Gene MTMR5 in Nematostella vectensis

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family Myotubularin
Subfamily MTMR5
Protein sequence
ID Type Fasta BLAST phosphatome Note
NvecP030_AA protein Get Run
NvecP030_AA_1122-1599 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_MTMR5_pd Subfamily MTMR5 1126-1595 1.5e-212 698.7 In-house 4-483 (483) alignment 
Range on Protein: 1126-1595
Range on HMM: 4-483/483.0
SM---PCCQDYSRLGFGNILRASAGGPWRISMVNYTYTVCRSYPAVVVVPQSISDDTVLRVAKNHRQNRFPVAIWKHPKNKATLVRAGGIERSSVASMIR
..    ..|||.|||.|.. .||. |..|||.||..|||||||||..|||...|||.. ||||..||||.||..|.|..|||.|.|.||.|...|.....
klaerayvqdykRlGlgalngaskrgkfrisevNkkytvcrsYPalivvPsevsddsiarvakcfrqnRlPvvtWrhernkalLiRsggfeskgvvgllk

SGMGVGGSMSGNSIPSSSVEQEKLFAAVAKAITIYWVFCIRSQSCCFPAVSATPLSKNKSVARQNSlhhgviLNTEGYFNQDKRDETDRGQLVE----AT
| ...| |.| .|  |.|.||||...||.............|.......|.|.. |..|..|....       |.  . ..||......|. ..    ..
santqgsstsessessksleqekylkavvnevsklsalalnsslevslsvlasssssdkraalste......knaldisksdkasqggkgatlkennake

LKKKGWEPAALYVLGDKAHLRNVKQEAYPKCEFVPVELPDVRAVRACFKKFLRACCPATD----SPISFVQQVNESEWLHQLSAVMNVSNVLVDLIDIQG
 ||. .. |||||||.|..|.|||.|.. |.||.||||...|.|.|.|||.||||.|.|.    .. ||...|..||||.|.|.....|...|||.|.||
skklrarkaaLYvlgeksqlknvksevdskaefipvelveirqvkasfkkllraClpstaveeaesqsFlksvedseWlqqissllqlsgavvdlldlqg

SSVMVCFEDGWDVTAQVVCLAEICLDSHYRSIEGFKTLIEKEWLGFGHRFTQRCNQVESAQS-GFTPVFLQFLDAVHQIMRQYPLSFEFNDHFLCTLAYH
|||.|..||||||||||..||...||..||..||||.|.|||||.||||||.|.||..|||| ||.||||||||.|||..||.||.|||||..|..||||
ssvlvslEdGwdvtaqvsslaqllldpyYRtleGFkvLveKEWLafGHrFtkrsnqtlsaqssgfaPvFlqFLDcvhqvsrqfPlafefndfylkflayh

HVSMRFRTFLMDSEHERYQAGWMIEEEGKRRGK----SLWDYIDAQNQRSPAFYNFMYSPDNQKVLRPFCRISNLVVWKYYLTENL
.||.||||||.|||.||...|...||....| |    |.|||||.|..|||.||||.||||...||||....|.| ||.|||.|.|
svsnrfrtfllDseyerlesgllyeekaekrakkagksvwdyidrqhkrspifynflyspdesevlrPssnvsslkvWdyyleeel
0040695 (Phosphotyrosine protein) phosphatases II 1125-1594 8.6e-110 360.9 In-house 9-385 (388) alignment 
Range on Protein: 1125-1594
Range on HMM: 9-385/388.0
SSMPCCQDYSRLGFGNilrasagGPWRISMVNYTYTVCRSYPAVVVVPQSISDDTVLRVAKNHRQNRFPVAIWKHPKNKATLVRAGGIERssvasmirsg
|   ......|||.|.        .|||| ||  |..|.||||..|||.||||... |||.  ...|.|| ...||.|.|.|.| . .            
slydilrelkrlglgl.......dlwrisivNenyelcpsYPallvVPksisdellkrvarfrskgriPvlsyrhpnngavllRssqplv..........

mgvggsmsgNSIPSSSVEQEKLFAAVAKAITiywvfcirsqsccfpavsatplsknksvarqnslhhgvilntegyfnqdkrdetdrgqlveatlkkkgw
         . . |.|.|.|||. |. |...                                                                     
.........glllsrsledeklleailkllp.....................................................................

epaalyvlgD--------KAHLRN-----------VKQEAYPKCEFVPVELPDVRAVRACFKKFLRACcPATDSPISFVQQVNESEWLHQLSAVMNVSNV
         .             |            ...|||..|......|... ||....|.|.||   ...  ..   ..||.||.... ..... .
.........nlskllivdlrpklnalanralgggvenedaypnaeliflnipnihvvreslqklldac.lnvpdslnllslleesgwldliklilelavl

LVDLIDIQGSSVMVCFEDGWDVTAQVVCLAEICLDSHYRSIEGFKTLIEKEWLGFGHRFTQRCNQVES--AQSGFTPVFLQFLDAVHQIMRQYPLSFEFN
.|.|.| ..|||.|. .|||| |.|...||...||..||..||| .||||||| |||.| .|....||   ...|.||||.|||.|.|..||.|..||||
ivklldlgnssvlvhcsdgwdrtsqlssLaqllldPyYRTleGFqvLiekeWlsfghkfadRlghleseidskefsPvFllFLdcvwqLlrqfPtaFeFn

DHFLCTLAYHHVSMRFRTFLMDSEHERYQAGWmieeegKRRGKSLWDYIDAQNQRspaFYNFMYSPDNQKVLRPFCRISNLVVWKYYLTEN
...| .||.|..| ||.|||..||.||.....       .|. |||.|.  ....   |.|..|.|.   ||.|......|..| .|  ..
erlLlfLadhlyscrfgtFlfnsekerlelsv......sertlslwsyllsrkse...flnplYdpsslevllpslsvldlllWleyylrw
Myotub-related Myotubularin-like phosphatase domain 1122-1532 4.8e-102 334.3 Pfam-A 19-352 (353) alignment
Myotub-related Myotubularin-like phosphatase domain 1122-1532 4.8e-102 334.3 In-house 19-352 (353) alignment
SBF2 Myotubularin protein 522-755 1e-85 275.9 Pfam-A 16-225 (225) alignment 
Range on Protein: 522-755
Range on HMM: 16-225/225.0
QHYMAGRKLEVLKDCVSYIFDNKISEARKALPSVLRSLKSKGAQLALCHELSLRAKQNRSVLEHDQFDLVVRLMNNALQEDASMDNTAVAAALLPLTSTF
..    |.||||..|.||||||||.||.| || |||.|||| | ||||.||.....|||.||.|.||||||||||.|||.|...|. .||||||||.|.|
tvensarrlEvlrnCisyiFdnkileakKslpAvlralkskaaRlalceelekhvqqnravLdhqqFDlvvrlmNkaLqddsakdeygvaaallplssaf

CRKLATGCMQFAYTCVQDHPIWEKQQFWEEAFYTDVQTQIKQLYIVeeapravaedtlekpdrssrssltPSAKHRSFTGKENMLSKESRDSSDSETYFQ
||||..| .|||||||||||.|. |||||..||..||..||.||                           ...... . .|. |||... |.   .  |
cRKLsegvsqfaYtcvqdHpvWknqqFWeatfyqevqkaikelyle........................kkseskkkkktesslskkeeksaleiaadq

IKKWATMKQEERDNLISSEESIVYSQAIHYANRM
..||.|...|.. .|...||| |||||||.|||.
lrkwptlskekqkelvkkeestvysqaihfanrl
subfamily_MTMR1_pd Subfamily MTMR1 1342-1591 2.1e-70 230.0 In-house 141-383 (389) alignment 
Range on Protein: 1342-1591
Range on HMM: 141-383/389.0
KQEAYPKCEFVPVELPDVRAVRACFKKFLRACCPATDSpISFVQQVNESEWLHQLSAVMNVSNVLVDLIDIQGSSVMVCFEDGWDVTAQVVCLAEICLDS
..||| ..|.. ........||. .||.  .. | .|.  ..........||........ .  .|. .... .||.|...|||| |||.. || . |||
seeaYknaelifldihnihvvReslkklkelvlpnvdd.kkwlsalestkWlehiklilagavkivekvetektsvlvhcsdGWDRtaqltsLamlllDs

HYRSIEGFKTLIEKEWLGFGHRFTQRCNQV--ESAQSGFTPVFLQFLDAVHQIMRQYPLSFEFNDHFLCTLAYHHVSMRFRTFLMDSEHERYQAgwmiee
.||.||||..||||||| |||.|..|  .   .|...  .||||||.|.|.|..||.|  ||||..|| ||. |  | .| |||..||.|| ..      
yyRtieGfevliekeWlsfGHkfkeRlghgdknssdaersPvFlqfiDcvwqltrqfptAFefneefLitlldhlysclfGtflfnsekervke......

EGKRRGKSLWDYIDAQNQRspaFYNFMYSPD-NQKVLRPFCRISNLVVWKYYL
. |..  ||| |.......   | | .|... ..||| | . ...| .|| | 
kvkektvslwsyvnsskee...ftnplyaeelekkvlypkaslrrlelWkeyy
subfamily_MTMR3_pd Subfamily MTMR3 1343-1588 6.1e-68 222.6 In-house 199-436 (442) alignment 
Range on Protein: 1343-1588
Range on HMM: 199-436/442.0
QEAYPKCEFVPVELPDVRAVRACFKKfLRACCPATDSPISFVQQVNESEWLHQLSAVMNVSNVLVDLIDIQGSSVMVCFEDGWDVTAQVVCLAEICLDSH
.| ||.|| | ..|... |||  |.. ||| .  .  .. .. .... .||..|| ... .  .|. .| .| .|.|   |||| |.|.|.||...|| .
eeyypncevvflglanihavrksfns.lrallsqspdesnwlsalektkWlqnlsvllkaavkvveavdkegrpvlvhCsdGWdrttqivalakllldpy

YRSIEGFKTLIEKEWLGFGHRFTQRCNQVES--AQSGFTPVFLQFLDAVHQIMRQYPLSFEFNDHFLCTLAYHHVSMRFRTFLMDSEHERYQagwmieEE
||..|||| |.|.||| |||.|. || . |    .   .|||||.||||||. ||.| |||||. ||  |. |  |  | |||..||.|| .      |.
yrtleGfkvlvereWldfGhkfadrcghgenvddanercPvflqwldavhqlqrqfPtsfefneaflvklvqhtysclfGtflansekeree......ek

GKRRGKSLWDYIDAQNQrspAFYNFMYSPDNQKVLRPFCRISNLVVWK
 |.|  |.|... |...   .. |..|......|| | ... .| .|.
vkertlsvWsllrakek...eyrnllykekteavllpavsvrelklws
subfamily_MTMR6_pd Subfamily MTMR6 1342-1588 4.3e-61 199.3 In-house 151-389 (397) alignment 
Range on Protein: 1342-1588
Range on HMM: 151-389/397.0
KQEAYPKCEFVPVELPDVRAVRACFKKFLRACCPATDSPISFVQQVNESEWLHQLSAVMNVSNVLVDLIDIQGSSVMVCFEDGWDVTAQVVCLAEICLDS
... |  ..|  |.. ..  .|.  .|.| ..   . |  .|.. ...|.||. . ||...| ..   .  .| ||.|   |||| ||||..||.. ||.
nednysnikfqfvgienihvmreslqkllevvelksksvseflsglessgwlkhikavldasifiakavaeegasvlvhcsdGwdrtaqvcslasllldp

HYRSIEGFKTLIEKEWLGFGHRFTQRCNQVESAQSGFTPVFLQFLDAVHQIMRQYPLSFEFNDHFLCTLAYHHVSMRFRTFLMDSEHERYQAGWmieeeg
.||.|.||. |||||||.|||.|..|| ......  ..|.|.|||..| |...|.| .||||..|| .|  |  | .| ||| ..|..| ..        
yyrtikGflvliekewlsfGhkfsercGlldedskevsPiftqflecvwqlleqfpkafefnerfllelhdhvyscqfGtflgncekdrrdlkl......

KRRGKSLWDYIDaqnQRSPAFYNFMYSPDNQ-KVLRPFCRISNLVVWK
|.| |||| |.    .|   . | .|..... .||.|  . ..| .|.
kertkslwayll...erkddylnplykaetekevlkpdtapaalklwr
subfamily_MTMR9_pd Subfamily MTMR9 1342-1588 4.1e-60 195.9 In-house 145-386 (393) alignment 
Range on Protein: 1342-1588
Range on HMM: 145-386/393.0
KQEAYPKCEFVPVELPDVRAVRACFKKFLRACCPATDSPISFVQQVNESEWLHQLSAVMNVSNVLVDLIDIQGSSVMVCFEDGWDVTAQVVCLAEICLDS
... |.. . .  .|  |. .   . |.| ||  |. |  .|......| ||.|. .......|.....| .|..|.|  |.| | | ||. || . ||.
tevkysqwkkasrslesvasiqdslaklleacsdaglstdkflsrleksgwlsqvadlleaalvvaqcldeegapvvvhgeeGlDatlqvtsLaqlildp

HYRSIEGFKTLIEKEWLGFGHRFTQRCNQVESAQ---SGFTPVFLQFLDAVHQIMRQYPLSFEFNDHFLCTLAYHHVSMRFRTFLMDSEHERYQAGwmIe
..| ..||. |||.||.  || |..|...|  ..      .|||| |||.|.||..|.|.|||||...| .|  |  | .| |||.|.|.|| ...  . 
daRtvrgfealiereWiqaGHPFasRaskvaaketkkklsgpvfllFLDcvyqilsqfpasFEFneelLillfehsyssqfgtflcdneaerkelk..l.

eegKRRGKSLWDYIdAQNQRSPAFYNFMYSPdNQKVLRPFCRISNLVVWK
   |.. .|||.|.  .... . | | .|.. |..|..|  .   |..|.
...kkktvslwsyv.nrpeklkqflnplyea.naeviwpsvapqslelWs
subfamily_Dicty-MTMR1-like_pd Subfamily Dicty-MTMR1-like 1344-1575 5.6e-60 195.6 In-house 152-375 (404) alignment 
Range on Protein: 1344-1575
Range on HMM: 152-375/404.0
EAYPKCEFVPVELPDVRAVRACFKKFLRACCPATDSPISFVQQVNESEWLHQLSAVMNVSNVLVDLIDIQGSSVMVCFEDGWDVTAQVVCLAEICLDSHY
. | .||     . ..  .|  .||.  |.  ....   . .....|.|| ... ....|. .|.||. ..|||.|   |||| |.|.. |....||..|
sryenceieflnienihelreslkklkkavnsiiekeknwlselessrWldhiklllegskriveliekekssvlvhcsdgwDrtsqlsslsqllldpyy

RSIEGFKTLIEKEWLGFGHRFTQRCNQ-VESAQSGFTPVFLQFLDAVHQIMRQYPLSFEFNDHFLCTLAYHHVSMRFRTFLMDSEHERYQAGWMIEeegk
| ||||. ||||||| ||| |.||..|  |  .. . |.||||.|.|.|...|.| |||||..|| .. ..  | || |||.|||.|| |.  . |    
rtiegFivliekewlsfGhkfaqRigqttekssdersPiflqFidcvyqltkqfptsFeFnekflikildalyscrfgtFLydsekeRqqnnlake....

rrGKSLWDYIDAQNqrsPAFYNFMYSPDNQKVL
   .||| ...|..     . | .|  ....  
..tvslWalleank...seylnplyilekkeqk
subfamily_MTMR10_pd Subfamily MTMR10 1355-1537 6.5e-41 132.3 In-house 122-314 (380) alignment 
Range on Protein: 1355-1537
Range on HMM: 122-314/380.0
ELPDVRAVRACFKKFLRACCPATDS-----PISFVQQVNESEWLHQLSAVMNVSNVLVDLIDIQGSSVMVCFEDGWDVTAQVVCLAEICLDSHYRSIEGF
||| .. | . ..|. . | . |          .. . ....||.  ..... .  .|...  .. ||..  ..| |.   |  || ..||.|||.|.||
elpsiqdvqkaylklreLcvidtseefvtlddkwlssLektrWLayvrlclstasdavktvvekkrsvilqesegrDlscvvaSLaqlmldphyrtisGf

KTLIEKEWLGFGHRFTQRCNQVESAQSGFTPVFLQFLDAVHQIMRQYPLSFEFNDHFLCTLAYHHVSMRFRTFLMDSEHERYQA-----GWMI
..||.|||   || |..|.... ....   |||| ||| |.| ..|.| .|||...|| .|  ...|  | |||..||..| .|       .|
qsliqkewvaaghpfldrlghikpseksespvfllFldcvdqlleqfpseFeFtetfLialwdsshsgifltflfnseeqrlkavvsssplli
DENN DENN (AEX-3) domain 131-282 3.1e-40 127.3 Pfam-A 1-152 (185) alignment 
Range on Protein: 131-282
Range on HMM: 1-152/185.0
YVPKTLCLVSAVTYFEILKNCLTTIYLAFVAGNEELLEKLVGSILGLVRVPPPGGPKLAFSIGAGDRQTLCPPLCDTIPVTGVSVSTVFHQIGIHNMLSL
..||.||..| . .||..|..|.... .   .... ||... ..|  | .|.|| .   .| .. ....|. |  ...|...|.....|....|.|.|.|
ripkalcilsrlpffelfkkiLkalekrlksssklplesfianlllevplPapgktlklkslsvkekillqrpssselPledvdleelfrcLsienvlql

FCAAVTENKILFISSSFVQLTTVTRAMLALMYPLKFSYVYIPILPAALLDFL
|.|...|..|...|...  ||.|..|..||.||||....|||.|||.|||.|
feavLlErriillSeklarLtsvaealvallyPlkWqhiyiPvlpaslldvl
subfamily_Ank-MTMR1_pd Subfamily Ank-MTMR1 1344-1588 1.1e-39 128.3 In-house 157-398 (405) alignment 
Range on Protein: 1344-1588
Range on HMM: 157-398/405.0
EAYPKCEFVPVELPDVRAVRACFKKFLRACCPAT------D-SPISFVQQVNESEWLHQLSAVMNVSNVLVDLIdIQGSSVMVCFEDGWDVTAQVVCLAE
  ||.| .| ...|..  .|  ..|.  |   ..      . . . |   ..|. |. .. .... . .  .|| ..| |..|   |||| | |.  |..
hnypncklvfmnipnihvirksleklvlamkssardkdhtestdmrfwgyieetgwishiksileaatfsaeli.lkgnsilvhcsdgwdrtpqitsltq

ICLDSHYRSIEGFKTLIEKEWLGFGHRFTQRCNQVESAQSGFTPVFLQFLDAVHQIMRQYPLSFEFNDHFLCTLAYHHVSMRFRTFLMDSEHERYQagwm
| || .||.| ||. ||||||| |||.|. |  ..   .   .|.| ||||.. |.. |.|| |||   .|  ..    | .. ||| . |..| |    
illdpyyrtivgfqvliekewlsfghkfslrlghlpgneeerspifqqfldccfqllsqfpllfeftpslllfisdnihsckygtflnncekdrvq....

ieEEGKRRGKSLWDYIDAQNQRspaFYNFMYSPDNQKVLRPFCRISNLVVWK
  .. | .  |.|  .. . ..   | |  | |.. . ..|      | .||
..dqvktktisiwsevnlnvnk...flnpyynpqdiqsikpklysrclelwk
subfamily_Dicty-MTMR1-like_pd Subfamily Dicty-MTMR1-like 1130-1209 1.8e-19 62.2 In-house 22-95 (404) alignment 
Range on Protein: 1130-1209
Range on HMM: 22-95/404.0
CQDYSRLGFGNILrasaggPWRISMVNYTYTVCRSYPAVVVVPQSISDDTVLRVAKNHRQNRFPVAIWKHPKNKATLVRA
 ..|.|||. .        .|||| .|. |..| .|| ..|||.||||. . .||.   ..|.||  |.|.....|..|.
eeEykRlgikses......eWriskinsdyelcetYPkllvvPesisDeelkkvasfRskgRiPvlswrhrsknstitRs
subfamily_MTMR9_pd Subfamily MTMR9 1145-1211 9.9e-19 59.7 In-house 29-95 (393) alignment 
Range on Protein: 1145-1211
Range on HMM: 29-95/393.0
SAGGPWRISMVNYTYTVCRSYPAVVVVPQSISDDTVLRVAKNHRQNRFPVAIWKHPKNKATLVRAGG
||   |||| ||  ..|| |||. |.||..|.|...  .|.  .. ||||  . | ..||.|.|.. 
sasdewRissvNknfkvcasypesvivPkaiddeelkasaafreggrfPvLsylhketkavllrssq
subfamily_MTMR3_pd Subfamily MTMR3 1125-1210 2.1e-18 59.4 In-house 25-104 (442) alignment 
Range on Protein: 1125-1210
Range on HMM: 25-104/442.0
SSMPCCQDYSRLGFGnilrasAGGPWRISMVNYTYTVCRSYPAVVVVPQSISDDTVLRVAKNHRQNRFPVAIWKHPKNKATLVRAG
...   ....||||         . |||| ||  . .|.|||  ..||.||.||.. .||.    .|.|. .|.| ||.| |.|..
aeeklkeeverlGfd......lkeawrisdvnsdfklCssyPkklivPksitdddlkkvasfrslkrlPavvwrhkkngavlarcs
subfamily_pats1_pd Subfamily pats1 1348-1473 1.3e-17 55.5 In-house 335-462 (691) alignment 
Range on Protein: 1348-1473
Range on HMM: 335-462/691.0
KCEFVPVELPDVRAVRACFKKFLRACCpATDSPISFVQQVNESEWLHQLSAVMNVSNVLVDLIDiQGSSVMVC-FEDGWDVTAQV---VCLAEICLDSHY
 .. . ..||    |...| ..|..     |.. .  ... || |.  .  ... .  .  |.| .||||..    |. ... ..     || . .| .|
ssniiflslPtrekveerffdllqsil.sldgsddewkeieeskwvdsvkllleaavkvsnlld.eGssvllknsidsPlieldlasisslaqvlsdPfy

RSIEGFKTLIEKEWLGFGHRFTQRCNQVES
|...||| ||||||| .|. |....   ||
rtldGfkvliekewlsyGfPfskinyhkes
subfamily_pats1_pd Subfamily pats1 1475-1570 2.3e-17 54.6 In-house 549-635 (691) alignment 
Range on Protein: 1475-1570
Range on HMM: 549-635/691.0
QSGFTPVFLQFLDAVHQIMRQYPLSFEFNDHFLCTLAYHHVSMRFRTFLMDSEHERyqagwmIEEEGKRRGKSLWDYIDaQNQrsPAFYNFMYSPD
. .|.|.|.||||.| |. ...|. ||||...| .|  .  | || .||..   ..       |..  .| ||.| .|. ||.    | |..| . 
nrsfsPifvqfldlvwqlqkefPfhfefneslllllvkesfssrfGnflyseakrd......serkvlkrsksiwsfin.qnk..srfinllykhs
dDENN dDENN domain 347-415 3.7e-17 51.5 Pfam-A 2-68 (68) alignment 
Range on Protein: 347-415
Range on HMM: 2-68/68.0
DKEIRAIFLRILAQTFAGYRSCLTLIRIHPKpvITFHKARFLEQRGMIGDDFFSKVLESMSFSQFVATR
|...|..||| .|....|||..|. .| .|.  ..|.|..||..|     .| |..||.. |..|. .|
dqqvreaFlrffasllggYrnflrkerkspe..vsFqkeaFlksrskshrsFlsqfletqmFaeFieer
subfamily_MTMR1_pd Subfamily MTMR1 1145-1210 3.7e-17 54.7 In-house 25-87 (389) alignment 
Range on Protein: 1145-1210
Range on HMM: 25-87/389.0
SaggPWRISMVNYTYTVCRSYPAVVVVPQSISDDTVLRVAKNHRQNRFPVAIWKHPKNKATLVRAG
     |||. .| .|..| .||||.|||...||... .||. . ..|.||. | ...|.|...|| 
k...lWritklnkkyelcdtYpavlvvpkvvsdedlkkvaafrskgRlPvlswlnkenqavilras
uDENN uDENN domain 24-86 8.5e-16 47.2 Pfam-A 1-65 (65) alignment 
Range on Protein: 24-86
Range on HMM: 1-65/65.0
KGKVLQRFPPQDR-KDVAFPEGIELFCQPTGWKTSYYC-RPQTFFVSVLTDMEGDHKYLACFTFY
|.|.|..||..|  .|  .|. |..||.| |..  .   ....||. ||||..|  .| .| .|.
kpkildqfPekdeeedeplpkaipmFCfPeglnfvtsreqkpeffsfvLTdedgsriyGfClrfl
GRAM GRAM domain 877-958 1.7e-13 41.3 Pfam-A 5-68 (69) alignment 
Range on Protein: 877-958
Range on HMM: 5-68/69.0
RPALLPGEEMLCNGLRCYLVPDgrelgrggevggptLLPAEGAAFLTNYRVIFKGTPVDQFAsemiVTRSFPVGSVVREKKI
..  ||.|| | . ..||| ..              ..|..|. .|||||.||.. ..|...    |....|.... | .|.
ktfklppeEkllddyaCylsts..............kgpvqGrlYlTnyrliFrSdklddsk....vvvvipladikrveks
PH PH domain 1735-1832 4.2e-12 36.5 Pfam-A 3-100 (104) alignment 
Range on Protein: 1735-1832
Range on HMM: 3-100/104.0
HCGYLHKRGHLFKQWKSRWFVLDTqrNQLRYYETRD---DPHCAGFIDLGEMiAVVPGNPLP-GapKGAEKGAFFDLRTTKR-VYNLLAEDQEATQEWIE
..|||.|...|.|.|| |.||| .  |.| |.. ..   .    | |.| ..  | .      |  .  |.   | ......  | | ||..|  ..|..
keGyllkksellktwkkryfvLts..nyLlyfksskkksykapkgsiplndc.tvkkasstkfg..aqkesnnyfeitfknvesyllsaeseeerkrWvq

KLQ
.|.
alk
subfamily_MTMR10_pd Subfamily MTMR10 1149-1211 5.5e-11 33.8 In-house 25-87 (380) alignment 
Range on Protein: 1149-1211
Range on HMM: 25-87/380.0
PWRISMVNYTYTVCRSYPAVVVVPQSISDDTVLRVAKNHRQNRFPVAIWKHPKNKATLVRAGG
 .. ...|   ... ..|  .|||.|.||. | |. . ... |||. .|.|.| .| |. .. 
aivvllknelfaaaqtlPqyfvvpnslsdsdverlsrhykesRfplwvwshakgaallrlsal
subfamily_pats1_pd Subfamily pats1 1129-1210 1.3e-10 32.3 In-house 5-84 (691) alignment 
Range on Protein: 1129-1210
Range on HMM: 5-84/691.0
CCQDYSRLGFGNILRASAGGPWRISMVnYTYTVCRSYPAVVVVPQSISDDTVLRVAkNHRQNRFPVAIWKHPKNKATLVRAG
. ..|| |  |. |. .    ||.  .     ..  ||  ..||...||. .   .  .|. ..||  | ...||..|.|  
ifdiyslliegqrlkldldkdwrvvef.lsrdlseiyPkrilvPklvsdellvsyv.rkrsskiPvlswsnqnnksslfric
subfamily_MTMR6_pd Subfamily MTMR6 1149-1209 1.1e-09 30.1 In-house 37-97 (397) alignment 
Range on Protein: 1149-1209
Range on HMM: 37-97/397.0
PWRISMVNYTYTVCRSYPAVVVVPQSISDDTVLRVAKNHRQNRFPVAIWKHPKNKATLVRA
 | .. .| .|..| .||  ..||.|.. ....  .|   ..|.||  . | .|.|.. |.
kwtltdlnkdyelcdtyprelyvPksatkevlvgsskfrskgrlPvlsylhkeneaaicrc
PH_11 Pleckstrin homology domain 1736-1771 4.9e-08 23.1 Pfam-A 2-38 (112) alignment 
Range on Protein: 1736-1771
Range on HMM: 2-38/112.0
CGYLHKRGHL-FKQWKSRWFVLDTqRNQLRYYET-RDD
.||| | |.  .| || |||.|    |.|.||.  ||.
kGylkkkgskllkgWkrrwfiLrk.dnvleYyksprdk
subfamily_Ank-MTMR1_pd Subfamily Ank-MTMR1 1132-1214 2.9e-07 21.6 In-house 24-110 (405) alignment 
Range on Protein: 1132-1214
Range on HMM: 24-110/405.0
DYSRLGFGNILRASAGGPWRISMVNYTYTVCRSYPAVVVVPQSISDDTVLRVAKNHRQNRFPVAIWKHPKNKATLVRAG----GIER
.| |.        |.   |... .|  | .| ||.. .|| .   |  . ..   . . | |   || |. .|.. |.     ||||
eylrfniyideenssncywkvtsinkeykmcssyssslvvlskaldkdlekifsfrskgripslswkdpssnasisrcsqplvgier
PH_3 PH domain 1731-1832 1.1e-06 17.3 Pfam-A 11-96 (104) alignment 
Range on Protein: 1731-1832
Range on HMM: 11-96/104.0
NKQLHCGYLHKRGHLFkqWKSRWFVLdTQRNQLRYYETRDDpHCAGFIDLGEMIAVVPGNplpgapkgaekGAFFDLRTTKRVYNLLAEDQEAtQEWIEK
.. | .|...||  ||   . |...| |....| | .   .  . |.| | ... |   |              | . | ||.|.|  ....| ..|...
elilkqglvkKrkglf..arkRqlll.tegPrLiyvDpekm.elkGeIplskelkvevkn...........skkFfihtpkrtyyledpesna.akWvka

LQ
..
ie
PH_8 Pleckstrin homology domain 1740-1832 1.7e-06 17.8 Pfam-A 4-86 (89) alignment 
Range on Protein: 1740-1832
Range on HMM: 4-86/89.0
H-KRGHLFKQWKSRWFVLDTQRNQLRYYETRDDPHCAGFIDLGEMIAVVpgNplpgapkgaEKGAFFDLRTTKRVYNLLAEDQEATQEWIEKLQ
. ||    . .. |.|||| .. .| ||..... .  | | | . |. .  |         |.   . . .  .|..| |....  |||.| |.
lkkrrkklqgyakRfFvLdlksstlsYyrddnssalrgkiplslaiisa..n.........eekreiiidsGaevWeLkasnekdfqeWveale