Gene CDC14-2 in Nematostella vectensis

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family DSP
Subfamily CDC14
Protein sequence
ID Type Fasta BLAST phosphatome Note
NvecP003_AA protein Get Run
NvecP003_AA_6-164 phosphatase_domain Get Run
NvecP003_AA_181-341 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_CDC14_pd Subfamily CDC14 8-339 2.1e-136 449.1 In-house 2-323 (328) alignment 
Range on Protein: 8-339
Range on HMM: 2-323/328.0
SSCELVEDRLFFVTVACKPRNSPSFHYFGVDHDWTLDgcKLFDTpyFGPSNLAGIYRFCCLVNTKLHMVP-ASKKIVMYTTAEddlesTKKRTRAIFLCG
...||.||||.|.|...||......|||.||......  .....  |||.||| .||.|. .|.||...  ||||||.||.|.     .|||..|..|.|
nalelledrlyfatlrkkPkstselhyfsvddelkye..nfyad..fGPlnlavlyrycvklnkkLkseekaskkivlytsad.....skkranaallig

AFAVCQLNMSAEEAYQAMERQFRPNSVMFYCDINGNKSHDLNILDCLKGFEKAISRGFFSFEDFDLNRYEEDEKAF--DSNWIVPGKILAMSDPQRRNEv
|.||..|...|||||.|.|.. .|..|.|.....|..|..|..||.|||.|||...||...|||||..||..|...  |.|||||.|.||...|..... 
ayaviylkktaeeayraleaaetppfvpfrdasygsasykltlldvlkgvekalqkgfldledfdleeYekyervenGDfnwivPdkflalagPhnksk.

KASRF-----AKLRKHFRQNGVKTVVRLNRDdnmikyglVYDARCFTANGFAHSDQYFEDGGIPTKAIVKRFTRILDHCEGAVAIHCRAGLGRTGTLIAC
.....     .|| ..||.|.|.||||||..        .|||..||..||.|.|..|.||..|..||||.|..|....|||.|.||.||||||||||||
ledgyplhaPeklleyfrknnvttvvrLnkk........lYdakkftdaGfdhkDlffiDGstPsdaivkkfleiaekaeGaiavhCkaGLGrtGtLiac

YLIKQYKFSAAEAVGWLRICRPGSVSSLQHCFLEHKQEAI
||.|.|.|.||||..||||||||||.. |..|||.||.|.
ylmkhyrftaaeaiawlricrPGsvigpqqkfleekqaal
DSPn Dual specificity protein phosphatase, N-terminal half 10-159 6.1e-48 153.1 Pfam-A 1-141 (141) alignment 
Range on Protein: 10-159
Range on HMM: 1-141/141.0
CELVEDRLFFVTVACKPRNSPSFHYFGVDHDWTLDGCklfdTPYFGPSNLAGIYRFCCLVNTKLHMVPASKKIVMYTTAEDDlestKKRTRAIFLCGAFA
.||.||||.||....||......||| .|.... ...    . .||| ||| |||||. .|.||... ..|| ....|..|.    |||..|..|.||.|
ieliedrLyfvslkkkpkktenthyfsiDeelvYepf....yadFGPlnlaqiyrfcvklnkkLkeaelkkkkivlytslde....kkranaalLigaYa

VCQLNMSAEEAYQAMERQFrpNSVMFYCD-INGNKSHDLNILDCLKGFEKA
|..|..|.|||....|..   .|.....| ..|.....|.|||||||.|||
vivlklspeealkplesve..psllpFrDAsygestyeltildclkglekA
0048567 (Phosphotyrosine protein) phosphatases II 6-168 3.3e-35 115.6 In-house 4-157 (157) alignment 
Range on Protein: 6-168
Range on HMM: 4-157/157.0
VMSSCELVEDRLFFVTVACKPRNSPSFHYFGVDHDwtldgcKLFDTPY--FGPSNLAGIYRFCCLVNTKLHMVP-ASKKIVMYTTAEDdlestKKRTRAI
... .|...|||.|...  .|.. ....|| .|..       .. ...  ||| ||| .|||....| .|...  |.|.|.....|       |||.|. 
ngdlieiipdrlyfallprlpkslynalyFsiddg......lvyedfffdfGPlnlailyrFilklnkflkilelagkaiavhckagl.....kkrgrta

FLCGAFAVCQLNMSAEEAYQAMeRQFRPNSVMFYCDINGNKSHDLNILDCLKGFEKAISRGFFSFE
.|.|..... |....|||.. . |..||.||.|.   ...  ..|..||.|.|..||...||...|
tLigcYlilhlgftpeeaiapl.rivrpgsvpfrdasyllslynltlldvlyGllkAlelgfldle
0038934 (Phosphotyrosine protein) phosphatases II 184-326 6.5e-33 109.4 In-house 12-162 (194) alignment 
Range on Protein: 184-326
Range on HMM: 12-162/194.0
SNWIVPGKILAMSDPQRRNevkasrFAKLRKHFRQNGVKTVVRLNRD---DNMIKY-----GLVYDARCFTANGFAHSDQYFED-GGIPTKAIVKRFTRI
 ..|..|...|.. |   .      . |  . . .......||. ..   ..   .     . .||.. |...|. . . .|.| | .|. .|..|| ..
vgdiitgrfiafkvPlsgs......ldkyieelyrfspedlvrylkllnvklglvidltnteryYdpeefekagieylklpfpddgtvPsleillrfldl

LDH-----CEGAVAIHCRAGLGRTGTLIACYLIKQYKFSAAEAVGWLRICRPGSVSS
.|.      .|.||.|| |||||||||.|.|||. ...|| ||....|..|||.. .
vdeflnedpggvvaVHCkaGlgRtGtlvaaYLiyrlgmsaeeAialfrekRpgaipn
PTEN_1 183-341 1.3e-32 108.2 In-house 24-193 (196) alignment 
Range on Protein: 183-341
Range on HMM: 24-193/196.0
DSNWIVPGKILAMSDP------QRRNEVKASRFAKLRKHFRQNGVKTVVRLNRDDNMikYGLVYDARCFTANGFAHSDQYFEDGGIPTKAIVKRFTRILD
 ... . ..  |.|.|      .....  ..  |...... ..|. .||.|. ....  .|  || . | ..|. . .  .|| | |. . . .. . ..
yitsriiamgkapsrpllqeideglyrgslkdvaadldnlkedgitlvvnlseeeel..sgrsydleeffksgveylhfpieDhgapslselfdicksfi

HC------EGAVAIHCRAGLGRTGTLIACYLIKQYKFSAAEAVGWLRICR-PGSVSSLQHCFLEHKQEAIQR
..      ...|..||.|||||.||..|.||.. .|..| ||. ..|..| ||.. | ..  |.. .. ...
ewllsdpngnvVlVHCkaGlgRsGtvvaayLmykgkltadeAlelvrekRppgapnspsqerlleyfaella
0048567 (Phosphotyrosine protein) phosphatases II 182-339 2e-31 103.4 In-house 5-149 (157) alignment 
Range on Protein: 182-339
Range on HMM: 5-149/157.0
FDSNWIVPGKILAMSDPQRRNevkasrfaklrkhfrqngvktvvrlnrddnmikygLVYDARCF-TANGFAHSDQYFEDGgiPTK--------AIVKRFT
.| ..|.|....... |. ..                                    .|.| .| . .|. . | .|..|  | .         ....| 
gdlieiipdrlyfallprlpk...................................slynalyFsiddglvyedfffdfG..PlnlailyrFilklnkfl

RILDHCEGAVAIHCRAGL---GRTGTLIACYLIKQYKFSAAEAVGWLRICRPGSVSSLQHCFLEHKQE------------AI
.||.....|.|.|| |||   |||.|||.||||. ..|...||...|||.|||||   ....|.....            |.
kilelagkaiavhckaglkkrgrtatLigcYlilhlgftpeeaiaplrivrpgsvpfrdasyllslynltlldvlyGllkAl
0041856 (Phosphotyrosine protein) phosphatases II 170-339 4.3e-31 103.3 In-house 2-169 (182) alignment 
Range on Protein: 170-339
Range on HMM: 2-169/182.0
FDLNRYEE---DEKAFDSNWIVPGkILAMSDPQRRNEVK----ASRFAKLRKHFRQNGVKTVVRLNrddnmikyGLVYDARCFTANGFAHSDQYFEDGGI
.|.|||..    .   |...| .. ....| |..| ..      | .|.  . ....|..|.|.|.        .  |..  .. .|. . .  ..|.|.
ldknrysdilpydhsrdldyInan.lylgslpatrfiatqgpllstvadflrmlkelgittivnlt........eelywpellerlgiqylylpwpDhgv

PTKAIVKRFTRILDHCEGAVAIHCRAGLGRTGTLIACYLIKQYKFSAAEAVGWLRICRPGSVSSLQHCFLEHKQEAI
|.  .. .| ..  . .|.|..||.||.||||||.|.||.|....|. ||| ..| .|||.| .... |... ..  
pdldelldfieevleeggpvlVHCsaGvgRtgtlvaaylmkklgvsleeavklvrsrRpgmvitpnqyfflqlalle
0046846 (Phosphotyrosine protein) phosphatases II 175-331 7.2e-31 102.7 In-house 3-164 (176) alignment 
Range on Protein: 175-331
Range on HMM: 3-164/176.0
YEEDEKAFDSNWIVPGkILAMSDPQRRNEVKASRFAKLRKHFRQNGVKTVVRLNRDDNMIKYGLVYDARCFTANGFAHSDQYFEDGGIPTKAIVKRFTRI
. ..   .|...|... ....| |    .   . .|.  ......|...||.|. .  . .... ..   ....|. .    ..|.|.|. ... .. ..
lrllgldldldyinan.lilgsrpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgiqylhlpwpDhgvpdlelllellef

LDHCE---GAVAIHCRAGLGRTGTLIACYLIKQ-YKFSAAEAVGWLRICRP-GSV-SSLQHCF
.. .    | |..||.||.||||||.|.||..  . .|. ||. ..| .|| |.| .  |  |
irealkeggpvlVHCsaGigRtgtlvaayllelekglsveealalvreqRplgavqtpeQyrf
0043147 (Phosphotyrosine protein) phosphatases II 186-336 2.2e-29 97.8 In-house 16-156 (172) alignment 
Range on Protein: 186-336
Range on HMM: 16-156/172.0
WIVPGKILAMSDPqrrnevKASRFAKLRKHFRQNGVKTVVRLNRDdnmikyglVYDARCFTANGFAHSDQYFEDGGIPTKAIVKRFTRILDH-----CEG
...| ...|.  |        . .|. .. ....|....|.|..         .||. ... .|. .   ...|.| |. ... .| ...|.      .|
yyipdrfiatqgp......lrntladfwrmlkelgithivnltel........lydpellerlgiqylylpwpDhgvpllellleflefidellalspgg

AVAIHCRAGLGRTGTLIACYLIKqYKFSAAEAVGWLRICRPGSVSSLQHCFLEHKQ
.|..||.||.||||||.|.||.. ...|. ||| ..| .|||.| . ..  . .. 
pvlVHCsaGvgRtgtlvaaylml.lglsleeavalvrekRpgavqnpsqyrflyyf
0050432 (Phosphotyrosine protein) phosphatases II 127-331 4e-29 97.3 In-house 6-289 (308) alignment 
Range on Protein: 127-331
Range on HMM: 6-289/308.0
QFRPNSVMFYCDINGNKSHDLNILDCLKGFEKAISRGFFSFEDFDLNRYEEDEKAFDSNW---------------------------------------I
.. .. ..|. .   ..|..|..||.|| .|||...|... | ..|... .... . ...                                       .
dallelllfrdtsilvsslklsvldllkllekaldlglleeefeellsvkplleysvallpenkdkNrykdilpydhsRVkldegsdYInAsyvdgyssk

VPGKILAMSDPQrrnevkASRFAKLRKHFRQNGVKTVVRLNRDDNmikYGLVYDARCFTAN---GFAHSDQYF---------------------------
.| |..|.  |        . ...  . . ...|...|.|.. ..   .| .  |. .  .   |. . ....                           
lprkfIatqgPl......pntvedFwrmvweqnvrvIvmLtklve...ngrekcaqYwplelgggsleygkftvtllseevlddytvrtleltnlgdges

-----------EDGGIPTK-AIVKRFTRILDHC--EGAVAIHCRAGLGRTGTLIACYLI-----KQYKFSAAEAVGWLRICRPGSVSSLQHCF
           .|.|.|.. .|. .| ......  .| ...||.||.|||||.||..|.     |...... ||| .|| .|||.| .... .
rtvthfhytnWpdhgvPpspeilldflelvrkslpggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtpeqyl
0044763 (Phosphotyrosine protein) phosphatases II 172-336 6e-29 96.3 In-house 11-167 (178) alignment 
Range on Protein: 172-336
Range on HMM: 11-167/178.0
LNRYEEDEKAFDSNWIVPGkILAMSDPQrrnevkasrfAKLRKHFRQNGVKTVVRLNRDDNMIKYGlvYDARCFTANGFAHSDQYFEDGGIPT-KAIVKR
  ...|    .. ..|.|| ....| |.          |. .. ....|....|.|. .. . ...  .|.  .. .|. .    ..|.| |.  ... .
nleglersdyinaseilpg.lylgslpp..........addlellkelgithivnlteelelgflk..cdpywpeeagiqylhipipDhgvpdllehfle

FTRILD----HCEGAVAIHCRAGLGRTGTLIACYLIKQYKFSAAEAVGWLRICRPGSVSSLQHCFLEHKQ
|.....     ..|.|..||.||.||.|||.|.||.|....|. ||. ..| .||.. .  |  .|.  .
fvefieealdekggpvlVHCsaGvgRsgtlvaaylmkklglsleeaielvrerRpivpnpgqlrqLyefe
0039614 (Phosphotyrosine protein) phosphatases II 141-329 1.1e-28 96.1 In-house 10-277 (297) alignment 
Range on Protein: 141-329
Range on HMM: 10-277/297.0
GNKSHDLNILDCLKGFEKAISRGFFSFEDFDLNRYE--------------------------------EDEKAFDSNWI----------VPGKILAMSDP
.. .  |..||.|...||| |....  | ..| ..                                 ||.  .||..|          .. |..|.. |
esipiplsvldlllllekansktllllefeellslkpdysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfIatqgP

QRRnevkasRFAKLRKHFRQNGVKTVVRLNRDDNM---------IKYGlVYDARCFTANGFAHSDQYF-----------------------EDGGIP-TK
.         ...  . ....||...|.|.. . .          . | .|.  . |  .. | | |.                        |.|.| . 
lpe......tvedFwrmvweqgvtvivmLtklvelgrkcaqywpeegg.tygdftvtllkvehldgytvrtlevtnngesrtvthfqytgwpdhgvppsl

AIVKRFTRILDH------CEGAVAIHCRAGLGRTGTLIACYLI-----KQYKFSAAEAVGWLRICRPGSVSSLQH
... .| .....       .| |..|| ||.|||||.||.||.     | ..... ||| .|| .|||.| ....
ellleflelvrealaelpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsq
0049772 (Phosphotyrosine protein) phosphatases II 136-335 1.5e-28 95.9 In-house 74-274 (314) alignment 
Range on Protein: 136-335
Range on HMM: 74-274/314.0
YCDINGNKSHdlniLDCLKGfEKAISRGFFSFEDFDLNRYEEDEKAF--DSNWIVPGK---------------------ILAMSDPQrrNEVKASRFAKL
|..... ...    |...   ..  . ....|.....  |.  .  .  | |......                     .| .. ..  ||  |.... |
yinasyvdgf....lkfIat.qgpleitvvdfreepvlyyngwrmvlrgdlnvrdivmsrdevladelsrLdaAlgKtpllildgng..neptaadlell

RkhfrqngvktvvrlnrddnmikyGLVYDARCFTANGFAHSDQYFEDGGIPTKAIVKRFTRILDH--CEGAVAIHCRAGLGRTGT-LIACYLIKQYKFSA
.                       . .||.  |. .|. . .  ..||. |. .....| ....    .|.|..||.|| ||||| ..|.||.|....|.
k.......................eelydpelferlgikylripvpDgsaplledfdeflefieeadkggpvlvHCkaGkgRtgtfvvaaylmkllgvsl

AEAVGWLRICRP-----GSVSSLQHCFLEHK
.||. ..| .||     |.. .|..   ...
eealedvrlkRpinpnpgfieqleqyefile
0051082 (Phosphotyrosine protein) phosphatases II 180-335 3.6e-27 90.2 In-house 4-147 (151) alignment 
Range on Protein: 180-335
Range on HMM: 4-147/151.0
KAFDSNWIVPGkILAMSDPqrrnevKAsrfaKLRKHFRQNGVKTVVRLNRDDNMIkyglvYDARCFTANGFAHSDQYFEDGGIPTK----AIVKRFTRIL
. .. ... .| ..... |       |       . ....|.||.| |. .. .      |... ....|. . . ...|   |.     ..|..| ..|
dyinfsyvtgg.lyrsggp......la....dflellkelgiktivnlrseeerg.....ycpeylpelgievlhipildwpdpglplsfdavleflell

DHC-EGAVAIHCRAGLGRTGTLIACYLIKqYKFSAAEAVGWLRICRPGSVSSLQHCFLEHK
... .| |..||.||.||||||.|.||.. ...|..||. ..|..|||.| . |. .....
ldkkngpvlvHCsaGkgRTGtlvalylml.lgvsleealeeyrlkrpgvvqpnqqflfqlf
0040438 (Phosphotyrosine protein) phosphatases II 147-329 1.5e-26 88.8 In-house 7-264 (317) alignment 
Range on Protein: 147-329
Range on HMM: 7-264/317.0
LNILDCLKGFEKAISRGFFSFEDF--------------DLNRY-------------EEDEKAFDSNWI---------VPGKILAMSDPQrrnevkASRFA
| .||.||.  .|....|. . ..              |.|||               ... .||..|          . |..|.. |.       . ..
lalldllksdftalleefedllslkldtysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyvdgpnlkrkfIatqgPl......pntve

KLRKHFRQNGVKTVVRLNRDDNmikyglvydarcftaNGFAHSDQYF--------------------------------------------------EDG
.  . . ..||...|.|.. .                .|   ..||.                                                   |.
dFwrmvweqgvtvivmLtelee...............lgrekcaqYwplgetltygdftvtllseeelagitlrtlevedlgdsesrtvthfhytgWpdh

GIP-TKAIVKRFTRILDHC----EGAVAIHCRAGLGRTGTLIACYLI-----KQYKFSAAEAVGWLRICRPGSVSSLQH
|.| .  .. .| ......    .| |..|| ||.|||||.||.||.     | ..... ||| .|| .|||.| ....
gvppspdllldfleavrealedpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeq
0042113 (Phosphotyrosine protein) phosphatases II 167-329 2.4e-26 88.1 In-house 7-231 (245) alignment 
Range on Protein: 167-329
Range on HMM: 7-231/245.0
FEDFDLNRY-------------EEDEKAFDSNWI---------VPGKILAMSDPQRRnevkasRFAKLRKHFRQNGVKTVVRLNRDDNMIK---------
 |. |.|||              .|.  .||. |         ...|..|.. |..        ...  . ....|..|.|.|.... . .         
penkdknrysdilpydhtrvklspdggdldsdyinasyvdgyritpkfiatqgPlpe......tvedfwrmlwelgittivmLteeeelgrvkcaqywpl

--------------------------YGLVYDARCFTANGFAHSDQYFEDGGIPT-KAIVKRFTRILDH-----CEGAVAIHCRAGLGRTGTLIACYLI-
                          . ....   .. ... .    ..|.|.|.  ... .| .....      .| |..||.||.|||||.||.||. 
gesltygdftvtllseehlddytvrtlevtnlgddesrevihyhylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylml

----KQYKFSAAEAVGWLRICRPGSVSSLQH
    | ...|. ||| .|| .|||.| ....
eqlekelgvsleeavkelrsqRpgavqtpsq
0043336 (Phosphotyrosine protein) phosphatases II 149-329 3.5e-26 87.7 In-house 11-265 (278) alignment 
Range on Protein: 149-329
Range on HMM: 11-265/278.0
ILDCLKGFEKAISRGFFSFEDFDL--------------NRYE-------------EDEKAFDSNWI---------VPGKILAMSDPQRRnevkasRFAKL
.|..|... ......|... .|.|              |||               ... .||..|         || |..|.. |.         ... 
llelllnlktllllefeellsfkldtysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyvdgynvprkfiatqgPlpe......tvedF

RKHFRQNGVKTVVRLNRDDNM------------------------------------IKYGLVYDARCFTANGFAHSDQYfeDGGIP-TKAIVKRFTRIL
.. ....||.|.|.|.... .                                    ..    .|  ..| ... . .    |.|.| . ... .| ...
wrmvwelgvttivmLtelvelgrvkcaqYwpggsltygdftvtllkeehlddytvrtlevtnlgdgesrtvthyhylgwp..dhgvpeslsllldflkav

DH----CEGAVAIHCRAGLGRTGTLIACYLI-----KQYKFSAAEAVGWLRICRPGSVSSLQH
..    ..|.|..||.||.|||||.||.||.     | ..... ||| .|| .|||.| ....
realedsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsq
0049260 (Phosphotyrosine protein) phosphatases II 209-335 4.9e-26 86.6 In-house 22-144 (152) alignment 
Range on Protein: 209-335
Range on HMM: 22-144/152.0
FAKLRKHFRQNGVKTVVRLNRDDNmikyglvyDARCFTANGFAHSDQYFEDGGIPTKAIVKRFTRILDHC-----EGAVAIHCRAGLGRTGTLIACYLIK
.|.  . ....|..|.|.|....         .......... .   ...|.| |. ... .|  .....     .| |..||.||.||||||.|.||..
ladfwrmlkelgittivmltelle........lgklkceqyiqylhlpwpDhgvpdlsqlllflllfieklaldkggpvlVHCsaGvgRtgtlvaaylml

qYKFSAAEAVGWLRICRPGSVSSLQHCFLEHK
 ...|. ||| ..| .|||.| . .. .. ..
.lgvsleeavalvrekRpgavpnpgqlrflye
0040439 (Phosphotyrosine protein) phosphatases II 168-328 1.2e-25 86.1 In-house 10-233 (249) alignment 
Range on Protein: 168-328
Range on HMM: 10-233/249.0
EDFDLNRYE-------------EDEKAFDSNWI---------VPGKILAMSDPQRRnevkasRFAKLRKHFRQNGVKTVVRLNRDDNMIKYGLV------
|. |.|||                .. |.|. |         .. ...|.. |          ... .. ....|....|.|.... . . .        
enkdknrypdilpydhsrvklsilpglflsdyinAsyidgyyikrrfiatqgPlpe......tvedfwrmlwelgitvivmLtslvelgrekcaqywplg

-------------------------------YDARCFTANGFAHSDQYfeDGGIP-TKAIVKRFTRILDH------CEGAVAIHCRAGLGRTGTLIACYL
                               ||   .| ... . |    | |.| . ... .| .....      ..| |..|| ||.|||||.||.||
gsleygdftvtllsvevkddytvrtleltnlydgesrtvlhiqytdwp..dhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaayl

I-----KQYKFSAAEAVGWLRICRPGSVSSLQ
.     | ..... ||| .|| .|||.| ...
mleqlekelgvdleeavkllrsqRpgavqnpe
0045450 (Phosphotyrosine protein) phosphatases II 144-328 2.6e-25 85.2 In-house 17-291 (307) alignment 
Range on Protein: 144-328
Range on HMM: 17-291/307.0
SHDLNILDCLKGFEKAISrGFFSFEDF--------------DLNRYEE-------------------DEKAFDSNWI------------VPGKILAMSDP
   |..||.| |..|..   ..|...|              |.||| .                   |   .. ...            .. |..|.  |
lvllllldfltgllkefe.kllsvtvfllgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydlkrkfIatqgP

QRRnevkasRFAKLRKHFRQNGVKTVVRLNRDDNM----------------------------------IKYGLVYDARCFTANGFAHSDQYF---EDGG
.         ...  . ....||...|.|.... .                                  . . |      .| ... .   ..    |.|
lpe......tvedFwrmlweqgvtvivmltelvelgrekcaqywPdegeeltygnftvtllseehldgytvrtlevtdldgtgesrtvthfhytgwpdhg

IP-TKAIVKRFTRILDH------CEGAVAIHCRAGLGRTGTLIACYLIKQYK--------FSAAEAVGWLRICRPGSVSSLQ
.| . ... .| .....      ..| |..||.||.|||||.||.||....         ... ||| .|| .|||.| ...
vppsfeelldfieevrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpe
0036282 (Phosphotyrosine protein) phosphatases II 186-329 5.9e-25 83.4 In-house 13-158 (174) alignment 
Range on Protein: 186-329
Range on HMM: 13-158/174.0
WIVPGKILAMSDPQRrnevkasrfakLRKHFRQNGVKTVVRLNRDDNMIKYGLVY----DARCFTANGFAHSDQYFEDGGIPTKAIVKRFTRILDHC---
........|.. | .             . ....|..|||.|..   . .|.       .   .. .|. . .  ..|.| |. .|. .| ......   
syitprliagqgpla...........fwemlkelgittvvmlleekelglykcinywpelredlerlgiqylylpwpDhgvpdlsillefvkfveealse

--EGAVAIHCRAGLGRTGTLIACYLIKQYKF-SAAEAVGWLRICR---PGSVSSLQH
  .| |..||.||.||||||.|.||...... |. .|. ..| .|   ||.| . ..
dpggpvlVHCsaGvgRtGtlvaaylmlrglleslvdaldlvrelRlqrpgmvqtpsQ
0037934 (Phosphotyrosine protein) phosphatases II 169-328 9.3e-25 83.0 In-house 10-229 (243) alignment 
Range on Protein: 169-328
Range on HMM: 10-229/243.0
DFDLNRYE--------------EDEKAFDSNWIVPgKILAMSDPQRRNEVKasRFAKLRKHFRQNGVKTVVRLNRDD--NMIKYGLV-------------
. . |||               .|    .  ...| .. |.. |   .     . |.  . . ..|....| |....  ...|.                
nlsknrysdilpydhsrvklegsdyinanliyvtp.rliatqgPlpetved..dlasfwrmlwelgitvivmltelvElgrekcaqywpgevtygdftvt

-------------------YDARCFTANGFAHSDQYFEDGGIPT-KAIVKRFTRI-LD-----------HCEGAVAIHCRAGLGRTGTLIACYLIKQY-K
                   .|.  .| ... .    . |.|.|.  ... .| ..  .           . .| |..||.||.||||||||.||.... .
llseehlddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRtGtliaaylmllllg

FSAAEAVGWLRICRPG-SVSSLQ
... ||| .|| .||| .| ...
vdleeavkllreqRpgkavqtps
0045098 (Phosphotyrosine protein) phosphatases II 207-333 1.2e-24 82.7 In-house 75-265 (278) alignment 
Range on Protein: 207-333
Range on HMM: 75-265/278.0
SRFAKLRKHFRQNGVKTVVRLNRDDNM----------------------------------I----KYGLVYDARCFTANGFAHSDQ-YFEDGGIPTKAI
| .|.  . ....|....|.|..   .                                  .     . | .    .. .|. | .   ..|.|.|.  |
stvadfwrmlwelgitvivmltelvelgrekcaqywpeggsltygdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpi

VKRFTRILD--------------------HCEGAVAIHCRAGLGRTGTLIACYLIKQY---KFSAAEAVGWLRICRPG-SV-SSLQHCFLE
.| | ..|.                      .| |..||.||.||||||.|.||....   .... ||| .|| .||| .| .  |  ||.
lksflellefirealkllaslllsslllldsggpvlVHCsaGvgRtGtlvaaylmlelleggvdlleavkelrsqRpglavqnleqyrfly
0048076 (Phosphotyrosine protein) phosphatases II 213-327 1.6e-23 78.4 In-house 22-129 (145) alignment 
Range on Protein: 213-327
Range on HMM: 22-129/145.0
RKHFRQNGVKTVVRLnrddnmikyglVYDARCFTANGFAHSDQYFEDGGIPTK-AIVKRFTRILDHC---EGAVAIHCRAGLGRTGTLIACYLIKQYKFS
.......|..||..|            .. . ....|. .    ..| |.|.  ... .| ......   .| |..||.||.||||||.|.||......|
lellkdlgittvlnl...........tselellerlgiqylylpwpDhgvpdllellleflefieealkeggpvlVHCsaGvgRtgtlvaaylmlllgvs

AAEAVGWLRICRPGSVSSL
. ||. ..| .|||.| . 
leealelvrsqrpgavpnp
0048179 (Phosphotyrosine protein) phosphatases II 213-327 2.2e-23 78.0 In-house 22-131 (144) alignment 
Range on Protein: 213-327
Range on HMM: 22-131/144.0
RKHFRQNGVKTVVRLNRDDnmikyglvyDARCFTANGFAHSDQYFEDGGIPTK-AIVKRFTRILDHC---EGAVAIHCRAGLGRTGTLIACYLIKQYKFS
 ......|..||..|. .          .  ... .|. .    ..| |.|.  ... .| ......   .| |..||.||.||||||.|.||.| ...|
lellkklgittvinlteey.........epefleregiqylhlpwpDhgvpdllellleflefieealeeggpvlVHCsaGvgRtgtlvaaylmkklgls

AAEAVGWLRICRPGSVSSL
. ||. ..| .|||.| . 
leealalvrsrrpgavpnp
subfamily_PTPDC1_pd Subfamily PTPDC1 176-328 1.5e-21 71.7 In-house 4-163 (182) alignment 
Range on Protein: 176-328
Range on HMM: 4-163/182.0
EEDEKAFD---SNWIVpGKILAMSDPQRRnEVKAsrfAKLRKHFRQNGVKTVVRLNRDDN-------MIKYGLVYDARCFTANGFAHSDQYFEDGGIPTK
.|.|.|..   |.|..  .|||.. |. . ....    || ..| ..|.|.|. |... .       . . |  ||   ....| ..    ..| | .. 
seeeqaikGlystWvt.edilalarpsqe.aide...yklldkfkesgikavinLqekgehasCGagleesGfsYdlealmeqgiyvynfgwkDygvasl

AIVKRFTRILDHC--EGAVAIHCRAGLGRTGTLIACYLIKQYKFSAAEAVGWLRICRPGSVSSLQ
  .    .... .  ||.||.|| ||||||| ||||||. . ...|..|.  .|  || |. . .
eriLdivkvvafalqegkvavhChaGlGrtGvliacylvyakrltaekaiklvrskrpksiqtre
0047943 (Phosphotyrosine protein) phosphatases II 208-330 1.5e-21 72.5 In-house 89-261 (273) alignment 
Range on Protein: 208-330
Range on HMM: 89-261/273.0
RFAKLRKHFRQNGVKTVVRLNRDDNM-----------------IKYGL--VY---------------------DARCFTANGFAHSDqyFEDGGIP-TKA
 ...  . . ...|...|.|......                 ..||   |.                     .  ..| . | . .  . | |.| . .
tvedfwrmvweqnvrviVmLtelvelgrekcaqYwpleggelsltygkftvtllseetkddytvrtleltnlgtgesrtvthfhytg..wpdhgvppsle

IVKRFTRILDH------CEGAVAIHCRAGLGRTGTLIACYLI-----KQYKFSAAEAVGWLRICRPGSVSSLQHC
.. .| .....       .| |..||.||.|||||.||..|.     | ..... ||| .|| .|||.| .... 
sllefielvrkalealpsngpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqy
0051429 (Phosphotyrosine protein) phosphatases II 184-328 9.3e-20 66.9 In-house 16-212 (272) alignment 
Range on Protein: 184-328
Range on HMM: 16-212/272.0
SNWIVPGKILAMSDPQRRNevkasrFAKLRKHfRQNGVKTVVRLNRDDNMIKYG-LVYDarcftaNGFAHSDQYFEDGGIPT------------------
 ....||...... | . .       | ...  ...|.||.| | ... . ...   |        |. .    ..| . ||                  
grvvkpgrlyrsggplplt......aadfwrl.kelgiktivdLrseeErgrlkcdryw......pgirylhlpilddsaptilygalrvtllseellld

-----------------------------------KAIVKRFTRILDhcEGAVAIHCRAGLGRTGTLIACYLIKqYKFS--------------AAEAVGW
                                   .|... .  .||  .|.| .||.|| .||||..|..|.  . .|              ..||| .
yilrellltlllsagearevmhlhytdwpdhgvpqeallellellld..ggpvlvHCsaGkdRTGtvvalllll.lgvsletivddYlltnlyleeavee

LRICRPGSVSSLQ
|| .|||.| . .
lraqrpgavqtee
0046845 (Phosphotyrosine protein) phosphatases II 215-330 1e-19 66.5 In-house 96-263 (284) alignment 
Range on Protein: 215-330
Range on HMM: 96-263/284.0
HFRQNGVKTVVRLNRDDNMIK-----------YGLVY----------------------------DARCFTANGFAHSDQYfeDGGIPT-KAIVKRFTRI
   ...|...| |.. ... .             |.|                            .   .| . | . .    | |.|.  ... .| |.
mvweqnvrvIVmltelvengrekcaqYwplegevltygdftvtllseevkddytvrtleltnlgytgesrtvthfhytswp..dhgvppspedlleflrl

LDHC------EGAVAIHCRAGLGRTGTLIACYLIKQY--------KFSAAEAVGWLRICRPGSVSSLQHC
....      .| ...||.||.|||||.||..|....        .... ||| .|| .|||.| .|.. 
vrellenlpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqy
0051299 (Phosphotyrosine protein) phosphatases II 217-330 4.3e-19 64.5 In-house 113-275 (288) alignment 
Range on Protein: 217-330
Range on HMM: 113-275/288.0
RQNGVKTVVRLNRDDNM---------------------------------IKYGLV--------YDARCFTANGFAHSDQYfeDGGIPT-KAIVKRFTRI
 ...|...|.|.. ...                                 ... |         .|  ..| . | . .    | |.|.    . .| |.
weqnvrvIvmltklvelgrekcaqYwplggsltygditvtllseevlddytvrtlevtnldlldgdgesrtvthfhytnwp..dhgvpdspellldflrl

LDHC----EGAVAIHCRAGLGRTGTLIACYLI-----KQYKFSAAEAVGWLRICRPGSVSSLQHC
....    .| |..||.||.|||||.||..|.     |...... ||| .|| .|||.| .... 
vrkalasgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtpeqy
0036941 (Phosphotyrosine protein) phosphatases II 217-329 8.9e-19 63.3 In-house 75-265 (297) alignment 
Range on Protein: 217-329
Range on HMM: 75-265/297.0
R------------------------QNGVKTVVRLNRDDNmikyglvydarcftaNGFAHSDQYF-----------------------------------
.                        ...|...| |....                .|.   .||.                                   
dlkrkfIatqgPlpntvedFWrmvweqnvtvIvmltelve...............lgrekcaqywpleegesltygdftvtllsvevvllddytlrtlev

-------------------EDGGIPT-KAIVKRFTRILDH------CEGAVAIHCRAGLGRTGTLIACYLI--------KQYKFSAAEAVGWLRICRPGS
                    | |.|.  |.. .| . ...       .| | .||.||.||.||.||..|.        |.....  ||| .|| .|||.
tdtgngesrtvthfhytgwpdhgvpespaslldfielvrkvlkllpsggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpga

VSSLQH
| .|..
vqtleq
subfamily_DSP23_pd Subfamily DSP23 259-328 1.2e-18 62.2 In-house 61-133 (148) alignment 
Range on Protein: 259-328
Range on HMM: 61-133/148.0
DGGIPTKAIVKRFTRILDHCE---GAVAIHCRAGLGRTGTLIACYLIKQYKFSAAEAVGWLRICRPGSVSSLQ
|   |.   |..| |...  |    ||..||  | |||||..||||.|. |..||||.  .|  ||||| ...
dyhppaleqvvefvrvveeaeekneavsvhcllgrgrtgtmlacylvkerklaaaeaiaevrrlrpgsvetve
subfamily_PRL_pd Subfamily PRL 211-336 3.3e-16 53.7 In-house 25-146 (151) alignment 
Range on Protein: 211-336
Range on HMM: 25-146/151.0
KLRKHFRQNGVKTVVRLNRddnmikygLVYDARCFTANGFAHSDQYFEDGGIPTKAIVKRFTRIL-----DHCEGAVAIHCRAGLGRTGTLIACYLIKQy
|  .......||||||             ||.. . ..|    |  |.||. |....|... ..|     .. . .||.|| |||||.  |.|  || . 
kfieelkkeevktvvrvce........ptydteklekegievldlafddGavPpeevveeWlellkekfkeepkstvavhcvaGlGraPvlvalaliea.

KFSAAEAVGWLRICRPGSVSSLQHCFLEHKQ
 ..  .|| ..|  | |.. | |  |||. .
Gmkyedavefirekrrgainskqlkflekyk
DSPc Dual specificity phosphatase, catalytic domain 276-328 1.4e-12 42.6 Pfam-A 70-122 (133) alignment 
Range on Protein: 276-328
Range on HMM: 70-122/133.0
DHCEGAVAIHCRAGLGRTGTLIACYLIKQYKFSAAEAVGWLRICRPGSVSSLQ
.  .. |..||.||. |..|||..||.|....|. ||.  ..  |.  . . .
eqkgkkvlVHCqaGisRSatliiaYlmktknlslneAyefvkerrskispnag
DSPc Dual specificity phosphatase, catalytic domain 276-328 1.4e-12 42.6 In-house 70-122 (133) alignment 
Range on Protein: 276-328
Range on HMM: 70-122/133.0
DHCEGAVAIHCRAGLGRTGTLIACYLIKQYKFSAAEAVGWLRICRPGSVSSLQ
.  .. |..||.||. |..|||..||.|....|. ||.  ..  |.  . . .
eqkgkkvlVHCqaGisRSatliiaYlmktknlslneAyefvkerrskispnag
subfamily_RNGTT_pd Subfamily RNGTT 240-324 5.3e-12 39.8 In-house 68-158 (189) alignment 
Range on Protein: 240-324
Range on HMM: 68-158/189.0
YDARCFTANGFAHSDQYFE-DGGIPTKAIVKRFTRIL-----DHCEGAVAIHCRAGLGRTGTLIACYLIKQYKFSAAEAVGWLRICRPGSV
||.. .. .|  .     .  |  |..  ||.| ...     .. |  ...||  |  ||| ||..||... ..|. .||   . .||  .
YdkeelekegikyvklqcagkgeaPeaeqvkefiklveeffkknpeevigvhCthGfnRtGFlivsyLvekedwsveaavalFakaRppGi
PTPc_motif_SM00404 276-325 7.4e-12 40.3 In-house 77-126 (140) alignment 
Range on Protein: 276-325
Range on HMM: 77-126/140.0
DHCEGAVAIHCRAGLGRTGTLIACYLIKQYKFSAAEAVGWLRICRPGSVS
   .|.| .||.||. |..|||..||......|.|||.  ..  ||    
ekkggkvlVHCqaGvSRSatliiaYlmryrqlslaeayefvkerRpiisp
subfamily_PTEN_pd Subfamily PTEN 174-313 2.2e-10 35.8 In-house 12-149 (184) alignment 
Range on Protein: 174-313
Range on HMM: 12-149/184.0
RYEEDEKAFDSNWIVPgKILAMSDPQRRNEVK-ASRFAKLRKHFRQNGVKTVVRLNRD--DnmikyglVYDARCFTANgFAHSdqYFEDGGIPTKA----
|..||.   |  .| . .|.||. |  . |     .  .. | . ..  . .  .|             ||.. |. .  |..   |.|   |.      
rfkedgldLDlsyite.niiamgyPaeklealyRnsledvvkflekkhkdhykiynlrser.......kydskkfdgr.vavy..pfdDhnppplellee

IVKRFTRILDHCE-GAVAIHCRAGLGRTGTLIACYLIKQYKFSAA-EAV
||.  .. |.. .   |..||.|| ||||.||..||.|. ... | ||.
ivediekwleedkknvvvvHCkaGkGRtGvlivayllkslllekaeeal
subfamily_PTPMT1_pd Subfamily PTPMT1 279-322 2.2e-10 35.2 In-house 107-150 (171) alignment 
Range on Protein: 279-322
Range on HMM: 107-150/171.0
EGAVAIHCRAGLGRTGTLIACYLIKQYKFSAAEAVGWLRICRPG
   | .||.|| ||..||.||||.|..|.|  ||.  |. .|. 
gkrvYvHCkaGrgRsatlvacylmkkeklspeeAlkalkkkRki
subfamily_DSP11_pd Subfamily DSP11 266-320 9e-09 29.5 In-house 103-157 (178) alignment 
Range on Protein: 266-320
Range on HMM: 103-157/178.0
AIVKRFTRILDHCEGAVAIHCRAGLGRTGTLIACYLIKQYKFSAAEAVGWLRICR
. ||.|.   .. .  ...||  |. ||| ||  |||..  ... .|.  .  .|
eavkefleknkdndkligvhCthGvnrtGyliCrylidvegyepedaieafeear
PTPc_DSPc_SM00012 276-331 1.2e-08 30.5 In-house 34-97 (105) alignment 
Range on Protein: 276-331
Range on HMM: 34-97/105.0
D---HcEGAVAIHCRAGLGRTGTLIACYLIKQYK------FSAAEAVGWLRICRPGSVSSLQHCF
    . .. | .||.|| |||||..| ... |        ..  . |  ||  |||.|....  .
nkses.skpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqyl
subfamily_DSP1_pd Subfamily DSP1 270-321 1.3e-08 29.1 In-house 86-137 (163) alignment 
Range on Protein: 270-321
Range on HMM: 86-137/163.0
RFTRILDHCEGAVAIHCRAGLGRTGTLIACYLIKQYKFSAAEAVGWLRICRP
 |     ...| | |||.||. |  ||.  ||.|. ..|  ||  . .  |.
efidevkkknGkvlihCqaGisRsstlclaylmktkrvsleeafdfvkqrRs
subfamily_DSP12_pd Subfamily DSP12 279-321 3.9e-08 27.8 In-house 82-124 (155) alignment 
Range on Protein: 279-321
Range on HMM: 82-124/155.0
EGAVAIHCRAGLGRTGTLIACYLIKQYKFSAAEAVGWLRICRP
|||| .|| ||. |  |... ||.|..|.|  .|.  ..  .|
egavlvHCqagvSRSvtiviAYlmkkeklslekAlklvkekkp
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 267-325 7e-08 26.5 In-house 204-267 (290) alignment 
Range on Protein: 267-325
Range on HMM: 204-267/290.0
IVKRFTRILDHCEGAVAIHCRAGLGRTGTLIACY-----LIKQYKFSAAEAVGWLRICRPGSVS
 . |  ||| .  | |..|| ||.|||||..|       |..  ..  .. |  || .| .|| 
allrtlrilrkasGpvvvhcsaGiGrtGtfvaievglqilldGkeldlldlvralrnsrlnsvq
subfamily_DSP19_pd Subfamily DSP19 277-321 9.6e-08 26.5 In-house 87-131 (152) alignment 
Range on Protein: 277-321
Range on HMM: 87-131/152.0
HCEGAVAIHCRAGLGRTGTLIACYLIKQYKFSAAEAVGWLRICRP
. .||| .||.||  |. ...  ||.|. . |  ||.  .|  ||
skdgavlvHCnAGvSRsasvviaylmkkeelsleealelvrearp
Y_phosphatase Protein-tyrosine phosphatase 261-328 1.3e-07 26.7 Pfam-A 147-224 (235) alignment 
Range on Protein: 261-328
Range on HMM: 147-224/235.0
GIP--TKAIVKRFTRILDHC---EGAVAIHCRAGLGRTGTLIACY-LIKQY----KFSAAEAVGWLRICRPGSVSSLQ
|.|  .|....  ...  .    .| | .|| || |||||..|   |..|     ...  ..|  || .|||.|.||.
gvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleqleaeeevdvlqivkelRkqRpgmvqsle
Y_phosphatase Protein-tyrosine phosphatase 261-328 1.3e-07 26.7 In-house 147-224 (235) alignment 
Range on Protein: 261-328
Range on HMM: 147-224/235.0
GIP--TKAIVKRFTRILDHC---EGAVAIHCRAGLGRTGTLIACY-LIKQY----KFSAAEAVGWLRICRPGSVSSLQ
|.|  .|....  ...  .    .| | .|| || |||||..|   |..|     ...  ..|  || .|||.|.||.
gvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleqleaeeevdvlqivkelRkqRpgmvqsle
subfamily_VSP_pd Subfamily VSP 271-311 4.6e-07 24.0 In-house 115-160 (212) alignment 
Range on Protein: 271-311
Range on HMM: 115-160/212.0
FTR----ILD-HCEGAVAIHCRAGLGRTGTLIACYLIKQYKFSAAE
||.     |.   .  .||||. | |||||.. ..|..   |. |.
ftkevkewlekdlknvlaihckGGkgrtGtivcalllaseifetak
subfamily_DSP10_pd Subfamily DSP10 277-322 7.1e-07 23.2 In-house 90-135 (159) alignment 
Range on Protein: 277-322
Range on HMM: 90-135/159.0
HCEGAVAIHCRAGLGRTGTLIACYLIKQYKFSAAEAVGWLRICRPG
...  | .||.||. |  |..  ||.|. . |  .|  . . .|| 
kkgsrvLvhCqaGisrsatvviaYlmkhlnlslndaykfvkekrpi
DSPc_SM00195 266-328 8.6e-07 23.9 In-house 182-249 (263) alignment 
Range on Protein: 266-328
Range on HMM: 182-249/263.0
AIVKRFTRILDHCEGAVAIHCRAGLGRTGTLIACYL-----IKQYKFSAAEAVGWLRICRPGSVSSLQ
.... ..   .. .| . .|| ||.|||||...  .      .. |..  | |  ||  |||.|..|.
ellravkkskstssgpivVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtle
PTPc_SM00194 266-328 8.6e-07 23.9 In-house 182-249 (263) alignment 
Range on Protein: 266-328
Range on HMM: 182-249/263.0
AIVKRFTRILDHCEGAVAIHCRAGLGRTGTLIACYL-----IKQYKFSAAEAVGWLRICRPGSVSSLQ
.... ..   .. .| . .|| ||.|||||...  .      .. |..  | |  ||  |||.|..|.
ellravkkskstssgpivVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtle
subfamily_DSP3_pd Subfamily DSP3 266-317 1.2e-06 22.3 In-house 84-135 (162) alignment 
Range on Protein: 266-317
Range on HMM: 84-135/162.0
AIVKRFTRILDHCEGAVAIHCRAGLGRTGTLIACYLIKQYKFSAAEAVGWLR
  .|   . |.. || | .||..|. |  ||.  ||. . |... ||.   |
taakfidealsqkegkvlvhcvvGvsRsatlvlayLmirrkmtlveairtvr
subfamily_DSP15_pd Subfamily DSP15 279-321 2e-06 22.0 In-house 78-120 (151) alignment 
Range on Protein: 279-321
Range on HMM: 78-120/151.0
EGAVAIHCRAGLGRTGTLIACYLIKQYKFSAAEAVGWLRICRP
|..| .|| ||. |  ||.. ||.   ...  .|.  .. .| 
eenvlvhClaGvsRsvtlvvaYlmtvtelnwrdalevikaaRs
subfamily_PTPN13_pd Subfamily PTPN13 272-302 4.1e-06 21.3 In-house 195-225 (273) alignment 
Range on Protein: 272-302
Range on HMM: 195-225/273.0
TRILDHCEGAVAIHCRAGLGRTGTLIACYLI
 | |.. .| ...|| ||.||.||||. . .
vrrlqtdagPivvhcsaGiGrsGtlitidvv
subfamily_CDKN3_pd Subfamily CDKN3 215-317 5.5e-06 20.1 In-house 65-171 (202) alignment 
Range on Protein: 215-317
Range on HMM: 65-171/202.0
HFRQNGVKTVVRLNRDDNMIKYGLVYDARCFTANGFAHSDQYFEDGGIPTKAIVKR----FTRILDHCEGaVAIHCRAGLGRTGTLIACYLIK-QYKFSA
...  ||. |  |    .. || .      ..  |..     . ||..|  |   .    ..  |.   .   .||  ||||.  .||| |.  .  .. 
elksqgvedvfvlctrgelskyrvrrlldlyqqaglivhhypiadglvpdiasclkileelrinlkayrk.tlvhcygglgrsslviaclllylddtiep

AEAVGWLR
 .|.  ||
kdaidklr
subfamily_DSP14_pd Subfamily DSP14 276-321 5.5e-06 20.4 In-house 80-125 (157) alignment 
Range on Protein: 276-321
Range on HMM: 80-125/157.0
DHCEGAVAIHCRAGLGRTGTLIACYLIKQYKFSAAEAVGWLRICRP
.. .|.. .|| ||  |  .|   ||.|  | | .||  ... .||
kkkggktlvhCvaGvSRSAslclaylmkyeklsLreayklvksaRp
subfamily_Dicty-DSP19-like_pd Subfamily Dicty-DSP19-like 279-322 6.4e-06 19.6 In-house 91-134 (154) alignment 
Range on Protein: 279-322
Range on HMM: 91-134/154.0
EGAVAIHCRAGLGRTGTLIACYLIKQYKFSAAEAVGWLRICRPG
.. | .|. .|. |. .|.  ||... | |  .|.  |. .|. 
nnkvlvhsdkGvsrsaallisylmdklkislslalellkdsryi
subfamily_LRR-DSP_pd Subfamily LRR-DSP 279-314 7.7e-06 19.2 In-house 197-232 (263) alignment 
Range on Protein: 279-314
Range on HMM: 197-232/263.0
EGAVAIHCRAGLGRTGTLIACYLIKQYKFSAAEAVG
.| | .|||||. |. ||. .||.|. ..   ||. 
kGGvlvhcraGvsrsstlvisylmkkqrlkfkeald
subfamily_PTPN12_pd Subfamily PTPN12 267-304 8.4e-06 19.9 In-house 195-232 (290) alignment 
Range on Protein: 267-304
Range on HMM: 195-232/290.0
IVKRFTRILDHCEGAVAIHCRAGLGRTGTLIACYLIKQ
... . .. .. .  ...|| || |||||.||  ....
lielvrelqesedaPlvvhCsaGvGrtGtiiaidyvre