Gene PTEN in Nematostella vectensis

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTEN
Subfamily PTEN
Protein sequence
ID Type Fasta BLAST phosphatome Note
NvecP038_AA protein Get Run
NvecP038_AA_1-187 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_PTEN_pd Subfamily PTEN 4-183 8.2e-89 291.4 In-house 2-181 (184) alignment
Range on Protein: 4-183
Range on HMM: 2-181/184.0
FKQLVSKKKRRFQEDGFDLDLTYIKPNIVAMGFPSEKLEGVYRNHMDEVYRFLEQKHKDSYKVYNLCSERQYDPMRFHNRVATYPFDDHNAPPFELIKPF
....|||||.||.|||.||||.||..||.|||.|.||||..|||....|..|||.||||.||.|||.|||.||  .|..|||.|||||||.||.||....
lrkivskkkkrfkedgldLDlsyiteniiamgyPaeklealyRnsledvvkflekkhkdhykiynlrserkydskkfdgrvavypfdDhnppplelleei

CDDVDEWLKASNLNVAIIHCKAGKGRTGVMICAYLLHNGHFKDTKEAMEYYGNARTRNAKGVTIPSQRRYVEYYGYLLRN
..|...||.... ||...|||||||||||.|.||||.........||.|.. .|||.|.|||||||||||||||  ||..
vediekwleedkknvvvvHCkaGkGRtGvlivayllkslllekaeealelfaeaRtknkkgvtiPsqrRYveYyekllee

subfamily_VSP_pd Subfamily VSP 5-186 3.1e-67 220.6 In-house 17-203 (212) alignment
Range on Protein: 5-186
Range on HMM: 17-203/212.0
KQLVSKKKRRFQEDGFDLDLTYIKPNIVAMGFPSEKLEGVYRNHMDEVYRFLEQKHKDSYKVYNLCSERQYDPMRFHNRVATYPFDDHNAPPFELIKPFC
..|||. |||...|||||||||.   |.|| |||   . .||| ..|| |||..||.| |||.||||||.||.  |.|||     |||| | .| .  |.
rrlvsenkrrytqdGfdldltyvteriiamsfpssGkqslyrnpisevarfldtkhrdhykvvnlcseraydekyfnnrvkriliddhnvpkleellvft

DDVDEWLKASNLNVAIIHCKAGKGRTGVMICAYLLHNGHFKDTKEAMEYYGNARTRNA-----KGVTIPSQRRYVEYYGYLLRNCLT
 .| |||.. . || .|||| |||||| ..||.||. . |. .||...|.|. || ..     .||  |||.|||.|.  .     .
kevkewlekdlknvlaihckGGkgrtGtivcalllaseifetakesldyfgerrtdktegekfqGvqtpsqkryvgyleqvktkynr

PTEN_1 9-182 2.7e-47 156.1 In-house 7-193 (196) alignment
Range on Protein: 9-182
Range on HMM: 7-193/196.0
SKKKRRFQEDGFDLDLTYIKPNIVAMG-FPSEK-----LEGVYRNHMDEVYRFLEQKHKDS-YKVYNLCSERQ-----YDPM-RFHNRVA--TYPFDDHN
. .|..  .....|||||| . |.||| .||..      ||.||.....| ..|.....|. . |.||..|.      ||.  .|...|    .|..||.
rsskknlalptelldltyitsriiamgkapsrpllqeideglyrgslkdvaadldnlkedgitlvvnlseeeelsgrsydleeffksgveylhfpieDhg

APPFELIKPFCDDVDEWLKA-SNLNVAIIHCKAGKGRTGVMICAYLLHNGHfKDTKEAMEYYGNARTRNAKGvtIPSQRRYVEYYGYLLR
||... .  .|....|||.. .| ||...|||||.||.|....|||.. |   . .||.|..  .|...|.   .|||.|..||.  ||.
apslselfdicksfiewllsdpngnvVlVHCkaGlgRsGtvvaayLmykgk.ltadeAlelvrekRppgapn..spsqerlleyfaella

subfamily_Tensin_pd Subfamily Tensin 13-184 8.8e-45 145.5 In-house 2-174 (189) alignment
Range on Protein: 13-184
Range on HMM: 2-174/189.0
RRFQEDGFDLDLTYIKPNIVAMGFPSEKLEGVYRNHMDEVYRFLEQKHKDSYKVYNLcSERQYDPMRFHNRVATYPFDDHNAPPFELIKPFCDDVDEWLK
 |. |. .|||||||   |.|. ||.| ||  ||... .| ..|..||.|.| |.|| ||..||  .....|  . . |. ||..| .   | ..|.|||
vryveekvdldltyiteriialsfpaegleekyrenlkdvakllkskhndkylvfnl.sekrydisklnkkvldfGWPdllaPsleklcsicksldsWlk

ASNLNVAIIHCKAGKGRTGVMICAYLLHNGHFKDTKEAMEYYGNARTRNA--KGVTIPSQRRYVEYYGYLLRNC
|   ||...||| ||||.||.. ||. ..   . ...|.. .   |  ..  .|.| |||||||||.  || . 
adpqnvvvvhckGgkgrigvvvsaymkyskisasadaaldrfamkrflddklsgetqPsqrryveyfsglLsgk

0036282 (Phosphotyrosine protein) phosphatases II 19-183 1.4e-43 143.9 In-house 7-171 (174) alignment
Range on Protein: 19-183
Range on HMM: 7-171/174.0
GFDLDLTYIKPNIVAMGFPSEKLEGVYRNHMDEVYRFLEQKHKDSYKVYNLCSERQYDPMRFHNRVATYPFDDHNAPPFELIKPFCDDVDEWLKASNLNV
 ..|||.|| |...|...| . .| .....   | ..|| |....||..|...|...|. |.. ..  .|..||..|... .  |.. |.|.|. .. ..
aspldlsyitprliagqgplafwemlkelgittvvmlleekelglykcinywpelredlerlgiqylylpwpDhgvpdlsillefvkfveealsedpggp

AIIHCKAGKGRTGVMICAYLLHNGHFKDTKEAMEYYGNARTRNAKGVTIPSQRRYVEYYGYLLRN
 ..||.||.||||....|||.. |.. .. .|....  .|. . ..|..|||.|.. |.. ||..
vlVHCsaGvgRtGtlvaaylmlrglleslvdaldlvrelRlqrpgmvqtpsQyrflyyfekllsg

subfamily_Auxilin_pd Subfamily Auxilin 21-182 3.1e-41 133.9 In-house 8-165 (166) alignment
Range on Protein: 21-182
Range on HMM: 8-165/166.0
DLDLTYIKPNIVAMGFPSEKLEGVYRNHMDEVYRFLEQKHKDSYKVYNLcSERQYDPMRFHNRVATYPFDDHNAPPFELIKPFCDDVDEWLKASNLNVAI
|||..||   |. | ||.|..|  |.|..|.|  ||| .|.. |.|||| |.|.|.. ....||  . .  ..||. | .   | ... |||. . || .
dlDisyitsriivmsfPaegvestyknniddvrsfLesrhpekylvynl.sqrtyrtaklssrvveagwparraPnLeslvevcrnlyswlkkdpknvvv

IHCKAGKGRTGVMICAYLLHNGHFKDTKEAMEYYGNArtRNAKGvTIPSQRRYVEYYGYLLR
.||| |.  ..|...|.|..   ......|.. .     | ..|   ||..||.|| . ||.
vhckDGraasavlvsallvfcrllsepesavrlfsvk..rlpig.lspsekryleyladlla

0038934 (Phosphotyrosine protein) phosphatases II 26-171 5.3e-37 122.7 In-house 15-160 (194) alignment
Range on Protein: 26-171
Range on HMM: 15-160/194.0
YIKPNIVAMGFPSEK-----LEGVYRNHMDEVYRFLEQKHKDSYKVYNLC-SERQYDPMRFHN---RVATYPFDDH-NAPPFELIKPFCDDVDEWLKASN
.|.....|...|...     .|..||.... . |.|...... ..|..|. .|| ||| .|..   ..  .|| |. ..|..|... |.| |||.|....
iitgrfiafkvPlsgsldkyieelyrfspedlvrylkllnvklglvidltnteryYdpeefekagieylklpfpddgtvPsleillrfldlvdeflnedp

LNVAIIHCKAGKGRTGVMICAYLLHNGHFkDTKEAMEYYGNARtrnakgvtiPSQR
 .|  .|||||.||||....|||..  .. . .||....  .|         |.. 
ggvvaVHCkaGlgRtGtlvaaYLiyrlgm.saeeAialfrekR.........pgai

0046846 (Phosphotyrosine protein) phosphatases II 14-182 8e-36 118.8 In-house 2-173 (176) alignment
Range on Protein: 14-182
Range on HMM: 2-173/176.0
RFQEDGFDLDLTYIKPNIVAMGFPSEKLEGVYRNHMDEVYRFLEQkhkDSYKVYNLCSER--------Q--YDPMRFHNRVATYPFDDHNAPPFELIKPF
|....|.||||.|| .|......|  . ....|...| . ...|.   . . | ||..|.        .   . .... ..  .|..||..|..||.  .
rlrllgldldldyinanlilgsrpiatqgplprtladflemlkel...gitavvnlteevelgrlkcpnywpeleklgiqylhlpwpDhgvpdlelllel

CDDVDEWLKASnlNVAIIHCKAGKGRTGVMICAYLLHNGHFKDTKEAMEYYGNARTRnaKGVTIPSQRRYVEYYGYLLR
.. ..|.||.   .. ..||.||.||||....||||. ... .  ||.... . | .  . |. |.|.|..... .||.
lefirealkeg..gpvlVHCsaGigRtgtlvaayllelekglsveealalvreqRpl..gavqtpeQyrflyefellll

0039614 (Phosphotyrosine protein) phosphatases II 3-184 1.8e-35 118.2 In-house 50-291 (297) alignment
Range on Protein: 3-184
Range on HMM: 50-291/297.0
YFKQLVSKKKRRFQ--------------EDGFDLDLTYI-----------KPNIVAMGFPSEK-----LEGVYRNHMDEVY-------------------
...  ..|.|.|..              |||.|||..||           .....|...|...     .. |....   .                    
iallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfIatqgPlpetvedFwrmvweqgvtvivmLtklvelgrkcaqywpee

---------RFLEQKHKDSYKVYNLCSERqYDPMRFHNRVATYPFDDHNAPP-FELIKPFCDDVDEWLKAS-NLNVAIIHCKAGKGRTGVMICAYLLH--
         ..|. .|.| |.|..|. .. ... |.....  ... ||..|| .||.  |.. |.|.|... . .. ..||.||.||||..|.|||..  
ggtygdftvtllkvehldgytvrtlevtn.ngesrtvthfqytgwpdhgvppslellleflelvrealaelpkggpvlVHCsaGvgRtGtfiaaylmleq

--NGHFKDTKEAMEYYGNARtrnAKGVTIPSQRRYVEYYGYLLRNC
   ..  | .||.... ..|    ..|..||| |.. .. . |...
lekeggvdvleavkelreqR...pgavqtpsqyrflydallellkr

0043147 (Phosphotyrosine protein) phosphatases II 15-183 1.6e-32 108.0 In-house 6-162 (172) alignment
Range on Protein: 15-183
Range on HMM: 6-162/172.0
FQEDGFDLDLTYIKPNIVAMGFPseklegvYRNHMDEVYRFLEQKHKDSykVYNLCsER---QYDPMRFHNRVATYPFDDHNAPPFELIKPFCDDVDEWL
  .. ..|||.|| ....|. .|       .||......|.| ... .   ..||. |.    .. .|.  ..  .|..||..|..||.  |.. .||.|
dyinasyldlyyipdrfiatqgp.......lrntladfwrmlkelgith..ivnlt.ellydpellerlgiqylylpwpDhgvpllellleflefidell

KASNLNVAIIHCKAGKGRTGVMICAYLLHngHFKDTKEAMEYYGNARtrnAKGVTIPSQRRYVEYYGYLLRN
  |. .. ..||.||.||||....|||..  .  .  ||.... ..|    ..|..|||.|.. |.  ||..
alspggpvlVHCsaGvgRtgtlvaaylml..lglsleeavalvrekR...pgavqnpsqyrflyyfekllll

0041856 (Phosphotyrosine protein) phosphatases II 15-186 1.8e-32 107.8 In-house 7-175 (182) alignment
Range on Protein: 15-186
Range on HMM: 7-175/182.0
FQE---DGFDLDLTYIKPNIVAMGFPSEKLEGVYRNHMDEVYRFLEQKHKDSYK-VYNLCsERQYDPMRFHN---RVATYPFDDHNAPPFELIKPFCDDV
...     ...||.|| .|......|. . .  .......|..||.. ..  .. . ||. |..|.| ....   ..  .|..||..|... .  |...|
ysdilpydhsrdldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt.eelywpellerlgiqylylpwpDhgvpdldelldfieev

DEwlkasNLNVAIIHCKAGKGRTGVMICAYLLHNGHfKDTKEAMEYYGNARtrnAKGVTIPSQRRYVEYYGYLLRNCLT
 |     . .. ..||.||.||||....|||..  .  .  ||.... ..|    ..|..|.| ... .. ..|. .  
le.....eggpvlVHCsaGvgRtgtlvaaylmkklg.vsleeavklvrsrR...pgmvitpnqyfflqlallellllkk

0049260 (Phosphotyrosine protein) phosphatases II 32-182 4.7e-32 106.1 In-house 5-150 (152) alignment
Range on Protein: 32-182
Range on HMM: 5-150/152.0
VAMGFPSEKLEGVYRNHMDEVYRFLEQKHKDSYKVYNLCSERQYDPMRFHNRVATYPFDDHNAPPFELIKPFCDDVDEWLKASNLNVAIIHCKAGKGRTG
.||.|.    .|...|......|.| . . . . ... ..|. .. . .. ..  .|..||..|... . .|. ...|.|. .. .. ..||.||.||||
yampfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyiqylhlpwpDhgvpdlsqlllflllfieklaldkggpvlVHCsaGvgRtg

VMICAYLLHnghfkDTKEAMEYYGNARTRNAKGVTIPSQRRYVEYYGYLLR
....|||..        .. |..   |... ..|. |.|.|.. ..  ||.
tlvaaylml.....lgvsleeavalvrekRpgavpnpgqlrflyefekllk

0037934 (Phosphotyrosine protein) phosphatases II 2-179 5.3e-32 106.7 In-house 3-239 (243) alignment
Range on Protein: 2-179
Range on HMM: 3-239/243.0
SYFKQLVSKKKRRFQ--------------EDGFDLDLTYIKPNIVAMGFPSEK---------LEGVYRNHMDEVY-------------------------
|... .....|.|..              .| ....|.|. |.. |...| ..         .. ..... . .                          
siallpenlsknrysdilpydhsrvklegsdyinanliyvtprliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywpgevtygd

---RFLEQKHKDSYKVYNLCSER--QYDPMRFHNRVATYPFDDHNAPP-FELIKPFCDDVDEWLKA-------SNLNVAIIHCKAGKGRTGVMICAYLLH
   ..|...|.|.|.|..|. |.   .|. |.. ..  .|. ||..|. .| .  |.|.| |....       .. .. ..||.||.||||..|.|||..
ftvtllseehlddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRtGtliaaylml

NG-HfKDTKEAMEYYGNARTRnaKGVTIPSQRRYVEYYGY
   .  |  ||.... . |    |.|..|||.|.. .. .
lllg.vdleeavkllreqRpg..kavqtpsqyrflyeall

0042113 (Phosphotyrosine protein) phosphatases II 2-178 2.7e-31 104.3 In-house 2-239 (245) alignment
Range on Protein: 2-178
Range on HMM: 2-239/245.0
SYFKQLVSKKKRRF-------------QEDGFDLDLTYI----------KPNIVAMGFPSEKLEG-----VYRNHMDEVY--------------------
|... ...|.|.|.             ..||.|||..||          .|.. |...|...  .     .....   .                     
svallpenkdknrysdilpydhtrvklspdggdldsdyinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywplg

----------RFLEQKHKDSYKVYNLCSER-QYDPMRFHNRVATYPFDDHNAPP-FELIKPFCDDVDEWLKASNLNVAIIHCKAGKGRTGVMICAYLLH-
          ..|. .|.|.|.|..|. .. ..|. |.....  .|..||..|.  ||.  |.. |...|.... .. ..||.||.||||..|.|||.. 
esltygdftvtllseehlddytvrtlevtnlgddesrevihyhylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylmle

---NGHFKDTKEAMEYYGNARtrnAKGVTIPSQRRYVEYYG
     .  .  ||.... . |    . |..||| |.. .. 
qlekelgvsleeavkelrsqR...pgavqtpsqyrflyeal

0043336 (Phosphotyrosine protein) phosphatases II 4-177 8.7e-31 102.8 In-house 40-272 (278) alignment
Range on Protein: 4-177
Range on HMM: 40-272/278.0
FKQLVSKKKRRF-------------QEDGFDLDLTYI----------KPNIVAMGFPSEKLEGVYRNHMDE-----------------------------
.. . .|.|.|.             . .|.|||..||          .....|...|... .. ... . |                             
allpenkdknrykdilpydhsrvklsllggdldsdYinAsyvdgynvprkfiatqgPlpetvedFwrmvwelgvttivmLtelvelgrvkcaqYwpggsl

-----VYRFLEQKHKDSYKVYNLCSER-QYDPMRFHNRVATYPFDDHNAP-PFELIKPFCDDVDEWLKaSNLNVAIIHCKAGKGRTGVMICAYLLH----
     . ..|...|.| |.|..|. .. .... |.....  ... ||..| ...|.  |. .|.|.|. .. .. ..||.||.||||..|..|||.    
tygdftvtllkeehlddytvrtlevtnlgdgesrtvthyhylgwpdhgvpeslsllldflkavreale.dsngpvlVHCsaGvgRTGtfialyllleqle

NGHFKDTKEAMEYYGNARtrnAKGVTIPSQRRYVEYY
.... |  ||.... . |   .. |. ||| |.. ..
keggvdleeavkelreqR...pgavqtpsqyrflyea

0040438 (Phosphotyrosine protein) phosphatases II 2-184 9e-29 96.2 In-house 36-278 (317) alignment
Range on Protein: 2-184
Range on HMM: 36-278/317.0
SYFKQLVSKKKRRF-------------QEDGFDLDLTYI----------KPNIVAMGFPSEK-----LEGVYRNHMDEVYRFLEQK--------------
|... ...|.|.|.             . .|.|||..||          |....|...| ..     .. |....   . .. | .              
svaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyvdgpnlkrkfIatqgPlpntvedFwrmvweqgvtvivmLteleelgrekcaqYwplg

----------------HKDSYKVYNLCSERQYDPMRFHNRVATYPF-DDHNAPP-FELIKPFCDDVDEWLKaSNLNVAIIHCKAGKGRTGVMICAYLLH-
                .........|. |  .|.  .....  |.. .||..|| ..|.  |.. |.|.|. .. .. ..||.||.||||..|.|||.. 
etltygdftvtllseeelagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfleavreale.dpggpvlVHCsaGvgRtGtfiaaylmle

---NGHFKDTKEAMEYYGNARtrnAKGVTIPSQRRYVEYYGYLLRNC
    ... | .||.... ..|   ...|. |.| |.. .. . . ..
qlekeggvdveeavkelreqR...pgavqtpeqyrflydalleylkr

0049772 (Phosphotyrosine protein) phosphatases II 21-182 1e-28 96.4 In-house 118-278 (314) alignment
Range on Protein: 21-182
Range on HMM: 118-278/314.0
DLDLTYIKP---------------------NIVAMGFPseklegvyrnhmdevyRFLE-------QkhkdsykvynlcsERQYDPMRFHNRVATY---PF
||.. .| .                     .. ..|..                 ..        .             |..||| .| ... .|   |.
dlnvrdivmsrdevladelsrLdaAlgKtpllildgng................neptaadlellk.............eelydpelferlgikylripv

DDHNAPPFELIKPFCDDVDEWlkaSNLNVAIIHCKAGKGRTGV-MICAYLLHNGHFkDTKEAMEYYGNARTRNAKGVTIPSQRRYVEYYGYLLR
.|..||..| .. |.. ..|.   .. .. ..||||||||||. ...|||..  .. . .||.|.. ..|. | . ..|.....|.... .|| 
pDgsaplledfdeflefieea...dkggpvlvHCkaGkgRtgtfvvaaylmkllgv.sleealedvrlkRpinpnpgfieqleqyefilealle

PTEN_C2 C2 domain of PTEN tumour-suppressor protein 187-336 1.6e-28 90.5 Pfam-A 1-130 (134) alignment
Range on Protein: 187-336
Range on HMM: 1-130/134.0
YVPTMVLLRGFEIITIPNM-QGGNCCPFYIIWQYKVKI-H-TSKLIESSKKGDTSIKLELSQPLPICGDIKVEFFHKD-TFGRKERMFQFWFNTFFISTg
| |. . |... . .|||. ..|.| |.  . . |.|. .  ..  .|... . .. ......||..||..|||.||| .  .||..|..||||.||.. 
ynpkrlelksiilegiPnfktrggckpkvkvyngkkkvfkelasykdsterraktfivkepnrlpveGDvlveflhkdsklpkkekifrvwFNTsFiek.

anmtdsregeptihtfkesrnsDVRWFAIPKQFVDKAHKDNkCKVFSPDFKVSN
                      .     .||. .|||.||   | ||..|||. 
......................nqnvltlpkneLDkalkdk.dkkfsknfkvel

0045450 (Phosphotyrosine protein) phosphatases II 2-177 2e-27 92.2 In-house 48-299 (307) alignment
Range on Protein: 2-177
Range on HMM: 48-299/307.0
SYFKQLVSKKKRRFQE-------------------------------------DGFDLDLTYI----------------------------------KPN
|... ...|.|.|...                                     ||.||....|                                  . .
siallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydlkrkfIatqgPlpetvedFwrmlweqgvtvivmltelvelgre

IVAMGFPSEKLEGVYRNhmdEVYRFLEQKHKDSYKVYNLCSERqYDPMRFHNRVATYPF---DDHNAPP-FELIKPFCDDVDEWLKAS-NLNVAIIHCKA
. |. .|.|. | .|.|    . ..|. .|.|.|.|..|. .. .|.  .. .|  ...    ||..|| || .  |.. |...|... . .. ..||.|
kcaqywPdegeeltygn...ftvtllseehldgytvrtlevtd.ldgtgesrtvthfhytgwpdhgvppsfeelldfieevrkaleelpkggpvlVHCsa

GKGRTGVMICAYLLHNGHF-------KDTKEAMEYYGNARtrnAKGVTIPSQRRYVEYY
|.||||..|.|||.  ..         |  ||.... . |    ..|. |.| |.. ..
GvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqR...pgavqnpeqyrflyea

0040439 (Phosphotyrosine protein) phosphatases II 3-178 3e-27 91.3 In-house 5-242 (249) alignment
Range on Protein: 3-178
Range on HMM: 5-242/249.0
YFKQLVSKKKRRFQ---------------EDGFD--------LDLTYIKPNIVAMGFPSEKLEGVYRNHMDE----------------------------
... ...|.|.|..               ...|.        .|..|||....|...| ..  . ... . |                            
vallpenkdknrypdilpydhsrvklsilpglflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywplgg

-------VYRFLEQKHKDSYKVYNLCSERQYDPMRFHNRVATY-PFDDHNAP-PFELIKPFCDDVDEWLKAS-NLNVAIIHCKAGKGRTGVMICAYLLH-
       . ..|. ..||.|.|..|. .. ||.  .. ..  | .. ||..|  || .  |.. |...|..  . .. ..||.||.||||..|.|||.. 
sleygdftvtllsvevkddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaaylmle

---NGHFKDTKEAMEYYGNARtrnAKGVTIPSQRRYVEYYG
     .  | .||.... ..|    ..|. |.| |.. .. 
qlekelgvdleeavkllrsqR...pgavqnpeqyrflyeal

0048179 (Phosphotyrosine protein) phosphatases II 36-178 4.9e-27 89.8 In-house 3-141 (144) alignment
Range on Protein: 36-178
Range on HMM: 3-141/144.0
FPSEKLEGVYRNHMDEVYRFLEQKHKDSYKVYNLCSERQYDPMRFHN-RVATYPFDDHNAPPF-ELIKPFCDDVDEWLKaSNlNVAIIHCKAGKGRTGVM
.||| |.|.|....  .... . |. . . |.||..|. .. . ... ..  .|..||..|.. ||.  |.. ..|.|. .. .. ..||.||.||||..
npseilpglylgslptaldlellkklgittvinlteeyepefleregiqylhlpwpDhgvpdllellleflefieeale.eg.gpvlVHCsaGvgRtgtl

ICAYLLHNGHfKDTKEAMEYYgnaRTRNAKGVTIPSQRRYVEYYG
..|||..  .  . .||....   |.|.  .|. |.|.|....|.
vaaylmkklg.lsleealalv...rsrrpgavpnpgqlrfLleye

0048076 (Phosphotyrosine protein) phosphatases II 36-181 5.3e-27 89.7 In-house 3-142 (145) alignment
Range on Protein: 36-181
Range on HMM: 3-142/145.0
FPSEKLEGVYRNHMDEVYRFLEQKHKDSYKVYNLCSERQYDPmRFHNRVATYPFDDHNAPPF-ELIKPFCDDVDEWLKASnlNVAIIHCKAGKGRTGVMI
.||| |.|.|.. .  .... . |. . . |.||.||...   |.. ..  .|..||..|.. ||.  |.. ..|.||.   .. ..||.||.||||...
wpseilpglylgslptaldlellkdlgittvlnltselelle.rlgiqylylpwpDhgvpdllellleflefieealkeg..gpvlVHCsaGvgRtgtlv

CAYLLHNGHfKDTKEAMEYYGNARtrnAKGVTIPSQRRYVEYYGYLL
.|||..  .  .  ||.|.. ..|    ..|. |.|.|..... . |
aaylmlllg.vsleealelvrsqr...pgavpnpgqlrflyefelel

0051082 (Phosphotyrosine protein) phosphatases II 22-179 5.9e-27 89.5 In-house 6-149 (151) alignment
Range on Protein: 22-179
Range on HMM: 6-149/151.0
LDLTYIKPNIVAMGFPSEklegvyrnhmdEVYRFLeqKHKDSYKVYNLCS--ERQYDPMRFHN---RVATYPFDDHNAPPFELIKPFCDDVDEWLKASNL
....|. ... ..|.|..           .....|  |. . . ..||.|  ||.|.| ....   .|  .|..|. .|...|. ... .. |.| . . 
infsyvtgglyrsggpla...........dflell..kelgiktivnlrseeergycpeylpelgievlhipildwpdpglplsfdavleflellldkkn

NVAIIHCKAGKGRTGVMICAYLLHNGhfKDTKEAMEYYGNARTrnakGVTIPSQRRYVEYYGY
.. ..||.|||||||.....||.. |   .  ||.|.|   |.    ||..|.| ...... .
gpvlvHCsaGkgRTGtlvalylmllg..vsleealeeyrlkrp....gvvqpnqqflfqlfal

0045098 (Phosphotyrosine protein) phosphatases II 17-184 5.9e-26 86.9 In-house 2-274 (278) alignment
Range on Protein: 17-184
Range on HMM: 2-274/278.0
EDGFDLDLTYIKPNIVAMGFPSEKLEGVYRNHMD------------------------------------------------------------------
|....|||...  .....|.||| ....|....|                                                                  
ealasldlllefefllllgipseitpalylgnldknRykdilpydhsrVkdYINAsyidgypkkfIatqgPlpstvadfwrmlwelgitvivmltelvel

-------------------------EVYRFlEQKHKDSYKVYNLCSERQYDPMRFHNRVATYPFDDHNAPPFE---LIKPFCDDVDEWLK----------
                         ..... .  ..  ..|.||..||.... |. . .  .|..||..|...    .  ... ..|.||          
grekcaqywpeggsltygdftvtllseevl.ddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllssl

--ASNLNVAIIHCKAGKGRTGVMICAYLLHNGHfKDTKEAMEYYGNARTRNAK-GVTIPSQRRYVEYYGYLLRNC
   .. .. ..||.||.||||....|||.     ...  . |..   |..     |....| |..... ..|...
llldsggpvlVHCsaGvgRtGtlvaaylmlell.eggvdlleavkelrsqRpglavqnleqyrflyefllelllr

0044763 (Phosphotyrosine protein) phosphatases II 7-184 2.6e-25 84.5 In-house 6-173 (178) alignment
Range on Protein: 7-184
Range on HMM: 6-173/178.0
LVSKKKRRFQEDGFDLDLTYIKPNIVAMGFPSeklegvyrnhmDEVYRFLEQKHkdSYKVYNLCSE--------RQYDPMRFHNRVATYPFDDHNAPP-F
.|.  ...  | .. .....| |.. ....|.            . ...| . .     . ||..|         .|.|.... ..  .|..||..|. .
rvllsnleglersdyinaseilpglylgslpp...........addlellkelg..ithivnlteelelgflkcdpywpeeagiqylhipipDhgvpdll

ELIKPFCDDVDEWLKASNlNVAIIHCKAGKGRTGVMICAYLLHNGHFkDTKEAMEYYGNARtrnAkGVTIPSQRRYVEYYGYLLRNC
| .  |.. ..|.|. .. .. ..||.||.||.|....|||..  .. .  ||.|.. ..|     .|. |.|.|.....   |.. 
ehflefvefieealdekg.gpvlVHCsaGvgRsgtlvaaylmkklgl.sleeaielvrerR...p.ivpnpgqlrqLyefelrllke

0046845 (Phosphotyrosine protein) phosphatases II 5-177 1e-24 82.8 In-house 24-269 (284) alignment
Range on Protein: 5-177
Range on HMM: 24-269/284.0
KQLVSKKKRRFQE-----------------------------DGFDLDLTYIKPNIVAMGFPSEK-----------------------------LEGVYR
. .  ..| |..                              ||.||||||||....|. .| ..                                 |.
llpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweqnvrvIVmltelvengrekcaqYw

NHMDEVYRF-------LEQKHKDSYKVYNLCSERQ--YDPMRFHNRVATYPFDDHNAPP-FELIKPFCDDVDEWLKA-SNLNVAIIHCKAGKGRTGVMIC
....||...       |. ..||.|.|..|. ..    .. |...     .. ||..|| .| .  |...|.|.|.. .. .. ..||.||.||||..|.
plegevltygdftvtllseevkddytvrtleltnlgytgesrtvthfhytswpdhgvppspedlleflrlvrellenlpgggpivVHCsaGvgRtGtfia

AYLLHNGHFKD-------TKEAMEYYGNARtrnAKGVTIPSQRRYVEYY
..||..   |.         ||. .. . |      |. ..| |.| ..
ldllleqlekeglllgvdvleavkrlreqR...pgmvqtleqyrfvyea

0047943 (Phosphotyrosine protein) phosphatases II 53-176 1.6e-21 72.4 In-house 139-266 (273) alignment
Range on Protein: 53-176
Range on HMM: 139-266/273.0
YRFLEQKHKDSYKVYNLCSER-QYDPMRFHNRVATYPFDDHNAP-PFELIKPFCDDVDEWLKA--SNlNVAIIHCKAGKGRTGVMICAYLL-----HNgH
 ..|....||.|.|..|. .. ...  |. . .  ... ||..|  .| .  |...|...|.|  || .. ..||.||.||||..|...||     .. .
vtllseetkddytvrtleltnlgtgesrtvthfhytgwpdhgvppslesllefielvrkalealpsn.gpvvVHCsaGvgRtgtfialdllldqleke.g

FKDTKEAMEYYGNARtrnAKGVTIPSQRRYVEY
  | .||. .. . |     .|. |.|.|.. .
gvdvleavkllrsqR...pgmvqtpeqyrflye

0051299 (Phosphotyrosine protein) phosphatases II 52-175 3.7e-20 68.0 In-house 150-279 (288) alignment
Range on Protein: 52-175
Range on HMM: 150-279/288.0
VYRFLEQKHKDSYKVYNLCSERQ-----YDPMRFHNRVATYPFDDHNAPP-FELIKPFCDDVDEWLKaSNLNVAIIHCKAGKGRTGVMICAYLLHNGH-F
. ..|. ...|.|.|..|. ..       .  |. .    . . ||..|. .||.  |. .|...|. |. .. ..||.||.||||..|...||..   .
tvtllseevlddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpdspellldflrlvrkala.sgggpvvVHCsaGvgRtgtfialdllleqlek

KDTKEAMEYYGNARTRNAKGVTIPSQRRYVE
. . ...|..   |..    |. |.| |.| 
eggvdvleavkrlreqRpgmvqtpeqyrfvy

0036941 (Phosphotyrosine protein) phosphatases II 36-187 3.4e-18 61.4 In-house 124-282 (297) alignment
Range on Protein: 36-187
Range on HMM: 124-282/297.0
FPSEKLEGVYRNHMDEVYRFLEQKHKDSYKVYNLCSER-QYDPMRFHNRVATYPFDDHNAPP-FELIKPFCDDVDEWLKAS-NLNVAIIHCKAGKGRTGV
.|.|. | .. ...   ..  |....|.|....|. .  .... |. .       .||..|. .. .  |.. |...||.. . .. ..||.||.||.|.
wpleegesltygdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfielvrkvlkllpsggpvlVHCsaGvgRsgt

MICAYLL----HNGHFKDTKEAMEYYGNARTRNAKGVTIPSQRRYVEYYGYLLRNCLTY
.|.|.|.    ....   .    |..   |.. .  |. ..| |.. .. . | .. ..
fiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallellkkklt

0050432 (Phosphotyrosine protein) phosphatases II 54-174 4.1e-15 51.4 In-house 171-291 (308) alignment
Range on Protein: 54-174
Range on HMM: 171-291/308.0
RFLEQKHKDSYKVYNLCSER-QYDPMRFHNRVATYPFDDHNAPP-FELIKPFCDDVDEWLkaSNlNVAIIHCKAGKGRTGVMICAYLL-----HNgHFKD
..|.....|.|.|..|. .  .....|. .        ||..|| .| .  |.. |...|  .. .. ..||.|| ||||..|...||     .. .  |
tllseevlddytvrtleltnlgdgesrtvthfhytnWpdhgvPpspeilldflelvrksl..pg.gpivVHCsaGvGRtGtfialdllleqleke.ggvd

tkeAMEYYGNARTRNAKGVTIPSQRRYV
   . |..   |.. .  |. |.| ...
...vfeavkklReqRpgmvqtpeqylfl

0051429 (Phosphotyrosine protein) phosphatases II 29-178 4.3e-11 38.5 In-house 68-221 (272) alignment
Range on Protein: 29-178
Range on HMM: 68-221/272.0
PNIVAMGFPSEKLEGVYRNHMDEVYRFLEQKHKDSYKVYNLCSERQ--YDPMRFHNRVATYPFDDHNAPPfELIKPFCDDVDEwlkasNLNVaIIHCKAG
|.|  . .| .  .    .... ....|. .... | ...|. ...  .. .| .     . . ||..|. | .. . . . .     . .| ..||.||
pgirylhlpilddsaptilygalrvtllseellldyilrellltlllsagearevmhlhytdwpdhgvpq.eallellellld.....ggpv.lvHCsaG

KGRTGVMICAYLLHNGHFKD------------TKEAMEYYGNARtrnAKGVTIPSQRRYVEYYG
|.|||......||  |  ..              ||.|.   .|   .. |  . |....  . 
kdRTGtvvallllllgvsletivddYlltnlyleeaveelraqr...pgavqteeqylflyeal

PTPc_DSPc_SM00012 89-149 6.1e-11 37.8 In-house 10-72 (105) alignment
Range on Protein: 89-149
Range on HMM: 10-72/105.0
FDDHNAPP-FELIKPFCDDVDEWLKASN-LNVAIIHCKAGKGRTGVMICAYLLHNGHFKDTKE
  ||..|   . |  ....|... ..|.  .  ..||.|| ||||.......|.. . | |||
wpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketke

subfamily_CDC14_pd Subfamily CDC14 21-174 9.5e-11 36.1 In-house 169-316 (328) alignment
Range on Protein: 21-174
Range on HMM: 169-316/328.0
DLDLTYIKPN-IVAMGFPSEK--LEGVYRNHMDEVYRFLEqKHKDSYKVYNLCsERQYDPMRFHNRVAT---YPFDDHNAPPFELIKPFCDDVDEWlkas
  |...| |. ..|.  | .|  ||  |. |  | .     ....  .|  |  .. ||  .| .         | |   |. ...| | . ...     
nGDfnwivPdkflalagPhnkskledgyplhaPeklleyf.rknnvttvvrLn.kklYdakkftdaGfdhkDlffiDGstPsdaivkkfleiaeka....

NLNvAIIHCKAGKGRTGVMICAYLLHNGHFKdTKEAMEYYGNARTrnakGVTIPSQRRYV
. . ...||||| |||| .| .||... .|  ..||. .   .|     |. |  |....
eGa.iavhCkaGLGrtGtLiacylmkhyrft.aaeaiawlricrP....Gsvigpqqkfl

subfamily_PRL_pd Subfamily PRL 52-158 2.6e-10 34.5 In-house 23-130 (151) alignment
Range on Protein: 52-158
Range on HMM: 23-130/151.0
VYRFLEQKHKDSYKVYNLCSERQYDPMRFHN---RVATYPFDDHNAPPFELIKPFCDDVDEWLKASNLNVAIIHCKAGKGRTGVMICAYLLHNGHfkDTK
. .| |. .| . |    . | .||   ...   .|  ..||| ..|| |... . . . |  | .. ..  .|| || ||. |...  |. .|   ...
lekfieelkkeevktvvrvceptydteklekegievldlafddGavPpeevveeWlellkekfkeepkstvavhcvaGlGraPvlvalalieaGm..kye

EAMEYYGNAR
.|.|.  . |
davefirekr

subfamily_DSP11_pd Subfamily DSP11 72-159 2.8e-10 34.4 In-house 67-158 (178) alignment
Range on Protein: 72-159
Range on HMM: 67-158/178.0
ERQYDPMRFHNRVATYP---FDDHNAPPFELIKPFCDDVDEWLK--ASNLNVAIIHCKAGKGRTGVMICAYLLHNGHFKdTKEAMEYYGNART
.| |..  ....  .|       |. |  ||.| |.. |.|.|.  . | ..  .||  |  ||| .|| ||..   .. ...|.| . .|| 
dryykkkeltdegvkylklncpGhevpkeelvkkfkeavkefleknkdndkligvhCthGvnrtGyliCrylidvegye.pedaieafeearG

subfamily_PTPDC1_pd Subfamily PTPDC1 84-172 4.7e-10 34.2 In-house 85-166 (182) alignment
Range on Protein: 84-172
Range on HMM: 85-166/182.0
VATYPFDDHNAPPFELIKPFCDDVDEWLKASnlNVAiIHCKAGKGRTGVMICAYLLHNGHFKdTKEAMEYygnARTRNAKGVTIPSQRR
|  ....|..... | |      |.  |.    .|| .|| ||.|||||.|..||... ... ...|..     | . .| .   .| .
vynfgwkDygvasleriLdivkvvafalqeg..kva.vhChaGlGrtGvliacylvyakrlt.aekaikl...vrskrpksiqtreqve

0048567 (Phosphotyrosine protein) phosphatases II 71-186 5e-10 33.9 In-house 24-143 (157) alignment
Range on Protein: 71-186
Range on HMM: 24-143/157.0
SERQYDPMRFHNR---VATYPFDDHNAPPFELIKPFCDDVDEWLK--ASNLNVAIIHCKAGK---GRTGVMICAYLLHNGHFkdtkEAMEYYGNARTRNA
 .. |... |.     |   .| |.  ..  ..  |.  ....||    . .. ..|||||    |||...|..||.   .|     . | ..  |  . 
pkslynalyFsiddglvyedfffdfGPlnlailyrFilklnkflkilelagkaiavhckaglkkrgrtatLigcYlilhlgf....tpeeaiaplrivrp

KGVTIPSQRRYVEYYGYLLRNCLT
. |  . .  .. .|...| ..| 
gsvpfrdasyllslynltlldvly

subfamily_RNGTT_pd Subfamily RNGTT 93-160 1.4e-09 31.9 In-house 90-156 (189) alignment
Range on Protein: 93-160
Range on HMM: 90-156/189.0
NAPPFELIKPFCDDVDEWLKASNLNVAIIHCKAGKGRTGVMICAYLLHNGHFkDTKEAMEYYGNARTR
.||  | .| |   |.|. | .  .| ..||. |  ||| .|..||... .. . ..|.. . .||  
eaPeaeqvkefiklveeffkknpeevigvhCthGfnRtGFlivsyLvekedw.sveaavalFakaRpp

DSPc Dual specificity phosphatase, catalytic domain 97-160 1.2e-08 29.9 Pfam-A 56-116 (133) alignment
Range on Protein: 97-160
Range on HMM: 56-116/133.0
FELIKPFCDDVDEWlKASNLNVaIIHCKAGKGRTGVMICAYLLHNGHFkDTKEAMEYYGNARTR
 . ..   . ...  .... .| ..||.||  |.. .|.|||.   .. ...||.|.  . | .
skeleeavefieka.eqkgkkv.lVHCqaGisRSatliiaYlmktknl.slneAyefvkerrsk

DSPc Dual specificity phosphatase, catalytic domain 97-160 1.2e-08 29.9 In-house 56-116 (133) alignment
Range on Protein: 97-160
Range on HMM: 56-116/133.0
FELIKPFCDDVDEWlKASNLNVaIIHCKAGKGRTGVMICAYLLHNGHFkDTKEAMEYYGNARTR
 . ..   . ...  .... .| ..||.||  |.. .|.|||.   .. ...||.|.  . | .
skeleeavefieka.eqkgkkv.lVHCqaGisRSatliiaYlmktknl.slneAyefvkerrsk

PTPc_motif_SM00404 88-159 2.2e-07 25.9 In-house 53-122 (140) alignment
Range on Protein: 88-159
Range on HMM: 53-122/140.0
PFDD-HNAPPFELIKPFCDDVDEWlKASNLNVaIIHCKAGKGRTGVMICAYLLHNGHFkDTKEAMEYYGNART
| || .... .. ..   | ...  .... .| ..||.||  |.. .|.|||..  .. ...||.|.. . | 
plddnekdklskyldkvldfiena.ekkggkv.lVHCqaGvSRSatliiaYlmryrql.slaeayefvkerRp

subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 34-136 2.8e-07 24.9 In-house 117-221 (274) alignment
Range on Protein: 34-136
Range on HMM: 117-221/274.0
MGFPSEKLEGVYRNHMDEVYRFLEQKHKDSYKVYNLCSERQYDPMR-FHNRVATYPfdDHNAP-PFELIKPFCDDVDEWLKASNLN--VAIIHCKAGKGR
. || ..   .  .. |   .. . .... |.| .|  . . .. .  |   . .|  ||..|   . .  ....|.|  ...| .   ...|| || ||
vyfPdaedyeiserygdveikvekiverndysvrklvlkylerersvkhywytdWP..dhksPddantlldlvleveesreeenaklapvvvhCsaGiGr

TGVMICA
||. | .
tGcfiai

subfamily_PTPMT1_pd Subfamily PTPMT1 115-158 8.3e-07 23.6 In-house 106-148 (171) alignment
Range on Protein: 115-158
Range on HMM: 106-148/171.0
NLNVAIIHCKAGKGRTGVMICAYLLHNGHFKdTKEAMEYYGNAR
. .   .|||||.||.. .. .||... ... ..||...  . |
kgkrvYvHCkaGrgRsatlvacylmkkekls.peeAlkalkkkR

subfamily_DSP23_pd Subfamily DSP23 89-143 1.6e-06 22.8 In-house 59-111 (148) alignment
Range on Protein: 89-143
Range on HMM: 59-111/148.0
FDDHNAPPFELIKPFCDDVDEwLKASNLNVAiIHCKAGKGRTGVMICAYLLHNGH
 ||.  |  | .. |   |.|  .. |  |. .||  |.|||| |.  ||... .
iddyhppaleqvvefvrvvee.aeekneavs.vhcllgrgrtgtmlacylvkerk

subfamily_DSP19_pd Subfamily DSP19 107-158 2.3e-06 22.0 In-house 82-130 (152) alignment
Range on Protein: 107-158
Range on HMM: 82-130/152.0
VDEWLKASnlNVAIIHCKAGKGRTGVMICAYLLHnGHFKDTKEAMEYYGNAR
..| ...   .. ..||.||  |.  .. |||..  . ....||.|.  .||
ieearskd..gavlvHCnAGvSRsasvviaylmk.keelsleealelvrear

subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 109-149 8.3e-06 19.7 In-house 255-297 (350) alignment
Range on Protein: 109-149
Range on HMM: 255-297/350.0
EWLKASNLNVAIIHCKAGKGRTGVMIC-AYLLHN-GHFKDTKE
..|. ....  ..|| || ||||...   .||..   .. ...
shldnarsspilvhCsaGvGrtGtlvtlDsllsdfeilenltk