Gene LHPP-1 in Monosiga brevicollis

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold HAD
Superfamily HAD
Family NagD
Subfamily LHPP
Protein sequence
ID Type Fasta BLAST phosphatome Note
MbreP079_AA protein Get Run
MbreP079_AA_1-227 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_LHPP_pd Subfamily LHPP 6-225 4.9e-89 289.1 In-house 1-222 (227) alignment 
Range on Protein: 6-225
Range on HMM: 1-222/227.0
VFVDISGTLLVGNAALPGAIDALARLKQNY-TVRLVTNTSKESQRAIYERLTTLGFAVEPSEVFTSLAATRALLLRDQRRCFFIIPPATEEDFADVPRDS
|..|.||.| ...||.|||..||.||.|.. .||.||||.|||.||..|||..|||.|| .|.||||.|.|.|| ... |..... ...||||.|. .|.
vllDlsGvlhnedaaipgavealkrLrqagvkvrfvtNttkeskralverLirlgfdveeeeiftsleaarqllrerklrpyllveddveedfedidtdk

PDTVVLGLAPDSFDYATLDTGFQILRQ-PDARLIAINTSRFYATPSGVHIAAGAFVRALEYAANVSAHVVGKPSAEFFRAAAASCHLDVESCVMIGDDTG
|..||.||||.||.|.||...|..| . ..|.|||||....|....|.....||||.|||||..|.|.|||||||.||..| .....|.|..||||||. 
pnavviglapesfeyetlnqafrllleakkakliainkgkyykrkdGlalgpGafvkaleyatgvkaevvGKPsalffekaleelgvdpeeavmiGDdve

DDFEGAMRAGLRAMLVATGRFD
||.|||..||||..|| ||.| 
dDveGAlkaGlrgvlVktGkfr
Chronophin_1 5-223 1.1e-36 117.7 In-house 3-230 (261) alignment 
Range on Protein: 5-223
Range on HMM: 3-230/261.0
AVFVDISGTLLVGNAALPGAIDALARLKQN-YTVRLVTNTSKESQRAIYERLTTLGFA-VEPSEVFTSLAATRALLLR--DQRRCFFIIPP-----ATEE
 | .|. | |  |..|.||| .....|||.  .|  ||| |.. .. . .||. ||.. |.  |.|.| .|..||| .   . . . .         .|.
lvLlDldGVlikgeeavpgAaeliealkqagkevlfvtNnsrrtreelaarlkrlGldavaaeeifssalaaaallrqqaakakvyvlGeeglrkelrea

D--FADVPRDSPDTVVLGLAPdSFDYATLDTGFQILRQPdARLIAINTSRFYATPSGVHIAAGAFVRALEYAANVSAHVVGKPSAEFFRAAAASCHLDVE
    .| | |... ||.|  . ..... | .  . .|.. |...| |  .   ...|.  ..|. ..|.| |..  ..|||||..  |..|. .  .| |
GlrlvdepedrveaVvvGyde.elsfeklaeaialirdg.alfvatnrDptvPleeGiaPgtGslaaaveaAsgreplvvGKPepvmfeealekigadpe

SCVMIGDDTGDDFEGAMRAGLRAMLVATGR
. ||.||    | . . ||||...|| || 
etvmvGDRldTDilagaraglstllvltGv
subfamily_PGP_pd Subfamily PGP 105-223 1.5e-18 58.1 In-house 130-248 (279) alignment 
Range on Protein: 105-223
Range on HMM: 130-248/279.0
PDTVVLGLApDSFDYATLDTGFQILRQPDARLIAINTSRFYATPSGVHI-AAGAFVRALEYAANVSAHVVGKPSAEFFRAAAASCHLDVESCVMIGDDTG
 . || |.  . ..|| |    ..||.|.. ..| |. ...  ...| |  ||..|.|.| |.. .. |.|||. . . .   . ..| | ..|||| . 
vgAVvvgvd.eklsyakllkAanyLrepevlflatneDallplkkevvipgaGslvaaieaasgrkplvlGKPnelllelllekeeidpertlmiGDrlk

DDFEGAMRAGLRAMLVATGR
 |   . . ||...|| .| 
tDilfgkncGlqtLlvlsGv
Hydrolase_6 Haloacid dehalogenase-like hydrolase 6-97 5.3e-18 56.3 Pfam-A 1-95 (101) alignment 
Range on Protein: 6-97
Range on HMM: 1-95/101.0
VFVDISGTLLVGNAALPGAIDALARLKQN-YTVRLVTNTSKESQRAIYERLTTLGFAVEPSEVFTSLAATRALLLR--DQRRCFFIIPPATEEDF
...|. |.|. |. |.||| .|| .|... ..| |.|| |..|.... ..|. ||..|....|.||  |....| .   ......|   . .| .
flfDvdGvLwrgdkaipgaaealkalraagkpvvllTNnsskseeeyakkleklgvdvteeqvvtsataaaeylkkrkadkkvlvigeeglreel
Hydrolase_like HAD-hyrolase-like 173-226 1.6e-15 48.1 Pfam-A 2-55 (75) alignment 
Range on Protein: 173-226
Range on HMM: 2-55/75.0
VGKPSAEFFRAAAASCHLDVESCVMIGDDTGDDFEGAMRAGLRAMLVATGRFDA
 |||.......|.. .... ...|||||.  .| |.| .||.|. ||.|| ...
lgKPnpgmydkalevlgappsevvmiGDslatDieaAnnaGirsilVltGvsre
Chronophin_2 107-222 4.2e-13 40.2 In-house 127-243 (282) alignment 
Range on Protein: 107-222
Range on HMM: 127-243/282.0
TVVLGLAPDSFDYATLDTGFQILRQPDARLIAINTSRFYATPSGVHI-AAGAFVRALEYAANVSAHVVGKPSAEFFRAAAASCHLDVESCVMIGDDTGDD
  ||    ... .  |      ||..|  |.| ..  ..   .|  .  .|..  ||| |..  | |.||||  .|   .    .|   ..||||    |
ravlvgydekltflklakacaylrdadclllatdrdpwhplsdgritpgsgsltaaletasgrkatvigkpsrfmfecissqfsvdparslmigdrletd

FEGAMRAGLRAMLVATG
.    . || ..|  ||
ilfgsncglstvltltg
subfamily_PGP_pd Subfamily PGP 6-81 2.7e-11 34.3 In-house 2-79 (279) alignment 
Range on Protein: 6-81
Range on HMM: 2-79/279.0
VFVDISGTLLVGNAALPGAIDALARLKQ-NYTVRLVTNTSKESQRAIYERLTTLGFA-VEPSEVFTSLAATRALLLRD
|..|. |.|  |. |.|||..||..||. .  | .||| | .|.. . .... |||  |. .|...| ||. . | ..
vlfDcDGVlWlgetaipgaaealnaLkklgKkvlfvtNnstksreellkkfkklgfekvkeeeilssaaaiadyLkqk
Chronophin_2 5-83 2.8e-08 24.4 In-house 2-81 (282) alignment 
Range on Protein: 5-83
Range on HMM: 2-81/282.0
AVFVDISGTLLVGNAALPGAIDALARLKQN-YTVRLVTNTSKESQRAIYERLTTLGFAVEPSEVFTSLAATRALLLRDQR
.|. |  | .  |. |..|| . . ||..    | .||| |. ..  . .... ||||    | . | |   |..|||  
nvlfdcdgviwngekavagapevvsrlaragknvlfvtnnstrarenyvlkfarlgfadvaaeqifssaycsaaylrdva
Hydrolase haloacid dehalogenase-like hydrolase 4-213 1.1e-07 23.8 Pfam-A 2-215 (215) alignment 
Range on Protein: 4-213
Range on HMM: 2-215/215.0
KAVFVDISGTLLVGNAAL--PGAIDALARLKQN----------YTVRLVTNTSKE-----------------------SQRAIYERLTTLGFAVEPSEVF
|.|. |. |||. |. ..  .|.  ||| ...             |.  .. | .                       ... . ..|.  ..|..  .. 
ktvvfDktGTLtegepsvallgnkaalalaaaletgsehpigkavvaaakanstrggltgfatfigrgvsgkvdgivlgnpewmtalglrviapdlvaae

TslaatralllR----------DqrrcffiippateedfadvprdspDTVVLGLAPDS-FDYATLDTGFQILRQPDARLIAINtSRFYATPSGVHIAAGA
.                                              . ..||.  ..   .  .   .. |..   ..  .  .    | . ..  || 
g..........qskgrtvvvvav........................qaralgviafadpvkpeaaeavasLkeaGievvllt.gdnpetaeaiakqagi

fvraleYAANVSAHVVGKPSAEFFRAAAASCHLDVESCVMIGDDTgDDFEGAMRAG
        ..| |.|||||. . |.||.    .| . ..|.||.   | ... .||
......edslvfaevvgkPepklfvaaieeLqidpgevamvGDgv.nDapalaaAg
HAD_2 Haloacid dehalogenase-like hydrolase 171-218 1.1e-07 23.6 Pfam-A 129-175 (176) alignment 
Range on Protein: 171-218
Range on HMM: 129-175/176.0
HVVGKPSAEFFRAAAASCHLDVESCVMIGDDTgDDFEGAMRAGLRAML
. . ||. |... ... .... | ...|.|   .|.|.|  ||.|. .
vgapKpdpeayekvlerlgvkpeeilfidDsl.edveaAraaGirtvh
CECR5_TIGR01456 2-78 2.2e-07 20.6 In-house 37-119 (370) alignment 
Range on Protein: 2-78
Range on HMM: 37-119/370.0
KTKAVFVDISGTLLVGNAALPGAIDALARLKQN-----YTVRLVTNTSKESQRAIYERLT-TLGFAVEPSEVFTSLAATRALL
|. .. .|| | || |.  ..|| .|| || ..       | |.||.   |.||  | |   ||  |.|  |  | .  . | 
kkfgfaldiDGvllrGkkpiagaskalrrLvddqGalkiPvllltngGglseraraeelsalLgvevsplqviqshsPykklv
subfamily_CUT_pd Subfamily CUT 4-77 7.1e-07 19.0 In-house 19-98 (391) alignment 
Range on Protein: 4-77
Range on HMM: 19-98/391.0
KAVFVDISGTLLVGNAALPGAIDALARLKQN-----YTVRLVTNTSKESQRAIYERLT-TLGFAVEPSEVFTSLAATRAL
 .. .|| | || |.  .|.| .|| .|...       | ..||..  ....  |.|  .|.. |.. .|. | .  . |
fgivlDiDGvLlRgkkvipaakealklledkkgelkvPvvfltnggnftekekaeklsekLdvevdadqvllshsPlkll
Subfamily.CECR5.protein 4-77 7.2e-07 19.0 In-house 21-100 (393) alignment 
Range on Protein: 4-77
Range on HMM: 21-100/393.0
KAVFVDISGTLLVGNAALPGAIDALARLKQN-----YTVRLVTNTSKESQRAIYERLT-TLGFAVEPSEVFTSLAATRAL
 .. .|| | || |.  .|.| .|| .|...       | ..||..  ....  |.|  .|.. |.. .|. | .  . |
fgivlDiDGvLlRgkkvipaakealklledkkgelkvPvvfltnggnftekekaeklsekLdvevdadqvllshsPlkll