Gene PGP in Monosiga brevicollis

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold HAD
Superfamily HAD
Family NagD
Subfamily PGP
Protein sequence
ID Type Fasta BLAST phosphatome Note
MbreP081_AA protein Get Run
MbreP081_AA_10-298 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_PGP_pd Subfamily PGP 17-297 5.3e-101 328.6 In-house 2-278 (279) alignment
Range on Protein: 17-297
Range on HMM: 2-278/279.0
FVFDCDGVIWRGATLIDGVADALDGLRRHGKRVAFITNNSTKTRANFVKKFHGLGLTWVERDDVWSSASAAAAYLTQrakLDKSRKVYVVGQSGLCEELC
..||||||.|.| |.|.| |.||. |...||.|.|.||||||.|....|||. ||...|......|||.|.|.||.|     .. ||||.|..||.|||.
vlfDcDGVlWlgetaipgaaealnaLkklgKkvlfvtNnstksreellkkfkklgfekvkeeeilssaaaiadyLkq...kkfekkvyvlgeeglkeeLk

EAGYTVLGGPDDEGSSVFP--VPERFEVDPAVGAVVVGFDRAINYYKLAYATMCARENKdCLFLATNRDAITHLNDEQEFPGGGTMVAALETAIGRAPEV
|||...||..... .. .   . |....|..|||||||.|....|.||..|... ||.. .||||||.||...|..|. .|| |..|||.|.|.||.| |
eagiellgtgpeklkdeldedfveelkldkdvgAVvvgvdeklsyakllkAanyLrepe.vlflatneDallplkkevvipgaGslvaaieaasgrkplv

AGKPSPFLVDALYAFHGLDRDsaHAVMVGDRLDTDIIFGNTNNMATLLVMSGVTRQSHVDATQPGEDDYPTYIAPSLKLLADT
 |||...|...|.  . .|..  ...|.||||.||| ||..... ||||.||||....|....  |...|.|...||. |...
lGKPnelllelllekeeidpe..rtlmiGDrlktDilfgkncGlqtLlvlsGvtkledveeikkeeklvPdyyldsladllel

Chronophin_1 16-298 1.4e-74 241.8 In-house 3-259 (261) alignment
Range on Protein: 16-298
Range on HMM: 3-259/261.0
LFVFDCDGVIWRGATLIDGVADALDGLRRHGKRVAFITNNSTKTRANFVKKFHGLGLTWVERDDVWSSASAAAAYLTQrakLDKSRKVYVVGQSGLCEEL
|. .|.|||...|.....| |...  |...||.| |.||||..||.........|||. |. . ..||| ||||.|.|    . . ||||.|..|| .||
lvLlDldGVlikgeeavpgAaeliealkqagkevlfvtNnsrrtreelaarlkrlGldavaaeeifssalaaaallrq...qaakakvyvlGeeglrkel

CEAGYTVLGGPDDegssvfpvperfevdpAVGAVVVGFDRAINYYKLAYATMCARENkdCLFLATNRDAITHLNDEqEFPGGGTMVAALETAIGRAPEVA
 |||... ..|.|                .| |||||.|. ... ||| |..  |.   .||.|||||  . |..    || |...||.|.| ||.| | 
reaGlrlvdeped................rveaVvvGydeelsfeklaeaialirdg..alfvatnrDptvPleeG.iaPgtGslaaaveaAsgreplvv

GKPSPFLVDALYAFHGLdrDSAHAVMVGDRLDTDIIFGNTNNMATLLVMSGVTRQSHVDATQpgEDDYPTYIAPSLKLLADTL
|||.|.. ..     |.  |....||||||||||| .|.   . ||||..||.... . |..  .|  |.... |.. |...|
GKPepvmfeealekiga..dpeetvmvGDRldTDilagaraglstllvltGvseleeaqayk..kdlrPdavvesiadlleel

Chronophin_2 17-272 2.2e-70 228.1 In-house 3-249 (282) alignment
Range on Protein: 17-272
Range on HMM: 3-249/282.0
FVFDCDGVIWRGATLIDGVADALDGLRRHGKRVAFITNNSTKTRANFVKKFHGLGLTWVERDDVWSSASAAAAYLTQRAKLdkSRKVYVVGQSGLCEELC
 .|||||||| | . . | .. .. | |.||.| |.|||||..| |.|.||  ||.. |  ....|||  .|||| . |..  . ||.|.|  || .|| 
vlfdcdgviwngekavagapevvsrlaragknvlfvtnnstrarenyvlkfarlgfadvaaeqifssaycsaaylrdvadv..rgkvfviggeglrkelr

EAGYTVLGGPDDEGSSVFPVPErfevDPAVGAVVVGFDRAINYYKLAYATMCAReNKDCLFLATNRDAITHLNDEQEFPGGGTMVAALETAIGRAPEVAG
|||  |.. .|.. .|.. ...    || | ||.||.|  . . ||| |.   | . |||.|||.||    |.| .  || |.. |||||| ||   | |
eagvpvvedadeqeasiydcal....dpdvravlvgydekltflklakacaylr.dadclllatdrdpwhplsdgritpgsgsltaaletasgrkatvig

KPSPFLVDALYAfhGLDRDSAHAVMVGDRLDTDIIFGNTNNMATLLVMSGVTRQSH
|||.|. . .     .. | |...|.||||.|||.||.   ..|.| ..||..   
kpsrfmfeciss..qfsvdparslmigdrletdilfgsncglstvltltgvsslee

Hydrolase_6 Haloacid dehalogenase-like hydrolase 17-120 4.1e-33 104.8 Pfam-A 1-100 (101) alignment
Range on Protein: 17-120
Range on HMM: 1-100/101.0
FVFDCDGVIWRGATLIDGVADALDGLRRHGKRVAFITNNSTKTRANFVKKFHGLGLTwVERDDVWSSASAAAAYLTQRaklDKSRKVYVVGQSGLCEELC
|.||.|||.||| ..|.|.|.||. ||..||.|...||||.|......||.. ||.  |. ..|..||.|||.|| .|   .. .||.|.|. ||.||| 
flfDvdGvLwrgdkaipgaaealkalraagkpvvllTNnsskseeeyakkleklgvd.vteeqvvtsataaaeylkkr...kadkkvlvigeeglreelk

EAGY
|||.
eaGf

subfamily_LHPP_pd Subfamily LHPP 17-271 3.5e-26 83.5 In-house 1-224 (227) alignment
Range on Protein: 17-271
Range on HMM: 1-224/227.0
FVFDCDGVIWRGATLIDGVADALDGLRRHGKRVAFITNNSTKTRANFVKKFHGLGLTwVERDDVWSSASAAAAYLTQRAKldksRKVYVVGQSGLcEELC
.. |  ||.. . . | | ..||. ||..|..| |.||.. ..... |..   ||.  || ... .|..||...| .|      |....| ..   |.. 
vllDlsGvlhnedaaipgavealkrLrqagvkvrfvtNttkeskralverLirlgfd.veeeeiftsleaarqllrerkl....rpyllveddve.edfe

EAGYTVLggpddegssvfpvperfevdpavGAVVVGFD-RAINYYKLAYATMCARENKDCLFLATNRDAITHLNDEqEFPGGGTMVAALETAIGRAPEVA
.  .                           |||.|    ...| .|  |   . |.|.   .| |..   . .|     | |. |.||| |.|   || 
didtdkp.......................navviglapesfeyetlnqafrllleakkakliainkgkyykrkdG.lalgpGafvkaleyatgvkaevv

GKPSPFLVDAlyAFHGLDRDSAHAVMVGDRLDTDIIFGNTNNMATLLVMSGVTRQS
||||... ..  | . |. | ..|||.|| .  |.    .  . ..|| .|. |..
GKPsalffek..aleelgvdpeeavmiGDdvedDveGAlkaGlrgvlVktGkfrpe

Hydrolase_like HAD-hyrolase-like 215-291 9.7e-17 52.0 Pfam-A 2-72 (75) alignment
Range on Protein: 215-291
Range on HMM: 2-72/75.0
AGKPSPFLVDAlyAFHGLDRDSAHAVMVGDRLDTDIIFGNTNNMATLLVMSGVTRQSHVDAtqpgEDDYPTYIAPSL
 |||.|...|.  | . |. .....||.||.|.|||...|  .. ..|| .||.|.   ..    .   |.|....|
lgKPnpgmydk..alevlgappsevvmiGDslatDieaAnnaGirsilVltGvsreedlkl....akakpdyvvddl

subfamily_CUT_pd Subfamily CUT 11-83 5.3e-07 19.4 In-house 15-91 (391) alignment
Range on Protein: 11-83
Range on HMM: 15-91/391.0
IESTKLFVFDCDGVIWRGATLIDGVADALDGLRRH-GK---RVAFITNNSTKTRANFVKKFHGLGLTWVERDDVWSS
 .|.  .|.| |||. ||  .| .. .||  | .. |.    | |.||..  |  .  .|   .  . |. |.|  |
sassfgivlDiDGvLlRgkkvipaakealklledkkgelkvPvvfltnggnftekekaeklsekLdvevdadqvlls

Subfamily.CECR5.protein 11-83 6.3e-07 19.2 In-house 17-93 (393) alignment
Range on Protein: 11-83
Range on HMM: 17-93/393.0
IESTKLFVFDCDGVIWRGATLIDGVADALDGLRRH-GK-R--VAFITNNSTKTRANFVKKFHGLGLTWVERDDVWSS
 ...  .|.| |||. ||  .| .. .||  | .. |. .  | |.||..  |  .  .|   .  . |. |.|  |
sakkfgivlDiDGvLlRgkkvipaakealklledkkgelkvPvvfltnggnftekekaeklsekLdvevdadqvlls