Gene RNGTT in Nematostella vectensis

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family DSP
Subfamily RNGTT
Protein sequence
ID Type Fasta BLAST phosphatome Note
NvecP020_AA protein Get Run
NvecP020_AA_11-181 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_RNGTT_pd Subfamily RNGTT 4-193 1.5e-97 318.8 In-house 1-189 (189) alignment 
Range on Protein: 4-193
Range on HMM: 1-189/189.0
PPRWLNCPRKSQVIADRFFAFKTPLSSRYDDQIPEANRFQLPMLCSYFQTLKVKVGLIIDLTNTNRFYDKNELERLtGIKHVKLQCRGHGETPSPDQTQL
|.||||||||...||..|..||||||.||||...|.|||.. ||.||..|||||.||.||||||.|.|||.|||.  |||.|||||.|.||.|...|.. 
PerWlnCPrkgkliaekflpfktplskrydddlaeenrfepsmllsylktlkvklglvidltntsryYdkeeleke.gikyvklqcagkgeaPeaeqvke

FINICCRYWDKNPGELIGVHCTHGFNRTGFLIISYLVEKEDWSIEAAVECFTKCRPPGIYKQEYLNELSRRYGDSADPPSAPELPDWCYE
||........||| |.||||||||||||||||.||||||||||.||||..|.|.|||||||..||.|| |||.|... ..||||||||.|
fiklveeffkknpeevigvhCthGfnRtGFlivsyLvekedwsveaavalFakaRppGiykedylkellrrYadveeaiaapelpdwcle
0038934 (Phosphotyrosine protein) phosphatases II 3-195 1e-60 200.0 In-house 2-193 (194) alignment 
Range on Protein: 3-195
Range on HMM: 2-193/194.0
IPPRWLNCPRKSQVIADRFFAFKTPLSSRYDDQIPEANRFQLPMLCSYFQTLKVKVGLIIDLTNTNRFYDKNELERLtGIKHVKLQCRGHGETPSPDQTQ
.|.|||...| ...| .|| |||.|||...|..|.| .|| ...|..|...|.||.||.||||||.|.||..|.|.. ||...||.. ..|..|| ....
lPdrwlkyervgdiitgrfiafkvPlsgsldkyieelyrfspedlvrylkllnvklglvidltnteryYdpeefeka.gieylklpfpddgtvPsleill

LFINICCRYWDKNPGELIGVHCTHGFNRTGFLIISYLVEKEDWSIEAAVECFTKCRPPGIYKQEYLNELSRRYGDSADPPSAPELPDWCYEDE
 |.... .. ...||....|||..|..|||.|...||... ..| |.|.. |. .||..|..|.||..| .||..  . . ||| |....|||
rfldlvdeflnedpggvvaVHCkaGlgRtGtlvaaYLiyrlgmsaeeAialfrekRpgaipnqdyleallkrykelrkavlapekpelllede
subfamily_DSP11_pd Subfamily DSP11 3-176 1.2e-44 146.3 In-house 1-175 (178) alignment 
Range on Protein: 3-176
Range on HMM: 1-175/178.0
IPPRWLNC-PRKSQVIADRFFAFKTPLSSRYDDQIPEANRFQLPMLCSYFQTLKVKVGLIIDLTNTNRFYDKNELERlTGIKHVKLQCRGHGEtPSPDQT
.| || .  | ....   || ||||||....|....| .||    | .  |  . |.||.||||||.|.|.|.||.  .|.|..||.| ||   |. .  
vPdrwkkykpvgdkiegtrfiafktPlkesfdkkveeekrftpkdLleklqeknkklGLvidltntdryykkkeltd.egvkylklncpGhev.pkeelv

QLFINICCRYWD--KNPGELIGVHCTHGFNRTGFLIISYLVEKEDWSIEAAVECFTKCRPPGIYKQEYLNELSRRYG
. |..   .. .  |. ..||||||||| ||||.||  ||...|... | |.| | ..|   . ...||..| ..  
kkfkeavkefleknkdndkligvhCthGvnrtGyliCrylidvegyepedaieafeearGhslerenylkdLkklek
mRNA_cap_enzyme mRNA capping enzyme, catalytic domain 272-368 1.3e-33 105.6 Pfam-A 1-98 (192) alignment 
Range on Protein: 272-368
Range on HMM: 1-98/192.0
QPVSMDRQNIRFLHEKDYRVSWKADGTRYMMLVVGEgQVYLIDRDNAVFSAPQFRFPQRKN--PREHIFDTLIDGEMVFDKEGDKIHPRYLAYDIIKFQ
||||..|.|...|..||| ||.||||.|...|.  . .|||||||| |.  ....|| ...  ....  .||.|||.|.|.  .. ..||| |||....
qpvslsrenlkllkqkdYyvseKaDGlRvlllitkk.evylidrdnevylvenlkfplklekekekvhhgtllDGElvidtveeeqklryliyDilain
mRNA_cap_C mRNA capping enzyme, C-terminal domain 454-550 1.1e-30 95.5 Pfam-A 2-105 (105) alignment 
Range on Protein: 454-550
Range on HMM: 2-105/105.0
LNSVDFILKIATVKQEGCLPRSVGYL-MV-GGFDrPF----AEIKVTKELKAYNNRVIECTWDN--KEWKFLRVREDKSHANAYTTAQGVCESIRNPVTK
||.|||.||. . ...| |....|.|  | ||.| .|       |.....| ......||..|.  ..|||||.|.|||..| . ||. |..||...|||
lntvDfllklekeeedglLeeekgkldyveggsd.efitakekeklksdekelkgkIvEcklddkkgrWkflriRkDKsepNsistaekvlksiednvtk

EWLLE
| |||
eeLle
0036282 (Phosphotyrosine protein) phosphatases II 16-171 6.3e-23 76.8 In-house 14-162 (174) alignment 
Range on Protein: 16-171
Range on HMM: 14-162/174.0
VIADRFFAFKTPLSsryddQIPEANRFQLPMLCSYFQTLKVKVGLIIDLTNTnrfydKNELERLTGIKHVKLQCRGHGETPSPDqTQLFINICCRYWDKN
.| .|..|.. ||.      ...  .... .. .. .    . ...|.....     . | .. .||....| . .||. ...   . |.... ..  ..
yitprliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe.....lredlerlgiqylylpwpDhgvpdlsi.llefvkfveealsed

PGELIGVHCTHGFNRTGFLIISYLVEKEDW-SIEAAVECFTKCR---PPGIYKQEYLNEL
||  . |||..|..|||.|.. ||...  . | . |.. . ..|   |.... ....  |
pggpvlVHCsaGvgRtGtlvaaylmlrglleslvdaldlvrelRlqrpgmvqtpsQyrfl
0041856 (Phosphotyrosine protein) phosphatases II 50-171 6.6e-22 73.4 In-house 51-168 (182) alignment 
Range on Protein: 50-171
Range on HMM: 51-168/182.0
YFQTLKVKVGLIIDLTntNRFYDKNELeRLTGIKHVKLQCRGHGETPsPDQTQLFINICCRywdknPGELIGVHCTHGFNRTGFLIISYLVEKEDWSIEA
. .  . ....|..||  .. |. ..|   .||....|.. .|| .. .|..  ||... .     .|. . |||..| .|||.|.. ||..| ..|.| 
lrmlkelgittivnlt..eelywpell.erlgiqylylpwpDhgvpd.ldelldfieevle.....eggpvlVHCsaGvgRtgtlvaaylmkklgvslee

AVECFTKCRP-----PGIYKQEYLNEL
||. . ..||     |  |  ..| .|
avklvrsrRpgmvitpnqyfflqlall
0043147 (Phosphotyrosine protein) phosphatases II 27-171 7.4e-22 73.3 In-house 28-153 (172) alignment 
Range on Protein: 27-171
Range on HMM: 28-153/172.0
PlssryddqipeanrFQLPMLCSYFQTLKVKVGLIIDLTNTnrfYDKNELERLTGIKHVKLQCRGHGETpSPDQTQLFINICCRYWDKNPGELIGVHCTH
|              .. ..   . .  . ....|..||.    .   ||.  .||..  | .  || . .... . |.... ..  ..||. . |||..
p..............lrntladfwrmlkelgithivnltel...lydpellerlgiqylylpwpDhgvp.llellleflefidellalspggpvlVHCsa

GFNRTGFLIISYLVEkEDWSIEAAVECFTKCRPPGIYKQEYLNEL
|..|||.|.. ||.. ...|.| ||. . ..|| ... ..... |
GvgRtgtlvaaylml.lglsleeavalvrekRpgavqnpsqyrfl
0044763 (Phosphotyrosine protein) phosphatases II 52-172 1.1e-21 72.7 In-house 43-164 (178) alignment 
Range on Protein: 52-172
Range on HMM: 43-164/178.0
QTLKVKVGLIIDLTNTNRFYD---KNELERLTGIKHVKLQCRGHGETPSPDQTQLFINICCRYWDkNPGELIGVHCTHGFNRTGFLIISYLVEKEDWSIE
.  . ....|..||.. . .      .  . .||..... . .||......... |.... .. | ..|. . |||..|..|.| |.. ||. | ..|.|
llkelgithivnlteelelgflkcdpywpeeagiqylhipipDhgvpdllehflefvefieeald.ekggpvlVHCsaGvgRsgtlvaaylmkklglsle

AAVECFTKCRPpGIYKQEYLNELS
.|.| . ..|| ... ...|. | 
eaielvrerRp.ivpnpgqlrqLy
0048179 (Phosphotyrosine protein) phosphatases II 42-171 1.2e-21 72.4 In-house 14-137 (144) alignment 
Range on Protein: 42-171
Range on HMM: 14-137/144.0
FQLPMLCSYFQTLKVKVGLIIDLTNTnrfYDKNELERLtGIKHVKLQCRGHGETPSPDQTQLFINICCRYWDknPGELIGVHCTHGFNRTGFLIISYLVE
  ||..... .  | .....|.||..   |....|||  ||....| . .||  ..... . |.... .. .  .|. . |||..|..|||.|.. ||. 
gslptaldlellkklgittvinltee...yepeflere.giqylhlpwpDhgvpdllellleflefieeale..eggpvlVHCsaGvgRtgtlvaaylmk

KEDWSIEAAVECFTKCRPPGIYKQEYLNEL
|...|.| |.. . ..|| ... ...|. |
klglsleealalvrsrrpgavpnpgqlrfL
0048076 (Phosphotyrosine protein) phosphatases II 44-173 5e-21 70.3 In-house 16-137 (145) alignment 
Range on Protein: 44-173
Range on HMM: 16-137/145.0
LPMLCSYFQTLKVKVGLIIDLTNTNRFYDknelerLTGIKHVKLQCRGHGETPSPDQTQLFINICCRYWDKNpgELIGVHCTHGFNRTGFLIISYLVEKE
||. ... .  . .......||.. ...        .||... | . .||. ..... . |.... .. ...  . . |||..| .|||.|.. ||. ..
lptaldlellkdlgittvlnltselelle......rlgiqylylpwpDhgvpdllellleflefieealkeg..gpvlVHCsaGvgRtgtlvaaylmlll

DWSIEAAVECFTKCRPPGIYKQEYLNELSR
..|.| |.| . ..|| ... ...|. | .
gvsleealelvrsqrpgavpnpgqlrflye
0040438 (Phosphotyrosine protein) phosphatases II 50-169 6.2e-20 67.1 In-house 109-266 (317) alignment 
Range on Protein: 50-169
Range on HMM: 109-266/317.0
YfqtlkvKVGLIIDLTNTNRFYD----------------------KNELErLTGIKHVKLQCR-------------------GHGETPSPDQTQLFINIC
.      .|..|. ||..  . .                      ..| | | ||.. .|..                     ||  ||||. . |....
q......gvtvivmLteleelgrekcaqYwplgetltygdftvtllseee.lagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfleav

CRYWDkNPGELIGVHCTHGFNRTGFLIISYLV-----EKEDWSIEAAVECFTKCRPPGIYKQEYLN
 .. . .||. . |||..| .|||..|. ||.     .......| ||. . ..|| ...  |.. 
reale.dpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyr
0049772 (Phosphotyrosine protein) phosphatases II 50-159 1.5e-19 66.3 In-house 162-255 (314) alignment 
Range on Protein: 50-159
Range on HMM: 162-255/314.0
YFQTLKvkvgliidltntNRFYDKNELeRLTGIKHVKLQCRGhGETPSPDQTQLFINICCRYwdkNPGELIGVHCTHGFNRTG-FLIISYLVEKEDWSIE
....||            .. ||.. .   .|||.. . . . |..|.... . |.... ..   ..|. . |||..| .||| |... ||. . ..|.|
dlellk............eelydpelf.erlgikylripvpD.gsaplledfdeflefieea...dkggpvlvHCkaGkgRtgtfvvaaylmkllgvsle

AAVECFTKCRP
 |.| . ..||
ealedvrlkRp
0049260 (Phosphotyrosine protein) phosphatases II 45-171 2.5e-19 64.9 In-house 19-142 (152) alignment 
Range on Protein: 45-171
Range on HMM: 19-142/152.0
PMLCSYFQTLKVKVGLIIDLTNTNRFYdKNELERLTGIKHVKLQCRGHGeTPSPDQTQLFINICCRYWDKNPGELIGVHCTHGFNRTGFLIISYLVEkED
|. .. |  .  . |  . .. |.... ...|    .|..  |..  || .|. .|  ||... .. . ...|. . |||..|..|||.|.. ||..  .
pntladfwrmlkelgittivmltelle.lgklkceqyiqylhlpwpDhg.vpdlsqlllflllfieklaldkggpvlVHCsaGvgRtgtlvaaylml.lg

WSIEAAVECFTKCRPPGIYKQEYLNEL
.|.| ||. . ..|| ... ...|  |
vsleeavalvrekRpgavpnpgqlrfl
0037934 (Phosphotyrosine protein) phosphatases II 19-168 8.4e-19 63.5 In-house 44-231 (243) alignment 
Range on Protein: 19-168
Range on HMM: 44-231/243.0
DRFFAFKTPLSSRYDDqipeANRFQLPMLCSYfqtlkvKVGLIIDLTNTN----------------------------------------RFYDKNELEr
.|..|.  ||.. ..|    .    . || ..      ... |..||..                                         . .| ..|. 
prliatqgPlpetved....dlasfwrmlwel......gitvivmltelvElgrekcaqywpgevtygdftvtllseehlddytvrtlllenldlddlt.

LTGIKHVKLQCRGHGETPSPDQTQLFINICCRYWDK-------NPGELIGVHCTHGFNRTGFLIISYLVEKE-DWSIEAAVECFTKCRPP-GIYKQEYL
...|..  |   .||  .||.. . |..... . ..       ..|. . |||..| .||| ||. ||. .  ....| ||. . ..||  ..  ....
rlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRtGtliaaylmllllgvdleeavkllreqRpgkavqtpsqy
PTEN_1 3-172 1.8e-18 62.0 In-house 15-185 (196) alignment 
Range on Protein: 3-172
Range on HMM: 15-185/196.0
IPPRWLNCPRKSQVIADRFFAFKTPLSSrydDQIPEANRFQLPMLCSYFQTLKVK-VGLIIDLTNTN---RFYDKNELERLTGIKHVKLQCRGHGeTPSP
.| ..|.... .  | . ..|. .|| .     ..  .| .|. . .....|| . . |...|..     .. . .|...  |... ..  . || .|| 
lptelldltyitsriiamgkapsrpllq...eideglyrgslkdvaadldnlkedgitlvvnlseeeelsgrsydleeffksgveylhfpieDhg.apsl

DQTQLFINICCRYWDKNP-GELIGVHCTHGFNRTGFLIISYLVEKEDWSIEAAVECFTKCRPPGIYKQEYLNELS
.. . ... .  .. ..| |. . |||..| .|.|.....||..|. .. . |.| . ..||||   . ....| 
selfdicksfiewllsdpngnvVlVHCkaGlgRsGtvvaayLmykgkltadeAlelvrekRppgapnspsqerll
0042113 (Phosphotyrosine protein) phosphatases II 41-168 2.8e-18 61.7 In-house 56-232 (245) alignment 
Range on Protein: 41-168
Range on HMM: 56-232/245.0
RFQLPMLCSYF----QTLKVKVGLIIDLTNTNRFYDK----------------------------------------NELERLTGIKHVKLQCRGHGETP
..| |.  ..     .  . ..  |..||..  .  .                                         . | ...| .  | . .||...
atqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywplgesltygdftvtllseehlddytvrtlevtnlgddesrevihyhylpwpdhgvpd

SPDQTQLFINICCRYWDKNPGELIGVHCTHGFNRTGFLIISYLV-----EKEDWSIEAAVECFTKCRPPGIYKQEYL
.... . |.... ..  ..... . |||..| .||| .|. ||.     .  ..|.| ||. . ..||  .  ....
llellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylmleqlekelgvsleeavkelrsqRpgavqtpsqy
0040439 (Phosphotyrosine protein) phosphatases II 22-169 4e-18 61.4 In-house 57-236 (249) alignment 
Range on Protein: 22-169
Range on HMM: 57-236/249.0
FAFKTPLSSryddqipeanrfqlpMLCSYF-QTLKVKVGLIIDLTNTNRF-------------------------------------------YDKNElE
 |...||..               .. ... .  . ... |..||.. ..                                           ||...  
iatqgPlpe...............tvedfwrmlwelgitvivmLtslvelgrekcaqywplggsleygdftvtllsvevkddytvrtleltnlydges.r

RLTGIKHVKLQcrGHGETPSPDQTQLFINICCRYWDKN-PGELIGVHCTHGFNRTGFLIISYLV-----EKEDWSIEAAVECFTKCRPPGIYKQEYLN
. ..| ....    ||  ||....  ||...  . ... .|. . |||..| .|||..|. ||.     .. ....| ||. . ..|| ... .|.. 
tvlhiqytdwp..dhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaaylmleqlekelgvdleeavkllrsqRpgavqnpeqyr
mRNA_cap_enzyme mRNA capping enzyme, catalytic domain 387-450 2.1e-17 52.7 Pfam-A 128-192 (192) alignment 
Range on Protein: 387-450
Range on HMM: 128-192/192.0
QQGLLNKTQEPFSIRAKQFFPLEKTAW-ILEHWVPKLTHENDGLIFNPAEDPYLPGRQASVLKWK
.........|||..| |.|..|....  . .. ..|| ||.||||| ....||..||. ..||||
kthiiktelepfkvrlksfilllalekllskkkikklsheiDGLIfqsvdtpYvagrdknllKWK
0051082 (Phosphotyrosine protein) phosphatases II 43-163 2.2e-17 58.5 In-house 19-137 (151) alignment 
Range on Protein: 43-163
Range on HMM: 19-137/151.0
QLPMLCSYFQTLKVKVGLIIDLTNTNRFYDKNELERLTGIKHVKLQCRGHGETPSPDQTQLFINICCRYWDkNPGELIGVHCTHGFNRTGFLIISYLVEk
. |.   . .  . ..  |..|...   .   |. . .||... ... .. ... |. .. ....   . | ...  . |||..| .|||.|.. ||.  
ggpladflellkelgiktivnlrseeergycpeylpelgievlhipildwpdpglplsfdavleflellld.kkngpvlvHCsaGkgRTGtlvalylml.

EDWSIEAAVECFTKCRPPGIY
...|.|.|.| . ..||  ..
lgvsleealeeyrlkrpgvvq
0045450 (Phosphotyrosine protein) phosphatases II 54-169 3.2e-17 58.7 In-house 128-294 (307) alignment 
Range on Protein: 54-169
Range on HMM: 128-294/307.0
LKVKVGLIIDLTNTNR-------------------------FYDKNElerLTGIKHVKLQC--------------------RGHGETPSPDQTQLFINIC
 . .|..|..||..                           ......   | |... .|                       .||  ||....  ||...
weqgvtvivmltelvelgrekcaqywPdegeeltygnftvtllseeh...ldgytvrtlevtdldgtgesrtvthfhytgwpdhgvppsfeelldfieev

CRYWDKN-PGELIGVHCTHGFNRTGFLIISYLVEKED--------WSIEAAVECFTKCRPPGIYKQEYLN
 .. ... .|. . |||..| .||| .|. ||. .          .... ||. . ..|| ..  .|.. 
rkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyr
0039614 (Phosphotyrosine protein) phosphatases II 54-167 1.4e-14 49.7 In-house 122-277 (297) alignment 
Range on Protein: 54-167
Range on HMM: 122-277/297.0
LKVKVGLIIDLTNTNRF--------------------YDKNELErLTGIKHVKLQCR-----------------GHGETPSPDQTQLFINICCRYWDKN-
 . .|  |. ||...                      . ... . | |... .|  .                  ||  ||... . |.... ..  .. 
weqgvtvivmLtklvelgrkcaqywpeeggtygdftvtllkveh.ldgytvrtlevtnngesrtvthfqytgwpdhgvppslellleflelvrealaelp

PGELIGVHCTHGFNRTGFLIISYLV-----EKEDWSIEAAVECFTKCRPPGIYKQEY
.|. . |||..| .||| .|. ||.     .. ..... ||. . ..|| ..   ..
kggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsq
0046846 (Phosphotyrosine protein) phosphatases II 52-163 2.3e-14 49.0 In-house 42-157 (176) alignment 
Range on Protein: 52-163
Range on HMM: 42-157/176.0
QTLKVKVGLIIDLTNTN-----RFYDKNELERLTGIKHVKLQCRGHGETPSpDQTQLFINICCRYWDKNpgELIGVHCTHGFNRTGFLIISYLVEK-EDW
. .. .......||.       ....  ....  ||..  |  . ||  .. .. . ..... .. ...  . . ||| .| .||| |.. ||.|.  ..
mlkelgitavvnlteevelgrlkcpnywpeleklgiqylhlpwpDhgvpdl.elllellefirealkeg..gpvlVHCsaGigRtgtlvaayllelekgl

SIEAAVECFTKCRP-PGIY
|.| |.. . ..||   . 
sveealalvreqRplgavq
0043336 (Phosphotyrosine protein) phosphatases II 54-167 1.1e-13 46.7 In-house 109-265 (278) alignment 
Range on Protein: 54-167
Range on HMM: 109-265/278.0
LKVKVGLIIDLTNTNRF------------------------------------------YDKNElerLTGIKHVKLQCRGHGETPSPDQTQLFINICCRY
 . .|  |..||.   .                                          .|...   .|.  .  |    ||  .|... . |...  ..
welgvttivmLtelvelgrvkcaqYwpggsltygdftvtllkeehlddytvrtlevtnlgdges...rtvthyhylgwpdhgvpeslsllldflkavrea

WDkNPGELIGVHCTHGFNRTGFLIISYLV-----EKEDWSIEAAVECFTKCRPPGIYKQEY
 . .... . |||..| .||| .|. ||.         ...| ||. . ..||  .  ...
le.dsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsq
0045098 (Phosphotyrosine protein) phosphatases II 57-166 1.4e-13 46.3 In-house 88-259 (278) alignment 
Range on Protein: 57-166
Range on HMM: 88-259/278.0
KVGLI--------------------------------------------IDLTNTNRFYDKNELErLTGIKHVKLQCRGHGETPSPDQTQLFINICCRYW
..  |                                            ..|. || .. ...||   |..|... .   ...|| . .. |.... .  
gitvivmltelvelgrekcaqywpeggsltygdftvtllseevlddytlrtllvtnltveredle.srgvthlhylpwpdhgvpslpilksflellefir

DK---------------NPGELIGVHCTHGFNRTGFLIISYLVEKE---DWSIEAAVECFTKCRPP-GIYKQE
.                ..|. . ||| .| .||| |.. ||. .     .... ||. . ..||   .  .|
ealkllaslllsslllldsggpvlVHCsaGvgRtGtlvaaylmlelleggvdlleavkelrsqRpglavqnle
subfamily_CDC14_pd Subfamily CDC14 15-167 5.2e-12 40.2 In-house 174-315 (328) alignment 
Range on Protein: 15-167
Range on HMM: 174-315/328.0
QVIADRFFAFKTPLSSRYddqIPEANRF-QLPMLCSYFQTLKVKvgLIIDLTNTnrFYDKNELERlTGIKHVKLQCRgHGETPSPDQTQLFINICcrywD
 .. |.| |.  | . ..   . .. .  .   | .||.. .|.   .. | .    ||... .  .|..|. |     | |||    . |..|.    .
wivPdkflalagPhnksk...ledgyplhaPeklleyfrknnvt..tvvrLnkk..lYdakkftd.aGfdhkDlffi.DGstPsdaivkkfleia....e

KNPGElIGVHCTHGFNRTGFLIISYLVEKEDWSIEAAVECFTKCRPPGIY--KQEY
|  |. | |||  |. ||| || .||...   . . |.  .  |||  .   .|..
kaeGa.iavhCkaGLGrtGtLiacylmkhyrftaaeaiawlricrPGsvigpqqkf
0051429 (Phosphotyrosine protein) phosphatases II 55-166 5.3e-12 41.5 In-house 43-212 (272) alignment 
Range on Protein: 55-166
Range on HMM: 43-212/272.0
KVKVGLIIDLTNTNRFYDKNELERLTGIKHVKLQCRGHGETPSP---------------------------------------------------DQTQL
. ..  |.||....     .    . ||... | . ......                                                     ..   
elgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseellldyilrellltlllsagearevmhlhytdwpdhgvpqealle

FINICCRywdknpGELIGVHCTHGFNRTGFLIISYLVEkEDWS--------------IEAAVECFTKCRPPGIYKQE
..... .      |. . |||..| .|||...  .|.  ...|              .|.|||   ..||  .  .|
llellld......ggpvlvHCsaGkdRTGtvvalllll.lgvsletivddYlltnlyleeaveelraqrpgavqtee
DSPc Dual specificity phosphatase, catalytic domain 55-171 5.8e-12 40.6 Pfam-A 16-127 (133) alignment 
Range on Protein: 55-171
Range on HMM: 16-127/133.0
KVKVGLIIDLTNTNR--FYDKNELERLTGIKhVKLqcrghgetPSPDQTQLFINICC-----RywdKNPGELIGVHCTHGFNRTGFLIISYLVEKEDWSI
|... |.|..|....  . .|..  . ..|. |.          . .... ... .          .. |. . |||..| .|.. ||| || ... .|.
klgitlvinvtkevpnnnaikkseieylrip.ved........etetkiskeleeavefieka...eqkgkkvlVHCqaGisRSatliiaYlmktknlsl

EAAVECFTKCRpPGIYKQ-EYLNEL
. |.| . . | . | .. ..| .|
neAyefvkerr.skispnagflrqL
DSPc Dual specificity phosphatase, catalytic domain 55-171 5.8e-12 40.6 In-house 16-127 (133) alignment 
Range on Protein: 55-171
Range on HMM: 16-127/133.0
KVKVGLIIDLTNTNR--FYDKNELERLTGIKhVKLqcrghgetPSPDQTQLFINICC-----RywdKNPGELIGVHCTHGFNRTGFLIISYLVEKEDWSI
|... |.|..|....  . .|..  . ..|. |.          . .... ... .          .. |. . |||..| .|.. ||| || ... .|.
klgitlvinvtkevpnnnaikkseieylrip.ved........etetkiskeleeavefieka...eqkgkkvlVHCqaGisRSatliiaYlmktknlsl

EAAVECFTKCRpPGIYKQ-EYLNEL
. |.| . . | . | .. ..| .|
neAyefvkerr.skispnagflrqL
0046845 (Phosphotyrosine protein) phosphatases II 79-166 1.7e-11 39.5 In-house 167-261 (284) alignment 
Range on Protein: 79-166
Range on HMM: 167-261/284.0
LTGIKHVKLQcrGHGETPSPDQTQLFINICCRYWDK-NPGELIGVHCTHGFNRTGFLIISYLVEKE--------DWSIEAAVECFTKCRPPGIYKQE
.| . . .     ||  |||.. . |.... .. .. ..|. | ||| .| .||| .|. .|. .          .... ||  . ..||  .   |
vthfhytswp..dhgvppspedlleflrlvrellenlpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtle
0050432 (Phosphotyrosine protein) phosphatases II 87-165 2.8e-11 38.7 In-house 202-285 (308) alignment 
Range on Protein: 87-165
Range on HMM: 202-285/308.0
LQCRGHGETPSPDQTQLFINICCRYWDKNPGELIGVHCTHGFNRTGFLIISYLV-----EKEDWSIEAAVECFTKCRPPGIYKQ
... .  .   |.... ..... .  ...||. | ||| .| .||| .|. .|.     ..  .... ||  . ..||  .   
fhytnWpdhgvPpspeilldflelvrkslpggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtp
0047943 (Phosphotyrosine protein) phosphatases II 87-167 9.8e-11 37.1 In-house 174-260 (273) alignment 
Range on Protein: 87-167
Range on HMM: 174-260/273.0
LQCRGHGETPSPDQTQLFINICCRYWDKN-PGELIGVHCTHGFNRTGFLIISYLV-----EKEDWSIEAAVECFTKCRPPGIYKQEY
.    ||  ||...   ||... ..  ..  .. . ||| .| .||| .|. .|.     ..  .... ||  . ..|| ...  |.
tgwpdhgvppslesllefielvrkalealpsngpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeq
PTPc_motif_SM00404 57-170 2.9e-10 35.2 In-house 27-133 (140) alignment 
Range on Protein: 57-170
Range on HMM: 27-133/140.0
KVGLIIDLTNTNRFYDKNELERLTGIKhVKLqCRGHGETPSPDQTQLFINICcrywdKNPGELIGVHCTHGFNRTGFLIISYLVEKEDWSIEAAVECFTK
.. ..|..|.. .  ..|.  ..  |. ..   .    ..  |..  ||. .     .. |. . |||..| .|.. ||| || ... .|...|.| . .
githvinvteevsltkensgfqilqip.ldd.nekdklskyldkvldfiena.....ekkggkvlVHCqaGvSRSatliiaYlmryrqlslaeayefvke

CRpPGIYKQ-EYLNE
 | | | .. .....
rR.piispnlnfvrq
0051299 (Phosphotyrosine protein) phosphatases II 87-165 3.3e-10 35.4 In-house 187-272 (288) alignment 
Range on Protein: 87-165
Range on HMM: 187-272/288.0
LQCRGHGETPSPDQTQLFINICCRYWDK--NPGELIGVHCTHGFNRTGFLIISYLV-----EKEDWSIEAAVECFTKCRPPGIYKQ
... .  .   || ..|..... . ...  ..|  . ||| .| .||| .|. .|.     ... .... ||. . ..||  .   
fhytnwpdhgvpdspellldflrlvrkalasgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtp
0036941 (Phosphotyrosine protein) phosphatases II 87-163 6e-10 34.4 In-house 173-261 (297) alignment 
Range on Protein: 87-163
Range on HMM: 173-261/297.0
LQCRGHGETPSPDQTQLFINICCRYWDKN----PGELIGVHCTHGFNRTGFLIISYLV--------EKEDWSIEAAVECFTKCRPPGIY
... |  .   |. .. ..... . ....    .|. . ||| .| .|.| .|. .|.        . . ..|  ||  . ..||  . 
fhytgwpdhgvpespaslldfielvrkvlkllpsggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavq
subfamily_DSP23_pd Subfamily DSP23 77-166 6.3e-09 30.6 In-house 47-133 (148) alignment 
Range on Protein: 77-166
Range on HMM: 47-133/148.0
ERLTGIKHVKLQCRGHgETPSPDQTQLFINICCRYWDKNpgELIGVHCTHGFNRTGFLIISYLVEKEDWSIEAAVECFTKCRPPGIYKQE
|   ..  |.|.   .   |...| . |...     .||  | ..|||  |. ||| ..  ||| ... .   |.    . ||  .   |
eatpnltlvrlriddy.hppaleqvvefvrvveeaeekn..eavsvhcllgrgrtgtmlacylvkerklaaaeaiaevrrlrpgsvetve
0048567 (Phosphotyrosine protein) phosphatases II 99-163 1.1e-08 29.6 In-house 54-123 (157) alignment 
Range on Protein: 99-163
Range on HMM: 54-123/157.0
DQTQLFINICCRYWD--KNPGELIGVHCTHGF---NRTGFLIISYLVEKEDWSIEAAVECFTKCRPPGIY
...  ||..  ....  .. |  | |||..|     ||..|| .||. . ... | |....  .||. ..
ailyrFilklnkflkilelagkaiavhckaglkkrgrtatLigcYlilhlgftpeeaiaplrivrpgsvp
DNA_ligase_A_M ATP dependent DNA ligase domain 286-387 2.9e-08 22.4 Pfam-A 18-121 (202) alignment 
Range on Protein: 286-387
Range on HMM: 18-121/202.0
EKDYRVSWKADGTRyMMLVVGEGQVYLIDRDNAVFSApqfRFPQRKNPREHIF-----DTLIDGEMVF-DKEGDKIHPRYLAYDII-KFQ--VPGKivpG
|... |..| || | . . . ...|.|. |    ..|   ..|.  .  ...|     . ..|||.|  ||| ..| |.    .   | .  |  |    
egafiveeKyDGeR.vqvhkdgdevkllSRrgkdita...kkpellkalkeaflkdvksvildGElvavdketgeilpfqtlasrknkkkvkveek...e

HAPCATCFDVQ
. ..   ||| 
aelsffvFDvl
subfamily_PRL_pd Subfamily PRL 67-163 3e-08 27.8 In-house 42-135 (151) alignment 
Range on Protein: 67-163
Range on HMM: 42-135/151.0
TNRFYDKNELERlTGIKHVKLQCRgHGETPSPDQTQLFINICCRYWDKNPGELIGVHCTHGFNRTGFLIISYLVEKeDWSIEAAVECFTKCRPPGIY
 .  ||...||. .||. . |.    | .|. .  . ..... . . ..|.. ..|||  |. |.  |.   |.|.   . | |||   . |   | 
ceptydteklek.egievldlafd.dGavPpeevveeWlellkekfkeepkstvavhcvaGlGraPvlvalaliea.Gmkyedavefirekrrgain
subfamily_PTPMT1_pd Subfamily PTPMT1 70-166 3e-08 28.3 In-house 62-156 (171) alignment 
Range on Protein: 70-166
Range on HMM: 62-156/171.0
FYDK------NelerltGIKHVKLQCRGHGETPSPDQTQLFINICCRYwdKNPGELIGVHCTHGFNRTGFLIISYLVEKEDWSIEAAVECFTKCRPPGIY
. .       .      |.....|.   . |.|. .. .  ...  ..  .. |. . |||  |  |.. |...||. || .| | |..   |.|.    
lansteewkkl......gveqlqlatvDfteapdleklekgvefiekv..askgkrvYvHCkaGrgRsatlvacylmkkeklspeeAlkalkkkRkiirl

KQE
...
akk
subfamily_PTPDC1_pd Subfamily PTPDC1 119-169 2.3e-07 25.4 In-house 116-166 (182) alignment 
Range on Protein: 119-169
Range on HMM: 116-166/182.0
LIGVHCTHGFNRTGFLIISYLVEKEDWSIEAAVECFTKCRPPGIYKQEYLN
 ..|||  |  ||| || .||| ... . | |..   . ||  |. .| ..
kvavhChaGlGrtGvliacylvyakrltaekaiklvrskrpksiqtreqve
subfamily_DSP12_pd Subfamily DSP12 99-160 4.5e-07 24.4 In-house 69-125 (155) alignment 
Range on Protein: 99-160
Range on HMM: 69-125/155.0
DQTQLFINICCrywdkNPGELIGVHCTHGFNRTGFLIISYLVEKEDWSIEAAVECFTKCRPP
|..  ||. .      . .. . |||. |  |   ..| ||. ||..|.| |..   . .| 
deavdFieeal.....eeegavlvHCqagvSRSvtiviAYlmkkeklslekAlklvkekkpe
SnAC Snf2-ATP coupling, chromatin remodelling complex 186-223 9.2e-07 15.5 Pfam-A 25-62 (74) alignment 
Range on Protein: 186-223
Range on HMM: 25-62/74.0
ELPDWCYEDEGISDKDEEDGEEEDSNNAGPGNRRKKRR
|||.|. |||    ..||...|.. .. | |.|..|..
ELPewikedeeevlekeeeegelevkeygrgkReRkev
subfamily_PTEN_pd Subfamily PTEN 67-158 1.1e-06 23.7 In-house 69-156 (184) alignment 
Range on Protein: 67-158
Range on HMM: 69-156/184.0
TNRFYDKNELerltG--IKHVKLQcrGHgETPSPDQTQLFINICCRYWDKNPGELIGVHCTHGFNRTGFLIISYLVEKEDWSIE-AAVECFTKCR
..| ||....       .......   | ..|. .  . ...   .. .... ... |||  |  ||| ||..||...  .. .  |.|.|.. |
serkydskkf....dgrvavypfd..Dh.nppplelleeivediekwleedkknvvvvHCkaGkGRtGvlivayllkslllekaeealelfaeaR