Gene NvecPTP-sf1-1 in Nematostella vectensis

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily NvecPTP-sf1
Protein sequence
ID Type Fasta BLAST phosphatome Note
NvecP041_AA protein Get Run
NvecP041_AA_2-241 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 3-241 1.8e-175 575.5 In-house 1-239 (239) alignment 
Range on Protein: 3-241
Range on HMM: 1-239/239.0
EAAKKRVNKAKNRYANIVTYDHSRVVLEKLSNDPHSDYINASYLRDYDGSPKAYIATQGNICINAGDFWRMMWQERRCVIVMLTGLIEGHKKKCHQYWPD
|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||...|..|||||||||||||||||||||||||||||||||||
eaakkrvnkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpd

STSKYCNLRVTLRKTEVFADYIIRTFVMSQVGQTEERYVYQYHFTVWPDKGVPQYATAVLGLRRKITKDSLPGARPWVIHCSAGVGRTGAFLVIDAMLRQ
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
stskycnlrvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcsagvgrtgaflvidamlrq

AKKQKTVDIFNYVKAIREDRPHMVQTSEQYVFIHLAVLE
|||||||||||||||||||||||||||||||||||||||
akkqktvdifnyvkairedrphmvqtseqyvfihlavle
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 4-242 2.4e-175 575.1 In-house 1-239 (239) alignment 
Range on Protein: 4-242
Range on HMM: 1-239/239.0
AAKKRVNKAKNRYANIVTYDHSRVVLEKLSNDPHSDYINASYLRDYDGSPKAYIATQGNICINAGDFWRMMWQERRCVIVMLTGLIEGHKKKCHQYWPDS
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||...|..||||||||||||||||||||||||||||||||||||
aakkrvnkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpds

TSKYCNLRVTLRKTEVFADYIIRTFVMSQVGQTEERYVYQYHFTVWPDKGVPQYATAVLGLRRKITKDSLPGARPWVIHCSAGVGRTGAFLVIDAMLRQA
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
tskycnlrvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcsagvgrtgaflvidamlrqa

KKQKTVDIFNYVKAIREDRPHMVQTSEQYVFIHLAVLEA
|||||||||||||||||||||||||||||||||||||||
kkqktvdifnyvkairedrphmvqtseqyvfihlavlea
subfamily_PTPRD_pd Subfamily PTPRD 2-242 5.8e-116 383.4 In-house 40-280 (564) alignment 
Range on Protein: 2-242
Range on HMM: 40-280/564.0
SEAAKKRVNKAKNRYANIVTYDHSRVVLEKLSNDPHSDYINASYLRDYDgSPKAYIATQGNICINAGDFWRMMWQERRCVIVMLTGLIEGHKKKCHQYWP
 |||.| .||||||||||| ||||||||.|. .|. |||||||..  |. ..|||||||| .     |||||.|... ..||||| | | .|.|||.|||
weaankpaNkaKNRyanivaYdhsRVvLskvegdegsDYINAsfidgyr.krkayIAtqgPlaetiedFWRmvweqnsstiVmltkleEkgkvkchkYWP

DS-TSKYCNLRVTLRKTEVFADYIIRTFVMSQVGQTEERYVYQYHFTVWPDKGVPQYATAVLGLRRKITKDSLPGARPWVIHCSAGVGRTGAFLVIDAML
.. | .| .| ||| ..| .|||.|||| ...  . | | | |.||| |||.|||..||..| |.||... . |.| |.|.||||||||||.|.||||||
ekgtetygeltVtleeeeeladyeirtfklkkkkssesreVrqFhFtsWPdhgvpesatslLdlirkvralnepdagPivVhCSaGVGRTGtfividaml

RQAKKQKTVDIFNYVKAIREDRPHMVQTSEQYVFIHLAVLEA
...|..|||||..||||.|..|..|||| |||.||| |.|||
erikeektvDiyqyvkalrkqRnamVqteeQYiFiheailea
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 10-241 8.3e-102 334.4 In-house 3-237 (237) alignment 
Range on Protein: 10-241
Range on HMM: 3-237/237.0
NKAKNRYANIVTYDHSRVVLEKLSNDphSDYINASYLRDYDGSPKAYIATQGNICINAGDFWRMMWQERRCVIVMLTGLIEGHKKKCHQYWPDS--TSKY
||.||||.|||.||||||||.   ..  ||||||.||...||.|| |||.|| .     |||.|.|||.  ||||||||||| ..|||.|||..   . |
nkiknrygnivaydhsrvvlkgagsg..sdyinatylkgfdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywpstdqpaay

CNLRVTLRKTEVFADYIIRTFVMSQVG-QTEERYVYQYHFTVWPDKGVPQYATAVLGLRRKITKDS--LPGARPWVIHCSAGVGRTGAFLVIDAMLRQAK
  | |.|.| | |.|| .|....|. . . | |...||.||.|||.||||...|.| .|..| . |  .. . ||.||||||||||| ||||||||||||
gvltvslkkkeefsdytvrslllskrltlkevrlihqyqftswpdrgvpqqtaallrfrkniinrsphvsesgpwiihcsagvgrtgiflvidamlrqak

KQKTVDIFNYVKAIREDRPHMVQTSEQYVFIHLAVLE
..| |||.|||..| ||||...|| .|||||| ..||
ekkvvdiynyvysieedrpyiiqtkdqyvfihqtile
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 4-242 1.6e-99 327.2 In-house 3-241 (250) alignment 
Range on Protein: 4-242
Range on HMM: 3-241/250.0
AAKKRVNKAKNRYANIVTYDHSRVVLEKLSNDPHSDYINASYLRDYDGSpKAYIATQGNICINAGDFWRMMWQERRCVIVMLTGLIEGHKKkCHQYWP-D
 |||  || |||||.|...|.||||||| . | .|||||||.|  ||.. ||.||||| .     |||||...|   .||||| | | .|. .||||| .
vakkpqnkeknryadiialdssrvvLekekgdkesdyinasflhgyder.kafiatqgPlqatiedfWrmvleeksgtivmLtnLkesekt.yhqywPve

STSKYCNLRVTLRKTEVFADYIIRTFVMSQVGQTEERYVYQYHFTVWPDKGVPQYATAVLGLRRKITKDSLP-GARPWVIHCSAGVGRTGAFLVIDAMLR
 . || ...|.| ..|.||||..|....|.  ...|| | |.||.||||||||..|||||.|..|. .     |..| ...|||||||.|||..|||.| 
kaekyGdvtvsllskeefadytkrklklskakkaderivrqlhfvvWPdkgvPevatavLellkkvqasqqqagnaPvivqCsaGvgrsGafiaidavle

QAKKQKTVDIFNYVKAIREDRPHMVQTSEQYVFIHLAVLEA
..||.|.||.|...|..|.||||.|.. |||||.. ..|.|
rlkkekvvdvfkvikvlrkdrphavesleqyvfvyeiilka
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 2-242 2e-98 324.3 In-house 48-289 (298) alignment 
Range on Protein: 2-242
Range on HMM: 48-289/298.0
SEAAKKRVNKAKNRYANIVTYDHSRVVLEKLSNDPHSDYINASYLRDYDGSPkAYIATQGNICINAGDFWRMMWQERRCVIVMLTGLIEGHKKKCHQYWP
.|.|.|. || |||||.|...|.||||||| ..| .|||||||.|  |.|.. |.||||. .     |||||...|   .||||| | | .| |.|.|||
kevarkpenkkkNRyadiialdssRvvLekedadeesdYiNAsflhaykgrn.afiatqaPltetvedFWrmvteedigtiVmltnleeldktkyhkywP

D-STSKYCNLRVTLRKTEVFADYIIRTFVMSQVGQTEERYVYQYHFTVWPDKGVPQYATAVLGLRRKITKD-SLPGARPWVIHCSAGVGRTGAFLVIDAM
|  . .| ...|.|...|.|||.|.|.. .|.  ...|| | | |||.|||||||..||.||.|.||. .  .  | .| ...|||||||.|.| .||..
degketygeitvsllskeefadlivrklkvskkkeekerevrqlhftsWpdkgvpenatsvldllrkvrasqqqagnkpvivqCsaGvgRsGtfiaidsv

LRQAKKQKTVDIFNYVKAIREDRPHMVQTSEQYVFIHLAVLEA
| ..||...||.|..||..|..||..||| ||||||. |||||
lervkkeqvvDvfqvvkvlRkkrpgavqteeqYvfiyeavlea
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 5-242 2.1e-92 304.6 In-house 41-279 (318) alignment 
Range on Protein: 5-242
Range on HMM: 41-279/318.0
AKKRVNKAKNRYANIVTYDHSRVVLEKLSNDPHSDYINASYLRDYDgSPKAYIATQGNICINAGDFWRMMWQERRCVIVMLTGLIEGHKKKCHQYWPDST
. . |||||||||||..|||.|| |..|.... ||||||.|.  |  . |||||.|. .     |||||.|.   .|||||| . |  |.|.|.|||.. 
slepvnkaknryanilaydhtrvkLqmlegeegsDyinanyidGyr.rkkayiaaqaPlpetieDfWrmvWeqnsavivmltqeeergkakvhryWPskg

S-KYCNLRVTLRKTEVFADYIIRTFVMSQVGQTEERYVYQYHFTVWPDKGVPQYATAVLGLRRKITKDS-LPGARPWVIHCSAGVGRTGAFLVIDAMLRQ
| .| .|.|.|...  ..||..|.| ... .. |.| | |||.| |||.|||. .. .| | |...|    .||.| |.|||||||||| |...|..|..
srsygklvvelkeevelsdyvlrefkvtrteeeesrqvrqyhytsWpdegvpesgaslldlvrqvskaqqksgagpivvhCsaGvGrtGvfiavdiller

AKKQKTVDIFNYVKAIREDRPHMVQTSEQYVFIHLAVLEA
.|....||.|..|| .|| |. |||| .||.||. ..|||
ikaealvDvfqtvkqlreqrnlmvqtedqyefiydvllea
subfamily_PTPRB_pd Subfamily PTPRB 3-241 1.3e-86 285.3 In-house 44-283 (293) alignment 
Range on Protein: 3-241
Range on HMM: 44-283/293.0
EAAKKRVNKAKNRYANIVTYDHSRVVLEKLSNDPHSDYINASYLRDYDgSPKAYIATQGNICINAGDFWRMMWQERRCVIVMLTGLIEGHKKKCHQYWPD
.||.. ||.||||| ||..|||||| |..|.....||||||.|...|  ||. .||||| .     |||||.|...  .||||| |.|. |.||..|||.
kaaelavnraknrytnilpydhsrvkLaalkdesgsDYinanyipgyn.sprefiatqGPlpetvddfWrmvwekkssiivmltqlvekgkvkCeeYWPa

S--TSKYCNLRVTLRKTEVFADYIIRTFVMSQvgQTEERYVYQYHFTVWPDKGVPQYATAVLGLRRKITKDS--LPGARPWVIHCSAGVGRTGAFLVIDA
   .  | ...||| ..|.  |..||.. ...  ..||| | ||||| ||| |||. ....| . |.. .       .|| |.||||||||||.|. .| 
deepvlyGdikvtlvaeeeledwvirelkiek..ekeerkvrqyhftsWpdhgvPektktlldfvrtvreaiektaskrPivvhCsaGvGRtGtfialdr

MLRQAKKQKTVDIFNYVKAIREDRPHMVQTSEQYVFIHLAVLE
.|.. ... .||||  | ..||.| ..||| .||.||| .||.
llqaieeedyvdifgivaelReeRnllvqtekqYifihqcvld
0050432 (Phosphotyrosine protein) phosphatases II 3-241 2e-85 282.1 In-house 61-297 (308) alignment 
Range on Protein: 3-241
Range on HMM: 61-297/308.0
EAAKKRVNKAKNRYANIVTYDHSRVVLeklsnDPHSDYINASYLRDYD-GSPKAYIATQGNICINAGDFWRMMWQERRCVIVMLTGLIEGHKKKCHQYWP
..|..  || |||| .|. ||||||.|     |..|||||||| . |. ..|...|||||    . .|||||.|...  |||||| |.|  ..||.||||
svallpenkdkNrykdilpydhsRVkl.....degsdYInAsyvdgyssklprkfIatqgPlpntvedFwrmvweqnvrvIvmLtklvengrekcaqYwp

D----STSKYCNLRVTLRKTEVFADYIIRTFVMSQVGQTEERYVYQYHFTVWPDKGVPQYATAVLGLRRKITKDSlpGARPWVIHCSAGVGRTGAFLVID
.    .. .| ...|||...||..||..||. .. .|  |.|.|...|.| ||| |||......| . ... |    .  | |.||||||||||.|...|
lelgggsleygkftvtllseevlddytvrtleltnlgdgesrtvthfhytnWpdhgvPpspeilldflelvrksl..pggpivVHCsaGvGRtGtfiald

AMLRQAKKQKTVDIFNYVKAIREDRPHMVQTSEQYVFIHLAVLE
 .|.| .|...||.|..|| .|| ||.|||| |||.|.. |.||
llleqlekeggvdvfeavkklReqRpgmvqtpeqylflyralle
0051299 (Phosphotyrosine protein) phosphatases II 4-241 2.4e-85 281.8 In-house 43-284 (288) alignment 
Range on Protein: 4-241
Range on HMM: 43-284/288.0
AAKKRVNKAKNRYANIVTYDHSRVVLEKLSNDPHSDYINASYLRDYDGSPKaYIATQGNICINAGDFWRMMWQERRCVIVMLTGLIEGHKKKCHQYWP-D
||..  |. |||| .|. ||||||.|  |.....||||||||.. |. . | .|||||    . .|||||.|...  ||||||.|.|  ..||.|||| .
aallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyidgynlkrk.fIatqgPlpntvedFWrmvweqnvrvIvmltklvelgrekcaqYwplg

STSKYCNLRVTLRKTEVFADYIIRTFVMSQV----GQTEERYVYQYHFTVWPDKGVPQYATAVLGLRRKITKDSLPGARPWVIHCSAGVGRTGAFLVIDA
.. .| ...|||...||..||..||. .. .    |. |.|.|...|.| ||| |||......| . |.. |   .|  | |.||||||||||.|...| 
gsltygditvtllseevlddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpdspellldflrlvrkalasgggpvvVHCsaGvgRtgtfialdl

MLRQAKKQKTVDIFNYVKAIREDRPHMVQTSEQYVFIHLAVLE
.|.| .|...||....|| .|| ||.|||| |||.|.. |.||
lleqlekeggvdvleavkrlreqRpgmvqtpeqyrfvyealle
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 4-242 4.7e-84 277.2 In-house 42-282 (319) alignment 
Range on Protein: 4-242
Range on HMM: 42-282/319.0
AAKKRVNKAKNRYANIVTYDHSRVVLEKLSNDPHSDYINASYLRDYDGSpKAYIATQGNICINAGDFWRMMWQERRCVIVMLTGLIEGHKKKCHQYWPDS
 |.|  || |||| ||..||..|||| .| . . |||||||..  |.   ...||||. .     |||||.|.|.  ..||||.| |  | |...|||. 
saskeenkkknryqnilaydrtrvvlseldgvegsdyinasfidgyqer.ekfiatqaPlentiedfWrmvWeeessivvmltklveklkvklkkywpee

T-SKYCNLRVTLRKTEVFADYIIRTFVMSQ-VGQTEERYVYQYHFTVWPDKGVPQYATAVLGLRRKITKDS-LPGARPWVIHCSAGVGRTGAFLVIDAML
.  .| .| ||| . |  .||||| . . .  .. | | | ....| |||..||..||..| | ..| |    . ..| |.||||||||||.|.|.||||
nfeeyGrlivtleeeeeledyiirklklnkkssevetRevkhfqyteWpdhdvPekatslldllkrirksrektqsgPivvhCsaGvGRtGtfivldaml

RQAKKQKTVDIFNYVKAIREDRPHMVQTSEQYVFIHLAVLEA
 . |.. ..|.|..|. .|  |. |||. ||| ||. |.|||
ervkeegvlDvfstvsrlRtqRnimvqrpeqYkfiyeallea
subfamily_PTPRK_pd Subfamily PTPRK 3-242 9.6e-84 275.9 In-house 36-276 (314) alignment 
Range on Protein: 3-242
Range on HMM: 36-276/314.0
EAAKKRVNKAKNRYANIVTYDHSRVVLEKLSNDPHSDYINASYLRDYDgSPKAYIATQGNICINAGDFWRMMWQERRCVIVMLTGLIEGHKKKCHQYWPD
.||||  |..|||. .|..||.|||.|  . .||.||||||...  |   |.|.|.||| .     ||||....|. . ||||| |.|  . || .|||.
daakkdenreknrsgdilaydrsrvflitidgdpssdyinaalidsyk.rpaafivtqgPlqetvkdfWrlvydencasivmltelvevgrvkClkyWPe

STSKYCNLRVTLRKTEVFADYIIRTFVMSQ--VGQTEERYVYQYHFTVWPDKGVPQYATAVLGLRRKITKDSLPGARPWVIHCSAGVGRTGAFLVIDAML
 |..| ...|.| .||. |....|.| ...   || | | | |..|. ||| .||..||..|.| |.. | . ..| . |.||||| ||||.|..|| .|
dtevygdikvelvetellaelvvrifrveklargqeeirevrqfqflgWpdhdvPvsatgllklvrrvkksqeeeaGrivvhCsaGaGrtGtfiaidivl

RQAKKQKTVDIFNYVKAIREDRPHMVQTSEQYVFIHLAVLEA
  ......||.|| ||..|. .. ||.| |||.||. ..|||
dmieregvvdvfnavktlrsrkvnmveteeqykfiydvilea
0046845 (Phosphotyrosine protein) phosphatases II 3-241 2.3e-82 271.9 In-house 21-272 (284) alignment 
Range on Protein: 3-241
Range on HMM: 21-272/284.0
EAAKKRVNKAKNRYANIVTYDHSRVVLEKLSND-PHSDYINASYLRDYD----GSPKAYIATQGNICINAGDFWRMMWQERRCVIVMLTGLIEGHKKKCH
..|..  |. |||| .|. ||||||.|  |..| ..||||||||.. ||     ..|..|||||    . .|||||.|...  ||||||.|.|  ..||.
svallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweqnvrvIVmltelvengrekca

QYWP--DSTSKYCNLRVTLRKTEVFADYIIRTFVMSQVG-QTEERYVYQYHFTVWPDKGVPQYATAVLGLRRKITKDSL--PGARPWVIHCSAGVGRTGA
||||  ... .| ...|||...||. ||..||. .. .|   |.|.|...|.| ||| |||.... .| . |.. .     ||  | |.||||||||||.
qYwplegevltygdftvtllseevkddytvrtleltnlgytgesrtvthfhytswpdhgvppspedlleflrlvrellenlpgggpivVHCsaGvgRtGt

FLVIDAMLRQAKKQK---TVDIFNYVKAIREDRPHMVQTSEQYVFIHLAVLE
|...| .|.| .|..   .||....|| .|| ||.|||| |||.|.. |.||
fialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyealle
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 5-241 2.6e-82 271.4 In-house 41-281 (305) alignment 
Range on Protein: 5-241
Range on HMM: 41-281/305.0
AKKRVNKAKNRYANIVTYDHSRVVLEKLSNDPHSDYINASYLRDYDGSpKAYIATQGNICINAGDFWRMMWQERRCVIVMLTGLIEGHKKKCHQYWPDST
 || .||||||...|...|..|. | . .....||||||||.  |... |.||..|| .     ||||....|.  .|||||.|.|| |.||.||||.|.
gkkeankaknrlkeitlldddriiltekeslddsdyinasyvdgykrk.kkyivaqgPlkntvadfWrliveekvstivmltklveggkdkCrqYWpesk

SK---YCNLRVTLRKTEVFADYIIRTFVMSQ-VGQTEERYVYQYHFTVWPDKGVPQYATAVLGLRRKITKDSLPGAR-PWVIHCSAGVGRTGAFLVIDAM
..   . .. |.|. .. ..|||.| . .|.  .. |.| | ||..| |||.||||.||..| | ....||   .   | ..||||||||||.|...| .
tekkefgefsvelksektasdyieRklkisiededkesrtvlqyqltdWPdhGvpqfatsllslikrvqkdqkkdkgvpllVhCsagvgRtGvfiavdia

LRQAKKQKTVDIFNYVKAIREDRPHMVQTSEQYVFIHLAVLE
| ..|| ..||.|...|..|. |. |||| .||||.| |. |
lerlkkEevvdvfevlkqlRskrmkmvqtldqYvflhdalde
subfamily_PTPRA_pd Subfamily PTPRA 3-241 1.1e-81 269.2 In-house 51-293 (330) alignment 
Range on Protein: 3-241
Range on HMM: 51-293/330.0
EAAKKRVNKAKNRYANIVTYDHSRVVLEKLSNDPHSDYINASYLRDYDGSpKAYIATQGNICINAGDFWRMMWQERRCVIVMLTGLIEGHKKKCHQYWPD
|.|.|  || |||. ||. ||.|||.| ...  ..|||||||..  |    . .||.||       |||||.|. . . ||||| | | ...||.|||||
elaskeenkeknrvvnilPydfsrvilsvkeGveesdyinasfidGykek.dkfiaaqGPkeetvedfwrmiweqksativmltelkerkeekcaqywPd

ST-SKYCNLRVTLRKTEVFADYIIRTFVMSQVGQTE----ERYVYQYHFTVWPDKGVPQYATAVLGLRRKITKDSLPGARPWVIHCSAGVGRTGAFLVID
     | |.||......|  || .| |.. |....     .| | |.||| ||| |||  .  .| | .|. |     | | |.||||||||||.|.|.|
eGlvtyGnirvevedetvlvdytvrkflvqqlpdatrekksrlvrqfhftswPdvGvPfepiGmlkllkkvkklnqqsagpivvhcsaGvGrtGtfivld

AMLRQAKKQKTVDIFNYVKAIREDRPHMVQTSEQYVFIHLAVLE
|.| . | .. ||.|. || .|  ||.|||| |||.||. ..||
avlervkaerkvdvfefvkrlrlqrpqmvqtdeqyefiykvlle
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 3-240 1.1e-81 269.0 In-house 40-276 (288) alignment 
Range on Protein: 3-240
Range on HMM: 40-276/288.0
EAAKKRVNKAKNRYANIVTYDHSRVVLEKLSNDPHSDYINASYLRDYDgSPKAYIATQGNICINAGDFWRMMWQERRCVIVMLTGLIEGHKKKCHQYWPD
.|... ||. |||| ||..||. || |.|| . . .|||||||. ... . |.|||||| .    .|||.......   |||||.|.|| |.||..||||
tagrlavnakknRyrnilpyDekrvklkkleeeagaDYinasyidgek.kkkkyiatqgPladtvndfWelvyenktstivmltelveggktkCeeYWPd

STS--KYCNLRVTLRKTEVFADYIIRTFVMSqvGQTEERYVYQYHFTVWPDKGVPQYATAVLGLRRKITKDSLPGARPWVIHCSAGVGRTGAFLVIDAML
.    .| .. |||....   |.. |.. .    ...|. . ||....|||.|||. .. .|.|.|..   .   . | ..|||||||||| |...||..
adkpknyGsvtvtlveskeledfvlrkllle..kkkteleitqyqylaWpdhgvPeskapllellrqvkvanqadtgpiivhCsaGvGrtgtFialdali

RQAKKQKTVDIFNYVKAIREDRPHMVQTSEQYVFIHLAVL
 . ......|... |. .|. |. .||| .||.||. ..|
daveeedyiDvagtvaklRkqRallvqtlkqYefiyevll
subfamily_PTPRG_pd Subfamily PTPRG 2-242 1.6e-81 269.3 In-house 39-286 (563) alignment 
Range on Protein: 2-242
Range on HMM: 39-286/563.0
SEAAKKRVNKAKNRYANIVTYDHSRVVLEKLSNDPHS-DYINASYLRDYDgSPKAYIATQGNICINAGDFWRMMWQERRCVIVMLTGLIEGHKKKCHQYW
 |...|. || |||| |||.||.||| |..|..  .. |||||.|.  |    ||.||||| .   . |||||.|...  .|||.| | | ...||..||
aehsqkpenkrKnRylnivaydrsRvklsplpgkkkklDYinAnyidGyq.kskafiatqgplkdtfddFWrmiWeqnvaiivmitnlvergrrkcdvYW

PDS-TSKYCNLRVTLRKTEVFADYIIRTFVMSQ----VGQ--TEERYVYQYHFTVWPDKGVPQYATAVLGLRRKITKDSLPGARPWVIHCSAGVGRTGAF
|   . .| .|.||| ..||.| | .||.|. .     ..   .|. |.|||.| |||.|||.... ||   .|  .     | | |.|||||||||| .
PkdesetygalqvtlieeevlalytvrtlviknlklkkkkqcdteklvrqyhytkWPdhgvPehslpvLifvkkssaankaeaGPivvHcsaGvgrtGty

LVIDAMLRQAKKQKTVDIFNYVKAIREDRPHMVQTSEQYVFIHLAVLEA
.|.|..|.| .....|..|. .| ||  |...||| |||.|.| |.|||
ivldtllkqiqqenavnvfgflkhiraqRnflvqteEqYiflhdallea
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 2-241 4.9e-80 263.8 In-house 41-277 (315) alignment 
Range on Protein: 2-241
Range on HMM: 41-277/315.0
SEAAKKRVNKAKNRYANIVTYDHSRVVLEKLSNDPHSDYINASYLRDYDgSPKAYIATQGNICINAGDFWRMMWQERRCVIVMLTGLIEGHKKKCHQYWP
 . |||  || |||| ||..||.||| |  | |||||||.||...  |.  .. |||.||      .||||....|    |||||.|.||.|.|. .|||
ldvakkienkqknryiniiaydksrvqlpllendphsdyvnanfidGyn.kkrryiaaqgpnvasvkdfwrlvfeedigkivmltnlvegekrkaekywp

DSTSKYCNLRVTLRKTEVFADYIIRTFvmSQVGQTEERYVYQYHFTVWPDKGVPQYATAVLGLRRKITKDSLPGARPWVIHCSAGVGRTGAFLVIDAMLR
|    | .. ||... ||. .| .||.  | | . . | |.|.|.| ||| |||.|..... | |.. .     . . |.||||||||||.|. .||.| 
dkkviyGkitvtrkseevnteytvrtl..svvfgdnirevvqlhytswpdmgvpkytiplmnlirtvkqhhtnsvgaivvhcsaGvGrtGtfitldavld

QAKKQKTVDIFNYVKAIREDRPHMVQTSEQYVFIHLAVLE
||. .. .|..|... .|. | .|||. ||| ||. |.||
qaeaenaidvynfitgvrqnrikmvqvaeqyqfiydalle
0036941 (Phosphotyrosine protein) phosphatases II 4-241 5.3e-80 264.2 In-house 33-275 (297) alignment 
Range on Protein: 4-241
Range on HMM: 33-275/297.0
AAKKRVNKAKNRYANIVTYDHSRVVLeklsNDPHSDYINASYLrDYDGSPKAYIATQGNICINAGDFWRMMWQERRCVIVMLTGLIEGHKKKCHQYWP--
.|..  |. |||| .|. |||.||.|    .|..||||||||. |  . ....|||||    . .|||||.|...  |||||| |.|  ..||.||||  
vallpenleknRykdilpydhtRVkl....ddegsdYinAsyv.dgydlkrkfIatqgPlpntvedFWrmvweqnvtvIvmltelvelgrekcaqywple

-DSTSKYCNLRVTLRKTEV--FADYIIRTFVMSQVGQTEERYVYQYHFTVWPDKGVPQYATAVLGLRRKITK--DSLPGARPWVIHCSAGVGRTGAFLVI
 ... .| ...|||...||  ..||..||. .. .|  |.|.|...|.| ||| |||.... .| . ... |  . ||.  | ..||||||||.|.|...
egesltygdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfielvrkvlkllpsggpvlVHCsaGvgRsgtfiaa

DAMLRQAK---KQKTVDIFNYVKAIREDRPHMVQTSEQYVFIHLAVLE
| ||.| .   |...|||...|| .|| ||..||| |||.|.. |.||
dlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyealle
0040438 (Phosphotyrosine protein) phosphatases II 4-241 1.6e-79 262.8 In-house 37-274 (317) alignment 
Range on Protein: 4-241
Range on HMM: 37-274/317.0
AAKKRVNKAKNRYANIVTYDHSRVVLEKLSNDPHSDYINASYLrDYDGSPKAYIATQGNICINAGDFWRMMWQERRCVIVMLTGLIEGHKKKCHQYWP-D
 |.. .|| |||| .|. ||||||.|  |..|..||||||||  |    ....|||||      .|||||.|... .|||||| | |  ..||.|||| .
vaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyv.dgpnlkrkfIatqgPlpntvedFwrmvweqgvtvivmLteleelgrekcaqYwplg

STSKYCNLRVTLRKTEVFADYIIRTFVMSQVGQTEERYVYQYHFTVWPDKGVPQYATAVLGLRRKITKDSLPGARPWVIHCSAGVGRTGAFLVIDAMLRQ
.| .| ...|||...|. |....||. ..  |  |.|.|...|.| ||| |||.. . .| . ... .   ..  | ..||||||||||.|.... ||.|
etltygdftvtllseeelagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfleavrealedpggpvlVHCsaGvgRtGtfiaaylmleq

AKKQKTVDIFNYVKAIREDRPHMVQTSEQYVFIHLAVLE
 .| ..||... || .|| ||..||| |||.|.. |.||
lekeggvdveeavkelreqRpgavqtpeqyrflydalle
DSPc_SM00195 4-241 1.9e-79 262.1 In-house 20-260 (263) alignment 
Range on Protein: 4-241
Range on HMM: 20-260/263.0
AAKKRVNKAKNRYANIVTYDHSRVVLEKLSNDPHSDYINASYLRDYdGSPKAYIATQGNICINAGDFWRMMWQERRCVIVMLTGLIEGHKKKCHQYWPDS
 |.|  ||.|||| ||. |||.|| |.|  ....||||||.|.. .  ..|.||||||       |||||.|.|.  .|||||   | .|.||..|||..
eaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikga.nkkkkyIatQgPlpstvedFWrmvweekvkiivmlteeeengkekcdrywpee

---TSKYCNLRVTLRKTEVFA-DYIIRTFVMSQVGQTEERYVYQYHFTVWPDKGVPQYATAVLGLRRKITKDSLPGARPWVIHCSAGVGRTGAFLVIDAM
   .... ...|.|...|    ..|.||. ... |. |.| |.||... |||.|||. .. || | |...|..     | |.||||||||||.|..|| .
sggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkkskstssgpivVhCsaGvgRtgtfvtidii

LRQAKKQKTVDIFNYVKAIREDRPHMVQTSEQYVFIHLAVLE
|.. ...|.||||. ||..|. ||.||||.||| ||. |.||
lskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaile
PTPc_SM00194 4-241 1.9e-79 262.1 In-house 20-260 (263) alignment 
Range on Protein: 4-241
Range on HMM: 20-260/263.0
AAKKRVNKAKNRYANIVTYDHSRVVLEKLSNDPHSDYINASYLRDYdGSPKAYIATQGNICINAGDFWRMMWQERRCVIVMLTGLIEGHKKKCHQYWPDS
 |.|  ||.|||| ||. |||.|| |.|  ....||||||.|.. .  ..|.||||||       |||||.|.|.  .|||||   | .|.||..|||..
eaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikga.nkkkkyIatQgPlpstvedFWrmvweekvkiivmlteeeengkekcdrywpee

---TSKYCNLRVTLRKTEVFA-DYIIRTFVMSQVGQTEERYVYQYHFTVWPDKGVPQYATAVLGLRRKITKDSLPGARPWVIHCSAGVGRTGAFLVIDAM
   .... ...|.|...|    ..|.||. ... |. |.| |.||... |||.|||. .. || | |...|..     | |.||||||||||.|..|| .
sggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkkskstssgpivVhCsaGvgRtgtfvtidii

LRQAKKQKTVDIFNYVKAIREDRPHMVQTSEQYVFIHLAVLE
|.. ...|.||||. ||..|. ||.||||.||| ||. |.||
lskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaile
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 2-241 6.3e-79 260.4 In-house 35-274 (515) alignment 
Range on Protein: 2-241
Range on HMM: 35-274/515.0
SEAAKKRVNKAKNRYANIVTYDHSRVVLEKLSNDPHSDYINASYLRDYDGsPKAYIATQGNICINAGDFWRMMWQERRCVIVMLTGLIEGHKKKCHQYWP
   |.. .|  |||| ||. || .|| || . ..|||||.||||.. .|   |||||.||       ||||...||.   |.|.| | || | || .|||
qtvaqeeinfkknryknilPydsvrvklevindnPhsdyfnasyipsfdn.dkayiasqgPnkasvddfWrlvlqenvttiamvtklkegdkikcgkyWP

D---STSKYCNLRVTLRKTEVFADYIIRTFVMSQVGQteERYVYQYHFTVWPDKGVPQYATAVLGLRRKITKDSLPGARPWVIHCSAGVGRTGAFLVIDA
|    . |. ...| |  .|  .. |.|.. . .  .   | | |.||| |||||||. ....| | ...  |    . | .||||||||||| .. || 
dkpgdsvkfGsikvelvsleactggikrkltvlkgdd..srtvtqfhfteWPdkGvpkhtssllklikevkadhgqythpliihcsaGvGrtGvvisids

MLRQAKKQKTVDIFNYVKAIREDRPHMVQTSEQYVFIHLAVLE
.. .||. ..||.||.|. ||..||..||| ||| ||. ||||
vvahakttrmvdvfnfvtnirqkrpylvqtqeqyafiygavle
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 1-242 1e-78 259.3 In-house 32-275 (281) alignment 
Range on Protein: 1-242
Range on HMM: 32-275/281.0
PSEAAKKRVNKAKNRYANIVTYDHSRVVLEKLSNDPHSDYINASYLRDYDGsPKAYIATQGNICINAGDFWRMMWQERRCVIVMLTGLIEGHKKKCHQYW
...|.|.  |. |||| ||| ||..||.... ... ..|||||...  |.| .|.|||||| .     .||.|.|... ..|||.|  ||. | |||.||
tataskadenvlknrYsnivaYDatrvkvtpneenkntDYinanfvpgykg.ekeyiatqgPvPaslvafWqmvweqkvsaivmvtreieagklkChrYW

PDST--SKYCNLRVTLRKTEVFADYIIRTFVMsQVGQTEERYVYQYHFTVWPDKGVPQYATAVLGLRRKITKDSLPGA-RPWVIHCSAGVGRTGAFLVID
|| .   || ...|.  ..|  | || |.| . .  ..|.| | | ..| |||.|||. ....|. |....| . .    | ||||||||||||... .|
Pddnselkygdvtvkstaeeekatyierkfkl.eresgetreveqlaytaWPdhGvPattkellefrkevlkltekktkaplvihCsaGvGrtGtyialD

AMLRQAKKQ-KTVDIFNYVKAIREDRPHMVQTSEQYVFIHLAVLEA
 ........ ...|. . |. .|..|  ||||  || |...|||.|
rlvkaveaeleeldvkavvaelrkernlmvqtvvqyefvykavlda
0047943 (Phosphotyrosine protein) phosphatases II 4-241 1.1e-78 259.8 In-house 32-270 (273) alignment 
Range on Protein: 4-241
Range on HMM: 32-270/273.0
AAKKRVNKAKNRYANIVTYDHSRVVLeklsNDPHSDYINASYLrDYDGSPKAYIATQGNICINAGDFWRMMWQERRCVIVMLTGLIEGHKKKCHQYWPDS
.|..  || |||| .|. ||||||.|    .|..||||||||. |   .....|||||    . .|||||.|...  |||||| |.| ...||.||||..
vallpenkdknrykdilpydhsrvkl....gdggsdyinAsyv.dgynlkrkfiatqgPlpntvedfwrmvweqnvrviVmLtelvelgrekcaqYwple

----TSKYCNLRVTLRKTEVFADYIIRTFVMSQVGQTEERYVYQYHFTVWPDKGVPQYATAVLGLRRKITKD--SLPGARPWVIHCSAGVGRTGAFLVID
    . .| ...|||...|...||..||. .. .|  |.|.|...|.| ||| |||.. . .| . ... |   .||.  | |.||||||||||.|...|
ggelsltygkftvtllseetkddytvrtleltnlgtgesrtvthfhytgwpdhgvppslesllefielvrkalealpsngpvvVHCsaGvgRtgtfiald

AMLRQAKKQKTVDIFNYVKAIREDRPHMVQTSEQYVFIHLAVLE
 .|.| .| ..||....|| .|. ||.|||| |||.|.. |.||
llldqlekeggvdvleavkllrsqRpgmvqtpeqyrflyealle
0043336 (Phosphotyrosine protein) phosphatases II 4-241 1.8e-77 255.8 In-house 39-275 (278) alignment 
Range on Protein: 4-241
Range on HMM: 39-275/278.0
AAKKRVNKAKNRYANIVTYDHSRVVLEKLSNDPHSDYINASYLrDYDGSPKAYIATQGNICINAGDFWRMMWQERRCVIVMLTGLIEGHKKKCHQYWPDS
 |..  || |||| .|. ||||||.|. |..|..||||||||. |    |...|||||    . .|||||.|...  .|||||.| | ...||.||||..
iallpenkdknrykdilpydhsrvklsllggdldsdYinAsyv.dgynvprkfiatqgPlpetvedFwrmvwelgvttivmLtelvelgrvkcaqYwpgg

TSKYCNLRVTLRKTEVFADYIIRTFVMSQVGQTEERYVYQYHFTVWPDKGVPQYATAVLGLRRKITKDSLPGARPWVIHCSAGVGRTGAFLVIDAMLRQA
. .| ...|||.|.|...||..||. ..  |  |.|.|..||.. ||| |||   . .| . ... .   .   | ..||||||||||.|.... .|.|.
sltygdftvtllkeehlddytvrtlevtnlgdgesrtvthyhylgwpdhgvpeslsllldflkavrealedsngpvlVHCsaGvgRTGtfialyllleql

KKQKTVDIFNYVKAIREDRPHMVQTSEQYVFIHLAVLE
.| ..||... || .|| ||..||| .||.|.. |.||
ekeggvdleeavkelreqRpgavqtpsqyrflyealle
0039614 (Phosphotyrosine protein) phosphatases II 4-241 6.8e-77 254.1 In-house 50-287 (297) alignment 
Range on Protein: 4-241
Range on HMM: 50-287/297.0
AAKKRVNKAKNRYANIVTYDHSRVVLEKLSN-DPHSDYINASYLRDYDGSPKAYIATQGNICINAGDFWRMMWQERRCVIVMLTGLIEGHKkKCHQYWPD
 |.. .|| |||| .|. ||||||.|  . . |..||||||||.  ||  ....|||||    . .|||||.|...  |||||| |.|  . ||.||||.
iallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfIatqgPlpetvedFwrmvweqgvtvivmLtklvelgr.kcaqywpe

STSKYCNLRVTLRKTEVFADYIIRTFVMSQvgQTEERYVYQYHFTVWPDKGVPQYATAVLGLRRKITK--DSLPGARPWVIHCSAGVGRTGAFLVIDAML
....| ...|||.|.|. ..|..||. ..     |.|.|.....| ||| |||.... .| . ... .   .||. .| ..||||||||||.|.... ||
eggtygdftvtllkvehldgytvrtlevtn..ngesrtvthfqytgwpdhgvppslellleflelvrealaelpkggpvlVHCsaGvgRtGtfiaaylml

RQAKKQKTVDIFNYVKAIREDRPHMVQTSEQYVFIHLAVLE
.| .| ..||... || .|| ||..||| .||.|.. |.||
eqlekeggvdvleavkelreqRpgavqtpsqyrflydalle
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 3-241 7.6e-77 253.2 In-house 37-275 (315) alignment 
Range on Protein: 3-241
Range on HMM: 37-275/315.0
EAAKKRVNKAKNRYANIVTYDHSRVVLEKLSNDPHSDYINASYLRDYDGsPKAYIATQGNICINAGDFWRMMWQERRCVIVMLTGLIEGHKKKCHQYWPD
 .|....|  |||| ||. .|..||.|| . ..|.||||||||.. .|   |||||.||       |||||..||.   |||.| . || | || |||||
rvaretinfkknryknilPldsarvkleviddsPdsdyinasyiksvdd.dkayiasqgPlkasvddfwrmvlqekvttivmvtkkqegdkikcrqywPd

---STSKYCNLRVTLRKTEVFADYIIRTFVMSQvgQTEERYVYQYHFTVWPDKGVPQYATAVLGLRRKITKDSLPGARPWVIHCSAGVGRTGAFLVIDAM
    . .. ...|.| ..|  .| ..| .|. .    | | | |..|| ||||||.. ....| | ...  |  .   . ..|||||||||| .. || .
rkadsvefGsikvellsleadtdgvarklvtrk..seesrtvtqfqftewPdkGvdkqtssllklikevkadngkkefsllvhcsaGvGrtGvvisidev

LRQAKKQKTVDIFNYVKAIREDRPHMVQTSEQYVFIHLAVLE
. |.|....||.||.|| .|..||..||| |.| ||. ||||
vaqikrtrsvdvfnfvknlrakrpylvqteeeyafiydavle
Y_phosphatase Protein-tyrosine phosphatase 10-241 2e-76 251.9 Pfam-A 1-235 (235) alignment 
Range on Protein: 10-241
Range on HMM: 1-235/235.0
NKAKNRYANIVTYDHSRVVLeklSNDPH-SDYINASYLRDYDgSPKAYIATQGNICINAGDFWRMMWQERRCVIVMLTGLIEGHKKKCHQYWP---DSTS
|| |||| .|. ||..|| |   ..... ||||||.|.. |. ..|..||||| .    .|||||.|||.  |||||| | | ...||.||||   . . 
nkkknRykdilpydktrvkl...kgsegpsdYInAnyvkgyk.ekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeesl

KYCNLRVTLR-KTE-VFADYIIRTFVMSQVGQT-EERYVYQYHFTVWPDKGVPQYATAVLGLRRKITKDSLPGARPWVIHCSAGVGRTGAFLVIDAMLRQ
.| ...|.|. |..   ..|..|.. ... ..  |.| |.|.|.| |||.|||. ....| | ||. |.. .   | |.|||||||||| |...|..|.|
tygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleq

AKKQKTVDIFNYVKAIREDRPHMVQTSEQYVFIHLAVLE
......||....|| .|. ||.|||. |||.|.. |.||
leaeeevdvlqivkelRkqRpgmvqsleqYiflykaile
Y_phosphatase Protein-tyrosine phosphatase 10-241 2e-76 251.9 In-house 1-235 (235) alignment 
Range on Protein: 10-241
Range on HMM: 1-235/235.0
NKAKNRYANIVTYDHSRVVLeklSNDPH-SDYINASYLRDYDgSPKAYIATQGNICINAGDFWRMMWQERRCVIVMLTGLIEGHKKKCHQYWP---DSTS
|| |||| .|. ||..|| |   ..... ||||||.|.. |. ..|..||||| .    .|||||.|||.  |||||| | | ...||.||||   . . 
nkkknRykdilpydktrvkl...kgsegpsdYInAnyvkgyk.ekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeesl

KYCNLRVTLR-KTE-VFADYIIRTFVMSQVGQT-EERYVYQYHFTVWPDKGVPQYATAVLGLRRKITKDSLPGARPWVIHCSAGVGRTGAFLVIDAMLRQ
.| ...|.|. |..   ..|..|.. ... ..  |.| |.|.|.| |||.|||. ....| | ||. |.. .   | |.|||||||||| |...|..|.|
tygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleq

AKKQKTVDIFNYVKAIREDRPHMVQTSEQYVFIHLAVLE
......||....|| .|. ||.|||. |||.|.. |.||
leaeeevdvlqivkelRkqRpgmvqsleqYiflykaile
subfamily_PTPN6_pd Subfamily PTPN6 4-239 2.9e-76 251.4 In-house 48-293 (306) alignment 
Range on Protein: 4-239
Range on HMM: 48-293/306.0
AAKKRVNKAKNRYANIVTYDHSRVVLEkLSNDPHSDYINASYLR-DYDGSPKAYIATQGNICINAGDFWRMMWQERRCVIVMLTGLIEGHKKKCHQYWPD
 ..|  || |||| ||. .||.||.|.  .. | ||||||.|.. .  || |.|||||| .     |||||.|||   ||||.|  .|  |.|| .||||
egakpenkeknryknilPfDhtrvilk.epsvpgsdyinanyikkevkgsdksyiatqgclettvsdFWrmvwqensrvivmttkevErgkekCarYWPd

STS--KYCNLRVTLRKTEVFADYIIRTFVMSQ-VGQTEERYVYQYHFTVWPDKGVPQYATAVLGLRRKITKDS--LP--GARPWVIHCSAGVGRTGAFLV
...  .| ...||  . .  ||||.|....|.   ..|||.|.||||..|||.|||.   ||| . ..... .  |    |.| |.|||||.||||.|.|
eeekeeyGkisvtnvseksladYilRelsvskkkkkkeerevfqyhfksWPdhgvpkdpgavLdfledvnrkqeeleeaeagpivvhCsaGiGRtGtfiv

IDAMLRQAKKQK---TVDIFNYVKAIREDRPHMVQTSEQYVFIHLAV
||..|.. .|..    .|| . || .|| |  .||| .|| |.. |.
iDillkliekkgldadidiqklvksvreqrsglvqteqqykfvykai
0045450 (Phosphotyrosine protein) phosphatases II 3-241 1.3e-74 247.1 In-house 48-302 (307) alignment 
Range on Protein: 3-241
Range on HMM: 48-302/307.0
EAAKKRVNKAKNRYANIVTYDHSRVVLEKLSND-PHSDYINASYLRDYDG-------SPKAYIATQGNICINAGDFWRMMWQERRCVIVMLTGLIEGHKK
..|.. .|| |||| .|. |||.||.|  |... ..|||||||| |. ..       .....|||||    .  |||||.|...  ||||||.|.|  ..
siallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydlkrkfIatqgPlpetvedFwrmlweqgvtvivmltelvelgre

KCHQYWPDS--TSKYCNLRVTLRKTEVFADYIIRTFVMSQV-GQTEERYVYQYHFTVWPDKGVPQYATAVLGLRRKITK--DSLPGARPWVIHCSAGVGR
||.|||||.  .  | |..|||...|. ..|..||. ..   |  |.|.|...|.| ||| |||..   .| . ... |  ..||.  | ..||||||||
kcaqywPdegeeltygnftvtllseehldgytvrtlevtdldgtgesrtvthfhytgwpdhgvppsfeelldfieevrkaleelpkggpvlVHCsaGvgR

TGAFLVIDAMLRQAKKQKT---VDIFNYVKAIREDRPHMVQTSEQYVFIHLAVLE
||.|.... |||| .|..|   ||... || .|| ||..||. |||.|.. |.||
tGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyealle
subfamily_PTPN12_pd Subfamily PTPN12 2-241 3.9e-74 244.1 In-house 32-275 (290) alignment 
Range on Protein: 2-241
Range on HMM: 32-275/290.0
SEAAKKRVNKAKNRYANIVTYDHSRVVLEKLSNDPHSDYINASYLRDYDGsPKAYIATQGNICINAGDFWRMMWQERRCVIVMLTGLIEGHKKKCHQYWP
.||..| .|..|||| .|. ||.|||.|.| .....||||||....  .| ...|||.|| .     |||||.|. .  ..||.  ..|  ||||..|||
teagekeenvkknrykDilPydksrvelskieeeegsdYinanfikgveg.kleyiaaqgPLpktlddfWrmiweknveivvmaCrevelgkkkCerYWp

DSTSK---YCNLRVTLRKTEVFA-DYIIRTFVMSQvgQTEERYVYQYHFTVWPDKGVPQYATAVLGLRRKITKDSLPGARPWVIHCSAGVGRTGAFLVID
... .   . ...||| . . .  |..|||. . .  | |.| |||.|.| |||.|||. |. .| | ... .     . | |.||||||||||. ..||
eegeeelefgefevtleeekavdddflirtLkvea..qkesrkvyqfhYtaWPDhgvPssaksllelielvrelqesedaPlvvhCsaGvGrtGtiiaid

AM---LRQAKKQKTVDIFNYVKAIREDRPHMVQTSEQYVFIHLAVLE
 .   |.. | ....|.|. |  .|..|. .||| |||.... ||.|
yvrellkaekipeeldvfdlvlelrkqraalvqtkeqyelvykavae
0042113 (Phosphotyrosine protein) phosphatases II 5-241 1e-72 239.8 In-house 4-241 (245) alignment 
Range on Protein: 5-241
Range on HMM: 4-241/245.0
AKKRVNKAKNRYANIVTYDHSRVVLEKLSNDPHSDYINASYLrDYDGSPKAYIATQGNICINAGDFWRMMWQERRCVIVMLTGLIEGHKKKCHQYWP-DS
|.. .|| |||| .|. |||.||.|   ..|..||||||||  | .  .. .|||||    . .|||||.|...  .||||| . | ...||.|||| ..
allpenkdknrysdilpydhtrvklspdggdldsdyinasyv.dgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywplge

TSKYCNLRVTLRKTEVFADYIIRTFVMSQVGQTEERYVYQYHFTVWPDKGVPQYATAVLGLRRKITKDSL-PGARPWVIHCSAGVGRTGAFLVIDAMLRQ
. .| ...|||...|...||..||. .. .|  |.| |..||.. ||| ||| .   .| . . . |    ..  | ..||||||||||.|.... ||.|
sltygdftvtllseehlddytvrtlevtnlgddesrevihyhylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylmleq

AKKQKTVDIFNYVKAIREDRPHMVQTSEQYVFIHLAVLE
..| ..|.... || .|. ||..||| .||.|.. |.||
lekelgvsleeavkelrsqRpgavqtpsqyrflyealle
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 4-242 1.2e-72 239.6 In-house 45-283 (297) alignment 
Range on Protein: 4-242
Range on HMM: 45-283/297.0
AAKKRVNKAKNRYANIVTYDHSRVVLEKLSNDPHSDYINASYLRDYDGspkAYIATQGNICINAGDFWRMMWQERRCVIVMLTGLIEGHKkKCHQYWPDS
 |.|.||  |.||.||. || ||| |. . .|| |||.|||... .      .|.||        |||.|...|.  .||||. . |..| || .||.|.
vaekkvnfeksRYkniLPydssRvkLaivnddpdsDyvnasfvkgnkh...rlittqmPmkatvadfWamvldeqvstivmlnddnerdk.kcaryWsdk

TS-KYCNLRVTLRKTEVFADYIIRTFVMSQVGQTEERYVYQYHFTVWPDKGVPQ--YATAVLGLRRKITKDSLPGAR-PWVIHCSAGVGRTGAFLVIDAM
.. .. .. |.|  ..    .| |......     .| | ||.|. |||| |..   |...| |   . ||    |  | ..||.||||||| .| || .
gvttfGdvsvvllsvsereGfikrelevtkgkakarrvvkqyqfveWPdkaverkdsassllklisevrkdfsqnaegPllvhclaGvGrtgvlltidsv

LRQAKKQKTVDIFNYVKAIREDRPHMVQTSEQYVFIHLAVLEA
. .||..|.||||..|| .|..||..||| ||| |.. |||||
vaeakrekevdifglvkklrqerpylvqtkeqykfvyvavlea
0040439 (Phosphotyrosine protein) phosphatases II 4-241 1.6e-72 239.4 In-house 5-244 (249) alignment 
Range on Protein: 4-241
Range on HMM: 5-244/249.0
AAKKRVNKAKNRYANIVTYDHSRVVLEKLSNDPHSDYINASYLrDYDGSPKAYIATQGNICINAGDFWRMMWQERRCVIVMLTGLIEGHKKKCHQYWP-D
 |.. .|| |||| .|. ||||||.|. |.. ..||||||||. |.  .....|||||      .|||||.|...  |||||| | |  ..||.|||| .
vallpenkdknrypdilpydhsrvklsilpglflsdyinAsyi.dgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywplg

STSKYCNLRVTLRKTEVFADYIIRTFVMSQVGQTEERYVYQYHFTVWPDKGVPQYATAVLGLRRKITK--DSLPGARPWVIHCSAGVGRTGAFLVIDAML
.. .| ...|||...||..||..||. .. ..  |.|.|.....| ||| |||..   .| . ... |  ..||   | ..||||||||||.|.... ||
gsleygdftvtllsvevkddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaaylml

RQAKKQKTVDIFNYVKAIREDRPHMVQTSEQYVFIHLAVLE
.| .| ..||....|| .|. ||..||. |||.|.. |.||
eqlekelgvdleeavkllrsqRpgavqnpeqyrflyealle
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 9-241 3e-72 238.6 In-house 60-289 (319) alignment 
Range on Protein: 9-241
Range on HMM: 60-289/319.0
VNKAKNRYANIVTYDHSRVVLEKLSNDPHSDYINASYLRDYDgSPKAYIATQGNICINAGDFWRMMWQERRCVIVMLTglieghKKKCHQYWPDS-TSKY
 || |||. ||...|...| ||.|     |||||||..  |  ... |||.||       |||||.|. . . ||.||      |.|| ||||     |.
qnkdknriinilafdknvvklerliGeefsdyinasfvtGyq.rkdkyiaaqGPldntladfWrmiweyncstivllt......kdkcsqywplkivike

CNLRVTLRKTEVFADYIIRTFVMSQ-VGQTEERYVYQYHFTVWPDKGVPQYATAVLGLRRKI--TKDSLPGARPWVIHCSAGVGRTGAFLVIDAMLRQAK
 .  | .   |  |.|..| . .|.   ... | . |.||  |||.|||.|.. .. | .|.   ..   . .. |.||||||||||...|.|..| . |
erfkvkvdsveetaeyvvrdielsedgkekdirkitqfhflGwpdvGvpdypsdlmrlvkkvrhltskenhranivvhcsaGvGrtGvyivldvlldrmk

KQKTVDIFNYVKAIREDRPHMVQTSEQYVFIHLAVLE
..| ||..|.|. .|..|...||   || ||. |.||
eekqvdvynfvrdlrqqrntlvqdlvqykfiysalle
subfamily_Ptp69D_pd Subfamily Ptp69D 3-241 6e-72 237.4 In-house 41-284 (307) alignment 
Range on Protein: 3-241
Range on HMM: 41-284/307.0
EAAKKRVNKAKNRYANIVTYDHSRVVLEKLSNDPHSDYINASYLRDYDGSpKAYIATQGNICINAGDFWRMMWQERRCVIVMLTGLIEGHKKKCHQYWP-
....|  |. |||| .|...|. ||.|.|.  . .|||||||... |. . | .|| |. .   .||||||...    .||||. | |  .|||..||| 
kvsekkenalknRyedikafDktRvkLkkingkedsdYinasfikgykek.kkfiaaqdPveatigDfWRmiaeqevtlivmlsnlteknrkkcakYWpi

DSTSKYCNLRVTLRKTEVFADYIIRTFVMSQVG-----QTEERYVYQYHFTVWPDKGVPQYATAVLGLRRKITKDSLPGARPWVIHCSAGVGRTGAFLVI
. . .| .. |.| ..|   |||||.. .|...       ..| | |||.| |.|  ||. |...| | ... .       | |.||||||||.| |. .
edevqygdilvklvseekhsdyiiReldvskkkeesgevedsrkvvqyhytgWkDskvPevargllklieqvrelyklnrsPivvhCsaGvgrsgifval

DAMLRQAKKQKTVDIFNYVKAIREDRPHMVQTSEQYVFIHLAVLE
| .| | |. ..||||. || .|..|. .||  |||||.. |.|.
dsllqqlkaedkvdifetvkdLrsqRnllvqsleqYvflyralld
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 9-241 2e-71 235.8 In-house 24-253 (284) alignment 
Range on Protein: 9-241
Range on HMM: 24-253/284.0
VNKAKNRYANIVTYDHSRVVLEKLSNDPHSDYINASYLRDYDgSPKAYIATQGNICINAGDFWRMMWQERRCVIVMLTglieghKKKCHQYWPDS-TSKY
 || |||. .|...|...| ||.|     |||||||..  |  ... ||||||       |||||.|. . . ||.||      |.|| ||||     |.
qnkdknrighilafdknvvklerliGeefsdyinasfitGyq.rkdkyiatqGPldntladfWrmiweyncstivllt......kdkcsqywplkivike

CNLRVTLRKTEVFADYIIRTFVMSQV-GQTEERYVYQYHFTVWPDKGVPQYATAVLGLRRKI--TKDSLPGARPWVIHCSAGVGRTGAFLVIDAMLRQAK
 . .| .   |  ..|..| . .|.   ... | . |.||  |||.|||.|.. .. | .|.   ..   . .. |.||||||||||...|.|..| . |
erfkvkvdsveeseeyvvrdielsedgkekdirkirqfhflgwpdvgvpdypsdlmrlvkkvrhltskenhranivvhcsagvgrtgvyivldvlldrmk

KQKTVDIFNYVKAIREDRPHMVQTSEQYVFIHLAVLE
..| ||..|.|. .|..|...||   || ||. |.||
eekqvdvynfvrdlrqqrntlvqdlvqykfiysalle
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 4-242 3.8e-71 234.9 In-house 42-287 (325) alignment 
Range on Protein: 4-242
Range on HMM: 42-287/325.0
AAKKRVNKAKNRYANIVTYDHSRVVLEKLSNDPHSDYINASYLRDYDGSpKAYIATQGNICINAGDFWRMM--WQerrCVIVMLTGLIEGHKKKCHQYWP
.| |  ||||||. |.|..|.|||||| . .||.|||||||||||. .  . ..|.|       .|.||..  |.   | .|...  ... |..| .|||
vamkpenkaknrfknvvaldksrvvletkkddpssdyinasylrddkkk.dvflaaqaPltatindlWrlvldWr...csvvvvlneldlgkdrcavywp

DS---TSKYCNLRVTLRKTEVFADYIIRTFVMSQVGQTEERYVYQYHFTVWPDKGVPQYATAVLGLRRKITKD------SLPGARPWVIHCSAGVGRTGA
.    . ..  |.| ||  | ..||. | . . || . | | | |...  |.| ||... .... . . . .          .. | ..||||||||||.
kemgksktfGglevklrtieeisdyvhrvldvkqvkkGetrsvkqfqlqswddmGvqkrpatlisilqlvkavservtantkastpilvhcsaGvGrtGv

FLVIDAMLRQAKKQKTVDIFNYVKAIREDRPHMVQTSEQYVFIHLAVLEA
|. . ..| .  ..  ||||..|| .|.||| ||.| .||..|. |. ||
fislysalakvieesrvdifgfvkklrkdrpsmvetvdqyiliyealvea
subfamily_PTPN9_pd Subfamily PTPN9 4-241 6.3e-71 233.8 In-house 36-288 (297) alignment 
Range on Protein: 4-241
Range on HMM: 36-288/297.0
AAKKRVNKAKNRYANIVTYDHSRVVLEKLSNDPHSDYINASYLRDYDgSPKAYIATQGNICINAGDFWRMMWQERRCVIVMLTGLIEGHKKKCHQYWP--
|.|.|.|  ||||.... ||..||||.|...|..||||||...  |   .||.||||| .     |||||.|...  |||| | ..|  . || ||||  
asklranleknrytdvlcydetrvvlakvdedeasdyinanfvdGyk.qkkafiatqGplkktvsdfWrmvWeqevlvivmttrvvergrlkcgqyWple

-DSTSKYCNLRVTLRKTEVFADYIIRTFVMSQVGQTEERYVYQYHFTVWPDKGVPQYATAVLGLRRKITK-------------DSLPGARPWVIHCSAGV
 .|.... .|.|.  ..|.  || .|......| . |.| |  . |. ||| |||. |...| ...|. .                |   | |.|||||.
eessaefgdlsvsnveveeeedykvrvleiknvkteesrkvthfqflsWPdyGvPssaaslldvlekvrekqalavkelgdewkghpsgPPivvhcsaGi

GRTGAFLVIDAMLRQAKKQKTVDIFNYVKAIREDRPHMVQTSEQYVFIHLAVLE
||||.|  .|  | . ... |||... || .|. | ...|| |||.| .|||||
GrtGtfitldiclsrleevgtvdvvetvkllrtqrafsiqtpeqyefcylavle
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 10-239 8.4e-71 233.2 In-house 28-264 (274) alignment 
Range on Protein: 10-239
Range on HMM: 28-264/274.0
NKAKNRYANIVTYDHSRVVL-EKLSNDPHSDYINASYLRDYDGSPKAYIATQGNICINAGDFWRMMWQERRCVIVMLTGLIEGHKKKCHQYWPDSTS---
.. |||| .|.  ..|||.| .. |.|. |.|||| |.. ||.  |||.|||| .     |||||..||.  |||||| | | ...||..|.||...   
sqtknryktilPnensrvllesessededssyinanyikGydeeskayvatqGPlpntvadfWrmiyqeevqvivmltklkeaneqkCavyfPdaedyei

--KYCNLRVTLRKTEVFADYIIRTFVMSQVGQteERYVYQYHFTVWPDKGVPQYATAVLGLRRKITKDSLPG-A--RPWVIHCSAGVGRTGAFLVIDAML
  .| .. .. .|.    || .|..|.... .  || |. | .| |||. .|. |...| | ... ..     |   | |.|||||.||||.|. |.  .
serygdveikvekiverndysvrklvlkyler..ersvkhywytdWPdhksPddantlldlvleveesreeenaklapvvvhCsaGiGrtGcfiaisiav

RQAKKQKTVDIFNYVKAIREDRPHMVQTSEQYVFIHLAV
|| .....||... |  .| ||  |||||||| .|| |.
rqlreeivvdvlkivcnlrldrGGmvqtseqyelihral
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 8-241 4.8e-70 230.7 In-house 44-281 (290) alignment 
Range on Protein: 8-241
Range on HMM: 44-281/290.0
RVNKAKNRYANIVTYDHSRVVLEKLSNDP--HSDYINASYLRDYDGSpKAYIATQGNICINAGDFWRMMWQERRCVIVMLTGLIEGHKKKCHQYWPDS-T
  || .||.|||| ||  |..| ..|...    .||||.|. .|  . |.|||||| .   . |||...|||. ..|||||  || .|.||.|||||| |
ssnkllnRfanivvyddnritLrpisghkDCtneyinAcyikgykek.kqyiatqgpvsntlvdFWkliwqekvtiivmltniieegkvkCqqYWpdsdt

SKYCNLRVTLRKTEVFADYIIRTFVMSQVGQ-TEERYVYQYHFTVWPDKG-VPQYATAVLGLRRKITKDSLPGARPWVIHCSAGVGRTGAFLVIDAMLRQ
..| . ...| . |.. .||.|.. . .  .  ... | ||..| |...| |....| .| ... . .   .| .. |.|||..|||.. |....  . .
kaygefsikllneetlneyierklevknknsagakqsvtqyqitnwdstgkvtnpqtillvieemyktqrkrgntsivvHCSdtvgrsavfcaaattink

AKKQKTVDIFNYVKAIREDRPHMVQTSEQYVFIHLAVLE
.|..  .|.|. .|  |  .| .||| .|| .|.  ||.
cktegvidvfqvlksqRiqkpgsvqtvqqyqgifqivlt
0037934 (Phosphotyrosine protein) phosphatases II 4-241 5.8e-70 230.9 In-house 4-240 (243) alignment 
Range on Protein: 4-241
Range on HMM: 4-240/243.0
AAKKRVNKAKNRYANIVTYDHSRVVLeklsnDPhSDYINASYLRDYdgsPKaYIATQGNICINAGD----FWRMMWQERRCVIVMLTGLIEGHKKKCHQY
 |.. .|. |||| .|..||||||.|     .. ||||||.. . .   |. .|||||    .  |    ||||.|...  |||||| |.|  ..||.||
iallpenlsknrysdilpydhsrvkl.....eg.sdyinanliyvt...pr.liatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqy

WPDSTsKYCNLRVTLRKTEVFADYIIRTFVMSQVG-QTEERYVYQYHFTVWPDKGVPQYATAVLGLRRKITKD--------SLPGARPWVIHCSAGVGRT
||...  | ...||| ..|...||..||.... .. . ..|.|..||.. ||| |||.  . .| . .....          |.. .| ..|||||||||
wpgev.tygdftvtllseehlddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRt

GAFLVIDAMLRQAkkqkTVDIFNYVKAIREDRPH-MVQTSEQYVFIHLAVLE
|...... ||..     .||....|| .|| ||. .||| .||.|.. |.||
Gtliaaylmllll....gvdleeavkllreqRpgkavqtpsqyrflyealle
0045098 (Phosphotyrosine protein) phosphatases II 6-241 2.4e-69 229.1 In-house 29-270 (278) alignment 
Range on Protein: 6-241
Range on HMM: 29-270/278.0
KKRVNKAKNRYANIVTYDHSRVVleklsndphsDYINASYLRDYdgsPKAYIATQGNICINAGDFWRMMWQERRCVIVMLTGLIEGHKKKCHQYWPDST-
 .. |..|||| .|. ||||||.          |||||||.. |   ||..|||||    .. |||||.|...  ||||||.|.|. ..||.||||..  
lylgnldknRykdilpydhsrVk..........dYINAsyidgy...pkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrekcaqywpeggs

SKYCNLRVTLRKTEVFADYIIRTFVMSQV----GQTEERYVYQYHFTVWPDKGVPQYA--TAVLGLRRKITKDSL-------------PGARPWVIHCSA
  | ...||| ..||. ||..||. .  .       |.|.|...|.. ||| ||| .   . .| | . | .                ..  | ..||||
ltygdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsggpvlVHCsa

GVGRTGAFLVIDAMLRQAkkQKTVDIFNYVKAIREDRPH-MVQTSEQYVFIHLAVLE
||||||.. ... ||..   ...||....|| .|. ||. .||. |||.|.. ..||
GvgRtGtlvaaylmlell..eggvdlleavkelrsqRpglavqnleqyrflyeflle
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 9-241 5.9e-67 220.6 In-house 46-276 (287) alignment 
Range on Protein: 9-241
Range on HMM: 46-276/287.0
VNKAKNRYANIVTYDHSRVVLEklsnDPHSDYINASYLRDYDgSPKAYIATQGNICINAGDFWRMMWQERRCVIVMLTGLIEGHKKKCHQYWPDST-SKY
 || |||...|. .|  ||.|.    . | |||||...  |  . ||.|.... ..  | .||.......  .||||. . | ....|.||||...   .
qnkdknRltqilvpdnyrvllk....gehpdyinavfidgyk.ekkafiiaesPmfntarnfWkliddrnvtaivmlcqekendeevcyqyWpeeksvvl

CNLRVTLRKTEVFADYIIRTFVMSQVGQ-TEERYVYQYHFTVWPDKG-VPQYATAVLGLRRKITKDSLPGARPWVIHCSAGVGRTGAFLVIDAMLRQAKK
 . ...| . || |.||.|.. . . .. .... | ||..| |...| |....| .| . ... ..  .|  . |.|||..|||.. |. ..  ....|.
GeyniellneevnagyierklevknknkagdkqqvkqyqitnWdstgkvtepqtillvieemyktqrkrgntsivvhCsdtvGrsamfcaaattinkckt

QKTVDIFNYVKAIREDRPHMVQTSEQYVFIHLAVLE
. ..|.|. .|  |  .|..||| ||| ||  .|||
eGviDvfqvlksqriqkpgsvqtveqykfindivle
subfamily_PTPN3_pd Subfamily PTPN3 4-241 1.3e-64 212.8 In-house 35-273 (280) alignment 
Range on Protein: 4-241
Range on HMM: 35-273/280.0
AAKKRVNKAKNRYANIVTYDHSRVVLEKLSNdphsDYINASYLR-DYDGSP--KAYIATQGNICINAGDFWRMMWQERRCVIVMLTGLIEGHKKKCHQYW
||.|  | .|||| .|..||. || |.. ..    |||||.|.  . ...   . |||||| .   | |||.|.|...  .||||| |.|  ..||||||
aarkpenlsknryrdilpydatrvklkeset....dyinanyvnmeipstglvnryiatqGPlaktatdfWqmvweqksslivmlttlverGrvkChqyW

PDS--TSKYCNLRVTLRKTEVFADYIIRTFVMSQVGQTEERYVYQYHFTVWPDKGVPQYATAVLGLRRKITKDSLPGARPWVIHCSAGVGRTGAFLVIDA
|..  ...| ...|...|..    |..| .|...  ..||| . |  .. |||.|||. .. .| . ... |      .| |.|||||.|||| ..... 
PetedeleygefsvkcekedetksyvlrelvlkdketkeerkilqlqylaWpdhgvPddsadflefvervrklrsgkeePvvvhCsaGigrtGvlillet

MLRQAKKQKTVDIFNYVKAIREDRPHMVQTSEQYVFIHLAVLE
 |    ... | . . |. .|. |  .|||..|| |.  |.|.
alalieaaepvypldivrtmrdqramlvqtasqykfvCeailk
subfamily_PTPRN_pd Subfamily PTPRN 3-241 4.4e-64 211.0 In-house 49-290 (297) alignment 
Range on Protein: 3-241
Range on HMM: 49-290/297.0
EAAKKRVNKAKNRYANIVTYDHSRVVLEKLSNDPHSDYINASYLRDYDGSPKAYIATQGNICINAGDFWRMMWQERRCVIVMLTGLIEGHKKKCHQYWPD
|.||.  |  |||......|||||| |.. ... .||||||| . | |    ||||||| .  .  |||.|.|..  .|||.|| | |   |.|..||||
evakaeknvkknrskavlpydhsrvklkeeasaeksdyinasaildhdprapayiatqgplastvadfwqmvweqGvvvivnltrleeegvkqckrywpd

STSK-YCNLRVTLRKTEVFA-DYIIRTFVMSQVGQTEERYVYQYHFTVWPDKGVPQYATAVLGLRRKITKDSLPGARPWVIHCSAGVGRTGAFLVIDAML
  |. |    | |    ... ||..|.| . .. ..| | | |.||  ||..|||  | ..| .|||. |     . | |.|||.|.||||....|| .|
eGsevyhiyevhlvsehiwcddylvrsfylknlqtsetrtvtqfhflswpeegvPasaksllefrrkvnksyrGrscpivvhcsdGaGrtGvyilidlvl

RQ-AKKQKTVDIFNYVKAIREDRPHMVQTSEQYVFIHLAVLE
 . .|  | .||   .. .|..||..|.| .|. |.  || |
nrllkGvkeidiaatlehlrdqrpglvktkdqfefaltavae
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 2-241 9e-63 207.0 In-house 37-234 (392) alignment 
Range on Protein: 2-241
Range on HMM: 37-234/392.0
SEAAKKRVNKAKNRYANIVTYDHSRVVLEKLSNDPHSDYINASYLRDYDGSpKAYIATQGNICINAGDFWRMMWQERRCVIVMLTGLIEGHkkkchqywp
  .|.| .|. |||| ||. || .||.|| . . |.|||.||||.. .|   |||||.||       |||||..||. . |.|.| | ||          
qtvaqkeinlkknryknilpydsarvkleviddipdsdylnasyipsfdne.kayiasqgpnaaslddfwrmvfqenvttiamvtklkegd.........

dstskycnlrvtlrktevfadyiirtfvmsqvGQTEERYVYQYHFTVWPDKGVPQYATAVLGLRRKITKDSLPGARPWVIHCSAGVGRTGAFLVIDAMLR
                                   . | | |.||| ||||.||......| . ...  |    ..| .|||||||||||  . ||... 
................................kgddartvaqfhftewPdkdvpkhtssllkfikevkadfGqythpliihcsagvgrtgvvisidsvva

QAKKQKTVDIFNYVKAIREDRPHMVQTSEQYVFIHLAVLE
.||| . ||.||.|  ||. ||.|||| ||| ||. ||||
hakktrmvdvfnfvtnirrkrpymvqtkeqyafiygavle
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 9-240 3.4e-61 201.6 In-house 19-261 (270) alignment 
Range on Protein: 9-240
Range on HMM: 19-261/270.0
VNKAKNRYANIVTYDHSRVVLEKLSNDPHSDYINASYLRDYDGSPKAYIATQGNICINAGDFWRMMWQERRCVIVMLTGLIEGHKKKCHQYWPDSTSK--
 .|. ||||.|.   ..||.||.|..|... |||| |.| .||..|.|||..|       .||||.|.|.   |||.||| |  .||| .||| .. .  
rgkklnRyadiLPsPatRvrleeleedsataYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkgrkkCerYWpaepkekv

---YCNLRVTLRKTEVFADYIIRTFVMSQVGqtEERYVYQYHFTVWPDKGVPQYAT------AVLGLRRKI--TKDSLPGARPWVIHCSAGVGRTGAFLV
   . ...|.  ..|    ||..   . . |  ||| .  .... |||.|||. .        .| . |..  ....|  | |...|||||||||| ...
kledgkikvlalseekeegyiltrlrleekg..eerrlvHfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkaePllvHcsaGvgRtGtlia

IDAMLRQAKKQKTVDIFNYVKAIREDRPHMVQTSEQYVFIHLAVL
.| ..|  ...| ||. . ....|.||. .||..||| |.. ||.
lDiavrlLeetkkvdvlaiieelRkdRmalvqhpeqyeflykavv
subfamily_PTPN13_pd Subfamily PTPN13 3-241 4.4e-60 198.3 In-house 30-267 (273) alignment 
Range on Protein: 3-241
Range on HMM: 30-267/273.0
EAAKKRVNKAKNRYANIVTYDHSRVVLEKLSNdphsdYINASYLRDYDG-SPKAYIATQGNICINAGDFWRMMWQERRCVIVMLTGLIEGHKKKCHQYWP
| .||. ||.|||| |.. ||..|| |.. ..     |||||...   |     |||.|| .   . |||.|.|. .  ||.|.|   |. | |||.|||
evgkkkenkdknryrnvlPydetrvklgdegg.....yinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweqkaeviamvtlekekgkvkchrywP

DSTSKYC---N-LRVTLRKTEVFADYIIRTFVMSQVGQTEERYVYQYHFTVWPDKGVPQYATAVLGLRRKITKDSLpGARPWVIHCSAGVGRTGAFLVID
.|..|     | |.|.| |..   .. .|.. ....  .| | | . .|. ||| |||. |. .| . ... .     | | |.|||||.||.|....||
esknkklkvsnrlevellkvqkldgfvvralavkdsesgesrevahlnfvkwPdhgvPssaaellqfvaevrrlqt.dagPivvhcsaGiGrsGtlitid

AMLRQAKKQKTVDIFNYVKAIREDRPHMVQTSEQYVFIHLAVLE
..|   ...| .|. . |. .|| |  .|||..||.|.. |.||
vvlglierdkefdvkeivrklreqrqgvvqtkdqyifvykaile
subfamily_PTPN1_pd Subfamily PTPN1 3-241 3.5e-57 188.3 In-house 25-269 (290) alignment 
Range on Protein: 3-241
Range on HMM: 25-269/290.0
EAAKKRVNKAKNRYANIVTYDHSRVVLEKLSNdphsDYINASYLrDYDGSPKAYIATQGNICINAGDFWRMMWQERRCVIVMLTGLIEGHKKKCHQYWPD
..||.  |...||| ..  |||||..||. .|    |||||| . . .   . || ||| .   .. ||.|.|...   .|||  ..| .. ||.|||| 
reaklpenrnlnryrdvspydhsrikleradn....dyinaslv.eleeakrsyiltqGPlpntvdhfWqmvWeqkskavvmlnkvvekeqikcaqywPq

STS------KYCNLRVTLRKTEVFADYIIRTFVMSQVGQTEERYVYQYHFTVWPDKGVPQYATAVLGLRRKITKD-SL-PGARPWVIHCSAGVGRTGAFL
  .      .  .|.|.| ..|.   |..|.. . ..   | | ....|.| ||| |||.  .| | .  |. .  || .   | |||||||.||.|.| 
geeekellledtklkvkliseerksyytvrllelenlktqetreilhfhyttwpdfgvpespaaflkflfkvresGslssdvGpavihcsaGiGrsGtfc

VIDAMLRQAKKQKT---VDIFNYVKAIREDRPHMVQTSEQYVFIHLAVLE
..|..| . .|..    ||| . . ..|. |  ..|| .|  | .||.||
lvdtclvliekkddlssvdikkvllelrkyrlGliqtadqlrfsylaile
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 7-241 6.9e-57 187.8 In-house 45-277 (439) alignment 
Range on Protein: 7-241
Range on HMM: 45-277/439.0
KRVNKAKNRYANIVTYDHSRVVLEKLSNDPHSDYINASYLRDYDgSPKAYIATQGNICINAGDFWRMMWQERRCVIVMLTGLIEGHKkkchqYWPDSTSK
.  ...|||| .....||.||.|...   ||| |||| |.. |   .| ||||||    .. ||||......   ||||| |.| .|     ||| ..  
qeydqtknrykdvgafdhtrvtlqeipgvphshyinanyikGyy.ddklyiatqgpkkettddfwrlviekktvtivmltnlvesyk.....ywpsdaev

-YCNLRVTLRKTEVFADYIIRTFVM-SQVGQT-EERYVYQYHFTVWPDKGVPQYATAVLGLRRKITK-DSLPGARPWVIHCSAGVGRTGAFLVIDAMLRQ
 | .. |   .   . .|.|| | .  .  .|  || | |.|.. |||| ||  |. || . | |   .      | |.||||||||||. . .|  | |
cygdiavrvdrnielpnyvirgfkvfnerdttekertvlqfhyiawpdknvpaqashvldflrainsandkeeygpvvvhcsagvGrtGtiialdialeq

AKKQKTVDIFNYVKAIREDRPHMVQTSEQYVFIHLAVLE
 | .. |||   || .|..| .|||.  |||||. ||||
lklenkvdikgivkvlrkqrkqmvqalcqyvfiynavle
subfamily_PTPN23_pd Subfamily PTPN23 6-241 2.5e-56 185.6 In-house 39-278 (288) alignment 
Range on Protein: 6-241
Range on HMM: 39-278/288.0
KKRVNKAKNRYANIVTYDHSRVVLEklsnDPHSDYINASYLRDYDGSPKAYIATQGNICINAGDFWRMMWQERRCVIVMLTGLIEGHKKKCHQYWP---D
  ...  |||. .|. |||.||.|.    . . ||||||...|       .||||. .   ..|||.|.....  |||||.   | .|.|...|||   .
iaklyseknrsrdilPyDhnRvklr....gskDDYinAsfvkdlspgcPdfiatqaPlqstlnDFWlmvyeqkssviVmllskeelgkpkvdrYwPedkg

STSKYCNLRVTLRKTEVFADYIIRTFVMSQVGQTEERYVYQYHFTVWPDKGVPQYATAVLGLRRKITK----DSLPGARPWVIHCSAGVGRTGAFLVIDA
 | |. .|.|||....    .. |.. ..  .. . . |   ..| ||. |||.    .| .  .. .       .   | |.||||||||||.| .. |
etvkfgdlsvtlksvretethvervlkletldadavksvshlqltsWpelGvPasPetllqfldevesayeavqrksktPlvvhCsaGvgRtgvfalvya

MLRQAKKQKT-VDIFNYVKAIREDRPHMVQTSEQYVFIHLAVLE
 .|. .|..  .|| . |. .||.| .|||..||. |   ||||
avrelekgnglldiiqvvsrlreqRrfmvqekeqlkfsyeavle
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 8-239 2.2e-55 182.5 In-house 38-289 (301) alignment 
Range on Protein: 8-239
Range on HMM: 38-289/301.0
RVNKAKNRYANIVTYDHSRVVLEKLSN--DPHSDYINASYLRDYDGSpKAYIATQGNICINAGDFWRMMWQERRCVIVMLTGLIEGHKKKCHQYWPDST-
  ||| ||. ||..||. |..|.. .|    . .||||||. .|  . |..||.|| .     ||||..|||.   |||.|.| || |.||.||||.|. 
eenkalnrfknitvyddnriilkpkpnldlcqreyinasyidgysek.kkfiaaqgpmkktlvdfWrliwqekpvsivmvtnlkegtkskceqywpnsea

--SKYCNLRVTLRKTEVFADYIIRTFVM-S-------------QVG-QTEERYVYQYHFTVWPDKGV-PQYATAVLGLRRKITKDSLPGARPWVIHCSAG
  ... .. ||| .. |. |..|| . .               .|  . . . | |.. | ||. || ....| .  .   | .   .|  | |.|||..
eseefgpftvtlvneqvyPdfvirqlnvkiqdgsnngyierkfkvksdksswdvlqlqvtdWpqdGvvreprtvLqviddvihrqqkigggpvvVHCSdt

VGRTGAFLVIDAMLRQAKKQKTVDIFNYVKAIREDRPHMVQTSEQYVFIHLAV
|.|.| .  ..  | |.| .  ||.|. .||.|  .| .|.| |||..|. ..
VsrsGvYcsvsiglEQckaegVVdvfqvtkavrrskpgaVtTLeqytsiydvi
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 4-241 2.3e-55 182.5 In-house 27-264 (283) alignment 
Range on Protein: 4-241
Range on HMM: 27-264/283.0
AAKKRVNKAKNRYANIVTYDHSRVVLEKLSNdphsDYINASYLR--DYDGSPKAYIATQGNICINAGDFWRMMWQERRCVIVMLTGLIEGHKKKCHQYWP
 |  . || |||. .||..|  || |. .|.    |||||...   . .   | ||..|. .     |||.|...|. . ||||| | |. ..|| ||||
iasadenkrknrnqeivpadqwrvelksesr....dyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfdekitaivmltklqedlrikCsqyWP

DS-TSKYCNLRVTLRKTEVFADYIIRTFVMSQVGQTEE-RYVYQYHFTVWPDKGVPQYATAVLGLRRKITKDSLPGARPWVIHCSAGVGRTGAFLVIDAM
   . .| .. |||||      .||. ... . . ...   .  | .  | . |      ... . . |..       | |.|||.|.|||..|. . | 
krGsedyGeftvtlrkettsnsfiikelllrvnssakstlllahyqvidWleygeqaiinslvkfnkvislqteskkgPivvhCstgiGrtavfiaasas

LRQAKKQKTVDIFNYVKAIREDRPHMVQTSEQYVFIHLAVLE
. .|. .  ||.|. || .||.|. .||| .|| ..| .|||
vkdaltesvvdvfavvkimreqrmmavqtldqyklvhelvle
subfamily_CG7180_pd Subfamily CG7180 5-240 8.4e-55 180.5 In-house 37-287 (296) alignment 
Range on Protein: 5-240
Range on HMM: 37-287/296.0
AKKRVNKAKNRYANIVTYDHSRVVLEKLSNDPHSDYINASYLRDYDgSPKAYIATQGNICINAGDFWRMMWQERRCVIVMLTGLIEGHKkKCHQYWPDS-
. .  |. |||. ..| ||. |||||||  . .||||||.|   .   .|.|| |..      ..|||....|    .|.||   . .| ....|||   
glrkenreknrdvkvvPyDynRvvLekldGeeksdYinavyvdsfl.kkkeyivteapkketvdefWrlvydeeisavvvLtktfdfak.mypsywpnks

TSKYCNLRVTLRKTEVFADYIIRTFVMSQV----------GQTEERYVYQYHFTVWPD-KGVPQYATAVLGLRRKIT--KDS---LPGARPWVIHCSAGV
  .| .. | . ... .|.  |||| . .            ..|.| | ....|.|.  . ||  ..|.. |||..   ..     |   | |...| |.
keqygeifveiveekqyanlkirtfkltkkivalteqekqvkaetRivklfqlteWeledkvPlstnalielrrrvrlwrekvdedpeegPvvvvssdGa

GRTGAFLVIDAMLRQAKKQKTVDIFNYVKAIREDRPHMVQTSEQYVFIHLAVL
.|.|..| ||| | ...|.. ||.|..|| .|..||..|.. |.| .|   .|
sRsGvylaidanlelvekeeevdvFeavktlrrsRpqLvenveeYkyiYdvll
subfamily_PTPN14_pd Subfamily PTPN14 3-240 1.4e-52 173.6 In-house 42-293 (300) alignment 
Range on Protein: 3-240
Range on HMM: 42-293/300.0
EAAKKRVNKAKNRYANIVTYDHSRVVLEKLSNDpHSDYINASYLRDYDG-SPKAYIATQGNICINAGDFWRMMWQERRCVIVMLTGLIEGHKKKCHQYWP
..||  .|. |||. ... |...|| |    .. ...||||| ..   | . . ||..|| . .   |||.|.|..   .|||||  .|. |.|...|.|
staklpenaeknrfkdvlPyednrvelsptken.stgyinassikvsvggkersyivaqgPleltvqdfWqmvWeqgvqlivmlteeeedgkeksfkyfP

DS-----TSKYCNLRVTLRKTEVFADYIIRTFVMSQVGQTEERYVYQYHFTVWPDKGVPQ-------YATAVLGLRRKITKDSL--PGARPWVIHCSAGV
..     | .. . .|| . .|    .| ... .  .   ||| |.   .| |||.|||.       |   |  .||| .. .       | ..||||||
kleskkktvefgkfkvttkfsedsdsvittglklkhlpskeertvwhlqytDWpdhgvPeDvkgflsyLeevqsvrrktnseveskeskPPvlvhCsaGv

GRTGAFLVIDAMLRQAKKQKTVDIFNYVKAIREDRPHMVQTSEQYVFIHLAVL
||||  .. | ..   ......|| . .. .|| | ..|||  || |.. ...
GrtGvlilsdlliatlehneeidikkvlarLreqrmllvqtlaqYkfvYkvli
0051429 (Phosphotyrosine protein) phosphatases II 36-241 1.6e-49 164.3 In-house 2-223 (272) alignment 
Range on Protein: 36-241
Range on HMM: 2-223/272.0
PHSDYINASYLRDYdGS---PKAYIATQGNICINAGDFWRMmWQERRCVIVMLTGLIEGHKKKCHQYWP-------------DSTSKYCNLRVTLRKTEV
| |.||||...  | |.   |.......|   ..| ||||. ....  .||.|... |  . ||..|||             . |  | .||||| ..|.
plsgyiNardvggy.grvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseel

FADYIIRTFVMSQV-GQTEERYVYQYHFTVWPDKGVPQYAtaVLGLRRKITKdslpgARPWVIHCSAGVGRTGAFLVIDAMLRQAKKQKTVD--------
. |||.|..... . . .| | |...|.| ||| |||| |  .| | . . .      .| ..|||||..||| . ... .|..  ..  ||        
lldyilrellltlllsagearevmhlhytdwpdhgvpqea..llellellld.....ggpvlvHCsaGkdRTGtvvallllllgvsletivddYlltnly

IFNYVKAIREDRPHMVQTSEQYVFIHLAVLE
....|. .|. ||..||| |||.|.. |.||
leeaveelraqrpgavqteeqylflyealle
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 4-239 4.7e-46 151.9 In-house 32-273 (287) alignment 
Range on Protein: 4-239
Range on HMM: 32-273/287.0
AAKKRVNKAKNRYANIVTYDHSRVVLEKLsNDPHSDYINASYLRDYDGSpKAYIATQGNICINAGDFWRMMWQERRCVIVMLTGLIEGHKKKCHQYWPDS
||..  .  |||||... .|..||.| .   .  |||||| |.  |    .|.||.|| |    .||||.....| ......|  .|  ..||..|||. 
aaeelaavkknryadvlPiddtrvllsae.gelGsdyinanyvasytdd.eafiaaqgPiaatvrdfwravletrsasvitmtreveearlkcykywPer

tSKYCNL---R-VTLRKTEVFADYIIRTFVMSQVGQTEERYVYQYHFTVWPDKGVPQY----ATAVLGLRRKIT-KDSLPGARPWVIHCSAGVGRTGAFL
  .   .     | | ..    .| .|.. . ..   | | | |...  ||||...      .  ||  ...|  . .  .. | |.|...|.||.| .|
.evPmrvGGysvvlldydikePeygvralrlidletrearvvkqldllswPdkvlaPtavglirfvldvkqhielardasevGPlvvhddvGiGrsGill

VIDAMLRQAKKQKTVDIFNYVKAIREDRPHMVQTSEQYVFIHLAV
 . ..... ..   ||. . |  .|| |  .||.  |. ..  |.
atlvlvsrledlGrvdvaavvirlreyraalvqavvqlrllyeal
0041856 (Phosphotyrosine protein) phosphatases II 10-241 5.5e-45 148.5 In-house 1-169 (182) alignment 
Range on Protein: 10-241
Range on HMM: 1-169/182.0
NKAKNRYANIVTYDHSRvvleklsndpHSDYINASYLRDYDGSPKaYIATQGNICINAGDFWRMMWQERRCVIVMLTglieghkkkCHQYWPdstskycn
|. |||| .|. |||||          ..|||||.... .  . . .|||||.   .  ||.||.....  .||.||         ...|||        
nldknrysdilpydhsr..........dldyInanlylgslpatr.fiatqgpllstvadflrmlkelgittivnlt.........eelywp........

lrvtlrktevfadyiirtfvmsqvgQTEERYVYQYHFTVWPDKGVPQyATAVLGLRRKITKdslpGARPWVIHCSAGVGRTGAFLVIDAMLRQakkqkTV
                         . .||...||... ||| |||     .| . ... .      .| ..||||||||||.. ... |...      |
.........................ellerlgiqylylpwpDhgvpd.ldelldfieevle....eggpvlVHCsaGvgRtgtlvaaylmkkl.....gv

DIFNYVKAIREDRPHMVQTSEQYVFIHLAVLE
.... || .|. ||.||.| .||.|..||.||
sleeavklvrsrRpgmvitpnqyfflqlalle
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 10-240 2.9e-43 142.6 In-house 56-280 (290) alignment 
Range on Protein: 10-240
Range on HMM: 56-280/290.0
NKAKNRYANIVTYDHSRVVLeklSNDPHSDYINASYLRdydGSPKAYIATQGNICINAGDFWRMMWQERRCVIVMLTGLIEGHKKKCHQYWPDSTSK---
.  |||| ..|  | .||.|   ..  . ||. | |..   |    .| ||| .   . |.|||. ||.  .||||  |||  | ||.||.|.   .   
efkknrykdvvcndktrvil...kdGydGdyvhanyvk...GlkamfiltqGalkdtvidiwrmvlqekvaaivmlceliedGkakceqyypekeGevlt

YCNLRVTLR-KTEVFADYIIRTFVMSQVGQTEERYVYQYHFTVWPDKGVPQYATAVLGLRRKITKDSlpGarPWVIHCSAGVGRTGAFLVIDAMLRQAKK
. .. |.   ...  |. | .|. . .. .  |  .. ..   |||| |.. . |.| . | . | |  |  | |.|||||.||||.|  |.. |.   .
fGeitvlcseeddkdaniikktlsvrdkdsGkehklkhlkikswpdksvalstlallrtlrilrkas..G..pvvvhcsaGiGrtGtfvaievglqilld

QKTVDIFNYVKAIREDRPHMVQTSEQYVFIHLAVL
 | .|. . |.|.|. |   ||   ||. .  ..|
Gkeldlldlvralrnsrlnsvqvdiqylalveill
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 10-238 2.1e-42 140.0 In-house 33-254 (267) alignment 
Range on Protein: 10-238
Range on HMM: 33-254/267.0
NKAKNRYANIVTYDHSRVVLEKLSNDphsdYINASYLRDYDGSpKAYIATQGNICINAGDFWRMMWQERRCVIVMLTGLIEGHkkkCHQYWPDS---TSK
|...||. . . ||..||.| .  ..    ||||||.  |    .|.|.||. .    .||. .. ...  |||.||   ..     ...||     . |
nqernrlddnlpyddtrvilrtkeee....yinasyvegyktk.nafivtqdplkntitdfltvihdqkvpvivlltkvftdn...irlfwPPkmgqakk

YCNLRVTLRKTEVFADYIIRTFVMSQVGQtEERYVYQYHFTVWPDK-GVPQYATAVLGLRRKITKDSlpGARPWVIHCSAGVGRTGAFLVIDAMLRQAKK
| .| |     .   || | |. .    .   . |  |..  |  .     |   ..|.  |   .   | || |..||.||||.|.|||||..|..||.
yqdltvehslekeendyqiitlelkfkne.sahnvtlyyykkwnintnnkpylkplfgilaknqlen..gnrPlvvacsdGvGrsGtflvidsqlerakt

QKTVDIFNYVKAIREDRPHMVQTSEQYVFIHLA
. ..|||.... ||. |. .|.| |.|..||  
egvsdifdflrkirsqriglvdtkeryiyihel
0036282 (Phosphotyrosine protein) phosphatases II 38-236 1.1e-41 137.7 In-house 2-163 (174) alignment 
Range on Protein: 38-236
Range on HMM: 2-163/174.0
SDYINASYLRDYDGSPkAYIATQGNICinagdFWRMMWQERRCVIVMLTGLIEGHKKKCHQYWPDstskycnlrvtlrktevfadyiirtfvmsqVGQTE
|||||||.|  .  .|  .||.||  .     ||.|.....  ..|||. ..| .. ||..|||.                                . .
sdyinaspldlsyitp.rliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe..............................lredl

ERYVYQYHFTVWPDKGVPQYATaVLGLRRKITKDSLP-GARPWVIHCSAGVGRTGAFLVIDAMLRQAKkQKTVDIFNYVKAIREDRPHMVQTSEQYVFIH
||...||... ||| |||  .. .| . . . .  .  . .| ..||||||||||.. ... |||. . ...||....|...|  ||.|||| .|| |..
erlgiqylylpwpDhgvpdlsi.llefvkfveealsedpggpvlVHCsaGvgRtGtlvaaylmlrgll.eslvdaldlvrelRlqrpgmvqtpsQyrfly
0046846 (Phosphotyrosine protein) phosphatases II 31-240 1.9e-40 133.8 In-house 5-170 (176) alignment 
Range on Protein: 31-240
Range on HMM: 5-170/176.0
KLSNDPHSDYINASYLRDYdgspkAYIATQGNICINAGDFWRMMWQERRCVIVMLTGLIEGHKKKCHQYWPDSTSKYCnlrvtlrktevfadyiirtfvm
.|  |...|||||...  .     ..|||||... .  ||..|.....  ..|.|| ..| .. ||..|||. ..  .                      
llgldldldyinanlilgs.....rpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgi......................

sqvgqteeryvyQYHFTVWPDKGVPQYaTAVLGLRRKITKDSLPGaRPWVIHCSAGVGRTGAFLVIDAMLRqakkQKTVDIFNYVKAIREDRP-HMVQTS
            ||... ||| |||.. ...| | . | .    | .| ..|||||.||||...... . .    .| ..... .. .|| || ..||| 
............qylhlpwpDhgvpdl.elllellefirealkeg.gpvlVHCsaGigRtgtlvaayllel....ekglsveealalvreqRplgavqtp

EQYVFIHLAVL
||| |.. ..|
eQyrflyefel
subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 6-240 2.3e-39 129.8 In-house 33-266 (281) alignment 
Range on Protein: 6-240
Range on HMM: 33-266/281.0
KKRVNKAKNRYANIVTYDHSRVVLEK-LSNDPHSDYINASYLRDYdGSPKAYIATQGNICINAGDFWRMMWQERRCVIVMLTGLIEGHKKKCHQYWPDST
.. ||. ||||.||   | ||| |.  . |   .||| | |.|      . || |||       |||||.|||    ||||  ..|  ..|| .|.|  .
nqpvnnkknrylnipcldisrvqlkvkmpnknstdyihanyirsp.flkrgyiltqgpkketradfwrmiwqenttaivmlcqfletnrekcaeyfprna

---SKYCNLRVTLRKTEVFADYIIRTFVMSQVGqtEERYVYQYHFTVWPDKGVPQYATAVLGLRRKITKDSLPgarpWVIHCSAGVGRTGAFLVIDAMLR
    .. .| |.   . |    .   . .|  |  | | . .. .  |||  ||. .  .| . |||   | |     ||||||||||.|... ..  |.
hcclqfdklsvsyedstvnkslvttrlnlsyeg..etrlithwlwkewpdwqvpessevmlkilrkirarstp....pvihcsagvgrsgtlmaveialq

QAKKQKTV-DIFNYVKAIRE-DRPHMVQTSEQYVFIHLAVL
  . . |. || . |  .|   |   ||| .||..|   .|
sihshftlpdikqivshlrvtgraasvqtlqqymliwkvll
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 8-241 2e-38 127.1 In-house 39-275 (307) alignment 
Range on Protein: 8-241
Range on HMM: 39-275/307.0
RVNKAKNRYANIVTYDHSRVVLEKlsNDPHSDYINASYLRdYDGSPKAYIATQGNICINAGDFWRMMWQERRCVIVMLTGLIEGHKKKCHQYWPDST---
. |  |||| ..   |..|.|..   .   |||| | ||      || .|..||       .|| |. ||.   ..||  .||  | ||.||||      
santdknryqdvkcqdkgrivvkf..dglasdyihanylg.iaikpkkficaqgplentqysfwamaiqekvesvimlckvielakikceqywpleegqk

SKYCNLRVTLRKTEV------FADYIIRTFVMSQVGQTEERYVYQYHFTVWPDKGVPQYATAVLGLRRKITKDSlpgaRPWVIHCSAGVGRTGAFLVIDA
  ...   |.  ...        . .|    .  .   . | . .. .. |||.||||   . . |   .  |      | |.||||||||.|. . |  
lvfgeapntisvanlgakklapdedlinvttlkvdwaqksrtiqhlqwenwpdrgvpqinltainlleavrydt....npvvvhcsaGvGrsGtivaisl

MLRQ-AKKQKTVDIFNYVKAIREDRPHMVQTSEQYVFIHLAVLE
.  .  . .   |. . |. .|..|.. .||  ||...|  .||
vqdkmiaGinckdmkklveelrsqrhyaiqteaqylylhrvlle
0049772 (Phosphotyrosine protein) phosphatases II 5-241 4.3e-37 123.9 In-house 41-278 (314) alignment 
Range on Protein: 5-241
Range on HMM: 41-278/314.0
AKKRVNKAKNRYANIVTYDhSRVVLEKLSNDPhSDYINASYLRDYdgspKAYIATQGNICINAGDF----------WRMM--WQERRCVIVM--------
|.. .|. |||| .|. .| .||.| .|...  ||||||||.. .    ...|||||   |.  ||          |||.  .. .  .|||        
adlflnrdknryldilpad.nrvilpglpvsg.sdyinasyvdgf....lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivmsrdevlad

-------------LTGLIEGHkkkchQYWpdSTSKY---CnlrvtlrktevfadY-------IirtfvmsqvgqteERYVYQYHFTVWPDKGVPqYATAV
             |..| ...      ..  . . .   .                                    ||....|. . .|| ..|     .
elsrLdaAlgKtpllildgng.....nep..taadlellk..............eelydpelf.............erlgikylripvpDgsap.lledf

LGLRRKITKDslPGARPWVIHCSAGVGRTGAFLVIDAMLRQAKKqKTVDIFNYVKAIRE--DRPHMVQTSEQYVFIHLAVLE
. . . | .   .  .| ..||.||.|||| |.|.. .... .     .....|...|    .|..... |||.||. |.||
deflefieea..dkggpvlvHCkaGkgRtgtfvvaaylmkllgv.sleealedvrlkRpinpnpgfieqleqyefilealle
0043147 (Phosphotyrosine protein) phosphatases II 35-236 5.1e-37 122.6 In-house 2-154 (172) alignment 
Range on Protein: 35-236
Range on HMM: 2-154/172.0
DPHSDYINASYLRDYDgSPKAYIATQGNICINAGDFWRMMWQERRCVIVMLTGLieghkkkchqywpdstskycnlrvtlrktevfadyiirtfvmSQVG
|..|||||||||  |   |. .|||||  . .  |||||....   .||.||.|                                             .
degsdyinasyldlyy.ipdrfiatqgplrntladfwrmlkelgithivnltel..........................................lydp

QTEERYVYQYHFTVWPDKGVPqYATAVLGLRRKITK-DSLPGARPWVIHCSAGVGRTGAFLVIDAMLrqakkqKTVDIFNYVKAIREDRPHMVQTSEQYV
. .||...||... ||| |||  .  .| . . | .   |    | ..||||||||||.. ... ||      . ..... |. .|| ||..||. .|| 
ellerlgiqylylpwpDhgvp.llellleflefidellalspggpvlVHCsaGvgRtgtlvaaylml......lglsleeavalvrekRpgavqnpsqyr

FIH
|..
fly
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 4-240 5.8e-37 122.1 In-house 42-284 (305) alignment 
Range on Protein: 4-240
Range on HMM: 42-284/305.0
AAKKRVNKAKNRYANIVTYDHSRVVLEklSNDPHsDYINASYLRDyDGSPKAYIATQGNICINAGDFWRMMWQERRCVIVMLTGLIEGHKKKCHQYWPDS
| |.  .. |||| ..   |. || ||  .  || .|| | |.      || .| ||  .     ||| | .|..   | ||  |.|   |||..|..  
afkeaqeagknrykdvgcldnnrvkle..gpwph.eyihanyvst.ptnpkrfictqaplektcadfwymclqdkveaifmlcnllekgakkcleyfask

TSKYCNLRVTLRKTEV---------FA----DYIIRTFVMSQVGQTEERYVYQYHFTVWPDKGVPQYATAVLGLRRKitkdSLPGARPWVIHCSAGVGRT
  .  ...   .|  |         |       . .| .. .   .. | | .||.  |||.|||   .|.| |  |    . |   | |.|||||.|||
dkdvlefeekgqkisvkfessvtlkfrkdakakvtetvlviegpgekarkvthyhwidwpdrgvpaadlailellek....arpskgpivvhcsagigrt

GAFLVIDAMLRQAKKQKTVDIF-NYVKAIREDRPHMVQTSEQYVFIHLAVL
|. .... .| |    . ..     .. |||.|   .|| .||.|.|  .|
gsvvmleyildqllagqiiedtdkilqkireqrnnsiqtdaqylfvhqvil
0049260 (Phosphotyrosine protein) phosphatases II 51-236 4.7e-36 119.1 In-house 6-143 (152) alignment 
Range on Protein: 51-236
Range on HMM: 6-143/152.0
GSPKAYIATQGNICINAGDFWRMMWQERRCVIVMLTGLIEGHKKKCHQYWpdstskycnlrvtlrktevfadyiirtfvmsqvgqteeryvyQYHFTVWP
. |...|||||  . .. |||||...    .||||| | | .| ||.||.                                          ||... ||
ampfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi..........................................qylhlpwp

DKGVPQYATAVLGLRRKITKDSLPGARPWVIHCSAGVGRTGAFLVIDAMLrqakkqKTVDIFNYVKAIREDRPHMVQTSEQYVFIH
| |||. .  .| | . | |  |    | ..||||||||||.. ... ||      . |.....|. .|| ||..|.. .|. |..
DhgvpdlsqlllflllfieklaldkggpvlVHCsaGvgRtgtlvaaylml......lgvsleeavalvrekRpgavpnpgqlrfly
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 8-240 4.9e-36 118.9 In-house 53-286 (305) alignment 
Range on Protein: 8-240
Range on HMM: 53-286/305.0
RVNKAKNRYANIVTYDHSRVVLEKLSndpHSDYINASYLRDYDGSPKAYIATQGNICINAGDFWRMMWQERRCVIVMLTGLIEGHKKKCHQYWPDSTSKY
 ....||||...   |.| | |.| |    |||| | |.       | .|..|| .     .|| |. |..   ||||   .|  | || |||| .  . 
diaitknryqdvpcqdqsavkldkps...psdyihanyvgcpmipekrficaqgpldqtidefwwmviqnkveqivmlcktvelgklkcaqywpaaqgek

CNLRVTLRKTEVF--------ADYIIRTFVMSQVGQtEERYVYQYHFTVWPDKGVPQYATAVLGLRRKITKDSLpgarPWVIHCSAGVGRTGAFLVIDAM
 .|.  .   .|         |.  | .. ..  |. ..  | . ..| |||.|||    . | |   |    .    | |.|||||.||||. . |. .
lelksgivvenvsgskpmerdaeiqitllnltysgd.qkmsvrhlqwtewpdrgvppckltslellsairgskv....pivvhcsagigrtgtivaieyi

LRQAKK-QKTVDIFNYVKAIREDRPHMVQTSEQYVFIHLAVL
| .  . ..   . . |||.|..| . .|.  ||.|||  .|
lekiaenkpcppmpelvkalrdqrafsiqndvqylfihrvml
subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 9-241 1.3e-35 117.8 In-house 34-268 (285) alignment 
Range on Protein: 9-241
Range on HMM: 34-268/285.0
VNKAKNRYANIVTYDHSRVVLEKLsndpHSDYINASYLRDYDGSPKAYIATQGNICINAGDFWRMMWQERRCVIVMLTGLIEGHKKKCHQYWPDST---S
 |   ||||..   . .||||..       ||| ||..|       .||.||| .     |||.|..||. . ..||  |.||  .||  |.|.      
anpdlnryadvrcieetrvvlknh....drdyihaswmrmpgkdqstyittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekcalyypeklgevv

KYCNLRVTLR--KTEVFADYIIRTFVMSQVGQTEERYVYQYHF--TVWPDKGVPQYATAVLGLRRKItKDSLPGARPWVIHCSAGVGRTGAFLVIDAMLR
|. .  .||   | |  |  |. .. . .  ..    .|  |     |||.  |. |  .. | . . |   |  .| ..||||||||| .|. ||    
kfgkyeitlteckeeaiagtilnaltvintedasseplymnhvqvpwwpdqlapedarpmielykwv.kkvnpkekpicvhcsagvgrtatfvgidyati

QAKKQKTVDIFNYVKAIREDRPHMVQTSEQYVFIHLAVLE
.  ..  ..... |. .|  | . ||.  |..|... ..|
rimenpniemldivremramrfqavqshmqflflyvvlme
subfamily_CG42327_pd Subfamily CG42327 10-164 3.5e-35 116.2 In-house 28-186 (319) alignment 
Range on Protein: 10-164
Range on HMM: 28-186/319.0
NKAKNRYANIVTYDHSRVVLEKLSNDPHSDYINASYLRDYDGSPKAYIATQGNICINAGDFWRMMWQERRCVIVMLTGLIEGHKKKCHQYWP-----DST
 | |.|..|.|   ..||||.. ..|... |..|||.| || .|  |||.| .    . ||||..|. .  ||| || | |   |.| .|.|     |.|
skdksrvinvvPlPetrvvlqrigdddkdeyldasyvrGyddapnsyiaaqvsledsssdfwrtvweqqsrvivqltdlselGikvcaeylPtketldnt

SKYCNLRVTLRKTEVFADYIIRTFVMSQVGQTEERYVYQYHFtVWPDKGVPQYATAVLGL
| | ...|||.. ||   |.| |... .| . | | .  | .  |.. .||   .|.. .
slyGdilvtlkgrevkdryaistlllkrvdkeesrelthywy.kwleaevPaeeaaliam
subfamily_ptpA1_pd Subfamily ptpA1 5-202 1.1e-34 114.9 In-house 42-255 (418) alignment 
Range on Protein: 5-202
Range on HMM: 42-255/418.0
AKKRVNKAKNRYANIVTYDHSRVVLEKLSNDPHSDYINASYLRdyDGSPKAYIATQGNICINAGDFWRMMWQERRCVIVMLTGLIEGHKKKCHQYWPDST
  |. | .||||.||.  .|.|| |.|. .   |||||| |.      || .|.||| .     |||||.|..|  .||||.   |  . || .|||.  
gdkkhntsknrytnilpvnhtrvqlkkiqdkegsdyinanyid..gaypkqfictqgplpntiadfwrmvwenrcriivmlsresencrikcdrywpeqi

SKyCNLRVTLRKTEVFADYII-------------RTFVMSQVGQTEERYVYQYHFTVWPDKGVPQYATAVLGLRRKITKD---SLPG---ARPWVIHCSA
    .. .     |||  | .              |  .    . | | . ||..  |||. .|...  .  | . ||.     .|      | ..||||
gg.eqfsiygngnevfgtysvelveviqdpereiitrnirltfegetrditqyqyegwpdhnipdhtqpfrqllhsitnrqnqiipssdrnvpiivhcsa

GVGRTGAFLVIDAMLRQ
||||||.|     |...
gvgrtgtfctavimmkk
0044763 (Phosphotyrosine protein) phosphatases II 22-237 2.3e-33 110.7 In-house 2-165 (178) alignment 
Range on Protein: 22-237
Range on HMM: 2-165/178.0
YDHSRVVLEKLSNDPHSDYINASYLRDYdgspkAYIATQGNicinaGDFWRMMWQERRCVIVMLTGLIEGHKKKCHQYWPDSTSkycnlrvtlrktevfa
.|..||.|..|.. . |||||||.  ..      |......      |........   .||.||. .|... ||..|||....                
ldrtrvllsnleglersdyinaseilpg.....lylgslpp.....addlellkelgithivnlteelelgflkcdpywpeeag................

dyiirtfvmsqvgqteeryvYQYHFTVWPDKGVPQYATAVLGLRRKITKDSLPGARPWVIHCSAGVGRTGAFLVIDAMLRQakkqkTVDIFNYVKAIRED
                    .||... .|| |||.    .| . . | .   .  .| ..||||||||.|.. ... |...      ..... .. .|| 
....................iqylhipipDhgvpdllehflefvefieealdekggpvlVHCsaGvgRsgtlvaaylmkkl.....glsleeaielvrer

RPhMVQTSEQYVFIHL
|| .|.. .|. ....
Rp.ivpnpgqlrqLye
PTPc_DSPc_SM00012 141-241 1.4e-32 107.4 In-house 2-105 (105) alignment 
Range on Protein: 141-241
Range on HMM: 2-105/105.0
VYQYHFTVWPDKGVPQYATAVLGLRRKITKDSLPGA--RPWVIHCSAGVGRTGAFLVIDAMLRQAKKQ-KTVDIFNYVKAIREDRPHMVQTSEQYVFIHL
|..||.| |||.|||......| | |.. |     .   | |.|||||||||| | ..| .|.| .|. |.||||..||..|. ||.|||| |||.|.. 
vkhyhytgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqylflyr

AVLE
|.||
alle
0051082 (Phosphotyrosine protein) phosphatases II 36-240 1.6e-32 107.6 In-house 1-150 (151) alignment 
Range on Protein: 36-240
Range on HMM: 1-150/151.0
PHSDYINASYLRDYdgspkaYIATQGNicinAGDFWRMMWQERRCVIVMLTGLIEGHkkKCHQYWPDSTskycnlrvtlrktevfadyiirtfvmsqvgq
|.|||||.||. ..      .....|       ||.......   .||.|... |    .|..|.|.                                 
plsdyinfsyvtgg......lyrsggp....ladflellkelgiktivnlrseeerg..ycpeylpelg...............................

teeRYVYQYHFTVWPDKGVPQYATAVLGLRRKITKdslPGARPWVIHCSAGVGRTGAFLVIDAMLRQakkqktVDIFNYVKAIREDRPHMVQTSEQYVFI
   . |...... ||| |.|..  ||| . ... .   ..  | ..|||||.||||.. ... ||..      |...  .. .|. ||..||...|..|.
...ievlhipildwpdpglplsfdavleflellld...kkngpvlvHCsaGkgRTGtlvalylmllg......vsleealeeyrlkrpgvvqpnqqflfq

HLAVL
..|.|
lfall
subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 10-238 8.8e-32 105.0 In-house 50-276 (301) alignment 
Range on Protein: 10-238
Range on HMM: 50-276/301.0
NKAKNRYANIVTYDHSRVvlEKLSN----DPHSDYINASylrdydGSPKAYIATQGNICINAGDFWRMMWQERRCVIVMLTGLIEGHKKKCHQYWPDSTS
.| |.|| ..    .. |  | ...      |...|..|      | |. .||||| .   . ||| |. |     ||||.  .| ...||..| | ..|
pkdkhryptvPckPstav..evivdGkrvPihanwipts......GhphrfiatqgPlkntsedfwamlvqydvekivmlgqkvekleekceeylpvkis

KYCNL---RVTLRKTE-VFADYII-RTF-VMSQVGQTEERYVYQYHFTVWPDKGVPQYATAVLGLRrKITKDSlpgARPWVIHCSAGVGRTGAFLVIDAM
.  ..   .......| .. . |. ||. |    |. . | |  | .. |.|.|||.  . .  |  .. |.|    .| |.|||||.||. ||.  . .
ekldigrfkikiknkelilnkkiskrtlevedstgkfatrtvthyqysewtdrgvPkshaelfdlm.elvkks...ekPivvhcsaGiGrsvafigteyl

LRQAKKQKTVDIFNYVKAIREDRPHMVQTSEQYVFIHLA
 |. . ..|... . .| .||.| . ||| .|  .. | 
areveadptieltealkhlrehrwngvqtnsqlywmtlG
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 10-241 3.6e-31 103.3 In-house 43-269 (288) alignment 
Range on Protein: 10-241
Range on HMM: 43-269/288.0
NKAKNRYANIVTYDHSRVVLEklsNDPHSdYINASYLRdYDGSPKAYIATQGNICINAGDFWRMMWQERRCVIVMLTGLIEGHKKKCHQYWPDSTSKYCN
| ...|| |.   | .|| |.   .||.  ||.|  .      ..  | .|  .    . .|.|. ..    ||||. |.|  |.|  .|.|    .   
nptrdryenlprcditrvkls...ddpdf.yiaanvvs.sakykrrlicaqaPlngtieelWkmllesdveyivmlcellekGkeksaeyfPsklGekar

LRVTLRKTEVFADYIIRTFVMSQVGQTE---ER-YVYQYHFTVWPDKGVPQYATAVLGLRRKItkDSLpgARPWVIHCSAGVGRTGAFLVIDAMLRQAKK
..     . .  . | .. ..| .  ..   |. .| . |.  |.|.|||.   . | |   .   ||   .| |.|.||||||||.. .|  .|.... 
igrlctvvkkkradidklvkvsllriskegeekvivkilhlleWdddgvPenylsplrllevl..ksl..qkPivvhssaGvGrtgtlililialeslrl

QKTVDIFNYVKAIREDRPHMVQTSEQYVFIHLAVLE
.  . | . ..  ||.| . .||  ||...|  |||
ddflgirsllaklreerfkaiqtemqylyvhrcvle
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 121-241 9.2e-31 101.6 In-house 75-192 (440) alignment 
Range on Protein: 121-241
Range on HMM: 75-192/440.0
ADYIIRTFVmsqvGQTEERYVYQYHFTVWPDKGVPQYATAVLGLRRKITKD-SLPGARPWVIHCSAGVGRTGAFLVIDAMLRQAKKQKTVDIFNYVKAIR
.|||  ...       | | . |||.  |||||||..|  || . . . .     |  | ..|||||.||||  ...|..||.||.   .|||......|
sdyinasyi....ngiesrtlkqyhyqgwpdkgvpkfagpvlkmiqdvnesqekagngpllvhcsagagrtgviiavdsilreakrsdqidifsfinsmr

EDRPHMVQTSEQYVFIHLAVLE
..||.|||| |||.|.| ||||
nnrpqmvqtpeqyafvheavle
subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 10-238 1.6e-29 97.5 In-house 52-285 (310) alignment 
Range on Protein: 10-238
Range on HMM: 52-285/310.0
NKAKNRYANIVTYDHSRVVLeKLSNDPHSDYINASYLRDyDGSPKAYIATQGNICINAGDFWRMMWQERRCVIVMLTGLIEGHKKKCHQYWPD--STSKY
.  ||||...|  | ||| | |. .  . ||| | |..  .   ...| .|| .     |||||..|||   |..|    |  . ||  |||    |  |
ymhknrysdvvcldtsrvkl.kidksryedyihanyvkt.nylrstficsqgplqhtiidfwrmifqeraesilllckvgeegrpkcvgywpslgvtety

CNLRVTLRK--TEVF-ADYIIRTFVMSQVG------QTEERYVYQYHFTVWPDKGVPQYATAVLGLRrKITKdSLPGarPWVIHCSAGVGRTGAFLVIDA
  .|||     .| |    .  |||  .|       . .|  |   ..  |||.|||.     .  |  ...    |  | |.|||||..|... . .. 
gcirvtnlsesseefeicnlavtfvpdnvpvdeqpanlkelrvslikwpnwpdrgvpdekchtvpqr.llaq.vrhg..pcvvhcsagkdrlyvvvalkl

MLRQAKKQKTVDIFNYVKAIREDRPHMVQTSEQYVFIHLA
 . .... . ||. . .  .. .|   .||  ||..|.  
kidkldrglkvdaeevktellksraiciqtelqyliidrv
subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 11-241 3.6e-28 93.2 In-house 44-274 (312) alignment 
Range on Protein: 11-241
Range on HMM: 44-274/312.0
KAKNRYANIVTYDHSRVVLEKlsnDpHSDYINASYLRdYDGSPKAYIATQGNICINAGDFWRMMWQERRCVIVMLTGLIEGHKKKCHQYWPDSTsKYCNL
|  ||| ||  .|  |  |     |    || | ...     |. ...||| .   .  ||..      . |..|.|..|   .|| .|  |    . .|
kdlnrypniqcwdrgrftlag...d.enfyihanfvk.ictkperfvctqgplentcthfwqlalslgstsiillcgfvedgsekcakyisdiv.gfvdl

RVTLRKTEVFA---------DYIIRTF---VMSQVGQteERYVYQYHFTVWPDKGVPQYATAVLGLRRKITKDSlpgaRPWVIHCSAGVGRTGAFLVIDA
      ||  .         | |       |.   ||  |  . .| .. |||.|.|.   . | |   . ||     .| . ||||||||||.. .|..
edhrvyteycteieiggkskdkithrvlkvvvkatgq..esklnhyqwaswpdhgmpdscdtalrllsavkkdk....kpviahcsagvgrtgtlalies

M---LRQAKKQKTVDIFNYvkaIREDRPHMVQTSEQYVFIHLAVLE
|   ||. .||.  |.|     .| ||   |..  |||.   .|||
miaalrhprkqnvkdsfvl...lrkdrarsvrvfpqyvyalrcvle
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 5-156 8.7e-26 85.4 In-house 28-181 (297) alignment 
Range on Protein: 5-156
Range on HMM: 28-181/297.0
AKKRVNKAKNRYANIVTYDHSRVVLEKlsNDPHSDYINASYLRDYD-GSPKAYIATQGNICINAGDFWRMMWQERRCVIVMLTGLIEGHKKKCHQYWPDS
||.     |||| .|...| .|| | .    . .||||| |.   |  ..  || .|| .     |||......   ||||.. | |. ..||  |||..
akrnsslrknryrdilatddtrvkllr..viterdyinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmvaklqedGrdkcapywpsv

TSKYCN-LRVTLRKTEV----FADYIIrTfVMSQVGQTEERYVYQYHFTVWPDKGVPQ
  .  .   | .         |   |. |  .  . ..|.|.|    |  |||.||| 
vqerlkagdvvveflsstsdefdrvil.t.elqliyrsesrvvrhvqflswpdhGvps
subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 10-240 4e-25 82.8 In-house 51-282 (302) alignment 
Range on Protein: 10-240
Range on HMM: 51-282/302.0
NKAKNRYANIVTYDHSRVVLEKlsnDPhSDYINASYLRDYDGSPKAYIATQGNICIN--AGDFWRMMWQERRCVIVMLTGLIEGHKkKCHQYWP---DST
| .||.  ..  .|. .| ||.    |  .|.||| .   . ... ..|   .   .    .||||..||.   .|.| |  | .|   ....|   .. 
nlkknqsedvpildsnlvklea...ep.dsyvnaskvevPeltrsiilaQlpkvdsedsveeFWrmvfqekivsvvilvgeeelkk.tlselfpkksgdy

SKYCNLRVTLRKTEVFADYIiRTFVMSQV--GQTEERYVYQYHFTVWPDKGVPQYATAVLGLRRKITKDSLPGARPWVIHCSAGVGRTGAFLVIDAMLRQ
..| ...|  || |   .     .|.  .  | ..   .  |..| |..| ||.  ...     |. . . ..  . ||    |.|| ||||.  . . .
keygkmfvNnrkVekaeeek.tryviEvlPegcsnsvlanvyvltnWkqkkvpvkyaeliktaakvfakkikadentvivSknGaGRagafltlavavek

AKKQKTVDIFNYVKAIREDRPHMVQTSEQYVFIHLAVL
 .|.| . | . ||.||..||..|.. .|||....|.|
lqkgkepnikeivksiRsqRpravdslkQyvslyiall
subfamily_egg_pd Subfamily egg 9-240 4.2e-24 79.8 In-house 39-267 (307) alignment 
Range on Protein: 9-240
Range on HMM: 39-267/307.0
VNKAKNRYANIVTYDHSRVVLEKLSNDPHSDYINASYLRdydGSP--KAYIATQGNICINAGDFWRMMWQERRCVIVMLTGLIEGhkKKCHQYWPDSTSK
 |. | |   .   | ||| ||        |.| | ...   | |    .| .|  .     |||||..||.   |||||   |   ..|. ||| . |.
nnlekarskrvhckdssrvklelrrGqylddfihanrvk...Gkpllnefilaqaplkntvddfwrmvfqeevqyivmltsrkes..erceyywpkaesd

YC-----NLRVTLRKTEVFADYIIRTFVMSQVGQ-TEERYVYQYHFTvWPDKGVPQYATAVLGLRRKITKdslpgarPWVIHCSAGVGRTGAFLVIDAML
       .||..  | .  || . |   .  ||   |||..  .    .   .   .   || . |...|       | |...  || ...... |.  |
slvtvpGslrienlkvdskadplfrvtklklvGgddeerflehwqgd.vnnssdvysplrvlrklrnlsk.......pvvvqdilGvskaatlvaieial

RQAKKQK--TVDIFNYVKAIREDRPHMVQTSEQYVFIHLAVL
 .  .       . . |. .|  |.  |..  .|.|..  ||
lsllrGpitkslvlravvflrlrrrlsvesvllylfvyrlvl
0048076 (Phosphotyrosine protein) phosphatases II 114-239 1.6e-23 78.4 In-house 19-139 (145) alignment 
Range on Protein: 114-239
Range on HMM: 19-139/145.0
LRKTEVFADYIIRT-FVMSQVGQTEERYVYQYHFTVWPDKGVPQYATAVLGLRRKITKDSLPGaRPWVIHCSAGVGRTGAFLVIDAMLRqakkqKTVDIF
 .. | ..|. |.| . ..   . .||...||... ||| |||. .  .| . . | .    | .| ..||||||||||.. ... ||.     . |...
aldlellkdlgittvlnltselellerlgiqylylpwpDhgvpdllellleflefieealkeg.gpvlVHCsaGvgRtgtlvaaylmll.....lgvsle

NYVKAIREDRPHMVQTSEQYVFIHLAV
. .. .|. ||..|.. .|. |.....
ealelvrsqrpgavpnpgqlrflyefe
0048179 (Phosphotyrosine protein) phosphatases II 125-237 2.8e-23 77.6 In-house 33-139 (144) alignment 
Range on Protein: 125-237
Range on HMM: 33-139/144.0
IRTFVMSQVGQTEERYVYQYHFTVWPDKGVPQYATAVLGLRRKITKDSLPGaRPWVIHCSAGVGRTGAFLVIDAMLrqakKQKtVDIFNYVKAIREDRPH
. ... .   . .||...||... ||| |||.... .| . . | .   .| .| ..||||||||||.. ... |.    |.. ..... .. .|. ||.
vinlteeyepefleregiqylhlpwpDhgvpdllellleflefieealeeg.gpvlVHCsaGvgRtgtlvaaylmk....klg.lsleealalvrsrrpg

MVQTSEQYVFIHL
.|.. .|. |...
avpnpgqlrfLle
subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 54-236 6.2e-23 76.0 In-house 4-196 (198) alignment 
Range on Protein: 54-236
Range on HMM: 4-196/198.0
KAYIATQGNICINAGDFWRMMWQERRCVIVMLTGLIEGHKKKCHQYWPD---STSKYCNLRVTLRKTEVFADYIIRTFVMSQV--GQTEERYVYQYHFTV
. |||||  .     |||.|.|.     |||.      ..     |||    .|.|| .| || .   . .|| | ......        | . .| || 
rryiatqhplretladfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqfts

WPDKGVPQYATAV---LGLRRKITKDSLPGARPWVIHCSAGVGRTGAFLVIDAMLRQAKKQKT--VDIFNYVKAIREDRPHMVQTSEQYVFIH
| .|  |. |  |   .  |    |       | ..||| | | || |. .|  .|  .. ||  ||.|.  | .|. |  .. . ..| ||.
wkekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiy
subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 54-236 6.3e-23 76.0 In-house 5-197 (199) alignment 
Range on Protein: 54-236
Range on HMM: 5-197/199.0
KAYIATQGNICINAGDFWRMMWQERRCVIVMLTGLIEGHKKKCHQYWPD---STSKYCNLRVTLRKTEVFADYIIRTFVMSQV--GQTEERYVYQYHFTV
. |||||  .     |||.|.|.     |||.      ..     |||    .|.|| .| || .   . .|| | ......        | . .| || 
rryiatqhplretmadfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqfts

WPDKGVPQYATAV---LGLRRKITKDSLPGARPWVIHCSAGVGRTGAFLVIDAMLRQAKKQKT--VDIFNYVKAIREDRPHMVQTSEQYVFIH
| .|  |. |  |   .  |    |       | ..||| | | || |. .|  .|  .. ||  ||.|.  | .|. |  .. . ..| ||.
wkekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiy
subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 67-240 8.3e-23 75.8 In-house 41-218 (255) alignment 
Range on Protein: 67-240
Range on HMM: 41-218/255.0
AGDFWRMMWQERRCVIVMLTGLIEGHKKKCHQYWP---DSTSKYCNLRVTLRKteVFADYIIRTFV-MSQVG-QTEERYVYQYHFTVWPDKGVPQYATAV
   |.... | .  |.|||. . |  ..||..|.|   |   |. .. ||  |    || ..|| . .|..| . . . |  |... |..|  |. |  .
vdkfyqtivqtktevvvmlcdfaeegvekcssyfplekdeklkladvnvtttk..ssadvvlrtleitstlgekkkthtvkhysykGWieknaPelarei

LGLRRkITKDSlpgaRPWVIHCSAGVGRTGAFLVID----AMLRQAKKQKTVDIfNYV---KAIREDRPHMVQTSEQYVFIHLAVL
| . . . .||    .. |.|||.|.||. || ...     |.|. .. .||.. .|.   . .|. |.  ..|  |  |  | ||
lnilk.vvrds....ksvvvhCstGiGrsaafvlaelvyqkmirsldttetvel.dylslleelrskrkraihtPlqlafsilmvl
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 11-113 1.9e-22 74.4 In-house 48-163 (350) alignment 
Range on Protein: 11-113
Range on HMM: 48-163/350.0
KAKNRYANIVTYDHSRVVLEKLSND--------PHSDYINASYLRDY----DGSPKA-YIATQGNICINAGDFWRMMWQERRCVIVMLTGLIEGHKKKCH
 ||||| ||. |.|||| |.|  .           .|||||.||.      .  |.  |||||. .     ||.... .    ||..|| ..|   .||.
faknrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvkvilsltsdvelnlekcy

QYWPDSTSKYCNLRVT
.||.. . .  .....
rYWqegsydditvkla
subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 10-238 4.6e-20 66.4 In-house 47-274 (303) alignment 
Range on Protein: 10-238
Range on HMM: 47-274/303.0
NKAKNRYANIVTYDHSRVVLEklsNdphSDYINASYLrDYDGSPKAyIATQGNICINAGDFWRMMWQER-RCVIVMLTGlIEGHKKKCHQYWPDSTS--K
|  |||.....  |||.| |    .   | || |||| . | | || | ||  .   | |||.|. ... .||...||   | .|   .  .|      |
nmdknrfvdvicldhskvkls...d...ssyihasyl.eldsskka.iltqlplshtaadfwqmiieqkvkcvlllltd.seydklggdsvfprnqdflk

Y--CNLRVT-LRKTEVFADYIIRtfVMSQVGQTEERYVYQYHFTVWPDKGVPQY-----ATAVLGLRRKITKDSlpGARPWVIHCSAGVGRTGAFLVID-
.    .||  ... |.   . ..  |.|    .   ... .|.  || . .|          .  |.  . | |   ..| |    .|.||.|.| ... 
feersirvgefkrvelgdgwvlk..vlsvsngdyksflhvhhykawphnsipsdgspkfvkqiwqlqsvlrkys..dstptvymslsgcgragtfalfet

AMLRQAKKQKTVDIFNYVKAIREDRPHMVQTSEQYVFIHLA
| |   ..| ..|. . .. .|. | | ||   |. ...  
ahlslhseqasldlvkclenvrngrlhavqnlsqfsvvytl
subfamily_hpo-7_pd Subfamily hpo-7 69-240 9.6e-20 65.6 In-house 49-224 (263) alignment 
Range on Protein: 69-240
Range on HMM: 49-224/263.0
DFWRMMWQERRCVIVMLTGLIEGHKKKCHQYWP---DSTSKYCNLRVTlrKTEVFADYIIRTFVMSQ-VG-QTEERYVYQYHFTVWPDKGVPQYATAVLG
 |.... | .  |.|||.   |  ..|| .|.|   |   |. |. |.   |.|  | ...| .. . .| . . . | .| .. |..|  |. |  .| 
kfyqtivqtktevvvmLcDfneegvekcssyfPlekdekqklanvnvc..ttkvqsdvllktlellstlgeKkkthtvkhysykgWiekndpelareiln

LRrKITKDSlpgaRPWVIHCSAGVGRTGAFLVID----AMLRQAKKQKTVDIfNYV---KAIREDRPHMVQTSEQYVFIHLAVL
.  |....|    .. |.|||.|.||. || |..     |.|. .. .||.. .|.   . .|. |.  ..|  |  |  | ||
il.kvarns....kslvvhcstGiGrsaafsvaElvyqkmirsldttstvel.dylsLleelrssrkraihtPmqLafsilmvL
subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 69-239 1.4e-18 61.4 In-house 106-284 (302) alignment 
Range on Protein: 69-239
Range on HMM: 106-284/302.0
DFWRMMWQERRCVIVMLTGLIEGHKKKCHQYWPDSTSKYCNL-RVTLRKTEV------FADyiIRTFVMSQVGQTE-------ERYVYQYHFTVWPDKGV
 .| .. | . ...| |....|...||| .|. |   .  .. | |..  .|      |.|   ..|.. .|  ..       .. |   .|. |||.| 
khwalieqynvaivvqlcsfvedeekkcaeyysdkvggelkfgrytvktvsvktdleeftd..kksfklytveiknekkkkkvkktvdilafsawpdhGa

PQYATAVLGLRRKItkDSLpgARPWVIHCSAGVGRTGAFLVIDAMLRQAKKQKTVDIFNYVKAIREDRPHMVQTSEQYVFIHLAV
|. | . | . .    .|    .  ..||||||||||... |   .   .|.|. |. . |. .|. |   ||. .| ... | |
pkeaytaldilkfc..esy..kknvlvhcsaGvGrtGtlvaikyGiqlcskkkvtdllsivlpvrqcryGavqdeqqliylllcv
subfamily_Sponge-PTP-7_pd Subfamily Sponge-PTP-7 180-242 1.7e-18 60.7 In-house 2-64 (69) alignment 
Range on Protein: 180-242
Range on HMM: 2-64/69.0
VIHCSAGVGRTGAFLVIDAMLRQAKKQKTVDIFNYVKAIREDRPHMVQTSEQYVFIHLAVLEA
|.|||.| ||||.|. |   . . | .| ||||| |. .|  || ||    .|.||| |. ||
vvhcssgtgrtgtfiaimvemarikseklvdifnnvqymrkcrpmmvmneieyifihdalvea
subfamily_Sponge-PTP7_pd Subfamily Sponge-PTP7 180-242 7.8e-18 58.6 In-house 1-63 (69) alignment 
Range on Protein: 180-242
Range on HMM: 1-63/69.0
VIHCSAGVGRTGAFLVIDAMLRQAKKQKTVDIFNYVKAIREDRPHMVQTSEQYVFIHLAVLEA
|.|||.| ||||.|. |   . . | .| ||||| |. .|  || ||   ..|.||| |. ||
vvhcssGtGrtGtfiaimvemarikseklvdifnnvqymrkcrpmmvmneneymfihdalvea
subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 13-239 3.7e-17 57.4 In-house 22-255 (290) alignment 
Range on Protein: 13-239
Range on HMM: 22-255/290.0
KNRYANIVtYDHSRVVLEKLSNDPHSDYINASYLRDYDGspKAYIATQGNICIN-------AGDFWRMMWQERRCVIVMLTGLIEGHKK----KCHQYWP
..|... .   ..||||.   .   .||| |...   .|   . |.||   . .         .|| |. ||.   .|||    | ...     | .| |
dqRlevpL.veatrvvLkgygkrfnddyiHAnrvtcpng..lrliltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCakYvp

DSTS---KYCNLRVTLRKTEVFADYIIRTFVMsQVGQTEERYVYQYHFTVWPDKGVPQYATAVLGLRRKITKDSlpgaRPWVIHCSAGVGRTGAFLVIDA
.|     |. .| |   . |   | ..|. |. . .. ||  |  . .  | .  |..    .| | .|. .       | ..||  |. |  |.  |. 
esvgeelkfkgltvkCkskekeddvetRelvv.kfddeeeftvtHsllkgWnklnvqedtktllsliqkvkask....tpvivHcvdGiSrsAalaaiil

MLRQ-AKKQKTVDIFNYVKAIREDRPHMVQTSEQYVFIHLAV
     |.... | . . .||.|. | ..... ... |.  ..
gyQkiaetsgsvkledvlkalrkqralaitsalelafvdagi
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 164-241 2.6e-15 51.1 In-house 216-293 (297) alignment 
Range on Protein: 164-241
Range on HMM: 216-293/297.0
LRRKITKDSLPGARPWVIHCSAGVGRTGAFLVIDAMLRQAKKQKTVDIFNYVKAIREDRPHMVQTSEQYVFIHLAVLE
|. .  .   |   . ..||||||||.|  .  |..| . .|..  |.   .. .|| |. .||| ||. ... |||.
lqleslraemprnayllvhcsaGvGrsGvvvlsdvilaklrkkripdvaailsilreqrarlvqtleqfellydavlk
subfamily_CG42327_pd Subfamily CG42327 178-237 4e-15 50.3 In-house 249-309 (319) alignment 
Range on Protein: 178-237
Range on HMM: 249-309/319.0
PWVIHCSAGVGRTGAFLVIDAMLRQAKKQ-KTVDIFNYVKAIREDRPHMVQTSEQYVFIHL
| |.||| ||||||  .  |  .|. ..  ..||| . |  .|.|| . |.| ||| ||. 
PlvvhcsdGvGrtGlviasdiairsleeskrsvdiPqlvssvrrdrasavltkeqyefiyk
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 11-120 5.7e-14 46.2 In-house 49-171 (349) alignment 
Range on Protein: 11-120
Range on HMM: 49-171/349.0
KAKNRYANIVTYDHSRVVLEKLSNDPH--------------SDYINASYLRDYDGSP-KAYIATQGNICINAGDFWRMMWQERRCVIVMLTGLIEGHKKK
 ||||| .|. |.||||.|.|  . ..               ||||| ||.    |. | |||||  .     ||....  ..  ... |.   |   .|
faknrykdilPyehsrvklkkslksskvikastsesdsgklddyinanylkltrisvekkyiatqaPlPstvddfykvillngvklvlsLnddkelslek

CHQYWPDstSKYCNLRVTLRKTEVF
|..|| .   .| | .| |. .  .
cdiywqe..lsysnitvklqnssly
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 1-48 1.4e-12 41.7 In-house 38-85 (440) alignment 
Range on Protein: 1-48
Range on HMM: 38-85/440.0
PSEAAKKRVNKAKNRYANIVTYDHSRVVLEKLSNDPHSDYINASYLRD
||. |    || |||| ||..||||||.||..   |.||||||||.  
psdiaslpnnkvknryrnilaydhsrvmleevkgvpdsdyinasying
subfamily_eak_pd Subfamily eak 6-164 2.4e-12 40.9 In-house 47-203 (332) alignment 
Range on Protein: 6-164
Range on HMM: 47-203/332.0
KKRVNKAKNRYANIVTYDHSRVVLEKLSNDPhSDYINASyLRDYDGSPKAYIATQGNICINAGDFWRMMWQERRCVIVMLTGLIEGHKKKCHQYWPDST-
 .|... .    .|| ||.  | |     ..   ||||| | ..    . || |      .   ||.|. ...   ||.|   .| . .|  .|.|| | 
tarleavnrnvvkivpydrylvrltssqlnr.lGyinas.laefsevGrkyiltGiasedkvfafwqmvleqkspaivqlledvelkleksdkyfpdktr

--SKYCNLRVTLRKTeVFA-DYIIRTFVMSQvGQtEERYVYQYHFTVWPDKGVPQYATaVLGL
   |.  | |. ..  |    .  | ...|. |  |   |. |..  | .  .|.|    | |
eelkfGildverkef.vkrniletrllelsk.Gn.ethrvlhykvfGwtettlpkyed.flal
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 141-239 3.6e-12 40.7 In-house 217-340 (350) alignment 
Range on Protein: 141-239
Range on HMM: 217-340/350.0
VYQYHFTVWPDKG---VPQYATAVLGLRRKITKDSL-------PGARPWVIHCSAGVGRTGAFLVIDAMLR----------QAK----KQKTVD-IFNYV
||| ..  |.| .    |.    .|  . ..  |           . | ..|||||||||| .. .| .|           . .     .|| | |.  |
vyqlqvknWkDlslllnPesilqalevkndliddlfaeshldnarsspilvhCsaGvGrtGtlvtlDsllsdfeilenltkesrkldvaaktrDlisiiv

KAIREDRPHMVQTSEQYVFIHLAV
. .|. |  |||. .|..||. |.
nelrkqrismvqnldqfifiYeal
subfamily_Sponge-PTP-2_pd Subfamily Sponge-PTP-2 6-158 1.3e-09 31.2 In-house 23-158 (169) alignment 
Range on Protein: 6-158
Range on HMM: 23-158/169.0
KKRVNKAKNRYANIVTYDHSRVVLEKLSNDPHSDYINAsylrdydgspkayiatqgnicinagdfwRMMWQERRCVIVMLTGLIEGH----KKKCHQYWP
.  .|..||| |  ..  | || |... .|  ||||||                            ||.|.    |||.| .  .      .|. .|  |
eltcnetknrpagplapshtrvklqrvmedlgsdyina............................rmiwetnasvivvlgdtddknnfwpekedyqlhp

DST--SKYC-NLRVTLRKTEVFADYIIRTFVMSQVGQTEERYVY----QYHFTVWPDKGVPQYA
       |   | |   | .. .. .   | .| | .  .. |      .|...||..||||  
avilgewytdslyvrtdkvhantsgveglfevsmvihsydddvteklsllhystwpqngvpqsp
subfamily_Sponge-PTP2_pd Subfamily Sponge-PTP2 6-157 2.6e-09 30.1 In-house 22-156 (169) alignment 
Range on Protein: 6-157
Range on HMM: 22-156/169.0
KKRVNKAKNRYANIVTYDHSRVVLEKLSNDPHSDYINAsylrdydgspkayiatqgnicinagdfwRMMWQERRCVIVMLTGLieghkKKCHQYWPDSTS
.  .|..||| |  ..  | || |... .|  ||||||                            ||.|.    |||.| .          ..||.   
eltcnetknrpagplapshtrvklqrvmedlgsdyina............................rmiwetnasvivvlGdt.....ddknnfwpeked

KYCNLRVTL------------RKTEVFADYIIRTFVMSQVGQTEERYVYQ----YHFTVWPDKGVPQY
      | |             | .  .  .   | .| | .  .. | .    .|...||..|||| 
yqlhpavilGewytdslyvrtdkvhpntsgveglfevslvihsydddvteqlsllhystwpqngvpqs
subfamily_Sponge-PTP-4_pd Subfamily Sponge-PTP-4 22-120 3.5e-09 31.0 In-house 5-92 (130) alignment 
Range on Protein: 22-120
Range on HMM: 5-92/130.0
YDHSRVVleklsndpHSDYINASYLRdYDGSPKAYIATQGNICINAGDFWRMMWqERRCVIVMLTGLIEGHkkkcHQYWPDSTSK-YCNLRVTLR--KTE
.. ||.           .|||||..    |  . |. ||  .. .. |||.||  ||   .... | .|       .|||||    . . ....   . .
fevsrlq........gntyinasfvG.llgrtaeylltqhpladtsmdfwkmml.eryvnvlvvlgsveee....deywpdsePlewyeediivtltdrd

VF
 |
ef
subfamily_Sponge-PTP3_pd Subfamily Sponge-PTP3 7-61 1.6e-08 28.6 In-house 45-95 (95) alignment 
Range on Protein: 7-61
Range on HMM: 45-95/95.0
KRVNKAKNRYANIVTYDHSRVVLEklsNDPHSDYINASYLRDYDgSPKAYIATQG
   |  |||. ||. || .||||        |||||| ..  |    ..|||.||
seanipknrflnifpydatrvvlt...tkrdsdyinacfvdgya.rkncyiaaqg
subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 10-83 2.6e-08 27.8 In-house 37-114 (347) alignment 
Range on Protein: 10-83
Range on HMM: 37-114/347.0
NKAKNRYANIVTYDHSRVVLE-----KLSNDPHSDYINASYLRdYDGSPKAYIATQGNICINAGDFWRMMWQERRCVIV
. .|||  .    | .||||      .   |.   |||||... .| . | || ||  .     |||.|.   .   .|
slsknrskdvklidatrvvlspeksknsraddvetyinashik.fdnaskeyiltqyplpdtvrdfwkmvsvtkvtqvv
subfamily_eak_pd Subfamily eak 176-241 4.1e-08 27.0 In-house 236-303 (332) alignment 
Range on Protein: 176-241
Range on HMM: 236-303/332.0
ARPWVIHCSAGVGRTGAFLVIDAMLR--QAKKQKTVDIFNYVKAIREDRPHMVQTSEQYVFIHLAVLE
.   .| .. |  |.|.|.||| ..|  ..||. .  . ...  ... | | | .. |. ||. .||.
sfapiiqsarGsaraGvfvvidllirlidnkkknlysvedlilkvkskrihsvlvalqhsfiyeivld
subfamily_PTPDC1_pd Subfamily PTPDC1 138-235 5.1e-08 27.6 In-house 80-168 (182) alignment 
Range on Protein: 138-235
Range on HMM: 80-168/182.0
ERYVYQYHFTvWPDKGVPQYaTAVLGLRrKITKDSLPGArPWVIHCSAGVGRTGafLVIDAMLRQAKKQKTVdifNYVKAIREDRPHMVQTSEQYVFI
|. .| | |. |.| ||.   . .| .  |. . .|       .|| || ||||  ..| ..|  ||. ..    . .| .|. ||. .|| ||  ..
eqgiyvynfg.wkDygvasl.eriLdiv.kvvafalqeg.kvavhChaGlGrtG..vliacylvyakrltae...kaiklvrskrpksiqtreqvelv
subfamily_Cele-PTP-12_pd Subfamily Cele-PTP-12 9-94 1e-07 25.8 In-house 33-115 (332) alignment 
Range on Protein: 9-94
Range on HMM: 33-115/332.0
VNKAKNRYANIVTYDHSRVVLEklSNDPHSDYINASYLRDYDGsPKAYIATQGNICINAG-DFWRMMwQERRCVIVMLTGLIEGHKK
 |   ||   .  .||||| |    .| . |. |||..  |     ||| .|  .   .   ||||.  ||.  .... | |. ..|
nnmdmnriphlycfdhsrvela..pqdgkddfynaswvdgysk.ksayifaqapfndhteyvfwrmv.serkpsmilvfgdidekqk
subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 96-235 2.6e-07 24.5 In-house 175-330 (347) alignment 
Range on Protein: 96-235
Range on HMM: 175-330/347.0
CHQ--YWPDSTSKYCNLRVTLRKTE-VFADYIIRTFV------MSQVGQTEERYVYQYHFTVWPDKGVPQYATAVLGLRRKITKDSLPG-------ARPW
 |.  ..| .| .| ||.  | .|  |  |   ....      .   | .|  .   |  | || |  |.    || | |   |.| .          | 
lhrssffpletdhylnlkgwlintravevdqrnknwmnkytvevvaegcseatfakvyncttwpwkkypddekkvlalvrapvkesstslianleklapv

VIHCSAGVGRTGAFLVIDAMLRQAKKQKTVDIFNYVKAIREDRPHMVQTSEQYVFI
|. |  |. |. . ..   .. |  . || |  .  | .|..|  .   |  | . 
vvmcdlgldrsatvvltsiiieqvldgktpdcddlfkkmrdqragvftmsifytya
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 177-240 3.5e-07 23.9 In-house 266-341 (349) alignment 
Range on Protein: 177-240
Range on HMM: 266-341/349.0
RPWVIHCSAGVGRTGAFLVIDAMLR--QAK---------KQKTVD-IFNYVKAIREDRPHMVQTSEQYVFIHLAVL
 . ..||||| |||| .  .| .|   .           .... | |.  |  .|  |  |||   |...|. |.|
stllvhcsaGcGrtGvlvtldlllsileplqnesnkiklqallkDlisiivnelrkqrismvqnlaqfiaiyealL
subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 8-47 1.1e-06 22.5 In-house 37-75 (244) alignment 
Range on Protein: 8-47
Range on HMM: 37-75/244.0
RVNKAKNRYANIVTYDHSRVVLEKlSNDPHSDYINASYLR
 .| .|||| ||. .|..||.|   |.   ||||||.|..
sanatknryinilpfdetrvilss.skkegsdyinanyiq
0038934 (Phosphotyrosine protein) phosphatases II 141-233 1.6e-06 23.4 In-house 79-167 (194) alignment 
Range on Protein: 141-233
Range on HMM: 79-167/194.0
VYQYHFTVWPDKG-VPQYATAVLGLRRKITKDSLPGARPWVIHCSAGVGRTGAFLVIDAMLRqaKKQKTVDIFNYVKAIRedrPHMVQTSEQYV
 ..|.   .||.| ||....    |.   .. .       ..|| ||.|||| ...   . |   . .  .  .... .|   |..... ... 
gieylklpfpddgtvPsleillrfldlvdeflnedpggvvaVHCkaGlgRtGtlvaaYLiyr..lgmsaeeAialfrekR...pgaipnqdyle