Gene PTEN in Nematostella vectensis

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTEN
Subfamily PTEN
Protein sequence
ID Type Fasta BLAST phosphatome Note
NvecP038_AA protein Get Run
NvecP038_AA_1-187 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_PTEN_pd Subfamily PTEN 4-183 8.2e-89 291.4 In-house 2-181 (184) alignment 
Range on Protein: 4-183
Range on HMM: 2-181/184.0
FKQLVSKKKRRFQEDGFDLDLTYIKPNIVAMGFPSEKLEGVYRNHMDEVYRFLEQKHKDSYKVYNLCSERQYDPMRFHNRVATYPFDDHNAPPFELIKPF
....|||||.||.|||.||||.||..||.|||.|.||||..|||....|..|||.||||.||.|||.|||.||  .|..|||.|||||||.||.||....
lrkivskkkkrfkedgldLDlsyiteniiamgyPaeklealyRnsledvvkflekkhkdhykiynlrserkydskkfdgrvavypfdDhnppplelleei

CDDVDEWLKASNLNVAIIHCKAGKGRTGVMICAYLLHNGHFKDTKEAMEYYGNARTRNAKGVTIPSQRRYVEYYGYLLRN
..|...||.... ||...|||||||||||.|.||||.........||.|.. .|||.|.|||||||||||||||  ||..
vediekwleedkknvvvvHCkaGkGRtGvlivayllkslllekaeealelfaeaRtknkkgvtiPsqrRYveYyekllee
subfamily_VSP_pd Subfamily VSP 5-186 3.1e-67 220.6 In-house 17-203 (212) alignment 
Range on Protein: 5-186
Range on HMM: 17-203/212.0
KQLVSKKKRRFQEDGFDLDLTYIKPNIVAMGFPSEKLEGVYRNHMDEVYRFLEQKHKDSYKVYNLCSERQYDPMRFHNRVATYPFDDHNAPPFELIKPFC
..|||. |||...|||||||||.   |.|| |||   . .||| ..|| |||..||.| |||.||||||.||.  |.|||     |||| | .| .  |.
rrlvsenkrrytqdGfdldltyvteriiamsfpssGkqslyrnpisevarfldtkhrdhykvvnlcseraydekyfnnrvkriliddhnvpkleellvft

DDVDEWLKASNLNVAIIHCKAGKGRTGVMICAYLLHNGHFKDTKEAMEYYGNARTRNA-----KGVTIPSQRRYVEYYGYLLRNCLT
 .| |||.. . || .|||| |||||| ..||.||. . |. .||...|.|. || ..     .||  |||.|||.|.  .     .
kevkewlekdlknvlaihckGGkgrtGtivcalllaseifetakesldyfgerrtdktegekfqGvqtpsqkryvgyleqvktkynr
PTEN_1 9-182 2.7e-47 156.1 In-house 7-193 (196) alignment 
Range on Protein: 9-182
Range on HMM: 7-193/196.0
SKKKRRFQEDGFDLDLTYIKPNIVAMG-FPSEK-----LEGVYRNHMDEVYRFLEQKHKDS-YKVYNLCSERQ-----YDPM-RFHNRVA--TYPFDDHN
. .|..  .....|||||| . |.||| .||..      ||.||.....| ..|.....|. . |.||..|.      ||.  .|...|    .|..||.
rsskknlalptelldltyitsriiamgkapsrpllqeideglyrgslkdvaadldnlkedgitlvvnlseeeelsgrsydleeffksgveylhfpieDhg

APPFELIKPFCDDVDEWLKA-SNLNVAIIHCKAGKGRTGVMICAYLLHNGHfKDTKEAMEYYGNARTRNAKGvtIPSQRRYVEYYGYLLR
||... .  .|....|||.. .| ||...|||||.||.|....|||.. |   . .||.|..  .|...|.   .|||.|..||.  ||.
apslselfdicksfiewllsdpngnvVlVHCkaGlgRsGtvvaayLmykgk.ltadeAlelvrekRppgapn..spsqerlleyfaella
subfamily_Tensin_pd Subfamily Tensin 13-184 8.8e-45 145.5 In-house 2-174 (189) alignment 
Range on Protein: 13-184
Range on HMM: 2-174/189.0
RRFQEDGFDLDLTYIKPNIVAMGFPSEKLEGVYRNHMDEVYRFLEQKHKDSYKVYNLcSERQYDPMRFHNRVATYPFDDHNAPPFELIKPFCDDVDEWLK
 |. |. .|||||||   |.|. ||.| ||  ||... .| ..|..||.|.| |.|| ||..||  .....|  . . |. ||..| .   | ..|.|||
vryveekvdldltyiteriialsfpaegleekyrenlkdvakllkskhndkylvfnl.sekrydisklnkkvldfGWPdllaPsleklcsicksldsWlk

ASNLNVAIIHCKAGKGRTGVMICAYLLHNGHFKDTKEAMEYYGNARTRNA--KGVTIPSQRRYVEYYGYLLRNC
|   ||...||| ||||.||.. ||. ..   . ...|.. .   |  ..  .|.| |||||||||.  || . 
adpqnvvvvhckGgkgrigvvvsaymkyskisasadaaldrfamkrflddklsgetqPsqrryveyfsglLsgk
0036282 (Phosphotyrosine protein) phosphatases II 19-183 1.4e-43 143.9 In-house 7-171 (174) alignment 
Range on Protein: 19-183
Range on HMM: 7-171/174.0
GFDLDLTYIKPNIVAMGFPSEKLEGVYRNHMDEVYRFLEQKHKDSYKVYNLCSERQYDPMRFHNRVATYPFDDHNAPPFELIKPFCDDVDEWLKASNLNV
 ..|||.|| |...|...| . .| .....   | ..|| |....||..|...|...|. |.. ..  .|..||..|... .  |.. |.|.|. .. ..
aspldlsyitprliagqgplafwemlkelgittvvmlleekelglykcinywpelredlerlgiqylylpwpDhgvpdlsillefvkfveealsedpggp

AIIHCKAGKGRTGVMICAYLLHNGHFKDTKEAMEYYGNARTRNAKGVTIPSQRRYVEYYGYLLRN
 ..||.||.||||....|||.. |.. .. .|....  .|. . ..|..|||.|.. |.. ||..
vlVHCsaGvgRtGtlvaaylmlrglleslvdaldlvrelRlqrpgmvqtpsQyrflyyfekllsg
subfamily_Auxilin_pd Subfamily Auxilin 21-182 3.1e-41 133.9 In-house 8-165 (166) alignment 
Range on Protein: 21-182
Range on HMM: 8-165/166.0
DLDLTYIKPNIVAMGFPSEKLEGVYRNHMDEVYRFLEQKHKDSYKVYNLcSERQYDPMRFHNRVATYPFDDHNAPPFELIKPFCDDVDEWLKASNLNVAI
|||..||   |. | ||.|..|  |.|..|.|  ||| .|.. |.|||| |.|.|.. ....||  . .  ..||. | .   | ... |||. . || .
dlDisyitsriivmsfPaegvestyknniddvrsfLesrhpekylvynl.sqrtyrtaklssrvveagwparraPnLeslvevcrnlyswlkkdpknvvv

IHCKAGKGRTGVMICAYLLHNGHFKDTKEAMEYYGNArtRNAKGvTIPSQRRYVEYYGYLLR
.||| |.  ..|...|.|..   ......|.. .     | ..|   ||..||.|| . ||.
vhckDGraasavlvsallvfcrllsepesavrlfsvk..rlpig.lspsekryleyladlla
0038934 (Phosphotyrosine protein) phosphatases II 26-171 5.3e-37 122.7 In-house 15-160 (194) alignment 
Range on Protein: 26-171
Range on HMM: 15-160/194.0
YIKPNIVAMGFPSEK-----LEGVYRNHMDEVYRFLEQKHKDSYKVYNLC-SERQYDPMRFHN---RVATYPFDDH-NAPPFELIKPFCDDVDEWLKASN
.|.....|...|...     .|..||.... . |.|...... ..|..|. .|| ||| .|..   ..  .|| |. ..|..|... |.| |||.|....
iitgrfiafkvPlsgsldkyieelyrfspedlvrylkllnvklglvidltnteryYdpeefekagieylklpfpddgtvPsleillrfldlvdeflnedp

LNVAIIHCKAGKGRTGVMICAYLLHNGHFkDTKEAMEYYGNARtrnakgvtiPSQR
 .|  .|||||.||||....|||..  .. . .||....  .|         |.. 
ggvvaVHCkaGlgRtGtlvaaYLiyrlgm.saeeAialfrekR.........pgai
0046846 (Phosphotyrosine protein) phosphatases II 14-182 8e-36 118.8 In-house 2-173 (176) alignment 
Range on Protein: 14-182
Range on HMM: 2-173/176.0
RFQEDGFDLDLTYIKPNIVAMGFPSEKLEGVYRNHMDEVYRFLEQkhkDSYKVYNLCSER--------Q--YDPMRFHNRVATYPFDDHNAPPFELIKPF
|....|.||||.|| .|......|  . ....|...| . ...|.   . . | ||..|.        .   . .... ..  .|..||..|..||.  .
rlrllgldldldyinanlilgsrpiatqgplprtladflemlkel...gitavvnlteevelgrlkcpnywpeleklgiqylhlpwpDhgvpdlelllel

CDDVDEWLKASnlNVAIIHCKAGKGRTGVMICAYLLHNGHFKDTKEAMEYYGNARTRnaKGVTIPSQRRYVEYYGYLLR
.. ..|.||.   .. ..||.||.||||....||||. ... .  ||.... . | .  . |. |.|.|..... .||.
lefirealkeg..gpvlVHCsaGigRtgtlvaayllelekglsveealalvreqRpl..gavqtpeQyrflyefellll
0039614 (Phosphotyrosine protein) phosphatases II 3-184 1.8e-35 118.2 In-house 50-291 (297) alignment 
Range on Protein: 3-184
Range on HMM: 50-291/297.0
YFKQLVSKKKRRFQ--------------EDGFDLDLTYI-----------KPNIVAMGFPSEK-----LEGVYRNHMDEVY-------------------
...  ..|.|.|..              |||.|||..||           .....|...|...     .. |....   .                    
iallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfIatqgPlpetvedFwrmvweqgvtvivmLtklvelgrkcaqywpee

---------RFLEQKHKDSYKVYNLCSERqYDPMRFHNRVATYPFDDHNAPP-FELIKPFCDDVDEWLKAS-NLNVAIIHCKAGKGRTGVMICAYLLH--
         ..|. .|.| |.|..|. .. ... |.....  ... ||..|| .||.  |.. |.|.|... . .. ..||.||.||||..|.|||..  
ggtygdftvtllkvehldgytvrtlevtn.ngesrtvthfqytgwpdhgvppslellleflelvrealaelpkggpvlVHCsaGvgRtGtfiaaylmleq

--NGHFKDTKEAMEYYGNARtrnAKGVTIPSQRRYVEYYGYLLRNC
   ..  | .||.... ..|    ..|..||| |.. .. . |...
lekeggvdvleavkelreqR...pgavqtpsqyrflydallellkr
0043147 (Phosphotyrosine protein) phosphatases II 15-183 1.6e-32 108.0 In-house 6-162 (172) alignment 
Range on Protein: 15-183
Range on HMM: 6-162/172.0
FQEDGFDLDLTYIKPNIVAMGFPseklegvYRNHMDEVYRFLEQKHKDSykVYNLCsER---QYDPMRFHNRVATYPFDDHNAPPFELIKPFCDDVDEWL
  .. ..|||.|| ....|. .|       .||......|.| ... .   ..||. |.    .. .|.  ..  .|..||..|..||.  |.. .||.|
dyinasyldlyyipdrfiatqgp.......lrntladfwrmlkelgith..ivnlt.ellydpellerlgiqylylpwpDhgvpllellleflefidell

KASNLNVAIIHCKAGKGRTGVMICAYLLHngHFKDTKEAMEYYGNARtrnAKGVTIPSQRRYVEYYGYLLRN
  |. .. ..||.||.||||....|||..  .  .  ||.... ..|    ..|..|||.|.. |.  ||..
alspggpvlVHCsaGvgRtgtlvaaylml..lglsleeavalvrekR...pgavqnpsqyrflyyfekllll
0041856 (Phosphotyrosine protein) phosphatases II 15-186 1.8e-32 107.8 In-house 7-175 (182) alignment 
Range on Protein: 15-186
Range on HMM: 7-175/182.0
FQE---DGFDLDLTYIKPNIVAMGFPSEKLEGVYRNHMDEVYRFLEQKHKDSYK-VYNLCsERQYDPMRFHN---RVATYPFDDHNAPPFELIKPFCDDV
...     ...||.|| .|......|. . .  .......|..||.. ..  .. . ||. |..|.| ....   ..  .|..||..|... .  |...|
ysdilpydhsrdldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt.eelywpellerlgiqylylpwpDhgvpdldelldfieev

DEwlkasNLNVAIIHCKAGKGRTGVMICAYLLHNGHfKDTKEAMEYYGNARtrnAKGVTIPSQRRYVEYYGYLLRNCLT
 |     . .. ..||.||.||||....|||..  .  .  ||.... ..|    ..|..|.| ... .. ..|. .  
le.....eggpvlVHCsaGvgRtgtlvaaylmkklg.vsleeavklvrsrR...pgmvitpnqyfflqlallellllkk
0049260 (Phosphotyrosine protein) phosphatases II 32-182 4.7e-32 106.1 In-house 5-150 (152) alignment 
Range on Protein: 32-182
Range on HMM: 5-150/152.0
VAMGFPSEKLEGVYRNHMDEVYRFLEQKHKDSYKVYNLCSERQYDPMRFHNRVATYPFDDHNAPPFELIKPFCDDVDEWLKASNLNVAIIHCKAGKGRTG
.||.|.    .|...|......|.| . . . . ... ..|. .. . .. ..  .|..||..|... . .|. ...|.|. .. .. ..||.||.||||
yampfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyiqylhlpwpDhgvpdlsqlllflllfieklaldkggpvlVHCsaGvgRtg

VMICAYLLHnghfkDTKEAMEYYGNARTRNAKGVTIPSQRRYVEYYGYLLR
....|||..        .. |..   |... ..|. |.|.|.. ..  ||.
tlvaaylml.....lgvsleeavalvrekRpgavpnpgqlrflyefekllk
0037934 (Phosphotyrosine protein) phosphatases II 2-179 5.3e-32 106.7 In-house 3-239 (243) alignment 
Range on Protein: 2-179
Range on HMM: 3-239/243.0
SYFKQLVSKKKRRFQ--------------EDGFDLDLTYIKPNIVAMGFPSEK---------LEGVYRNHMDEVY-------------------------
|... .....|.|..              .| ....|.|. |.. |...| ..         .. ..... . .                          
siallpenlsknrysdilpydhsrvklegsdyinanliyvtprliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywpgevtygd

---RFLEQKHKDSYKVYNLCSER--QYDPMRFHNRVATYPFDDHNAPP-FELIKPFCDDVDEWLKA-------SNLNVAIIHCKAGKGRTGVMICAYLLH
   ..|...|.|.|.|..|. |.   .|. |.. ..  .|. ||..|. .| .  |.|.| |....       .. .. ..||.||.||||..|.|||..
ftvtllseehlddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRtGtliaaylml

NG-HfKDTKEAMEYYGNARTRnaKGVTIPSQRRYVEYYGY
   .  |  ||.... . |    |.|..|||.|.. .. .
lllg.vdleeavkllreqRpg..kavqtpsqyrflyeall
0042113 (Phosphotyrosine protein) phosphatases II 2-178 2.7e-31 104.3 In-house 2-239 (245) alignment 
Range on Protein: 2-178
Range on HMM: 2-239/245.0
SYFKQLVSKKKRRF-------------QEDGFDLDLTYI----------KPNIVAMGFPSEKLEG-----VYRNHMDEVY--------------------
|... ...|.|.|.             ..||.|||..||          .|.. |...|...  .     .....   .                     
svallpenkdknrysdilpydhtrvklspdggdldsdyinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywplg

----------RFLEQKHKDSYKVYNLCSER-QYDPMRFHNRVATYPFDDHNAPP-FELIKPFCDDVDEWLKASNLNVAIIHCKAGKGRTGVMICAYLLH-
          ..|. .|.|.|.|..|. .. ..|. |.....  .|..||..|.  ||.  |.. |...|.... .. ..||.||.||||..|.|||.. 
esltygdftvtllseehlddytvrtlevtnlgddesrevihyhylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylmle

---NGHFKDTKEAMEYYGNARtrnAKGVTIPSQRRYVEYYG
     .  .  ||.... . |    . |..||| |.. .. 
qlekelgvsleeavkelrsqR...pgavqtpsqyrflyeal
0043336 (Phosphotyrosine protein) phosphatases II 4-177 8.7e-31 102.8 In-house 40-272 (278) alignment 
Range on Protein: 4-177
Range on HMM: 40-272/278.0
FKQLVSKKKRRF-------------QEDGFDLDLTYI----------KPNIVAMGFPSEKLEGVYRNHMDE-----------------------------
.. . .|.|.|.             . .|.|||..||          .....|...|... .. ... . |                             
allpenkdknrykdilpydhsrvklsllggdldsdYinAsyvdgynvprkfiatqgPlpetvedFwrmvwelgvttivmLtelvelgrvkcaqYwpggsl

-----VYRFLEQKHKDSYKVYNLCSER-QYDPMRFHNRVATYPFDDHNAP-PFELIKPFCDDVDEWLKaSNLNVAIIHCKAGKGRTGVMICAYLLH----
     . ..|...|.| |.|..|. .. .... |.....  ... ||..| ...|.  |. .|.|.|. .. .. ..||.||.||||..|..|||.    
tygdftvtllkeehlddytvrtlevtnlgdgesrtvthyhylgwpdhgvpeslsllldflkavreale.dsngpvlVHCsaGvgRTGtfialyllleqle

NGHFKDTKEAMEYYGNARtrnAKGVTIPSQRRYVEYY
.... |  ||.... . |   .. |. ||| |.. ..
keggvdleeavkelreqR...pgavqtpsqyrflyea
0040438 (Phosphotyrosine protein) phosphatases II 2-184 9e-29 96.2 In-house 36-278 (317) alignment 
Range on Protein: 2-184
Range on HMM: 36-278/317.0
SYFKQLVSKKKRRF-------------QEDGFDLDLTYI----------KPNIVAMGFPSEK-----LEGVYRNHMDEVYRFLEQK--------------
|... ...|.|.|.             . .|.|||..||          |....|...| ..     .. |....   . .. | .              
svaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyvdgpnlkrkfIatqgPlpntvedFwrmvweqgvtvivmLteleelgrekcaqYwplg

----------------HKDSYKVYNLCSERQYDPMRFHNRVATYPF-DDHNAPP-FELIKPFCDDVDEWLKaSNLNVAIIHCKAGKGRTGVMICAYLLH-
                .........|. |  .|.  .....  |.. .||..|| ..|.  |.. |.|.|. .. .. ..||.||.||||..|.|||.. 
etltygdftvtllseeelagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfleavreale.dpggpvlVHCsaGvgRtGtfiaaylmle

---NGHFKDTKEAMEYYGNARtrnAKGVTIPSQRRYVEYYGYLLRNC
    ... | .||.... ..|   ...|. |.| |.. .. . . ..
qlekeggvdveeavkelreqR...pgavqtpeqyrflydalleylkr
0049772 (Phosphotyrosine protein) phosphatases II 21-182 1e-28 96.4 In-house 118-278 (314) alignment 
Range on Protein: 21-182
Range on HMM: 118-278/314.0
DLDLTYIKP---------------------NIVAMGFPseklegvyrnhmdevyRFLE-------QkhkdsykvynlcsERQYDPMRFHNRVATY---PF
||.. .| .                     .. ..|..                 ..        .             |..||| .| ... .|   |.
dlnvrdivmsrdevladelsrLdaAlgKtpllildgng................neptaadlellk.............eelydpelferlgikylripv

DDHNAPPFELIKPFCDDVDEWlkaSNLNVAIIHCKAGKGRTGV-MICAYLLHNGHFkDTKEAMEYYGNARTRNAKGVTIPSQRRYVEYYGYLLR
.|..||..| .. |.. ..|.   .. .. ..||||||||||. ...|||..  .. . .||.|.. ..|. | . ..|.....|.... .|| 
pDgsaplledfdeflefieea...dkggpvlvHCkaGkgRtgtfvvaaylmkllgv.sleealedvrlkRpinpnpgfieqleqyefilealle
PTEN_C2 C2 domain of PTEN tumour-suppressor protein 187-336 1.6e-28 90.5 Pfam-A 1-130 (134) alignment 
Range on Protein: 187-336
Range on HMM: 1-130/134.0
YVPTMVLLRGFEIITIPNM-QGGNCCPFYIIWQYKVKI-H-TSKLIESSKKGDTSIKLELSQPLPICGDIKVEFFHKD-TFGRKERMFQFWFNTFFISTg
| |. . |... . .|||. ..|.| |.  . . |.|. .  ..  .|... . .. ......||..||..|||.||| .  .||..|..||||.||.. 
ynpkrlelksiilegiPnfktrggckpkvkvyngkkkvfkelasykdsterraktfivkepnrlpveGDvlveflhkdsklpkkekifrvwFNTsFiek.

anmtdsregeptihtfkesrnsDVRWFAIPKQFVDKAHKDNkCKVFSPDFKVSN
                      .     .||. .|||.||   | ||..|||. 
......................nqnvltlpkneLDkalkdk.dkkfsknfkvel
0045450 (Phosphotyrosine protein) phosphatases II 2-177 2e-27 92.2 In-house 48-299 (307) alignment 
Range on Protein: 2-177
Range on HMM: 48-299/307.0
SYFKQLVSKKKRRFQE-------------------------------------DGFDLDLTYI----------------------------------KPN
|... ...|.|.|...                                     ||.||....|                                  . .
siallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydlkrkfIatqgPlpetvedFwrmlweqgvtvivmltelvelgre

IVAMGFPSEKLEGVYRNhmdEVYRFLEQKHKDSYKVYNLCSERqYDPMRFHNRVATYPF---DDHNAPP-FELIKPFCDDVDEWLKAS-NLNVAIIHCKA
. |. .|.|. | .|.|    . ..|. .|.|.|.|..|. .. .|.  .. .|  ...    ||..|| || .  |.. |...|... . .. ..||.|
kcaqywPdegeeltygn...ftvtllseehldgytvrtlevtd.ldgtgesrtvthfhytgwpdhgvppsfeelldfieevrkaleelpkggpvlVHCsa

GKGRTGVMICAYLLHNGHF-------KDTKEAMEYYGNARtrnAKGVTIPSQRRYVEYY
|.||||..|.|||.  ..         |  ||.... . |    ..|. |.| |.. ..
GvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqR...pgavqnpeqyrflyea
0040439 (Phosphotyrosine protein) phosphatases II 3-178 3e-27 91.3 In-house 5-242 (249) alignment 
Range on Protein: 3-178
Range on HMM: 5-242/249.0
YFKQLVSKKKRRFQ---------------EDGFD--------LDLTYIKPNIVAMGFPSEKLEGVYRNHMDE----------------------------
... ...|.|.|..               ...|.        .|..|||....|...| ..  . ... . |                            
vallpenkdknrypdilpydhsrvklsilpglflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywplgg

-------VYRFLEQKHKDSYKVYNLCSERQYDPMRFHNRVATY-PFDDHNAP-PFELIKPFCDDVDEWLKAS-NLNVAIIHCKAGKGRTGVMICAYLLH-
       . ..|. ..||.|.|..|. .. ||.  .. ..  | .. ||..|  || .  |.. |...|..  . .. ..||.||.||||..|.|||.. 
sleygdftvtllsvevkddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaaylmle

---NGHFKDTKEAMEYYGNARtrnAKGVTIPSQRRYVEYYG
     .  | .||.... ..|    ..|. |.| |.. .. 
qlekelgvdleeavkllrsqR...pgavqnpeqyrflyeal
0048179 (Phosphotyrosine protein) phosphatases II 36-178 4.9e-27 89.8 In-house 3-141 (144) alignment 
Range on Protein: 36-178
Range on HMM: 3-141/144.0
FPSEKLEGVYRNHMDEVYRFLEQKHKDSYKVYNLCSERQYDPMRFHN-RVATYPFDDHNAPPF-ELIKPFCDDVDEWLKaSNlNVAIIHCKAGKGRTGVM
.||| |.|.|....  .... . |. . . |.||..|. .. . ... ..  .|..||..|.. ||.  |.. ..|.|. .. .. ..||.||.||||..
npseilpglylgslptaldlellkklgittvinlteeyepefleregiqylhlpwpDhgvpdllellleflefieeale.eg.gpvlVHCsaGvgRtgtl

ICAYLLHNGHfKDTKEAMEYYgnaRTRNAKGVTIPSQRRYVEYYG
..|||..  .  . .||....   |.|.  .|. |.|.|....|.
vaaylmkklg.lsleealalv...rsrrpgavpnpgqlrfLleye
0048076 (Phosphotyrosine protein) phosphatases II 36-181 5.3e-27 89.7 In-house 3-142 (145) alignment 
Range on Protein: 36-181
Range on HMM: 3-142/145.0
FPSEKLEGVYRNHMDEVYRFLEQKHKDSYKVYNLCSERQYDPmRFHNRVATYPFDDHNAPPF-ELIKPFCDDVDEWLKASnlNVAIIHCKAGKGRTGVMI
.||| |.|.|.. .  .... . |. . . |.||.||...   |.. ..  .|..||..|.. ||.  |.. ..|.||.   .. ..||.||.||||...
wpseilpglylgslptaldlellkdlgittvlnltselelle.rlgiqylylpwpDhgvpdllellleflefieealkeg..gpvlVHCsaGvgRtgtlv

CAYLLHNGHfKDTKEAMEYYGNARtrnAKGVTIPSQRRYVEYYGYLL
.|||..  .  .  ||.|.. ..|    ..|. |.|.|..... . |
aaylmlllg.vsleealelvrsqr...pgavpnpgqlrflyefelel
0051082 (Phosphotyrosine protein) phosphatases II 22-179 5.9e-27 89.5 In-house 6-149 (151) alignment 
Range on Protein: 22-179
Range on HMM: 6-149/151.0
LDLTYIKPNIVAMGFPSEklegvyrnhmdEVYRFLeqKHKDSYKVYNLCS--ERQYDPMRFHN---RVATYPFDDHNAPPFELIKPFCDDVDEWLKASNL
....|. ... ..|.|..           .....|  |. . . ..||.|  ||.|.| ....   .|  .|..|. .|...|. ... .. |.| . . 
infsyvtgglyrsggpla...........dflell..kelgiktivnlrseeergycpeylpelgievlhipildwpdpglplsfdavleflellldkkn

NVAIIHCKAGKGRTGVMICAYLLHNGhfKDTKEAMEYYGNARTrnakGVTIPSQRRYVEYYGY
.. ..||.|||||||.....||.. |   .  ||.|.|   |.    ||..|.| ...... .
gpvlvHCsaGkgRTGtlvalylmllg..vsleealeeyrlkrp....gvvqpnqqflfqlfal
0045098 (Phosphotyrosine protein) phosphatases II 17-184 5.9e-26 86.9 In-house 2-274 (278) alignment 
Range on Protein: 17-184
Range on HMM: 2-274/278.0
EDGFDLDLTYIKPNIVAMGFPSEKLEGVYRNHMD------------------------------------------------------------------
|....|||...  .....|.||| ....|....|                                                                  
ealasldlllefefllllgipseitpalylgnldknRykdilpydhsrVkdYINAsyidgypkkfIatqgPlpstvadfwrmlwelgitvivmltelvel

-------------------------EVYRFlEQKHKDSYKVYNLCSERQYDPMRFHNRVATYPFDDHNAPPFE---LIKPFCDDVDEWLK----------
                         ..... .  ..  ..|.||..||.... |. . .  .|..||..|...    .  ... ..|.||          
grekcaqywpeggsltygdftvtllseevl.ddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllssl

--ASNLNVAIIHCKAGKGRTGVMICAYLLHNGHfKDTKEAMEYYGNARTRNAK-GVTIPSQRRYVEYYGYLLRNC
   .. .. ..||.||.||||....|||.     ...  . |..   |..     |....| |..... ..|...
llldsggpvlVHCsaGvgRtGtlvaaylmlell.eggvdlleavkelrsqRpglavqnleqyrflyefllelllr
0044763 (Phosphotyrosine protein) phosphatases II 7-184 2.6e-25 84.5 In-house 6-173 (178) alignment 
Range on Protein: 7-184
Range on HMM: 6-173/178.0
LVSKKKRRFQEDGFDLDLTYIKPNIVAMGFPSeklegvyrnhmDEVYRFLEQKHkdSYKVYNLCSE--------RQYDPMRFHNRVATYPFDDHNAPP-F
.|.  ...  | .. .....| |.. ....|.            . ...| . .     . ||..|         .|.|.... ..  .|..||..|. .
rvllsnleglersdyinaseilpglylgslpp...........addlellkelg..ithivnlteelelgflkcdpywpeeagiqylhipipDhgvpdll

ELIKPFCDDVDEWLKASNlNVAIIHCKAGKGRTGVMICAYLLHNGHFkDTKEAMEYYGNARtrnAkGVTIPSQRRYVEYYGYLLRNC
| .  |.. ..|.|. .. .. ..||.||.||.|....|||..  .. .  ||.|.. ..|     .|. |.|.|.....   |.. 
ehflefvefieealdekg.gpvlVHCsaGvgRsgtlvaaylmkklgl.sleeaielvrerR...p.ivpnpgqlrqLyefelrllke
0046845 (Phosphotyrosine protein) phosphatases II 5-177 1e-24 82.8 In-house 24-269 (284) alignment 
Range on Protein: 5-177
Range on HMM: 24-269/284.0
KQLVSKKKRRFQE-----------------------------DGFDLDLTYIKPNIVAMGFPSEK-----------------------------LEGVYR
. .  ..| |..                              ||.||||||||....|. .| ..                                 |.
llpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweqnvrvIVmltelvengrekcaqYw

NHMDEVYRF-------LEQKHKDSYKVYNLCSERQ--YDPMRFHNRVATYPFDDHNAPP-FELIKPFCDDVDEWLKA-SNLNVAIIHCKAGKGRTGVMIC
....||...       |. ..||.|.|..|. ..    .. |...     .. ||..|| .| .  |...|.|.|.. .. .. ..||.||.||||..|.
plegevltygdftvtllseevkddytvrtleltnlgytgesrtvthfhytswpdhgvppspedlleflrlvrellenlpgggpivVHCsaGvgRtGtfia

AYLLHNGHFKD-------TKEAMEYYGNARtrnAKGVTIPSQRRYVEYY
..||..   |.         ||. .. . |      |. ..| |.| ..
ldllleqlekeglllgvdvleavkrlreqR...pgmvqtleqyrfvyea
0047943 (Phosphotyrosine protein) phosphatases II 53-176 1.6e-21 72.4 In-house 139-266 (273) alignment 
Range on Protein: 53-176
Range on HMM: 139-266/273.0
YRFLEQKHKDSYKVYNLCSER-QYDPMRFHNRVATYPFDDHNAP-PFELIKPFCDDVDEWLKA--SNlNVAIIHCKAGKGRTGVMICAYLL-----HNgH
 ..|....||.|.|..|. .. ...  |. . .  ... ||..|  .| .  |...|...|.|  || .. ..||.||.||||..|...||     .. .
vtllseetkddytvrtleltnlgtgesrtvthfhytgwpdhgvppslesllefielvrkalealpsn.gpvvVHCsaGvgRtgtfialdllldqleke.g

FKDTKEAMEYYGNARtrnAKGVTIPSQRRYVEY
  | .||. .. . |     .|. |.|.|.. .
gvdvleavkllrsqR...pgmvqtpeqyrflye
0051299 (Phosphotyrosine protein) phosphatases II 52-175 3.7e-20 68.0 In-house 150-279 (288) alignment 
Range on Protein: 52-175
Range on HMM: 150-279/288.0
VYRFLEQKHKDSYKVYNLCSERQ-----YDPMRFHNRVATYPFDDHNAPP-FELIKPFCDDVDEWLKaSNLNVAIIHCKAGKGRTGVMICAYLLHNGH-F
. ..|. ...|.|.|..|. ..       .  |. .    . . ||..|. .||.  |. .|...|. |. .. ..||.||.||||..|...||..   .
tvtllseevlddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpdspellldflrlvrkala.sgggpvvVHCsaGvgRtgtfialdllleqlek

KDTKEAMEYYGNARTRNAKGVTIPSQRRYVE
. . ...|..   |..    |. |.| |.| 
eggvdvleavkrlreqRpgmvqtpeqyrfvy
0036941 (Phosphotyrosine protein) phosphatases II 36-187 3.4e-18 61.4 In-house 124-282 (297) alignment 
Range on Protein: 36-187
Range on HMM: 124-282/297.0
FPSEKLEGVYRNHMDEVYRFLEQKHKDSYKVYNLCSER-QYDPMRFHNRVATYPFDDHNAPP-FELIKPFCDDVDEWLKAS-NLNVAIIHCKAGKGRTGV
.|.|. | .. ...   ..  |....|.|....|. .  .... |. .       .||..|. .. .  |.. |...||.. . .. ..||.||.||.|.
wpleegesltygdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfielvrkvlkllpsggpvlVHCsaGvgRsgt

MICAYLL----HNGHFKDTKEAMEYYGNARTRNAKGVTIPSQRRYVEYYGYLLRNCLTY
.|.|.|.    ....   .    |..   |.. .  |. ..| |.. .. . | .. ..
fiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallellkkklt
0050432 (Phosphotyrosine protein) phosphatases II 54-174 4.1e-15 51.4 In-house 171-291 (308) alignment 
Range on Protein: 54-174
Range on HMM: 171-291/308.0
RFLEQKHKDSYKVYNLCSER-QYDPMRFHNRVATYPFDDHNAPP-FELIKPFCDDVDEWLkaSNlNVAIIHCKAGKGRTGVMICAYLL-----HNgHFKD
..|.....|.|.|..|. .  .....|. .        ||..|| .| .  |.. |...|  .. .. ..||.|| ||||..|...||     .. .  |
tllseevlddytvrtleltnlgdgesrtvthfhytnWpdhgvPpspeilldflelvrksl..pg.gpivVHCsaGvGRtGtfialdllleqleke.ggvd

tkeAMEYYGNARTRNAKGVTIPSQRRYV
   . |..   |.. .  |. |.| ...
...vfeavkklReqRpgmvqtpeqylfl
0051429 (Phosphotyrosine protein) phosphatases II 29-178 4.3e-11 38.5 In-house 68-221 (272) alignment 
Range on Protein: 29-178
Range on HMM: 68-221/272.0
PNIVAMGFPSEKLEGVYRNHMDEVYRFLEQKHKDSYKVYNLCSERQ--YDPMRFHNRVATYPFDDHNAPPfELIKPFCDDVDEwlkasNLNVaIIHCKAG
|.|  . .| .  .    .... ....|. .... | ...|. ...  .. .| .     . . ||..|. | .. . . . .     . .| ..||.||
pgirylhlpilddsaptilygalrvtllseellldyilrellltlllsagearevmhlhytdwpdhgvpq.eallellellld.....ggpv.lvHCsaG

KGRTGVMICAYLLHNGHFKD------------TKEAMEYYGNARtrnAKGVTIPSQRRYVEYYG
|.|||......||  |  ..              ||.|.   .|   .. |  . |....  . 
kdRTGtvvallllllgvsletivddYlltnlyleeaveelraqr...pgavqteeqylflyeal
PTPc_DSPc_SM00012 89-149 6.1e-11 37.8 In-house 10-72 (105) alignment 
Range on Protein: 89-149
Range on HMM: 10-72/105.0
FDDHNAPP-FELIKPFCDDVDEWLKASN-LNVAIIHCKAGKGRTGVMICAYLLHNGHFKDTKE
  ||..|   . |  ....|... ..|.  .  ..||.|| ||||.......|.. . | |||
wpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketke
subfamily_CDC14_pd Subfamily CDC14 21-174 9.5e-11 36.1 In-house 169-316 (328) alignment 
Range on Protein: 21-174
Range on HMM: 169-316/328.0
DLDLTYIKPN-IVAMGFPSEK--LEGVYRNHMDEVYRFLEqKHKDSYKVYNLCsERQYDPMRFHNRVAT---YPFDDHNAPPFELIKPFCDDVDEWlkas
  |...| |. ..|.  | .|  ||  |. |  | .     ....  .|  |  .. ||  .| .         | |   |. ...| | . ...     
nGDfnwivPdkflalagPhnkskledgyplhaPeklleyf.rknnvttvvrLn.kklYdakkftdaGfdhkDlffiDGstPsdaivkkfleiaeka....

NLNvAIIHCKAGKGRTGVMICAYLLHNGHFKdTKEAMEYYGNARTrnakGVTIPSQRRYV
. . ...||||| |||| .| .||... .|  ..||. .   .|     |. |  |....
eGa.iavhCkaGLGrtGtLiacylmkhyrft.aaeaiawlricrP....Gsvigpqqkfl
subfamily_PRL_pd Subfamily PRL 52-158 2.6e-10 34.5 In-house 23-130 (151) alignment 
Range on Protein: 52-158
Range on HMM: 23-130/151.0
VYRFLEQKHKDSYKVYNLCSERQYDPMRFHN---RVATYPFDDHNAPPFELIKPFCDDVDEWLKASNLNVAIIHCKAGKGRTGVMICAYLLHNGHfkDTK
. .| |. .| . |    . | .||   ...   .|  ..||| ..|| |... . . . |  | .. ..  .|| || ||. |...  |. .|   ...
lekfieelkkeevktvvrvceptydteklekegievldlafddGavPpeevveeWlellkekfkeepkstvavhcvaGlGraPvlvalalieaGm..kye

EAMEYYGNAR
.|.|.  . |
davefirekr
subfamily_DSP11_pd Subfamily DSP11 72-159 2.8e-10 34.4 In-house 67-158 (178) alignment 
Range on Protein: 72-159
Range on HMM: 67-158/178.0
ERQYDPMRFHNRVATYP---FDDHNAPPFELIKPFCDDVDEWLK--ASNLNVAIIHCKAGKGRTGVMICAYLLHNGHFKdTKEAMEYYGNART
.| |..  ....  .|       |. |  ||.| |.. |.|.|.  . | ..  .||  |  ||| .|| ||..   .. ...|.| . .|| 
dryykkkeltdegvkylklncpGhevpkeelvkkfkeavkefleknkdndkligvhCthGvnrtGyliCrylidvegye.pedaieafeearG
subfamily_PTPDC1_pd Subfamily PTPDC1 84-172 4.7e-10 34.2 In-house 85-166 (182) alignment 
Range on Protein: 84-172
Range on HMM: 85-166/182.0
VATYPFDDHNAPPFELIKPFCDDVDEWLKASnlNVAiIHCKAGKGRTGVMICAYLLHNGHFKdTKEAMEYygnARTRNAKGVTIPSQRR
|  ....|..... | |      |.  |.    .|| .|| ||.|||||.|..||... ... ...|..     | . .| .   .| .
vynfgwkDygvasleriLdivkvvafalqeg..kva.vhChaGlGrtGvliacylvyakrlt.aekaikl...vrskrpksiqtreqve
0048567 (Phosphotyrosine protein) phosphatases II 71-186 5e-10 33.9 In-house 24-143 (157) alignment 
Range on Protein: 71-186
Range on HMM: 24-143/157.0
SERQYDPMRFHNR---VATYPFDDHNAPPFELIKPFCDDVDEWLK--ASNLNVAIIHCKAGK---GRTGVMICAYLLHNGHFkdtkEAMEYYGNARTRNA
 .. |... |.     |   .| |.  ..  ..  |.  ....||    . .. ..|||||    |||...|..||.   .|     . | ..  |  . 
pkslynalyFsiddglvyedfffdfGPlnlailyrFilklnkflkilelagkaiavhckaglkkrgrtatLigcYlilhlgf....tpeeaiaplrivrp

KGVTIPSQRRYVEYYGYLLRNCLT
. |  . .  .. .|...| ..| 
gsvpfrdasyllslynltlldvly
subfamily_RNGTT_pd Subfamily RNGTT 93-160 1.4e-09 31.9 In-house 90-156 (189) alignment 
Range on Protein: 93-160
Range on HMM: 90-156/189.0
NAPPFELIKPFCDDVDEWLKASNLNVAIIHCKAGKGRTGVMICAYLLHNGHFkDTKEAMEYYGNARTR
.||  | .| |   |.|. | .  .| ..||. |  ||| .|..||... .. . ..|.. . .||  
eaPeaeqvkefiklveeffkknpeevigvhCthGfnRtGFlivsyLvekedw.sveaavalFakaRpp
DSPc Dual specificity phosphatase, catalytic domain 97-160 1.2e-08 29.9 Pfam-A 56-116 (133) alignment 
Range on Protein: 97-160
Range on HMM: 56-116/133.0
FELIKPFCDDVDEWlKASNLNVaIIHCKAGKGRTGVMICAYLLHNGHFkDTKEAMEYYGNARTR
 . ..   . ...  .... .| ..||.||  |.. .|.|||.   .. ...||.|.  . | .
skeleeavefieka.eqkgkkv.lVHCqaGisRSatliiaYlmktknl.slneAyefvkerrsk
DSPc Dual specificity phosphatase, catalytic domain 97-160 1.2e-08 29.9 In-house 56-116 (133) alignment 
Range on Protein: 97-160
Range on HMM: 56-116/133.0
FELIKPFCDDVDEWlKASNLNVaIIHCKAGKGRTGVMICAYLLHNGHFkDTKEAMEYYGNARTR
 . ..   . ...  .... .| ..||.||  |.. .|.|||.   .. ...||.|.  . | .
skeleeavefieka.eqkgkkv.lVHCqaGisRSatliiaYlmktknl.slneAyefvkerrsk
PTPc_motif_SM00404 88-159 2.2e-07 25.9 In-house 53-122 (140) alignment 
Range on Protein: 88-159
Range on HMM: 53-122/140.0
PFDD-HNAPPFELIKPFCDDVDEWlKASNLNVaIIHCKAGKGRTGVMICAYLLHNGHFkDTKEAMEYYGNART
| || .... .. ..   | ...  .... .| ..||.||  |.. .|.|||..  .. ...||.|.. . | 
plddnekdklskyldkvldfiena.ekkggkv.lVHCqaGvSRSatliiaYlmryrql.slaeayefvkerRp
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 34-136 2.8e-07 24.9 In-house 117-221 (274) alignment 
Range on Protein: 34-136
Range on HMM: 117-221/274.0
MGFPSEKLEGVYRNHMDEVYRFLEQKHKDSYKVYNLCSERQYDPMR-FHNRVATYPfdDHNAP-PFELIKPFCDDVDEWLKASNLN--VAIIHCKAGKGR
. || ..   .  .. |   .. . .... |.| .|  . . .. .  |   . .|  ||..|   . .  ....|.|  ...| .   ...|| || ||
vyfPdaedyeiserygdveikvekiverndysvrklvlkylerersvkhywytdWP..dhksPddantlldlvleveesreeenaklapvvvhCsaGiGr

TGVMICA
||. | .
tGcfiai
subfamily_PTPMT1_pd Subfamily PTPMT1 115-158 8.3e-07 23.6 In-house 106-148 (171) alignment 
Range on Protein: 115-158
Range on HMM: 106-148/171.0
NLNVAIIHCKAGKGRTGVMICAYLLHNGHFKdTKEAMEYYGNAR
. .   .|||||.||.. .. .||... ... ..||...  . |
kgkrvYvHCkaGrgRsatlvacylmkkekls.peeAlkalkkkR
subfamily_DSP23_pd Subfamily DSP23 89-143 1.6e-06 22.8 In-house 59-111 (148) alignment 
Range on Protein: 89-143
Range on HMM: 59-111/148.0
FDDHNAPPFELIKPFCDDVDEwLKASNLNVAiIHCKAGKGRTGVMICAYLLHNGH
 ||.  |  | .. |   |.|  .. |  |. .||  |.|||| |.  ||... .
iddyhppaleqvvefvrvvee.aeekneavs.vhcllgrgrtgtmlacylvkerk
subfamily_DSP19_pd Subfamily DSP19 107-158 2.3e-06 22.0 In-house 82-130 (152) alignment 
Range on Protein: 107-158
Range on HMM: 82-130/152.0
VDEWLKASnlNVAIIHCKAGKGRTGVMICAYLLHnGHFKDTKEAMEYYGNAR
..| ...   .. ..||.||  |.  .. |||..  . ....||.|.  .||
ieearskd..gavlvHCnAGvSRsasvviaylmk.keelsleealelvrear
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 109-149 8.3e-06 19.7 In-house 255-297 (350) alignment 
Range on Protein: 109-149
Range on HMM: 255-297/350.0
EWLKASNLNVAIIHCKAGKGRTGVMIC-AYLLHN-GHFKDTKE
..|. ....  ..|| || ||||...   .||..   .. ...
shldnarsspilvhCsaGvGrtGtlvtlDsllsdfeilenltk