Gene VSP in Nematostella vectensis

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTEN
Subfamily VSP
Protein sequence
ID Type Fasta BLAST phosphatome Note
NvecP040_AA protein Get Run
NvecP040_AA_192-412 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_VSP_pd Subfamily VSP 195-405 3.4e-123 403.4 In-house 2-212 (212) alignment 
Range on Protein: 195-405
Range on HMM: 2-212/212.0
FIRIVTGKDQLERATRRMISQNKRRYQQDGFDLDLTYVTERVIAMSFPSSGKHKMYRNPISEVARFLDTKHSDHYKVYNLCSERSYDPSIFHNQVERILI
..|..|.|..||.|.||..|.|||||.||||||||||||||.||||||||||...||||||||||||||||.|||||.||||||.||...|.|.|.||||
ilrlltqkrklekaarrlvsenkrrytqdGfdldltyvteriiamsfpssGkqslyrnpisevarfldtkhrdhykvvnlcseraydekyfnnrvkrili

DDHNVPRLSQLLYFCHNVREWLDKDPSNVIAVHCKGGKGRTGTAICAWLIASGQFEQAQHSLEYFGVRRTDYSVGKTYQGVQTPSQGRYVGYLEQIFTKL
||||||.|..||.|...|.|||.||..||.|.|||||||||||..||.|.||..||.|..||.|||.||||...|...|||||||| ||||||||..||.
ddhnvpkleellvftkevkewlekdlknvlaihckGGkgrtGtivcalllaseifetakesldyfgerrtdktegekfqGvqtpsqkryvgyleqvktky

NRRMPPAVTLK
||..|||.|||
nrklppaktlk
subfamily_PTEN_pd Subfamily PTEN 210-393 4.1e-70 230.5 In-house 3-181 (184) alignment 
Range on Protein: 210-393
Range on HMM: 3-181/184.0
RRMISQNKRRYQQDGFDLDLTYVTERVIAMSFPSSGKHKMYRNPISEVARFLDTKHSDHYKVYNLCSERSYDPSIFHNQVERILIDDHNVPRLSQLLYFC
|...|..|.|...||.||||.|.||..|||..|. . ...||| ...| .||..||.||||.|||.|||.|| . |...|  . .|||| |.|. |  ..
rkivskkkkrfkedgldLDlsyiteniiamgyPaeklealyRnsledvvkflekkhkdhykiynlrserkydskkfdgrvavypfdDhnppplelleeiv

HNVREWLDKDPSNVIAVHCKGGKGRTGTAICAWLIASGQFEQAQHSLEYFGVRRTDYSvgktyQGVQTPSQGRYVGYLEQIFTK
.....||..|..||..|||| ||||||. |.|.|. |...|.|...||.|   || ..     .||. ||| ||| | |.. ..
ediekwleedkknvvvvHCkaGkGRtGvlivayllkslllekaeealelfaeaRtknk.....kgvtiPsqrRYveYyekllee
subfamily_Tensin_pd Subfamily Tensin 218-392 1e-46 151.9 In-house 2-172 (189) alignment 
Range on Protein: 218-392
Range on HMM: 2-172/189.0
RRYQQDGFDLDLTYVTERVIAMSFPSSGKHKMYRNPISEVARFLDTKHSDHYKVYNLcSERSYDPSIFHNQVERILIDDHNVPRLSQLLYFCHNVREWLD
 || .. .||||||.|||.||.|||..|... ||. . .||..|..||.|.| |.|| ||..|| | ....|  .   |.  | | .|   |... .||.
vryveekvdldltyiteriialsfpaegleekyrenlkdvakllkskhndkylvfnl.sekrydisklnkkvldfGWPdllaPsleklcsicksldsWlk

KDPSNVIAVHCKGGKGRTGTAICAWLIASGQFEQAQHSLEYFGVRRTdysVGKTYQGVQTPSQGRYVGYLEQIFT
.|| ||..|||||||||.|  . |..  |   . |. .|. | ..|    . .  .|.. ||| ||| |......
adpqnvvvvhckGgkgrigvvvsaymkyskisasadaaldrfamkrf...lddklsgetqPsqrryveyfsglLs
PTEN_1 214-391 2e-45 150.0 In-house 7-192 (196) alignment 
Range on Protein: 214-391
Range on HMM: 7-192/196.0
SQNKRRYQQDGFDLDLTYVTERVIAMS-FPSSG-----KHKMYRNPISEVARFLDTKHSDH-YKVYNLCSER-----SYDPSI-FHNQVE--RILIDDHN
. .|... .....|||||.|.|.|||. .|| .      ...||.....||..||....|. . |.||..|.     |||... |...||  .. |.||.
rsskknlalptelldltyitsriiamgkapsrpllqeideglyrgslkdvaadldnlkedgitlvvnlseeeelsgrsydleeffksgveylhfpieDhg

VPRLSQLLYFCHNVREWLDKDP-SNVIAVHCKGGKGRTGTAICAWLIASGQfEQAQHSLEYFGVRRTDYSVGktyqgvqTPSQGRYVGYLEQIF
.| ||.|. .| .. ||| .||  ||..||||.|.||.|| ..|.|...|.   |.  ||..  .|.  ..        .||| |.. | ....
apslselfdicksfiewllsdpngnvVlVHCkaGlgRsGtvvaayLmykgk.ltadeAlelvrekRppgapn.......spsqerlleyfaell
subfamily_Auxilin_pd Subfamily Auxilin 226-391 1.2e-42 138.4 In-house 8-164 (166) alignment 
Range on Protein: 226-391
Range on HMM: 8-164/166.0
DLDLTYVTERVIAMSFPSSGKHKMYRNPISEVARFLDTKHSDHYKVYNLcSERSYDPSIFHNQVERILIDDHNVPRLSQLLYFCHNVREWLDKDPSNVIA
|||..|.| |.| ||||. | .  |.| | .|. ||...|...|.|||| |.|.|... ....|  . .  ...| |..|.  | |.  || |||.||. 
dlDisyitsriivmsfPaegvestyknniddvrsfLesrhpekylvynl.sqrtyrtaklssrvveagwparraPnLeslvevcrnlyswlkkdpknvvv

VHCKGGKGRTGTAICAWLIASGQFEQAQHSLEYFGVRRTDYSvgktyqgvQTPSQGRYVGYLEQIF
|||| |.  ... ..|.|.    ......... | |.|.  .         .||. ||. || ...
vhckDGraasavlvsallvfcrllsepesavrlfsvkrlpig........lspsekryleyladll
0036282 (Phosphotyrosine protein) phosphatases II 224-390 3.9e-40 132.7 In-house 7-168 (174) alignment 
Range on Protein: 224-390
Range on HMM: 7-168/174.0
GFDLDLTYVTERVIAMSFPSSGKHKMYRNPISEVARFLDTKHSDHYKVYNLCSERSYDPSIFHNQVERILIDDHNVPRLSQLLYFCHNVREWLDKDPSNV
 ..|||.|.|.|.||...| .  . .... |. | ..|. |. ..||..|...|...|.. .. |. .. ..||.|| ||.|| |.  |.|.| .||...
aspldlsyitprliagqgplafwemlkelgittvvmlleekelglykcinywpelredlerlgiqylylpwpDhgvpdlsillefvkfveealsedpggp

IAVHCKGGKGRTGTAICAWLIASGQFEQAQHSLEYFGVRRTdysvgKTYQGVQTPSQGRYVGYLEQI
..|||..|.||||| ..|.|.  |..| ... |...  .|.     .  ..|||||| |.. |.|..
vlVHCsaGvgRtGtlvaaylmlrglleslvdaldlvrelRl.....qrpgmvqtpsQyrflyyfekl
0038934 (Phosphotyrosine protein) phosphatases II 231-383 4.8e-37 122.9 In-house 15-162 (194) alignment 
Range on Protein: 231-383
Range on HMM: 15-162/194.0
YVTERVIAMSFPSSG-----KHKMYRNPISEVARFLDTKHSDHYKVYNLC-SERSYDPSIFHN---QVERILIDD-HNVPRLSQLLYFCHNVREWLDKDP
..|.|.||...|.||      . .||.... . |.|.... ....|..|. .|| |||. |..   .. .. . | ..|| |..|| |.. | |.|..||
iitgrfiafkvPlsgsldkyieelyrfspedlvrylkllnvklglvidltnteryYdpeefekagieylklpfpddgtvPsleillrfldlvdeflnedp

SNVIAVHCKGGKGRTGTAICAWLIASGQFeQAQHSLEYFGVRRtdysvgktyqgvqtPSQGRY
..|.|||||.|.||||| ..|.|| . ..  |. ....|  .|              |.. ..
ggvvaVHCkaGlgRtGtlvaaYLiyrlgm.saeeAialfrekR..............pgaipn
0039614 (Phosphotyrosine protein) phosphatases II 197-396 2.2e-33 111.4 In-house 40-293 (297) alignment 
Range on Protein: 197-396
Range on HMM: 40-293/297.0
RIVTGKDQlERATRRMISQNKRRYQ--------------QDGFDLDLTYV-----------TERVIAMSFPSSGK-----HKMYRNPISEVA--------
...  |.   . ...  ...|.||.               ||.|||..|.           | ..||...|...      . .... .. .         
ellslkpd.ysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfIatqgPlpetvedFwrmvweqgvtvivmLtklvel

--------------------RFLDTKHSDHYKVYNLCSERsYDPSIFHNQVERILIDDHNVP-RLSQLLYFCHNVREWLDKD-PSNVIAVHCKGGKGRTG
                    ..|...| |.|.|..|. .. ...| .....  . . ||.||  |..|| |.. |||.| .. ......|||..|.||||
grkcaqywpeeggtygdftvtllkvehldgytvrtlevtn.ngesrtvthfqytgwpdhgvppslellleflelvrealaelpkggpvlVHCsaGvgRtG

TAICAWLIA----SGQFEQAQHSLEYFGVRRtdysvgktYQGVQTPSQGRYVGYLEQIFTKLNR
| |.|.|.     ...   ... ....  .|        ...|||||| |.. .... . | ..
tfiaaylmleqlekeggvdvleavkelreqR........pgavqtpsqyrflydallellkrkl
0041856 (Phosphotyrosine protein) phosphatases II 215-395 3.9e-32 106.7 In-house 2-174 (182) alignment 
Range on Protein: 215-395
Range on HMM: 2-174/182.0
QNKRRYQQ---DGFDLDLTYVTERVIAMSFPSSGKHKMYRNPISEVARFLDTKHSDHYK-VYNLCsERSYDPSIFHN---QVERILIDDHNVPRLSQLLY
..|.||.      ...||.|........|.|..  . ......|.||.||.. .. ... . ||. |. |.|. ...   |. .. ..||.|| |..|| 
ldknrysdilpydhsrdldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt.eelywpellerlgiqylylpwpDhgvpdldelld

FCHNVREwldkdPSNVIAVHCKGGKGRTGTAICAWLIASGQfEQAQHSLEYFGVRRtdysvgktYQGVQTPSQGRYVGYLEQIFTKLN
|.. |.|     ......|||..|.||||| ..|.|. . .   ... ....  ||         ..|.||.|.... ...  . .|.
fieevle.....eggpvlVHCsaGvgRtgtlvaaylmkklg.vsleeavklvrsrR........pgmvitpnqyfflqlallellllk
0037934 (Phosphotyrosine protein) phosphatases II 211-390 5.2e-31 103.5 In-house 7-240 (243) alignment 
Range on Protein: 211-390
Range on HMM: 7-240/243.0
RMISQNKRRYQ--------------QDGFDLDLTYVTERVIAMSFPSSG---------KHKMYRNPISEVA----------------------------R
.. ...|.||.               | ....|.|||.|.||...| ..          . .... |. .                             .
lpenlsknrysdilpydhsrvklegsdyinanliyvtprliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywpgevtygdftvt

FLDTKHSDHYKVYNLCSER--SYDPSIFHNQVERILIDDHNVPR-LSQLLYFCHNVREWLDK-------DPSNVIAVHCKGGKGRTGTAICAWLIASG-Q
.|...| |.|.|..|. |.   .|.. .. .. .. . ||.||   ..|| |.. |||....       |......|||..|.||||| |.|.|. .  .
llseehlddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRtGtliaaylmllllg

fEQAQHSLEYFGVRRTDysvgktyQGVQTPSQGRYVGYLEQI
   ... ....  .|          .|||||| |.. .... 
.vdleeavkllreqRpg.......kavqtpsqyrflyealle
0043336 (Phosphotyrosine protein) phosphatases II 195-389 8.9e-31 102.8 In-house 26-274 (278) alignment 
Range on Protein: 195-389
Range on HMM: 26-274/278.0
FIRIVTGKDQLERATRRMISQNKRRY-------------QQDGFDLDLTYV----------TERVIAMSFPSSGKHKMYRNPISE---------------
| .. . |    . .... ...|.||             . .|.|||..|.          ....||...|...  . ... . |               
feellsfkldtysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyvdgynvprkfiatqgPlpetvedFwrmvwelgvttivmLtelvel

-------------------VARFLDTKHSDHYKVYNLCSER-SYDPSIFHNQVERILIDDHNVP-RLSQLLYFCHNVREWLDkDPSNVIAVHCKGGKGRT
                   . ..|...| |.|.|..|. ..  ...| .....  . . ||.||  ||.|| |.. |||.|. |......|||..|.|||
grvkcaqYwpggsltygdftvtllkeehlddytvrtlevtnlgdgesrtvthyhylgwpdhgvpeslsllldflkavreale.dsngpvlVHCsaGvgRT

GTAICAWLIA----SGQFEQAQHSLEYFGVRRtdysvgktYQGVQTPSQGRYVGYLEQ
|| |...|.     ....  ... ....  .|        .. |||||| |.. ....
GtfialyllleqlekeggvdleeavkelreqR........pgavqtpsqyrflyeall
0046846 (Phosphotyrosine protein) phosphatases II 219-391 8.1e-30 99.3 In-house 2-172 (176) alignment 
Range on Protein: 219-391
Range on HMM: 2-172/176.0
RYQQDGFDLDLTYVTERVIAMSFPSSGKHKMYRNPISEVARFLDTkhsDHYKVYNLCSER-------SYDPSIFH---NQVERILIDDHNVPRLSQLLYF
|....|.||||.|.....|..|.|  . . ..|.  . ......    ... | ||..|.        .......    |. .. ..||.|| |..|| .
rlrllgldldldyinanlilgsrpiatqgplprtladflemlkel...gitavvnlteevelgrlkcpnywpeleklgiqylhlpwpDhgvpdlelllel

CHNVREWLDKDpsNVIAVHCKGGKGRTGTAICAWLIASGQFEQAQHSLEYFGVRRTDysvgktyQGVQTPSQGRYVGYLEQIF
.  .||.|...  ....|||..|.||||| ..|.|. ....  ... |...  .|         . ||||.| |.. . |. .
lefirealkeg..gpvlVHCsaGigRtgtlvaayllelekglsveealalvreqRpl.......gavqtpeQyrflyefelll
0043147 (Phosphotyrosine protein) phosphatases II 218-392 1.1e-29 98.7 In-house 4-161 (172) alignment 
Range on Protein: 218-392
Range on HMM: 4-161/172.0
RRYQQDGFDLDLTYVTERVIAMSFPssgkhkmYRNPISEVARFLDTKHSDHykVYNLCsER---SYDPSIFHNQVERILIDDHNVPRLSQLLYFCHNVRE
...  . ..|||.|.. |.||. .|       .||..... |.| ... .|  ..||. |.    .. . .  |. .. ..||.|| |..|| |.. ..|
gsdyinasyldlyyipdrfiatqgp.......lrntladfwrmlkelgith..ivnlt.ellydpellerlgiqylylpwpDhgvpllellleflefide

WLDKDPSNVIAVHCKGGKGRTGTAICAWLIAsgQFEQAQHSLEYFGVRRtdysvgktYQGVQTPSQGRYVGYLEQIFT
.| ..|.....|||..|.||||| ..|.|.   .   ... ....  .|         ..||.||| |.. |.|..  
llalspggpvlVHCsaGvgRtgtlvaaylml..lglsleeavalvrekR........pgavqnpsqyrflyyfeklll
0042113 (Phosphotyrosine protein) phosphatases II 209-390 7.5e-29 96.3 In-house 4-241 (245) alignment 
Range on Protein: 209-390
Range on HMM: 4-241/245.0
TRRMISQNKRRY-------------QQDGFDLDLTYV----------TERVIAMSFPSSGKHK-----MYRNPISEVA----------------------
.... ...|.||             . ||.|||..|.          |...||...|...  .     .... |. .                       
allpenkdknrysdilpydhtrvklspdggdldsdyinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywplges

--------RFLDTKHSDHYKVYNLCSER-SYDPSIFHNQVERILIDDHNVPR-LSQLLYFCHNVREWLDKDPSNVIAVHCKGGKGRTGTAICAWLIA---
        ..|...| |.|.|..|. ..  .|.| ..... .. ..||.||  |..|| |.. ||..| .|......|||..|.||||| |.|.|..   
ltygdftvtllseehlddytvrtlevtnlgddesrevihyhylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylmleql

-SGQFEQAQHSLEYFGVRRtdysvgktYQGVQTPSQGRYVGYLEQI
 . .   ... ....  .|        .. |||||| |.. .... 
ekelgvsleeavkelrsqR........pgavqtpsqyrflyealle
0040438 (Phosphotyrosine protein) phosphatases II 193-412 7.7e-29 96.4 In-house 22-296 (317) alignment 
Range on Protein: 193-412
Range on HMM: 22-296/317.0
LFFIRIVTGKDQLERATRRMISQNKRRY-------------QQDGFDLDLTYV----------TERVIAMSFPSSG-----KHKMYRNPISEVARFLDTK
 .|... . |    . ...  ...|.||             . .|.|||..|.          . . ||...| ..      . .... .. . .. ...
eefedllslkldtysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyvdgpnlkrkfIatqgPlpntvedFwrmvweqgvtvivmLtele

------------------------------HSDHYKVYNLCSERSYDPSIFHNQVERILI-DDHNVP-RLSQLLYFCHNVREWLDkDPSNVIAVHCKGGK
                              . .......|. | ..|.  .....   .  .||.||  ...|| |.. |||.|. ||.....|||..|.
elgrekcaqYwplgetltygdftvtllseeelagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfleavreale.dpggpvlVHCsaGv

GRTGTAICAWLIA----SGQFEQAQHSLEYFGVRRtdysvgktYQGVQTPSQGRYVGYLEQIFTKLNRRMPPAVTLKLKTIKID
||||| |.|.|.      ...  ... ....  .|        ...||||.| |.. .... . | .  ..||  |||| .|. 
gRtGtfiaaylmleqlekeggvdveeavkelreqR........pgavqtpeqyrflydalleylkrkltlepaselklkllkll
0049260 (Phosphotyrosine protein) phosphatases II 237-390 3e-28 93.8 In-house 5-148 (152) alignment 
Range on Protein: 237-390
Range on HMM: 5-148/152.0
IAMSFPSSGKHKMYRNPISEVARFLDTKHSDHYKVYNLCSERSYDPSIFHNQVERILIDDHNVPRLSQLLYFCHNVREWLDKDPSNVIAVHCKGGKGRTG
.||.|.  . . ...|..... |.| . . ... ... ..|. ..   .. |. .. ..||.|| |||||.|.. . |.| .|......|||..|.||||
yampfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyiqylhlpwpDhgvpdlsqlllflllfieklaldkggpvlVHCsaGvgRtg

TAICAWLIAsgQFEQAQHSLEYFGVRRtdysvgktYQGVQTPSQGRYVGYLEQI
| ..|.|.   .   ... ....  .|         ..|..|.| |.. . |..
tlvaaylml..lgvsleeavalvrekR........pgavpnpgqlrflyefekl
0046845 (Phosphotyrosine protein) phosphatases II 212-393 4.3e-28 93.9 In-house 26-275 (284) alignment 
Range on Protein: 212-393
Range on HMM: 26-275/284.0
MISQNKRRYQQ-----------------------------DGFDLDLTYVTERVIAMSFPSSG-----------------------------KHKMYRNP
   ..| ||..                             ||.||||||.. . ||...| ..                             |.  |...
penlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweqnvrvIVmltelvengrekcaqYwpl

ISEVARF-------LDTKHSDHYKVYNLCSERS--YDPSIFHNQVERILIDDHNVPR-LSQLLYFCHNVREWLDK-DPSNVIAVHCKGGKGRTGTAICAW
..|| ..       |.... |.|.|..|. ..    ..|.....   . . ||.||  ...|| |.. |||.|.. .....|.|||..|.||||| |...
egevltygdftvtllseevkddytvrtleltnlgytgesrtvthfhytswpdhgvppspedlleflrlvrellenlpgggpivVHCsaGvgRtGtfiald

LIASGQFEQA-------QHSLEYFGVRRtdysvgktYQGVQTPSQGRYVGYLEQIFTK
|. .   ..        .. . ..  .|        .. |||..| |.| .. . . |
llleqlekeglllgvdvleavkrlreqR........pgmvqtleqyrfvyealleylk
0045450 (Phosphotyrosine protein) phosphatases II 208-390 7.4e-27 90.3 In-house 49-302 (307) alignment 
Range on Protein: 208-390
Range on HMM: 49-302/307.0
ATRRMISQNKRRYQQ-------------------------------------DGFDLDLTYV----------------------------------TERV
....  ...|.||.                                      ||.||.....                                  . . 
iallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydlkrkfIatqgPlpetvedFwrmlweqgvtvivmltelvelgrek

IAMSFPSSGKHKMYRNpisEVARFLDTKHSDHYKVYNLCSER--SYDPSIFHNQVERILIDDHNVP-RLSQLLYFCHNVREWLDKD-PSNVIAVHCKGGK
.|. .|..| ...|.|    . ..|...| |.|.|..|. ..    ..|.....   .   ||.||  ...|| |.. ||..|... ......|||..|.
caqywPdegeeltygn...ftvtllseehldgytvrtlevtdldgtgesrtvthfhytgwpdhgvppsfeelldfieevrkaleelpkggpvlVHCsaGv

GRTGTAICAWLIASGQF-------EQAQHSLEYFGVRRtdysvgktYQGVQTPSQGRYVGYLEQI
||||| |.|.|. ..           ... ....  .|        ...||.|.| |.. .... 
gRtGtfiaaylmlrqlekegtlldvdlleavkllreqR........pgavqnpeqyrflyealle
0040439 (Phosphotyrosine protein) phosphatases II 209-389 2.5e-26 88.3 In-house 6-243 (249) alignment 
Range on Protein: 209-389
Range on HMM: 6-243/249.0
TRRMISQNKRRYQ---------------QDGFD--------LDLTYVTERVIAMSFPSSGKHKMYRNPISE-----------------------------
.... ...|.||.               ...|.        .|..|.. |.||...| ..  . ... . |                             
allpenkdknrypdilpydhsrvklsilpglflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywplggs

------VARFLDTKHSDHYKVYNLCSER-SYDPSIFHNQVERILIDDHNVP-RLSQLLYFCHNVREWLDKD-PSNVIAVHCKGGKGRTGTAICAWLI---
      . ..|.....|.|.|..|. ..  ...|.  ...  . . ||.||  ...|| |.. ||..|... ......|||..|.||||| |.|.|.   
leygdftvtllsvevkddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaaylmleq

--ASGQFEqAQHSLEYFGVRRtdysvgktYQGVQTPSQGRYVGYLEQ
    ...  ... ....  .|        ...||.|.| |.. ....
lekelgvd.leeavkllrsqR........pgavqnpeqyrflyeall
0051082 (Phosphotyrosine protein) phosphatases II 227-384 4.4e-23 77.0 In-house 6-144 (151) alignment 
Range on Protein: 227-384
Range on HMM: 6-144/151.0
LDLTYVTERVIAMSFPSSgkhkmyrnpisEVARFLdtKHSDHYKVYNLCS--ERSYDPSIFHN---QVERILIDDHNVPRLSQLLYFCHNVREWLDKDPS
....|||........|..           .. ..|  |. ... ..||.|  || |.|.....   .| .| |.|. .| |.... .. .. |.|.....
infsyvtgglyrsggpla...........dflell..kelgiktivnlrseeergycpeylpelgievlhipildwpdpglplsfdavleflellldkkn

NVIAVHCKGGKGRTGTAICAWLIASGqfEQAQHSLEYFGVRRTdysvgktyqGVQTPSQGRYV
....|||..||||||| ....|.. |    ..  ||..  .|.         || .|.|....
gpvlvHCsaGkgRTGtlvalylmllg..vsleealeeyrlkrp.........gvvqpnqqflf
PTEN_C2 C2 domain of PTEN tumour-suppressor protein 400-536 9.9e-23 71.8 Pfam-A 2-133 (134) alignment 
Range on Protein: 400-536
Range on HMM: 2-133/134.0
PAVTLKLKTIKIDGIGGVGNGDGKDLRLEVIINSSVVCHMSCSEGQPGQYfedLDKLVIAVGETDCpSLTGDIKIKFYSNNPNvpVGYDHCAFYFWFHTS
. ..|.|| | . ||  . ...| .. ..|. .. .| ... |  .. ..    .| .|   .  .  . ||....|......  . .. . |..||.||
npkrlelksiilegiPnfktrggckpkvkvyngkkkvfkelasykdster...raktfivkepnrl.pveGDvlveflhkdsk..lpkkekifrvwFNTs

FIE--NYRLFLRREELDNPHKPKvWKVYKETFAVDITFH
|||  ...| |...|||...| | .| ... |.|.. | 
FieknqnvltlpkneLDkalkdk.dkkfsknfkvelvfe
0045098 (Phosphotyrosine protein) phosphatases II 222-391 1.8e-22 75.5 In-house 2-271 (278) alignment 
Range on Protein: 222-391
Range on HMM: 2-271/278.0
QDGFDLDLTYVTERVIAMSFPSSGKHKMYRNPIS------------------------------------------------------------------
.....|||.. .|.......||.  . .|.....                                                                  
ealasldlllefefllllgipseitpalylgnldknRykdilpydhsrVkdYINAsyidgypkkfIatqgPlpstvadfwrmlwelgitvivmltelvel

-------------------------EVARFlDTKHSDHYKVYNLCSERSYDPSIFHNQVERILIDDHNVPRLS---QLLYFCHNVREWLD----------
                         .. .. |. .  ...|.||..||....| . ...  . ..||.|| |.   ..| ..  .||.|.          
grekcaqywpeggsltygdftvtllseevl.ddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllssl

--KDPSNVIAVHCKGGKGRTGTAICAWLIASG--QFEQAQHSLEYFGVRRtdysvgktYQ-GVQTPSQGRYVGYLEQIF
   |......|||. |.||||| ..|.|. .   .   ... ....  .|         .  ||...| |.. .... .
llldsggpvlVHCsaGvgRtGtlvaaylmlelleggvdlleavkelrsqR........pglavqnleqyrflyefllel
0048179 (Phosphotyrosine protein) phosphatases II 241-389 2.4e-22 74.6 In-house 3-142 (144) alignment 
Range on Protein: 241-389
Range on HMM: 3-142/144.0
FPSSGKHKMYRNPISEVARFLDTKHSDHYKVYNLCSERSYDPSIFHN-QVERILIDDHNVPRL-SQLLYFCHNVREWLDKDpsNVIAVHCKGGKGRTGTA
.||    ..|....  . ..   |. ... |.||..|. ..  .... |. .. ..||.|| | ..|| |.. ..|.|...  ....|||..|.||||| 
npseilpglylgslptaldlellkklgittvinlteeyepefleregiqylhlpwpDhgvpdllellleflefieealeeg..gpvlVHCsaGvgRtgtl

ICAWLIASGQfEQAQHSLEYFGVRRTdysvgktyQGVQTPSQGRYVGYLEQ
..|.|.   .   ... |...  ||         ..|..|.| |.. ..|.
vaaylmkklg.lsleealalvrsrrp........gavpnpgqlrfLleyek
0048076 (Phosphotyrosine protein) phosphatases II 241-389 8.8e-22 72.8 In-house 3-140 (145) alignment 
Range on Protein: 241-389
Range on HMM: 3-140/145.0
FPSSGKHKMYRNPISEVARFLDTKHSDHYKVYNLCSERSYDPsIFHNQVERILIDDHNVPRL-SQLLYFCHNVREWLDKDpsNVIAVHCKGGKGRTGTAI
.||   ...|....  . ..   |. ... |.||.||...    .. |. .. ..||.|| | ..|| |.. ..|.|...  ....|||. |.||||| .
wpseilpglylgslptaldlellkdlgittvlnltselelle.rlgiqylylpwpDhgvpdllellleflefieealkeg..gpvlVHCsaGvgRtgtlv

CAWLIASGQfEQAQHSLEYFGVRRtdysvgktYQGVQTPSQGRYVGYLEQ
.|.|. . .   ... ||..  .|         ..|..|.| |.. ..|.
aaylmlllg.vsleealelvrsqr........pgavpnpgqlrflyefel
0044763 (Phosphotyrosine protein) phosphatases II 217-395 6.9e-21 70.1 In-house 11-174 (178) alignment 
Range on Protein: 217-395
Range on HMM: 11-174/178.0
KRRYQQDGFDLDLTYVTERVIAMSFPSSGKHK-MYRNPISEVARFLDTKHSDHYKvynlcsERSYDPSIFHNQVERILIDDHNVPR-LSQLLYFCHNVRE
.... . .. .............|.|..   . .... |. . .. ....  ..|      .  |.|. .. |. .| |.||.||  |...| |.. ..|
nleglersdyinaseilpglylgslppaddlellkelgithivnlteelelgflk......cdpywpeeagiqylhipipDhgvpdllehflefvefiee

WLDKDPsNVIAVHCKGGKGRTGTAICAWLIASGQFeQAQHSLEYFGVRRtdysvgktYqGVQTPSQGRYVGYLEQIFTKLN
.||... ....|||. |.||.|| ..|.|. . ..  ... .|..  ||          .|..|.| |.. ..|... | .
aldekg.gpvlVHCsaGvgRsgtlvaaylmkklgl.sleeaielvrerR........p.ivpnpgqlrqLyefelrllkes
0049772 (Phosphotyrosine protein) phosphatases II 235-364 2.5e-19 65.6 In-house 122-255 (314) alignment 
Range on Protein: 235-364
Range on HMM: 122-255/314.0
RVIAM---------------------SFPSSGKHkmyrnpisevaRFLDTKHSDHYKvynlcsERSYDPSIFHNQ---VERILIDDHNVPRLSQLLYFCH
|.| |                       . .|..            ... .. ...|      |. |||. | ..   . || ..|...| |.... |..
rdivmsrdevladelsrLdaAlgKtpllildgng...........neptaadlellk......eelydpelferlgikylripvpDgsaplledfdefle

NVREWldkDPSNVIAVHCKGGKGRTGT-AICAWLIASGQFeQAQHSLEYFGVRRT
 ..|.   |. ....||||.||||||| ...|.|.   ..  ..  ||..  .|.
fieea...dkggpvlvHCkaGkgRtgtfvvaaylmkllgv.sleealedvrlkRp
0047943 (Phosphotyrosine protein) phosphatases II 259-384 2.6e-19 65.2 In-house 140-264 (273) alignment 
Range on Protein: 259-384
Range on HMM: 140-264/273.0
RFLDTKHSDHYKVYNLCSER-SYDPSIFHNQVERILIDDHNVP-RLSQLLYFCHNVREWLDKD-PSNVIAVHCKGGKGRTGTAICAWLI-----ASGQFE
..|.... |.|.|..|. .. ... | . ...    . ||.||  |..|| |.. ||..| ..  .....|||..|.||||| |...|.     . |.. 
tllseetkddytvrtleltnlgtgesrtvthfhytgwpdhgvppslesllefielvrkalealpsngpvvVHCsaGvgRtgtfialdllldqlekeggvd

qAQHSLEYFGVRRtdysvgktYQGVQTPSQGRYV
 .   . ..  .|        . .||||.| |..
.vleavkllrsqR........pgmvqtpeqyrfl
0051299 (Phosphotyrosine protein) phosphatases II 257-351 2.2e-18 62.2 In-house 150-249 (288) alignment 
Range on Protein: 257-351
Range on HMM: 150-249/288.0
VARFLDTKHSDHYKVYNLCSER-----SYDPSIFHNQVERILIDDHNVPR-LSQLLYFCHNVREWLDkDPSNVIAVHCKGGKGRTGTAICAWLIASGQFE
. ..|.... |.|.|..|. ..       . |.. ..   . . ||.||  ...|| |.. ||..|  .......|||. |.||||| |...|. .   .
tvtllseevlddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpdspellldflrlvrkala.sgggpvvVHCsaGvgRtgtfialdllleqlek

Q
.
e
0036941 (Phosphotyrosine protein) phosphatases II 240-401 1e-17 59.8 In-house 123-286 (297) alignment 
Range on Protein: 240-401
Range on HMM: 123-286/297.0
SFPSSGKHKMYRNPIseVARFLDTKH--SDHYKVYNLCSER-SYDPSIFHNQVERILIDDHNVPR-LSQLLYFCHNVREWLDKD-PSNVIAVHCKGGKGR
 .|.   . .. ...  . ..|....  .|.|....|. .   ...| . ..   . ..||.||   ..|| |.. ||..|..  ..... |||..|.||
ywpleegesltygdf..tvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfielvrkvlkllpsggpvlVHCsaGvgR

TGTAICAWLI--------ASGQFEQAQHSLEYFGVRrtdysvgktYQGVQTPSQGRYVGYLEQIFTKLNRRMPPA
.|| |.|.|.          |..   .  ...   |         .. |||..| |.. .... . | .. ..|.
sgtfiaadlmlqqledklkeggvdileavkklReqR.........pgavqtleqyrflyeallellkkkltkepl
0050432 (Phosphotyrosine protein) phosphatases II 259-345 1.8e-15 52.6 In-house 171-256 (308) alignment 
Range on Protein: 259-345
Range on HMM: 171-256/308.0
RFLDTKHSDHYKVYNLCSER-SYDPSIFHNQVERILIDDHNVPR-LSQLLYFCHNVREWLdkdPSNVIAVHCKGGKGRTGTAICAWLIA
..|.... |.|.|..|. .  ....|.. ..   .   ||.||  ...|| |.. ||..|   |...|.|||. | ||||| |...|. 
tllseevlddytvrtleltnlgdgesrtvthfhytnWpdhgvPpspeilldflelvrksl...pggpivVHCsaGvGRtGtfialdlll
subfamily_DSP11_pd Subfamily DSP11 277-363 7.8e-11 36.2 In-house 67-157 (178) alignment 
Range on Protein: 277-363
Range on HMM: 67-157/178.0
ERSYDPSIFHNQ---VERILIDDHNVPRLSQLLYFCHNVREWLD--KDPSNVIAVHCKGGKGRTGTAICAWLIASGQFEqAQHSLEYFGVRR
.| |... ....    ... .  |.||.   .  |...|.|.|.  ||  ..|.|||  |  |||  || .||   ..| .....| |   |
dryykkkeltdegvkylklncpGhevpkeelvkkfkeavkefleknkdndkligvhCthGvnrtGyliCrylidvegye.pedaieafeear
0051429 (Phosphotyrosine protein) phosphatases II 265-350 1.4e-10 36.8 In-house 99-179 (272) alignment 
Range on Protein: 265-350
Range on HMM: 99-179/272.0
HSDHYKVYNLCSER--SYDPSIFHNQVERILIDDHNVPRlSQLLYFCHNVREwldkdpSNVIAVHCKGGKGRTGTAICAWLIASGQFE
. ..| ...|. ..  |.. .  . .   . . ||.||. ..|| . . ...      .. . |||..||.||||.....|.. |  .
llldyilrellltlllsagearevmhlhytdwpdhgvpq.eallellellld......ggpvlvHCsaGkdRTGtvvallllllgvsl
PTPc_DSPc_SM00012 289-350 1e-09 33.9 In-house 5-68 (105) alignment 
Range on Protein: 289-350
Range on HMM: 5-68/105.0
VERILIDDHNVPR-LSQLLYFCHNVREWLDKDP-SNVIAVHCKGGKGRTGTAICAWLIASGQFE
..   . ||.||.  . .| ....|...  |   |. . |||. | ||||| ... .. .   .
yhytgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqlek
subfamily_RNGTT_pd Subfamily RNGTT 277-363 2.2e-09 31.3 In-house 65-154 (189) alignment 
Range on Protein: 277-363
Range on HMM: 65-154/189.0
ERSYDPSIFHN---QVERILIDDHNV-PRLSQLLYFCHNVREWLDKDPSNVIAVHCKGGKGRTGTAICAWLIASGQFEqAQHSLEYFGVRR
.| || . ...   .  .. .  . . |   |   | . |.|. .| |..||.|||. |  |||  |...|.   ... ...... |   |
sryYdkeelekegikyvklqcagkgeaPeaeqvkefiklveeffkknpeevigvhCthGfnRtGFlivsyLvekedws.veaavalFakaR
subfamily_PTPDC1_pd Subfamily PTPDC1 279-357 1.8e-08 29.1 In-house 72-149 (182) alignment 
Range on Protein: 279-357
Range on HMM: 72-149/182.0
SYDPSIFHNQ---VERILIDDHNVPRLSQLLYFCHNVREWLDKDpsnVIAVHCKGGKGRTGTAICAWLIASGQFEqAQHSLE
|||.  . .|   |  . ..|..|. | ..|     |   |...    .||||  |.||||  |...|. . ... |.....
sYdlealmeqgiyvynfgwkDygvasleriLdivkvvafalqeg...kvavhChaGlGrtGvliacylvyakrlt.aekaik
Ion_trans Ion transport protein 119-205 5.8e-08 20.5 Pfam-A 1-83 (200) alignment 
Range on Protein: 119-205
Range on HMM: 1-83/200.0
IFSVVIATIFLIELSMRVFALGTF---FFKRWLEVLDLVVVLASFILTVVFAAIT-FEhsyicpfpGRLVVAARFIRVLFFIRIVTGKDQL
|. .|. .||..|  ....||| .   ... .  .||..|||.|..  ... . .  .        ..|. ..|..||| ..|...   .|
ileyvftviftlemllkiialgfkkftylrdpwnilDflvvlpslvslilrllnkesa........egllsvlrllrvlRllrlisriegl
0048567 (Phosphotyrosine protein) phosphatases II 278-350 8.6e-08 26.7 In-house 26-106 (157) alignment 
Range on Protein: 278-350
Range on HMM: 26-106/157.0
RSYDPSIFHNQVERI---LIDDHNVPRLSQLLYFCHNVREWLD--KDPSNVIAVHCKGGK---GRTGTAICAWLIASGQFE
. |.. .|. . . .   .. |.  . |..|  |.. . ..|.  .  ...|||||| |    |||.| |...||   .| 
slynalyFsiddglvyedfffdfGPlnlailyrFilklnkflkilelagkaiavhckaglkkrgrtatLigcYlilhlgft
subfamily_DSP23_pd Subfamily DSP23 288-350 9.3e-08 26.8 In-house 53-113 (148) alignment 
Range on Protein: 288-350
Range on HMM: 53-113/148.0
QVERILIDDHNVPRLSQLLYFCHNVREWLDKDpsNVIAVHCKGGKGRTGTAICAWLIASGQFE
 . |. |||.  | | |.  | . | |  .|.  . ..|||  |.||||| .  .|.   .. 
tlvrlriddyhppaleqvvefvrvveeaeekn..eavsvhcllgrgrtgtmlacylvkerkla
subfamily_CDC14_pd Subfamily CDC14 233-363 1.5e-07 25.6 In-house 177-304 (328) alignment 
Range on Protein: 233-363
Range on HMM: 177-304/328.0
TERVIAMSFPSSGKHKMYRNPISEVARFLDTKHS-DHYKVYNLcSERSYDPSIFHNQ---VERILIDDHNVPRLSQLLYFCHNVREWldkdpSNVIAVHC
 ....|.. | . ...  . |. . ...|.  .. .  .|  |  .. || . | ..    . ..  |  .|  . .  | . . .      .  |||||
PdkflalagPhnkskledgyplhaPeklleyfrknnvttvvrL.nkklYdakkftdaGfdhkDlffiDGstPsdaivkkfleiaeka.....eGaiavhC

KGGKGRTGTAICAWLIASGQFEqAQHSLEYFGVRR
| | ||||| | ..|.   .|  |. .. .. . |
kaGLGrtGtLiacylmkhyrft.aaeaiawlricr
subfamily_PTPRB_pd Subfamily PTPRB 287-341 2.8e-07 24.9 In-house 182-238 (293) alignment 
Range on Protein: 287-341
Range on HMM: 182-238/293.0
NQVERILIDDHNVPRLS-QLLYFCHNVREWLDKDP-SNVIAVHCKGGKGRTGTAICA
.| . .   ||.||  . .|| |...|||...|.  .. | |||  | ||||| |. 
rqyhftsWpdhgvPektktlldfvrtvreaiektaskrPivvhCsaGvGRtGtfial
Y_phosphatase Protein-tyrosine phosphatase 265-346 4.3e-07 25.0 Pfam-A 112-195 (235) alignment 
Range on Protein: 265-346
Range on HMM: 112-195/235.0
HSDHYKVYNLCSERSYDPS---IFhNQVERILIDDHNVP-RLSQLLYFCHNVREWLdKDPSNVIAVHCKGGKGRTGTAICAWLIAS
....| ...|  . . ..|   .. .|.      ||.||   ..|| ....|...  .. |. . |||. | ||||| ...... .
dekeytlrklelkkkkeesekrev.kqlhytnWpdhgvpespkslldlirkveksk.eaksgpvvVhCsaGvgRtgtfvaldille
Y_phosphatase Protein-tyrosine phosphatase 265-346 4.3e-07 25.0 In-house 112-195 (235) alignment 
Range on Protein: 265-346
Range on HMM: 112-195/235.0
HSDHYKVYNLCSERSYDPS---IFhNQVERILIDDHNVP-RLSQLLYFCHNVREWLdKDPSNVIAVHCKGGKGRTGTAICAWLIAS
....| ...|  . . ..|   .. .|.      ||.||   ..|| ....|...  .. |. . |||. | ||||| ...... .
dekeytlrklelkkkkeesekrev.kqlhytnWpdhgvpespkslldlirkveksk.eaksgpvvVhCsaGvgRtgtfvaldille
DSPc Dual specificity phosphatase, catalytic domain 292-368 5.2e-07 24.6 Pfam-A 45-119 (133) alignment 
Range on Protein: 292-368
Range on HMM: 45-119/133.0
ILIDDHNVPRLSQLLYFCHNVREWLdKDPSNVIAVHCKGGKGRTGTAICAWLIASGQFeQAQHSLEYFGVRRTDYSV
| ..|..   .|. |  . .. | . ..  . ..|||. |  |..| |.|.|. . .. .... .|..  ||   | 
ipvedetetkiskeleeavefieka.eqkgkkvlVHCqaGisRSatliiaYlmktknl.slneAyefvkerrskisp
DSPc Dual specificity phosphatase, catalytic domain 292-368 5.2e-07 24.6 In-house 45-119 (133) alignment 
Range on Protein: 292-368
Range on HMM: 45-119/133.0
ILIDDHNVPRLSQLLYFCHNVREWLdKDPSNVIAVHCKGGKGRTGTAICAWLIASGQFeQAQHSLEYFGVRRTDYSV
| ..|..   .|. |  . .. | . ..  . ..|||. |  |..| |.|.|. . .. .... .|..  ||   | 
ipvedetetkiskeleeavefieka.eqkgkkvlVHCqaGisRSatliiaYlmktknl.slneAyefvkerrskisp
subfamily_PTPMT1_pd Subfamily PTPMT1 299-351 1.4e-06 22.8 In-house 87-137 (171) alignment 
Range on Protein: 299-351
Range on HMM: 87-137/171.0
VPRLSQLLYFCHNVREWLDKdpSNVIAVHCKGGKGRTGTAICAWLIASGQFEQ
 | | .|.   . ...  .|   . . ||||.|.||..| . ..|. . ... 
apdleklekgvefiekvask..gkrvYvHCkaGrgRsatlvacylmkkeklsp
subfamily_PTPN12_pd Subfamily PTPN12 288-349 1.8e-06 22.0 In-house 174-234 (290) alignment 
Range on Protein: 288-349
Range on HMM: 174-234/290.0
QVERILIDDHNVPR-LSQLLYFCHNVREWLDKDpSNVIAVHCKGGKGRTGTaICAWLIASGQF
| .     ||.||.  ..|| . ..|||  ... .. ..|||  | ||||| |.|  ..  ..
qfhYtaWPDhgvPssaksllelielvrelqese.daPlvvhCsaGvGrtGt.iiaidyvrell
DSPc_SM00195 267-345 2.2e-06 22.6 In-house 140-219 (263) alignment 
Range on Protein: 267-345
Range on HMM: 140-219/263.0
DHYKVYNLCSERSYD-PSIFHNQVERILIDDHNVP-RLSQLLYFCHNVREWLDKDpSNVIAVHCKGGKGRTGTAICAWLIA
|......|  .   .  . . .|..     ||.||   ...| . . |... ..  |. | |||. | ||||| ... .| 
deiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkksksts.sgpivVhCsaGvgRtgtfvtidiil
PTPc_SM00194 267-345 2.2e-06 22.6 In-house 140-219 (263) alignment 
Range on Protein: 267-345
Range on HMM: 140-219/263.0
DHYKVYNLCSERSYD-PSIFHNQVERILIDDHNVP-RLSQLLYFCHNVREWLDKDpSNVIAVHCKGGKGRTGTAICAWLIA
|......|  .   .  . . .|..     ||.||   ...| . . |... ..  |. | |||. | ||||| ... .| 
deiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkksksts.sgpivVhCsaGvgRtgtfvtidiil
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 295-340 2.2e-06 22.0 In-house 189-235 (319) alignment 
Range on Protein: 295-340
Range on HMM: 189-235/319.0
DDHNVPR-LSQLLYFCHNVREWLDKDPSNVIAVHCKGGKGRTGTAIC
 ||.||. . .|| . ...|.  .|  |  | |||  | ||||| | 
pdhdvPekatslldllkrirksrektqsgPivvhCsaGvGRtGtfiv
subfamily_PTPN13_pd Subfamily PTPN13 289-344 4.3e-06 21.2 In-house 171-225 (273) alignment 
Range on Protein: 289-344
Range on HMM: 171-225/273.0
VERILIDDHNVPRLS-QLLYFCHNVREWLDkdPSNVIAVHCKGGKGRTGTAICAWLI
.. .   ||.||. . .|| |  .||.  .   .  |.|||  | ||.|| |.   .
lnfvkwPdhgvPssaaellqfvaevrrlqt..dagPivvhcsaGiGrsGtlitidvv
subfamily_PTPN6_pd Subfamily PTPN6 294-397 5.3e-06 20.6 In-house 196-302 (306) alignment 
Range on Protein: 294-397
Range on HMM: 196-302/306.0
IDDHNVPRLSQ-LLYFCHNVREWLDKDP---SNVIAVHCKGGKGRTGTAICAWLIASgQFEQAQHSLEYfGVRRTDYSVGKTYQG-VQTPSQGRYVGYLE
  ||.||.  . .| | ..|..  ..     .  | |||  | ||||| |   .. . . |.     ..  ....  || .  .| ||| .| ..| .  
WPdhgvpkdpgavLdfledvnrkqeeleeaeagpivvhCsaGiGRtGtfiviDillk.liekkgldadi.diqklvksvreqrsglvqteqqykfvykai

QIFTKLNRR
. . . ...
kkyietkkk
Pox_A14 Poxvirus virion envelope protein A14 83-132 6.5e-06 12.6 Pfam-A 14-62 (92) alignment 
Range on Protein: 83-132
Range on HMM: 14-62/92.0
VSWLGLLLVLADVIIVIVDLSTNdTNHTSESYKPLEIFSVVIATIFLIEL
|  .|..|. . .|.  ...| . |. . . .. | | . ... . |. |
vlivGivLLilacifAfiefsks.tkpsdktwralsiiaFilgivlllgl
subfamily_PRL_pd Subfamily PRL 264-348 6.5e-06 20.3 In-house 31-117 (151) alignment 
Range on Protein: 264-348
Range on HMM: 31-117/151.0
KHSDHYKVYNLCsERSYDPSIFHN---QVERILIDDHNVPRLSQLLYFCHNVREWLDKDPSNVIAVHCKGGKGRTGTAICAWLIASGQ
|...  .|   | | .|| . ...   .|  .  || .||  . .  . . ..|   ..|....||||  | ||.   ..  || .| 
kkeevktvvrvc.eptydteklekegievldlafddGavPpeevveeWlellkekfkeepkstvavhcvaGlGraPvlvalalieaGm
PalH PalH/RIM21 83-166 8.1e-06 11.1 Pfam-A 195-278 (348) alignment 
Range on Protein: 83-166
Range on HMM: 195-278/348.0
VSWLGLLLVLADVIIVIVDLSTNDTNHTSESYKPLEIFSVVIATIFLIE--LSMRVFALGTFffKRWLEVLDLVVVLASFILTVVF
. ..||.|.|.|.|. .. . ...|........ |..|....  .  |   ... .. . ..  | .||   ......  ||... 
iflvglililvdqilwailsfkyntkkersasdalpafiylfelalqilyaaivvyYliskk..klaleykeiipLalltillill