Gene DSP15 in Nematostella vectensis

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family DSP
Subfamily DSP15
Protein sequence
ID Type Fasta BLAST phosphatome Note
NvecP009_AA protein Get Run
NvecP009_AA_2-143 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_DSP15_pd Subfamily DSP15 4-143 1.4e-73 240.0 In-house 1-140 (151) alignment 
Range on Protein: 4-143
Range on HMM: 1-140/151.0
GMNKIIPGLYLGNIRDSKDAEQLQEHNITHILSIHDNANPLREDIMYKCIHAADSPDQDLMPFFQECIEFIHSCRVKEMNCLVHCIAGISRSTTICAAYI
|..|..|||||||.|||||.|.|.|.|||||||.||||..|..||.||||.|.|.|...|. ||.|..||||.||.||.|.||||.||.|||.|...||.
giskvlpglylgnfrdskdeelLkeknithilsvhdnakkllkdieYkciaasDtpsaklskffkesvefihkcRlkeenvlvhClaGvsRsvtlvvaYl

MTITELSWRQTLQAIRANRSIANPNYGFKRQLQDFYNKHL
||.|||.||..|..|.|.||.||||.||||||... ...|
mtvtelnwrdalevikaaRsvanPnfGfkrqlkeyektkl
subfamily_DSP12_pd Subfamily DSP12 5-140 1.4e-40 133.3 In-house 2-141 (155) alignment 
Range on Protein: 5-140
Range on HMM: 2-141/155.0
MNKIIPGLYLGNIRDSKDAEQLQEHNITHILSIHDNA----NPLREDIMYKCIHAADSPDQDLMPFFQECIEFIHSCRVKEMNCLVHCIAGISRSTTICA
...| ||||||.... .. |.|.| .|||.||.  ..    .. .  . .| |...|.|..|.. ...|...||.... .| . |||| ||.||| ||..
vsrilpglylggleavqeeellkelkithvlsvikeelpehklkkgkvstkfiqilDepeediLshldeavdFieealeeegavlvHCqagvSRSvtivi

AYIMTITELSWRQTLQAIRANRSIANPNYGFKRQLQDFYN
||.|  ..||  . |..... .. ..|| || .||. |..
AYlmkkeklslekAlklvkekkpeiepNegFleQLklfek
subfamily_DSP19_pd Subfamily DSP19 6-139 1.6e-39 129.7 In-house 13-147 (152) alignment 
Range on Protein: 6-139
Range on HMM: 13-147/152.0
NKIIPGLYLGNIRDSKDAEQLQEHNITHILSIHDNA-NPLREDIMYKCIHAADSPDQDLMPFFQECIEFIHSCRVKEMNCLVHCIAGISRSTTICAAYIM
 ...| |||| .   .| |.|.|..|||||..  .  |   .|. |..|.  | |..||. ...|...||.. | |.   |||| ||.|||...  ||.|
geveprlylgsqdvaadkeilkekkitHilnvatgvpnvfpkdftylsieilDlpetdllsylkealdFieearskdgavlvHCnAGvSRsasvviaylm

TITELSWRQTLQAIRANRSIANPNYGFKRQLQDFY
. .||| ...|. .|. |  ..|| || .||... 
kkeelsleealelvrearpcikPneGFikqLkeye
0044763 (Phosphotyrosine protein) phosphatases II 3-142 3.9e-38 126.2 In-house 21-170 (178) alignment 
Range on Protein: 3-142
Range on HMM: 21-170/178.0
NGMNKIIPGLYLGNIRDSKDAEQLQEHNITHILSIHDN----------ANPLREDIMYKCIHAADSPDQDLMPFFQECIEFIHSCR-VKEMNCLVHCIAG
.....|.||||||.  ...| |.|.|..||||... ..            | ...| |..|.  |....||. .|.|..|||....  |. ..|||| ||
inaseilpglylgslppaddlellkelgithivnlteelelgflkcdpywpeeagiqylhipipDhgvpdllehflefvefieealdekggpvlVHCsaG

ISRSTTICAAYIMTITELSWRQTLQAIRANRSiANPNYGFKRQLQDFYNKH
..||.|..|||.|    ||. . .. .|. |. ..|| |. |||..|. ..
vgRsgtlvaaylmkklglsleeaielvrerRp.ivpnpgqlrqLyefelrl
PTPc_motif_SM00404 5-141 5.1e-38 125.1 In-house 2-140 (140) alignment 
Range on Protein: 5-141
Range on HMM: 2-140/140.0
MNKIIPGLYLGNIRDSKDAEQLQEHNITHILSIHDNANP--LREDIMYKCIHAADSPDQDLMPFFQECIEFIHSCRVKEMNCLVHCIAGISRSTTICAAY
...| |.||||..........|....|||.... .. .     ... ...|   |.  ..| ........||.... |. ..|||| ||.||| |...||
psrilphlylgskskaqnpallkklgithvinvteevsltkensgfqilqiplddnekdklskyldkvldfienaekkggkvlVHCqaGvSRSatliiaY

IMTITELSWRQTLQAIRANRSIANPNYGFKRQLQDFYNK
.|.  .||... ..... .|.| .|| .|.|||.....|
lmryrqlslaeayefvkerRpiispnlnfvrqLieyekk
subfamily_DSP1_pd Subfamily DSP1 6-143 7.8e-38 124.1 In-house 19-157 (163) alignment 
Range on Protein: 6-143
Range on HMM: 19-157/163.0
NKIIPGLYLGNIRDSKDAEQLQEHNITHILSIHDNA-NPLREDIMYKCIHAADSPDQDLMPFFQECIEFIHSCRVKEMNCLVHCIAGISRSTTICAAYIM
.||.. ||||   .. . |.|....||.|| .  .  |  ..   ||...  |||..|..  |.| ||||.... |.   |.|| ||||||.|.| ||.|
ekildfLylGsetvasnleiLkslgitailnvskeldnvfedlfeYkklkleDspkadislvfeeviefidevkkknGkvlihCqaGisRsstlclaylm

TITELSWRQTLQAIRANRSIANPNYGFKRQLQDFYNKHL
. ...|  .  . .. .||| .|| ||..|| .. .| |
ktkrvsleeafdfvkqrRsiisPnagFvlqLlnyekkll
subfamily_DSP6_pd Subfamily DSP6 7-140 5.7e-37 120.7 In-house 16-152 (158) alignment 
Range on Protein: 7-140
Range on HMM: 16-152/158.0
KIIPGLYLGNIRDSKDAEQLQEHNITHILSIHDN-ANPL--REDIMYKCIHAADSPDQDLMPFFQECIEFIHSCRVKEMNCLVHCIAGISRSTTICAAYI
.|.| ||||. .|... | |....| ..| .  |  |     ... |. | . |   |.|. || | ||||   | |. ..||||.|||||| |.. ||.
eilpllylGsakdasnlevlkklkikyvlnvtsnlpnkfeesgelkylqipiedhlsqnlakffPeaiefidearskkskvlvhClaGisrsvtvtlayl

MTITELSWRQTLQAIRANRSIANPNYGFKRQLQDFYN
|  ..||  .. . ... .|   ||. |  || || .
mkklalslndaydlvkkrksnisPnfnfmgqlldfer
0048076 (Phosphotyrosine protein) phosphatases II 4-141 3.3e-36 119.5 In-house 3-141 (145) alignment 
Range on Protein: 4-141
Range on HMM: 3-141/145.0
GMNKIIPGLYLGNIRDSKDAEQLQEHNITHILSI-HDNANPLREDIMYKCIHAADSPDQDLMPFFQECIEFIHSCRVKEMNCLVHCIAGISRSTTICAAY
....|.||||||.. . .| |.|....||..|.. ..  .. |..| | ..   | . .||. ...|..|||.... .. ..|||| ||..|..|..|||
wpseilpglylgslptaldlellkdlgittvlnltselellerlgiqylylpwpDhgvpdllellleflefieealkeggpvlVHCsaGvgRtgtlvaay

IMTITELSWRQTLQAIRANRSIANPNYGFKRQLQDFYNK
.|    .|. ..|. .|. |..|.|| |. |.|..|. .
lmlllgvsleealelvrsqrpgavpnpgqlrflyefele
0048179 (Phosphotyrosine protein) phosphatases II 3-140 1e-35 117.9 In-house 2-142 (144) alignment 
Range on Protein: 3-140
Range on HMM: 2-142/144.0
NGMNKIIPGLYLGNIRDSKDAEQLQEHNITHILSI---HDNANPLREDIMYKCIHAADSPDQDLMPFFQECIEFIHSCRVKEMNCLVHCIAGISRSTTIC
. ...|.||||||.. ...| |.|....||.....   .... . || | | ..   | .  ||. ...|..|||.... .. ..|||| ||..|..|..
snpseilpglylgslptaldlellkklgittvinlteeyepefleregiqylhlpwpDhgvpdllellleflefieealeeggpvlVHCsaGvgRtgtlv

AAYIMTITELSWRQTLQAIRANRSIANPNYGFKRQLQDFYN
|||.|    ||. ..|. .|. |..|.|| |. |.|.....
aaylmkklglsleealalvrsrrpgavpnpgqlrfLleyek
subfamily_DSP10_pd Subfamily DSP10 5-140 1.3e-35 116.6 In-house 14-151 (159) alignment 
Range on Protein: 5-140
Range on HMM: 14-151/159.0
MNKIIPGLYLGNIRDSKDAEQLQEHNITHILSIHDNANPLRE--DIMYKCIHAADSPDQDLMPFFQECIEFIHSCRVKEMNCLVHCIAGISRSTTICAAY
. ...| |.||. .|..| . |...|||..| .  .     |  .. || | . |.  |.|   |.| .|||.  | |. . |||| ||||||.|.  ||
asqvlpfLflGsekdaadldaldrlnitavlnvttsvPnefeeealkYkripvsDtskqnlkqyfeealefieearkkgsrvLvhCqaGisrsatvviaY

IMTITELSWRQTLQAIRANRSIANPNYGFKRQLQDFYN
.|. ..|| ..  . .. .|.|  || .|  || .| .
lmkhlnlslndaykfvkekrpiisPnLnfmGqLlefek
0043147 (Phosphotyrosine protein) phosphatases II 5-140 9.1e-35 115.3 In-house 19-158 (172) alignment 
Range on Protein: 5-140
Range on HMM: 19-158/172.0
MNKIIPGLYLGNIRDSKDAEQLQEHNITHILSIHD----NANPLREDIMYKCIHAADSPDQdLMPFFQECIEFIHS--CRVKEMNCLVHCIAGISRSTTI
....|.......  .... ..|.|..||||... .      .  |..| | ..   | . . |. ...|..|||..  .. ..  .|||| ||..|. |.
pdrfiatqgplrntladfwrmlkelgithivnltellydpellerlgiqylylpwpDhgvp.llellleflefidellalspggpvlVHCsaGvgRtgtl

CAAYIMTiTELSWRQTLQAIRANRSIANPNYGFKRQLQDFYN
.|||.|    ||. .... .|. |..| .| .. |.|..| .
vaaylml.lglsleeavalvrekRpgavqnpsqyrflyyfek
subfamily_DSP14_pd Subfamily DSP14 4-141 1e-33 110.5 In-house 6-143 (157) alignment 
Range on Protein: 4-141
Range on HMM: 6-143/157.0
GMNKIIPGLYLGnIRDSKDAEQLQEHNITHILSIH-DNANPLREDIMYKCIHAADSPDQDLMPFFQECIEFIHSCRVKEMNCLVHCIAGISRSTTICAAY
....| | |.|.  . ... |.|....||.|. .  .  |.  .|| .  . ..|.|...|...|.| .. |.. . |. ..||||.||.||| ..| ||
alsqitpsLfls.gvaalskellkkkkitliinvtvelpntklkdiervkvpveDnpeaklakhfdevadkieevkkkggktlvhCvaGvSRSAslclay

IMTITELSWRQTLQAIRANRSIANPNYGFKRQLQDFYNK
.|   .|| |.. ..... |.| .|| || .||.|. .|
lmkyeklsLreayklvksaRpiirPNvGFwkqlidyEkk
DSPc Dual specificity phosphatase, catalytic domain 12-140 1e-32 107.8 Pfam-A 1-132 (133) alignment 
Range on Protein: 12-140
Range on HMM: 1-132/133.0
LYLGNIRDSKdAEQLQEHNITHILSIHDNANP----LREDIMYKCIHAADSPDQDLMPFFQECIEFIHSCRVKEMNCLVHCIAGISRSTTICAAYIMTIT
||||.  ...  ..|....||..... .. .       ..| | .|   |. .... ....|..|||.... |. ..|||| |||||| |...||.|.  
lylgskstas.lalleklgitlvinvtkevpnnnaikkseieylripvedetetkiskeleeavefiekaeqkgkkvlVHCqaGisRSatliiaYlmktk

ELSWRQTLQAIRANRSIANPNYGFKRQLQDFYN
.|| .. ..... .||. .|| ||.||| ....
nlslneAyefvkerrskispnagflrqLleyer
DSPc Dual specificity phosphatase, catalytic domain 12-140 1e-32 107.8 In-house 1-132 (133) alignment 
Range on Protein: 12-140
Range on HMM: 1-132/133.0
LYLGNIRDSKdAEQLQEHNITHILSIHDNANP----LREDIMYKCIHAADSPDQDLMPFFQECIEFIHSCRVKEMNCLVHCIAGISRSTTICAAYIMTIT
||||.  ...  ..|....||..... .. .       ..| | .|   |. .... ....|..|||.... |. ..|||| |||||| |...||.|.  
lylgskstas.lalleklgitlvinvtkevpnnnaikkseieylripvedetetkiskeleeavefiekaeqkgkkvlVHCqaGisRSatliiaYlmktk

ELSWRQTLQAIRANRSIANPNYGFKRQLQDFYN
.|| .. ..... .||. .|| ||.||| ....
nlslneAyefvkerrskispnagflrqLleyer
0049260 (Phosphotyrosine protein) phosphatases II 5-140 1.6e-31 104.5 In-house 8-147 (152) alignment 
Range on Protein: 5-140
Range on HMM: 8-147/152.0
MNKIIPGLYLGNIRDSKDAEQLQEHNITHILSIHDNANP----LREDIMYKCIHAADSPDQDLMPFFQECIEFIHS-CRVKEMNCLVHCIAGISRSTTIC
....|.....|.   ... ..|.|..||.|... .          . | |...   |.. .||  .......||.  .. |. ..|||| ||..|. |..
pfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyiqylhlpwpDhgvpdlsqlllflllfieklaldkggpvlVHCsaGvgRtgtlv

AAYIMTiTELSWRQTLQAIRANRSIANPNYGFKRQLQDFYN
|||.|    .|. .... .|. |..|.|| |. |.|..|..
aaylml.lgvsleeavalvrekRpgavpnpgqlrflyefek
0041856 (Phosphotyrosine protein) phosphatases II 4-139 1.7e-31 104.6 In-house 18-169 (182) alignment 
Range on Protein: 4-139
Range on HMM: 18-169/182.0
GMNKIIPGLYLGNIRD--------------SKDAEQLQEHNITHILSIHDNA----NPLREDIMYKCIHAADSPDQDlmpfFQECIEFIHSCRVKEMNCL
....| ..||||. ..               .. ..|.|..||.|... .      .  |. | |...   | .  |    ..|...||. .. .. ..|
dldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlteelywpellerlgiqylylpwpDhgvpd....ldelldfieevleeggpvl

VHCIAGISRSTTICAAYIMTITELSWRQTLQAIRANRS--IANPNYGFKRQLQDFY
||| ||..|. |..|||.|   ..|...... .|  |.  . .||..| .||. ..
VHCsaGvgRtgtlvaaylmkklgvsleeavklvrsrRpgmvitpnqyfflqlalle
subfamily_LRR-DSP_pd Subfamily LRR-DSP 6-141 2.4e-30 99.5 In-house 121-257 (263) alignment 
Range on Protein: 6-141
Range on HMM: 121-257/263.0
NKIIPGLYLGNIRDSKDAEQLQEHNITHILSIHDNANPLREDI-MYKCI-HAADSPDQDLMPFFQECIEFIHSCRvKEMNCLVHCIAGISRSTTICAAYI
..||..|.||    ....  |.. ..||||    . .||  ..  |  | .. | .. |.  .|.|   ||.. | |.   |||| ||.|||.|.  .|.
deiidklflGgldsannksilkdlgvthillavadfePlfPklfkylsiddiedvdeadisqhfeetnafieeGr.kkGGvlvhcraGvsrsstlvisyl

MTITELSWRQTLQAIRANRSIANPNYGFKRQLQDFYNK
|   .| ....|  .  .|.  .|| ||| ||. . .|
mkkqrlkfkealdlvikkrpriqPnpGfkdqlkkyekk
0046846 (Phosphotyrosine protein) phosphatases II 3-142 5.8e-30 99.7 In-house 10-172 (176) alignment 
Range on Protein: 3-142
Range on HMM: 10-172/176.0
NGMNKIIPGLYLGNIR----------DSKDAEQLQEHNITHILSIHDN------------ANPLREDIMYKCIHAADSPDQDLmPFFQECIEFIHSCRVK
.... |...|.||.              .. |.|.|..||..... .                 ...| |....  |    ||   ..|..|||.... .
ldldyinanlilgsrpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgiqylhlpwpDhgvpdl.elllellefirealke

EMNCLVHCIAGISRSTTICAAYIMTI-TELSWRQTLQAIRANRS-IANPNYGFKRQLQDFYNKH
  . |||| |||.|. |..|||..     ||. ..|. .|. |.  | .. .. |.|..|. ..
ggpvlVHCsaGigRtgtlvaayllelekglsveealalvreqRplgavqtpeQyrflyefelll
0049772 (Phosphotyrosine protein) phosphatases II 4-142 1.4e-29 99.2 In-house 125-273 (314) alignment 
Range on Protein: 4-142
Range on HMM: 125-273/314.0
GM---------------------NKIIPGLYlgNIRDSKDAEQLQehnithilSIHDNANPLRED-IMYKCIHAADsPDQDLMPFFQECIEFIHSCrVKE
.|                     . |..|..  |. . .| |.|.        ....... . .  | |..|.  | ....|  .|.|..|||...  |.
vmsrdevladelsrLdaAlgKtpllildgng..neptaadlellk........eelydpelferlgikylripvpD.gsaplledfdeflefieea.dkg

MNCLVHCIAGISRSTT-ICAAYIMTITELSWRQTLQAIRANRSiANPNYGFKRQLQDFYNKH
 . |||| ||..|..| ..|||.|    .|....|. .|. |. .||| || .||.......
gpvlvHCkaGkgRtgtfvvaaylmkllgvsleealedvrlkRp.inpnpgfieqleqyefil
0037934 (Phosphotyrosine protein) phosphatases II 5-141 2.7e-29 97.8 In-house 39-240 (243) alignment 
Range on Protein: 5-141
Range on HMM: 39-240/243.0
MNKIIPGLYLGNI--------RDSKDAEQLQEHNITHILSIHD----------------------------------------------NANPLREDIMY
. .. |.|....         .. .. . |.|..||.|... .                                                .. |..| |
liyvtprliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywpgevtygdftvtllseehlddytvrtlllenldlddltrlvihy

KCIHAAD----SPDQDLMPFFQECIEFIHS-----CRVKEMNCLVHCIAGISRSTTICAAYIMTIT-ELSWRQTLQAIRANRSI-ANPNYGFKRQLQDFY
 ..   |    .  .||. |..|..|||..     .. ..  .|||| ||..|. |..|||.|    .... .... .|. |.  | ..... |.|....
hylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRtGtliaaylmllllgvdleeavkllreqRpgkavqtpsqyrflyeal

NK
 .
le
0045098 (Phosphotyrosine protein) phosphatases II 5-142 2.9e-29 97.8 In-house 22-271 (278) alignment 
Range on Protein: 5-142
Range on HMM: 22-271/278.0
MNKIIPGLYLGNIR-----------------------------------------DSKDAEQLQEHNITHILSI--------------------------
...| |.|||||.                                           ... ..|.|..||.|...                          
pseitpalylgnldknRykdilpydhsrVkdYINAsyidgypkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrekcaqywpeggsltygdf

---------------------------HDNANPLREDIMYKCIHAADSPDQDLMPFFQECIEFIHSCRV--------------KEMNCLVHCIAGISRST
                           .|. .   . . |...   ..|..... .|.|..|||....               ..  .|||| ||..|. 
tvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsggpvlVHCsaGvgRtG

TICAAYIMTIT---ELSWRQTLQAIRANRSI-ANPNYGFKRQLQDFYNKH
|..|||.|       ... .... .|  | . | .| .. |.| .|  ..
tlvaaylmlelleggvdlleavkelrsqRpglavqnleqyrflyefllel
subfamily_Slingshot_pd Subfamily Slingshot 6-138 1.4e-28 93.4 In-house 20-153 (169) alignment 
Range on Protein: 6-138
Range on HMM: 20-153/169.0
NKIIPGLYLGNIRDSKDAEQLQEHNITHILSIHDNA-NPLREDIMYKCIHAADSPDQDLMPFFQECIEFIHSCRVKEMNCLVHCIAGISRSTTICAAYIM
 ||   .|||   .. . |.|.|.....|| .  .  |   |.. |. |.  |....||.....|  .||. .. |. ..||||  |.|||...  || |
skifdhvylGsewnasnleelkengveyilnvtkeidnffpekfeylnirvydeeetdllkywnetykfiekakkkgskvlvhckmGvsrsastviayam

TITELSWRQTLQAIRANRSIANPNYGFKRQLQDF
   .||  ..|. .. .||...|| || .||. .
keyglsleealeyvkerrsvikPnkgflkqleey
subfamily_DSP8_pd Subfamily DSP8 4-141 1.7e-28 93.2 In-house 14-153 (159) alignment 
Range on Protein: 4-141
Range on HMM: 14-153/159.0
GMNKIIPGLYLGNIRDSKDAEQLQEHNITHILSIHDNA---NPLREDImYKCIHAADSPDQDLMPFFQECIEFIHSCRVKEMNCLVHCIAGISRSTTICA
|...|.. ||||  .|. . | |.. .|...| .  .    . |.|.  .  .   |. | .|.|.|.. .|||  .. .. ..|||. ||||||.|.  
gptrilknlylGsqkdvlseellsklgisyvlnasnscpkleelkesk.flrvPvkDkydekllpwfdksvefidkaksengrvlvhvlaGisrsatvai

AYIMTITELSWRQTLQAIRANRSIANPNYGFKRQLQDFYNK
||||   |.|  .. . ..  |   .||. |  || .....
ayimktlemsldeayrfvkekrptispnlnflgqLleyeke
subfamily_DSP3_pd Subfamily DSP3 4-141 1.9e-28 93.2 In-house 10-156 (162) alignment 
Range on Protein: 4-141
Range on HMM: 10-156/162.0
GMNKIIPGLYLGNIRDSKDAEQLQEHNITHILSIHDN--------ANPLR-EDIMYKCIHAADSPDQDLMPFFQECIEFIHSCR-VKEMNCLVHCIAGIS
 .. . |.||.|.   .|| ..|..  |||.|   .         |.  .  .| |  ... |.|  ||  .|..  .||..    ||   |||| .|.|
evdevypklyvgdeavakdkskLkklGithvlnaaegrfskvdtgaefykdleikylGlevdDvpefdlskyFetaakfidealsqkegkvlvhcvvGvs

RSTTICAAYIMTITELSWRQTLQAIRANRSIAnPNYGFKRQLQDFYNK
||.|.  ||.|   ...  . ....|..|.|  || || .||... ..
RsatlvlayLmirrkmtlveairtvrkkReil.PneGFlkqLaeldee
PTEN_1 7-143 7.2e-28 92.7 In-house 43-192 (196) alignment 
Range on Protein: 7-143
Range on HMM: 43-192/196.0
KIIPGLYLGNIRDS-KDAEQLQEHNITHILSIHDNANP----------LREDIMYKCIHAADSPDQDLMPFFQECIEFIHSCRV--KEMNCLVHCIAGIS
.|..|||.|...|  .| ..|.|..||....  .  .            .....|. ..  | . ..|  .| .| .||....   .. ..|||| ||..
eideglyrgslkdvaadldnlkedgitlvvnlseeeelsgrsydleeffksgveylhfpieDhgapslselfdicksfiewllsdpngnvVlVHCkaGlg

RSTTICAAYIMTITELSWRQTLQAIRANRSIANPNYGFKRQLQDFYNKHL
|| |..||| |    |. ...|. .|. |. ..|| .. ..|. .... |
RsGtvvaayLmykgkltadeAlelvrekRppgapnspsqerlleyfaell
0040439 (Phosphotyrosine protein) phosphatases II 22-142 7.8e-28 93.1 In-house 70-245 (249) alignment 
Range on Protein: 22-142
Range on HMM: 70-245/249.0
DAEQLQEHNITHILSIHDNAN--------------------------------------------PLREDIMYKCIHAADSPDQDLMPFFQECIEFIHSC
. ..|.|..||.|... .                                                  |......|.  | ||... |.|.....||. .
fwrmlwelgitvivmLtslvelgrekcaqywplggsleygdftvtllsvevkddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldfieav

RV------KEMNCLVHCIAGISRSTTICAAYIM-----TITELSWRQTLQAIRANRSIANPNYGFKRQLQDFYNKH
|       |.  .|||| ||..|. |..|||.|     .  ...  .... .|  |. | .|... |.|...  ..
rkaleelpkggpvlVHCsaGvgRtGtfiaaylmleqlekelgvdleeavkllrsqRpgavqnpeqyrflyeallel
0045450 (Phosphotyrosine protein) phosphatases II 24-142 1.3e-27 92.8 In-house 125-303 (307) alignment 
Range on Protein: 24-142
Range on HMM: 125-303/307.0
EQLQEHNITHILSIHDNANP-----------------------------LREDIMYKCIHAADS-----------------PDQDLMPFFQECIEFIHSC
..|.|...|.|... .                                   ... . ...  |.                 ||... |.|.|...||. .
rmlweqgvtvivmltelvelgrekcaqywPdegeeltygnftvtllseehldgytvrtlevtdldgtgesrtvthfhytgwpdhgvppsfeelldfieev

RV------KEMNCLVHCIAGISRSTTICAAYIMTITE--------LSWRQTLQAIRANRSIANPNYGFKRQLQDFYNKH
|       |.  .|||| ||..|. |..|||.|            ........ .|. |. | .|... |.|...  ..
rkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyeallel
0042113 (Phosphotyrosine protein) phosphatases II 6-140 1.1e-25 86.0 In-house 48-240 (245) alignment 
Range on Protein: 6-140
Range on HMM: 48-240/245.0
NKIIPGLYLGNIRDSKDAE----QLQEHNITHILSIHD-----------------------------------------------NANPLREDIMYKCIH
 .| |......   ... |    .|.|..||.|... .                                                 .. ||.| | ...
yritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywplgesltygdftvtllseehlddytvrtlevtnlgddesrevihyhylp

AADSPDQDLMPFFQECIEFIHSCRV--KEMNCLVHCIAGISRSTTICAAYIM-----TITELSWRQTLQAIRANRSIANPNYGFKRQLQDFYN
  | .  ||.  .....||.....   ..  .|||| ||..|. |..|||.|     .  ..|. .... .|  |. | .. .. |.|...  
wpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylmleqlekelgvsleeavkelrsqRpgavqtpsqyrflyeall
subfamily_STYX_pd Subfamily STYX 4-144 1.9e-25 82.9 In-house 11-159 (166) alignment 
Range on Protein: 4-144
Range on HMM: 11-159/166.0
GMNKIIPGLYLGNIRDSK--DAEQLQEHNITHILSIHDNAN------PLREDIMYKCIHAADSPDQDLMPFFQECIEFIHSCRVKEMNCLVHCIAGISRS
 |..|.|||.||    ..    |.|..| ||||. | .| .       ......|  .  ||.. .... .. .  ||| ..  |  . |||  ||||||
emqeilpglflgpysaamksklevlkkhgithivcirqnieanlikpnfpdrfrylvldvadntveniirylptvkefiddslqkggkvlvhgnagisrs

TTICAAYIMTITELSWRQTLQAIRANRSIANPNYGFKRQLQDFYNKHLT
...  ||||    | .|.. . .. .|   ||| || .||...   .|.
aalviayimetyglkyreafayvqerrfcinpnegfvsqlkeyeaiyla
0036282 (Phosphotyrosine protein) phosphatases II 5-138 2.1e-25 84.8 In-house 12-165 (174) alignment 
Range on Protein: 5-138
Range on HMM: 12-165/174.0
MNKIIPGLYLGNIRDSkDAEQLQEHNITHILSIHDNANP----------------LREDIMYKCIHAADSPDQDLMPfFQECIEFIHSCRVK--EMNCLV
.. | |.|..|.   . . |.|.|..||....  .   .                 |..| |....  |    ||   ..|...|..... .  .  .||
lsyitprliagqgpla.fwemlkelgittvvmlleekelglykcinywpelredlerlgiqylylpwpDhgvpdlsi.llefvkfveealsedpggpvlV

HCIAGISRSTTICAAYIMTITEL-SWRQTLQAIRANR---SIANPNYGFKRQLQDF
|| ||..|. |..|||.|    | | .. |. .|. |   . . .. .. |.|..|
HCsaGvgRtGtlvaaylmlrglleslvdaldlvrelRlqrpgmvqtpsQyrflyyf
subfamily_MKPLT_pd Subfamily MKPLT 12-145 2.8e-24 79.5 In-house 29-163 (164) alignment 
Range on Protein: 12-145
Range on HMM: 29-163/164.0
LYLGNIRDSKDAEQLQEHNITHILSIH-DNANPLREDIMYKCIHAADSPDQDLMPFFQECIEFIHSCRVKEMNCLVHCIAGISRSTTICAAYIMTITELS
|||||  ...... |.. .||||. .  ....   . . |  ..  | .|. |..|..   .|. .        ||||  | |||...  |....     
lylGnakhatnekvlkdlkithivnvsqekkdafpksveYlqvkvedesdeqlssfleraakfladaidsGGrvlvhcvqGksrsssvtvafLikskgwt

WRQTLQAIRANRSIANPNYGFKRQLQDFYNKHLTK
 ... . ..  |||..|| || .||  | .  | |
lkeayeylkerrsivapnrGflkqlakfeelilGk
subfamily_MKPLV_pd Subfamily MKPLV 12-145 2.8e-24 79.5 In-house 29-163 (164) alignment 
Range on Protein: 12-145
Range on HMM: 29-163/164.0
LYLGNIRDSKDAEQLQEHNITHILSIH-DNANPLREDIMYKCIHAADSPDQDLMPFFQECIEFIHSCRVKEMNCLVHCIAGISRSTTICAAYIMTITELS
|||||  ...... |.. .||||. .  ....   . . |  ..  | .|. |..|..   .|. .        ||||  | |||...  |....     
lylGnakhatnekvlkdlkithivnvsqekkdafpksveYlqvkvedesdeqlssfleraakfladaidsGGrvlvhcvqGksrsssvtvafLikskgwt

WRQTLQAIRANRSIANPNYGFKRQLQDFYNKHLTK
 ... . ..  |||..|| || .||  | .  | |
lkeayeylkerrsivapnrGflkqlakfeelilGk
0040438 (Phosphotyrosine protein) phosphatases II 25-143 7e-24 80.1 In-house 105-276 (317) alignment 
Range on Protein: 25-143
Range on HMM: 105-276/317.0
QLQEHNITHILSIHDNANP----------------------------LREDIMYKCIHAADS----------------PDQDLMPFFQECIEFIHSCRVK
 ..|...|.|... .   .                              ..| . ...  |.                ||... | ......|.. .| .
mvweqgvtvivmLteleelgrekcaqYwplgetltygdftvtllseeelagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfleavrea

----EMNCLVHCIAGISRSTTICAAYIM-----TITELSWRQTLQAIRANRSIANPNYGFKRQLQDFYNKHL
    .  .|||| ||..|. |..|||.|     .  .... .... .|. |. | ..... |.| |. ...|
ledpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalleyl
subfamily_Choan-DSP_MKP-1_pd Subfamily Choan-DSP_MKP-1 12-139 9.8e-24 77.6 In-house 15-144 (148) alignment 
Range on Protein: 12-139
Range on HMM: 15-144/148.0
LYLGNIRDSKDAEQLQEHNITHILSIH-DNANPLRED-IMYKCIHAADSPDQDLMPFFQECIEFIHSCRVKEMNCLVHCIAGISRSTTICAAYIMTITEL
|.||. .   |.|.|.. ..|.| .   .  |.| .  | |  .  .| |..||  .|.. |.|..  . .   .|||.  |.|||. .  ....   . 
LFlGskksaadlealkalgvtrivnatkerdnaldqrgieYlhvaldDkpkedlsaiFediiafvrkakdeGrrvLvhlqmGvsrssalallwlidfkrv

SWRQTLQAIRANRSIANPNYGFKRQLQDFY
| .. |.... .|   .|| || .||... 
slkealalvkskrryvdpnlgfLkqLaele
0051082 (Phosphotyrosine protein) phosphatases II 5-139 1.4e-23 78.6 In-house 8-150 (151) alignment 
Range on Protein: 5-139
Range on HMM: 8-150/151.0
MNKIIPGLYLGNIRDSKDAEQLQEHNITHILSIHD------NANPLRE-DIMYKCIHAADSPDQDLMPFFQECIEFIHSCRVK-EMNCLVHCIAGISRST
.. . .|||...   . . |.|.|..|..|... .      ....|.| .| ...|.  | ||..|  .|....||.. .. | . ..|||| ||..|. 
fsyvtgglyrsggpladflellkelgiktivnlrseeergycpeylpelgievlhipildwpdpglplsfdavleflellldkkngpvlvHCsaGkgRTG

TICAAYIMTiTELSWRQTLQAIRANRS-IANPNYGFKRQLQDFY
|..|.|.|    .|. ..|. .|. |  . .|| .|  ||....
tlvalylml.lgvsleealeeyrlkrpgvvqpnqqflfqlfall
subfamily_Dicty-DSP19-like_pd Subfamily Dicty-DSP19-like 8-141 2.8e-22 72.7 In-house 6-151 (154) alignment 
Range on Protein: 8-141
Range on HMM: 6-151/154.0
IIPGLYLGNIRDSKDAEQLQEHNITHILSI-HDNANPLRED---------IMYKCIHAADSPDQDLMPFFQECIEFIHSCR--VKEMNCLVHCIAGISRS
    ||..    . .  .||..||..|| .     | . ..         | |  ..  | ...|..  .. . |||..    |.. . |||. .|.|||
eaiflyissfdaalnkldlqlkniksilnvgiGinnlftdensdindgfiieylnlelfddvnfdiiekldkafefiddaiggvennkvlvhsdkGvsrs

TTICAAYIMTITELSWRQTLQAIRANRSIANPNYGFKRQLQDFYNK
...  .|.|   ..|. ..|. ..  | | .|| || .||. |  .
aallisylmdklkislslalellkdsryiikPnqGflkqleifeke
0039614 (Phosphotyrosine protein) phosphatases II 25-143 1.3e-21 72.8 In-house 120-289 (297) alignment 
Range on Protein: 25-143
Range on HMM: 120-289/297.0
QLQEHNITHILSIHDNA-------------------------------------------NPLREDIMYKCIHAADSPDQDLMPFFQECIEFIHSCRV--
 ..|...|.|... .                                             .. |.  .. ...  |    ...  ..| .|......   
mvweqgvtvivmLtklvelgrkcaqywpeeggtygdftvtllkvehldgytvrtlevtnngesrtvthfqytgwpdhgvppslellleflelvrealael

-KEMNCLVHCIAGISRSTTICAAYIM-----TITELSWRQTLQAIRANRSIANPNYGFKRQLQDFYNKHL
 |.  .|||| ||..|. |..|||.|     .  .... .... .|  |. | .. .. |.|.|.  ..|
pkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydallell
0036941 (Phosphotyrosine protein) phosphatases II 8-143 1.1e-20 69.5 In-house 22-277 (297) alignment 
Range on Protein: 8-143
Range on HMM: 22-277/297.0
IIPGLYLGNIRDSKDAEQLQ----------------------------------------------------------EHNITHILSIHDNAN-------
. | |.||... ..  | |.                                                          |.|.|.|... .          
llpllllgslsvallpenleknRykdilpydhtRVklddegsdYinAsyvdgydlkrkfIatqgPlpntvedFWrmvweqnvtvIvmltelvelgrekca

-----------------------------------------PLREDIMYKCIHAADSPDQDLMPFFQECIEFIHSCRV------KEMNCLVHCIAGISRS
                                            |  . . .|  . || .. . ......||. .|       ..   |||| ||..||
qywpleegesltygdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfielvrkvlkllpsggpvlVHCsaGvgRs

TTICAAYIM--------TITELSWRQTLQAIRANRSIANPNYGFKRQLQDFYNKHL
 |..||..|        .  ...  .... .|  |  | ..... |.| ..  ..|
gtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallell
0051429 (Phosphotyrosine protein) phosphatases II 6-141 2.5e-20 68.7 In-house 17-223 (272) alignment 
Range on Protein: 6-141
Range on HMM: 17-223/272.0
NKIIPG-LYLGNIR---DSKDAEQLQEHNITHILSIHDNA-------NPLREDIMYKCIHAADSPDQDLMPFF---------------------------
....|| ||...     . .| ..|.|..|..|... .          .. ..| | ...  |. ...   ..                           
rvvkpgrlyrsggplpltaadfwrlkelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseellldyilrellltlllsa

---------------------QECIEFIHSCRVkEMNCLVHCIAGISRSTTICAAYIMTiTELS--------------WRQTLQAIRANRSIANPNYGFK
                     ....|... ..  . ..|||| ||..|. |..|....    .|              ...... .|| |  |...... 
gearevmhlhytdwpdhgvpqeallellellld.ggpvlvHCsaGkdRTGtvvalllll.lgvsletivddYlltnlyleeaveelraqrpgavqteeqy

RQLQDFYNK
..|.... .
lflyealle
subfamily_STYXL1_pd Subfamily STYXL1 8-141 1.2e-18 60.8 In-house 14-152 (157) alignment 
Range on Protein: 8-141
Range on HMM: 14-152/157.0
IIPG-LYLGNIRDSKDAEQLQEHNITHILSIHDNANPLREDIMY--KC--IHAADSPDQDLMPFFQECIEFIHSCRVKEMNCLVHCIAGISRSTTICAAY
..|| ||||| ..... .  ..  .   . .  .|..| . .    |   |.  |... ||.....| ..||.. . ..   ||    |||||... .||
vlPgklylGnykqaqnpaikkdlkvkahvnvsmdadkliagvadvakllhiavedeneadllerlkeavqfiekhkkegevvlvfsnkGisrsaaviiay

IMTITELSWRQTLQAIRANRSIANPNYGFKRQLQDFYNK
.|   ... ..... ..  ..  .|| .|  ||... ..
lmyskkitlkkaykylkkCkenvkPnrafveqlseWekq
0038934 (Phosphotyrosine protein) phosphatases II 5-142 5.7e-18 60.7 In-house 31-176 (194) alignment 
Range on Protein: 5-142
Range on HMM: 31-176/194.0
MNKIIPGLYLGNIRDSKDAEQLQEHNITHILSIH------DNANPLREDIMYKCIHAAD---SPDQDLMPFFQECIEFIHsCRVKEMNCLVHCIAGISRS
..| |..||  ...|  .  .|. ..........      |     . .| |  .   |   .|.....  | . .....  . ..  ..||| ||..|.
ldkyieelyrfspedlvrylkllnvklglvidltnteryYdpeefekagieylklpfpddgtvPsleillrfldlvdefl.nedpggvvaVHCkaGlgRt

TTICAAYIMTITELSWRQTLQAIRANRSIANPNYGFKRQLQDFYNKH
 |..|||..    .| .. .. .|  |  | ||... ..|. .|.  
GtlvaaYLiyrlgmsaeeAialfrekRpgaipnqdyleallkrykel
subfamily_Sponge-DSP-Subfam1_pd Subfamily Sponge-DSP-Subfam1 12-138 1.4e-17 57.2 In-house 6-137 (145) alignment 
Range on Protein: 12-138
Range on HMM: 6-137/145.0
LYLGNIRDSKDAEQLQEHNITHILSIHD-----NANPLREDIMYKCIHAADSPDQDLMPFFQECIEFIHSCRVKEMNCLVHCIAGISRSTTICAAYIMTI
|| | .  ..|   |||  |. |. .         .   |.|    | | |    ||   |.|  .||   . .    .|||.||.||| |.  |..|  
lyvgsalhandvptlqelgisrivnmaagslvasqelksesieillitaedlesydlsqhfdevtdfidkgkeegagvfvhcmagvsrsvtvsvaflmky

TELSWRQTLQAIRANRSIANPNYGFKRQLQDF
 ...  .. . .|.||  | ||  | ..| ..
cnmtlseaarqvrsnrllaypnvtflknllnl
0043336 (Phosphotyrosine protein) phosphatases II 25-139 7.4e-17 57.2 In-house 107-273 (278) alignment 
Range on Protein: 25-139
Range on HMM: 107-273/278.0
QLQEHNITHILSIHDNA----------------------------------------------NPLREDI--MYKCIHAADSPDqDLMPFFQECIEFIHS
 ..|...|.|... .                                                .. |.     |...   . |. .| .... . .... 
mvwelgvttivmLtelvelgrvkcaqYwpggsltygdftvtllkeehlddytvrtlevtnlgdgesrtvthyhylgwpdhgvpe.slsllldflkavrea

CRVKEMNCLVHCIAGISRSTTICAAYIM-----TITELSWRQTLQAIRANRSIANPNYGFKRQLQDFY
.. ..   |||| ||..|. |..|.|..     .. ...  .... .|  |  | ..  . |.| .. 
ledsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflyeal
0050432 (Phosphotyrosine protein) phosphatases II 27-129 5.1e-16 54.3 In-house 178-285 (308) alignment 
Range on Protein: 27-129
Range on HMM: 178-285/308.0
QEHNITHILSIHDNANPlrEDIMYKCIHAADSPDQDLMPFFQECIEFIHSCRVK--EMNCLVHCIAGISRSTTICAAYIM-----TITELSWRQTLQAIR
... ..  | . .. ..  | .... .|  . ||..  | ......|.. .| .  . ...||| ||..|. |..|....     .  .... .... .|
lddytvrtleltnlgdg..esrtvthfhytnWpdhgvPpspeilldflelvrkslpggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklR

ANRSIANPNY
  |  . ...
eqRpgmvqtp
0047943 (Phosphotyrosine protein) phosphatases II 29-138 5.8e-16 54.2 In-house 149-267 (273) alignment 
Range on Protein: 29-138
Range on HMM: 149-267/273.0
HNITHILSIHDNANPlrEDIMYKCIHAADSPDQDLMPFFQECIEFIHSCRV------KEMNCLVHCIAGISRSTTICAAYIM-----TITELSWRQTLQA
. ... | . .. ..  |  .....|  . ||..  | .....|||. .|       ..   .||| ||..|. |..|....     .  ...  .... 
dytvrtleltnlgtg..esrtvthfhytgwpdhgvppslesllefielvrkalealpsngpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkl

IRANRSIANPNYGFKRQLQDF
.|  |  . ... . |.| ..
lrsqRpgmvqtpeqyrflyea
0051299 (Phosphotyrosine protein) phosphatases II 28-129 1.4e-14 49.7 In-house 114-272 (288) alignment 
Range on Protein: 28-129
Range on HMM: 114-272/288.0
EHNITHIL----------------------------------------------SIHDN--ANPLREDIMYKCIHAADSPDQDLMPFFQECIEFIHSCRV
|.|...|                                                . ..   ..  | .... .|  . ||..  . ......|.. .| 
eqnvrvIvmltklvelgrekcaqYwplggsltygditvtllseevlddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpdspellldflrlvrk

K----EMNCLVHCIAGISRSTTICAAYIM-----TITELSWRQTLQAIRANRSIANPNY
.    .  ..||| ||..|. |..|....     .  .... .... .|  |  . .. 
alasgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtp
subfamily_PTPMT1_pd Subfamily PTPMT1 65-144 2.4e-14 48.1 In-house 91-170 (171) alignment 
Range on Protein: 65-144
Range on HMM: 91-170/171.0
PFFQECIEFIHSCRVKEMNCLVHCIAGISRSTTICAAYIMTITELSWRQTLQAIRANRSIANPNYGFKRQLQDFYNKHLT
   .. .|||.. . |     ||| || .||.|. |.|.|. ..||  . |.|... |.| . .    ..|| ...|.|.
eklekgvefiekvaskgkrvYvHCkaGrgRsatlvacylmkkeklspeeAlkalkkkRkiirlakkqwkalqeyeeklls
0046845 (Phosphotyrosine protein) phosphatases II 29-127 1.5e-12 42.9 In-house 147-258 (284) alignment 
Range on Protein: 29-127
Range on HMM: 147-258/284.0
HNITHILSIHDNaNPLREDIMYKCIHAADSPDQDLMPFFQECIEFIHSCRVK------EMNCLVHCIAGISRSTTICAAYIMTIT--------ELSWRQT
. ... |.. .. ..  | .. . .|  . ||..  | ..  .||.. .|        .   .||| ||..|. |..|....           ...  ..
dytvrtleltnl.gytgesrtvthfhytswpdhgvppspedlleflrlvrellenlpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvlea

LQAIRANRSIANP
.. .|  |  .  
vkrlreqRpgmvq
subfamily_MSG5_pd Subfamily MSG5 69-138 1.6e-12 40.8 In-house 87-156 (165) alignment 
Range on Protein: 69-138
Range on HMM: 87-156/165.0
ECIEFIHSCRVKEMNCLVHCIAGISRSTTICAAYIMTITELSWRQTLQAIRANRSIANPNYGFKRQLQDF
.  . ||. . |.   ||||  |.|||...  ||||   .|| |.. . ...     .|. |.  || ..
rltriihaatskrkkilvhcqcglsrsaslivayimkyynlslrdaydklksvaddispsiglifqlmew
PTPc_DSPc_SM00012 54-122 7.7e-10 34.3 In-house 6-86 (105) alignment 
Range on Protein: 54-122
Range on HMM: 6-86/105.0
HAADSPDQDLMPFFQECIEFIHSCRVKEM------NCLVHCIAGISRSTTICAAYIMTITE------LSWRQTLQAIRANR
|  . ||. .    .. .|...... ..       ...||| ||..|. |..|..|.          ... |.....|  |
hytgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqR
0048567 (Phosphotyrosine protein) phosphatases II 47-127 2.3e-09 31.8 In-house 38-125 (157) alignment 
Range on Protein: 47-127
Range on HMM: 38-125/157.0
DIMYKCIHAADSP--DQDLMPFFQECIEFIHSCRVKEMNCLVHCIAGI---SRSTTICAAYIMTITELSWRQTLQAIRANR--SIANP
...|   .. . |     |. |..   .|..... ..    ||| ||    .|. |....|.. .  .. ..... .|  |  |.  .
glvyedfffdfGPlnlailyrFilklnkflkilelagkaiavhckaglkkrgrtatLigcYlilhlgftpeeaiaplrivrpgsvpfr
Y_phosphatase Protein-tyrosine phosphatase 24-122 7.5e-09 30.7 Pfam-A 110-216 (235) alignment 
Range on Protein: 24-122
Range on HMM: 110-216/235.0
EQLQEHNITHILSIHDNANPLREDIMyKCIHAADSPDQDLMPFFQECIEFIHSCRVKE----MNCLVHCIAGISRSTTICAAYIMTI--TE---LSWRQT
.. ... ... |........ .. .. | .|  . ||...    .. ...|.... ..     ...|||.||..|. |..|. |.    ..   ..  |.
kedekeytlrklelkkkkeesekrev.kqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleqleaeeevdvlqi

LQAIRANR
.. .|..|
vkelRkqR
Y_phosphatase Protein-tyrosine phosphatase 24-122 7.5e-09 30.7 In-house 110-216 (235) alignment 
Range on Protein: 24-122
Range on HMM: 110-216/235.0
EQLQEHNITHILSIHDNANPLREDIMyKCIHAADSPDQDLMPFFQECIEFIHSCRVKE----MNCLVHCIAGISRSTTICAAYIMTI--TE---LSWRQT
.. ... ... |........ .. .. | .|  . ||...    .. ...|.... ..     ...|||.||..|. |..|. |.    ..   ..  |.
kedekeytlrklelkkkkeesekrev.kqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleqleaeeevdvlqi

LQAIRANR
.. .|..|
vkelRkqR
DSPc_SM00195 28-105 8.1e-08 27.3 In-house 140-219 (263) alignment 
Range on Protein: 28-105
Range on HMM: 140-219/263.0
EHNITHILSIHDNANplREDIMYKCIHAADSPDQDLMPFFQECIEFIHSCRVKEM----NCLVHCIAGISRSTTICAAYIMT
.. |.. |..  ...  .|.   . ..  . ||...    ....|...... ..      ..||| ||..|. |.... |. 
deiilrtleltkegk..eetrkvtqyqyknWpdhgvpdstksvlellravkkskstssgpivVhCsaGvgRtgtfvtidiil
PTPc_SM00194 28-105 8.1e-08 27.3 In-house 140-219 (263) alignment 
Range on Protein: 28-105
Range on HMM: 140-219/263.0
EHNITHILSIHDNANplREDIMYKCIHAADSPDQDLMPFFQECIEFIHSCRVKEM----NCLVHCIAGISRSTTICAAYIMT
.. |.. |..  ...  .|.   . ..  . ||...    ....|...... ..      ..||| ||..|. |.... |. 
deiilrtleltkegk..eetrkvtqyqyknWpdhgvpdstksvlellravkkskstssgpivVhCsaGvgRtgtfvtidiil
subfamily_CDKN3_pd Subfamily CDKN3 67-123 5.8e-07 23.3 In-house 115-175 (202) alignment 
Range on Protein: 67-123
Range on HMM: 115-175/202.0
FQECI---EFIHSCRVKEMNCLVHCIAGISRSTTICAAYIMTIT-ELSWRQTLQAIRANRS
  .|.   | .. .  .  . ||||  |. ||. . |  .. .   ........ .|  . 
iasclkileelrinlkayrktlvhcygglgrsslviaclllylddtiepkdaidklrdlkg
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 10-104 6.3e-07 23.3 In-house 154-245 (305) alignment 
Range on Protein: 10-104
Range on HMM: 154-245/305.0
PGLYLGNIRDSKDAEQLQEHNITHILSIHDNAnplrEDIMYKCIHAADSPDQDLMPFFQECIEFIHSCRVKEMNCLVHCIAGISRSTTICAA-YIM
 |. . |.  ||  |.  | .|| .   .       . .  . .. .. ||. . |     .|.. . |  ..  .||| ||| |. || |  ||.
sgivvenvsgskpmerdaeiqitllnltysgd....qkmsvrhlqwtewpdrgvppckltslellsairgskvpivvhcsagigrtgtivaieyil
subfamily_DSP23_pd Subfamily DSP23 24-140 9.1e-07 23.6 In-house 25-146 (148) alignment 
Range on Protein: 24-140
Range on HMM: 25-146/148.0
EQLQEHNITHILSIHDNANPLREDIMYKCIHAADSPDQDlMPFFQECIEF---IHSCRVKEMNCLVHCIAGISRSTTICAAYIMTITELSWRQTLQAIRA
. | .  . ...|. ....|  | .    ..    .|    |  ..  ||   ..    |.    |||. |  |. |. | |..   .|.  ...  .| 
rylldlgvrylvslteegrphveatpnltlvrlriddyh.ppaleqvvefvrvveeaeekneavsvhcllgrgrtgtmlacylvkerklaaaeaiaevrr

NRSIANPNYGFKRQLQD---FYN
 |  .   .  .. ..|   |.|
lrpgsvetveqeklvrdyetfin
subfamily_PTPDC1_pd Subfamily PTPDC1 76-125 1.8e-06 22.5 In-house 109-158 (182) alignment 
Range on Protein: 76-125
Range on HMM: 109-158/182.0
SCRVKEMNCLVHCIAGISRSTTICAAYIMTITELSWRQTLQAIRANRSIA
.  ..| .  ||| ||  |   . |.|..  ..|.  .... .|..|. .
afalqegkvavhChaGlGrtGvliacylvyakrltaekaiklvrskrpks
subfamily_Laforin_pd Subfamily Laforin 65-126 2e-06 20.8 In-house 94-155 (183) alignment 
Range on Protein: 65-126
Range on HMM: 94-155/183.0
PFFQECIEFIHSCRVKEMNCLVHCIAGISRSTTICAAYIMTITELSWRQTLQAIRANRSIAN
  . ... ..|.   |     ||| ||. |||.|   ... . . | ..    . |.| .. 
enlpqavyllhallekghivyvhcnagvgrstaivcgflqyvlgwslakvqyfllakrpvvy
subfamily_RNGTT_pd Subfamily RNGTT 45-140 4.7e-06 20.4 In-house 75-172 (189) alignment 
Range on Protein: 45-140
Range on HMM: 75-172/189.0
REDIMYK---CIHAADSPDQDLMPFFQECIEFIHScRVKEMNCLVHCIAGISRSTTICAAYIMTITELSWRQTLQAIRANRSIANPNYGFKRQLQDFYN
.|.| |.   |    ..|... .  |.. .|  .. .  |    |||  |  |.  . ..|..  .. | .. ... . .|     .  . ..| . |.
kegikyvklqcagkgeaPeaeqvkefiklveeffk.knpeevigvhCthGfnRtGFlivsyLvekedwsveaavalFakaRppGiykedylkellrrYa
subfamily_CDC14_pd Subfamily CDC14 72-122 9.4e-06 19.7 In-house 254-304 (328) alignment 
Range on Protein: 72-122
Range on HMM: 254-304/328.0
EFIHSCRVKEMNCLVHCIAGISRSTTICAAYIMTITELSWRQTLQAIRANR
.|.. .   | .  ||| ||. |  |. |.|.|   ...  ...  .|  |
kfleiaekaeGaiavhCkaGLGrtGtLiacylmkhyrftaaeaiawlricr