Gene CDC14-1 in Nematostella vectensis

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family DSP
Subfamily CDC14
Protein sequence
ID Type Fasta BLAST phosphatome Note
NvecP002_AA protein Get Run
NvecP002_AA_7-157 phosphatase_domain Get Run
NvecP002_AA_176-334 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_CDC14_pd Subfamily CDC14 9-335 5.1e-176 579.3 In-house 2-328 (328) alignment 
Range on Protein: 9-335
Range on HMM: 2-328/328.0
NAHEIIKDRLYFATFRHKPHSTSHIHYFSIDDELIYENFYADFGPLNLAMLYRYSCKLNKKLKSFSLGKKKIVHFTSTDSRKRANAACLIGSYAVIYLKK
||.|...|||||||.|.||.|||..||||.||||.||||||||||||||.||||..|||||||| .  .||||..||.||.||||||.|||.||||||||
nalelledrlyfatlrkkPkstselhyfsvddelkyenfyadfGPlnlavlyrycvklnkkLkseekaskkivlytsadskkranaalligayaviylkk

SADEIYQTLNTGCNPPYLPFRDASFGACSYNLSILDVLSGLQKALQNDFFNLDTFDVHEYEYYERVENGDFNWIVPGKFLAFSGPHNKSRIKDGYPLHAP
.|.|.|..|... .||..||||||.|..||.|..||||.|..||||..|..|..||..|||.||||||||||||||.||||..||||||...||||||||
taeeayraleaaetppfvpfrdasygsasykltlldvlkgvekalqkgfldledfdleeYekyervenGDfnwivPdkflalagPhnkskledgyplhaP

EAYIPYFKKHNISTVVRLNKKLYDAQRFTDHGIEHYDLFFIDGSVPSDMIVRRFLTIAENAKGGIAIHCKAGLGRTGTLIACYLMKHYRFTAAESIGWLR
|....||.|.|..||||||||||||..|||.|..|.||||||||.|||.||..||.|||.|.|.||.|||||||||||||||||||||||||||.|.|||
eklleyfrknnvttvvrLnkklYdakkftdaGfdhkDlffiDGstPsdaivkkfleiaekaeGaiavhCkaGLGrtGtLiacylmkhyrftaaeaiawlr

VCRPGSIIGPQQNFCEEKQASLWIQGD
.|||||.|||||.|.|||||.|| .||
icrPGsvigpqqkfleekqaalwlegd
DSPn Dual specificity protein phosphatase, N-terminal half 12-152 1e-61 197.7 Pfam-A 2-141 (141) alignment 
Range on Protein: 12-152
Range on HMM: 2-141/141.0
EIIKDRLYFATFRHKPHSTSHIHYFSIDDELIYENFYADFGPLNLAMLYRYSCKLNKKLKSFSLGKKKIVHFTSTDSRKRANAACLIGSYAVIYLKKSAD
|.|.|||||.....||..|...||||||.||.||.|||||||||||..||...|||||||. .| |||||..||.|..||||||.|||.||||.||.|..
eliedrLyfvslkkkpkktenthyfsiDeelvYepfyadFGPlnlaqiyrfcvklnkkLkeaelkkkkivlytsldekkranaalLigaYavivlklspe

EIYQTLNTGCnPPYLPFRDASFGACSYNLSILDVLSGLQKA
|... |...  |..|||||||.|...|.|.|||.|.||.||
ealkplesve.psllpFrDAsygestyeltildclkglekA
0048567 (Phosphotyrosine protein) phosphatases II 6-161 5.3e-56 183.1 In-house 3-157 (157) alignment 
Range on Protein: 6-161
Range on HMM: 3-157/157.0
ELSNAHEIIKDRLYFATFRHKPHSTSHIHYFSIDDELIYENFYADFGPLNLAMLYRYSCKLNKKLKSFSLGKKKIVHFTSTDSRKRANAACLIGSYAVIY
|. .. |||.||||||.....|.|. . .||||||.|.||.|..||||||||.|||. .||||.||...| .|.|....... .||...|.|||.|....
engdlieiipdrlyfallprlpkslynalyFsiddglvyedfffdfGPlnlailyrFilklnkflkilelagkaiavhckaglkkrgrtatLigcYlilh

LKKSADEIYQTLnTGCNPPYLPFRDASFGACSYNLSILDVLSGLQKALQNDFFNLD
|.....|... |   ..|...||||||.. . |||..||||.||.|||...|..|.
lgftpeeaiapl.rivrpgsvpfrdasyllslynltlldvlyGllkAlelgfldle
0038934 (Phosphotyrosine protein) phosphatases II 166-324 4.7e-44 145.7 In-house 4-167 (194) alignment 
Range on Protein: 166-324
Range on HMM: 4-167/194.0
HEYEYYERVENgdfnwIVPGKFLAFSGPHNKSRIKDG--YPLHAPEAYIPYFKKH--NISTVVRLN--KKLYDAQRFTDHGIEHYDLFFID-GSVPSDMI
.....||||..     |..|.|.||..|...|  |    .  ..|| .. |.| .  .. .|..|.  ...||...|...|||...|.|.| |.|||. |
drwlkyervgd.....iitgrfiafkvPlsgsldkyieelyrfspedlvrylkllnvklglvidltnteryYdpeefekagieylklpfpddgtvPslei

VRRFLTIA-----ENAKGGIAIHCKAGLGRTGTLIACYLMKHYRFTAAESIGWLRVCRPGSIigPQQNFCE
..||| ..     |...| .|.||||||||||||.|.||.......| |.|...| .|||.|  |.|.. |
llrfldlvdeflnedpggvvaVHCkaGlgRtGtlvaaYLiyrlgmsaeeAialfrekRpgai..pnqdyle
0041856 (Phosphotyrosine protein) phosphatases II 163-336 9.1e-44 144.6 In-house 2-175 (182) alignment 
Range on Protein: 163-336
Range on HMM: 2-175/182.0
FDVHEYEYYERVENGDFNWIVPGKFLAFSGPHNKSRIKDGYPLHAPEAYIPYFKKHNISTVVRLNKKLYDAQRFTDHGIEHYDLFFIDGSVPSDMIVRRF
.| ..|. . ..... ... .  .....| |...  .  |..|. ........|...|.|.|.|.  ||........||....|.. |..||.  .. .|
ldknrysdilpydhsrdldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlteelywpellerlgiqylylpwpDhgvpdldelldf

LTIAENAKGGIAIHCKAGLGRTGTLIACYLMKHYRFTAAESIGWLRVCRPGSIIGPQQNFCEEKQASLWIQGDI
. .... .| ...||.||.||||||.|.||||...... | . ..| .|||..| |.|.| .  .. .......
ieevleeggpvlVHCsaGvgRtgtlvaaylmkklgvsleeavklvrsrRpgmvitpnqyfflqlallellllkk
0049772 (Phosphotyrosine protein) phosphatases II 124-326 5.6e-42 139.9 In-house 65-266 (314) alignment 
Range on Protein: 124-326
Range on HMM: 65-266/314.0
PYLPFRDASFGACSYNLSILDVLsGLQKALQNDFFNLDTFDVHEYEYYERVENGDFNWIVPGK---------------------FLAFSGPHnksrikdG
|.||... ..  .||  ..|. .   |. |.. ........| .|.....|..||.|......                     .| ..|..       .
pglpvsgsdyinasyvdgflkfI.atqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivmsrdevladelsrLdaAlgKtpllildgng.......n

YPlhaPEAYIPYFKkhnistvvrlnKKLYDAQRFTDHGIEHYDLFFIDGSVPSDMIVRRFLTIAEN--AKGGIAIHCKAGLGRTGT-LIACYLMKHYRFT
.|   ..|.....|           . |||...|...||..... . |||.|.. ....|| . |.  ..| ...||||| ||||| ..|.||||.....
ep...taadlellk...........eelydpelferlgikylripvpDgsaplledfdeflefieeadkggpvlvHCkaGkgRtgtfvvaaylmkllgvs

AAESIGWLRVCRPgsiIGPQQNFCEEK
..| . ..| .||   |.|...| |  
leealedvrlkRp...inpnpgfieql
0050432 (Phosphotyrosine protein) phosphatases II 121-320 1e-39 132.1 In-house 7-287 (308) alignment 
Range on Protein: 121-320
Range on HMM: 7-287/308.0
CNPPYLPFRDASFGACSYNLSILDVLSGLQKALQNDFFN------LDTFDVHEYEYYERVENGDFNW-------------------------------IV
  ...|.|||.|. ..|..||.||.|  |.|||.. ...      |......||......||.|.|.                               ..
allelllfrdtsilvsslklsvldllkllekaldlglleeefeellsvkplleysvallpenkdkNrykdilpydhsRVkldegsdYInAsyvdgysskl

PGKFLAFSGPHnksrikdgypLHAPEAYIPYFKKHNISTVVRLNKKLYD-----AQRFTDH---GIEHYDLFFI--------------------------
| ||.|. ||.           .  | .. .. ..|....|.|.|  ..     || . .    |...|. |..                          
prkfIatqgPl..........pntvedFwrmvweqnvrvIvmLtklvengrekcaqYwplelgggsleygkftvtllseevlddytvrtleltnlgdges

------------DGSVPSD-MIVRRFLTIAENA--KGGIAIHCKAGLGRTGTLIACYLM-----KHYRFTAAESIGWLRVCRPGSIIGPQQ
            |..||..  |. .|| ....   .| |..||.||.|||||.||..|.     |...... | . .|| .|||....|.|
rtvthfhytnWpdhgvPpspeilldflelvrkslpggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtpeq
0045450 (Phosphotyrosine protein) phosphatases II 122-320 3.4e-38 127.5 In-house 2-292 (307) alignment 
Range on Protein: 122-320
Range on HMM: 2-292/307.0
NPPYLPFRDASFGACSYNLSILDVLSGLQKALQnDFFNLDTFDVHEYEYYERVENGDFNWI---------------------------------------
..|. .|.|| .. . ..| .|| |.||.|. . ..... .|...||......||.|.|..                                       
dlplslfidalkllllvllllldfltgllkefe.kllsvtvfllgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvplllll

----VPGKFLAFSGPHNKsrikdgyplhAPEAYIPYFKKHNISTVVRLNKKLYDAQR------------------------------------------F
    .. ||.|. ||...           .| .. ..........|.|..  .....                                          .
dgydlkrkfIatqgPlpe..........tvedFwrmlweqgvtvivmltelvelgrekcaqywPdegeeltygnftvtllseehldgytvrtlevtdldg

TDHGIEHYDLFF---IDGSVPSD-MIVRRFLTIAEN------AKGGIAIHCKAGLGRTGTLIACYLMKHYR--------FTAAESIGWLRVCRPGSIIGP
|. ..... ...    |..||..  .. .|. ....       .| ...||.||.|||||.||.|||....        ... | . .|| .|||..  |
tgesrtvthfhytgwpdhgvppsfeelldfieevrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnp

QQ
.|
eq
0045098 (Phosphotyrosine protein) phosphatases II 151-332 7.1e-38 126.0 In-house 8-273 (278) alignment 
Range on Protein: 151-332
Range on HMM: 8-273/278.0
KALQNDFFNLDTFDVHEYEYYERVENGDFNWIV----------------------PGKFLAFSGPHNksrikdgyplHAPEAYIPYFKKHNISTVVRLNK
..|.  .|.| .... |.... ...|.|.|...                      | ||.|. ||..          .  .... ......|...|.|..
dlllefefllllgipseitpalylgnldknRykdilpydhsrVkdYINAsyidgypkkfIatqgPlp..........stvadfwrmlwelgitvivmlte

KLYDA----------------------------------------------QRFTDHGIEHYDL-FFIDGSVPSDMIVRRFLTIAE--------------
 ....                                              . .. .|..|... .. |..|||. |.. || . |              
lvelgrekcaqywpeggsltygdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslll

------NAKGGIAIHCKAGLGRTGTLIACYLMKHY---RFTAAESIGWLRVCRPG-SI-IGPQQNFCEEKQASLWI
      . .| ...||.||.||||||.|.|||...   .... | . .|| .||| .. .  |..|..| .. |. 
sslllldsggpvlVHCsaGvgRtGtlvaaylmlelleggvdlleavkelrsqRpglavqnleqyrflyefllelll
0040438 (Phosphotyrosine protein) phosphatases II 136-320 7.9e-38 125.9 In-house 3-264 (317) alignment 
Range on Protein: 136-320
Range on HMM: 3-264/317.0
CSYNLSILDVLSGLQKALQNDFFNLDTFDVHEYEYYERVENGDFNWIV----------------------------------PGKFLAFSGPHNKsrikd
....| .||.| .  .||.. |..|.......|...|..||.|.|...                                  . ||.|..||...     
ldlllalldllksdftalleefedllslkldtysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyvdgpnlkrkfIatqgPlpn.....

gyplhAPEAYIPYFKKHNISTVVRLNKKLYD------------------------AQRFTDHGIEHYDLFF-------------------IDGSVP-SDM
       | .. ..........|.|..  ..                         . ....||... | .                    |..|| |  
.....tvedFwrmvweqgvtvivmLteleelgrekcaqYwplgetltygdftvtllseeelagitlrtlevedlgdsesrtvthfhytgWpdhgvppspd

IVRRFLTIAENA----KGGIAIHCKAGLGRTGTLIACYLM-----KHYRFTAAESIGWLRVCRPGSIIGPQQ
.. .|| ....|    .| ...||.||.|||||.||.|||     |...... | . .|| .|||..  |.|
llldfleavrealedpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeq
0044763 (Phosphotyrosine protein) phosphatases II 163-335 3.4e-37 123.2 In-house 7-175 (178) alignment 
Range on Protein: 163-335
Range on HMM: 7-175/178.0
FDVHEYEYYERVENGDFNWIVPGKFLAFSGPhnksrikdgyplhapEAYIPYFKKHNISTVVRLNKKLY------DAQRFTDHGIEHYDLFFIDGSVPS-
......|..||... ....|.|| .|.  .|               .......|...|...|.|.. |.      |.. ....||... . . |..||. 
vllsnleglersdyinaseilpglylgslpp...............addlellkelgithivnlteelelgflkcdpywpeeagiqylhipipDhgvpdl

DMIVRRFLTIAE----NAKGGIAIHCKAGLGRTGTLIACYLMKHYRFTAAESIGWLRVCRPGSIIGPQQNFCEEKQASLWIQGD
. ....|. . |    . .| ...||.||.||.|||.|.||||...... | | ..| .||...   |.....| .  |. ..|
lehflefvefieealdekggpvlVHCsaGvgRsgtlvaaylmkklglsleeaielvrerRpivpnpgqlrqLyefelrllkesd
0039614 (Phosphotyrosine protein) phosphatases II 125-320 1.1e-36 122.2 In-house 1-277 (297) alignment 
Range on Protein: 125-320
Range on HMM: 1-277/297.0
YLPFRDASFGACSYNLSILDVLSGLQKALQNDFFNLDTFDV----HEYEYYERVENGDFNWIV------------------------------------P
|||.|||... ... ||.||.| .| ||... .. |. ...    ..|......||.|.|...                                    .
ylplrdallesipiplsvldlllllekansktllllefeellslkpdysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydllt

GKFLAFSGPHNKsrikdgyplhAPEAYIPYFKKHNISTVVRLNKKLYDAQ----------------------RFTDHGIEHYDLFF--------------
 ||.|..||...           .| .. ..........|.|.|  .. .                       ....|. .. |                
rkfIatqgPlpe..........tvedFwrmvweqgvtvivmLtklvelgrkcaqywpeeggtygdftvtllkvehldgytvrtlevtnngesrtvthfqy

---IDGSVP-SDMIVRRFLTIAEN------AKGGIAIHCKAGLGRTGTLIACYLM-----KHYRFTAAESIGWLRVCRPGSIIGPQQ
    |..|| |  .. .|| ....       .| ...||.||.|||||.||.|||     |...... | . .|| .|||..  |.|
tgwpdhgvppslellleflelvrealaelpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsq
0043336 (Phosphotyrosine protein) phosphatases II 134-320 4.4e-36 120.2 In-house 3-265 (278) alignment 
Range on Protein: 134-320
Range on HMM: 3-265/278.0
GACSYNLSILDVLSGLQKALQNDFFNLDTFDVHEYEYYERVENGDFNWIV----------------------------------PGKFLAFSGPHNKsri
. ...   .|..| .|...|...|..|..|.. .|......||.|.|...                                  | ||.|..||...   
svkdllkallelllnlktllllefeellsfkldtysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyvdgynvprkfiatqgPlpe...

kdgyplhAPEAYIPYFKKHNISTVVRLNKKL--------------------------------------------YDAQRFTDHGIEHYDLFfiDGSVP-
        .| .. ........|.|.|..                                              .| . .| ... ...    |..|| 
.......tvedFwrmvwelgvttivmLtelvelgrvkcaqYwpggsltygdftvtllkeehlddytvrtlevtnlgdgesrtvthyhylgwp..dhgvpe

SDMIVRRFLTIAEN----AKGGIAIHCKAGLGRTGTLIACYLM-----KHYRFTAAESIGWLRVCRPGSIIGPQQ
|  .. .|| .. .     .| ...||.||.|||||.||.||.     |...... | . .|| .|||..  |.|
slsllldflkavrealedsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsq
0043147 (Phosphotyrosine protein) phosphatases II 167-323 1.1e-35 118.3 In-house 3-152 (172) alignment 
Range on Protein: 167-323
Range on HMM: 3-152/172.0
EYEYYERVENGDFNWiVPGKFLAFSGPhnksrikdgyPLHAPEAYIPYFKKHNISTVVRLNKKLYDAQRFTDHGIEHYDLFFIDGSVPSDMIVRRFLTIA
|...|..... |... .| .|.|. ||            .  . .. ..|...|...|.|.. |||.. ....||... | . |..||.  ....|| . 
egsdyinasyldlyy.ipdrfiatqgp..........lrntladfwrmlkelgithivnltellydpellerlgiqylylpwpDhgvpllellleflefi

EN-----AKGGIAIHCKAGLGRTGTLIACYLMKhYRFTAAESIGWLRVCRPGSIIGPQQNFC
..      .| ...||.||.||||||.|.|||. ..... | . ..| .|||..  |.|  .
dellalspggpvlVHCsaGvgRtgtlvaaylml.lglsleeavalvrekRpgavqnpsqyrf
0048567 (Phosphotyrosine protein) phosphatases II 213-331 2.2e-35 116.2 In-house 10-138 (157) alignment 
Range on Protein: 213-331
Range on HMM: 10-138/157.0
PYFKKHNISTVVRLNKKLYDAQRF-TDHGIEHYDLFFIDGsvPSD--------MIVRRFLTIAENAKGGIAIHCKAGL---GRTGTLIACYLMKHYRFTA
 ......  ...||.|.||.|  | .|.|. ..|.|| .|  | .        ... .|| | |.|.. ||.||||||   |||.|||.|||..|..||.
iipdrlyfallprlpkslynalyFsiddglvyedfffdfG..PlnlailyrFilklnkflkilelagkaiavhckaglkkrgrtatLigcYlilhlgftp

AESIGWLRVCRPGSIIGPQQNFCEEKQASLW
.| |..||..||||...... . . ..  ..
eeaiaplrivrpgsvpfrdasyllslynltl
0049260 (Phosphotyrosine protein) phosphatases II 194-323 4.8e-33 109.4 In-house 8-141 (152) alignment 
Range on Protein: 194-323
Range on HMM: 8-141/152.0
HNKSRIKDGYPLHAPEAYIPYFKKHNISTVVRLNKKLYDAQRFTDHGIEHYDLFFIDGSVPSDMIVRRFLTI-----AENAKGGIAIHCKAGLGRTGTLI
...  .  |.  .  . .. ..|...|.|.|.|.. |...  .....|... |.. |..||.. .. .|| .     |.. .| ...||.||.||||||.
pfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyiqylhlpwpDhgvpdlsqlllflllfieklaldkggpvlVHCsaGvgRtgtlv

ACYLMKhYRFTAAESIGWLRVCRPGSIIGPQQNFC
|.|||. ..... | . ..| .|||... |.| . 
aaylml.lgvsleeavalvrekRpgavpnpgqlrf
0051082 (Phosphotyrosine protein) phosphatases II 178-324 1.7e-32 107.4 In-house 7-145 (151) alignment 
Range on Protein: 178-324
Range on HMM: 7-145/151.0
DFNWIVPGkFLAFSGPHNksrikdgyplhapeAYIPYFKKHNISTVVRLNKKL---YDAQRFTDHGIEHYDLFFIDGSVPSD----MIVRRFLTIAENA-
.|... .| .....||..              ......|...|.|.| |...    |........|||.... ..| ..|.      .|..|| ....  
nfsyvtgg.lyrsggpla..............dflellkelgiktivnlrseeergycpeylpelgievlhipildwpdpglplsfdavleflellldkk

KGGIAIHCKAGLGRTGTLIACYLMKhYRFTAAESIGWLRVCRPGSIIGPQQNFCE
.| ...||.||.||||||.|.|||. ......| . ..| .|||... .|| ...
ngpvlvHCsaGkgRTGtlvalylml.lgvsleealeeyrlkrpgvvqpnqqflfq
0036282 (Phosphotyrosine protein) phosphatases II 171-320 8.6e-32 105.6 In-house 4-158 (174) alignment 
Range on Protein: 171-320
Range on HMM: 4-158/174.0
YERVENGDFNWIVPgKFLAFSGPHNksrikdgyplhapeaYIPYFKKHNISTVVRLNKKLYDA------------QRFTDHGIEHYDLFFIDGSVPSDMI
|... . |...| | ...|..||..               .....|...|.|||.|..  ..             . ....||....| . |..||.. |
yinaspldlsyitp.rliagqgpla...............fwemlkelgittvvmlleekelglykcinywpelredlerlgiqylylpwpDhgvpdlsi

VRRFLTIAENA-----KGGIAIHCKAGLGRTGTLIACYLMKHYRF-TAAESIGWLRVCR---PGSIIGPQQ
...|. ..|.|     .| ...||.||.||||||.|.|||... . .. . . ..| .|   ||... |.|
llefvkfveealsedpggpvlVHCsaGvgRtGtlvaaylmlrglleslvdaldlvrelRlqrpgmvqtpsQ
PTEN_1 172-330 2.5e-31 104.0 In-house 18-191 (196) alignment 
Range on Protein: 172-330
Range on HMM: 18-191/196.0
ERVENGDFNWIVPGKFLAFSGPH----NKSRIKDgyPLHAPEAYIPYFKKHNISTVVRLNKKL------YDAQRFTDHGIEHYDLFFIDGSVPSDMIVRR
| .... ... . ... |.| |      ......  .|. ..|.   .|...| .||.|. .       || . | ..|.|.... . |  .||   . .
elldltyitsriiamgkapsrpllqeideglyrg..slkdvaadldnlkedgitlvvnlseeeelsgrsydleeffksgveylhfpieDhgapslselfd

FLTIAENA------KGGIAIHCKAGLGRTGTLIACYLMKHYRFTAAESIGWLRVCR-PGSIIGPQQNFCEEKQASL
..  ....      .. ...||||||||.||..|.|||.....|| | . ..| .| ||..  |.|. ..| .|.|
icksfiewllsdpngnvVlVHCkaGlgRsGtvvaayLmykgkltadeAlelvrekRppgapnspsqerlleyfael
0040439 (Phosphotyrosine protein) phosphatases II 167-320 3.3e-31 104.2 In-house 2-234 (249) alignment 
Range on Protein: 167-320
Range on HMM: 2-234/249.0
EYEYYERVENGDFNWIV----------------------------------PGKFLAFSGPHNKsrikdgyplhAPEAYIPYFKKHNISTVVRLNKKL--
||......||.| |...                                  . .|.|..|| ..          . |... ......|...|.|..    
eysvallpenkdknrypdilpydhsrvklsilpglflsdyinAsyidgyyikrrfiatqgPlpe..........tvedfwrmlwelgitvivmLtslvel

-------------------------------------------YDAQRFTDHGIEHYDLFfiDGSVP-SDMIVRRFLTIAEN------AKGGIAIHCKAG
                                           || . .| ..| ..|.   | .|| |  .. .|. ....       .| ...||.||
grekcaqywplggsleygdftvtllsvevkddytvrtleltnlydgesrtvlhiqytdwp..dhgvppsfedlldfieavrkaleelpkggpvlVHCsaG

LGRTGTLIACYLM-----KHYRFTAAESIGWLRVCRPGSIIGPQQ
.|||||.||.|||     |...... | . .|| .|||..  |.|
vgRtGtfiaaylmleqlekelgvdleeavkllrsqRpgavqnpeq
0042113 (Phosphotyrosine protein) phosphatases II 168-320 6.4e-31 103.0 In-house 1-231 (245) alignment 
Range on Protein: 168-320
Range on HMM: 1-231/245.0
YEYYERVENGDFNWI----------------------------------VPGKFLAFSGPHNKsrikdgyplhAPEAYIPYFKKHNISTVVRLNKKLYD-
|......||.|.|..                                  ...||.|..||...           .|... ......|.|.|.|..  .. 
ysvallpenkdknrysdilpydhtrvklspdggdldsdyinasyvdgyritpkfiatqgPlpe..........tvedfwrmlwelgittivmLteeeelg

------------------------------------------AQRFTDHGIEHYDLFFIDGSVPS-DMIVRRFLTIAEN-----AKGGIAIHCKAGLGRT
                                             .. ..| .. | . |..||. . .. .|| ....     ..| ...||.||.|||
rvkcaqywplgesltygdftvtllseehlddytvrtlevtnlgddesrevihyhylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRt

GTLIACYLM-----KHYRFTAAESIGWLRVCRPGSIIGPQQ
||.||.|||     |...... | . .|| .|||..  |.|
GtfiaaylmleqlekelgvsleeavkelrsqRpgavqtpsq
0037934 (Phosphotyrosine protein) phosphatases II 172-320 7.4e-31 103.0 In-house 32-230 (243) alignment 
Range on Protein: 172-320
Range on HMM: 32-230/243.0
ERVENGDFNWIVPgKFLAFSGPHNKsR-IKdgyplhAPEAYIPYFKKHNISTVVRLNKKL----------------------------------------
.   |... ...| .. |..||...           ...... ......|...| |..                                          
sdyinanliyvtp.rliatqgPlpe.tved......dlasfwrmlwelgitvivmltelvElgrekcaqywpgevtygdftvtllseehlddytvrtlll

--YDAQRFTDHGIEHYDLFFIDGSVPS-DMIVRRFLTIAE------------NAKGGIAIHCKAGLGRTGTLIACYLMKHY-RFTAAESIGWLRVCRPG-
  .|.. .| ..| .. | . |..||.   .. .|| ..             . .| ...||.||.||||||||.|||... .... | . .|| .||| 
enldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRtGtliaaylmllllgvdleeavkllreqRpgk

SIIGPQQ
..  |.|
avqtpsq
0046846 (Phosphotyrosine protein) phosphatases II 171-320 1.2e-30 102.0 In-house 4-161 (176) alignment 
Range on Protein: 171-320
Range on HMM: 4-161/176.0
YERVENGDFNWIVPGKFLAFsgphnKSRIKDGYPLHAPEAYIPYFKKHNISTVVRLNKK--------LYDAQRFTDHGIEHYDLFFIDGSVPSDMIVRRF
.......|...|... .|       .  ...|   .  .... ..|...|..||.|..          .. ......||... | . |..||.. .. ..
rllgldldldyinanlilgs.....rpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgiqylhlpwpDhgvpdlelllel

LTIAENAK---GGIAIHCKAGLGRTGTLIACYLMKH-YRFTAAESIGWLRVCRP-GSIIGPQQ
| . ..|    | ...||.||.||||||.|.||... . ... | . ..| .|| |..  |.|
lefirealkeggpvlVHCsaGigRtgtlvaayllelekglsveealalvreqRplgavqtpeQ
0048179 (Phosphotyrosine protein) phosphatases II 211-320 6.1e-28 92.7 In-house 21-133 (144) alignment 
Range on Protein: 211-320
Range on HMM: 21-133/144.0
YIPYFKKHNISTVVRLNKKlYDAQRFTDHGIEHYDLFFIDGSVPSD-MIVRRFLTIAENA---KGGIAIHCKAGLGRTGTLIACYLMKHYRFTAAESIGW
 ....||..|.||..|. . |. . ....||... | . | .||..  ....|| . |.|   .| ...||.||.||||||.|.||||...... | . .
dlellkklgittvinltee.yepefleregiqylhlpwpDhgvpdllellleflefieealeeggpvlVHCsaGvgRtgtlvaaylmkklglsleealal

LRVCRPGSIIGPQQ
.| .|||... |.|
vrsrrpgavpnpgq
0048076 (Phosphotyrosine protein) phosphatases II 211-320 5.6e-27 89.6 In-house 21-131 (145) alignment 
Range on Protein: 211-320
Range on HMM: 21-131/145.0
YIPYFKKHNISTVVRLnkkLYDAQRFTDHGIEHYDLFFIDGSVPSD-MIVRRFLTIAENA---KGGIAIHCKAGLGRTGTLIACYLMKHYRFTAAESIGW
 ....|...| ||..|    .. . ....||... | . | .||..  ....|| . |.|   .| ...||.||.||||||.|.|||....... | . .
dlellkdlgittvlnl...tselellerlgiqylylpwpDhgvpdllellleflefieealkeggpvlVHCsaGvgRtgtlvaaylmlllgvsleealel

LRVCRPGSIIGPQQ
.| .|||... |.|
vrsqrpgavpnpgq
0047943 (Phosphotyrosine protein) phosphatases II 161-320 7.5e-27 89.9 In-house 23-260 (273) alignment 
Range on Protein: 161-320
Range on HMM: 23-260/273.0
DTFDVHEYEYYERVENGDFNWI------------------------------VPGKFLAFSGPHnksrikdgypLHAPEAYIPYFKKHNISTVVRLNKKL
.......|......||.|.|..                              .. ||.|. ||            .  | .. .....|....|.|..  
slkplltysvallpenkdknrykdilpydhsrvklgdggsdyinAsyvdgynlkrkfiatqgPl..........pntvedfwrmvweqnvrviVmLtelv

YDAQ-----RFTDHG---IEHYDLFFI--------------------------------------DGSVP-SDMIVRRFLTIAEN------AKGGIAIHC
.. .      . . |    . |. |..                                      | .|| |  .. .|. ....       .| ...||
elgrekcaqYwpleggelsltygkftvtllseetkddytvrtleltnlgtgesrtvthfhytgwpdhgvppslesllefielvrkalealpsngpvvVHC

KAGLGRTGTLIACYLM-----KHYRFTAAESIGWLRVCRPGSIIGPQQ
.||.|||||.||..|.     |...... | . .|| .|||... |.|
saGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeq
subfamily_PRL_pd Subfamily PRL 209-328 2e-20 67.4 In-house 24-147 (151) alignment 
Range on Protein: 209-328
Range on HMM: 24-147/151.0
EAYIPYFKKHNISTVVRLNKKLYDAQRFTDHGIEHYDLFFIDGSVPSDMIVRRFLTI-----AENAKGGIAIHCKAGLGRTGTLIACYLMKHyRFTAAES
| .|  .||....||||  .  ||.. . ..|||  || | ||.||.. .|...|..     .|..|  .|.|| |||||.  |.|  |. .  ..  ..
ekfieelkkeevktvvrvceptydteklekegievldlafddGavPpeevveeWlellkekfkeepkstvavhcvaGlGraPvlvalaliea.Gmkyeda

IGWLRVCRPGSIIGPQQNFCEEKQA
. ..|  | |.|   | .| |. .|
vefirekrrgainskqlkflekyka
0046845 (Phosphotyrosine protein) phosphatases II 176-320 4e-20 67.8 In-house 28-262 (284) alignment 
Range on Protein: 176-320
Range on HMM: 28-262/284.0
NGDFNW----------------------------------------IVPGKFLAFSGPHNKsrikdgyplhAPEAYIPYFKKHNISTVVRLNKKLY----
| . |                                         ... ||.|..|| ..            | .     ..|....| |..       
nlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpn..........tvedFwrmvweqnvrvIVmltelvengre

-------------------------------------------DAQRFTDHGIEHYDLFfiDGSVP-SDMIVRRFLTIAENA------KGGIAIHCKAGL
                                           . . .| . . . .    | .|| |  .. .|| .....      .| |..||.||.
kcaqYwplegevltygdftvtllseevkddytvrtleltnlgytgesrtvthfhytswp..dhgvppspedlleflrlvrellenlpgggpivVHCsaGv

GRTGTLIACYLMKHY--------RFTAAESIGWLRVCRPGSIIGPQQ
|||||.||..|....        .... | . .|| .|||..  ..|
gRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleq
0051299 (Phosphotyrosine protein) phosphatases II 184-320 2.7e-19 65.2 In-house 91-274 (288) alignment 
Range on Protein: 184-320
Range on HMM: 91-274/288.0
PGKFLAFSGPHNksrikdgyplHAPEAYIPYFKKHNISTVVRLNKKL-------------------------------------------------YDAQ
. ||.|. || .          .  | .  .  ..|....|.|.|                                                   .| .
krkfIatqgPlp..........ntvedFWrmvweqnvrvIvmltklvelgrekcaqYwplggsltygditvtllseevlddytvrtlevtnldlldgdge

RFTDHGIEHYDLFfiDGSVPS-DMIVRRFLTIAENA----KGGIAIHCKAGLGRTGTLIACYLM-----KHYRFTAAESIGWLRVCRPGSIIGPQQ
 .| . . ...    | .||.    . .|| .. .|    .| ...||.||.|||||.||..|.     |...... | . .|| .|||... |.|
srtvthfhytnwp..dhgvpdspellldflrlvrkalasgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtpeq
0051429 (Phosphotyrosine protein) phosphatases II 202-320 3.3e-19 65.1 In-house 28-213 (272) alignment 
Range on Protein: 202-320
Range on HMM: 28-213/272.0
GYPLHAPEAYIPYFKKHNISTVVRLNKKLYDAQ---RFTDHGIEHYDLFFIDGSVPSD------------------------------------------
|.||.. .| ....|...|.|.| | .  . ..    .  .||... | ..| |.|.                                           
ggplpltaadfwrlkelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseellldyilrellltlllsagearevmhlhy

----------MIVRRFLTIAENaKGGIAIHCKAGLGRTGTLIACYLMKhYRFT--------------AAESIGWLRVCRPGSIIGPQQ
            ....| .  . .| . .||.|| .||||..|..|.  ....              ..| . .|| .|||..  ..|
tdwpdhgvpqeallellellld.ggpvlvHCsaGkdRTGtvvalllll.lgvsletivddYlltnlyleeaveelraqrpgavqteeq
0036941 (Phosphotyrosine protein) phosphatases II 211-320 3.6e-18 61.3 In-house 70-265 (297) alignment 
Range on Protein: 211-320
Range on HMM: 70-265/297.0
YIPYFK------------------------KHNISTVVRLNKKLYD---------------------------------AQRFTDHGIEHYD--------
|.. ..                        ..|....| |..   .                                  . .| . .| .|        
yvdgydlkrkfIatqgPlpntvedFWrmvweqnvtvIvmltelvelgrekcaqywpleegesltygdftvtllsvevvllddytlrtlevtdtgngesrt

------LFFIDGSVPS-DMIVRRFLTIAEN------AKGGIAIHCKAGLGRTGTLIACYLM--------KHYRFTAAESIGWLRVCRPGSIIGPQQ
      .   | .||.   .. .|.  ...       .| . .||.||.||.||.||..||        |.....  | . .|| .|||..  ..|
vthfhytgwpdhgvpespaslldfielvrkvlkllpsggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleq
subfamily_PTPDC1_pd Subfamily PTPDC1 231-320 3.2e-17 57.5 In-house 73-164 (182) alignment 
Range on Protein: 231-320
Range on HMM: 73-164/182.0
YDAQRFTDHGIEHYDLFFIDGSVPSDMIVRRFLTIAENA--KGGIAIHCKAGLGRTGTLIACYLMKHYRFTAAESIGWLRVCRPGSIIGPQQ
|| . ....|| .| . . | .|.|   .     ... |  .| .|.|| ||||||| ||||||. . |.||...|  .|  || ||   .|
YdlealmeqgiyvynfgwkDygvasleriLdivkvvafalqegkvavhChaGlGrtGvliacylvyakrltaekaiklvrskrpksiqtreq
PTPc_motif_SM00404 213-325 3.6e-15 51.1 In-house 21-133 (140) alignment 
Range on Protein: 213-325
Range on HMM: 21-133/140.0
PYFKKHNISTVVRLNKKL---YDAQRFTDHGIEhYDLFFIDGSVPSDMIVRRFLTIAENAKGGIAIHCKAGLGRTGTLIACYLMKHYRFTAAESIGWLRV
.  ||..|..|. . ..    .  ..|.   |.  |    |  ..    | .|.  ||. .| . .||.||. |..|||..|||. . ...||..  ...
allkklgithvinvteevsltkensgfqilqip.lddnekdklskyldkvldfienaekkggkvlVHCqaGvSRSatliiaYlmryrqlslaeayefvke

CRpgSIIGPQQNFCEE
 |  .|| |. || ..
rR..piispnlnfvrq
subfamily_DSP23_pd Subfamily DSP23 253-320 3.9e-15 50.8 In-house 64-134 (148) alignment 
Range on Protein: 253-320
Range on HMM: 64-134/148.0
VPSDMIVRRFLTIAENAK---GGIAIHCKAGLGRTGTLIACYLMKHYRFTAAESIGWLRVCRPGSIIGPQQ
 |.   | .|. . |.|.     ...||  | |||||..||||.|. ...|||.|  .|  ||||.   .|
ppaleqvvefvrvveeaeekneavsvhcllgrgrtgtmlacylvkerklaaaeaiaevrrlrpgsvetveq
DSPc Dual specificity phosphatase, catalytic domain 258-323 3.9e-14 47.7 Pfam-A 61-124 (133) alignment 
Range on Protein: 258-323
Range on HMM: 61-124/133.0
IVRRFLTIAENAKGGIAIHCKAGLGRTGTLIACYLMKHYRFTAAESIGWLRVCRpgSIIGPQQNFC
 . .|.  ||. .. ...||.||. |..|||..|||| ..... | .  ..  |  |.| |. .| 
eavefiekaeqkgkkvlVHCqaGisRSatliiaYlmktknlslneAyefvkerr..skispnagfl
DSPc Dual specificity phosphatase, catalytic domain 258-323 3.9e-14 47.7 In-house 61-124 (133) alignment 
Range on Protein: 258-323
Range on HMM: 61-124/133.0
IVRRFLTIAENAKGGIAIHCKAGLGRTGTLIACYLMKHYRFTAAESIGWLRVCRpgSIIGPQQNFC
 . .|.  ||. .. ...||.||. |..|||..|||| ..... | .  ..  |  |.| |. .| 
eavefiekaeqkgkkvlVHCqaGisRSatliiaYlmktknlslneAyefvkerr..skispnagfl
subfamily_PTPMT1_pd Subfamily PTPMT1 215-313 1e-12 42.8 In-house 42-150 (171) alignment 
Range on Protein: 215-313
Range on HMM: 42-150/171.0
FKKHNISTVVRLNKKLY------DAQRFTDHGIEHYDLFFIDGS--VPSDMIVRRFLTIAENAKG--GIAIHCKAGLGRTGTLIACYLMKHYRFTAAESI
..|.|. .|| ||.           .... .|.|.. |  .|    .  . . .    | . |.    . .||||| ||..||.||||||.....  | .
iekenvkavvslneeyelkalansteewkklgveqlqlatvDfteapdleklekgvefiekvaskgkrvYvHCkaGrgRsatlvacylmkkeklspeeAl

GWLRVCRPG
  |. .|. 
kalkkkRki
subfamily_RNGTT_pd Subfamily RNGTT 183-316 1.3e-12 41.8 In-house 14-159 (189) alignment 
Range on Protein: 183-316
Range on HMM: 14-159/189.0
VPGKFLAFSGPHNK---SRIKDGYpLHAPEAYIPYFK--KHNISTVVRLNK--KLYDAQRFTDHGIEHYDLFFI-DGSVPSDMIVRRFLTIAEN-----A
. .|||.|  |  |   . .      . |.  . |.|  |...  |. | .  . ||.. ....||..  |     |  |.   |..| .. |.     .
iaekflpfktplskrydddlaeen.rfepsmllsylktlkvklglvidltntsryYdkeelekegikyvklqcagkgeaPeaeqvkefiklveeffkknp

KGGIAIHCKAGLGRTGTLIACYLMKHYRFTAAESIGWLRVCRPGSII
.  |..||. |  ||| ||..||...  . . ...   . .||  | 
eevigvhCthGfnRtGFlivsyLvekedwsveaavalFakaRppGiy
subfamily_DSP11_pd Subfamily DSP11 228-312 1.1e-10 35.7 In-house 67-158 (178) alignment 
Range on Protein: 228-312
Range on HMM: 67-158/178.0
KKLYDAQRFTDHGIEHYDLFFIDGSVPSDMIVRRFLTI-------AENAKGGIAIHCKAGLGRTGTLIACYLMKHYRFTAAESIGWLRVCRP
.. |. . .||.|.... |.    .||.. .|..|           .. .  |..||  |. ||| ||  ||...  . . ..|  .  .| 
dryykkkeltdegvkylklncpGhevpkeelvkkfkeavkefleknkdndkligvhCthGvnrtGyliCrylidvegyepedaieafeearG
subfamily_PTEN_pd Subfamily PTEN 229-302 3.4e-10 35.2 In-house 71-146 (184) alignment 
Range on Protein: 229-302
Range on HMM: 71-146/184.0
KLYDAQRFtDHGIEHYDlfFIDGSVPSDMIVRRFLT-----IAENAKGGIAIHCKAGLGRTGTLIACYLMKHYRFTAAE
. ||...| |. . .|.  | |   |.  .......     ..|. |  ...||||| ||||.||..||.|.  .. ||
rkydskkf.dgrvavyp..fdDhnppplelleeivediekwleedkknvvvvHCkaGkGRtGvlivayllkslllekae
subfamily_DSP1_pd Subfamily DSP1 259-324 1e-09 32.7 In-house 84-147 (163) alignment 
Range on Protein: 259-324
Range on HMM: 84-147/163.0
VRRFLTIAENAKGGIAIHCKAGLGRTGTLIACYLMKHYRFTAAESIGWLRVCRpgSIIGPQQNFCE
|  |.  .....| . |||.||. |  ||.  ||||. |..  |   . .  |  ||| |  .|  
viefidevkkknGkvlihCqaGisRsstlclaylmktkrvsleeafdfvkqrR..siisPnagFvl
subfamily_DSP10_pd Subfamily DSP10 264-323 2.3e-09 31.3 In-house 86-143 (159) alignment 
Range on Protein: 264-323
Range on HMM: 86-143/159.0
TIAENAKGGIAIHCKAGLGRTGTLIACYLMKHYRFTAAESIGWLRVCRPgsIIGPQQNFC
  | .    . .||.||. |  |..  ||||| . .  ..  . ...||  || |  || 
eearkkgsrvLvhCqaGisrsatvviaYlmkhlnlslndaykfvkekrp..iisPnLnfm
subfamily_DSP3_pd Subfamily DSP3 224-322 4.2e-09 30.3 In-house 51-146 (162) alignment 
Range on Protein: 224-322
Range on HMM: 51-146/162.0
VRLNKKLYDAQRFTDHGIEHYDLFFIDGSVPSDMIVRrFLTIA-ENAKGGIAIHCKAGLGRTGTLIACYLMKHYRFTAAESIGWLRVCRPgsiIGPQQNF
|  ... |.   .. .|.|  | . .| |.  .  .. |.  | .. .| . .||..|. |  ||.  ||| . ..|. | |   |  |    |.| . |
vdtgaefykdleikylGlevdDvpefdlskyFetaak.fidealsqkegkvlvhcvvGvsRsatlvlayLmirrkmtlveairtvrkkRe...ilPneGF
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 232-315 5e-09 30.2 In-house 176-266 (290) alignment 
Range on Protein: 232-315
Range on HMM: 176-266/290.0
DAQRFTDHGIEHYDLF-FIDGSVP-SDMIVRRFLTIAENAKGGIAIHCKAGLGRTGTLIAC-----YLMKHYRFTAAESIGWLRVCRPGSI
| .   .| . |. .  . | ||. |.. . | | |  .| | ...|| ||.|||||..|       |..   .  .. .  || .| .|.
dkdsGkehklkhlkikswpdksvalstlallrtlrilrkasGpvvvhcsaGiGrtGtfvaievglqilldGkeldlldlvralrnsrlnsv
subfamily_DSP19_pd Subfamily DSP19 261-324 8.1e-09 30.0 In-house 80-141 (152) alignment 
Range on Protein: 261-324
Range on HMM: 80-141/152.0
RFLTIAENAKGGIAIHCKAGLGRTGTLIACYLMKHYRFTAAESIGWLRVCRPGsiIGPQQNFCE
 |.  | ...| . .||.||  |. ...  ||||. . .  |..  .|  ||   | | . |..
dFieearskdgavlvHCnAGvSRsasvviaylmkkeelsleealelvrearpc..ikPneGFik
subfamily_DSP12_pd Subfamily DSP12 261-324 1.7e-08 29.0 In-house 73-134 (155) alignment 
Range on Protein: 261-324
Range on HMM: 73-134/155.0
RFLTIAENAKGGIAIHCKAGLGRTGTLIACYLMKHYRFTAAESIGWLRVCRPgsIIGPQQNFCE
.|.  | . .| . .||.||. |  |... ||||....   . .  ..  .|   | | ..| |
dFieealeeegavlvHCqagvSRSvtiviAYlmkkeklslekAlklvkekkp..eiepNegFle
subfamily_Dicty-DSP19-like_pd Subfamily Dicty-DSP19-like 268-325 3.6e-08 26.9 In-house 89-144 (154) alignment 
Range on Protein: 268-325
Range on HMM: 89-144/154.0
NAKGGIAIHCKAGLGRTGTLIACYLMKHYRFTAAESIGWLRVCRPgsIIGPQQNFCEE
  .... .|...|. |. .|.  |||.. . .  ...  |. .|.  || | | | . 
vennkvlvhsdkGvsrsaallisylmdklkislslalellkdsry..iikPnqGflkq
subfamily_Slingshot_pd Subfamily Slingshot 261-326 6.4e-08 26.2 In-house 87-150 (169) alignment 
Range on Protein: 261-326
Range on HMM: 87-150/169.0
RFLTIAENAKGGIAIHCKAGLGRTGTLIACYLMKHYRFTAAESIGWLRVCRpgSIIGPQQNFCEEK
.|.. | ...  . .||| |. |. . .  | ||.|...  |.. ...  |  |.| | ..| .  
kfiekakkkgskvlvhckmGvsrsastviayamkeyglsleealeyvkerr..svikPnkgflkql
PTPc_DSPc_SM00012 262-295 6.8e-08 28.0 In-house 32-64 (105) alignment 
Range on Protein: 262-295
Range on HMM: 32-64/105.0
FLTIAENaKGGIAIHCKAGLGRTGTLIACYLMKH
. . .|. .. . .||.|| |||||..| ... .
nknkses.skpvvVhCsaGvgRtgtfvaldillq
subfamily_DSP14_pd Subfamily DSP14 266-323 1.2e-07 25.8 In-house 79-134 (157) alignment 
Range on Protein: 266-323
Range on HMM: 79-134/157.0
AENAKGGIAIHCKAGLGRTGTLIACYLMKHYRFTAAESIGWLRVCRPgsIIGPQQNFC
.....| . .||.||  |  .|   ||||. . . .|.  ... .||  || | . | 
vkkkggktlvhCvaGvSRSAslclaylmkyeklsLreayklvksaRp..iirPNvGFw
subfamily_LRR-DSP_pd Subfamily LRR-DSP 269-322 1.5e-07 24.8 In-house 196-247 (263) alignment 
Range on Protein: 269-322
Range on HMM: 196-247/263.0
AKGGIAIHCKAGLGRTGTLIACYLMKHYRFTAAESIGWLRVCRPgsIIGPQQNF
 |||. .||.||. |. ||. .||||. |..  |..      ||   | | . |
kkGGvlvhcraGvsrsstlvisylmkkqrlkfkealdlvikkrp..riqPnpGf
0048567 (Phosphotyrosine protein) phosphatases II 174-227 2.2e-07 25.4 In-house 2-60 (157) alignment 
Range on Protein: 174-227
Range on HMM: 2-60/157.0
VENGDFNWIVPGKFLAFSGPHNKSRIKDGYPLHAPE--AYIPYFKKH---NISTVVRLN
.||||...|.|........|. .... . .... ..   |...| ..   |.....|..
kengdlieiipdrlyfallprlpkslynalyFsiddglvyedfffdfGPlnlailyrFi
subfamily_DSP8_pd Subfamily DSP8 262-324 4.5e-07 23.5 In-house 85-145 (159) alignment 
Range on Protein: 262-324
Range on HMM: 85-145/159.0
FLTIAENAKGGIAIHCKAGLGRTGTLIACYLMKHYRFTAAESIGWLRVCRpgSIIGPQQNFCE
|.  | ...| . .|. ||  |  |.. .|.||. ...  |.  ...  |    | |. || .
fidkaksengrvlvhvlaGisrsatvaiayimktlemsldeayrfvkekr..ptispnlnflg
subfamily_DSP6_pd Subfamily DSP6 261-323 4.7e-07 23.5 In-house 84-144 (158) alignment 
Range on Protein: 261-323
Range on HMM: 84-144/158.0
RFLTIAENAKGGIAIHCKAGLGRTGTLIACYLMKHYRFTAAESIGWLRVCRpgSIIGPQQNFC
.|.  | ..| .. .|| ||. |. |.. .||||.. ..  ..  ...  .  | | |  || 
efidearskkskvlvhClaGisrsvtvtlaylmkklalslndaydlvkkrk..snisPnfnfm
subfamily_VSP_pd Subfamily VSP 266-304 6e-07 23.6 In-house 124-163 (212) alignment 
Range on Protein: 266-304
Range on HMM: 124-163/212.0
AENAKGGIAIHCKAGLGRTGTLIACYLMKHYRFTAAE-SI
... |  .||||| | |||||.. ..|..   |. |. |.
ekdlknvlaihckGGkgrtGtivcalllaseifetakesl
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 250-293 8.1e-07 23.0 In-house 198-243 (305) alignment 
Range on Protein: 250-293
Range on HMM: 198-243/305.0
DGSV-PSDMIVRRFLTIAENAKGGIAIHCKAGLGRTGTLIAC-YLM
|  | ..|. .  .|. |  .|| |..|| ||.||||...   |..
drgvpaadlailellekarpskgpivvhcsagigrtgsvvmleyil
subfamily_MSG5_pd Subfamily MSG5 261-304 2.3e-06 20.8 In-house 90-133 (165) alignment 
Range on Protein: 261-304
Range on HMM: 90-133/165.0
RFLTIAENAKGGIAIHCKAGLGRTGTLIACYLMKHYRFTAAESI
| .  |.  .  | .||. || |. .||  |.||.| ..  .. 
riihaatskrkkilvhcqcglsrsaslivayimkyynlslrday
subfamily_DSP15_pd Subfamily DSP15 216-319 2.9e-06 21.5 In-house 24-125 (151) alignment 
Range on Protein: 216-319
Range on HMM: 24-125/151.0
KKHNISTVVRLNKklyDAQRFTDHgiEHYDLFFIDGSVPSDMI-----VRRFLTIAENAKGGIAIHCKAGLGRTGTLIACYLMKHYRFTAAESIGWLRVC
|..||.... ..    .|... ..   .| .. .. .   ..        .|.  .   .... .|| ||. |  ||.. |||    .   ...  .. .
keknithilsvhd...nakkllkd..ieYkciaasDtpsaklskffkesvefihkcRlkeenvlvhClaGvsRsvtlvvaYlmtvtelnwrdalevikaa

RpgSIIGPQ
|  |.  | 
R..svanPn
subfamily_Dicty-DSP-Subfam1_pd Subfamily Dicty-DSP-Subfam1 230-306 3.2e-06 19.9 In-house 22-102 (128) alignment 
Range on Protein: 230-306
Range on HMM: 22-102/128.0
LYDAQRFTDHGIEHYDLFFID---GSVPSDMIVRRFLTIAENAK-GGIAIHCKAGLGRTGTLIACYLMKHYRFTAAESIGW
|.| .   .. ...| | . |     .|  .   | .  .|.     . .||. |  ||| ..| | ||.  .   ... |
lidpnllpeddlkeyaltlsdwsadklpyrirdyrnillserelplvlyvhcecgcdrtgevlasyvmkykgydlkkalew
subfamily_Dicty-DSP19-1_pd Subfamily Dicty-DSP19-1 230-306 3.5e-06 19.8 In-house 21-101 (128) alignment 
Range on Protein: 230-306
Range on HMM: 21-101/128.0
LYDAQRFTDHGIEHYDLFFID---GSVPSDMIVRRFLTIAENAK-GGIAIHCKAGLGRTGTLIACYLMKHYRFTAAESIGW
|.| .   .. ...| | . |     .|  .   | .  .|.     . .||. |  ||| ..| | ||.  .   ... |
lidpnllpeddlkeyaltlsdwsadklpyrirdyrnillserelplvlyvhcecgcdrtgevlasyvmkykgydlkkalew
subfamily_PTPN13_pd Subfamily PTPN13 250-293 5e-06 21.0 In-house 178-225 (273) alignment 
Range on Protein: 250-293
Range on HMM: 178-225/273.0
DGSVPSD---M--IVRRFLTIAEnAKGGIAIHCKAGLGRTGTLIACYLM
| .|||    .  .|..  ....  .| |..|| ||.||.||||. . .
dhgvPssaaellqfvaevrrlqt.dagPivvhcsaGiGrsGtlitidvv
Y_phosphatase Protein-tyrosine phosphatase 258-293 5.8e-06 21.3 Pfam-A 156-193 (235) alignment 
Range on Protein: 258-293
Range on HMM: 156-193/235.0
IvrRFLTIAENAK----GGIAIHCKAGLGRTGTLIACYLM
.  ....  |. |    | . .||.|| |||||..|  ..
l..dlirkvekskeaksgpvvVhCsaGvgRtgtfvaldil
Y_phosphatase Protein-tyrosine phosphatase 258-293 5.8e-06 21.3 In-house 156-193 (235) alignment 
Range on Protein: 258-293
Range on HMM: 156-193/235.0
IvrRFLTIAENAK----GGIAIHCKAGLGRTGTLIACYLM
.  ....  |. |    | . .||.|| |||||..|  ..
l..dlirkvekskeaksgpvvVhCsaGvgRtgtfvaldil
subfamily_CDKN3_pd Subfamily CDKN3 234-294 8.6e-06 19.5 In-house 93-156 (202) alignment 
Range on Protein: 234-294
Range on HMM: 93-156/202.0
QRFTDHGIEHYDLFFIDGSVPSDM---IVRRFLTIAENAKGGIAIHCKAGLGRTGTLIACYLMK
. ..  |.  .   . || ||.      .   |.|. .|  .  .||  ||||.  .||| |. 
dlyqqaglivhhypiadglvpdiasclkileelrinlkayrktlvhcygglgrsslviacllly
subfamily_STYXL1_pd Subfamily STYXL1 261-324 9.9e-06 18.8 In-house 83-144 (157) alignment 
Range on Protein: 261-324
Range on HMM: 83-144/157.0
RFLTIAENAKGGIAIHCKAGLGRTGTLIACYLMKHYRFTAAESIGWLRVCRPGsiIGPQQNFCE
.|. . .. .  . .  . |. |. ..|..||| ....|  ..   |. |..   . |...| |
qfiekhkkegevvlvfsnkGisrsaaviiaylmyskkitlkkaykylkkCken..vkPnrafve