Gene NvecDSP-Un-1 in Nematostella vectensis

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family DSP
Subfamily DSP-unclassified
Protein sequence
ID Type Fasta BLAST phosphatome Note
NvecP015_AA protein Get Run
NvecP015_AA_334-479 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_MKPLT_pd Subfamily MKPLT 317-480 3.7e-93 303.5 In-house 1-164 (164) alignment 
Range on Protein: 317-480
Range on HMM: 1-164/164.0
FLCTDKQFYQLEDYKRIQIYPSIILPKQLYLGKGDQATNKKIMEDLKITHIVNITQEHKSAFPESIEYLTLQLDDVPQTQLINFFEKTTKFLSDAIDGGG
||.||......||||||.||||..|...||||....|||.|...|||||||||..||.|.|||.|.|||.....|....||..|.|...|||.||||.||
fLitdldvrdeeDykrikiypsvvledtlylGnakhatnekvlkdlkithivnvsqekkdafpksveYlqvkvedesdeqlssfleraakfladaidsGG

CVMVHCNMGVSRSSSVTLAYLIKSKRWTLGEAYSFIKERRSCVRPNRGFLKQLATWEEMILGKR
.|.|||..|.|||||||.|.|||||.|||.|||...|||||.|.||||||||||..||.||||.
rvlvhcvqGksrsssvtvafLikskgwtlkeayeylkerrsivapnrGflkqlakfeelilGkv
subfamily_MKPLV_pd Subfamily MKPLV 317-480 3.7e-93 303.5 In-house 1-164 (164) alignment 
Range on Protein: 317-480
Range on HMM: 1-164/164.0
FLCTDKQFYQLEDYKRIQIYPSIILPKQLYLGKGDQATNKKIMEDLKITHIVNITQEHKSAFPESIEYLTLQLDDVPQTQLINFFEKTTKFLSDAIDGGG
||.||......||||||.||||..|...||||....|||.|...|||||||||..||.|.|||.|.|||.....|....||..|.|...|||.||||.||
fLitdldvrdeeDykrikiypsvvledtlylGnakhatnekvlkdlkithivnvsqekkdafpksveYlqvkvedesdeqlssfleraakfladaidsGG

CVMVHCNMGVSRSSSVTLAYLIKSKRWTLGEAYSFIKERRSCVRPNRGFLKQLATWEEMILGKR
.|.|||..|.|||||||.|.|||||.|||.|||...|||||.|.||||||||||..||.||||.
rvlvhcvqGksrsssvtvafLikskgwtlkeayeylkerrsivapnrGflkqlakfeelilGkv
subfamily_DSP1_pd Subfamily DSP1 330-477 1.7e-45 149.0 In-house 9-157 (163) alignment 
Range on Protein: 330-477
Range on HMM: 9-157/163.0
YKRIQIY-PSIILPKQLYLGKGDQATNKKIMEDLKITHIVNITQEHKSAFPESIEYLTLQLDDVPQTQLINFFEKTTKFLSDAIDGGGCVMVHCNMGVSR
 .....| |. ..   ||||   .|.|..|...|.||.|.|...| . .|..  || .|.|.| |. ..   ||.  .|. .... .| |..||..|.||
ldklklydPvekildfLylGsetvasnleiLkslgitailnvskeldnvfedlfeYkklkleDspkadislvfeeviefidevkkknGkvlihCqaGisR

SSSVTLAYLIKSKRWTLGEAYSFIKERRSCVRPNRGFLKQLATWEEMIL
||.. ||||.|.||..| ||. |.|.|||...|| || .|| ..|. .|
sstlclaylmktkrvsleeafdfvkqrRsiisPnagFvlqLlnyekkll
subfamily_DSP19_pd Subfamily DSP19 342-476 5.1e-44 144.3 In-house 16-150 (152) alignment 
Range on Protein: 342-476
Range on HMM: 16-150/152.0
PKQLYLGKGDQATNKKIMEDLKITHIVNITQEHKSAFPESIEYLTLQLDDVPQTQLINFFEKTTKFLSDAIDGGGCVMVHCNMGVSRSSSVTLAYLIKSK
 ..||||  | |..|.|..  |||||.|.. . . .||. ..||.... |.|.|.|.........|. .| .  |.|.|||| |||||.|| .|||.|..
eprlylgsqdvaadkeilkekkitHilnvatgvpnvfpkdftylsieilDlpetdllsylkealdFieearskdgavlvHCnAGvSRsasvviaylmkke

RWTLGEAYSFIKERRSCVRPNRGFLKQLATWEEMI
. .| ||.. ..| | |..|| ||.||| ..|. .
elsleealelvrearpcikPneGFikqLkeyeael
subfamily_DSP14_pd Subfamily DSP14 343-479 5.9e-42 137.3 In-house 12-147 (157) alignment 
Range on Protein: 343-479
Range on HMM: 12-147/157.0
KQLYLGkGDQATNKKIMEDLKITHIVNITQEHKSAFPESIEYLTLQLDDVPQTQLINFFEKTTKFLSDAIDGGGCVMVHCNMGVSRSSSVTLAYLIKSKR
..|.|. |  |..|. ..  |||.|.|.|.| ..   ..||.. ....| |...| ..|..... . ..   ||...||| .||||| |..||||.| ..
psLfls.gvaalskellkkkkitliinvtvelpntklkdiervkvpveDnpeaklakhfdevadkieevkkkggktlvhCvaGvSRSAslclaylmkyek

WTLGEAYSFIKERRSCVRPNRGFLKQLATWEEMILGK
 .| |||. .|..|. .||| || ||| ..|. . ||
lsLreayklvksaRpiirPNvGFwkqlidyEkklkgk
subfamily_STYXL1_pd Subfamily STYXL1 331-479 2.6e-40 131.2 In-house 5-156 (157) alignment 
Range on Protein: 331-479
Range on HMM: 5-156/157.0
KRIQIYPSIILPKQLYLGKGDQATNKKIMEDLKITHIVNITQE---HKSAFPESIEYLTLQLDDVPQTQLINFFEKTTKFLSDAIDGGGCVMVHCNMGVS
 ... ||. .||..||||.  ||.|..| .|||.   ||....     .. ..  . |.....|.....|......  .|. .    | .|.|  | |.|
delktyPvevlPgklylGnykqaqnpaikkdlkvkahvnvsmdadkliagvadvakllhiavedeneadllerlkeavqfiekhkkegevvlvfsnkGis

RSSSVTLAYLIKSKRWTLGEAYSFIKERRSCVRPNRGFLKQLATWEEMILGK
|| .| .|||. ||..|| .||...|. .. |.|||.|..||  ||...||.
rsaaviiaylmyskkitlkkaykylkkCkenvkPnrafveqlseWekqllge
subfamily_Choan-DSP_MKP-1_pd Subfamily Choan-DSP_MKP-1 333-474 4e-40 130.7 In-house 3-145 (148) alignment 
Range on Protein: 333-474
Range on HMM: 3-145/148.0
IQIYPSIILPKQLYLGKGDQATNKKIMEDLKITHIVNITQEHKSAFPE-SIEYLTLQLDDVPQTQLINFFEKTTKFLSDAIDGGGCVMVHCNMGVSRSSS
.. .|| | .  |.||   .|.. . ...| .|.||| |.|.. |. . .|||| ..||| |. .|  .||. ..|.. | | |. |.||..||||||| 
LrtfpseikdafLFlGskksaadlealkalgvtrivnatkerdnaldqrgieYlhvaldDkpkedlsaiFediiafvrkakdeGrrvLvhlqmGvsrssa

VTLAYLIKSKRWTLGEAYSFIKERRSCVRPNRGFLKQLATWEE
..|..||. || .| ||. ..|..|  |.|| ||||||| .|.
lallwlidfkrvslkealalvkskrryvdpnlgfLkqLaeleq
subfamily_Slingshot_pd Subfamily Slingshot 343-480 1.7e-39 128.9 In-house 24-161 (169) alignment 
Range on Protein: 343-480
Range on HMM: 24-161/169.0
KQLYLGKGDQATNKKIMEDLKITHIVNITQEHKSAFPESIEYLTLQLDDVPQTQLINFFEKTTKFLSDAIDGGGCVMVHCNMGVSRSSSVTLAYLIKSKR
. .|||    |.| . ... ....|.|.|.| .. |||..|||.... | ..|.|......| ||.. | . |  |.||| ||||||.|. .|| .|. .
dhvylGsewnasnleelkengveyilnvtkeidnffpekfeylnirvydeeetdllkywnetykfiekakkkgskvlvhckmGvsrsastviayamkeyg

WTLGEAYSFIKERRSCVRPNRGFLKQLATWEEMILGKR
..| ||....|||||...||.|||||| ..| ..  ..
lsleealeyvkerrsvikPnkgflkqleeyeGileask
PTPc_motif_SM00404 337-475 4.1e-39 128.6 In-house 2-140 (140) alignment 
Range on Protein: 337-475
Range on HMM: 2-140/140.0
PSIILPKqLYLGKGDQATNKKIMEDLKITHIVNITQEHKS-AFPESIEYLTLQLDDVPQTQLINFFEKTTKFLSDAIDGGGCVMVHCNMGVSRSSSVTLA
|| |||. ||||. ..|.|..... |.|||..|.|.| .     .....| ..|||  ...| ....|...|...|.. || |.||| .||||| ....|
psrilph.lylgskskaqnpallkklgithvinvteevsltkensgfqilqiplddnekdklskyldkvldfienaekkggkvlVHCqaGvSRSatliia

YLIKSKRWTLGEAYSFIKERRSCVRPNRGFLKQLATWEEM
||.... ..| |||.|.||||....|| .|..||  .|..
YlmryrqlslaeayefvkerRpiispnlnfvrqLieyekk
subfamily_DSP12_pd Subfamily DSP12 343-477 5e-38 124.9 In-house 7-144 (155) alignment 
Range on Protein: 343-477
Range on HMM: 7-144/155.0
KQLYLGKGDQATNKKIMEDLKITHIVNITQEH---KSAFPESIEYLTLQLDDVPQTQLINFFEKTTKFLSDAIDGGGCVMVHCNMGVSRSSSVTLAYLIK
..||||.  ...... ...|||||.. ...|.    .. .  ......|..| |.. ..........|...|.. .| |.|||..|||||... .|||.|
pglylggleavqeeellkelkithvlsvikeelpehklkkgkvstkfiqilDepeediLshldeavdFieealeeegavlvHCqagvSRSvtiviAYlmk

SKRWTLGEAYSFIKERRSCVRPNRGFLKQLATWEEMIL
.... | .|....|| .. ..|| |||.||  .|.|  
keklslekAlklvkekkpeiepNegFleQLklfekmgc
DSPc Dual specificity phosphatase, catalytic domain 345-474 2.9e-36 119.2 Pfam-A 1-132 (133) alignment 
Range on Protein: 345-474
Range on HMM: 1-132/133.0
LYLGKGDQATnKKIMEDLKITHIVNITQEHKS---AFPESIEYLTLQLDDVPQTQLINFFEKTTKFLSDAIDGGGCVMVHCNMGVSRSSSVTLAYLIKSK
||||.  .|. ....|.|.||...|.|.| .      ...|||| ....|  .|.. ...|....|...|.. |. |.|||..|.||| ....|||.|.|
lylgskstas.lalleklgitlvinvtkevpnnnaikkseieylripvedetetkiskeleeavefiekaeqkgkkvlVHCqaGisRSatliiaYlmktk

RWTLGEAYSFIKERRSCVRPNRGFLKQLATWEE
...| |||.|.|||||...|| |||.||  .|.
nlslneAyefvkerrskispnagflrqLleyer
DSPc Dual specificity phosphatase, catalytic domain 345-474 2.9e-36 119.2 In-house 1-132 (133) alignment 
Range on Protein: 345-474
Range on HMM: 1-132/133.0
LYLGKGDQATnKKIMEDLKITHIVNITQEHKS---AFPESIEYLTLQLDDVPQTQLINFFEKTTKFLSDAIDGGGCVMVHCNMGVSRSSSVTLAYLIKSK
||||.  .|. ....|.|.||...|.|.| .      ...|||| ....|  .|.. ...|....|...|.. |. |.|||..|.||| ....|||.|.|
lylgskstas.lalleklgitlvinvtkevpnnnaikkseieylripvedetetkiskeleeavefiekaeqkgkkvlVHCqaGisRSatliiaYlmktk

RWTLGEAYSFIKERRSCVRPNRGFLKQLATWEE
...| |||.|.|||||...|| |||.||  .|.
nlslneAyefvkerrskispnagflrqLleyer
0044763 (Phosphotyrosine protein) phosphatases II 334-479 5e-36 119.4 In-house 20-173 (178) alignment 
Range on Protein: 334-479
Range on HMM: 20-173/178.0
QIYPSIILPKqLYLGKGDQATNKKIMEDLKITHIVNITQEHKSAFPES---------IEYLTLQLDDVPQTQLINFFEKTTKFLSDAI-DGGGCVMVHCN
.|..| |||  ||||   .| ... . .|.||||||.|.|    |...         |.|| . ..| . ..|. .|.....|. .|. . ||.| |||.
yinaseilpg.lylgslppaddlellkelgithivnlteelelgflkcdpywpeeagiqylhipipDhgvpdllehflefvefieealdekggpvlVHCs

MGVSRSSSVTLAYLIKSKRWTLGEAYSFIKERRScVRPNRGFLKQLATWEEMILGK
.||.|| .. .|||.|. ...| ||.....|||. . ||.|.|.||  .|...|..
aGvgRsgtlvaaylmkklglsleeaielvrerRp.ivpnpgqlrqLyefelrllke
subfamily_DSP6_pd Subfamily DSP6 334-476 1.9e-35 115.7 In-house 11-154 (158) alignment 
Range on Protein: 334-476
Range on HMM: 11-154/158.0
QIYPSIILPkQLYLGKGDQATNKKIMEDLKITHIVNITQEHKSAFPE--SIEYLTLQLDDVPQTQLINFFEKTTKFLSDAIDGGGCVMVHCNMGVSRSSS
. .|  ||| .||||  ..|.| .....||| ...|.|..  ..| |  ...|| . ..|. ...| .|| .. .|. .|      |.|||  |.|||  
aefpveilp.llylGsakdasnlevlkklkikyvlnvtsnlpnkfeesgelkylqipiedhlsqnlakffPeaiefidearskkskvlvhClaGisrsvt

VTLAYLIKSKRWTLGEAYSFIKERRSCVRPNRGFLKQLATWEEMI
||||||.|..  .| .|| ..|.|.| . ||  |..||  .|...
vtlaylmkklalslndaydlvkkrksnisPnfnfmgqlldfersl
subfamily_LRR-DSP_pd Subfamily LRR-DSP 333-475 8.4e-35 114.1 In-house 116-257 (263) alignment 
Range on Protein: 333-475
Range on HMM: 116-257/263.0
IQIYPSIILPKqLYLGKGDQATNKKIMEDLKITHIVNITQEHKSAFPESIEYLTL-QLDDVPQTQLINFFEKTTKFLSDAIDGGGcVMVHCNMGVSRSSS
  . |. |..| |.||  | |.|| |..|| .|||.    . .  ||.   ||.. ...||.. .. ..||.|  |. .  . || |.|||  ||||||.
vssvPdeiidk.lflGgldsannksilkdlgvthillavadfePlfPklfkylsiddiedvdeadisqhfeetnafieeGrkkGG.vlvhcraGvsrsst

VTLAYLIKSKRWTLGEAYSFIKERRSCVRPNRGFLKQLATWEEM
....||.| .| .. ||. .....|. ..||.||..||  .|. 
lvisylmkkqrlkfkealdlvikkrpriqPnpGfkdqlkkyekk
subfamily_DSP10_pd Subfamily DSP10 337-475 4.3e-34 111.7 In-house 14-152 (159) alignment 
Range on Protein: 337-475
Range on HMM: 14-152/159.0
PSIILPkQLYLGKGDQATNKKIMEDLKITHIVNITQEHKSAFPE-SIEYLTLQLDDVPQTQLINFFEKTTKFLSDAIDGGGCVMVHCNMGVSRSSSVTLA
 | .||  |.||.. .|....... |.||...|.|..    | | ...|  ... |  . .| . ||.  .|. .|   |  |.|||. |.|||..|..|
asqvlp.fLflGsekdaadldaldrlnitavlnvttsvPnefeeealkYkripvsDtskqnlkqyfeealefieearkkgsrvLvhCqaGisrsatvvia

YLIKSKRWTLGEAYSFIKERRSCVRPNRGFLKQLATWEEM
||.| .. .| .|| |.||.|. . || .|. ||  .|. 
YlmkhlnlslndaykfvkekrpiisPnLnfmGqLlefeke
0048076 (Phosphotyrosine protein) phosphatases II 336-476 4.2e-32 106.2 In-house 3-142 (145) alignment 
Range on Protein: 336-476
Range on HMM: 3-142/145.0
YPSIILPKqLYLGKGDQATNKKIMEDLKITHIVNITQEHKSAFPESIEYLTLQLDDVPQTQLINFFEKTTKFLSDAIDGGGCVMVHCNMGVSRSSSVTLA
.|| |||. ||||    | . . ..||.||...|.| | .  ... |.|| | ..| .  .|......  .|. .|.. ||.| |||..||.|. .. .|
wpseilpg.lylgslptaldlellkdlgittvlnltselellerlgiqylylpwpDhgvpdllellleflefieealkeggpvlVHCsaGvgRtgtlvaa

YLIKSKRWTLGEAYSFIKERRSCVRPNRGFLKQLATWEEMI
||.......| ||. .....|... || |.|..|  .|...
ylmlllgvsleealelvrsqrpgavpnpgqlrflyefelel
subfamily_DSP3_pd Subfamily DSP3 344-475 7e-32 104.3 In-house 17-156 (162) alignment 
Range on Protein: 344-475
Range on HMM: 17-156/162.0
QLYLGKGDQATNKKIMEDLKITHIVNITQEH-------KSAFP-ESIEYLTLQLDDVPQTQLINFFEKTTKFLSDAIDG-GGCVMVHCNMGVSRSSSVTL
.||.|. . |..|. .. | |||..| .. .       .. .   .|.|| |..||||...| ..||...||. .|..   | |.|||..|||||. . |
klyvgdeavakdkskLkklGithvlnaaegrfskvdtgaefykdleikylGlevdDvpefdlskyFetaakfidealsqkegkvlvhcvvGvsRsatlvl

AYLIKSKRWTLGEAYSFIKERRsCVRPNRGFLKQLATWEEM
|||. ... || || . ....| ...||.|||||||. .| 
ayLmirrkmtlveairtvrkkR.eilPneGFlkqLaeldee
subfamily_DSP15_pd Subfamily DSP15 343-476 9.4e-31 100.9 In-house 7-139 (151) alignment 
Range on Protein: 343-476
Range on HMM: 7-139/151.0
KQLYLGKGDQATNKKIMEDLKITHIVNITQEHKSAFPEsIEYLTLQLDDVPQTQLINFFEKTTKFLSDAIDGGGCVMVHCNMGVSRSSSVTLAYLIKSKR
. ||||   .. ... ... .||||... .. |  ... |||......| |...| .||... .|. ..   .. |.||| .|||||  .. |||.    
pglylgnfrdskdeelLkeknithilsvhdnakkllkd.ieYkciaasDtpsaklskffkesvefihkcRlkeenvlvhClaGvsRsvtlvvaYlmtvte

WTLGEAYSFIKERRSCVRPNRGFLKQLATWEEMI
    .| ..||..||.  || || .||  .|.. 
lnwrdalevikaaRsvanPnfGfkrqlkeyektk
0048179 (Phosphotyrosine protein) phosphatases II 337-475 1.2e-30 101.5 In-house 4-143 (144) alignment 
Range on Protein: 337-475
Range on HMM: 4-143/144.0
PSIILPKqLYLGKGDQATNKKIMEDLKITHIVNITQEHKSAFPESI--EYLTLQLDDVPQTQLINFFEKTTKFLSDAIDGGGCVMVHCNMGVSRSSSVTL
|| |||. ||||    | . . . .|.||...|.| |.  .|.|    .|| | ..| .  .|....... .|. .|.. ||.| |||..||.|. .. .
pseilpg.lylgslptaldlellkklgittvinlteeyepefleregiqylhlpwpDhgvpdllellleflefieealeeggpvlVHCsaGvgRtgtlva

AYLIKSKRWTLGEAYSFIKERRSCVRPNRGFLKQLATWEEM
|||.| ....| ||. ....||... ||.|.|..|  .|..
aylmkklglsleealalvrsrrpgavpnpgqlrfLleyekl
subfamily_Dicty-DSP19-like_pd Subfamily Dicty-DSP19-like 344-474 8e-30 97.2 In-house 9-150 (154) alignment 
Range on Protein: 344-474
Range on HMM: 9-150/154.0
QLYLGKGDQATNKKIMEDLKITHIVNITQEHKSAFPES---------IEYLTLQLDDVPQTQLINFFEKTTKFLSDAIDG--GGCVMVHCNMGVSRSSSV
 ||..  | | ||  ..  .|..|.|.    . .|..          |||| |.| | .. ..|. ..|. .|. ||| |   . |.||.. |||||...
flyissfdaalnkldlqlkniksilnvgiGinnlftdensdindgfiieylnlelfddvnfdiiekldkafefiddaiggvennkvlvhsdkGvsrsaal

TLAYLIKSKRWTLGEAYSFIKERRSCVRPNRGFLKQLATWEE
 ..||..... .| .|. ..|. |  ..||.||||||  .| 
lisylmdklkislslalellkdsryiikPnqGflkqleifek
0043147 (Phosphotyrosine protein) phosphatases II 345-476 3.3e-28 94.0 In-house 26-160 (172) alignment 
Range on Protein: 345-476
Range on HMM: 26-160/172.0
LYLGKGDQATNKKIMEDLKITHIVNITQE---HKSAFPESIEYLTLQLDDVPQTqLINFFEKTTKFLSD--AIDGGGCVMVHCNMGVSRSSSVTLAYLIK
....  . | . . . .|.||||||.|..    .  ... |.|| |  .| . . |....... .|. .  |.. ||.| ||| .||.|.  . .|||..
qgplrntladfwrmlkelgithivnltellydpellerlgiqylylpwpDhgvp.llellleflefidellalspggpvlVHCsaGvgRtgtlvaaylml

sKRWTLGEAYSFIKERRSCVRPNRGFLKQLATWEEMI
 ....| ||.....|.|... .| .....|  .|...
.lglsleeavalvrekRpgavqnpsqyrflyyfekll
0041856 (Phosphotyrosine protein) phosphatases II 332-479 7e-28 92.8 In-house 17-175 (182) alignment 
Range on Protein: 332-479
Range on HMM: 17-175/182.0
RiqiYPSIILPKqLYLGKGDQ--------------ATNKKIMEDLKITHIVNITqeHKSAFPES-----IEYLTLQLDDVPQTQlinfFEKTTKFLSDAI
|   ... |... ||||   .              | . . . .|.||.|||.|      .||      |.|| |. .| . .     .... .|. ...
r...dldyInan.lylgslpatrfiatqgpllstvadflrmlkelgittivnlt..eelywpellerlgiqylylpwpDhgvpd....ldelldfieevl

DGGGCVMVHCNMGVSRSSSVTLAYLIKSKRWTLGEAYSFIKERRS--CVRPNRGFLKQLATWEEMILGK
. ||.| |||..||.|. .. .|||.|.....| ||......||.  ...|| .|. ||| .|.. |.|
eeggpvlVHCsaGvgRtgtlvaaylmkklgvsleeavklvrsrRpgmvitpnqyfflqlallellllkk
0049772 (Phosphotyrosine protein) phosphatases II 360-476 1.1e-27 93.1 In-house 167-273 (314) alignment 
Range on Protein: 360-476
Range on HMM: 167-273/314.0
EdlkithivnitQEH--KSAFPES-IEYLTLQLDDvPQTQLINFFEKTTKFLSDAiDGGGCVMVHCNMGVSRSSS-VTLAYLIKSKRWTLGEAYSFIKER
.           .|.  .. |..  |.|| . ..| ... |...|..  .|. .| | ||.| |||..|..|. . |..|||.|  ...| ||.......
k...........eelydpelferlgikylripvpD.gsaplledfdeflefieea.dkggpvlvHCkaGkgRtgtfvvaaylmkllgvsleealedvrlk

RScVRPNRGFLKQLATWEEMI
|. ..||.||..||  .|.. 
Rp.inpnpgfieqleqyefil
subfamily_STYX_pd Subfamily STYX 340-479 3.4e-27 88.6 In-house 15-160 (166) alignment 
Range on Protein: 340-479
Range on HMM: 15-160/166.0
ILPkQLYLGKGDQATNKKI--MEDLKITHIVNITQEH-----KSAFPESIEYLTLQLDDVPQTQLINFFEKTTKFLSDAIDGGGCVMVHCNMGVSRSSSV
|||  |.||    | . |.  ...  ||||| | |.      |  ||... || |.. | .  ..| .. .. .|. |... || |.|| | |.|||...
ilp.glflgpysaamksklevlkkhgithivcirqnieanlikpnfpdrfrylvldvadntveniirylptvkefiddslqkggkvlvhgnagisrsaal

TLAYLIKSKRWTLGEAYSFIKERRSCVRPNRGFLKQLATWEEMILGK
 .||....      ||. ...||| |. || || .||  .| . | |
viayimetyglkyreafayvqerrfcinpnegfvsqlkeyeaiylak
subfamily_DSP8_pd Subfamily DSP8 337-476 3.5e-27 88.9 In-house 15-154 (159) alignment 
Range on Protein: 337-476
Range on HMM: 15-154/159.0
PSIILpKQLYLGKGDQATNKKIMEDLKITHIVNITQ-EHKSAFPESIEYLTLQLDDVPQTQLINFFEKTTKFLSDAIDGGGCVMVHCNMGVSRSSSVTLA
|  || |.||||   .. .......| |....|. .   |. . .  ..| . . |  . .|...|.|...|.  |    |.|.||.  | |||..| .|
ptril.knlylGsqkdvlseellsklgisyvlnasnscpkleelkeskflrvPvkDkydekllpwfdksvefidkaksengrvlvhvlaGisrsatvaia

YLIKSKRWTLGEAYSFIKERRSCVRPNRGFLKQLATWEEMI
|..|  . .| ||| |.||.|  . ||  ||.||  .|. .
yimktlemsldeayrfvkekrptispnlnflgqLleyekel
0037934 (Phosphotyrosine protein) phosphatases II 317-473 2.9e-25 84.7 In-house 19-238 (243) alignment 
Range on Protein: 317-473
Range on HMM: 19-238/243.0
FLCTDKQFYQLEDYKRIQIYPSIILPKqLYLGKG--------DQATNKKIMEDLKITHIVNITQEH----------------------------------
.|. |  .  ||.   |    . ..|. |... |        | |.. . . .|.||.||..|..                                   
ilpydhsrvklegsdyinanliyvtpr.liatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywpgevtygdftvtllseehlddyt

-----------KSAFPESIEYLTLQLDD----VPQTQLINFFEKTTKFLSD-----AIDGGGCVMVHCNMGVSRSSSVTLAYLIKSK-RWTLGEAYSFIK
           .  . . | |. |   |       ..|..|......|...     |.|.|| | ||| .||.|.  . .|||.... ...| ||. ...
vrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRtGtliaaylmllllgvdleeavkllr

ERRSC-VRPNRGFLKQLATWE
|.|.. . ........|  ..
eqRpgkavqtpsqyrflyeal
0045098 (Phosphotyrosine protein) phosphatases II 330-477 1.9e-24 82.0 In-house 15-272 (278) alignment 
Range on Protein: 330-477
Range on HMM: 15-272/278.0
YKRIQIYPSIILPkQLYLGKGD-----------------------------------------QATNKKIMEDLKITHIVNIT-----------------
..... .|| |.|  |||| .|                                          | . . . .|.||.||..|                 
fllllgipseitp.alylgnldknRykdilpydhsrVkdYINAsyidgypkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrekcaqywpeg

-----------------------------------QEHKSAFPESIEYLTLQLDDVPQTQLINFFEKTTKFLSDAID--------------GGGCVMVHC
                                   .. .|.. . . ||.    .|| . ....| . ..|. .|..              .||.| |||
gsltygdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsggpvlVHC

NMGVSRSSSVTLAYLIKSK---RWTLGEAYSFIKERRSC-VRPNRGFLKQLATWEEMIL
..||.|.  . .|||...    ...| ||.......| . . .| .....|  .. ..|
saGvgRtGtlvaaylmlelleggvdlleavkelrsqRpglavqnleqyrflyefllell
0049260 (Phosphotyrosine protein) phosphatases II 345-474 1.9e-24 81.5 In-house 15-147 (152) alignment 
Range on Protein: 345-474
Range on HMM: 15-147/152.0
LYLGKGDQATNKKIMEDLKITHIVNITQEHKS---AFPESIEYLTLQLDDVPQTQLINFFEKTTKFLSD-AIDGGGCVMVHCNMGVSRSSSVTLAYLIKs
...|  . | ... . .|.||.||..|...      ... |.|| |. .| .  .|. ...   .|.   |.| ||.| |||  ||.|.  . .|||.. 
qgpgpntladfwrmlkelgittivmltellelgklkceqyiqylhlpwpDhgvpdlsqlllflllfieklaldkggpvlVHCsaGvgRtgtlvaaylml.

KRWTLGEAYSFIKERRSCVRPNRGFLKQLATWEE
....| ||.....|.|... || |.|..|  .|.
lgvsleeavalvrekRpgavpnpgqlrflyefek
PTEN_1 341-476 7.3e-24 79.7 In-house 44-191 (196) alignment 
Range on Protein: 341-476
Range on HMM: 44-191/196.0
LPKQLYLGKGDQA-TNKKIMEDLKITHIVNITQEH---------KSAFPESIEYLTLQLDDVPQTQLINFFEKTTKFLSDAI--DGGGCVMVHCNMGVSR
....||.|  ...  ... ..  .||..|| . |          ...| . .||| .  .| .   |  .|.   .| . ..  . |..|.|||  |..|
ideglyrgslkdvaadldnlkedgitlvvnlseeeelsgrsydleeffksgveylhfpieDhgapslselfdicksfiewllsdpngnvVlVHCkaGlgR

SSSVTLAYLIKSKRWTLGEAYSFIKERRSCVRPNRGFLKQLATWEEMI
|  |  |||......|  || ....|.|....|| .....|   ....
sGtvvaayLmykgkltadeAlelvrekRppgapnspsqerlleyfael
0046846 (Phosphotyrosine protein) phosphatases II 335-477 1.1e-23 79.4 In-house 15-173 (176) alignment 
Range on Protein: 335-477
Range on HMM: 15-173/176.0
IYPSIILPKQLYLGKG----DQATNKKIMEDLKITHIVNITQEH-----------KSAFPESIEYLTLQLDDVPQTQLiNFFEKTTKFLSDAIDGGGCVM
|....||    . . |    . |.. . . .|.||..||.|.|.           .    ..|.|| |  .|    .| . ...  .|. .|.. ||.| 
inanlilgsrpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgiqylhlpwpDhgvpdl.elllellefirealkeggpvl

VHCNMGVSRSSSVTLAYLIKS-KRWTLGEAYSFIKERRS-CVRPNRGFLKQLATWEEMIL
||| .|..|.  . .|||... | ... ||.....|.|. .. ........|  .| ..|
VHCsaGigRtgtlvaayllelekglsveealalvreqRplgavqtpeQyrflyefellll
0040439 (Phosphotyrosine protein) phosphatases II 352-475 1.2e-23 79.5 In-house 67-244 (249) alignment 
Range on Protein: 352-475
Range on HMM: 67-244/249.0
QATNKKIMEDLKITHIVNITQEHKS-------------------------------------------AFPESIEYLTLQLDDVPQTQLINFFEKTTKFL
 . . . . .|.||.||..|..                                               ..||...| .|  | | ...  .|| . .|.
vedfwrmlwelgitvivmLtslvelgrekcaqywplggsleygdftvtllsvevkddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldfi

SDAID------GGGCVMVHCNMGVSRSSSVTLAYLI-----KSKRWTLGEAYSFIKERRSCVRPNRGFLKQLATWEEM
  . .       ||.|.|||..||.|.  . .|||.     | ....| ||.......|... .| .....|  .. .
eavrkaleelpkggpvlVHCsaGvgRtGtfiaaylmleqlekelgvdleeavkllrsqRpgavqnpeqyrflyealle
0045450 (Phosphotyrosine protein) phosphatases II 327-473 1e-22 76.7 In-house 52-300 (307) alignment 
Range on Protein: 327-473
Range on HMM: 52-300/307.0
LEDYKRIQIYP---------------------------SIILPKQLYLGKGDQATNKKI----------------MEDLKITHIVNITQEHKSAF-----
|.  |    |.                           | . .  |.|..|   ..| |                . ....|.||..|..   ..     
lpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydlkrkfIatqgPlpetvedFwrmlweqgvtvivmltelvelgrekcaq

-----------------------PESIEYLTLQLDDV-----------------PQTQLINFFEKTTKFLSDAID------GGGCVMVHCNMGVSRSSSV
                        ... ..|| . |                  | ...  .|| . .|.  . .      .||.|.|||..||.|. ..
ywPdegeeltygnftvtllseehldgytvrtlevtdldgtgesrtvthfhytgwpdhgvppsfeelldfieevrkaleelpkggpvlVHCsaGvgRtGtf

TLAYLIKSKR--------WTLGEAYSFIKERRSCVRPNRGFLKQLATWE
 .|||... .        ..| ||.....|.|... .| .....|  ..
iaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyeal
0036282 (Phosphotyrosine protein) phosphatases II 329-475 3.4e-22 74.4 In-house 3-168 (174) alignment 
Range on Protein: 329-475
Range on HMM: 3-168/174.0
DYKRIQIYPSIILPKQLYLGKGDQAtNKKIMEDLKITHIVNITQEH---------------KSAFPESIEYLTLQLDDVPQTQLINfFEKTTKFLSDAID
|| .       . .. |..|.|  | . . . .|.||..|. ..|.               ..  .. |.|| |  .|     |   ...  ||. .|. 
dyinaspldlsyitprliagqgpla.fwemlkelgittvvmlleekelglykcinywpelredlerlgiqylylpwpDhgvpdlsi.llefvkfveeals

G--GGCVMVHCNMGVSRSSSVTLAYLIKSKRW-TLGEAYSFIKERR---SCVRPNRGFLKQLATWEEM
   ||.| |||..||.|.  . .|||..   . .| .|.....|.|   ... .. .....|  .| .
edpggpvlVHCsaGvgRtGtlvaaylmlrglleslvdaldlvrelRlqrpgmvqtpsQyrflyyfekl
0051082 (Phosphotyrosine protein) phosphatases II 340-472 2.7e-21 71.2 In-house 11-149 (151) alignment 
Range on Protein: 340-472
Range on HMM: 11-149/151.0
ILPKqLYLGKGDQATNKKIMEDLKITHIVNITQEH-----KSAFPE-SIEYLTLQLDDVPQTQLINFFEKTTKFLSDAIDG-GGCVMVHCNMGVSRSSSV
. .  ||.. |  | . . ...|.|..|||...|.     .. .|| .||.| ....| | ..|  .|.   .||. ..|  .|.| |||..|..|.  .
vtgg.lyrsggpladflellkelgiktivnlrseeergycpeylpelgievlhipildwpdpglplsfdavleflellldkkngpvlvHCsaGkgRTGtl

TLAYLIKsKRWTLGEAYSFIKERRS-CVRPNRGFLKQLATW
 ..||..  ...| ||.......|  .|.|| .||.||  .
valylml.lgvsleealeeyrlkrpgvvqpnqqflfqlfal
0042113 (Phosphotyrosine protein) phosphatases II 340-473 2.6e-20 68.3 In-house 49-239 (245) alignment 
Range on Protein: 340-473
Range on HMM: 49-239/245.0
ILPKQLYLGKGDQATNKK----IMEDLKITHIVNITQEH----------------------------------------------KSAFPESIEYLTLQL
  ....... | .. . .     . .|.||.||..|.|.                                              ..   | | |. |  
ritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywplgesltygdftvtllseehlddytvrtlevtnlgddesrevihyhylpw

DDVPQTQLINFFEKTTKFLSDAID--GGGCVMVHCNMGVSRSSSVTLAYLI-----KSKRWTLGEAYSFIKERRSCVRPNRGFLKQLATWE
.| . . |.. ...  .|. .|.   ..| |.|||..||.|.  . .|||.     | ....| ||. .....|...... .....|  ..
pdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylmleqlekelgvsleeavkelrsqRpgavqtpsqyrflyeal
0040438 (Phosphotyrosine protein) phosphatases II 358-481 4.1e-20 67.7 In-house 105-280 (317) alignment 
Range on Protein: 358-481
Range on HMM: 105-280/317.0
IMEDLKITHIVNITQEHKSA---------------------------FPESIEYLTLQLDDV----------------P-------QTQLINFFEKTTKF
 . ....|.||..|..                                 ..|...||.. |                 |        ..|..|.|.  ..
mvweqgvtvivmLteleelgrekcaqYwplgetltygdftvtllseeelagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfleavrea

LSdaiDGGGCVMVHCNMGVSRSSSVTLAYLI-----KSKRWTLGEAYSFIKERRSCVRPNRGFLKQLATWEEMILGKRF
|.   |.||.|.|||..||.|. .. .|||.     | ..... ||. ...|.|... .. .....| ... ..| .. 
le...dpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalleylkrkl
0038934 (Phosphotyrosine protein) phosphatases II 363-477 8.5e-19 63.4 In-house 56-177 (194) alignment 
Range on Protein: 363-477
Range on HMM: 56-177/194.0
KITHIVNITQEH-----KSAFPESIEYLTLQLDD---VPQTQLINFFEKTTKFLSDAiDGGGCVMVHCNMGVSRSSSVTLAYLIKSKRWTLGEAYSFIKE
|.......| ..     .      |||| |.  |   ||...... | .  ..  .. | ||.| ||| .|..|.  .  ||||.. .... ||. ...|
klglvidltnteryYdpeefekagieylklpfpddgtvPsleillrfldlvdeflne.dpggvvaVHCkaGlgRtGtlvaaYLiyrlgmsaeeAialfre

RRSCVRPNRGFLKQLATWEEMIL
.|  . ||...|..| .. ... 
kRpgaipnqdyleallkrykelr
subfamily_Sponge-DSP-Subfam1_pd Subfamily Sponge-DSP-Subfam1 344-473 1.9e-18 59.9 In-house 5-138 (145) alignment 
Range on Protein: 344-473
Range on HMM: 5-138/145.0
QLYLGKGDQATNKKIMEDLKITHIVNITQEH----KSAFPESIEYLTLQLDDVPQTQLINFFEKTTKFLSDAIDGGGCVMVHCNMGVSRSSSVTLAYLIK
.|| | . .| .  ....| |. |||..  .    ...  |||| | .  .|.   .| . |.. | |.    . |  |.|||  ||||| .|..|.|.|
rlyvgsalhandvptlqelgisrivnmaagslvasqelksesieillitaedlesydlsqhfdevtdfidkgkeegagvfvhcmagvsrsvtvsvaflmk

SKRWTLGEAYSFIKERRSCVRPNRGFLKQLATWE
    || ||   .. .|    ||  |||.|   |
ycnmtlseaarqvrsnrllaypnvtflknllnle
0036941 (Phosphotyrosine protein) phosphatases II 361-482 2.4e-18 61.9 In-house 100-282 (297) alignment 
Range on Protein: 361-482
Range on HMM: 100-282/297.0
DLKITHIVNITQEHKSAF-------PES---------------------------------------------IEYLTLQLDDVP--QTQLINFFEKTTK
....|.||..|..    .       |.                                              . |..   ..||   ..|..|.|.  |
eqnvtvIvmltelvelgrekcaqywpleegesltygdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfielvrk

FLSDAiDGGGCVMVHCNMGVSRSSSVTLAYLI--------KSKRWTLGEAYSFIKERRSCVRPNRGFLKQLATWEEMILGKRFT
.|. .  .|| |.|||..||.|| .. .|.|.        | ..... ||. ...|.| .. .. .....|  .. . | |. |
vlkll.psggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallellkkklt
0039614 (Phosphotyrosine protein) phosphatases II 357-480 3.5e-18 61.5 In-house 119-292 (297) alignment 
Range on Protein: 357-480
Range on HMM: 119-292/297.0
KIMEDLKITHIVNITQEHKSAFpES--------------------------IE-------------------YLTLQLDDVP--QTQLINFFEKTTKFLS
. . ....|.||..|..                                  .                    |.    ..||   ..|..|.|.  ..|.
rmvweqgvtvivmLtklvelgr.kcaqywpeeggtygdftvtllkvehldgytvrtlevtnngesrtvthfqytgwpdhgvppslellleflelvreala

DAiDGGGCVMVHCNMGVSRSSSVTLAYLI-----KSKRWTLGEAYSFIKERRSCVRPNRGFLKQLATWEEMILGKR
 . ..||.| |||..||.|. .. .|||.     | ..... ||.....|.|...... .....|  .. . | ..
el.pkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydallellkrk
0051429 (Phosphotyrosine protein) phosphatases II 333-477 1.2e-17 59.9 In-house 12-225 (272) alignment 
Range on Protein: 333-477
Range on HMM: 12-225/272.0
IQIYPSIILPKQLYLGKGD---QATNKKIMEDLKITHIVNITQEHK------SAFPESIEYLTLQLDDVPQTQLINFF----------------------
.  | . ..|. ||.. |     | . . ...|.|..||....|.       . ... |.|| | . |   ..   ..                      
vggygrvvkpgrlyrsggplpltaadfwrlkelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseellldyilrelllt

--------------------------EKTTKFLSDAIDgGGCVMVHCNMGVSRSSSVTLAYLIKsKRWT--------------LGEAYSFIKERRSCVRP
                          |   ..|.   | || |.|||. |..|.  | ...|.   ...              | ||.. ....| ....
lllsagearevmhlhytdwpdhgvpqeallellellld.ggpvlvHCsaGkdRTGtvvalllll.lgvsletivddYlltnlyleeaveelraqrpgavq

NRGFLKQLATWEEMIL
. .....|  ..  .|
teeqylflyeallell
subfamily_PTPMT1_pd Subfamily PTPMT1 358-476 1.5e-17 58.6 In-house 53-168 (171) alignment 
Range on Protein: 358-476
Range on HMM: 53-168/171.0
IMEDLKITHIVNITQEHKSAfpeSIEYLTLQLDDVPQTQLINFFEKTTKFLSDAIDGGGCVMVHCNMGVSRSSSVTLAYLIKSKRWTLGEAYSFIKERRS
. |. ......| |.|.|.     .|.|.|.  |. ..  ..  ||. .|... .. | .| |||. | .||...  .||.|...... || ...|..|.
lneeyelkalansteewkkl...gveqlqlatvDfteapdleklekgvefiekvaskgkrvYvHCkaGrgRsatlvacylmkkeklspeeAlkalkkkRk

CVRPNRGFLKQLATWEEMI
 .| ..  .|.|  .|| .
iirlakkqwkalqeyeekl
0043336 (Phosphotyrosine protein) phosphatases II 357-472 2e-16 55.8 In-house 106-272 (278) alignment 
Range on Protein: 357-472
Range on HMM: 106-272/278.0
KIMEDLKITHIVNIT-----------------------------------------------QEHKSAFPESIEYLTLQLDDVP--QTQLINFFEKTTKF
. . .|..|.||..|                                               ....| .   . ||    ..||   ..|..| ..  ..
rmvwelgvttivmLtelvelgrvkcaqYwpggsltygdftvtllkeehlddytvrtlevtnlgdgesrtvthyhylgwpdhgvpeslsllldflkavrea

LSdaiDGGGCVMVHCNMGVSRSSSVTLAYLI-----KSKRWTLGEAYSFIKERRSCVRPNRGFLKQLATW
|.   | .|.|.|||. ||.|.  . ..||.     | ....| ||.....|.| .  ..  ....|  .
le...dsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflyea
subfamily_MSG5_pd Subfamily MSG5 322-476 7.8e-16 51.6 In-house 8-160 (165) alignment 
Range on Protein: 322-476
Range on HMM: 8-160/165.0
KQFYQLEDYKRIQIY---PSIILPKQLYLGKgdqatNKKIMEDLKITHIVNITQE---HKSAFPEsIEYLTLQLDDvpQTQLINFFEKTTKFLSDAIDGG
... . | ..  ..|   | ..||..|||       . |. | | .  ..|...|    .   |  ..|  .. .   .....  . . |. .  |   .
ielvhaeildvrrvyldgpllvlpeklylys.....epklkellsfdlvinvakeindlellvpa.vkyyhieweh..dskivkdlsrltriihaatskr

GCVMVHCNMGVSRSSSVTLAYLIKSKRWTLGEAYSFIKERRSCVRPNRGFLKQLATWEEMI
  ..|||. |.|||.|. .||..|    .| .||  .| .   . |. |.. ||  || ..
kkilvhcqcglsrsaslivayimkyynlslrdaydklksvaddispsiglifqlmeweval
0047943 (Phosphotyrosine protein) phosphatases II 361-469 2.3e-12 42.4 In-house 99-264 (273) alignment 
Range on Protein: 361-469
Range on HMM: 99-264/273.0
DLKITHIVNITQEHKSAFPES---------------------------------------------------IEYLTLQLDDVP--QTQLINFFEKTTKF
. ....|| .|...    .                                                     . |..   ..||   ..|..|.|.  |.
eqnvrviVmLtelvelgrekcaqYwpleggelsltygkftvtllseetkddytvrtleltnlgtgesrtvthfhytgwpdhgvppslesllefielvrka

LSDAIDGgGCVMVHCNMGVSRSSSVTLAYLI-----KSKRWTLGEAYSFIKERRSCVRPNRGFLKQL
|. .... | |.|||. ||.|. .. ...|.     | ..... ||. .....| .. ..  ....|
lealpsn.gpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrfl
0050432 (Phosphotyrosine protein) phosphatases II 361-461 2e-10 36.0 In-house 130-283 (308) alignment 
Range on Protein: 361-461
Range on HMM: 130-283/308.0
DLKITHIVNITQEHKSAFPESIEYLTLQLD---------------------------------------------------DVPQ--TQLINFFEKTTKF
. ....|| .|...    .   .|  | |.                                                   .||.  ..|..|.|.  |.
eqnvrvIvmLtklvengrekcaqYwplelgggsleygkftvtllseevlddytvrtleltnlgdgesrtvthfhytnWpdhgvPpspeilldflelvrks

LsdaidGGGCVMVHCNMGVSRSSSVTLAYLI-----KSKRWTLGEAYSFIKERRSCVRP
|     .|| ..|||. ||.|.  . ...|.     | ..... ||. ...|.| .. .
l.....pggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvq
0051299 (Phosphotyrosine protein) phosphatases II 362-462 2.7e-10 35.7 In-house 115-271 (288) alignment 
Range on Protein: 362-462
Range on HMM: 115-271/288.0
LKITHIVNITQEHKS-----------------------------------------------AFPESIEYLTLQL-----DDVP--QTQLINFFEKTTKF
 ....|| .|...                                                    ||...  ..      ..||   ..|..| ..  |.
qnvrvIvmltklvelgrekcaqYwplggsltygditvtllseevlddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpdspellldflrlvrka

LSdaiDGGGCVMVHCNMGVSRSSSVTLAYLI-----KSKRWTLGEAYSFIKERRSCVRPN
|.   .|||.|.|||. ||.|.  . ...|.     | ..... ||. ...|.| .. ..
la...sgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqt
0046845 (Phosphotyrosine protein) phosphatases II 364-459 6.6e-10 34.3 In-house 102-256 (284) alignment 
Range on Protein: 364-459
Range on HMM: 102-256/284.0
ITHIVNITQEH--------------------------------------------------KSAFPESIEYLTLQLDDVP--QTQLINFFEKTTKFLSDa
...|| .|...                                                  .| .   . |..   ..||   ..|..|...  ..|.. 
vrvIVmltelvengrekcaqYwplegevltygdftvtllseevkddytvrtleltnlgytgesrtvthfhytswpdhgvppspedlleflrlvrellen.

IDGGGCVMVHCNMGVSRSSSVTLAYLIKSK--------RWTLGEAYSFIKERRSCV
..||| ..|||  ||.|.  . ...|...         .... ||.....|.| . 
lpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgm
0048567 (Phosphotyrosine protein) phosphatases II 374-457 9.5e-09 29.8 In-house 31-119 (157) alignment 
Range on Protein: 374-457
Range on HMM: 31-119/157.0
HKSAFPESIEYLTLQLDD--VPQTQLINFFEKTTKFLSDAIDGGGCVMVHCNMGV---SRSSSVTLAYLIKSKRWTLGEAYSFIKERRS
.   ... . |...  |.   . ..|..|. |  |||..    |. ..||| .|    .|.  .  .|||.  ..|  ||. ...  | 
lyFsiddglvyedfffdfGPlnlailyrFilklnkflkilelagkaiavhckaglkkrgrtatLigcYlilhlgftpeeaiaplrivrp
subfamily_Laforin_pd Subfamily Laforin 380-459 1.2e-08 28.0 In-house 75-154 (183) alignment 
Range on Protein: 380-459
Range on HMM: 75-154/183.0
ESIEYLTLQLDDVPQTQLINFFEKTTKFLSDAIDGGGCVMVHCNMGVSRSSSVTLAYLIKSKRWTLGEAYSFIKERRSCV
| . |. | ..|.     .. . ..  .|   .. |  | |||| || ||...   .|     |.|     |.  .| .|
eglayiwlptedlstesrvenlpqavyllhallekghivyvhcnagvgrstaivcgflqyvlgwslakvqyfllakrpvv
subfamily_DSP23_pd Subfamily DSP23 355-457 1.5e-07 26.1 In-house 23-126 (148) alignment 
Range on Protein: 355-457
Range on HMM: 23-126/148.0
NKKIMEDLKITHIVNITQEHKS---AFPeSIEYLTLQLDDVPQTQlINFFEKTTKFLSDAIDGGGCVMVHCNMGVSRSSSVTLAYLIKSKRWTLGEAYSF
. . . || . ..| .|.| .    | | .. .  |..||      ..  ..  . . .| . .  | ||| .|  |. ..   ||.| .. . .|| . 
qyrylldlgvrylvslteegrphveatp.nltlvrlriddyhppa.leqvvefvrvveeaeekneavsvhcllgrgrtgtmlacylvkerklaaaeaiae

IKERRS
....| 
vrrlrp
subfamily_PTEN_pd Subfamily PTEN 363-457 7.3e-07 24.3 In-house 63-157 (184) alignment 
Range on Protein: 363-457
Range on HMM: 63-157/184.0
KITHIVNITQEHKSAFPESIEYLTLQLDDVPQTQLIN-FFEKTTKFLSDaiDGGGCVMVHCNMGVSRSSSVTLAYLIKSKRWTLG-EAYSFIKERRS
||  .    .  .. | . .  . .. .  |. .|.. . |. .|.|.   |    |.|||..|  |.  .. |||.||. ..   || .. .| |.
kiynlrserkydskkfdgrvavypfdDhnppplelleeivediekwlee..dkknvvvvHCkaGkGRtGvlivayllkslllekaeealelfaeaRt
subfamily_RNGTT_pd Subfamily RNGTT 363-458 8.3e-07 22.9 In-house 54-156 (189) alignment 
Range on Protein: 363-458
Range on HMM: 54-156/189.0
KITHIVNITQEHKSAFPE-----SIEYLTLQLD---DVPQTQLINFFEK-TTKFLSDAidGGGCVMVHCNMGVSRSSSVTLAYLIKSKRWTLGEAYSFIK
|.  ....|....    |      |.|  ||     . |... .. | |  ..| ..       . |||  |  |.  .  .||.. . | . .| .  .
klglvidltntsryYdkeelekegikyvklqcagkgeaPeaeqvkefiklveeffkkn..peevigvhCthGfnRtGFlivsyLvekedwsveaavalFa

ERRSC
. |  
kaRpp
subfamily_PTPDC1_pd Subfamily PTPDC1 384-477 1.6e-06 22.7 In-house 85-176 (182) alignment 
Range on Protein: 384-477
Range on HMM: 85-176/182.0
YLTLQLDDVPQTQlINFFEKTTKFLSDAIDGGgCVMVHCNMGVSRSSSVTLAYLIKSKRWTLGEAYSFIKERRSCVRPNRGFLKQLATWEEMIL
.  . ..|   .  ..      | .. |.. |  | |||  |  |   .  .||. .|| |  .| ......|.     |. .. .  .. ...
vynfgwkDygvas.leriLdivkvvafalqeg.kvavhChaGlGrtGvliacylvyakrltaekaiklvrskrpksiqtreqvelvkefalfli
subfamily_VSP_pd Subfamily VSP 355-457 2.4e-06 21.7 In-house 69-171 (212) alignment 
Range on Protein: 355-457
Range on HMM: 69-171/212.0
NKKIMEDLKITHIVNITQEHKSAFPESIEYLTLQLDDVPQ-TQLINFFEKTTKFLSDaiDGGGCVMVHCNMGVSRSSSVTLAYLIKSKRWT-LGEAYSFI
..|  .  |.  .    .  .. | .... ....  .||.  .|..| ..  ..|..  |    ...||  |  |. ..  |.|..|. ..   |.  ..
dtkhrdhykvvnlcseraydekyfnnrvkriliddhnvpkleellvftkevkewlek..dlknvlaihckGGkgrtGtivcalllaseifetakesldyf

KERRS
 |||.
gerrt
subfamily_DSP11_pd Subfamily DSP11 381-459 2.5e-06 21.5 In-house 79-160 (178) alignment 
Range on Protein: 381-459
Range on HMM: 79-160/178.0
SIEYLTLQL--DDVPQTQLINFF-EKTTKFLSDAIDGGGCVMVHCNMGVSRSSSVTLAYLIKSKRWTLGEAYSFIKERRSCV
...|| |.    .||. .|.. | |. ..|| .  | .  . |||  || |.  .   |||. . .   .| .  .| |   
gvkylklncpGhevpkeelvkkfkeavkefleknkdndkligvhCthGvnrtGyliCrylidvegyepedaieafeearGhs
PTPc_DSPc_SM00012 384-441 5.4e-06 21.9 In-house 7-65 (105) alignment 
Range on Protein: 384-441
Range on HMM: 7-65/105.0
YLTLQLDDVPQ--TQLINFFEKTTKFLSDAIDgGGCVMVHCNMGVSRSSSVTLAYLIKSK
|.. .   ||.  . ........ |. ... . .. |.|||  ||.|.  ....... ..
ytgwpdhgvPeesdsilellravkknknkses.skpvvVhCsaGvgRtgtfvaldillqq