Gene MTMR14 in Nematostella vectensis

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family Myotubularin
Subfamily MTMR14
Protein sequence
ID Type Fasta BLAST phosphatome Note
NvecP028_AA protein Get Run
NvecP028_AA_221-384 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_MTMR14_pd Subfamily MTMR14 28-385 1.4e-171 562.2 In-house 1-352 (357) alignment 
Range on Protein: 28-385
Range on HMM: 1-352/357.0
KKCLNYFAKDYRFSVISNANGELCGHYPVKIVILETRLDAGSGGGTILIYCVFSVndsTRLRELFTKARFARCRSRFVVPVILYDDKNICRSATLSSAAE
||... ...||..|||.|.|||||..||||..|||..|..|| | . |......|   .|||||.|||..||||.||||||||.|.||||||||||.|||
kkveellkrdyslsvidntnGelcsrypvkllileyelgegsegekelvesaydv...qrlrelltkakyarcrerfvvpvilldgknicrsatlsvaae

IYGRFGYDFLFSGT-SSAWDLFVVSELFCNHLcisCSNDWAIFDRIRGHDIQLLKELKVDCICDLMVEKKKVKFGMNVTSSEKVDKSQRYSDFCLCCVPY
||||.|...|.||. ....|   .... ...    .....|..||.|..||.|||.|||..|.||||||||||.|..|.||||.||..||.||.|...||
iygrsGlnylasggeeadadkedeelitaked...qaeeqalldrvrksdikllktlkvklivdlmvekkkvkyglavsssekadkekrykdftllslPy

PGCEFFRDFKTKGYSADGLYFNWKQDYVDAQFTVPETLAYRLGIEWHLYKAssWDLILLTQNYLLLLLNSIM-DGEGGTLIHCISGWDRTPLFVSLLRLS
||.|||..|... |||. |..|||||.|||....|..||....|.|. ||.  |||. |||||| |||.... |...|.|.|||||||||||||||||||
PGveffkkfrdnkysaknlfynWkqdevdaelniPdklaasvdidwseykk..WdlvaltqnylklllkyvkededsGllvhcisGWdrtPlfvsllrls

LWADRKVHASLSASEILYLTIAYDWFLFGHDLPDRIQKGEEVFHFCFNFLKYIGSDTFSI
||||...|.||||.|.||||.|||||||||.||||..||||...|||..||.| |..|||
lWadglihqslsaaellyltvaydWflfghqlpdrlkkgeeilffcfdvlkfitseefsi
0040695 (Phosphotyrosine protein) phosphatases II 33-384 3.1e-44 145.2 In-house 21-316 (388) alignment 
Range on Protein: 33-384
Range on HMM: 21-316/388.0
YFAKDYRFSVISNANGELCGHYPVKIViletrldagsgggtiliycvfsVNDSTRLRelfTKARFARCRSRFVVPVILY----DDKNICRSATLSSaaei
 .  |. . .| | |.|||..|| ..|                      |  |   .   . .|.||.||.. .||..|    ... ..||... .    
glgldlwrisivNenyelcpsYPallv......................VPksisde...llkrvarfrskgriPvlsyrhpnngavllRssqplv....

ygrfgydflfsgtssawdlfvvselfcnhlcISCSNDWAIFDRIRGHDIQLLKELKVDCICDLMvekKKVKFGMNVTSSEKVDKSQRYSDFCLCCVPYPG
                                 . ...  ..........||..|.. .|.||.   .|... .|......|.. ..|... | ....|.
...............................glllsrsledeklleailkllpnlskllivdlr...pklnalanralgggvenedaypnaeliflnipn

CEFFRDfktkgysadglyfnWKQDYVDAQFTVPETLayrlGIEWHLYKASSWDLILLTQNYLLLLLNSIMDGEGGTLIHCISGWDRTPLFVSLLRLSLWA
....|.              . |...|| . ||..|     . . | . . .||| |..... |... . .|. . |.||..|||||....||..|.|..
ihvvre..............slqklldaclnvpdsl....nllslleesgwldliklilelavlivklldlgnssvlvhcsdgwdrtsqlssLaqllldP

DrkvHASLSASEILyltIAYDWFLFGHDLPDRIQKGEE---------------------------VFHFCFNFLKYIGSDTFS
.   . .|    .|   |...|..||| ..||.  .|.                           .| |....|...   ..|
y...YRTleGFqvL...iekeWlsfghkfadRlghleseidskefsPvFllFLdcvwqLlrqfPtaFeFnerlLlfLadhlys
0051429 (Phosphotyrosine protein) phosphatases II 175-331 1.6e-10 36.6 In-house 36-180 (272) alignment 
Range on Protein: 175-331
Range on HMM: 36-180/272.0
HDIQLLKELKVDCICDLMVEKKK--VKFGMNVtssekvdksqrySDFCLCCVPYPGCEFFRDFkTKGYSADGLYFNWKQDYVDAQFTVPETLAYRLGIEW
.|.. ||||....|.||. |  .  .|. .               .. ....|... .... .    ..   |.. .. ||.   ...  .| .  . |.
adfwrlkelgiktivdLrseeErgrlkcdryw............pgirylhlpilddsaptil.ygalrvtllseellldyilrellltlllsagearev

HLYKASSWDLILLTQNYLLLLLNSIMDgEGGTLIHCISGWDRTPLFVSLLRLSLWADRK
...   .|      |..|| ||. . | .|  |.|| .|.||| ..| ||.| |  .. 
mhlhytdwpdhgvpqeallellellld.ggpvlvHCsaGkdRTGtvvallllllgvsle
0051082 (Phosphotyrosine protein) phosphatases II 173-325 3e-09 32.1 In-house 22-116 (151) alignment 
Range on Protein: 173-325
Range on HMM: 22-116/151.0
RGHDIQLLKELKVDCICDLMVEKKKVKFGMNVTSSEkvdksqrysdfclccvpypgceffrdfktkgysadglyfnwkqdyvdaqftvpetlayrlgIEW
  ....|||||....|..|. |.   ..   ... .                                                             ||.
ladflellkelgiktivnlrseeergycpeylpelg.............................................................iev

HLYKASSWDLI--LLTQNYLLLLLNSIMDG-EGGTLIHCISGWDRTPLFVSLLRLS
. .   .|.     |... .| .|. ..|  .| .|.|| .|..|| ..| |... 
lhipildwpdpglplsfdavleflellldkkngpvlvHCsaGkgRTGtlvalylml
subfamily_MTMR3_pd Subfamily MTMR3 301-367 1.3e-08 27.1 In-house 269-329 (442) alignment 
Range on Protein: 301-367
Range on HMM: 269-329/442.0
EGGTLIHCISGWDRTPLFVSLLRLSLwaDrKVHASLSASEILyltIAYDWFLFGHDLPDRIQKGEEV
.   |.||  |||||.  |.| .| |  | . . .|   ..|   .  .|. ||| . ||.  ||.|
grpvlvhCsdGWdrttqivalaklll..d.pyyrtleGfkvl...vereWldfGhkfadrcghgenv
0043147 (Phosphotyrosine protein) phosphatases II 173-324 1e-07 27.4 In-house 33-123 (172) alignment 
Range on Protein: 173-324
Range on HMM: 33-123/172.0
RGHDIQLLKELKVDCICDLMvEKkkvkfgmnvtssekvdksqrysdfclccvpypgceffrdfktkgysadglyfnwkqdyvdaqfTVPETLAYRLGIEW
  .....||||....| .|. |                                                                ... .| .||||..
ladfwrmlkelgithivnlt.el...............................................................lydpellerlgiqy

HLYKASSWDLIllTQNYLLLLLNSIMD-----GEGGTLIHCISGWDRTPLFVSLLRL
. .     .    . ..|| .|. | .      .| .|.||  |..||...| .. .
lylpwpDhgvp..llellleflefidellalspggpvlVHCsaGvgRtgtlvaaylm
0044763 (Phosphotyrosine protein) phosphatases II 174-321 1e-07 27.3 In-house 38-130 (178) alignment 
Range on Protein: 174-321
Range on HMM: 38-130/178.0
GHDIQLLKELKVDCICDLMVEKKKVKFGMNVTSSEKVDksqrysdfclccvpypgceffrdfktkgysadglyfnwkqdyvdaqftvpetlayrlgieWH
 .|..|||||....|..|  |.   .....    |. .                                                            ..
addlellkelgithivnlteelelgflkcdpywpeeag............................................................iq

LYKASSWDLILLT-QNYLLLLLNSIM----DGEGGTLIHCISGWDRTPLFVSL
 ..    |    .   ..| ... |     . .| .|.||  |..|....| .
ylhipipDhgvpdllehflefvefieealdekggpvlVHCsaGvgRsgtlvaa
subfamily_MTMR1_pd Subfamily MTMR1 300-366 1.2e-07 23.4 In-house 211-271 (389) alignment 
Range on Protein: 300-366
Range on HMM: 211-271/389.0
GEGGTLIHCISGWDRTPLFVSLLRLSLwaDRkVHASLSASEILyltIAYDWFLFGHDLPDRIQKGEE
 .   |.||  |||||  ..||  | |  |   . ...  |.|   |. .|  ||| . .|. .|..
ektsvlvhcsdGWDRtaqltsLamlll..Ds.yyRtieGfevl...iekeWlsfGHkfkeRlghgdk
0045098 (Phosphotyrosine protein) phosphatases II 173-326 2e-07 26.2 In-house 77-231 (278) alignment 
Range on Protein: 173-326
Range on HMM: 77-231/278.0
RGHDIQLLKELKVDCICDLM--VEKKKVKFGMNVTSsekvDKSQRYSDFCLCCVPYpgceffrdfktkgysadglyfNWKQDYVDAQFTVPE-----TLA
  .....|.||.. .|. |.  ||....|. .   .    ..|..| ||..... .                      . .||.   ..|       .  
vadfwrmlwelgitvivmltelvelgrekcaqywpe....ggsltygdftvtllse.....................evlddytlrtllvtnltveredl

YRLGIEWHLYK------ASSWDLILLTQNYLLLLLNSI-------------MDGEGGTLIHCISGWDRTPLFVSLLRLSL
. .|.... |.      . | ...   ...|  ... .             .|..| .|.||  |..||  .| .  .  
esrgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsggpvlVHCsaGvgRtGtlvaaylmle
0041856 (Phosphotyrosine protein) phosphatases II 174-322 1.1e-06 23.9 In-house 48-130 (182) alignment 
Range on Protein: 174-322
Range on HMM: 48-130/182.0
GHDIQLLKELKVDCICDLMvekkkvkfgmnvtssekvdksqrysdfclcCVPYPGceffrdfktkgysadglyfnwkqdyvdaqftvpeTLAYRLGIEWH
 .....||||.. .| .|                               ...|.                                   .| .||||...
adflrmlkelgittivnlt..............................eelywp..................................ellerlgiqyl

LYKASSWDLILltQNYLLLLLNSIMDGEGGTLIHCISGWDRTPLFVSLL
 .    ..      . || ... . . .| .|.||  | .||. .| . 
ylpwpDhgvpd..ldelldfieevleeggpvlVHCsaGvgRtgtlvaay
subfamily_Dicty-MTMR1-like_pd Subfamily Dicty-MTMR1-like 290-363 1.1e-06 20.1 In-house 211-278 (404) alignment 
Range on Protein: 290-363
Range on HMM: 211-278/404.0
LLLLLNSIMDGEGGTLIHCISGWDRTPLFVSLLRLSLwaDRkVHASLSASEILyltIAYDWFLFGHDLPDRIQK
   ....| . .   |.||. |||||.  .|| .| |  |   .  ... ..|   |  .|  |||   .||..
skriveliekekssvlvhcsdgwDrtsqlsslsqlll..dp.yyrtiegFivl...iekewlsfGhkfaqRigq
0042113 (Phosphotyrosine protein) phosphatases II 175-325 1.3e-06 23.5 In-house 67-200 (245) alignment 
Range on Protein: 175-325
Range on HMM: 67-200/245.0
HDIQLLKELKVDCICDLMVEKKK--VKfgmnvtssekvdksqrysdfCLCCVPYPGCEFFRDFKTKGYSADGlyfnwKQDYVDAQFTVP--ETLAYRLGI
. ...|.||.. .|..|. |  .  ||                    |    |  .   . ||. .  | .      ..||.  ...|    .  .| .|
dfwrmlwelgittivmLteeeelgrvk....................caqywplgesltygdftvtllseeh.....lddytvrtlevtnlgddesrevi

EWHLYKASswDLILLT-QNYLLLLLNSIMD-----GEGGTLIHCISGWDRTPLFVSLLRLS
 .| .     |    .  ..|| .|. . .     ..| .|.||  | .|| .|. .... 
hyhylpwp..dhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylml
0049772 (Phosphotyrosine protein) phosphatases II 250-328 1.5e-06 23.7 In-house 167-241 (314) alignment 
Range on Protein: 250-328
Range on HMM: 167-241/314.0
KqdyvdaqfTVP--ETLAYRLGIEWHLYKASSWDLIllTQNYLLLLLNSIMD--GEGGTLIHCISGWDRTP--LFVSLLRLSLWA
|        ..     |  ||||... .  . ..    . .... .|. | .   .| .|.|| .|..||.  ... .| . |. 
k........eelydpelferlgikylripvpDgsap..lledfdeflefieeadkggpvlvHCkaGkgRtgtfvvaaylmkllgv
0048179 (Phosphotyrosine protein) phosphatases II 174-324 2.2e-06 23.0 In-house 19-106 (144) alignment 
Range on Protein: 174-324
Range on HMM: 19-106/144.0
GHDIQLLKELKVDCICDLMVEKKKVKFGMNvtssekvdksqrysdfclccvpypgceffrdfktkgysadglyfnwkqdyvdaqftvpetlayrlGIEWH
 .|..|||.|.......|. |  .  .. .                                                                 ||...
aldlellkklgittvinlteeyepeflere.................................................................giqyl

LYKASSWDLILLTqNYLLLL---LNSIMDGEGGTLIHCISGWDRTPLFVSLLRL
 .    ..   |. ..|| .   ...... .| .|.||  | .||...| . ..
hlpwpDhgvpdll.ellleflefieealeeggpvlVHCsaGvgRtgtlvaaylm
Myotub-related Myotubularin-like phosphatase domain 292-364 2.7e-06 19.4 Pfam-A 222-288 (353) alignment
Myotub-related Myotubularin-like phosphatase domain 292-364 2.7e-06 19.4 In-house 222-288 (353) alignment
0037934 (Phosphotyrosine protein) phosphatases II 175-328 3.2e-06 22.4 In-house 63-205 (243) alignment 
Range on Protein: 175-328
Range on HMM: 63-205/243.0
HDIQLLKELKVDCICDLMVEKKKVKFgmnvtssekvdksqrysdfcLCCVPYPgceffRDFKTKGYSADGLYFNWKQDYVDAQFTVPE---TLAYRLGIE
.....|.||....|..|. .. . ..                     |.  .|      ..  ....   | .....||.   ...     .  .||.| 
sfwrmlwelgitvivmltelvElgre....................kcaqywp.....gevtygdftvtllseehlddytvrtlllenldlddltrlvih

WHLYKASS------WDLILLTQNYLLLLLNS-----IMDGEGGTLIHCISGWDRTPLFVSLLRLSLWA
.| .           . .|   ...   ...       |..| .|.||  | .|| ... .. . |  
yhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRtGtliaaylmllll
0040439 (Phosphotyrosine protein) phosphatases II 174-324 4.6e-06 21.9 In-house 68-202 (249) alignment 
Range on Protein: 174-324
Range on HMM: 68-202/249.0
GHDIQLLKELKVDCICDLMVEKKK--VKfgmnvtssekvdksqrysdfCLCCVPYPGCEFFRDFKTKGYSADGlyfnwKQDYVDAQFTVPE-TLAYRLGI
......|.||.. .|..|. .. .  .|                    |    |  |   . ||. .  | .      |.||.  ....        . .
edfwrmlwelgitvivmLtslvelgrek....................caqywplggsleygdftvtllsvev.....kddytvrtleltnlydgesrtv

EWHLYKASSWDLILLTQNYLLLLLNSIMD------GEGGTLIHCISGWDRTPLFVSLLRL
 .  |     . .  . . || ... ...       .| .|.||  | .||..|. .. .
lhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaaylm
subfamily_MTMR6_pd Subfamily MTMR6 292-361 5e-06 18.0 In-house 214-277 (397) alignment 
Range on Protein: 292-361
Range on HMM: 214-277/397.0
LLLNSIMDGEGGTLIHCISGWDRTPLFVSLLRLSLwaDrKVHASLSASEILyltIAYDWFLFGHDLPDRI
.. ..... .   |.||  |||||   .||  | |  | . . ..    .|   |  .|. ||| . .| 
fiakavaeegasvlvhcsdGwdrtaqvcslaslll..d.pyyrtikGflvl...iekewlsfGhkfserc
0049260 (Phosphotyrosine protein) phosphatases II 175-323 6.7e-06 21.4 In-house 24-111 (152) alignment 
Range on Protein: 175-323
Range on HMM: 24-111/152.0
HDIQLLKELKVDCICDLMVEKKK----VKFGMnvtssekvdksqrysdfclccvpypgceffrdfktkgysadglyfnwkqdyvdaqftvpetlayrlgi
.....||||....|  |. .  .    .....                                                                    
dfwrmlkelgittivmltellelgklkceqyi....................................................................

ewHLYKASSWD-----LILLTQNYLLLLLNSIMDGEGGTLIHCISGWDRTPLFVSLLR
  . .     |     |. | .  ||..   . | .| .|.||  | .||...| .. 
..qylhlpwpDhgvpdlsqlllflllfieklaldkggpvlVHCsaGvgRtgtlvaayl
0048076 (Phosphotyrosine protein) phosphatases II 176-324 9.2e-06 20.9 In-house 21-104 (145) alignment 
Range on Protein: 176-324
Range on HMM: 21-104/145.0
DIQLLKELKVDCICDLmvekkkvkfgmnvtssekvdksqrysdfclccvpypgceffrdfktkgysadglyfnwkqdyvdaqfTVPETLAYRLGIEWHLY
|..|||.|.. .. .|                                                                   |  ..| .||||... .
dlellkdlgittvlnl...................................................................tselellerlgiqylyl

KASSWDLILLTQN--YLLLLLNSIMDGEGGTLIHCISGWDRTPLFVSLLRL
    ..   |..    .| ....... .| .|.||  | .||...| .  .
pwpDhgvpdllellleflefieealkeggpvlVHCsaGvgRtgtlvaaylm