Gene NvecPTP-sf2-2 in Nematostella vectensis

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily NvecPTP-sf2
Protein sequence
ID Type Fasta BLAST phosphatome Note
NvecP045_AA protein Get Run
NvecP045_AA_1-242 phosphatase_domain Get Run
NvecP045_AA_254-532 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_PTPRD_pd Subfamily PTPRD 2-427 8.5e-218 719.5 In-house 42-466 (564) alignment 
Range on Protein: 2-427
Range on HMM: 42-466/564.0
AARKPANKNKNRYANIVAYDHSRVVLERVNGDEDSDYINASFIHGYDgTPRSFIASQGPLPPAFEGFWRMVWEQNSQSIVMLTNLVELGKTKCHKYWPDK
||.|||||.|||||||||||||||||..|.|||.|||||||||.||. .....||.||||....| ||||||||||..|||||.|.| ||.|||||||.|
aankpaNkaKNRyanivaYdhsRVvLskvegdegsDYINAsfidgyr.krkayIAtqgPlaetiedFWRmvweqnsstiVmltkleEkgkvkchkYWPek

-TETYGGVTVTLHQSEIFADYEIRTFILSKAKRSGSRMVRQFHFTVWPDKGVPQYATAVLAFRRKVRALNPRDAGPVIVHCSAGVGRTGAYIVIDAMLEQ
 |||||..||||...| .||||||||.|.|.|.| ||.||||||| |||.|||..||..|...|||||||..||||..|||||||||||..||||||||.
gtetygeltVtleeeeeladyeirtfklkkkkssesreVrqFhFtsWPdhgvpesatslLdlirkvralnepdagPivVhCSaGVGRTGtfividamler

AKKSRTVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVLEALTCGNTEIQSENYNQAMQKLASVNRKFQMTGYALEFQRLNsvTSREIPAEEKSVGEKPQN
.|...||||..|..||||.|..||||.|||.|||.|.||||.|||||..|||..|..||||.|.....|||..||||||.  |..||..||..|..||.|
ikeektvDiyqyvkalrkqRnamVqteeQYiFiheailealacgntevesenlkqhlqkLaeveedtemtgleleFqrLa..takeieleefavatkpkn

LHKNRFSDIIALNSCRVMLHKEHADEESDYINAVFLHVRMERNAFIATQHPLQHTIEDFWRMVTDYDIGTIVMLNNLHE-HDQEYPQYLPVEGATKYGHI
..|||||.|.||.||||.|....|.||||||||..|.   |..||||||.||..|.|||||||.......||||..|.|  ..|. .| .  .|||||.|
kkknrfsnilalescrvvlsairakeesdyinasyleayrekrafiatqaplkntvedfwrmvweeevkiivmltkleekleeesseyysdleatkyGei

RVSLLSKQEKGDVISTKLKVTRNKKTHE
 ...|.|.||.|.. .| ||....|...
tikvlkkkeksdilfrkkkvevkeksea
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 244-538 4.6e-144 474.2 In-house 1-297 (298) alignment 
Range on Protein: 244-538
Range on HMM: 1-297/298.0
GNTEIQSENYNQAMQKLASVNRKFQMTGYALEFQRLNSVTSrEIPAEEKSVGEKPQNLHKNRFSDIIALNSCRVMLHKEHADEESDYINAVFLHVRMERN
|||||..|....|.||||.|..|...|||||||||||||.| ||..|||.|..||.| .|||..|||||.|.||.|.||.||||||||||.|||   .||
gnteieaedlkaalqklaavkkkkkltgyalefqrlnsvss.eieeeekevarkpenkkkNRyadiialdssRvvLekedadeesdYiNAsflhaykgrn

AFIATQHPLQHTIEDFWRMVTDYDIGTIVMLNNLHEHDQ-EYPQYLPVEGATKYGHIRVSLLSKQEKGDVISTKLKVTRNK--KTHEVRHLHHVSWPDKC
||||||.||..|.||||||||..||||||||.||.|.|. .|..| | ||...||.|.||||||.|..|.|..||||...|  |..|||.||..|||||.
afiatqaPltetvedFWrmvteedigtiVmltnleeldktkyhkywPdegketygeitvsllskeefadlivrklkvskkkeekerevrqlhftsWpdkg

IPEVARSVLDLLDEVQASQQQCGNAPVLVQCSNGVGRSGTFCAISSVIERLKTEQVIDVFQVIKRIRANRPGAVESLTQYVFCYQIIQKYLDSFSDYA
.||.|.||||||..|.|||||.||.||.||||.||||||||.||.||.||.|.|||.|||||.|..|..|||||.. .||||.|......||||.|..
vpenatsvldllrkvrasqqqagnkpvivqCsaGvgRsGtfiaidsvlervkkeqvvDvfqvvkvlRkkrpgavqteeqYvfiyeavlealdsfndei
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 292-539 1e-134 442.4 In-house 1-250 (250) alignment 
Range on Protein: 292-539
Range on HMM: 1-250/250.0
KSVGEKPQNLHKNRFSDIIALNSCRVMLHKEHADEESDYINAVFLHVRMERNAFIATQHPLQHTIEDFWRMVTDYDIGTIVMLNNLHEHDQEYPQYLPVE
|||..||||..|||..|||||.|.||.|.||..|.|||||||.|||...||.||||||.|||.|||||||||.....||||||.||.|....|.||.|||
ksvakkpqnkeknryadiialdssrvvLekekgdkesdyinasflhgyderkafiatqgPlqatiedfWrmvleeksgtivmLtnLkesektyhqywPve

GATKYGHIRVSLLSKQEKGDVISTKLKVTRNKKTHE--VRHLHHVSWPDKCIPEVARSVLDLLDEVQASQQQCGNAPVLVQCSNGVGRSGTFCAISSVIE
.|.|||...||||||.|..|....|||....||..|  ||.||.|.||||..||||..||.||..|||||||.|||||.||||.||||||.|.||..|.|
kaekyGdvtvsllskeefadytkrklklskakkaderivrqlhfvvWPdkgvPevatavLellkkvqasqqqagnaPvivqCsaGvgrsGafiaidavle

RLKTEQVIDVFQVIKRIRANRPGAVESLTQYVFCYQIIQKYLDSFSDYAN
|||.|.|.|||.|||..|..||.|||||.||||.|.||.|.|||..|||.
rlkkekvvdvfkvikvlrkdrphavesleqyvfvyeiilkaldsvedyar
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 1-249 3.5e-128 422.0 In-house 49-298 (298) alignment 
Range on Protein: 1-249
Range on HMM: 49-298/298.0
EAARKPANKNKNRYANIVAYDHSRVVLERVNGDEDSDYINASFIHGYDGTPrSFIASQGPLPPAFEGFWRMVWEQNSQSIVMLTNLVELGKTKCHKYWPD
|.||||.||.|||||.|.|.|.||||||....||.||||||||.|.|.|.. .|||.|.||....|.|||||.|.....|||||||.||.|||.||||||
evarkpenkkkNRyadiialdssRvvLekedadeesdYiNAsflhaykgrn.afiatqaPltetvedFWrmvteedigtiVmltnleeldktkyhkywPd

-KTETYGGVTVTLHQSEIFADYEIRTFILSKAKRSGSRMVRQFHFTVWPDKGVPQYATAVLAFRRKVRAlNPRDAG--PVIVHCSAGVGRTGAYIVIDAM
 ..|||| .||.|...| |||...|....||.|....|.|||.|||.|||||||..||.||...||||| ....||  ||||.|||||||.|..|.||..
egketygeitvsllskeefadlivrklkvskkkeekerevrqlhftsWpdkgvpenatsvldllrkvra.sqqqagnkpvivqCsaGvgRsGtfiaidsv

LEQAKKSRTVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVLEALTCGNTEIQ
||..||...||.......|||.||..|||.|||.||..||||||...|.||.
lervkkeqvvDvfqvvkvlRkkrpgavqteeqYvfiyeavlealdsfndeie
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 2-254 3.7e-126 414.4 In-house 3-249 (250) alignment 
Range on Protein: 2-254
Range on HMM: 3-249/250.0
AARKPANKNKNRYANIVAYDHSRVVLERVNGDEDSDYINASFIHGYDGTpRSFIASQGPLPPAFEGFWRMVWEQNSQSIVMLTNLVELGKTkCHKYWP-D
 |.||.||.|||||.|.|.|.||||||...||..||||||||.||||.. ..|||.||||....|.|||||.|..|..|||||||.| .|| .|.||| .
vakkpqnkeknryadiialdssrvvLekekgdkesdyinasflhgyder.kafiatqgPlqatiedfWrmvleeksgtivmLtnLkesekt.yhqywPve

KTETYGGVTVTLHQSEIFADYEIRTFILSKAKRSGSRMVRQFHFTVWPDKGVPQYATAVLAFRRKVRALNPR-DAGPVIVHCSAGVGRTGAYIVIDAMLE
|.|.||.|||.|...|.||||..|...|||||....|.|||.||.||||||||..|||||....||.| ... ...||||.|||||||.||.|.|||.||
kaekyGdvtvsllskeefadytkrklklskakkaderivrqlhfvvWPdkgvPevatavLellkkvqasqqqagnaPvivqCsaGvgrsGafiaidavle

QAKKSRTVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVLEALTCgnteiqSENYN
..||...||.......|||||||.|...|||.|.....|.||..      .|.|.
rlkkekvvdvfkvikvlrkdrphavesleqyvfvyeiilkalds......vedya
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 4-279 3.1e-109 359.9 In-house 42-318 (318) alignment 
Range on Protein: 4-279
Range on HMM: 42-318/318.0
RKPANKNKNRYANIVAYDHSRVVLERVNGDEDSDYINASFIHGYDgTPRSFIASQGPLPPAFEGFWRMVWEQNSQSIVMLTNLVELGKTKCHKYWPDK-T
 .|.||.|||||||.||||.|| |. ..|.|.||||||..| ||    ...||.|.||| ..| ||||||||||. |||||...| ||.|.|.|||.| .
lepvnkaknryanilaydhtrvkLqmlegeegsDyinanyidGyr.rkkayiaaqaPlpetieDfWrmvWeqnsavivmltqeeergkakvhryWPskgs

ETYGGVTVTLHQSEIFADYEIRTFILSKAKRSGSRMVRQFHFTVWPDKGVPQYATAVLAFRRKVRALN-PRDAGPVIVHCSAGVGRTGAYIVIDAMLEQA
..|| ..|.|...  ..|| .|.| ... . . ||.|||.|.| |||.|||. .. .|.. |.|.. . . .|||..||||||||||| .|..|..||..
rsygklvvelkeevelsdyvlrefkvtrteeeesrqvrqyhytsWpdegvpesgaslldlvrqvskaqqksgagpivvhCsaGvGrtGvfiavdilleri

KKSRTVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVLEALTCGNTEIQSENYNQAMQKLASVNRKFQMTGYALEFQRL
|.  .||. ..   ||. |. ||||..|| ||. ..||||..|.||..... .. ...|  .. .  .|   .|||||
kaealvDvfqtvkqlreqrnlmvqtedqyefiydvllealasgdtevdasdlrsrirelreqdpesgttemdaefqrl
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 1-239 5.3e-104 341.6 In-house 1-239 (239) alignment 
Range on Protein: 1-239
Range on HMM: 1-239/239.0
EAARKPANKNKNRYANIVAYDHSRVVLERVNGDEDSDYINASFIHGYDGTPRSFIASQGPLPPAFEGFWRMVWEQNSQSIVMLTNLVELGKTKCHKYWPD
|||.|  || ||||||||.|||||||||... |  |||||||... |||.|...||.|| . ..   ||||.|..    ||||| |.|  | |||.||||
eaakkrvnkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpd

KTETYGGVTVTLHQSEIFADYEIRTFILSKAKRSGSRMVRQFHFTVWPDKGVPQYATAVLAFRRKVRALNPRDAGPVIVHCSAGVGRTGAYIVIDAMLEQ
 |  |  . |||...|.|||| ||||..|.  ..  | | |.|||||||||||||||||| .|||.   .   | | ..|||||||||||..|||||| |
stskycnlrvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcsagvgrtgaflvidamlrq

AKKSRTVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVLE
||| .|||| ||. |.|.|||||||| ||| ||| ||||
akkqktvdifnyvkairedrphmvqtseqyvfihlavle
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 2-240 5.5e-104 341.5 In-house 1-239 (239) alignment 
Range on Protein: 2-240
Range on HMM: 1-239/239.0
AARKPANKNKNRYANIVAYDHSRVVLERVNGDEDSDYINASFIHGYDGTPRSFIASQGPLPPAFEGFWRMVWEQNSQSIVMLTNLVELGKTKCHKYWPDK
||.|  || ||||||||.|||||||||... |  |||||||... |||.|...||.|| . ..   ||||.|..    ||||| |.|  | |||.|||| 
aakkrvnkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpds

TETYGGVTVTLHQSEIFADYEIRTFILSKAKRSGSRMVRQFHFTVWPDKGVPQYATAVLAFRRKVRALNPRDAGPVIVHCSAGVGRTGAYIVIDAMLEQA
|  |  . |||...|.|||| ||||..|.  ..  | | |.|||||||||||||||||| .|||.   .   | | ..|||||||||||..|||||| ||
tskycnlrvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcsagvgrtgaflvidamlrqa

KKSRTVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVLEA
|| .|||| ||. |.|.|||||||| ||| ||| |||||
kkqktvdifnyvkairedrphmvqtseqyvfihlavlea
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 2-277 5.1e-101 332.9 In-house 42-319 (319) alignment 
Range on Protein: 2-277
Range on HMM: 42-319/319.0
AARKPANKNKNRYANIVAYDHSRVVLERVNGDEDSDYINASFIHGYDGTpRSFIASQGPLPPAFEGFWRMVWEQNSQSIVMLTNLVELGKTKCHKYWPDK
 | |. ||.|||| ||.|||..||||  ..| |.||||||||| ||.   . ||| |.||  ..| |||||||..|  .||||.||| .| |..||||..
saskeenkkknryqnilaydrtrvvlseldgvegsdyinasfidgyqer.ekfiatqaPlentiedfWrmvWeeessivvmltklveklkvklkkywpee

T-ETYGGVTVTLHQSEIFADYEIRTFILSKAKRSG-SRMVRQFHFTVWPDKGVPQYATAVLAFRRKVRALNPR-DAGPVIVHCSAGVGRTGAYIVIDAML
. |.|| ..||| . |  .||.|| . | |..    .|.| .|..| |||..||..||..|.. ...|    . ..||..|||||||||||..||.||||
nfeeyGrlivtleeeeeledyiirklklnkkssevetRevkhfqyteWpdhdvPekatslldllkrirksrektqsgPivvhCsaGvGRtGtfivldaml

EQAKKSRTVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVLEALTCGNTEIQSENYNQAMQKLASVNRKFQMTGYALEFQ
|. |.  ..|. ..   ||  |. |||..|||.||. |.|||...|.|||. .. .. ...||. . .  .|| . |||
ervkeegvlDvfstvsrlRtqRnimvqrpeqYkfiyealleaveagdteievqdlrdrlkqlaekvadtgetglerefq
0050432 (Phosphotyrosine protein) phosphatases II 2-245 5.2e-96 316.9 In-house 62-303 (308) alignment 
Range on Protein: 2-245
Range on HMM: 62-303/308.0
AARKPANKNKNRYANIVAYDHSRVVLervngDEDSDYINASFIHGYD-GTPRSFIASQGPLPPAFEGFWRMVWEQNSQSIVMLTNLVELGKTKCHKYWPD
.|..|.||.|||| .|..||||||.|     ||.|||||||...||. . || ||| |||||  .| |||||||||.. |||||.||| |. ||..|||.
vallpenkdkNrykdilpydhsRVkl.....degsdYInAsyvdgyssklprkfIatqgPlpntvedFwrmvweqnvrvIvmLtklvengrekcaqYwpl

----KTETYGGVTVTLHQSEIFADYEIRTFILSKAKRSGSRMVRQFHFTVWPDKGVPQYATAVLAFRRKVRALNprDAGPVIVHCSAGVGRTGAYIVIDA
    ....||..||||   |...|| .||..|.. . . ||.|..||.| ||| |||......|.| ..||  .  . ||..|||||||||||..|..| 
elgggsleygkftvtllseevlddytvrtleltnlgdgesrtvthfhytnWpdhgvPpspeilldflelvrksl..pggpivVHCsaGvGRtGtfialdl

MLEQAKKSRTVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVLEALTCGN
.||| .| ..||. ...  ||. ||.||||.||| |.. |.|| | .  
lleqlekeggvdvfeavkklReqRpgmvqtpeqylflyralleylklkl
subfamily_PTPRG_pd Subfamily PTPRG 2-255 5.3e-96 317.0 In-house 41-301 (563) alignment 
Range on Protein: 2-255
Range on HMM: 41-301/563.0
AARKPANKNKNRYANIVAYDHSRVVLERVNGDEDS-DYINASFIHGYDgTPRSFIASQGPLPPAFEGFWRMVWEQNSQSIVMLTNLVELGKTKCHKYWP-
...|| ||.|||| ||||||.||| |. . | ... |||||..|.||    . |||.||||.  |. ||||.||||.. |||.||||| |. ||. ||| 
hsqkpenkrKnRylnivaydrsRvklsplpgkkkklDYinAnyidGyq.kskafiatqgplkdtfddFWrmiWeqnvaiivmitnlvergrrkcdvYWPk

DKTETYGGVTVTLHQSEIFADYEIRTFILSK--AK----RSGSRMVRQFHFTVWPDKGVPQYATAVLAFRRKVRALNPRDAGPVIVHCSAGVGRTGAYIV
|..|||| ..||| ..|..| | .||... .   |    .   ..|||.|.| |||.|||.... || | .|  | |...|||..||||||||||| |||
desetygalqvtlieeevlalytvrtlviknlklkkkkqcdteklvrqyhytkWPdhgvPehslpvLifvkkssaankaeaGPivvHcsaGvgrtGtyiv

IDAMLEQAKKSRTVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVLEALTCGNTEIQSENYNQ
.|..|.| ..  .|.. . |  .|  |...|||.||| |.| |.|||.. ..||...|. ..
ldtllkqiqqenavnvfgflkhiraqRnflvqteEqYiflhdalleaiasketellaeqvee
subfamily_PTPRA_pd Subfamily PTPRA 1-275 6.6e-96 316.0 In-house 51-329 (330) alignment 
Range on Protein: 1-275
Range on HMM: 51-329/330.0
EAARKPANKNKNRYANIVAYDHSRVVLERVNGDEDSDYINASFIHGYDGTpRSFIASQGPLPPAFEGFWRMVWEQNSQSIVMLTNLVELGKTKCHKYWPD
|.| |  ||.|||. ||. ||.|||.|  ..| |.|||||||||.||     .|||.|||.  . | ||||.|||.|..|||||.| |  ..||..||||
elaskeenkeknrvvnilPydfsrvilsvkeGveesdyinasfidGykek.dkfiaaqGPkeetvedfwrmiweqksativmltelkerkeekcaqywPd

K-TETYGGVTVTLHQSEIFADYEIRTFILS----KAKRSGSRMVRQFHFTVWPDKGVPQYATAVLAFRRKVRALNPRDAGPVIVHCSAGVGRTGAYIVID
. . ||| ..|.......  || .| |..     ....  ||.||||||| ||| |||  .  .| . .||..||.. |||..|||||||||||..||.|
eGlvtyGnirvevedetvlvdytvrkflvqqlpdatrekksrlvrqfhftswPdvGvPfepiGmlkllkkvkklnqqsagpivvhcsaGvGrtGtfivld

AMLEQAKKSRTVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVLEALTCGNTEIQSENYNQAMQKLASVNRKFQMTGYALE
|.||. |  | ||. . .  ||. ||.||||.||| ||. ..||    |.||..    .. .||| .   ... .|   |
avlervkaerkvdvfefvkrlrlqrpqmvqtdeqyefiykvlleyylygdteldvsslekhlqklynkitgtdkigleee
subfamily_PTPRB_pd Subfamily PTPRB 2-244 5.3e-95 312.8 In-house 45-288 (293) alignment 
Range on Protein: 2-244
Range on HMM: 45-288/293.0
AARKPANKNKNRYANIVAYDHSRVVLERVNGDEDSDYINASFIHGYDgTPRSFIASQGPLPPAFEGFWRMVWEQNSQSIVMLTNLVELGKTKCHKYWPDK
||....|..|||| ||..|||||| |. ......||||||..|.||  .|| |||.||||| ... |||||||..|. |||||.||| ||.||..|||..
aaelavnraknrytnilpydhsrvkLaalkdesgsDYinanyipgyn.sprefiatqGPlpetvddfWrmvwekkssiivmltqlvekgkvkCeeYWPad

--TETYGGVTVTLHQSEIFADYEIRTFILSKakRSGSRMVRQFHFTVWPDKGVPQYATAVLAFRRKVRALN--PRDAGPVIVHCSAGVGRTGAYIVIDAM
  . .|| ..||| ..|   |. ||.. ..|  .. .| |||.||| ||| |||. ....|.| |.||       ...|..|||||||||||..| .| .
eepvlyGdikvtlvaeeeledwvirelkiek..ekeerkvrqyhftsWpdhgvPektktlldfvrtvreaiektaskrPivvhCsaGvGRtGtfialdrl

LEQAKKSRTVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVLEALTCG
|.. ... .|||   ...||..| ..|||..|| |||..||. |. .
lqaieeedyvdifgivaelReeRnllvqtekqYifihqcvldllrkk
subfamily_PTPRK_pd Subfamily PTPRK 2-260 9.5e-95 312.0 In-house 37-296 (314) alignment 
Range on Protein: 2-260
Range on HMM: 37-296/314.0
AARKPANKNKNRYANIVAYDHSRVVLERVNGDEDSDYINASFIHGYDgTPRSFIASQGPLPPAFEGFWRMVWEQNSQSIVMLTNLVELGKTKCHKYWPDK
||.|  |..|||. .|.|||.|||.|  ..|| .||||||..| .|   |. ||. ||||.   . |||.|...|. ||||||.||| |. || ||||..
aakkdenreknrsgdilaydrsrvflitidgdpssdyinaalidsyk.rpaafivtqgPlqetvkdfWrlvydencasivmltelvevgrvkClkyWPed

TETYGGVTVTLHQSEIFADYEIRTFILSKA--KRSGSRMVRQFHFTVWPDKGVPQYATAVLAFRRKVRALNPRDAGPVIVHCSAGVGRTGAYIVIDAMLE
||.|| . |.| ..|. |.. .|.| ..|.  . .. |.||||.|. ||| .||..||..|.. |.| . .. .||...|||||| ||||..|.|| .|.
tevygdikvelvetellaelvvrifrveklargqeeirevrqfqflgWpdhdvPvsatgllklvrrvkksqeeeaGrivvhCsaGaGrtGtfiaidivld

QAKKSRTVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVLEALTCGNTEIQSENYNQAMQKL
 ... ..||. |   .||. .. ||.|.||| ||. ..|||  ||.| |   ... .  . 
mieregvvdvfnavktlrsrkvnmveteeqykfiydvileaclcgetaipvsefkalyles
0040438 (Phosphotyrosine protein) phosphatases II 3-259 1.4e-94 312.3 In-house 38-294 (317) alignment 
Range on Protein: 3-259
Range on HMM: 38-294/317.0
ARKPANKNKNRYANIVAYDHSRVVLERVNGDEDSDYINASFIHGYDGTPRsFIASQGPLPPAFEGFWRMVWEQNSQSIVMLTNLVELGKTKCHKYWP-DK
|..|.||.|||| .|. ||||||.|  ..||.||||||||...|.. ... ||| |||||  .| ||||||||....|||||.|.|||. ||..||| ..
aelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyvdgpnlkrk.fIatqgPlpntvedFwrmvweqgvtvivmLteleelgrekcaqYwplge

TETYGGVTVTLHQSEIFADYEIRTFILSKAKRSGSRMVRQFHFTVWPDKGVPQYATAVLAFRRKVRALNPRDAGPVIVHCSAGVGRTGAYIVIDAMLEQA
| |||..|||| . |  |....||. ... . | ||.|..||.| ||| |||.. . .|.| ..||. .... |||.|||||||||||..|... |||| 
tltygdftvtllseeelagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfleavrealedpggpvlVHCsaGvgRtGtfiaaylmleql

KKSRTVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVLEALTCGNTEIQSENYNQAMQK
.| ..||. . .  ||. ||..||| ||| |.. |.|| |....| .   ..  ...|
ekeggvdveeavkelreqRpgavqtpeqyrflydalleylkrkltlepaselklkllk
0051299 (Phosphotyrosine protein) phosphatases II 2-241 1.8e-94 311.7 In-house 43-286 (288) alignment 
Range on Protein: 2-241
Range on HMM: 43-286/288.0
AARKPANKNKNRYANIVAYDHSRVVLERVNGDEDSDYINASFIHGYDGTPRsFIASQGPLPPAFEGFWRMVWEQNSQSIVMLTNLVELGKTKCHKYWP-D
||..|.|..|||| .|..||||||.|  ..|.|.|||||||.|.||. . . ||| |||||  .| |||||||||.. |||||.|||||..||..||| .
aallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyidgynlkrk.fIatqgPlpntvedFWrmvweqnvrvIvmltklvelgrekcaqYwplg

KTETYGGVTVTLHQSEIFADYEIRTFILSKA----KRSGSRMVRQFHFTVWPDKGVPQYATAVLAFRRKVRALNPRDAGPVIVHCSAGVGRTGAYIVIDA
...||| .||||   |...|| .||.....     . . ||.|..||.| ||| |||......|.| |.||  .. . |||.|||||||||||..|..| 
gsltygditvtllseevlddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpdspellldflrlvrkalasgggpvvVHCsaGvgRtgtfialdl

MLEQAKKSRTVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVLEAL
.||| .| ..||. ...  ||. ||.|||| ||| |.. |.||.|
lleqlekeggvdvleavkrlreqRpgmvqtpeqyrfvyealleyl
0046845 (Phosphotyrosine protein) phosphatases II 2-246 2.5e-92 304.6 In-house 22-279 (284) alignment 
Range on Protein: 2-246
Range on HMM: 22-279/284.0
AARKPANKNKNRYANIVAYDHSRVVLERVNGD-EDSDYINASFIHGYD----GTPRSFIASQGPLPPAFEGFWRMVWEQNSQSIVMLTNLVELGKTKCHK
.|..|.|..|||| .|..||||||.| ...|| |||||||||...|||     ... ||| |||||  .| |||||||||.. |||||.||| |..||..
vallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweqnvrvIVmltelvengrekcaq

YWPDK--TETYGGVTVTLHQSEIFADYEIRTFILSKAK-RSGSRMVRQFHFTVWPDKGVPQYATAVLAFRRKVRALNP--RDAGPVIVHCSAGVGRTGAY
|||..  . |||..||||   |.. || .||. |.. .  . ||.|..||.| ||| |||.... .|.| |.|| |..   . ||..|||||||||||..
YwplegevltygdftvtllseevkddytvrtleltnlgytgesrtvthfhytswpdhgvppspedlleflrlvrellenlpgggpivVHCsaGvgRtGtf

IVIDAMLEQAKKSR---TVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVLEALTCGNT
|..| .||| .| .   .||. ...  ||. ||.|||| ||| |.. |.||.| ...|
ialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyealleylklklt
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 7-239 3.5e-91 299.7 In-house 2-237 (237) alignment 
Range on Protein: 7-239
Range on HMM: 2-237/237.0
ANKNKNRYANIVAYDHSRVVLERVNGDedSDYINASFIHGYDGTPRSFIASQGPLPPAFEGFWRMVWEQNSQSIVMLTNLVELGKTKCHKYWPD--KTET
 || ||||.||||||||||||.   ..  ||||||....|.||||...||.|||| .. . ||.|||...   ||||| |.|  . |||||||.  . ..
enkiknrygnivaydhsrvvlkgagsg..sdyinatylkgfdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywpstdqpaa

YGGVTVTLHQSEIFADYEIRTFILSKA-KRSGSRMVRQFHFTVWPDKGVPQYATAVLAFRRKVRALNPR--DAGPVIVHCSAGVGRTGAYIVIDAMLEQA
|| .||.|.. | |.|| .|...|||  .  . |.. |..||.|||.||||...|.| ||...   .|   ..|| |.|||||||||| ..|||||| ||
ygvltvslkkkeefsdytvrslllskrltlkevrlihqyqftswpdrgvpqqtaallrfrkniinrsphvsesgpwiihcsagvgrtgiflvidamlrqa

KKSRTVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVLE
|. . ||| ||. .. .|||...|||.|| ||| ..||
kekkvvdiynyvysieedrpyiiqtkdqyvfihqtile
0036941 (Phosphotyrosine protein) phosphatases II 2-249 4e-91 300.7 In-house 33-285 (297) alignment 
Range on Protein: 2-249
Range on HMM: 33-285/297.0
AARKPANKNKNRYANIVAYDHSRVVLervnGDEDSDYINASFIHGYDGTPRsFIASQGPLPPAFEGFWRMVWEQNSQSIVMLTNLVELGKTKCHKYWP--
.|..|.|..|||| .|..|||.||.|    .||.|||||||.. ||| . . ||| |||||  .| |||||||||...|||||.|||||. ||..|||  
vallpenleknRykdilpydhtRVkl....ddegsdYinAsyvdgydlkrk.fIatqgPlpntvedFWrmvweqnvtvIvmltelvelgrekcaqywple

-DKTETYGGVTVTLHQSEI--FADYEIRTFILSKAKRSGSRMVRQFHFTVWPDKGVPQYATAVLAFRRKVRALNPR--DAGPVIVHCSAGVGRTGAYIVI
 ... |||..||||   |.  ..|| .||. ... . . ||.|..||.| ||| |||.... .|.| ..||  ..   . |||.|||||||||.|..|..
egesltygdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfielvrkvlkllpsggpvlVHCsaGvgRsgtfiaa

DAMLEQAK---KSRTVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVLEALTCGNTEIQ
| ||.| .   | ..||| ...  ||. ||..||| ||| |.. |.|| | ...| ..
dlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallellkkkltkep
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 2-261 1.5e-90 298.3 In-house 43-299 (315) alignment 
Range on Protein: 2-261
Range on HMM: 43-299/315.0
AARKPANKNKNRYANIVAYDHSRVVLERVNGDEDSDYINASFIHGYDgTPRSFIASQGPLPPAFEGFWRMVWEQNSQSIVMLTNLVELGKTKCHKYWPDK
 |.|  ||.|||| ||.|||.||| |  .. |..|||.||.|| ||.  .| .||.|||.. . . |||.|.|..   |||||||||  | |. ||||||
vakkienkqknryiniiaydksrvqlpllendphsdyvnanfidGyn.kkrryiaaqgpnvasvkdfwrlvfeedigkivmltnlvegekrkaekywpdk

TETYGGVTVTLHQSEIFADYEIRTFilSKAKRSGSRMVRQFHFTVWPDKGVPQYATAVLAFRRKVRALNPRDAGPVIVHCSAGVGRTGAYIVIDAMLEQA
  .|| .|||. . |.. .| .||.  |   ..  | | |.|.| ||| |||.|..... . |.|.  .  ..|...|||||||||||..| .||.|.||
kviyGkitvtrkseevnteytvrtl..svvfgdnirevvqlhytswpdmgvpkytiplmnlirtvkqhhtnsvgaivvhcsaGvGrtGtfitldavldqa

KKSRTVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVLEALTCGNTEIQSENYNQAMQKLA
.  . .|. |..  .|. | .|||. ||| ||..|.||.. ||.| |  . | |  . | 
eaenaidvynfitgvrqnrikmvqvaeqyqfiydalletfvcgdtsiaqdlylqrydsll
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 4-261 3.5e-89 294.0 In-house 42-303 (305) alignment 
Range on Protein: 4-261
Range on HMM: 42-303/305.0
RKPANKNKNRYANIVAYDHSRVVLERVNGDEDSDYINASFIHGYDGTpRSFIASQGPLPPAFEGFWRMVWEQNSQSIVMLTNLVELGKTKCHKYWPDKTE
.| |||.|||...|. .|..|. |   . ..||||||||...||..   ..|..||||.   . |||...|   ..|||||.||| || ||..|||... 
kkeankaknrlkeitlldddriiltekeslddsdyinasyvdgykrk.kkyivaqgPlkntvadfWrliveekvstivmltklveggkdkCrqYWpeskt

T---YGGVTVTLHQSEIFADYEIRTFILSK-AKRSGSRMVRQFHFTVWPDKGVPQYATAVLAFRRKVRALNPRDAG-PVIVHCSAGVGRTGAYIVIDAML
    .| ..|.|.... ..|| .| . .|.  . . || | |...| |||.||||.||..| . ..|.    .| | |..|||||||||||..|..| .|
ekkefgefsvelksektasdyieRklkisiededkesrtvlqyqltdWPdhGvpqfatsllslikrvqkdqkkdkgvpllVhCsagvgRtGvfiavdial

EQAKKSRTVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVLEALTCGNTEIQSENYNQAMQKLA
|..||  .||. ..| .||. |. ||||..|| |.| |. | .|||.|.|  .|.. ...|| 
erlkkEevvdvfevlkqlRskrmkmvqtldqYvflhdaldelitcgdtsiigsnlrarvnklk
0039614 (Phosphotyrosine protein) phosphatases II 3-245 5e-89 293.9 In-house 51-293 (297) alignment 
Range on Protein: 3-245
Range on HMM: 51-293/297.0
ARKPANKNKNRYANIVAYDHSRVVLERVNG-DEDSDYINASFIHGYDGTPRSFIASQGPLPPAFEGFWRMVWEQNSQSIVMLTNLVELGKtKCHKYWPDK
|..|.||.|||| .|..||||||.|  ..| |.||||||||.. ||| ..| |||.|||||  .| ||||||||....|||||.|||||. ||..|||..
allpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfIatqgPlpetvedFwrmvweqgvtvivmLtklvelgr.kcaqywpee

TETYGGVTVTLHQSEIFADYEIRTFILSKakRSGSRMVRQFHFTVWPDKGVPQYATAVLAFRRKVRALNPR--DAGPVIVHCSAGVGRTGAYIVIDAMLE
..|||..|||| . |  ..| .||. ...   . ||.|..|..| ||| |||.... .| | ..||  . .  . |||.|||||||||||..|... |||
ggtygdftvtllkvehldgytvrtlevtn..ngesrtvthfqytgwpdhgvppslellleflelvrealaelpkggpvlVHCsaGvgRtGtfiaaylmle

QAKKSRTVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVLEALTCGN
| .| ..||. . .  ||. ||..||| .|| |.. |.|| | ...
qlekeggvdvleavkelreqRpgavqtpsqyrflydallellkrkl
0047943 (Phosphotyrosine protein) phosphatases II 3-241 1.4e-88 292.2 In-house 33-272 (273) alignment 
Range on Protein: 3-241
Range on HMM: 33-272/273.0
ARKPANKNKNRYANIVAYDHSRVVLervnGDEDSDYINASFIHGYDGTPRsFIASQGPLPPAFEGFWRMVWEQNSQSIVMLTNLVELGKTKCHKYWPDK-
|..|.||.|||| .|..||||||.|    ||..|||||||.. ||. ... ||| |||||  .| |||||||||.. |||||.|||||. ||..|||.. 
allpenkdknrykdilpydhsrvkl....gdggsdyinAsyvdgynlkrk.fiatqgPlpntvedfwrmvweqnvrviVmLtelvelgrekcaqYwpleg

---TETYGGVTVTLHQSEIFADYEIRTFILSKAKRSGSRMVRQFHFTVWPDKGVPQYATAVLAFRRKVRALNPR--DAGPVIVHCSAGVGRTGAYIVIDA
   ..||| .||||   |...|| .||..|.. . . ||.|..||.| ||| |||.. . .| | ..||  .    . |||.|||||||||||..|..| 
gelsltygkftvtllseetkddytvrtleltnlgtgesrtvthfhytgwpdhgvppslesllefielvrkalealpsngpvvVHCsaGvgRtgtfialdl

MLEQAKKSRTVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVLEAL
.|.| .| ..||. ...  ||. ||.|||| ||| |.. |.|| |
lldqlekeggvdvleavkllrsqRpgmvqtpeqyrflyealleyl
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 2-242 2.6e-88 290.8 In-house 35-277 (281) alignment 
Range on Protein: 2-242
Range on HMM: 35-277/281.0
AARKPANKNKNRYANIVAYDHSRVVLERVNGDEDSDYINASFIHGYDGtPRSFIASQGPLPPAFEGFWRMVWEQNSQSIVMLTNLVELGKTKCHKYWPDK
|.....|..|||| ||||||..||.... . ....|||||.|. ||.| .. .||.|||.| ... ||.|||||. . |||.|. .| || |||.||||.
askadenvlknrYsnivaYDatrvkvtpneenkntDYinanfvpgykg.ekeyiatqgPvPaslvafWqmvweqkvsaivmvtreieagklkChrYWPdd

T--ETYGGVTVTLHQSEIFADYEIRTFILsKAKRSGSRMVRQFHFTVWPDKGVPQYATAVLAFRRKV-RALNPRDAGPVIVHCSAGVGRTGAYIVIDAML
.   .|| |||. ...|  | |  |.| | ... . .| |.|...| |||.|||. ....| ||..| .. ...   |...||||||||||.|| .| ..
nselkygdvtvkstaeeekatyierkfkl.eresgetreveqlaytaWPdhGvPattkellefrkevlkltekktkaplvihCsaGvGrtGtyialDrlv

EQAK-KSRTVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVLEALT
.... . ...|... .  |||.|  ||||  ||.|.. |||.|| 
kaveaeleeldvkavvaelrkernlmvqtvvqyefvykavldald
0043336 (Phosphotyrosine protein) phosphatases II 3-239 6.7e-88 290.0 In-house 40-275 (278) alignment 
Range on Protein: 3-239
Range on HMM: 40-275/278.0
ARKPANKNKNRYANIVAYDHSRVVLERVNGDEDSDYINASFIHGYDGTPRsFIASQGPLPPAFEGFWRMVWEQNSQSIVMLTNLVELGKTKCHKYWPDKT
|..|.||.|||| .|..||||||.|. ..||.||||||||.. ||. ... |||.|||||  .| |||||||.....|||||.|||||..||..|||...
allpenkdknrykdilpydhsrvklsllggdldsdYinAsyvdgynvprk.fiatqgPlpetvedFwrmvwelgvttivmLtelvelgrvkcaqYwpggs

ETYGGVTVTLHQSEIFADYEIRTFILSKAKRSGSRMVRQFHFTVWPDKGVPQYATAVLAFRRKVRALNPRDAGPVIVHCSAGVGRTGAYIVIDAMLEQAK
.|||..||||   | ..|| .||. ... . . ||.|...|.. ||| |||   . .| | ..||  .. . |||.|||||||||||..|... .|||..
ltygdftvtllkeehlddytvrtlevtnlgdgesrtvthyhylgwpdhgvpeslsllldflkavrealedsngpvlVHCsaGvgRTGtfialyllleqle

KSRTVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVLE
| ..||. . .  ||. ||..||| .|| |.. |.||
keggvdleeavkelreqRpgavqtpsqyrflyealle
0050432 (Phosphotyrosine protein) phosphatases II 235-538 1.3e-87 289.3 In-house 6-306 (308) alignment 
Range on Protein: 235-538
Range on HMM: 6-306/308.0
SAVLEALTCGNTEIQSENYNQAMQKLAS-VNRKFQMTGYALEFQRLNSVTSreipAEEKSVGEKPQNLHKNRFSDIIALNSCRVMLhkehaDEESDYINA
.|.||.|....|.|. ..... ...|.  ..........  ||..|.||.      .| ||...|.| .|||..||... ..|| |     ||.||||||
dallelllfrdtsilvsslklsvldllkllekaldlglleeefeellsvkp....lleysvallpenkdkNrykdilpydhsRVkl.....degsdYInA

VFLHVR--MERNAFIATQHPLQHTIEDFWRMVTDYDIGTIVMLNNLHEHD-QEYPQYLPVE---GATKYGHIRVSLLSKQEKGDVISTKLKVTR--NKKT
 . ..     ...|||||.||..|.||||||| .... .||||..|.| . . ..|| | |   | ..||...| ||| ....|.. ..|..|   ....
syvdgyssklprkfIatqgPlpntvedFwrmvweqnvrvIvmLtklvengrekcaqYwplelgggsleygkftvtllseevlddytvrtleltnlgdges

HEVRHLHHVSWPDKCIPEVARSVLDLLDEVQASQqqcGNAPVLVQCSNGVGRSGTFCAISSVIERLKTEQVIDVFQVIKRIRANRPGAVESLTQYVFCYQ
..|.|.|. .||| ..|. ....||.|..|. |.   .. |..| ||.||||.|||.|.  ..|.|..|. .|||...|..|  |||.|... ||.|.|.
rtvthfhytnWpdhgvPpspeilldflelvrksl...pggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtpeqylflyr

IIQKYLDSFSDYA
....|| ..  ..
alleylklkltkl
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 2-240 2.6e-86 284.2 In-house 41-278 (288) alignment 
Range on Protein: 2-240
Range on HMM: 41-278/288.0
AARKPANKNKNRYANIVAYDHSRVVLERVNGDEDSDYINASFIHGYDGTpRSFIASQGPLPPAFEGFWRMVWEQNSQSIVMLTNLVELGKTKCHKYWPDK
|.|.. |..|||| ||..||. || |. ..  ...||||||.|.|.... . .||.||||. . . ||..|.|.... |||||.||| |||||..||||.
agrlavnakknRyrnilpyDekrvklkkleeeagaDYinasyidgekkk.kkyiatqgPladtvndfWelvyenktstivmltelveggktkCeeYWPda

TE--TYGGVTVTLHQSEIFADYEIRTFILSkaKRSGSRMVRQFHFTVWPDKGVPQYATAVLAFRRKVRALNPRDAGPVIVHCSAGVGRTGAYIVIDAMLE
 .   || ||||| .|.   |.  |...|   |. . . . |.....|||.|||. .. .|...|.|   |. |.||.|||||||||||| .|..||...
dkpknyGsvtvtlveskeledfvlrkllle..kkkteleitqyqylaWpdhgvPeskapllellrqvkvanqadtgpiivhCsaGvGrtgtFialdalid

QAKKSRTVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVLEA
. ... ..|. . .  ||| |. .|||..|| ||....|. 
aveeedyiDvagtvaklRkqRallvqtlkqYefiyevllsl
0045450 (Phosphotyrosine protein) phosphatases II 2-241 2.1e-85 282.4 In-house 49-304 (307) alignment 
Range on Protein: 2-241
Range on HMM: 49-304/307.0
AARKPANKNKNRYANIVAYDHSRVVLERVNGD-EDSDYINASFI--------HGYDGtPRSFIASQGPLPPAFEGFWRMVWEQNSQSIVMLTNLVELGKT
.|..|.||.|||| .|..|||.||.|  ..|. |||||||||..        .|||  .| ||| |||||  .| ||||.|||... |||||.|||||. 
iallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydl.krkfIatqgPlpetvedFwrmlweqgvtvivmltelvelgre

KCHKYWPDK--TETYGGVTVTLHQSEIFADYEIRTFILSKA-KRSGSRMVRQFHFTVWPDKGVPQYATAVLAFRRKVRALNPR--DAGPVIVHCSAGVGR
||..||||.  . ||| .||||   |. ..| .||. ..   . . ||.|..||.| ||| |||..   .|.| ..||. . .  . |||.|||||||||
kcaqywPdegeeltygnftvtllseehldgytvrtlevtdldgtgesrtvthfhytgwpdhgvppsfeelldfieevrkaleelpkggpvlVHCsaGvgR

TGAYIVIDAMLEQAKKSRT---VDIRNYLIALRKDRPHMVQTKEQYSFIHSAVLEAL
||..|... ||.| .|  |   ||... .  ||. ||..||. ||| |.. |.|| |
tGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyeallell
DSPc_SM00195 3-241 7.9e-85 279.7 In-house 21-262 (263) alignment 
Range on Protein: 3-241
Range on HMM: 21-262/263.0
ARKPANKNKNRYANIVAYDHSRVVLERVNGDEDSDYINASFIHGYdGTPRSFIASQGPLPPAFEGFWRMVWEQNSQSIVMLTNLVELGKTKCHKYWPDK-
|.|..||.|||| ||. |||.|| |.. ...|.||||||..| |.   ....|| |||||  .| |||||||.... |||||. .| ||.||..|||.. 
aekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikga.nkkkkyIatQgPlpstvedFWrmvweekvkiivmlteeeengkekcdrywpees

--TETYGGVTVTLHQSEIFA-DYEIRTFILSKAKRSGSRMVRQFHFTVWPDKGVPQYATAVLAFRRKVRALNPRDAGPVIVHCSAGVGRTGAYIVIDAML
  .||.| ..|.| . |.   ....||. |.| ... .| |.|.... |||.|||. .. ||.. |.|.  . .  ||..|||||||||||....|| .|
ggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkkskstssgpivVhCsaGvgRtgtfvtidiil

EQAKKSRTVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVLEAL
.. ..  .||| . . .||| ||.||||.|||.||. |.||..
skleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi
PTPc_SM00194 3-241 7.9e-85 279.7 In-house 21-262 (263) alignment 
Range on Protein: 3-241
Range on HMM: 21-262/263.0
ARKPANKNKNRYANIVAYDHSRVVLERVNGDEDSDYINASFIHGYdGTPRSFIASQGPLPPAFEGFWRMVWEQNSQSIVMLTNLVELGKTKCHKYWPDK-
|.|..||.|||| ||. |||.|| |.. ...|.||||||..| |.   ....|| |||||  .| |||||||.... |||||. .| ||.||..|||.. 
aekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikga.nkkkkyIatQgPlpstvedFWrmvweekvkiivmlteeeengkekcdrywpees

--TETYGGVTVTLHQSEIFA-DYEIRTFILSKAKRSGSRMVRQFHFTVWPDKGVPQYATAVLAFRRKVRALNPRDAGPVIVHCSAGVGRTGAYIVIDAML
  .||.| ..|.| . |.   ....||. |.| ... .| |.|.... |||.|||. .. ||.. |.|.  . .  ||..|||||||||||....|| .|
ggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkkskstssgpivVhCsaGvgRtgtfvtidiil

EQAKKSRTVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVLEAL
.. ..  .||| . . .||| ||.||||.|||.||. |.||..
skleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi
0051299 (Phosphotyrosine protein) phosphatases II 244-531 2e-84 278.7 In-house 1-286 (288) alignment 
Range on Protein: 244-531
Range on HMM: 1-286/288.0
GNTEIQSENYNQAMQKLAsvnrKFQMTGYALEFQRLNSVTSReipaEEKSVGEKPQNLHKNRFSDIIALNSCRVMLHKEHADEESDYINAVFLHVRMERN
|.|||. |.. ....||     . ..||.. ||..| |..       . |.. .|.||.|||.|||......|| |. .. .|.|||||| ....    .
gdteisveellklvlkll....angltglleefeellsllpd....ltlsaallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyidgynlkr

AFIATQHPLQHTIEDFWRMVTDYDIGTIVMLNNLHEHD-QEYPQYLPVEGATKYGHIRVSLLSKQEKGDVISTKLKVT------RNKKTHEVRHLHHVSW
.|||||.||..|.||||||| .... .||||..|.|.. . ..|| | .| ..||.|.| ||| ....|.. ..|.||       ......|.|.|. .|
kfIatqgPlpntvedFWrmvweqnvrvIvmltklvelgrekcaqYwplggsltygditvtllseevlddytvrtlevtnldlldgdgesrtvthfhytnw

PDKCIPEVARSVLDLLDEVQASQQqCGNAPVLVQCSNGVGRSGTFCAISSVIERLKTEQVIDVFQVIKRIRANRPGAVESLTQYVFCYQIIQKYL
|| ..|. ....||.| .|. ...  |. ||.| ||.||||.|||.|.  ..|.|..|...||....||.|  |||.|... ||.|.|...  ||
pdhgvpdspellldflrlvrkala.sgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtpeqyrfvyealleyl
subfamily_Ptp69D_pd Subfamily Ptp69D 3-260 2.2e-83 274.9 In-house 43-305 (307) alignment 
Range on Protein: 3-260
Range on HMM: 43-305/307.0
ARKPANKNKNRYANIVAYDHSRVVLERVNGDEDSDYINASFIHGYDGTpRSFIASQGPLPPAFEGFWRMVWEQNSQSIVMLTNLVELGKTKCHKYWP-DK
. |  |. |||| .|.|.|. ||.|...||.|||||||||||.||. . ..|||.|.|.    . ||||..||... ||||.|| |  . ||.|||| ..
sekkenalknRyedikafDktRvkLkkingkedsdYinasfikgykek.kkfiaaqdPveatigDfWRmiaeqevtlivmlsnlteknrkkcakYWpied

TETYGGVTVTLHQSEIFADYEIRTFILSKAKRSG-----SRMVRQFHFTVWPDKGVPQYATAVLAFRRKVRALNPRDAGPVIVHCSAGVGRTGAYIVIDA
.  || . |.| ..|   || ||.. .|| | ..     || | |.|.| |.|  ||. |...| . ..|| |.  . .|..|||||||||.| .. .| 
evqygdilvklvseekhsdyiiReldvskkkeesgevedsrkvvqyhytgWkDskvPevargllklieqvrelyklnrsPivvhCsaGvgrsgifvalds

MLEQAKKSRTVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVLEALTCGNTEIQSENYNQAMQKL
.|.| |.  .||| .    ||..|. .||  |||.|.. |.|.  . |.|... .....|...|
llqqlkaedkvdifetvkdLrsqRnllvqsleqYvflyralldyssygdtdedvddledaierl
0040439 (Phosphotyrosine protein) phosphatases II 3-241 5.9e-83 273.5 In-house 6-246 (249) alignment 
Range on Protein: 3-241
Range on HMM: 6-246/249.0
ARKPANKNKNRYANIVAYDHSRVVLERVNGDEDSDYINASFIHGYDGTPRsFIASQGPLPPAFEGFWRMVWEQNSQSIVMLTNLVELGKTKCHKYWP-DK
|..|.||.|||| .|..||||||.|. ..| ..|||||||.|.||. ..| ||| ||||| ..| ||||.||.....|||||.|||||. ||..||| ..
allpenkdknrypdilpydhsrvklsilpglflsdyinAsyidgyyikrr.fiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywplgg

TETYGGVTVTLHQSEIFADYEIRTFILSKAKRSGSRMVRQFHFTVWPDKGVPQYATAVLAFRRKVRALNPR--DAGPVIVHCSAGVGRTGAYIVIDAMLE
. .||..|||| . |...|| .||. |.. . . ||.|.....| ||| |||..   .|.| ..||  . .  . |||.|||||||||||..|... |||
sleygdftvtllsvevkddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaaylmle

QAKKSRTVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVLEAL
| .| ..||. ...  ||. ||..||. ||| |.. |.|| |
qlekelgvdleeavkllrsqRpgavqnpeqyrflyeallell
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 6-261 1.6e-82 272.3 In-house 59-311 (319) alignment 
Range on Protein: 6-261
Range on HMM: 59-311/319.0
PANKNKNRYANIVAYDHSRVVLERVNGDEDSDYINASFIHGYDgTPRSFIASQGPLPPAFEGFWRMVWEQNSQSIVMLTnlvelgKTKCHKYWPDKT-ET
. ||.|||. ||.|.|...| |||..| | ||||||||. ||   .  .||.||||. . . ||||.||.|. .||.||      | || .||| |. ..
dqnkdknriinilafdknvvklerliGeefsdyinasfvtGyq.rkdkyiaaqGPldntladfWrmiweyncstivllt......kdkcsqywplkivik

YGGVTVTLHQSEIFADYEIRTFILSK-AKRSGSRMVRQFHFTVWPDKGVPQYATAVLAFRRKVRALNPRDAG--PVIVHCSAGVGRTGAYIVIDAMLEQA
..   | ..  |  |.| .| . ||. .|  . | ..||||  |||.|||.|.. .. . .||| |. .  .  ...|||||||||||.|||.|..|.. 
eerfkvkvdsveetaeyvvrdielsedgkekdirkitqfhflGwpdvGvpdypsdlmrlvkkvrhltskenhranivvhcsaGvGrtGvyivldvlldrm

KKSRTVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVLEALTCGNTEIQSENYNQAMQKLA
|. . ||. |..  ||..|...||   || ||.||.||    |....   ..   ...|.
keekqvdvynfvrdlrqqrntlvqdlvqykfiysalleehlfghsdvampdfpayleels
Y_phosphatase Protein-tyrosine phosphatase 8-239 3.4e-82 270.8 Pfam-A 1-235 (235) alignment 
Range on Protein: 8-239
Range on HMM: 1-235/235.0
NKNKNRYANIVAYDHSRVVLervNGDED-SDYINASFIHGYDgTPRSFIASQGPLPPAFEGFWRMVWEQNSQSIVMLTNLVELGKTKCHKYWP---DKTE
||.|||| .|..||..|| |   .|.|. ||||||....||. ....|||.||||.  .| ||||||......|||||.|.| |..||..|||   ....
nkkknRykdilpydktrvkl...kgsegpsdYInAnyvkgyk.ekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeesl

TYGGVTVTLH-QSE-IFADYEIRTFILSKAKRS-GSRMVRQFHFTVWPDKGVPQYATAVLAFRRKVRALNPRDAGPVIVHCSAGVGRTGAYIVIDAMLEQ
||| ..|.|  ... . ..| .|.. |.| |..  .|.|.|.|.| |||.|||. ....| . |||.  .  . |||.||||||||||| ....|..|||
tygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleq

AKKSRTVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVLE
... ..||. ...  ||| ||.|||. ||| |.. |.||
leaeeevdvlqivkelRkqRpgmvqsleqYiflykaile
Y_phosphatase Protein-tyrosine phosphatase 8-239 3.4e-82 270.8 In-house 1-235 (235) alignment 
Range on Protein: 8-239
Range on HMM: 1-235/235.0
NKNKNRYANIVAYDHSRVVLervNGDED-SDYINASFIHGYDgTPRSFIASQGPLPPAFEGFWRMVWEQNSQSIVMLTNLVELGKTKCHKYWP---DKTE
||.|||| .|..||..|| |   .|.|. ||||||....||. ....|||.||||.  .| ||||||......|||||.|.| |..||..|||   ....
nkkknRykdilpydktrvkl...kgsegpsdYInAnyvkgyk.ekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeesl

TYGGVTVTLH-QSE-IFADYEIRTFILSKAKRS-GSRMVRQFHFTVWPDKGVPQYATAVLAFRRKVRALNPRDAGPVIVHCSAGVGRTGAYIVIDAMLEQ
||| ..|.|  ... . ..| .|.. |.| |..  .|.|.|.|.| |||.|||. ....| . |||.  .  . |||.||||||||||| ....|..|||
tygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleq

AKKSRTVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVLE
... ..||. ...  ||| ||.|||. ||| |.. |.||
leaeeevdvlqivkelRkqRpgmvqsleqYiflykaile
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 6-261 1.6e-81 268.9 In-house 23-275 (284) alignment 
Range on Protein: 6-261
Range on HMM: 23-275/284.0
PANKNKNRYANIVAYDHSRVVLERVNGDEDSDYINASFIHGYDgTPRSFIASQGPLPPAFEGFWRMVWEQNSQSIVMLTnlvelgKTKCHKYWPDKT-ET
. ||.|||. .|.|.|...| |||. | | ||||||||| ||   .  .||.||||. . . ||||.||.|. .||.||      | || .||| |. ..
dqnkdknrighilafdknvvklerliGeefsdyinasfitGyq.rkdkyiatqGPldntladfWrmiweyncstivllt......kdkcsqywplkivik

YGGVTVTLHQSEIFADYEIRTFILSK-AKRSGSRMVRQFHFTVWPDKGVPQYATAVLAFRRKVRALNPRDAG--PVIVHCSAGVGRTGAYIVIDAMLEQA
..   | ..  |  ..| .| . ||. .|  . | .|||||  |||.|||.|.. .... .||| |. .  .  ...|||||||||||.|||.|..|.. 
eerfkvkvdsveeseeyvvrdielsedgkekdirkirqfhflgwpdvgvpdypsdlmrlvkkvrhltskenhranivvhcsagvgrtgvyivldvlldrm

KKSRTVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVLEALTCGNTEIQSENYNQAMQKLA
|. . ||. |..  ||..|...||   || ||.||.||    |....   ..   ...|.
keekqvdvynfvrdlrqqrntlvqdlvqykfiysalleehlfghsdvalpdfpayleels
0046845 (Phosphotyrosine protein) phosphatases II 274-538 3.3e-81 268.1 In-house 4-281 (284) alignment 
Range on Protein: 274-538
Range on HMM: 4-281/284.0
LEFQRLNSVTSREIpaEEKSVGEKPQNLHKNRFSDIIALNSCRVMLHKEHAD-EESDYINAVFLHVR-----MERNAFIATQHPLQHTIEDFWRMVTDYD
 ||..|.|.|   .   . ||. .|.||.|||..||......|| |. .. | |.|||||| ....      . ...|||||.||..|.||||||| ...
eefeellsltvkll..lslsvallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweqn

IGTIVMLNNLHEHDQ-EYPQYLPVEG-ATKYGHIRVSLLSKQEKGDVISTKLKVTR---NKKTHEVRHLHHVSWPDKCIPEVARSVLDLLDEVQASQQQ-
. .||||..|.| ..  ..|| | ||   .||...| |||...|.|.. ..|..|.   ......|.|.|. |||| ..|. ....|..|..|. .... 
vrvIVmltelvengrekcaqYwplegevltygdftvtllseevkddytvrtleltnlgytgesrtvthfhytswpdhgvppspedlleflrlvrellenl

CGNAPVLVQCSNGVGRSGTFCAISSVIERLKTEQ---VIDVFQVIKRIRANRPGAVESLTQYVFCYQIIQKYLDSFSDYA
 |. |..| ||.||||.|||.|.  ..|.|..|.   ..||....||.|  |||.|..| ||.|.|.... || ..  ..
pgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyealleylklkltll
0042113 (Phosphotyrosine protein) phosphatases II 3-240 3.9e-81 267.3 In-house 4-242 (245) alignment 
Range on Protein: 3-240
Range on HMM: 4-242/245.0
ARKPANKNKNRYANIVAYDHSRVVLERVNGDEDSDYINASFIHGYDGTPRsFIASQGPLPPAFEGFWRMVWEQNSQSIVMLTNLVELGKTKCHKYWP-DK
|..|.||.|||| .|..|||.||.|  ..||.||||||||...||. ||. |||.|||||  .| ||||.||.....|||||...|||. ||..||| . 
allpenkdknrysdilpydhtrvklspdggdldsdyinasyvdgyritpk.fiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywplge

TETYGGVTVTLHQSEIFADYEIRTFILSKAKRSGSRMVRQFHFTVWPDKGVPQYATAVLAFRRKVRALNP-RDAGPVIVHCSAGVGRTGAYIVIDAMLEQ
. |||..||||   |...|| .||. ... . . ||.|...|.. ||| ||| .   .| | . ||      . |||.|||||||||||..|... ||||
sltygdftvtllseehlddytvrtlevtnlgddesrevihyhylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylmleq

AKKSRTVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVLEA
..| ..|.. . .  ||. ||..||| .|| |.. |.|| 
lekelgvsleeavkelrsqRpgavqtpsqyrflyeallel
0039614 (Phosphotyrosine protein) phosphatases II 260-534 2.9e-80 265.2 In-house 22-292 (297) alignment 
Range on Protein: 260-534
Range on HMM: 22-292/297.0
LASVNRKFQMTGYALEFQRLNSVTSreipaEeKSVGEKPQNLHKNRFSDIIALNSCRVMLHKEHA-DEESDYINAVFLHVRME-RNAFIATQHPLQHTIE
|  .......|.. |||..| |..      . .|....|.| .|||..||......|| |. |   |..|||||| .. .     ..|||||.||..|.|
llllekansktllllefeellslkp.....d.ysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfIatqgPlpetve

DFWRMVTDYDIGTIVMLNNLHEHDQEYPQYLPVEGAtKYGHIRVSLLSKQEKGDVISTKLKVTRNKKTHEVRHLHHVSWPDKCIPEVARSVLDLLDEVQA
|||||| .... .||||..| |... ..|| | ||  .||...| ||. ....... ..|.||.|.....|.|.....||| ..|. ....|..|..|. 
dFwrmvweqgvtvivmLtklvelgrkcaqywpeegg.tygdftvtllkvehldgytvrtlevtnngesrtvthfqytgwpdhgvppslellleflelvre

SQQQC-GNAPVLVQCSNGVGRSGTFCAISSVIERLKTEQVIDVFQVIKRIRANRPGAVESLTQYVFCYQIIQKYLDSF
 .... .. |||| ||.||||.|||.|.  ..|.|..|. .||....|..|  |||||... ||.|.|......|  .
alaelpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydallellkrk
subfamily_PTPN6_pd Subfamily PTPN6 3-239 8.6e-80 263.0 In-house 49-295 (306) alignment 
Range on Protein: 3-239
Range on HMM: 49-295/306.0
ARKPANKNKNRYANIVAYDHSRVVLErVNGDEDSDYINASFIH-GYDGTPRSFIASQGPLPPAFEGFWRMVWEQNSQSIVMLTNLVELGKTKCHKYWPDK
..|| ||.|||| ||. .||.||.|.  ..  .||||||..|.    |. .|.||.|| |.   . ||||||..||. |||.|. || || || .||||.
gakpenkeknryknilPfDhtrvilk.epsvpgsdyinanyikkevkgsdksyiatqgclettvsdFWrmvwqensrvivmttkevErgkekCarYWPde

T--ETYGGVTVTLHQSEIFADYEIRTFILSK-AKRSGSRMVRQFHFTVWPDKGVPQYATAVLAFRRKVRA----LNPRDAGPVIVHCSAGVGRTGAYIVI
.  |.|| ..||  ...  |||..|.. .||  | . .| |.|.||..|||.|||.   |||.| ..|..    |. ..|||..||||||.||||..|||
eekeeyGkisvtnvseksladYilRelsvskkkkkkeerevfqyhfksWPdhgvpkdpgavLdfledvnrkqeeleeaeagpivvhCsaGiGRtGtfivi

DAMLEQAKKS---RTVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVLE
|..|.. .|.     .||..    .|. |  .|||..|| |.. |. .
Dillkliekkgldadidiqklvksvreqrsglvqteqqykfvykaikk
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 3-292 1.1e-79 262.9 In-house 38-326 (515) alignment 
Range on Protein: 3-292
Range on HMM: 38-326/515.0
ARKPANKNKNRYANIVAYDHSRVVLERVNGDEDSDYINASFIHGYDGtPRSFIASQGPLPPAFEGFWRMVWEQNSQSIVMLTNLVELGKTKCHKYWPD--
|..  | .|||| ||. || .|| || .| . .|||.|||.|...|   ...||||||.. . . |||.|...|   |.|.|.| |  | || |||||  
aqeeinfkknryknilPydsvrvklevindnPhsdyfnasyipsfdn.dkayiasqgPnkasvddfWrlvlqenvttiamvtklkegdkikcgkyWPdkp

-KTETYGGVTVTLHQSEIFADYEIRTFILSKAKRsgSRMVRQFHFTVWPDKGVPQYATAVLAFRRKVRALNPRDAGPVIVHCSAGVGRTGAYIVIDAMLE
 ..  .| . | |   |  ..  .|.. . | .   || | ||||| |||||||. ....| . ..|.| . . . |.|.|||||||||| .| || .. 
gdsvkfGsikvelvsleactggikrkltvlkgdd..srtvtqfhfteWPdkGvpkhtssllklikevkadhgqythpliihcsaGvGrtGvvisidsvva

QAKKSRTVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVLEALTCGNTEIQSENYNQAMQKLASVNRKFQMTGYALEFQRLNSVTSrEIPAEEK
.||..|.||. |..  .|..||..|||.|||.||. |||| |   || |    . . .| | |       .  . ||| |.|..  . || . 
hakttrmvdvfnfvtnirqkrpylvqtqeqyafiygavledllwrntlipvihftdhlqdlhssgdgrgrskmtkefqtlkslcp.dppasqt
0040438 (Phosphotyrosine protein) phosphatases II 266-531 2.2e-79 262.3 In-house 14-276 (317) alignment 
Range on Protein: 266-531
Range on HMM: 14-276/317.0
KFQMTGYALEFQRLNSVtsreiPAEEKSVGEKPQNLHKNRFSDIIALNSCRVMLHKEHADEESDYINAVFLHVRMERNAFIATQHPLQHTIEDFWRMVTD
| ..|.   ||..| |.     . .. ||.|.|.| .|||..||. . ..|| |. .  |..|||||| . ..  ....|||||.||..|.||||||| .
ksdftalleefedllsl.....kldtysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyvdgpnlkrkfIatqgPlpntvedFwrmvwe

YDIGTIVMLNNLHEHD-QEYPQYLPVEGATKYGHIRVSLLSKQEKGDVISTKLKVT--RNKKTHEVRHLHHVSWPDKCIPEVARSVLDLLDEVQASQQqC
.....||||..| | . . . || | .. ..||...| ||| .|..... ..|.|.  .......|.|.|. .||| ..|.  ...||.|..|.....  
qgvtvivmLteleelgrekcaqYwplgetltygdftvtllseeelagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfleavreale.d

GNAPVLVQCSNGVGRSGTFCAISSVIERLKTEQVIDVFQVIKRIRANRPGAVESLTQYVFCYQIIQKYL
.. |||| ||.||||.|||.|.  ..|.|..|. .||....|..|. |||||... ||.|.|.....||
pggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalleyl
0045098 (Phosphotyrosine protein) phosphatases II 4-244 4.3e-79 261.1 In-house 29-275 (278) alignment 
Range on Protein: 4-244
Range on HMM: 29-275/278.0
RKPANKNKNRYANIVAYDHSRVVlervngdedsDYINASFIHGYdgtPRSFIASQGPLPPAFEGFWRMVWEQNSQSIVMLTNLVELGKTKCHKYWPDKT-
 .. |..|||| .|..||||||.          ||||||.|.||   |. ||| |||||  .. ||||.||.....|||||.|||||. ||..|||..  
lylgnldknRykdilpydhsrVk..........dYINAsyidgy...pkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrekcaqywpeggs

ETYGGVTVTLHQSEIFADYEIRTFILSKA----KRSGSRMVRQFHFTVWPDKGVPQYA--TAVLAFRRKVRALNPR-------------DAGPVIVHCSA
.|||..|||| . |.. || .||...       .   || |...|.. ||| ||| .   . .| . . .|. . .             . |||.|||||
ltygdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsggpvlVHCsa

GVGRTGAYIVIDAMLEQAkkSRTVDIRNYLIALRKDRPH-MVQTKEQYSFIHSAVLEALTCG
||||||...... |||.    ..||. ...  ||. ||. .||..||| |.. ..|| | .|
GvgRtGtlvaaylmlell..eggvdlleavkelrsqRpglavqnleqyrflyefllelllrg
subfamily_PTPN12_pd Subfamily PTPN12 2-241 1.4e-78 258.7 In-house 34-277 (290) alignment 
Range on Protein: 2-241
Range on HMM: 34-277/290.0
AARKPANKNKNRYANIVAYDHSRVVLERVNGDEDSDYINASFIHGYDGTpRSFIASQGPLPPAFEGFWRMVWEQNSQSIVMLTNLVELGKTKCHKYWPDK
|..|. |..|||| .|. ||.|||.|.. ...|.||||||.||.| .|.  ..||.||||| . . ||||.||.| . .||. ..|||||.||..|||..
agekeenvkknrykDilPydksrvelskieeeegsdYinanfikgvegk.leyiaaqgPLpktlddfWrmiweknveivvmaCrevelgkkkCerYWpee

T---ETYGGVTVTLHQSEIFA-DYEIRTFILSKAkrSGSRMVRQFHFTVWPDKGVPQYATAVLAFRRKVRALNPRDAGPVIVHCSAGVGRTGAYIVIDAM
.    ..| ..|||.. . .  |. |||. . .   . ||.|.|||.| |||.|||. |. .|.. ..|| |. ... |..|||||||||||. |.|| .
geeelefgefevtleeekavdddflirtLkveaq..kesrkvyqfhYtaWPDhgvPssaksllelielvrelqesedaPlvvhCsaGvGrtGtiiaidyv

LEQ---AKKSRTVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVLEAL
 |.    | . ..|. . .. |||.|. .|||||||.... ||.| .
rellkaekipeeldvfdlvlelrkqraalvqtkeqyelvykavaelv
0036941 (Phosphotyrosine protein) phosphatases II 262-531 1.9e-78 259.1 In-house 5-277 (297) alignment 
Range on Protein: 262-531
Range on HMM: 5-277/297.0
SVNRKFQMTGYALEFQRLnsvtSREIPAEEKSVGEKPQNLHKNRFSDIIALNSCRVMLhkehADEESDYINAVFLHVRMERNAFIATQHPLQHTIEDFWR
 ..........  ||..|     . ..  ..||...|.||.|||..||......|| |     ||.|||||| .. .    ..|||||.||..|.|||||
llekllflalllkefeel....lpllllgslsvallpenleknRykdilpydhtRVkl....ddegsdYinAsyvdgydlkrkfIatqgPlpntvedFWr

MVTDYDIGTIVMLNNLHEHDQ-EYPQYLPVE--GATKYGHIRVSLLSKQE--KGDVISTKLKVTR--NKKTHEVRHLHHVSWPDKCIPEVARSVLDLLDE
|| .... .||||..| | .   ..|| | |  .  .||...| ||| ..  ..|.. ..|.||   |.....|.|.|. .||| ..|| ..|.||....
mvweqnvtvIvmltelvelgrekcaqywpleegesltygdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfiel

VQASQQQC-GNAPVLVQCSNGVGRSGTFCAISSVIERLK---TEQVIDVFQVIKRIRANRPGAVESLTQYVFCYQIIQKYL
|.  ...  .. |||| ||.||||||||.|.  ....|.   .|. .|.....| .|  |||||..| ||.|.|......|
vrkvlkllpsggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallell
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 2-263 3e-78 257.8 In-house 38-299 (315) alignment 
Range on Protein: 2-263
Range on HMM: 38-299/315.0
AARKPANKNKNRYANIVAYDHSRVVLERVNGDEDSDYINASFIHGYDGtPRSFIASQGPLPPAFEGFWRMVWEQNSQSIVMLTNLVELGKTKCHKYWPD-
.||.. | .|||| ||. .|..||.|| .. . ||||||||.|...|   ...|||||||. . . |||||....  .|||.|.. |  | || .|||| 
varetinfkknryknilPldsarvkleviddsPdsdyinasyiksvdd.dkayiasqgPlkasvddfwrmvlqekvttivmvtkkqegdkikcrqywPdr

--KTETYGGVTVTLHQSEIFADYEIRTFILSKAKRsgSRMVRQFHFTVWPDKGVPQYATAVLAFRRKVRALNPRDAGPVIVHCSAGVGRTGAYIVIDAML
  ..  .| . |.| . |  .|  .| ... |..   || | ||.|| ||||||.. ....| . ..|.| | ..  ...|||||||||||  | || ..
kadsvefGsikvellsleadtdgvarklvtrksee..srtvtqfqftewPdkGvdkqtssllklikevkadngkkefsllvhcsaGvGrtGvvisidevv

EQAKKSRTVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVLEALTCGNTEIQSENYNQAMQKLASV
.|.|..|.||. |..  ||..||..|||.|.|.||. |||| |   || |   .. . .| | . 
aqikrtrsvdvfnfvknlrakrpylvqteeeyafiydavledllwrntlilvihftdhlqdlhts
0047943 (Phosphotyrosine protein) phosphatases II 263-531 5.6e-78 257.5 In-house 5-272 (273) alignment 
Range on Protein: 263-531
Range on HMM: 5-272/273.0
VNRKFQMTGYALEFQRLNSVTSreipAEEKSVGEKPQNLHKNRFSDIIALNSCRVMLhkehADEESDYINAVFLHVRMERNAFIATQHPLQHTIEDFWRM
.......|....||..| |..       ..||...|.|..|||..||......|| |     |..|||||| .. .    ..|||||.||..|.||||||
lekllgltllleefelllslkp....lltysvallpenkdknrykdilpydhsrvkl....gdggsdyinAsyvdgynlkrkfiatqgPlpntvedfwrm

VTDYDIGTIVMLNNLHEHDQ-EYPQYLPVEG---ATKYGHIRVSLLSKQEKGDVISTKLKVTR--NKKTHEVRHLHHVSWPDKCIPEVARSVLDLLDEVQ
| .... .||||..|.| ..  ..|| | ||    ..||...| ||| ..|.|.. ..|..|.  ......|.|.|. .||| ..|.   |.|.....|.
vweqnvrviVmLtelvelgrekcaqYwpleggelsltygkftvtllseetkddytvrtleltnlgtgesrtvthfhytgwpdhgvppslesllefielvr

ASQQQC-GNAPVLVQCSNGVGRSGTFCAISSVIERLKTEQVIDVFQVIKRIRANRPGAVESLTQYVFCYQIIQKYL
  .... .| ||.| ||.||||.|||.|.  ....|..|. .||....|..|  |||.|... ||.|.|... .||
kalealpsngpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrflyealleyl
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 275-538 2.7e-77 254.9 In-house 25-287 (318) alignment 
Range on Protein: 275-538
Range on HMM: 25-287/318.0
EFQRLNSVtsREIPAEEKSvgEKPQNLHKNRFSDIIALNSCRVMLHKEHADEESDYINAVFLHVRMERNAFIATQHPLQHTIEDFWRMVTDYDIGTIVML
|..||. .  .| ... ||   .| | .|||. .|.| ...|| |.. . .|.|||||| ..   ....|.||.| || .||||||||| . .  .||||
eyerlsrs..eetvtslks..lepvnkaknryanilaydhtrvkLqmlegeegsDyinanyidGyrrkkayiaaqaPlpetieDfWrmvWeqnsavivml

NNLHEHDQ-EYPQYLPVEGATKYGHIRVSLLSKQEKGDVISTKLKVTRNKK--THEVRHLHHVSWPDKCIPEVARSVLDLLDEVQASQQQCGNAPVLVQC
 ...|. .    .| | .|...||...| | .. | .| .  ..||||...  . .||  |. ||||. .|| . |.|||. .|.. ||..|. |..| |
tqeeergkakvhryWPskgsrsygklvvelkeevelsdyvlrefkvtrteeeesrqvrqyhytsWpdegvpesgaslldlvrqvskaqqksgagpivvhC

SNGVGRSGTFCAISSVIERLKTEQVIDVFQVIKRIRANRPGAVESLTQYVFCYQIIQKYLDSFSDYA
| |||| |.|.|.....||.| |...||||..|..| .|.  |    ||.|.|......| |.  ..
saGvGrtGvfiavdillerikaealvDvfqtvkqlreqrnlmvqtedqyefiydvllealasgdtev
0037934 (Phosphotyrosine protein) phosphatases II 3-239 5.6e-77 253.8 In-house 5-240 (243) alignment 
Range on Protein: 3-239
Range on HMM: 5-240/243.0
ARKPANKNKNRYANIVAYDHSRVVLervngdEDSDYINASFIHGYDgtpRsFIASQGPLPPAFEG----FWRMVWEQNSQSIVMLTNLVELGKTKCHKYW
|..|.|..|||| .|..||||||.|      |.||||||..| ...   | .||.|||||  .|     ||||.||.....|||||.|||||. ||..||
allpenlsknrysdilpydhsrvkl......egsdyinanliyvtp...r.liatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqyw

PDKTeTYGGVTVTLHQSEIFADYEIRTFILSKAK-RSGSRMVRQFHFTVWPDKGVPQYATAVLAFRRKVRAL--------NPRDAGPVIVHCSAGVGRTG
|... |||..|||| ..| ..|| .||. |.  .    .|.|...|.. ||| |||.  . .|.| ..||.         .  . |||.|||||||||||
pgev.tygdftvtllseehlddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRtG

AYIVIDAMLEQAkksrTVDIRNYLIALRKDRPH-MVQTKEQYSFIHSAVLE
..|... ||..     .||. ...  ||. ||. .||| .|| |.. |.||
tliaaylmllll....gvdleeavkllreqRpgkavqtpsqyrflyealle
subfamily_PTPRD_pd Subfamily PTPRD 342-537 1.4e-76 253.4 In-house 90-287 (564) alignment 
Range on Protein: 342-537
Range on HMM: 90-287/564.0
RNAFIATQHPLQHTIEDFWRMVTDYDIGTIVMLNNLHEHDQ-EYPQYLPVEGATKYGHIRVSLLSKQEKGDVISTKLKV--TRNKKTHEVRHLHHVSWPD
|.|.||||.||..|||||||||..... |||||..|.|... .. .| | .| ..||.. |.| ...|. |.. ...|.  .......|||. |..||||
rkayIAtqgPlaetiedFWRmvweqnsstiVmltkleEkgkvkchkYWPekgtetygeltVtleeeeeladyeirtfklkkkkssesreVrqFhFtsWPd

KCIPEVARSVLDLLDEVQASQqQCGNAPVLVQCSNGVGRSGTFCAISSVIERLKTEQVIDVFQVIKRIRANRPGAVESLTQYVFCYQIIQKYLDSFSDY
...|| |.|.|||...|.|.. .... |..|.||.||||.|||..|....||.|.|...|..|..|..|..|.  |.. .||.|....|...|..... 
hgvpesatslLdlirkvraln.epdagPivVhCSaGVGRTGtfividamlerikeektvDiyqyvkalrkqRnamVqteeQYiFiheailealacgnte
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 269-535 2.7e-76 251.7 In-house 22-287 (319) alignment 
Range on Protein: 269-535
Range on HMM: 22-287/319.0
MTGYALEFQRLNSVTSReipaeEKSVGEKPQNLHKNRFSDIIALNSCRVMLHKEHADEESDYINAVFLHVRMERNAFIATQHPLQHTIEDFWRMVTDYDI
.|. . ||. |.  ..      . .  .|..| .|||...|.| . .||.| . .  |.|||||| |.    ||..||||| ||..||||||||| ....
etllekefkllkeavnd.....tfdsaskeenkkknryqnilaydrtrvvlseldgvegsdyinasfidgyqerekfiatqaPlentiedfWrmvWeees

GTIVMLNNLHEHDQ-EYPQYLPVEGATKYGHIRVSLLSKQEKGDVISTKLKVTRNKK---THEVRHLHHVSWPDKCIPEVARSVLDLLDEVQASQQQCGN
 ..|||..| |. . .. .| | |  ..||.. | |....|. |.|  |||. ...    | || | .. .|||. .|| |.|.|||| ... |...  .
sivvmltklveklkvklkkywpeenfeeyGrlivtleeeeeledyiirklklnkkssevetRevkhfqyteWpdhdvPekatslldllkrirksrektqs

APVLVQCSNGVGRSGTFCAISSVIERLKTEQVIDVFQVIKRIRANRPGAVESLTQYVFCYQIIQKYLDSFS
 |. | ||.|||| |||.... ..||.| |.|.|||....|.|. |.  |.   || |.|... .......
gPivvhCsaGvGRtGtfivldamlervkeegvlDvfstvsrlRtqRnimvqrpeqYkfiyealleaveagd
0045450 (Phosphotyrosine protein) phosphatases II 268-531 3.4e-76 252.2 In-house 25-304 (307) alignment 
Range on Protein: 268-531
Range on HMM: 25-304/307.0
QMTGYALEFQRLNSVTSREipAEEKSVGEKPQNLHKNRFSDIIALNSCRVMLHKEHAD-EESDYINAVFL--------HVRMERNAFIATQHPLQHTIED
 .||.. ||..|.||| .     | |....|.| .|||..||......|| |. .. . |.|||||| .         ..    ..|||||.||..|.||
fltgllkefekllsvtvfl..lgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydlkrkfIatqgPlpetved

FWRMVTDYDIGTIVMLNNLHEHDQE-YPQYLPVEGAT-KYGHIRVSLLSKQEKGDVISTKLKVT---RNKKTHEVRHLHHVSWPDKCIPEVARSVLDLLD
||||. ......||||..| |...| ..|| | || .  ||...| |||........ ..|.||    ......|.|.|. .||| ..|.   ..||...
FwrmlweqgvtvivmltelvelgrekcaqywPdegeeltygnftvtllseehldgytvrtlevtdldgtgesrtvthfhytgwpdhgvppsfeelldfie

EVQASQQQC-GNAPVLVQCSNGVGRSGTFCAISSVIERLKTEQV---IDVFQVIKRIRANRPGAVESLTQYVFCYQIIQKYL
||.. .... .. |||| || ||||.|||.|.  ....|..|..   .|.....|..|. |||||... ||.|.|......|
evrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyeallell
DSPc_SM00195 275-531 4.8e-76 250.9 In-house 5-262 (263) alignment 
Range on Protein: 275-531
Range on HMM: 5-262/263.0
EFQRLNSVTSREipaeEKSVGEKPQNLHKNRFSDIIALNSCRVMLHKEHADEESDYINAVFLHVRMERNAFIATQHPLQHTIEDFWRMVTDYDIGTIVML
||..|.. || .    |.. .||..| .|||...|.  .. || |.||. .|.|||||| .. .  .....||||.||..|.|||||||.. .. .||||
efekleestspk....etteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivml

NNLHE-HDQEYPQYLPVE--GATKYGHIRVSLLSKQEKG-DVISTKLKVTRNK--KTHEVRHLHHVSWPDKCIPEVARSVLDLLDEVQASQQQCgNAPVL
..  | . ..  .| | |  | ...|.|.| | ....|  ..| ..|..| ..  .|..|..... .|||. .|. ..|||.|| .|. |...  ..|..
teeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkksksts.sgpiv

VQCSNGVGRSGTFCAISSVIERLKTEQVIDVFQVIKRIRANRPGAVESLTQYVFCYQIIQKYL
|.||.||||.|||..|......|..|. .|.|...|..| .|||.|..|.|| |.|..| .|.
VhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi
PTPc_SM00194 275-531 4.8e-76 250.9 In-house 5-262 (263) alignment 
Range on Protein: 275-531
Range on HMM: 5-262/263.0
EFQRLNSVTSREipaeEKSVGEKPQNLHKNRFSDIIALNSCRVMLHKEHADEESDYINAVFLHVRMERNAFIATQHPLQHTIEDFWRMVTDYDIGTIVML
||..|.. || .    |.. .||..| .|||...|.  .. || |.||. .|.|||||| .. .  .....||||.||..|.|||||||.. .. .||||
efekleestspk....etteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivml

NNLHE-HDQEYPQYLPVE--GATKYGHIRVSLLSKQEKG-DVISTKLKVTRNK--KTHEVRHLHHVSWPDKCIPEVARSVLDLLDEVQASQQQCgNAPVL
..  | . ..  .| | |  | ...|.|.| | ....|  ..| ..|..| ..  .|..|..... .|||. .|. ..|||.|| .|. |...  ..|..
teeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkksksts.sgpiv

VQCSNGVGRSGTFCAISSVIERLKTEQVIDVFQVIKRIRANRPGAVESLTQYVFCYQIIQKYL
|.||.||||.|||..|......|..|. .|.|...|..| .|||.|..|.|| |.|..| .|.
VhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi
0043336 (Phosphotyrosine protein) phosphatases II 265-531 2.5e-75 248.8 In-house 15-277 (278) alignment 
Range on Protein: 265-531
Range on HMM: 15-277/278.0
RKFQMTGYALEFQRLNSVTSreipaEEKSVGEKPQNLHKNRFSDIIALNSCRVMLHKEHADEESDYINAVFLHVRMERNAFIATQHPLQHTIEDFWRMVT
 .   |.. |||..|.|..      ...|....|.| .|||..||......|| |. .  |. |||||| .. .    ..|||||.||..|.||||||| 
llnlktllllefeellsfkl.....dtysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyvdgynvprkfiatqgPlpetvedFwrmvw

DYDIGTIVMLNNLHEHD-QEYPQYLPvEGATKYGHIRVSLLSKQEKGDVISTKLKVT--RNKKTHEVRHLHHVSWPDKCIPEVARSVLDLLDEVQASQQq
.... |||||..| |.. . . || | .| ..||...| ||. ....|.. ..|.||  .......|.|.|...||| ..||   ..||.| .|.  .. 
elgvttivmLtelvelgrvkcaqYwp.ggsltygdftvtllkeehlddytvrtlevtnlgdgesrtvthyhylgwpdhgvpeslsllldflkavreale.

CGNAPVLVQCSNGVGRSGTFCAISSVIERLKTEQVIDVFQVIKRIRANRPGAVESLTQYVFCYQIIQKYL
  | |||| ||.||||.|||.|.  ..|.|..|. .|.....|..|  |||||... ||.|.|.... ||
dsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflyealleyl
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 2-266 3.8e-75 248.0 In-house 42-313 (325) alignment 
Range on Protein: 2-266
Range on HMM: 42-313/325.0
AARKPANKNKNRYANIVAYDHSRVVLERVNGDEDSDYINASFIHGYDGTpRSFIASQGPLPPAFEGFWRMV--WEqnsQSIVMLTNLVELGKTKCHKYWP
.| ||.||.|||. |.||.|.||||||  . | .|||||||... . .    |.|.| ||. . . .||.|  |.    |.|...| ..||| .| .|||
vamkpenkaknrfknvvaldksrvvletkkddpssdyinasylrddkkk.dvflaaqaPltatindlWrlvldWr...csvvvvlneldlgkdrcavywp

DK---TETYGGVTVTLHQSEIFADYEIRTFILSKAKRSGSRMVRQFHFTVWPDKGVPQYATAVLAFRRKVRAL------NPRDAGPVIVHCSAGVGRTGA
..   . |.||. | |   | ..||  | . . ..|.  .| |.||..  |.| ||... ...... . | |.      | . ..|..|||||||||||.
kemgksktfGglevklrtieeisdyvhrvldvkqvkkGetrsvkqfqlqswddmGvqkrpatlisilqlvkavservtantkastpilvhcsaGvGrtGv

YIVIDAMLEQAKKSRTVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVLEALTCGNTEIQSENYNQAMQKLASVNRK
.| . ..|..  .   ||| ...  |||||| ||.| .||..|. |. ||. .|||..   ...  .  |   |  
fislysalakvieesrvdifgfvkklrkdrpsmvetvdqyiliyealveaymsgntdvpvssfeaklsslqernpl
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 3-253 4.6e-75 247.5 In-house 46-296 (297) alignment 
Range on Protein: 3-253
Range on HMM: 46-296/297.0
ARKPANKNKNRYANIVAYDHSRVVLERVNGDEDSDYINASFIHGYDGtprSFIASQGPLPPAFEGFWRMVWEQNSQSIVMLTNLVELGKtKCHKYWPDKT
|.|  | .|.||.||. || ||| |. || | ||||.||||..|.      .|..| | . . . ||.||.... . ||||... |  | || .||.||.
aekkvnfeksRYkniLPydssRvkLaivnddpdsDyvnasfvkgnkh...rlittqmPmkatvadfWamvldeqvstivmlnddnerdk.kcaryWsdkg

-ETYGGVTVTLHQSEIFADYEIRTFILSKAKRSGSRMVRQFHFTVWPDKGVPQ--YATAVLAFRRKVRALNPRDAG-PVIVHCSAGVGRTGAYIVIDAML
  |.| |.|.|.  .    .  |.. ..| |    |.|.|..|. |||| |..   |...| .   ||      |  |..|||.||||||| .. || ..
vttfGdvsvvllsvsereGfikrelevtkgkakarrvvkqyqfveWPdkaverkdsassllklisevrkdfsqnaegPllvhclaGvGrtgvlltidsvv

EQAKKSRTVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVLEALTCGNTEIQSENY
 .||.  .||| ...  ||..||..|||||||.|.. |||||| . .|.||.. .
aeakrekevdifglvkklrqerpylvqtkeqykfvyvavleallsedtriqasyf
subfamily_PTPN9_pd Subfamily PTPN9 2-239 2.3e-74 245.1 In-house 36-288 (297) alignment 
Range on Protein: 2-239
Range on HMM: 36-288/297.0
AARKPANKNKNRYANIVAYDHSRVVLERVNGDEDSDYINASFIHGYDgTPRSFIASQGPLPPAFEGFWRMVWEQNSQSIVMLTNLVELGKTKCHKYWP--
|....|| .||||.... ||..||||..|..|| ||||||.|. ||   ...||| ||||. ... ||||||||.   ||| | .|| |. || .|||  
asklranleknrytdvlcydetrvvlakvdedeasdyinanfvdGyk.qkkafiatqGplkktvsdfWrmvWeqevlvivmttrvvergrlkcgqyWple

-DKTETYGGVTVTLHQSEIFADYEIRTFILSKAKRSGSRMVRQFHFTVWPDKGVPQYATAVLAFRRKVRA--------LNPRDA-----GPVIVHCSAGV
 .... .| ..|.  . |   ||..|.. ....| . || |  | |. ||| |||. |...| ...|||         | ....      |..||||||.
eessaefgdlsvsnveveeeedykvrvleiknvkteesrkvthfqflsWPdyGvPssaaslldvlekvrekqalavkelgdewkghpsgPPivvhcsaGi

GRTGAYIVIDAMLEQAKKSRTVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVLE
||||..| .|  |.. ..  |||... .  ||. | ...|| ||| | . ||||
GrtGtfitldiclsrleevgtvdvvetvkllrtqrafsiqtpeqyefcylavle
subfamily_PTPRA_pd Subfamily PTPRA 280-530 6.8e-74 243.7 In-house 39-294 (330) alignment 
Range on Protein: 280-530
Range on HMM: 39-294/330.0
NSVTSREIPAEeKSVGEKPQNLHKNRFSDIIALNSCRVMLHKEHADEESDYINAVFLHVRMERNAFIATQHPLQHTIEDFWRMVTDYDIGTIVMLNNLHE
|.. . .| |    . .| .| .|||. .|.  .  ||.| . .  |||||||| |..   |.. |||.| |...|.||||||. ...  ||||| .|.|
nalPagpiqat.lelaskeenkeknrvvnilPydfsrvilsvkeGveesdyinasfidGykekdkfiaaqGPkeetvedfwrmiweqksativmltelke

HDQE-YPQYLPVEGATKYGHIRVSLLSKQEKGDVISTKLKVT------RNKKTHEVRHLHHVSWPDKCIPEVARSVLDLLDEVQASQQQCGNaPVLVQCS
 ..|   || | ||.  ||.|||..  ...  |.   |. |.      |.||.  || .|  ||||  .|  .. .|.|| .|.. .|| .. |. | ||
rkeekcaqywPdeGlvtyGnirvevedetvlvdytvrkflvqqlpdatrekksrlvrqfhftswPdvGvPfepiGmlkllkkvkklnqqsag.pivvhcs

NGVGRSGTFCAISSVIERLKTEQVIDVFQVIKRIRANRPGAVESLTQYVFCYQIIQKY
 ||||.|||.....|.||.|.|...|||...||.|..||  | .. ||.|.|.....|
aGvGrtGtfivldavlervkaerkvdvfefvkrlrlqrpqmvqtdeqyefiykvlley
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 289-534 4.5e-73 241.1 In-house 35-286 (305) alignment 
Range on Protein: 289-534
Range on HMM: 35-286/305.0
AEEKSVGEKPQNLHKNRFSDIIALNSCRVMLHKEHADEESDYINAVFLHVRMERNAFIATQHPLQHTIEDFWRMVTDYDIGTIVMLNNLHEHDQEY-PQY
 |   ||.| .| .|||...|. |.  |..| ... ...|||||| ...   .....|..| ||..|..||||.. .. . ||||| .| | ...   ||
eesidvgkkeankaknrlkeitlldddriiltekeslddsdyinasyvdgykrkkkyivaqgPlkntvadfWrliveekvstivmltklveggkdkCrqY

LPVEGAT--KYGHIRVSLLSKQEKGDVISTKLKVTR---NKKTHEVRHLHHVSWPDKCIPEVARSVLDLLDEVQASQQQCGNAPVLVQCSNGVGRSGTFC
 | . .   ..|.. | | |...  | |  |||..    .|... | ...  .|||. .|. | |.|.|...|| .|..  . |.|| ||.||||.|.|.
WpesktekkefgefsvelksektasdyieRklkisiededkesrtvlqyqltdWPdhGvpqfatsllslikrvqkdqkkdkgvpllVhCsagvgRtGvfi

AISSVIERLKTEQVIDVFQVIKRIRANRPGAVESLTQYVFCYQIIQKYLDSF
|..  .||||.|.|.|||.|.|..| .|...|..| ||||......... ..
avdialerlkkEevvdvfevlkqlRskrmkmvqtldqYvflhdaldelitcg
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 6-239 4.9e-73 240.6 In-house 26-266 (274) alignment 
Range on Protein: 6-239
Range on HMM: 26-266/274.0
PANKNKNRYANIVAYDHSRVVLERVNGDE-DSDYINASFIHGYDGTPRSFIASQGPLPPAFEGFWRMVWEQNSQSIVMLTNLVELGKTKCHKYWPDKTET
. ...|||| .|.  ..|||.||. .... ||.|||| .|.|||.. . ..| ||||| . . ||||......| |||||.| |  ..||..|.||....
fgsqtknryktilPnensrvllesessededssyinanyikGydeeskayvatqGPlpntvadfWrmiyqeevqvivmltklkeaneqkCavyfPdaedy

-----YGGVTVTLHQSEIFADYEIRTFILSKAKRsgSRMVRQFHFTVWPDKGVPQYATAVLAFRRKVRALNPR---DAGPVIVHCSAGVGRTGAYIVIDA
     ||.| .. ..     ||..|...|....|  .| |  . .| |||. .|. |...| . ..|.  . .    ..||.||||||.||||..| |. 
eiserygdveikvekiverndysvrklvlkyler..ersvkhywytdWPdhksPddantlldlvleveesreeenaklapvvvhCsaGiGrtGcfiaisi

MLEQAKKSRTVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVLE
 . | ... .||. .    || ||  ||||.||| .|| |. .
avrqlreeivvdvlkivcnlrldrGGmvqtseqyelihralcl
Y_phosphatase Protein-tyrosine phosphatase 300-528 5.4e-73 240.6 Pfam-A 1-234 (235) alignment 
Range on Protein: 300-528
Range on HMM: 1-234/235.0
NLHKNRFSDIIALNSCRVMLhkEHADEESDYINAVFLHVRMERNAFIATQHPLQHTIEDFWRMVTDYDIGTIVMLNNLHEH-DQEYPQYLP--VEGATKY
|..|||..||.. .. || |  .. ...|||||| ...   | ..|||||.||..|||||||||..... .||||..| |  .....|| |   |. ..|
nkkknRykdilpydktrvkl..kgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeeslty

GHIRVSLL--SKQEKGDVISTKLKVTRNKKT---HEVRHLHHVSWPDKCIPEVARSVLDLLDEVQASQqQCGNAPVLVQCSNGVGRSGTFCAISSVIERL
|.|.| |   .|... ... .||... .|.    .||..||. .|||...|| ..|.|||...|. |. .  ..||.|.||.||||.|||.|.. ..|.|
gdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkveksk.eaksgpvvVhCsaGvgRtgtfvaldilleql

KTEQVIDVFQVIKRIRANRPGAVESLTQYVFCYQIIQ
..|. .||.|..|..|..|||.|.||.||.|.|..|.
eaeeevdvlqivkelRkqRpgmvqsleqYiflykail
Y_phosphatase Protein-tyrosine phosphatase 300-528 5.4e-73 240.6 In-house 1-234 (235) alignment 
Range on Protein: 300-528
Range on HMM: 1-234/235.0
NLHKNRFSDIIALNSCRVMLhkEHADEESDYINAVFLHVRMERNAFIATQHPLQHTIEDFWRMVTDYDIGTIVMLNNLHEH-DQEYPQYLP--VEGATKY
|..|||..||.. .. || |  .. ...|||||| ...   | ..|||||.||..|||||||||..... .||||..| |  .....|| |   |. ..|
nkkknRykdilpydktrvkl..kgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeeslty

GHIRVSLL--SKQEKGDVISTKLKVTRNKKT---HEVRHLHHVSWPDKCIPEVARSVLDLLDEVQASQqQCGNAPVLVQCSNGVGRSGTFCAISSVIERL
|.|.| |   .|... ... .||... .|.    .||..||. .|||...|| ..|.|||...|. |. .  ..||.|.||.||||.|||.|.. ..|.|
gdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkveksk.eaksgpvvVhCsaGvgRtgtfvaldilleql

KTEQVIDVFQVIKRIRANRPGAVESLTQYVFCYQIIQ
..|. .||.|..|..|..|||.|.||.||.|.|..|.
eaeeevdvlqivkelRkqRpgmvqsleqYiflykail
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 267-530 2.2e-72 238.6 In-house 18-278 (288) alignment 
Range on Protein: 267-530
Range on HMM: 18-278/288.0
FQMTGYALEFQRLNSVTSReipaEEKSVGEKPQNLHKNRFSDIIALNSCRVMLHKEHADEESDYINAVFLHVRMERNAFIATQHPLQHTIEDFWRMVTDY
 . ||.  |.. | .. .     .....|....| .|||. .|....  || |.| .  ...||||| ....  .....|||| ||..|..|||..| ..
rnrtgfseeynsLaalekt....ksvtagrlavnakknRyrnilpyDekrvklkkleeeagaDYinasyidgekkkkkyiatqgPladtvndfWelvyen

DIGTIVMLNNLHEHD-QEYPQYLPVEGA-TKYGHIRVSLLSKQEKGDVISTKLKVTRNKKTHEVRHLHHVSWPDKCIPEVARSVLDLLDEVQASQQQCgN
.. |||||..| | . ..  .| | ..  ..||.. | |....|..|..  || . ..|.  |. .... .|||. .|| .. .|.||. |. ..|.   
ktstivmltelveggktkCeeYWPdadkpknyGsvtvtlveskeledfvlrklllekkkteleitqyqylaWpdhgvPeskapllellrqvkvanqad.t

APVLVQCSNGVGRSGTFCAISSVIERLKTEQVIDVFQVIKRIRANRPGAVESLTQYVFCYQIIQKY
 |..|.||.||||.||| |.  .|.....|..|||. .....| .|.  |. |.||.|.|... . 
gpiivhCsaGvGrtgtFialdalidaveeedyiDvagtvaklRkqRallvqtlkqYefiyevllsl
0040439 (Phosphotyrosine protein) phosphatases II 292-531 3.9e-71 234.9 In-house 3-246 (249) alignment 
Range on Protein: 292-531
Range on HMM: 3-246/249.0
KSVGEKPQNLHKNRFSDIIALNSCRVMLHKEHADEESDYINAVFLHVRMERNAFIATQHPLQHTIEDFWRMVTDYDIGTIVMLNNLHEH-DQEYPQYLPV
.||...| |..|||..||......|| |.     . |||||| ....    ..|||||.||..|.||||||. ...|..||||..| |.  . . || | 
ysvallpenkdknrypdilpydhsrvklsilpglflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywpl

EGATKYGHIRVSLLSKQEKGDVISTKLKVT--RNKKTHEVRHLHHVSWPDKCIPEVARSVLDLLDEVQASQQQC-GNAPVLVQCSNGVGRSGTFCAISSV
.| ..||...| ||| ..|.|.. ..|..|   ......|.|.....|||  .|.   ..||....|.  ....  . |||| ||.||||.|||.|.  .
ggsleygdftvtllsvevkddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaaylm

IERLKTEQVIDVFQVIKRIRANRPGAVESLTQYVFCYQIIQKYL
.|.|..|. .|.....| .|  |||||... ||.|.|......|
leqlekelgvdleeavkllrsqRpgavqnpeqyrflyeallell
subfamily_Ptp69D_pd Subfamily Ptp69D 270-532 8.5e-71 233.6 In-house 22-287 (307) alignment 
Range on Protein: 270-532
Range on HMM: 22-287/307.0
TGYALEFQRLNSVtsrEIPaEEKSVGEKPQNLHKNRFSDIIALNSCRVMLHKEHADEESDYINAVFLHVRMERNAFIATQHPLQHTIEDFWRMVTDYDIG
 |.| |...|..    ||.  . .|.||  |. |||. ||.| .. ||.|.|   .|.|||||| |..   |.. ||| | |.. ||.|||||... .. 
fglakeyekLear...eid.kstkvsekkenalknRyedikafDktRvkLkkingkedsdYinasfikgykekkkfiaaqdPveatigDfWRmiaeqevt

TIVMLNNLHEHDQ-EYPQYLPVEGATKYGHIRVSLLSKQEKGDVISTKLKVTRNK-------KTHEVRHLHHVSWPDKCIPEVARSVLDLLDEVQASQQQ
.|||| || |... . ..| |.|  ..||.| | | |.....| |  .|.|...|       ....|   |. .|.|  .|||||..|.|...|.  ...
livmlsnlteknrkkcakYWpiedevqygdilvklvseekhsdyiiReldvskkkeesgevedsrkvvqyhytgWkDskvPevargllklieqvrelykl

CgNAPVLVQCSNGVGRSGTFCAISSVIERLKTEQVIDVFQVIKRIRANRPGAVESLTQYVFCYQIIQKYLD
  ..|..| ||.||||||.| |..|....||.|. .|.|...| .| .|.  |.|| ||||.|. . .| .
n.rsPivvhCsaGvgrsgifvaldsllqqlkaedkvdifetvkdLrsqRnllvqsleqYvflyralldyss
subfamily_PTPN3_pd Subfamily PTPN3 2-240 3.3e-70 231.2 In-house 35-274 (280) alignment 
Range on Protein: 2-240
Range on HMM: 35-274/280.0
AARKPANKNKNRYANIVAYDHSRVVLErvngDEDSDYINASFIHG-YDG--TPRSFIASQGPLPPAFEGFWRMVWEQNSQSIVMLTNLVELGKTKCHKYW
|||||.| .|||| .|..||. || |.    ....|||||...    ..  .   .||.||||. . . ||.|||||.|. |||||.||| |..|||.||
aarkpenlsknryrdilpydatrvklk....esetdyinanyvnmeipstglvnryiatqGPlaktatdfWqmvweqksslivmlttlverGrvkChqyW

PDKTE--TYGGVTVTLHQSEIFADYEIRTFILSKAKRSGSRMVRQFHFTVWPDKGVPQYATAVLAFRRKVRALNPRDAGPVIVHCSAGVGRTGAYIVIDA
|....  .||. .|......    | .| ..|.... . .|.. |. .. |||.|||. .. .| | ..||.|   .  ||.||||||.|||| .|... 
PetedeleygefsvkcekedetksyvlrelvlkdketkeerkilqlqylaWpdhgvPddsadflefvervrklrsgkeePvvvhCsaGigrtGvlillet

MLEQAKKSRTVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVLEA
 |    ... | . . .  .|  |  .|||..|| |.  |.|..
alalieaaepvypldivrtmrdqramlvqtasqykfvCeailkv
0042113 (Phosphotyrosine protein) phosphatases II 293-531 4.7e-70 231.1 In-house 2-243 (245) alignment 
Range on Protein: 293-531
Range on HMM: 2-243/245.0
SVGEKPQNLHKNRFSDIIALNSCRVMLHKEHADEESDYINAVFLHVRMERNAFIATQHPLQHTIEDFWRMVTDYDIGTIVMLNNLHEHDQE-YPQYLPVE
||...| | .|||.|||......|| |  .  |. |||||| . ..    . |||||.||..|.||||||. ...| |||||....|.... ..|| | .
svallpenkdknrysdilpydhtrvklspdggdldsdyinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywplg

GATKYGHIRVSLLSKQEKGDVISTKLKVT--RNKKTHEVRHLHHVSWPDKCIPEVARSVLDLLDEVQASQQQCGNAPVLVQCSNGVGRSGTFCAISSVIE
. ..||...| ||| . ..|.. ..|.||  ......||.|.|...||| ..|.  ...||.|..|.  .....| |||| || ||||.|||.|.  ..|
esltygdftvtllseehlddytvrtlevtnlgddesrevihyhylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylmle

RLKTEQVIDVFQVIKRIRANRPGAVESLTQYVFCYQIIQKYL
.|..|. .......|..|  |||||... ||.|.|......|
qlekelgvsleeavkelrsqRpgavqtpsqyrflyeallell
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 6-248 2.1e-69 228.7 In-house 45-285 (287) alignment 
Range on Protein: 6-248
Range on HMM: 45-285/287.0
PANKNKNRYANIVAYDHSRVVLErvngDEDSDYINASFIHGYDGTpRSFIASQGPLPPAFEGFWRMVWEQNSQSIVMLTNLVELGKTKCHKYWPDKT-ET
. ||.|||...|. .|  ||.|.    .|. |||||.|| ||    . ||....|.  .   ||......| . ||||... |  . .|..|||...  .
sqnkdknRltqilvpdnyrvllk....gehpdyinavfidgykek.kafiiaesPmfntarnfWkliddrnvtaivmlcqekendeevcyqyWpeeksvv

YGGVTVTLHQSEIFADYEIRTFILSKAK-RSGSRMVRQFHFTVWPDKG-VPQYATAVLAFRRKVRALNPRDAGPVIVHCSAGVGRTGAYIVIDAMLEQAK
.|  ...| . |. |.| .|.. . . .  .  ..|.|...| |...| |....| .| . .....   |  ....||||..|||.. .. ..  ....|
lGeyniellneevnagyierklevknknkagdkqqvkqyqitnWdstgkvtepqtillvieemyktqrkrgntsivvhCsdtvGrsamfcaaattinkck

KSRTVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVLEALTCGNTEI
.  ..|. . |   |  .|..||| ||| ||  .||| |....|  
teGviDvfqvlksqriqkpgsvqtveqykfindivleyldsfetys
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 5-245 2e-68 225.4 In-house 43-287 (290) alignment 
Range on Protein: 5-245
Range on HMM: 43-287/290.0
KPANKNKNRYANIVAYDHSRVVLERVNGDED--SDYINASFIHGYDGTpRSFIASQGPLPPAFEGFWRMVWEQNSQSIVMLTNLVELGKTKCHKYWPDK-
 . ||..||.|||| ||  |..| ...|..|   .||||..|.||    ...|| |||..     ||...|....  |||||| .| ||.||..||||. 
tssnkllnRfanivvyddnritLrpisghkDCtneyinAcyikgykek.kqyiatqgpvsntlvdFWkliwqekvtiivmltniieegkvkCqqYWpdsd

TETYGGVTVTLHQSEIFADYEIRTFILSKAKR-SGSRMVRQFHFTVWPDKG-VPQYATAVLAFRRKVRALNPRDAGPVIVHCSAGVGRTGAYIVIDAMLE
|..|| ....|.. |.. .| .|.. . . .    ...| |...| |...| |....| .|.... ..    |  ....||||..|||.. .....  ..
tkaygefsikllneetlneyierklevknknsagakqsvtqyqitnwdstgkvtnpqtillvieemyktqrkrgntsivvHCSdtvgrsavfcaaattin

QAKKSRTVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVLEALTCGN
..|.   .|. . |  .|  .| .|||..|| .|.. ||..|.. .
kcktegvidvfqvlksqRiqkpgsvqtvqqyqgifqivltyldsfe
subfamily_PTPN1_pd Subfamily PTPN1 2-248 3.1e-68 224.6 In-house 26-280 (290) alignment 
Range on Protein: 2-248
Range on HMM: 26-280/290.0
AARKPANKNKNRYANIVAYDHSRVVLERvngdEDSDYINASFIHgYDGTPRSFIASQGPLPPAFEGFWRMVWEQNSQSIVMLTNLVELGKTKCHKYWPDK
.|..|.|.|.||| ..  |||||..|||    .| ||||||...  .   ||.| .||||| . . ||.|||||.|...||| ..|| ...||..||| .
eaklpenrnlnryrdvspydhsrikler....adndyinaslve.leeakrsyiltqGPlpntvdhfWqmvWeqkskavvmlnkvvekeqikcaqywPqg

TE----TYG--GVTVTLHQSEIFADYEIRTFILSKAKRSGSRMVRQFHFTVWPDKGVPQYATAVLAFRRKVRAL--NPRDAGPVIVHCSAGVGRTGAYIV
 |    ..    ..|.| . |.   | .|.. | . |   .| . .||.| ||| |||.  .| | |  |||      .| ||...|||||.||.|....
eeekellledtklkvkliseerksyytvrllelenlktqetreilhfhyttwpdfgvpespaaflkflfkvresGslssdvGpavihcsaGiGrsGtfcl

IDAMLEQAKKSR---TVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVLEALTC--GNTEI
.|..| . .|.    .|||.. |..||| |  ..||..|  | . |.||   .  |.. .
vdtclvliekkddlssvdikkvllelrkyrlGliqtadqlrfsylaileGakvikgdssv
subfamily_PTPN13_pd Subfamily PTPN13 3-242 4.2e-68 224.6 In-house 32-270 (273) alignment 
Range on Protein: 3-242
Range on HMM: 32-270/273.0
ARKPANKNKNRYANIVAYDHSRVVLERVNGdedsdYINASFIHGYDGTP-RSFIASQGPLPPAFEGFWRMVWEQNSQSIVMLTNLVELGKTKCHKYWPDK
..| .||.|||| |.. ||..|| |.   |     |||||.|.   |    ..||.||||| . . ||.|||||... |.|.|. .| || |||.|||..
gkkkenkdknryrnvlPydetrvklgdegg.....yinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweqkaeviamvtlekekgkvkchrywPes

TE----TYGGVTVTLHQSEIFADYEIRTFILSKAKRSGSRMVRQFHFTVWPDKGVPQYATAVLAFRRKVRALNPrDAGPVIVHCSAGVGRTGAYIVIDAM
..     .. ..|.| . .   .. .|.. ... . . || | ...|. ||| |||. |. .| | ..|| |.  ||||..||||||.||.|..|.||..
knkklkvsnrlevellkvqkldgfvvralavkdsesgesrevahlnfvkwPdhgvPssaaellqfvaevrrlqt.dagPivvhcsaGiGrsGtlitidvv

LEQAKKSRTVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVLEALT
|.  .. . .|... .  ||. |  .||||.|| |.. |.||.|.
lglierdkefdvkeivrklreqrqgvvqtkdqyifvykailevlk
subfamily_PTPRN_pd Subfamily PTPRN 2-240 7.4e-68 223.4 In-house 50-291 (297) alignment 
Range on Protein: 2-240
Range on HMM: 50-291/297.0
AARKPANKNKNRYANIVAYDHSRVVLERVNGDEDSDYINASFIHGYDGTPRSFIASQGPLPPAFEGFWRMVWEQNSQSIVMLTNLVELGKTKCHKYWPDK
.|... | .|||......|||||| |.. . .|.|||||||.|   |    ..||.||||.     ||.||||| .  ||.||.| | | ..|..||||.
vakaeknvkknrskavlpydhsrvklkeeasaeksdyinasaildhdprapayiatqgplastvadfwqmvweqGvvvivnltrleeegvkqckrywpde

-TETYGGVTVTLHQSEIFA-DYEIRTFILSKAKRSGSRMVRQFHFTVWPDKGVPQYATAVLAFRRKVRALNPRDAGPVIVHCSAGVGRTGAYIVIDAMLE
 .|.|.   | |    |.. || .|.| |   . | .| | ||||  ||..|||  | ..| |||||       . |..||||.|.||||.||.|| .|.
GsevyhiyevhlvsehiwcddylvrsfylknlqtsetrtvtqfhflswpeegvPasaksllefrrkvnksyrGrscpivvhcsdGaGrtGvyilidlvln

QAKK-SRTVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVLEA
. .|  . .||   |  || .||..|.||.|. |. .|| | 
rllkGvkeidiaatlehlrdqrpglvktkdqfefaltavaee
subfamily_PTPRK_pd Subfamily PTPRK 293-527 8.1e-68 223.6 In-house 36-273 (314) alignment 
Range on Protein: 293-527
Range on HMM: 36-273/314.0
SVGEKPQNLHKNRFSDIIALNSCRVMLHKEHADEESDYINAVFLHVRMERNAFIATQHPLQHTIEDFWRMVTDYDIGTIVMLNNLHEHD-QEYPQYLPVE
 .  | .| .|||. ||.| . .||.|.  . | .|||||| ..      .|||.||.|||.|..||||.| |..  .||||..| |.   .  .| | .
daakkdenreknrsgdilaydrsrvflitidgdpssdyinaalidsykrpaafivtqgPlqetvkdfWrlvydencasivmltelvevgrvkClkyWPed

GATkYGHIRVSLLSKQEKGDVISTKLKVTR----NKKTHEVRHLHHVSWPDKCIPEVARSVLDLLDEVQASQQQcGNAPVLVQCSNGVGRSGTFCAISSV
. . ||.|.| |.. . . ....  ..|..     ....|||......|||  .|  |...|.|. .|..||.. .. ...| ||.| ||.|||.||..|
tev.ygdikvelvetellaelvvrifrveklargqeeirevrqfqflgWpdhdvPvsatgllklvrrvkksqee.eaGrivvhCsaGaGrtGtfiaidiv

IERLKTEQVIDVFQVIKRIRANRPGAVESLTQYVFCYQII
.. ...|.|.|||...| .|....  ||   ||.|.|..|
ldmieregvvdvfnavktlrsrkvnmveteeqykfiydvi
0045098 (Phosphotyrosine protein) phosphatases II 289-531 1.4e-66 220.0 In-house 22-272 (278) alignment 
Range on Protein: 289-531
Range on HMM: 22-272/278.0
AEEKSVGEKPQNLHKNRFSDIIALNSCRVMlhkehadeesDYINAVFLHVRmeRNAFIATQHPLQHTIEDFWRMVTDYDIGTIVMLNNLHEH-DQEYPQY
  | ... .. ||.|||..||......||           ||||| ....   ...|||||.||..|..|||||. ...| .||||..|.|   . ..||
pseitpalylgnldknRykdilpydhsrVk..........dYINAsyidgy..pkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrekcaqy

LPVEGATKYGHIRVSLLSKQEKGDVISTKLKVT------RNKKTHEVRHLHHVSWPDKCIPEVA--RSVLDLLDEVQASQQ------------QCGNAPV
 | .|   ||...| ||| .. .|.. ..|.||       . ....|.||| ..||| ..|.    .|.|.||..... ..            . .. ||
wpeggsltygdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsggpv

LVQCSNGVGRSGTFCAISSVIERLktEQVIDVFQVIKRIRANRPG-AVESLTQYVFCYQIIQKYL
|| || ||||.||..|.  ..|.|  |...|.....| .|  ||| ||..| ||.|.|. ....|
lVHCsaGvgRtGtlvaaylmlell..eggvdlleavkelrsqRpglavqnleqyrflyefllell
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 2-264 4e-66 218.0 In-house 39-259 (392) alignment 
Range on Protein: 2-264
Range on HMM: 39-259/392.0
AARKPANKNKNRYANIVAYDHSRVVLERVNGDEDSDYINASFIHGYDGTpRSFIASQGPLPPAFEGFWRMVWEQNSQSIVMLTNLVELGktkchkywpdk
.|.|. |..|||| ||. || .||.|| ..   ||||.|||.|...|   ...|||||| . ... |||||...|  .|.|.|.| |             
vaqkeinlkknryknilpydsarvkleviddipdsdylnasyipsfdne.kayiasqgpnaaslddfwrmvfqenvttiamvtklkegd...........

tetyggvtvtlhqseifadyeirtfilskaKRSGSRMVRQFHFTVWPDKGVPQYATAVLAFRRKVRALNPRDAGPVIVHCSAGVGRTGAYIVIDAMLEQA
                              |    | | ||||| ||||.||......| | ..|.|   . . |.|.||||||||||  | ||... .|
..............................kgddartvaqfhftewPdkdvpkhtssllkfikevkadfGqythpliihcsagvgrtgvvisidsvvaha

KKSRTVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVLEALTCGNTEIQSENYNQAMQKLASVN
||.| ||. |..  .|. ||.||||||||.||. |||| |   || |    . . .|.| .  
kktrmvdvfnfvtnirrkrpymvqtkeqyafiygavledllwrntlipvvhftdhlqdlstss
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 8-255 6.4e-66 217.6 In-house 48-293 (439) alignment 
Range on Protein: 8-255
Range on HMM: 48-293/439.0
NKNKNRYANIVAYDHSRVVLERVNGDEDSDYINASFIHGYDgTPRSFIASQGPLPPAFEGFWRMVWEQNSQSIVMLTNLVELGKtkchkYWPDKTETY-G
.. |||| ...|.||.||.|. . |   | |||| .|.||  ... .||.|||   . . |||.|.|...  |||||||||  |     ||| ..|.. |
dqtknrykdvgafdhtrvtlqeipgvphshyinanyikGyy.ddklyiatqgpkkettddfwrlviekktvtivmltnlvesyk.....ywpsdaevcyg

GVTVTLHQSEIFADYEIRTFILSKAKR--SGSRMVRQFHFTVWPDKGVPQYATAVLAFRRKVRALNP-RDAGPVIVHCSAGVGRTGAYIVIDAMLEQAKK
 ..|   .   . .| || | . . .      | | |||.. |||| ||  |. || | | . . |  .. |||.|||||||||||. | .|  ||| | 
diavrvdrnielpnyvirgfkvfnerdttekertvlqfhyiawpdknvpaqashvldflrainsandkeeygpvvvhcsagvGrtGtiialdialeqlkl

SRTVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVLEALTCGNTEIQSENYNQ
   |||.  .  |||.| .|||.  || ||. |||| .  |.. .. .....
enkvdikgivkvlrkqrkqmvqalcqyvfiynavledivyGdiavtidefkk
subfamily_CG7180_pd Subfamily CG7180 4-245 1.2e-65 216.1 In-house 38-294 (296) alignment 
Range on Protein: 4-245
Range on HMM: 38-294/296.0
RKPANKNKNRYANIVAYDHSRVVLERVNGDEDSDYINASFIHGYDgTPRSFIASQGPLPPAFEGFWRMVWEQNSQSIVMLTNLVELGKtKCHKYWPDK-T
 .  |..|||. ..| ||. |||||...|.|.||||||... ..   .. .|  ..|   . . |||.|........|.||.  .  | ....||| |  
lrkenreknrdvkvvPyDynRvvLekldGeeksdYinavyvdsfl.kkkeyivteapkketvdefWrlvydeeisavvvLtktfdfak.mypsywpnksk

ETYGGVTVTLHQSEIFADYEIRTFILSKA----------KRSGSRMVRQFHFTVWPD-KGVPQYATAVLAFRRKVRALNPRD-----AGPVIVHCSAGVG
| || . | . ... .|. .|||| | |                |.|..|..|.|.  . ||  ..|.. .||.|| .  .       |||.|..| |..
eqygeifveiveekqyanlkirtfkltkkivalteqekqvkaetRivklfqlteWeledkvPlstnalielrrrvrlwrekvdedpeegPvvvvssdGas

RTGAYIVIDAMLEQAKKSRTVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVLEALTCGN
|.|.|. ||| ||...|   ||. ...  ||..||..|...|.| .|   .|||. |. 
RsGvylaidanlelvekeeevdvFeavktlrrsRpqLvenveeYkyiYdvlleavlcnk
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 291-533 1.8e-65 216.0 In-house 42-286 (297) alignment 
Range on Protein: 291-533
Range on HMM: 42-286/297.0
EKSVGEKPQNLHKNRFSDIIALNSCRVMLHKEHADEESDYINAVFlhVRMERNAFIATQHPLQHTIEDFWRMVTDYDIGTIVMLNNLHEHDQEYPQYLPV
.. | ||  |..|.|...|.  .| ||.|.    | .|||.|| |  |.  .. .|.|| | . |..|||.|| |... ||||||...| |..  .| . 
pqtvaekkvnfeksRYkniLPydssRvkLaivnddpdsDyvnasf..vkgnkhrlittqmPmkatvadfWamvldeqvstivmlnddnerdkkcaryWsd

EGATKYGHIRVSLLSKQEKGDVISTKLKVTRNK--KTHEVRHLHHVSWPDKCIPE--VARSVLDLLDEVQASQQQCGNAPVLVQCSNGVGRSGTFCAISS
.| |..|.. | ||| .|.   |  .|.||..|  ... |.  ..|.|||| ...   |.|.|.|..||. . .|  ..|.|| |..|||| | ...| |
kgvttfGdvsvvllsvsereGfikrelevtkgkakarrvvkqyqfveWPdkaverkdsassllklisevrkdfsqnaegPllvhclaGvGrtgvlltids

VIERLKTEQVIDVFQVIKRIRANRPGAVESLTQYVFCYQIIQKYLDS
|. . | |. .|.|...|..| .||  |    || | |... ..| |
vvaeakrekevdifglvkklrqerpylvqtkeqykfvyvavlealls
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 260-540 1.9e-65 215.7 In-house 10-287 (287) alignment 
Range on Protein: 260-540
Range on HMM: 10-287/287.0
LASVNRKFQMTGYALEFQRLNSVTSREipaEEKSVGEKPQNLHKNRFSDIIALNSCRVMLHkehaDEESDYINAVFLHVRMERNAFIATQHPLQHTIEDF
..  ...   .|.   |. |..|| ||   .|  ..  .|| .|||...|.  .  ||.|.    .|. |||||||.    |..|||... |. .|. .|
fvakghakgnegfknqftvleqvtqre...devthniasqnkdknRltqilvpdnyrvllk....gehpdyinavfidgykekkafiiaesPmfntarnf

WRMVTDYDIGTIVMLNNLHEHDQEY-PQYLPVEGATKYGHIRVSLLSKQEKGDVISTKLKVTRNKK---THEVRHLHHVSWPDKC-IPEVARSVLdLLDE
|... |  . .|||| ...|.|.|   || | | .. .|. ...||... . ..|  ||.|....|   ...|.  .  .|...  ..| . ..| ...|
WkliddrnvtaivmlcqekendeevcyqyWpeeksvvlGeyniellneevnagyierklevknknkagdkqqvkqyqitnWdstgkvtepqtill.viee

VQASQQQCGNAPVLVQCSNGVGRSGTFCAISSVIERLKTEQVIDVFQVIKRIRANRPGAVESLTQYVFCYQIIQKYLDSFSDYANF
   .|.. ||....| ||..||||..|||.   |.. ||| |||||||.|. |  .||.|   .|| | ..|...|||||. |..|
myktqrkrgntsivvhCsdtvGrsamfcaaattinkckteGviDvfqvlksqriqkpgsvqtveqykfindivleyldsfetysdf
subfamily_PTPRB_pd Subfamily PTPRB 247-532 2.4e-65 215.5 In-house 6-286 (293) alignment 
Range on Protein: 247-532
Range on HMM: 6-286/293.0
EIQSENYNQAMQKLASVNrkfqMTGYALEFQRLNSVTSREipaeEKSVGEKPQNLHKNRFSDIIALNSCRVMLHKEHADEESDYINAVFLHVRMERNAFI
.|. |.... ..|... .     .... |...|..| . .    .... |...|  |||...|.. .  || |.. . ...|||||| ...    .. ||
piklekfeehvkkmkads....dlrfseeyeelkavgkdq....avkaaelavnraknrytnilpydhsrvkLaalkdesgsDYinanyipgynsprefi

ATQHPLQHTIEDFWRMVTDYDIGTIVMLNNLHEHDQ-EYPQYLPVE-GATKYGHIRVSLLSKQEKGDVISTKLKVTRNKKTHEVRHLHHVSWPDKCIPEV
||| || .|..|||||| .    .|||| .| |. .    .| | .  .. ||.|.|.|....|. | .  .||....|....||..|..||||  .|| 
atqGPlpetvddfWrmvwekkssiivmltqlvekgkvkCeeYWPadeepvlyGdikvtlvaeeeledwvirelkiekekeerkvrqyhftsWpdhgvPek

ARSVLDLLDEVQASQ-QQCGNAPVLVQCSNGVGRSGTFCAISSVIERLKTEQVIDVFQVIKRIRANRPGAVESLTQYVFCYQIIQKYLD
....||.. .|. .. ... ..|..| || ||||.||| |.  .......|...|.| .. ..| .|   | . .||.| .| ....| 
tktlldfvrtvreaiektaskrPivvhCsaGvGRtGtfialdrllqaieeedyvdifgivaelReeRnllvqtekqYifihqcvldllr
subfamily_PTPN12_pd Subfamily PTPN12 270-532 6.1e-65 214.0 In-house 8-278 (290) alignment 
Range on Protein: 270-532
Range on HMM: 8-278/290.0
TGYALEFQRLNSVTSREIPAE--EKSVGEKPQNLHKNRFSDIIALNSCRVMLHKEHADEESDYINAVFLHVRMERNAFIATQHPLQHTIEDFWRMVTDYD
  .| |||.| .....    .  ....|||..| .|||. ||.  .  ||.|.|.. .|.|||||| |..   .. ..||.| || .|..|||||. ...
eefakefqklkklsekykaekvysteagekeenvkknrykDilPydksrvelskieeeegsdYinanfikgvegkleyiaaqgPLpktlddfWrmiwekn

IGTIVMLNNLHEHDQEY-PQYLPVE--GATKYGHIRVSLLSKQEKG-DVISTKLKVTRNKKTHEVRHLHHVSWPDKCIPEVARSVLDLLDEVQASQQqCG
.  .||. .. | ..    .| | |   ....|...|.| ...    | .   |||...|....|. .|. .|||. .|. | |.|.|...|.  |.   
veivvmaCrevelgkkkCerYWpeegeeelefgefevtleeekavdddflirtLkveaqkesrkvyqfhYtaWPDhgvPssaksllelielvrelqe.se

NAPVLVQCSNGVGRSGTFCAISSVIERLKTEQV---IDVFQVIKRIRANRPGAVESLTQYVFCYQIIQKYLD
.||..| || |||| || .||  | | ||.|..   .|||... ..| .|. .| .  ||.. |. . ... 
daPlvvhCsaGvGrtGtiiaidyvrellkaekipeeldvfdlvlelrkqraalvqtkeqyelvykavaelvq
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 7-239 8.1e-65 213.5 In-house 19-262 (270) alignment 
Range on Protein: 7-239
Range on HMM: 19-262/270.0
ANKNKNRYANIVAYDHSRVVLERVNGDEDSDYINASFIHGYDGTPRSFIASQGPLPPAFEGFWRMVWEQNSQSIVMLTNLVELGKTKCHKYWPDKTET--
 .|. ||||.|.   ..||.||... |. . |||| ...|.|| ....||..|||| . . ||||.||.....|||.|.|.| |..|| .||| ....  
rgkklnRyadiLPsPatRvrleeleedsataYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkgrkkCerYWpaepkekv

---YGGVTVTlHQSEIFADYEIRTFILSKAKRSGSRMVrQFHFTVWPDKGVPQYAT------AVLAFRRKVRALNPRD--AGPVIVHCSAGVGRTGAYIV
   .| ..|.  .||  ..  |.| .  . | .  |.|  |... |||.|||. .        .|.  |.||. . .   |.|..|||||||||||  |.
kledgkikvl.alseekeegyiltrlrleekgeerrlv.HfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkaePllvHcsaGvgRtGtlia

IDAMLEQAKKSRTVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVLE
.| ...  .... ||. . . .|||||. .||. ||| |.. ||.|
lDiavrlLeetkkvdvlaiieelRkdRmalvqhpeqyeflykavve
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 269-531 2e-64 212.8 In-house 22-288 (325) alignment 
Range on Protein: 269-531
Range on HMM: 22-288/325.0
MTGYALEFQRLNSVTSReipaeEKSVGEKPQNLHKNRFSDIIALNSCRVMLHKEHADEESDYINAVFLHVRMERNAFIATQHPLQHTIEDFWRMVTDYDI
  |.| ||. | |. .       | |  ||.|  |||| ...||.  ||.|   . | .|||||| .|.  .... |.|.| || .||.|.||.| |.  
qdgfahefgllpsddgi.....akkvamkpenkaknrfknvvaldksrvvletkkddpssdyinasylrddkkkdvflaaqaPltatindlWrlvldWrc

GTIVMLNNLHEHDQEYPQYLPVE--GATKYGHIRVSLLSKQEKGDVISTKLKVTRNKK--THEVRHLHHVSWPDKCIPEVARSVLDLLDEVQASQQQ---
  .|.|| | . ...  .| | |   . ..| ..|.| . .|  | .  .|.| . ||  |  |. ... ||.|   ..   ... .|. |.| ...   
svvvvlneldlgkdrcavywpkemgksktfGglevklrtieeisdyvhrvldvkqvkkGetrsvkqfqlqswddmGvqkrpatlisilqlvkavservta

--CGNAPVLVQCSNGVGRSGTFCAISSVIERLKTEQVIDVFQVIKRIRANRPGAVESLTQYVFCYQIIQKYL
   . .|.|| ||.||||.|.| .. |..... .|  .|.|...|..|..||  ||.  ||...|. . ...
ntkastpilvhcsaGvGrtGvfislysalakvieesrvdifgfvkklrkdrpsmvetvdqyiliyealveay
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 264-537 5.3e-64 210.9 In-house 14-289 (290) alignment 
Range on Protein: 264-537
Range on HMM: 14-289/290.0
NRKFQMTGYALEFQRLNSVTSReipaEEKSVGEKPQNLHKNRFSDIIALNSCRVMLH--KEHADEESDYINAVFLHVRMERNAFIATQHPLQHTIEDFWR
... ...|.  .|..|.|  |     ..  ||  ..| ..|||..|.  .  |..|.   .| | . .||||....   |....|||| |...|. |||.
ghakgnegfrnqfkmldsgese....htvtvgltssnkllnRfanivvyddnritLrpisghkDCtneyinAcyikgykekkqyiatqgpvsntlvdFWk

MVTDYDIGTIVMLNNLHEHDQE-YPQYLPVEGATKYGHIRVSLLSKQEKGDVISTKLKVTRNKK---THEVRHLHHVSWPDKCIPEVARSVLDLLDEVQA
.. . ..  |||| |  |....   || | .....||.... ||. ..  . | .||.|. ...   ...| ...  .|...   .   ..| .. |.. 
liwqekvtiivmltniieegkvkCqqYWpdsdtkaygefsikllneetlneyierklevknknsagakqsvtqyqitnwdstgkvtnpqtillvieemyk

SQQQCGNAPVLVQCSNGVGRSGTFCAISSVIERLKTEQVIDVFQVIKRIRANRPGAVESLTQYVFCYQIIQKYLDSFSDY
 | . || ...| ||..||||..|||.   |.. |||.|||||||.|. |  .|| |..  || . .||. .|||||. |
tqrkrgntsivvHCSdtvgrsavfcaaattinkcktegvidvfqvlksqRiqkpgsvqtvqqyqgifqivltyldsfety
0037934 (Phosphotyrosine protein) phosphatases II 294-531 2.1e-63 209.4 In-house 4-242 (243) alignment 
Range on Protein: 294-531
Range on HMM: 4-242/243.0
VGEKPQNLHKNRFSDIIALNSCRVMLhkehadEESDYINAVFLHVRmeRNaFIATQHPLQHTIED----FWRMVTDYDIGTIVMLNNLHEH-DQEYPQYL
.. .|.||.|||.|||....  || |      | |||||| .  |   .. .||||.||..|.||    ||||. ...|..||||..| |.  . ..|| 
iallpenlsknrysdilpydhsrvkl......egsdyinanliyvt..pr.liatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqyw

PveGATKYGHIRVSLLSKQEKGDVISTKLKVTR---NKKTHEVRHLHHVSWPDKCIPEVARSVLDLLDEVQASQQQ-------CGNAPVLVQCSNGVGRS
|  | . ||...| ||| ....|.. ..|....   .. |..|.|.|...||| ..|.   ..||.||||.. ...        .. |||| || ||||.
p..gevtygdftvtllseehlddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRt

GTFCAISSVIERLkteQvIDVFQVIKRIRANRPG-AVESLTQYVFCYQIIQKYL
||..|.  ....|   . .|.....|..|. ||| ||... ||.|.|......|
Gtliaaylmllll...g.vdleeavkllreqRpgkavqtpsqyrflyeallell
subfamily_PTPRG_pd Subfamily PTPRG 270-533 1.1e-62 207.1 In-house 19-289 (563) alignment 
Range on Protein: 270-533
Range on HMM: 19-289/563.0
TGYALEFQRL-NSVTSREIPAEEksvGEKPQNLHKNRFSDIIALNSCRVMLHKEHADEES-DYINAVFLHVRMERNAFIATQHPLQHTIEDFWRMVTDYD
.|.. ||. | . ..|....||     .||.| .||| ..|.| .. || |..    ... ||||| ...     .||||||.||..|..|||||. .  
igfseefealqsetiskdldaeh...sqkpenkrKnRylnivaydrsRvklsplpgkkkklDYinAnyidGyqkskafiatqgplkdtfddFWrmiWeqn

IGTIVMLNNLHEHDQ-EYPQYLPVEGATKYGHIRVSLLSKQEKGDVISTKLKVTR-------N-KKTHEVRHLHHVSWPDKCIPEVARSVLDLLDEVQAS
  .|||. || |. . . ..| | ... .||...| | ... .    . .|..         . .. ..||. |  .|||.. || .  ||      .|.
vaiivmitnlvergrrkcdvYWPkdesetygalqvtlieeevlalytvrtlviknlklkkkkqcdteklvrqyhytkWPdhgvPehslpvLifvkkssaa

QQQcGNAPVLVQCSNGVGRSGTFCAISSVIERLKTEQVIDVFQVIKRIRANRPGAVESLTQYVFCYQIIQKYLDS
...    |..| ||.||||.||.............|....||...|.|||.|.  |..  ||.| ...... . |
nka.eaGPivvHcsaGvgrtGtyivldtllkqiqqenavnvfgflkhiraqRnflvqteEqYiflhdalleaias
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 294-531 1.5e-62 206.3 In-house 37-276 (515) alignment 
Range on Protein: 294-531
Range on HMM: 37-276/515.0
VGEKPQNLHKNRFSDIIALNSCRVMLHKEHADEESDYINAVFLHVRMERNAFIATQHPLQHTIEDFWRMVTDYDIGTIVMLNNLHEHDQE-YPQYLPV--
| ..  | .|||. .|. ..| || |   . . .|||.|| ...     .|.||.| |.. ...||||.| .... ||.|...|.| |.    .| |   
vaqeeinfkknryknilPydsvrvklevindnPhsdyfnasyipsfdndkayiasqgPnkasvddfWrlvlqenvttiamvtklkegdkikcgkyWPdkp

EGATKYGHIRVSLLSKQEKGDVISTKLKVTRNKKTHEVRHLHHVSWPDKCIPEVARSVLDLLDEVQASQQQCGnAPVLVQCSNGVGRSGTFCAISSVIER
  . |.|.|.|.|.| .  .. |  ||.|....... |   |   |||| .|. ..|.| |. ||.|...|    |... || |||| | ...| ||. .
gdsvkfGsikvelvsleactggikrkltvlkgddsrtvtqfhfteWPdkGvpkhtssllklikevkadhgqyt.hpliihcsaGvGrtGvvisidsvvah

LKTEQVIDVFQVIKRIRANRPGAVESLTQYVFCYQIIQKYL
 || ...|||.... ||..||  |    || | |.... .|
akttrmvdvfnfvtnirqkrpylvqtqeqyafiygavledl
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 294-527 2e-62 205.9 In-house 43-275 (315) alignment 
Range on Protein: 294-527
Range on HMM: 43-275/315.0
VGEKPQNLHKNRFSDIIALNSCRVMLHKEHADEESDYINAVFLHVRMERNAFIATQHPLQHTIEDFWRMVTDYDIGTIVMLNNLHEHDQEYPQ-YLPVEg
|  | .| .|||. .||| .  || |     |..|||.|| |.     .. .||.| |.  ...||||.| ..|||.||||.|| | ...  . | | . 
vakkienkqknryiniiaydksrvqlpllendphsdyvnanfidGynkkrryiaaqgpnvasvkdfwrlvfeedigkivmltnlvegekrkaekywpdk.

ATKYGHIRVSLLSKQEKGDVISTKLKVTRNKKTHEVRHLHHVSWPDKCIPEVARSVLDLLDEVQASQQQCGnAPVLVQCSNGVGRSGTFCAISSVIERLK
   ||.| |.. |.. . ..    | |. ... .||  ||. ||||  .|. . ....|   |.  ...   ....| ||.||||.|||.....|.....
kviyGkitvtrkseevnteytvrtlsvvfgdnirevvqlhytswpdmgvpkytiplmnlirtvkqhhtnsv.gaivvhcsaGvGrtGtfitldavldqae

TEQVIDVFQVIKRIRANRPGAVESLTQYVFCYQII
.|..|||...|...|.|| ..|... || | |...
aenaidvynfitgvrqnrikmvqvaeqyqfiydal
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 287-532 4.7e-61 201.3 In-house 31-278 (315) alignment 
Range on Protein: 287-532
Range on HMM: 31-278/315.0
IPAEEKSVGEKPQNLHKNRFSDIIALNSCRVMLHKEHADEESDYINAVFLHVRMERNAFIATQHPLQHTIEDFWRMVTDYDIGTIVMLNNLHEHDQ-EYP
 .. .. |. ...| .|||. .|. |.| ||.|     . .|||||| ...   . .|.||.| ||. ...|||||| .... ||||.....| |. .  
PdiyrqrvaretinfkknryknilPldsarvkleviddsPdsdyinasyiksvdddkayiasqgPlkasvddfwrmvlqekvttivmvtkkqegdkikcr

QYLPV--EGATKYGHIRVSLLSKQEKGDVISTKLkVTR-NKKTHEVRHLHHVSWPDKCIPEVARSVLDLLDEVQASqQQCGNAPVLVQCSNGVGRSGTFC
|| |     ....| |.|.||| .  .| .  || |||  .... |   .   |||| ... . |.| |. ||.|. ..  . ..|| || ||||.| ..
qywPdrkadsvefGsikvellsleadtdgvarkl.vtrkseesrtvtqfqftewPdkGvdkqtssllklikevkad.ngkkefsllvhcsaGvGrtGvvi

AISSVIERLKTEQVIDVFQVIKRIRANRPGAVESLTQYVFCYQIIQKYLD
.| .|....| ....|||...| .||.||  | .  .| | |......| 
sidevvaqikrtrsvdvfnfvknlrakrpylvqteeeyafiydavledll
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 263-533 9.6e-60 197.1 In-house 8-278 (281) alignment 
Range on Protein: 263-533
Range on HMM: 8-278/281.0
VNRKFQMTGYALEFQRLNSVTSREIpAeekSVGEKPQNLHKNRFSDIIALNSCRVMLHKEHADEESDYINAVFLHVRMERNAFIATQHPLQHTIEDFWRM
 ... . .|.. |.. |...  ..  |   .  ....| .|||.|.|.| .  || ..........||||| |.    . ...|||| |. .....||.|
qlsqndnaGfieeyeklaaigvdnt.a...taskadenvlknrYsnivaYDatrvkvtpneenkntDYinanfvpgykgekeyiatqgPvPaslvafWqm

VTDYDIGTIVMLNNLHEHDQ-EYPQYLPVEG-ATKYGHIRVSLLSKQEKGDVISTKLKV-TRNKKTHEVRHLHHVSWPDKCIPEVARSVLDLLDEVQASQ
| .... .|||. .  | ..    .| | .  ..|||...|. ....||   |. |.|. ... .| ||..|....|||. .|. .. .|.  .||.  .
vweqkvsaivmvtreieagklkChrYWPddnselkygdvtvkstaeeekatyierkfkleresgetreveqlaytaWPdhGvPattkellefrkevlklt

QQCGNAPVLVQCSNGVGRSGTFCAISSVIERLKTE-QVIDVFQVIKRIRANRPGAVESLTQYVFCYQIIQKYLDS
..  .||... || ||||.||. |.  .......| . .|| .|.. .| .|   | ...|| | |... ..|| 
ekktkaplvihCsaGvGrtGtyialDrlvkaveaeleeldvkavvaelrkernlmvqtvvqyefvykavldaldk
subfamily_PTPN23_pd Subfamily PTPN23 8-240 2.1e-59 195.7 In-house 43-279 (288) alignment 
Range on Protein: 8-240
Range on HMM: 43-279/288.0
NKNKNRYANIVAYDHSRVVLErvngDEDSDYINASFIHGYDGTPRSFIASQGPLPPAFEGFWRMVWEQNSQSIVMLTNLVELGKTKCHKYWP---DKTET
. .|||. .|. |||.||.|.    ..  |||||||...   .  .|||.|.||...   ||.||.|| |. ||||..  ||||.|...|||   ..|..
yseknrsrdilPyDhnRvklr....gskDDYinAsfvkdlspgcPdfiatqaPlqstlnDFWlmvyeqkssviVmllskeelgkpkvdrYwPedkgetvk

YGGVTVTLHQSEIFADYEIRTFILSKAKRSGSRMVRQFHFTVWPDKGVPQYATAVLAFRRKVRA----LNPRDAGPVIVHCSAGVGRTGAYIVID-AMLE
.| ..|||.. .    .  |...|.  . .  ..|.  ..| ||. |||.    .|.|  .|..     . .   |..|||||||||||.. ..  |. |
fgdlsvtlksvretethvervlkletldadavksvshlqltsWpelGvPasPetllqfldevesayeavqrksktPlvvhCsaGvgRtgvfalvyaavre

QAKKSRTVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVLEA
  |.   .|| . .  ||..| .|||.|||. |  .|||||
lekgnglldiiqvvsrlreqRrfmvqekeqlkfsyeavlea
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 264-537 1.3e-58 193.8 In-house 26-298 (319) alignment 
Range on Protein: 264-537
Range on HMM: 26-298/319.0
NRKF--QMTGYALEFQRLnsvTSREIPAEEKSVGEKPQNLHKNRFSDIIALNSCRVMLHKEHADEESDYINAVFLHVRMERNAFIATQHPLQHTIEDFWR
...|  ..| .  ||.|.   . . ..  ...  . .||  |||. .|.| .  .| |..    | |||||| |.     .. .||.| ||. |..||||
ksdfdddltklevefrra...cklgvnladqtfanldqnkdknriinilafdknvvklerliGeefsdyinasfvtGyqrkdkyiaaqGPldntladfWr

MVTDYDIGTIVMLNnlhehDQEYPQYLPVEGATKYGHIRVSLLSKQEKGDVISTKLKVTR---NKKTHEVRHLHHVSWPDKCIPEVARSVLDLLDEVQ-A
|. .|.. |||.|       .   || | ..  |...  |.. | .|  . .  ......   .|   ...  |   |||.  |. .  .. |.. |.  
miweyncstivllt.....kdkcsqywplkivikeerfkvkvdsveetaeyvvrdielsedgkekdirkitqfhflGwpdvGvpdypsdlmrlvkkvrhl

SQQQCGNAPVLVQCSNGVGRSGTFCAISSVIERLKTEQVIDVFQVIKRIRANRPGAVESLTQYVFCYQIIQ-KYLDSFSDY
 ... ..|...| || ||||.|.. ..  ...|.| |. .||..... .| .|.  |..|.|| |.|  .  ..| ..|| 
tskenhranivvhcsaGvGrtGvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalleehlfghsdv
subfamily_PTPN6_pd Subfamily PTPN6 246-533 3.1e-58 192.2 In-house 2-299 (306) alignment 
Range on Protein: 246-533
Range on HMM: 2-299/306.0
TEIQSENYNQAMQKLASVNRKFQMTGYALEFQRLNSVTSREIpaEEKSVGEKPQNLHKNRFSDIIALNSCRVMLHkEHADEESDYINAVFLH--VRMERN
|.. ... .| ...|   . ... .|.  ||..|.   ...    ... |.||.| .|||.  |.  .  ||.|. |.   .|||||| ...  |. ...
tsllakeieqrvselekeeeslekagfeeefeelqqeeakkl..lsrkegakpenkeknryknilPfDhtrvilk.epsvpgsdyinanyikkevkgsdk

AFIATQHPLQHTIEDFWRMVTDYDIGTIVMLNNLHEHDQ-EYPQYLPVEGA-TKYGHIRVSLLSKQEKGDVISTKLKVT---RNKKTHEVRHLHHVSWPD
..||||  |..|..|||||| . .   |||. .  |. .    .| | | . ..||.|.|. .|.... | |  .|.|.   ..|...||...|. ||||
syiatqgclettvsdFWrmvwqensrvivmttkevErgkekCarYWPdeeekeeyGkisvtnvseksladYilRelsvskkkkkkeerevfqyhfksWPd

KCIPEVARSVLDLLDEVQASQQQCG---NAPVLVQCSNGVGRSGTFCAISSVIERLKT---EQVIDVFQVIKRIRANRPGAVESLTQYVFCYQIIQKYLD
. .|.    |||.|..|.. |...    . |..| ||.|.|| |||  |  ... ...   .  ||. ...| .|. | | |   .|| | |..|.||..
hgvpkdpgavLdfledvnrkqeeleeaeagpivvhCsaGiGRtGtfiviDillkliekkgldadidiqklvksvreqrsglvqteqqykfvykaikkyie

S
.
t
subfamily_PTPN9_pd Subfamily PTPN9 288-530 8.8e-58 190.7 In-house 30-289 (297) alignment 
Range on Protein: 288-530
Range on HMM: 30-289/297.0
PAEEKSVGEKPQNLHKNRFSDIIALNSCRVMLHKEHADEESDYINAVFLHVRMERNAFIATQHPLQHTIEDFWRMVTDYDIGTIVMLNNLHEHDQ-EYPQ
.. .  . ... ||.|||..|.. ... ||.| |.. ||.|||||| |.    ...|||||| ||..|..|||||| . .. .|||   . |. .    |
veGtflasklranleknrytdvlcydetrvvlakvdedeasdyinanfvdGykqkkafiatqGplkktvsdfWrmvWeqevlvivmttrvvergrlkcgq

YLP--VEGATKYGHIRVSLLSKQEKGDVISTKLKVT--RNKKTHEVRHLHHVSWPDKCIPEVARSVLDLLDEVQASQQ------------QCGNAPVLVQ
| |   | ....|...|| .. .|. |   ..|...  ..... .| |   .||||  .|. | |.||.|..|.  |             .. . |..| 
yWpleeessaefgdlsvsnveveeeedykvrvleiknvkteesrkvthfqflsWPdyGvPssaaslldvlekvrekqalavkelgdewkghpsgPPivvh

CSNGVGRSGTFCAISSVIERLKTEQVIDVFQVIKRIRANRPGAVESLTQYVFCYQIIQKY
|| |.||.|||...   ..||......||....|..|. |  ..    ||.|||. .  |
csaGiGrtGtfitldiclsrleevgtvdvvetvkllrtqrafsiqtpeqyefcylavley
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 283-537 1.6e-57 190.2 In-house 8-262 (284) alignment 
Range on Protein: 283-537
Range on HMM: 8-262/284.0
TSREIPAEEKSVGEKPQNLHKNRFSDIIALNSCRVMLHKEHADEESDYINAVFLHVRMERNAFIATQHPLQHTIEDFWRMVTDYDIGTIVMLNnlhehDQ
. . ... ...  . .||  |||. .|.| .  .| |..    | |||||| |.     .. .|||| ||. |..|||||. .|.. |||.|      ..
cklgvngtdqtfanldqnkdknrighilafdknvvklerliGeefsdyinasfitGyqrkdkyiatqGPldntladfWrmiweyncstivllt.....kd

EYPQYLPVEGATKYGHIRVSLLSKQEKGDVISTKLKVTR---NKKTHEVRHLHHVSWPDKCIPEVARSVLDLLDEVQ-ASQQQCGNAPVLVQCSNGVGRS
   || | ..  |... .|.. | .|  . .  ......   .|.  ..|  |   |||.  |. .  .. |.. |.  .... ..|...| || ||||.
kcsqywplkivikeerfkvkvdsveeseeyvvrdielsedgkekdirkirqfhflgwpdvgvpdypsdlmrlvkkvrhltskenhranivvhcsagvgrt

GTFCAISSVIERLKTEQVIDVFQVIKRIRANRPGAVESLTQYVFCYQIIQ-KYLDSFSDY
|.. ..  ...|.| |. .||..... .| .|.  |..|.|| |.|  .  ..| ..|| 
gvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalleehlfghsdv
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 7-247 5.2e-57 187.8 In-house 39-299 (301) alignment 
Range on Protein: 7-247
Range on HMM: 39-299/301.0
ANKNKNRYANIVAYDHSRVVLERVNG--DEDSDYINASFIHGYDGTpRSFIASQGPLPPAFEGFWRMVWEQNSQSIVMLTNLVELGKTKCHKYWPD---K
.||. ||. ||. ||. |..|.  .       .|||||.|.||  . . |||.|||.      |||..|..  .||||.||| |  |.||..|||.   .
enkalnrfknitvyddnriilkpkpnldlcqreyinasyidgysek.kkfiaaqgpmkktlvdfWrliwqekpvsivmvtnlkegtkskceqywpnseae

TETYGGVTVTLHQSEIFADYEIRTFILSKA---------------KRSGSRMVRQFHFTVWPDKGV-PQYATAVLAFRRKVRALNPRDAGPVIVHCSAGV
.|..| .||||... .. |. || . .                  ..  |. | |.. | ||. || ....| . .    . . .  . |||.||||..|
seefgpftvtlvneqvyPdfvirqlnvkiqdgsnngyierkfkvksdksswdvlqlqvtdWpqdGvvreprtvLqviddvihrqqkigggpvvVHCSdtV

GRTGAYIVIDAMLEQAKKSRTVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVLEALTCGNTE
.|.| |. ..  |||.|    ||. .   |.|. .| .|.| |||..|. .. . |.. .|.
srsGvYcsvsiglEQckaegVVdvfqvtkavrrskpgaVtTLeqytsiydvidmylqlnsty
subfamily_PTPN14_pd Subfamily PTPN14 2-241 7.3e-57 187.6 In-house 43-296 (300) alignment 
Range on Protein: 2-241
Range on HMM: 43-296/300.0
AARKPANKNKNRYANIVAYDHSRVVLERVNgDEDSDYINASFIHGY-DGTPRSFIASQGPLPPAFEGFWRMVWEQNSQSIVMLTNLVELGKTKCHKYWPD
.|. | |..|||. ... |...|| |   . .....||||| |.    |. ||.|..||||. . . ||.|||||. | |||||.  | ||.|..||.|.
taklpenaeknrfkdvlPyednrvelsptk.enstgyinassikvsvggkersyivaqgPleltvqdfWqmvWeqgvqlivmlteeeedgkeksfkyfPk

K-----TETYGGVTVTLHQSEIFADYEIRTFILSKAKRSGSRMVRQFHFTVWPDKGVPQYATAVLAFRRKVRALNPR---------DAGPVIVHCSAGVG
.     | ..|   || . ||    .  ... |     .  | |  . .| |||.|||.  .  | . ..|...  .            ||.||||||||
leskkktvefgkfkvttkfsedsdsvittglklkhlpskeertvwhlqytDWpdhgvPeDvkgflsyLeevqsvrrktnseveskeskPPvlvhCsaGvG

RTGAYIVIDAMLEQAKKSRTVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVLEAL
|||  |. | ...  .. ...||.. |  ||. | ..|||  || |....... |
rtGvlilsdlliatlehneeidikkvlarLreqrmllvqtlaqYkfvYkvlikyl
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 297-532 7.7e-57 187.5 In-house 25-269 (274) alignment 
Range on Protein: 297-532
Range on HMM: 25-269/274.0
KPQNLHKNRFSDIIALNSCRVMLHKEHADEE-SDYINAVFLH-VRMERNAFIATQHPLQHTIEDFWRMVTDYDIGTIVMLNNLHEHDQ-EYPQYLPVEGA
 . . .|||. .|.  .  ||.|..|....| |.|||| ...  . | .|..||| ||..|..|||||.   ..  |||| .|.|...    .| | .  
vfgsqtknryktilPnensrvllesessededssyinanyikGydeeskayvatqGPlpntvadfWrmiyqeevqvivmltklkeaneqkCavyfPdaed

T----KYGHIRVSLLSKQEKGDVISTKLKVTRNKKTHEVRHLHHVSWPDKCIPEVARSVLDLLDEVQASQQQCGN--APVLVQCSNGVGRSGTFCAISSV
.    .||.. .   .. |. |   .|| .   .....| |  . .|||.  |. |...|||..||. |...  .  |||.| || |.|| | | |||  
yeiserygdveikvekiverndysvrklvlkylerersvkhywytdWPdhksPddantlldlvleveesreeenaklapvvvhCsaGiGrtGcfiaisia

IERLKTEQVIDVFQVIKRIRANRPGAVESLTQYVFCYQIIQKYLD
. .|. |.|.||....  .| .| | |..  || . .... .|| 
vrqlreeivvdvlkivcnlrldrGGmvqtseqyelihralclylk
subfamily_CG7180_pd Subfamily CG7180 268-531 2.3e-56 185.6 In-house 11-290 (296) alignment 
Range on Protein: 268-531
Range on HMM: 11-290/296.0
QMTGYALEFQRLNSVTSReIPAEEKSVGEKPQNLHKNRFSDIIALNSCRVMLHKEHADEESDYINAVFLHVRMERNAFIATQHPLQHTIEDFWRMVTDYD
..  . .|.. .  .|.| .  ..   | . .|. |||  ...  .  ||.|.| . .|.|||||||.    .  ...| |. | ..|...|||.| | .
krrkfrveyklelkltpr.leigdCagglrkenreknrdvkvvPyDynRvvLekldGeeksdYinavyvdsflkkkeyivteapkketvdefWrlvydee

IGTIVMLNNLHEHDQEYPQYLPVEGATKYGHIRVSLLSKQEKGDVISTKLKVTRN------------KKTHEVRHLHHVSWPD-KCIPEVARSVLDLLDE
| ..|.| .  .  . ||.|.| .. ..||.| | ......  .. . ..|.|..             .|  |....   |.  . .| .. ....|.  
isavvvLtktfdfakmypsywpnkskeqygeifveiveekqyanlkirtfkltkkivalteqekqvkaetRivklfqlteWeledkvPlstnalielrrr

VQASQQQC----GNAPVLVQCSNGVGRSGTFCAISSVIERLKTEQVIDVFQVIKRIRANRPGAVESLTQYVFCYQIIQKYL
|.  ...      ..||.| .|.|..||| ..||   .| .. |. .|||. .|..| .||. ||. ..| ..|.......
vrlwrekvdedpeegPvvvvssdGasRsGvylaidanlelvekeeevdvFeavktlrrsRpqLvenveeYkyiYdvlleav
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 2-238 3.5e-56 185.1 In-house 32-274 (287) alignment 
Range on Protein: 2-238
Range on HMM: 32-274/287.0
AARKPANKNKNRYANIVAYDHSRVVLErVNGDEDSDYINASFIHGYDGTpRSFIASQGPLPPAFEGFWRMVWEQNSQSIVMLTNLVELGKTKCHKYWPDK
|| . |. .|||||... .|..||.|   .|.  |||||| .. .|     .|||.|||.. .   |||.|.|..| |....|  || .. ||.||||..
aaeelaavkknryadvlPiddtrvlls.aegelGsdyinanyvasytdd.eafiaaqgPiaatvrdfwravletrsasvitmtreveearlkcykywPer

TE--TYGGVTVTL-HQSEIFADYEIRTFILSKAKRSGSRMVRQFHFTVWPDKGVPQYATAVLAFRRKV-----RALNPRDAGPVIVHCSAGVGRTGAYIV
      || .|.|  ..    .| .|.. | ...   .|.|.|...  ||||...  | ... |  .|      | .  ..||..||...|.||.| .. 
evPmrvGGysvvlldydikePeygvralrlidletrearvvkqldllswPdkvlaPtavglirfvldvkqhielardasevGPlvvhddvGiGrsGilla

IDAMLEQAKKSRTVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVL
. ..... ..   ||. . .| ||. |  .||.  |. ..  |. 
tlvlvsrledlGrvdvaavvirlreyraalvqavvqlrllyealv
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 289-539 1e-55 183.6 In-house 29-301 (301) alignment 
Range on Protein: 289-539
Range on HMM: 29-301/301.0
AEEKSVGEKPQNLHKNRFSDIIALNSCRVMLHKEHA--DEESDYINAVFLHVRMERNAFIATQHPLQHTIEDFWRMVTDYDIGTIVMLNNLHEH-DQEYP
 .. .|| . .| . ||| .|  ..  |..|.....    . .|||| ...   |...|||.| |...|. ||||.. ..   .|||. ||.|   ..  
dksctvglseenkalnrfknitvyddnriilkpkpnldlcqreyinasyidgysekkkfiaaqgpmkktlvdfWrliwqekpvsivmvtnlkegtkskce

QYLPVEG--ATKYGHIRVSLLSKQEKG-----------------DVISTKLKVTRNKKTHEVRHLHHVSWPDKCIPEVARSVLDLLDEVQASQQQCGNAP
|| |      ...|.. | | ..|                      |  |.||...|....|  |. ..||.  .    | ||  .|.|   ||. | .|
qywpnseaeseefgpftvtlvneqvyPdfvirqlnvkiqdgsnngyierkfkvksdksswdvlqlqvtdWpqdGvvreprtvLqviddvihrqqkigggp

VLVQCSNGVGRSGTFCAISSVIERLKTEQVIDVFQVIKRIRANRPGAVESLTQYVFCYQIIQKYLDSFSDYAN
|.| ||..|.|||..|..|  .|  | | |.|||||.|..| ..||||  | ||.. |..|..||   | |||
vvVHCSdtVsrsGvYcsvsiglEQckaegVVdvfqvtkavrrskpgaVtTLeqytsiydvidmylqlnstyan
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 7-251 2.8e-55 182.2 In-house 32-276 (283) alignment 
Range on Protein: 7-251
Range on HMM: 32-276/283.0
ANKNKNRYANIVAYDHSRVVLERVNGdedsDYINASFIH--GYDGTPRSFIASQGPLPPAFEGFWRMVWEQNSQSIVMLTNLVELGKTKCHKYWPDK-TE
 ||.|||. .||..|  || |.  .     |||||.||     .   . .|..|.||  .   ||.||....  .|||||.| |  . || .||| . .|
enkrknrnqeivpadqwrvelksesr....dyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfdekitaivmltklqedlrikCsqyWPkrGse

TYGGVTVTLHQSEIFADYEIRTFILSKAKRSGSRM-VRQFHFTVWPDKGVPQYATAVLAFRRKVRALNPRDAGPVIVHCSAGVGRTGAYIVIDAMLEQAK
 ||  ||||..      . |. ..| .   . | . .  . .  | . |      ... | . .   .    ||..||||.|.|||...| . | ...|.
dyGeftvtlrkettsnsfiikelllrvnssakstlllahyqvidWleygeqaiinslvkfnkvislqteskkgPivvhCstgiGrtavfiaasasvkdal

KSRTVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVLEALTCGNTEIQSE
 .  ||. . .  .|..|. .|||..|| ..| .|||   ||.|.|   
tesvvdvfavvkimreqrmmavqtldqyklvhelvleqalcgdtqiaav
subfamily_PTPN23_pd Subfamily PTPN23 269-531 1.1e-54 180.2 In-house 14-280 (288) alignment 
Range on Protein: 269-531
Range on HMM: 14-280/288.0
MTGYALEFQRLNSVTSREipAEEKSVGEKPQNLHKNRFSDIIALNSCRVMLHkehaDEESDYINAVFLH-VRMERNAFIATQHPLQHTIEDFWRMVTDYD
 |.   .|. |..   .|  |...|.     . .|||. ||.  .. ||.|.    ... ||||| |.. .      ||||| ||| |. |||.|| .  
ktaldkkfkeleqkqdke..arkrsiaiaklyseknrsrdilPyDhnRvklr....gskDDYinAsfvkdlspgcPdfiatqaPlqstlnDFWlmvyeqk

IGTIVMLNNLHEHDQE-YPQYLPVE--GATKYGHIRVSLLSKQEKGDVISTKLKVTRN--KKTHEVRHLHHVSWPDKCIPEVARSVLDLLDEVQA---SQ
  .|||| . .| ...   .| | .   ..|.|...|.| |..| . ..  .||.. .  .....|.||.  |||.  .|.   ..|..||||..   ..
ssviVmllskeelgkpkvdrYwPedkgetvkfgdlsvtlksvretethvervlkletldadavksvshlqltsWpelGvPasPetllqfldevesayeav

QQCGNAPVLVQCSNGVGRSGTFCAISSVIERLKTE-QVIDVFQVIKRIRANRPGAVESLTQYVFCYQIIQKYL
|.  ..|..|.|| ||||.|.|. . .... |...  ..|. ||..|.|..|   |.  .|. |.|... .. 
qrksktPlvvhCsaGvgRtgvfalvyaavrelekgnglldiiqvvsrlreqRrfmvqekeqlkfsyeavleaa
0051429 (Phosphotyrosine protein) phosphatases II 36-260 4.3e-54 179.3 In-house 4-243 (272) alignment 
Range on Protein: 36-260
Range on HMM: 4-243/272.0
SDYINASFIHGYdGT---PRSFIASQGPLPPAFEGFWRMvWEQNSQSIVMLTNLVELGKTKCHKYWP-------------DKTETYGGVTVTLHQSEIFA
|.||||... || |    |. ...|.||||   ..|||. .|..  .||.|....|.|. ||..|||             . | .|| ..|||.. |.. 
sgyiNardvggy.grvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseelll

DYEIRTFILSKA-KRSGSRMVRQFHFTVWPDKGVPQYAtaVLAFRRKVRAlnprdAGPVIVHCSAGVGRTGAYIVIDAMLEQAKKSRTVD--------IR
|| .|...|..  . . .|.|...|.| ||| |||| |  .|.. . ...      |||.||||||..||| ..... .|..  ..  ||        ..
dyilrellltlllsagearevmhlhytdwpdhgvpqea..llellellld.....ggpvlvHCsaGkdRTGtvvallllllgvsletivddYlltnlyle

NYLIALRKDRPHMVQTKEQYSFIHSAVLEAlTCGNTEIQSENYNQAMQKL
...  ||. ||..||| ||| |.. |.||.  .. .... | ...|.. .
eaveelraqrpgavqteeqylflyeallel.lrsllsvraeyllaaldai
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 290-532 7.6e-53 174.2 In-house 10-265 (270) alignment 
Range on Protein: 290-532
Range on HMM: 10-265/270.0
EEKSVGEKPQNLHKNRFSDIIALNSCRVMLHKEHADEESDYINAVFLH-VRMERNAFIATQHPLQHTIEDFWRMVTDYDIGTIVMLNNLHEHDQEY-PQY
.|... |  .. . ||. ||.     ||.|.... |... |||| ... .  |....||.. ||. |...||||. .    .|||. .|.|. ..   .|
sesdlpeaargkklnRyadiLPsPatRvrleeleedsataYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkgrkkCerY

LPVEG----ATKYGHIRVSLLSKQEKGDVISTKLKVTRNKKTHEVRHLHHVSWPDKCIPEVAR------SVLDLLDEVQASQQQCGNA-PVLVQCSNGVG
 | |     ....|.|.|  ||.. .   | |.|..... ..... | ....|||. .|. .       ..| .| .|..|...  .| |.|| ||.|||
WpaepkekvkledgkikvlalseekeegyiltrlrleekgeerrlvHfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkaePllvHcsaGvg

RSGTFCAISSVIERLKTEQVIDVFQVIKRIRANRPGAVESLTQYVFCYQIIQKYLD
|.||. |.  ... |.... .|| ..|...| .|.  |.   || | |. ...| .
RtGtlialDiavrlLeetkkvdvlaiieelRkdRmalvqhpeqyeflykavveyae
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 270-527 4.1e-52 171.8 In-house 6-262 (283) alignment 
Range on Protein: 270-527
Range on HMM: 6-262/283.0
TGYALEFQRLNSVTsreIPAEEKSVGEKPQNLHKNRFSDIIALNSCRVMLHKEHAdeesDYINAVFLHVRM---ERNAFIATQHPLQHTIEDFWRMVTDY
... | ...|. ..   .|  .  .    .| .|||. .|.. .  || |. |      |||||||. |     . . .|..| ||..|. |||.|| | 
nnnklfrevlkrls...vpdldadiasadenkrknrnqeivpadqwrvelksesr....dyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfde

DIGTIVMLNNLHEHDQE-YPQYLPVEGATKYGHIRVSLLSKQEKGDVISTKLKVTRN---KKTHEVRHLHHVSWpDKCIPEVARSVLDLLDEVQASQQQC
.| .|||| .| |  ..   || | .|. .||   |.|     .   |  .| .  |   |.|  . |   . |  .. ..     |  .. |.. |.. 
kitaivmltklqedlrikCsqyWPkrGsedyGeftvtlrkettsnsfiikelllrvnssakstlllahyqvidW.leygeqaiinslvkfnkvislqtes

GNAPVLVQCSNGVGRSGTFCAISSVIERLKTEQVIDVFQVIKRIRANRPGAVESLTQYVFCYQII
 ..|..| ||.|.||...|.|.|. .. ..|| |.|||.|.| .| .|..|| .| || . ....
kkgPivvhCstgiGrtavfiaasasvkdaltesvvdvfavvkimreqrmmavqtldqyklvhelv
0041856 (Phosphotyrosine protein) phosphatases II 8-247 8.7e-51 167.4 In-house 1-177 (182) alignment 
Range on Protein: 8-247
Range on HMM: 1-177/182.0
NKNKNRYANIVAYDHSRvvlervngdeDSDYINASFIHGYDGTPRsFIASQGPLPPAFEGFWRMVWEQNSQSIVMLTnlvelgktkCHKYWPDKTetygg
|..|||| .|. |||||          |.|||||... |.  . | ||| ||||.  .. |.||..|.. ..||.||         .. |||..      
nldknrysdilpydhsr..........dldyInanlylgslpatr.fiatqgpllstvadflrmlkelgittivnlt.........eelywpell.....

vtvtlhqseifadyeirtfilskakrsgSRMVRQFHFTVWPDKGVPQyATAVLAFRRKVRAlnprDAGPVIVHCSAGVGRTGAYIVIDAMLEQakksrTV
                             |.. |.... ||| |||     .|.| ..|..    . |||.|||||||||||...... |...      |
............................erlgiqylylpwpDhgvpd.ldelldfieevle....eggpvlVHCsaGvgRtgtlvaaylmkkl.....gv

DIRNYLIALRKDRPHMVQTKEQYSFIHSAVLEALTCGNTE
.... .  .|. ||.||.| .|| |.. |.|| | ...|.
sleeavklvrsrRpgmvitpnqyfflqlallellllkktr
subfamily_PTPN3_pd Subfamily PTPN3 285-532 6.7e-50 164.6 In-house 26-277 (280) alignment 
Range on Protein: 285-532
Range on HMM: 26-277/280.0
REIPAEEKSVGEKPQNLHKNRFSDIIALNSCRVMLHKEhadeESDYINAVFLHVRMER----NAFIATQHPLQHTIEDFWRMVTDYDIGTIVMLNNLHEH
|  |  . |.  ||.||.|||. ||.. .. ||.|...    |.||||| .. . ..     | .|||| ||..| .|||.|| . .. .|||| .| |.
rkkpglaisaarkpenlsknryrdilpydatrvklkes....etdyinanyvnmeipstglvnryiatqGPlaktatdfWqmvweqksslivmlttlver

DQ-EYPQYLPVEG-ATKYGHIRVSLLSKQEKGDVISTKLKVTRNK--KTHEVRHLHHVSWPDKCIPEVARSVLDLLDEVQASQqQCGNAPVLVQCSNGVG
 .    || | ..  ..||...| . ...|.  ..  .| .....  . ... .| ...|||...|. . ..|.....|.. . .  . ||.| || |.|
GrvkChqyWPetedeleygefsvkcekedetksyvlrelvlkdketkeerkilqlqylaWpdhgvPddsadflefvervrklr.sgkeePvvvhCsaGig

RSGTFCAISSVIERLKTEQVIDVFQVIKRIRANRPGAVESLTQYVF-CYQIIQKYLD
|.| . ..   .  . ... . . ......|  |   |.. .|| | |  |.. | .
rtGvlilletalalieaaepvypldivrtmrdqramlvqtasqykfvCeailkvyee
subfamily_PTPN13_pd Subfamily PTPN13 270-532 3.8e-47 155.9 In-house 11-270 (273) alignment 
Range on Protein: 270-532
Range on HMM: 11-270/273.0
TGYALEFQRLNSVTsreiPAEEKSVGEKPQNLHKNRFSDIIALNSCRVMLHKEHAdeesdYINAVFLHVRMERNA--FIATQHPLQHTIEDFWRMVTDYD
   | ||. |. .     | .. .||.| .| .|||. ...  .  || | .| .     |||| ...|... .   .||.| || .|..|||.|| . .
qqPaeefkelrelk....pldtcevgkkkenkdknryrnvlPydetrvklgdegg.....yinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweqk

IGTIVMLNNLHEHDQ-EYPQYLPVEGA---TKYGHIRVSLLSKQEKGDVISTKLKVTR--NKKTHEVRHLHHVSWPDKCIPEVARSVLDLLDEVQASQQq
   |.|. .  |...    .| |..     . .. ..|.||  |.. .    .|.|.    ....|| ||. |.|||  .|  | ..| .. ||.  |. 
aeviamvtlekekgkvkchrywPesknkklkvsnrlevellkvqkldgfvvralavkdsesgesrevahlnfvkwPdhgvPssaaellqfvaevrrlqt.

cGNAPVLVQCSNGVGRSGTFCAISSVIERLKTEQVIDVFQVIKRIRANRPGAVESLTQYVFCYQIIQKYLD
  ..|..| || |.|||||. .|  |.. .. .. .|| ......|  | | | .  ||.|.|..| . | 
.dagPivvhcsaGiGrsGtlitidvvlglierdkefdvkeivrklreqrqgvvqtkdqyifvykailevlk
subfamily_PTPN14_pd Subfamily PTPN14 280-532 1.1e-46 154.2 In-house 30-297 (300) alignment 
Range on Protein: 280-532
Range on HMM: 30-297/300.0
NSVTSREIpAEEKSVGEKPQNLHKNRFSDIIALNSCRVMLHKEHADeESDYINAVFL--HVRMERNAFIATQHPLQHTIEDFWRMVTDYDIGTIVMLNNL
. .. ..    . |... |.| .|||| |..  . .|| |   . . ...||||  .   |  ..  .|..| ||..|..|||.|| . ..  |||| . 
eripkkre.dallstaklpenaeknrfkdvlPyednrvelsptken.stgyinassikvsvggkersyivaqgPleltvqdfWqmvWeqgvqlivmltee

HEHDQEY-PQYLPVE----GATKYGHIRVSLLSKQEKGDVISTKLKVT--RNKKTHEVRHLHHVSWPDKCIPEVARSVLDLLDEVQASQQQC--------
.|. .|   .|.| .       ..|. .|.   ... . || |.||.     |.  .| || .. |||. .||  .. |. |.|||. ...         
eedgkeksfkyfPkleskkktvefgkfkvttkfsedsdsvittglklkhlpskeertvwhlqytDWpdhgvPeDvkgflsyLeevqsvrrktnseveske

GNAPVLVQCSNGVGRSGTFCAISSVIERLKTEQVIDVFQVIKRIRANRPGAVESLTQYVFCYQIIQKYLD
 . |||| ||.||||.|       .|. |.....||. .|..|.|  |   |..|.|| | |... |||.
skPPvlvhCsaGvGrtGvlilsdlliatlehneeidikkvlarLreqrmllvqtlaqYkfvYkvlikylk
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 275-530 1.2e-46 153.9 In-house 11-258 (267) alignment 
Range on Protein: 275-530
Range on HMM: 11-258/267.0
EFQRLNSVTSREIpAEEKSVGEKPQnlHKNRFSDIIALNSCRVMLHKEHADeesdYINAVFLHVRMERNAFIATQHPLQHTIEDFWRMVTDYDIGTIVML
||. .. ... .     .|..|| |   .||. | .  .  ||.| ..  .    |||| ...    .||||.|| ||. || ||. ...|... .||.|
efelikkisdtss.tisqsiaeknq..ernrlddnlpyddtrvilrtkeee....yinasyvegyktknafivtqdplkntitdfltvihdqkvpvivll

NNLHEhdQEYPQYLPVE--GATKYGHIRVSLLSKQEK--GDVISTKLKVtRNKKTHEVRHLHHVSWPdkcIPEVARSVLDLLDE-VQASQQQCGNAPVLV
 .  .  .. ... | .   | ||  . |    ..|.   ..|. .||. .|. .|.|   ..  |    |    .  |  |   .   | . || |..|
tkvft..dnirlfwPPkmgqakkyqdltvehslekeendyqiitlelkf.knesahnvtlyyykkwn...intnnkpylkplfgilaknqlengnrPlvv

QCSNGVGRSGTFCAISSVIERLKTEQVIDVFQVIKRIRANRPGAVESLTQYVFCYQIIQKY
.||.||||||||  | | .||.|||.| |.|. ...||  |.| |... .|....... .|
acsdGvGrsGtflvidsqleraktegvsdifdflrkirsqriglvdtkeryiyihellaey
0036282 (Phosphotyrosine protein) phosphatases II 36-234 1.5e-46 153.6 In-house 2-163 (174) alignment 
Range on Protein: 36-234
Range on HMM: 2-163/174.0
SDYINASFIHGYDGTPrSFIASQGPLPpafegFWRMVWEQNSQSIVMLTNLVELGKTKCHKYWPDktetyggvtvtlhqseifadyeirtfilskAKRSG
|||||||.....  ||  .||.||||.     ||.|..|......|||....|||..||. |||.                               . . 
sdyinaspldlsyitp.rliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe..............................lredl

SRMVRQFHFTVWPDKGVPQYATaVLAFRRKVRALNPR-DAGPVIVHCSAGVGRTGAYIVIDAMLEQAKkSRTVDIRNYLIALRKDRPHMVQTKEQYSFIH
.|.. |.... ||| |||  .. .| | . |.    . . |||.|||||||||||. .... || . . ...||. ... .||. ||.|||| .|| |..
erlgiqylylpwpDhgvpdlsi.llefvkfveealsedpggpvlVHCsaGvgRtGtlvaaylmlrgll.eslvdaldlvrelRlqrpgmvqtpsQyrfly
0051429 (Phosphotyrosine protein) phosphatases II 328-534 2.2e-46 154.0 In-house 4-228 (272) alignment 
Range on Protein: 328-534
Range on HMM: 4-228/272.0
SDYINAVFLHVRME---RNAFIATQHPLQHTIEDFWRMvTDYDIGTIVMLNNLHEHDQEY-PQYLP------------VEGATKYGHIRVSLLSKQEKGD
|.|||| ..        .........||..|..||||.  ...| |||.| ...|....  ..|.|            ..    ||..|| |||.. . |
sgyiNardvggygrvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseellld

VISTKLKVT---RNKKTHEVRHLHHVSWPDKCIPEVArsVLDLLDEVQAsqqqcgNAPVLVQCSNGVGRSGTFCAISSVIERLKTEQVID--------VF
.| ..| .|    .....||.|||. .||| ..|. |  .|.||.....      . |||| || |..|.||..|.  .....  |...|        ..
yilrellltlllsagearevmhlhytdwpdhgvpqea..llellellld......ggpvlvHCsaGkdRTGtvvallllllgvsletivddYlltnlyle

QVIKRIRANRPGAVESLTQYVFCYQIIQKYLDSF
......|| |||||.. .||.|.|......|.|.
eaveelraqrpgavqteeqylflyeallellrsl
subfamily_PTPRN_pd Subfamily PTPRN 288-528 3.3e-46 152.3 In-house 44-289 (297) alignment 
Range on Protein: 288-528
Range on HMM: 44-289/297.0
PAEEKSVGEKPQNLHKNRFSDIIALNSCRVMLHKEHADEESDYINAVFLHVRMERN-AFIATQHPLQHTIEDFWRMVTDYDIGTIVMLNNLHEHDQE-YP
  . |.|.....|..||| ..... .  || |..| ..|.|||||| ..  .  |. |.|||| || .|. |||.|| .  .  ||.| .|.|.. .   
epstkevakaeknvkknrskavlpydhsrvklkeeasaeksdyinasaildhdprapayiatqgplastvadfwqmvweqGvvvivnltrleeegvkqck

QYLPVEGATKYGHIRVSLLSKQEKGD---VISTKLKVTRNKKTHEVRHLHHVSWPDKCIPEVARSVLDLLDEVQASQQQcGNAPVLVQCSNGVGRSGTFC
.| | ||.  |.   | |.|.    |   | |  ||  ....|  |  .|..|||.. .|  |.|.|..   |. | .    .|..| ||.|.||.|...
rywpdeGsevyhiyevhlvsehiwcddylvrsfylknlqtsetrtvtqfhflswpeegvPasaksllefrrkvnksyrG.rscpivvhcsdGaGrtGvyi

AISSVIERL-KTEQVIDVFQVIKRIRANRPGAVESLTQYVFCYQIIQ
.|  |..|| |  . ||.   .. .| .||| |..  |. |... . 
lidlvlnrllkGvkeidiaatlehlrdqrpglvktkdqfefaltava
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 288-527 1.3e-44 147.2 In-house 33-232 (392) alignment 
Range on Protein: 288-527
Range on HMM: 33-232/392.0
PAEEKSVGEKPQNLHKNRFSDIIALNSCRVMLHKEHADEESDYINAVFLHVRMERNAFIATQHPLQHTIEDFWRMVTDYDIGTIVMLNNLHEHDqeypqy
.. ...|..|. ||.|||. .|. ..| ||.|       .|||.|| ...     .|.||.| |   ...|||||| . .. ||.|...|.| |      
diypqtvaqkeinlkknryknilpydsarvkleviddipdsdylnasyipsfdnekayiasqgpnaaslddfwrmvfqenvttiamvtklkegd......

lpvegatkyghirvsllskqekgdvistklkvtRNKKTHEVRHLHHVSWPDKCIPEVARSVLDLLDEVQASQQQCGnAPVLVQCSNGVGRSGTFCAISSV
                                 . .... |   | . |||| .|. . |.| .. ||.|   |    |....|| ||||.|   .| ||
.................................kgddartvaqfhftewPdkdvpkhtssllkfikevkadfGqyt.hpliihcsagvgrtgvvisidsv

IERLKTEQVIDVFQVIKRIRANRPGAVESLTQYVFCYQII
. . |. ...|||...  || .||  |..  || | |  .
vahakktrmvdvfnfvtnirrkrpymvqtkeqyafiygav
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 8-239 1.9e-44 146.5 In-house 56-281 (290) alignment 
Range on Protein: 8-239
Range on HMM: 56-281/290.0
NKNKNRYANIVAYDHSRVVLErvNGdEDSDYINASFIHGydgTPRSFIASQGPLPPAFEGFWRMVWEQNSQSIVMLTNLVELGKTKCHKYWPDKT---ET
. .|||| ..|  | .||.|.  .|  | ||. | ...|   .   || .||.|  .   .|||| ...   |||| .|.| ||.||..|.|.|     |
efkknrykdvvcndktrvilk..dG.ydGdyvhanyvkG...lkamfiltqGalkdtvidiwrmvlqekvaaivmlceliedGkakceqyypekeGevlt

YGGVTVTLHQSEIFADY-EIRTFILSKAKRSGSRMVRQFHFTVWPDKGVPQYATAVLAFRRKVRALnprdAGPVIVHCSAGVGRTGAYIVIDAMLEQAKK
.| .||.  ...   .    .|. . . .   . ... ..   |||| |.. . |.|   | .| .    .|||.||||||.||||... |.. |.   .
fGeitvlcseeddkdaniikktlsvrdkdsGkehklkhlkikswpdksvalstlallrtlrilrka....sGpvvvhcsaGiGrtGtfvaievglqilld

SRTVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVLE
 . .|. .   |||. |   ||   ||  .  ..|.
Gkeldlldlvralrnsrlnsvqvdiqylalveilld
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 293-529 5.6e-44 145.3 In-house 41-277 (439) alignment 
Range on Protein: 293-529
Range on HMM: 41-277/439.0
SVGEKPQNLHKNRFSDIIALNSCRVMLHKEHADEESDYINAVFLHVRMERNAFIATQHPLQHTIEDFWRMVTDYDIGTIVMLNNLHEHDQeypqYLPVEG
|.  .  .  |||. |. |..  ||.|..      | |||| ...   . . .|||| | ..| .||||.| .    ||||| || |  .    | | ..
slaaqeydqtknrykdvgafdhtrvtlqeipgvphshyinanyikGyyddklyiatqgpkkettddfwrlviekktvtivmltnlvesyk....ywpsda

ATKYGHIRVSLLSKQEKGDVISTKLKVTR----NKKTHEVRHLHHVSWPDKCIPEVARSVLDLLDEVQASQQQCGNAPVLVQCSNGVGRSGTFCAISSVI
 . || | |    . |  . .   .||      ..| . | ..|...|||| .|  |  |||.|  .......    ||.|.|| ||||.||  |.   .
evcygdiavrvdrnielpnyvirgfkvfnerdttekertvlqfhyiawpdknvpaqashvldflrainsandkeeygpvvvhcsagvGrtGtiialdial

ERLKTEQVIDVFQVIKRIRANRPGAVESLTQYVFCYQIIQK
|.||.|. .|.  ..| .| .|   |..| |||| |. . .
eqlklenkvdikgivkvlrkqrkqmvqalcqyvfiynavle
subfamily_PTPN1_pd Subfamily PTPN1 290-527 1e-43 144.1 In-house 22-267 (290) alignment 
Range on Protein: 290-527
Range on HMM: 22-267/290.0
EEKSVGEKPQNLHKNRFSDIIALNSCRVMLHKEHAdeesDYINAVFLHVRMERNAFIATQHPLQHTIEDFWRMVTDYDIGTIVMLNNLHEHDQE-YPQYL
 . .. ..|.|  .||. |.   . .|..|....     ||||| ....   .  .| || || .|.. ||.|| . .  ..||||.. |..|    || 
fptreaklpenrnlnryrdvspydhsrikleradn....dyinaslveleeakrsyiltqGPlpntvdhfWqmvWeqkskavvmlnkvvekeqikcaqyw

PVEGA---TKYG--HIRVSLLSKQEKGDVISTKLKVTR--NKKTHEVRHLHHVSWPDKCIPEVARSVLDLLDEVQASQQQC-GNAPVLVQCSNGVGRSGT
| .      ..   ...| |.|...|   .  .|...    ..|.|. | |...|||  .||   . |..| .|. |        |... || |.|||||
PqgeeekellledtklkvkliseerksyytvrllelenlktqetreilhfhyttwpdfgvpespaaflkflfkvresGslssdvGpavihcsaGiGrsGt

FCAISSVIERLKTE---QVIDVFQVIKRIRANRPGAVESLTQYVFCYQII
|| . ... ... .   . .|. .|.  .|  | | .    |  | |. |
fclvdtclvliekkddlssvdikkvllelrkyrlGliqtadqlrfsylai
0049772 (Phosphotyrosine protein) phosphatases II 260-534 1.6e-43 145.0 In-house 6-283 (314) alignment 
Range on Protein: 260-534
Range on HMM: 6-283/314.0
LASVNRKFQMTGYALEFQRLNSVTSREIPAEEKSVGEKPQNLHKNRFSDIIALNsCRVMLHKEHADEeSDYINAVFLHVRmerNAFIATQHPLQHTIEDF
|||...  ..  .  ....||... . .|.    |. .. | .|||. ||.  . .||.|.... .  |||||| ...     ..|||||.||..|..||
lasfsellihddllklllvlnrrslsvlpeltilvadlflnrdknryldilpad.nrvilpglpvsg.sdyinasyvdgf...lkfIatqgpleitvvdf

----------WRMV--TDYDIGTIVM---------------------LNNLHEHDqeypqylPVEGATKYGHIRvsllskqekgdvistklKVT--RNKK
          ||||   |... .|||                     |..| ..        .   |  . ...                 ...  ... 
reepvlyyngwrmvlrgdlnvrdivmsrdevladelsrLdaAlgKtpllildgng.......neptaadlellk.................eelydpelf

THEVRHLHHVSWPDKCIPeVARSVLDLLDEVQASqqqCGNAPVLVQCSNGVGRSGTFCAISSVIERLKteqViDVFQVIKRIRANRP-----GAVESLTQ
.... ..... .|| . |   . ....|. ...      . |||| |. |.||.|||...  .. .|.   | .. ......|. ||     |..|.| |
erlgikylripvpDgsap.lledfdeflefieea...dkggpvlvHCkaGkgRtgtfvvaaylmkllg...v.sleealedvrlkRpinpnpgfieqleq

YVFCYQIIQKYLDSF
|.|.......||. .
yefilealleylkfl
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 7-241 2.5e-43 143.2 In-house 40-277 (307) alignment 
Range on Protein: 7-241
Range on HMM: 40-277/307.0
ANKNKNRYANIVAYDHSRVVLErVNGdEDSDYINASFIhGYDGTPRSFIASQGPLPPAFEGFWRMVWEQNSQSIVMLTNLVELGKTKCHKYWPD---KTE
|| .|||| .. . |..|.|.. ..|   |||| | .. |    |. ||..||||  .   || |. ... .|..|| ...||.| ||..|||    .. 
antdknryqdvkcqdkgrivvk.fdg.lasdyihanyl.giaikpkkficaqgplentqysfwamaiqekvesvimlckvielakikceqywpleegqkl

TYGGVTVTLHQ-----SEIFADYE-IRTFILSKAKRSGSRMVRQFHFTVWPDKGVPQYATAVLAFrrkVRALNpRDAGPVIVHCSAGVGRTGAYIVIDAM
..|  . |.        ..  | . |    |     ..|| .... .. |||.||||   . . .   . | .  |  ||.|||||||||.|. . |  .
vfgeapntisvanlgakklapdedlinvttlkvdwaqksrtiqhlqwenwpdrgvpqinltainl...leavr.ydtnpvvvhcsaGvGrsGtivaislv

LEQAKKS-RTVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVLEAL
 ..  .     |... .  ||..|.. .||. || ..|  .|| .
qdkmiaGinckdmkklveelrsqrhyaiqteaqylylhrvlleyf
0046846 (Phosphotyrosine protein) phosphatases II 30-239 8.4e-43 141.5 In-house 6-171 (176) alignment 
Range on Protein: 30-239
Range on HMM: 6-171/176.0
VNGDEDSDYINASFIHGYDgtprsFIASQGPLPPAFEGFWRMVWEQNSQSIVMLTNLVELGKTKCHKYWPDKTETYGgvtvtlhqseifadyeirtfils
   |.|.|||||..| |.      .|| |||||  .. |..|..|.. . .|.||..||||. ||. |||. ..                          
lgldldldyinanlilgsr.....piatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgi.......................

kakrsgsrmvrQFHFTVWPDKGVPQYaTAVLAFRRKVRALNPRDaGPVIVHCSAGVGRTGAYIVIDAMLEqakkSRTVDIRNYLIALRKDRP-HMVQTKE
           |.... ||| |||.. ...| . . .|    .. |||.||||||.||||...... .      .. ... . |  .|. || ..||| |
...........qylhlpwpDhgvpdl.elllellefirealkeg.gpvlVHCsaGigRtgtlvaayllel....ekglsveealalvreqRplgavqtpe

QYSFIHSAVLE
|| |.. ..|.
Qyrflyefell
0041856 (Phosphotyrosine protein) phosphatases II 300-529 2.7e-42 139.8 In-house 1-169 (182) alignment 
Range on Protein: 300-529
Range on HMM: 1-169/182.0
NLHKNRFSDIIALNSCRvmlhkehadeESDYINAVFLHVRMERNAFIATQHPLQHTIEDFWRMVTDYDIGTIVMLNnlhehdqeYPQYLPvegatkyghi
||.|||.|||.  .  |           .||||| ..   .  . |||||.||..|..||.||. ...|.|||.|.         ..| |          
nldknrysdilpydhsr..........dldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt........eelywp..........

rvsllskqekgdvistklkvtrNKKTHEVRHLHHVSWPDKCIPEvARSVLDLLDEVQAsqqqcGNAPVLVQCSNGVGRSGTFCAISSVIERlkteQvIDV
                      .. .... ......||| ..|.  ...||...||..      . |||| || ||||.||..|.  ....    . ...
......................ellerlgiqylylpwpDhgvpd.ldelldfieevle.....eggpvlVHCsaGvgRtgtlvaaylmkkl....g.vsl

FQVIKRIRANRPGAVESLTQYVFCYQIIQK
....| .|  |||.|... ||.|.....  
eeavklvrsrRpgmvitpnqyfflqlalle
0049772 (Phosphotyrosine protein) phosphatases II 3-243 3.8e-42 140.5 In-house 41-282 (314) alignment 
Range on Protein: 3-243
Range on HMM: 41-282/314.0
ARKPANKNKNRYANIVAYDhSRVVLERVNGDeDSDYINASFIHGYdgtpRSFIASQGPLPPAFEGF----------WRMV--WEQNSQSIVM--------
|....|..|||| .|. .| .||.| ..... .|||||||...|.    ..|||.||||.  .. |          ||||  ...|.  |||        
adlflnrdknryldilpad.nrvilpglpvs.gsdyinasyvdgf....lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivmsrdevlad

-------------LTNLVELGKTKCHKYWPDKTetyggvtvtlhqseifadyE-------IrtfilskakrsgSRMVRQFHFTVWPDKGVPqYATAVLAF
             |..| ..|   . .....                     |                    .|.. ... . .|| ..|     ...|
elsrLdaAlgKtpllildgngneptaadlellk...................eelydpelf............erlgikylripvpDgsap.lledfdef

RRKVRALnpRDAGPVIVHCSAGVGRTGAYIVIDAMLEQAKksrtVDIRNYLIALRKDRP-----HMVQTKEQYSFIHSAVLEALTC
 . ....  .. |||.|||.||.|||| ..|.. .. . .    |...  |  .|. ||     ..... ||| ||. |.||.|  
lefieea..dkggpvlvHCkaGkgRtgtfvvaaylmkllg....vsleealedvrlkRpinpnpgfieqleqyefilealleylkf
0036282 (Phosphotyrosine protein) phosphatases II 328-525 5.4e-42 138.8 In-house 2-164 (174) alignment 
Range on Protein: 328-525
Range on HMM: 2-164/174.0
SDYINAVFLHVRMERNAFIATQHPLQhtiedFWRMVTDYDIGTIVMLNNLHEHD-QEYPQYLPVegatkyghirvsllskqekgdvistklkvTRNKKTH
|||||| .|.. .  . .||.|.||.     ||.|. ...| |.|||....| .    ..| |                              .|.  ..
sdyinaspldlsyitprliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe.............................lredler

EVRHLHHVSWPDKCIPEVARsVLDLLDEVQASQQQCGNAPVLVQCSNGVGRSGTFCAISSVIERLKtEQVIDVFQVIKRIRANRPGAVESLTQYVFCYQ
.. ..... ||| . |...  .|.....|.  ...... |||| || ||||.||..|.  .. .|. | ..|........|  |||.|..  || |.|.
lgiqylylpwpDhgvpdlsi.llefvkfveealsedpggpvlVHCsaGvgRtGtlvaaylmlrgll.eslvdaldlvrelRlqrpgmvqtpsQyrflyy
0043147 (Phosphotyrosine protein) phosphatases II 32-234 3.8e-41 136.0 In-house 1-154 (172) alignment 
Range on Protein: 32-234
Range on HMM: 1-154/172.0
GDEDSDYINASFIHGYDGTPRsFIASQGPLPPAFEGFWRMVWEQNSQSIVMLTNLvelgktkchkywpdktetyggvtvtlhqseifadyeirtfilSKA
|||.|||||||....|  ..| ||| ||||.  .. ||||..|.. . ||.||.|                                           . 
gdegsdyinasyldlyyipdr.fiatqgplrntladfwrmlkelgithivnltel..........................................lyd

KRSGSRMVRQFHFTVWPDKGVPqYATAVLAFRRKVRA-LNPRDAGPVIVHCSAGVGRTGAYIVIDAMLeqakksRTVDIRNYLIALRKDRPHMVQTKEQY
.   .|.. |.... ||| |||  .  .| | . ..  |. .. |||.|||||||||||. .... ||      . ... . .  .|. ||..||...||
pellerlgiqylylpwpDhgvp.llellleflefidellalspggpvlVHCsaGvgRtgtlvaaylml......lglsleeavalvrekRpgavqnpsqy

SFIH
 |..
rfly
0043147 (Phosphotyrosine protein) phosphatases II 325-525 5.3e-41 135.5 In-house 2-155 (172) alignment 
Range on Protein: 325-525
Range on HMM: 2-155/172.0
DEESDYINAVFLHVRMERNAFIATQHPLQHTIEDFWRMVTDYDIGTIVMLNNLhehdqeypqylpvegatkyghirvsllskqekgdvistklKVTRNKK
|| |||||| .|..    . ||||| ||..|..|||||. ...|..||.|..|                                         ... . 
degsdyinasyldlyyipdrfiatqgplrntladfwrmlkelgithivnltel........................................lydpell

THEVRHLHHVSWPDKCIPeVARSVLDLLDEVQASQQQCGNAPVLVQCSNGVGRSGTFCAISSVIerlkteQVIDVFQVIKRIRANRPGAVESLTQYVFCY
.... ......||| . |  .. .|..|. ..  .... . |||| || ||||.||..|.  ..      . ........ .|. |||||..  || |.|
erlgiqylylpwpDhgvp.llellleflefidellalspggpvlVHCsaGvgRtgtlvaaylml......lglsleeavalvrekRpgavqnpsqyrfly

Q
.
y
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 254-532 2.6e-40 132.9 In-house 11-284 (290) alignment 
Range on Protein: 254-532
Range on HMM: 11-284/290.0
NQAMQKLASVNRKFQMTGYALEFqrLNSVTSR-EIPAEEKSVGEKPQNLHKNRFSDIIALNSCRVMLHKehaDEESDYINAVFlhVRMERNAFIATQHPL
 .|..|.||   | .. ..| |.  |. .         |... .|  ...|||. |..  .  ||.|.      . ||. | .  |.  .  || || .|
teafekfasdvvkknvdelakey..leklkpylpvqylerkifdkntefkknrykdvvcndktrvilkd...GydGdyvhany..vkGlkamfiltqGal

QHTIEDFWRMVTDYDIGTIVMLNNLHEHDQE-YPQYLPV-EG-ATKYGHIRVSLLSKQEKGDVISTK-LKVT--RNKKTHEVRHLHHVSWPDKCIPEVAR
. |. |.|||| . .. .|||| .| |. .    || |  || .  .|.| |    ...| . |  | | |    . | | ..||. .|||||...  . 
kdtvidiwrmvlqekvaaivmlceliedGkakceqyypekeGevltfGeitvlcseeddkdaniikktlsvrdkdsGkehklkhlkikswpdksvalstl

SVLDLLDEVQasqQQCGnaPVLVQCSNGVGRSGTFCAISSVIERLKTEQVIDVFQVIKRIRANRPGAVESLTQYVFCYQIIQKYLD
..| .|  ..   .  |  || | || |.||.||| ||   .. |   . .|. .... .|  | ..|.  .||.   .|. ..  
allrtlrilr...kasG..pvvvhcsaGiGrtGtfvaievglqilldGkeldlldlvralrnsrlnsvqvdiqylalveilldlGk
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 297-524 5.1e-40 132.1 In-house 5-234 (239) alignment 
Range on Protein: 297-524
Range on HMM: 5-234/239.0
KPQNLHKNRFSDIIALNSCRVMLHKEHADEESDYINAVFLHV-RMERNAFIATQHPLQHTIEDFWRMVTDYDIGTIVMLNNLHE-HDQEYPQYLPvEGAT
|  |  |||...|.. .  ||.| |   |  |||||| .|.      .|.||||  .. .  |||||. .     ||||  | | | ..  || | . ..
krvnkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywp.dsts

KYGHIRVSLLSKQEKGDVISTKLKVTRNKKTHE--VRHLHHVSWPDKCIPEVARSVLDLLDEVQAsQQQCGNAPVLVQCSNGVGRSGTFCAISSVIERLK
||  .||.|   .   | |   . ...  .| |  | . |   |||| .|. | .|| |  ..   .   |  | ...|| ||||.|.|  | ... . |
kycnlrvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrkitk.dslpgarpwvihcsagvgrtgaflvidamlrqak

TEQVIDVFQVIKRIRANRPGAVESLTQYVFCY
 .. .|.|. .| || .||  |..  |||| .
kqktvdifnyvkairedrphmvqtseqyvfih
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 297-524 5.5e-40 132.0 In-house 4-233 (239) alignment 
Range on Protein: 297-524
Range on HMM: 4-233/239.0
KPQNLHKNRFSDIIALNSCRVMLHKEHADEESDYINAVFLHV-RMERNAFIATQHPLQHTIEDFWRMVTDYDIGTIVMLNNLHE-HDQEYPQYLPvEGAT
|  |  |||...|.. .  ||.| |   |  |||||| .|.      .|.||||  .. .  |||||. .     ||||  | | | ..  || | . ..
krvnkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywp.dsts

KYGHIRVSLLSKQEKGDVISTKLKVTRNKKTHE--VRHLHHVSWPDKCIPEVARSVLDLLDEVQAsQQQCGNAPVLVQCSNGVGRSGTFCAISSVIERLK
||  .||.|   .   | |   . ...  .| |  | . |   |||| .|. | .|| |  ..   .   |  | ...|| ||||.|.|  | ... . |
kycnlrvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrkitk.dslpgarpwvihcsagvgrtgaflvidamlrqak

TEQVIDVFQVIKRIRANRPGAVESLTQYVFCY
 .. .|.|. .| || .||  |..  |||| .
kqktvdifnyvkairedrphmvqtseqyvfih
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 8-239 6.4e-40 131.8 In-house 33-257 (267) alignment 
Range on Protein: 8-239
Range on HMM: 33-257/267.0
NKNKNRYANIVAYDHSRVVLERVNGDedsdYINASFIHGYDgTPRSFIASQGPLPPAFEGFWRMVWEQNSQSIVMLTNlveLGKTKCHKYWPDK---TET
|...||. . . ||..||.|   . .    |||||...||  | . ||. |.||  .   |. .. .|.   ||.||.    .. . ...|| |   .. 
nqernrlddnlpyddtrvilrtkeee....yinasyvegyk.tknafivtqdplkntitdfltvihdqkvpvivlltk...vftdnirlfwPPkmgqakk

YGGVTVTLHQSEIFADYEIRTFILsKAKRSGSRMVRQFHFTVWPDKG-VPQYATAVLAFRRKVRALNprDAGPVIVHCSAGVGRTGAYIVIDAMLEQAKK
|  .||     .   ||.| |. | | |   .. |  ...  |  .     |   ...   | .  |     |..|.||.||||.|...|||..||.||.
yqdltvehslekeendyqiitlel.kfknesahnvtlyyykkwnintnnkpylkplfgilaknqlen..gnrPlvvacsdGvGrsGtflvidsqlerakt

SRTVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVLE
  ..|| ..|  .|. |. .|.|||.| .||  . |
egvsdifdflrkirsqriglvdtkeryiyihellae
0049260 (Phosphotyrosine protein) phosphatases II 51-234 1.2e-39 130.7 In-house 8-143 (152) alignment 
Range on Protein: 51-234
Range on HMM: 8-143/152.0
PRSFIASQGPLPPAFEGFWRMVWEQNSQSIVMLTNLVELGKTKCHKYWpdktetyggvtvtlhqseifadyeirtfilskakrsgsrmvrQFHFTVWPDK
|. ||| |||.|  .. ||||..|.. . |||||.|.|||| ||..|.                                          |.... ||| 
pfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi..........................................qylhlpwpDh

GVPQYATAVLAFRRKVRALNPRDAGPVIVHCSAGVGRTGAYIVIDAMLeqakksRTVDIRNYLIALRKDRPHMVQTKEQYSFIH
|||. .  .| . . .. |. .. |||.|||||||||||...... ||      . |.. ...  .|. ||..|....|. |..
gvpdlsqlllflllfieklaldkggpvlVHCsaGvgRtgtlvaaylml......lgvsleeavalvrekRpgavpnpgqlrfly
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 8-239 2.5e-39 129.7 In-house 55-287 (305) alignment 
Range on Protein: 8-239
Range on HMM: 55-287/305.0
NKNKNRYANIVAYDHSRVVLERVNgdeDSDYINASFIHGYDGTPRSFIASQGPLPPAFEGFWRMVWEQNSQSIVMLTNLVELGKTKCHKYWP----DKTE
.. ||||... . |.| | |.. .    |||| | ..       . ||..||||  . . || || ... . |||| . ||||| || .|||    .| |
aitknryqdvpcqdqsavkldkps...psdyihanyvgcpmipekrficaqgpldqtidefwwmviqnkveqivmlcktvelgklkcaqywpaaqgekle

TYGGVTVTLH--QSEIFADYEIRTFILSKAKRSGSRM-VRQFHFTVWPDKGVPQYATAVLAFRRKVRAlnprDAGPVIVHCSAGVGRTGAYIVIDAMLEQ
  .|. |        .  | ||.  .|  .   . .| ||....| |||.|||    . | .   .|        |..||||||.||||. . |. .||.
lksgivvenvsgskpmerdaeiqitllnltysgdqkmsvrhlqwtewpdrgvppckltslellsairg....skvpivvhcsagigrtgtivaieyilek

AKKSR-TVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVLE
  . .    . . . ||| .| . .|.  || |||  .|.
iaenkpcppmpelvkalrdqrafsiqndvqylfihrvmln
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 299-527 7.4e-39 128.4 In-house 2-235 (237) alignment 
Range on Protein: 299-527
Range on HMM: 2-235/237.0
QNLHKNRFSDIIALNSCRVMLHKEHADeeSDYINAVFLHV-RMERNAFIATQHPLQHTIEDFWRMVTDYDIGTIVMLNNLHEHDQE-YPQYLPV-EGATK
.|  |||...|.| . .||.|.   ..  |||||| .|.      . .||.| ||. . .|||.|| .     ||||  | | ...   .| |  .  . 
enkiknrygnivaydhsrvvlkgagsg..sdyinatylkgfdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywpstdqpaa

YGHIRVSLLSKQEKGDVISTKLKVTRNKKTHEVRHLH---HVSWPDKCIPEVARSVLDLLDEVQ-ASQQQCGNAPVLVQCSNGVGRSGTFCAISSVIERL
|| . |||  |.|  |     | .... . .||| .|     ||||. .|. . ..| .  ..   |.     .| .. || ||||.| |  | ... . 
ygvltvslkkkeefsdytvrslllskrltlkevrlihqyqftswpdrgvpqqtaallrfrkniinrsphvsesgpwiihcsagvgrtgiflvidamlrqa

KTEQVIDVFQVIKRIRANRPGAVESLTQYVFCYQII
| ..|.|... .. |  .||  ...  |||| .| |
kekkvvdiynyvysieedrpyiiqtkdqyvfihqti
0046846 (Phosphotyrosine protein) phosphatases II 321-532 8.5e-39 128.4 In-house 5-174 (176) alignment 
Range on Protein: 321-532
Range on HMM: 5-174/176.0
KEHADEESDYINAVFLHVRMernaFIATQHPLQHTIEDFWRMVTDYDIGTIVMLNNLHEHDQEY-PQYLPVegATKYGHirvsllskqekgdvistklkv
. . |. .||||| ..   .    .||||.|| .|..||..|. ...|...|.|....|...   |.| |.   .|.|.                     
llgldldldyinanlilgsr....piatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpe..leklgi.....................

trnkkthevrHLHHVSWPDKCIPEVaRSVLDLLDEVQASQQQcgNAPVLVQCSNGVGRSGTFCAISsvieRLKTEQVIDVFQVIKRIRANRP-GAVESLT
          . .|. ||| ..|.  . .|.||....  ...  . |||| || |.||.||..|.      |..|. ..|.......|. || |||..  
..........qylhlpwpDhgvpdl.elllellefirealke..ggpvlVHCsaGigRtgtlvaay....llelekglsveealalvreqRplgavqtpe

QYVFCYQIIQKYLD
|| |.|. ....|.
Qyrflyefellllk
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 5-240 3.3e-38 126.2 In-house 45-286 (305) alignment 
Range on Protein: 5-240
Range on HMM: 45-286/305.0
KPANKNKNRYANIVAYDHSRVVLervNGDEDSDYINASFIHGyDGTPRSFIASQGPLPPAFEGFWRMVWEQNSQSIVMLTNLVELGKTKCHKYWPDKTE-
.  ...|||| ..   |. || |   .|    .|| | ..      |. || .| ||  .   || | .... ..| || ||.| |  ||..|.. | . 
eaqeagknrykdvgcldnnrvkl...egpwpheyihanyvst.ptnpkrfictqaplektcadfwymclqdkveaifmlcnllekgakkcleyfaskdkd

------TYGGVTVTLHQSEIF-----ADYEI-RTFILSKAKRSGSRMVRQFHFTVWPDKGVPQYATAVLAFRRKVRALNprdaGPVIVHCSAGVGRTGAY
          ..| .  |. .     |. .. .| .. .   . .| | ..|.  |||.|||   .|.| .  | |..     ||..||||||.||||. 
vlefeekgqkisvkfessvtlkfrkdakakvtetvlviegpgekarkvthyhwidwpdrgvpaadlailellekarpsk....gpivvhcsagigrtgsv

IVIDAMLEQAKKSRTVDIRN-YLIALRKDRPHMVQTKEQYSFIHSAVLEA
.... .|.|    . ..  .  |  .|..|   .|| .|| |.|  .|. 
vmleyildqllagqiiedtdkilqkireqrnnsiqtdaqylfvhqvilny
0044763 (Phosphotyrosine protein) phosphatases II 20-238 3.6e-38 126.3 In-house 2-168 (178) alignment 
Range on Protein: 20-238
Range on HMM: 2-168/178.0
YDHSRVVLERVNGDEDSDYINASFIHGYdgtprSFIASQGPlppafEGFWRMVWEQNSQSIVMLTNLVELGKTKCHKYWPDKTEtyggvtvtlhqseifa
.|..||.|. . | | |||||||.| ..      ...|..|     . ......|.. ..||.||. .|||. ||..|||....                
ldrtrvllsnleglersdyinaseilpg.....lylgslpp.....addlellkelgithivnlteelelgflkcdpywpeeag................

dyeirtfilskakrsgsrmvRQFHFTVWPDKGVPQYATAVLAFRRKVRALNPRDAGPVIVHCSAGVGRTGAYIVIDAMLEQakksrTVDIRNYLIALRKD
                     |.... .|| |||.    .|.| . .... ... |||.|||||||||.|. .... |...      ... . .  .|. 
....................iqylhipipDhgvpdllehflefvefieealdekggpvlVHCsaGvgRsgtlvaaylmkkl.....glsleeaielvrer

RPhMVQTKEQYSFIHSAVL
|| .|.. .|. ...   |
Rp.ivpnpgqlrqLyefel
subfamily_CG42327_pd Subfamily CG42327 6-167 1.8e-37 123.7 In-house 26-191 (319) alignment 
Range on Protein: 6-167
Range on HMM: 26-191/319.0
PANKNKNRYANIVAYDHSRVVLERVNGDEDSDYINASFIHGYDGTPRSFIASQGPLPPAFEGFWRMVWEQNSQSIVMLTNLVELGKTKCHKYWPD-----
.. |.|.|..|.|   ..||||.|.  |. . |..||.. ||| .| |.||.| .|  .   |||.||||.|. || ||.| |||  .| .|.|      
vtskdksrvinvvPlPetrvvlqrigdddkdeyldasyvrGyddapnsyiaaqvsledsssdfwrtvweqqsrvivqltdlselGikvcaeylPtketld

KTETYGGVTVTLHQSEIFADYEIRTFILSKAKRSGSRMVRQFHFtVWPDKGVPQYATAVLAFRRKVR
 |..|| . ||| . |.   | | |..| . ... || .  . .  |.. .||   .|..|   .||
ntslyGdilvtlkgrevkdryaistlllkrvdkeesrelthywy.kwleaevPaeeaaliamllevr
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 297-531 5.2e-37 122.5 In-house 38-277 (307) alignment 
Range on Protein: 297-531
Range on HMM: 38-277/307.0
KPQNLHKNRFSDIIALNSCRVMLHKEHAdeESDYINAVFLHVRMERNAFIATQHPLQHTIEDFWRMVTDYDIGTIVMLNNLHEHDQ-EYPQYLPVEGATK
   | .|||..|. . . .|.... . .   |||| | .| . .. . ||..| ||. |. .|| |. . .. ...|| .. |  .    || |.|   |
fsantdknryqdvkcqdkgrivvkfdgl..asdyihanylgiaikpkkficaqgplentqysfwamaiqekvesvimlckvielakikceqywpleegqk

--YG----HIRVSLLSKQE---KGDVI-STKLKVTRNKKTHEVRHLHHVSWPDKCIPEVARSVLDLLDEVQASQqqcgnAPVLVQCSNGVGRSGTFCAIS
  .|     | |. |  ..     |.|  |.|||   .|.  ..||    |||. .|..  . ..||. |.  .      ||.| || |||||||  |||
lvfgeapntisvanlgakklapdedlinvttlkvdwaqksrtiqhlqwenwpdrgvpqinltainlleavrydt.....npvvvhcsaGvGrsGtivais

SVIERL-KTEQVIDVFQVIKRIRANRPGAVESLTQYVFCYQIIQKYL
 | ... . .   |. .... .|..|. |...  ||.. .... .|.
lvqdkmiaGinckdmkklveelrsqrhyaiqteaqylylhrvlleyf
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 285-532 6.1e-37 122.0 In-house 24-278 (287) alignment 
Range on Protein: 285-532
Range on HMM: 24-278/287.0
REIPAEEKSVgEKPQNLHKNRFSDIIALNSCRVMLHKEhADEESDYINAVFLHVRMERNAFIATQHPLQHTIEDFWRMVTDYDIGTIVML-NNLHEHDQE
.  .|  |.  |.  . .|||..|.. ..  ||.| .| ..  |||||| ..    . .||||.| |.  |. ||||.| .    .....  .. |  ..
esstatfkaa.eelaavkknryadvlPiddtrvllsae.gelGsdyinanyvasytddeafiaaqgPiaatvrdfwravletrsasvitmtreveearlk

YPQYLPV-EGATKYGHIRVSLLSKQEKGDVIST-KLKVTR--NKKTHEVRHLHHVSWPDKCIPEV----ARSVLDLLDEVQASQQQCGNAPVLVQCSNGV
  .| |  |   . |   | ||... |    ..  |..     .... |. |. .||||| ..      .| |||  . ......  .  |..| .. |.
cykywPerevPmrvGGysvvlldydikePeygvralrlidletrearvvkqldllswPdkvlaPtavglirfvldvkqhielardasevGPlvvhddvGi

GRSGTFCAISSVIERLKTEQVIDVFQVIKRIRANRPGAVESLTQYVFCYQIIQKYLD
||||.. |.  ...||.    .|| .|. |.|  | . | .  |. . |. .  |  
GrsGillatlvlvsrledlGrvdvaavvirlreyraalvqavvqlrllyealvtyyk
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 294-531 1.9e-36 120.6 In-house 37-271 (288) alignment 
Range on Protein: 294-531
Range on HMM: 37-271/288.0
VGEKPQNLHKNRFSDIIALNSCRVMLHkehaDEESDYINAVFLHVRMERNAFIATQHPLQHTIEDFWRMVTDYDIGTIVMLNNLHEHDQE-YPQYLPVEG
. .  .|  ..|. ..   . .|| |.    |.   ||.|  .     .. .| .| ||. ||| .|.|. . |.  ||||..| |. .|   .|.|.. 
idsfianptrdryenlprcditrvkls....ddpdfyiaanvvssakykrrlicaqaPlngtieelWkmllesdveyivmlcellekGkeksaeyfPskl

ATKYGHIRVSLLSKQEKGDV----ISTKLKVTRNKKTHE-VRHLHHVSWPDKCIPEVARSVLDLLDEVqasqqQCGNAPVLVQCSNGVGRSGTFCAISSV
  |    |.    |... |.      . |..... ...  |..||   |.|...||   | | ||. .     .  . |..|..|.||||.||.  |  .
GekarigrlctvvkkkradidklvkvsllriskegeekvivkilhlleWdddgvPenylsplrllevl.....kslqkPivvhssaGvGrtgtlililia

IERLKTEQVIDVFQVIKRIRANRPGAVESLTQYVFCYQIIQKYL
.| |. .  . . ..... |..|  |...  ||.. .... ..|
leslrlddflgirsllaklreerfkaiqtemqylyvhrcvleel
subfamily_ptpA1_pd Subfamily ptpA1 5-199 7.5e-36 118.7 In-house 44-254 (418) alignment 
Range on Protein: 5-199
Range on HMM: 44-254/418.0
KPANKNKNRYANIVAYDHSRVVLERVNGDEDSDYINASFIHGydGTPRSFIASQGPLPPAFEGFWRMVWEQNSQSIVMLTNLVELGKTKCHKYWPDKT--
|  | .||||.||.  .|.|| |....  | |||||| .| |    |. ||..||||| .   |||||||.  . ||||.   |  . || .|||..   
kkhntsknrytnilpvnhtrvqlkkiqdkegsdyinanyidg..aypkqfictqgplpntiadfwrmvwenrcriivmlsresencrikcdrywpeqigg

----------ETYGGVTVTLhqSEIFAD--YEIRTFILSKAKRSGSRMVRQFHFTVWPDKGVPQYATAVLAF-----RRKVRALNPRD-AGPVIVHCSAG
          | .|  .| |   |.  |   || |  .  .    .| . |...  |||. .|...  .  .      |. . .   |   |.|||||||
eqfsiygngnevfgtysvel..veviqdpereiitrnirltfegetrditqyqyegwpdhnipdhtqpfrqllhsitnrqnqiipssdrnvpiivhcsag

VGRTGAYIVIDAMLE
|||||..     |..
vgrtgtfctavimmk
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 8-251 1.2e-35 118.0 In-house 43-281 (288) alignment 
Range on Protein: 8-251
Range on HMM: 43-281/288.0
NKNKNRYANIVAYDHSRVVLErvngdEDSDYINASFIHGYDGTPRSFIASQGPLPPAFEGFWRMVWEQNSQSIVMLTNLVELGKTKCHKYWPDKTE---T
|  ..|| |.   | .|| |.     .|.|.  |. .      .| .| .| ||  . | .|.|. |.. . ||||..|.|.|| |  .|.| |      
nptrdryenlprcditrvkls.....ddpdfyiaanvvssakykrrlicaqaPlngtieelWkmllesdveyivmlcellekGkeksaeyfPsklGekar

YGGVTVTLHQSEIFADYEIRTFILSKAKRSGSRM-VRQFHFTVWPDKGVPQYATAVLAFRRKVRALNprdaGPVIVHCSAGVGRTGAYIVIDAMLEQAKK
.| .     ..    |  ..  .|   |    .. |.. |.  |.|.|||.   . | .   ...|.     |..||.||||||||. |.|  .||... 
igrlctvvkkkradidklvkvsllriskegeekvivkilhlleWdddgvPenylsplrllevlkslq....kPivvhssaGvGrtgtlililialeslrl

SRTVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVLEALTCGNTEIQSE
.  . ||. |  ||..| . .||. || ..|  ||| |     . . |
ddflgirsllaklreerfkaiqtemqylyvhrcvleelllkkykvlre
subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 4-239 1.6e-35 117.1 In-house 33-267 (281) alignment 
Range on Protein: 4-239
Range on HMM: 33-267/281.0
RKPANKNKNRYANIVAYDHSRVVLER-VNGDEDSDYINASFIHGyDGTPRSFIASQGPLPPAFEGFWRMVWEQNSQSIVMLTNLVELGKTKCHKYWPDKT
 .| |..||||.|| . | ||| |.  .   . .||| | .|.      | .| .|||   .   ||||.|..|. .|||| ...|  . || .|.| ..
nqpvnnkknrylnipcldisrvqlkvkmpnknstdyihanyirs.pflkrgyiltqgpkketradfwrmiwqenttaivmlcqfletnrekcaeyfprna

ET---YGGVTVTLHQSEIfaDYEIRTFILSKAKRSGSRMVRQFHFTVWPDKGVPQYATAVLAFRRKVRAlnpRDAgPVIVHCSAGVGRTGAYIVIDAMLE
     .  ..|.  .| .  .  . |  |  .    .|.. .. .  |||  ||. .  .|   ||.||   | . | ..||||||||.|. . ..  |.
hcclqfdklsvsyedstv..nkslvttrlnlsyegetrlithwlwkewpdwqvpessevmlkilrkira...rst.ppvihcsagvgrsgtlmaveialq

QAKKSRTV-DIRNYLIALRK-DRPHMVQTKEQYSFIHSAVLE
  .   |. ||.. .  ||   |   ||| .|| .|   .|.
sihshftlpdikqivshlrvtgraasvqtlqqymliwkvlld
0049260 (Phosphotyrosine protein) phosphatases II 341-525 1.9e-35 117.1 In-house 7-144 (152) alignment 
Range on Protein: 341-525
Range on HMM: 7-144/152.0
ERNAFIATQHPLQHTIEDFWRMVTDYDIGTIVMLNNLHEHDQEYPQYLPvegatkyghirvsllskqekgdvistklkvtrnkkthevrHLHHVSWPDKC
  ..|||||.|. .|..|||||. ...|.|||||..|.| . ..  ...                                        . .|. ||| .
mpfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi........................................qylhlpwpDhg

IPEVARSVLDLLDEVQASqQQCGNAPVLVQCSNGVGRSGTFCAISSVIerlkteQVIDVFQVIKRIRANRPGAVESLTQYVFCYQ
 |. .  .|.||. ..   ..  . |||| || ||||.||..|.  ..      . ..........|. |||||..  |. |.|.
vpdlsqlllflllfiekl.aldkggpvlVHCsaGvgRtgtlvaaylml......lgvsleeavalvrekRpgavpnpgqlrflye
0051082 (Phosphotyrosine protein) phosphatases II 35-238 2.1e-35 116.9 In-house 2-150 (151) alignment 
Range on Protein: 35-238
Range on HMM: 2-150/151.0
DSDYINASFIHGYdgtprsFIASQGPLPpafeGFWRMVWEQNSQSIVMLTNLVELGktKCHKYWPDKTetyggvtvtlhqseifadyeirtfilskakrs
 |||||.|.. |.      ...|.|||.     |.....|.. ..||.|....| |  .|..|.|.                                  
lsdyinfsyvtgg......lyrsggpla....dflellkelgiktivnlrseeerg..ycpeylpelg................................

gsRMVRQFHFTVWPDKGVPQYATAVLAFRRKVRAlnpRDAGPVIVHCSAGVGRTGAYIVIDAMLEQakksrtVDIRNYLIALRKDRPHMVQTKEQYSFIH
  . |...... ||| |.|..  |||.| .....    . |||.||||||.||||. .... ||..      |..   |  .|. ||..||...|. |..
..ievlhipildwpdpglplsfdavleflellld...kkngpvlvHCsaGkgRTGtlvalylmllg......vsleealeeyrlkrpgvvqpnqqflfql

SAVL
 |.|
fall
subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 8-249 1e-34 114.5 In-house 52-297 (310) alignment 
Range on Protein: 8-249
Range on HMM: 52-297/310.0
NKNKNRYANIVAYDHSRVVLErVNGDEDSDYINASFIHGyDGTPRSFIASQGPLPPAFEGFWRMVWEQNSQSIVMLTNLVELGKTKCHKYWPD--KTETY
.  ||||...|  | ||| |. ..     ||| | ...  .    .|| |||||  .   ||||.... ..||..| . .| |. ||  |||    ||||
ymhknrysdvvcldtsrvklk.idksryedyihanyvkt.nylrstficsqgplqhtiidfwrmifqeraesilllckvgeegrpkcvgywpslgvtety

GGVTVTlHQSEIFADYEIR----TFILSKAK------RSGSRMVRQFHFTVWPDKGVPQYATAVLAFrrkvRALNPRDAGPVIVHCSAGVGRTGAYIVID
| . ||   ||   ..||     ||.  .              |   ..  |||.|||.     .      | |     ||..||||||..|... . ..
gcirvt.nlsesseefeicnlavtfvpdnvpvdeqpanlkelrvslikwpnwpdrgvpdekchtvpq....rllaqvrhgpcvvhcsagkdrlyvvvalk

AMLEQAKKSRTVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVLeALTCGNTEIQ
  ......   ||. .    |.|.|   .||. || .|.   . ... |.||. 
lkidkldrglkvdaeevktellksraiciqtelqyliidrvri.ifargeteva
subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 9-247 3.1e-34 113.1 In-house 44-282 (312) alignment 
Range on Protein: 9-247
Range on HMM: 44-282/312.0
KNKNRYANIVAYDHSRVVLervNGDEDsDYINASFIHGYdGTPRSFIASQGPLPPAFEGFWRMVWEQNSQSIVMLTNLVELGKTKCHKYWPDKTetyGGV
|. ||| ||  .|  |  |    |||.  || | |..     |  |...||||  .   ||...    | ||..|. .|| |  || ||  |     | |
kdlnrypniqcwdrgrftl...agden.fyihanfvkic.tkperfvctqgplentcthfwqlalslgstsiillcgfvedgsekcakyisdiv...gfv

TVTLHQ--SEIFADYEIR--------TF---ILSKAKRSGSRmVRQFHFTVWPDKGVPQYATAVLafrRKVRALNpRDAGPVIVHCSAGVGRTGAYIVID
 .  |.  .|  .. ||              .. ||    |. . .. .. |||.|.|.   . |   | . |.. .|  ||| ||||||||||. ..|.
dledhrvyteycteieiggkskdkithrvlkvvvkatgqesk.lnhyqwaswpdhgmpdscdtal...rllsavk.kdkkpviahcsagvgrtgtlalie

AMLEQAKKSRTVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVLEALTCGNTE
.|.   .. |  .... .. |||||   |..  || .   .||| | .    
smiaalrhprkqnvkdsfvllrkdrarsvrvfpqyvyalrcvleflyskgly
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 135-275 1.4e-33 110.8 In-house 87-228 (440) alignment 
Range on Protein: 135-275
Range on HMM: 87-228/440.0
GSRMVRQFHFTVWPDKGVPQYATAVLAFRRKVRALN-PRDAGPVIVHCSAGVGRTGAYIVIDAMLEQAKKSRTVDIRNYLIALRKDRPHMVQTKEQYSFI
 || ..|.|.  |||||||..|  || . . |   .     ||..||||||.||||  |..|..| .||.|  .|| ... ..|..||.|||| |||.|.
esrtlkqyhyqgwpdkgvpkfagpvlkmiqdvnesqekagngpllvhcsagagrtgviiavdsilreakrsdqidifsfinsmrnnrpqmvqtpeqyafv

HSAVLEALTCGNTEIQSENYNQAMQKLASVNRKFQMTGYALE
| ||||.| ||.| |  ..  . ....   | . . .    |
heavlegllcgdtliledditerveqiqwpnphtdksplqqe
PTPc_DSPc_SM00012 428-528 1.5e-33 110.4 In-house 2-104 (105) alignment 
Range on Protein: 428-528
Range on HMM: 2-104/105.0
VRHLHHVSWPDKCIPEVARSVLDLLDEVQASQQQCG-NAPVLVQCSNGVGRSGTFCAISSVIERLKTE-QVIDVFQVIKRIRANRPGAVESLTQYVFCYQ
|.|.|. .|||...|| . |.|.||..|. ...... ..||.|.||.||||.|||.|.. ....|..| . .|.||..|..|  |||.|....||.|.|.
vkhyhytgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqylflyr

IIQ
...
all
PTPc_DSPc_SM00012 139-239 2.5e-33 109.8 In-house 2-105 (105) alignment 
Range on Protein: 139-239
Range on HMM: 2-105/105.0
VRQFHFTVWPDKGVPQYATAVLAFRRKVRALNPRDA--GPVIVHCSAGVGRTGAYIVIDAMLEQAKKS-RTVDIRNYLIALRKDRPHMVQTKEQYSFIHS
|...|.| |||.|||......| . |.|.  .   .  .||.||||||||||| ....| .|.| .|. ..||| ... .||| ||.||||.|||.|.. 
vkhyhytgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqylflyr

AVLE
|.||
alle
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 3-165 3.1e-33 109.9 In-house 28-192 (297) alignment 
Range on Protein: 3-165
Range on HMM: 28-192/297.0
ARKPANKNKNRYANIVAYDHSRVVLERVNgdEDSDYINASFIHGY-DGTPRSFIASQGPLPPAFEGFWRMVWEQNSQSIVMLTNLVELGKTKCHKYWPDK
|....   |||| .|.|.| .|| | ||    ..||||| ..    . ..  .| .||||  . . ||..|.||. . |||...| | |. ||  |||. 
akrnsslrknryrdilatddtrvkllrvi..terdyinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmvaklqedGrdkcapywpsv

TE--TYGGVTVTLHQSEIFADYEIR-TFILSKAKRSGSRMVRQFHFTVWPDKGVPQYATAVLAFRRK
 .     |  |  . |.   ...      |    || ||.||   |  |||.|||     .  |. .
vqerlkagdvvveflsstsdefdrviltelqliyrsesrvvrhvqflswpdhGvpsdledlvrfqaq
subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 343-526 1.9e-32 107.1 In-house 5-199 (199) alignment 
Range on Protein: 343-526
Range on HMM: 5-199/199.0
NAFIATQHPLQHTIEDFWRMVTDYDIGTIVMLNNLHEHDQ-EYPQYLPV--EGATKYGHIRVSLLSKQEKGDVISTKLKVTRNK----KTHEVRHLHHVS
  .|||||||..|. |||.|| .   | |||.|.     . .|| | |.   |..||| . |.  .   | |   | | .| |      | |. |    |
rryiatqhplretmadfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqfts

WPDKCIPEVARSVLDLL--DEVQASQQQCGNAPVLVQCSNGVGRSGTFCAISSVI---ERLKTeQVIDVFQVIKRIRANRPGAVESLTQYVFCYQI
| .|  |.||  |  ..   ||    .|  .|||.|.||.| | .| | |.   .   |  ||  |.|.|.| ||.|  | | . || .| | ||.
wkekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheeskt.svvdlfevakrlrqarcgiisslqhynfiyqv
subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 343-526 2e-32 107.0 In-house 4-198 (198) alignment 
Range on Protein: 343-526
Range on HMM: 4-198/198.0
NAFIATQHPLQHTIEDFWRMVTDYDIGTIVMLNNLHEHDQ-EYPQYLPV--EGATKYGHIRVSLLSKQEKGDVISTKLKVTRNK----KTHEVRHLHHVS
  .|||||||..|. |||.|| .   | |||.|.     . .|| | |.   |..||| . |.  .   | |   | | .| |      | |. |    |
rryiatqhplretladfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqfts

WPDKCIPEVARSVLDLL--DEVQASQQQCGNAPVLVQCSNGVGRSGTFCAISSVI---ERLKTeQVIDVFQVIKRIRANRPGAVESLTQYVFCYQI
| .|  |.||  |  ..   ||    .|  .|||.|.||.| | .| | |.   .   |  ||  |.|.|.| ||.|  | | . || .| | ||.
wkekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheeskt.svvdlfevakrlrqarcgiisslqhynfiyqv
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 296-531 3e-32 106.6 In-house 44-287 (305) alignment 
Range on Protein: 296-531
Range on HMM: 44-287/305.0
EKPQNLHKNRFSDIIALNSCRVMLHKEHAdeeSDYINAVFLHVRMERNAFIATQHPLQHTIEDFWRMVTDYDIGTIVMLNNLHEHD-QEYPQYLPVEGAT
 . |. .|||. |.  |.  || |.        .|| | ..    . . || || ||..|  ||| |  .  . .| || || |.  .   .|.. .   
keaqeagknrykdvgcldnnrvklegpwp...heyihanyvstptnpkrfictqaplektcadfwymclqdkveaifmlcnllekgakkcleyfaskdkd

------KYGHIRVSL-------LSKQEKGDVISTKLKVTR-NKKTHEVRHLHHVSWPDKCIPEVARSVLDLLDEVQASQqqcgnAPVLVQCSNGVGRSGT
      |  .| | .       . |. | .|  |.| .    .|.. | | | . |||. .|    ..|.|| . ..|.      |. | || |.||.|.
vlefeekgqkisvkfessvtlkfrkdakakvtetvlviegpgekarkvthyhwidwpdrgvpaadlailellekarpsk.....gpivvhcsagigrtgs

FCAISSVIERLKTEQVID-VFQVIKRIRANRPGAVESLTQYVFCYQIIQKYL
   .  ....| . |.|.   .....|| .|  .... .||.| .|.| .|.
vvmleyildqllagqiiedtdkilqkireqrnnsiqtdaqylfvhqvilnyf
subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 7-241 1.1e-31 104.9 In-house 34-270 (285) alignment 
Range on Protein: 7-241
Range on HMM: 34-270/285.0
ANKNKNRYANIVAYDHSRVVLErvngDEDSDYINASFIHGYDGTPRSFIASQGPLPPAFEGFWRMVWEQNSQSIVMLTNLVELGKTKCHKYWPDKTE---
|| . ||||.. . . .||||.    . | ||| ||...       ..|..||||| ..  ||.|.....   ..||  |.| |  ||  |.|.|     
anpdlnryadvrcieetrvvlk....nhdrdyihaswmrmpgkdqstyittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekcalyypeklgevv

TYGGVTVTL--HQSEIFADYEIRTFILSKAKRSGSRMVRQFH--FTVWPDKGVPQYATAVLAFRRKVRALNPRDAgPVIVHCSAGVGRTGAYIVIDAMLE
 .|   .||   . |  |   . .. . ... . |  .   |     |||.  |. |  .. . . |. .||..  |. |||||||||| ... ||    
kfgkyeitlteckeeaiagtilnaltvintedasseplymnhvqvpwwpdqlapedarpmielykwvkkvnpkek.picvhcsagvgrtatfvgidyati

QAKKSRTVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVLEAL
.  .   ... . .  .|  | . ||.. |. |..  ..| .
rimenpniemldivremramrfqavqshmqflflyvvlmeyf
subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 283-529 4.3e-31 102.6 In-house 20-267 (281) alignment 
Range on Protein: 283-529
Range on HMM: 20-267/281.0
TSREIPAEEKSVGEKPQNLHKNRFSDIIALNSCRVMLHK-EHADEESDYINAVFLHVRMERNAFIATQHPLQHTIEDFWRMVTDYDIGTIVMLNNLHEHD
   . |..  .| ..| | .|||...| .|.  || |.      . .||| | ...  . .  .| || | . |  |||||. . .  .|||| .. | .
lpgdppsdlctvfnqpvnnkknrylnipcldisrvqlkvkmpnknstdyihanyirspflkrgyiltqgpkketradfwrmiwqenttaivmlcqfletn

QEY-PQYLPVEG--ATKYGHIRVSLLSKQEKGDVISTKLKVTRNKKTHEVRHLHHVSWPDKCIPEVARSVLDLLDEVQASqqqcgNAPVLVQCSNGVGRS
.|   .|.| .   . .. .. ||      .  ...|.|... . .|. . |     |||  .|| .  .| .| ...|       .| ...|| |||||
rekcaeyfprnahcclqfdklsvsyedstvnkslvttrlnlsyegetrlithwlwkewpdwqvpessevmlkilrkirar.....stppvihcsagvgrs

GTFCAISSVIERLKTEQ-VIDVFQVIKRIRA-NRPGAVESLTQYVFCYQIIQK
||. |.   .. ...   . |. |.. ..|   |  .|..| ||.. ....  
gtlmaveialqsihshftlpdikqivshlrvtgraasvqtlqqymliwkvlld
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 300-531 8.5e-31 101.7 In-house 55-289 (305) alignment 
Range on Protein: 300-531
Range on HMM: 55-289/305.0
NLHKNRFSDIIALNSCRVMLHKEHadeESDYINAVFLHVRME-RNAFIATQHPLQHTIEDFWRMVTDYDIGTIVMLNNLHEHD-QEYPQYLPVEGATK--
.  |||..|. . .   | |.|      |||| | .. . |   . ||..| ||..||..|| || .  .  |||| .  |       || |.    |  
aitknryqdvpcqdqsavkldkps...psdyihanyvgcpmipekrficaqgpldqtidefwwmviqnkveqivmlcktvelgklkcaqywpaaqgekle

-YGHIRVSLLSKQ----EKGDVISTKLKVTR-NKKTHEVRHLHHVSWPDKCIPEVARSVLDLLDEVQASQqqcgnAPVLVQCSNGVGRSGTFCAISSVIE
  . | |  .|         ..  | |..|   ...  ||||.   |||. .| .  . |.||  .. |.      |..|.|| |.||.||  ||  ..|
lksgivvenvsgskpmerdaeiqitllnltysgdqkmsvrhlqwtewpdrgvppckltslellsairgsk.....vpivvhcsagigrtgtivaieyile

RLKTE-QVIDVFQVIKRIRANRPGAVESLTQYVFCYQIIQKYL
..  . ..  . ...| .| .|  ....  ||.| .... .|.
kiaenkpcppmpelvkalrdqrafsiqndvqylfihrvmlnyf
subfamily_ptpA1_pd Subfamily ptpA1 287-491 1.8e-30 101.0 In-house 34-256 (418) alignment 
Range on Protein: 287-491
Range on HMM: 34-256/418.0
IPAEEKSVGEKPQNLHKNRFSDIIALNSCRVMLHKEHADEESDYINAVFLHVRMERnAFIATQHPLQHTIEDFWRMVTDYDIGTIVMLNNLHE-----HD
.   | | |.| .|  |||...|. .|  || |.| .  | |||||| ..     .  ||.|| ||  || |||||| .     ||||.   |      |
vgpsetsegdkkhntsknrytnilpvnhtrvqlkkiqdkegsdyinanyidgaypk.qfictqgplpntiadfwrmvwenrcriivmlsresencrikcd

QEYPQYLPVEGATK-------YGHIRVSLLS--KQEKGDVISTKLKVTRNKKTHEVRHLHHVSWPDKCIPEVARSVLDLLDEVQASQQQC-----GNAPV
. .|. .  |  .        .|   | |.   .. . ..|. ....| . .|... . ..  |||. ||. .. . .||  .   |.|       | |.
rywpeqiggeqfsiygngnevfgtysvelveviqdpereiitrnirltfegetrditqyqyegwpdhnipdhtqpfrqllhsitnrqnqiipssdrnvpi

LVQCSNGVGRSGTFCAISSVIERL
.|.|| ||||.||||.   ....|
ivhcsagvgrtgtfctavimmkkl
0051082 (Phosphotyrosine protein) phosphatases II 328-527 3.6e-30 99.9 In-house 3-149 (151) alignment 
Range on Protein: 328-527
Range on HMM: 3-149/151.0
SDYINAVFLHVRmernaFIATQHPLQhtieDFWRMVTDYDIGTIVMLNNLHEHDqEYPQYLPVEGatkyghirvsllskqekgdvistklkvtrnkktHE
|||||. ..  .     ......||.    ||.... ...| |||.|....|..  .|.||| .|                                 .|
sdyinfsyvtgg.....lyrsggpla....dflellkelgiktivnlrseeerg.ycpeylpelg.................................ie

VRHLHHVSWPDKCIPEVARSVLDLLDEVQAsqqqCGNAPVLVQCSNGVGRSGTFCAISSVIERlkteqvIDVFQVIKRIRANRPGAVESLTQYVFCYQII
|.|.. ..|||  .|.   .||..|.....    ..| |||| || |.||.||..|.  ....      ........ .|. |||.| . .|..|... .
vlhipildwpdpglplsfdavleflellld....kkngpvlvHCsaGkgRTGtlvalylmllg......vsleealeeyrlkrpgvvqpnqqflfqlfal
subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 8-259 6e-30 99.0 In-house 50-298 (301) alignment 
Range on Protein: 8-259
Range on HMM: 50-298/301.0
NKNKNRYANIvAYDHSRVVLERVNGDedSDYINASFIHGYdGTPRSFIASQGPLPPAFEGFWRMVWEQNSQSIVMLTNLVELGKTKCHKYWPDKTET---
.|.|.|| ..   . |  |   |.|      | | .|    | |. |||.||||. . | || |.   . . ||||.. ||  ..||..| | |..    
pkdkhryptv.PckPstavevivdGk..rvPihanwipts.GhphrfiatqgPlkntsedfwamlvqydvekivmlgqkvekleekceeylpvkisekld

YGGVTVTLHQSEIFADYEI--RTFIL-SKAKRSGSRMVRQFHFTVWPDKGVPQYATAVLAFRRKVRalnpRDAGPVIVHCSAGVGRTGAYIVIDAMLEQA
 |  .......|   . .|  ||. .   ...  .| |  . .. |.|.|||.  . .  .   |.    .   |..||||||.||. |.|  . .  . 
igrfkikiknkelilnkkiskrtlevedstgkfatrtvthyqysewtdrgvPkshaelfdlmelvk....ksekPivvhcsaGiGrsvafigteylarev

KKSRTVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVLEALTCgNTEIQSENYNQAMQK
.  .|... . |  ||..| . |||..|  ..    .  |   . ...   |.. .. 
eadptieltealkhlrehrwngvqtnsqlywmtlGtvyrlik.eygfdmkiyeeqlam
subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 300-531 7.8e-30 98.8 In-house 35-270 (285) alignment 
Range on Protein: 300-531
Range on HMM: 35-270/285.0
NLHKNRFSDIIALNSCRVMLhKEHadeESDYINAVFLHVR-MERNAFIATQHPLQHTIEDFWRMVTDYDIGTIVMLNNLHEHDQEY-PQYLPV--EGATK
|   ||..|. ...  ||.| |.|   . ||| | ....   .....|.|| ||  |. |||.|. .  |  ..||  | |   |    | |       |
npdlnryadvrcieetrvvl.knh...drdyihaswmrmpgkdqstyittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekcalyypeklgevvk

YGHIRVSLLSKQEK--GDVISTKLKVTR-NKKTHEVRHLHHV---SWPDKCIPEVARSVLDLLDEVQASQqqCGNAPVLVQCSNGVGRSGTFCAISSVIE
.|.  ..|   .|.     |   | |.  .  . |  .. ||    |||.  || || ...|   |.  .    . |. |.|| ||||. ||  |     
fgkyeitlteckeeaiagtilnaltvintedasseplymnhvqvpwwpdqlapedarpmielykwvkkvn..pkekpicvhcsagvgrtatfvgidyati

RLKTEQVIDVFQVIKRIRANRPGAVESLTQYVFCYQIIQKYL
|.  .  |....... .|| |  ||.|  |..| | .. .|.
rimenpniemldivremramrfqavqshmqflflyvvlmeyf
subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 331-520 1.9e-28 94.1 In-house 78-270 (301) alignment 
Range on Protein: 331-520
Range on HMM: 78-270/301.0
INAVFLHVRMERNAFIATQHPLQHTIEDFWRMVTDYDIGTIVMLNNLHEHD-QEYPQYLPVEGATKYGHIRVSLL--SKQE--KGDVISTKLKVTRN---
| | ..    . . ||||| ||. | |||| |.. ||. .|||| .  |.  .   .||||. . |    | ..   .|.   . ...  .|.|.     
ihanwiptsGhphrfiatqgPlkntsedfwamlvqydvekivmlgqkvekleekceeylpvkisekldigrfkikiknkelilnkkiskrtlevedstgk

KKTHEVRHLHHVSWPDKCIPEVARSVLDLLDEVQASQQqcgnaPVLVQCSNGVGRSGTFCAISSVIERLKTEQVIDVFQVIKRIRANRPGAVESLTQY
 .|. | |  ...|.|. .|.    . ||.. |. |..     |..|.||.|.||| .| .   .  ...... |.. . .|..| .|  .|   .| 
fatrtvthyqysewtdrgvPkshaelfdlmelvkksek.....PivvhcsaGiGrsvafigteylareveadptieltealkhlrehrwngvqtnsql
subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 253-525 3.4e-28 93.1 In-house 10-284 (310) alignment 
Range on Protein: 253-525
Range on HMM: 10-284/310.0
YNQAMQKLASVNRKFQMTGYALEFQRLNSVTSREIPAEeksvgEKPQNLHKNRFSDIIALNSCRVMLHKEHADeESDYINAVFLHVRMERNAFIATQHPL
| .|....     |. . | . ....|..     .  |        ...||||.||.. |...|| |. ...    ||| | ...    |..|| .| ||
ylkalenfiiateklgieglvkqyrkldakqdssltye.....aykkymhknrysdvvcldtsrvklkidksr.yedyihanyvktnylrstficsqgpl

QHTIEDFWRMVTDYDIGTIVMLNNLHEHDQEY-PQYLPVEGATK-YGHIRVSLLSKQEKGDVIStKLKVT------------RNKKTHEVRHLHHVSWPD
|||| |||||. .    .|..| .  |  .     | |  | |. || |||. ||.  .   |  .| ||             | |   |  ..   |||
qhtiidfwrmifqeraesilllckvgeegrpkcvgywpslgvtetygcirvtnlsesseefeic.nlavtfvpdnvpvdeqpanlkelrvslikwpnwpd

KCIPEVARSVLdlldeVQASQQQCGNAPVLVQCSNGVGRSGTFCAISSVIERLKTEQVIDVFQVIKRIRANRPGAVESLTQYVFCYQ
. .|.     .      |    |    |..|.|| |..| .. .|.   |..|.  . .|. .|.  .. .|   ...  ||..  .
rgvpdekchtv.....pqrllaqvrhgpcvvhcsagkdrlyvvvalklkidkldrglkvdaeevktellksraiciqtelqyliidr
0044763 (Phosphotyrosine protein) phosphatases II 314-530 6.7e-28 92.9 In-house 4-170 (178) alignment 
Range on Protein: 314-530
Range on HMM: 4-170/178.0
SCRVMLHKEHADEESDYINAVFLHvrmeRNaFIATQHPLqhtiEDFWRMVTDYDIGTIVMLNNLHEHD-QEYPQYLPVEGAtkyghirvsllskqekgdv
 .|| |..    | ||||||..       . ......|     .|..... ...|..||.|..  |.  .....| | |                     
rtrvllsnleglersdyinaseil....pg.lylgslpp....addlellkelgithivnlteelelgflkcdpywpeeag...................

istklkvtrnkkthevRHLHHVSWPDKCIPEVARSVLDLLDEVQASQQQCGnAPVLVQCSNGVGRSGTFCAISSVIERlkteQViDVFQVIKRIRANRPg
                 . .|. .|| . |.. . .|.... ... ....|  |||| || |||||||..|.  ....    .. .....|...|. || 
................iqylhipipDhgvpdllehflefvefieealdekg.gpvlVHCsaGvgRsgtlvaaylmkkl....gl.sleeaielvrerRp.

AVESLTQYVFCYQIIQKY
.|..  |. ..|.. ...
ivpnpgqlrqLyefelrl
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 285-444 2.2e-27 90.7 In-house 18-182 (297) alignment 
Range on Protein: 285-444
Range on HMM: 18-182/297.0
REIPAEEKSVGEKPQNLHKNRFSDIIALNSCRVMLHKEHadEESDYINAVFLHVRMERN--AFIATQHPLQHTIEDFWRMVTDYDIGTIVMLNNLHEHD-
.|  .|. |.  ..  |.|||. ||.| .. || | .     |.||||| ..    | .   .| .| ||. |..|||..|.. |...|||. .| |   
deargesfssakrnsslrknryrdilatddtrvkllrvi..terdyinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmvaklqedGr

-QEYPQYLP-VEGATKYGHIRVSLLSKQ--EKGDVISTKLKVTRNKKTHEVRHLHHVSWPDKCIPEV
 . .| .   |..  | |.. |  ||.   |   || |.|..   ...  |||  ..||||. .|  
dkcapywpsvvqerlkagdvvveflsstsdefdrviltelqliyrsesrvvrhvqflswpdhGvpsd
subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 299-531 3.1e-26 86.5 In-house 50-285 (302) alignment 
Range on Protein: 299-531
Range on HMM: 50-285/302.0
QNLHKNRFSDIIALNSCRVMLHKEhadeESDYINAVFLHVRMERNAFIATQHPLQHTI---EDFWRMVTDYDIGTIVMLNNLHEHDQEYPQYLP--VEGA
.||.||.  |. .|.| .| |..|    . .|.||  ..|   ..  | .| | . .    |.||||| .  | ..|.|    | ..   ...|   .  
knlkknqsedvpildsnlvkleae....pdsyvnaskvevPeltrsiilaQlpkvdsedsveeFWrmvfqekivsvvilvgeeelkktlselfpkksgdy

TKYGHIRVSLLSkQEKGDV--ISTKLKVTR----NKKTHEVRhlHHVSWPDKCIPEVARSVLDLLDEVqASQQQCGNAPVLVQCSNGVGRSGTFCAISSV
..||...|      || .       . |      |    .|   ..  |..| .|.   ..     .|   ... .......   ||.|| |.| .   .
keygkmfvNnrk.VekaeeektryviEvlPegcsnsvlanvy..vltnWkqkkvpvkyaeliktaakv.fakkikadentvivSknGaGRagafltlava

IERLKTEQVIDVFQVIKRIRANRPGAVESLTQYVFCYQIIQKYL
.|.|....   . ...| ||..|| ||.||.|||. | ..  |.
veklqkgkepnikeivksiRsqRpravdslkQyvslyialllyi
subfamily_egg_pd Subfamily egg 295-530 1.3e-25 84.7 In-house 35-269 (307) alignment 
Range on Protein: 295-530
Range on HMM: 35-269/307.0
GEKPQNLHKNRFSDIIALNSCRVMLHKEHADEESDYINAVFLHVRMERNAFIATQHPLQHTIEDFWRMVTDYDIGTIVMLNNLHEHDQeYPQYLPV---E
  .  ||.| |   .   .|.|| |. ..     |.| |  .. .   | || .| ||. | .||||||   ..  ||||.   | ..  . | |    .
aasdnnlekarskrvhckdssrvklelrrGqylddfihanrvkGkpllnefilaqaplkntvddfwrmvfqeevqyivmltsrkeser.ceyywpkaesd

GATK-YGHIRVSLLSKQEKGDVI--STKLKVTRNKktHEVRHLHHVSWPDKCIPEVArSVLDLLDEVQASqqqcgNAPVLVQCSNGVGRSGTFCAISSVI
 .    | .|.  |  ..| | .   ||||.   .  .| |.| |  .  .   .|  | | .|  ..         ||.||. .|| ...|. ||   .
slvtvpGslrienlkvdskadplfrvtklklvGgd..deerflehwqgdvnnssdvy.splrvlrklrnl.....skpvvvqdilGvskaatlvaieial

ERLKTEQV--IDVFQVIKRIRANRPGAVESLTQYVFCYQIIQKY
  |    .    | . .. .| .|. .|||  .|.| |...  .
lsllrGpitkslvlravvflrlrrrlsvesvllylfvyrlvlff
0048076 (Phosphotyrosine protein) phosphatases II 105-238 2.4e-25 84.3 In-house 13-140 (145) alignment 
Range on Protein: 105-238
Range on HMM: 13-140/145.0
YGGVTvTLHQSEIFADYEIRT-FILSKAKRSGSRMVRQFHFTVWPDKGVPQYATAVLAFRRKVRALNPRDaGPVIVHCSAGVGRTGAYIVIDAMLEqakk
.|... | .. | ..|. |.| . |.  ..  .|.. |.... ||| |||. .  .|.| . .... ... |||.|||||||||||...... ||.    
lgslp.taldlellkdlgittvlnltselellerlgiqylylpwpDhgvpdllellleflefieealkeg.gpvlVHCsaGvgRtgtlvaaylmll....

sRTVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVL
 . |.. . |  .|. ||..|.. .|. |.. ..|
.lgvsleealelvrsqrpgavpnpgqlrflyefel
subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 297-530 1.1e-24 81.6 In-house 44-278 (303) alignment 
Range on Protein: 297-530
Range on HMM: 44-278/303.0
KPQNLHKNRFSDIIALNSCRVMLHkehadeESDYINAVFLHVRMERNAfIATQHPLQHTIEDFWRMVTDYDIGTIVMLNNLHEHDQEYPQYL-PVEG-AT
  .|..|||| |.| |.  .| |       .| || | .|..  ...| | || ||.||  |||.|. .  .  ...|    |.|.   ... | .    
fvknmdknrfvdvicldhskvkls......dssyihasyleldsskka.iltqlplshtaadfwqmiieqkvkcvlllltdseydklggdsvfprnqdfl

K--YGHIRVSLLSKQEKGDVISTKLKVTRNKKTHEVRHLHHV-SWPDKCIPEV-ARSVLDLLDEVQASQQQC-GNAPVLVQCSNGVGRSGTFCAISSVIE
|     |||  . . | ||  . |.    | . .   |.||  .|| . ||   .  ..  . ..|.  ..   . | .     |.||.|||. . .   
kfeersirvgefkrvelgdgwvlkvlsvsngdyksflhvhhykawphnsipsdgspkfvkqiwqlqsvlrkysdstptvymslsgcgragtfalfetahl

RLKTEQV-IDVFQVIKRIRANRPGAVESLTQYVFCYQIIQKY
 |..||  .|. .... .|  |  ||. |.|. . | .. ..
slhseqasldlvkclenvrngrlhavqnlsqfsvvytllaeh
0048179 (Phosphotyrosine protein) phosphatases II 119-235 4.6e-24 80.2 In-house 26-139 (144) alignment 
Range on Protein: 119-235
Range on HMM: 26-139/144.0
ADYEIRTFI---LSKAKRSGSRMVRQFHFTVWPDKGVPQYATAVLAFRRKVRALNPRDaGPVIVHCSAGVGRTGAYIVIDAMLeqakkSRTVDIRNYLIA
... |.| |    .  . .  |.. |.... ||| |||.... .|.| . .... ... |||.|||||||||||...... |.      . ... . |  
kklgittvinlteeyepefleregiqylhlpwpDhgvpdllellleflefieealeeg.gpvlVHCsaGvgRtgtlvaaylmk.....klglsleealal

LRKDRPHMVQTKEQYSFIHS
.|. ||..|.. .|. |.. 
vrsrrpgavpnpgqlrfLle
subfamily_egg_pd Subfamily egg 7-238 1e-23 78.5 In-house 39-267 (307) alignment 
Range on Protein: 7-238
Range on HMM: 39-267/307.0
ANKNKNRYANIVAYDHSRVVLERVNGDEDSDYINASFIHGYDgTPRSFIASQGPLPPAFEGFWRMVWEQNSQSIVMLTNLVELgkTKCHKYWPDKT-ETY
 |..| |   .   | ||| ||  .|    |.| |  ..|       || .| ||  . . |||||.... | |||||  .|    .|. |||    .. 
nnlekarskrvhckdssrvklelrrGqylddfihanrvkGkp.llnefilaqaplkntvddfwrmvfqeevqyivmltsrkes..erceyywpkaesdsl

GGVTVTLHQSEIFADYEI-RTFILSKAKRSGSRmVRQFHFTVWpdKGVPQYATAVLAFRRKVRALNpRDAGPVIVHCSAGVGRTGAYIVIDAMLEQAKKS
  |  .|.   .  | .    | ..| |  |.    . .   |  .|  .... |    | .| |  . . ||.|..  || .... . |.  | .  . 
vtvpGslrienlkvdskadplfrvtklklvGgd.deerflehw..qgdvnnssdvysplrvlrklr.nlskpvvvqdilGvskaatlvaieiallsllrG

RT--VDIRNYLIALRKDRPHMVQTKEQYSFIHSAVL
 .    ...    ||. |.  |..  .| |..  ||
pitkslvlravvflrlrrrlsvesvllylfvyrlvl
subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 52-234 2.2e-23 77.5 In-house 5-197 (199) alignment 
Range on Protein: 52-234
Range on HMM: 5-197/199.0
RSFIASQGPLPPAFEGFWRMVWEQNSQSIVMLTNLVELGKTKCHKYWPD---KTETYGGVTVTLHQSEIFADYEIRTFILSKAKR--SGSRMVRQFHFTV
| .||.| ||  ..  ||.||||  |  |||. .     ..    |||     |  || ..|| .     .|| | ..||..       .| . .. || 
rryiatqhplretmadfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqfts

WPDKGVPQYAT---AVLAFRRKVRALNPRDAGPVIVHCSAGVGRTGAYIVIDAMLEQAKKSRT--VDIRNYLIALRKDRPHMVQTKEQYSFIH
| .|  |. |     |.| |   .  .     ||||||| | | || .. .|  .   ..|.|  ||. .    ||. |  .. . ..| ||.
wkekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiy
subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 52-234 2.4e-23 77.4 In-house 4-196 (198) alignment 
Range on Protein: 52-234
Range on HMM: 4-196/198.0
RSFIASQGPLPPAFEGFWRMVWEQNSQSIVMLTNLVELGKTKCHKYWPD---KTETYGGVTVTLHQSEIFADYEIRTFILSKAKR--SGSRMVRQFHFTV
| .||.| ||  ..  ||.||||  |  |||. .     ..    |||     |  || ..|| .     .|| | ..||..       .| . .. || 
rryiatqhplretladfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqfts

WPDKGVPQYAT---AVLAFRRKVRALNPRDAGPVIVHCSAGVGRTGAYIVIDAMLEQAKKSRT--VDIRNYLIALRKDRPHMVQTKEQYSFIH
| .|  |. |     |.| |   .  .     ||||||| | | || .. .|  .   ..|.|  ||. .    ||. |  .. . ..| ||.
wkekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiy
subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 352-528 1.4e-22 75.0 In-house 39-218 (255) alignment 
Range on Protein: 352-528
Range on HMM: 39-218/255.0
LqhTIEDFWRMVTDYDIGTIVMLNNLHEH-DQEYPQYLPVEGATKYGHIRVSLLSKQEKGDVISTKLKVT----RNKKTHEVRHLHHVSWPDKCIPEVAR
|  |.. |....   .  ..||| ...|.  ..  .|.|.|   |     |.. . .   ||.   |..|    . ||||.|.| ..  |..|  || ||
l..tvdkfyqtivqtktevvvmlcdfaeegvekcssyfplekdeklkladvnvtttkssadvvlrtleitstlgekkkthtvkhysykGWieknaPelar

SVLDLLDEVQASQqqcgnaPVLVQCSNGVGRSGTFCAISSVIE----RLKTEQV--IDVFQVIKRIRANRPGAVESLTQYVFCYQIIQ
 .| .|  |. |.      .|.|.||.|.||| .|  . .|       |.| .   .|  .... .| .|..|..   |  |.  .. 
eilnilkvvrdsk......svvvhCstGiGrsaafvlaelvyqkmirsldttetveldylslleelrskrkraihtPlqlafsilmvl
subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 7-238 2.3e-22 73.8 In-house 50-282 (302) alignment 
Range on Protein: 7-238
Range on HMM: 50-282/302.0
ANKNKNRYANIVAYDHSRVVLERvngdEDSDYINASFIHGYDGTpRSFIASQGPLPP---AFEGFWRMVWEQNSQSIVMLTNLVELGKtKCHKYWPDKTE
.| .||.  .. ..|. .| ||     |  .|.||| ..  . | || | .| |      . | |||||.... .|.|.|    || |   ....| |..
knlkknqsedvpildsnlvklea....epdsyvnaskvevPelt.rsiilaQlpkvdsedsveeFWrmvfqekivsvvilvgeeelkk.tlselfpkksg

T---YGGVTVTLHQSEIFADYEiRTFIL--SKAKRSGSRMVRQFHFTVWPDKGVPQYATAVLAFRRKVRALNPRDAGPVIVHCSAGVGRTGAYIVIDAML
.   || . |   . |   . .   ...       | | ..   ..| |..| ||.  ... .   || |..     ....    |.|| || ..  . .
dykeygkmfvNnrkVekaeeek.tryviEvlPegcsnsvlanvyvltnWkqkkvpvkyaeliktaakvfakkikadentvivSknGaGRagafltlavav

EQAKKSRTVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVL
|. .|.  . | . ....|..||..|.. .|| ... |.|
eklqkgkepnikeivksiRsqRpravdslkQyvslyiall
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 424-528 3.2e-22 73.5 In-house 87-191 (440) alignment 
Range on Protein: 424-528
Range on HMM: 87-191/440.0
KTHEVRHLHHVSWPDKCIPEVARSVLDLLDEVQASQQQCGNAPVLVQCSNGVGRSGTFCAISSVIERLKTEQVIDVFQVIKRIRANRPGAVESLTQYVFC
... ... |. .|||| .|..|  || ....|. ||...||.|.||.|| |.||.|   |. |..   |  . ||.| .|. .| |||  |..  ||.| 
esrtlkqyhyqgwpdkgvpkfagpvlkmiqdvnesqekagngpllvhcsagagrtgviiavdsilreakrsdqidifsfinsmrnnrpqmvqtpeqyafv

YQIIQ
.. . 
heavl
0048076 (Phosphotyrosine protein) phosphatases II 403-530 5e-22 73.6 In-house 36-142 (145) alignment 
Range on Protein: 403-530
Range on HMM: 36-142/145.0
LlskqekgdvistklKVTRNKKTHEVRHLHHVSWPDKCIPEVARSVLDLLDEVQASQQQcgNAPVLVQCSNGVGRSGTFCAISSVIErlktEQvIDVFQV
|                ...  .... ......||| ..|. .. .|..|. ... ...  . |||| || ||||.||..|.  ...    .. ......
l..............tselellerlgiqylylpwpDhgvpdllellleflefieealke..ggpvlVHCsaGvgRtgtlvaaylmll....lg.vsleea

IKRIRANRPGAVESLTQYVFCYQIIQKY
....|. |||||..  |. |.|. ....
lelvrsqrpgavpnpgqlrflyefelel
0048179 (Phosphotyrosine protein) phosphatases II 401-525 7.5e-22 73.0 In-house 22-139 (144) alignment 
Range on Protein: 401-525
Range on HMM: 22-139/144.0
VSLLSKQEKGDVISTKLKVTRNKKTHEVRHLHHVSWPDKCIPEVARSVLDLLDEVQASQQqcGNAPVLVQCSNGVGRSGTFCAISsvieRLKTEQvIDVF
. || |.  . ||.   .   .  ..|. ...|..||| ..|. .  .|..|. ... ..   . |||| || ||||.||..|.     ..|... ....
lellkklgittvinlteeyepefleregiqylhlpwpDhgvpdllellleflefieeale..eggpvlVHCsaGvgRtgtlvaay....lmkklg.lsle

QVIKRIRANRPGAVESLTQYVFCYQ
......|. |||||..  |. |...
ealalvrsrrpgavpnpgqlrfLle
subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 312-527 8.1e-22 72.7 In-house 30-255 (290) alignment 
Range on Protein: 312-527
Range on HMM: 30-255/290.0
LNSCRVMLHKEHADEESDYINAVFLHVRmERNAFIATQHPLQHT-------IEDFWRMVTDYDIGTIVMLNNLHEHDQEYP-----QYLP--VEGATKYG
..  ||.|.       .||| | .. .  .  ..|.|| |....       ||.|| |. .  .  .||| . .|....       .| |  |..  |..
veatrvvLkgygkrfnddyiHAnrvtcp.nglrliltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCakYvpesvgeelkfk

HIRVSLLSKQEKGDVISTKLKVTRN-KKTHEVRHLHHVSWPDKCIPEVARSVLDLLDEVQasqqqCGNAPVLVQCSNGVGRSGTFCAISSVIERLK-TEQ
 . |.  || .. ||.  .| |. . .. . | |   ..| .  ..|  ...|.|.. |.     . ..||.| | .|. || .. ||      .  |..
gltvkCkskekeddvetRelvvkfddeeeftvtHsllkgWnklnvqedtktllsliqkvk.....asktpvivHcvdGiSrsAalaaiilgyQkiaetsg

VIDVFQVIKRIRANRPGAVESLTQYVFCYQII
 . . .|.| .| .|  |. | ... |    |
svkledvlkalrkqralaitsalelafvdagi
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 10-113 1e-21 72.0 In-house 49-163 (350) alignment 
Range on Protein: 10-113
Range on HMM: 49-163/350.0
NKNRYANIVAYDHSRVVLER--------VNGDEDSDYINASFIHGY----DGTPRS-FIASQGPLPPAFEGFWRMVWEQNSQSIVMLTNLVELGKTKCHK
 |||| ||. |.|||| |..            . .|||||....      .  |   .|| |.||| ... |.... . . . |..||..|||.  ||..
aknrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvkvilsltsdvelnlekcyr

YWPDKteTYGGVTVTLH
||..   .| ..|| | 
YWqeg..sydditvkla
subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 304-535 2e-21 71.0 In-house 47-280 (312) alignment 
Range on Protein: 304-535
Range on HMM: 47-280/312.0
NRFSDIIALNSCRVMLhkehADEESDYINAVFLHVRMERNAFIATQHPLQHTIEDFWRMVTDYDIGTIVMLNNLHEHDQEY-PQYLP-VEGATKYGHIRV
||. .|   .  |  |    | .|  || | |...    . |..|| ||. |.  ||...      .|..|  . |   |   .|.  . |  .    ||
nrypniqcwdrgrftl....agdenfyihanfvkictkperfvctqgplentcthfwqlalslgstsiillcgfvedgsekcakyisdivgfvdledhrv

SL-------LSKQEKGDVISTKLKVTRNKKT--HEVRHLHHVSWPDKCIPEVARSVLDLLDEVQASQQqcgnaPVLVQCSNGVGRSGTFCAISSVIERLK
         .  . |  .    |||  .       . |    ||||. .|.   . | ||  |.  ..     ||. .|| ||||.||.. | |.|  |.
yteycteieiggkskdkithrvlkvvvkatgqesklnhyqwaswpdhgmpdscdtalrllsavkkdkk.....pviahcsagvgrtgtlaliesmiaalr

TEQVIDVFQVIKRIRANRPGAVESLTQYVFCYQIIQKYLDSFS
  .  .| ..   .| .|  .|. . |||.. ... ..| | .
hprkqnvkdsfvllrkdrarsvrvfpqyvyalrcvleflyskg
subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 349-530 4.6e-21 69.5 In-house 97-287 (302) alignment 
Range on Protein: 349-530
Range on HMM: 97-287/302.0
QHPLQHTIEDFWRMVTDYDIGTIVMLNNLHEHD-QEYPQYL--PVEGATKYGHIRVSLLSKQEKGDVIS-------TKLKVTRNKKT----HEVRHLHHV
  | . |.| .| .. .|... .| | .. | . . . .|    |.|  |.|.  |  .| ... .  .        ..... .||.    . |  |.. 
ivpkkstlekhwalieqynvaivvqlcsfvedeekkcaeyysdkvggelkfgrytvktvsvktdleeftdkksfklytveiknekkkkkvkktvdilafs

SWPDKCIPEVARSVLDLLDEVQASQQQcgnapVLVQCSNGVGRSGTFCAISSVIERLKTEQVIDVFQVIKRIRANRPGAVESLTQYVFCYQIIQKY
.|||.  |. | . ||.|   .. ...     ||| ||.||||.||. ||   |.  ....| |. .... .|. | ||| . .| ..   .. | 
awpdhGapkeaytaldilkfcesykkn.....vlvhcsaGvGrtGtlvaikyGiqlcskkkvtdllsivlpvrqcryGavqdeqqliylllcvtkg
subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 64-248 4.9e-21 69.9 In-house 40-227 (255) alignment 
Range on Protein: 64-248
Range on HMM: 40-227/255.0
AFEGFWRMVWEQNSQSIVMLTNLVELGKTKCHKYWP---DKTETYGGVTVTLHQseIFADYEIRTFILS-K-AKRSGSRMVRQFHFTVWPDKGVPQYATA
. . |....  .... .|||... | |. ||..|.|   |.   .  |.||  .    ||  .||  .  . ...   . |. .... |..|  |. |  
tvdkfyqtivqtktevvvmlcdfaeegvekcssyfplekdeklkladvnvtttk..ssadvvlrtleitstlgekkkthtvkhysykGWieknaPelare

VLAFRRKVRalnprDAGPVIVHCSAGVGRTGAYIVIDAM----LEQAKKSRTVDI--RNYLIALRKDRPHMVQTKEQYSFIHSAVLEALtCGNTEI
.|   . ||     |. .|.||||.|.||. |..... .    . . ... ||..  .. |  ||. |.  ..|  | .|    ||. .   ..|.
ilnilkvvr.....dsksvvvhCstGiGrsaafvlaelvyqkmirsldttetveldylslleelrskrkraihtPlqlafsilmvldlv.fpkgel
subfamily_hpo-7_pd Subfamily hpo-7 352-527 3e-20 67.2 In-house 43-223 (263) alignment 
Range on Protein: 352-527
Range on HMM: 43-223/263.0
LQHTIEDFWRMVTDYDIGTIVMLNNLHEHD-QEYPQYLPVEGATKYGHIRVSLLSKQEKGDVISTKLKVTR----NKKTHEVRHLHHVSWPDKCIPEVAR
|  ||. |....      ..||| . .|.. ..  .|.|.|   |     |.. . . . ||.   |...      ||||.|.|  .. |..|  || ||
lvqtidkfyqtivqtktevvvmLcDfneegvekcssyfPlekdekqklanvnvcttkvqsdvllktlellstlgeKkkthtvkhysykgWiekndpelar

SVLDLLDEVQASQqqcgnaPVLVQCSNGVGRSGTFCAISSVIE----RLKTEQV--IDVFQVIKRIRANRPGAVESLTQYVFCYQII
..| .|. .. |.      .. | ||.|.|||  |  . .|       |.| .   .|  .... .| .|..|..   |  |   ..
eilnilkvarnsk......slvvhcstGiGrsaafsvaElvyqkmirsldttstveldylsLleelrssrkraihtPmqLafsilmv
subfamily_CG42327_pd Subfamily CG42327 301-458 7e-20 65.9 In-house 29-193 (319) alignment 
Range on Protein: 301-458
Range on HMM: 29-193/319.0
LHKNRFSDIIALNSCRVMLHKEHADEESDYINAVFLH-VRMERNAFIATQHPLQHTIEDFWRMVTDYDIGTIVMLNNLHEHD-QEYPQYLPV----EGAT
  |.|. ... |   ||.|..   |... |..| ..   .  .| .||.| .|. .  ||||.| .    .|| | .|.|   .  ..|||     ..  
kdksrvinvvPlPetrvvlqrigdddkdeyldasyvrGyddapnsyiaaqvsledsssdfwrtvweqqsrvivqltdlselGikvcaeylPtketldnts

KYGHIRVSLLSKQEKGD-VISTK-LKVTRNKKTHEVRHLHHvSWPDKCIPEVARSVLDLLDEVQAS
 ||.|.|.|  .. |   .|||  ||   .... |. |  .  |..  .|   .... .| ||..|
lyGdilvtlkgrevkdryaistlllkrvdkeesrelthywy.kwleaevPaeeaaliamllevrss
subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 11-260 1e-19 65.8 In-house 22-279 (290) alignment 
Range on Protein: 11-260
Range on HMM: 22-279/290.0
KNRYANIVAyDHSRVVLERVNGDEDSDYINASFIHGYDGTprSFIASQGPLPPA-------FEGFWRMVWEQNSQSIVMLTNLVELGKT----KCHKYWP
..|... ..  ..||||.       .||| |...   .|    .|..| |.           | || |. . .....||| .  |  .      | || |
dqRlevpLv.eatrvvLkgygkrfnddyiHAnrvtcpngl..rliltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCakYvp

DKTE---TYGGVTVTLHQSEIFADYEIRTFILSKAKRSgSRMVRQFHFTVWPDKGVPQYATAVLAFRRKVRalnpRDAGPVIVHCSAGVGRTGAYIVIDA
.. .   ...|.||   . |   | |.|. ..   ..     |    .  | .  |..    .|.  .||.        ||||||  |. |  |   |. 
esvgeelkfkgltvkCkskekeddvetRelvvkfddee.eftvtHsllkgWnklnvqedtktllsliqkvk....asktpvivHcvdGiSrsAalaaiil

MLE-QAKKSRTVDIRNYLIALRKDRPHMVQTKEQYSFIHSAV-LEALTCGNTEIQSENYNQAMQKL
     |..|  | ... | |||| | ..........|.  .. | |   ... ...|. ..|... 
gyQkiaetsgsvkledvlkalrkqralaitsalelafvdagivllaievldqfaeeetekkakaee
subfamily_hpo-7_pd Subfamily hpo-7 64-276 2.1e-18 61.2 In-house 46-260 (263) alignment 
Range on Protein: 64-276
Range on HMM: 46-260/263.0
AFEGFWRMVWEQNSQSIVMLTNLVELGKTKCHKYWP---DKTETYGGVTVTLHQSEIfaDYEIRTFILSK--AKRSGSRMVRQFHFTVWPDKGVPQYATA
. . |....  .... .|||..  | |. || .|.|   |.   .  |.|.  ..    |  ..|  | .   ..   . |... .. |..|  |. |  
tidkfyqtivqtktevvvmLcDfneegvekcssyfPlekdekqklanvnvcttkvqs..dvllktlellstlgeKkkthtvkhysykgWiekndpelare

VLAFRRKVRalnprDAGPVIVHCSAGVGRTGAYIVIDA----MLEQAKKSRTVDI--RNYLIALRKDRPHMVQTKEQYSFIHSAVLEALTCGNTEIQSEN
.|   . .|     .  ...||||.|.||. |. |..     |. . ... ||..  .. |  ||. |.  ..|  | .|    ||. .   ... . | 
ilnilkvar.....nskslvvhcstGiGrsaafsvaElvyqkmirsldttstveldylsLleelrssrkraihtPmqLafsilmvLdfvlnnfakgelea

YNQAMQKlaSVNRKFQMTGYALEF
  | ..|  |  .  ||    |||
kyqeirk..sylharqmmhkdlef
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 284-400 4e-18 60.2 In-house 31-161 (350) alignment 
Range on Protein: 284-400
Range on HMM: 31-161/350.0
SREIPAEEKSVGEKPQNLHKNRFSDIIALNSCRVMLH--------KEHADEESDYINAVFLHVR---MERN-A--FIATQHPLQHTIEDFWRMVTDYDIG
. | | ..  . |  .   |||...|.  .  || |.        |.|. . .||||| .|..    .| |    .|||| ||. |..||.....  .. 
dsespsnDvilseGvelfaknrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvk

TIVMLNNLHEHDQEY-PQYLPvEGATKYGHIR
 |..|... |.. |   .| . ||. .  ...
vilsltsdvelnlekcyrYWq.egsydditvk
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 164-241 1.2e-17 58.7 In-house 219-295 (297) alignment 
Range on Protein: 164-241
Range on HMM: 219-295/297.0
RKVRALNPRDAgPVIVHCSAGVGRTGAYIVIDAMLEQAKKSRTVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVLEAL
  .||  ||.| ...|||||||||.|  .  |..|.. .| |  |..  |  ||. |. .||| ||. ....|||. |
eslraemprna.yllvhcsaGvGrsGvvvlsdvilaklrkkripdvaailsilreqrarlvqtleqfellydavlkkl
subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 64-241 1.6e-17 57.9 In-house 103-288 (302) alignment 
Range on Protein: 64-241
Range on HMM: 103-288/302.0
AFEGFWRMVWEQNSQSIVMLTNLVELGKTKCHKYWPDKTE---TYGGVTVT---LH-QSEIFADYEI---RT--FILSKAKRSGSRMVRQFHFTVWPDKG
. | .| .. . |   .| |...|| .. || .|. || .   ..|  ||.   .. . | |.| .     |  .  .| |.   . |  ..|. |||.|
tlekhwalieqynvaivvqlcsfvedeekkcaeyysdkvggelkfgrytvktvsvktdleeftdkksfklytveiknekkkkkvkktvdilafsawpdhG

VPQYATAVLAFRRKVRALNPRdagpVIVHCSAGVGRTGAYIVIDAMLEQAKKSRTVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVLEAL
 |. | . |   .   .        |.|||||||||||. . |   ..  .| .. |. . .. .|. |   ||...|  ..   |  .|
apkeaytaldilkfcesykkn....vlvhcsaGvGrtGtlvaikyGiqlcskkkvtdllsivlpvrqcryGavqdeqqliylllcvtkgl
subfamily_CG42327_pd Subfamily CG42327 172-236 2.3e-17 57.7 In-house 245-310 (319) alignment 
Range on Protein: 172-236
Range on HMM: 245-310/319.0
RDAGPVIVHCSAGVGRTGAYIVIDAMLEQAKKS-RTVDIRNYLIALRKDRPHMVQTKEQYSFIHSA
 . ||..|||| ||||||  |  |  ... ..| |.||| . .  .|.|| . |.||||| ||.  
esqGPlvvhcsdGvGrtGlviasdiairsleeskrsvdiPqlvssvrrdrasavltkeqyefiykv
subfamily_eak_pd Subfamily eak 8-166 3.8e-17 56.7 In-house 52-207 (332) alignment 
Range on Protein: 8-166
Range on HMM: 52-207/332.0
NKNKNrYANIVAYDHSRVVLERVNGDEDsDYINASFIHgYDGTPRSFIASQGPLPPAFEGFWRMVWEQNSQSIVMLTNLVELGKTKCHKYWPDKT---ET
. |.|   .|| ||.  | |     ...  ||||| .  .    | .| .  .       ||.|| ||.| .||.| . |||.  |  ||.||||     
avnrn.vvkivpydrylvrltssqlnrl.Gyinaslae.fsevGrkyiltGiasedkvfafwqmvleqkspaivqlledvelkleksdkyfpdktreelk

YGGVTVTLHQSEIFADYEIRTFILSKAKRsgSRMVRQFHFTVWPDKGVPQYAtAVLAFRRKV
.| . |.  .    . .| | ..|||     .  |  ...  | .  .|.|    ||.|. .
fGildverkefvkrniletrllelskGne..thrvlhykvfGwtettlpkye.dflalrkvm
subfamily_Sponge-PTP-7_pd Subfamily Sponge-PTP-7 178-244 9e-17 55.2 In-house 2-68 (69) alignment 
Range on Protein: 178-244
Range on HMM: 2-68/69.0
IVHCSAGVGRTGAYIVIDAMLEQAKKSRTVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVLEALTCG
.||||.| ||||..| |   . . |  . ||| | .  .|| || ||  . .| ||| |. |||  |
vvhcssgtgrtgtfiaimvemarikseklvdifnnvqymrkcrpmmvmneieyifihdalvealklG
subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 8-240 1.1e-16 55.3 In-house 47-278 (303) alignment 
Range on Protein: 8-240
Range on HMM: 47-278/303.0
NKNKNRYANIVAYDHSRVVLervngdEDSDYINASFIHgYDgTPRSFIASQGPLPPAFEGFWRMVWEQNSQSIVMLTNLVELGKTKCHKYWPDKTETYGG
| .|||.....  |||.| |       || || ||...  | . .  | .| ||. .   ||.|. ||. . ...|    |  |   .  .| . .    
nmdknrfvdvicldhskvkl......sdssyihasyle.ld.sskkailtqlplshtaadfwqmiieqkvkcvlllltdseydklggdsvfprnqdflkf

----VT-VTLHQSEIFADYEIRTFILSKAkrSGSRMVRQFHFTVWPDKGVPQY-----ATAVLAFRRKVRALnpRDAGPVIVHCSAGVGRTGAYIVID-A
    .    ... |.   . ..   .|.   .   ..   |.  || . .|          .   .  .|     |. | .    .|.||.|.. ... |
eersirvgefkrvelgdgwvlkvlsvsng..dyksflhvhhykawphnsipsdgspkfvkqiwqlqsvlrky..sdstptvymslsgcgragtfalfeta

MLEQAKKSRTVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVLEA
 |   ..  ..|. . |  .|. | | ||   |.|.... . | 
hlslhseqasldlvkclenvrngrlhavqnlsqfsvvytllaeh
subfamily_Sponge-PTP7_pd Subfamily Sponge-PTP7 178-244 1.4e-16 54.6 In-house 1-67 (69) alignment 
Range on Protein: 178-244
Range on HMM: 1-67/69.0
IVHCSAGVGRTGAYIVIDAMLEQAKKSRTVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVLEALTCG
.||||.| ||||..| |   . . |  . ||| | .  .|| || ||  ...| ||| |. |||  |
vvhcssGtGrtGtfiaimvemarikseklvdifnnvqymrkcrpmmvmneneymfihdalvealklG
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 341-429 1.9e-14 47.8 In-house 234-321 (440) alignment 
Range on Protein: 341-429
Range on HMM: 234-321/440.0
ERNAFIATQHPLQHTIEDFWRMVTDYDIGTIVMLNNLHehDQEYPQYLPVEG-ATKYGHIRVSLLSKQEKGDVISTKLKVTRNKKTHEVR
 .||||||| ||. |. ||||.| || | ||.|||.|   |.    | ||.  .  .| . |     ..   |    |..  ... ||.|
kknafiatqmpldstvldfwrlvhdyristiimlnqln..dktcsiywpvntrsvtfgpftvghkgsenmnrvkvrtlelkykeevheir
subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 236-431 3.7e-14 46.9 In-house 34-224 (244) alignment 
Range on Protein: 236-431
Range on HMM: 34-224/244.0
AVLEALTCGNTEIQSENYNQAMQKLASVNRKFQMTGYALEFQRLNSVtSREIPAEEKSVgEKPQNLHKNRFSDIIALNSCRVMLHKEHAdeESDYINAVF
||| | .. |  |.   ....   |.| ...      |   |  ...  |  |.  | .  .|.| .||| .  . ..  || | |        |||| |
avlsanatknryinilpfdetrvilssskkegsdyinanyiqgsqni.irpdpsvmkda.fnpnnswknregaglpfdfnrvplskgsm..gntyinasf

LHVRMERNAFIATQHPLQHTIEDFWRMVTDYDIGTIVMLNNLHEHDQEYPQYLPVEGATKygHIRVSLLSKQEKGDVISTKLKVTRN-KKTHEVRHL
.        .| |||||  |  |||.|. .  .  .|.|  . | |. .|.  |.|   .   | |.|  ..|  .. ...|..  . ...|.   .
vgclgrtaeyiltqhpladtsmdfwkmmlerhvnvlvvlgsveeedeywpdseplewyee..ditvtltdrdefknikasnleiesdmneshqaltm
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 3-48 4.6e-14 46.6 In-house 42-87 (440) alignment 
Range on Protein: 3-48
Range on HMM: 42-87/440.0
ARKPANKNKNRYANIVAYDHSRVVLERVNGDEDSDYINASFIHGYD
|  | || |||| ||.|||||||.|| |.|  ||||||||.| | .
aslpnnkvknryrnilaydhsrvmleevkgvpdsdyinasyingie
subfamily_eak_pd Subfamily eak 278-444 6.7e-14 46.0 In-house 28-197 (332) alignment 
Range on Protein: 278-444
Range on HMM: 28-197/332.0
RLNSVT--SREIPAEEKSVGEKPQNLHKNrFSDIIALNSCRVMLHKEHADeESDYINAVFLHVRMERNAFIATQHPLQHTIEDFWRMVTDYDIGTIVML-
|.| |.   .  ..  .|.... .....|   .|.  .   | |     . .  ||||  .      . .| |  . .  .  ||.|| .    .||.| 
rinivadlddyqrllsisetarleavnrn.vvkivpydrylvrltssqln.rlGyinaslaefsevGrkyiltGiasedkvfafwqmvleqkspaivqll

NNLHEHDQEYPQYLPVEG--ATKYGHIRVSLLSKQEKGDVISTKLKVTRNKKTHEVRHLHHVSWPDKCIPEV
... .. ... .|.| ..    |.|.. |   .  ... .   .|....  .||.| | .   | .  .| .
edvelkleksdkyfpdktreelkfGildverkefvkrniletrllelskGnethrvlhykvfGwtettlpky
subfamily_CG42327_pd Subfamily CG42327 459-531 1.3e-13 45.3 In-house 242-315 (319) alignment 
Range on Protein: 459-531
Range on HMM: 242-315/319.0
QQQCGNAPVLVQCSNGVGRSGTFCAISSVIERLKTE-QVIDVFQVIKRIRANRPGAVESLTQYVFCYQIIQKYL
 ..  . |. | ||.||||.|.  |    |..|..  . .|. |..  .| .|  || .  || | |.....| 
gtresqGPlvvhcsdGvGrtGlviasdiairsleeskrsvdiPqlvssvrrdrasavltkeqyefiykvlseya
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 172-238 2.5e-13 44.5 In-house 260-341 (350) alignment 
Range on Protein: 172-238
Range on HMM: 260-341/350.0
RDAGPVIVHCSAGVGRTGAYIVIDAMLE-------QAKKSRTVDIRN--------YLIALRKDRPHMVQTKEQYSFIHSAVL
  . |..||||||||||| .. .| .|.         |.|| .|  .         .  ||| |  |||...|. ||. |.|
arsspilvhCsaGvGrtGtlvtlDsllsdfeilenltkesrkldvaaktrDlisiivnelrkqrismvqnldqfifiYeall
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 10-116 3.3e-13 43.7 In-house 50-169 (349) alignment 
Range on Protein: 10-116
Range on HMM: 50-169/349.0
NKNRYANIVAYDHSRVVLERVN--------------GDEDSDYINASFIHGYDGTP-RSFIASQGPLPPAFEGFWRMVWEQNSQSIVMLTNLVELGKTKC
 |||| .|. |.||||.|..                .    ||||| ...    .. . .|| | ||| . . |....  .. . .. |..  ||.  ||
aknrykdilPyehsrvklkkslksskvikastsesdsgklddyinanylkltrisvekkyiatqaPlPstvddfykvillngvklvlsLnddkelslekc

HKYWPDKteTYGGVTVTLHQSE
..|| .   .| ..|| |  | 
diywqel..sysnitvklqnss
subfamily_Cele-PTP-5_pd Subfamily Cele-PTP-5 337-531 1.4e-12 40.9 In-house 110-309 (346) alignment 
Range on Protein: 337-531
Range on HMM: 110-309/346.0
HVRMERNAFIAtQHP---LQHTIEDFWRMVTDYDIGTIVML-NNLHEHDQEYPQYLPVEGATKY-GHIRVSLLSKQEKGDVISTKLKVTRNKKTHEV--R
 ...|..  .| | |    .  .|||| |. . .|  . ..  . . ..     .   .|  .| |.. .     .  ||     ..|  . ..  |  .
ifqfehkliva.qlpqmenesfvedfwymiyqeqihlvylmvpddklkntttslfndenggyqytgkmfinnrradvsgdpkeytievlpegnsdsvicq

HLHHVSWPDKCIPEVARSVLDLLDEVQaSQQQCGNAPVLVQCSNGVGRSGTFCAISSVIERLKTEQVIDVFQVIKRIRANRPGAVESLTQYVFCYQIIQK
  ||  |     |  .  .. .. .   |..|  || | |    | ||. .|      |..|      ......| |. .|||.|||..||   | |.  
vhhhapwkhlqqppktlpiikmihqfl.sekqvqnagvcvvslfgcgracsfigalyainqlnngiepniceimknikqqrpggvesfaqyasiyaivfd

YL
|.
yi
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 461-529 2e-12 41.6 In-house 225-293 (297) alignment 
Range on Protein: 461-529
Range on HMM: 225-293/297.0
QCGNAPVLVQCSNGVGRSGTFCAISSVIERLKTEQVIDVFQVIKRIRANRPGAVESLTQYVFCYQIIQK
.  ||..|| || ||||||       ....|. ... ||  ... .| .|.  |..| |. ..|... |
mprnayllvhcsaGvGrsGvvvlsdvilaklrkkripdvaailsilreqrarlvqtleqfellydavlk
subfamily_Sponge-PTP-7_pd Subfamily Sponge-PTP-7 468-526 8e-12 39.4 In-house 2-60 (69) alignment 
Range on Protein: 468-526
Range on HMM: 2-60/69.0
LVQCSNGVGRSGTFCAISSVIERLKTEQVIDVFQVIKRIRANRPGAVESLTQYVFCYQI
.|.|| | ||.||| ||   . |.|.|...|.|  .. .|  ||  |    .|.| .  
vvhcssgtgrtgtfiaimvemarikseklvdifnnvqymrkcrpmmvmneieyifihda
subfamily_Sponge-PTP-4_pd Subfamily Sponge-PTP-4 327-437 2e-11 38.3 In-house 12-122 (130) alignment 
Range on Protein: 327-437
Range on HMM: 12-122/130.0
ESDYINAVFLHVRMERNAFIATQHPLQHTIEDFWRMVTDYDIGTIVMLNNLHEHDQEYPQYLPVEGATKygHIRVSLLSKQEKGDVISTKLKVTRNKKT-
. .|||| |. .    . .. |||||  |  |||.|. .  .  .|.|  . | |. .|.  |.|   .  .| |.|  ..|   . ...|.. .. .  
gntyinasfvGllgrtaeylltqhpladtsmdfwkmmleryvnvlvvlgsveeedeywpdsePlewyee..diivtltdrdefknikasnleiesdlnes

HEVRHLHHVS-WP
|.   . ..| ||
hqaltmfqisnwp
subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 3-151 2.2e-11 37.8 In-house 91-234 (244) alignment 
Range on Protein: 3-151
Range on HMM: 91-234/244.0
ARKPANKNKNRYANIVAYDHSRVVLERvnGDEDSDYINASFIhGYDGTPRSFIASQGPLPPAFEGFWRMVWEQNSQSIVMLTNLVElgktkCHKYWPDKT
| .| |  ||| .  . .| .|| | .  |     ||||||. |  |    .| .| ||  .   ||.|. |.  . .|.|  . |       .||||  
afnpnnswknregaglpfdfnrvplsk..gsmgntyinasfv.gclgrtaeyiltqhpladtsmdfwkmmlerhvnvlvvlgsvee.....edeywpdse

--ETYG-GVTVTLHQSEIFADYEIRTFILSKAKRSGSRMVRQFHFTVWPDKG
  | |   .|||| . . | .     . .        . .  |  . ||  |
plewyeeditvtltdrdefknikasnleiesdmneshqaltmfqisnwpsdg
subfamily_Sponge-PTP7_pd Subfamily Sponge-PTP7 469-526 2.9e-11 37.5 In-house 2-59 (69) alignment 
Range on Protein: 469-526
Range on HMM: 2-59/69.0
VQCSNGVGRSGTFCAISSVIERLKTEQVIDVFQVIKRIRANRPGAVESLTQYVFCYQI
|.|| | ||.||| ||   . |.|.|...|.|  .. .|  ||  |    .|.| .. 
vhcssGtGrtGtfiaimvemarikseklvdifnnvqymrkcrpmmvmneneymfihda
subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 295-374 3e-11 37.4 In-house 32-116 (347) alignment 
Range on Protein: 295-374
Range on HMM: 32-116/347.0
GEKPQNLHKNRFSDIIALNSCRVMLHKEH-----ADEESDYINAVFLHVRMERNAFIATQHPLQHTIEDFWRMVTDYDIGTIVML
 |  ..| |||  |    .. ||.|  |.     ||.   ||||  ..    .. .| ||.|| .|. |||.||.   .  .| .
vewekslsknrskdvklidatrvvlspeksknsraddvetyinashikfdnaskeyiltqyplpdtvrdfwkmvsvtkvtqvvti
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 408-530 4.2e-11 37.2 In-house 200-343 (350) alignment 
Range on Protein: 408-530
Range on HMM: 200-343/350.0
EKGDVISTKLKVTRnkkTHEVRHLHHVSWPDKC---IPEVARSVL----DLLDEVQASQ--QQCGNAPVLVQCSNGVGRSGTFCAISSVIE---RLK---
....... .| ..     ..| .|.   |.|      ||   ..|    ||.|.  | .  ..   .|.|| || |||| ||.... |...    |.   
dnnsltaitlaasd...PyvvyqlqvknWkDlslllnPesilqalevkndliddlfaeshldnarsspilvhCsaGvGrtGtlvtlDsllsdfeilenlt

T--------EQVID-VFQVIKRIRANRPGAVESLTQYVFCYQIIQKY
          .. | ........|  |   | .|.|..|.|. .. |
kesrkldvaaktrDlisiivnelrkqrismvqnldqfifiYeallfy
subfamily_Sponge-PTP-2_pd Subfamily Sponge-PTP-2 7-103 5.1e-11 35.8 In-house 26-89 (169) alignment 
Range on Protein: 7-103
Range on HMM: 26-89/169.0
ANKNKNRYANIVAYDHSRVVLERVNGDEDSDYINAsfihgydgtprsfiasqgplppafegfwRMVWEQNSQSIVMLTNLVElgktkCHKYWPDKTE
.|. ||| |  .|  | || |.||  |  ||||||                            ||.|| |.  ||.| .  .        .||.| .
cnetknrpagplapshtrvklqrvmedlgsdyina............................rmiwetnasvivvlgdtdd.....knnfwpeked
subfamily_Sponge-PTP2_pd Subfamily Sponge-PTP2 7-103 6e-11 35.4 In-house 25-88 (169) alignment 
Range on Protein: 7-103
Range on HMM: 25-88/169.0
ANKNKNRYANIVAYDHSRVVLERVNGDEDSDYINAsfihgydgtprsfiasqgplppafegfwRMVWEQNSQSIVMLTNLVElgktkCHKYWPDKTE
.|. ||| |  .|  | || |.||  |  ||||||                            ||.|| |.  ||.| .  .        .||.| .
cnetknrpagplapshtrvklqrvmedlgsdyina............................rmiwetnasvivvlGdtdd.....knnfwpeked
subfamily_eak_pd Subfamily eak 175-250 1.4e-10 35.1 In-house 238-314 (332) alignment 
Range on Protein: 175-250
Range on HMM: 238-314/332.0
GPvIVHCSAGVGRTGAYIVIDAMLE--QAKKSRTVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVLEALTCGNTEIQS
 | |. .. |  |.|...||| ...  ..||  .  . ....  .. | | | .. |.|||. .||. |   | ... 
ap.iiqsarGsaraGvfvvidllirlidnkkknlysvedlilkvkskrihsvlvalqhsfiyeivldyllrrnnrlrd
subfamily_Sponge-PTP3_pd Subfamily Sponge-PTP3 6-59 4e-10 33.7 In-house 46-95 (95) alignment 
Range on Protein: 6-59
Range on HMM: 46-95/95.0
PANKNKNRYANIVAYDHSRVVLErvnGDEDSDYINASFIHGYDGTpRSFIASQG
 ||  |||. ||. || .||||       ||||||| |. ||      .||.||
eanipknrflnifpydatrvvlt...tkrdsdyinacfvdgyark.ncyiaaqg
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 288-384 4.2e-09 30.2 In-house 36-148 (349) alignment 
Range on Protein: 288-384
Range on HMM: 36-148/349.0
PAEEKSVGEKPQNLHKNRFSDIIALNSCRVMLHKE--------HADEE------SDYINAVFLHV-RME-RNAFIATQHPLQHTIEDFWRMVTDYDIGTI
....  . |  .   |||..||.  .  ||.|.|         ..  |       ||||| .|.. |..  . .|||| ||  |..||.....   .  .
eiddvilseGvelfaknrykdilPyehsrvklkkslksskvikastsesdsgklddyinanylkltrisvekkyiatqaPlPstvddfykvillngvklv

VMLNNLHEHDQEY
. ||. .| . | 
lsLnddkelslek
subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 8-82 5.9e-09 29.9 In-house 37-115 (347) alignment 
Range on Protein: 8-82
Range on HMM: 37-115/347.0
NKNKNRYANIVAYDHSRVVLER-----VNGDEDSDYINASFIHgYDGTPRSFIASQGPLPPAFEGFWRMVWEQNSQSIVM
. .|||  .    | .||||        . |.   ||||| |. .| . . .| .| ||| .   ||.||   .   .| 
slsknrskdvklidatrvvlspeksknsraddvetyinashik.fdnaskeyiltqyplpdtvrdfwkmvsvtkvtqvvt
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 172-239 1e-08 28.9 In-house 263-342 (349) alignment 
Range on Protein: 172-239
Range on HMM: 263-342/349.0
RDAGPVIVHCSAGVGRTGAYIVIDAMLE----QAKKSRTVDIRNY-------LI-ALRKDRPHMVQTKEQYSFIHSAVLE
 .  ...|||||| |||| .. .| .|.      ..|  .....         .  ||| |  |||   |. .|. |.|.
dqlstllvhcsaGcGrtGvlvtldlllsileplqnesnkiklqallkDlisiivnelrkqrismvqnlaqfiaiyealLk
subfamily_Cele-PTP-12_pd Subfamily Cele-PTP-12 8-91 1.4e-08 28.6 In-house 34-115 (332) alignment 
Range on Protein: 8-91
Range on HMM: 34-115/332.0
NKNKNRYANIVAYDHSRVVLERVNGDedSDYINASFIHGYDGTpRSFIASQGPLPPAFEG-FWRMVWEQNSQSIVMLTNLVELGK
| . ||   . ..||||| |   .|    |. |||.. ||     ..| .| |.    |  ||||| |..   |... .. |  |
nmdmnriphlycfdhsrvelapqdgk..ddfynaswvdgyskk.sayifaqapfndhteyvfwrmvserkpsmilvfgdidekqk
subfamily_Cele-PTP-12_pd Subfamily Cele-PTP-12 88-234 2.9e-08 27.6 In-house 144-295 (332) alignment 
Range on Protein: 88-234
Range on HMM: 144-295/332.0
ELGKTKCHKYWPDKTETYGGVTVTLHQSEIFADYEIRTFILSKAKRSGSRMVRQFHFTVWPDK-GVPQYATAVLAFRR--KVRALN--PRDAGPVIVHCS
||    |.|.||.|.      ..... |. ...  ..|| |. ...   .    .||  | |   .|.|   . |  .   .|. .      ||... |.
elkakicrkfwpekrskkdfpalsiqasddhsethmktfnltvtekkqdhqtvlmhfyewadasklpeymldmrasiklqyirsskktgvcigpimlvca

AGVGRTGAYIVIDAMLEQAKKSRTVDIRNYLIALRKDRPHMVQTKEQYSFIH
.|| .   .  || .. .  . . | ... . |.. .|   ..|   ||   
tgvekcaisatidiivsriteehrvgfketmsaikmqrfgcfrtvgpystac
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 52-128 3.4e-08 27.2 In-house 236-311 (440) alignment 
Range on Protein: 52-128
Range on HMM: 236-311/440.0
RSFIASQGPLPPAFEGFWRMVWEQNSQSIVMLTNLVElgkTKCHKYWPDKTE--TYGGVTVTLHQSEIFADYEIRTFIL
 .|||.| ||  .   |||.| . .  .|.|| .| .     |  ||| .|   |.|  ||  . || .    .||. |
nafiatqmpldstvldfwrlvhdyristiimlnqlnd...ktcsiywpvntrsvtfgpftvghkgsenmnrvkvrtlel
subfamily_PTPDC1_pd Subfamily PTPDC1 145-234 5.1e-08 27.5 In-house 88-169 (182) alignment 
Range on Protein: 145-234
Range on HMM: 88-169/182.0
TVWPDKGVPQYATAvLAFRrKVRALNPrDAGPVIVHCSAGVGRTGAyiVIDAMLEQAKKsrtVDIRNYLIALRKDRPHMVQTKEQYSFIH
  |.| ||.   .. |    || |    . | | ||| || ||||   .| ..|  ||.   ..  . .  .|. ||. .||.||  ...
fgwkDygvasleri.Ldiv.kvvafal.qegkvavhChaGlGrtGv..liacylvyakr...ltaekaiklvrskrpksiqtreqvelvk
subfamily_Sponge-PTP3_pd Subfamily Sponge-PTP3 292-349 7.3e-08 26.5 In-house 40-94 (95) alignment 
Range on Protein: 292-349
Range on HMM: 40-94/95.0
KSVGEKPQNLHKNRFSDIIALNSCRVMLHKEhadEESDYINAVFLHVRMERNAFIATQ
 .||    |. |||| .|.  .. ||.|       .||||||.|.     .|..||.|
ytvgsseanipknrflnifpydatrvvlttk...rdsdyinacfvdgyarkncyiaaq
subfamily_Sponge-PTP-4_pd Subfamily Sponge-PTP-4 20-151 1.6e-07 25.7 In-house 5-125 (130) alignment 
Range on Protein: 20-151
Range on HMM: 5-125/130.0
YDHSRVVlervngdeDSDYINASFIhGYDGTPRSFIASQGPLPPAFEGFWRMVWEQNSQSIVMLTNLVElgktkCHKYWPDKT--ETY-GGVTVTLHQSE
.. ||.         . .||||||. |  |  . .. .| ||  .   ||.|. |.    .|.|  . |       .||||    | |   ..||| . .
fevsrlq........gntyinasfv.Gllgrtaeylltqhpladtsmdfwkmmleryvnvlvvlgsvee.....edeywpdsePlewyeediivtltdrd

IFADYEIRTFILSKAKRSGSRMVRQFHFTVWPDKG
 |   .   .  ..      . .  |. . ||  |
efknikasnleiesdlneshqaltmfqisnwpsdg
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 450-531 2.1e-07 24.6 In-house 249-344 (349) alignment 
Range on Protein: 450-531
Range on HMM: 249-344/349.0
DLLDEVQAS--QQQCGNAPVLVQCSNGVGRSGTFCAISSVIER----------LKTEQ-VID-VFQVIKRIRANRPGAVESLTQYVFCYQIIQKYL
||.|.  |    ..   ...|| || | ||.|... . ....           .| ..   | .. ..  .|  |   |. |.|....|. . ||.
dliddlfarlyldtdqlstllvhcsaGcGrtGvlvtldlllsileplqnesnkiklqallkDlisiivnelrkqrismvqnlaqfiaiyealLkyf
0038934 (Phosphotyrosine protein) phosphatases II 142-234 2.6e-07 26.0 In-house 82-170 (194) alignment 
Range on Protein: 142-234
Range on HMM: 82-170/194.0
FHFTVWPDKG-VPQYATAVLAFRRKVRALNPRDAGPVIVHCSAGVGRTGAYIVIdAMLEqakkSRTVDIRNYLIALRKDRPHMVQTKEQYSFIH
..   .||.| ||....    ..   . ||    | | ||| ||.||||  ..  ....    ..  . .  .  .|  ||..... .... ..
ylklpfpddgtvPsleillrfldlvdeflnedpggvvaVHCkaGlgRtGtlvaa.YLiy....rlgmsaeeAialfrekRpgaipnqdyleall
0038934 (Phosphotyrosine protein) phosphatases II 426-529 5.1e-07 25.0 In-house 77-175 (194) alignment 
Range on Protein: 426-529
Range on HMM: 77-175/194.0
HEVRHLHHVSWPDKCIPEVARSVLDLLDEVQASQQQCGNAPVLVQCSNGVGRSGTFCAISsVIERLKTeqviDVFQVIKRIRANRPGAVESLTQYVFCYQ
    . ..  .||.. .     .|. || |.   ... .  |.| |  |.||.||..|    |.||.     .. . |...|  ||||...  ..   ..
kagieylklpfpddgtvPsleillrfldlvdeflnedpggvvaVHCkaGlgRtGtlvaaY.Liyrlgm....saeeAialfrekRpgaipnqdyleallk

IIQK
  . 
ryke
subfamily_DSP23_pd Subfamily DSP23 431-525 2.3e-06 22.3 In-house 54-140 (148) alignment 
Range on Protein: 431-525
Range on HMM: 54-140/148.0
LHHVSWPDKCIPEVArSVLDLLDEVQASQQQcgNAPVLVQCSNGVGRSGTFCAISSVierlkTEQVIDVFQVIKRIRANRPGAVESLTQYVFCYQ
|...  .| . | .   | ...  |. ....  |  | | |  | ||.||. |   |      |. .   . |  .|  |||.||.. |    ..
lvrlriddyhppale.qvvefvrvveeaeek..neavsvhcllgrgrtgtmlacylv.....kerklaaaeaiaevrrlrpgsvetveqeklvrd
subfamily_CDKN3_pd Subfamily CDKN3 431-529 2.5e-06 21.2 In-house 102-194 (202) alignment 
Range on Protein: 431-529
Range on HMM: 102-194/202.0
LHHVSWPDKCIPEVArSVLDLLDEVQASQQQCgnAPVLVQCSNGVGRSGTFCAIssVIerLKTEQVIDVFQVIKRIRANR-PGAVESLTQYVFCYQIIQK
 ||   .|  .|..| | |..|.|.. . ..      || |  |.|||    |   ..  |  ...|.  . |...|  .  .|.... || .  .. .|
vhhypiadglvpdia.sclkileelrinlkay..rktlvhcygglgrsslviac..ll..lylddtiepkdaidklrdlkgsraiqtvkqynylsefrdk
subfamily_Cele-PTP-12_pd Subfamily Cele-PTP-12 299-383 3e-06 20.9 In-house 33-116 (332) alignment 
Range on Protein: 299-383
Range on HMM: 33-116/332.0
QNLHKNRFSDIIALNSCRVMLHKEhaDEESDYINAVFLHVRMERNAFIATQHPLQ-HTIEDFWRMVTDYDIGTIVMLNNLHEHDQE
.|.  ||   . ...  || |  .  | . |. || ..    ...|.| .| |.. ||   |||||..     |... .. |... 
nnmdmnriphlycfdhsrvelapq..dgkddfynaswvdgyskksayifaqapfndhteyvfwrmvserkpsmilvfgdidekqkr