Gene Paladin in Nematostella vectensis

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family Paladin
Subfamily Paladin
Protein sequence
ID Type Fasta BLAST phosphatome Note
NvecP035_AA protein Get Run
NvecP035_AA_5-278 phosphatase_domain Get Run
NvecP035_AA_255-472 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_Paladin_pd Subfamily Paladin 3-260 5e-109 354.0 In-house 29-275 (314) alignment 
Range on Protein: 3-260
Range on HMM: 29-275/314.0
IKTGFPEHGLIQDKYFLIKDQFKGIDRLDTLKKYGAPNFRKASGsYPVYGMGQPSRDGLAVVIEELI--CRGHKEIVSFNLREEPVIflslNHDYIPYSP
 .  .||. |...||||..|.....|.|.|....|..||||..| .|||||.|||..||. |.|.|.  .|.|.|.|..|||||.|.    ..|...|||
aedvaPedllvrgkyflveDdlvslDvLstvrevgvaNFRkvpg.lpvyGmaQPsakglervleyLtdakrrhrevvvvnlReeavl....ecDgvtYsp

RDPNSLKGNIANYGVKPEELAETEIKIREEIIKlsieEGGKFYFYHDVDNFDNEPHSYNISYEEHVCVMDEIYSRQIFLTPFLRYSRVPITATNAPEEQD
|. ..|| |....||....|...||..|.||.|    .  ....|.||.....|.....|...|.|..|.|.||.|...||.|.|.|.|.....||.|.|
RekknlkenlpgkgvavddleklEiqlrkeilk....seneyevyadveelkeekeavlitrfetvltmeEvysqqlratptlsyhriplpeqkapleed

FDQFINAIKDIPQVIDVNSAaplPALIFNCHVGQGRTTTGMVIGCLIMCHRTGfPVADEE
.||.....|..|.... ...   |||.|.||.|.|||||.||...||..|..|  |..||
ldqllevlkevpsllskedg...palvFschsGkgrTttamvvavLillhkkG.evgeee
subfamily_Paladin_pd Subfamily Paladin 254-505 7.8e-96 310.7 In-house 44-314 (314) alignment 
Range on Protein: 254-505
Range on HMM: 44-314/314.0
FPVADEEFGMDVLSTQREVEVSNFRKVPGLPVYGMCQPNRKGLEKVIGLLTGPKYAHPRVVVVNLREDLVIDCDGETFSPRELKNISEHMPYKGL-----
| |.|. ...|||||.|||.|.|||||||||||||.||..||||.|.  ||..|..| .||||||||..|..|||.|.||||.||..|..|.||.     
flveDdlvslDvLstvrevgvaNFRkvpglpvyGmaQPsakglervleyLtdakrrhrevvvvnlReeavlecDgvtYspRekknlkenlpgkgvavddl

NS-------------AEIEVYVDVNSTHETRE------FSSVLTMREMFDEQMRRTPLLSYYRLPAPKDKAMEERDFDHLMNIVSSLEEIYTDEDGPALV
..             .|.||| ||....|..|      |..||||.|....|.|.|| |||.|.|.|..||..|.|.|.|.............|||||||
eklEiqlrkeilkseneyevyadveelkeekeavlitrfetvltmeEvysqqlratptlsyhriplpeqkapleedldqllevlkevpsllskedgpalv

FSCESGKERTTTAMVAACLIYCNKKGfpagtKPDEQDPACVPNAKYTLGEFSVIRHLMRVLPNGPQRKREVDYCLD
|||.|||.||||||| |.||...|||     .  |.. . ||.||.| .|| |. .....||.| . |.|||  ||
FschsGkgrTttamvvavLillhkkG.....evgeeelvsvpdakltkeefqvvmkvvqllpdGrrvkkevdaald
PTPlike_phytase Inositol hexakisphosphate 79-248 2.4e-36 119.6 Pfam-A 1-149 (149) alignment 
Range on Protein: 79-248
Range on HMM: 1-149/149.0
FNLREEPVIflslNHDYIPYSPRDPNSLKGNI-ANYGVKPEELAETEIKIREEIIKLSIEEGGKFYFYHDVDNFDnephsynisyeehV-------Cvmd
.|||||||.    . .  |...|... .. |. .  |...|||...| ...|...| . | .|....... ...              .           
inLReEpvv....yingrpfvlreqedelenlkeysgieaeeledlekrlkedvlkeaeeyegrilvhreteegv.............qktltevte...

EIYSRQIFLTPFLRYSRVPITATNAPEEQDFDQFINAIKDIPQvidvnsaapLPALIFNCHVGQGRTTTGMVIGCLIM
|.|..... .. ..| |.|||. .||||.|.|.|...||..|.          .||.|||. |.|||||.|||..|..
evyeeelaegfgvkYvRipitdeqapeeedvDafvrlikslpr.........dtalvfnCqaGrgRTTtamviadLlr
PTPlike_phytase Inositol hexakisphosphate 79-248 2.4e-36 119.6 In-house 1-149 (149) alignment 
Range on Protein: 79-248
Range on HMM: 1-149/149.0
FNLREEPVIflslNHDYIPYSPRDPNSLKGNI-ANYGVKPEELAETEIKIREEIIKLSIEEGGKFYFYHDVDNFDnephsynisyeehV-------Cvmd
.|||||||.    . .  |...|... .. |. .  |...|||...| ...|...| . | .|....... ...              .           
inLReEpvv....yingrpfvlreqedelenlkeysgieaeeledlekrlkedvlkeaeeyegrilvhreteegv.............qktltevte...

EIYSRQIFLTPFLRYSRVPITATNAPEEQDFDQFINAIKDIPQvidvnsaapLPALIFNCHVGQGRTTTGMVIGCLIM
|.|..... .. ..| |.|||. .||||.|.|.|...||..|.          .||.|||. |.|||||.|||..|..
evyeeelaegfgvkYvRipitdeqapeeedvDafvrlikslpr.........dtalvfnCqaGrgRTTtamviadLlr
0049772 (Phosphotyrosine protein) phosphatases II 6-253 1.2e-27 92.9 In-house 26-242 (314) alignment 
Range on Protein: 6-253
Range on HMM: 26-242/314.0
GFPEHGLIQDKYFLIKDQFKGIDRLDTLKKYGAPNFRKAsGSYPVYGMGQPSRDGLAVVIEELICRGHKEIVSFNLREEPVIFLSLnHDYI---PYSPRD
.. .. .......|. |.|...|.. .|. ..|.|.... ...||.|..... ...  .   ....|..||. ...|||||....  ....    . .||
nrrslsvlpeltilvadlflnrdknryldilpadnrvil.pglpvsgsdyinasyvdgflkfIatqgpleitvvdfreepvlyyng.wrmvlrgdlnvrd

PNS---------------------LKGNIANYgvkpeelaeteikireeiiklsieeggkfyfyhdvdnfdNEPHSYNISYEEhvcvmDEIYSRQIFLTP
.                       | .   |.                                       |||.  .. . .     .|.|... |  .
ivmsrdevladelsrLdaAlgKtpllildgng.......................................neptaadlellk.....eelydpelferl

FLRYSRVPITATNAPEEQDFDQFINAIKDIpqvidvnsaAPLPALIFNCHVGQGRTTTGMVIGCLIMCHRTG
 ..| |.|..  .|| ..|||.|...|..           .  .... |. | |||.| .|...|.....  
gikylripvpDgsaplledfdeflefieea.........dkggpvlvHCkaGkgRtgtfvvaaylmkllgvs
PTPlike_phytase Inositol hexakisphosphate 316-449 1.5e-27 91.0 Pfam-A 1-148 (149) alignment 
Range on Protein: 316-449
Range on HMM: 1-148/149.0
VNLREDLVIDCDGETFSPRELKNISEHM-PYKGLNSAEIEVYVD-----VNSTHETREFSSVL----------TMREM----FDEQMRRTPLLSYYRLPA
.||||. |....|..|..||... .|..  |.| ...|.|   .     |..  |. |   ..          |..|.    ..|.. ... ..|.|.|.
inLReEpvvyingrpfvlreqedelenlkeysgieaeeledlekrlkedvlkeaeeyegrilvhreteegvqktltevteevyeeelaegfgvkYvRipi

PKDKAMEERDFDHLMNIVSSLEEiytdedGPALVFSCESGKERTTTAMVAACLI
....|.||.|.| ......||..       .||||.|. |. ||||||| |.|.
tdeqapeeedvDafvrlikslpr......dtalvfnCqaGrgRTTtamviadLl
PTPlike_phytase Inositol hexakisphosphate 316-449 1.5e-27 91.0 In-house 1-148 (149) alignment 
Range on Protein: 316-449
Range on HMM: 1-148/149.0
VNLREDLVIDCDGETFSPRELKNISEHM-PYKGLNSAEIEVYVD-----VNSTHETREFSSVL----------TMREM----FDEQMRRTPLLSYYRLPA
.||||. |....|..|..||... .|..  |.| ...|.|   .     |..  |. |   ..          |..|.    ..|.. ... ..|.|.|.
inLReEpvvyingrpfvlreqedelenlkeysgieaeeledlekrlkedvlkeaeeyegrilvhreteegvqktltevteevyeeelaegfgvkYvRipi

PKDKAMEERDFDHLMNIVSSLEEiytdedGPALVFSCESGKERTTTAMVAACLI
....|.||.|.| ......||..       .||||.|. |. ||||||| |.|.
tdeqapeeedvDafvrlikslpr......dtalvfnCqaGrgRTTtamviadLl
0049772 (Phosphotyrosine protein) phosphatases II 256-453 5e-21 71.2 In-house 40-240 (314) alignment 
Range on Protein: 256-453
Range on HMM: 40-240/314.0
VADEEFGMDVLSTQREVEVSNFRKVPGLPVYGMCQPNRKGLEKVIGLLTGpkYAHPRVVVVNLREDLVIDCDGETFSPRELKN-----------------
||| ....|........ . |....|||||.|. ..| ...  .   .     ..  ..||..||. |. ..| ....|.  |                 
vadlflnrdknryldilpadnrvilpglpvsgsdyinasyvdgflkfIat..qgpleitvvdfreepvlyyngwrmvlrgdlnvrdivmsrdevladels

-------------ISEHMpyKGLNSAEIEVYVdvnsthetrefssvltmREMFDEQMRRTPLLSYYRLPAPKDKAMEERDFDHLMNIVSSLeeiytdEDG
             .....    .. |..| .                  .|..| .    . . |.|.| | . |  ..|||...... ..      ..|
rLdaAlgKtpllildgng..neptaadlellk.................eelydpelferlgikylripvpDgsaplledfdeflefieea......dkg

PALVFSCESGKERTTTAMVAACLIYCNK
 .... | .|| ||.|..|||.|.....
gpvlvHCkaGkgRtgtfvvaaylmkllg