Gene FIG4 in Monosiga brevicollis

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family Sac
Subfamily FIG4
Protein sequence
ID Type Fasta BLAST phosphatome Note
MbreP070_AA protein Get Run
MbreP070_AA_134-471 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_FIG4_pd Subfamily FIG4 6-495 3.4e-228 749.6 In-house 76-562 (569) alignment 
Range on Protein: 6-495
Range on HMM: 76-562/569.0
FQSFLKGYYLIVVTKRKQVASIGAHAIYRVEDTIMISLFSKSVAGPDLPEEERYRRIFHNVDLTSNFYFSHTYDLTRPVQSNMYLPSDLERQRLAEPKP-
|  ||.|||||.|||||.||.||.||||..||. .|.. ..|.  .. ..|.||...|..||||.|||||..|||||..|.|..|... .... ||..  
fvrflegyylilvtkrkkvaviGghaiykiedialikitedskksekssdearylklfkdvdltknfyfsysydltrtlqtnlllsdsnrekekaedrvd

-----PVLKPDETFLWNHFLLHPFHDTLRP-EWLISLTHGFVSQSDINIYGRHIYVTLIARRSRHYAGTRFLKRGCDNAGHCANHVESEQIVHDASEISH
      .|. .|.|.||.|||.|..||... .||....|||||||.|...|..||||||||||...||.||||||..|.|..||.||.|||||.|||.|.
itieakkldanekfvWnnflleplkdtvktfdWlleiihGfvsqskisvlgksiyvtliarrsskfaGarflkrGvnnkGdvaneveteqivheasegsl

RRAFITSYIQMRGSVPVHWEQDHAGMKAKPPISIARADPFASAAAMHFERLFHKFGAPIIAFDLVKKKERRPRESILLNAYTAALGYLNKFLPKESAIQH
... ..|..|.|||||..|.||.. ...||||.|...||||||||.||..||...|.||| ..||||||.|.||||||....||. |||.|||.|.....
dsdryssfvqlrGsvPlyWsqdasklvtkPpikidvvdPfasaaalhfddlfqryGspiiilnlvkkkekrkresilleefeaaieylneflPeekklky

VSWDMAKSNKSREPVVLRILDQYAQHFLKQQGIFTSRQRLSLVAeadagldSGHGVVRVNCVDCLDRTNTAQFMIGLCALRHQLFELGVIADtqaSQIPP
.|||||...||.|  ||..|..||....|..|||.|...|. ..       . .|.||.||||||||||.|||.|| .||..||..||.|..   |..  
iswdmaraskskeenvlevlekyaeksvkktGiflsapdlestk.......iqeGivrtnCvdcldrtnaaqfvigkvalgyqlkslGiide...sklef

DSPVNRVLEEMYEDHGDTIALQYGGSQLVNRIQSYRKTRPWTSNSRDILNTVARYYSNSFTDADKQMAINLFLGKYVPLKEDEPLWLQYSDYFLHYP
|| |.|.|||.|||.|||.|||||||||||.|..|||...|.|.|||||.|..|||||||.|||||.|||||||.|.| .. ..||   .|. ||. 
dsdvvrlleelyedlGdtlalqygGsqlvntiktyrkiaqwssksrdiletlkryysnsfvdadkqdainlflGvyspreglpslWeletdfylhna
Sac_COG5329 8-476 5.6e-104 340.2 In-house 69-521 (1070) alignment 
Range on Protein: 8-476
Range on HMM: 69-521/1070.0
SFLKGYYLIVVTKRKQV-ASIGAHAIYRVEDTIMISLFSKSVAGPDL-PEEERYRR--------IFHNVDLTSNFYFSHTYDLTRPVQSNMYlpsdlerq
 . . ..|||.|. ..| . |. ..||....  .|||  ..    .  ..| ...         ..  .. .. |||| ..|.|  .|.. .        
elegslflivitgkskvaqvipgetiykilavdfislnnnkwddeeiesdeasteklrsehpcselkkLlsngsFYfStdfditntLqkrlk........

rlAEPKPPVLKPDETFLWNHFLLHPF------HDTLRP------EWLISLTHGFVSQSDINIYGRHIYVTLIARRSRHYAGTRFLKRGCDNAGHCANHVE
   |... | . || |.||.|||  .      ...|        ..|  . .||... .|.. .. |. |||.||| . ||||||.|| |. |..|| ||
..eelelsvdtadeefmwnsflleelinyrsklsslekqlldnagFlttvIrGFaetvfikvkkktiaLtlISRrSskragtRflarGvDddGnvanFVE

SEQIVHDAseishrrAFITSYIQMRGSVPVHWEQDhAGMKAKPPISIARADP-FASAAAMHFERLFHKFGApIIAFDLVKKKErrpRESILLNAYTAALG
 |||| ..        ...|..|.|||.|. |||.  .   .|.|.|.| .. . ||.. ||..|| | |  .   .|.|.|.   .|  |. .|   | 
TEqIvyss.......qycfsFtQvRGSiPiFWeqe.snsligpkiqitrsseatqsafdkHFdklfekYGd.vhivNLlktKs...sEieLseryekhlk

yLNKFLPKesaiQHVSWDMAKSNKSREPVVLRILDQYAQHFLKQQGIFTSrqrlslVAEADAGLDSGHGVVRVNCVDCLDRTNTAQFMIGLCALRHQLFE
 |.....     . ...|. |  .  .. ... | ....  |...| |.         . .. .   .||.|.|| |||||||..|..|.. .|  |.. 
.lsekpki....hlteFdfhketsqdgfddvkkLlplieqdllefgyfsy......dvkegkliseQdGVfRtNClDCLDRTNviQqliskrvlleqfrs

LGVIADTQASqippdsPVNRVLEEMYEDHGDTIALQYGGSQLVNRIQSYRKTRPWTSNSRDILNTVARYYSNSFTDADKQMAINLFLGKYVP
..||.....       .    |.|.. |.||.|. .|.|.. ...  .....| . . ..|... | |.|.|.|.|. || ||.|.|||. .
ikvisaidde......dflqklneLWadnGDaisqiYTGtgalkssftrkgkrsiagalsDatkSvsRmyinnfvDkekQdaidllLgklpd
subfamily_SAC1_pd Subfamily SAC1 9-476 4.8e-88 286.8 In-house 16-455 (458) alignment 
Range on Protein: 9-476
Range on HMM: 16-455/458.0
FLKGYYLIVVTKRKQVASIGAHAIYRVEDTIMISLFSKSVAGP--DLPEEERYRRIFHNVDLTSNFYFSHTYDLTRPVQSNMYLPSDLerqrlAEPKPPV
 |.| ||||.||...|..| .. ||||.|. .|.. ..|.     .  ||..| .. ..|  ...|||| |||||...| .    |        . .. .
LlsgkylivitkkeevgringkviyrvadveiipvkknslslteeqkkeekeylkllelvlksetfYfsytydltnslqrlekvtsaa.....lkersll

LKPDETFLWNHFLLHPF-HDTLRPEWLISLTHGFVSQSDINIYGRHIYVTLIARRSRHYAGTRFLKRGCDNAGHCANHVESEQIVHDAseishrrAFITS
 . || |.||. ||. . ..    .... ...||........ ...|  .||.||| . ||||. .|| |. |..||.||.||||.           .||
eradeRffwnkhlledlrkepelesfilPvikGfikikelslnakeikfilisRRsifRaGtRyfvRGvdkeGnvanfvEtEqiveae.......kalts

YIQMRGSVPVHWEQDhAGMKAKPPISIARADPFASAAAMHFERLFHKFGAPIIaFDLVKKKErrpRESILLNAYTAALGYLNkflpkESAIQHVSWDMAK
..|.|||.|..|.|    .| || ... . .   .|   |.... ...|  ..  .|| .|    .|  | .||   .  ||     .. |..|..|  |
FvqvRGsiPllWsqk.pnLkykPkvklsesedsldafkkhldeqielygenvl.vnLvdqkG...sEkklgeayesvvraln.....kkkikyvafDFHk

SNKSREPVVLRILDQYAQHFLKQQGIFTSrqrlslvAEADAGLDSGHGVVRVNCVDCLDRTNTAQFMIGLCALRHQLFELGVIADTQASQIPpdSPVNRV
  ..     | .| .  .. |.|.|.|.         |..    . .|||| ||.|||||||  | ...  .|..|| .|||.|  .. .    ......
eCrkmrwdrlklLidqlekelsqegyflk.......seekkivkeqkgvvRtnCiDcLDRtnvvqsllarevLqkqleslgvlateskleds..aelets

LEEMYEDHGDTIALQYGGSQLVNRIQSYRKTRPWTSNSRDILNTVARYYSNSFTDADKQMAINLFLGKYVP
  ... |..|... || | .           |  .   ||..|.| ||| | |.|  .| .|.||||||..
fknlwadnadavsvqYaGtgAlKtDftRtGkrtllGalrDgvnsvsryyknnfldgerqdsidLflgkyrv
Syja_N SacI homology domain 8-308 8.2e-83 269.1 Pfam-A 9-313 (319) alignment 
Range on Protein: 8-308
Range on HMM: 9-313/319.0
SFLKGYYLIVVTKRKQVASIG-AHAIYRVEDTIMISLFSKSVAGP--------DLPEEERYRRIFHNVDLTSNFYFSHTYDLTRPVQSNMYLPSDLERqR
..|...||.|.|||..||.|.  | ||..... .|.| |.. .          . .|||.. . ..... ...||||..||||| .|...   .. .. .
rllsesyllvitkrekvakirgehpiykiksvefiplnseeeessaieeekeeeekeeekllkllkkllssgsfYfSydyDltrslqrksekeeeeke.e

LAEPKPPVLKPDETFLWNHFLLHPFHDTL--RPEWLISLTHGFVSQSDINIY-GRHIYVTLIARRSRHYAGTRFLKRGCDNAGHCANHVESEQIVHDase
 .. .| . ..|| |.||..||.|. .      .||. | .|||.|. |..  ......|||.|||...||||.|.||.|. |..||.||.||||..   
eskslpllkevderFvWNrnllkplielkldlsrwllpliqGfveqrsievkskkkveltLIsRrsvkraGtRylrRGidddGnvANfvEtEqivse...

ISHRRAFITSYIQMRGSVPVHWEQdHAGMKAKPPISIA-RADPFASAAAMHFERLFHKFgAPIIAFDLVkkkERRPRESILLNAYTAALGYLNKFLPKES
 ....  ..|..|.|||||..|||   ... ||.|.|    ..  .|.. ||..|....  .|.. .|.   |...||. | .||.... .|||.|....
kkeeskrvfSfvqiRGSvPlfWeq.asnlslkpkikitrsseasqkafkkHfkklikrY.gkivvvnLl...ekkgrEkkLseayeelinklnkklkekk

AIQHVSWDMAKSNK
 ......|. |. |
klkyiefDfhkeck
Syja_N SacI homology domain 8-308 8.2e-83 269.1 In-house 9-313 (319) alignment 
Range on Protein: 8-308
Range on HMM: 9-313/319.0
SFLKGYYLIVVTKRKQVASIG-AHAIYRVEDTIMISLFSKSVAGP--------DLPEEERYRRIFHNVDLTSNFYFSHTYDLTRPVQSNMYLPSDLERqR
..|...||.|.|||..||.|.  | ||..... .|.| |.. .          . .|||.. . ..... ...||||..||||| .|...   .. .. .
rllsesyllvitkrekvakirgehpiykiksvefiplnseeeessaieeekeeeekeeekllkllkkllssgsfYfSydyDltrslqrksekeeeeke.e

LAEPKPPVLKPDETFLWNHFLLHPFHDTL--RPEWLISLTHGFVSQSDINIY-GRHIYVTLIARRSRHYAGTRFLKRGCDNAGHCANHVESEQIVHDase
 .. .| . ..|| |.||..||.|. .      .||. | .|||.|. |..  ......|||.|||...||||.|.||.|. |..||.||.||||..   
eskslpllkevderFvWNrnllkplielkldlsrwllpliqGfveqrsievkskkkveltLIsRrsvkraGtRylrRGidddGnvANfvEtEqivse...

ISHRRAFITSYIQMRGSVPVHWEQdHAGMKAKPPISIA-RADPFASAAAMHFERLFHKFgAPIIAFDLVkkkERRPRESILLNAYTAALGYLNKFLPKES
 ....  ..|..|.|||||..|||   ... ||.|.|    ..  .|.. ||..|....  .|.. .|.   |...||. | .||.... .|||.|....
kkeeskrvfSfvqiRGSvPlfWeq.asnlslkpkikitrsseasqkafkkHfkklikrY.gkivvvnLl...ekkgrEkkLseayeelinklnkklkekk

AIQHVSWDMAKSNK
 ......|. |. |
klkyiefDfhkeck
subfamily_INPP5F_pd Subfamily INPP5F 70-474 1.3e-73 239.6 In-house 136-506 (951) alignment 
Range on Protein: 70-474
Range on HMM: 136-506/951.0
SNFYFSHTYDLTRPVQSNMYLPSDLERQRLaepkppvlkpDETFLWNHFLLHPFHDTLRPE---WLISLTHGFVSQSDINIYGRHIYVTLIARRSRHYAG
 .||.| ..|||. .|.... . .   .            || |.||.|||... ..   .   .|. .  |||. . |.|   .. .||| ||||. ||
gsFYysldfDltntlqkrgleeksestddw..........derFfWNkfllkdlinyrdkldkefltpviqGfvetkeisieklkvsltlisrrSrkrag

TRFLKRGCDNAGHCANHVESEQIVHdaseishRRAFITSYIQMRGSVPVHWEQDhaGMKAKPPISIARADPFASA-AAMHFERLFHKFGApIIAFDLVKK
||| .|| |. |..|| ||.|.|..        . .. |..|.|||||| |||.  |.| ||.| |.| .  . .    ||.....|.|  .    |...
trfkrrGidddgnvAnfvEtElils.......vekyvlsftqirGSvPvfweqs..gkkykpkikitrseeetqpaFdehfkeqlkkygk.vvivnllsq

KErrpRESILLNAYTAALGYLNkflpkESAIQHVSWDMAKSNKSREPVVLRILDQYAQHFLKQQGIFTSRQRLSLVAEAdagldsgHGVVRVNCVDCLDR
|.   .|..| .||  .|  |.     .. .  .. |. . ... .   .. | .. .  .|. | |   ..  ...|        .||.|.||.|||||
ks...sekklskaykeqllkle.....skdvflikfdfheetsgekfenvsklielikneikevgyfsydvkekviseq.......kgvfRtnclDcldr

TNTAQFMIGLCALRHQLFELGVIADTQAsqiPPDSPVNRVLEEMYEDHGDTIALQYGGSQLVNRiqSY-RK-TRPWTSNSRDILNTVARYYSNSFTDADK
||..| .|.. .|. || .||..  ..     .|. ... |.... |.||.|  || |.. .    .. ||  |  .    |  ..| ||| | | |. .
tNvvqqaiskavlelqleklglfepess...iddeellqklkklWadngdaisrqYagtnalkg..dltrkgerklaGvlkdgyksvsryylnnfkdkyr

QMAINLFLGKY
| .|.| ||| 
qkvidlllGkl
subfamily_Synaptojanin_pd Subfamily Synaptojanin 14-475 4.7e-56 181.6 In-house 24-438 (754) alignment 
Range on Protein: 14-475
Range on HMM: 24-438/754.0
YLIVVTKRKQVASIGAHAIYRVEDTIMISLFSKSVAGpdlpeeERYRRiFHNVDLTSNFYFSHTYDLTRpvqsnmylpsDLERQRLAEPKPPVLKPDETF
.|..||  |.|  |    |... .| ..|| |..         .|.    ...  . .||||.. | ..           |. .. |. .    . |. |
flvlvtgcksvGkisdaeifkitstelvslrseasde......driie.lkkllasgtfyfsssadsas..........rldlslsaqrrkqeesednrf

LWNHFLLHPF--HDTLRPEWLISLTHGFVSQSDINIYGRHIYVTLIARRSRHYAGTRFLKRGCDNAGHCANHVESEQIVHDASEishrrafITSYIQMRG
.||. |   .  ..    .||...  | |.   . .  . . ..||.| |   |||||  || .. |. || || ||..    .       .||..|.||
fWnrslhlhlqrfgvncddWllkvmcGsveirtvyagakqakaalisrlsceraGtrfnvrGvndeGnvanfveteqvillddk.......vtsfvqirG

SVPVHWEQDHAGMKaKPPISIARADPFAS-AAAMHFERLFHKFGAPIIaFDLVKKKErrpRESILLNAYTAALGylnkFLPKESAIQHVSWDMAKSNK-S
|||. |||    .  .  . ..|.   .. |   |.| | ...|  .|  .|. .||    |..| .|.   |         ......|..|. .. | .
svPlfWeqPGlqvG.shkvklsrgfeasaaafdrhleqlkeryGevvi.vnllGske...geevlskafkkhlk....asehakdvpfvkfdyhqkvkgg

REPVVLRILDQYAQHFLKQQGIFTSRQRLslVAeadaglDSGHGVVRVNCVDCLDRTNTAQFMIGLCALRHQLFELGviADTQASQIppdSPVNRVLEEM
.. .. ..|.. ...||.....|.|...   |        . .||.||||.|||||||. | ..||  | .||  |.   ....|..   | ...|....
kkeklekllkkqlklflesasfflskgke..ve......keqtGvlrvnClDCldrtnavqtvlglevlekqlealk..lsskesvv...srfeevfksl

YEDHGDTIALQYGGSQLVNriqSyrKTRpwTSNSRDILNTVARYYSNSFTDADKQMAINLFL-G-KYV
..  || |.  | |.. ..   .  |..  .|  .|   .|||   | | |. || ||.|.| |  ||
WsknGdeiskiyaGtgale...g..kak..vsklkdgarsvartiqnnfldsskqeaidllllgntyv