Gene MTMR1-1 in Nematostella vectensis

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family Myotubularin
Subfamily MTMR1
Protein sequence
ID Type Fasta BLAST phosphatome Note
NvecP024_AA protein Get Run
NvecP024_AA_2-263 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_MTMR1_pd Subfamily MTMR1 18-263 1.8e-111 365.2 In-house 135-387 (389) alignment 
Range on Protein: 18-263
Range on HMM: 135-387/389.0
QGKGTEDTlNRYQGCSLVFLDIPNIHAVRDSLDRLQAVCE-SSSQKKWLSHLESTQWLAYIAAILKGATTIARFVDKG-VSTLVHCSDGWDRTSQLTLLA
.|||.|.. ..|. ..|.||||.|||.||.||..|....  . ..|||||.||||.|| .| .||.||. |.. |..   | |||||||||||.||| ||
kgkgyese.eaYknaelifldihnihvvReslkklkelvlpnvddkkwlsalestkWlehiklilagavkivekvetektsvlvhcsdGWDRtaqltsLa

QLLLDPYYRTFTGFQVLIEKEWISFGHRFRDRLGH---PTCPSQRSPIFLQFLDCVWQVHKQFPSAFQFTANYLLKLADHVNSQWFGNFLYNNVQERHHA
.||||.|||| .||.|||||||.||||.|..||||   ......|||.||||.|||||...|||.||.|....|. |.||..|..||.||.|. .||...
mlllDsyyRtieGfevliekeWlsfGHkfkeRlghgdknssdaersPvFlqfiDcvwqltrqfptAFefneefLitlldhlysclfGtflfnsekervke

FITRTTVSLWSHLNAVKDNYTNSIYQPT---ETLVPVSSLRRLQLWSDYFLRYD
 ....||||||..|. |...||..|...   . |.|. |||||.||..|.||..
kvkektvslwsyvnsskeeftnplyaeelekkvlypkaslrrlelWkeyylrwn
subfamily_MTMR3_pd Subfamily MTMR3 20-260 5.6e-92 301.8 In-house 194-440 (442) alignment 
Range on Protein: 20-260
Range on HMM: 194-440/442.0
KGTEdTLNRYQGCSLVFLDIPNIHAVRDSLDRLQAVCESSS-QKKWLSHLESTQWLAYIAAILKGATTIARFVDK-GVSTLVHCSDGWDRTSQLTLLAQL
 | | . . |. | .|||...|||||| |.. |.|....|  ...|||.||.|.||  .. .|| | ...  ||| | . |||||||||||.|.. ||.|
GGce.leeyypncevvflglanihavrksfnslrallsqspdesnwlsalektkWlqnlsvllkaavkvveavdkegrpvlvhCsdGWdrttqivalakl

LLDPYYRTFTGFQVLIEKEWISFGHRFRDRLGHPTC---PSQRSPIFLQFLDCVWQVHKQFPSAFQFTANYLLKLADHVNSQWFGNFLYNNVQERHHAFI
||||||||  ||.||.|.||..|||.| || ||        .|.|.|||.||.| |...|||..|.|.  .|.||. |  |. || || |. .||..  .
lldpyyrtleGfkvlvereWldfGhkfadrcghgenvddanercPvflqwldavhqlqrqfPtsfefneaflvklvqhtysclfGtflansekereeekv

TRTTVSLWSHLNAVKDNYTNSIYQP--TETLVPVSSLRRLQLWSDYFL
...|.|.|| |.| ...|.| .|..     |.|. |.| |.|||. .|
kertlsvWsllrakekeyrnllykekteavllpavsvrelklwsevyl
subfamily_Dicty-MTMR1-like_pd Subfamily Dicty-MTMR1-like 19-262 5.1e-88 287.9 In-house 145-402 (404) alignment 
Range on Protein: 19-262
Range on HMM: 145-402/404.0
GKGTEDtLNRYQGCSLVFLDIPNIHAVRDSLDRLQAVCESSSQK--KWLSHLESTQWLAYIAAILKGATTIARFVD-KGVSTLVHCSDGWDRTSQLTLLA
|.| || ..||..|.. || | ||| .|.|| .|. ...|. .|  .|||.|||..||  |  .|.|...|.. .. .. | ||||||||||||||. |.
gagyed.isryenceieflnienihelreslkklkkavnsiiekeknwlselessrWldhiklllegskriveliekekssvlvhcsdgwDrtsqlssls

QLLLDPYYRTFTGFQVLIEKEWISFGHRFRDRLGH--PTCPSQRSPIFLQFLDCVWQVHKQFPSAFQFTANYLLKLADHVNSQWFGNFLYNNVQERHHAF
||||||||||..||.|||||||.|||| | .| |.   .  ..||||||||.|||.|. ||||. |.| ...|.|. |...|  ||.|||.. .||... 
qllldpyyrtiegFivliekewlsfGhkfaqRigqttekssdersPiflqFidcvyqltkqfptsFeFnekflikildalyscrfgtFLydsekeRqqnn

ITRTTVSLWSHLNAVKDNYTNSIY-----QPTETLVPVS-----SLRRLQLWSDYFLRY
..  |||||. |.| |..| |..|     . .|.    .     ......|||.|.||.
laketvslWalleankseylnplyilekkeqkenitssessssadikliklWseyylrw
0040695 (Phosphotyrosine protein) phosphatases II 18-262 1.6e-87 287.6 In-house 135-385 (388) alignment 
Range on Protein: 18-262
Range on HMM: 135-385/388.0
QGKGTeDTLNRYQGCSLVFLDIPNIHAVRDSLDRLQAVCESS-SQKKWLSHLESTQWLAYIAAILKGATTIARFVDKGVS-TLVHCSDGWDRTSQLTLLA
.|.|. .  ..|. . |.||.||||| ||.|| .|. .| .. .  ..|| ||...|| .|  ||..| .|.. .|.| |  ||||||||||||||. ||
lgggv.enedaypnaeliflnipnihvvreslqklldaclnvpdslnllslleesgwldliklilelavlivklldlgnssvlvhcsdgwdrtsqlssLa

QLLLDPYYRTFTGFQVLIEKEWISFGHRFRDRLGH---PTCPSQRSPIFLQFLDCVWQVHKQFPSAFQFTANYLLKLADHVNSQWFGNFLYNNVQERHHA
||||||||||. ||||||||||.||||.| |||||    ......||.||.|||||||...|||.||.|. ..|| ||||. | .||.||.|. .||  .
qllldPyYRTleGFqvLiekeWlsfghkfadRlghleseidskefsPvFllFLdcvwqLlrqfPtaFeFnerlLlfLadhlyscrfgtFlfnsekerlel

FITRTTVSLWSHLNAVKDNYTNSIYQPTET--LVPVSSLRRLQLWSDYFLRY
 . . |.||||.|.  |. ..| .|.|...  |.|..|.. |.||..|.||.
svsertlslwsyllsrkseflnplYdpsslevllpslsvldlllWleyylrw
subfamily_MTMR6_pd Subfamily MTMR6 17-263 1.8e-85 279.6 In-house 144-396 (397) alignment 
Range on Protein: 17-263
Range on HMM: 144-396/397.0
VQGKGTEDTlNRYQGCSLVFLDIPNIHAVRDSLDRLQAVCESSS--QKKWLSHLESTQWLAYIAAILKGATTIARFV-DKGVSTLVHCSDGWDRTSQLTL
..||| |.. . |. . . |..| ||| .|.|| .|  |.| .|  ....|| |||..|| .| |.|. .. ||. | ..|.| |||||||||||.| . 
aagkGyene.dnysnikfqfvgienihvmreslqkllevvelksksvseflsglessgwlkhikavldasifiakavaeegasvlvhcsdGwdrtaqvcs

LAQLLLDPYYRTFTGFQVLIEKEWISFGHRFRDRLGHPTC-PSQRSPIFLQFLDCVWQVHKQFPSAFQFTANYLLKLADHVNSQWFGNFLYNNVQERHHA
||.|||||||||. ||.|||||||.||||.| .| |.    . . ||||.|||.||||. .||| ||.|  ..||.| ||| |  ||.|| |. ..|...
lasllldpyyrtikGflvliekewlsfGhkfsercGlldedskevsPiftqflecvwqlleqfpkafefnerfllelhdhvyscqfGtflgncekdrrdl

FITRTTVSLWSHLNAVKDNYTNSIYQPTET---LVPVSSLRRLQLWSDYFLRYD
 ... | |||..| . ||.|.| .|.....   | |  .  .|.||.  . |.|
klkertkslwayllerkddylnplykaetekevlkpdtapaalklwralynrfd
Myotub-related Myotubularin-like phosphatase domain 18-210 2.9e-79 259.4 Pfam-A 152-351 (353) alignment
Myotub-related Myotubularin-like phosphatase domain 18-210 2.9e-79 259.4 In-house 152-351 (353) alignment
subfamily_Ank-MTMR1_pd Subfamily Ank-MTMR1 18-262 3.9e-70 228.7 In-house 149-404 (405) alignment 
Range on Protein: 18-262
Range on HMM: 149-404/405.0
QGKGTEDtLNRYQGCSLVFLDIPNIHAVRDSLDRLQAVCESSSQK---------KWLSHLESTQWLAYIAAILKGATTIARFVDKGVSTLVHCSDGWDRT
.| | |. .  |  | |||..||||| .| ||..| .  .||..          ..   .| | |...| .||. ||  | .. || | |||||||||||
ngagfen.ihnypncklvfmnipnihvirksleklvlamkssardkdhtestdmrfwgyieetgwishiksileaatfsaelilkgnsilvhcsdgwdrt

SQLTLLAQLLLDPYYRTFTGFQVLIEKEWISFGHRFRDRLGH-PTCPSQRSPIFLQFLDCVWQVHKQFPSAFQFTANYLLKLADHVNSQWFGNFLYNNVQ
 |.| |.|.|||||||| .||||||||||.||||.|  |||| |    .||||| |||||..|. .|||  |.|| . || ..| . |  .| || |  .
pqitsltqilldpyyrtivgfqvliekewlsfghkfslrlghlpgneeerspifqqfldccfqllsqfpllfeftpslllfisdnihsckygtflnncek

ERHHAFITRTTVSLWSHLNAVKDNYTNSIYQPTE--TLVPVSSLRRLQLWSDYFLRY
.| .  .   |.|.|| .|   ... |  |.| .  .. |    | |.||   ..|.
drvqdqvktktisiwsevnlnvnkflnpyynpqdiqsikpklysrclelwkacymrv
subfamily_MTMR9_pd Subfamily MTMR9 19-262 9.2e-62 201.3 In-house 140-392 (393) alignment 
Range on Protein: 19-262
Range on HMM: 140-392/393.0
GKGTEDTlNRYQGCSLVFLDIPNIHAVRDSLDRLQAVCES--SSQKKWLSHLESTQWLAYIAAILKGATTIARFVDK-GVSTLVHCSDGWDRTSQLTLLA
| | | . ..|.  . .  .. ... . ||| .|  .|.    |..|.||.||...||  .|..|. |...|  .|. |.. .|| ..| | | |.| ||
gggiete.vkysqwkkasrslesvasiqdslaklleacsdaglstdkflsrleksgwlsqvadlleaalvvaqcldeegapvvvhgeeGlDatlqvtsLa

QLLLDPYYRTFTGFQVLIEKEWISFGHRFRDRLGHPTCPS----QRSPIFLQFLDCVWQVHKQFPSAFQFTANYLLKLADHVNSQWFGNFLYNNVQERHH
||.|||..||  ||. |||.|||  || |  |  . .  .    ...|.|| |||||.|. .||| .| | ...|  |  |  |  ||.||..| .||..
qlildpdaRtvrgfealiereWiqaGHPFasRaskvaaketkkklsgpvfllFLDcvyqilsqfpasFEFneelLillfehsyssqfgtflcdneaerke

AFITRTTVSLWSHLNA--VKDNYTNSIYQPTET-LVPVSSLRRLQLWSDYFLRY
. ... ||||||..|.  . ....| .|..... ..|   .  |.|||. .||.
lklkkktvslwsyvnrpeklkqflnplyeanaeviwpsvapqslelWselylrw
subfamily_MTMR5_pd Subfamily MTMR5 27-260 8.9e-58 188.2 In-house 223-479 (483) alignment 
Range on Protein: 27-260
Range on HMM: 223-479/483.0
NRYQGCSLVFLDIPNIHAVRDSLDRLQAVCESSSQ------KKWLSHLESTQWLAYIAAILKGATTIARFVD-KGVSTLVHCSDGWDRTSQLTLLAQLLL
. .. . .. .....| .|. |. .|  .| .| .      . .|. .|  .||  | ..|. .....  .| .| | ||   |||| |.|.. ||||||
evdskaefipvelveirqvkasfkkllraClpstaveeaesqsFlksvedseWlqqissllqlsgavvdlldlqgssvlvslEdGwdvtaqvsslaqlll

DPYYRTFTGFQVLIEKEWISFGHRFRDRLGH-PTCPS-QRSPIFLQFLDCVWQVHKQFPSAFQFTANYLLKLADHVNSQWFGNFLYNNVQERHHAFI---
||||||. ||.||.||||..||||| .|  . ... |   .|.||||||||.||..||| || |   ||  || |  |. |  ||..  .|| .. .   
dpyYRtleGFkvLveKEWLafGHrFtkrsnqtlsaqssgfaPvFlqFLDcvhqvsrqfPlafefndfylkflayhsvsnrfrtfllDseyerlesgllye

-------TRTTVSLWSHLNAVKD---NYTNSIYQP--TETLVPVSSLRRLQLWsDYFL
        ....|.| .... .     . | .|.|  .|.| | |..  |..| ||.|
ekaekrakkagksvwdyidrqhkrspifynflyspdesevlrPssnvsslkvW.dyyl
subfamily_MTMR10_pd Subfamily MTMR10 38-231 7.5e-53 171.6 In-house 122-328 (380) alignment 
Range on Protein: 38-231
Range on HMM: 122-328/380.0
DIPNIHAVRDSLDRLQAVCESSSQK-------KWLSHLESTQWLAYIAAILKGATTIARFV-DKGVSTLVHCSDGWDRTSQLTLLAQLLLDPYYRTFTGF
..|.|. |  . ..|...|  .. .       |||| ||.|.||||. ..|. |. ... | .|. | ..  |.| |    .  ||||.|||.||| .||
elpsiqdvqkaylklreLcvidtseefvtlddkwlssLektrWLayvrlclstasdavktvvekkrsvilqesegrDlscvvaSLaqlmldphyrtisGf

QVLIEKEWISFGHRFRDRLGHPTCPSQ-RSPIFLQFLDCVWQVHKQFPSAFQFTANYLLKLADHVNSQWFGNFLYNNVQERHHAFITRTTVSL----WSH
| ||.|||.. || | ||||| .  .. .||.|| |||||.| ..||||.|.||  .|..| |...|  |..|| |. ..|  |   .. . .    . .
qsliqkewvaaghpfldrlghikpseksespvfllFldcvdqlleqfpseFeFtetfLialwdsshsgifltflfnseeqrlkavvsssplliakselke

LNAVKDN
 .  ||.
ndllkde
subfamily_pats1_pd Subfamily pats1 29-151 7.3e-28 89.3 In-house 333-460 (691) alignment 
Range on Protein: 29-151
Range on HMM: 333-460/691.0
YQGCSLVFLDIPNIHAVRDSLDRLQA--VCESSSQKKWLShLESTQWLAYIAAILKGATTIARFVDKGVSTLVH-CSDGWDRTSQL---TLLAQLLLDPY
 ... ..||..|  . |..   .|    .   .|...| . .|  .|.  .  .|..|  .. ..|.| | |..  .|. . . .|   . |||.|.||.
missniiflslPtrekveerffdllqsilsldgsddewke.ieeskwvdsvkllleaavkvsnlldeGssvllknsidsPlieldlasisslaqvlsdPf

YRTFTGFQVLIEKEWISFGHRFRDRLGHP
|||. ||.|||||||.|.|. | ..  | 
yrtldGfkvliekewlsyGfPfskinyhk
subfamily_pats1_pd Subfamily pats1 158-242 5.7e-24 76.5 In-house 553-637 (691) alignment 
Range on Protein: 158-242
Range on HMM: 553-637/691.0
SPIFLQFLDCVWQVHKQFPSAFQFTANYLLKLADHVNSQWFGNFLYNNVQERHHAFITRTTVSLWSHLNAVKDNYTNSIYQPTET
||||.|||| |||..|.||  |.|   .|| | ... |  ||||||.. ...    . . . |.||  |  | ...| .|... .
sPifvqfldlvwqlqkefPfhfefneslllllvkesfssrfGnflyseakrdserkvlkrsksiwsfinqnksrfinllykhsas
PTPc_DSPc_SM00012 86-190 2.8e-12 42.1 In-house 38-101 (105) alignment 
Range on Protein: 86-190
Range on HMM: 38-101/105.0
TiarfvdkGVSTLVHCSDGWDRTSQLTLLAQLLLDPYYRTftgfqvliekewisfghrfrdrlghptcpsqrspIFLQFLDCVWQVHKQFPSAFQFTANY
.       . ...||||.|..|| ....|. || . ...|                                   .......|... || |...|. ..|
s.......skpvvVhCsaGvgRtgtfvaldillqqleket..................................kevdifqivkelrkqRpgmvqteeqy

LLKLA
|  ..
lflyr
0051429 (Phosphotyrosine protein) phosphatases II 36-156 6.6e-07 24.8 In-house 74-177 (272) alignment 
Range on Protein: 36-156
Range on HMM: 74-177/272.0
FLDIPNIHAVRDSLDRLQAVCE-------------------SSSQKKWLSHLESTQWLAYIAAIlKGATTIARFVDKGVSTLVHCSDGWDRTSQLTLLAQ
.|.|.. .| . .. .|   .                    | ..  .. ||  |.|. . ..  .   .. ... .|   ||||| |.|||  . .|  
hlpilddsaptilygalrvtllseellldyilrellltlllsagearevmhlhytdwpdhgvpq.eallellellldggpvlvHCsaGkdRTGtvvalll

LLLDpyyrtftgfqvliekewisfghrfrdrlghptcpsQ
|||.                                    
lllg...................................v
0049772 (Phosphotyrosine protein) phosphatases II 32-119 2.9e-06 22.7 In-house 156-237 (314) alignment 
Range on Protein: 32-119
Range on HMM: 156-237/314.0
CSLVFLDIPNIHavrdsldrlQAVCESSSQKKWLSHLESTQWLAYIAAILKGATTIARFVD---KGVSTLVHCSDGWDRTSQLTLLAQLLL
. ... |.....         . ... .  ...  ..  . .  . | .|.    . .|..   ||  .||||..|..||  . ..| |..
neptaadlellk.........eelydpelferlgikylripvpDgsaplledfdeflefieeadkggpvlvHCkaGkgRtgtfvvaaylmk
subfamily_MTMR14_pd Subfamily MTMR14 92-149 5.6e-06 17.4 In-house 266-329 (357) alignment 
Range on Protein: 92-149
Range on HMM: 266-329/357.0
DKGVSTLVHCSDGWDRTSQLTLLAQLLLDP---YYRTFTGFQV---LIEKEWISFGHRFRDRLG
|.   .||||  |||||   . | .| |      .....  ..    .  .|  |||.. ||| 
dedsGllvhcisGWdrtPlfvsllrlslWadglihqslsaaellyltvaydWflfghqlpdrlk
0045098 (Phosphotyrosine protein) phosphatases II 71-119 7e-06 21.1 In-house 176-231 (278) alignment 
Range on Protein: 71-119
Range on HMM: 176-231/278.0
TQWLAYIAAILKGATTIARF-------VDKGVSTLVHCSDGWDRTSQLTLLAQLLL
...| ..  |..   ..|..        |.|  .||||| |..||  | ..  .| 
ksflellefirealkllaslllsslllldsggpvlVHCsaGvgRtGtlvaaylmle