Gene DSP3 in Nematostella vectensis

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family DSP
Subfamily DSP3
Protein sequence
ID Type Fasta BLAST phosphatome Note
NvecP011_AA protein Get Run
NvecP011_AA_30-185 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_DSP3_pd Subfamily DSP3 25-186 6.9e-67 218.1 In-house 3-159 (162) alignment 
Range on Protein: 25-186
Range on HMM: 3-159/162.0
KYRFPSKAYDEVFDGIYVGGAVTAMEEDQLVALGVTHVLNAAQGtkRLSHVNTDASFYK-SGIIFHGIPATDVFMFKLNKYFDEAADFIASAVGTkncpK
..|..||..|||....|||.. .|.....| .||.|||||||.|  |.|.|.|.|.||| ..| ..|....||..|.|.|||..||.||..|. .    |
lerllskevdevypklyvgdeavakdkskLkklGithvlnaaeg..rfskvdtgaefykdleikylGlevdDvpefdlskyFetaakfidealsq....k

NGRVYVHCKEGISRSATLVLAYLIKHQQMGLTNALRTVRSKRMVYPNMGFMEQLIDYSHKLNR
.|.|.|||..|.|||||||||||. ...| |..|.||||.||...||.||..||......|.|
egkvlvhcvvGvsRsatlvlayLmirrkmtlveairtvrkkReilPneGFlkqLaeldeelkr
0044763 (Phosphotyrosine protein) phosphatases II 24-184 5.2e-38 125.8 In-house 14-170 (178) alignment 
Range on Protein: 24-184
Range on HMM: 14-170/178.0
GKYRFPSKAYDEVFDGIYVGGAVTAMEEDQLVALGVTHVLNAAQGTKRLSHVNTDASFYKSGIIFHGIPATDVFMFKLNKYFDEAADFIASAVGtkncPK
|  |..   ..|...|.|.|.. .|.  ..| .||.||..| .. . .  . .    . . || .. ||  |   . | ..|.|. .|| .|.     .|
glersdyinaseilpglylgslppaddlellkelgithivnlteelelgflkcdpywpeeagiqylhipipDhgvpdllehflefvefieeald....ek

NGRVYVHCKEGISRSATLVLAYLIKHQQMGLTNALRTVRSKRMVYPNMGFMEQLIDYSHKL
.|.|.|||. |..||.|||.|||.|.... | .|.. ||..|...||.|...||...  .|
ggpvlVHCsaGvgRsgtlvaaylmkklglsleeaielvrerRpivpnpgqlrqLyefelrl
PTPc_motif_SM00404 35-182 1.3e-32 107.6 In-house 4-139 (140) alignment 
Range on Protein: 35-182
Range on HMM: 4-139/140.0
EVFDGIYVGGAVTAMEEDQLVALGVTHVLNAAQGTKRLshvntdasfY-KSGIIFHGIPATDVFMFKLNKYFDEAADFIASAvgtknCPKNGRVYVHCKE
.. ...|.|.. .|.....| .||.|||.|...  .           . .||. .  ||  |    || ||.|...||| .|       |.|.|.|||. 
rilphlylgskskaqnpallkklgithvinvteevslt.........kensgfqilqiplddnekdklskyldkvldfiena.....ekkggkvlVHCqa

GISRSATLVLAYLIKHQQMGLTNALRTVRSKRM-VYPNMGFMEQLIDYSH
|.||||||..|||.. .|. | .|.. |...|  . ||..|..|||.|  
GvSRSatliiaYlmryrqlslaeayefvkerRpiispnlnfvrqLieyek
subfamily_DSP1_pd Subfamily DSP1 32-185 2e-32 106.6 In-house 14-157 (163) alignment 
Range on Protein: 32-185
Range on HMM: 14-157/163.0
AYD---EVFDGIYVGGAVTAMEEDQLVALGVTHVLNAAQGtkrLSHVNTDasfyksGIIFHGIPATDVFMFKLNKYFDEAADFIASAvgtKNcpKNGRVY
.||   .. | .|.|.. .| . ..| .||.|..||...    |. |  |         .. ..  |  .  . ..|.|. .|| ..   |.  |||.|.
lydPvekildfLylGsetvasnleiLkslgitailnvske...ldnvfed......lfeYkklkleDspkadislvfeeviefidev...kk..knGkvl

VHCKEGISRSATLVLAYLIKHQQMGLTNALRTVRSKRMV-YPNMGFMEQLIDYSHKLN
.||. |||||.||.||||.|.... |..|   |...| .  ||.||. ||..| .|| 
ihCqaGisRsstlclaylmktkrvsleeafdfvkqrRsiisPnagFvlqLlnyekkll
0048076 (Phosphotyrosine protein) phosphatases II 34-184 1.3e-31 104.6 In-house 5-142 (145) alignment 
Range on Protein: 34-184
Range on HMM: 5-142/145.0
DEVFDGIYVGGAVTAMEEDQLVALGVTHVLNAaqgtkrlshVNTDASFYKSGIIFHGIPATDVFMFKLNKYFDEAADFIASAVGTkncpkNGRVYVHCKE
.|...|.|.|.  ||.. ..|  ||.|.|||           ..   ... || .. .|  |   . | ....|. .|| .|.       .|.|.|||. 
seilpglylgslptaldlellkdlgittvlnl.........tselellerlgiqylylpwpDhgvpdllellleflefieealke.....ggpvlVHCsa

GISRSATLVLAYLIKHQQMGLTNALRTVRSKRM-VYPNMGFMEQLIDYSHKL
|..|..|||.|||...... | .||. |||.|. . ||.|....|... ..|
GvgRtgtlvaaylmlllgvsleealelvrsqrpgavpnpgqlrflyefelel
PTEN_1 18-185 1.8e-31 104.5 In-house 25-192 (196) alignment 
Range on Protein: 18-185
Range on HMM: 25-192/196.0
IINETIGKYRFPSKA-YDEVFDGIYVGGAVTA-MEEDQLVALGVTHVLNAAQGTKRlSHVNTDAS-FYKSGIIFHGIPATDVFMFKLNKYFDEAADFIAS
|  . |.. ..||.  ..|...| |.| .  . .  |.| . |.|.|.| . . .  | .. | . |.|||.... .| .|     |.. ||....|| .
itsriiamgkapsrpllqeideglyrgslkdvaadldnlkedgitlvvnlseeeel.sgrsydleeffksgveylhfpieDhgapslselfdicksfiew

AVGTKNcpkNGRVYVHCKEGISRSATLVLAYLIKHQQMGLTNALRTVRSKR-MVYPNMGFMEQLIDYSHKLN
.   .|   .. |.|||| |..||.|.| |||......   .||. ||.||  . ||....|.|. | ..|.
llsdpn...gnvVlVHCkaGlgRsGtvvaayLmykgkltadeAlelvrekRppgapnspsqerlleyfaell
subfamily_DSP14_pd Subfamily DSP14 33-185 2.7e-31 102.6 In-house 7-145 (157) alignment 
Range on Protein: 33-185
Range on HMM: 7-145/157.0
YDEVFDGIYVGgAVTAMEEDQLVALGVTHVLNAAQgtkrlSHVNT-----DasfyksgiiFHGIPATDVFMFKLNKYFDEAADFIASAVGtkncpKNGRV
  .. . .... .|.|.....| . ..|...|...       .||     .            .|..|    || |.|||.|| | ..       |.|..
lsqitpsLfls.gvaalskellkkkkitliinvtv.....elpntklkdie.........rvkvpveDnpeaklakhfdevadkieevkk.....kggkt

YVHCKEGISRSATLVLAYLIKHQQMGLTNALRTVRSKR-MVYPNMGFMEQLIDYSHKLN
 |||. |.||||.|.||||.|.... | .| ..|.|.| .. ||.|| .||||| .||.
lvhCvaGvSRSAslclaylmkyeklsLreayklvksaRpiirPNvGFwkqlidyEkklk
0048179 (Phosphotyrosine protein) phosphatases II 33-183 2.9e-31 103.5 In-house 4-143 (144) alignment 
Range on Protein: 33-183
Range on HMM: 4-143/144.0
YDEVFDGIYVGGAVTAMEEDQLVALGVTHVLNAAQGTKRLSHVNTdasfyksGIIFHGIPATDVFMFKLNKYFDEAADFIASAVGtkncpKNGRVYVHCK
..|...|.|.|.  ||.. ..| .||.|.|.| . .    .  ..       || .. .|  |   . | ....|. .|| .|.      ..|.|.|||.
pseilpglylgslptaldlellkklgittvinlteeyepeflere.......giqylhlpwpDhgvpdllellleflefieeale.....eggpvlVHCs

EGISRSATLVLAYLIKHQQMGLTNALRTVRSKRM-VYPNMGFMEQLIDYSHK
 |..|..|||.|||.|.... | .||. |||.|. ..||.|....|..|...
aGvgRtgtlvaaylmkklglsleealalvrsrrpgavpnpgqlrfLleyekl
DSPc Dual specificity phosphatase, catalytic domain 40-182 5.1e-31 102.3 Pfam-A 1-132 (133) alignment 
Range on Protein: 40-182
Range on HMM: 1-132/133.0
IYVGGAVTAMeEDQLVALGVTHVLNAAQGTKRLshvntdASFYKSGIIFHGIPATDVFMFKLNKYFDEAADFIASAvgtknCPKNGRVYVHCKEGISRSA
.|.|.. ||. ...| .||.|.|.|... ..         .. || | . .||  |    |. |...|| .||..|       |...|.|||. ||||||
lylgskstas.lalleklgitlvinvtkevpnn......naikkseieylripvedetetkiskeleeavefieka.....eqkgkkvlVHCqaGisRSa

TLVLAYLIKHQQMGLTNALRTVRSKRM-VYPNMGFMEQLIDYSH
||..|||.| ... |..|.. |...|  . ||.||. ||..|  
tliiaYlmktknlslneAyefvkerrskispnagflrqLleyer
DSPc Dual specificity phosphatase, catalytic domain 40-182 5.1e-31 102.3 In-house 1-132 (133) alignment 
Range on Protein: 40-182
Range on HMM: 1-132/133.0
IYVGGAVTAMeEDQLVALGVTHVLNAAQGTKRLshvntdASFYKSGIIFHGIPATDVFMFKLNKYFDEAADFIASAvgtknCPKNGRVYVHCKEGISRSA
.|.|.. ||. ...| .||.|.|.|... ..         .. || | . .||  |    |. |...|| .||..|       |...|.|||. ||||||
lylgskstas.lalleklgitlvinvtkevpnn......naikkseieylripvedetetkiskeleeavefieka.....eqkgkkvlVHCqaGisRSa

TLVLAYLIKHQQMGLTNALRTVRSKRM-VYPNMGFMEQLIDYSH
||..|||.| ... |..|.. |...|  . ||.||. ||..|  
tliiaYlmktknlslneAyefvkerrskispnagflrqLleyer
0041856 (Phosphotyrosine protein) phosphatases II 32-185 6.8e-31 102.7 In-house 18-173 (182) alignment 
Range on Protein: 32-185
Range on HMM: 18-173/182.0
AYDEVFDGIYVGGAVT--------------AMEEDQLVALGVTHVLNAAqgtkrlSHVNTDASFYKSGIIFHGIPATDVFMFKlnkyFDEAADFIASAVG
 .|.. ...|.|.  .              |.  ..|  ||.|...|..      ..      ... || .. .|  |   .     .||. |||  .  
dldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt......eelywpellerlgiqylylpwpDhgvpd....ldelldfieevle

tkncpKNGRVYVHCKEGISRSATLVLAYLIKHQQMGLTNALRTVRSKRM---VYPNMGFMEQLIDYSHKLN
     ..|.|.|||. |..|..|||.|||.|.....|..|...|||.|.   ..||..|..||. . ..|.
.....eggpvlVHCsaGvgRtgtlvaaylmkklgvsleeavklvrsrRpgmvitpnqyfflqlallellll
subfamily_DSP10_pd Subfamily DSP10 34-186 6.8e-31 101.3 In-house 15-155 (159) alignment 
Range on Protein: 34-186
Range on HMM: 15-155/159.0
DEVFDGIYVGGAVTAMEEDQLVALGVTHVLNAAQgtkrlshvNTDASFYKSGIIFHGIPATDVFMFKLNKYFDEAADFIASAvgtKNcpKNGRVYVHCKE
 .|.  ...| .. | ..| |  |..|.||| ..        ..   |..... .. ||..|    .|..||.|| .||  |   ..  |. || |||. 
sqvlpfLflGsekdaadldaldrlnitavlnvtt........svPnefeeealkYkripvsDtskqnlkqyfeealefieea...rk..kgsrvLvhCqa

GISRSATLVLAYLIKHQQMGLTNALRTVRSKRM-VYPNMGFMEQLIDYSHKLNR
|||||||.|.|||.||... |..| . |..||  . ||..|| ||... ..||.
GisrsatvviaYlmkhlnlslndaykfvkekrpiisPnLnfmGqLlefekelnk
0049772 (Phosphotyrosine protein) phosphatases II 33-184 7.5e-31 103.4 In-house 155-273 (314) alignment 
Range on Protein: 33-184
Range on HMM: 155-273/314.0
YdevfdgiyvgGAVTAMEEDQLValgvthvlnaaqgtkrlSHVNTDASFYKSGIIFHGIPATDvFMFKLNKYFDEAADFIASAvgtkncPKNGRVYVHCK
.          .  ||.. ..|                  . .. .  | . || .. || .| . . | ..|||. .|| .|      .|.|.|.||||
g..........neptaadlellk.................eelydpelferlgikylripvpD.gsaplledfdeflefieea......dkggpvlvHCk

EGISRSAT-LVLAYLIKHQQMGLTNALRTVRSKRMVYPNMGFMEQLIDYSHKL
 |..|..| .|.|||.|.... |  ||. ||.||...||.||.|||..|  .|
aGkgRtgtfvvaaylmkllgvsleealedvrlkRpinpnpgfieqleqyefil
subfamily_DSP12_pd Subfamily DSP12 34-181 2.4e-30 100.0 In-house 3-140 (155) alignment 
Range on Protein: 34-181
Range on HMM: 3-140/155.0
DEVFDGIYVGGAVTAMEEDQLVALGVTHVLNAAQGTKrLSHVNTDASFYKSGIIFHGIPATDVFmfklnKYFDEAADFIASAVgtkncPKNGRVYVHCKE
... .|.|.||. ...||..|  |..||||  .. .   .| ..    ..  |     | .|..     ...||| ||| .|.      ..| |.|||. 
srilpglylggleavqeeellkelkithvlsvikeel.pehklkkgkvstkfiqilDepeediL.....shldeavdFieeal.....eeegavlvHCqa

GISRSATLVLAYLIKHQQMGLTNALRTVRSK-RMVYPNMGFMEQLIDYS
|.|||.|.|.|||.|.... |..||..|..| . ..|| ||.|||  . 
gvSRSvtiviAYlmkkeklslekAlklvkekkpeiepNegFleQLklfe
subfamily_DSP19_pd Subfamily DSP19 35-184 2.5e-30 99.8 In-house 14-150 (152) alignment 
Range on Protein: 35-184
Range on HMM: 14-150/152.0
EVFDGIYVGGAVTAMEEDQLVALGVTHVLNAAQGTKRlshvntdasFYKSGIIFHGIPATDVFMFKLNKYFDEAADFIASAVGTKncpknGRVYVHCKEG
|| . .|.|   .|.....|   ..||.|| | |...         .. . . .  |.  |.   .| .|..|| ||| .|  ..     |.|.|||. |
eveprlylgsqdvaadkeilkekkitHilnvatgvpn.........vfpkdftylsieilDlpetdllsylkealdFieearskd.....gavlvHCnAG

ISRSATLVLAYLIKHQQMGLTNALRTVRSKR-MVYPNMGFMEQLIDYSHKL
.||||..|.|||.|.... |..||..||..|  . || ||..|| .| ..|
vSRsasvviaylmkkeelsleealelvrearpcikPneGFikqLkeyeael
subfamily_DSP8_pd Subfamily DSP8 33-185 1.7e-29 96.4 In-house 15-155 (159) alignment 
Range on Protein: 33-185
Range on HMM: 15-155/159.0
YDEVFDGIYVGGAVTAMEEDQLVALGVTHVLNAAQGTKRLSHVNTDasfyksgIiFHGIPATDVFMFKLNKYFDEAADFIASAVgtkncPKNGRVYVHCK
  .. . .|.|  . ...|. | .||...|||| .   .|. .. .         |. .|  | .  ||  .||.. .||  |.      .|||| ||. 
ptrilknlylGsqkdvlseellsklgisyvlnasnscpkleelkes.......k.flrvPvkDkydekllpwfdksvefidkak.....sengrvlvhvl

EGISRSATLVLAYLIKHQQMGLTNALRTVRSKR-MVYPNMGFMEQLIDYSHKLN
 |||||||...||..|. .|.| .| | |..|| .. ||. |..||..| ..|.
aGisrsatvaiayimktlemsldeayrfvkekrptispnlnflgqLleyekelk
0046846 (Phosphotyrosine protein) phosphatases II 30-185 1.1e-28 95.5 In-house 9-173 (176) alignment 
Range on Protein: 30-185
Range on HMM: 9-173/176.0
SKAYDEVFDGIYVGGAV----------TAMEEDQLVALGVTHVLNAAQGTKRLS--HVNTDASFYKSGIIFHGIPATDVFMFKLnKYFDEAADFIASAVG
   .|.. .....|..           .|   ..|  ||.|.|.|  . .   .    |    ..| || .. .|  |     | ....|. .|| .|. 
dldldyinanlilgsrpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgiqylhlpwpDhgvpdl.elllellefirealk

TKncpknGRVYVHCKEGISRSATLVLAYLIKH-QQMGLTNALRTVRSKR--MVYPNMGFMEQLIDYSHKLN
 .     |.|.|||. ||.|..|||.|||... ... . .||..||..|  .. ........| .. ..|.
eg.....gpvlVHCsaGigRtgtlvaayllelekglsveealalvreqRplgavqtpeQyrflyefellll
0043147 (Phosphotyrosine protein) phosphatases II 33-184 2.8e-28 94.2 In-house 19-160 (172) alignment 
Range on Protein: 33-184
Range on HMM: 19-160/172.0
YDEVFDGIYVGGAVTAMEEDQLVALGVTHVLNAAQGtkrlshVNTDASFYKSGIIFHGIPATDVFMFkLNKYFDEAADFIASAVgtkNCPKNGRVYVHCK
 |..... ....  .|.  ..|  ||.||..|. .       ...   ....|| .. .|  |   . | ....|. .|| ...   .  ..|.|.|||.
pdrfiatqgplrntladfwrmlkelgithivnltel......lydpellerlgiqylylpwpDhgvp.llellleflefidell...alspggpvlVHCs

EGISRSATLVLAYLIKhQQMGLTNALRTVRSKRM-VYPNMGFMEQLIDYSHKL
 |..|..|||.|||.. ... | .|...||.||. . .| ... .| .....|
aGvgRtgtlvaaylml.lglsleeavalvrekRpgavqnpsqyrflyyfekll
0036282 (Phosphotyrosine protein) phosphatases II 35-184 2.1e-27 91.4 In-house 14-169 (174) alignment 
Range on Protein: 35-184
Range on HMM: 14-169/174.0
EVFDGIYVGGAVTAmEEDQLVALGVTHVLNAAQGTKRLSHVN------TDASFYKSGIIFHGIPATDVFMFKLNKyFDEAADFIASAVGTkncPKNGRVY
.. .....|.. .|   ..|  ||.|.|..  .   . ..        .  .....|| .. .|  |  .. |.. ..|. .|. .|.     ...| |.
yitprliagqgpla.fwemlkelgittvvmlleekelglykcinywpelredlerlgiqylylpwpDhgvpdlsi.llefvkfveealse...dpggpvl

VHCKEGISRSATLVLAYLIKHQQM-GLTNALRTVRSKR----MVYPNMGFMEQLIDYSHKL
|||. |..|..|||.|||...... .| .||..||..|    ...........| ... .|
VHCsaGvgRtGtlvaaylmlrglleslvdaldlvrelRlqrpgmvqtpsQyrflyyfekll
subfamily_DSP6_pd Subfamily DSP6 35-185 3.6e-27 88.8 In-house 16-155 (158) alignment 
Range on Protein: 35-185
Range on HMM: 16-155/158.0
EVFDGIYVGGAVTAMEEDQLVALGVTHVLNAAQgtkrlshvNTDASFYKSG-IIFHGIPATDVFMFKLNKYFDEAADFIASAVGtkncpKNGRVYVHCKE
|. . .|.| | .| . . |  |.. .||| ..        | .  | .|| . .  ||..|... .| |.| || .||  |       |.  | |||  
eilpllylGsakdasnlevlkklkikyvlnvts........nlpnkfeesgelkylqipiedhlsqnlakffPeaiefidears.....kkskvlvhCla

GISRSATLVLAYLIKHQQMGLTNALRTVRSKR-MVYPNMGFMEQLIDYSHKLN
||||| |..||||.|.... | .|   |....  . ||. ||.||.|. ..|.
GisrsvtvtlaylmkklalslndaydlvkkrksnisPnfnfmgqlldferslr
subfamily_DSP15_pd Subfamily DSP15 34-182 4.1e-27 89.1 In-house 3-137 (151) alignment 
Range on Protein: 34-182
Range on HMM: 3-137/151.0
DEVFDGIYVGGAVTAMEEDQLVALGVTHVLNAAQgtkrlshvntDASFYKSGIIFHGIPATDVFMFKLNKYFDEAADFIASAvgtknCPKNGRVYVHCKE
..|  |.|.|.   . .|..|    .||.|.  .          .|  .   | .. |.|.|    ||.|.|.|. .|| ..       |.. |.|||  
skvlpglylgnfrdskdeelLkeknithilsvhd..........nakkllkdieYkciaasDtpsaklskffkesvefihkc.....RlkeenvlvhCla

GISRSATLVLAYLIKHQQMGLTNALRTVRSKRMV-YPNMGFMEQLIDYSH
|.|||.||| |||.   ...  .||.... .|.|  ||.|| .|| .|..
GvsRsvtlvvaYlmtvtelnwrdalevikaaRsvanPnfGfkrqlkeyek
subfamily_LRR-DSP_pd Subfamily LRR-DSP 32-185 1.3e-26 87.3 In-house 119-259 (263) alignment 
Range on Protein: 32-185
Range on HMM: 119-259/263.0
AYDEVFDGIYVGGAVTAMEEDQLVALGVTHVLNAAQGTKrlshvntdaSFYKSGIIFHGI-PATDVFMFKLNKYFDEAADFIASavGTkncpKNGRVYVH
  ||. |....||  .|...  |  |||||.| |    .          ..     .  |  . ||  ... ..|.|   || .  |     |.| | ||
vPdeiidklflGgldsannksilkdlgvthillavadfe.........PlfPklfkylsiddiedvdeadisqhfeetnafiee..Gr....kkGGvlvh

CKEGISRSATLVLAYLIKHQQMGLTNALRTVRSKR-MVYPNMGFMEQLIDYSHKLN
|. |.|||.|||..||.|.|.. . .||  | .||  ..||.||..||  | .|| 
craGvsrsstlvisylmkkqrlkfkealdlvikkrpriqPnpGfkdqlkkyekklf
0045098 (Phosphotyrosine protein) phosphatases II 31-185 2.2e-26 88.3 In-house 20-272 (278) alignment 
Range on Protein: 31-185
Range on HMM: 20-272/278.0
KAYDEVFDGIYVGGAV-----------------------------------------TAMEEDQLVALGVTHVLNAAQGTKR------------------
   .|.....|.|..                                          .|   ..|  ||.|....... . .                  
gipseitpalylgnldknRykdilpydhsrVkdYINAsyidgypkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrekcaqywpeggsltyg

---------------------LSHV----NTDASFYKSGIIFHGIPATDVFMFKLNKYFDEAADFIASAVGTK---------NCPKNGRVYVHCKEGISR
                     . ..    ... |..   . ....|  .|  . . |.|.|. .|| .|. .            ...|.|.|||. |..|
dftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsggpvlVHCsaGvgR

SATLVLAYLIKHQ---QMGLTNALRTVRSKRM--VYPNMGFMEQLIDYSHKLN
..|||.|||....   .. | .|....||.|.  . .|......|...  .| 
tGtlvaaylmlelleggvdlleavkelrsqRpglavqnleqyrflyefllell
0051082 (Phosphotyrosine protein) phosphatases II 34-180 3.1e-25 83.9 In-house 9-149 (151) alignment 
Range on Protein: 34-180
Range on HMM: 9-149/151.0
DEVFDGIYVGGAVTAMEEDQLVALGVTHVLNAAQGTKRLshvnTDASFYKS-GIIFHGIPATDVFMFKLNKYFDEAADFIASAVGtkncPKNGRVYVHCK
  | .|.|..|. .|   ..|  ||.....|  . . |     ........ || .. || .|   ..|  .||....|.  .      .||| |.|||.
syvtgglyrsggpladflellkelgiktivnlrseeerg....ycpeylpelgievlhipildwpdpglplsfdavleflellld....kkngpvlvHCs

EGISRSATLVLAYLIKhQQMGLTNALRTVRSKR--MVYPNMGFMEQLIDY
 |..|..|||..||.. ... |  ||. .|.||  .|.||..|. ||...
aGkgRTGtlvalylml.lgvsleealeeyrlkrpgvvqpnqqflfqlfal
subfamily_Slingshot_pd Subfamily Slingshot 35-184 4.1e-25 82.1 In-house 21-157 (169) alignment 
Range on Protein: 35-184
Range on HMM: 21-157/169.0
EVFDGIYVGGAVTAMEEDQLVALGVTHVLNAAQGTKrlshvntdaSFYKSGIIFHGIPATDVFMFKLNKYFDEAADFIASAvgtKNcpKNGRVYVHCKEG
..|| .|.|    | . ..|   ||...|| ..  .         .|..  . .. |   |    .| ||..|. .||  |   |.  |. .| |||| |
kifdhvylGsewnasnleelkengveyilnvtkeid.........nffpekfeylnirvydeeetdllkywnetykfieka...kk..kgskvlvhckmG

ISRSATLVLAYLIKHQQMGLTNALRTVRSKRM-VYPNMGFMEQLIDYSHKL
.||||. |.|| .|. .. | .||. |...|  . || ||..||  |.  |
vsrsastviayamkeyglsleealeyvkerrsvikPnkgflkqleeyeGil
subfamily_Sponge-DSP-Subfam1_pd Subfamily Sponge-DSP-Subfam1 40-184 5.2e-24 78.0 In-house 6-141 (145) alignment 
Range on Protein: 40-184
Range on HMM: 6-141/145.0
IYVGGAVTAMEEDQLVALGVTHVLNAAQGtkrlSHVNTdASFYKSGIIFHGIPATDVFMFKLNKYFDEAADFIAsavgtKNCPKNGRVYVHCKEGISRSA
.||| |..| .   |  ||.. ..| | |    | | .  . .   |    | | |.  . | ..||| .|||      |   .   |.|||  |.||| 
lyvgsalhandvptlqelgisrivnmaag....slvas.qelksesieillitaedlesydlsqhfdevtdfid.....kgkeegagvfvhcmagvsrsv

TLVLAYLIKHQQMGLTNALRTVRSKRM-VYPNMGFMEQLIDYSHKL
|. .|.|.|. .| |..| | |||.|.  |||. |. .|..  ..|
tvsvaflmkycnmtlseaarqvrsnrllaypnvtflknllnlekql
subfamily_Choan-DSP_MKP-1_pd Subfamily Choan-DSP_MKP-1 27-183 5.9e-24 78.3 In-house 5-146 (148) alignment 
Range on Protein: 27-183
Range on HMM: 5-146/148.0
RFPSKAYDEVfdgIYVGGAVTAMEEDQLVALGVTHVLNAAQGTKRLSHVNtdasfyksGIIFHGIPATDVFMFKLNKYFDEAADFIASAVGtkncpKNGR
.|||. .|     ...|    |.. ..| |||||.. ||..  .    .         || .  ..  |   . |...|.....|.  |..     . .|
tfpseikdaf...LFlGskksaadlealkalgvtrivnatkerdnaldqr........gieYlhvaldDkpkedlsaiFediiafvrkakd.....eGrr

VYVHCKEGISRSATLVLAYLIKHQQMGLTNALRTVRSKR-MVYPNMGFMEQLIDYSHK
| ||.. |.|||. |.|..||..... | .||  |.||| .| ||.||..|| .. ..
vLvhlqmGvsrssalallwlidfkrvslkealalvkskrryvdpnlgfLkqLaeleqa
0049260 (Phosphotyrosine protein) phosphatases II 39-184 7.1e-24 79.6 In-house 14-149 (152) alignment 
Range on Protein: 39-184
Range on HMM: 14-149/152.0
GIYVGGAVTAMEEDQLVALGVTHVLNAAQGTKrlshvnTDASFYKSGIIFHGIPATDVFMFKLNKYFDEAADFIASAvgtkNCPKNGRVYVHCKEGISRS
....|.  .|   ..|  ||.|....  . .        .  . . .| .. .|  |    .|  ..... .||  .    .  |.|.|.|||. |..|.
tqgpgpntladfwrmlkelgittivmltelle......lgklkceqyiqylhlpwpDhgvpdlsqlllflllfiekl....aldkggpvlVHCsaGvgRt

ATLVLAYLIKhQQMGLTNALRTVRSKRM-VYPNMGFMEQLIDYSHKL
.|||.|||.. ... | .|.. ||.||. ..|| |....| ... .|
gtlvaaylml.lgvsleeavalvrekRpgavpnpgqlrflyefekll
0037934 (Phosphotyrosine protein) phosphatases II 32-182 9.1e-24 79.8 In-house 38-239 (243) alignment 
Range on Protein: 32-182
Range on HMM: 38-239/243.0
AYDEVFDGIYVGGA--------VTAMEEDQLVALGVTHVLNAAQGT-----------------------------------KRLSHVNTD-ASFYKSGII
 . .|.........        ..|   . |  ||.|....  . .                                     |. .|.|   ... .| 
nliyvtprliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywpgevtygdftvtllseehlddytvrtlllenldlddltrlvih

FHGIPATD----VFMFKLNKYFDEAADFIASAVGTKNCPKNGRVYVHCKEGISRSATLVLAYLIKHQ-QMGLTNALRTVRSKRM--VYPNMGFMEQLIDY
.| .|  |      .  | ...||. .|| ...   . ...|.|.|||. |..|..||..|||.... ...| .|....|..|.  . .. .....|...
yhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRtGtliaaylmllllgvdleeavkllreqRpgkavqtpsqyrflyea

SH
 .
ll
0040439 (Phosphotyrosine protein) phosphatases II 51-183 5.3e-22 74.1 In-house 71-244 (249) alignment 
Range on Protein: 51-183
Range on HMM: 71-244/249.0
EDQLVALGVTHVLNAAQGTKR---------------------------------------LSHVntdasFYKSGIIFHGIPATDVFMFKLNKYFDEAADF
 ..|  ||.|..... . . .                                       |...      ... .  ..|. ||   ... ..|... ||
wrmlwelgitvivmLtslvelgrekcaqywplggsleygdftvtllsvevkddytvrtleltnl.....ydgesrtvlhiqytdwpdhgvppsfedlldf

IASAVGTKNCP-KNGRVYVHCKEGISRSATLVLAYLI-----KHQQMGLTNALRTVRSKR-MVYPNMGFMEQLIDYSHK
|  .    .   |.|.|.|||. |..|..|...|||.     |.... | .|....||.| .. .| .....|... ..
ieavrkaleelpkggpvlVHCsaGvgRtGtfiaaylmleqlekelgvdleeavkllrsqRpgavqnpeqyrflyealle
subfamily_Dicty-DSP19-like_pd Subfamily Dicty-DSP19-like 40-183 6.4e-22 71.5 In-house 10-151 (154) alignment 
Range on Protein: 40-183
Range on HMM: 10-151/154.0
IYVGGAVTAMEEDQLVALGVTHVLNAAQGTKRLShvNTDASFYKSGIIFH--GIPATDVFMFKLNKYFDEAADFIASAVGTKncpKNGRVYVHCKEGISR
.|..   .|..  .|    ....|| . |.. |     . |  . |.|..   .   |   |.. . .| | .|| .|.|     .|..| ||...|.||
lyissfdaalnkldlqlkniksilnvgiGinnlf..tdensdindgfiieylnlelfddvnfdiiekldkafefiddaiggv...ennkvlvhsdkGvsr

SATLVLAYLIKHQQMGLTNALRTVRSKR-MVYPNMGFMEQLIDYSHK
||.|...||...... | .||  ... | .. || ||..||  .  .
saallisylmdklkislslalellkdsryiikPnqGflkqleifeke
0042113 (Phosphotyrosine protein) phosphatases II 35-180 1.3e-21 72.5 In-house 49-238 (245) alignment 
Range on Protein: 35-180
Range on HMM: 49-238/245.0
EVFDGIYVGGAVTAMEED----QLVALGVTHVLNAAQGTKR-------------------------------------LSHVNTDASFYKSGIIFHGIPA
.. ........ ..   .    .|  ||.|....  . . .                                     |. .|.  .... .| .| .| 
ritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywplgesltygdftvtllseehlddytvrtlevtnlgddesrevihyhylpw

TDVFMFKLNKYFDEAADFIASAVGTkncPKNGRVYVHCKEGISRSATLVLAYLI-----KHQQMGLTNALRTVRSKR-MVYPNMGFMEQLIDY
 |  .  | ...... .|. .|.     ..||.|.|||. |..|..|...|||.     |.. . | .|.. .||.| .. .. .....|...
pdhgvpdllellldflefvrkalae...dsngpvlVHCsaGvgRtGtfiaaylmleqlekelgvsleeavkelrsqRpgavqtpsqyrflyea
0045450 (Phosphotyrosine protein) phosphatases II 53-182 1.1e-20 70.1 In-house 126-301 (307) alignment 
Range on Protein: 53-182
Range on HMM: 126-301/307.0
QLVALGVTHVLNAAQGTKR-------------------LSHVNTDASFYKSGIIFHGIPATDV-----------------FMFKLNKYFDEAADFIASAV
.|  .|||....  . . .                     .|..    ...|.. . .. ||                    ... ..|.|. |||  . 
mlweqgvtvivmltelvelgrekcaqywPdegeeltygnftvtllseehldgytvrtlevtdldgtgesrtvthfhytgwpdhgvppsfeelldfieevr

GTKN-CPKNGRVYVHCKEGISRSATLVLAYLIKHQQ--------MGLTNALRTVRSKR-MVYPNMGFMEQLIDYSH
   . .||.|.|.|||. |..|..|...|||...|         . | .|....|..|  . .| .....|... .
kaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyeall
subfamily_MKPLT_pd Subfamily MKPLT 38-181 1.1e-19 64.6 In-house 27-157 (164) alignment 
Range on Protein: 38-181
Range on HMM: 27-157/164.0
DGIYVGGAVTAMEEDQLVALGVTHVLNAAQGTKrlshvntdASFYKSgIIFHGIPATDVFMFKLNKYFDEAADFIASAVGTkncpkNGRVYVHCKEGISR
| .| | |  | .|  | .| .||..| .|..|          | || . .  .   |.   .| .... ||.|.|.|. .      |||.|||  | ||
dtlylGnakhatnekvlkdlkithivnvsqekk........dafpks.veYlqvkvedesdeqlssfleraakfladaids.....GGrvlvhcvqGksr

SATLVLAYLIKHQQMGLTNALRTVRSKR-MVYPNMGFMEQLIDYS
|..  .|.||| ..  | .|   .. .| .| || ||. ||  . 
sssvtvafLikskgwtlkeayeylkerrsivapnrGflkqlakfe
subfamily_MKPLV_pd Subfamily MKPLV 38-181 1.1e-19 64.6 In-house 27-157 (164) alignment 
Range on Protein: 38-181
Range on HMM: 27-157/164.0
DGIYVGGAVTAMEEDQLVALGVTHVLNAAQGTKrlshvntdASFYKSgIIFHGIPATDVFMFKLNKYFDEAADFIASAVGTkncpkNGRVYVHCKEGISR
| .| | |  | .|  | .| .||..| .|..|          | || . .  .   |.   .| .... ||.|.|.|. .      |||.|||  | ||
dtlylGnakhatnekvlkdlkithivnvsqekk........dafpks.veYlqvkvedesdeqlssfleraakfladaids.....GGrvlvhcvqGksr

SATLVLAYLIKHQQMGLTNALRTVRSKR-MVYPNMGFMEQLIDYS
|..  .|.||| ..  | .|   .. .| .| || ||. ||  . 
sssvtvafLikskgwtlkeayeylkerrsivapnrGflkqlakfe
0040438 (Phosphotyrosine protein) phosphatases II 58-184 6.7e-19 63.7 In-house 110-275 (317) alignment 
Range on Protein: 58-184
Range on HMM: 110-275/317.0
GVTHVLNAAQGTKRL------------------SHVNTDASFYKSGIIFHGIPATDV----------------FMFKLNKYFDEAADFIASAVGTKNcPK
|||....  . . .                    .|..   ....||. . .. .|                   ... ...|.  ||.  .    . ..
gvtvivmLteleelgrekcaqYwplgetltygdftvtllseeelagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfleavreale.dp

NGRVYVHCKEGISRSATLVLAYLI-----KHQQMGLTNALRTVRSKRM-VYPNMGFMEQLIDYSHKL
.| | |||. |..|..|...|||.     |.... ...|....|..|. . .. .....|.|. ...
ggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalley
0038934 (Phosphotyrosine protein) phosphatases II 78-184 8.1e-19 63.5 In-house 72-176 (194) alignment 
Range on Protein: 78-184
Range on HMM: 72-176/194.0
DASFYKSGIIFHGIPATDVFM---FKLNKYFDEAADFIASAvgtkncPKNGRVYVHCKEGISRSATLVLAYLIKHQQMGLTNALRTVRSKR-MVYPNMGF
   |.|.|| .. .|  | .    ... . | ...|.. ..       ..| |.|||| |..|..||| ||||....| .  |....|.||  ..|| ..
peefekagieylklpfpddgtvPsleillrfldlvdeflne......dpggvvaVHCkaGlgRtGtlvaaYLiyrlgmsaeeAialfrekRpgaipnqdy

MEQLIDYSHKL
.|.|  . . |
leallkrykel
0039614 (Phosphotyrosine protein) phosphatases II 57-185 9.2e-19 63.4 In-house 124-289 (297) alignment 
Range on Protein: 57-185
Range on HMM: 124-289/297.0
LGVTHVLNAAQGTKR-----------------------------------LSHVNTDASFYKSGIIFHGIPatDVFMFKLNKYFDEAADFIASAVGTKnc
.|||....  . . .                                   |. .|.. |..   . ..|.|  |     . ....|. ... .|. .   
qgvtvivmLtklvelgrkcaqywpeeggtygdftvtllkvehldgytvrtlevtnngesrtvthfqytgwp..dhgvppslellleflelvrealael..

PKNGRVYVHCKEGISRSATLVLAYLI-----KHQQMGLTNALRTVRSKR-MVYPNMGFMEQLIDYSHKLN
||.|.|.|||. |..|..|...|||.     |.... . .|....|..| .. ........|.|. ..| 
pkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydallell
subfamily_PTPMT1_pd Subfamily PTPMT1 32-166 1.3e-18 62.0 In-house 19-149 (171) alignment 
Range on Protein: 32-166
Range on HMM: 19-149/171.0
AYDEVFDGIYVGGAVTAMEEDQLV-ALGVTHVLNAAQGTKRLSHVNTDASFYKSGIIFHGIPATDVFMFKLNKYFDEAADFIASAVGTKNcpkngRVYVH
 || . | ...|        ..|.    |  |..  .  .   ..|.  .. | |. .  .. .|..     .   .. .|| .   ...     |||||
wydriDdtvilGalPfrslikeLiekenvkavvslneeyelkalansteewkklgveqlqlatvDfteapdleklekgvefiekvaskgk.....rvYvH

CKEGISRSATLVLAYLIKHQQMGLTNALRTVRSKRM
|| | .|||||| .||.|.... . .||.....|| 
CkaGrgRsatlvacylmkkeklspeeAlkalkkkRk
0036941 (Phosphotyrosine protein) phosphatases II 74-184 3.1e-17 58.3 In-house 161-276 (297) alignment 
Range on Protein: 74-184
Range on HMM: 161-276/297.0
HVNTDASFYKSGIIFHGIPATDVFMfklnkYFDEAADFIASAVGT-KNCPKNGRVYVHCKEGISRSATLVLAYLI--------KHQQMGLTNALRTVRSK
..... |..   . ..|.|  .|       ....  |||  .    |. |..|.|.|||. |..||.|...|.|.        |.... . .|....|..
dtgngesrtvthfhytgwpdhgvpe.....spaslldfielvrkvlkllpsggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReq

R-MVYPNMGFMEQLIDYSHKL
| .. .. .....|...  .|
Rpgavqtleqyrflyeallel
subfamily_STYX_pd Subfamily STYX 32-181 6.1e-17 55.2 In-house 11-154 (166) alignment 
Range on Protein: 32-181
Range on HMM: 11-154/166.0
AYDEVFDGIYVGGAVTAMEE--DQLVALGVTHVLNAAQGTKRlSHVNtdaSFYKSGIIFHGIPATDVFMFKLNKYFDEAADFIASAVGtkncpKNGRVYV
  .|.. |...|   .||    ..|   |.||..   |  .  . .      ..  . .  .  .|  . .. .|. .  .|| ...      | |.| |
emqeilpglflgpysaamksklevlkkhgithivcirqniea.nlik...pnfpdrfrylvldvadntveniirylptvkefiddslq.....kggkvlv

HCKEGISRSATLVLAYLIKHQQMGLTNALRTVRSKRM-VYPNMGFMEQLIDYS
| . ||||||.||.||...   .   .| . |. .|. . || ||..|| .| 
hgnagisrsaalviayimetyglkyreafayvqerrfcinpnegfvsqlkeye
0043336 (Phosphotyrosine protein) phosphatases II 72-180 1.8e-16 55.9 In-house 164-272 (278) alignment 
Range on Protein: 72-180
Range on HMM: 164-272/278.0
LSHVNTDASFYKSGIIFHGIPATDVFMfKLNKYFDEAADFIASAVgtkncPKNGRVYVHCKEGISRSATLVLAYLI-----KHQQMGLTNALRTVRSKR-
...  .. |..  .. ..|.|  .|    |. ..|   ...         ..|| |.|||. |..|..|....||.     |.. . | .|....|..| 
vtnlgdgesrtvthyhylgwpdhgvpe.slsllldflkavreale.....dsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRp

MVYPNMGFMEQLIDY
.  ..  ....|...
gavqtpsqyrflyea
0051429 (Phosphotyrosine protein) phosphatases II 33-182 2e-16 55.9 In-house 16-222 (272) alignment 
Range on Protein: 33-182
Range on HMM: 16-222/272.0
YDEVFDG-IYVGGAV---TAMEEDQLVALGVTHVLNAAQGTKRLShvnTDASFYKSGIIFHGIPATDVFMFKLN--------------------------
. .| .| .| .|.    || . ..|  ||......  . . | .    . ..|  || .. .|  |   .  .                          
grvvkpgrlyrsggplpltaadfwrlkelgiktivdLrseeErgr...lkcdrywpgirylhlpilddsaptilygalrvtllseellldyilrellltl

-------------------------KYFDEAADFIASavgtkncpkNGRVYVHCKEGISRSATLVLAYLIKhQQMG--------------LTNALRTVRS
                         ... |. .....         .|.|.|||. |..|..|.|...|.  ....              | .|.. .|.
llsagearevmhlhytdwpdhgvpqeallellellld.........ggpvlvHCsaGkdRTGtvvalllll.lgvsletivddYlltnlyleeaveelra

KR-MVYPNMGFMEQLIDYSH
.|  . .. .....| ..  
qrpgavqteeqylflyeall
subfamily_STYXL1_pd Subfamily STYXL1 40-183 4.6e-14 45.9 In-house 19-152 (157) alignment 
Range on Protein: 40-183
Range on HMM: 19-152/157.0
IYVGGAVTAMEEDQLVALGVTHVLNAAQGTKRLSHVNTDasfyKSGiIFHgIPATDVFMFKLNKYFDEAADFIASAVGTKNCpkngrVYVHCKEGISRSA
.|.|    |...     | |  ..| .. ...| .  .|     .  ..| |.  |.   .| . ..|| .|| . . ....     | |  ..||||||
lylGnykqaqnpaikkdlkvkahvnvsmdadkliagvad....vak.llh.iavedeneadllerlkeavqfiekhkkegev.....vlvfsnkGisrsa

TLVLAYLIKHQQMGLTNALRTVRS-KRMVYPNMGFMEQLIDYSHK
....|||. .... | .|.  ..  |  | || .|.||| .. ..
aviiaylmyskkitlkkaykylkkCkenvkPnrafveqlseWekq
0047943 (Phosphotyrosine protein) phosphatases II 71-167 1.2e-13 46.6 In-house 156-253 (273) alignment 
Range on Protein: 71-167
Range on HMM: 156-253/273.0
RLSHVNTDASFYKSGIIFHGIPATDVF--MFKLNKYFDEAADFIAsavgtkNCPKNGRVYVHCKEGISRSATLVLAYLI-----KHQQMGLTNALRTVRS
.|....|. |..   . ..|.|  .|   .  | ...... ....      ..|.|| |.|||. |..|..|.....|.     |.... . .|.. .||
eltnlgtgesrtvthfhytgwpdhgvppslesllefielvrkale......alpsngpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrs

KRMV
.|. 
qRpg
0046845 (Phosphotyrosine protein) phosphatases II 72-169 1.5e-13 46.2 In-house 155-254 (284) alignment 
Range on Protein: 72-169
Range on HMM: 155-254/284.0
LSHVN-TDASFYKSGIIFHGIPATDVF--MFKLNKYFDEAADFIASavgtknCPKNGRVYVHCKEGISRSATLVLAYLIKHQ--------QMGLTNALRT
|.... |. |..   . ....|  .|   .  | ...... ... .      .|..| . |||. |..|..|.....|...|         . . .|.. 
ltnlgytgesrtvthfhytswpdhgvppspedlleflrlvrellen......lpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkr

VRSKRmvyP
.|..|   |
lreqR...p
subfamily_MSG5_pd Subfamily MSG5 123-185 9.6e-13 41.6 In-house 98-161 (165) alignment 
Range on Protein: 123-185
Range on HMM: 98-161/165.0
KNGRVYVHCKEGISRSATLVLAYLIKHQQMGLTNALRTVRSK-RMVYPNMGFMEQLIDYSHKLN
|. .. |||. |.||||.|..||..|. .. | .|   ..|.   . |..|.. ||...   |.
krkkilvhcqcglsrsaslivayimkyynlslrdaydklksvaddispsiglifqlmewevals
0051299 (Phosphotyrosine protein) phosphatases II 77-167 1.8e-12 42.8 In-house 178-267 (288) alignment 
Range on Protein: 77-167
Range on HMM: 178-267/288.0
TDASFYKSGIIFHGIP-----ATDVFMFKLNKYFDEAADfiasavgtkncPKNGRVYVHCKEGISRSATLVLAYLI-----KHQQMGLTNALRTVRSKRM
.. |..   . ....|      .   .... .....|             ...| |.|||. |..|..|.....|.     |.. . . .|....|..|.
dgesrtvthfhytnwpdhgvpdspellldflrlvrkala...........sgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRp

V
 
g
0050432 (Phosphotyrosine protein) phosphatases II 105-166 4.6e-12 41.3 In-house 216-279 (308) alignment 
Range on Protein: 105-166
Range on HMM: 216-279/308.0
FDEAADFIASAVGTKncpKNGRVYVHCKEGISRSATLVLAYLI-----KHQQMGLTNALRTVRSKRM
...  ||.  .  .    ..| ..|||. |..|..|.....|.     |.. . . .|....|..|.
peilldflelvrksl...pggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRp
subfamily_PTPDC1_pd Subfamily PTPDC1 79-166 1.5e-09 32.5 In-house 76-156 (182) alignment 
Range on Protein: 79-166
Range on HMM: 76-156/182.0
ASFYKSGIIFHGIPATDVFMFKLNKYFDeAADFIASAVgtkncpKNGRVYVHCKEGISRSATLVLAYLIKHQQMGLTNALRTVRSKRM
 .. ..||... .. .|  .. |.. .|     .|.|.      ..|.| |||  |  |   |. .||. ....   .|...||||| 
ealmeqgiyvynfgwkDygvasleriLd.ivkvvafal......qegkvavhChaGlGrtGvliacylvyakrltaekaiklvrskrp
0048567 (Phosphotyrosine protein) phosphatases II 120-175 1.7e-09 32.3 In-house 70-131 (157) alignment 
Range on Protein: 120-175
Range on HMM: 70-131/157.0
NCPKNGRVYVHCKEGI---SRSATLVLAYLIKHQQMGLTNALRTVRSKR---MVYPNMGFME
   ......|||| |    .|.|||. .|||.|...    |.. .|  |   ....  ....
lelagkaiavhckaglkkrgrtatLigcYlilhlgftpeeaiaplrivrpgsvpfrdasyll
PTPc_DSPc_SM00012 101-165 1.7e-08 30.0 In-house 15-86 (105) alignment 
Range on Protein: 101-165
Range on HMM: 15-86/105.0
LNKYFDEAADFIASAVGTKNCPK-NGRVYVHCKEGISRSATLVLAYLIKHQQ------MGLTNALRTVRSKR
. .. |.  .....    ||  . .. | |||. |..|..|.|..... .|       . . . .. .|..|
vPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqR
subfamily_DSP23_pd Subfamily DSP23 120-165 2.3e-08 28.8 In-house 80-125 (148) alignment 
Range on Protein: 120-165
Range on HMM: 80-125/148.0
NCPKNGRVYVHCKEGISRSATLVLAYLIKHQQMGLTNALRTVRSKR
   ||  | |||  |  |. |..  ||.|....  ..|.  || .|
aeekneavsvhcllgrgrtgtmlacylvkerklaaaeaiaevrrlr
subfamily_RNGTT_pd Subfamily RNGTT 125-165 1.7e-07 25.1 In-house 114-154 (189) alignment 
Range on Protein: 125-165
Range on HMM: 114-154/189.0
GRVYVHCKEGISRSATLVLAYLIKHQQMGLTNALRTVRSKR
  . |||. |  |.  |. .||........ .|... .. |
evigvhCthGfnRtGFlivsyLvekedwsveaavalFakaR
subfamily_CDC14_pd Subfamily CDC14 124-165 3.1e-07 24.6 In-house 263-307 (328) alignment 
Range on Protein: 124-165
Range on HMM: 263-307/328.0
NGRVYVHCKEGISRSATLVLAYLIKHQQMGLTNALRTVR---SKR
.| . |||| |. |  ||. .||.|| ..  ..|.  .|      
eGaiavhCkaGLGrtGtLiacylmkhyrftaaeaiawlricrPGs
Y_phosphatase Protein-tyrosine phosphatase 116-166 4.3e-06 21.7 Pfam-A 162-217 (235) alignment 
Range on Protein: 116-166
Range on HMM: 162-217/235.0
VGTKNCPKNGRVYVHCKEGISRSATLVLAYLIKHQQM-----GLTNALRTVRSKRM
| ... .|.| | |||..|..|..|.|.. .. .|        . ......|..|.
vekskeaksgpvvVhCsaGvgRtgtfvaldilleqleaeeevdvlqivkelRkqRp
Y_phosphatase Protein-tyrosine phosphatase 116-166 4.3e-06 21.7 In-house 162-217 (235) alignment 
Range on Protein: 116-166
Range on HMM: 162-217/235.0
VGTKNCPKNGRVYVHCKEGISRSATLVLAYLIKHQQM-----GLTNALRTVRSKRM
| ... .|.| | |||..|..|..|.|.. .. .|        . ......|..|.
vekskeaksgpvvVhCsaGvgRtgtfvaldilleqleaeeevdvlqivkelRkqRp
DSPc_SM00195 106-165 8.9e-06 20.6 In-house 188-241 (263) alignment 
Range on Protein: 106-165
Range on HMM: 188-241/263.0
DEAADFIasavgtkncpkNGRVYVHCKEGISRSATLVLAYLI-----KHQQMGLTNALRTVRSKR
..  . .           .| . |||. |..|..|.|.. .|     ..... . . .. .|..|
kksksts...........sgpivVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqR
PTPc_SM00194 106-165 8.9e-06 20.6 In-house 188-241 (263) alignment 
Range on Protein: 106-165
Range on HMM: 188-241/263.0
DEAADFIasavgtkncpkNGRVYVHCKEGISRSATLVLAYLI-----KHQQMGLTNALRTVRSKR
..  . .           .| . |||. |..|..|.|.. .|     ..... . . .. .|..|
kksksts...........sgpivVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqR
subfamily_DSP11_pd Subfamily DSP11 119-165 9.8e-06 19.6 In-house 111-157 (178) alignment 
Range on Protein: 119-165
Range on HMM: 111-157/178.0
KNCPKNGRVYVHCKEGISRSATLVLAYLIKHQQMGLTNALRTVRSKR
||  ..  . ||| .|. |.  |.  |||.....   .|...  . |
knkdndkligvhCthGvnrtGyliCrylidvegyepedaieafeear