Gene DSP8 in Nematostella vectensis

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family DSP
Subfamily DSP8
Protein sequence
ID Type Fasta BLAST phosphatome Note
NvecP013_AA protein Get Run
NvecP013_AA_150-297 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_DSP8_pd Subfamily DSP8 143-297 5e-74 241.1 In-house 3-158 (159) alignment
Range on Protein: 143-297
Range on HMM: 3-158/159.0
LSQPCLSTEA--PTHILPFLYLGTQEHSLDEEFLNATGINYVLNISCSCPALPGLENTGrYLRIPVKDTINENILDWFPTAFDFIDKVREVHGRVLLHCY
|||||||...  ||.||..||||.|...|.||.|...||.||||.|.|||.|  |...  .||.||||...|..|.||.....||||... .||||.|..
lsqPCLsvadvgptrilknlylGsqkdvlseellsklgisyvlnasnscpkleelkesk.flrvPvkDkydekllpwfdksvefidkaksengrvlvhvl

AGKSRSATIAIGYIMKHLRLSLDEAYRFVKERRPTISPNLNFMGQLMQYEKDLMITT
||.|||||.||.||||.|..|||||||||||.||||||||||.|||..|||.|...|
aGisrsatvaiayimktlemsldeayrfvkekrptispnlnflgqLleyekelkllt

subfamily_DSP10_pd Subfamily DSP10 148-294 3.1e-55 180.4 In-house 9-154 (159) alignment
Range on Protein: 148-294
Range on HMM: 9-154/159.0
LSTEAPTHILPFLYLGTQEHSLDEEFLNATGINYVLNISCSCPALPGLeNTGRYLRIPVKDTINENILDWFPTAFDFIDKVREVHGRVLLHCYAGKSRSA
. |   ...||||.|| .. . |.. |.  .|..|||. .|.|      .. .| ||||.|| ..|.   |  |..||...|.   |||.|| || ||||
ietapasqvlpfLflGsekdaadldaldrlnitavlnvttsvPnefee.ealkYkripvsDtskqnlkqyfeealefieearkkgsrvLvhCqaGisrsa

TIAIGYIMKHLRLSLDEAYRFVKERRPTISPNLNFMGQLMQYEKDLM
|..|.|.||||.||| .||.||||.||.|||||||||||...||.| 
tvviaYlmkhlnlslndaykfvkekrpiisPnLnfmGqLlefekeln

subfamily_DSP6_pd Subfamily DSP6 150-295 5.3e-50 163.0 In-house 11-156 (158) alignment
Range on Protein: 150-295
Range on HMM: 11-156/158.0
TEAPTHILPFLYLGTQEHSLDEEFLNATGINYVLNISCSCPALPGLENTGRYLRIPVKDTINENILDWFPTAFDFIDKVREVHGRVLLHCYAGKSRSATI
.|.| .|||.||||..... . | |.  .|.||||.    |     ..  .||.||..| ...|.  .|| |..|||. |. .  ||.||.|| ||| |.
aefpveilpllylGsakdasnlevlkklkikyvlnvtsnlpnkfeesgelkylqipiedhlsqnlakffPeaiefidearskkskvlvhClaGisrsvtv

AIGYIMKHLRLSLDEAYRFVKERRPTISPNLNFMGQLMQYEKDLMI
.. |.||.| |||..|| .||.|.. ||||.||||||...|. | .
tlaylmkklalslndaydlvkkrksnisPnfnfmgqlldferslrl

subfamily_DSP1_pd Subfamily DSP1 152-297 1.1e-46 152.9 In-house 16-160 (163) alignment
Range on Protein: 152-297
Range on HMM: 16-160/163.0
APTH-ILPFLYLGTQEHSLDEEFLNATGINYVLNISCSCPALpgLENTGRYLRIPVKDTINENILDWFPTAFDFIDKVREVHGRVLLHCYAGKSRSATIA
 |.. ||.|||||..... . |.|...||  .||.| ...     |.. .| .....|. ...|  .| .. .|||.|.. .|.||.|| || |||.|. 
dPvekildfLylGsetvasnleiLkslgitailnvskeldnv..fedlfeYkklkleDspkadislvfeeviefidevkkknGkvlihCqaGisRsstlc

IGYIMKHLRLSLDEAYRFVKERRPTISPNLNFMGQLMQYEKDLMITT
. |.||. |.||.||. |||.||. ||||..|..||..|||.|. ..
laylmktkrvsleeafdfvkqrRsiisPnagFvlqLlnyekklllel

PTPc_motif_SM00404 153-291 1.3e-40 133.5 In-house 2-139 (140) alignment
Range on Protein: 153-291
Range on HMM: 2-139/140.0
PTHILPFLYLGTQEHSLDEEFLNATGINYVLNISCSCPALpgL-ENTGRYLRIPVKDTINENILDWFPTAFDFIDKVREVHGRVLLHCYAGKSRSATIAI
|. ||| ||||..... ....|.. || .|.|.. ....     ..  ..|.||..|. ......... . |||..... .|.|| ||.|| |||||..|
psrilphlylgskskaqnpallkklgithvinvteevslt..kensgfqilqiplddnekdklskyldkvldfienaekkggkvlVHCqaGvSRSatlii

GYIMKHLRLSLDEAYRFVKERRPTISPNLNFMGQLMQYEK
 |.|.   |||.|||.|||||||.|||||||. ||..|||
aYlmryrqlslaeayefvkerRpiispnlnfvrqLieyek

DSPc Dual specificity phosphatase, catalytic domain 160-291 5.3e-39 128.1 Pfam-A 1-132 (133) alignment
Range on Protein: 160-291
Range on HMM: 1-132/133.0
LYLGTQEHSLdEEFLNATGINYVLNISCSCPAL-PGLENTGRYLRIPVKDTINENILDWFPTAFDFIDKVREVHGRVLLHCYAGKSRSATIAIGYIMKHL
||||.....  ...|.. ||..|.|.. ..|.     ..  .||||||.|. ...| .... | .||.|... ...|| ||.|| |||||..| |.||  
lylgskstas.lalleklgitlvinvtkevpnnnaikkseieylripvedetetkiskeleeavefiekaeqkgkkvlVHCqaGisRSatliiaYlmktk

RLSLDEAYRFVKERRPTISPNLNFMGQLMQYEK
.|||.|||.||||||..|||| .|..||..||.
nlslneAyefvkerrskispnagflrqLleyer

DSPc Dual specificity phosphatase, catalytic domain 160-291 5.3e-39 128.1 In-house 1-132 (133) alignment
Range on Protein: 160-291
Range on HMM: 1-132/133.0
LYLGTQEHSLdEEFLNATGINYVLNISCSCPAL-PGLENTGRYLRIPVKDTINENILDWFPTAFDFIDKVREVHGRVLLHCYAGKSRSATIAIGYIMKHL
||||.....  ...|.. ||..|.|.. ..|.     ..  .||||||.|. ...| .... | .||.|... ...|| ||.|| |||||..| |.||  
lylgskstas.lalleklgitlvinvtkevpnnnaikkseieylripvedetetkiskeleeavefiekaeqkgkkvlVHCqaGisRSatliiaYlmktk

RLSLDEAYRFVKERRPTISPNLNFMGQLMQYEK
.|||.|||.||||||..|||| .|..||..||.
nlslneAyefvkerrskispnagflrqLleyer

0044763 (Phosphotyrosine protein) phosphatases II 152-294 1.2e-38 127.8 In-house 22-171 (178) alignment
Range on Protein: 152-294
Range on HMM: 22-171/178.0
APTHILPFLYLGTQEHSLDEEFLNATGINYVLNISCSC-------PALPGLENTGRYLRIPVKDTINENILDWFPTAFDFIDKVR-EVHGRVLLHCYAGK
 ...|||.||||.. .. | |.| . ||....|..  .       ..    |.  .||.||. |  . ..|..|. ...||.... | .|.|| ||.||.
naseilpglylgslppaddlellkelgithivnlteelelgflkcdpywpeeagiqylhipipDhgvpdllehflefvefieealdekggpvlVHCsaGv

SRSATIAIGYIMKHLRLSLDEAYRFVKERRPtISPNLNFMGQLMQYEKDLM
.||.|... |.||.|.|||.||...|.|||| |.|| ... ||...|. |.
gRsgtlvaaylmkklglsleeaielvrerRp.ivpnpgqlrqLyefelrll

subfamily_DSP14_pd Subfamily DSP14 154-297 1.7e-38 126.0 In-house 8-148 (157) alignment
Range on Protein: 154-297
Range on HMM: 8-148/157.0
THILPFLYLGtQEHSLDEEFLNATGINYVLNISCSCPAlPGLENTGrYLRIPVKDTINENILDWFPTAFDFIDKVREVHGRVLLHCYAGKSRSATIAIGY
..| | |.|.    .|..| |....|. ..|..   |. . |..   ....||.|. .... ..| .. | |..|.. .|..|.||.|| ||||.... |
sqitpsLfls.gvaalskellkkkkitliinvtvelpn.tklkdie.rvkvpveDnpeaklakhfdevadkieevkkkggktlvhCvaGvSRSAslclay

IMKHLRLSLDEAYRFVKERRPTISPNLNFMGQLMQYEKDLMITT
.||. .||| |||. ||..|| |.||. |  ||..||| |  ..
lmkyeklsLreayklvksaRpiirPNvGFwkqlidyEkklkgks

subfamily_DSP19_pd Subfamily DSP19 155-293 2.2e-38 126.0 In-house 14-150 (152) alignment
Range on Protein: 155-293
Range on HMM: 14-150/152.0
HILPFLYLGTQEHSLDEEFLNATGINYVLNISCSCPALpgLENTGRYLRIPVKDTINENILDWFPTAFDFIDKVREVHGRVLLHCYAGKSRSATIAIGYI
.. | |||| |.   |.| |. ..| ..||..   | .    .   || |.. |. ....|.....|.|||...|. .|.||.|| || ||||...|.|.
eveprlylgsqdvaadkeilkekkitHilnvatgvpnv..fpkdftylsieilDlpetdllsylkealdFieearskdgavlvHCnAGvSRsasvviayl

MKHLRLSLDEAYRFVKERRPTISPNLNFMGQLMQYEKDL
||. .||| ||.. |.| ||.|.||  |. || .||. |
mkkeelsleealelvrearpcikPneGFikqLkeyeael

0048179 (Phosphotyrosine protein) phosphatases II 153-291 5.2e-35 115.6 In-house 4-142 (144) alignment
Range on Protein: 153-291
Range on HMM: 4-142/144.0
PTHILPFLYLGTQEHSLDEEFLNATGINYVLNISCSCPALPGLENTGRYLRIPVKDTINENILDWFPTAFDFIDKVREVHGRVLLHCYAGKSRSATIAIG
|. ||| |||| . ..|| |.| . ||..|.|.. ...      .  .||..|. |    ..|........||....| .|.|| ||.||..|..|... 
pseilpglylgslptaldlellkklgittvinlteeyepefleregiqylhlpwpDhgvpdllellleflefieealeeggpvlVHCsaGvgRtgtlvaa

YIMKHLRLSLDEAYRFVKERRPTISPNLNFMGQLMQYEK
|.||.|.|||.||...|..||| . || ... .|..|||
ylmkklglsleealalvrsrrpgavpnpgqlrfLleyek

subfamily_Slingshot_pd Subfamily Slingshot 150-293 1.8e-34 112.6 In-house 16-157 (169) alignment
Range on Protein: 150-293
Range on HMM: 16-157/169.0
TEAPTHILPFLYLGTQEHSLDEEFLNATGINYVLNISCSCPALpgLENTGRYLRIPVKDTINENILDWFPTAFDFIDKVREVHGRVLLHCYAGKSRSATI
 .....|  ..|||..  . . | |. .|..|.||... .      ... .||.| | |. ....|... ....||.|... . .||.||  | ||||..
ldsaskifdhvylGsewnasnleelkengveyilnvtkeidnf..fpekfeylnirvydeeetdllkywnetykfiekakkkgskvlvhckmGvsrsast

AIGYIMKHLRLSLDEAYRFVKERRPTISPNLNFMGQLMQYEKDL
 | | ||. .|||.||...|||||  | || .|. || .||  |
viayamkeyglsleealeyvkerrsvikPnkgflkqleeyeGil

0048076 (Phosphotyrosine protein) phosphatases II 153-293 4.1e-34 112.7 In-house 4-142 (145) alignment
Range on Protein: 153-293
Range on HMM: 4-142/145.0
PTHILPFLYLGTQEHSLDEEFLNATGINYVLNISCSCPALPglENTGRYLRIPVKDTINENILDWFPTAFDFIDKVREVHGRVLLHCYAGKSRSATIAIG
|. ||| |||| . . || |.|   || .|||... .. |   ..  .||..|. |    ..|........||..... .|.|| ||.||..|..|... 
pseilpglylgslptaldlellkdlgittvlnltselelle..rlgiqylylpwpDhgvpdllellleflefieealkeggpvlVHCsaGvgRtgtlvaa

YIMKHLRLSLDEAYRFVKERRPTISPNLNFMGQLMQYEKDL
|.|..|..||.||...|...|| . || ... .|...|. |
ylmlllgvsleealelvrsqrpgavpnpgqlrflyefelel

subfamily_DSP12_pd Subfamily DSP12 155-294 5.3e-34 111.9 In-house 4-144 (155) alignment
Range on Protein: 155-294
Range on HMM: 4-144/155.0
HILPFLYLGTQEHSLDEEFLNATGINYVLNISCS-CPALPGLENTGRYLRIPVKDTINENILDWFPTAFDFIDKVREVHGRVLLHCYAGKSRSATIAIGY
.||| ||||. |.  .||.|. ..|. || .     |     ... ... |.. |. .|.||.....|.|||.. .| .| || ||.|| |||.|| | |
rilpglylggleavqeeellkelkithvlsvikeelpehklkkgkvstkfiqilDepeediLshldeavdFieealeeegavlvHCqagvSRSvtiviAY

IMKHLRLSLDEAYRFVKERRPTISPNLNFMGQLMQYEKDLM
.||. .|||..|...||| .|.|.|| .|. ||  .||  .
lmkkeklslekAlklvkekkpeiepNegFleQLklfekmgc

0049772 (Phosphotyrosine protein) phosphatases II 165-293 1.7e-33 112.1 In-house 157-273 (314) alignment
Range on Protein: 165-293
Range on HMM: 157-273/314.0
QEHSLDEEFLNatginyvlniSCSCPAlPGLENT-GRYLRIPVKDtINENILDWFPTAFDFIDKVrEVHGRVLLHCYAGKSRSAT-IAIGYIMKHLRLSL
. .  | |.|.          .. ... . .|..  .|||||| |  ....|..|. ...||... . .|.|| || |||.|..| ....|.||.|..||
eptaadlellk..........eelydp.elferlgikylripvpD.gsaplledfdeflefieea.dkggpvlvHCkaGkgRtgtfvvaaylmkllgvsl

DEAYRFVKERRPtISPNLNFMGQLMQYEKDL
.||...|...|| |.|| .|. ||.|||. |
eealedvrlkRp.inpnpgfieqleqyefil

0041856 (Phosphotyrosine protein) phosphatases II 152-294 1.2e-31 105.1 In-house 18-173 (182) alignment
Range on Protein: 152-294
Range on HMM: 18-173/182.0
APTHILPFLYLGTQEH--------------SLDEEFLNATGINYVLNISCSCPALPGLENTG-RYLRIPVKDTINENildwFPTAFDFIDKVREVHGRVL
 .. |.. |||| . .                . ..|   ||....|... .     ||..| .||..|. |    .    .....|||..|.| .|.||
dldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlteelywpellerlgiqylylpwpDhgvpd....ldelldfieevleeggpvl

LHCYAGKSRSATIAIGYIMKHLRLSLDEAYRFVKERRP--TISPNLNFMGQLMQYEKDLM
 || ||..|..|... |.||.|..||.||...|..|||   |.|| .|. ||. .|. | 
VHCsaGvgRtgtlvaaylmkklgvsleeavklvrsrRpgmvitpnqyfflqlallellll

0043147 (Phosphotyrosine protein) phosphatases II 153-294 1.5e-30 101.5 In-house 19-161 (172) alignment
Range on Protein: 153-294
Range on HMM: 19-161/172.0
PTHILPFLYLGTQEHSLDEEFLNATGINYVLNIScSC--PALPGLENTGRYLRIPVKDTINEnILDWFPTAFDFIDK--VREVHGRVLLHCYAGKSRSAT
|..........   .. . ..|   ||....|.  ..  .. .  ..  .||..|. |     .|.... ...|||.  ... .|.|| ||.||..|..|
pdrfiatqgplrntladfwrmlkelgithivnlt.ellydpellerlgiqylylpwpDhgvp.llellleflefidellalspggpvlVHCsaGvgRtgt

IAIGYIMKhLRLSLDEAYRFVKERRPTISPNLNFMGQLMQYEKDLM
... |.|. |.|||.||...|.|.|| ...| ... .|...|| |.
lvaaylml.lglsleeavalvrekRpgavqnpsqyrflyyfeklll

subfamily_LRR-DSP_pd Subfamily LRR-DSP 148-296 1.6e-30 100.1 In-house 115-261 (263) alignment
Range on Protein: 148-296
Range on HMM: 115-261/263.0
LSTEAPTHILPFLYLGTQEHSLDEEFLNATGINYV-LNISCSCPALPgleNTGRYLRI-PVKDTINENILDWFPTAFDFIDKVREvHGRVLLHCYAGKSR
| .  |  |.. |.||... . .. .|.  |. .. | ..   |  |   .. .|| |  ..|. . .|  .|     ||.. |. .| ||.|| || ||
lvssvPdeiidklflGgldsannksilkdlgvthillavadfePlfP...klfkylsiddiedvdeadisqhfeetnafieeGrk.kGGvlvhcraGvsr

SATIAIGYIMKHLRLSLDEAYRFVKERRPTISPNLNFMGQLMQYEKDLMIT
|.|. | |.||. || . ||. .|...|| | ||  |. ||..|||.|. |
sstlvisylmkkqrlkfkealdlvikkrpriqPnpGfkdqlkkyekklfct

subfamily_Choan-DSP_MKP-1_pd Subfamily Choan-DSP_MKP-1 157-291 2.8e-29 95.5 In-house 11-145 (148) alignment
Range on Protein: 157-291
Range on HMM: 11-145/148.0
LP-FLYLGTQEHSLDEEFLNATGINYVLNISCSCPALpgLENTG-RYLRIPVKDTINENILDWFPTAFDFIDKVREVHGRVLLHCYAGKSRSATIAIGYI
 . ||.|| ... .| | |.| |.  . | . ...    |.. | .|| ....|  .|..   |... .|..|...  .|||.|.  | |||. .|. ..
kdafLFlGskksaadlealkalgvtrivnatkerdna..ldqrgieYlhvaldDkpkedlsaiFediiafvrkakdeGrrvLvhlqmGvsrssalallwl

MKHLRLSLDEAYRFVKERRPTISPNLNFMGQLMQYEK
... | || ||. .||..|. . ||| |. || ..|.
idfkrvslkealalvkskrryvdpnlgfLkqLaeleq

subfamily_Dicty-DSP19-like_pd Subfamily Dicty-DSP19-like 157-293 5.3e-29 94.5 In-house 7-152 (154) alignment
Range on Protein: 157-293
Range on HMM: 7-152/154.0
LPFLYLGTQEHSLDEEFLNATGINYVLNISCSCPALPGLE----NTG---RYLRIPVKDTINENILDWFPTAFDFIDKVR-E-VHGRVLLHCYAGKSRSA
  |||..... .|.   |.   |. .||..   . |   |    | |    ||.. . | .| .|.. .  ||.|||.      ...||.|. .| ||||
aiflyissfdaalnkldlqlkniksilnvgiGinnlftdensdindgfiieylnlelfddvnfdiiekldkafefiddaiggvennkvlvhsdkGvsrsa

TIAIGYIMKHLRLSLDEAYRFVKERRPTISPNLNFMGQLMQYEKDL
...|.|.|..|..|| .|. ..|. |. |.||  |. || ..||.|
allisylmdklkislslalellkdsryiikPnqGflkqleifekel

0049260 (Phosphotyrosine protein) phosphatases II 153-292 6.9e-29 95.9 In-house 8-148 (152) alignment
Range on Protein: 153-292
Range on HMM: 8-148/152.0
PTHILPFLYLGTQEHSLDEEFLNATGINYVLNISCSCP-ALPGLENTGRYLRIPVKDTINENILDWFPTAFDFIDK-VREVHGRVLLHCYAGKSRSATIA
|.........| . .. . ..|   ||......   .. . .. |.  .||..|. |    .. .... ...||.|  .. .|.|| ||.||..|..|..
pfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyiqylhlpwpDhgvpdlsqlllflllfieklaldkggpvlVHCsaGvgRtgtlv

IGYIMKhLRLSLDEAYRFVKERRPTISPNLNFMGQLMQYEKD
. |.|. |..||.||...|.|.|| . || ... .|...|| 
aaylml.lgvsleeavalvrekRpgavpnpgqlrflyefekl

subfamily_DSP15_pd Subfamily DSP15 155-292 7.3e-29 94.8 In-house 4-138 (151) alignment
Range on Protein: 155-292
Range on HMM: 4-138/151.0
HILPFLYLGTQEHSLDEEFLNATGINYVLNISCscPALPGLENtGRYLRIPVKDTINENILDWFPTAFDFIDKVREVHGRVLLHCYAGKSRSATIAIGYI
..|| ||||  . | ||| |. . |  .|...    | . |..  .|. |...|| . ..  .|  . .|| | |   . ||.|| || |||.|... |.
kvlpglylgnfrdskdeelLkeknithilsvhd..nakkllkd.ieYkciaasDtpsaklskffkesvefihkcRlkeenvlvhClaGvsRsvtlvvaYl

MKHLRLSLDEAYRFVKERRPTISPNLNFMGQLMQYEKD
|  . |.  .| ...|..| .  ||. |  ||..||| 
mtvtelnwrdalevikaaRsvanPnfGfkrqlkeyekt

PTEN_1 144-293 2.1e-28 94.5 In-house 37-191 (196) alignment
Range on Protein: 144-293
Range on HMM: 37-191/196.0
SQPCLSteaptHILPFLYLGTQEHS-LDEEFLNATGINYVLNISCSCPAlPG--------LENTGRYLRIPVKDTINENILDWFPTAFDFIDKVRE--VH
|.|.|.     .| ..||.| ...   | . | . ||  |.| |. ..  .|         ..  .||..|..|    ..  .|  . .||. ...   .
srpllq.....eideglyrgslkdvaadldnlkedgitlvvnlseeeel.sgrsydleeffksgveylhfpieDhgapslselfdicksfiewllsdpng

GRVLLHCYAGKSRSATIAIGYIMKHLRLSLDEAYRFVKERRPTISPNLNFMGQLMQYEKDL
. || || ||..||.|... | |.. .|. ||| ..|.|.|| ..||  .. .|..|...|
nvVlVHCkaGlgRsGtvvaayLmykgkltadeAlelvrekRppgapnspsqerlleyfael

subfamily_DSP3_pd Subfamily DSP3 155-294 2.5e-28 92.7 In-house 13-158 (162) alignment
Range on Protein: 155-294
Range on HMM: 13-158/162.0
HILPFLYLGTQEHSLDEEFLNATGINYVLNISCScpAL----PG----LENTGRYLRIPVKDTINENILDWFPTAFDFIDKV-REVHGRVLLHCYAGKSR
 . | ||.| .. . |.. |.. || .||| . .   .     |     .   .|| ..|.|. . ..  .| ||..|||.   . .|.||.|| .| ||
evypklyvgdeavakdkskLkklGithvlnaaeg..rfskvdtgaefykdleikylGlevdDvpefdlskyFetaakfidealsqkegkvlvhcvvGvsR

SATIAIGYIMKHLRLSLDEAYRFVKERRpTISPNLNFMGQLMQYEKDLM
|||... |.| . ...| || | |...| .| ||  |. ||......|.
satlvlayLmirrkmtlveairtvrkkR.eilPneGFlkqLaeldeelk

subfamily_STYX_pd Subfamily STYX 155-293 5.5e-28 91.1 In-house 14-157 (166) alignment
Range on Protein: 155-293
Range on HMM: 14-157/166.0
HILPFLYLGTQEHSLD--EEFLNATGINYVLNISCSCPA---LPGLENTGRYLRIPVKDTINENILDWFPTAFDFIDKVREVHGRVLLHCYAGKSRSATI
.||| |.||    ..    | |.  || ... |  .  |    | .... ||| . | |.  |||. ..||  .|||.  .  |.||.|  || ||||..
eilpglflgpysaamksklevlkkhgithivcirqnieanlikpnfpdrfrylvldvadntveniirylptvkefiddslqkggkvlvhgnagisrsaal

AIGYIMKHLRLSLDEAYRFVKERRPTISPNLNFMGQLMQYEKDL
 |.|||.   |   ||...|.|||  |.||  |. ||..||   
viayimetyglkyreafayvqerrfcinpnegfvsqlkeyeaiy

0046846 (Phosphotyrosine protein) phosphatases II 152-292 4.6e-26 87.1 In-house 11-171 (176) alignment
Range on Protein: 152-292
Range on HMM: 11-171/176.0
APTHILPFLYLGTQE----------HSLDEEFLNATGINYVLNISCS-------CPALPGL--ENTGRYLRIPVKDTINENIlDWFPTAFDFIDKVREVH
 .. |.. |.||             .  . |.|   ||..|.|.          || .. .  ..  .||..|. |    .. ........||..... .
dldyinanlilgsrpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgiqylhlpwpDhgvpdl.elllellefirealkeg

GRVLLHCYAGKSRSATIAIGYIMKH-LRLSLDEAYRFVKERRP-TISPNLNFMGQLMQYEKD
|.|| ||.||..|..|... |....   ||..||...|.|.||  . .. ... .|...|. 
gpvlVHCsaGigRtgtlvaayllelekglsveealalvreqRplgavqtpeQyrflyefell

subfamily_MKPLT_pd Subfamily MKPLT 159-291 6.4e-26 84.8 In-house 28-158 (164) alignment
Range on Protein: 159-291
Range on HMM: 28-158/164.0
FLYLGTQEHSLDEEFLNATGINYVLNISCSCpaLPGLENTGRYLRIPVKDTINENILDWFPTAFDFIDKVREVHGRVLLHCYAGKSRSATIAIGYIMKHL
 ||||  .|. .|. |..  |....|.|  .  .    ..  ||.. |.|. .|.. ...  | .|. .  .  ||||.||  |||||..... ...|  
tlylGnakhatnekvlkdlkithivnvsqek..kdafpksveYlqvkvedesdeqlssfleraakfladaidsGGrvlvhcvqGksrsssvtvafLiksk

RLSLDEAYRFVKERRPTISPNLNFMGQLMQYEK
.  |.||| ..||||  ..||  |. || ..|.
gwtlkeayeylkerrsivapnrGflkqlakfee

subfamily_MKPLV_pd Subfamily MKPLV 159-291 6.4e-26 84.8 In-house 28-158 (164) alignment
Range on Protein: 159-291
Range on HMM: 28-158/164.0
FLYLGTQEHSLDEEFLNATGINYVLNISCSCpaLPGLENTGRYLRIPVKDTINENILDWFPTAFDFIDKVREVHGRVLLHCYAGKSRSATIAIGYIMKHL
 ||||  .|. .|. |..  |....|.|  .  .    ..  ||.. |.|. .|.. ...  | .|. .  .  ||||.||  |||||..... ...|  
tlylGnakhatnekvlkdlkithivnvsqek..kdafpksveYlqvkvedesdeqlssfleraakfladaidsGGrvlvhcvqGksrsssvtvafLiksk

RLSLDEAYRFVKERRPTISPNLNFMGQLMQYEK
.  |.||| ..||||  ..||  |. || ..|.
gwtlkeayeylkerrsivapnrGflkqlakfee

subfamily_STYXL1_pd Subfamily STYXL1 153-294 2.8e-24 79.1 In-house 11-154 (157) alignment
Range on Protein: 153-294
Range on HMM: 11-154/157.0
PTHILP-FLYLGTQEHSLDEEFLNATGINYVLNISCSC-PALPGLENTGRYLRIPVKDTINENILDWFPTAFDFIDKVREVHGRVLLHCYAGKSRSATIA
|  .|| .||||. ... ...  .   .  ..|.|  . . . |.... . |.|.|.|. . ..|. .  | .||.| ..    ||.    | ||||...
PvevlPgklylGnykqaqnpaikkdlkvkahvnvsmdadkliagvadvakllhiavedeneadllerlkeavqfiekhkkegevvlvfsnkGisrsaavi

IGYIMKHLRLSLDEAYRFVKERRPTISPNLNFMGQLMQYEKDLM
|.|.| . ...| .|| ..|. .. . || .|. || ..||.|.
iaylmyskkitlkkaykylkkCkenvkPnrafveqlseWekqll

0036282 (Phosphotyrosine protein) phosphatases II 154-291 3.7e-24 80.8 In-house 13-167 (174) alignment
Range on Protein: 154-291
Range on HMM: 13-167/174.0
THILPFLYLGTQEHSlDEEFLNATGINYVLNISCSCPAL-------------PGLENTGRYLRIPVKDTINENILDwFPTAFDFIDKVREV--HGRVLLH
..|.| |..|   .. . |.|   ||..|..   ...                  ..  .||..|. |    ..   . ....|......   .| || |
syitprliagqgpla.fwemlkelgittvvmlleekelglykcinywpelredlerlgiqylylpwpDhgvpdlsi.llefvkfveealsedpggpvlVH

CYAGKSRSATIAIGYIMKHLRL-SLDEAYRFVKERR---PTISPNLNFMGQLMQYEK
| ||..|..|... |.|... | ||..|...|.|.|   | . .. ... .| ..||
CsaGvgRtGtlvaaylmlrglleslvdaldlvrelRlqrpgmvqtpsQyrflyyfek

0045098 (Phosphotyrosine protein) phosphatases II 145-293 4.9e-24 80.6 In-house 14-271 (278) alignment
Range on Protein: 145-293
Range on HMM: 14-271/278.0
QPCLSTEAPTHILPFLYLGTQE-----------------------------------------HSLDEEFLNATGINYVLNISCSCPA------------
.  |..  |  |.|.|||| ..                                         .. . ..|   ||......    .             
efllllgipseitpalylgnldknRykdilpydhsrVkdYINAsyidgypkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrekcaqywpeg

-----------------------------------LPGLENTGR---YLRIPVKDTINENILDWFPTAFDFIDKVRE--------------VHGRVLLHC
                                     . ... .   || .|  .. ...||..|  ...||.....               .|.|| ||
gsltygdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsggpvlVHC

YAGKSRSATIAIGYIMKHL---RLSLDEAYRFVKERRPT-ISPNLNFMGQLMQYEKDL
.||..|..|... |.|..|   ...|.||.......||  . .||... .|.... .|
saGvgRtGtlvaaylmlelleggvdlleavkelrsqRpglavqnleqyrflyefllel

0037934 (Phosphotyrosine protein) phosphatases II 155-293 2.5e-23 78.3 In-house 41-241 (243) alignment
Range on Protein: 155-293
Range on HMM: 41-241/243.0
HILPFLYLGTQ--------EHSLDEEFLNATGINYVLNISCSC------------------------------------------PA-LPGLENTGRYLR
 ..| |... .         .  . ..|   ||......   .                                          .   .   .  .|..
yvtprliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywpgevtygdftvtllseehlddytvrtlllenldlddltrlvihyhy

IPVKD----TINENILDWFPTAFDFIDK-----VREVHGRVLLHCYAGKSRSATIAIGYIMKHL-RLSLDEAYRFVKERRPT-ISPNLNFMGQLMQYEKD
.|. |    .  |..||..  . .||..     ..  .|.||.||.||..|..|... |.|..| ...|.||.....|.||  . ...... .|..... 
lpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRtGtliaaylmllllgvdleeavkllreqRpgkavqtpsqyrflyealle

L
|
l

0045450 (Phosphotyrosine protein) phosphatases II 199-293 3.5e-23 78.2 In-house 178-303 (307) alignment
Range on Protein: 199-293
Range on HMM: 178-303/307.0
GRYLRIPVKDT-----------------INENILDWFPTAFDFIDKVRE------VHGRVLLHCYAGKSRSATIAIGYIMKHLR--------LSLDEAYR
  .....|.|.                  . .. ..| ...|||..||.       .|.|| || ||..|..|... |.|....        ..|.||..
ytvrtlevtdldgtgesrtvthfhytgwpdhgvppsfeelldfieevrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavk

FVKERRPTISPNLNFMGQLMQYEKDL
...|.|| . .|.... .|......|
llreqRpgavqnpeqyrflyeallel

0040439 (Phosphotyrosine protein) phosphatases II 178-293 4.2e-23 77.7 In-house 78-245 (249) alignment
Range on Protein: 178-293
Range on HMM: 78-245/249.0
GINYVLNISCSCPA--------LP---------------------------------GLENTGRYLRIPVKDTINENILDWFPTAFDFIDKVRE------
||.......  ..          |                                 .  .. ..| |.. |    .. ..|....|||..||.      
gitvivmLtslvelgrekcaqywplggsleygdftvtllsvevkddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelp

VHGRVLLHCYAGKSRSATIAIGYIM-----KHLRLSLDEAYRFVKERRPTISPNLNFMGQLMQYEKDL
 .|.|| || ||..|..|... |.|     |.|...|.||.......|| . .|.... .|......|
kggpvlVHCsaGvgRtGtfiaaylmleqlekelgvdleeavkllrsqRpgavqnpeqyrflyeallel

0051082 (Phosphotyrosine protein) phosphatases II 155-290 3.2e-22 74.2 In-house 10-150 (151) alignment
Range on Protein: 155-290
Range on HMM: 10-150/151.0
HILPFLYLGTQEHSLDEEFLNATGINYVLNISCSCPALPGL----ENTGRYLRIPVKDTINENILDWFPTAFDFIDKVREV-HGRVLLHCYAGKSRSATI
 . ..||.. . .. . |.|   ||....|.    .         |.  ..|.||. |. . .. ..|... .|......  .| || || |||.|..|.
yvtgglyrsggpladflellkelgiktivnlrseeergycpeylpelgievlhipildwpdpglplsfdavleflellldkkngpvlvHCsaGkgRTGtl

AIGYIMKhLRLSLDEAYRFVKERRP-TISPNLNFMGQLMQYE
.. |.|. |..||.||.......||  . ||  |. ||....
valylml.lgvsleealeeyrlkrpgvvqpnqqflfqlfall

0040438 (Phosphotyrosine protein) phosphatases II 199-301 4.4e-22 74.2 In-house 156-283 (317) alignment
Range on Protein: 199-301
Range on HMM: 156-283/317.0
GRYLRIPVKDT----------------INENILDWFPTAFDFIDKVREV----HGRVLLHCYAGKSRSATIAIGYIM-----KHLRLSLDEAYRFVKERR
  .....|.|.                   .. ... . .||...|||.    .| || || ||..|..|... |.|     |. .....||.....|.|
itlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfleavrealedpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqR

PTISPNLNFMGQLMQYEKDLMITTTEKK
| . ...... .|.... ... ..  ..
pgavqtpeqyrflydalleylkrkltle

0042113 (Phosphotyrosine protein) phosphatases II 156-293 1.8e-21 72.1 In-house 50-242 (245) alignment
Range on Protein: 156-293
Range on HMM: 50-242/245.0
ILPFLYLGTQEHSLDEE----FLNATGINYVLNISCSCP--------------------------------------------ALPGLENTGRYLRIPVK
| | .... . .. . |    .|   ||.......   .                                              .   .  .|...|. 
itpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywplgesltygdftvtllseehlddytvrtlevtnlgddesrevihyhylpwp

DTINENILDWFPTAFDFIDKVRE--VHGRVLLHCYAGKSRSATIAIGYIM-----KHLRLSLDEAYRFVKERRPTISPNLNFMGQLMQYEKDL
|    ..|...  ...|..|...   .|.|| || ||..|..|... |.|     |.|..||.||.......|| . ...... .|......|
dhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylmleqlekelgvsleeavkelrsqRpgavqtpsqyrflyeallel

0038934 (Phosphotyrosine protein) phosphatases II 196-293 2.7e-20 68.3 In-house 77-176 (194) alignment
Range on Protein: 196-293
Range on HMM: 77-176/194.0
ENTGRYLRIPVKDTIN----ENILDWFPTAFDFIDKvrEVHGRVLLHCYAGKSRSATIAIGYIMKHLRLSLDEAYRFVKERRPTISPNLNFMGQLMQYEK
..  .||..|..| ..    |..|...  . .|...    .| |. ||.||..|..|... |....|..|..||.....|.|| . || ... .|... |
kagieylklpfpddgtvPsleillrfldlvdeflne..dpggvvaVHCkaGlgRtGtlvaaYLiyrlgmsaeeAialfrekRpgaipnqdyleallkryk

DL
.|
el

0051429 (Phosphotyrosine protein) phosphatases II 158-299 3e-20 68.5 In-house 21-230 (272) alignment
Range on Protein: 158-299
Range on HMM: 21-230/272.0
PFLYLGTQE----HSLDEEFLNATGINYVLNISCSC-------PALPgleNTGRYLRIPVKDTINENILDWF----------------------------
| ... ..        | ..|   ||......   .       . ..      |||..|. |.  . || ..                            
pgrlyrsggplpltaadfwrlkelgiktivdLrseeErgrlkcdryw...pgirylhlpilddsaptilygalrvtllseellldyilrellltlllsag

--------------------PTAFDFIDKVREvHGRVLLHCYAGKSRSATIAIGYIMKhLRLS--------------LDEAYRFVKERRPTISPNLNFMG
                     .  .... ... .|.|| ||.|||.|..|..  ...  |..|              |.||.. ....|| . ..  .. 
earevmhlhytdwpdhgvpqeallellellld.ggpvlvHCsaGkdRTGtvvalllll.lgvsletivddYlltnlyleeaveelraqrpgavqteeqyl

QLMQYEKDLMITTTE
.|......|. . ..
flyeallellrslls

0036941 (Phosphotyrosine protein) phosphatases II 206-296 3e-20 68.2 In-house 175-279 (297) alignment
Range on Protein: 206-296
Range on HMM: 175-279/297.0
VKDTINENILDWFPTAFDFIDKVRE------VHGRVLLHCYAGKSRSATIAIGYIM--------KHLRLSLDEAYRFVKERRPTISPNLNFMGQLMQYEK
...    .. ... . .|||..||.       .|.|| || ||..||.|... ..|        |. .... ||.....|.|| . ..|... .| ... 
ytgwpdhgvpespaslldfielvrkvlkllpsggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeall

DLMIT
.|  .
ellkk

subfamily_PTPMT1_pd Subfamily PTPMT1 201-293 1.5e-19 65.1 In-house 76-168 (171) alignment
Range on Protein: 201-293
Range on HMM: 76-168/171.0
YLRIPVKDTINENILDWFPTAFDFIDKVREVHGRVLLHCYAGKSRSATIAIGYIMKHLRLSLDEAYRFVKERRPTISPNLNFMGQLMQYEKDL
.|.....|  ..  |.    . .||.||..   || .|| ||..||||... |.||. .||..|| ...|..|..|  . . . .| .||. |
qlqlatvDfteapdleklekgvefiekvaskgkrvYvHCkaGrgRsatlvacylmkkeklspeeAlkalkkkRkiirlakkqwkalqeyeekl

subfamily_Sponge-DSP-Subfam1_pd Subfamily Sponge-DSP-Subfam1 160-293 4e-19 62.1 In-house 6-141 (145) alignment
Range on Protein: 160-293
Range on HMM: 6-141/145.0
LYLGTQEHSLDEEFLNATGINYVLNISCSCpALPGLENTG---RYLRIPVKDTINENILDWFPTAFDFIDKVREVHGRVLLHCYAGKSRSATIAIGYIMK
|| |.  |. |   |.  ||  ..|.. .  ..   |  .     | |  .|    .. . |    ||||| .|    |..|| || ||| |... ..||
lyvgsalhandvptlqelgisrivnmaags.lvasqelksesieillitaedlesydlsqhfdevtdfidkgkeegagvfvhcmagvsrsvtvsvaflmk

HLRLSLDEAYRFVKERRPTISPNLNFMGQLMQYEKDL
.  ..| || | |. .|    ||..|. .|.. ||.|
ycnmtlseaarqvrsnrllaypnvtflknllnlekql

0039614 (Phosphotyrosine protein) phosphatases II 203-293 4.4e-19 64.5 In-house 190-288 (297) alignment
Range on Protein: 203-293
Range on HMM: 190-288/297.0
RIPVKDTINENILDWFPTAFDFIDKVRE---VHGRVLLHCYAGKSRSATIAIGYIM-----KHLRLSLDEAYRFVKERRPTISPNLNFMGQLMQYEKDL
 ..  |    ..|. .  ..........    .|.|| || ||..|..|... |.|     |. .....||.....|.|| . ...... .|......|
ytgwpdhgvppslellleflelvrealaelpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydallel

0043336 (Phosphotyrosine protein) phosphatases II 197-292 1e-16 56.7 In-house 176-275 (278) alignment
Range on Protein: 197-292
Range on HMM: 176-275/278.0
NTGRYLRIPvKDTINENILDWFPTAFDFIDKVREVHGRVLLHCYAGKSRSATIAIGYIM-----KHLRLSLDEAYRFVKERRPTISPNLNFMGQLMQYEK
.   || .|  ... |.. . .    .......  .| || || ||..|..|... |..     |.....|.||.....|.|| . ...... .| ....
thyhylgwp.dhgvpeslsllldflkavrealedsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflyeall

D
.
e

subfamily_MSG5_pd Subfamily MSG5 224-293 6.6e-16 51.9 In-house 91-160 (165) alignment
Range on Protein: 224-293
Range on HMM: 91-160/165.0
FIDKVREVHGRVLLHCYAGKSRSATIAIGYIMKHLRLSLDEAYRFVKERRPTISPNLNFMGQLMQYEKDL
 |   .  . ..|.||  | ||||.. . ||||.  ||| .||  .| .   |||.. .. |||..|  |
iihaatskrkkilvhcqcglsrsaslivayimkyynlslrdaydklksvaddispsiglifqlmeweval

0047943 (Phosphotyrosine protein) phosphatases II 211-288 1.5e-14 49.6 In-house 178-266 (273) alignment
Range on Protein: 211-288
Range on HMM: 178-266/273.0
NENILDWFPTAFDFIDKVRE------VHGRVLLHCYAGKSRSATIAIGYIM-----KHLRLSLDEAYRFVKERRPTISPNLNFMGQLMQ
. .. . .   ..||..||.       .| |. || ||..|..|... ...     |. .....||.......|| . ...... .|..
dhgvppslesllefielvrkalealpsngpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrflye

Rhodanese Rhodanese-like domain 17-121 6e-13 41.3 Pfam-A 9-111 (113) alignment
Range on Protein: 17-121
Range on HMM: 9-111/113.0
V--QSLLIIDSRSFLEYNDAHVINSINIGCSKLIKRRLITNKISIQELLKTGENVQPNQLgKVIVYDqdtqDMEGLSKDNFMSVVFSKLTS-SYKDVCFL
   ......| ||. ||.  |. ...|.  . | .||  . |  ..| |.. ..  ..   .|.||.     .   |.  . ...  .| . .||.|..|
lekekvvllDvRspeeyakghIpgAvnvpldslyprrdlffkdklaeeleesgkkldkdk.tvvvyc....rsgnrsggaaalllalilkelgyknvyvL

KGGFSFFA
.|||. ..
dGGfeawk

0051299 (Phosphotyrosine protein) phosphatases II 204-282 6.3e-13 44.3 In-house 58-274 (288) alignment
Range on Protein: 204-282
Range on HMM: 58-274/288.0
IPVKDT----------------------------------------------------------------------------------------------
|.  |                                                                                               
ilpydhsRVkLsvldgvegsdYinAsyidgynlkrkfIatqgPlpntvedFWrmvweqnvrvIvmltklvelgrekcaqYwplggsltygditvtllsee

-----------------------------------INENILDWFPTAFDFIDKVREV----HGRVLLHCYAGKSRSATIAIGYIM-----KHLRLSLDEA
                                    . .. | .   .||. .||..    .| |. || ||..|..|... ...     |. .... ||
vlddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpdspellldflrlvrkalasgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvlea

YRFVKERRPTISPNLNF
.....|.|| . .... 
vkrlreqRpgmvqtpeq

0050432 (Phosphotyrosine protein) phosphatases II 169-281 2.5e-12 42.2 In-house 44-286 (308) alignment
Range on Protein: 169-281
Range on HMM: 44-286/308.0
LDEEFLNATGINYvlNISCSCPALPGLENTGRYLRIPVKDT-----------INENILDW----------------------------------------
|.|||   . .    ....|. .||   .  ||  |.  |            || .  |                                         
leeefeellsvkp..lleysvallpenkdkNrykdilpydhsRVkldegsdYInAsyvdgyssklprkfIatqgPlpntvedFwrmvweqnvrvIvmLtk

--------------------------------------------------------------------------FPTAFDFIDKVREV--HGRVLLHCYA
                                                                          .   .||...||..  .| .. || |
lvengrekcaqYwplelgggsleygkftvtllseevlddytvrtleltnlgdgesrtvthfhytnWpdhgvPpspeilldflelvrkslpggpivVHCsa

GKSRSATIAIGYIM-----KHLRLSLDEAYRFVKERRPTISPNLN
| .|..|... ...     |. .... ||.....|.||   ....
GvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtpe

0046845 (Phosphotyrosine protein) phosphatases II 212-281 1.2e-11 40.0 In-house 178-261 (284) alignment
Range on Protein: 212-281
Range on HMM: 178-261/284.0
ENILDWFPTAFDFIDKVREV------HGRVLLHCYAGKSRSATIAIGYIMKHL--------RLSLDEAYRFVKERRPTISPNLN
 .. . .   ..|...|||.      .| .. || ||..|..|... ......        .... ||.....|.||    .| 
hgvppspedlleflrlvrellenlpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtle

0048567 (Phosphotyrosine protein) phosphatases II 217-280 8e-09 30.1 In-house 59-125 (157) alignment
Range on Protein: 217-280
Range on HMM: 59-125/157.0
WFPTAFDFIDKVREVHGRVLLHCYAGK---SRSATIAIGYIMKHLRLSLDEAYRFVKERRPTISPNL
..  . .|.. ... .... .||.||    .|.||..  |...||... .||.....  ||.. |  
FilklnkflkilelagkaiavhckaglkkrgrtatLigcYlilhlgftpeeaiaplrivrpgsvpfr

subfamily_Laforin_pd Subfamily Laforin 200-276 3.3e-08 26.6 In-house 78-154 (183) alignment
Range on Protein: 200-276
Range on HMM: 78-154/183.0
RYLRIPVKDTINENILDWFPTAFDFIDKVREVHGRVLLHCYAGKSRSATIAIGYIMKHLRLSLDEAYRFVKERRPTI
 |. .|..|   |. .. .| |  ..  . |   .| .|| ||  ||..|  |...  |  ||     |.  .||..
ayiwlptedlstesrvenlpqavyllhallekghivyvhcnagvgrstaivcgflqyvlgwslakvqyfllakrpvv

subfamily_CDC14_pd Subfamily CDC14 224-279 2.2e-07 25.1 In-house 255-312 (328) alignment
Range on Protein: 224-279
Range on HMM: 255-312/328.0
FIDKVREVHGRVLLHCYAGKSRSATIAIGYIMKHLRLSLDEAYRFVKERRPT--ISPN
|.. . ...| . .|| ||  |  |.   |.||| |..  ||  ...  ||   |.| 
fleiaekaeGaiavhCkaGLGrtGtLiacylmkhyrftaaeaiawlricrPGsvigpq

subfamily_PTPDC1_pd Subfamily PTPDC1 232-276 4.2e-07 24.6 In-house 114-158 (182) alignment
Range on Protein: 232-276
Range on HMM: 114-158/182.0
HGRVLLHCYAGKSRSATIAIGYIMKHLRLSLDEAYRFVKERRPTI
.|.| .||.||. |   .   |.. . ||. ..| ..|...||  
egkvavhChaGlGrtGvliacylvyakrltaekaiklvrskrpks

subfamily_DSP23_pd Subfamily DSP23 172-276 4.8e-06 21.3 In-house 25-128 (148) alignment
Range on Protein: 172-276
Range on HMM: 25-128/148.0
EFLNATGINYVLNISCSCPALPGLENTGRYLRIPVKDTInENILDWFPTAFDFIDKVREVHGRVLLHCYAGKSRSATIAIGYIMKHLRLSLDEAYRFVKE
..|   |. |.. ..  ..       .  . |. ..|      |.        ...  |    | .||  |. |. |.   |..|. .|.  ||   |..
rylldlgvrylvslteegrphveatpnltlvrlriddyh.ppaleqvvefvrvveeaeekneavsvhcllgrgrtgtmlacylvkerklaaaeaiaevrr

RRPTI
.||  
lrpgs