||.  .     . .  |  . | .|||. ||| || .|| |  . ..| |||.|| || ...  |.|||.|||.. .. ||||......|. |.|||
lfseefhdlpgpniypqtvaqeeinfkknryknilPydsvrvklevindnPhsdyfnasyipsfdndkayiasqgPnkasvddfWrlvlqenvttiamvt

NLEEKGRTKCHRYWPEEVGGQLPLtTNMSVFMTKQEEFPDMVIRHLTVQVSQQSRVVTQFHYISWPDHGVPDSTAGILTTIRRAKETRNQAAaGPMVVHC
.|.|  . || .|||.  |  . .  ...| .   |   ....|.|||  ...|| |||||.  |||.|||  |  .|  |.  |  ..| .  |...||
klkegdkikcgkyWPdkpgdsvkf.GsikvelvsleactggikrkltvlkgddsrtvtqfhfteWPdkGvpkhtssllklikevkadhgqyt.hpliihc

SAGVGRTGTLIAIDYNLDKAASENKVDVMGSLNEMRRQRTTMVQTEGQYIFIYRALADGLSNIVTEMSPETLRKHFDELRKPVS-SGGTQLDQEFRGL--
|||||||| .|.||  . .|.  . |||.  .. .|..|  .|||. || ||| |. . |    | .    .  |...|       | ... .||. |  
saGvGrtGvvisidsvvahakttrmvdvfnfvtnirqkrpylvqtqeqyafiygavledllwrntlipvihftdhlqdlhssgdgrgrskmtkefqtlks

-SQGPPSSNTRTD
    ||.|.||. 
lcpdppasqtrsg
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 1256-1535 6.4e-76 250.7 In-house 9-294 (319) alignment 
Range on Protein: 1256-1535
Range on HMM: 9-294/319.0
HEISVSDLNTVIQQMAANSDFA-----FSEEYE--CIESGSEFGRNYAIMDRNRQKNRFANILAYDHSRVPLHKLPNDPYSDYINANYIDGYNQPKSYIA
....| |...  ||.. .|||      .  |.   |  . .   ...| .|.|. |||. ||||.|...| |..|    .|||||| ...|| ... |||
sdvavpdfpayyqqlsnksdfdddltklevefrracklgvnladqtfanldqnkdknriinilafdknvvklerliGeefsdyinasfvtGyqrkdkyia

AQGPLPHTLMDFWRMIWEQRVSVIVMVTnleekgRTKCHRYWPEEVGGQlplTTNMSVFMTKQEEFPDMVIRHLTVQV---SQQSRVVTQFHYISWPDHG
|||||. || ||||||||...| ||..|      . || .||| ..  .     .. | ..  ||  . |.|.. .      .. | .||||.  |||.|
aqGPldntladfWrmiweyncstivllt......kdkcsqywplkivik...eerfkvkvdsveetaeyvvrdielsedgkekdirkitqfhflGwpdvG

VPDSTAGILTTIRR-AKETRNQAAAGPMVVHCSAGVGRTGTLIAIDYNLDKAASENKVDVMGSLNEMRRQRTTMVQTEGQYIFIYRALAD----G
|||... ... ...  . |. .    ..||||||||||||. |..|  ||.   |..|||   ....|.|| |.||   || ||| || .    |
vpdypsdlmrlvkkvrhltskenhranivvhcsaGvGrtGvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalleehlfg
subfamily_PTPN9_pd Subfamily PTPN9 1568-1853 2.4e-75 248.3 In-house 20-292 (297) alignment 
Range on Protein: 1568-1853
Range on HMM: 20-292/297.0
QEFRGLSQGPPSSntRTDAAQQMANKSKNRFQNIMPYDASRVKLSALPGVVGSDYINASYIDGFRQRKQFIATQGPMQSTLADFWRMVWEQEVHSIVMLT
.|.  . . |..   . .|... || .|||..... || .||.|. ...   ||||||...||..|.| |||||||.. |  |||||||||||  ||| |
keyaeirnepveG..tflasklranleknrytdvlcydetrvvlakvdedeasdyinanfvdGykqkkafiatqGplkktvsdfWrmvWeqevlvivmtt

HLEESGRQKSEQYWPSLGSDPLNVGDLQVSISEEEHKSFGVERTLTLLNPVSDQAREVKHWQFPNWPSSGEMGSGRDLVDLVMRVEDYARSKVvvpqeeS
...| || |  ||||.   .  . |||.||  | |...  ..|.|.. |   .. |.| |.||  ||  |   |. .|.|..  | ..  . |      .
rvvergrlkcgqyWpleeessaefgdlsvsnveveeeedykvrvleiknvkteesrkvthfqflsWPdyGvPssaaslldvlekvrekqalav......k

IYGNREAINehailQQLKPTVVHCSAGVGRTGAYCAAVICLERMKQENKVDLYQVTKHLRTQRPGMVQTAEQYAFVYRVILDYLDK
  |.... .      .  | |||||||.||||....  |||.|......||. .. |.|||||  ..|| |||.| |  .|.|  .
elgdewkgh.....psgPPivvhcsaGiGrtGtfitldiclsrleevgtvdvvetvkllrtqrafsiqtpeqyefcylavleyale
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 1277-1564 2.6e-75 248.2 In-house 20-306 (315) alignment 
Range on Protein: 1277-1564
Range on HMM: 20-306/315.0
AFSEEYECIESGSEFGRNYAIMDRNRQKNRFANILAYDHSRVPLHKLPNDPYSDYINANYIDGYNQPKSYIAAQGPLPHTLMDFWRMIWEQRVSVIVMVT
 ||||.  .     . .. |  . | .|||. ||| .|..|| |  . ..| |||||| || .... |.|||.||||. .. |||||.....|. |||||
lfseefhdlpdPdiyrqrvaretinfkknryknilPldsarvkleviddsPdsdyinasyiksvdddkayiasqgPlkasvddfwrmvlqekvttivmvt

NLEEKGRTKCHRYWPEEVGgQLPLTTNMSVFMTKQEEFPDMVIRHLTVQVSQQSRVVTQFHYISWPDHGVPDSTAGILTTIRRAKETrNQAAAGPMVVHC
...|  . || .|||.. . ..    ...| . . |   |.|.|.|... |..|| ||||..  |||.||.  |. .|  |.  |   |.    ...|||
kkqegdkikcrqywPdrka.dsvefGsikvellsleadtdgvarklvtrkseesrtvtqfqftewPdkGvdkqtssllklikevkad.ngkkefsllvhc

SAGVGRTGTLIAIDYNLDKAASENKVDVMGSLNEMRRQRTTMVQTEGQYIFIYRALADGLSNIVTEMSPETLRKHFDELRKPVSS-GGT
|||||||| .|.||  ..... .. |||.  ....|..|  .|||| .| ||| |. . |    | .    .  |...|.  |.  | .
saGvGrtGvvisidevvaqikrtrsvdvfnfvknlrakrpylvqteeeyafiydavledllwrntlilvihftdhlqdlhtsvdgsgrs
0045098 (Phosphotyrosine protein) phosphatases II 1577-1851 3.4e-75 248.3 In-house 18-272 (278) alignment 
Range on Protein: 1577-1851
Range on HMM: 18-272/278.0
PPSSNTRTDAAQQMANKSKNRFQNIMPYDASRVKlsalpgvvgsDYINASYIDGFrqRKQFIATQGPMQSTLADFWRMVWEQEVHSIVMLTHLEESGRQK
..... .   |.   |..|||. .|.||| ||||          ||||||||||.  .|.|||||||..||.||||||.||. ...|||||.|.| ||.|
llgipseitpalylgnldknRykdilpydhsrVk..........dYINAsyidgy..pkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrek

SEQYWPSlgSDPLNVGDLQVSISEEEHKSFGVERTLTLLNP----VSDQAREVKHWQFPNWPSSGEMGSG--RDLVDLVMRVEDYAR---SKVVVPQees
 .||||.  ...|. ||..| . .||. .  . |||.. |      ... |.|.|.....||  |   .   . . .|. ..... .   |....     
caqywpe..ggsltygdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllssl...

iygnreainehAILQQLKPTVVHCSAGVGRTGAYCAAVICLERMkqENKVDLYQVTKHLRTQRPG-MVQTAEQYAFVYRVILDYL
            .|.. .|..|||||||||||...|| ..||..  |..|||... |.||.|||| .||. ||| |.|...|..|
...........llldsggpvlVHCsaGvgRtGtlvaaylmlell..eggvdlleavkelrsqRpglavqnleqyrflyefllell
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 1296-1534 1.3e-74 245.8 In-house 23-266 (274) alignment 
Range on Protein: 1296-1534
Range on HMM: 23-266/274.0
AIMDRNRQKNRFANILAYDHSRVPL-HKLPNDPYSDYINANYIDGYN-QPKSYIAAQGPLPHTLMDFWRMIWEQRVSVIVMVTNLEEKGRTKCHRYWPEE
  . .. .|||. .||  ..||| | .. ..|. |.||||||| ||. . | |.|.|||||.|..||||||....|.||||.|.|.|. ..||..|.|..
ldvfgsqtknryktilPnensrvllesessededssyinanyikGydeeskayvatqGPlpntvadfWrmiyqeevqvivmltklkeaneqkCavyfPda

VGGQLPL-TTNMSVFMTKQEEFPDMVIRHLTVQVSQQSRVVTQFHYISWPDHGVPDSTAGILTTIRRAKETRNQAA--AGPMVVHCSAGVGRTGTLIAID
 . ..    ..... ..|  |  |  .|.|... ....| |. . | .|||| .||..  .| ...  .|.|....  ..|.|||||||.||||  |||.
edyeiserygdveikvekiverndysvrklvlkylerersvkhywytdWPdhksPddantlldlvleveesreeenaklapvvvhCsaGiGrtGcfiais

YNLDKAASENKVDVMGSLNEMRRQRTTMVQTEGQYIFIYRALAD
  . .   |..|||..   ..| .|  ||||. || .|.|||. 
iavrqlreeivvdvlkivcnlrldrGGmvqtseqyelihralcl
subfamily_PTPN13_pd Subfamily PTPN13 1298-1537 2.1e-74 245.2 In-house 34-270 (273) alignment 
Range on Protein: 1298-1537
Range on HMM: 34-270/273.0
MDRNRQKNRFANILAYDHSRVPLHKLPNdpysdYINANYIDGY--NQPKSYIAAQGPLPHTLMDFWRMIWEQRVSVIVMVTNLEEKGRTKCHRYWPEEVG
 ..|..|||. |.| ||..||.| .  .     ||||..|     ..  .|||.|||||.|  |||.|.|||...||.|||.  |||. ||||||||. .
kkenkdknryrnvlPydetrvklgdegg.....yinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweqkaeviamvtlekekgkvkchrywPeskn

GQLPLTTNMSVFMTKQEEFPDMVIRHLTVQVS--QQSRVVTQFHYISWPDHGVPDSTAGILTTIRRAKETRNqaAAGPMVVHCSAGVGRTGTLIAIDYNL
 .| ..  . | . |...  ..|.|.|.|. |  ..|| |.......||||||| |.| .|. ... .. ..   |||.|||||||.||.||||.||  |
kklkvsnrlevellkvqkldgfvvralavkdsesgesrevahlnfvkwPdhgvPssaaellqfvaevrrlqt..dagPivvhcsaGiGrsGtlitidvvl

DKAASENKVDVMGSLNEMRRQRTTMVQTEGQYIFIYRALADGLS
.  . ....||   ....|.|| ..|||. ||||.|.|. . |.
glierdkefdvkeivrklreqrqgvvqtkdqyifvykailevlk
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 1293-1534 2.5e-74 245.3 In-house 17-253 (284) alignment 
Range on Protein: 1293-1534
Range on HMM: 17-253/284.0
RNYAIMDRNRQKNRFANILAYDHSRVPLHKLPNDPYSDYINANYIDGYNQPKSYIAAQGPLPHTLMDFWRMIWEQRVSVIVMVTnleekgRTKCHRYWPE
...| .|.|. |||. .|||.|...| |..|    .|||||| .| || ... |||.||||. || ||||||||...| ||..|      . || .||| 
qtfanldqnkdknrighilafdknvvklerliGeefsdyinasfitGyqrkdkyiatqGPldntladfWrmiweyncstivllt......kdkcsqywpl

EVGGQlplTTNMSVFMTKQEEFPDMVIRHLTVQV---SQQSRVVTQFHYISWPDHGVPDSTAGILTTIRR-AKETRNQAAAGPMVVHCSAGVGRTGTLIA
..  .     .. | ..  ||  ..|.|.. .      .. | ..|||.  |||.||||... ... ...  . |. .    ..||||||||||||. |.
kivik...eerfkvkvdsveeseeyvvrdielsedgkekdirkirqfhflgwpdvgvpdypsdlmrlvkkvrhltskenhranivvhcsagvgrtgvyiv

IDYNLDKAASENKVDVMGSLNEMRRQRTTMVQTEGQYIFIYRALAD
.|  ||.   |..|||.  ....|.||.|.||   || ||| || .
ldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalle
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 1561-1853 1.1e-72 239.5 In-house 18-281 (288) alignment 
Range on Protein: 1561-1853
Range on HMM: 18-281/288.0
SGGTQLDQEFRGLsqGPPSSNTRTDAAQQMANKSKNRFQNIMPYDASRVKLSALPGVVGSDYINASYIDGFRQRKQFIATQGPMQSTLADFWRMVWEQEV
.. |.. .|.. |   .  ..  ..|...  |..|||..||.|||  ||||  |. . |.|||||||||| ...|..||||||...|. |||..|.|...
rnrtgfseeynsL..aalektksvtagrlavnakknRyrnilpyDekrvklkkleeeagaDYinasyidgekkkkkyiatqgPladtvndfWelvyenkt

HSIVMLTHLEESGRQKSEQYWPSlGSDPLNVGDLQVSISEEEHKSFGVERTLTLLnpVSDQAREVKHWQFPNWPSSGEMGSGRDLVDLVMRVEDYARSKv
. |||||.| | |..| |.|||. . .| | |...| . |....   |.|.| |    . . .|....|.  ||  |   | ..|..|.  |.    .. 
stivmltelveggktkCeeYWPd.adkpknyGsvtvtlveskeledfvlrkllle..kkkteleitqyqylaWpdhgvPeskapllellrqvkvanqad.

vvpqeesiygnreainehailqqLKPTVVHCSAGVGRTGAYCAAVICLERMKQENKVDLYQVTKHLRTQRPGMVQTAEQYAFVYRVILDYLDK
                       ..| .||||||||||| . |.   ......|...|.  . ..|| ||. .||| .|| |.|.|.|.  ..
.......................tgpiivhCsaGvGrtgtFialdalidaveeedyiDvagtvaklRkqRallvqtlkqYefiyevllsliee
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 1258-1536 4.2e-72 237.5 In-house 2-278 (287) alignment 
Range on Protein: 1258-1536
Range on HMM: 2-278/287.0
ISVSDLNTVIQQMAANSDFAFSEEYECIES--GSEFGRNYAIMDRNRQKNRFANILAYDHSRVPLHklpnDPYSDYINANYIDGYNQPKSYIAAQGPLPH
|.|. .. ....  |...  |.. .  .|.   .|     .|  .|..|||...|| .|  ||.|.    .   ||||| .||||.. | .|.|..|. .
ipvekfgefvakghakgnegfknqftvleqvtqredevthniasqnkdknRltqilvpdnyrvllk....gehpdyinavfidgykekkafiiaesPmfn

TLMDFWRMIWEQRVSVIVMVTNLEEKGRTKCHRYWPEEVGgqlPLTTNMSVFMTKQEEFPDMVIRHLTVQVSQ---QSRVVTQFHYISWPDHGVPDSTAG
|. .||..|....|..|||.....|. . .|..|||||      .  . .. ....|   ....|.| |. ..   . . |.|... .|...|   . . 
tarnfWkliddrnvtaivmlcqekendeevcyqyWpeeks...vvlGeyniellneevnagyierklevknknkagdkqqvkqyqitnWdstgkvtepqt

ILTTIRRAKETRNQAAAGPMVVHCSAGVGRTGTLIAIDYNLDKAASENKVDVMGSLNEMRRQRTTMVQTEGQYIFIYRALADGL
||  | .   |. . . ...|||||..|||.....|..  ..|.  |  .||.  |...| |. ..|||  ||.||. ..   |
illvieemyktqrkrgntsivvhCsdtvGrsamfcaaattinkckteGviDvfqvlksqriqkpgsvqtveqykfindivleyl
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 1258-1542 6.2e-72 237.4 In-house 5-294 (325) alignment 
Range on Protein: 1258-1542
Range on HMM: 5-294/325.0
ISVSDLNTVIQQMAANSDFAFSEEYECIESGSEFGRNYAIMDRNRQKNRFANILAYDHSRVPLHKLPNDPYSDYINANYIDGYNQPKSYIAAQGPLPHTL
|.| .|   ...  |. . .|. |.. . |     .. |    |..|||| |..|.|.||| |  . .|| ||||||.|.  . . . ..||| ||..|.
iavvnlvehvekkkaqdqdgfahefgllpsddgiakkvamkpenkaknrfknvvaldksrvvletkkddpssdyinasylrddkkkdvflaaqaPltati

MDFWRMIWEQRVSVIVMvTNLEEKGRTKCHRYWPEEVGGQLPLtTNMSVFMTKQEEFPDMVIRHLTVQVSQQ--SRVVTQFHYISWPDHGVPDS---TAG
 |.||.. . | ||.|. .|  ..|  .|  |||.|.|    .   . | .   ||. | | | | |.  ..  .| | ||.. ||.| ||.      . 
ndlWrlvldWrcsvvvv.lneldlgkdrcavywpkemgksktf.GglevklrtieeisdyvhrvldvkqvkkGetrsvkqfqlqswddmGvqkrpatlis

ILTTIRRAKET--RNQAAAGPMVVHCSAGVGRTGTLIAIDYNLDKAASENKVDVMGSLNEMRRQRTTMVQTEGQYIFIYRALADGLSNIVTE
|| ..   .|.   |  |..|..|||||||||||..|..   |.|   | .||..|... .|..| .||.|  |||.|| ||.. . .  |.
ilqlvkavservtantkastpilvhcsaGvGrtGvfislysalakvieesrvdifgfvkklrkdrpsmvetvdqyiliyealveaymsgntd
subfamily_Ptp69D_pd Subfamily Ptp69D 1566-1867 7.2e-72 237.1 In-house 24-302 (307) alignment 
Range on Protein: 1566-1867
Range on HMM: 24-302/307.0
LDQEFRGLSQGppSSNTRTDAAQQMANKSKNRFQNIMPYDASRVKLSALPGVVGSDYINASYIDGFRQRKQFIATQGPMQSTLADFWRMVWEQEVHSIVM
| .|.. | .    ..  | ....  |. |||...|...|  ||||. ..|   |||||||.| |....|.||| |.|...|. |||||..||||. |||
lakeyekLear..eidkstkvsekkenalknRyedikafDktRvkLkkingkedsdYinasfikgykekkkfiaaqdPveatigDfWRmiaeqevtlivm

LTHLEESGRQKSEQYWPSLgsDPLNVGDLQVSISEEEHKSFGVERTLTLLNPV-----SDQAREVKHWQFPNWPSSGEMGSGRDLVDLVMRVEDYARSKv
|. |.|  |.| ..|||    |  . ||. | . .||..|  ..|.| . .        .. |.|  ... .|. |    . | |..|. .|..  . . 
lsnlteknrkkcakYWpie..devqygdilvklvseekhsdyiiReldvskkkeesgevedsrkvvqyhytgWkDskvPevargllklieqvrelykln.

vvpqeesiygnreainehailqqLKPTVVHCSAGVGRTGAYCAAVICLERMKQENKVDLYQVTKHLRTQRPGMVQTAEQYAFVYRVILDYLDKQNGAGPM
                         | ||||||||||.| . |  . |...|.|.|||.....|.|| ||. .||  ||| |.|| .||| .. .    .
.......................rsPivvhCsaGvgrsgifvaldsllqqlkaedkvdifetvkdLrsqRnllvqsleqYvflyralldyssygdtdedv

AAMESMY
  .|. .
ddledai
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 1258-1537 9.8e-72 236.2 In-house 2-284 (290) alignment 
Range on Protein: 1258-1537
Range on HMM: 2-284/290.0
ISVSDLNTVIQQMAANSDFAFSEEYECIESG-SEFGRNYAIMDRNRQKNRFANILAYDHSRVPLHKLPNDP--YSDYINANYIDGYNQPKSYIAAQGPLP
| |...   ...  |. .  | .... ..|| ||.  ....   |...||||||. ||  |..|.......    .|||| ||.||.. |.|||.|||..
ipvdkfgefvanghakgnegfrnqfkmldsgesehtvtvgltssnkllnRfanivvyddnritLrpisghkDCtneyinAcyikgykekkqyiatqgpvs

HTLMDFWRMIWEQRVSVIVMVTNLEEKGRTKCHRYWPEEvGGQLplTTNMSVFMTKQEEFPDMVIRHLTVQVSQQ---SRVVTQFHYISWPDHGVPDSTA
.||.|||..||...|..|||.||  |.|..||. |||.. . .     ..|. ....|.. ....|.| |. ...   .. |||..  .|...|    ..
ntlvdFWkliwqekvtiivmltniieegkvkCqqYWpds.dtka..ygefsikllneetlneyierklevknknsagakqsvtqyqitnwdstgkvtnpq

GILTTIRRAKETRNQAAAGPMVVHCSAGVGRTGTLIAIDYNLDKAASENKVDVMGSLNEMRRQRTTMVQTEGQYIFIYRALADGLS
.||..|..  .|. .   ...|||||..|||.....|..  ..|. .|  .||.  |...| |.  .|||. || .|.. .   |.
tillvieemyktqrkrgntsivvHCSdtvgrsavfcaaattinkcktegvidvfqvlksqRiqkpgsvqtvqqyqgifqivltyld
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 1252-1538 2e-71 235.5 In-house 4-286 (297) alignment 
Range on Protein: 1252-1538
Range on HMM: 4-286/297.0
PVERHEISVSDLNTVIQQmAANSDFaFSEEYECIESGSEFGRNYAIMDRNRQKNRFANILAYDHSRVPLHKLPNDPYSDYINANYIDGYNQpkSYIAAQG
| ||. | .||..|..|.   ..|. ||||. |. .   .    |    | .|.|..||| || ||| |. . .|| |||.|| .. |...   .|. | 
pkerrpiplsdfatlvqk.nrhtdv.fseeflclpeaniqpqtvaekkvnfeksRYkniLPydssRvkLaivnddpdsDyvnasfvkgnkh..rlittqm

PLPHTLMDFWRMIWEQRVSVIVMVTNLEEKGRtKCHRYWPEEVGGQlplTTNMSVFMTKQEEFPDMVIRHLTVQVSQ--QSRVVTQFHYISWPDHGVPD-
| . |. |||.|.....||.|||.....|. . || |||...   .     ..|| ..  .|   .. |.|.|. ..  . ||| |.....|||. |.  
PmkatvadfWamvldeqvstivmlnddnerdk.kcaryWsdkgvtt...fGdvsvvllsvsereGfikrelevtkgkakarrvvkqyqfveWPdkaverk

-STAGILTTIRRAKETRNQAAAGPMVVHCSAGVGRTGTLIAIDYNLDKAASENKVDVMGSLNEMRRQRTTMVQTEGQYIFIYRALADGLSN
 |.. .|  |   ... .| | ||..|||.||||||| |..||  . .|  |..||..| .. .|..|  .|||. || |.| |. . |. 
dsassllklisevrkdfsqnaegPllvhclaGvGrtgvlltidsvvaeakrekevdifglvkklrqerpylvqtkeqykfvyvavlealls
subfamily_PTPN3_pd Subfamily PTPN3 1296-1532 1.3e-70 232.5 In-house 36-271 (280) alignment 
Range on Protein: 1296-1532
Range on HMM: 36-271/280.0
AIMDRNRQKNRFANILAYDHSRVPLHKLPNdpysDYINANYID----GYNQPKSYIAAQGPLPHTLMDFWRMIWEQRVSVIVMVTNLEEKGRTKCHRYWP
| . .| .|||. .||.||. || |.. ..    |||||||..    . .. . |||.||||..|  |||.|.|||..|.|||.|.| |.||.|||.|||
arkpenlsknryrdilpydatrvklkeset....dyinanyvnmeipstglvnryiatqGPlaktatdfWqmvweqksslivmlttlverGrvkChqyWP

EeVGGQLPLTtNMSVFMTKQEEFPDMVIRHLTVQVSQ--QSRVVTQFHYISWPDHGVPDSTAGILTTIRRAKETRNqAAAGPMVVHCSAGVGRTGTLIAI
|  . .| .. ..|| ..|..|   .|.|.|... ..  ..| ..|. |..||||||||..| .|. ..| ...|. ..  |.|||||||.|||| ||..
e.tedeleyg.efsvkcekedetksyvlrelvlkdketkeerkilqlqylaWpdhgvPddsadflefvervrklrs.gkeePvvvhCsaGigrtGvlill

DYNLDKAASENKVDVMGSLNEMRRQRTTMVQTEGQYIFIYRAL
.  | .  ....| ..  . .|| ||...|||..|| |.  |.
etalalieaaepvypldivrtmrdqramlvqtasqykfvCeai
subfamily_PTPRK_pd Subfamily PTPRK 1565-1870 2.4e-70 231.9 In-house 23-296 (314) alignment 
Range on Protein: 1565-1870
Range on HMM: 23-296/314.0
QLDQEFRGLSQGppssntrTDAAQQMANKSKNRFQNIMPYDASRVKLSALPGVVGSDYINASYIDGFRQRKQFIATQGPMQSTLADFWRMVWEQEVHSIV
 . .|.  | .|        |||..  |..|||...|..|| |||.| .. |   ||||||..||.... ..||.||||.|.|..||||.|....  |||
gfkeeyeslfeg.......wdaakkdenreknrsgdilaydrsrvflitidgdpssdyinaalidsykrpaafivtqgPlqetvkdfWrlvydencasiv

MLTHLEESGRQKSEQYWPSLGSDplnVGDLQVSISEEEHKSFGVERTLTLLN--PVSDQAREVKHWQFPNWPSSGEMGSGRDLVDLVMRVEDYARSkvvv
|||.| | || |  .|||  ..     ||..| . | | ..  | |.... .     .. |||...|| .||. .   | . |..|| ||.         
mltelvevgrvkClkyWPedtev...ygdikvelvetellaelvvrifrveklargqeeirevrqfqflgWpdhdvPvsatgllklvrrvkksqee....

pqeesiygnreainehailqQLKPTVVHCSAGVGRTGAYCAAVICLERMKQENKVDLYQVTKHLRTQRPGMVQTAEQYAFVYRVILDYLDKQNGAGPMAA
                    .  ..||||||| ||||...|  | |. ...|. ||.... | ||.... ||.| ||| |.| |||.     . | |.. 
....................eaGrivvhCsaGaGrtGtfiaidivldmieregvvdvfnavktlrsrkvnmveteeqykfiydvileaclcgetaipvse

MESMYATP
....|   
fkalyles
subfamily_PTPN6_pd Subfamily PTPN6 1541-1855 2e-69 229.0 In-house 2-301 (306) alignment 
Range on Protein: 1541-1855
Range on HMM: 2-301/306.0
TEMSPETLRKHFDELRKPV-SSGGTQLDQEFRGLSQGPPSSNTRTDAAQQMANKSKNRFQNIMPYDASRVKLSaLPGVVGSDYINASYIDGF--RQRKQF
|.. ....... .||.|   | . . . .||  |.|   ..    . .... ||.|||..||.|.| .||.|.  |.|.|||||||.||..    ..|..
tsllakeieqrvselekeeeslekagfeeefeelqqeeakkllsrkegakpenkeknryknilPfDhtrvilk.epsvpgsdyinanyikkevkgsdksy

IATQGPMQSTLADFWRMVWEQEVHSIVMLTHLEESGRQKSEQYWPSLGSDPLnVGDLQVSISEEEHKSFGVERTLTLL-NPVSDQAREVKHWQFPNWPSS
||||| ...|..|||||||... . |||.|.  | |..|  .|||.  ...   |...|.  .|....  . |.|..  .  ....||| ...| .||  
iatqgclettvsdFWrmvwqensrvivmttkevErgkekCarYWPdeeekee.yGkisvtnvseksladYilRelsvskkkkkkeerevfqyhfksWPdh

GEMGSGRDLVDLVMRVEDYARSKVvvpqeesiygnreaineHAilqQLKPTVVHCSAGVGRTGAYCAAVICLERMKQ---ENKVDLYQVTKHLRTQRPGM
|   .   ..|... |.  ...                   .|   .  |.|||||||.||||..    | |. ...   . ..|.... | .|.|| |.
gvpkdpgavLdfledvnrkqeele.................ea...eagpivvhCsaGiGRtGtfiviDillkliekkgldadidiqklvksvreqrsgl

VQTAEQYAFVYRVILDYLDKQN
|||..|| |||..|  |.....
vqteqqykfvykaikkyietkk
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 1586-1853 9.4e-68 223.1 In-house 3-244 (250) alignment 
Range on Protein: 1586-1853
Range on HMM: 3-244/250.0
AAQQMANKSKNRFQNIMPYDASRVKLSALPGVVGSDYINASYIDGFRQRKQFIATQGPMQSTLADFWRMVWEQEVHSIVMLTHLEESGRQkSEQYWPSlg
 |....|| |||. .|...| ||| |    |   |||||||...|...|| |||||||.|.|. ||||||.|... .||||| |.||...  .||||   
vakkpqnkeknryadiialdssrvvLekekgdkesdyinasflhgyderkafiatqgPlqatiedfWrmvleeksgtivmLtnLkesekt.yhqywPv..

SDPLNVGDLQVSISEEEHKSFGVERTLTLLNPVSDQAREVKHWQFPNWPSSGEMGSGRDLVDLVMRVEdyarskvvvpqeesiygnreAINEHAilqQLK
  . . ||..||. ..|...  . |.| | .    . | |.. .| .||  |     .  ..|. .|.                    | ...|   . .
ekaekyGdvtvsllskeefadytkrklklskakkaderivrqlhfvvWPdkgvPevatavLellkkvq....................asqqqa...gna

PTVVHCSAGVGRTGAYCAAVICLERMKQENKVDLYQVTKHLRTQRPGMVQTAEQYAFVYRVILDYLDK
| .|.|||||||.||..|    |||.|.|..||...| | ||..||..|.. ||| |||..|| .|| 
PvivqCsaGvgrsGafiaidavlerlkkekvvdvfkvikvlrkdrphavesleqyvfvyeiilkalds
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 1264-1552 1.6e-67 222.8 In-house 8-295 (439) alignment 
Range on Protein: 1264-1552
Range on HMM: 8-295/439.0
NTVIQQMAANSDFAFSEEYECIESGSEF-GR--NYAIMDRNRQKNRFANILAYDHSRVPLHKLPNDPYSDYINANYIDGYNQPKSYIAAQGPLPHTLMDF
.  ....  | .  |.|..| |.| |       . |  . .. |||. .. |.||.|| |...|  |.| |||||||.|| ..| |||.|||  .|  ||
qehvekldknkqeifkeifekinstspdyaciaslaaqeydqtknrykdvgafdhtrvtlqeipgvphshyinanyikGyyddklyiatqgpkkettddf

WRMIWEQRVSVIVMVTNLEEKGRtkchrYWPEEvgGQLpLTTNMSVFMTKQEEFPDMVIRHLTVQ----VSQQSRVVTQFHYISWPDHGVPDSTAGILTT
||...|.... |||.||| |  .     ||| .  ..     ...| . .. |.|. ||| . |      ... | | |||||.|||. ||  .. .|  
wrlviekktvtivmltnlvesyk.....ywpsd..aev.cygdiavrvdrnielpnyvirgfkvfnerdttekertvlqfhyiawpdknvpaqashvldf

IRRAKETRNQAAAGPMVVHCSAGVGRTGTLIAIDYNLDKAASENKVDVMGSLNEMRRQRTTMVQTEGQYIFIYRALADGLSNIVTEMSPETLRKHF
.|  . . ..   ||.|||||||||||||.||.|  |..  .|||||. | .. .|.||. |||.  ||.||| |. . .    . .. . ..|.|
lrainsandkeeygpvvvhcsagvGrtGtiialdialeqlklenkvdikgivkvlrkqrkqmvqalcqyvfiynavledivyGdiavtidefkkef
subfamily_PTPN12_pd Subfamily PTPN12 1581-1854 3e-67 221.5 In-house 29-280 (290) alignment 
Range on Protein: 1581-1854
Range on HMM: 29-280/290.0
NTRTDAAQQMANKSKNRFQNIMPYDASRVKLSALPGVVGSDYINASYIDGFRQRKQFIATQGPMQSTLADFWRMVWEQEVHSIVMLTHLEESGRQKSEQY
  .|.|.... |. |||...|.||| |||.||   .. |||||||..| |  .....||.|||.  || |||||.||..|. .||. .. | |..| |.|
vysteagekeenvkknrykDilPydksrvelskieeeegsdYinanfikgvegkleyiaaqgPLpktlddfWrmiweknveivvmaCrevelgkkkCerY

WPSLGSDPLNVGDLQVSISEEEHKSF-GVERTLTLLNPvsDQAREVKHWQFPNWPSSGEMGSGRDLVDLVMRVEDYARskvvvpqeesiygnreaineha
||. | ..|..|...|. .||.. .   . |||.. .   .. |.|. ... .||  |   |  .|..|.  |... .                      
WpeegeeelefgefevtleeekavdddflirtLkveaq..kesrkvyqfhYtaWPDhgvPssaksllelielvrelqe......................

ilQQLKPTVVHCSAGVGRTGAYCAAVICLERMKQENK---VDLYQVTKHLRTQRPGMVQTAEQYAFVYRVILDYLDKQ
  .. .| ||||||||||||. .|  .  | .|.|.    .|....  .||.||. .||| ||| .||. ..... |.
..sedaPlvvhCsaGvGrtGtiiaidyvrellkaekipeeldvfdlvlelrkqraalvqtkeqyelvykavaelvqke
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 1562-1853 6.3e-67 220.5 In-house 18-285 (290) alignment 
Range on Protein: 1562-1853
Range on HMM: 18-285/290.0
GGTQLDQEFRGLSQGppSSNTRTDAAQQMANKSKNRFQNIMPYDASRVKLSALPGV--VGSDYINASYIDGFRQRKQFIATQGPMQSTLADFWRMVWEQE
| ..  ..|  | .|  .|.  .  .    || .|||.||..||  |. |  ..|      .||||.||.|....||.||||||...||.|||...|...
gnegfrnqfkmldsg..esehtvtvgltssnkllnRfanivvyddnritLrpisghkDCtneyinAcyikgykekkqyiatqgpvsntlvdFWkliwqek

VHSIVMLTHLEESGRQKSEQYWPSLGSDPlnVGDLQVSISEEEHKSFGVERTLTLLNPVS-DQAREVKHWQFPNWPSSGEMGSGRDLVDLVmrvedyars
|  |||||.  |.|..|  ||||. ...   .|  .. ...||. .  .||.| . |  | .....|...|. ||.| |..      . ..         
vtiivmltniieegkvkCqqYWpdsdtka..ygefsikllneetlneyierklevknknsagakqsvtqyqitnwdstgkvtnpqtillvi.........

kvvvpqEESIYGNREAINehailqqlKPTVVHCSAGVGRTGAYCAAVICLERMKQENKVDLYQVTKHLRTQRPGMVQTAEQYAFVYRVILDYLDK
      || .  .|   |        .. |||||..|||.. .||| . ....|.|  .|..|| |..|.|.||.|||..|| ......| |||.
......eemyktqrkrgn........tsivvHCSdtvgrsavfcaaattinkcktegvidvfqvlksqRiqkpgsvqtvqqyqgifqivltylds
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 1581-1853 9.6e-67 219.9 In-house 17-270 (274) alignment 
Range on Protein: 1581-1853
Range on HMM: 17-270/274.0
NTRTDAAQQMANKSKNRFQNIMPYDASRVKL-SALPGVVGSDYINASYIDGFRQ-RKQFIATQGPMQSTLADFWRMVWEQEVHSIVMLTHLEESGRQKSE
|  ..  . . ...|||...|.| . ||| | |. .    |.|||| || |...  | ..|||||...|.||||||....||. |||||.|.|. .|| .
nfdqeeldvfgsqtknryktilPnensrvllesessededssyinanyikGydeeskayvatqGPlpntvadfWrmiyqeevqvivmltklkeaneqkCa

QYWPSLGSD--PLNVGDLQVSISEEEHKSFGVERTLTLLNPVSdqAREVKHWQFPNWPSSGEMGSGRDLVDLVMRVedyarskvvvpqeesiygnR----
.|.|   .     . ||... ...  ..     |.|.|..  .   |.|||. ...||      . . |.|||. |                   .    
vyfPdaedyeiserygdveikvekiverndysvrklvlkyler..ersvkhywytdWPdhksPddantlldlvlev...................eesre

--------EainehailqqlkptVVHCSAGVGRTGAYCAAVICLERMKQENKVDLYQVTKHLRTQRPGMVQTAEQYAFVYRVILDYLDK
                       |||||||.||||.. |. |.. ....|..||. ... .|| .| |||||.||| ...|..  || .
eenaklapv..............vvhCsaGiGrtGcfiaisiavrqlreeivvdvlkivcnlrldrGGmvqtseqyelihralclylkr
0037934 (Phosphotyrosine protein) phosphatases II 1587-1850 2e-66 219.3 In-house 5-241 (243) alignment 
Range on Protein: 1587-1850
Range on HMM: 5-241/243.0
AQQMANKSKNRFQNIMPYDASRVKLsalPGvvgSDYINASYIDGFrqrKQFIATQGPMQSTLAD----FWRMVWEQEVHSIVMLTHLEESGRQKSEQYWP
|. ..|.||||...|.||| |||||   .|   ||||||..|...   ...||||||...|..|    ||||.||. ...|||||.|.| ||.| .||||
allpenlsknrysdilpydhsrvkl...eg...sdyinanliyvt...prliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywp

slgsDPLNVGDLQVSISEEEHKSFGVERTLTLLNPV-SDQAREVKHWQFPNWPSSGEMGSGRDLVDLVMRVEDYARSKVVVPqeesiygnreainehaIL
    .. . ||..| . .|||..  . |||.| |.  .|. |.| |... .||  |   |  ||.|..  | .. .. . .                  |
....gevtygdftvtllseehlddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsll................al

QQLKPTVVHCSAGVGRTGAYCAAVICLERMkqenKVDLYQVTKHLRTQRPG-MVQTAEQYAFVYRVILDY
 . .|..|||||||||||...|| ..|...    .|||... |.||.|||| .||| .|| |.|...| .
dsggpvlVHCsaGvgRtGtliaaylmllll....gvdleeavkllreqRpgkavqtpsqyrflyeallel
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 1564-1854 6.1e-66 217.4 In-house 15-279 (281) alignment 
Range on Protein: 1564-1854
Range on HMM: 15-279/281.0
TQLDQEFRGLSQGPpsSNTRTDAAQQMANKSKNRFQNIMPYDASRVKLSALPGVVGSDYINASYIDGFRQRKQFIATQGPMQSTLADFWRMVWEQEVHSI
. . .|...|..     .  . |... .|. |||..||. |||.|||..       .|||||....|... |..||||||. ..|..||.|||||.|. |
aGfieeyeklaaig..vdntataskadenvlknrYsnivaYDatrvkvtpneenkntDYinanfvpgykgekeyiatqgPvPaslvafWqmvweqkvsai

VMLTHLEESGRQKSEQYWPsLGSDPLNVGDLQVSISEEEHKSFGVERTLTLlNPVSDQAREVKHWQFPNWPSSGEMGSGRDLVDLVMRVEDYARSKVVvp
||.|.  |.|. |  .|||  ..  |..||..|.  .||.|.  .||...| .  | ..|||.. .. .||  |   . ..|..    |. . ..|    
vmvtreieagklkChrYWP.ddnselkygdvtvkstaeeekatyierkfkl.eresgetreveqlaytaWPdhGvPattkellefrkevlkltekktk..

qeesiygnreainehailqqlKPTVVHCSAGVGRTGAYCAAVICLERMKQE-NKVDLYQVTKHLRTQRPGMVQTAEQYAFVYRVILDYLDKQ
                      | |.||||||||||.| |    ......| ...|. .| ..|| .|  ||||  ||.|||...||.|||.
.....................aplvihCsaGvGrtGtyialDrlvkaveaeleeldvkavvaelrkernlmvqtvvqyefvykavldaldke
subfamily_PTPN1_pd Subfamily PTPN1 1284-1545 1.1e-65 216.3 In-house 15-280 (290) alignment 
Range on Protein: 1284-1545
Range on HMM: 15-280/290.0
CIESGSEFGRNYAIMDRNRQKNRFANILAYDHSRVPLHKLPNdpysDYINANYIDGYNQPKSYIAAQGPLPHTLMDFWRMIWEQRVSVIVMVTNLEEKGR
. .  |.|  . | ...||..||. ..  |||||. |..  |    |||||. ..  .  .||| .|||||.|   ||.|.|||.   .||. .. ||..
irkeasdfptreaklpenrnlnryrdvspydhsrikleradn....dyinaslveleeakrsyiltqGPlpntvdhfWqmvWeqkskavvmlnkvvekeq

TKCHRYWPEEVG-GQLPLT-TNMSVFMTKQEEFPDMVIRHLTVQV--SQQSRVVTQFHYISWPDHGVPDSTAGILTTIRRAKETRN-QAAAGPMVVHCSA
.||..|||..    .| |  |...| . ..|.    ..|.| ..   .|..|....|||..||| |||.| |  |  . . .|.   .   || |.||||
ikcaqywPqgeeekellledtklkvkliseerksyytvrllelenlktqetreilhfhyttwpdfgvpespaaflkflfkvresGslssdvGpavihcsa

GVGRTGTLIAIDYN---LDKAASENKVDVMGSLNEMRRQRTTMVQTEGQYIFIYRALADGLSNIVTEMSP
|.||.||.. .|     ..|    . ||.   | |.|..|. ..||  |  | | |. .|   | .. | 
GiGrsGtfclvdtclvliekkddlssvdikkvllelrkyrlGliqtadqlrfsylaileGakvikgdssv
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 1301-1532 2.5e-65 215.0 In-house 7-236 (239) alignment 
Range on Protein: 1301-1532
Range on HMM: 7-236/239.0
NRQKNRFANILAYDHSRVPLHKLPNDPYSDYINANYIDGYN-QPKSYIAAQGPLPHTLMDFWRMIWEQRVSVIVMVTNLEEKGRTKCHRYWPEEVGGqlp
|. |||.|||..|||||| | || |||.||||||.|.  |.  ||.|||.|| .  .  |||||.|..|  ||||.| | |  . |||.|||.       
nkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdstsk...

lTTNMSVFMTKQEEFPDMVIRHLT-VQVSQQ-SRVVTQFHYISWPDHGVPDSTAGILTtIRRAKETRNQAAAGPMVVHCSAGVGRTGTLIAIDYNLDKAA
   |. | . | | | | .|| .   || |   | | |.|.  |||.|||. .. .|  .||     .   | | |.||||||||||... ||  | .| 
.ycnlrvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlg.lrrkitkdslpgarpwvihcsagvgrtgaflvidamlrqak

SENKVDVMGSLNEMRRQRTTMVQTEGQYIFIYRAL
 .. ||..  .. .| .|  ||||  ||.||. |.
kqktvdifnyvkairedrphmvqtseqyvfihlav
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 1301-1532 2.8e-65 214.8 In-house 8-237 (239) alignment 
Range on Protein: 1301-1532
Range on HMM: 8-237/239.0
NRQKNRFANILAYDHSRVPLHKLPNDPYSDYINANYIDGYN-QPKSYIAAQGPLPHTLMDFWRMIWEQRVSVIVMVTNLEEKGRTKCHRYWPEEVGGqlp
|. |||.|||..|||||| | || |||.||||||.|.  |.  ||.|||.|| .  .  |||||.|..|  ||||.| | |  . |||.|||.       
nkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdstsk...

lTTNMSVFMTKQEEFPDMVIRHLT-VQVSQQ-SRVVTQFHYISWPDHGVPDSTAGILTtIRRAKETRNQAAAGPMVVHCSAGVGRTGTLIAIDYNLDKAA
   |. | . | | | | .|| .   || |   | | |.|.  |||.|||. .. .|  .||     .   | | |.||||||||||... ||  | .| 
.ycnlrvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlg.lrrkitkdslpgarpwvihcsagvgrtgaflvidamlrqak

SENKVDVMGSLNEMRRQRTTMVQTEGQYIFIYRAL
 .. ||..  .. .| .|  ||||  ||.||. |.
kqktvdifnyvkairedrphmvqtseqyvfihlav
subfamily_PTPN23_pd Subfamily PTPN23 1553-1853 8.7e-65 213.4 In-house 4-282 (288) alignment 
Range on Protein: 1553-1853
Range on HMM: 4-282/288.0
DELRKPVSSGGTQLDQEFRGLSQGPPSSNTRTDAAQQMANKSKNRFQNIMPYDASRVKLSalpgVVGSDYINASYIDGFRQ-RKQFIATQGPMQSTLADF
 ||.. . .| |.||..|. | |     .  .  |    . .|||...|.||| .||||         ||||||.. .      .|||||.|.||||.||
eelqrkmldgktaldkkfkeleqkqdkearkrsiaiaklyseknrsrdilPyDhnRvklr....gskDDYinAsfvkdlspgcPdfiatqaPlqstlnDF

WRMVWEQEVHSIVMLTHLEESGRQKSEQYWPSLGSDPLNVGDLQVSISEEEHKSFGVERTLTLLNPVSDQAREVKHWQFPNWPSSGEMGSGRDLVDLVMR
|.||.|| .  ||||.. || |..| ..|||.   .. . |||.|....... .  |||.|.|    .|. ..|.| |. .||. |   |  .|....  
WlmvyeqkssviVmllskeelgkpkvdrYwPedkgetvkfgdlsvtlksvretethvervlkletldadavksvshlqltsWpelGvPasPetllqflde

VED-YARSKVVVPQeesiygnreainehailqqlkPTVVHCSAGVGRTGAYCAAVICLERMKQENK-VDLYQVTKHLRTQRPGMVQTAEQYAFVYRVILD
||. |   .  . .                     | ||||||||||||...  .  .. ....|  .|. || ..||.||  |||. ||. |.| ..| 
vesayeavqrkskt.....................PlvvhCsaGvgRtgvfalvyaavrelekgnglldiiqvvsrlreqRrfmvqekeqlkfsyeavle

YLDK
.  .
aarr
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 1567-1854 3.2e-64 211.7 In-house 23-281 (287) alignment 
Range on Protein: 1567-1854
Range on HMM: 23-281/287.0
DQEFRGLSQGPPSSNTRTDAAqQMANKSKNRFQNIMPYDASRVKLSalpgVVGSDYINASYIDGFRQRKQFIATQGPMQSTLADFWRMVWEQEVHSIVML
 . |  | |   . .  | .     || |||...|...|  || |         |||||..|||....|.||....|| .|. .||.......|. ||||
knqftvleqvtqredevthni.asqnkdknRltqilvpdnyrvllk....gehpdyinavfidgykekkafiiaesPmfntarnfWkliddrnvtaivml

THLEESGRQKSEQYWPSLGSdpLNVGDLQVSISEEEHKSFGVERTLTLLNPVSDQA-REVKHWQFPNWPSSGEMGSGRDlvdLVMRVedyarskvvvpqE
....|. ...  ||||.  |  . .|. .... .||...  .||.| . |  .... ..|| .|. ||.| |.. . .     .. .            |
cqekendeevcyqyWpeeks..vvlGeyniellneevnagyierklevknknkagdkqqvkqyqitnWdstgkvtepqt...illvi............e

ESIYGNREAINehailqqlKPTVVHCSAGVGRTGAYCAAVICLERMKQENKVDLYQVTKHLRTQRPGMVQTAEQYAFVYRVILDYLDKQ
| .  .|   |         . |||||..|||.. .||| . ... |.|  .|..|| |. | |.||.|||.||| |.. ..| |||  
emyktqrkrgn........tsivvhCsdtvGrsamfcaaattinkckteGviDvfqvlksqriqkpgsvqtveqykfindivleyldsf
subfamily_PTPN3_pd Subfamily PTPN3 1581-1850 5.5e-64 210.8 In-house 30-274 (280) alignment 
Range on Protein: 1581-1850
Range on HMM: 30-274/280.0
NTRTDAAQQMANKSKNRFQNIMPYDASRVKLSALPgvVgsDYINASYI----DGFRQRKQFIATQGPMQSTLADFWRMVWEQEVHSIVMLTHLEESGRQK
.  ..||.. .| ||||...|.|||| ||||.. .  .  |||||.|.    ..  . ...||||||...| .|||.|||||... ||||| | |.||.|
glaisaarkpenlsknryrdilpydatrvklkese..t..dyinanyvnmeipstglvnryiatqGPlaktatdfWqmvweqksslivmlttlverGrvk

SEQYWPSlGSDPLNVGDLQVSISEEEHKSFGVERTLTLLNPVSDQAREVKHWQFPNWPSSGEMGSGRDLVDLVMRVEDYArskvvvpqeesiygnreain
  ||||.  .| |. |...| ...|....  | | |.| .  ... |.. . |. .|| .|   .  |....| ||...                     
ChqyWPe.tedeleygefsvkcekedetksyvlrelvlkdketkeerkilqlqylaWpdhgvPddsadflefvervrklr....................

ehaiLQQLKPTVVHCSAGVGRTGAYCAAVICLERMKQENKVDLYQVTKHLRTQRPGMVQTAEQYAFVYRVILDY
      . .|.|||||||.|||| . .  ..|  . ....|   .. ...| ||  .||||.|| ||   ||  
....sgkeePvvvhCsaGigrtGvlilletalalieaaepvypldivrtmrdqramlvqtasqykfvCeailkv
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 1547-1756 1.6e-63 209.7 In-house 6-208 (318) alignment 
Range on Protein: 1547-1756
Range on HMM: 6-208/318.0
TLRKHFDELRKpvsSGGTQLDQEFRGLSQGPpSSNTRTDAaQQMANKSKNRFQNIMPYDASRVKLSALPGVVGSDYINASYIDGFRQRKQFIATQGPMQS
 |..|  .||.   || ..|..|.  ||. . .. |....  . .|| |||..||..|| .||||. | |..|||||||.||||.|..|..||.|.|.  
dleshvrrlre...sGelllseeyerlsrse.etvtslks.lepvnkaknryanilaydhtrvkLqmlegeegsDyinanyidGyrrkkayiaaqaPlpe

TLADFWRMVWEQEVHSIVMLTHLEESGRQKSEQYWPSLGSdpLNVGDLQVSISEEEHKSFGVERTLTLLNPVSDQAREVKHWQFPNWPSSGEMGSGRDLV
|. |||||||||.   |||||..||.|..| ..|||| ||   . |.|.| ..|| . |  | |.... .  ... |.|. ... .|| .|   || .|.
tieDfWrmvWeqnsavivmltqeeergkakvhryWPskgs..rsygklvvelkeevelsdyvlrefkvtrteeeesrqvrqyhytsWpdegvpesgasll

DLVMRVEDYA
||| .|. . 
dlvrqvskaq
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 1268-1534 3e-62 205.0 In-house 7-291 (301) alignment 
Range on Protein: 1268-1534
Range on HMM: 7-291/301.0
QQMAANSDFAFSEEYECIESGSEFGRNYAIMDRNRQKNRFANILAYDHSRVPLHKLPN--DPYSDYINANYIDGYNQPKSYIAAQGPLPHTLMDFWRMIW
...||.    |.|.|. ...|..   .  . ..|.. ||| ||  ||. |. |.. ||      .||||.|||||.. | .||||||. .||.||||.||
thvaakhsnkfeeqykelkegedksctvglseenkalnrfknitvyddnriilkpkpnldlcqreyinasyidgysekkkfiaaqgpmkktlvdfWrliw

EQRVSVIVMVTNLEEKGRTKCHRYWPEEVGGQLpLTTNMSVFMTKQEEFPDMVIRHLTVQVSQ-----------------QSRVVTQFHYISWPDHGVPD
..... |||||||.|. ..||..|||.    .     ...| ....  .||.|||.|.|.. .                 .|. |.|.. ..||..||  
qekpvsivmvtnlkegtkskceqywpnseaese.efgpftvtlvneqvyPdfvirqlnvkiqdgsnngyierkfkvksdksswdvlqlqvtdWpqdGvvr

STAGILTTIRRAKETRNQAAAGPMVVHCSAGVGRTGTLIAIDYNLDKAASENKVDVMGSLNEMRRQRTTMVQTEGQYIFIYRALAD
  . .|  |     ....   ||.|||||..|.|.|. ....  |. . .|  |||..  . .||..  .|.|  ||..|| ..  
eprtvLqviddvihrqqkigggpvvVHCSdtVsrsGvYcsvsiglEQckaegVVdvfqvtkavrrskpgaVtTLeqytsiydvidm
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 1300-1532 4.3e-62 204.4 In-house 2-235 (237) alignment 
Range on Protein: 1300-1532
Range on HMM: 2-235/237.0
RNRQKNRFANILAYDHSRVPLHKLPNDpySDYINANYIDGYN-QPKSYIAAQGPLPHTLMDFWRMIWEQRVSVIVMVTNLEEKGRTKCHRYWPEEvgGQL
.|. |||..|| ||||||| |.   ..  ||||||.|..|..  ||.||||||||  .  |||.|.|... |||||.| | |. . |||.|||.    | 
enkiknrygnivaydhsrvvlkgagsg..sdyinatylkgfdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywpst..dqp

PLTTNMSVFMTKQEEFPDMVIRHLTVQVS---QQSRVVTQFHYISWPDHGVPDSTAGILTTIRRA-KETRNQAAAGPMVVHCSAGVGRTGTLIAIDYNLD
     ..| ..|.||| |  .| |....    .. |.. |... ||||.|||. || .|   ..  ....  . .|| ..|||||||||| .. ||  | 
aaygvltvslkkkeefsdytvrslllskrltlkevrlihqyqftswpdrgvpqqtaallrfrkniinrsphvsesgpwiihcsagvgrtgiflvidamlr

KAASENKVDVMGSLNEMRRQRTTMVQTEGQYIFIYRAL
.|  .. ||.   .  .  .|  ..||. ||.||....
qakekkvvdiynyvysieedrpyiiqtkdqyvfihqti
subfamily_PTPN14_pd Subfamily PTPN14 1280-1536 1.8e-61 202.7 In-house 27-296 (300) alignment 
Range on Protein: 1280-1536
Range on HMM: 27-296/300.0
EEYECIESGSEFGRNY-AIMDRNRQKNRFANILAYDHSRVPLHKLPNDpYSDYINANYIDGY--NQPKSYIAAQGPLPHTLMDFWRMIWEQRVSVIVMVT
 ||| |   .| .  . | .. | .|||| ..| |...|| |    ..  ..||||  |      . .|||.|||||..|. |||.|.||| |..|||.|
teyeripkkredallstaklpenaeknrfkdvlPyednrvelsptken.stgyinassikvsvggkersyivaqgPleltvqdfWqmvWeqgvqlivmlt

NLEEKGRTKCHRYWPEEVGGQLPLTTN-MSVFMTKQEEFPDMVIRHLTVQ--VSQQSRVVTQFHYISWPDHGVPDSTAGILTT------IRRAKETRN--
. ||.|..|...|.|..   .  .. .   |    .|. . .. . |...   |.. | |  . |. |||||||.   | |        .||. .. .  
eeeedgkeksfkyfPkleskkktvefgkfkvttkfsedsdsvittglklkhlpskeertvwhlqytDWpdhgvPeDvkgflsyLeevqsvrrktnseves

QAAAGPMVVHCSAGVGRTGTLIAIDYNLDKAASENKVDVMGSLNEMRRQRTTMVQTEGQYIFIYRALADGL
. .  |..||||||||||| ||  |  .     ....|.  .|. .|.|| ..||| .|| |.|..|   |
keskPPvlvhCsaGvGrtGvlilsdlliatlehneeidikkvlarLreqrmllvqtlaqYkfvYkvlikyl
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 1564-1852 2e-60 199.0 In-house 15-294 (301) alignment 
Range on Protein: 1564-1852
Range on HMM: 15-294/301.0
TQLDQEFRGLSQGppsSNTRTDAAQQMANKSKNRFQNIMPYDASRVKLSALPG--VVGSDYINASYIDGFRQRKQFIATQGPMQSTLADFWRMVWEQEVH
........ |..|   .. ...   . .||  |||.|| .||  |. |.  |   .   .|||||||||....|.|||.||||..||.||||..|.. . 
nkfeeqykelkeg...edksctvglseenkalnrfknitvyddnriilkpkpnldlcqreyinasyidgysekkkfiaaqgpmkktlvdfWrliwqekpv

SIVMLTHLEESGRQKSEQYWPSLGSDPLNVGDLQVSISEEE-HKSFGVeRTLT-LLNPVSDQAREVKHWQFPNWPssgemgSGRDLVDLvmRVEDYARSK
||||.| |.|. ..|.|||||.   .  ..| ..| ...|  . .| . | |.  .. .|....  ....  .        |..|.. |   | |.    
sivmvtnlkegtkskceqywpnseaeseefgpftvtlvneqvyPdfvi.rqlnvkiqdgsnngyierkfkvksdk......sswdvlql..qvtdWpqdG

VVVPQEESIYGNREAINEHAILQQlKPTVVHCSAGVGRTGAYCAAVICLERMKQENKVDLYQVTKHLRTQRPGMVQTAEQYAFVYRVILDYLD
||  .   .    . |          | |||||..|.|.| ||.  | ||  | |  ||..|||| .| ..||.|.| ||| ..| ||  || 
vvreprtvLqviddvihrqqkigg.gpvvVHCSdtVsrsGvYcsvsiglEQckaegVVdvfqvtkavrrskpgaVtTLeqytsiydvidmylq
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 1299-1533 8.9e-60 196.9 In-house 36-274 (287) alignment 
Range on Protein: 1299-1533
Range on HMM: 36-274/287.0
DRNRQKNRFANILAYDHSRVPLHKLPNDpYSDYINANYIDGYNQPKSYIAAQGPLPHTLMDFWRMIWEQRVSVIVMVTNLEEKGRTKCHRYWPEEvGGQL
  . .|||.|..| .|..|| | . ..   ||||||||. .|.. ...||||||.. |. ||||...|.|.......|   |..| ||..||||     .
laavkknryadvlPiddtrvllsaegel.GsdyinanyvasytddeafiaaqgPiaatvrdfwravletrsasvitmtreveearlkcykywPer.evPm

PLTTNMSVFMTKQEEFPDMVIRHLTVQV-S-QQSRVVTQFHYISWPDHGVPDSTAGILTTIRRA----KETRNQAAAGPMVVHCSAGVGRTGTLIAIDYN
 .     | . ..   |.  .| | .     ...||| |....||||.... .. |..  .       . .|. . .||.|||...|.||.|.|.|.   
rvGGysvvlldydikePeygvralrlidletrearvvkqldllswPdkvlaPtavglirfvldvkqhielardasevGPlvvhddvGiGrsGillatlvl

LDKAASENKVDVMGSLNEMRRQRTTMVQTEGQYIFIYRALA
...  .  .|||   .  .| .|...||.  |. ..| ||.
vsrledlGrvdvaavvirlreyraalvqavvqlrllyealv
subfamily_PTPN23_pd Subfamily PTPN23 1292-1532 2.2e-59 195.6 In-house 34-276 (288) alignment 
Range on Protein: 1292-1532
Range on HMM: 34-276/288.0
GRNYAIMDRNRQKNRFANILAYDHSRVPLHklpnDPYSDYINANYIDGYN-QPKSYIAAQGPLPHTLMDFWRMIWEQRVSVIVMVTNLEEKGRTKCHRYW
.|  ||  .. .|||. .|| |||.|| |.    .   ||||| .. .   .  ..||.|.||. || |||.|..||..|||||... ||.|..|..|||
krsiaiaklyseknrsrdilPyDhnRvklr....gskDDYinAsfvkdlspgcPdfiatqaPlqstlnDFWlmvyeqkssviVmllskeelgkpkvdrYw

PEEVGgQLPLTTNMSVFMTKQEEFPDMVIRHLTVQVSQQS--RVVTQFHYISWPDHGVPDSTAGILTTIRRAKE---TRNQAAAGPMVVHCSAGVGRTGT
||. | .     ..|| . ...| . .| |.|.... ...  . |.  .. |||..|||.|   .|  .  ...   .... .  |.||||||||||||.
Pedkg.etvkfgdlsvtlksvretethvervlkletldadavksvshlqltsWpelGvPasPetllqfldevesayeavqrksktPlvvhCsaGvgRtgv

LIAIDYNLDKAASENK-VDVMGSLNEMRRQRTTMVQTEGQYIFIYRAL
.  .   . .   .|  .|..  .. .|.||  |||.. |. | | | 
falvyaavrelekgnglldiiqvvsrlreqRrfmvqekeqlkfsyeav
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 1584-1849 8.4e-59 194.0 In-house 41-277 (315) alignment 
Range on Protein: 1584-1849
Range on HMM: 41-277/315.0
TDAAQQMANKSKNRFQNIMPYDASRVKLSALPGVVGSDYINASYIDGFRQRKQFIATQGPMQSTLADFWRMVWEQEVHSIVMLTHLEESGRQKSEQYWPS
 | |... || |||. ||..|| |||.|  |    .|||.||..|||. .....||.|||  ... ||||.|.|...  ||||| | |  ..|.|.||| 
ldvakkienkqknryiniiaydksrvqlpllendphsdyvnanfidGynkkrryiaaqgpnvasvkdfwrlvfeedigkivmltnlvegekrkaekywpd

LgsdPLNVGDLQVSISEEEHKSFGVERTLTLLnpVSDQAREVKHWQFPNWPSSGEMGSGRDLVDLVMRVEDYARSKVvvpqeesiygnreainehailqq
     .  | . |.  .||...    |||.    . |. |||  ...  || .|   .   |..|. .|  .  ..|                       
k...kviyGkitvtrkseevnteytvrtlsvv..fgdnirevvqlhytswpdmgvpkytiplmnlirtvkqhhtnsv.......................

lKPTVVHCSAGVGRTGAYCAAVICLERMKQENKVDLYQVTKHLRTQRPGMVQTAEQYAFVYRVILD
  . ||||||||||||....    |.... || .|.|.. . .| .| .|||.|||| |.| ..|.
.gaivvhcsaGvGrtGtfitldavldqaeaenaidvynfitgvrqnrikmvqvaeqyqfiydalle
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 1583-1853 8.5e-59 193.7 In-house 11-266 (270) alignment 
Range on Protein: 1583-1853
Range on HMM: 11-266/270.0
RTDAAQQMANKSKNRFQNIMPYDASRVKLSALPGVVGSDYINASYIDGFRQ-RKQFIATQGPMQSTLADFWRMVWEQEVHSIVMLTHLEESGRQKSEQYW
..|  ..  .|  ||...|.|  |.||.|. |     . |||| |. || . .|..||..||...|| .||||.||..|..|||.|.||| ||.| |.||
esdlpeaargkklnRyadiLPsPatRvrleeleedsataYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkgrkkCerYW

PSLGSD--PLNVGDLQVSISEEEHKSFGVERTLTLLnpVSDQAREVKHWQFPNWPSSGemgsgrdlvdlVMRVED-YARSKVVVpqeESIYGNREAINEH
|.   .   |. |...|  ..||.... . . |.|    . . |.. |... .||  |           | | ||   ... ..   . .   |.  .|.
paepkekvkledgkikvlalseekeegyiltrlrle..ekgeerrlvHfwyntWpdhg...........vpreedsslstdqll...kmlravrrsekel

ailQQLKPTVVHCSAGVGRTGAYCAAVICLERMKQENKVDLYQVTKHLRTQRPGMVQTAEQYAFVYRVILDYLDK
   .. .|..|||||||||||   |  |... .....|||. .. ..|| .|. .||. |||.|.|.... | ..
...dkaePllvHcsaGvgRtGtlialDiavrlLeetkkvdvlaiieelRkdRmalvqhpeqyeflykavveyaer
subfamily_PTPRN_pd Subfamily PTPRN 1293-1539 2e-58 192.4 In-house 48-295 (297) alignment 
Range on Protein: 1293-1539
Range on HMM: 48-295/297.0
RNYAIMDRNRQKNRFANILAYDHSRVPLHKLPNDPYSDYINANYIDG-YNQPKSYIAAQGPLPHTLMDFWRMIWEQRVSVIVMVTNLEEKGRTKCHRYWP
.. |  ..| .||| ...|.|||||| |..  ..  ||||||  |     .  .|||.||||..|. |||.|.||| | |||..|.|||.| ..|.||||
kevakaeknvkknrskavlpydhsrvklkeeasaeksdyinasaildhdprapayiatqgplastvadfwqmvweqGvvvivnltrleeegvkqckrywp

EEvGGQLPLTTNMSVfMTKQEEFPDMVIRHLTVQ--VSQQSRVVTQFHYISWPDHGVPDSTAGILTTiRRAKETRNQAAAGPMVVHCSAGVGRTGTLIAI
.| | ..    .. . ...     | ..| . ..   ....| |||||..|||..||| |.  .|   ||  .   .  . |.|||||.|.||||. |.|
de.Gsevyhiyevhl.vsehiwcddylvrsfylknlqtsetrtvtqfhflswpeegvPasaksllef.rrkvnksyrGrscpivvhcsdGaGrtGvyili

DYNLDKAAS-ENKVDVMGSLNEMRRQRTTMVQTEGQYIFIYRALADGLSNI
|  |.. .   ...|.. .|. .| ||. .|.|. |. |.. |.|. . .|
dlvlnrllkGvkeidiaatlehlrdqrpglvktkdqfefaltavaeevnai
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 1545-1755 1.6e-56 186.7 In-house 7-210 (319) alignment 
Range on Protein: 1545-1755
Range on HMM: 7-210/319.0
PETLRKHFDELRKpvsSGGTQLDQEFRGLSQGPPSsntRTDAAQQMANKSKNRFQNIMPYDASRVKLSALPGVVGSDYINASYIDGFRQRKQFIATQGPM
 . |.... .|..   .| |.|..||. |... .     .| |..  ||.|||.|||..|| .||.||.|.|| ||||||||.|||...|..|||||.|.
vqeLkerlkalas...tgetllekefkllkeavnd...tfdsaskeenkkknryqnilaydrtrvvlseldgvegsdyinasfidgyqerekfiatqaPl

QSTLADFWRMVWEQEVHSIVMLTHLEESGRQKSEQYWPSLgsDPLNVGDLQVSISEEEHKSFGVERTLTLlNPVSDQA--REVKHWQFPNWPSSGEMGSG
. |. ||||||||.|.. .||||.| | .. | ..|||.   .. . | | | . |||...  . | |.| |. |..   |||||.|. .||  .   ..
entiedfWrmvWeeessivvmltklveklkvklkkywpee..nfeeyGrlivtleeeeeledyiirklkl.nkkssevetRevkhfqyteWpdhdvPeka

RDLVDLVMRVEDY
. |.||. |..  
tslldllkrirks
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 1275-1555 1.9e-56 186.1 In-house 19-255 (392) alignment 
Range on Protein: 1275-1555
Range on HMM: 19-255/392.0
DFAFSEEYECIESGSEFGRNYAIMDRNRQKNRFANILAYDHSRVPLHKLPNDPYSDYINANYIDGYNQPKSYIAAQGPLPHTLMDFWRMIWEQRVSVIVM
   |.||.  . .   . .. |  . | .|||. ||| || .|| |  . . | |||.|| ||..... |.|||.||| . .| |||||.....|. |.|
salffeefhdlpgpdiypqtvaqkeinlkknryknilpydsarvkleviddipdsdylnasyipsfdnekayiasqgpnaaslddfwrmvfqenvttiam

VTNLEEKGrtkchrywpeevggqlplttnmsvfmtkqeefpdmvirhltvqVSQQSRVVTQFHYISWPDHGVPDSTAGILTTIRRAKETRNQAaAGPMVV
||.|.|                                               .. | |.|||.  |||..||  |. .|  |.  |    |  . |...
vtklkegd...........................................kgddartvaqfhftewPdkdvpkhtssllkfikevkadfGqy.thplii

HCSAGVGRTGTLIAIDYNLDKAASENKVDVMGSLNEMRRQRTTMVQTEGQYIFIYRALADGLSNIVTEMSPETLRKHFDEL
|||||||||| .|.||  . .|     |||.  . ..||.|  ||||. || ||| |. . |    | .    .  | ..|
hcsagvgrtgvvisidsvvahakktrmvdvfnfvtnirrkrpymvqtkeqyafiygavledllwrntlipvvhftdhlqdl
subfamily_PTPN14_pd Subfamily PTPN14 1579-1853 2.6e-56 185.8 In-house 36-298 (300) alignment 
Range on Protein: 1579-1853
Range on HMM: 36-298/300.0
SSNTRTDAAQQMANKSKNRFQNIMPYDASRVKLSALPGVvGSDYINASYIDGF--RQRKQFIATQGPMQSTLADFWRMVWEQEVHSIVMLTHLEESGRQK
. .. ...|.   |..||||....||. .||.||.      ..||||| |      .....|..|||.. |. |||.|||||.|. |||||. ||.|..|
redallstaklpenaeknrfkdvlPyednrvelsptken.stgyinassikvsvggkersyivaqgPleltvqdfWqmvWeqgvqlivmlteeeedgkek

SEQYWPSLGS--DPLNVGDLQVSISEEEHKSFGVERTLTLLNPVSDQAREVKHWQFPNWPSSGemgSGRDLVDLVMRVEDYarskvvvpqeESIYGNREA
| .|.|.|.|  . .. |  .|.    |. .  . ..|.|    | . |.| | |. .||  |     .|. . .  .|.           .|.  . . 
sfkyfPkleskkktvefgkfkvttkfsedsdsvittglklkhlpskeertvwhlqytDWpdhg...vPeDvkgflsyLeev..........qsvrrktns

INEHaiLQQLKPTVVHCSAGVGRTGAYCAAVICLERMKQENKVDLYQVTKHLRTQRPGMVQTAEQYAFVYRVILDYLDK
 .|    ..  | .|||||||||||    . . .. .......|. .| ..||.||  .|||  || |||.|.. ||..
eves..keskPPvlvhCsaGvGrtGvlilsdlliatlehneeidikkvlarLreqrmllvqtlaqYkfvYkvlikylkn
0051429 (Phosphotyrosine protein) phosphatases II 1327-1557 4.2e-56 185.8 In-house 2-245 (272) alignment 
Range on Protein: 1327-1557
Range on HMM: 2-245/272.0
PYSDYINANYIDGYNQ---PKSYIAAQGPLPHTLMDFWRMiWEQRVSVIVMVTNLEEKGRTKCHRYWP---------EEVGGQLPLTTNMSVFMTKQEEF
|.|.||||....||..   |. .....||||.|  ||||. .|.....||.....||.|| ||.||||         .. . . .|  ...|.... | .
plsgyiNardvggygrvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseell

PDMVIRHLTVQ---VSQQSRVVTQFHYISWPDHGVPDSTagILTTIRRAKEtrnqaaAGPMVVHCSAGVGRTGTLIAIDYNLDKAASENKVD--------
.|...|.|..      ...| |...||..|||||||...  .|. ..   .       ||..||||||..||||..|... |     |  ||        
ldyilrellltlllsagearevmhlhytdwpdhgvpqea..llellellld......ggpvlvHCsaGkdRTGtvvallllllgvsletivddYlltnly

VMGSLNEMRRQRTTMVQTEGQYIFIYRALADGlSNIVTEMSPETLRKHFDELRK
. . ..|.|.||  .||||.||.|.|.||..   . ......|.|. ..|....
leeaveelraqrpgavqteeqylflyeallel.lrsllsvraeyllaaldaide
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 1577-1866 5.2e-56 185.1 In-house 33-303 (325) alignment 
Range on Protein: 1577-1866
Range on HMM: 33-303/325.0
PPSSNTRTDAAQQMANKSKNRFQNIMPYDASRVKLSALPGVVGSDYINASYIDGFRQRKQFIATQGPMQSTLADFWRMV--WEqevHSIVMLTHLEESGR
|.       .| . .||.||||.|....| ||| | ..     ||||||||.  ..... |.|.| |. .|. |.||.|  |.    |.|...   . | 
psddgiakkvamkpenkaknrfknvvaldksrvvletkkddpssdyinasylrddkkkdvflaaqaPltatindlWrlvldWr...csvvvvlneldlgk

QKSEQYWPSLGSDPLNVGDLQVSISEEEHKSFGVERTLTLLNPVSDQAREVKHWQFPNWPSSGEMGSGRDLVDLVMRVEDyarskvVvpqEESIYGNRea
..  .|||   ..  . | |.|..   |. |  | | | . ..   ..| || .|.  |.  |       |. ..  |.       |   .| .  |   
drcavywpkemgksktfGglevklrtieeisdyvhrvldvkqvkkGetrsvkqfqlqswddmGvqkrpatlisilqlvka......v...servtant..

inehailQQLKPTVVHCSAGVGRTGAYCAAVICLERMKQENKVDLYQVTKHLRTQRPGMVQTAEQYAFVYRVILDYLDKQNGAGPMAAMESM
       .   | .|||||||||||.. .    |... .| .||.... |.|| .|| ||.|..|| ..|  . ...   |   |....|. 
.......kastpilvhcsaGvGrtGvfislysalakvieesrvdifgfvkklrkdrpsmvetvdqyiliyealveaymsgntdvpvssfeak
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 1582-1849 5.3e-56 184.6 In-house 23-264 (283) alignment 
Range on Protein: 1582-1849
Range on HMM: 23-264/283.0
TRTDAAQQMANKSKNRFQNIMPYDASRVKLSALPGvvgsDYINASYID---GFRQRKQFIATQGPMQSTLADFWRMVWEQEVHSIVMLTHLEESGRQKSE
  .| |    || |||.|.|.|.|  ||.| ...     |||||..|      .| |..|..|.|.. |  |||.||..... .|||||.| |  |.|  
ldadiasadenkrknrnqeivpadqwrvelksesr....dyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfdekitaivmltklqedlrikCs

QYWPSLGSDplNVGDLQVSISEEE-HKSFgVERTLTLLNPVSDQA-REVKHWQFPNWpssgemgsgrdlvdlvmrvedyarskvV----VPQEESI-YGN
||||. ||   . |.. |.. .|  ..|| . . |.| .  | ..   . |.|. .|                           .     .  .|.   |
qyWPkrGse..dyGeftvtlrkettsnsf.iikelllrvnssakstlllahyqvidW...........................leygeqaiinslvkfn

reAINEHAILQQLKPTVVHCSAGVGRTGAYCAAVICLERMKQENKVDLYQVTKHLRTQRPGMVQTAEQYAFVYRVILD
   .      ..  | |||||.|.|||....||.  .. .. |  ||...| | .| ||...||| .|| .|. ..|.
..kvislqteskkgPivvhCstgiGrtavfiaasasvkdaltesvvdvfavvkimreqrmmavqtldqyklvhelvle
subfamily_CG7180_pd Subfamily CG7180 1299-1533 5.4e-56 184.4 In-house 40-287 (296) alignment 
Range on Protein: 1299-1533
Range on HMM: 40-287/296.0
DRNRQKNRFANILAYDHSRVPLHKLPNDPYSDYINANYIDGYNQPKSYIAAQGPLPHTLMDFWRMIWEQRVSVIVMVTNLEEKGRtKCHRYWPEEVGGQL
  ||.|||  ... ||. || |.||  .  |||||| |.|.. ..| ||  ..|  .|. .|||..... .| .|..|.  .  . ... |||..   | 
kenreknrdvkvvPyDynRvvLekldGeeksdYinavyvdsflkkkeyivteapkketvdefWrlvydeeisavvvLtktfdfak.mypsywpnkskeqy

pltTNMSVFMTKQEEFPDMVIRHLTV------------QVSQQSRVVTQFHYISWPD-HGVPDSTAGILTTIRRAKETRNQA----AAGPMVVHCSAGVG
    .. | ...........|| . .            ||. . |.|..|..  |.  . || ||....  .||..  |...      ||.||..| |..
...geifveiveekqyanlkirtfkltkkivalteqekqvkaetRivklfqlteWeledkvPlstnalielrrrvrlwrekvdedpeegPvvvvssdGas

RTGTLIAIDYNLDKAASENKVDVMGSLNEMRRQRTTMVQTEGQYIFIYRALA
|.|  .||| ||...  |..||| . .  .||.|  .|..  .| .||  | 
RsGvylaidanlelvekeeevdvFeavktlrrsRpqLvenveeYkyiYdvll
subfamily_CG7180_pd Subfamily CG7180 1586-1851 6.9e-56 184.0 In-house 36-290 (296) alignment 
Range on Protein: 1586-1851
Range on HMM: 36-290/296.0
AAQQMANKSKNRFQNIMPYDASRVKLSALPGVVGSDYINASYIDGFRQRKQFIATQGPMQSTLADFWRMVWEQEVHSIVMLTHLEESGRqKSEQYWPSLG
.. .  |. |||  ...|||  || |. | |   ||||||.|.|.| . |..| |..|...|. .|||.|...|....|.||.  .  . .  .|||  .
gglrkenreknrdvkvvPyDynRvvLekldGeeksdYinavyvdsflkkkeyivteapkketvdefWrlvydeeisavvvLtktfdfak.mypsywpnks

sdPLNVGDLQVSISEEEHKSFGVERTLTLL----------NPVSDQAREVKHWQFPNWPSSGEMGSG-RDLVDLVMRVEDYARsKVvvpqeesiygnrea
    . |.. | | ||.. .  . ||. |           ..|. . | ||. |.  |..  .. .    |..|. ||. . . ||              
..keqygeifveiveekqyanlkirtfkltkkivalteqekqvkaetRivklfqlteWeledkvPlstnalielrrrvrlwre.kv..............

iNEHailQQLKPTVVHCSAGVGRTGAYCAAVICLERMKQENKVDLYQVTKHLRTQRPGMVQTAEQYAFVYRVILDYL
 .|.   .. .|.||..| |..|.|.|.|. ..|| ...|..||...  | || .||..|.. |.| ..| |.|...
.ded...peegPvvvvssdGasRsGvylaidanlelvekeeevdvFeavktlrrsRpqLvenveeYkyiYdvlleav
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 1565-1852 5.7e-54 177.8 In-house 11-278 (287) alignment 
Range on Protein: 1565-1852
Range on HMM: 11-278/287.0
QLDQEFRGLSQGPPSSNTRTDAAQQMANKSKNRFQNIMPYDASRVKLSALPgVVGSDYINASYIDGFRQRKQFIATQGPMQSTLADFWRMVWEQEVHSIV
..|.|.  | .   ||     ||...|. .|||. ...|.| .|| ||| .   ||||||| |. .... ..|||.|||. .|. ||||.|.|... |..
dvdkevdalkedsesstatfkaaeelaavkknryadvlPiddtrvllsaeg.elGsdyinanyvasytddeafiaaqgPiaatvrdfwravletrsasvi

MLTHLEESGRQKSEQYWPSLgSDPLNVGDLQVSISEEEHKS--FGVeRTLTLLNPVSDQAREVKHWQFPNWPSSGEMGSGRDLVDLVMRVEDYarskvvv
..|.  | .|.|  .|||     |. ||   | . . . |.  .|| |.| |..  . .|| ||  .. .||. .   .   |. .|. |...       
tmtreveearlkcykywPer.evPmrvGGysvvlldydikePeygv.ralrlidletrearvvkqldllswPdkvlaPtavglirfvldvkqh.......

pqeesIYGNREAinehailQQLKPTVVHCSAGVGRTGAYCAAVICLERMKQENKVDLYQVTKHLRTQRPGMVQTAEQYAFVYRVILDYLD
     |  .|.|       ..  | |||...|.||.| . | .....|...  .||  .|  .|| .| ..||.. |. ..|  .  |  
.....ielarda.......sevGPlvvhddvGiGrsGillatlvlvsrledlGrvdvaavvirlreyraalvqavvqlrllyealvtyyk
0041856 (Phosphotyrosine protein) phosphatases II 1301-1534 1.1e-53 176.8 In-house 1-169 (182) alignment 
Range on Protein: 1301-1534
Range on HMM: 1-169/182.0
NRQKNRFANILAYDHSRvplhklpndpYSDYINANYIDGYNQPKSYIAAQGPLPHTLMDFWRMIWEQRVSVIVMVTnleekgrtkCHRYWPEEVggqlpl
|. |||. .|| |||||          ..||||||...|.  .. .||.||||..|. ||.||..|.....||..|         ...||||..      
nldknrysdilpydhsr..........dldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt.........eelywpell......

ttnmsvfmtkqeefpdmvirhltvqvsqqSRVVTQFHYISWPDHGVPDsTAGILTTIRRAKEtrnqaAAGPMVVHCSAGVGRTGTLIAIDYNLDKaasen
                              | ..|..|..|||||||| .  .|  |....|       || .|||||||||||||.|... . .     
.............................erlgiqylylpwpDhgvpd.ldelldfieevle.....eggpvlVHCsaGvgRtgtlvaaylmkkl.....

KVDVMGSLNEMRRQRTTMVQTEGQYIFIYRALAD
.|..   ....|..|  ||.|. ||.|...|| .
gvsleeavklvrsrRpgmvitpnqyfflqlalle
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 1291-1532 4.9e-53 174.8 In-house 23-262 (283) alignment 
Range on Protein: 1291-1532
Range on HMM: 23-262/283.0
FGRNYAIMDRNRQKNRFANILAYDHSRVPLHKLPNdpysDYINANYID---GYNQPKSYIAAQGPLPHTLMDFWRMIWEQRVSVIVMVTNLEEKGRTKCH
   . |  |.|..|||. .|...|  || |. ...    ||||| .|     |.| | ||.||.|| .| .|||.|....... |||.|.| |  | || 
ldadiasadenkrknrnqeivpadqwrvelksesr....dyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfdekitaivmltklqedlrikCs

RYWPEEVGGQLpltTNMSVFMTKQEEFPDMVIRHLTVQVS---QQSRVVTQFHYISWPDHGvPDSTAGILTTIRRAKETRNQAAAGPMVVHCSAGVGRTG
.|||..   .     .. | . |.     ..|. |...|.   ... ... . .| | . | ...    |  . . .  ...   ||.|||||.|.|||.
qyWPkrGsedy...GeftvtlrkettsnsfiikelllrvnssakstlllahyqvidWleyg.eqaiinslvkfnkvislqteskkgPivvhCstgiGrta

TLIAIDYNLDKAASENKVDVMGSLNEMRRQRTTMVQTEGQYIFIYRAL
..||.   ...| .|  |||.  .. || || ..||| .|| ... . 
vfiaasasvkdaltesvvdvfavvkimreqrmmavqtldqyklvhelv
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 1541-1757 5.1e-52 172.0 In-house 3-219 (298) alignment 
Range on Protein: 1541-1757
Range on HMM: 3-219/298.0
TEMSPETLRKHFDELRKPV-SSGGTQLDQEFRGLSQGPP-SSNTRTDAAQQMANKSKNRFQNIMPYDASRVKLSALPGVVGSDYINASYIDGFRQRKQFI
||.. |.|.... .| .   . . |....||. |...     .. ...|.. .||.|||...|...| ||| |..  .   |||||||.......|. ||
teieaedlkaalqklaavkkkkkltgyalefqrlnsvsseieeeekevarkpenkkkNRyadiialdssRvvLekedadeesdYiNAsflhaykgrnafi

ATQGPMQSTLADFWRMVWEQEVHSIVMLTHLEESGRQKSEQYWPSLGSDplNVGDLQVSISEEEHKSFGVERTLTLLNPVSDQAREVKHWQFPNWPSSGE
|||.|...|..||||||.|... .||||| |||... | ..|||. |..  . |...||. ..|...  . |.|.. .  ... |||.. .| .||. |.
atqaPltetvedFWrmvteedigtiVmltnleeldktkyhkywPdegke..tygeitvsllskeefadlivrklkvskkkeekerevrqlhftsWpdkgv

MGSGRDLVDLVMRVEDYAR
    . ..||. .|. . .
penatsvldllrkvrasqq
subfamily_PTPN1_pd Subfamily PTPN1 1580-1849 1.6e-50 166.5 In-house 20-269 (290) alignment 
Range on Protein: 1580-1849
Range on HMM: 20-269/290.0
SNTRTDAAQQMANKSKNRFQNIMPYDASRVKLSALPGvvgsDYINASYIDGFRQRKQFIATQGPMQSTLADFWRMVWEQEVHSIVMLTHLEESGRQKSEQ
|. .| .|.. .|...||.... ||| ||.||         |||||| ..  . ....| ||||. .| . ||.|||||. ...||| .. | ...|  |
sdfptreaklpenrnlnryrdvspydhsrikleradn....dyinaslveleeakrsyiltqGPlpntvdhfWqmvWeqkskavvmlnkvvekeqikcaq

YWPSLGS-DPLNVG--DLQVSISEEEHKSFGVERTLTLLNPVSDQAREVKHWQFPNWPSSGEMGSGRDLVDLVMRVEDyarSkvvvpqeesiyGnreain
|||.  . . | .    |.| . .||.||. . |.| | |  ....||. |. .  ||  |   |   .......| .   |           |      
ywPqgeeekellledtklkvkliseerksyytvrllelenlktqetreilhfhyttwpdfgvpespaaflkflfkvre...s...........G......

ehAILQQLKPTVVHCSAGVGRTGAYCAAVICLERMKQENK---VDLYQVTKHLRTQRPGMVQTAEQYAFVYRVILD
  .. ..  |.|.|||||.||.|..| .  || .......   ||. .|  .|| .| |..|||.|  | |  ||.
..slssdvGpavihcsaGiGrsGtfclvdtclvliekkddlssvdikkvllelrkyrlGliqtadqlrfsylaile
subfamily_PTPRA_pd Subfamily PTPRA 1550-1755 3.2e-50 165.9 In-house 18-223 (330) alignment 
Range on Protein: 1550-1755
Range on HMM: 18-223/330.0
KHFDELRKPVSSGGTQLDQEFRGLSQGPPssNTRTDAAQQMANKSKNRFQNIMPYDASRVKLSALPGVVGSDYINASYIDGFRQRKQFIATQGPMQSTLA
|  .|.|. ..    .. .||  |  ||   ..  ..|..  || |||. ||.||| ||| || . ||  |||||||.|||......|||.||| . |. 
kleeeirirsaddnklfreefnalPagpi..qatlelaskeenkeknrvvnilPydfsrvilsvkeGveesdyinasfidGykekdkfiaaqGPkeetve

DFWRMVWEQEVHSIVMLTHLEESGRQKSEQYWPSLGSdpLNVGDLQVSISEEEH-KSFGVERTLTLLN---PVSDQAREVKHWQFPNWPSSGEMGSGRDL
|||||.|||. ..|||||.|.|  ..| .||||. |.  .  |...|.. .|.  ... |   |          ...| |. . |  ||  |    .. .
dfwrmiweqksativmltelkerkeekcaqywPdeGl..vtyGnirvevedetvlvdytvrkflvqqlpdatrekksrlvrqfhftswPdvGvPfepiGm

VDLVMRVEDY
..|. .|.  
lkllkkvkkl
0036282 (Phosphotyrosine protein) phosphatases II 1329-1529 3.3e-50 165.5 In-house 2-163 (174) alignment 
Range on Protein: 1329-1529
Range on HMM: 2-163/174.0
SDYINANYIDGYNQPKSYIAAQGPLPhtlmdFWRMIWEQRVSVIVMVTNLEEKGRTKCHRYWPEevggqlplttnmsvfmtkqeefpdmvirhltvQVSQ
||||||...|..  .. .|| ||||.     ||.|..|......||.....|.|..||..||||                                  . 
sdyinaspldlsyitprliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe................................lred

QSRVVTQFHYISWPDHGVPDSTAgILTTIRRAKETRNQAAAGPMVVHCSAGVGRTGTLIAIDYNLDKAAsENKVDVMGSLNEMRRQRTTMVQTEGQYIFI
 .| . |..|. ||||||||..  .|. .....| ...   ||..|||||||||||||.|... |     |. ||..  . |.|.||  ||||..||.|.
lerlgiqylylpwpDhgvpdlsi.llefvkfveealsedpggpvlVHCsaGvgRtGtlvaaylmlrgll.eslvdaldlvrelRlqrpgmvqtpsQyrfl

Y
|
y
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 1295-1540 7.4e-50 164.7 In-house 35-281 (307) alignment 
Range on Protein: 1295-1540
Range on HMM: 35-281/307.0
YAIMDRNRQKNRFANILAYDHSRVPLhKLPnDPYSDYINANYIDGYNQPKSYIAAQGPLPHTLMDFWRMIWEQRVSVIVMVTNLEEKGRTKCHRYWPEEV
   .. | .|||. .. . |..|. . |..    |||| |||.    .|| .|.|||||  |  .|| |. ...|  ..|. .. | .. ||..||| | 
veafsantdknryqdvkcqdkgrivv.kfd.glasdyihanylgiaikpkkficaqgplentqysfwamaiqekvesvimlckvielakikceqywplee

GGQLPL-----TTNMSVFMTKQEEFPDMV--IRHLTVQVSQQSRVVTQFHYISWPDHGVPDSTAGILTTIRRAKETRNqaaagPMVVHCSAGVGRTGTLI
| .|       | ... . .|.    . .  .  | |. .|.|| .... .  |||.|||.   . .  .   .  .|     |.||||||||||.||..
gqklvfgeapntisvanlgakklapdedlinvttlkvdwaqksrtiqhlqwenwpdrgvpqinltainlleavrydtn.....pvvvhcsaGvGrsGtiv

AIDYNLDKA-ASENKVDVMGSLNEMRRQRTTMVQTEGQYIFIYRALADGLSNIV
|| .  ||  | .|  |.   ..|.| ||   .||| ||....| | . . .  
aislvqdkmiaGinckdmkklveelrsqrhyaiqteaqylylhrvlleyflely
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 1588-1850 5.9e-49 161.5 In-house 29-294 (297) alignment 
Range on Protein: 1588-1850
Range on HMM: 29-294/297.0
QQMANKSKNRFQNIMPYDASRVKLSAlpGVVGSDYINASYIDGFRQ--RKQFIATQGPMQSTLADFWRMVWEQEVHSIVMLTHLEESGRQKSEQYWPSLG
.. .   |||...|. .| .||||    .. ..||||| |.    .    ..| .|||...|. |||..|.||.|  |||...|.| ||.|   ||||  
krnsslrknryrdilatddtrvkllr..viterdyinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmvaklqedGrdkcapywpsvv

SDPLNVGDLQVSIS---EEEHKSFGVeRTLTLLNPvsDQAREVKHWQFPNWPSSGEMGsgrDLVDLVMRVEDYARSKVVVPQEESIYG--------NREA
 . |. ||. |       .|..   .   |.|.    .. | |.| || .||  |      || |||    . .   ..||   ..          . |.
qerlkagdvvveflsstsdefdrvil.telqliyr..sesrvvrhvqflswpdhGvps...dledlvrfqaqvcscciavpmmlalvemftamvflqles

IneHAILQQLKPTVVHCSAGVGRTGAYCAAVICLERMKQENKVDLYQVTKHLRTQRPGMVQTAEQYAFVYRVILDY
.  .|   .  ...|||||||||.|    . . |......   |   . ..|| ||. .||| ||. ..| ..|  
l..raemprnayllvhcsaGvGrsGvvvlsdvilaklrkkripdvaailsilreqrarlvqtleqfellydavlkk
0043147 (Phosphotyrosine protein) phosphatases II 1326-1529 2.4e-48 159.4 In-house 2-154 (172) alignment 
Range on Protein: 1326-1529
Range on HMM: 2-154/172.0
DPYSDYINANYIDGYNQPKSYIAAQGPLPHTLMDFWRMIWEQRVSVIVMVTNLeekgrtkchrywpeevggqlplttnmsvfmtkqeefpdmvirhlTVQ
|..||||||.|.|.|  |...|| ||||..|| |||||..|. ...||..|.|                                            .. 
degsdyinasyldlyyipdrfiatqgplrntladfwrmlkelgithivnltel............................................lyd

VSQQSRVVTQFHYISWPDHGVPdSTAGILTTIRRAKETRNQAAAGPMVVHCSAGVGRTGTLIAIDYNLdkaaseNKVDVMGSLNEMRRQRTTMVQTEGQY
 .. .| . |..|..||||||| ... .| ...  .|  ..   ||..|||||||||||||.|... |       ....   ....|..|  .||...||
pellerlgiqylylpwpDhgvp.llellleflefidellalspggpvlVHCsaGvgRtgtlvaaylml......lglsleeavalvrekRpgavqnpsqy

IFIY
.|.|
rfly
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 1295-1534 2.9e-48 159.0 In-house 48-281 (290) alignment 
Range on Protein: 1295-1534
Range on HMM: 48-281/290.0
YAIMDRNR--QKNRFANILAYDHSRVPLHklpNDPYSDYINANYIDGYNQPksYIAAQGPLPHTLMDFWRMIWEQRVSVIVMVTNLEEKGRTKCHRYWPE
  |.|.|   .|||. ..   | .|| |.   .    ||. |||..| . .  .| .||.|  | .|.|||. ...|..|||. .| |.|..||..|.||
rkifdkntefkknrykdvvcndktrvilk...dGydGdyvhanyvkGlkam..filtqGalkdtvidiwrmvlqekvaaivmlceliedGkakceqyype

EVGGQLPLTtNMSVFMTKQEE-FPDMVIRHLTVQVS--QQSRVVTQFHYISWPDHGVPDSTAGILTTIRRAKEtrnqaAAGPMVVHCSAGVGRTGTLIAI
. |  | .  ...|  .....   ... . |.|.     .. ..  .. .||||. |. ||  .| |.|  ..     |.||.|||||||.|||||..||
keGevltfG.eitvlcseeddkdaniikktlsvrdkdsGkehklkhlkikswpdksvalstlallrtlrilrk.....asGpvvvhcsaGiGrtGtfvai

DYNLDKAASENKVDVMGSLNEMRRQRTTMVQTEGQYIFIYRALAD
.  |.      ..|...    .|. | . || . ||. . ..| |
evglqilldGkeldlldlvralrnsrlnsvqvdiqylalveilld
subfamily_ptpA1_pd Subfamily ptpA1 1299-1488 3.9e-48 159.2 In-house 45-248 (418) alignment 
Range on Protein: 1299-1488
Range on HMM: 45-248/418.0
DRNRQKNRFANILAYDHSRVPLHKLPNDPYSDYINANYIDGyNQPKSYIAAQGPLPHTLMDFWRMIWEQRVSVIVMVTNLEEKGRTKCHRYWPEEVGG-Q
 .|  |||..|||  .|.|| |.|. .   |||||||||||   || .|..||||| |. |||||.||.|. .|||..   |. | || |||||..|| |
khntsknrytnilpvnhtrvqlkkiqdkegsdyinanyidg.aypkqfictqgplpntiadfwrmvwenrcriivmlsresencrikcdrywpeqiggeq

LPLTTNM-SVFMTKQEEF--------PDMVIRHLTVQVSQQSRVVTQFHYISWPDHGVPDSTAGILTTIRRAKETRNQA-----AAGPMVVHCSAGVGRT
. .  |   || |   |.         ... | . . .  ..| .||..|  |||| .|| |  .   ..   . .||         |..||||||||||
fsiygngnevfgtysvelveviqdpereiitrnirltfegetrditqyqyegwpdhnipdhtqpfrqllhsitnrqnqiipssdrnvpiivhcsagvgrt

GTLIA
||. .
gtfct
0041856 (Phosphotyrosine protein) phosphatases II 1592-1851 2.1e-47 156.4 In-house 1-171 (182) alignment 
Range on Protein: 1592-1851
Range on HMM: 1-171/182.0
NKSKNRFQNIMPYDASRvklsalpgvvGSDYINASYIDGFRQRKQFIATQGPMQSTLADFWRMVWEQEVHSIVMLThleesgrqkSEQYWPslgsdplnv
|..|||...|.||| ||          ..|||||....| .  ..|||||||..||.|||.||..|. ...||.||         .|.|||         
nldknrysdilpydhsr..........dldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt.........eelywp.........

gdlqvsiseeehksfgvertltllnpvSDQAREVKHWQFPNWPSSGEMGsGRDLVDLVMRVEDyarskvvvpqeesiygnreainehailqQLKPTVVHC
                           ..  |.. .... .||  |     ..|.|.. .|..                            . .|..|||
...........................ellerlgiqylylpwpDhgvpd.ldelldfieevle............................eggpvlVHC

SAGVGRTGAYCAAVICLERmkqenKVDLYQVTKHLRTQRPGMVQTAEQYAFVYRVILDYL
||||||||...|| .....     .|.|... |..| .|||||.| .|| |.....|..|
saGvgRtgtlvaaylmkkl.....gvsleeavklvrsrRpgmvitpnqyfflqlallell
subfamily_PTPRN_pd Subfamily PTPRN 1564-1848 3.9e-47 155.4 In-house 29-289 (297) alignment 
Range on Protein: 1564-1848
Range on HMM: 29-289/297.0
TQLDQEFRGLSQGPPSSNTrTDAAQQMANKSKNRFQNIMPYDASRVKLSALPGVVGSDYINASYIDGFRQRK-QFIATQGPMQSTLADFWRMVWEQEVHS
..|..|. .| .     .| ...|..  | .||| ....||| |||||..      ||||||| |     |.  .||||||. ||.||||.||||| |  
drlekewealcayeaepst.kevakaeknvkknrskavlpydhsrvklkeeasaeksdyinasaildhdprapayiatqgplastvadfwqmvweqGvvv

IVMLTHLEESGRQKSEQYWPSLGSDPLNVGDLQVsISEEEHKSFGVERTLTLLNPVSDQAREVKHWQFPNWPSSGEMGSGRDLVDLvmrvedyaRSKVvv
||.||.|||.| .. ..|||  ||.  .. .... .||       . |.. | |  ....| |  . |  ||..|   | . |...        | ||  
ivnltrleeegvkqckrywpdeGsevyhiyevhl.vsehiwcddylvrsfylknlqtsetrtvtqfhflswpeegvPasaksllef........rrkv..

pqEESIYGnREAinehailqqlkPTVVHCSAGVGRTGAYCAAVICLERMKQE-NKVDLYQVTKHLRTQRPGMVQTAEQYAFVYRVIL
  . |  | | .           | |||||.|.||||.|..  . |.|...  ...|.    .||| ||||.|.| .|. |.. .. 
..nksyrG.rsc...........pivvhcsdGaGrtGvyilidlvlnrllkGvkeidiaatlehlrdqrpglvktkdqfefaltava
0046846 (Phosphotyrosine protein) phosphatases II 1320-1532 8e-47 154.5 In-house 3-169 (176) alignment 
Range on Protein: 1320-1532
Range on HMM: 3-169/176.0
LHKLPNDPYSDYINANYIDGYnqpkSYIAAQGPLPHTLMDFWRMIWEQRVSVIVMVTNLEEKGRTKCHRYWPEEVGGQLplttnmsvfmtkqeefpdmvi
|..|  |...||||||.|.|.     .|| |||||.||.||..|..|......|..|.. |.|| ||..||||. . ..                     
lrllgldldldyinanlilgs....rpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgi.....................

rhltvqvsqqsrvvtQFHYISWPDHGVPDStAGILTTIRRAKETRNQAaaGPMVVHCSAGVGRTGTLIAIDynldKAASENKVDVMGSLNEMRRQRT-TM
               |.... ||||||||. . .|. ..  .| ...   || .||||||.||||||.|..       .|. ..|   | ..|.||   .
...............qylhlpwpDhgvpdl.elllellefirealkeg..gpvlVHCsaGigRtgtlvaay....llelekglsveealalvreqRplga

VQTEGQYIFIYRAL
|||..|| |.|...
vqtpeQyrflyefe
0049772 (Phosphotyrosine protein) phosphatases II 1584-1854 1.1e-46 155.4 In-house 38-283 (314) alignment 
Range on Protein: 1584-1854
Range on HMM: 38-283/314.0
TDAAQQMANKSKNRFQNIMPYDaSRVKLSALPgVVGSDYINASYIDGFrqrKQFIATQGPMQSTLADF----------WRMV--WEQEVHSIVM------
. .|.. .|..|||...|.|.| .||.|. || | |||||||||.|||   ..|||||||.. |. ||          ||||  ... |. |||      
ilvadlflnrdknryldilpad.nrvilpglp.vsgsdyinasyvdgf...lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivmsrdevl

---------------LTHLEESGRQKSEQYWPSLGsdplnvgdlqvsiseeehksfgvertlT-------LlnpvsdqAREVKHWQFPNWPSSGEMgSGR
               |. | . | . ...... |                            .       .        |.. ..   ..|  ..  . .
adelsrLdaAlgKtpllildgngneptaadlellk...........................eelydpelf.......erlgikylripvpDgsap.lle

DLVDLVMRVEDYaRskvvvpqeesiygnreainehailqQLKPTVVHCSAGVGRTGAYCAAVICLERMkqenKVDLYQVTKHLRTQRP-----GMVQTAE
|. ...  .|.. .                         . .|..|||.||.|||| ...| ... ..    .|.| .. ...| .||     |.... |
dfdeflefieea.d.........................kggpvlvHCkaGkgRtgtfvvaaylmkll....gvsleealedvrlkRpinpnpgfieqle

QYAFVYRVILDYLDKQ
|| |.....|.||...
qyefilealleylkfl
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 1569-1851 1.3e-46 154.0 In-house 25-279 (439) alignment 
Range on Protein: 1569-1851
Range on HMM: 25-279/439.0
EFRGLSQGPPSSNTRTDAAQQMANKSKNRFQNIMPYDASRVKLSALPGVVGSDYINASYIDGFRQRKQFIATQGPMQSTLADFWRMVWEQEVHSIVMLTH
.|  ..   |  .  .  | |  ...|||.... ..| .|| |  .|||  | |||| ||.|. . | .|||||| . |  ||||.|.|. .  ||||| 
ifekinstspdyaciaslaaqeydqtknrykdvgafdhtrvtlqeipgvphshyinanyikGyyddklyiatqgpkkettddfwrlviekktvtivmltn

LEESGRqkseqYWPSlgSDPLNVGDLQVSISEEEHKSFGVERTLTLLNPV--SDQAREVKHWQFPNWPSsgemgsgRDLVDLVMRVEDYARskvvvpqee
| || .     ||||  ..    ||. | .  .      | | . ..|    ... | | ....  ||        ...      | |. |         
lvesyk.....ywps..daevcygdiavrvdrnielpnyvirgfkvfnerdttekertvlqfhyiawpd.......knvpaqashvldflr.........

siygnreAINEHAILQQLKPTVVHCSAGVGRTGAYCAAVICLERMKQENKVDLYQVTKHLRTQRPGMVQTAEQYAFVYRVILDYL
       |||     ..  | ||||||||||||.  |  |.||..| |||||.  . | || ||  |||.  || |.|  .|. .
.......ainsandkeeygpvvvhcsagvGrtGtiialdialeqlklenkvdikgivkvlrkqrkqmvqalcqyvfiynavledi
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 1561-1755 1.8e-46 153.9 In-house 31-217 (319) alignment 
Range on Protein: 1561-1755
Range on HMM: 31-217/319.0
SGGTQLDQEFRGLSQGPPSSNTRTDAaQQMANKSKNRFQNIMPYDASRVKLSALPGVVGSDYINASYIDGFRQRKQFIATQGPMQSTLADFWRMVWEQEV
   |.|  ||| ... ...  ..| |     || |||. ||...| ..|||  | |. .|||||||...|.......||.|||.. ||||||||.||...
ddltklevefrracklgvnladqtfa.nldqnkdknriinilafdknvvklerliGeefsdyinasfvtGyqrkdkyiaaqGPldntladfWrmiweync

HSIVMLThleesgRQKSEQYWPSLGSDPLNVGDLQVSISEEEHKsFGVeRTLTLLN-PVSDQAREVKHWQFPNWPSSGEMGSGRDLVDLVMRVEDY
 .||.||      ..|  ||||  .    . ....|.  || .. . | | . | .     . |... . |  ||  |   .. ||. || .|.  
stivllt......kdkcsqywplkivikeerfkvkvdsveetae.yvv.rdielsedgkekdirkitqfhflGwpdvGvpdypsdlmrlvkkvrhl
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 1580-1755 4.9e-45 149.0 In-house 34-210 (305) alignment 
Range on Protein: 1580-1755
Range on HMM: 34-210/305.0
SNTRTDAAQQMANKSKNRFQNIMPYDASRVKLSALPGVVGSDYINASYIDGFRQRKQFIATQGPMQSTLADFWRMVWEQEVHSIVMLTHLEESGRQKSEQ
 .. .|  .. |||.|||...|...| .|..|.. . .  ||||||||.||....|..|..|||...|.|||||...|  |..|||||.| | |..| .|
eeesidvgkkeankaknrlkeitlldddriiltekeslddsdyinasyvdgykrkkkyivaqgPlkntvadfWrliveekvstivmltklveggkdkCrq

YWPSLGSDPLNVGDLQVSISEEEHKSFGVERTLTLLN-PVSDQAREVKHWQFPNWPSSGEMGSGRDLVDLVMRVEDY
|||   ... . |...| ...|.. |  .|| |.. .   ... | | ..|. .||  |   .   |..|. ||.  
YWpesktekkefgefsvelksektasdyieRklkisiededkesrtvlqyqltdWPdhGvpqfatsllslikrvqkd
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 1569-1755 7e-45 148.7 In-house 3-181 (284) alignment 
Range on Protein: 1569-1755
Range on HMM: 3-181/284.0
EFRGLSQGPPSSNTRTDaAQQMANKSKNRFQNIMPYDASRVKLSALPGVVGSDYINASYIDGFRQRKQFIATQGPMQSTLADFWRMVWEQEVHSIVMLTh
||| ... ...  ..|  |    || |||. .|...| ..|||  | |. .|||||||.| |.......||||||.. ||||||||.||... .||.|| 
efrracklgvngtdqtf.anldqnkdknrighilafdknvvklerliGeefsdyinasfitGyqrkdkyiatqGPldntladfWrmiweyncstivllt.

leesgRQKSEQYWPSLGSDPLNVGDLQVSISEEEHKsFGVeRTLTLLN-PVSDQAREVKHWQFPNWPSSGEMGSGRDLVDLVMRVEDY
     ..|  ||||  .    . ....|.  || .. . | | . | .     . |... . |  ||  |   .. ||. || .|.  
.....kdkcsqywplkivikeerfkvkvdsveesee.yvv.rdielsedgkekdirkirqfhflgwpdvgvpdypsdlmrlvkkvrhl
0049772 (Phosphotyrosine protein) phosphatases II 1298-1541 7.3e-45 149.4 In-house 43-285 (314) alignment 
Range on Protein: 1298-1541
Range on HMM: 43-285/314.0
MDRNRQKNRFANILAYDhSRVPLHKLPNDPySDYINANYIDGYnqpKSYIAAQGPLPHTLMDF----------WRMI--WEQRVSVIVM-----------
  .|| |||. .|| .| .|| |..||..  ||||||.|.||.   ...||.||||..|. ||          |||.  ....| .|||           
lflnrdknryldilpad.nrvilpglpvsg.sdyinasyvdgf...lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivmsrdevladels

----------VTNLEEKGrtkchrywpeevggQL---------PlttnmsvfmtkqEEF-----PdmvirhltvqvsqqSRVVTQFHYISWPDHGVPdST
           ..| ..|               .                      ||      .              .| . ....| .||...| ..
rLdaAlgKtpllildgng..............neptaadlellk............eelydpelf..............erlgikylripvpDgsap.ll

AGILTTIRRAKETrnqAAAGPMVVHCSAGVGRTGTLIAIDYNLDKAasenKVDVMGSLNEMRRQRT-----TMVQTEGQYIFIYRALADGLSNIVT
. ..  ..  .|     . || .|||.||.|||||.....| . .     .|..   |...|..|.      ....  ||.||..|| . |... .
edfdeflefieea...dkggpvlvHCkaGkgRtgtfvvaaylmkll....gvsleealedvrlkRpinpnpgfieqleqyefilealleylkflkk
0051429 (Phosphotyrosine protein) phosphatases II 1620-1854 8.5e-45 148.8 In-house 4-228 (272) alignment 
Range on Protein: 1620-1854
Range on HMM: 4-228/272.0
SDYINASYIDGFRQ---RKQFIATQGPMQSTLADFWRMvWEQEVHSIVMLTHLEESGRQKSEQYWP----------SLGSDPLNVGDLQVSISEEEHKSF
|.||||....|. .   .. .....||.. | |||||. .|. ...||.|...|| ||.| ..|||          . .  . ..|.| | . .||....
sgyiNardvggygrvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseellld

GVERTLTLLNP-VSDQAREVKHWQFPNWPSSGEM-GSGRDLVDLVmrvedyarskvvvpqeesiygnreainehaiLQqLKPTVVHCSAGVGRTGAYCAA
 . |.|.| .    ..|||| |... .||  |    . ..|..|.                               |.  .| .||||||..||| ..|.
yilrellltlllsagearevmhlhytdwpdhgvpqeallellell...............................ld.ggpvlvHCsaGkdRTGtvval

VICLERMKQENKVD--------LYQVTKHLRTQRPGMVQTAEQYAFVYRVILDYLDKQ
...|...  |  ||        |... ..|| ||||.||| |||.|.|...|..|.. 
lllllgvsletivddYlltnlyleeaveelraqrpgavqteeqylflyeallellrsl
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 1592-1848 3.3e-44 145.9 In-house 3-236 (237) alignment 
Range on Protein: 1592-1848
Range on HMM: 3-236/237.0
NKSKNRFQNIMPYDASRVKLSALPGvvGSDYINASYIDGFRQ-RKQFIATQGPMQSTLADFWRMVWEQEVHSIVMLTHLEESGRQKSEQYWPSLgSDPLN
|| |||. ||. || ||| |    .  |||||||.|..||    |..||.|||..|.  |||.|||..    ||||| | |. ..|  .||||   .|  
nkiknrygnivaydhsrvvlkgags..gsdyinatylkgfdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywpst.dqpaa

VGDLQVSISEEEHKSFGVERTLTLLNPV-SDQAREVKHWQFPNWPSSGemgsgrdlV----DLVMRVedyaRskvvvpqeesiygnREAINEHAILQQLK
 | | ||.  .|. |    |.|.| . .   . | .. .||  ||  |        |      ..|     |              .. ||.   ...  
ygvltvslkkkeefsdytvrslllskrltlkevrlihqyqftswpdrg........vpqqtaallrf....r..............kniinrsphvsesg

PTVVHCSAGVGRTGAYCAAVICLERMKQENKVDLYQVTKHLRTQRPGMVQTAEQYAFVYRVIL
| ..|||||||||| .      | . |... ||.|.  . .  .|| ..|| .|| |....||
pwiihcsagvgrtgiflvidamlrqakekkvvdiynyvysieedrpyiiqtkdqyvfihqtil
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 1280-1532 3.4e-44 145.8 In-house 26-283 (305) alignment 
Range on Protein: 1280-1532
Range on HMM: 26-283/305.0
EEYECIESGSEFGRNYAIMD-RNRQKNRFANILAYDHSRVPLHklPNDPYsDYINANYIDGYNQPKSYIAAQGPLPHTLMDFWRMIWEQRVSVIVMVTNL
.|. ...   .| .  |. . ....|||. ..   |. || |.  .  |. .|| |||.    .|| .| .| || .|  ||| | ....|  | |. ||
aefvamkrfndfekmkafkeaqeagknrykdvgcldnnrvkle..gpwph.eyihanyvstptnpkrfictqaplektcadfwymclqdkveaifmlcnl

EEKGRTKCHRYWPEEVGGQLPLTTNMSVFMTKQEEFPDM--------VIR--HLTVQ-VSQQSRVVTQFHYISWPDHGVPDSTAGILTTIRRAKetrnqA
 |||  ||. |.. . . .| .  .    . | |    .        ...   |...   ...| ||..|.| ||| ||| .   ||  . .|.     .
lekgakkcleyfaskdkdvlefeekgqkisvkfessvtlkfrkdakakvtetvlviegpgekarkvthyhwidwpdrgvpaadlailellekar.....p

AAGPMVVHCSAGVGRTGTLIAIDYNLDKAASENKVDVM-GSLNEMRRQRTTMVQTEGQYIFIYRAL
. ||.|||||||.||||... ..| ||.  . ....     |. .| ||   .||. ||.|... .
skgpivvhcsagigrtgsvvmleyildqllagqiiedtdkilqkireqrnnsiqtdaqylfvhqvi
0049260 (Phosphotyrosine protein) phosphatases II 1336-1529 3.8e-44 145.3 In-house 1-143 (152) alignment 
Range on Protein: 1336-1529
Range on HMM: 1-143/152.0
YIDGYNQPKSYIAAQGPLPHTLMDFWRMIWEQRVSVIVMVTNLEEKGRTKCHRYWpeevggqlplttnmsvfmtkqeefpdmvirhltvqvsqqsrvvtQ
.||||..|. .||.|||.|.|| |||||..|. ...|||.|.|.|.|. ||..|.                                            |
fidgyampfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi............................................q

FHYISWPDHGVPDSTAGILTTIRRAKETrNQAAAGPMVVHCSAGVGRTGTLIAIDYNLdkaaseNKVDVMGSLNEMRRQRTTMVQTEGQYIFIY
.... ||||||||..  .|  ..  ..  ..   || .|||||||||||||.|... |      ..|..   .. .|..|  .|...||..|.|
ylhlpwpDhgvpdlsqlllflllfiekl.aldkggpvlVHCsaGvgRtgtlvaaylml......lgvsleeavalvrekRpgavpnpgqlrfly
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 1274-1535 1.1e-43 144.1 In-house 4-258 (267) alignment 
Range on Protein: 1274-1535
Range on HMM: 4-258/267.0
SDFAFSEEYECIESGSEFGRN--YAIMDRNRQKNRFANILAYDHSRVPLHKLPNDpysdYINANYIDGYNQPKSYIAAQGPLPHTLMDFWRMIWEQRVSV
..  . .|.| |.  |.   .    |   |...||. . | ||..||.| .  ..    |||| |..||.. . .|. |.||  |  ||. .| .|.|.|
eeceiekefelikkisdtsstisqsiaeknqernrlddnlpyddtrvilrtkeee....yinasyvegyktknafivtqdplkntitdfltvihdqkvpv

IVMVTNLeekGRTKCHRYWPEEVGgQLPLTTNMSVFMTKQEEFPDMVIRHLTVQVSQQS-RVVTQFHYISWPDHGVPDSTAGILTTIRrAKETRnQAAAG
||..|.    .  . ...|| ..| |     ...|  . ..|  |  |  | ... ..| . || ..|  |            |  |  ||.   . .  
ivlltkv...ftdnirlfwPPkmg.qakkyqdltvehslekeendyqiitlelkfknesahnvtlyyykkwnintnnkpylkplfgil.aknql.engnr

PMVVHCSAGVGRTGTLIAIDYNLDKAASENKVDVMGSLNEMRRQRTTMVQTEGQYIFIYRALADG
|.||.||.||||.||.. ||  |..|  |. .|.   | ..| || ..|.|  .||.|.. ||. 
PlvvacsdGvGrsGtflvidsqleraktegvsdifdflrkirsqriglvdtkeryiyihellaey
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 1299-1532 2.5e-43 142.8 In-house 53-285 (305) alignment 
Range on Protein: 1299-1532
Range on HMM: 53-285/305.0
DRNRQKNRFANILAYDHSRVPLHKLPndpYSDYINANYIDGYNQP-KSYIAAQGPLPHTLMDFWRMIWEQRVSVIVMVTNLEEKGRTKCHRYWPEEVGGQ
| .  |||.... . |.| | |.| .    |||| |||.     | | .|.||||| .|. .|| |. ...|  |||. .  | |. || .|||   | .
diaitknryqdvpcqdqsavkldkps...psdyihanyvgcpmipekrficaqgpldqtidefwwmviqnkveqivmlcktvelgklkcaqywpaaqgek

LPLTTNMSVF---MTKQ-EEFPDMVIRHLTVQV-SQQSRVVTQFHYISWPDHGVPDSTagiLTTIRRAKETRNqaAAGPMVVHCSAGVGRTGTLIAIDYN
| | . . |     .|  |  ... |  | .    .|.  | ....  ||| |||      ||..      |   .  |.|||||||.|||||..||.| 
lelksgivvenvsgskpmerdaeiqitllnltysgdqkmsvrhlqwtewpdrgvppck...ltslellsairg..skvpivvhcsagigrtgtivaieyi

LDKAASENKVDVMGSL-NEMRRQRTTMVQTEGQYIFIYRAL
|.| | ....  |  | . .| ||.  .|.. ||.||.| .
lekiaenkpcppmpelvkalrdqrafsiqndvqylfihrvm
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 1292-1448 2.7e-43 142.9 In-house 22-181 (297) alignment 
Range on Protein: 1292-1448
Range on HMM: 22-181/297.0
GRNYAIMDRNRQ--KNRFANILAYDHSRVPLHKLPndPYSDYINANYIDGYNQPK--SYIAAQGPLPHTLMDFWRMIWEQRVSVIVMVTNLEEKGRTKCH
| ...   ||    |||. .|||.| .|| | . .  . .|||||.|.   ....   || |||||  |. |||....|| | |||||..|.| || || 
gesfssakrnsslrknryrdilatddtrvkllrvi..terdyinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmvaklqedGrdkca

RYWPEEVGGQLPLTTNMSVFMTK-QEEFPDMVIRHLTVQVSQQSRVVTQFHYISWPDHGVPD
 |||. |...|  .  .  |...  .||  ...  |..   ..||||.   ..|||||||| 
pywpsvvqerlkagdvvveflsstsdefdrviltelqliyrsesrvvrhvqflswpdhGvps
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 1566-1752 3e-43 142.8 In-house 21-202 (315) alignment 
Range on Protein: 1566-1752
Range on HMM: 21-202/315.0
LDQEFRGLSqGPPSSNTRtdAAQQMANKSKNRFQNIMPYDASRVKLSALPGVVGSDYINASYIDGFRQRKQFIATQGPMQSTLADFWRMVWEQEVHSIVM
. .||. |  .|. ...|  .|..  | .|||..||.|.| .||||  .     ||||||||| .. . | .||.||| .... ||||||....| .|||
fseefhdlp.dPdiyrqr..varetinfkknryknilPldsarvkleviddsPdsdyinasyiksvdddkayiasqgPlkasvddfwrmvlqekvttivm

LTHLEESGRQKSEQYWPSLGSDPLNVGDLQVSISEEEHKSFGVERTLTLLNpvSDQAREVKHWQFPNWPSSGEMGSGRDLVDLVMRV
.|...|. . |  ||||   .|  . | ..|.. . |  . || | |.. .  |.. | |  .|| .||  |       |. |.  |
vtkkqegdkikcrqywPdrkadsvefGsikvellsleadtdgvarklvtrk..seesrtvtqfqftewPdkGvdkqtssllklikev
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 1586-1848 3.5e-43 142.5 In-house 2-238 (239) alignment 
Range on Protein: 1586-1848
Range on HMM: 2-238/239.0
AAQQMANKSKNRFQNIMPYDASRVKLSALPGVVGSDYINASYIDGFR-QRKQFIATQGPMQSTLADFWRMVWEQEVHSIVMLTHLEESGRQKSEQYWPSL
||..  ||.|||. ||. || ||| |  |     ||||||||.  .    | .||||| .. .  |||||.|..    ||||| | |  ..|  ||||  
aakkrvnkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpds

GSDPLNvgdLQVSISEEEHKSFGVERTLTLLNPVSDQAREVKHWQFPNWPSSGemgsgrdlvdlvmrVEDYARskvvvpqeeSIYGNREAINEHAiLQQL
 |   |   |.|.. . |  .  . ||. . .    . | | ...|  ||  |              | .||          .. | |  | . . |   
tskycn...lrvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkg..............vpqyat.........avlglrrkitkds.lpga

KPTVVHCSAGVGRTGAYCAAVICLERMKQENKVDLYQVTKHLRTQRPGMVQTAEQYAFVYRVIL
.| |.|||||||||||.      | . |... ||...  | .| .|| ||||.||| |..  .|
rpwvihcsagvgrtgaflvidamlrqakkqktvdifnyvkairedrphmvqtseqyvfihlavl
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 1581-1752 3.6e-43 142.4 In-house 33-201 (515) alignment 
Range on Protein: 1581-1752
Range on HMM: 33-201/515.0
NTRTdAAQQMANKSKNRFQNIMPYDASRVKLSALPGVVGSDYINASYIDGFRQRKQFIATQGPMQSTLADFWRMVWEQEVHSIVMLTHLEESGRQKSEQY
  .|  ||.  | .|||..||.||| .||||  .     |||.||||| .|   | .||.||| .... ||||.|....|  |.|.|.|.|. . |  .|
ypqt.vaqeeinfkknryknilPydsvrvklevindnPhsdyfnasyipsfdndkayiasqgPnkasvddfWrlvlqenvttiamvtklkegdkikcgky

WPSLGSDPLNVGDLQVSISEEEHKSFGVERTLTLLNpvSDQAREVKHWQFPNWPSSGEMGSGRDLVDLVMRV
||   .| .. | ..|..   |  . |. |.||.|   .|..| |  ..| .||  |     . |. |.  |
WPdkpgdsvkfGsikvelvsleactggikrkltvlk..gddsrtvtqfhfteWPdkGvpkhtssllklikev
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 1586-1848 5.7e-43 141.8 In-house 1-237 (239) alignment 
Range on Protein: 1586-1848
Range on HMM: 1-237/239.0
AAQQMANKSKNRFQNIMPYDASRVKLSALPGVVGSDYINASYIDGFR-QRKQFIATQGPMQSTLADFWRMVWEQEVHSIVMLTHLEESGRQKSEQYWPSL
||..  ||.|||. ||. || ||| |  |     ||||||||.  .    | .||||| .. .  |||||.|..    ||||| | |  ..|  ||||  
aakkrvnkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpds

GSDPLNvgdLQVSISEEEHKSFGVERTLTLLNPVSDQAREVKHWQFPNWPSSGemgsgrdlvdlvmrVEDYARskvvvpqeeSIYGNREAINEHAiLQQL
 |   |   |.|.. . |  .  . ||. . .    . | | ...|  ||  |              | .||          .. | |  | . . |   
tskycn...lrvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkg..............vpqyat.........avlglrrkitkds.lpga

KPTVVHCSAGVGRTGAYCAAVICLERMKQENKVDLYQVTKHLRTQRPGMVQTAEQYAFVYRVIL
.| |.|||||||||||.      | . |... ||...  | .| .|| ||||.||| |..  .|
rpwvihcsagvgrtgaflvidamlrqakkqktvdifnyvkairedrphmvqtseqyvfihlavl
subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 1301-1534 2.7e-42 139.4 In-house 37-267 (281) alignment 
Range on Protein: 1301-1534
Range on HMM: 37-267/281.0
NRQKNRFANILAYDHSRVPLHK-LPNDPYSDYINANYIDGYNQPKSYIAAQGPLPHTLMDFWRMIWEQRVSVIVMVTNLEEKGRTKCHRYWPEEVGGQLP
| .|||..|| . | ||| |.  .||   .||| ||||      . || .|||   |  |||||||..  . |||. .. |  | ||  |.| .    | 
nnkknrylnipcldisrvqlkvkmpnknstdyihanyirspflkrgyiltqgpkketradfwrmiwqenttaivmlcqfletnrekcaeyfprnahcclq

LtTNMSVFMTKQEEFPDMVIRHLTVQVSQQSRVVTQFHYISWPDHGVPDSTAGILTTIRRAKetrnqAAAGPMVVHCSAGVGRTGTLIAIDYNLDKAASE
.  ..||          .|  .| .    ..|..|.. .  |||  ||.|.  .|  .|. .     | . | |.||||||||.|||.|..  |.   | 
f.dklsvsyedstvnkslvttrlnlsyegetrlithwlwkewpdwqvpessevmlkilrkir.....arstppvihcsagvgrsgtlmaveialqsihsh

NKV-DVMGSLNEMRR-QRTTMVQTEGQYIFIYRALAD
  . |.   .  .|   |.. |||  ||..|.. | |
ftlpdikqivshlrvtgraasvqtlqqymliwkvlld
0036282 (Phosphotyrosine protein) phosphatases II 1619-1845 5.5e-42 138.8 In-house 1-164 (174) alignment 
Range on Protein: 1619-1845
Range on HMM: 1-164/174.0
GSDYINASYIDGFRQRKQFIATQGPMQstladFWRMVWEQEVHSIVMLTHLEESGRQKSEQYWPSlgsdplnvgdlqvsiseeehksfgvertltllnPV
||||||||..|...  . .||.|||..     ||.|..|. ....|||....| |. |  .|||.                                   
gsdyinaspldlsyitprliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe.................................lr

SDQAREVKHWQFPNWPSSGEMGSGRdLVDLVMRVEDYArskvvvpqeesiygnreainehailQ--QLKPTVVHCSAGVGRTGAYCAAVICLERMKqENK
.|  |.. .... .||  |.  .   | ..| .||..                          .  . .|..|||||||||||. .|| ..| ... |. 
edlerlgiqylylpwpDhgvpdlsi.llefvkfveeal.........................sedpggpvlVHCsaGvgRtGtlvaaylmlrgll.esl

VDLYQVTKHLRTQRPGMVQTAEQYAFVYR
|| ... . ||.|||||||| .|| |.| 
vdaldlvrelRlqrpgmvqtpsQyrflyy
0044763 (Phosphotyrosine protein) phosphatases II 1313-1530 7.6e-41 135.0 In-house 2-165 (178) alignment 
Range on Protein: 1313-1530
Range on HMM: 2-165/178.0
YDHSRVPLHKLPNDPYSDYINANYIDGYnqpkSYIAAQGPlphtlMDFWRMIWEQRVSVIVMVTNLEEKGRTKCHRYWPEEVGgqlplttnmsvfmtkqe
.|..|| |..|.. ..||||||..|...     |.....|      |......|. ...||..|.  | |. ||..||||| |                 
ldrtrvllsnleglersdyinaseilpg....lylgslpp.....addlellkelgithivnlteelelgflkcdpywpeeag.................

efpdmvirhltvqvsqqsrvvTQFHYISWPDHGVPDSTAGILTTIRRAKETRNqAAAGPMVVHCSAGVGRTGTLIAIDYNLDKaasenKVDVMGSLNEMR
                      |...| .|||||||... .| ...  .| ..    || .|||||||||.|||.|... .       ....   ....|
.....................iqylhipipDhgvpdllehflefvefieeald.ekggpvlVHCsaGvgRsgtlvaaylmkkl.....glsleeaielvr

RQRTtMVQTEGQYIFIYR
..|  .|...||. ..|.
erRp.ivpnpgqlrqLye
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 1577-1755 8.4e-41 135.0 In-house 35-211 (297) alignment 
Range on Protein: 1577-1755
Range on HMM: 35-211/297.0
PPSSNTRTDA-AQQMANKSKNRFQNIMPYDASRVKLSALPGVVGSDYINASYIDGFRQrkQFIATQGPMQSTLADFWRMVWEQEVHSIVMLTHLEESGRq
.|..|....  |..  | .|.|..||.||| |||||  .     |||.|||.. |...  ..|.|| ||..|.||||.||....|  ||||....|. . 
lpeaniqpqtvaekkvnfeksRYkniLPydssRvkLaivnddpdsDyvnasfvkgnkh..rlittqmPmkatvadfWamvldeqvstivmlnddnerdk.

KSEQYWPSLGSDPlnVGDLQVSISEEEHKSFGVERTLTLLNPVSDQAREVKHWQFPNWPSSGEMG--SGRDLVDLVMRVEDY
|  .||.  |. .   ||. | ..  .... ...|.|.. .  . . | || .|| .||.  .    | . |..|.  |.. 
kcaryWsdkgvtt..fGdvsvvllsvsereGfikrelevtkgkakarrvvkqyqfveWPdkaverkdsassllklisevrkd
subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 1290-1531 1.7e-40 133.5 In-house 41-285 (310) alignment 
Range on Protein: 1290-1531
Range on HMM: 41-285/310.0
EFGRNYAIMDRNRQKNRFANILAYDHSRVPLhKLPNDPYSDYINANYIDGYNQPKSYIAAQGPLPHTLMDFWRMIWEQRVSVIVMVTNLEEKGRTKCHRY
.    |  . .. .|||.....  | ||| | |. .  | ||| |||.      ...| .|||| ||..||||||...|   |... .  |.|| ||  |
dssltyeaykkymhknrysdvvcldtsrvkl.kidksryedyihanyvktnylrstficsqgplqhtiidfwrmifqeraesilllckvgeegrpkcvgy

WPE----EVGGQLPlTTNMSVFMtKQEEFPDMVIRHL--TVQVSQQSR-----VVTQFHYISWPDHGVPDSTAGilTTIRRakeTRNQAAAGPMVVHCSA
||     |  | .   ||.|    .. |  .. .  .   | | .|        |.  ..  ||| ||||      |  .|      |   || ||||||
wpslgvtetygcir.vtnlsess.eefeicnlavtfvpdnvpvdeqpanlkelrvslikwpnwpdrgvpdekch..tvpqr...llaqvrhgpcvvhcsa

GVGRTGTLIAIDYNLDKAASENKVDVMGSLNEMRRQRTTMVQTEGQYIFIYRA
|..|.....|.....||.   .|||.     |....|.  .||| ||..| | 
gkdrlyvvvalklkidkldrglkvdaeevktellksraiciqtelqyliidrv
subfamily_PTPN13_pd Subfamily PTPN13 1567-1759 4.9e-40 132.5 In-house 14-202 (273) alignment 
Range on Protein: 1567-1759
Range on HMM: 14-202/273.0
DQEFRGLSQGPPSSNtrTDAAQQMANKSKNRFQNIMPYDASRVKLSALPGvvgsdYINASYIDGF--RQRKQFIATQGPMQSTLADFWRMVWEQEVHSIV
..||. | .  |  .  .. ... .||.|||..|..|||..||||..  |     |||||.|      .. ..||.|||.  | .|||.|||||... |.
aeefkelrelkpldt..cevgkkkenkdknryrnvlPydetrvklgdegg.....yinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweqkaevia

MLTHLEESGRQKSEQYWPSLGSDPLNVGD-LQVSISEEEHKSFGVERTLTLLNPVSDQAREVKHWQFPNWPSSGEMGSGRDLVDLVMRVEDYARSK
|.|.  |.|. | ..|||.  ...| | . |.|.  . ....  | |.|.. .  | ..||| | .| .||  |   |  .|. .|..|   ....
mvtlekekgkvkchrywPesknkklkvsnrlevellkvqkldgfvvralavkdsesgesrevahlnfvkwPdhgvPssaaellqfvaevrrlqtda
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 1300-1535 8.9e-40 131.5 In-house 42-270 (288) alignment 
Range on Protein: 1300-1535
Range on HMM: 42-270/288.0
RNRQKNRFANILAYDHSRVPLHklpNDPySDYINANYIDGYNQPKSYIAAQGPLPHTLMDFWRMIWEQRVSVIVMVTNLEEKGRTKCHRYWPEEVGGQLP
 |  ..|. |.   | .|| |.   .||   ||.|| .   . ..  | || ||  |.  .|.|. |. |  |||...| |||. |   |.| ..| .  
anptrdryenlprcditrvkls...ddp.dfyiaanvvssakykrrlicaqaPlngtieelWkmllesdveyivmlcellekGkeksaeyfPsklGekar

LTTNMSVFMTKQEEFpDMVIRHLTVQVS---QQSRVVTQFHYISWPDHGVPDSTAGILTTIRRAketrnQAAAGPMVVHCSAGVGRTGTLIAIDYNLDKA
.  . .|   |...  | ...  ....|   ... .| . |.  |.|.|||..    |  . .      ..   |.|||.||||||||||| |   |. .
igrlctvvkkkradi.dklvkvsllriskegeekvivkilhlleWdddgvPenylsplrllevl.....kslqkPivvhssaGvGrtgtlililialesl

ASENKVDVMGSLNEMRRQRTTMVQTEGQYIFIYRALADG
 ... . .   |...| .|   .||| ||....| . . 
rlddflgirsllaklreerfkaiqtemqylyvhrcvlee
subfamily_ptpA1_pd Subfamily ptpA1 1566-1812 5.8e-39 129.0 In-house 23-257 (418) alignment 
Range on Protein: 1566-1812
Range on HMM: 23-257/418.0
LDQEFRGLSQGPPSSNTrtDAAQQMANKSKNRFQNIMPYDASRVKLSALPGVVGSDYINASYIDGFrQRKQFIATQGPMQSTLADFWRMVWEQEVHSIVM
. .||| | .    |.|     ..  | ||||. ||.| . .||.|  .    ||||||| ||||    ||||.||||.  |.|||||||||. .. |||
ikeefrlleesvgpset..segdkkhntsknrytnilpvnhtrvqlkkiqdkegsdyinanyidga.ypkqfictqgplpntiadfwrmvwenrcriivm

LTHLEESGRQKSEQYWPSlgsdplNVGDLQVSISEEEHKSFGVErTLTLLNPVSDQAREVKHWQFpnwPSSgEMGSGRDLVDLVMR-VEDYARSKVVVPQ
|..  |  | | ..|||       ..|  |.||  .  . ||   .. |.. . |  ||.   .      .   |  ||. .       |.       | 
lsresencrikcdrywpe......qiggeqfsiygngnevfgty.svelveviqdpereiitrni...rlt.fegetrditqyqyegwpdhnipdhtqpf

EESIYGNREAINEHA-ILQQLKPTVVHCSAGVGRTGAYCAAVICLERMK
 . ..   .  |.     ..  | .|||||||||||..|.||| .... 
rqllhsitnrqnqiipssdrnvpiivhcsagvgrtgtfctavimmkkld
0043147 (Phosphotyrosine protein) phosphatases II 1619-1844 9.7e-39 128.2 In-house 4-154 (172) alignment 
Range on Protein: 1619-1844
Range on HMM: 4-154/172.0
GSDYINASYIDGFRQRKQFIATQGPMQSTLADFWRMVWEQEVHSIVMLTHLeesgrqkseqywpslgsdplnvgdlqvsiseeehksfgvertltlLNPV
|||||||||.|. .  ..|||||||...||||||||..|. .. ||.|| |                                             |.. 
gsdyinasyldlyyipdrfiatqgplrntladfwrmlkelgithivnltel.............................................lydp

SDQAREVKHWQFPNWPSSGEMgSGRDLVDLVMRVED-YARSKvvvpqeesiygnreainehailqqLKPTVVHCSAGVGRTGAYCAAVICLermkqeNKV
..  |.. .... .||  |   . . | ...  ... .|.|.                         .|..|||||||||||. .|| ..|       ..
ellerlgiqylylpwpDhgvp.llellleflefidellalsp........................ggpvlVHCsaGvgRtgtlvaaylml......lgl

DLYQVTKHLRTQRPGMVQTAEQYAFVY
.|... ...|..|||.||. .|| |.|
sleeavalvrekRpgavqnpsqyrfly
0046846 (Phosphotyrosine protein) phosphatases II 1618-1852 4.2e-38 126.2 In-house 10-174 (176) alignment 
Range on Protein: 1618-1852
Range on HMM: 10-174/176.0
VGSDYINASYIDGFRqrkqFIATQGPMQSTLADFWRMVWEQEVHSIVMLTHLEESGRQKSEQYWPSLGSDPLnvgdlqvsiseeehksfgvertltllnp
 ..|||||..|.| |    .||||||. .|||||..|..|. .. .|.|| . | || |  .||| | .  .                            
ldldyinanlilgsr....piatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgi............................

vsdqarevkHWQFPNWPSSGEMGSgRDLVDLVMRVEDYArskvvvpqeesiygnreainehailQ-QlKPTVVHCSAGVGRTGAYCAAVicleRMKQENK
         .... .||  |   . ..| .|.  ....                          .   .|..||||||.||||...||      .. |. 
.........qylhlpwpDhgvpdl.elllellefireal.........................keg.gpvlVHCsaGigRtgtlvaay....llelekg

VDLYQVTKHLRTQRP-GMVQTAEQYAFVYRVILDYLD
...... ...| ||| |.||| ||| |.|...| .|.
lsveealalvreqRplgavqtpeQyrflyefellllk
0051082 (Phosphotyrosine protein) phosphatases II 1327-1531 1.1e-36 121.1 In-house 1-148 (151) alignment 
Range on Protein: 1327-1531
Range on HMM: 1-148/151.0
PYSDYINANYIDGYnqpksYIAAQGPLPhtlmDFWRMIWEQRVSVIVMVTNLEEKGrtKCHRYWPEEVggqlplttnmsvfmtkqeefpdmvirhltvqv
|.|||||..|..|.     ... .|||.    ||.....|. ...||.....|| |  .|..|.||.                                 
plsdyinfsyvtgg.....lyrsggpla....dflellkelgiktivnlrseeerg..ycpeylpelg................................

sqqsRVVTQFHYISWPDHGVPDSTAGILTTIRRAKEtrnqAAAGPMVVHCSAGVGRTGTLIAIDYNLDKaasenkVDVMGSLNEMRRQRTTMVQTEGQYI
    . |.......|||.|.|.|.. .|  .. . .       ||..||||||.||||||.|..  | .      |..   |.|.|..|. .||.. |..
....ievlhipildwpdpglplsfdavleflellld....kkngpvlvHCsaGkgRTGtlvalylmllg......vsleealeeyrlkrpgvvqpnqqfl

FIYRA
|...|
fqlfa
PTPc_DSPc_SM00012 1433-1533 2.3e-35 116.3 In-house 2-104 (105) alignment 
Range on Protein: 1433-1533
Range on HMM: 2-104/105.0
VTQFHYISWPDHGVPDSTAGILTTIRRAKETRNQAA-AGPMVVHCSAGVGRTGTLIAIDYNLDKAASE-NKVDVMGSLNEMRRQRTTMVQTEGQYIFIYR
|...|| .|||||||...  ||...|  |. .|... ..|.|||||||||||||..|.|. |..  .| ..||.   ..|.|.|| .||||| ||.|.||
vkhyhytgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqylflyr

ALA
||.
all
0049260 (Phosphotyrosine protein) phosphatases II 1627-1844 4.7e-35 115.9 In-house 1-143 (152) alignment 
Range on Protein: 1627-1844
Range on HMM: 1-143/152.0
YIDGFRQRKQFIATQGPMQSTLADFWRMVWEQEVHSIVMLTHLEESGRQKSEQYWpslgsdplnvgdlqvsiseeehksfgvertltllnpvsdqarevk
.|||... ..|||||||.  ||||||||..|. .. ||||| |.| |. | |||.                                             
fidgyampfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi.............................................

HWQFPNWPSSGEMGSGRDLVDLVMRVEDYARS--KvvvpqeesiygnreainehailqqlkPTVVHCSAGVGRTGAYCAAVICLermkqeNKVDLYQVTK
.... .|| .|   .   | .|.  .| .|..  .                          |..|||||||||||...|| ..|      ..|.|... .
qylhlpwpDhgvpdlsqlllflllfieklaldkgg..........................pvlVHCsaGvgRtgtlvaaylml......lgvsleeava

HLRTQRPGMVQTAEQYAFVY
..|..|||.|.. .|. |.|
lvrekRpgavpnpgqlrfly
subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 1294-1533 1.8e-34 114.0 In-house 28-267 (285) alignment 
Range on Protein: 1294-1533
Range on HMM: 28-267/285.0
NYAIMDRNRQKNRFANILAYDHSRVPLHKLpnDpySDYINANYID--GYNQpKSYIAAQGPLPHTLMDFWRMIWEQRVSVIVMVTNLEEKGRTKCHRYWP
 |.  . | . ||.|.. . . .|| |..   |   ||| |...   | .|  .||..||||| || |||.||...... ..|.  | | |  ||  |.|
tytayeanpdlnryadvrcieetrvvlknh..d..rdyihaswmrmpgkdq.styittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekcalyyp

EEVGGQLPLTT-NMSVFMTKQEEFPDMVIRHLTVQVSQQSR----VVTQFHYISWPDHGVPDSTAGILTTIRRAKETRNQaaAGPMVVHCSAGVGRTGTL
|..|  . .   ....   |.|     ..  |||  ....      . . .   |||.  |. .  ..   .  |.   .    |..|||||||||| |.
eklgevvkfgkyeitlteckeeaiagtilnaltvintedasseplymnhvqvpwwpdqlapedarpmielykwvkkvnpk..ekpicvhcsagvgrtatf

IAIDYNLDKAASENKVDVMGSLNEMRRQRTTMVQTEGQYIFIYRALA
. |||   .   . .....  . |||  |   ||.  |..|.|  | 
vgidyatirimenpniemldivremramrfqavqshmqflflyvvlm
0051082 (Phosphotyrosine protein) phosphatases II 1620-1847 3.2e-33 109.8 In-house 3-149 (151) alignment 
Range on Protein: 1620-1847
Range on HMM: 3-149/151.0
SDYINASYIDGFrqrkqFIATQGPMQstlaDFWRMVWEQEVHSIVMLTHLEESGrqKSEQYWPSLGsdplnvgdlqvsiseeehksfgvertltllnpvs
|||||.||..|.     .....||..    ||.....|. . .||.|. .|| |  .  .|.|.||                                  
sdyinfsyvtgg.....lyrsggpla....dflellkelgiktivnlrseeerg..ycpeylpelg..................................

dqaREVKHWQFPNWPSSGemgsgrdlvdlvmrvedyarskvvvpqE----ESIYGNREAINEhailQQLKPTVVHCSAGVGRTGAYCAAVICLERmkqen
   .||.|.....||  |                                ...    |....    .. .|..||||||.||||. .|....|..     
...ievlhipildwpdpg...........................lplsfdavleflellld....kkngpvlvHCsaGkgRTGtlvalylmllg.....

kVDLYQVTKHLRTQRPGMVQTAEQYAFVYRVI
 |.|... ...| .|||.||. .|. |.....
.vsleealeeyrlkrpgvvqpnqqflfqlfal
subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 1332-1526 3.8e-33 109.5 In-house 78-271 (301) alignment 
Range on Protein: 1332-1526
Range on HMM: 78-271/301.0
INANYIDGYNQPKSYIAAQGPLPHTLMDFWRMIWEQRVSVIVMVTNLEEKGRTKCHRYWPEEVGGQLPLTTNMsVFMTKQEE-FPDMVI-RHLTVQVSQ-
| ||.|.   .|. .||.||||. |  ||| |.    |  |||...  ||  .||. | | ... .| .   . . ....|  . . .. |.| |. |  
ihanwiptsGhphrfiatqgPlkntsedfwamlvqydvekivmlgqkvekleekceeylpvkisekldigrfk.ikiknkelilnkkiskrtlevedstg

--QSRVVTQFHYISWPDHGVPDSTAGILTTIRRAKETRNqaaagPMVVHCSAGVGRTGTLIAIDYNLDKAASENKVDVMGSLNEMRRQRTTMVQTEGQYI
  ..| || . | .|.|.||| | | .   .  .|....     |.|||||||.||. ..|. .|   .  .......  .|...| .| . |||. |  
kfatrtvthyqysewtdrgvPkshaelfdlmelvkksek.....PivvhcsaGiGrsvafigteylareveadptieltealkhlrehrwngvqtnsqly
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 1568-1740 2.1e-31 103.7 In-house 24-149 (392) alignment 
Range on Protein: 1568-1740
Range on HMM: 24-149/392.0
QEFRGLSqGPPSSNtrTDAAQQMANKSKNRFQNIMPYDASRVKLSALPGVVGSDYINASYIDGFRQRKQFIATQGPMQSTLADFWRMVWEQEVHSIVMLT
.||. |  ||. ..  . .||.  |. |||..||.|||..||||  .  .  |||.|||||..| . | .||.|||  ..| ||||||....| .|.|.|
eefhdlp.gpdiyp..qtvaqkeinlkknryknilpydsarvkleviddipdsdylnasyipsfdnekayiasqgpnaaslddfwrmvfqenvttiamvt

HLEESGrqkseqywpslgsdplnvgdlqvsiseeehksfgvertltllnpVSDQAREVKHWQFPNWPSSGEMG
.|.|                                                |.|| |  ..| .|| ..   
klkegd............................................kgddartvaqfhftewPdkdvpk
0044763 (Phosphotyrosine protein) phosphatases II 1603-1849 4.7e-31 103.2 In-house 1-169 (178) alignment 
Range on Protein: 1603-1849
Range on HMM: 1-169/178.0
PYDASRVKLSALPGVVGSDYINASYIDGFrqrkQFIATQGPmqstlADFWRMVWEQEVHSIVMLTHLEESGRQKSEQYWPSLGSdplnvgdlqvsiseee
|.| .||.|| |.|. .|||||||.|...     ......|     ||......|. ...||.||.  | |..|. .|||.  .                
pldrtrvllsnleglersdyinaseilpg....lylgslpp.....addlellkelgithivnlteelelgflkcdpywpeeag................

hksfgvertltllnpvsdqaREVKHWQFPNWPSSGEMGSGRDLVDLVMRVEdyarskvvvpqeesiygnreainehaiLQQLKPTVVHCSAGVGRTGAYC
                     ...|. .| ..    .   ...|... ..                             .. .|..|||||||||.|. .
....................iqylhipipDhgvpdllehflefvefieeal...........................dekggpvlVHCsaGvgRsgtlv

AAVICLERmkqenKVDLYQVTKHLRTQRPgMVQTAEQYAFVYRVILD
|| .....     ...|... ...| .|| .|.. .|. ..|.. | 
aaylmkkl.....glsleeaielvrerRp.ivpnpgqlrqLyefelr
subfamily_CG42327_pd Subfamily CG42327 1300-1463 2.9e-30 100.0 In-house 27-193 (319) alignment 
Range on Protein: 1300-1463
Range on HMM: 27-193/319.0
RNRQKNRFANILAYDHSRVPLHKLPNDPYSDYINANYIDGYNQ-PKSYIAAQGPLPHTLMDFWRMIWEQRVSVIVMVTNLEEKGRTKCHRYWPEEVGGQ-
  ..|.|..|..   ..|| |.. ..|. . |..|.|. ||.. | |||||| .|  .  ||||..|||.  ||| .|.| |.|  .| .|.| . ... 
tskdksrvinvvPlPetrvvlqrigdddkdeyldasyvrGyddapnsyiaaqvsledsssdfwrtvweqqsrvivqltdlselGikvcaeylPtketldn

LPLTTNMSVFMTKQEEFPDMVIRHLTVQV--SQQSRVVTQFHYiSWPDHGVPDSTAGILTTIRRAKET
  |  .. | . ..|     .|  | ..    ..|| .| . |  |.. .|| . | ... . .....
tslyGdilvtlkgrevkdryaistlllkrvdkeesrelthywy.kwleaevPaeeaaliamllevrss
subfamily_egg_pd Subfamily egg 1289-1535 4.5e-30 99.4 In-house 28-269 (307) alignment 
Range on Protein: 1289-1535
Range on HMM: 28-269/307.0
SEFGRNYAIMDRNRQKNRFANILAYDHSRVPLhKLPNDPYS-DYINANYIDGYNQPKSYIAAQGPLPHTLMDFWRMIWEQRVSVIVMVTNLEEKgrTKCH
 |   . |. | |..| |   .   | ||| | .|..  |. |.| ||...|      .| || ||  |  |||||.....|  |||.|   |    .|.
deislttaasdnnlekarskrvhckdssrvkl.elrrGqylddfihanrvkGkpllnefilaqaplkntvddfwrmvfqeevqyivmltsrkes..erce

RYWPEEVGGQLPL---TTNMSVFMTKQEEFPDMVIRHLTVqVSQQsrvVTQFHYISWpDHGVpDSTAGILTTIRRAKETRNqaAAGPMVVHCSAGVGRTG
 |||      | .   . ..  .  ...  | . . .| . |  .     . .   |    | . .. . . .|  .  ||  .. |.||..  || ...
yywpkaesdslvtvpGslrienlkvdskadplfrvtklkl.vGgd...deerflehw.qgdv.nnssdvysplrvlrklrn..lskpvvvqdilGvskaa

TLIAIDYNLDKAA--SENKVDVMGSLNEMRRQRTTMVQTEGQYIFIYRALADG
||.||.  | .       |  |. .   .|..|   |..  .|.|.|| ..  
tlvaieiallsllrGpitkslvlravvflrlrrrlsvesvllylfvyrlvlff
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 1782-1854 5.2e-29 96.3 In-house 214-286 (319) alignment 
Range on Protein: 1782-1854
Range on HMM: 214-286/319.0
QQLKPTVVHCSAGVGRTGAYCAAVICLERMKQENKVDLYQVTKHLRTQRPGMVQTAEQYAFVYRVILDYLDKQ
.| .| ||||||||||||....  . |||.|.|. .|.... ..|||||. |||. ||| |.| ..|....  
tqsgPivvhCsaGvGRtGtfivldamlervkeegvlDvfstvsrlRtqRnimvqrpeqYkfiyealleaveag
subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 1302-1536 1.3e-28 94.6 In-house 44-276 (312) alignment 
Range on Protein: 1302-1536
Range on HMM: 44-276/312.0
RQKNRFANILAYDHSRVPLHKLPNdpysDYINANYIDGYNQPKSYIAAQGPLPHTLMDFWRMIWEQRVSVIVMVTNLEEKGRTKCHRYWPEEVGgQLPL-
.. ||. ||  .|  |  |    |     || ||..    .|. ....||||  |   ||..      . |.... . | |  || .|  . ||  . | 
kdlnrypniqcwdrgrftlagden....fyihanfvkictkperfvctqgplentcthfwqlalslgstsiillcgfvedgsekcakyisdivg.fvdle

--------TTNMSVFMTKQEEFPDMVIRHLtVQVSQQSRVVTQFHYISWPDHGVPDSTAGILTTIRRAKETRNqaaagPMVVHCSAGVGRTGTLIAIDYN
         |.. .    ..     |.. . |. . |   . .. . ||||||.|||    |  .   |  ..     |.. ||||||||||||. |.  
dhrvyteycteieiggkskdkithrvlkvv.vkatgqesklnhyqwaswpdhgmpdscdtalrllsavkkdkk.....pviahcsagvgrtgtlaliesm

LDKAASENKVDVMGSLNEMRRQRTTMVQTEGQYIFIYRALADGL
.       | .|  |.  .|..|.  |..  ||..  |.. . |
iaalrhprkqnvkdsfvllrkdrarsvrvfpqyvyalrcvlefl
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 1428-1575 3e-28 93.3 In-house 86-234 (440) alignment 
Range on Protein: 1428-1575
Range on HMM: 86-234/440.0
QQSRVVTQFHYISWPDHGVPDSTAGILTTIRRAKETRNQAAAGPMVVHCSAGVGRTGTLIAIDYNLDKAASENKVDVMGSLNEMRRQRTTMVQTEGQYIF
 .||.. |.|| .|||.|||  .. .|  |.  .|....|. ||..||||||.|||| .||.|  | .|   ...|..  .| || .|  ||||  || |
iesrtlkqyhyqgwpdkgvpkfagpvlkmiqdvnesqekagngpllvhcsagagrtgviiavdsilreakrsdqidifsfinsmrnnrpqmvqtpeqyaf

IYRALADGLSNIVTEMSPETLRKHFDELRKPVSS-GGTQLDQEFRGLSQ
.. |. .||    | .  . . .. .... |      . |.||| | |.
vheavlegllcgdtliledditerveqiqwpnphtdksplqqefegysk
subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 1566-1752 1.1e-27 91.5 In-house 13-196 (281) alignment 
Range on Protein: 1566-1752
Range on HMM: 13-196/281.0
LDQEFRGLSQGPPSSNtRTdAAQQMANKSKNRFQNIMPYDASRVKLSA-LPGVVGSDYINASYIDGFRQRKQFIATQGPMQSTLADFWRMVWEQEVHSIV
. |||  |   |||    | . .|  |. |||. ||   | |||.|   .|    .||| | ||     .. .| |||| . | ||||||.|...  .||
fkqefsnlpgdppsdl.ct.vfnqpvnnkknrylnipcldisrvqlkvkmpnknstdyihanyirspflkrgyiltqgpkketradfwrmiwqenttaiv

MLTHLEESGRQKSEQYWPSLGSDPLNVGDLQVSISEEEHKSFGVERTLTLlnPVSDQAREVKHWQFPNWPSSGEMGSGRDLVDLVMRV
|| .. |. |.|  .|.|      |..  | ||  .   .   |   | |      ..| . || . .||     .|   .. .. ..
mlcqfletnrekcaeyfprnahcclqfdklsvsyedstvnkslvttrlnl..syegetrlithwlwkewpdwqvpessevmlkilrki
PTPc_DSPc_SM00012 1725-1848 1.8e-27 91.0 In-house 2-104 (105) alignment 
Range on Protein: 1725-1848
Range on HMM: 2-104/105.0
VKHWQFPNWPSSGEMGSGRDLVDLVMRVEDYARSK-VvvpqeesiygnreainehailqqLKPTVVHCSAGVGRTGAYCAAVICLERMKQE-NKVDLYQV
||| ....||  |   .. ....|.  |..  . .                          ||.|||||||||||| ..|. |.|.....| ..||..|.
vkhyhytgwpdhgvPeesdsilellravkknknkses.......................skpvvVhCsaGvgRtgtfvaldillqqleketkevdifqi

TKHLRTQRPGMVQTAEQYAFVYRVIL
 |.||.|||||||| ||| |.||..|
vkelrkqRpgmvqteeqylflyrall
subfamily_CG42327_pd Subfamily CG42327 1582-1758 2.3e-27 90.5 In-house 19-196 (319) alignment 
Range on Protein: 1582-1758
Range on HMM: 19-196/319.0
TRTDaAQQMANKSKNRFQNIMPYDASRVKLSALPGVVGSDYINASYIDGFRQR-KQFIATQGPMQSTLADFWRMVWEQEVHSIVMLTHLEESGRQKSEQY
.|.| .  .. | |.|. |..|   .|| |   .    . |..|||. |...   ..||.| ..... .||||.||||    || || | | | ..  .|
arad.evPvtskdksrvinvvPlPetrvvlqrigdddkdeyldasyvrGyddapnsyiaaqvsledsssdfwrtvweqqsrvivqltdlselGikvcaey

WPSLGSDP--LNVGDLQVSISEEEHKSFGVERTLTLLNPVSDQAREVKHWQFpNWPSSGEMGSGRDLVDLVMRVEDYARS
.|.  . .     ||..|.. . | |   .  || | .   ...||. |. . .|. ..   . . |. ....|..  .|
lPtketldntslyGdilvtlkgrevkdryaistlllkrvdkeesrelthywy.kwleaevPaeeaaliamllevrsslks
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 1783-1852 2.9e-27 90.6 In-house 212-281 (318) alignment 
Range on Protein: 1783-1852
Range on HMM: 212-281/318.0
QLKPTVVHCSAGVGRTGAYCAAVICLERMKQENKVDLYQVTKHLRTQRPGMVQTAEQYAFVYRVILDYLD
. .|.|||||||||||| ..|  | |||.|.|. ||..|. |.||.||. |||| .|| |.| |.|..| 
gagpivvhCsaGvGrtGvfiavdillerikaealvDvfqtvkqlreqrnlmvqtedqyefiydvlleala
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 1782-1852 3.1e-27 90.5 In-house 214-284 (305) alignment 
Range on Protein: 1782-1852
Range on HMM: 214-284/305.0
QQLKPTVVHCSAGVGRTGAYCAAVICLERMKQENKVDLYQVTKHLRTQRPGMVQTAEQYAFVYRVILDYLD
.. .| .|||||||||||...|  | |||.|.|. ||...|.|.||..|..|||| .|| |.. .. ... 
dkgvpllVhCsagvgRtGvfiavdialerlkkEevvdvfevlkqlRskrmkmvqtldqYvflhdaldelit
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 1762-1854 5.5e-27 89.8 In-house 201-293 (298) alignment 
Range on Protein: 1762-1854
Range on HMM: 201-293/298.0
VPQEESIYGNREAINEHAILQQLKPTVVHCSAGVGRTGAYCAAVICLERMKQENKVDLYQVTKHLRTQRPGMVQTAEQYAFVYRVILDYLDKQ
  ...|. . .. .. .      || .|.|||||||.|...|    |||.|.|..||..|| | ||..|||.||| |||.|.| ..|..||  
penatsvldllrkvrasqqqagnkpvivqCsaGvgRsGtfiaidsvlervkkeqvvDvfqvvkvlRkkrpgavqteeqYvfiyeavlealdsf
0048076 (Phosphotyrosine protein) phosphatases II 1411-1532 8.4e-27 89.0 In-house 22-139 (145) alignment 
Range on Protein: 1411-1532
Range on HMM: 22-139/145.0
QEEFPDMVI---RHLTVQVSQQSRVVTQFHYISWPDHGVPDSTAGILTTIRRAKETRNQAaaGPMVVHCSAGVGRTGTLIAIDYNLDkaaseNKVDVMGS
 |.. |. |     ||   .  .| ..|..|..||||||||... .|. ..  .| ...   ||..|||||||||||||.|..  |      ..|..   
lellkdlgittvlnltselellerlgiqylylpwpDhgvpdllellleflefieealkeg..gpvlVHCsaGvgRtgtlvaaylmll.....lgvsleea

LNEMRRQRTTMVQTEGQYIFIYRAL
|...|.||  .|...||..|.|...
lelvrsqrpgavpnpgqlrflyefe
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 1559-1751 1.2e-26 88.5 In-house 11-204 (307) alignment 
Range on Protein: 1559-1751
Range on HMM: 11-204/307.0
VSSGGTQLDQEFRGLSQGPPSSNTrTDAAQqmANKSKNRFQNIMPYDASRVKLSaLPGVvGSDYINASYIDGFRQRKQFIATQGPMQSTLADFWRMVWEQ
.  | ..| .||| |..  | . | ..| .  ||  |||.|..   | .|. .  ..|.  |||| | |.    . |.||..|||...|  .|| |. ..
ldkgvqalvdefrvlakktpegvt.veafs..antdknryqdvkcqdkgrivvk.fdgl.asdyihanylgiaikpkkficaqgplentqysfwamaiqe

EVHSIVMLTHLEESGRQKSEQYWPSLGSDPLNVGDLQV--SISEEEHKSFGVERT---L-TLLNPVSDQAREVKHWQFPNWPSSGEMGSGRDLVDLVMR
.| |..|| .. | .. | |||||    . |  |.     |...   | .  .     . ||    ....| ..|.|. |||  |        ..|.  
kvesvimlckvielakikceqywpleegqklvfgeapntisvanlgakklapdedlinvttlkvdwaqksrtiqhlqwenwpdrgvpqinltainllea
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 1592-1736 2.9e-26 86.8 In-house 56-196 (290) alignment 
Range on Protein: 1592-1736
Range on HMM: 56-196/290.0
NKSKNRFQNIMPYDASRVKLSAlpGVVGsDYINASYIDGFRqrKQFIATQGPMQSTLADFWRMVWEQEVHSIVMLTHLEESGRQKSEQYWPSLGSDPLNV
.  |||.....  | .|| |.   |  | ||. | |..| .    || |||....|  |.|||| ...|  ||||  | | |. | |||.|    . |  
efkknrykdvvcndktrvilkd..GydG.dyvhanyvkGlk..amfiltqGalkdtvidiwrmvlqekvaaivmlceliedGkakceqyypekeGevltf

GDLQVSISEEEHKSF-GVERTLTLLNPVSDQAREVKHWQFPNWPSS
|.. |  |||..|    . .||.. .  | .   .||..   ||  
GeitvlcseeddkdaniikktlsvrdkdsGkehklkhlkikswpdk
subfamily_PTPRA_pd Subfamily PTPRA 1783-1851 1.1e-25 85.3 In-house 227-295 (330) alignment 
Range on Protein: 1783-1851
Range on HMM: 227-295/330.0
QLKPTVVHCSAGVGRTGAYCAAVICLERMKQENKVDLYQVTKHLRTQRPGMVQTAEQYAFVYRVILDYL
.  | ||||||||||||....    |||.| |.|||.... |.||.||| |||| ||| |.|.|.|.| 
sagpivvhcsaGvGrtGtfivldavlervkaerkvdvfefvkrlrlqrpqmvqtdeqyefiykvlleyy
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 1588-1689 2.3e-25 84.1 In-house 43-158 (350) alignment 
Range on Protein: 1588-1689
Range on HMM: 43-158/350.0
QQMANKSKNRFQNIMPYDASRVKLS--------ALPGVVGSDYINASYIDGF----RQRKQF--IATQGPMQSTLADFWRMVWEQEVHSIVMLTHLEESG
. .   .|||..||.||. |||||             . ..|||||.|.       ..  .|  ||||.|..||. ||.... . .|. |..|| . | .
eGvelfaknrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvkvilsltsdveln

RQKSEQYWPSLGSDPL
..| ..||. .. |  
lekcyrYWqegsyddi
subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 1350-1536 2.8e-25 83.4 In-house 97-288 (302) alignment 
Range on Protein: 1350-1536
Range on HMM: 97-288/302.0
QGPLPHTLMDFWRMIWEQRVSVIVMVTNLEEKGRTKCHRYWPEEVGGQLPLTT---NMSVFMTKQEEFPDMV---IRHLTV----QVSQQSRVVTQFHYI
  |   ||  .| .| . .|...| .... |..  ||  |. ..|||.| .     .     |. ||| |     .  . .    . ... . |  ... 
ivpkkstlekhwalieqynvaivvqlcsfvedeekkcaeyysdkvggelkfgrytvktvsvktdleeftdkksfklytveiknekkkkkvkktvdilafs

SWPDHGVPDSTAGILTTIRRAKETRNQaaagpMVVHCSAGVGRTGTLIAIDYNLDKAASENKVDVMGSLNEMRRQRTTMVQTEGQYIFIYRALADGL
.||||| |. .   |  ..  .  ...     ..|||||||||||||.|| | ..  . ..  |..  .  .|. |   ||.| | |..   .. ||
awpdhGapkeaytaldilkfcesykkn.....vlvhcsaGvGrtGtlvaikyGiqlcskkkvtdllsivlpvrqcryGavqdeqqliylllcvtkgl
0048179 (Phosphotyrosine protein) phosphatases II 1429-1530 3.5e-25 83.8 In-house 45-139 (144) alignment 
Range on Protein: 1429-1530
Range on HMM: 45-139/144.0
QSRVVTQFHYISWPDHGVPDSTAGILTTIRRAKETRNQAaaGPMVVHCSAGVGRTGTLIAIDYNLdkaasENKVDVMGSLNEMRRQRTTMVQTEGQYIFI
  | ..|.....||||||||... .|....  .| ...   ||..|||||||||||||.|..  .     ......   |...|..|  .|...||..|.
leregiqylhlpwpDhgvpdllellleflefieealeeg..gpvlVHCsaGvgRtgtlvaaylmk.....klglsleealalvrsrrpgavpnpgqlrfL

YR
..
le
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 1303-1393 3.9e-25 83.3 In-house 49-153 (350) alignment 
Range on Protein: 1303-1393
Range on HMM: 49-153/350.0
QKNRFANILAYDHSRVPLHKLPNDP--------YSDYINANYIDGY----NQPKS--YIAAQGPLPHTLMDFWRMIWEQRVSVIVMVTNLEEKGRTKCHR
 |||. ||| |.|||| |.| .. .         .|||||||.       ..  .  |||.|.||| |. ||...| .  | ||...|.. | .. ||.|
aknrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvkvilsltsdvelnlekcyr

YWPEE
||.| 
YWqeg
0048076 (Phosphotyrosine protein) phosphatases II 1679-1850 7.2e-25 82.8 In-house 1-142 (145) alignment 
Range on Protein: 1679-1850
Range on HMM: 1-142/145.0
QYWPSLGSDPLNVGDLQVSISEEEHKSFGVERTLTLLNPVSDQAREVKHWQFPNWPSSGEMGSGRDLVDLVMRVedyarskvvvpqeesiygnR----Ea
.||||   . | .|.| . .. |. |..|. . |.| .  ..  |.. .... .||  |.  . ..| ...  .                   .    | 
pywpseilpglylgslptaldlellkdlgittvlnltselellerlgiqylylpwpDhgvpdllellleflefi...................eealke.

inehailqQlKPTVVHCSAGVGRTGAYCAAVICLErmkqeNKVDLYQVTKHLRTQRPGMVQTAEQYAFVYRVILDY
          .|..|||||||||||...|| ..|.     ..|.|... ...|.||||.|.. .|. |.|...| .
........g.gpvlVHCsaGvgRtgtlvaaylmll.....lgvsleealelvrsqrpgavpnpgqlrflyefelel
subfamily_egg_pd Subfamily egg 1587-1741 1.6e-24 81.2 In-house 35-189 (307) alignment 
Range on Protein: 1587-1741
Range on HMM: 35-189/307.0
AQQMANKSKNRFQNIMPYDASRVKLSALPGVVGSDYINASYIDGFRQRKQFIATQGPMQSTLADFWRMVWEQEVHSIVMLTHLEESgrQKSEQYWPSLGS
| .  |. | | . .   | |||||    |    |.| | ...|     .|| .| |.. |  ||||||...||. |||||   ||  .. | |||   |
aasdnnlekarskrvhckdssrvklelrrGqylddfihanrvkGkpllnefilaqaplkntvddfwrmvfqeevqyivmltsrkes..erceyywpkaes

DPLNV--GDLQVSISEEEHKS---FGVERtLTLLNPVsDQAREVKHWQFpNWPSSGEMGS
|.| .  | |..   . ..|.   | | . | |. .  |. | ..|||  ..  |... |
dslvtvpGslrienlkvdskadplfrvtk.lklvGgd.deerflehwqg.dvnnssdvys
subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 1300-1530 2e-24 81.2 In-house 18-253 (290) alignment 
Range on Protein: 1300-1530
Range on HMM: 18-253/290.0
RNRQKNRFANILAYdHSRVPLHKLPNDPYSDYINANYIDgYNQPKSYIAAQGPLPHT-------LMDFWRMIWEQRVSVIVMVTNLEEKGRT----KCHR
..  ..| .. |.  ..||.|.   .   .||| ||..  . .    |. | |. ..       . .|| |. . .|  .||. . ||| .      | .
khemdqRlevpLve.atrvvLkgygkrfnddyiHAnrvt.cpnglrliltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCak

YWPEEVGGQLPLtTNMSVFMTKQEEFPDMVIRHLTVQVSQQSR-VVTQFHYISWPDHGVPDSTAGILTTIRRAKetrnqAAAGPMVVHCSAGVGRTGTLI
| ||.||..| .  ...|  ...|.  |. .|.|.|.  ..    ||   . .| .  |...|  .|. |.  |     |   |..|||  |. |  .| 
Yvpesvgeelkf.kgltvkCkskekeddvetRelvvkfddeeeftvtHsllkgWnklnvqedtktllsliqkvk.....asktpvivHcvdGiSrsAala

AIDYNLDKAA-SENKVDVMGSLNEMRRQRTTMVQTEGQYIFIYR
||.    | | ....| .   |...|.|| ...... .. |.  
aiilgyQkiaetsgsvkledvlkalrkqralaitsalelafvda
subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 1585-1737 5.6e-24 79.2 In-house 47-204 (310) alignment 
Range on Protein: 1585-1737
Range on HMM: 47-204/310.0
DAAQQmaNKSKNRFQNIMPYDASRVKLSAlPGVVGSDYINASYIDGFRQRKQFIATQGPMQSTLADFWRMVWEQEVHSIVMLTHLEESGRQKSEQYWPSL
.| ..  .  |||. ...  |.|||||         ||| | |.     |. || .|||.| |. |||||....   ||..| .  | || |.  |||||
eaykk..ymhknrysdvvcldtsrvklki.dksryedyihanyvktnylrstficsqgplqhtiidfwrmifqeraesilllckvgeegrpkcvgywpsl

GSDPlNVGDLQVSISEEEHKSFGV---ERTLTLL-NPVSDQAREVKH-----WQFPNWPSSG
|      | ..|.   |  . | .     |.     || .|  ..|.      ..||||  |
gvte.tygcirvtnlsesseefeicnlavtfvpdnvpvdeqpanlkelrvslikwpnwpdrg
subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 1590-1851 1.3e-23 78.4 In-house 33-270 (285) alignment 
Range on Protein: 1590-1851
Range on HMM: 33-270/285.0
MANKSKNRFQNIMPYDASRVKLSAlpgvVGSDYINASYIDG-FRQRKQFIATQGPMQSTLADFWRMVWEQEVHSIVMLTHLEESGRQKSEQYWPSLGSDP
 ||   ||. ..   . .|| |         ||| ||..    ...  .|.||||.  ||.|||.|......  ..||  | | | .|   |.|    . 
eanpdlnryadvrcieetrvvlkn....hdrdyihaswmrmpgkdqstyittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekcalyypeklgev

LNVGDLQVSISE--EEHKSFGVERTLTLLNPV--SDQAREVKHWQFPNWPSSGEMGSGRDLVDLvmrvedYARSKVVVPQEesiygnreainehailqql
...|  .....|  ||  .  .  .||..|    | .   ..| | | ||        | ...|      |   | | |.|                   
vkfgkyeitlteckeeaiagtilnaltvintedasseplymnhvqvpwwpdqlapedarpmiel......ykwvkkvnpke...................

KPTVVHCSAGVGRTGAYCAAVICLERMKQENKVDLYQVTKHLRTQRPGMVQTAEQYAFVYRVILDYL
|| .|||||||||| ..     .  |. .. .... .. . .|. |   ||.  |. |.| |...|.
kpicvhcsagvgrtatfvgidyatirimenpniemldivremramrfqavqshmqflflyvvlmeyf
subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 1300-1535 2.4e-23 77.2 In-house 46-278 (303) alignment 
Range on Protein: 1300-1535
Range on HMM: 46-278/303.0
RNRQKNRFANILAYDHSRVPLHKlpndpySDYINANYIDgYNQPKSYIAAQGPLPHTLMDFWRMIWEQRVSVIVMVTNLEEKGRTKCHRYWPEEVGGQLP
.| .||||....  |||.| |        | || |.|..  .  |  | .| ||.||  |||.|| ||.| .....    |  .   .  .|..      
knmdknrfvdvicldhskvklsd......ssyihasyle.ldsskkailtqlplshtaadfwqmiieqkvkcvlllltdseydklggdsvfprnqdflkf

LTTNMSVFMTKQEEFPD-MVIRHLTVQVSQQSRVVTQFHYISWPDHGVPDS-TAGILTTIRRAKE-TRNQAAAGPMVVHCSAGVGRTGTLIAIDYN-LDK
    . |   |. |. |  |.. |.|   .    .   || .||   .|   .. ..  | . .   |. . . | |    .|.||.||.  ..   |  
eersirvgefkrvelgdgwvlkvlsvsngdyksflhvhhykawphnsipsdgspkfvkqiwqlqsvlrkysdstptvymslsgcgragtfalfetahlsl

AASENKVDVMGSLNEMRRQRTTMVQTEGQYIFIYRALADG
 . .. .|..  |. .|  |   ||   |. ..|  ||. 
hseqasldlvkclenvrngrlhavqnlsqfsvvytllaeh
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 1566-1761 3.7e-23 77.0 In-house 21-209 (288) alignment 
Range on Protein: 1566-1761
Range on HMM: 21-209/288.0
LDQEFRglsqGPPSSNTRTDAAQQMANKSKNRFQNIMPYDASRVKLSalpgVVGSDYINASYIDGFRQRKQFIATQGPMQSTLADFWRMVWEQEVHSIVM
|..|.|      |  ..   . . .|| ...|..|.   |..|||||         ||.|  .   . ....| .| |...|.  .|.|. |..|. |||
lkkeyr....dspneasidiidsfianptrdryenlprcditrvkls....ddpdfyiaanvvssakykrrlicaqaPlngtieelWkmllesdveyivm

LTHLEESGRQKSEQYWPSLGSDPLNVGDLqVSISEEEHksFGVERTL--TLL--NPVSDQAREVKHWQFPNWPSSGEMGSGRDLVDLVMRVEDYARSKVV
|..| | |..||..|.||   .   .| |  ..  ...   ......  .||  . . ...  ||.  . .|.  |   .    . |. ..... .  ||
lcellekGkeksaeyfPsklGekarigrl.ctvvkkkr..adidklvkvsllriskegeekvivkilhlleWdddgvPenylsplrllevlkslqkPivv
subfamily_eak_pd Subfamily eak 1587-1855 7e-23 75.5 In-house 47-309 (332) alignment 
Range on Protein: 1587-1855
Range on HMM: 47-309/332.0
AQQMANKSKNrFQNIMPYDASRVKLSALpGVVGSDYINASYIDGFRQRKQFIATQGPMQSTLADFWRMVWEQEVHSIVMLTHLEESGRQKSEQYWPSLGS
.... .  .|   .|.|||   |.|..        ||||| ..     ...| |  . .. .  ||.|| ||   .||.| .  | . .||..|.|  . 
tarleavnrn.vvkivpydrylvrltss.qlnrlGyinaslaefsevGrkyiltGiasedkvfafwqmvleqkspaivqlledvelkleksdkyfpdktr

DPLNVGDLQVSISEEEHKSFGVERTLTLlnPVSDQAREVKHWQFPNWPSSgEMGSGRDLVDLVMRVEDYARSKVVVPQEESIygnREAINEHAILQQLKP
. |. | |.|   |  ...    | | |   . ... .|.|...  |    ..   .|.. |   . .    ...|.... .   .  .. .        
eelkfGildverkefvkrniletrllel..skGnethrvlhykvfGwtet.tlpkyedflalrkvmkevGvlllivmksall...sstlkkyihtppsfa

TVVHCSAGVGRTGAYCAAVIcLERMKQENKVDLYQVTKH---LRTQRPGMVQTAEQYAFVYRVILDYLDKQN
 .. .. |  |.|..    . | |. ...| .|| | .     ...|   | .| |..|.| ..|||| ..|
piiqsarGsaraGvfvvidl.lirlidnkkknlysvedlilkvkskrihsvlvalqhsfiyeivldyllrrn
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 1559-1738 9.1e-23 75.3 In-house 19-203 (305) alignment 
Range on Protein: 1559-1738
Range on HMM: 19-203/305.0
VSSGGTQLDQEFRGLSQGP--PSSNTRTDAAQQM-ANKSKNRFQNIMPYDASRVKLSALPgvvGSDYINASYIDG-FRQRKQFIATQGPMQSTLADFWRM
.  |  .| .|||||..      ...  .| |    ...|||.|..   | | |||.  .    |||| | |.   .   |.||..|||.. |. .|| |
ldvgvdklreefrglakytrpdmtqvafnanqsadiaitknryqdvpcqdqsavkldkps...psdyihanyvgcpmipekrficaqgpldqtidefwwm

VWEQEVHSIVMLTHLEESGRQKSEQYWPSLGSDPLNVGD--LQVSISEEEHKSFGVERTLTLLNPV--SDQAREVKHWQFPNWPSSGE
| .. |  |||| .  | |. |  ||||    . |..    .   .|         |  .||||     ||   |.| |. .||  | 
viqnkveqivmlcktvelgklkcaqywpaaqgeklelksgivvenvsgskpmerdaeiqitllnltysgdqkmsvrhlqwtewpdrgv
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 1785-1855 1.1e-22 75.3 In-house 211-281 (315) alignment 
Range on Protein: 1785-1855
Range on HMM: 211-281/315.0
KPTVVHCSAGVGRTGAYCAAVICLERMKQENKVDLYQVTKHLRTQRPGMVQTAEQYAFVYRVILDYLDKQN
 . .|||||||||||  ...  .....|... ||.... | ||..|| .||| |.|||.| ..|..|  .|
fsllvhcsaGvGrtGvvisidevvaqikrtrsvdvfnfvknlrakrpylvqteeeyafiydavledllwrn
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 1784-1855 2.2e-22 74.5 In-house 217-288 (297) alignment 
Range on Protein: 1784-1855
Range on HMM: 217-288/297.0
LKPTVVHCSAGVGRTGAYCAAVICLERMKQENKVDLYQVTKHLRTQRPGMVQTAEQYAFVYRVILDYLDKQN
  | .|||.||||||| ...   .. ..|.|..||.... |.|| .|| .||| |||.||| ..|..|  ..
egPllvhclaGvGrtgvlltidsvvaeakrekevdifglvkklrqerpylvqtkeqykfvyvavleallsed
0048179 (Phosphotyrosine protein) phosphatases II 1680-1845 3.9e-22 74.0 In-house 2-139 (144) alignment 
Range on Protein: 1680-1845
Range on HMM: 2-139/144.0
YWPSLGSDPLNVGDLQVSISEEEHKSFGVERTLTLLNPVSDQAREVK--HWQFPNWPSSGEMGSGRDLVDLVMRVEDYarskvvvpqeesiygnreaine
..||   . | .|.| .... |. |..|.   ..| ..   .  |.   .... .||  |   .  .| ...  .|..                      
snpseilpglylgslptaldlellkklgittvinlteeyepefleregiqylhlpwpDhgvpdllellleflefieea......................

haiLQQLKPTVVHCSAGVGRTGAYCAAVICLermkqENKVDLYQVTKHLRTQRPGMVQTAEQYAFVYR
   |.. .|..|||||||||||...|| ...     .....|... ...|..|||.|.. .|. |...
...leeggpvlVHCsaGvgRtgtlvaaylmk.....klglsleealalvrsrrpgavpnpgqlrfLle
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 1785-1859 4e-22 73.0 In-house 210-284 (515) alignment 
Range on Protein: 1785-1859
Range on HMM: 210-284/515.0
KPTVVHCSAGVGRTGAYCAAVICLERMKQENKVDLYQVTKHLRTQRPGMVQTAEQYAFVYRVILDYLDKQNGAGP
 | ..|||||||||| ....  .. ..|. . ||.... . .| .|| .||| |||||.| ..|..|  .|   |
hpliihcsaGvGrtGvvisidsvvahakttrmvdvfnfvtnirqkrpylvqtqeqyafiygavledllwrntlip
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 1566-1703 6.2e-22 72.9 In-house 8-137 (267) alignment 
Range on Protein: 1566-1703
Range on HMM: 8-137/267.0
LDQEFRGLSQGPPSSNTRTdAAQQMANKSKNRFQNIMPYDASRVKLSAlpgvVGSDYINASYIDGFRQRKQFIATQGPMQSTLADFWRMVWEQEVHSIVM
...||  . .  . |.| .     . |. .||... .||| .|| |.        .||||||..|......||.||.|.. | .||. .. .|.|  ||.
iekefelikkisdtsstis.qsiaeknqernrlddnlpyddtrvilrt....keeeyinasyvegyktknafivtqdplkntitdfltvihdqkvpvivl

LThleESGRQKSEQYWPSLGSDPLNVGDLQVSISEEEH
||    .. ..  ..||    .  .  || |  | |. 
lt...kvftdnirlfwPPkmgqakkyqdltvehsleke
subfamily_PTPN13_pd Subfamily PTPN13 1781-1852 5.6e-21 70.0 In-house 199-270 (273) alignment 
Range on Protein: 1781-1852
Range on HMM: 199-270/273.0
LQQLKPTVVHCSAGVGRTGAYCAAVICLERMKQENKVDLYQVTKHLRTQRPGMVQTAEQYAFVYRVILDYLD
 ..  | |||||||.||.|.. .  . |. .......|. .. ..|| || |.||| .|| |||..||. | 
qtdagPivvhcsaGiGrsGtlitidvvlglierdkefdvkeivrklreqrqgvvqtkdqyifvykailevlk
subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 1344-1530 9e-21 68.9 In-house 5-198 (199) alignment 
Range on Protein: 1344-1530
Range on HMM: 5-198/199.0
KSYIAAQGPLPHTLMDFWRMIWEQRVSVIVMVTNLEEKGRTKCHRYWPEEVGGQLpLTTNMSVFMTKQEEFPDMVIRHLTV----QVSQQSRVVTQFHYI
. |||.| || .|. |||.|.||     |||| . . .  .    |||    |     ...||        ||..|  | .         .| .... . 
rryiatqhplretmadfwqmvwetgsghivmvnddqknkeadypfywpttesgtg.kygslsvttktittkpdytitaliltnnttappstreishyqft

SWPDHGVPDST--AGILTTIRRAKETRNQAAAGPMVVHCSAGVGRTGTLIAIDYNLDKA--ASENKVDVMGSLNEMRRQRTTMVQTEGQYIFIYR
|| ..  |. .   |.. . |      .|    |..|||| | | || ..|.|  .     .    ||..   . .|. |  .. .  .| |||.
swkekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiyq
subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 1344-1530 1e-20 68.8 In-house 4-197 (198) alignment 
Range on Protein: 1344-1530
Range on HMM: 4-197/198.0
KSYIAAQGPLPHTLMDFWRMIWEQRVSVIVMVTNLEEKGRTKCHRYWPEEVGGQLpLTTNMSVFMTKQEEFPDMVIRHLTV----QVSQQSRVVTQFHYI
. |||.| || .|| |||.|.||     |||| . . .  .    |||    |     ...||        ||..|  | .         .| .... . 
rryiatqhplretladfwqmvwetgsghivmvnddqknkeadypfywpttesgtg.kygslsvttktittkpdytitaliltnnttappstreishyqft

SWPDHGVPDST--AGILTTIRRAKETRNQAAAGPMVVHCSAGVGRTGTLIAIDYNLDKA--ASENKVDVMGSLNEMRRQRTTMVQTEGQYIFIYR
|| ..  |. .   |.. . |      .|    |..|||| | | || ..|.|  .     .    ||..   . .|. |  .. .  .| |||.
swkekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiyq
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 1781-1849 1.6e-20 68.6 In-house 221-289 (319) alignment 
Range on Protein: 1781-1849
Range on HMM: 221-289/319.0
LQQLKPTVVHCSAGVGRTGAYCAAVICLERMKQENKVDLYQVTKHLRTQRPGMVQTAEQYAFVYRVILD
 .. .. ||||||||||||.| .  . |.|||.|..||.|.. . || ||. .||   || |.|  .|.
enhranivvhcsaGvGrtGvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalle
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 1584-1752 3.3e-20 67.0 In-house 40-215 (305) alignment 
Range on Protein: 1584-1752
Range on HMM: 40-215/305.0
TDAAQQMANKSKNRFQNIMPYDASRVKLsalPGVVGSDYINASYIDGFRQRKQFIATQGPMQSTLADFWRMVWEQEVHSIVMLTHLEESGRQKSEQYWPS
  | ..  .. |||....   |  ||||    |    .|| | |.    . |.|| || |.. | |||| | ... |..| ||  | | | .|  .|..|
mkafkeaqeagknrykdvgcldnnrvkl...egpwpheyihanyvstptnpkrfictqaplektcadfwymclqdkveaifmlcnllekgakkcleyfas

LGSDPLNVG--DLQVSISEEEH--------KSFGVERTLTLLNPVSDQAREVKHWQFPNWPSSGEMGSGRDLVDLVMRV
   | |.    . ..|.  |           .  |..|  ...    .|| |.|. . .||  |   .   ...|. . 
kdkdvlefeekgqkisvkfessvtlkfrkdakakvtetvlviegpgekarkvthyhwidwpdrgvpaadlailelleka
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 1781-1849 3.7e-20 67.6 In-house 185-253 (284) alignment 
Range on Protein: 1781-1849
Range on HMM: 185-253/284.0
LQQLKPTVVHCSAGVGRTGAYCAAVICLERMKQENKVDLYQVTKHLRTQRPGMVQTAEQYAFVYRVILD
 .. .. ||||||||||||.| .  . |.|||.|..||.|.. . || ||. .||   || |.|  .|.
enhranivvhcsagvgrtgvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalle
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 1784-1852 9e-20 65.8 In-house 192-260 (267) alignment 
Range on Protein: 1784-1852
Range on HMM: 192-260/267.0
LKPTVVHCSAGVGRTGAYCAAVICLERMKQENKVDLYQVTKHLRTQRPGMVQTAEQYAFVYRVILDYLD
 .| ||.||.||||.|..  .   |||.|.|. .|...  ...| ||.|.|.| |.| ...... .| .
nrPlvvacsdGvGrsGtflvidsqleraktegvsdifdflrkirsqriglvdtkeryiyihellaeyae
subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 1356-1528 1e-19 65.6 In-house 40-213 (255) alignment 
Range on Protein: 1356-1528
Range on HMM: 40-213/255.0
TLMDFWRMIWEQRVSVIVMVTNLEEKGRTKCHRYWPEEVGGQLPLtTNMSVFMTKqeEFPDMVIR--HLTVQVS--QQSRVVTQFHYISWPDHGVPDSTA
|.  |...|  .. .|.||.....|.|. ||..|.| |  ..| | ....|  ||     |.|.|  ..| ...  .. . |. ..|  |...  |. . 
tvdkfyqtivqtktevvvmlcdfaeegvekcssyfplekdeklkl.advnvtttk..ssadvvlrtleitstlgekkkthtvkhysykGWieknaPelar

GILTTIRRAKETRnqaaagPMVVHCSAGVGRTGTLIAIDYNLD------KAASENKVDVMGSLNEMRRQRTTMVQTEGQYIFI
 ||  .. .....      ..|||||.|.||. ... ...         . ..  ..| .  |.|.| .|.. ..|  |  | 
eilnilkvvrdsk......svvvhCstGiGrsaafvlaelvyqkmirsldttetveldylslleelrskrkraihtPlqlafs
subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 1299-1534 3e-19 63.5 In-house 49-283 (302) alignment 
Range on Protein: 1299-1534
Range on HMM: 49-283/302.0
DRNRQKNRFANILAYDHSRVPLHKLPNdpysDYINANYIDGYNQPKSYIAAQGPLPHTL---MDFWRMIWEQRVSVIVMVTNLEEKGRtKCHRYWPEEVG
 .| .||.  .. ..|. .| |.. |.    .|.||  ..  .  .| | || |   .     .||||......  .|..   ||  .   . ..|.. |
kknlkknqsedvpildsnlvkleaepd....syvnaskvevPeltrsiilaQlpkvdsedsveeFWrmvfqekivsvvilvgeeelkk.tlselfpkksg

GqLPLTTNMSVFMTKQEEFPDMViRHLTVQVS----QQSRVVTQFHYISWPDHGVPDSTAGILTTIRRAkETRNQAAAGPMVVHCSAGVGRTGTLIAIDY
       .| |   | |.  ...  .... |      .| ...  .   |... ||.. | . .|.     .... |  ..|.    |.|| |....   
d.ykeygkmfvNnrkVekaeeek.tryviEvlPegcsnsvlanvyvltnWkqkkvpvkyaeliktaakv.fakkikadentvivSknGaGRagafltlav

NLDKAASENKVDVMGSLNEMRRQRTTMVQTEGQYIFIYRALAD
 ..|  ..... .   .. .| ||...|..  ||...|.||. 
aveklqkgkepnikeivksiRsqRpravdslkQyvslyialll
subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 1622-1755 3.5e-19 63.6 In-house 77-213 (301) alignment 
Range on Protein: 1622-1755
Range on HMM: 77-213/301.0
YINASYIDGFRQRKQFIATQGPMQSTLADFWRMVWEQEVHSIVMLTHLEESGRQKSEQYWPSLGSDPLNVGDLQVSISEEEH--KSFGVERTLTLLNPVS
 | | .|.   . ..|||||||...|  ||| |.   .|. ||||..  |   .| |.| |.  |. |..|  .. | ..|.  .   ..||| . .   
PihanwiptsGhphrfiatqgPlkntsedfwamlvqydvekivmlgqkvekleekceeylpvkisekldigrfkikiknkelilnkkiskrtlevedstg

D-QAREVKHWQFPNWPSSGEMGSGRDLVDLVMRVEDY
. ..| | |.|. .|.  |   |  .| ||.  | . 
kfatrtvthyqysewtdrgvPkshaelfdlmelvkks
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 1788-1854 1.7e-18 61.2 In-house 322-388 (392) alignment 
Range on Protein: 1788-1854
Range on HMM: 322-388/392.0
VVHCSAGVGRTGAYCAAVICLERMKQENKVDLYQVTKHLRTQRPGMVQTAEQYAFVYRVILDYLDKQ
.||| .| |||| .|.|. |. .. . . ||..|  | ||..|  .||| |.||||| || .||  .
lvhclsgagrtgvfctameciaqiaegdsvdifqtvkilradrmqfvqteeeyafvydvireylhte
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 1303-1392 2.1e-17 57.5 In-house 50-155 (349) alignment 
Range on Protein: 1303-1392
Range on HMM: 50-155/349.0
QKNRFANILAYDHSRVPLHKLPNDPY--------------SDYINANYID--GYNQPKSYIAAQGPLPHTLMDFWRMIWEQRVSVIVMVTNLEEKGRTKC
 |||. .|| |.|||| |.| .. .                |||||||.    ..  | ||| | ||| |. ||...|  ..| ... ... .|..  ||
aknrykdilPyehsrvklkkslksskvikastsesdsgklddyinanylkltrisvekkyiatqaPlPstvddfykvillngvklvlsLnddkelslekc

HRYWPE
..|| |
diywqe
subfamily_CG42327_pd Subfamily CG42327 1465-1533 2.5e-17 57.5 In-house 243-312 (319) alignment 
Range on Protein: 1465-1533
Range on HMM: 243-312/319.0
NQAAAGPMVVHCSAGVGRTGTLIAIDYNLDKAASE-NKVDVMGSLNEMRRQRTTMVQTEGQYIFIYRALA
..   ||.||||| ||||||..|| | .. .     . ||.   .  .||.|.  |.|  || |||. | 
tresqGPlvvhcsdGvGrtGlviasdiairsleeskrsvdiPqlvssvrrdrasavltkeqyefiykvls
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 1430-1532 3.1e-17 57.3 In-house 214-340 (350) alignment 
Range on Protein: 1430-1532
Range on HMM: 214-340/350.0
SRVVTQFHYISWPDHGVPDSTAGILTTIR---------RAKETRNQAAAGPMVVHCSAGVGRTGTLIAIDYNLD-------KAASENKVDVMG-------
  || |...  |.| ..      ||...           |..  ..| . |..|||||||||||||...|. |             .|.||.        
PyvvyqlqvknWkDlslllnPesilqalevkndliddlfaeshldnarsspilvhCsaGvGrtGtlvtlDsllsdfeilenltkesrkldvaaktrDlis

-SLNEMRRQRTTMVQTEGQYIFIYRAL
  .||.|.||  |||.  |.|||| ||
iivnelrkqrismvqnldqfifiYeal
subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 1587-1738 4.4e-17 56.5 In-house 91-235 (244) alignment 
Range on Protein: 1587-1738
Range on HMM: 91-235/244.0
AQQMANKSKNRFQNIMPYDASRVKLSAlpGVVGSDYINASYIDGFRQRKQFIATQGPMQSTLADFWRMVWEQEVHSIVMLTHLEESgrqksEQYWPSlgS
| .  |  |||    .|.| .|| ||   | .|  |||||..  . .  ..| || |.  |  |||.|. |. |  .|.|  .||      ..|||   |
afnpnnswknregaglpfdfnrvplsk..gsmgntyinasfvgclgrtaeyiltqhpladtsmdfwkmmlerhvnvlvvlgsveee.....deywpd..s

DPLNVG--DLQVSISE-EEHKSFGvERTLTLLNPVSDQAREVKHWQFPNWPSSGE
.||.    |. |.... .| |       | .   . .  . .  .|  |||| | 
eplewyeeditvtltdrdefknik.asnleiesdmneshqaltmfqisnwpsdgt
subfamily_hpo-7_pd Subfamily hpo-7 1353-1532 1.3e-16 55.4 In-house 43-223 (263) alignment 
Range on Protein: 1353-1532
Range on HMM: 43-223/263.0
LPHTLMDFWRMIWEQRVSVIVMVTNLEEKGRTKCHRYWPEEVGGQLPLtTNMSVFMTKQEEfpDMVIRH--LTVQVS--QQSRVVTQFHYISWPDHGVPD
|  |.  |...|  .. .|.||... .|.|. || .|.| |  ... | .|..|  ||  .  |....   |. ...  .. . |... |  |...  | 
lvqtidkfyqtivqtktevvvmLcDfneegvekcssyfPlekdekqkl.anvnvcttkvqs..dvllktlellstlgeKkkthtvkhysykgWiekndpe

STAGILTTIRRAKETRnqaaagPMVVHCSAGVGRTGTLIAIDYNLD------KAASENKVDVMGSLNEMRRQRTTMVQTEGQYIFIYRAL
 .  ||  .. |.. .      ..|||||.|.||.     ..          . .|  ..| .  |.|.| .|.. ..|  |  |    .
lareilnilkvarnsk......slvvhcstGiGrsaafsvaElvyqkmirsldttstveldylsLleelrssrkraihtPmqLafsilmv
subfamily_Sponge-PTP-7_pd Subfamily Sponge-PTP-7 1472-1536 1.4e-16 54.6 In-house 1-65 (69) alignment 
Range on Protein: 1472-1536
Range on HMM: 1-65/69.0
MVVHCSAGVGRTGTLIAIDYNLDKAASENKVDVMGSLNEMRRQRTTMVQTEGQYIFIYRALADGL
||||||.| |||||.|||  .. .  ||  ||..  .. ||. |  ||  | .||||. ||.. |
mvvhcssgtgrtgtfiaimvemarikseklvdifnnvqymrkcrpmmvmneieyifihdalveal
subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 1298-1446 2.1e-16 54.3 In-house 93-235 (244) alignment 
Range on Protein: 1298-1446
Range on HMM: 93-235/244.0
MDRNRQKNRFANILAYDHSRVPLHKLPNdpYSDYINANYIDGYNQPKSYIAAQGPLPHTLMDFWRMIWEQRVSVIVMVTNLEEKgrtkcHRYWPEEVGGQ
   |  ||| .  | .| .|||| |        |||| ..    .   || .| ||  | ||||.|. |. | |.|..  .||.       |||.    .
npnnswknregaglpfdfnrvplskgsm..gntyinasfvgclgrtaeyiltqhpladtsmdfwkmmlerhvnvlvvlgsveee.....deywpdseple

LpLTTNMSVFMTKQEEFPDMVIRHLTVQ--VSQQSRVVTQFHYISWPDHGV
     ...| .| ..|| ..    | ..  . .  . .| |    ||  | 
w.yeeditvtltdrdefknikasnleiesdmneshqaltmfqisnwpsdgt
subfamily_Sponge-PTP7_pd Subfamily Sponge-PTP7 1473-1536 1.2e-15 51.6 In-house 1-64 (69) alignment 
Range on Protein: 1473-1536
Range on HMM: 1-64/69.0
VVHCSAGVGRTGTLIAIDYNLDKAASENKVDVMGSLNEMRRQRTTMVQTEGQYIFIYRALADGL
|||||.| |||||.|||  .. .  ||  ||..  .. ||. |  ||  | .|.||. ||.. |
vvhcssGtGrtGtfiaimvemarikseklvdifnnvqymrkcrpmmvmneneymfihdalveal
subfamily_CG42327_pd Subfamily CG42327 1781-1851 1.2e-15 52.0 In-house 244-315 (319) alignment 
Range on Protein: 1781-1851
Range on HMM: 244-315/319.0
LQQLKPTVVHCSAGVGRTGAYCAAVICLERMKQE-NKVDLYQVTKHLRTQRPGMVQTAEQYAFVYRVILDYL
 ..  | ||||| ||||||   |. | ......  . ||. |.  ..| .|   |.| |||.|.|.|.  | 
resqGPlvvhcsdGvGrtGlviasdiairsleeskrsvdiPqlvssvrrdrasavltkeqyefiykvlseya
subfamily_Sponge-PTP3_pd Subfamily Sponge-PTP3 1257-1351 1.6e-15 51.1 In-house 4-95 (95) alignment 
Range on Protein: 1257-1351
Range on HMM: 4-95/95.0
EISVSDLNTVIQQMAANSDFAFSEEYECIESGSEFGRNYAIMDRNRQKNRFANILAYDHSRVPLHKlpnDPYSDYINANYIDGYNQPKSYIAAQG
 | || . . . .| .|||  | .|.  |   |         . |  |||| ||. || .|| |        |||||| ..||| . . ||||||
pihvsvfhshvlemhsnsdqefdnefksismtsgapytvgsseanipknrflnifpydatrvvltt...krdsdyinacfvdgyarkncyiaaqg
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 1590-1685 4.9e-15 49.7 In-house 46-157 (349) alignment 
Range on Protein: 1590-1685
Range on HMM: 46-157/349.0
MANKSKNRFQNIMPYDASRVKLSALP--------------GVVGSDYINASYID--GFRQRKQFIATQGPMQSTLADFWRMVWEQEVHSIVMLTHLEESG
.   .|||...|.||. |||||   .              . .  ||||| |.    .   |..|||| |. ||. ||....  ..|. .. |.. .| .
velfaknrykdilPyehsrvklkkslksskvikastsesdsgklddyinanylkltrisvekkyiatqaPlPstvddfykvillngvklvlsLnddkels

RQKSEQYWPSLG
 .| ..||  | 
lekcdiywqels
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 1774-1851 5.2e-15 50.2 In-house 198-277 (307) alignment 
Range on Protein: 1774-1851
Range on HMM: 198-277/307.0
AINE-HAILQQLKPTVVHCSAGVGRTGAYCAAVICLERMK-QENKVDLYQVTKHLRTQRPGMVQTAEQYAFVYRVILDYL
|||  .|.  .  | ||||||||||.|.  |  .  ..|   .|  |. .. . ||.||.  .||  || ...||.|.|.
ainlleavrydtnpvvvhcsaGvGrsGtivaislvqdkmiaGinckdmkklveelrsqrhyaiqteaqylylhrvlleyf
subfamily_Cele-PTP-12_pd Subfamily Cele-PTP-12 1294-1385 8.6e-15 49.0 In-house 27-117 (332) alignment 
Range on Protein: 1294-1385
Range on HMM: 27-117/332.0
NYAIMDRNRQKNRFANILAYDHSRVPLHklPNDPYSDYINANYIDGYNQPKSYIAAQGPL-PHTLMDFWRMIWEQRVSVIVMVTNLEEKGRTK
 |  .  | . ||   . ..||||| |   |.|   |. ||...|||..  .|| || |.  ||   ||||. |.. |.|... ...|| . |
tydkflnnmdmnriphlycfdhsrvela..pqdgkddfynaswvdgyskksayifaqapfndhteyvfwrmvserkpsmilvfgdidekqkrk
subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 1587-1753 1.3e-13 45.3 In-house 42-202 (303) alignment 
Range on Protein: 1587-1753
Range on HMM: 42-202/303.0
AQQMANKSKNRFQNIMPYDASRVKLSAlpgvvgSDYINASYIDgFRQRKQFIATQGPMQSTLADFWRMVWEQEVHSIVMLTHLEESGRQKSEQYWPSlGS
 | . |  |||| ...  | |.||||       | || |||.. .  .|. | || |.. | ||||.|. || |. ...|    |  .   .  .|    
nqfvknmdknrfvdvicldhskvklsd......ssyihasyle.ldsskkailtqlplshtaadfwqmiieqkvkcvlllltdseydklggdsvfpr.nq

DPLNVGDLQVSISEEEHKSFGVERTLTLLNPVSDQAREVKH-WQFPNWPSSGEMGSG-RDLVDLVMRVE
| |.  .  . . |  .  .|   .| .|     . .   |  .. .|| .   . |   .|  . ...
dflkfeersirvgefkrvelgdgwvlkvlsvsngdyksflhvhhykawphnsipsdgspkfvkqiwqlq
subfamily_Sponge-PTP3_pd Subfamily Sponge-PTP3 1563-1642 1.9e-13 44.4 In-house 22-95 (95) alignment 
Range on Protein: 1563-1642
Range on HMM: 22-95/95.0
GTQLDQEFRGLSQGppsSNTRTDAAQQMANKSKNRFQNIMPYDASRVKLSAlpgVVGSDYINASYIDGFRQRKQFIATQG
  ..|.||. .|     | .   .    ||  |||| ||.||||.|| |..      |||||| ..||. ... .||.||
dqefdnefksismt...sgapytvgsseanipknrflnifpydatrvvltt...krdsdyinacfvdgyarkncyiaaqg
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 1777-1851 3.3e-13 43.7 In-house 120-194 (440) alignment 
Range on Protein: 1777-1851
Range on HMM: 120-194/440.0
EHAILQQLKPTVVHCSAGVGRTGAYCAAVICLERMKQENKVDLYQVTKHLRTQRPGMVQTAEQYAFVYRVILDYL
|        | .||||||.||||   |    |   |. ...|.. . . .| .|| |||| ||||||. ..|. |
esqekagngpllvhcsagagrtgviiavdsilreakrsdqidifsfinsmrnnrpqmvqtpeqyafvheavlegl
subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 1634-1734 4.6e-13 43.8 In-house 4-106 (199) alignment 
Range on Protein: 1634-1734
Range on HMM: 4-106/199.0
RKQFIATQGPMQSTLADFWRMVWEQEVHSIVMLTHLEESGRQKSEQYWPSLGSDPLNVGDLQVSISEEEHKSFGVERTLTLLNPV--SDQAREVKHWQFP
....|||| |.. |.||||.||||     |||.   .         |||.  |   . | | |.      |.  .  .| | | .     .||. |.|| 
qrryiatqhplretmadfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqft

NWP
 | 
swk
subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 1634-1734 5.8e-13 43.5 In-house 3-105 (198) alignment 
Range on Protein: 1634-1734
Range on HMM: 3-105/198.0
RKQFIATQGPMQSTLADFWRMVWEQEVHSIVMLTHLEESGRQKSEQYWPSLGSDPLNVGDLQVSISEEEHKSFGVERTLTLLNPV--SDQAREVKHWQFP
....|||| |.. ||||||.||||     |||.   .         |||.  |   . | | |.      |.  .  .| | | .     .||. |.|| 
qrryiatqhplretladfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqft

NWP
 | 
swk
subfamily_Sponge-PTP-4_pd Subfamily Sponge-PTP-4 1602-1738 7.3e-13 43.0 In-house 3-126 (130) alignment 
Range on Protein: 1602-1738
Range on HMM: 3-126/130.0
MPYDASRVKlsalpgvvGSDYINASYIDGFRQRKQFIATQGPMQSTLADFWRMVWEQEVHSIVMLTHLEESgrqksEQYWPSlgSDPLN--VGDLQVSIS
.... ||..        | .|||||..    . .... || |.  |  |||.|. |. |  .|.|  .||      ..|||   |.||.    |. |...
lefevsrlq........gntyinasfvGllgrtaeylltqhpladtsmdfwkmmleryvnvlvvlgsveee.....deywpd..sePlewyeediivtlt

EEEHKSFGVERTLTLLNPVSDQAREVKHWQFPNWPSSGE
. .   .     |   . . .  . .  .|  |||| | 
drdefknikasnleiesdlneshqaltmfqisnwpsdgt
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 1427-1532 8.1e-13 42.4 In-house 213-340 (349) alignment 
Range on Protein: 1427-1532
Range on HMM: 213-340/349.0
SQQS-RVVTQFHYISWPDHGVPDSTAGILTTIR---------RAKETRNQAAAGPMVVHCSAGVGRTGTLIAIDYNLD----KAASENKVDVM-------
....  .. |. .  |.| ..      ||...           |.   ...   ...|||||| ||||.|. .|. |.         ||...        
avekPyellqlqvknwldlslllnPisilqalevkndliddlfarlyldtdqlstllvhcsaGcGrtGvlvtldlllsileplqnesnkiklqallkDli

-GSLNEMRRQRTTMVQTEGQYIFIYRAL
  ..||.|.||  |||   |.|.|| ||
siivnelrkqrismvqnlaqfiaiyeal
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 1784-1852 1.7e-12 41.6 In-house 221-290 (305) alignment 
Range on Protein: 1784-1852
Range on HMM: 221-290/305.0
LKPTVVHCSAGVGRTGAYCAAVICLERMKQENKV-DLYQVTKHLRTQRPGMVQTAEQYAFVYRVILDYLD
  | |||||||.||||.  |    ||.. .....  . .. | || ||   .|.  || |..||.|.|. 
kvpivvhcsagigrtgtivaieyilekiaenkpcppmpelvkalrdqrafsiqndvqylfihrvmlnyfl
subfamily_Sponge-PTP-7_pd Subfamily Sponge-PTP-7 1788-1848 1.7e-12 41.5 In-house 2-62 (69) alignment 
Range on Protein: 1788-1848
Range on HMM: 2-62/69.0
VVHCSAGVGRTGAYCAAVICLERMKQENKVDLYQVTKHLRTQRPGMVQTAEQYAFVYRVIL
|||||.| ||||.. | .. . |.| |  ||..   ...|  || ||    .| |..  . 
vvhcssgtgrtgtfiaimvemarikseklvdifnnvqymrkcrpmmvmneieyifihdalv
subfamily_Sponge-PTP-4_pd Subfamily Sponge-PTP-4 1311-1446 2e-12 41.5 In-house 3-126 (130) alignment 
Range on Protein: 1311-1446
Range on HMM: 3-126/130.0
LAYDHSRVPlhklpndpYSDYINANYIDGYNQPKSYIAAQGPLPHTLMDFWRMIWEQRVSVIVMVTNLEEKgrtkcHRYWPEEVggqlP---LTTNMSVF
| .. ||..          .||||...   .. . |. .| ||  | ||||.|. |. | |.|..  .||.       |||.      |     ... | 
lefevsrlq........gntyinasfvGllgrtaeylltqhpladtsmdfwkmmleryvnvlvvlgsveee.....deywpdse....Plewyeediivt

MTKQEEFPDMVIRHLTVQVS--QQSRVVTQFHYISWPDHGV
.|...||  .   .| ..    .  . .| |.   ||  | 
ltdrdefknikasnleiesdlneshqaltmfqisnwpsdgt
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 1725-1851 2.5e-12 41.2 In-house 217-344 (350) alignment 
Range on Protein: 1725-1851
Range on HMM: 217-344/350.0
VKHWQFPNWPSSGEMGSGRDLVDLVMrvedyarskvvvpQEESIYGNREAiNEHAILQQLKPTVVHCSAGVGRTGAYCAAVICLE------RM-KQENKV
| . |. ||. .. .   ....  .                . .  .  | ..|   ....| .||||||||||| ...    |.       . |. .|.
vyqlqvknWkDlslllnPesilqale.............vkndliddlfa.eshldnarsspilvhCsaGvGrtGtlvtlDsllsdfeilenltkesrkl

DL--------YQVTKHLRTQRPGMVQTAEQYAFVYRVILDYL
|          .. ..|| ||  |||. .|. |.|  .| | 
dvaaktrDlisiivnelrkqrismvqnldqfifiYeallfyf
subfamily_Sponge-PTP7_pd Subfamily Sponge-PTP7 1788-1848 2.9e-12 40.7 In-house 1-61 (69) alignment 
Range on Protein: 1788-1848
Range on HMM: 1-61/69.0
VVHCSAGVGRTGAYCAAVICLERMKQENKVDLYQVTKHLRTQRPGMVQTAEQYAFVYRVIL
|||||.| ||||.. | .. . |.| |  ||..   ...|  || ||   ..| |..  . 
vvhcssGtGrtGtfiaimvemarikseklvdifnnvqymrkcrpmmvmneneymfihdalv
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 1783-1851 3.6e-12 40.9 In-house 203-271 (288) alignment 
Range on Protein: 1783-1851
Range on HMM: 203-271/288.0
QLKPTVVHCSAGVGRTGAYCAAVICLERMKQENKVDLYQVTKHLRTQRPGMVQTAEQYAFVYRVILDYL
  || |||.||||||||.    .| || .. .. . . .. ..|| .|   .||  || .|.|..|..|
lqkPivvhssaGvGrtgtlililialeslrlddflgirsllaklreerfkaiqtemqylyvhrcvleel
0038934 (Phosphotyrosine protein) phosphatases II 1431-1525 4.1e-12 41.6 In-house 59-166 (194) alignment 
Range on Protein: 1431-1525
Range on HMM: 59-166/194.0
RV------------------VTQFHYISWPDHGVPDSTAGILTTIRRAKETRNQAAAGPMVVHCSAGVGRTGTLIAIDYNLDkaaseNKVDVMGSLNEMR
 |                    ... . .||.|.. |.. .|. .. ..|  |. . |  .||| ||.||||||.|           .. ..  ... .|
lvidltnteryYdpeefekagieylklpfpddgtvPsleillrfldlvdeflnedpggvvaVHCkaGlgRtGtlvaaYLiyr.....lgmsaeeAialfr

RQRTTMVQTEGQY
. |  .... ...
ekRpgaipnqdyl
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 1785-1854 4.6e-12 40.3 In-house 220-290 (305) alignment 
Range on Protein: 1785-1854
Range on HMM: 220-290/305.0
KPTVVHCSAGVGRTGAYCAAVICLERMKQENKVD-LYQVTKHLRTQRPGMVQTAEQYAFVYRVILDYLDKQ
 |.|||||||.||||.       |... . ....   .. ...| ||   .|| .|| ||..|||.|. |.
gpivvhcsagigrtgsvvmleyildqllagqiiedtdkilqkireqrnnsiqtdaqylfvhqvilnyfrkk
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 1785-1850 4.9e-12 40.1 In-house 217-282 (290) alignment 
Range on Protein: 1785-1850
Range on HMM: 217-282/290.0
KPTVVHCSAGVGRTGAYCAAVICLERMKQENKVDLYQVTKHLRTQRPGMVQTAEQYAFVYRVILDY
 | |||||||.||||.. |  ..|. . .  ..|| .. . ||  | . ||   ||  . ...||.
GpvvvhcsaGiGrtGtfvaievglqilldGkeldlldlvralrnsrlnsvqvdiqylalveilldl
subfamily_Sponge-PTP-2_pd Subfamily Sponge-PTP-2 1293-1451 6.5e-12 38.7 In-house 19-159 (169) alignment 
Range on Protein: 1293-1451
Range on HMM: 19-159/169.0
RNYAIMDRNRQKNRFANILAYDHSRVPLHKLPNDPYSDYINAnyidgynqpksyiaaqgplphtlmdfwRMIWEQRVSVIVMVTNLEEKgrtkcHRYWPE
   | .  |  ||| |  ||  | || |... .|  ||||||                           |||||   ||||.. . ..|       .|||
nfmaeltcnetknrpagplapshtrvklqrvmedlgsdyina...........................rmiwetnasvivvlgdtddk.....nnfwpe

EVGGQLPLTTNMS--------VFMTKQEEFPDMVI--RHLTVQVSQQSRVVT----QFHYISWPDHGVPDSTA
    ||  .  .         |   | .   . |    .... . . .. ||     .|| .||. |||.|  
kedyqlhpavilgewytdslyvrtdkvhantsgveglfevsmvihsydddvteklsllhystwpqngvpqspv
subfamily_Sponge-PTP2_pd Subfamily Sponge-PTP2 1294-1451 8e-12 38.3 In-house 19-158 (169) alignment 
Range on Protein: 1294-1451
Range on HMM: 19-158/169.0
NYAIMDRNRQKNRFANILAYDHSRVPLHKLPNDPYSDYINAnyidgynqpksyiaaqgplphtlmdfwRMIWEQRVSVIVMVTNLEEKgrtkcHRYWPEE
  | .  |  ||| |  ||  | || |... .|  ||||||                           |||||   ||||.. . ..|       .||| 
fmaeltcnetknrpagplapshtrvklqrvmedlgsdyina...........................rmiwetnasvivvlGdtddk.....nnfwpek

VGGQLPLTTNMSVFMT--------KQEEFPDMVI--RHLTVQVSQQSRVVTQ----FHYISWPDHGVPDSTA
   ||  .  .  . |        | .     |    .... . . .. ||.    .|| .||. |||.|  
edyqlhpavilGewytdslyvrtdkvhpntsgveglfevslvihsydddvteqlsllhystwpqngvpqspv
fn3 Fibronectin type III domain 489-591 1.1e-11 37.9 Pfam-A 2-84 (85) alignment 
Range on Protein: 489-591
Range on HMM: 2-84/85.0
AVRAVDLSDSSDQSLMFSITPPRseDQNGPELRYLITYQANSANSdfayriqdgglrtapdeLAATGTIDGAVTRVRLSSLQPYMEYRITVRASNGNGlN
|.. . .|. .. ||..| .||.  |..||  .| ..|.  . ..                    . |...  |.| |. |.|..||...|.| ||.| .
aPenlsvsevtstsltlsWsppk..dgggpitgYeveyrekggge.................ewkeftvprtttsvtltgLkpgteYefrVqavngag.e

GPE
|||
gpe
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 1258-1340 1.4e-11 38.4 In-house 6-86 (440) alignment 
Range on Protein: 1258-1340
Range on HMM: 6-86/440.0
ISVSDLNTVIQQMAanSDFAFSEEYECIESGSEFGRNYAIMDRNRQKNRFANILAYDHSRVPLHKLPNDPYSDYINANYIDGY
| |.|.   .|.       || .|.  . ||     . | .  |. |||. |||||||||| |...   | |||||| ||.| 
iivadfadyvqnnr..rsrafedewsllpsglsqpsdiaslpnnkvknryrnilaydhsrvmleevkgvpdsdyinasyingi
subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 1785-1854 1.4e-11 38.4 In-house 219-288 (302) alignment 
Range on Protein: 1785-1854
Range on HMM: 219-288/302.0
KPTVVHCSAGVGRTGAYCAAVICLERMKQENKVDLYQVTKHLRTQRPGMVQTAEQYAFVYRVILDYLDKQ
..||.    |.|| ||  .... .|........   .. | .|.||| .|....||...|...| |. |.
entvivSknGaGRagafltlavaveklqkgkepnikeivksiRsqRpravdslkQyvslyialllyikkk
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 1630-1758 2.2e-11 37.7 In-house 231-356 (440) alignment 
Range on Protein: 1630-1758
Range on HMM: 231-356/440.0
GFRQRKQFIATQGPMQSTLADFWRMVWEQEVHSIVMLTHLEEsgrQKSEQYWPSlGSDPLNVGDLQVSISEEEHKSFGVERTLTLLNP-VSDQAREVKHW
|. ... ||||| |..||. ||||.| . .. .|.||  |..   .    |||   .  .  | . |     |       ||| |       . |. .  
gyskknafiatqmpldstvldfwrlvhdyristiimlnqlnd...ktcsiywpv.ntrsvtfgpftvghkgsenmnrvkvrtlelkykeevheirqfevq

QFPNWPSSGEMGSGRDLVDLVMRVEDYARS
 .| |  |  . |  . .| |... || | 
twptwiqsdgvqsqeqcmdavlqlmdylrk
subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 1784-1850 3.9e-11 37.1 In-house 200-268 (281) alignment 
Range on Protein: 1784-1850
Range on HMM: 200-268/281.0
LKPTVVHCSAGVGRTGAYCAAVICLERMKQENK-VDLYQVTKHLR-TQRPGMVQTAEQYAFVYRVILDY
  | |.||||||||.|.  |  |.|. ..      |. |.  ||| | |   ||| .|| ....|.||.
stppvihcsagvgrsgtlmaveialqsihshftlpdikqivshlrvtgraasvqtlqqymliwkvlldf
subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 1595-1762 8.5e-11 36.5 In-house 22-196 (290) alignment 
Range on Protein: 1595-1762
Range on HMM: 22-196/290.0
KNRFQNIMpYDASRVKLSALPGVVGSDYINASYIDgFRQRKQFIATQGPM-------QSTLADFWRMVWEQEVHSIVMLTHLEESGRQKSE----QYWPS
..| .. .   |.|| |        .||| |...  . .  ..|.|| |        .||. .|| |. . .|...|||   ||  ...|.    .| | 
dqRlevpL.veatrvvLkgygkrfnddyiHAnrvt.cpnglrliltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCakYvpe

LGSDPLNVGDLQVSISEEEHKSFGVERTLTLLNpVSDQAREVKHWQFPNWPSSGEMGSGRDLVDLVMRVEdYARSKVVV
   . |....|.|.  . |..    .|.|..     ..   |.| .. .| ..    . . |..|.. |.   .. |.|
svgeelkfkgltvkCkskekeddvetRelvvkf.ddeeeftvtHsllkgWnklnvqedtktllsliqkvk.asktpviv
subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 1589-1741 8.6e-11 36.1 In-house 40-194 (312) alignment 
Range on Protein: 1589-1741
Range on HMM: 40-194/312.0
QMANKSKNRFQNIMPYDASRVKLSAlpgvVGSDYINASYIDGFRQRKQFIATQGPMQSTLADFWRMVWEQEVHSIVMLTHLEESGRQKSEQYWPSLgSDP
 .  |  ||. ||  .|  |  |.         || | ..    . ..|..||||...| . ||...      ||..|. . | | .|. .|   .    
flkfkdlnrypniqcwdrgrftlag....denfyihanfvkictkperfvctqgplentcthfwqlalslgstsiillcgfvedgsekcakyisdi.vgf

LNVGDLQVSISE---E----EHKSFGVERTLTLLNPVSDQAREVKHWQFPNWPSSGEMGS
... | .|              |     | | ..   . |   ..|.|.  ||  |   |
vdledhrvyteycteieiggkskdkithrvlkvvvkatgqesklnhyqwaswpdhgmpds
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 1470-1531 1.3e-10 35.7 In-house 229-290 (297) alignment 
Range on Protein: 1470-1531
Range on HMM: 229-290/297.0
GPMVVHCSAGVGRTGTLIAIDYNLDKAASENKVDVMGSLNEMRRQRTTMVQTEGQYIFIYRA
 ...|||||||||.| ..  |  |.|   .   ||   |. .| ||. .|||  |. ..| |
ayllvhcsaGvGrsGvvvlsdvilaklrkkripdvaailsilreqrarlvqtleqfellyda
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 1581-1634 2.3e-10 34.4 In-house 36-89 (440) alignment 
Range on Protein: 1581-1634
Range on HMM: 36-89/440.0
NTRTDAAQQMANKSKNRFQNIMPYDASRVKLSALPGVVGSDYINASYIDGFRQR
 . .| |    || |||..||. || ||| |  . ||  |||||||||.|   |
sqpsdiaslpnnkvknryrnilaydhsrvmleevkgvpdsdyinasyingiesr
subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 1299-1376 3.2e-10 34.1 In-house 35-117 (347) alignment 
Range on Protein: 1299-1376
Range on HMM: 35-117/347.0
DRNRQKNRFANILAYDHSRVPLH-----KLPNDPYSDYINANYIDGYNQPKSYIAAQGPLPHTLMDFWRMIWEQRVSVIVMVT
... .|||  .    | .|| |      . . |.   |||| .|   |  | || .| |||.|. |||.|.   .|. .| . 
ekslsknrskdvklidatrvvlspeksknsraddvetyinashikfdnaskeyiltqyplpdtvrdfwkmvsvtkvtqvvtif
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 1337-1392 4.9e-10 33.3 In-house 229-281 (440) alignment 
Range on Protein: 1337-1392
Range on HMM: 229-281/440.0
IDGYNQPKSYIAAQGPLPHTLMDFWRMIWEQRVSVIVMVTNLEEKgrtKCHRYWPE
..|| . ...||.| ||  |..||||.. . |.| |.|. .|..|    |  ||| 
fegyskknafiatqmpldstvldfwrlvhdyristiimlnqlndk...tcsiywpv
subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 1784-1843 7.4e-10 33.0 In-house 214-273 (301) alignment 
Range on Protein: 1784-1843
Range on HMM: 214-273/301.0
LKPTVVHCSAGVGRTGAYCAAVICLERMKQENKVDLYQVTKHLRTQRPGMVQTAEQYAFV
 || |||||||.||. |. .. .   ... .....| .  |||| .|   ||| .|  ..
ekPivvhcsaGiGrsvafigteylareveadptieltealkhlrehrwngvqtnsqlywm
subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 1646-1762 7.7e-10 33.3 In-house 38-154 (255) alignment 
Range on Protein: 1646-1762
Range on HMM: 38-154/255.0
S-TLADFWRMVWEQEVHSIVMLTHLEESGRQKSEQYWPSLGSDPLNVGDLQVSISEeeHKSFGVERTLTLLNPVS--DQAREVKHWQFPNWPSSGEMGSG
| |.. |....  .. . .|||. ..| |..| ..|.|    . | . |..|. ..    .  | |||...  ..   ....|||...  |.        
sltvdkfyqtivqtktevvvmlcdfaeegvekcssyfplekdeklkladvnvtttk..ssadvvlrtleitstlgekkkthtvkhysykGWieknaPela

RDLVDLVMRVEDYaRSKVVV
|..  ..  | |  .| ||.
reilnilkvvrds.ksvvvh
subfamily_hpo-7_pd Subfamily hpo-7 1645-1758 1.2e-09 32.4 In-house 44-156 (263) alignment 
Range on Protein: 1645-1758
Range on HMM: 44-156/263.0
QSTLADFWRMVWEQEVHSIVMLTHLEESGRQKSEQYWPSLGSDPLNVGDLQVSISEEEHksFGVERTLTLLNPVS--DQAREVKHWQFPNWPSSGEMGSG
  |.. |....  .. . .|||.  .| |..| ..|.|    . . . ...|. ..  .    . .|| ||. ..   . ..|||...  |.   .    
vqtidkfyqtivqtktevvvmLcDfneegvekcssyfPlekdekqklanvnvcttkvqs..dvllktlellstlgeKkkthtvkhysykgWiekndpela

RDLVDLVMRVEDYaRS
|. . ..  . .  .|
reilnilkvarns.ks
subfamily_Cele-PTP-12_pd Subfamily Cele-PTP-12 1589-1677 1.5e-09 31.8 In-house 31-118 (332) alignment 
Range on Protein: 1589-1677
Range on HMM: 31-118/332.0
QMANKSKNRFQNIMPYDASRVKLSALPGvvGSDYINASYIDGFRQRKQFIATQGPMQS-TLADFWRMVWEQEVHSIVMLTHLEESGRQKS
 . |   ||   .  .| |||.|.   |    |. |||..||. ..  .| .| |..  |   ||||| |..   |...  ..|  ..|.
flnnmdmnriphlycfdhsrvelapqdg..kddfynaswvdgyskksayifaqapfndhteyvfwrmvserkpsmilvfgdidekqkrka
subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 1591-1696 2e-09 31.3 In-house 50-153 (302) alignment 
Range on Protein: 1591-1696
Range on HMM: 50-153/302.0
ANKSKNRFQNIMPYDASRVKLSALPgvvgSDYINASYIDGFRQRKQFIATQGPMQSTL---ADFWRMVWEQEVHSIVMLTHLEESGRqKSEQYWPSLGSD
.| .||. ...  .|. .|||.| |     .|.||| ..    ... | .| | ...    ..|||||..... |.|.|   ||  .   ....| .  |
knlkknqsedvpildsnlvkleaep....dsyvnaskvevPeltrsiilaQlpkvdsedsveeFWrmvfqekivsvvilvgeeelkk.tlselfpkksgd

PLNVGDLQV
 .. |.. |
ykeygkmfv
subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 1590-1666 2.6e-09 31.1 In-house 35-116 (347) alignment 
Range on Protein: 1590-1666
Range on HMM: 35-116/347.0
MANKSKNRFQNIMPYDASRVKLSALPGVVG-----SDYINASYIDGFRQRKQFIATQGPMQSTLADFWRMVWEQEVHSIVML
  . |||| ..    ||.|| ||      .       |||||.|     .|..| || |. .|. |||.||    |  .| .
ekslsknrskdvklidatrvvlspeksknsraddvetyinashikfdnaskeyiltqyplpdtvrdfwkmvsvtkvtqvvti
subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 1785-1846 3e-09 31.3 In-house 136-199 (199) alignment 
Range on Protein: 1785-1846
Range on HMM: 136-199/199.0
KPTVVHCSAGVGRTGAYCAAVICLeRMKQENK---VDLYQVTKHLRTQRPGMVQTAEQYAFVYRV
 | .|||| | | || . |  | . | ..| |   |||..|.| ||  | |.. . ..| |.|.|
apvivhcsdgqgftgvfvaldigv.rsheesktsvvdlfevakrlrqarcgiisslqhynfiyqv
subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 1785-1846 3e-09 31.3 In-house 135-198 (198) alignment 
Range on Protein: 1785-1846
Range on HMM: 135-198/198.0
KPTVVHCSAGVGRTGAYCAAVICLeRMKQENK---VDLYQVTKHLRTQRPGMVQTAEQYAFVYRV
 | .|||| | | || . |  | . | ..| |   |||..|.| ||  | |.. . ..| |.|.|
apvivhcsdgqgftgvfvaldigv.rsheesktsvvdlfevakrlrqarcgiisslqhynfiyqv
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 1778-1852 3.2e-09 30.6 In-house 259-345 (349) alignment 
Range on Protein: 1778-1852
Range on HMM: 259-345/349.0
HAILQQLKPTVVHCSAGVGRTGAYCAAVICLE----RMKQENKVDLYQVTK--------HLRTQRPGMVQTAEQYAFVYRVILDYLD
.   .|| . .|||||| |||| ..   . |.      .. ||..| ...|        .|| ||  |||   |. ..|  .| |. 
yldtdqlstllvhcsaGcGrtGvlvtldlllsileplqnesnkiklqallkDlisiivnelrkqrismvqnlaqfiaiyealLkyfa
subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 1785-1850 8.1e-09 29.5 In-house 224-289 (310) alignment 
Range on Protein: 1785-1850
Range on HMM: 224-289/310.0
KPTVVHCSAGVGRTGAYCAAVICLERMKQENKVDLYQVTKHLRTQRPGMVQTAEQYAFVYRVILDY
 | |||||||..|... .|  . ...... .|||. .|  .|. .|   .||  || .. || . .
gpcvvhcsagkdrlyvvvalklkidkldrglkvdaeevktellksraiciqtelqyliidrvriif
subfamily_eak_pd Subfamily eak 1304-1448 1.4e-08 28.5 In-house 55-196 (332) alignment 
Range on Protein: 1304-1448
Range on HMM: 55-196/332.0
KNrFANILAYDHSRVPLHKLPNDPySDYINANYIDGYNQPKSYIAAQGPLPHTLMDFWRMIWEQRVSVIVMVTNLEEKGRTKCHRYWPEEVGGQLPLT--
.|   .|. ||.  | |     ..   ||||  ..  .  . || .  .    .. ||.|. ||.   ||.. .  |..  |  .|.|..   .|     
rn.vvkivpydrylvrltssqlnr.lGyinaslaefsevGrkyiltGiasedkvfafwqmvleqkspaivqlledvelkleksdkyfpdktreelkfGil

-TNMSVFmTKQEefpDMVIRHLTVQVSQQSRVVTQFHYISWPDHGVPD
  .   |  |..    .  | | ...  ..  |  ...  | .  .| 
dverkef.vkrn...iletrllelskGnethrvlhykvfGwtettlpk
subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 1779-1853 1.9e-08 28.3 In-house 204-278 (312) alignment 
Range on Protein: 1779-1853
Range on HMM: 204-278/312.0
AILQQLKPTVVHCSAGVGRTGAYCAAVICLERMKQENKVDLYQVTKHLRTQRPGMVQTAEQYAFVYRVILDYLDK
|. .. || . ||||||||||. .     .  ...  | .. ..   || .|   |..  || .. |..|..|  
avkkdkkpviahcsagvgrtgtlaliesmiaalrhprkqnvkdsfvllrkdrarsvrvfpqyvyalrcvleflys
0038934 (Phosphotyrosine protein) phosphatases II 1741-1846 2.5e-08 29.3 In-house 71-172 (194) alignment 
Range on Protein: 1741-1846
Range on HMM: 71-172/194.0
SGRDLVDLVMRVEDYARS-KVVVPQEESIYGNREAINEHAILQQLKPTVVHCSAGVGRTGAYCAAVIclerMKQeNKVDLYQVTKHLRTQRPGMVQTAEQ
. ... .. ... ..    . .||. | ..   ....|.   .. .  .||| ||.||||  .|| .    ..  .. .. .  ...|  |||.... ..
dpeefekagieylklpfpddgtvPsleillrfldlvdeflnedpggvvaVHCkaGlgRtGtlvaaYL....iyr.lgmsaeeAialfrekRpgaipnqdy

YAFVYRV
.  ... 
leallkr
subfamily_egg_pd Subfamily egg 1782-1852 2.7e-08 27.9 In-house 199-271 (307) alignment 
Range on Protein: 1782-1852
Range on HMM: 199-271/307.0
QQLKPTVVHCSAGVGRTGAYCAAVICLERMKQ--ENKVDLYQVTKHLRTQRPGMVQTAEQYAFVYRVILDYLD
.  ||.||..  || ....  |. | |  . .    |  . .  . || .|.  |... .| ||||..| .. 
nlskpvvvqdilGvskaatlvaieiallsllrGpitkslvlravvflrlrrrlsvesvllylfvyrlvlfffr
subfamily_Cele-PTP-5_pd Subfamily Cele-PTP-5 1789-1857 2.7e-08 26.8 In-house 247-315 (346) alignment 
Range on Protein: 1789-1857
Range on HMM: 247-315/346.0
VHCSAGVGRTGAYCAAVICLERMKQENKVDLYQVTKHLRTQRPGMVQTAEQYAFVYRVILDYLDKQNGA
|    | ||. ..  |.  .... .  . ..... | .. |||| |..  ||| .| ...||. .. | 
vvslfgcgracsfigalyainqlnngiepniceimknikqqrpggvesfaqyasiyaivfdyiarkrgg
subfamily_hpo-7_pd Subfamily hpo-7 1772-1862 3.6e-08 27.6 In-house 142-238 (263) alignment 
Range on Protein: 1772-1862
Range on HMM: 142-238/263.0
REAINEHAILQQLKPTVVHCSAGVGRTGAYCAAVICLE----RMKQENK--VDLYQVTKHLRTQRPGMVQTAEQYAFVYRVILDYLDKQNGAGPMAA
|| .|   . ...|. |||||.|.||. |.  | .        ... .   .|  .. ..|| .|.. ..|  | ||   ..||.. ...  | . |
reilnilkvarnskslvvhcstGiGrsaafsvaElvyqkmirsldttstveldylsLleelrssrkraihtPmqLafsilmvLdfvlnnfakgelea
PTEN_1 1435-1488 3.8e-08 28.4 In-house 96-149 (196) alignment 
Range on Protein: 1435-1488
Range on HMM: 96-149/196.0
QFHYISWPDHGVPDsTAGILTTIRRAKETRNQAA-AGPMVVHCSAGVGRTGTLIA
... ....|||.|.  . ..  .....| . ..   .  .||| ||.||.||..|
eylhfpieDhgaps.lselfdicksfiewllsdpngnvVlVHCkaGlgRsGtvva
subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 1783-1869 3.9e-08 27.8 In-house 190-266 (290) alignment 
Range on Protein: 1783-1869
Range on HMM: 190-266/290.0
QLKPTVVHCSAGVGRTGAYCAAVICLERMK-QENKVDLYQVTKHLRTQRPGMVQTAEQYAFVYRVILdyldkqngagpMAAMESMYAT
.  | .|||  |. |  |  |  .    .  ....| | .| | || ||  ....|...|||  .|.           . |.| . ..
sktpvivHcvdGiSrsAalaaiilgyQkiaetsgsvkledvlkalrkqralaitsalelafvdagiv...........llaievldqf
subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 1772-1869 4.4e-08 27.5 In-house 136-233 (255) alignment 
Range on Protein: 1772-1869
Range on HMM: 136-233/255.0
REAINEHAILQQLKPTVVHCSAGVGRTGAYCAAVICLE----RMKQEN--KVDLYQVTKHLRTQRPGMVQTAEQYAFVYRVILDYLdkqngaGPMAAMES
||  |   . .. |. |||||.|.||. |.  | .        ... .  ..|  .. ..|| .|.. ..|  | ||   ..||..       | ...| 
reilnilkvvrdsksvvvhCstGiGrsaafvlaelvyqkmirsldttetveldylslleelrskrkraihtPlqlafsilmvldlv......fpkgelea

MYAT
 |  
kyqe
subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 1787-1847 4.7e-08 26.8 In-house 224-284 (302) alignment 
Range on Protein: 1787-1847
Range on HMM: 224-284/302.0
TVVHCSAGVGRTGAYCAAVICLERMKQENKVDLYQVTKHLRTQRPGMVQTAEQYAFVYRVI
 .|||||||||||.  |    ..  ....  || .. . .|. | | ||...|  ..  ..
vlvhcsaGvGrtGtlvaikyGiqlcskkkvtdllsivlpvrqcryGavqdeqqliylllcv
fn3 Fibronectin type III domain 257-344 7e-08 25.7 Pfam-A 11-78 (85) alignment 
Range on Protein: 257-344
Range on HMM: 11-78/85.0
ATFNSLTVSWAAPPaaAHNTNNLRYRLEYVAKSTTTyadstsvtaaslgisddfsaPMVQTNLVGTQ--TTLTGLHPGLDYVVRLYAHPA
 | .|||.|| .|.    . .  .|..||  |...                     . .. .. .|.   ||||| || .|..|..|. .
vtstsltlsWsppk..dgggpitgYeveyrekggge....................ewkeftvprtttsvtltgLkpgteYefrVqavng
subfamily_PTPDC1_pd Subfamily PTPDC1 1435-1525 7e-08 27.1 In-house 84-165 (182) alignment 
Range on Protein: 1435-1525
Range on HMM: 84-165/182.0
QFHYISWPDHGVPdSTAGILTTIRRAKETrnqAAAGPMVVHCSAGVGRTGTLIAIDYNLDkaaseNKVDVMGSLNEMRRQRTTMVQTEGQY
 .. ..|.|.||. |   ||. .. .. .      | . ||| || |||| |||           ....   ... .| .|.  .|| .| 
yvynfgwkDygva.sleriLdivkvvafa...lqegkvavhChaGlGrtGvliacylvya.....krltaekaiklvrskrpksiqtreqv
subfamily_Cele-PTP-5_pd Subfamily Cele-PTP-5 1357-1534 3.3e-07 23.2 In-house 131-307 (346) alignment 
Range on Protein: 1357-1534
Range on HMM: 131-307/346.0
LMDFWRMIWEQRVSVIV-MVTnlEEKGRTKCHRYWPEEVGGQlPLTTNMSVFMTKQEEFPDMVIRHLTVQVSQQ-SRVVTQ-FHYISWPDHGVPDSTAGI
. ||| ||..... ..  ||   ..| .      . .| ||    | .| .   . .   |     . |    .   |. |  |.  |     |  |  |
vedfwymiyqeqihlvylmvp..ddklkntttslfndenggy.qytgkmfinnrradvsgdpkeytievlpegnsdsvicqvhhhapwkhlqqppktlpi

LTTIRRAKETRNQAAAGPMVVhCSAGVGRTGTLIAIDYNLDKAASENKVDVMGSLNEMRRQRTTMVQTEGQYIFIYRALAD
.  | . .  ..  .||  ||    | ||. ..|   | ...     . ...  . ....||   |..  ||  ||  . |
ikmihqflsekqvqnagvcvv.slfgcgracsfigalyainqlnngiepniceimknikqqrpggvesfaqyasiyaivfd
subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 1286-1340 4.1e-07 23.8 In-house 24-77 (244) alignment 
Range on Protein: 1286-1340
Range on HMM: 24-77/244.0
ESGSEFGRNYAIMDRNRQKNRFANILAYDHSRVPLHKLpNDPYSDYINANYIDGY
.   || .  |..  |  |||. ||| .|..|| |    .   |||||||||.| 
dhtreflqtnavlsanatknryinilpfdetrvilsss.kkegsdyinanyiqgs
Adeno_E3_CR2 Adenovirus E3 region protein CR2 1132-1159 1.4e-06 17.0 Pfam-A 7-34 (38) alignment 
Range on Protein: 1132-1159
Range on HMM: 7-34/38.0
GIIVGVVIVIIVLIVAVLVFVMWRRRQN
.|||.||......|   |...  .|.  
aIivaVvvGlaiIiicmlyYaCcYrkhr
subfamily_ptpA1_pd Subfamily ptpA1 1817-1851 1.4e-06 22.4 In-house 364-398 (418) alignment 
Range on Protein: 1817-1851
Range on HMM: 364-398/418.0
VDLYQVTKHLRTQRPGMVQTAEQYAFVYRVILDYL
..|. .  .|| |||||||  ||| |.|. ||| .
fnlfsivlklreqrpgmvqqleqylfcyktildei
subfamily_PTPDC1_pd Subfamily PTPDC1 1786-1843 1.9e-06 22.4 In-house 116-168 (182) alignment 
Range on Protein: 1786-1843
Range on HMM: 116-168/182.0
PTVVHCSAGVGRTGAYCAAVICL-ERMKQEnkvdlyQVTKHLRTQRPGMVQTAEQYAFV
 . ||| || ||||   |. .   .|.. |      .  | .| .||  .|| ||  .|
kvavhChaGlGrtGvliacylvyakrltae......kaiklvrskrpksiqtreqvelv
subfamily_DSP23_pd Subfamily DSP23 1419-1526 2.8e-06 22.1 In-house 32-136 (148) alignment 
Range on Protein: 1419-1526
Range on HMM: 32-136/148.0
IRHLTVQVSQQSRVVTQFHYISWPDHGVPDSTAGILTTI----RRAKETRNQAAAgpMVVHCSAGVGRTGTLIAIDYnldkaASENKVDVMGSLNEMRRQ
.|.|     .    |     ...   ...| .   |  .    |  .|. ... |  . |||  | |||||..|  .       |.|.    .. |.||.
vrylvslteegrphveatpnltlvrlriddyhppaleqvvefvrvveeaeeknea..vsvhcllgrgrtgtmlacyl.....vkerklaaaeaiaevrrl

RTTMVQTEGQYI
|   |.|  |  
rpgsvetveqek
Shisa Wnt and FGF inhibitory regulator 1107-1201 4e-06 16.0 Pfam-A 50-148 (179) alignment 
Range on Protein: 1107-1201
Range on HMM: 50-148/179.0
ELCQAASLNPTT--ALASTAAAPA-D-NTGIIVGVVIVIIVLIVAVLVFVMWRRRQNKAAAPDEDFWRNDTASTMTNSTAVDVNNFHSPVPAPRSGPSM
. |.    .  |   ...    |  |  . .||........ .|....|.     ..||  . ..   . ...|...      .. .   |.|.|  ..
stCknedesvstdgkfrkpvedptkdlkvvlivsiilivvfivvliviftcskcvlekavrrqrpvvtsassttvqatplpqeeskapsypqpqsqgye
PTEN_1 1783-1844 7.6e-06 20.9 In-house 129-186 (196) alignment 
Range on Protein: 1783-1844
Range on HMM: 129-186/196.0
QLKPTVVHCSAGVGRTGAYCAAVIclerMKQENkVDLYQVTKHLRTQR-PGMVQTAEQYAFVY
. .  .||| ||.||.|  .||      |. ..  .  .  ...| .| ||......| ....
ngnvVlVHCkaGlgRsGtvvaayL....mykgk.ltadeAlelvrekRppgapnspsqerlle
subfamily_Sponge-PTP-2_pd Subfamily Sponge-PTP-2 1587-1671 9e-06 18.7 In-house 22-79 (169) alignment 
Range on Protein: 1587-1671
Range on HMM: 22-79/169.0
AQQMANKSKNRFQNIMPYDASRVKLSALPGVVGSDYINAsyidgfrqrkqfiatqgpmqstladfwRMVWEQEVHSIVMLTHLEE
|.  .|..|||    .     ||||  .   .|||||||                           ||.|| .   ||.|   ..
aeltcnetknrpagplapshtrvklqrvmedlgsdyina...........................rmiwetnasvivvlgdtdd
subfamily_CDC14_pd Subfamily CDC14 1467-1489 9.3e-06 19.7 In-house 261-283 (328) alignment 
Range on Protein: 1467-1489
Range on HMM: 261-283/328.0
AAAGPMVVHCSAGVGRTGTLIAI
 | | ..||| ||.|||||||| 
kaeGaiavhCkaGLGrtGtLiac