Gene MTMR3 in Nematostella vectensis

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family Myotubularin
Subfamily MTMR3
Protein sequence
ID Type Fasta BLAST phosphatome Note
NvecP029_AA protein Get Run
NvecP029_AA_147-551 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_MTMR3_pd Subfamily MTMR3 130-547 1.1e-214 706.2 In-house 1-418 (442) alignment 
Range on Protein: 130-547
Range on HMM: 1-418/442.0
AHYAWSMAS----PNSFTSQDASATPYSFLEEVHRMGFEtgVDSPWRISDANSSFEVCRTYPRLHVIPSSISDSDLAKVASFRCSGRFPSIVWRHMTNGA
|..||....    ...|....||.. ... |||.|.||.  ... |||||.||.|..|..||. ...|.||.|.||.||||||...|.|..||||..|||
ayhawkleeeekerdgfllraasvaeeklkeeverlGfd..lkeawrisdvnsdfklCssyPkklivPksitdddlkkvasfrslkrlPavvwrhkknga

VIARCSQPQVGWLGWRSAEDELLLQAIGQACTSDRYPsvaKLLNGITVNGINKKHDMGDVLNGPADMSEDGPIARNPKQVLIVDARSYTAAYANRGKGGG
|.||||||.|||||||.|||| ||.|| .||..|...   |  .....||..||.|..|.|.. ||.||.  .|...|..|||||||||||.|||.||||
vlarcsqPevgwlgWrnaedekllkaiakacaldage...kakgeklsngkakkkdvsdaldaeadaseeeslaeekkkllivdarsytaafanrakgGG

FEYTEYYPNCEVMFMNLANIHGIRRSFHSLRALCSGSYDVPNWWSLIEKTNWLHHISMLIKSAVTIVHAVHTDGRPVVVHCSDGWDRTTQIVALAELLLD
.|..||||||||.|..|||||..|.||.|||||.| |.| .||.| .|||.||...|.|.|.||..|.||...||||.|||||||||||||||||.||||
celeeyypncevvflglanihavrksfnslrallsqspdesnwlsalektkWlqnlsvllkaavkvveavdkegrpvlvhCsdGWdrttqivalakllld

PFYRTIEGFKILIDREWLQFGHRFADRCGHGSDIDE-NERCPVFLQWLDCVHQLQKQFPSSFEFSETYLIKLLHHTYSCLFGTFLGNNEHGRHTDAIKAR
|.|||.||||.|..||||.|||.||||||||...|. ||||||||||||.|||||.|||.||||.|..|.||..|||||||||||.|.|. |.....|.|
pyyrtleGfkvlvereWldfGhkfadrcghgenvddanercPvflqwldavhqlqrqfPtsfefneaflvklvqhtysclfGtflansekereeekvker

TLSVWSYILPRKKDFRNLLYAGG
||||||.. ...|..|||||.  
tlsvWsllrakekeyrnllykek
0040695 (Phosphotyrosine protein) phosphatases II 149-545 7.6e-138 453.2 In-house 8-359 (388) alignment 
Range on Protein: 149-545
Range on HMM: 8-359/388.0
ATPYSFLEEVHRMGFETGvdsPWRISDANSSFEVCRTYPRLHVIPSSISDSDLAKVASFRCSGRFPSIVWRHMTNGAVIARCSQPQVGWLGWRSAEDELL
 . |..|.|. |.|...    .||||. |. .|.|..||.| |.|.||||..|..||.||. ||.| ...|| .||||. |.|||.||.|..|| ||| |
wslydilrelkrlglgld...lwrisivNenyelcpsYPallvVPksisdellkrvarfrskgriPvlsyrhpnngavllRssqplvglllsrsledekl

LQAIGQACTsdrypsvakllngitvnginkkhdmgdvlngpadmsedgpiarNPKQVLIVDARSYTAAYANRGKGGGFEYTEYYPNCEVMFMNLANIHGI
|.|| ....                                           |....||||.|... |.||| .|||.|....|||.|..|.|. ||| .
leailkllp...........................................nlskllivdlrpklnalanralgggvenedaypnaeliflnipnihvv

RRSFHSLRALCSGSYDVPNWWSLIEKTNWLHHISMLIKSAVTIVHAVHTDGRPVVVHCSDGWDRTTQIVALAELLLDPFYRTIEGFKILIDREWLQFGHR
|.|...|. .| .. |. |..||.|...||..|......||.||. .. .. .|.||||||||||.|...||.|||||.|||.||| .|| .|||.|||.
reslqklldaclnvpdslnllslleesgwldliklilelavlivklldlgnssvlvhcsdgwdrtsqlssLaqllldPyYRTleGFqvLiekeWlsfghk

FADRCGHGS-DIDENERCPVFLQWLDCVHQLQKQFPSSFEFSETYLIKLLHHTYSCLFGTFLGNNEHGRHTDAIKARTLSVWSYILPRKKDFRNLLYA
||||.||.  .|| .|..||||..||||.||..|||..|||.|..|. |..|.|||.|||||.|.|. | .  .  ||||.|||.| ||..|.|.|| 
fadRlghleseidskefsPvFllFLdcvwqLlrqfPtaFeFnerlLlfLadhlyscrfgtFlfnsekerlelsvsertlslwsyllsrkseflnplYd
Myotub-related Myotubularin-like phosphatase domain 129-517 6.8e-134 439.1 Pfam-A 5-351 (353) alignment
Myotub-related Myotubularin-like phosphatase domain 129-517 6.8e-134 439.1 In-house 5-351 (353) alignment
subfamily_Dicty-MTMR1-like_pd Subfamily Dicty-MTMR1-like 138-545 1.7e-127 417.9 In-house 5-368 (404) alignment 
Range on Protein: 138-545
Range on HMM: 5-368/404.0
SPNSFTSQDASATPYSFLEEVHRMGFETGVdsPWRISDANSSFEVCRTYPRLHVIPSSISDSDLAKVASFRCSGRFPSIVWRHMTNGAVIARCSQPQVGW
  ....  .   . |.  || .|.|...    .||||..|| .|.| |||.| |.|.||||..| ||||||  ||.| ..|||  ....|.|.|||.|| 
ysekksvledgwliydaeeEykRlgikses..eWriskinsdyelcetYPkllvvPesisDeelkkvasfRskgRiPvlswrhrsknstitRssqplvGl

LGWRSAEDELLLQAIGQACTSDRypsvakllngitvnginkkhdmgdvlngpadmsedgpiarnpkQVLIVDARSYTAAYANRGKGGGFEYTEYYPNCEV
 . || |||.|...| .|.|. .                                           ...|.|||... | ||. || |.| .. | |||.
tksrseedEklinsirkaktqle...........................................tlyildarpkanavansakgagyedisryencei

MFMNLANIHGIRRSFHSLRALCSGSYDV-PNWWSLIEKTNWLHHISMLIKSAVTIVHAVHTDGRPVVVHCSDGWDRTTQIVALAELLLDPFYRTIEGFKI
 |.|..||| .| |...|. ... . .   ||.| .|...|| ||. |.... .||. ..... .|.||||||||||.|...|..|||||.|||||||..
eflnienihelreslkklkkavnsiiekeknwlselessrWldhiklllegskriveliekekssvlvhcsdgwDrtsqlsslsqllldpyyrtiegFiv

LIDREWLQFGHRFADRCGHGSDIDENERCPVFLQWLDCVHQLQKQFPSSFEFSETYLIKLLHHTYSCLFGTFLGNNEHGRHTDAIKARTLSVWSYILPRK
||..|||.||| ||.|.|. .  ...|| |.|||..|||.|| ||||.||||.| .|||.|.. ||| ||||| ..|. |. . ..  | |.|...   |
liekewlsfGhkfaqRigqttekssdersPiflqFidcvyqltkqfptsFeFnekflikildalyscrfgtFLydsekeRqqnnlaketvslWalleank

KDFRNLLYA
... | || 
seylnplyi
subfamily_MTMR1_pd Subfamily MTMR1 301-546 5.6e-101 330.6 In-house 114-360 (389) alignment 
Range on Protein: 301-546
Range on HMM: 114-360/389.0
NPKQVLIVDARSYTAAYANRGKGGGFEYTEYYPNCEVMFMNLANIHGIRRSFHSLRALCSGSYDVPNWWSLIEKTNWLHHISMLIKSAVTIVHAVHTDGR
. ...||.|||| ..| ||. ||.| | .|.| |.|..|....||| .| |.. |..|.  . |  .| | .|.|.||.||......|| ||..|.|   
qsekllildarssvnavankakgkgyeseeaYknaelifldihnihvvReslkklkelvlpnvddkkwlsalestkWlehiklilagavkivekvetekt

PVVVHCSDGWDRTTQIVALAELLLDPFYRTIEGFKILIDREWLQFGHRFADRCGHGS-DIDENERCPVFLQWLDCVHQLQKQFPSSFEFSETYLIKLLHH
 |.||||||||||.|...|| ||||..|||||||..||..|||.|||.|..| |||  .  ..|| |||||..|||.||..|||. ||| |..|| || |
svlvhcsdGWDRtaqltsLamlllDsyyRtieGfevliekeWlsfGHkfkeRlghgdknssdaersPvFlqfiDcvwqltrqfptAFefneefLitlldh

TYSCLFGTFLGNNEHGRHTDAIKARTLSVWSYILPRKKDFRNLLYAG
 ||||||||| |.|. |. . .| .|.|.|||.  .|..|.| ||| 
lysclfGtflfnsekervkekvkektvslwsyvnsskeeftnplyae
subfamily_MTMR6_pd Subfamily MTMR6 301-545 1.2e-89 293.4 In-house 124-368 (397) alignment 
Range on Protein: 301-545
Range on HMM: 124-368/397.0
NPKQVLIVDARSYTAAYANRGKGGGFEYTEYYPNCEVMFMNLANIHGIRRSFHSLRALC-SGSYDVPNWWSLIEKTNWLHHISMLIKSAVTIVHAVHTDG
| . . .||.|    | ||. .| |.| .. | |..  |... ||| .| | . |   .   | .| ...| .|...||.||  ...... | .||...|
nsellyvvdtrpklnalankaagkGyenednysnikfqfvgienihvmreslqkllevvelksksvseflsglessgwlkhikavldasifiakavaeeg

RPVVVHCSDGWDRTTQIVALAELLLDPFYRTIEGFKILIDREWLQFGHRFADRCGHGsDIDENERCPVFLQWLDCVHQLQKQFPSSFEFSETYLIKLLHH
  |.||||||||||.|...||.|||||.||||.||..||..||| |||.| .|||.  | |. |  |.|.|.|.|| ||..||| .|||.|..|..| .|
asvlvhcsdGwdrtaqvcslasllldpyyrtikGflvliekewlsfGhkfsercGll.dedskevsPiftqflecvwqlleqfpkafefnerfllelhdh

TYSCLFGTFLGNNEHGRHTDAIKARTLSVWSYILPRKKDFRNLLYA
 ||| |||||||.|. |.   .| || |.|.|.| ||.|. | || 
vyscqfGtflgncekdrrdlklkertkslwayllerkddylnplyk
subfamily_Ank-MTMR1_pd Subfamily Ank-MTMR1 302-542 2.1e-70 229.5 In-house 129-375 (405) alignment 
Range on Protein: 302-542
Range on HMM: 129-375/405.0
PKQVLIVDARSYTAAYANRGKGGGFEYTEYYPNCEVMFMNLANIHGIRRSFHSLR-ALCSGSYDV-------PNWWSLIEKTNWLHHISMLIKsAVTIVH
 | . ..|||    |.||  .| |||    |||| ..|||. ||| ||.|.  |  |. | . |          .|  ||.| |. ||  ... | |.  
sktlylidarpklnaiantangagfenihnypncklvfmnipnihvirksleklvlamkssardkdhtestdmrfwgyieetgwishiksile.aatfsa

AVHTDGRPVVVHCSDGWDRTTQIVALAELLLDPFYRTIEGFKILIDREWLQFGHRFADRCGHGSDiDENERCPVFLQWLDCVHQLQKQFPSSFEFSETYL
 .   |  ..|||||||||| || .|...||||.|||| ||..||..||| |||.|. | ||    .|.|| |.| |.|||. || .|||  |||. . |
elilkgnsilvhcsdgwdrtpqitsltqilldpyyrtivgfqvliekewlsfghkfslrlghlpg.neeerspifqqfldccfqllsqfpllfeftpsll

IKLLHHTYSCLFGTFLGNNEHGRHTDAIKARTLSVWSYILPRKKDFRNL
. .    .|| .|||| | |. |  | .| .|.|.|| .    . | | 
lfisdnihsckygtflnncekdrvqdqvktktisiwsevnlnvnkflnp
subfamily_MTMR9_pd Subfamily MTMR9 303-545 3.9e-70 228.9 In-house 120-367 (393) alignment 
Range on Protein: 303-545
Range on HMM: 120-367/393.0
KQVLIVDARSYTAAYANRGKGGGFEYTEYYPNCEVMFMNLANIHGIRRSFHSLRALCSG-SYDVPNWWSLIEKTNWLHHISMLIKSAVTIVHAVHTDGRP
|. |||| || .|| ..| ||||.| .. |.. .    .|.... |  |.  |   ||  . .  ...| .||..||...  |.. |..........| |
kkGlivdtrsksaaenarskgggietevkysqwkkasrslesvasiqdslaklleacsdaglstdkflsrleksgwlsqvadlleaalvvaqcldeegap

VVVHCSDGWDRTTQIVALAELLLDPFYRTIEGFKILIDREWLQFGHRFADRCGHGSDID--ENERCPVFLQWLDCVHQLQKQFPSSFEFSETYLIKLLHH
|||| ..| | | |...|| |.||| .||..||. ||.|||.| || || |. . .  .  .... |||| .||||.|. .||| ||||.|..|| | .|
vvvhgeeGlDatlqvtsLaqlildpdaRtvrgfealiereWiqaGHPFasRaskvaaketkkklsgpvfllFLDcvyqilsqfpasFEFneelLillfeh

TYSCLFGTFLGNNEHGRHTDAIKARTLSVWSYILPR--KKDFRNLLYA
.||. |||||..||. |..  .| .| |.|||.      |.| |.|| 
syssqfgtflcdneaerkelklkkktvslwsyvnrpeklkqflnplye
subfamily_MTMR5_pd Subfamily MTMR5 329-533 2.1e-60 196.9 In-house 222-441 (483) alignment 
Range on Protein: 329-533
Range on HMM: 222-441/483.0
TEYYPNCEVMFMNLANIHGIRRSFHSLRALCSGSYDVPN-----WWSLIEKTNWLHHISMLIKSAVTIVHAVHTDGRPVVVHCSDGWDRTTQIVALAELL
.| . ..|.. ..| .|  ...||. |.  |. | .| .     . ...|. .||. || |.. ....|  .  .|  |.|   |||| |.|...||.||
sevdskaefipvelveirqvkasfkkllraClpstaveeaesqsFlksvedseWlqqissllqlsgavvdlldlqgssvlvslEdGwdvtaqvsslaqll

LDPFYRTIEGFKILIDREWLQFGHRFADRCGHGSDIDENERCPVFLQWLDCVHQLQKQFPSSFEFSETYLIKLLHHTYSCLFGTFLGNNEHGRHTDAI--
|||.|||.||||.|...||| |||||..|. .     .    |||||.||||||...||| .|||.. ||  | .|  |. | ||| . |. |   ..  
ldpyYRtleGFkvLveKEWLafGHrFtkrsnqtlsaqssgfaPvFlqFLDcvhqvsrqfPlafefndfylkflayhsvsnrfrtfllDseyerlesglly

--------KARTLSVWSYIL
        |  . ||| || 
eekaekrakkagksvwdyid
subfamily_MTMR10_pd Subfamily MTMR10 341-524 1.3e-54 177.4 In-house 122-310 (380) alignment 
Range on Protein: 341-524
Range on HMM: 122-310/380.0
NLANIHGIRRSFHSLRALCSGSYDV------PNWWSLIEKTNWLHHISMLIKSAVTIVHAVHTDGRPVVVHCSDGWDRTTQIVALAELLLDPFYRTIEGF
.|..|. . .... ||.||  .         ..| |..|||.||. ...... |. .|..|....|.|..  |.| |    .  || |.|||.||||.||
elpsiqdvqkaylklreLcvidtseefvtlddkwlssLektrWLayvrlclstasdavktvvekkrsvilqesegrDlscvvaSLaqlmldphyrtisGf

KILIDREWLQFGHRFADRCGHGSDIDENERcPVFLQWLDCVHQLQKQFPSSFEFSETYLIKLLHHTYSCLFGTFLGNNEHGRHTDAIKAR
. ||..||   || | ||.||. . ...|  ||||  ||||.|| .||||.|||.||.||.|. ...|..|.||| |.|. | .   .  
qsliqkewvaaghpfldrlghikpsekses.pvfllFldcvdqlleqfpseFeFtetfLialwdsshsgifltflfnseeqrlkavvsss
subfamily_MTMR1_pd Subfamily MTMR1 152-256 1.1e-27 89.4 In-house 10-112 (389) alignment 
Range on Protein: 152-256
Range on HMM: 10-112/389.0
YSFLEEVHRMGFETGVdsPWRISDANSSFEVCRTYPRLHVIPSSISDSDLAKVASFRCSGRFPSIVWRHMTNGAVIARCSQPQVGWLGWRSAEDELLLQA
|.. .|..|.|  .     |||.. |...|.| |||.. |.|...||.|| |||.||  ||.|...| . .|.|||.|.||| ||  | ||.||| .|||
ydpeaelerlgllnek..lWritklnkkyelcdtYpavlvvpkvvsdedlkkvaafrskgRlPvlswlnkenqavilrasqplvGlsgkrskedekylqa

IGQAC
| .| 
ilean
subfamily_MTMR9_pd Subfamily MTMR9 152-251 2.1e-24 78.3 In-house 15-114 (393) alignment 
Range on Protein: 152-251
Range on HMM: 15-114/393.0
YSFLEEVHRMGFETGVDSPWRISDANSSFEVCRTYPRLHVIPSSISDSDLAKVASFRCSGRFPSIVWRHMTNGAVIARCSQPQVGWLGWRSAEDELLLQA
||  .. . ..  . . . ||||. |  |.|| .||   ..| .|.| .| ..|.||  |||| . ..| ...||. |.||| .|  | |  ||| ||..
ysafdrenefaklisasdewRissvNknfkvcasypesvivPkaiddeelkasaafreggrfPvLsylhketkavllrssqplcgssgkrckedekllnl
subfamily_pats1_pd Subfamily pats1 334-460 6.4e-24 76.3 In-house 335-464 (691) alignment 
Range on Protein: 334-460
Range on HMM: 335-464/691.0
NCEVMFMNLANIHGIRRSFHSLRALCSGSYDVPNWWSLIEKTNWLHHISMLIKSAVTIVHAVHtDGRPVVVH-CSDGWDRTTQI---VALAELLLDPFYR
 ....|..|   . ..  |. |        .  . |. ||.  |.  . .|...|| .   .  .|. |...  .|. . . ..    .|| .|.|||||
ssniiflslPtrekveerffdllqsilsldgsddewkeieeskwvdsvkllleaavkvsnlld.eGssvllknsidsPlieldlasisslaqvlsdPfyr

TIEGFKILIDREWLQFGHRFADRCGHGSDID
|..|||.||..|||..|. |.... |  . |
tldGfkvliekewlsyGfPfskinyhkesdd
subfamily_pats1_pd Subfamily pats1 465-545 1.1e-21 69.0 In-house 553-633 (691) alignment 
Range on Protein: 465-545
Range on HMM: 553-633/691.0
CPVFLQWLDCVHQLQKQFPSSFEFSETYLIKLLHHTYSCLFGTFLGNNEHGRHTDAIKARTLSVWSYILPRKKDFRNLLYA
 |.|.|.|| | ||||.||  ||| | .|. |.....|  ||.|| ..   .    .  |. |.||.|   |  | |||| 
sPifvqfldlvwqlqkefPfhfefneslllllvkesfssrfGnflyseakrdserkvlkrsksiwsfinqnksrfinllyk
subfamily_MTMR5_pd Subfamily MTMR5 155-233 5.6e-21 66.9 In-house 11-93 (483) alignment 
Range on Protein: 155-233
Range on HMM: 11-93/483.0
LEEVHRMGFETG----VDSPWRISDANSSFEVCRTYPRLHVIPSSISDSDLAKVASFRCSGRFPSIVWRHMTNGAVIARCSQP
. . .|.|...        ..||| .|....|||.|| | |.||..||. .|.||     .|.| ..|||  |.|.. | ...
vqdykRlGlgalngaskrgkfrisevNkkytvcrsYPalivvPsevsddsiarvakcfrqnRlPvvtWrhernkalLiRsggf
subfamily_MTMR6_pd Subfamily MTMR6 132-261 9.9e-21 66.4 In-house 2-127 (397) alignment 
Range on Protein: 132-261
Range on HMM: 2-127/397.0
YAWSMASPNSFTSQDASATPYSFLEEVHRMGFEtgvDSPWRISDANSSFEVCRTYPRLHVIPSSISDSDLAKVASFRCSGRFPSIVWRHMTNGAVIARCS
||.|. . .. ... .  . ..  .|..|||     .. | ..|.| ..|.| ||||  ..|.|.. . |   . ||  ||.| . . | .| | | |||
yafsykpkkdkeekvsGwklldlkaeytrmgvp...nekwtltdlnkdyelcdtyprelyvPksatkevlvgsskfrskgrlPvlsylhkeneaaicrcs

QPQVGWLGwRSAEDELLLQAIGQACTSDRY
||  |    |. ||| ||.|| .| .. ..
qplsgfsa.rcledeklleairkanpnsel
subfamily_Ank-MTMR1_pd Subfamily Ank-MTMR1 168-256 1.2e-17 55.8 In-house 39-127 (405) alignment 
Range on Protein: 168-256
Range on HMM: 39-127/405.0
DSPWRISDANSSFEVCRTYPRLHVIPSSISDSDLAKVASFRCSGRFPSIVWRHMTNGAVIARCSQPQVGWLGWRSAEDELLLQAIGQAC
.. |.... |  ...| .|.   |. |   | || |. |||  || ||. |.  .  | |.||||| ||    |  ||||   ..  ..
ncywkvtsinkeykmcssyssslvvlskaldkdlekifsfrskgripslswkdpssnasisrcsqplvgierarcpedelycsslalsa
PTPc_DSPc_SM00012 385-496 5.5e-13 44.4 In-house 19-100 (105) alignment 
Range on Protein: 385-496
Range on HMM: 19-100/105.0
IKSAVTIVHAVHTDG------RPVVVHCSDGWDRTTQIVALAELLLDPFYRTiegfkilidrewlqfghrfadrcghgsdidenercpVFLQWLDCVHQL
 .| .....||..         |||||||.|..|| ..|||. || .  ..|                                     .......|..|
sdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleket....................................kevdifqivkel

QKQFPSSFEFSETYLIKL
 || |..... | ||. .
rkqRpgmvqteeqylfly
0051429 (Phosphotyrosine protein) phosphatases II 331-487 2.8e-10 35.8 In-house 66-209 (272) alignment 
Range on Protein: 331-487
Range on HMM: 66-209/272.0
YYPNCEVMFMNLANIHGIRRSFHS------------------LRALCSGSYDVPNWWSLIEKTNWLHHISML--IKSAVTIVHAvhtdGRPVVVHCSDGW
| |......... . .  . ...                   |..    |.. . .. ..  |.|. |      ..... ....    |.||.|||| |.
ywpgirylhlpilddsaptilygalrvtllseellldyilrellltlllsagearevmhlhytdwpdhgvpqeallellellld....ggpvlvHCsaGk

DRTTQIVALAELLLDpfyrtiegfkilidrewlqfghrfadrcghgsdidenercpvfLQ--------------WLDCVHQLQKQFPSSFE
|||  .|||  |||.                                           .               ....|..|..|.| ...
dRTGtvvallllllg...........................................vsletivddYlltnlyleeaveelraqrpgavq
subfamily_MTMR10_pd Subfamily MTMR10 166-234 3.5e-10 31.2 In-house 21-88 (380) alignment 
Range on Protein: 166-234
Range on HMM: 21-88/380.0
GVDSPWRISDANSSFEVCRTYPRLHVIPSSISDSDLAKVASFRCSGRFPSIVWRHmTNGAVIARCSQPQ
 |.  .. .  |  |... |.|.  |.| |.||||. ..    . .|||  || | ..||.  |.|. |
tvsdaivvllknelfaaaqtlPqyfvvpnslsdsdverlsrhykesRfplwvwsh.akgaallrlsalq
0049772 (Phosphotyrosine protein) phosphatases II 302-424 1.1e-09 34.0 In-house 92-237 (314) alignment 
Range on Protein: 302-424
Range on HMM: 92-237/314.0
PKQVLIVDARSYTAAYAN---------------------------------------------RgkgggfeyteyypnCEVMFMNLANIHgirrsfhslr
|... .|| |.    | |                                                            .|  ...|....          
pleitvvdfreepvlyyngwrmvlrgdlnvrdivmsrdevladelsrLdaAlgKtpllildgng..............neptaadlellk..........

alcS---GSYDVPNWWSLIEKTNWLHHISMLIKSAVTIVHAVHT--DGRPVVVHCSDGWDRTTQIVALAELLL
   .      .....      ...  .   |..    .......  .|.||.|||..|..||.  |..| |..
...eelydpelferlgikylripvpDgsaplledfdeflefieeadkggpvlvHCkaGkgRtgtfvvaaylmk
0045098 (Phosphotyrosine protein) phosphatases II 341-423 4.3e-09 31.6 In-house 140-230 (278) alignment 
Range on Protein: 341-423
Range on HMM: 140-230/278.0
NLAN-----IHGIRRSFHSLRALCSGSYDVPNWW---SLIEKTNWLHHISMLIKSAVTIVHAVHTDGRPVVVHCSDGWDRTTQIVALAELL
.. |      ..  | .. |  |.   ..||.     |..| ......   |. | ... . .. .| ||.|||| |..||  .||.  .|
lvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsggpvlVHCsaGvgRtGtlvaaylml
subfamily_pats1_pd Subfamily pats1 152-229 1.2e-08 25.8 In-house 9-82 (691) alignment 
Range on Protein: 152-229
Range on HMM: 9-82/691.0
YSFLEEVHRMGFEtgVDSPWRISDANSSfEVCRTYPRLHVIPSSISDSDLAKVASfRCSGRFPSIVWRHMTNGAVIAR
|| | | .|.. .  .|  ||. .  |. ...  ||.  ..| ..||  |   .  . | ..| . | . .| ... |
yslliegqrlkld..ldkdwrvveflsr.dlseiyPkrilvPklvsdellvsyvr.krsskiPvlswsnqnnksslfr
0039614 (Phosphotyrosine protein) phosphatases II 347-421 2.3e-08 29.3 In-house 165-244 (297) alignment 
Range on Protein: 347-421
Range on HMM: 165-244/297.0
GirRSFHSLRALCSGSYDVPNWWSLIEKTNWLHHISM-LIKSAVTIVHAVHT------DGRPVVVHCSDGWDRTTQIVALAE
   ..   .| |.   .. .  .  .  |.| .|    ....   ....|..      .|.||.||||.| .||  ..|.  
h..ldgytvrtlevtnngesrtvthfqytgwpdhgvppslellleflelvrealaelpkggpvlVHCsaGvgRtGtfiaayl
0046846 (Phosphotyrosine protein) phosphatases II 362-424 4.6e-08 28.5 In-house 62-134 (176) alignment 
Range on Protein: 362-424
Range on HMM: 62-134/176.0
SYDVPNWWSLIEKTNWLHHIS----------MLIKSAVTIVHAVHTDGRPVVVHCSDGWDRTTQIVALAELLL
....||.|...|| .. ..             |. ... ... . ..|.||.|||| |  ||  .||.  | |
rlkcpnywpeleklgiqylhlpwpDhgvpdlelllellefirealkeggpvlVHCsaGigRtgtlvaayllel
0044763 (Phosphotyrosine protein) phosphatases II 381-419 5.2e-08 28.2 In-house 91-130 (178) alignment 
Range on Protein: 381-419
Range on HMM: 91-130/178.0
ISMLIKSAVTIVHAVH-TDGRPVVVHCSDGWDRTTQIVAL
..  .  .| ...... ..|.||.|||| |..|.. .||.
llehflefvefieealdekggpvlVHCsaGvgRsgtlvaa
0048179 (Phosphotyrosine protein) phosphatases II 381-420 8.4e-08 27.6 In-house 65-104 (144) alignment 
Range on Protein: 381-420
Range on HMM: 65-104/144.0
ISMLIKSAVTIVHAVHTDGRPVVVHCSDGWDRTTQIVALA
.. |. ... ...... .|.||.|||| | .||. .||. 
llellleflefieealeeggpvlVHCsaGvgRtgtlvaay
0043336 (Phosphotyrosine protein) phosphatases II 363-422 9.2e-08 27.4 In-house 169-233 (278) alignment 
Range on Protein: 363-422
Range on HMM: 169-233/278.0
YDVPNWWSLIEKTNWLHH-----ISMLIKSAVTIVHAVHTDGRPVVVHCSDGWDRTTQIVALAEL
.. . .   .  ..| .|     .|.|..   .. .|..... ||.||||.| .||  ..||  |
dgesrtvthyhylgwpdhgvpeslsllldflkavrealedsngpvlVHCsaGvgRTGtfialyll
0048076 (Phosphotyrosine protein) phosphatases II 381-420 9.9e-08 27.3 In-house 63-102 (145) alignment 
Range on Protein: 381-420
Range on HMM: 63-102/145.0
ISMLIKSAVTIVHAVHTDGRPVVVHCSDGWDRTTQIVALA
.. |. ... ...... .|.||.|||| | .||. .||. 
llellleflefieealkeggpvlVHCsaGvgRtgtlvaay
0041856 (Phosphotyrosine protein) phosphatases II 372-420 1e-07 27.2 In-house 82-130 (182) alignment 
Range on Protein: 372-420
Range on HMM: 82-130/182.0
IEKTNWLHHISMLIKSAVTIVHAVHTDGRPVVVHCSDGWDRTTQIVALA
. ...|  |    . ... ....|. .|.||.|||| | .||  .||. 
ylylpwpDhgvpdldelldfieevleeggpvlVHCsaGvgRtgtlvaay
0051082 (Phosphotyrosine protein) phosphatases II 376-423 1.2e-07 27.0 In-house 68-116 (151) alignment 
Range on Protein: 376-423
Range on HMM: 68-116/151.0
NWLHHISMLIKSAVTIVHAVHTD-GRPVVVHCSDGWDRTTQIVALAELL
.. . ......... .....  . . ||.|||| |..||  .|||  .|
wpdpglplsfdavleflellldkkngpvlvHCsaGkgRTGtlvalylml
0045450 (Phosphotyrosine protein) phosphatases II 378-420 1.2e-07 27.3 In-house 207-255 (307) alignment 
Range on Protein: 378-420
Range on HMM: 207-255/307.0
LHHISMLIKSAVTIVHAVHT------DGRPVVVHCSDGWDRTTQIVALA
 |...  ..... ....|..      .| ||.||||.| .||  ..|. 
dhgvppsfeelldfieevrkaleelpkggpvlVHCsaGvgRtGtfiaay
subfamily_MTMR14_pd Subfamily MTMR14 391-460 1.2e-07 22.9 In-house 259-335 (357) alignment 
Range on Protein: 391-460
Range on HMM: 259-335/357.0
IVHAVHTDG-RPVVVHCSDGWDRTTQIVALAELLL--D-PFYRTIEGFKI---LIDREWLQFGHRFADRCGHGSDID
... |. |.   ..|||  |||||   |.|  | |  |   .....  ..    .  .|. |||...||  .| .| 
llkyvkededsGllvhcisGWdrtPlfvsllrlslWadglihqslsaaellyltvaydWflfghqlpdrlkkgeeil
0040439 (Phosphotyrosine protein) phosphatases II 378-421 1.3e-07 26.9 In-house 152-201 (249) alignment 
Range on Protein: 378-421
Range on HMM: 152-201/249.0
LHHISMLIKSAVTIVHAVHT------DGRPVVVHCSDGWDRTTQIVALAE
 |...  ..... ...||..      .| ||.||||.| .||  ..|.  
dhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaayl
0036282 (Phosphotyrosine protein) phosphatases II 373-425 1.5e-07 26.8 In-house 66-130 (174) alignment 
Range on Protein: 373-425
Range on HMM: 66-130/174.0
EKTNWLHH-----------ISMlIKSAVTIVHAVHTD--GRPVVVHCSDGWDRTTQIVALAELLLD
|.... ..           .|. . ..| .|. .. .  |.||.|||| | .||  .||.  .|  
erlgiqylylpwpDhgvpdlsi.llefvkfveealsedpggpvlVHCsaGvgRtGtlvaaylmlrg
0043147 (Phosphotyrosine protein) phosphatases II 380-420 1.6e-07 26.7 In-house 76-121 (172) alignment 
Range on Protein: 380-420
Range on HMM: 76-121/172.0
H---ISMLIKSAVTIVHA--VHTDGRPVVVHCSDGWDRTTQIVALA
|   .. |. ... ...   .  .| ||.|||| |..||  .||. 
hgvpllellleflefidellalspggpvlVHCsaGvgRtgtlvaay
0042113 (Phosphotyrosine protein) phosphatases II 374-421 4.3e-07 25.1 In-house 145-198 (245) alignment 
Range on Protein: 374-421
Range on HMM: 145-198/245.0
KTNWLHHISML-IKSAVTIVHAVHT-----DGRPVVVHCSDGWDRTTQIVALAE
 ..| .|     ... . ....|..     .. ||.||||.| .||  ..|.  
ylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaayl
0037934 (Phosphotyrosine protein) phosphatases II 376-422 4.3e-07 25.2 In-house 142-201 (243) alignment 
Range on Protein: 376-422
Range on HMM: 142-201/243.0
NWLH--------HISMLIKSAVTIVHA-----VHTDGRPVVVHCSDGWDRTTQIVALAEL
.| .        ..  ... . .....     .  .|.||.|||| | .||  ..|.  .
pwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRtGtliaaylm
0049260 (Phosphotyrosine protein) phosphatases II 380-421 6.2e-07 24.7 In-house 69-111 (152) alignment 
Range on Protein: 380-421
Range on HMM: 69-111/152.0
HISMLIKSAVTIVHA-VHTDGRPVVVHCSDGWDRTTQIVALAE
 .|.|.. .. ...   . .| ||.|||| | .||  .||.  
dlsqlllflllfieklaldkggpvlVHCsaGvgRtgtlvaayl
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 375-421 8.4e-07 23.3 In-house 184-231 (307) alignment 
Range on Protein: 375-421
Range on HMM: 184-231/307.0
TNWLHHI-SMLIKSAVTIVHAVHTDGRPVVVHCSDGWDRTTQIVALAE
.||  .    .  .|. ...||. |  ||||||| |  |.  |||.. 
enwpdrgvpqinltainlleavrydtnpvvvhcsaGvGrsGtivaisl
0040438 (Phosphotyrosine protein) phosphatases II 379-421 1.5e-06 23.2 In-house 185-231 (317) alignment 
Range on Protein: 379-421
Range on HMM: 185-231/317.0
HHISMLIKSAVTIVHAVHTD----GRPVVVHCSDGWDRTTQIVALAE
|..   ... . ...||..     | ||.||||.| .||  ..|.  
hgvppspdllldfleavrealedpggpvlVHCsaGvgRtGtfiaayl
0047943 (Phosphotyrosine protein) phosphatases II 374-422 1.6e-06 23.3 In-house 173-228 (273) alignment 
Range on Protein: 374-422
Range on HMM: 173-228/273.0
KTNWLHHISM-LIKSAVTIVHAVHT------DGRPVVVHCSDGWDRTTQIVALAEL
 |.|  |     ..| ......|..      .. |||||||.|  ||  ..||  |
ytgwpdhgvppslesllefielvrkalealpsngpvvVHCsaGvgRtgtfialdll
0036941 (Phosphotyrosine protein) phosphatases II 378-421 1.7e-06 23.0 In-house 180-229 (297) alignment 
Range on Protein: 378-421
Range on HMM: 180-229/297.0
LHHISMLIKSAVTIVHAVHT------DGRPVVVHCSDGWDRTTQIVALAE
 |..   ..| . ....|..      .| ||.||||.|  |.  ..|.  
dhgvpespaslldfielvrkvlkllpsggpvlVHCsaGvgRsgtfiaadl
DSPc_SM00195 374-492 1.8e-06 22.8 In-house 165-251 (263) alignment 
Range on Protein: 374-492
Range on HMM: 165-251/263.0
KTNWLHHiSM--LIKSAVTIVHAVHTDGR----PVVVHCSDGWDRTTQIVALaELLLDPFYRTIEgfkilidrewlqfghrfadrcghgsdidenercpv
 .|| .| ..    || . ...||... .    |.|||||.| .||  .|.. ...|. . .. .                                   
yknWpdh.gvpdstksvlellravkkskstssgpivVhCsaGvgRtgtfvti.diilskleeekk...................................

fLQWLDCVHQLQKQFPSSFEFSETY
 ..  ..| .| || |.... .| |
.vdifeivkelRkqRpgmvqtleqY
PTPc_SM00194 374-492 1.8e-06 22.8 In-house 165-251 (263) alignment 
Range on Protein: 374-492
Range on HMM: 165-251/263.0
KTNWLHHiSM--LIKSAVTIVHAVHTDGR----PVVVHCSDGWDRTTQIVALaELLLDPFYRTIEgfkilidrewlqfghrfadrcghgsdidenercpv
 .|| .| ..    || . ...||... .    |.|||||.| .||  .|.. ...|. . .. .                                   
yknWpdh.gvpdstksvlellravkkskstssgpivVhCsaGvgRtgtfvti.diilskleeekk...................................

fLQWLDCVHQLQKQFPSSFEFSETY
 ..  ..| .| || |.... .| |
.vdifeivkelRkqRpgmvqtleqY
0051299 (Phosphotyrosine protein) phosphatases II 375-422 1.8e-06 23.1 In-house 190-242 (288) alignment 
Range on Protein: 375-422
Range on HMM: 190-242/288.0
TNWLHHISML-IKSAVTIVHAVH----TDGRPVVVHCSDGWDRTTQIVALAEL
||| .|     ... ......|.     .| |||||||.| .||  ..||  |
tnwpdhgvpdspellldflrlvrkalasgggpvvVHCsaGvgRtgtfialdll
0050432 (Phosphotyrosine protein) phosphatases II 385-422 3.5e-06 22.0 In-house 219-255 (308) alignment 
Range on Protein: 385-422
Range on HMM: 219-255/308.0
IKSAVTIVHAVHtDGRPVVVHCSDGWDRTTQIVALAEL
. . . .|. .. .| |.|||||.|  ||  ..||  |
lldflelvrksl.pggpivVHCsaGvGRtGtfialdll
0046845 (Phosphotyrosine protein) phosphatases II 373-423 4.7e-06 21.7 In-house 171-228 (284) alignment 
Range on Protein: 373-423
Range on HMM: 171-228/284.0
EKTNWLHHISM----LIKSAVTIVHAVHTD---GRPVVVHCSDGWDRTTQIVALAELL
  |.| .|        . . . .|. ....   | |.|||||.|  ||  ..||  ||
hytswpdhgvppspedlleflrlvrellenlpgggpivVHCsaGvgRtGtfialdlll