Gene DSP14 in Nematostella vectensis

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family DSP
Subfamily DSP14
Protein sequence
ID Type Fasta BLAST phosphatome Note
NvecP008_AA protein Get Run
NvecP008_AA_16-161 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_DSP14_pd Subfamily DSP14 15-169 5.6e-69 225.1 In-house 3-156 (157) alignment 
Range on Protein: 15-169
Range on HMM: 3-156/157.0
PLTAMARITEWLFLSsCQVARDEKLLLEKGITLVINATIEAPEQDYKKVKHIRIKVNDNPGNKIGIFFDMVSDKIESVRRVGGKVLVHCIAGVSRSASLV
.|.|...||..|||| ...|....|| .|.|||.||.|.|.|....|........|.||| .|.  .||.|.||||.|.. |||.||||.|||||||||.
elaalsqitpsLfls.gvaalskellkkkkitliinvtvelpntklkdiervkvpveDnpeaklakhfdevadkieevkkkggktlvhCvaGvSRSAslc

IAYLMKYQRLNLRDAHKLVQDKRPLIRPNTGFWKELIDYEKKLFGKNSVQMVDTK
.||||||..|.||.|.|||...||.||||.||||.||||||||.||.||.|||..
laylmkyeklsLreayklvksaRpiirPNvGFwkqlidyEkklkgkssvkmvdsp
subfamily_DSP10_pd Subfamily DSP10 18-160 3.4e-42 138.0 In-house 13-156 (159) alignment 
Range on Protein: 18-160
Range on HMM: 13-156/159.0
AMARITEWLFLSSCQVARDEKLLLEKGITLVINATIEAPEQDYK-KVKHIRIKVNDNPGNKIGIFFDMVSDKIESVRRVGGKVLVHCIAGVSRSASLVIA
 ....  .||| | . |.|...| . .|| |.| | . | . .. ..|. ||.|.|.  ...   |.   . || .|. | .||||| ||.||||..|||
pasqvlpfLflGsekdaadldaldrlnitavlnvttsvPnefeeealkYkripvsDtskqnlkqyfeealefieearkkgsrvLvhCqaGisrsatvvia

YLMKYQRLNLRDAHKLVQDKRPLIRPNTGFWKELIDYEKKLFGK
||||...|.|.||.|.|..||| | || .|  .|...||.|  .
YlmkhlnlslndaykfvkekrpiisPnLnfmGqLlefekelnks
subfamily_DSP1_pd Subfamily DSP1 16-158 1.3e-41 136.4 In-house 14-157 (163) alignment 
Range on Protein: 16-158
Range on HMM: 14-157/163.0
LT-AMARITEWLFLSSCQVARDEKLLLEKGITLVINATIEAPEQDYKKVKHIRIKVNDNPGNKIGIFFDMVSDKIESVRRVGGKVLVHCIAGVSRSASLV
|   . .|...|.| |..|| . ..| ..||| ..|.. | ..   .  .. ..|..|.| . |   |. | . |..|.. .||||.|| ||.|||..|.
lydPvekildfLylGsetvasnleiLkslgitailnvskeldnvfedlfeYkklkleDspkadislvfeeviefidevkkknGkvlihCqaGisRsstlc

IAYLMKYQRLNLRDAHKLVQDKRPLIRPNTGFWKELIDYEKKLF
.||||| .|..| .|...|...|..|.||.|| ..|..||||| 
laylmktkrvsleeafdfvkqrRsiisPnagFvlqLlnyekkll
PTPc_motif_SM00404 19-156 4.6e-41 135.0 In-house 2-140 (140) alignment 
Range on Protein: 19-156
Range on HMM: 2-140/140.0
MARITEWLFLSSCQVARDEKLLLEKGITLVINATIEAPE-QDYKKVKHIRIKVNDNPGNKIGIFFDMVSDKIESVRRVGGKVLVHCIAGVSRSASLVIAY
. ||.. |.|.|.. | ...|| ..|||.|||.| | .  .  .......|...||  .|.  ..|.| | ||.... |||||||| |||||||.|.|||
psrilphlylgskskaqnpallkklgithvinvteevsltkensgfqilqiplddnekdklskyldkvldfienaekkggkvlVHCqaGvSRSatliiaY

LMKYQRLNLRDAHKLVQDKRPLIRPNTGFWKELIDYEKK
||.|. |.|..| ..|...|| |.||..|...||.||||
lmryrqlslaeayefvkerRpiispnlnfvrqLieyekk
subfamily_DSP19_pd Subfamily DSP19 18-157 9e-40 130.5 In-house 11-150 (152) alignment 
Range on Protein: 18-157
Range on HMM: 11-150/152.0
AMARITEWLFLSSCQVARDEKLLLEKGITLVINATIEAPEQDYKKVKHIRIKVNDNPGNKIGIFFDMVSDKIESVRRVGGKVLVHCIAGVSRSASLVIAY
 .. ....|.|.|..|| |.. | ||.|| ..| ... |.   |...   |.. |.| ...  ... . | ||..|.  | ||||| ||||||||.||||
evgeveprlylgsqdvaadkeilkekkitHilnvatgvpnvfpkdftylsieilDlpetdllsylkealdFieearskdgavlvHCnAGvSRsasvviay

LMKYQRLNLRDAHKLVQDKRPLIRPNTGFWKELIDYEKKL
||| ..|.|..| .||...|| |.||.||.| | .||..|
lmkkeelsleealelvrearpcikPneGFikqLkeyeael
DSPc Dual specificity phosphatase, catalytic domain 26-156 3.3e-39 128.8 Pfam-A 1-133 (133) alignment 
Range on Protein: 26-156
Range on HMM: 1-133/133.0
LFLSSCQVARdEKLLLEKGITLVINATIEAPE---QDYKKVKHIRIKVNDNPGNKIGIFFDMVSDKIESVRRVGGKVLVHCIAGVSRSASLVIAYLMKYQ
|.|.|.. |  ..|| ..|||||||.| | |.   .  .. ...||.|.|.  .||  ....... ||.... |.|||||| ||.||||.|.||||||..
lylgskstas.lalleklgitlvinvtkevpnnnaikkseieylripvedetetkiskeleeavefiekaeqkgkkvlVHCqaGisRSatliiaYlmktk

RLNLRDAHKLVQDKRPLIRPNTGFWKELIDYEKK
.|.|..| ..|...|. |.||.||...|..||.|
nlslneAyefvkerrskispnagflrqLleyerk
DSPc Dual specificity phosphatase, catalytic domain 26-156 3.3e-39 128.8 In-house 1-133 (133) alignment 
Range on Protein: 26-156
Range on HMM: 1-133/133.0
LFLSSCQVARdEKLLLEKGITLVINATIEAPE---QDYKKVKHIRIKVNDNPGNKIGIFFDMVSDKIESVRRVGGKVLVHCIAGVSRSASLVIAYLMKYQ
|.|.|.. |  ..|| ..|||||||.| | |.   .  .. ...||.|.|.  .||  ....... ||.... |.|||||| ||.||||.|.||||||..
lylgskstas.lalleklgitlvinvtkevpnnnaikkseieylripvedetetkiskeleeavefiekaeqkgkkvlVHCqaGisRSatliiaYlmktk

RLNLRDAHKLVQDKRPLIRPNTGFWKELIDYEKK
.|.|..| ..|...|. |.||.||...|..||.|
nlslneAyefvkerrskispnagflrqLleyerk
subfamily_DSP8_pd Subfamily DSP8 18-158 2.2e-37 122.1 In-house 14-155 (159) alignment 
Range on Protein: 18-158
Range on HMM: 14-155/159.0
AMARITEWLFLSSCQVARDEKLLLEKGITLVINATIEAPEQDY-KKVKHIRIKVNDNPGNKIGIFFDMVSDKIESVRRVGGKVLVHCIAGVSRSASLVIA
 . ||.. |.| | ... .|.|| ..||. |.||  . |...  |..| .|. |.|.  .|.  .||.  . |. ...  |.||||. || ||||...||
gptrilknlylGsqkdvlseellsklgisyvlnasnscpkleelkeskflrvPvkDkydekllpwfdksvefidkaksengrvlvhvlaGisrsatvaia

YLMKYQRLNLRDAHKLVQDKRPLIRPNTGFWKELIDYEKKLF
|.||. ...| .|.. |..|||.| ||  | . |..|||.| 
yimktlemsldeayrfvkekrptispnlnflgqLleyekelk
0044763 (Phosphotyrosine protein) phosphatases II 15-162 4.3e-37 122.8 In-house 19-175 (178) alignment 
Range on Protein: 15-162
Range on HMM: 19-175/178.0
PLTAMARITEWLFLSSCQVARDEKLLLEKGITLVINATIEAPEQ-------DYKK--VKHIRIKVNDNPGNKIGIFFDMVSDKIESVR-RVGGKVLVHCI
. . . .|.. |.|.|.  |.| .|| | |||...| | | .         ....  .....| . |..   .  .|. . . ||... . ||.||||| 
dyinaseilpglylgslppaddlellkelgithivnlteelelgflkcdpywpeeagiqylhipipDhgvpdllehflefvefieealdekggpvlVHCs

AGVSRSASLVIAYLMKYQRLNLRDAHKLVQDKRPlIRPNTGFWKELIDYEKKLFGKNS
|||.||..||.|||||...|.| .| .||. .|| | || |... |...|..|.....
aGvgRsgtlvaaylmkklglsleeaielvrerRp.ivpnpgqlrqLyefelrllkesd
subfamily_DSP12_pd Subfamily DSP12 19-157 5.2e-33 108.6 In-house 2-143 (155) alignment 
Range on Protein: 19-157
Range on HMM: 2-143/155.0
MARITEWLFLSSCQVARDEKLLLEKGITLVINATIEA---PEQDYKKVKHIRIKVNDNPGNKIGIFFDMVSDKIESVRRVGGKVLVHCIAGVSRSASLVI
. ||.. |.|.. . . .|.|| | .|| |.  . |.    ... .||..  |.. |.| . |  ..| . | ||. .  .|.||||| ||||||...||
vsrilpglylggleavqeeellkelkithvlsvikeelpehklkkgkvstkfiqilDepeediLshldeavdFieealeeegavlvHCqagvSRSvtivi

AYLMKYQRLNLRDAHKLVQDKRPLIRPNTGFWKELIDYEKKL
|||||...|.| .|.|||..|.| |.||.|| . |  .||  
AYlmkkeklslekAlklvkekkpeiepNegFleQLklfekmg
0048076 (Phosphotyrosine protein) phosphatases II 19-158 1e-32 108.1 In-house 4-143 (145) alignment 
Range on Protein: 19-158
Range on HMM: 4-143/145.0
MARITEWLFLSSCQVARDEKLLLEKGITLVINATIEAPEQDYKKVKHIRIKVNDNPGNKIGIFFDMVSDKIESVRRVGGKVLVHCIAGVSRSASLVIAYL
...|.. |.|.|. .|.| .|| . |||.|.| | | .    . ...... . |..   .  ... . . ||.... ||.||||| |||.|...||.|||
pseilpglylgslptaldlellkdlgittvlnltselellerlgiqylylpwpDhgvpdllellleflefieealkeggpvlVHCsaGvgRtgtlvaayl

MKYQRLNLRDAHKLVQDKRPLIRPNTGFWKELIDYEKKLF
|......| .| .||. .|| . || |... |...|..|.
mlllgvsleealelvrsqrpgavpnpgqlrflyefelell
subfamily_DSP3_pd Subfamily DSP3 15-158 1.6e-32 106.4 In-house 7-158 (162) alignment 
Range on Protein: 15-158
Range on HMM: 7-158/162.0
PLTAMARITEWLFLSSCQVARDEKLLLEKGITLVINATIE------APEQDYK--KVKHIRIKVNDNPGNKIGIFFDMVSDKIES-VRRVGGKVLVHCIA
. ...  ... |...  .||.|.. | . ||| |.||.        . .. ||  ..|.. ..|.|.|  ..  .|. ... |.. . .  ||||||| .
lskevdevypklyvgdeavakdkskLkklGithvlnaaegrfskvdtgaefykdleikylGlevdDvpefdlskyFetaakfidealsqkegkvlvhcvv

GVSRSASLVIAYLMKYQRLNLRDAHKLVQDKRPlIRPNTGFWKELIDYEKKLF
|||||| ||.|||| .....| .| . |..||  |.||.|| | |......| 
GvsRsatlvlayLmirrkmtlveairtvrkkRe.ilPneGFlkqLaeldeelk
subfamily_DSP6_pd Subfamily DSP6 15-157 1.9e-32 106.0 In-house 10-154 (158) alignment 
Range on Protein: 15-157
Range on HMM: 10-154/158.0
PLTAMARITEWLFLSSCQVARDEKLLLEKGITLVINATIEAPEQ--DYKKVKHIRIKVNDNPGNKIGIFFDMVSDKIESVRRVGGKVLVHCIAGVSRSAS
  .. ..|.. |.| | . | . ..| . .|  |.| | . |..  . ...|. .| ..|.  ...  ||    . |.  |.   ||||||.||.|||  
eaefpveilpllylGsakdasnlevlkklkikyvlnvtsnlpnkfeesgelkylqipiedhlsqnlakffPeaiefidearskkskvlvhClaGisrsvt

LVIAYLMKYQRLNLRDAHKLVQDKRPLIRPNTGFWKELIDYEKKL
...|||||.. | | ||..||..... | ||  | . |.|.|..|
vtlaylmkklalslndaydlvkkrksnisPnfnfmgqlldfersl
0048179 (Phosphotyrosine protein) phosphatases II 19-157 1.9e-32 107.3 In-house 4-144 (144) alignment 
Range on Protein: 19-157
Range on HMM: 4-144/144.0
MARITEWLFLSSCQVARDEKLLLEKGITLVINATIEAPEQDYKKV--KHIRIKVNDNPGNKIGIFFDMVSDKIESVRRVGGKVLVHCIAGVSRSASLVIA
...|.. |.|.|. .|.| .|| . |||.||| | | . .....   ..... . |..   .  ... . . ||.... ||.||||| |||.|...||.|
pseilpglylgslptaldlellkklgittvinlteeyepefleregiqylhlpwpDhgvpdllellleflefieealeeggpvlVHCsaGvgRtgtlvaa

YLMKYQRLNLRDAHKLVQDKRPLIRPNTGFWKELIDYEKKL
||||...|.| .| .||. .|| . || |... |..|||.|
ylmkklglsleealalvrsrrpgavpnpgqlrfLleyekll
subfamily_LRR-DSP_pd Subfamily LRR-DSP 21-161 3.1e-32 105.7 In-house 122-262 (263) alignment 
Range on Protein: 21-161
Range on HMM: 122-262/263.0
RITEWLFLSSCQVARDEKLLLEKGITLVINATIEAPEQDYKKVKHIRI-KVNDNPGNKIGIFFDMVSDKIESVRRVGGkVLVHCIAGVSRSASLVIAYLM
 | . ||| . . | .. .| ..|.| .. |  .      |  |.. | ...| .  .|  .|. .   ||. |. || ||||| ||||||..|||.|||
eiidklflGgldsannksilkdlgvthillavadfePlfPklfkylsiddiedvdeadisqhfeetnafieeGrkkGG.vlvhcraGvsrsstlvisylm

KYQRLNLRDAHKLVQDKRPLIRPNTGFWKELIDYEKKLFGKN
|.|||....|  ||. ||| |.||.|| . |  ||||||  |
kkqrlkfkealdlvikkrpriqPnpGfkdqlkkyekklfctn
subfamily_DSP15_pd Subfamily DSP15 19-157 5.1e-32 105.0 In-house 2-139 (151) alignment 
Range on Protein: 19-157
Range on HMM: 2-139/151.0
MARITEWLFLSSCQVARDEKLLLEKGITLVINATiEAPEQDYKKVKHIRIKVNDNPGNKIGIFFDMVSDKIESVRRVGGKVLVHCIAGVSRSASLVIAYL
. .. . |.|.  ....||.|| || || ...   . ...  |....  |...| |. |.  ||.   . | . |  ...|||||.||||||. ||.|||
iskvlpglylgnfrdskdeelLkeknithilsvh.dnakkllkdieYkciaasDtpsaklskffkesvefihkcRlkeenvlvhClaGvsRsvtlvvaYl

MKYQRLNLRDAHKLVQDKRPLIRPNTGFWKELIDYEKKL
|    || ||| . .. .| .  ||.|| . | .|||. 
mtvtelnwrdalevikaaRsvanPnfGfkrqlkeyektk
0041856 (Phosphotyrosine protein) phosphatases II 19-161 1.9e-31 104.4 In-house 19-176 (182) alignment 
Range on Protein: 19-161
Range on HMM: 19-176/182.0
MARITEWLFLSSCQV--------------ARDEKLLLEKGITLVINATIEAPEQDYKKV---KHIRIKVNDNPGNKigifFDMVSDKIESVRRVGGKVLV
. .|.. |.|.|.                |.. ..| | |||...|.| |    .. .    ..... . |..       .|.. | || |.. ||.|||
ldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlteelywpellerlgiqylylpwpDhgvpd....ldelldfieevleeggpvlV

HCIAGVSRSASLVIAYLMKYQRLNLRDAHKLVQDKRP--LIRPNTGFWKELIDYEKKLFGKN
|| |||.|...||.|||||.....|..| |||. .||   |.|| .|.  |. .|..|..|.
HCsaGvgRtgtlvaaylmkklgvsleeavklvrsrRpgmvitpnqyfflqlallellllkkt
subfamily_Slingshot_pd Subfamily Slingshot 18-158 3.6e-31 101.8 In-house 18-158 (169) alignment 
Range on Protein: 18-158
Range on HMM: 18-158/169.0
AMARITEWLFLSSCQVARDEKLLLEKGITLVINATIEAPEQDYKKVKHIRIKVNDNPGNKIGIFFDMVSDKIESVRRVGGKVLVHCIAGVSRSASLVIAY
. ..| ....| |   | . . | |.|.. ..| | |  .   .|.....|.| |.. ...  ...   . || ... | ||||||  ||||||| ||||
saskifdhvylGsewnasnleelkengveyilnvtkeidnffpekfeylnirvydeeetdllkywnetykfiekakkkgskvlvhckmGvsrsastviay

LMKYQRLNLRDAHKLVQDKRPLIRPNTGFWKELIDYEKKLF
 ||  .|.| .|.. |...| .|.||.||.| |  ||  | 
amkeyglsleealeyvkerrsvikPnkgflkqleeyeGile
subfamily_Choan-DSP_MKP-1_pd Subfamily Choan-DSP_MKP-1 24-155 3.1e-30 98.6 In-house 13-145 (148) alignment 
Range on Protein: 24-155
Range on HMM: 13-145/148.0
EWLFLSSCQVARDEKLLLEKGITLVINATIEAPEQ-DYKKVKHIRIKVNDNPGNKIGIFFDMVSDKIESVRRVGGKVLVHCIAGVSRSASLVIAYLMKYQ
 .||| | . | | . | . |.| ..||| | .   | . .... ....|.| . .  .|. . . .. ..  |..||||.  |||||. |....|....
afLFlGskksaadlealkalgvtrivnatkerdnaldqrgieYlhvaldDkpkedlsaiFediiafvrkakdeGrrvLvhlqmGvsrssalallwlidfk

RLNLRDAHKLVQDKRPLIRPNTGFWKELIDYEK
|  |..|  ||..||. ..|| || | | ..|.
rvslkealalvkskrryvdpnlgfLkqLaeleq
subfamily_MKPLT_pd Subfamily MKPLT 24-160 2.2e-28 92.8 In-house 27-163 (164) alignment 
Range on Protein: 24-160
Range on HMM: 27-163/164.0
EWLFLSSCQVARDEKLLLEKGITLVINATIEAPEQDYKKVKHIRIKVNDNPGNKIGIFFDMVSDKIESVRRVGGKVLVHCIAGVSRSASLVIAYLMKYQR
. |.|   . |..||.| .  || ..| . |  ..  | |.. ..||.|.. .... |.. ... . .    ||.|||||  |.|||.|  .|.|.|...
dtlylGnakhatnekvlkdlkithivnvsqekkdafpksveYlqvkvedesdeqlssfleraakfladaidsGGrvlvhcvqGksrsssvtvafLikskg

LNLRDAHKLVQDKRPLIRPNTGFWKELIDYEKKLFGK
  |..|.. ....| ...|| || |.|  .|. ..||
wtlkeayeylkerrsivapnrGflkqlakfeelilGk
subfamily_MKPLV_pd Subfamily MKPLV 24-160 2.2e-28 92.8 In-house 27-163 (164) alignment 
Range on Protein: 24-160
Range on HMM: 27-163/164.0
EWLFLSSCQVARDEKLLLEKGITLVINATIEAPEQDYKKVKHIRIKVNDNPGNKIGIFFDMVSDKIESVRRVGGKVLVHCIAGVSRSASLVIAYLMKYQR
. |.|   . |..||.| .  || ..| . |  ..  | |.. ..||.|.. .... |.. ... . .    ||.|||||  |.|||.|  .|.|.|...
dtlylGnakhatnekvlkdlkithivnvsqekkdafpksveYlqvkvedesdeqlssfleraakfladaidsGGrvlvhcvqGksrsssvtvafLikskg

LNLRDAHKLVQDKRPLIRPNTGFWKELIDYEKKLFGK
  |..|.. ....| ...|| || |.|  .|. ..||
wtlkeayeylkerrsivapnrGflkqlakfeelilGk
0049772 (Phosphotyrosine protein) phosphatases II 23-159 2.5e-28 95.1 In-house 155-275 (314) alignment 
Range on Protein: 23-159
Range on HMM: 155-275/314.0
TewlflsSCQVARDEKLLLekgitlvinaTIEAPEQDYKK--VKHIRIKVNDnPGNKIGIFFDMVSDKIESVrRVGGKVLVHCIAGVSRSAS-LVIAYLM
.      .  .|.| .||           ..  . .....  .|..|| | | ..  .  .|| . . ||.. . ||.||||| ||..|... .|.||||
g......neptaadlellk..........eelydpelferlgikylripvpD.gsaplledfdeflefieea.dkggpvlvHCkaGkgRtgtfvvaaylm

KYQRLNLRDAHKLVQDKRPlIRPNTGFWKELIDYEKKLFG
|.....|..| . |. ||| |.|| ||.. |..||..|  
kllgvsleealedvrlkRp.inpnpgfieqleqyefilea
0043147 (Phosphotyrosine protein) phosphatases II 21-158 1.1e-27 92.2 In-house 21-161 (172) alignment 
Range on Protein: 21-158
Range on HMM: 21-161/172.0
RITEWLFLSSCQVARDEKLLLEKGITLVINATiE----APEQDYKKVKHIRIKVNDNPGNkIGIFFDMVSDKIES--VRRVGGKVLVHCIAGVSRSASLV
|.  .... .. .| . ..| |.|||...|.| |    ..      ...... . |..   .  ... . . |..  ... ||.||||| |||.|.. ||
rfiatqgplrntladfwrmlkelgithivnlt.ellydpellerlgiqylylpwpDhgvp.llellleflefidellalspggpvlVHCsaGvgRtgtlv

IAYLMKyQRLNLRDAHKLVQDKRPLIRPNTGFWKELIDYEKKLF
.||||. ..|.| .| .||..||| . .| .... | ..||.|.
aaylml.lglsleeavalvrekRpgavqnpsqyrflyyfeklll
0049260 (Phosphotyrosine protein) phosphatases II 21-157 3.9e-27 90.2 In-house 10-149 (152) alignment 
Range on Protein: 21-157
Range on HMM: 10-149/152.0
RITEWLFLSSCQVARDEKLLLEKGITLVINATIEAPEQDYKKV---KHIRIKVNDNPGNKIGIFFDMVSDKIES-VRRVGGKVLVHCIAGVSRSASLVIA
... .... .  .| . ..| | ||| ... | . .   .|     ..... . |..  .. ...... . ||   .. ||.||||| |||.|.. ||.|
efiatqgpgpntladfwrmlkelgittivmltellelgklkceqyiqylhlpwpDhgvpdlsqlllflllfieklaldkggpvlVHCsaGvgRtgtlvaa

YLMKyQRLNLRDAHKLVQDKRPLIRPNTGFWKELIDYEKKL
|||. ....| .| .||. ||| . || |... | ..||.|
ylml.lgvsleeavalvrekRpgavpnpgqlrflyefekll
0045098 (Phosphotyrosine protein) phosphatases II 18-159 5.9e-27 90.2 In-house 21-273 (278) alignment 
Range on Protein: 18-159
Range on HMM: 21-273/278.0
AMARITEWLFLSSCQ-----------------------------------------VARDEKLLLEKGITLVINAT------------------------
 . .||..|.|..                                           || . ..| | ||| ....|                        
ipseitpalylgnldknRykdilpydhsrVkdYINAsyidgypkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrekcaqywpeggsltygd

-----------------------I----EAPEQdyKKVKHI---RIKVNDNPGNKIGIFFDMVSDKIESVRR--------------VGGKVLVHCIAGVS
                       .    |  |.   .|.|.    .  .. | . |  .|. . . |.....               ||.||||| |||.
ftvtllseevlddytlrtllvtnltveredles..rgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsggpvlVHCsaGvg

RSASLVIAYLMKYQ---RLNLRDAHKLVQDKRPL-IRPNTGFWKELIDYEKKLFG
|.. ||.||||...   ...| .| | .. .||  . .| .... |.... .|. 
RtGtlvaaylmlelleggvdlleavkelrsqRpglavqnleqyrflyefllelll
PTEN_1 33-158 1.6e-26 88.3 In-house 56-192 (196) alignment 
Range on Protein: 33-158
Range on HMM: 56-192/196.0
VARDEKLLLEKGITLVINATIEAPE--QDY-------KKVKHIRIKVNDNPGNKIGIFFDMVSDKIESVRR--VGGKVLVHCIAGVSRSASLVIAYLMKY
||.| . | |.|||||.| . | ..  ..|       ..|..... ..| .   .  .||.. . ||....   |..||||| ||..||. .|.||||..
vaadldnlkedgitlvvnlseeeelsgrsydleeffksgveylhfpieDhgapslselfdicksfiewllsdpngnvVlVHCkaGlgRsGtvvaayLmyk

QRLNLRDAHKLVQDKRPLIRPNTGFWKELIDYEKKLF
..|. ..| .||..||| ..||......|. |...|.
gkltadeAlelvrekRppgapnspsqerlleyfaell
0051082 (Phosphotyrosine protein) phosphatases II 14-154 2.6e-26 87.4 In-house 3-150 (151) alignment 
Range on Protein: 14-154
Range on HMM: 3-150/151.0
SPLTAMARITEWLFLSSCQVARDEKLLLEKGITLVINATIEA---PEQDYKK---VKHIRIKVNDNPGNKIGIFFDMVSDKIESVRRV-GGKVLVHCIAG
|... . ..|. |..|..  |.. .|| | ||. ..| . |     . .| .   .....| . |.|  .. ..|| | . .| ...  .|.||||| ||
sdyinfsyvtgglyrsggpladflellkelgiktivnlrseeergycpeylpelgievlhipildwpdpglplsfdavleflellldkkngpvlvHCsaG

VSRSASLVIAYLMKyQRLNLRDAHKLVQDKRP-LIRPNTGFWKELIDYE
..|.. ||..|||. ....| .| . .. ||| ...||..|...|....
kgRTGtlvalylml.lgvsleealeeyrlkrpgvvqpnqqflfqlfall
subfamily_STYX_pd Subfamily STYX 18-165 3.2e-26 85.4 In-house 11-165 (166) alignment 
Range on Protein: 18-165
Range on HMM: 11-165/166.0
AMARITEWLFLSSCQVARDEKL--LLEKGITLVI--NATIEA----PEQdYKKVKHIRIKVNDNPGNKIGIFFDMVSDKIESVRRVGGKVLVHCIAGVSR
 |  |   |||     |   ||  | ..||| ..    .|||    |.   .. ... . | ||. ..|  .. .| . |..  . |||||||  ||.||
emqeilpglflgpysaamksklevlkkhgithivcirqnieanlikpnf.pdrfrylvldvadntveniirylptvkefiddslqkggkvlvhgnagisr

SASLVIAYLMKYQRLNLRDAHKLVQDKRPLIRPNTGFWKELIDYEKKLFGKNSVQM
||.|||||.|.   |. |.|.. ||..|  | || || ..| .||   . | ....
saalviayimetyglkyreafayvqerrfcinpnegfvsqlkeyeaiylakltikl
0040439 (Phosphotyrosine protein) phosphatases II 34-159 2.4e-25 85.0 In-house 68-247 (249) alignment 
Range on Protein: 34-159
Range on HMM: 68-247/249.0
ARDEKLLLEKGITLVINATIEAPE-------------------------------------------QDYKKVKHIRIKVNDNPGNKIGIFFDMVSDKIE
. . ..| | ||| ....| . .                                            .| ....   | . | |  ..  .|. . | ||
edfwrmlwelgitvivmLtslvelgrekcaqywplggsleygdftvtllsvevkddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldfie

SVRR------VGGKVLVHCIAGVSRSASLVIAYLM-----KYQRLNLRDAHKLVQDKRPLIRPNTGFWKELIDYEKKLFG
 ||        ||.||||| |||.|.. ...||||     |.....| .| ||....|| . .| .... |......|. 
avrkaleelpkggpvlVHCsaGvgRtGtfiaaylmleqlekelgvdleeavkllrsqRpgavqnpeqyrflyeallelll
0046846 (Phosphotyrosine protein) phosphatases II 16-159 3.2e-25 84.3 In-house 9-174 (176) alignment 
Range on Protein: 16-159
Range on HMM: 9-174/176.0
LTAMARITEWLFLSSCQ----------VARDEKLLLEKGITLVINATIEA-----------PEQDYKKVKHIRIKVNDNPGNKIgIFFDMVSDKIESVRR
   . .|.. |.|.|.           .| . ..|.| |||.|.| | |            ||    ....... . |.    .   .. . . |.....
dldldyinanlilgsrpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgiqylhlpwpDhgvpdl.elllellefirealk

VGGKVLVHCIAGVSRSASLVIAYLMKY-QRLNLRDAHKLVQDKRP-LIRPNTGFWKELIDYEKKLFG
 ||.||||| ||..|.. ||.|||... . |.. .| .||...||  . .. .... | ..|..|..
eggpvlVHCsaGigRtgtlvaayllelekglsveealalvreqRplgavqtpeQyrflyefellllk
0036282 (Phosphotyrosine protein) phosphatases II 17-157 1.3e-24 82.2 In-house 10-169 (174) alignment 
Range on Protein: 17-157
Range on HMM: 10-169/174.0
TAMARITEWLFLSSCQVArDEKLLLEKGITLVINATIEAPEQ---------------DYKKVKHIRIKVNDNPGNKIGIfFDMVSDKIESVRRV--GGKV
  . .||. |.....  | . ..| | ||| |.. . | . .                   ...... . |.    . | .. . . .|...    ||.|
ldlsyitprliagqgpla.fwemlkelgittvvmlleekelglykcinywpelredlerlgiqylylpwpDhgvpdlsi.llefvkfveealsedpggpv

LVHCIAGVSRSASLVIAYLMKYQRL-NLRDAHKLVQDKR---PLIRPNTGFWKELIDYEKKL
|||| |||.|.. ||.||||... | .|.|| .||. .|   | . .. .... | ..||.|
lVHCsaGvgRtGtlvaaylmlrglleslvdaldlvrelRlqrpgmvqtpsQyrflyyfekll
0045450 (Phosphotyrosine protein) phosphatases II 38-158 2.3e-24 82.1 In-house 125-304 (307) alignment 
Range on Protein: 38-158
Range on HMM: 125-304/307.0
KLLLEKGITLVINATIEAPE----------------------------QDYKKVKHIRIKVNDN-----------------PGNKIGIFFDMVSDKIESV
..| |.|.|.... | . .                             . ...... ...| |.                 |. ..  .|... | || |
rmlweqgvtvivmltelvelgrekcaqywPdegeeltygnftvtllseehldgytvrtlevtdldgtgesrtvthfhytgwpdhgvppsfeelldfieev

RR------VGGKVLVHCIAGVSRSASLVIAYLMKYQR--------LNLRDAHKLVQDKRPLIRPNTGFWKELIDYEKKLF
|.       ||.||||| |||.|......||||..|.        ..|..| ||....|| . .| .... |......|.
rkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyeallell
0037934 (Phosphotyrosine protein) phosphatases II 20-158 4.4e-24 80.8 In-house 40-242 (243) alignment 
Range on Protein: 20-158
Range on HMM: 40-242/243.0
ARITEWLFLSSC--------QVARDEKLLLEKGITLVINATIEA---------------------------------------------PEQDYKKVKHI
 ..|. |.....         .| . ..| | ||| ... | .                                              ... .  ... 
iyvtprliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywpgevtygdftvtllseehlddytvrtlllenldlddltrlvihyh

RIKVND----NPGNKIGIFFDMVSDKIES-----VRRVGGKVLVHCIAGVSRSASLVIAYLMKYQ-RLNLRDAHKLVQDKRPL-IRPNTGFWKELIDYEK
.. . |    .  . .  |.|.| . ||.     ..  ||.||||| |||.|.. |..||||... ...| .| ||....||  . .. .... |.....
ylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRtGtliaaylmllllgvdleeavkllreqRpgkavqtpsqyrflyeall

KLF
.|.
ell
subfamily_Dicty-DSP19-like_pd Subfamily Dicty-DSP19-like 23-157 5.7e-24 78.2 In-house 7-152 (154) alignment 
Range on Protein: 23-157
Range on HMM: 7-152/154.0
TEWLFLSSCQVARDEKLLLEKGITLVINATIEAPEQDYKK---------VKHIRIKVNDNPGNKI----GIFFDMVSDKIESVRRvgGKVLVHCIAGVSR
.  |..|| . | .  .| .| |. ..|  |  ..   ..         ........ |..  .|       |... |.| .|..  .|||||. .||||
aiflyissfdaalnkldlqlkniksilnvgiGinnlftdensdindgfiieylnlelfddvnfdiiekldkafefiddaiggven..nkvlvhsdkGvsr

SASLVIAYLMKYQRLNLRDAHKLVQDKRPLIRPNTGFWKELIDYEKKL
||.|.|.|||. ....|  | .|..| |. |.||.|| | |  .||.|
saallisylmdklkislslalellkdsryiikPnqGflkqleifekel
0040438 (Phosphotyrosine protein) phosphatases II 39-161 6e-23 77.0 In-house 105-279 (317) alignment 
Range on Protein: 39-161
Range on HMM: 105-279/317.0
LLLEKGITLVINATIEAPEQ---------------------------DYKKVKHIRIKVNDN----------------PGNKIGIFFDMVSDKIESVRRV
.. | |.|.... | . . .                            .. ... ...| |.                |  ..   .| . | .| ||..
mvweqgvtvivmLteleelgrekcaqYwplgetltygdftvtllseeelagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfleavrea

----GGKVLVHCIAGVSRSASLVIAYLM-----KYQRLNLRDAHKLVQDKRPLIRPNTGFWKELIDYEKKLFGKN
    ||.||||| |||.|......||||     |...... .| | .. .|| . .. .... |.|.. ... ..
ledpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalleylkrk
0042113 (Phosphotyrosine protein) phosphatases II 20-158 2.1e-22 75.2 In-house 48-243 (245) alignment 
Range on Protein: 20-158
Range on HMM: 48-243/245.0
ARITEWLFLSSCQVARDEK----LLLEKGITLVINATIEAPE-------------------------------------------QDYKKVKHIRIKVN-
 |||. ......  . . .    .| | ||| ... | | .                                            .|... ..|..    
yritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywplgesltygdftvtllseehlddytvrtlevtnlgddesrevihyhylp

--DNPGNKIGIFFDMVSDKIESVRR--VGGKVLVHCIAGVSRSASLVIAYLM-----KYQRLNLRDAHKLVQDKRPLIRPNTGFWKELIDYEKKLF
  |..   .   .. . . ......   .|.||||| |||.|.. ...||||     |.....| .| | ....|| .... .... |......|.
wpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylmleqlekelgvsleeavkelrsqRpgavqtpsqyrflyeallell
subfamily_Sponge-DSP-Subfam1_pd Subfamily Sponge-DSP-Subfam1 27-157 2.1e-21 69.5 In-house 7-141 (145) alignment 
Range on Protein: 27-157
Range on HMM: 7-141/145.0
FLSSCQVARDEKLLLEKGITLVINAT----IEAPEQDYKKVKHIRIKVNDNPGNKIGIFFDMVSDKIESVRRVGGKVLVHCIAGVSRSASLVIAYLMKYQ
.  |   |.|  .| | ||. ..| .    . . |   .... . |  .|     .   || |.| |.  .  |  |.|||.|||||| .. .|.|||| 
yvgsalhandvptlqelgisrivnmaagslvasqelksesieillitaedlesydlsqhfdevtdfidkgkeegagvfvhcmagvsrsvtvsvaflmkyc

RLNLRDAHKLVQDKRPLIRPNTGFWKELIDYEKKL
 . | .| . |. .| |  ||  | |.|.. ||.|
nmtlseaarqvrsnrllaypnvtflknllnlekql
0038934 (Phosphotyrosine protein) phosphatases II 41-157 3.7e-21 71.1 In-house 53-176 (194) alignment 
Range on Protein: 41-157
Range on HMM: 53-176/194.0
LEKGITLVINATIEAPEQDYKKVKHIRIKVNDNPG---------NKIGIFFDMVSDKIEsvRRVGGKVLVHCIAGVSRSASLVIAYLMKYQRLNLRDAHK
| ....|||. | . .  |.....   |.. . |          . .  |.|.| ....  .  ||.|.||| ||..|.. ||.|||..........| .
lnvklglvidltnteryYdpeefekagieylklpfpddgtvPsleillrfldlvdefln..edpggvvaVHCkaGlgRtGtlvaaYLiyrlgmsaeeAia

LVQDKRPLIRPNTGFWKELIDYEKKL
|...||| . || .....|  . | |
lfrekRpgaipnqdyleallkrykel
0036941 (Phosphotyrosine protein) phosphatases II 22-169 9.1e-21 69.8 In-house 22-288 (297) alignment 
Range on Protein: 22-169
Range on HMM: 22-288/297.0
ITEWLFLSSCQVARDEK----------------------------------------------------------LLLEKGITLVINATIEAPE------
....|.| |. ||. ..                                                          ...| ..| ... | . .       
llpllllgslsvallpenleknRykdilpydhtRVklddegsdYinAsyvdgydlkrkfIatqgPlpntvedFWrmvweqnvtvIvmltelvelgrekca

-------QDYKKVKHIRI--------------------K--------------VNDNPGNKIGIFFDMVSDKIESVRR------VGGKVLVHCIAGVSRS
       ...........                    .              . . | ...   .. . | || ||.       ||.||||| |||.||
qywpleegesltygdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfielvrkvlkllpsggpvlVHCsaGvgRs

ASLVIAYLM--------KYQRLNLRDAHKLVQDKRPLIRPNTGFWKELIDYEKKLFGKNSVQMVDTK
.....|.||        |...... .| | . ..|| . .. .... |.... .|. |. . . . |
gtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallellkkkltkepllk
subfamily_STYXL1_pd Subfamily STYXL1 24-160 1.7e-20 66.8 In-house 17-156 (157) alignment 
Range on Protein: 24-160
Range on HMM: 17-156/157.0
EWLFLSSCQVARDEKLLLEKGITLVINATIEAPE---QDYKKVKHIRIKVNDNPGNKIGIFFDMVSDKIESVRRVGGKVLVHCIAGVSRSASLVIAYLMK
. |.|   . | ....  .  .  ..| . .| .    . . .| ..|.|.|..  ..  ... . . ||. .. |  |||    |.||||...||||| 
gklylGnykqaqnpaikkdlkvkahvnvsmdadkliagvadvakllhiavedeneadllerlkeavqfiekhkkegevvlvfsnkGisrsaaviiaylmy

YQRLNLRDAHKLVQDKRPLIRPNTGFWKELIDYEKKLFGK
.....|..|.| ... .. ..|| .| . | ..||.|.|.
skkitlkkaykylkkCkenvkPnrafveqlseWekqllge
0039614 (Phosphotyrosine protein) phosphatases II 39-160 6.7e-20 67.2 In-house 120-291 (297) alignment 
Range on Protein: 39-160
Range on HMM: 120-291/297.0
LLLEKGITLVINATIEAPEQ---------------------------DYKKVKHIRIK---------------VNDNPGNKIGIFFDMVSDKIESVRR--
.. | |.| ... | . . .                           |. .| .....                 |.    .   .. . ........  
mvweqgvtvivmLtklvelgrkcaqywpeeggtygdftvtllkvehldgytvrtlevtnngesrtvthfqytgwpdhgvppslellleflelvrealael

-VGGKVLVHCIAGVSRSASLVIAYLM-----KYQRLNLRDAHKLVQDKRPLIRPNTGFWKELIDYEKKLFGK
  ||.||||| |||.|......||||     |...... .| | .. .|| .... .... |.|....|. .
pkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydallellkr
0051429 (Phosphotyrosine protein) phosphatases II 26-158 7.4e-19 63.9 In-house 24-225 (272) alignment 
Range on Protein: 26-158
Range on HMM: 24-225/272.0
LFLSSCQ---VARDEKLLLEKGITLVINATIEAPEQDYK------KVKHIRIKVNDNPGNKIGIFF----------------------------------
|..|..     |.| . | | ||. ... . |   . .|       ...... ..|.    | ...                                  
lyrsggplpltaadfwrlkelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseellldyilrellltlllsagearevm

--------------DMVSDKIESVRRvGGKVLVHCIAGVSRSASLVIAYLMKyQRLN--------------LRDAHKLVQDKRPLIRPNTGFWKELIDYE
              . . . .| ... ||.||||| ||..|.. .| ..|.  ....              |..| . ....|| .... .... | ...
hlhytdwpdhgvpqeallellellld.ggpvlvHCsaGkdRTGtvvalllll.lgvsletivddYlltnlyleeaveelraqrpgavqteeqylflyeal

KKLF
..|.
lell
0043336 (Phosphotyrosine protein) phosphatases II 40-156 8.3e-19 63.5 In-house 108-275 (278) alignment 
Range on Protein: 40-156
Range on HMM: 108-275/278.0
LLEKGITLVINAT-----------------------------------------------IEAPEQDYKKVKHIRIKVNDNPGnKIGIFFDMVSDKIESV
. | |.| ... |                                                . ...    . .. .  .. |   . ...|.. . .| .
vwelgvttivmLtelvelgrvkcaqYwpggsltygdftvtllkeehlddytvrtlevtnlgdgesrtvthyhylgwpdhgvpe.slsllldflkavreal

RRVGGKVLVHCIAGVSRSASLVIAYLM-----KYQRLNLRDAHKLVQDKRPLIRPNTGFWKELIDYEKK
.  .|.||||| |||.|.. ....||.     |.....| .| | .. .|| . ..  ... |..... 
edsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflyealle
subfamily_MSG5_pd Subfamily MSG5 46-157 3.2e-18 59.4 In-house 49-160 (165) alignment 
Range on Protein: 46-157
Range on HMM: 49-160/165.0
TLVINATIEAPEQDYK--KVKHIRIKVndNPGNKIGIFFDMVSDKIESVRRVGGKVLVHCIAGVSRSASLVIAYLMKYQRLNLRDAHKLVQDKRPLIRPN
 |||| . |... ...   ||.  |.   .   ||   .  ..  | . .  . |.||||  |.||||||..||.|||  | ||||..... .   | |.
dlvinvakeindlellvpavkyyhiew..ehdskivkdlsrltriihaatskrkkilvhcqcglsrsaslivayimkyynlslrdaydklksvaddisps

TGFWKELIDYEKKL
 |.  .|...|  |
iglifqlmeweval
subfamily_PTPMT1_pd Subfamily PTPMT1 63-157 3e-17 57.6 In-house 74-168 (171) alignment 
Range on Protein: 63-157
Range on HMM: 74-168/171.0
VKHIRIKVNDNP-GNKIGIFFDMVsDKIESVRRVGGKVLVHCIAGVSRSASLVIAYLMKYQRLNLRDAHKLVQDKRPLIRPNTGFWKELIDYEKKL
|....... |     ..   .. | . ||.|.  | .| ||| || .|||.||..|||| ..|.. .|.| ...||. || ..  || |  ||.||
veqlqlatvDfteapdleklekgv.efiekvaskgkrvYvHCkaGrgRsatlvacylmkkeklspeeAlkalkkkRkiirlakkqwkalqeyeekl
0047943 (Phosphotyrosine protein) phosphatases II 74-150 9e-14 47.0 In-house 177-264 (273) alignment 
Range on Protein: 74-150
Range on HMM: 177-264/273.0
PGNKIGIFFDMVSDKIESVRR------VGGKVLVHCIAGVSRSASLVIAYLM-----KYQRLNLRDAHKLVQDKRPLIRPNTGFWKEL
| ...   .... . || ||.       .|.|.||| |||.|........|.     |...... .| ||....|| . ..  ... |
pdhgvppslesllefielvrkalealpsngpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrfl
0051299 (Phosphotyrosine protein) phosphatases II 61-143 2.4e-13 45.7 In-house 182-271 (288) alignment 
Range on Protein: 61-143
Range on HMM: 182-271/288.0
KKVKHIRIK--VNDNPGNKIGIFFDMVSDKIESVRRVGGKVLVHCIAGVSRSASLVIAYLM-----KYQRLNLRDAHKLVQDKRPLIRPN
..|.|.  .   ...  . .  ..|.. . ... .  || |.||| |||.|.. .....|.     | ..... .| | .  .|| . ..
rtvthfhytnwpdhgvpdspellldflrlvrkalasgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqt
0046845 (Phosphotyrosine protein) phosphatases II 78-140 2.5e-12 42.2 In-house 184-256 (284) alignment 
Range on Protein: 78-140
Range on HMM: 184-256/284.0
IGIFFDMVSDKIESVR--RVGGKVLVHCIAGVSRSASLVIAYLMKYQ--------RLNLRDAHKLVQDKRPLI
. ...... .  |. .    ||...||| |||.|.. .....|...|        .... .| | . ..||  
pedlleflrlvrellenlpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgm
0050432 (Phosphotyrosine protein) phosphatases II 82-142 6.1e-12 40.9 In-house 216-283 (308) alignment 
Range on Protein: 82-142
Range on HMM: 216-283/308.0
FDMVSDKIESVRRV--GGKVLVHCIAGVSRSASLVIAYLM-----KYQRLNLRDAHKLVQDKRPLIRP
.... | .| ||..  ||...||| |||.|.. .....|.     | ..... .| | .  .||   .
peilldflelvrkslpggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvq
0048567 (Phosphotyrosine protein) phosphatases II 80-153 1.4e-10 35.7 In-house 58-134 (157) alignment 
Range on Protein: 80-153
Range on HMM: 58-134/157.0
IFFDMVSDKIESVRRVGGKVLVHCIAGV---SRSASLVIAYLMKYQRLNLRDAHKLVQDKRPLIRPNTGFWKELIDY
 |. .. .......  |... ||| ||    .|.| |. .||....... ..| ....  || . |    .  | .|
rFilklnkflkilelagkaiavhckaglkkrgrtatLigcYlilhlgftpeeaiaplrivrpgsvpfrdasyllsly
subfamily_PTPDC1_pd Subfamily PTPDC1 63-139 1.7e-08 29.1 In-house 83-157 (182) alignment 
Range on Protein: 63-139
Range on HMM: 83-157/182.0
VKHIRIKVNDNPGNKIGIFFDMVsdKIESVRRVGGKVLVHCIAGVSRSASLVIAYLMKYQRLNLRDAHKLVQDKRPL
. .  .  .|   . .   .|.|  |. .     ||| ||| ||  |   |. .||.  .||.  .| |||..||| 
iyvynfgwkDygvasleriLdiv..kvvafalqegkvavhChaGlGrtGvliacylvyakrltaekaiklvrskrpk
PTPc_DSPc_SM00012 70-122 4.8e-08 28.5 In-house 15-65 (105) alignment 
Range on Protein: 70-122
Range on HMM: 15-65/105.0
VNDNPgNKIGIFFDMVSDKIESVRRvGGKVLVHCIAGVSRSASLVIAYLMKYQ
| ... ..|  ... | .. .   . .. |.||| |||.|.. .| ....  |
vPees.dsilellravkknknkses.skpvvVhCsaGvgRtgtfvaldillqq
subfamily_RNGTT_pd Subfamily RNGTT 54-151 9.4e-08 25.9 In-house 64-168 (189) alignment 
Range on Protein: 54-151
Range on HMM: 64-168/189.0
EAP-----EQDYKKVKHIRIKVN---DNPG-NKIGIFFDMVSDKIEsvRRVGGKVLVHCIAGVSRSASLVIAYLMKYQRLNLRDAHKLVQDKRPLIRPNT
. .     | . ...|.......   . |  ...  |  .|.. ..  ..    . |||  |  |.  |...||.. .  ....| .| .  ||    . 
tsryYdkeelekegikyvklqcagkgeaPeaeqvkefiklveeffk..knpeevigvhCthGfnRtGFlivsyLvekedwsveaavalFakaRppGiyke

GFWKELI
 . |||.
dylkell
subfamily_DSP23_pd Subfamily DSP23 36-138 1.1e-07 26.6 In-house 23-126 (148) alignment 
Range on Protein: 36-138
Range on HMM: 23-126/148.0
DEKLLLEKGITLVINATIEAPE--QDYKKVKHIRIKVNDNPGN---KIGIFFDMVsdkiESVRRVGGKVLVHCIAGVSRSASLVIAYLMKYQRLNLRDAH
. . ||..|.  ..  | |..   .   ..   |....|       ..  |  .|    |     .  | |||. |  |. ...  ||.| ..|   .| 
qyrylldlgvrylvslteegrphveatpnltlvrlriddyhppaleqvvefvrvv....eeaeekneavsvhcllgrgrtgtmlacylvkerklaaaeai

KLVQDKRP
  |. .||
aevrrlrp
subfamily_Laforin_pd Subfamily Laforin 95-140 2.2e-07 23.9 In-house 109-154 (183) alignment 
Range on Protein: 95-140
Range on HMM: 109-154/183.0
VGGKVLVHCIAGVSRSASLVIAYLMKYQRLNLRDAHKLVQDKRPLI
 | .| ||| ||| ||...|  .|.     .|.     .  ||| .
kghivyvhcnagvgrstaivcgflqyvlgwslakvqyfllakrpvv
subfamily_CDC14_pd Subfamily CDC14 89-131 6.2e-07 23.6 In-house 256-298 (328) alignment 
Range on Protein: 89-131
Range on HMM: 256-298/328.0
IESVRRVGGKVLVHCIAGVSRSASLVIAYLMKYQRLNLRDAHK
.| . .. |.. ||| ||. |  .|. .||||  |..  .|  
leiaekaeGaiavhCkaGLGrtGtLiacylmkhyrftaaeaia
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 51-125 3.6e-06 20.9 In-house 176-248 (305) alignment 
Range on Protein: 51-125
Range on HMM: 176-248/305.0
ATIEAPEQDYKKVKHIriKVNDNPGNKIGIFFDMVSDKIESVRRVGGKVLVHCIAGVSRSASLVIAYLMKYQRLN
 .|| | .. .||.|   . .| |   .      . . .|  |   | . ||| ||. |. |.|.   .  | |.
lviegpgekarkvthy..hwidwpdrgvpaadlailellekarpskgpivvhcsagigrtgsvvmleyildqlla
subfamily_DSP11_pd Subfamily DSP11 59-137 3.7e-06 20.9 In-house 81-157 (178) alignment 
Range on Protein: 59-137
Range on HMM: 81-157/178.0
DYKKVKHIRIKVndNPGNKIGIFFDMVSDKIESVRRVGGKVLVHCIAGVSRSASLVIAYLMKYQRLNLRDAHKLVQDKR
 |.|..    .|  .  . .  | ..|.. .|.    .  . |||  || |.  |.  ||.. . .. .|| .  .. |
kylklncpGhev..pkeelvkkfkeavkefleknkdndkligvhCthGvnrtGyliCrylidvegyepedaieafeear