Gene Auxilin in Nematostella vectensis

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTEN
Subfamily Auxilin
Protein sequence
ID Type Fasta BLAST phosphatome Note
NvecP037_AA protein Get Run
NvecP037_AA_387-570 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_Auxilin_pd Subfamily Auxilin 389-558 4.8e-84 273.1 In-house 1-166 (166) alignment 
Range on Protein: 389-558
Range on HMM: 1-166/166.0
MAGYVKNDLDLSYITSRIIVMSFPAEGIESTYKNNIDDVREFLEAKHYEQYFVVNVSPRNYRADKLSTRVLHQCWPVNRLPPLESIISLCRKIFVWLKKD
.|.|.|||||.||||||||||||||||.||||||||||||.|||..|.|.|.|.|.|.|.||..|||.||....||..|.|.|||....||....|||||
vasyakndlDisyitsriivmsfPaegvestyknniddvrsfLesrhpekylvynlsqrtyrtaklssrvveagwparraPnLeslvevcrnlyswlkkd

SSRVIVIHCMDGRVASGVLVSAFFVFCKLFKNPNGAADMFSIRRCGIGqkvaLTPSQERYLLYIAELINN
...|.|.||.|||.||.|||||..|||.|...|. |...||..|..||    |.||..||| |.|.|...
pknvvvvhckDGraasavlvsallvfcrllsepesavrlfsvkrlpig....lspsekryleyladllae
Pkinase Protein kinase domain 34-304 4.7e-53 169.9 Pfam-A 2-256 (260) alignment 
Range on Protein: 34-304
Range on HMM: 2-256/260.0
KIKRVIAEGGYGFVFVAQDGKTGKEYALKRLMAGDEAANKNI--LQEINMLKRLrGHPNVVQFYSAASLgekesghgMTEYLILTELCTGGEMIKILQer
.... . .|..| |. |.. ||||..|.|.|   .|  .|..  |.|...||.|  |||.|.....            .|.....|.. ||.. ..|.  
elleklGsGsfGkVykakekktgkkvAvKilkkeeekskkektalrElkilkkl.nHpnivkllevfee........kdelylvleyveggdlfdllk..

DGQPFSPDQILRIFYQLCRAVSHMHKQspPIIHRDLKIENMLIGSKGQIKLCDFGSATTEpltpddswtalnRSLAEDEIQRNTTPMYRAPEMVDlySNL
. ...| ..| .|..|........|..   ||||||| || |. .||..|..|||.| .              .  |.  ..  |. |.|||..   .. 
kkgklseeeikkialqilegleylHsn..giiHrDLKpeNiLldekgelkiaDFGlakkl............eksseklttlvgtreYmAPEvll..kak

PVTEKADIWALGCVLFYLCFMEHPFEDS---AKLRIINAKYT-IPEMDR-----EYTMYHDLINSTLVVHPEDRPCIRDILT
  |.|.|.|.||..|. |.. . ||...    .|..|... .   | |.     . ..  |||...|   |..|. ...||.
eytkkvDvWslGvilyelltgklpfsgeseedqlelirkilkkkleedepkssskseelkdlikkllekdpakRltaeeilk
subfamily_Tensin_pd Subfamily Tensin 394-570 1.3e-44 145.0 In-house 8-184 (189) alignment 
Range on Protein: 394-570
Range on HMM: 8-184/189.0
KNDLDLSYITSRIIVMSFPAEGIESTYKNNIDDVREFLEAKHYEQYFVVNVSPRNYRADKLSTRVLHQCWPVNRLPPLESIISLCRKIFVWLKKDSSRVI
| ||||.|||.|||..|||||| |..|..|. || ..|..|| ..| | |.| ..|  .||...||   || .  |.|| . |.|...  |||.|  .|.
kvdldltyiteriialsfpaegleekyrenlkdvakllkskhndkylvfnlsekrydisklnkkvldfGWPdllaPsleklcsicksldsWlkadpqnvv

VIHCMDGRVASGVLVSAFFVFCKLFKNPNGAADMFSIRRCGI-GQKVALTPSQERYLLYIAELINNpSMKPQKNSLYI
|.||  |.   ||.|||.  . |. .  . | | |...|      .  . ||| ||. |. .|... ..| . . |..
vvhckGgkgrigvvvsaymkyskisasadaaldrfamkrflddklsgetqPsqrryveyfsglLsg.kiklnssplfl
subfamily_PTEN_pd Subfamily PTEN 394-558 3.4e-42 139.5 In-house 17-181 (184) alignment 
Range on Protein: 394-558
Range on HMM: 17-181/184.0
KNDLDLSYITSRIIVMSFPAEGIESTYKNNIDDVREFLEAKHYEQYFVVNV-SPRNYRADKLSTRVLHQCWPVNRLPPLESIISLCRKIFVWLKKDSSRV
. ||||||||..||.|..|||..|..|.|...|| .||| || ..| . |. | |.| ..|...|| .     .  |||| . .....|  ||..|...|
gldLDlsyiteniiamgyPaeklealyRnsledvvkflekkhkdhykiynlrserkydskkfdgrvavypfdDhnppplelleeivediekwleedkknv

IVIHCMDGRVASGVLVSAFFVFCKLFKNPNGAADMFSIRRCGIGQKVAlTPSQERYLLYIAELINN
.|.||. |.  .|||..|... ..|..... | ..|.  |   .. |   ||| ||. |  .|...
vvvHCkaGkGRtGvlivayllkslllekaeealelfaeaRtknkkgvt.iPsqrRYveYyekllee
subfamily_VSP_pd Subfamily VSP 396-558 6.1e-35 115.1 In-house 33-200 (212) alignment 
Range on Protein: 396-558
Range on HMM: 33-200/212.0
DLDLSYITSRIIVMSFPAEGIESTYKNNIDDVREFLEAKHYEQYFVVNV-SPRNYRADKLSTRVLHQCWPVNRLPPLESIISLCRKIFVWLKKDSSRVIV
||||.|.| ||| ||||. | .| |.| |..|  ||. || ..| |||. | |.|    .  || .       .| || ........  ||.|| ..|..
dldltyvteriiamsfpssGkqslyrnpisevarfldtkhrdhykvvnlcseraydekyfnnrvkriliddhnvpkleellvftkevkewlekdlknvla

IHCMDGRVASGVLVSAFFVFCKLFKNPNGAADMFSIRRCGIGQK----VALTPSQERYLLYIAELINN
|||  |.  .| .| |...  ..|.. . . | |. ||   ..        ||||.||. |...... 
ihckGGkgrtGtivcalllaseifetakesldyfgerrtdktegekfqGvqtpsqkryvgyleqvktk
Pkinase_Tyr Protein tyrosine kinase 33-306 8.1e-35 110.1 Pfam-A 1-259 (259) alignment 
Range on Protein: 33-306
Range on HMM: 1-259/259.0
LKIKRVIAEGGYGFVFVAQDG----KTGKEYALKRLMAGDEAA-NKNILQEINMLKRLrGHPNVVQFYSAASlgE--KesghgmteYLILTELCTGGEMI
|.... ..|| .| |. ..      |.  . |.| | ...|   ....|.|....|.|  |.|.|... . .  .  .        .||.||...||.. 
lelgkklGeGafGeVvegtlkgekekkevkVavKtlkeeaeeeekeefleeakimkkl.khenivkllgvct..keep........llivteyvegGdLl

KILQERDGQPFSPDQILRIFYQLCRAVSHMHKQSppIIHRDLKIENMLIGSKGQIKLCDFGSATTEpltpddswtaLNRSLAEDEIQRNTTPMYRAPEMV
| |.... .... ...|.. .|............  ..||||   |.|. .....|..||| | .            ...  ... ....   . |||..
kfLrkkekekltledllsfalqiAkGmeyLeskk..lvHrdLaarNvLleenkvvkisDfGLardi..........ekddyykkkekaklpvkWmapEsl

DLYSnlpVTEKADIWALGCVLFYLCF-MEHPFEDSAKLR---IINAKYTIPEMDREYTMYHDLINSTLVVHPEDRPCIRDILTQL
.  .   .|.|.|.|. | .|. ..   |.|...  . .    ..... ... .   .  ..|... .  .||.|| .......|
kekk...ftsksDvWsfGvllwEiftlgespypglsneevleklkegkrlekpencpeelyelmkqCweeepekRptfkelvekl
PTEN_1 388-558 1.1e-32 108.5 In-house 11-194 (196) alignment 
Range on Protein: 388-558
Range on HMM: 11-194/196.0
SMAGYVKNDLDLSYITSRIIVMS-FPAEG-----IESTYKNNIDDVREFLEAKHYEQ-YFVVNVSPRN------YR---ADKLSTRVLHQCWPVNRLPPL
..  . ...|||.|||||||.|. .|...     .|..|.....||...|. .. .  ..|||.|..       |.   . |   ..||  ..    |.|
knlalptelldltyitsriiamgkapsrpllqeideglyrgslkdvaadldnlkedgitlvvnlseeeelsgrsydleeffksgveylhfpieDhgapsl

ESIISLCRKIFVWLKKDS-SRVIVIHCMDGRVASGVLVSAFFVFCKLfKNPNGAADMFSIRR-CGIGQkvalTPSQERYLLYIAELINN
....  |...  ||..|.  .|...||  |.  ||..| |. ....   ... | ... ..| .|  .    .|||||.| | ||| ..
selfdicksfiewllsdpngnvVlVHCkaGlgRsGtvvaayLmykgk.ltadeAlelvrekRppgapn....spsqerlleyfaellae
0036282 (Phosphotyrosine protein) phosphatases II 395-555 1.5e-24 82.1 In-house 8-168 (174) alignment 
Range on Protein: 395-555
Range on HMM: 8-168/174.0
NDLDLSYITSRIIVMSFPAEGIESTYKNNIDDVREFLEAKHYEQYFVVNVSPRN-YRADKLSTRVLHQCWPVNRLPPLESIISLCRKIFVWLKKDSSRVI
..|||||||.|.|....|.. .|  ....| .|  .|| |. . | . |  |.. .   .|  ..|.  || .  |.|. ...... .  .|..|.....
spldlsyitprliagqgplafwemlkelgittvvmlleekelglykcinywpelredlerlgiqylylpwpDhgvpdlsillefvkfveealsedpggpv

VIHCMDGRVASGVLVSAFFVFCKLFKNPNGAADMFSIRRCgIGQKVALTPSQERYLLYIAEL
..||. |.  .|.|| |. . . |. ..  | |..  .|     ..  |||| |.| |.  |
lVHCsaGvgRtGtlvaaylmlrglleslvdaldlvrelRl.qrpgmvqtpsQyrflyyfekl
PTEN_C2 C2 domain of PTEN tumour-suppressor protein 564-700 2.3e-23 73.8 Pfam-A 2-131 (134) alignment 
Range on Protein: 564-700
Range on HMM: 2-131/134.0
QKNSLYIKSVTLNPVPAFnKARNGCRPFIEMYQGNQRVLTTVQEIEKMREFTLSDGKVTFPVNLTLQGDVTIIVYHGRSTlggkvqgKMASMRVFLLQFH
.. .|..||..|...|.| | |.||.|... |.|.. | .. .. ....|    .  |..| .|...||| . ..| .|.       ..   ..| ..|.
npkrlelksiilegiPnf.ktrggckpkvkvyngkkkvfkelasykdsterraktfivkepnrlpveGDvlveflhkdsk.......lpkkekifrvwFN

TGFINPNATKLKYSREELDIAKED-VVKFSSRFAMTLD
| ||  | . |. ...||| | .|   |||. |...| 
TsFieknqnvltlpkneLDkalkdkdkkfsknfkvelv
0038934 (Phosphotyrosine protein) phosphatases II 401-569 3.3e-21 71.3 In-house 15-189 (194) alignment 
Range on Protein: 401-569
Range on HMM: 15-189/194.0
YITSRIIVMSFPAEG-----IESTYKNNIDDVREFLEAKHYEQYFVVNVS--PRNYRADKLSTR-VLHQCWPV---NRLPPLESIISLCRKIFVWLKKDS
.|| |.|....|..|     ||..|.....|. ..|...... . |....   | | ....  . . .  .|.   .  |.|| . . .. . ..|..|.
iitgrfiafkvPlsgsldkyieelyrfspedlvrylkllnvklglvidltnteryYdpeefekagieylklpfpddgtvPsleillrfldlvdeflnedp

SRVIVIHCMDGRVASGVLVSAFFVFCKLFkNPNGAADMFSIRRcgigQKVALTPSQERYLLYIAELINNPSMKPQKNSLY
. |...||. |.  .|.|| |. . .  . ... | ..|...|    ...  .... ..||   . ... .. |.|..|.
ggvvaVHCkaGlgRtGtlvaaYLiyrlgm.saeeAialfrekR....pgaipnqdyleallkrykelrkavlapekpell
0046846 (Phosphotyrosine protein) phosphatases II 395-554 1e-17 59.9 In-house 8-170 (176) alignment 
Range on Protein: 395-554
Range on HMM: 8-170/176.0
NDLDLSYITSRIIVMSFPAEGIESTYKNNIDDVREFLEAkhyEQYFVVNVSPRN-----------YRADKLSTRVLHQCWPVNRLPPLESIISLCRKIFV
 ||||.||. ..|..|.|. . ......  |......|.     . |||.  .             .  ||. ..||  || .  |.|| ...|.. |  
ldldldyinanlilgsrpiatqgplprtladflemlkel...gitavvnlteevelgrlkcpnywpeleklgiqylhlpwpDhgvpdlelllellefire

WLKKDssRVIVIHCMDGRVASGVLVSAFFVFCKLFKNPNGAADMFSIRRCGigqKVALTPSQERYLLYIAE
.||..  .....||. |.  .|.|| |. . .. . ... | ...  .|.    ..  ||.| |.| . . 
alkeg..gpvlVHCsaGigRtgtlvaayllelekglsveealalvreqRpl...gavqtpeQyrflyefel
0041856 (Phosphotyrosine protein) phosphatases II 393-552 1.7e-17 59.1 In-house 13-166 (182) alignment 
Range on Protein: 393-552
Range on HMM: 13-166/182.0
VKNDLDLSYITSRIIVMSFPAEGIESTYKNNIDDVREFLEAKHYEQY-FVVNVSPRNYRADKLST---RVLHQCWPVNRLPPLESIISLCRKIFVwlkkd
. ...||.||. .....|.||  .. |. . ...| .||.  . ...  .||.....| ...|     ..|.  || .  |.|..........       
ydhsrdldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlteelywpellerlgiqylylpwpDhgvpdldelldfieevle.....

SSRVIVIHCMDGRVASGVLVSAFFVFCKlFKNPNGAADMFSIRRCGigqkVALTPSQERYLLYI
.......||. |.  .|.|| |... ..   ..  | ...  ||.|    .  ||.| ..| ..
eggpvlVHCsaGvgRtgtlvaaylmkkl.gvsleeavklvrsrRpg....mvitpnqyfflqla
0039614 (Phosphotyrosine protein) phosphatases II 394-552 2.2e-17 58.9 In-house 80-284 (297) alignment 
Range on Protein: 394-552
Range on HMM: 80-284/297.0
KNDLDLSYI-----------TSRIIVMSFPAEG-----IESTYKNNIDDVR----------------------------EFLEAKHYEQYFVVNVSPRNY
. |||..||           | ..|....| ..     ..  .....  .                             ..|. .|.. |.| . . .|.
gvdldsdYinAsyvdgydlltrkfIatqgPlpetvedFwrmvweqgvtvivmLtklvelgrkcaqywpeeggtygdftvtllkvehldgytvrtlevtnn

RADKLSTRVLHQCWPVNRLPP-LESIISLCRKIFVWLKKD-SSRVIVIHCMDGRVASGVLVSAFFVF----CKLFKNPNGAADMFSIRRcgigQKVALTP
   .  |.... .|| .  || ||.........  .|... .......||..|   .|... |. ..    ..   ..  | ...  .|     ..  ||
gesrtvthfqytgwpdhgvppslellleflelvrealaelpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqR....pgavqtp

SQERYLLYI
|| |.| ..
sqyrflyda
0037934 (Phosphotyrosine protein) phosphatases II 396-552 6.8e-17 57.3 In-house 36-237 (243) alignment 
Range on Protein: 396-552
Range on HMM: 36-237/243.0
DLDLSYITSRIIVMSFPAEGIEST---------YKNNIDDVR----------------------------EFLEAKHYEQYFVVNVSPRN---YRADKLS
...|.|.| |.|....| ..             ....|. .                             ..|. .|...| | ... .|   .   .| 
nanliyvtprliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywpgevtygdftvtllseehlddytvrtlllenldlddltrlv

TRVLHQCWPVNRLPP-LESIISLCRKIFVWLKK-------DSSRVIVIHCMDGRVASGVLVSAFFVFCKLFKNPNGAADMFSIRRCGigqKVALTPSQER
..... .|| .  |.  |.........  ....       ||......||. |.  .|.|. |. .  .|  ..  | ...  .|.|   |.  |||| |
ihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRtGtliaaylmllllgvdleeavkllreqRpg...kavqtpsqyr

YLLYI
.| ..
flyea
0043147 (Phosphotyrosine protein) phosphatases II 395-554 1.5e-15 52.8 In-house 11-158 (172) alignment 
Range on Protein: 395-554
Range on HMM: 11-158/172.0
NDLDLSYITSRIIVMSFPaegiestYKNNIDDVREFLEAKHYEQyfVVNVSPR---NYRADKLSTRVLHQCWPVNRLPPLESIISLCRKIFVWLKKDSSR
..|||.||. |.|.. .|       . |...|....|  ..     .||. ..    .   .|  ..|.  || .  |.|| ...... |  .| .... 
syldlyyipdrfiatqgp.......lrntladfwrmlkelgith..ivnltellydpellerlgiqylylpwpDhgvpllellleflefidellalspgg

VIVIHCMDGRVASGVLVSAFFVFckLFKNPNGAADMFSIRRcgigQKVALTPSQERYLLYIAE
....||. |   .|.|| |. .   |  ..  | ...  .|     ..  .||| |.|.| ..
pvlVHCsaGvgRtgtlvaaylml..lglsleeavalvrekR....pgavqnpsqyrflyyfek
0042113 (Phosphotyrosine protein) phosphatases II 395-552 6.2e-14 47.5 In-house 33-238 (245) alignment 
Range on Protein: 395-552
Range on HMM: 33-238/245.0
NDLDLSYI----------TSRIIVMSFPAEGIES-----TYKNNIDDVR------------------------------EFLEAKHYEQYFVVNVSPR--
.|||..||          | ..|....|...         ....|  .                               ..|. .|.. | | ...    
gdldsdyinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywplgesltygdftvtllseehlddytvrtlevtnl

NYRADKLSTRVLHQCWPVNRLPP-LESIISLCRKIFVWLKKDSSRVIVIHCMDGRVASGVLVSAFFVF----CKLFKNPNGAADMFSIRRcgigQKVALT
 .   .  .....  || .  |. ||....... .  .|..||. ....||..|.  .|... |. ..      |  ..  | ...  .|     ..  |
gddesrevihyhylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylmleqlekelgvsleeavkelrsqR....pgavqt

PSQERYLLYI
||| |.| ..
psqyrflyea
0043336 (Phosphotyrosine protein) phosphatases II 393-552 9.9e-14 46.9 In-house 67-272 (278) alignment 
Range on Protein: 393-552
Range on HMM: 67-272/278.0
VKNDLDLSYI----------TSRIIVMSFPAEGIESTYKNNIDDVR----------------------------------EFLEAKHYEQYFVVNVSP--
...|||..||          . ..|....| .. .  . . . . .                                  ..|. .|.. | | .     
lggdldsdYinAsyvdgynvprkfiatqgPlpetvedFwrmvwelgvttivmLtelvelgrvkcaqYwpggsltygdftvtllkeehlddytvrtlevtn

RNYRADKLSTRVLHQCWPVNRLP-PLESIISLCRKIFVWLKkDSSRVIVIHCMDGRVASGVLVSAFFVF----CKLFKNPNGAADMFSIRRcgigQKVAL
. .   .  |.. . .|| . .| .|..........  .|. ||. ....||..|   .|... .. ..      .. ..  | ...  .|     .   
lgdgesrtvthyhylgwpdhgvpeslsllldflkavreale.dsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqR....pgavq

TPSQERYLLYI
|||| |.| ..
tpsqyrflyea
0046845 (Phosphotyrosine protein) phosphatases II 393-552 1.8e-13 46.0 In-house 65-269 (284) alignment 
Range on Protein: 393-552
Range on HMM: 65-269/284.0
VKN-DLDLSYITSRIIVMSFPAEG-----------------------------IESTYKNNIDDVREF-------LEAKHYEQYFVVNVSPRNYRADKLS
|.  ||||.||. ..|....| ..                               . | .....| ..       |. .... | | ... .|.  .. |
vdgydldltyikkkfIatqgPlpntvedFwrmvweqnvrvIVmltelvengrekcaqYwplegevltygdftvtllseevkddytvrtleltnlgytges

TRVLHQC---WPVNRLPP-LESIISLCRKIFVWLKK-DSSRVIVIHCMDGRVASGVLVSAFFVFCKLFKNP-------NGAADMFSIRRCGigqkVALTP
 .| | .   || .  || .|......|..  .|.. ... .||.||..|   .|... .  ... | |.         .|  ..  .|.|       |.
rtvthfhytswpdhgvppspedlleflrlvrellenlpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpg....mvqtl

SQERYLLYI
.| |.. ..
eqyrfvyea
0045450 (Phosphotyrosine protein) phosphatases II 400-552 2.1e-13 46.1 In-house 108-299 (307) alignment 
Range on Protein: 400-552
Range on HMM: 108-299/307.0
SYI----------------------------------TSRIIVMSFPAEGIESTYKNnidDVREFLEAKHYEQYFVVNVSPRNYRADKLSTRVLHQCW--
 .|                                  ....... .| || | ||.|   .. ..|. .|.. | | ..   ... .. | .| | ..  
kfIatqgPlpetvedFwrmlweqgvtvivmltelvelgrekcaqywPdegeeltygn...ftvtllseehldgytvrtlevtdldgtgesrtvthfhytg

-PVNRLPP-LESIISLCRKIFVWLKKD-SSRVIVIHCMDGRVASGVLVSAFFVFCKLF-------KNPNGAADMFSIRRCGIGQkvalTPSQERYLLYI
 |   .|| .|.........  .|... .. ....||..|   .|... |. . . |         ..  | ...  .|.|. |    .|.| |.| ..
wpdhgvppsfeelldfieevrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavq....npeqyrflyea
0051082 (Phosphotyrosine protein) phosphatases II 395-550 5.8e-13 44.2 In-house 4-145 (151) alignment 
Range on Protein: 395-550
Range on HMM: 4-145/151.0
NDLDLSYITSRIIVMSFPAEgiestyknnidDVREFLeaKHYEQYFVVNVSPRN---YRADKLST---RVLHQCWPVNRLPPLESIISLCRKIFVWLKKD
. ...||.|........| .           |. |.|  |..  . .||. .     | .. |     .|||  .. .  |.|. ..  ..... .| ..
dyinfsyvtgglyrsggpla...........dflell..kelgiktivnlrseeergycpeylpelgievlhipildwpdpglplsfdavleflellldk

SSRVIVIHCMDGRVASGVLVSAFFVFCKlfKNPNGAADMFSIRRCgigqkVALTPSQERYLL
.. ....||. |.  .|.|| .. . ..   ... | ... ..|.      . .|.|.....
kngpvlvHCsaGkgRTGtlvalylmllg..vsleealeeyrlkrp.....gvvqpnqqflfq
0048076 (Phosphotyrosine protein) phosphatases II 411-554 3e-12 41.9 In-house 3-140 (145) alignment 
Range on Protein: 411-554
Range on HMM: 3-140/145.0
FPAEGIESTYKNNIDDVREFLEAKHYEQYFVVNVSPRNYRADKLSTRVLHQCWPVNRLPPL-ESIISLCRKIFVWLKKDssRVIVIHCMDGRVASGVLVS
.|.| ... | ... ..... . |..  . |.|...  .   .| ...|.  || .  |.| | ...... |  .||..  .....||. |.  .|.|| 
wpseilpglylgslptaldlellkdlgittvlnltselellerlgiqylylpwpDhgvpdllellleflefieealkeg..gpvlVHCsaGvgRtgtlva

AFFVFCkLFKNPNGAADMFSIRRCGigqkVALTPSQERYLLYIAE
|. ... |  ..  | ...  .| |    .  .|.| |.|..  .
aylmll.lgvsleealelvrsqrpg....avpnpgqlrflyefel
0045098 (Phosphotyrosine protein) phosphatases II 396-553 3.1e-12 41.9 In-house 6-268 (278) alignment 
Range on Protein: 396-553
Range on HMM: 6-268/278.0
DLDLSYITSRIIVMSFPAEGIESTYKNNID----------------------------------------------------------------------
.|||.... .......| |  .. | .|.|                                                                      
sldlllefefllllgipseitpalylgnldknRykdilpydhsrVkdYINAsyidgypkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrek

---------------------DVREFlEAKHYEQYFVVNVSPRNYRADKLSTRVLHQ-CWPVNRLPPLE---SIISLCRKIFVWLK------------KD
                     .. .. .  ..  . |.|.. . .   ..  ..||  .|| .  |.|.   |...|.. |  .||             |
caqywpeggsltygdftvtllseevl.ddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllld

SSRVIVIHCMDGRVASGVLVSAFFVFCKL--FKNPNGAADMFSIRRCG-IGQkvalTPSQERYLLYIA
|. ....||. |   .|.|| |. . . |    ..  | ...  .|.| . |    ...| |.| . .
sggpvlVHCsaGvgRtGtlvaaylmlelleggvdlleavkelrsqRpglavq....nleqyrflyefl
0048179 (Phosphotyrosine protein) phosphatases II 411-552 4.1e-12 41.5 In-house 3-140 (144) alignment 
Range on Protein: 411-552
Range on HMM: 3-140/144.0
FPAEGIESTYKNNIDDVREFLEAKHYEQYFVVNVSPRNYRADKLST--RVLHQCWPVNRLPPL-ESIISLCRKIFVWLKKDssRVIVIHCMDGRVASGVL
.|.| ... | ... ..... . |..  . |.|...  . ..   .  ..||  || .  |.| | ...... |  .|...  .....||. |.  .|.|
npseilpglylgslptaldlellkklgittvinlteeyepefleregiqylhlpwpDhgvpdllellleflefieealeeg..gpvlVHCsaGvgRtgtl

VSAFFVFcKLFKNPNGAADMFSIRRCGIGQkvalTPSQERYLLYI
| |. .. ||  ... | ...  ||.|. .    .|.| |.||. 
vaaylmk.klglsleealalvrsrrpgavp....npgqlrfLley
0040438 (Phosphotyrosine protein) phosphatases II 393-570 6.4e-12 40.8 In-house 65-290 (317) alignment 
Range on Protein: 393-570
Range on HMM: 65-290/317.0
VKNDLDLSYI----------TSRIIVMSFPAEG-----IESTYKNNIDDVREFLEAK------------------------------HYEQY--FVVNVS
...|||..||          . ..|....| ..     ..  .....  .  . | .                              ... .  ... |.
lggdldsdYInAsyvdgpnlkrkfIatqgPlpntvedFwrmvweqgvtvivmLteleelgrekcaqYwplgetltygdftvtllseeelagitlrtleve

PRNYRADKLSTRVLHQCWPVNRLPP-LESIISLCRKIFVWLKkDSSRVIVIHCMDGRVASGVLVSAFFVF----CKLFKNPNGAADMFSIRRcgigQKVA
. .       |   .  ||   .|| ...........  .|. |.. ....||..|   .|... |. ..     . . ..  | ...  .|     .. 
dlgdsesrtvthfhytgWpdhgvppspdllldfleavreale.dpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqR....pgav

LTPSQERYLLYI-AELINNPSMKPQKNSLYI
 ||.| |.| .. .|....  ...  ..|. 
qtpeqyrflydalleylkrkltlepaselkl
0049260 (Phosphotyrosine protein) phosphatases II 407-555 7.1e-12 40.7 In-house 5-148 (152) alignment 
Range on Protein: 407-555
Range on HMM: 5-148/152.0
IVMSFPAEGIESTYKNNIDDVREFLEAKHYEQYFVVNV-SPRNYRADKLSTRVLHQCWPVNRLPPLESIISLCRKIFVWLKKDSSRVIVIHCMDGRVASG
. |.|.. . . .. |...|. ..|   .   . ...  .....   .   ..||  || .  |.|. ..  . ..  .|..|.. ....||. |   .|
yampfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyiqylhlpwpDhgvpdlsqlllflllfieklaldkggpvlVHCsaGvgRtg

VLVSAFFVFckLFKNPNGAADMFSIRRcgigQKVALTPSQERYLLYIAEL
.|| |. .   |  ..  | ...  .|     ..  .|.| |.|.. ..|
tlvaaylml..lgvsleeavalvrekR....pgavpnpgqlrflyefekl
0040439 (Phosphotyrosine protein) phosphatases II 396-552 8.1e-12 40.7 In-house 46-241 (249) alignment 
Range on Protein: 396-552
Range on HMM: 46-241/249.0
DLDLSYITSRIIVMSFPAEGIESTYKNNIDDVR-----------------------------------EFLEAKHYEQYFVVNVSPRN-YRADKLSTRVL
 .|..||. |.|....| ..  . . . . . .                                   ..|. .... | | ..   | |  ...  ...
yidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywplggsleygdftvtllsvevkddytvrtleltnlydgesrtvlhi

HQ-CWPVNRLP-PLESIISLCRKIFVWLKKD-SSRVIVIHCMDGRVASGVLVSAFFVF----CKLFKNPNGAADMFSIRRCGigqkVALTPSQERYLLYI
.   ||   .|  .|.........  .|... .. ....||..|   .|... |. ..     .|  ..  | ...  .|.|    .  .|.| |.|...
qytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaaylmleqlekelgvdleeavkllrsqRpg....avqnpeqyrflyea
0044763 (Phosphotyrosine protein) phosphatases II 396-556 2e-11 39.3 In-house 20-170 (178) alignment 
Range on Protein: 396-556
Range on HMM: 20-170/178.0
DLDLSYITSRIIVMSFPAegiestyknniDDVREFLeaKHYEQYFVVNVSP---------RNYRADKLSTRVLHQCWPVNRLPP-LESIISLCRKIFVWL
 ...|.|. .....|.|.            | .|.|  | .    .||...           |  .. . ..||  .| .  |. || .  ... |  .|
yinaseilpglylgslpp...........addlell..kelgithivnlteelelgflkcdpywpeeagiqylhipipDhgvpdllehflefvefieeal

KkDSSRVIVIHCMDGRVASGVLVSAFFVFCKLFkNPNGAADMFSIRRcgigQkVALTPSQERYLLYIAELI
. .. .....||. |.  ||.|| |. . .  . ... | ...  ||      .  .|.| |.|..... .
d.ekggpvlVHCsaGvgRsgtlvaaylmkklgl.sleeaielvrerR....p.ivpnpgqlrqLyefelrl
DnaJ DnaJ domain 1273-1316 2.4e-10 29.3 Pfam-A 13-54 (64) alignment 
Range on Protein: 1273-1316
Range on HMM: 13-54/64.0
QPDQVKKAYRKAVLCVHPDKLTGEPheALARAIFMELNEAWSLF
  ...|||||| .| .||||  ...  . |   | |.|||..  
sdeeIkkaYrklalkyHPDknkdde..eeaeekfkeineAyevL
0047943 (Phosphotyrosine protein) phosphatases II 434-551 2.3e-09 32.6 In-house 145-266 (273) alignment 
Range on Protein: 434-551
Range on HMM: 145-266/273.0
KHYEQYFVVNVSPR--NYRADKLSTRVLHQCWPVNRLP-PLESIISLCRKIFVWLKKD-SSRVIVIHCMDGRVASGVLVSAFFVF----CKLFKNPNGAA
.... | | ..  .  ..   .  | ...  || .  |  |||........  .|... |. ..|.||..|   .|... .. ..    ..   ..  | 
etkddytvrtleltnlgtgesrtvthfhytgwpdhgvppslesllefielvrkalealpsngpvvVHCsaGvgRtgtfialdllldqlekeggvdvleav

DMFSIRRCGigqkVALTPSQERYLLY
 ..  .|.|    .  ||.| |.| .
kllrsqRpg....mvqtpeqyrflye
0051299 (Phosphotyrosine protein) phosphatases II 431-548 1.8e-08 29.7 In-house 154-277 (288) alignment 
Range on Protein: 431-548
Range on HMM: 154-277/288.0
LEAKHYEQYFVVNVSPRNYR---ADKLSTRVLHQC---WPVNRLPP-LESIISLCRKIFVWLKkDSSRVIVIHCMDGRVASGVLVSAFFVFCKLFKNpnG
|. .... | | ..  .|..    |. | .| | .   || .  |. .|......|..  .|. ... ..|.||..|   .|... .. ... | |.  |
lseevlddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpdspellldflrlvrkala.sgggpvvVHCsaGvgRtgtfialdllleqleke..g

AADMFSIRRCGIGQK--VALTPSQERY
  |.... .    |.  .  ||.| |.
gvdvleavkrlreqRpgmvqtpeqyrf
0036941 (Phosphotyrosine protein) phosphatases II 432-551 3.8e-08 28.5 In-house 130-271 (297) alignment 
Range on Protein: 432-551
Range on HMM: 130-271/297.0
EAKHYEQYFVVNVSPRNYRADKLSTRVL-----------------HQCWPVNRLPP-LESIISLCRKIFVWLKKD-SSRVIVIHCMDGRVASGVLVSAFF
| . |....| ..|   .  |   .|.|                 .  || . .|.  .|........  .||.  |. ....||..|   ||... |. 
esltygdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfielvrkvlkllpsggpvlVHCsaGvgRsgtfiaadl

VFCKLFKN-P------NGAADMFSIRRCGigqkVALTPSQERYLLY
... | ..          |  ..  .|.|    .  |..| |.| .
mlqqledklkeggvdileavkklReqRpg....avqtleqyrflye
0049772 (Phosphotyrosine protein) phosphatases II 401-554 1e-07 27.5 In-house 118-275 (314) alignment 
Range on Protein: 401-554
Range on HMM: 118-275/314.0
YITSRIIVM---------------------SFPAEGIEstyknNIDDVREFLEAKhyeqyfvvnvsPRNYRADKLSTR-VLHQ--CWPVNRLPPLESIIS
 . .|.|||                       .. |       |. ..... . |           .. | ..... . . .    .| .  |.|| . .
dlnvrdivmsrdevladelsrLdaAlgKtpllildgng.....neptaadlellk...........eelydpelferlgikylripvpDgsaplledfde

LCRKIFVWlkkDSSRVIVIHCMDGRVASGV-LVSAFFVFCKLFkNPNGAADMFSIRRCgIGQKVALTPSQERYLLYIAE
... |  .   |  .....||..|.  .|. .| |. . .  . ... | ...  .|  |. .  . ...|.|. .   
flefieea...dkggpvlvHCkaGkgRtgtfvvaaylmkllgv.sleealedvrlkRp.inpnpgfieqleqyefilea
Kinase-like Kinase-like 146-266 1.6e-07 19.7 Pfam-A 153-261 (289) alignment 
Range on Protein: 146-266
Range on HMM: 153-261/289.0
YQLCRAVSHMHKQSppIIHRDLKIENMLIGSKGQIKLCDFgsattEPLtpddsWTALNRSLAeDEIQRNTTPMYRAPEM--VDLySNLPVTEKADIWALG
 || | . .....   ..| ... .|.|.  ||...| .|     ..|     ..| ..  .  |... ..|     |        .. .|.| | |.||
lqlirlaanLqarg..lvhgkispdnflldekggvfLggf.....taL.....vragkkvvv.sevekalaPpellaekggyts.nttkmthkldaWqlG

CVLFYLCFMEHPFEDSAKLRIIN
 |....  .. ||. .|.  ...
lviysiwclrlPftllaeeasee
0050432 (Phosphotyrosine protein) phosphatases II 432-538 1.8e-07 26.3 In-house 161-278 (308) alignment 
Range on Protein: 432-538
Range on HMM: 161-278/308.0
EAKHYEQYFVVNVSPRNyrADKLSTRVLHQ-----------------CWPVNRLPP-LESIISLCRKIFVWLkkdSSRVIVIHCMDGRVASGVLVSAFFV
. ..|....| ..|  .   |   .|.|.                   ||    || .|.........  .|   .. .||.||..|   .|... .  .
gsleygkftvtllseev..lddytvrtleltnlgdgesrtvthfhytnWpdhgvPpspeilldflelvrksl...pggpivVHCsaGvGRtGtfialdll

FCKLFKNpnGAADMFSIRRCGIGQK
.. | |.  |  |.|.. .    |.
leqleke..ggvdvfeavkklReqR
PTPc_DSPc_SM00012 460-552 6.3e-06 21.7 In-house 7-100 (105) alignment 
Range on Protein: 460-552
Range on HMM: 7-100/105.0
HQCWPVNRLPP-LESIISLCRKIFVWLKKDS-SRVIVIHCMDGRVASGVLVSAFFVFCKLFKNPnGAADMFSIRRCGIGQKVALTPSQERYLLYI
.  ||   .|   .||..|.|..  . .| . |  .|.|| .|   .|..| .  . ..| |.  .  |.| | .    |.  .  ..| ||  .
ytgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleket.kevdifqivkelrkqRpgmvqteeqylfly
Y_phosphatase Protein-tyrosine phosphatase 437-550 7.5e-06 20.9 Pfam-A 114-228 (235) alignment 
Range on Protein: 437-550
Range on HMM: 114-228/235.0
EQYFVVNVSPRNYRADK---LSTRVLHQCWPVNRLP-PLESIISLCRKIFVWLkKDSSRVIVIHCMDGRVASGVLVSAFFVFCKLFKNPNgaADMFSIRR
..| . ... ..  ...     . . .. || . .|   .|...|.||.  .  ...|  .|.||..|   .|..|.. .....| .. .   |...| .
keytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkveksk.eaksgpvvVhCsaGvgRtgtfvaldilleqleaeee..vdvlqivk

CGIGQKVALTPSQERYLL
    |.  .  | | |  
elRkqRpgmvqsleqYif
Y_phosphatase Protein-tyrosine phosphatase 437-550 7.5e-06 20.9 In-house 114-228 (235) alignment 
Range on Protein: 437-550
Range on HMM: 114-228/235.0
EQYFVVNVSPRNYRADK---LSTRVLHQCWPVNRLP-PLESIISLCRKIFVWLkKDSSRVIVIHCMDGRVASGVLVSAFFVFCKLFKNPNgaADMFSIRR
..| . ... ..  ...     . . .. || . .|   .|...|.||.  .  ...|  .|.||..|   .|..|.. .....| .. .   |...| .
keytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkveksk.eaksgpvvVhCsaGvgRtgtfvaldilleqleaeee..vdvlqivk

CGIGQKVALTPSQERYLL
    |.  .  | | |  
elRkqRpgmvqsleqYif