Gene NvecPTP-sf2-3 in Nematostella vectensis

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily NvecPTP-sf2
Protein sequence
ID Type Fasta BLAST phosphatome Note
NvecP046_AA protein Get Run
NvecP046_AA_228-503 phosphatase_domain Get Run
NvecP046_AA_515-796 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_PTPRD_pd Subfamily PTPRD 223-685 1.9e-239 791.0 In-house 2-463 (564) alignment 
Range on Protein: 223-685
Range on HMM: 2-463/564.0
SKPIPIALFPEYVAKMQANGGIRLETEYKKFDNGQQFPWEAARKPANKNKNRYANIVAYDHSRVVLERVNGDEDSDYINASFIHGYDgTPRSFIASQGPL
|||||.| ..|.|||..||.....|.||||...||||.||||.|||||.|||||||||||||||||..|.|||.|||||||||.||. .....||.||||
skpipvaelkehvaklkansdlkfeeeykkieegqqftweaankpaNkaKNRyanivaYdhsRVvLskvegdegsDYINAsfidgyr.krkayIAtqgPl

PPAFEDFWRMVWEQNSQSIVMLTNLVELGKTKCHKYWPDK-TETYGGVTVTLHQSEIFAEYEIRTFILSKAKQSGSRMVRQFHFTVWPDKGVPQYATAVL
....||||||||||||..|||||.|.| ||.|||||||.| |||||..||||...| .|.||||||.|.|.|.| ||.||||||| |||.|||..||..|
aetiedFWRmvweqnsstiVmltkleEkgkvkchkYWPekgtetygeltVtleeeeeladyeirtfklkkkkssesreVrqFhFtsWPdhgvpesatslL

AFRRKVRALNPRDAGPVIVHCSAGVGRTGAYIVIDAMLEQAKKSRTVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVLEALTCGNTEIQSENCNQAMQKL
...|||||||..||||..|||||||||||..||||||||..|...||||..|..||||.|..||||.|||.|||.|.||||.|||||..|||..|..|||
dlirkvralnepdagPivVhCSaGVGRTGtfividamlerikeektvDiyqyvkalrkqRnamVqteeQYiFiheailealacgntevesenlkqhlqkL

ASVNRKFQMTGYALEFQRLNsvTSREIPAEEKSVGEEPQNLHKNRFSDIIALNSCRVMLHKEHADEESDYINAVFLHAHRGRNAFIATQHPLLETVEDFW
|.|.....|||..||||||.  |..||..||..|...|.|..|||||.|.||.||||.|....|.||||||||..|.|.|...||||||.|| .||||||
aeveedtemtgleleFqrLa..takeieleefavatkpknkkknrfsnilalescrvvlsairakeesdyinasyleayrekrafiatqaplkntvedfw

RMVTDYDIGTIVMLNNLHE-LDQEYPKYWPDHGPTKYGHIGVSVLSKQEQGDVICTKLKVTRKKV
|||.......||||..|.| |..|. .|..|.. ||||.|...||.|.|..|....| ||..|. 
rmvweeevkiivmltkleekleeesseyysdleatkyGeitikvlkkkeksdilfrkkkvevkek
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 505-802 1.3e-147 485.8 In-house 1-297 (298) alignment 
Range on Protein: 505-802
Range on HMM: 1-297/298.0
GNTEIQSENCNQAMQKLASVNRKFQMTGYALEFQRLNSVTSrEIPAEEKSVGEEPQNLHKNRFSDIIALNSCRVMLHKEHADEESDYINAVFLHAHRGRN
|||||..|....|.||||.|..|...|||||||||||||.| ||..|||.|...|.| .|||..|||||.|.||.|.||.||||||||||.||||..|||
gnteieaedlkaalqklaavkkkkkltgyalefqrlnsvss.eieeeekevarkpenkkkNRyadiialdssRvvLekedadeesdYiNAsflhaykgrn

AFIATQHPLLETVEDFWRMVTDYDIGTIVMLNNLHELDQ-EYPKYWPDHGPTKYGHIGVSVLSKQEQGDVICTKLKVTRKKVRrKTHEVRHLHHVSWPDK
||||||.|| |||||||||||..||||||||.||.|||. .|.|||||.| ..||.| ||.|||.|..|.|..||||..||.. |..|||.||..|||||
afiatqaPltetvedFWrmvteedigtiVmltnleeldktkyhkywPdegketygeitvsllskeefadlivrklkvskkkee.kerevrqlhftsWpdk

CIPEVACSVLDLLDEAQTSQQQCGNAPVLVQCSNGVGRSGTFCAISSVLERLKTEQVIDVFQVIKRIRVNLPGAVESPTQYMFCYQIIQKYLDSFSDYA
..||.|.||||||.. ..||||.||.||.||||.||||||||.||.|||||.|.|||.|||||.|..|.. ||||.. .||.|.|......||||.|..
gvpenatsvldllrkvrasqqqagnkpvivqCsaGvgRsGtfiaidsvlervkkeqvvDvfqvvkvlRkkrpgavqteeqYvfiyeavlealdsfndei
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 220-510 1.6e-137 452.7 In-house 3-298 (298) alignment 
Range on Protein: 220-510
Range on HMM: 3-298/298.0
DDLSKPIPIALFPEYVAKMQANGGIRLETEYKKFDNGQQ----FPWEAARKPANKNKNRYANIVAYDHSRVVLERVNGDEDSDYINASFIHGYDGTPrSF
....... .|......|...... .....|.........    . .|.||||.||.|||||.|.|.|.||||||....||.||||||||.|.|.|.. .|
teieaedlkaalqklaavkkkkkltgyalefqrlnsvsseieeeekevarkpenkkkNRyadiialdssRvvLekedadeesdYiNAsflhaykgrn.af

IASQGPLPPAFEDFWRMVWEQNSQSIVMLTNLVELGKTKCHKYWPD-KTETYGGVTVTLHQSEIFAEYEIRTFILSKAKQSGSRMVRQFHFTVWPDKGVP
||.|.||....|||||||.|.....|||||||.||.|||.|||||| ..|||| .||.|...| ||....|....||.|....|.|||.|||.|||||||
iatqaPltetvedFWrmvteedigtiVmltnleeldktkyhkywPdegketygeitvsllskeefadlivrklkvskkkeekerevrqlhftsWpdkgvp

QYATAVLAFRRKVRAlNPRDAG--PVIVHCSAGVGRTGAYIVIDAMLEQAKKSRTVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVLEALTCGNTEIQ
..||.||...||||| ....||  ||||.|||||||.|..|.||..||..||...||.......|||.||..|||.|||.||..||||||...|.||.
enatsvldllrkvra.sqqqagnkpvivqCsaGvgRsGtfiaidsvlervkkeqvvDvfqvvkvlRkkrpgavqteeqYvfiyeavlealdsfndeie
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 263-505 7.4e-125 410.2 In-house 3-245 (250) alignment 
Range on Protein: 263-505
Range on HMM: 3-245/250.0
AARKPANKNKNRYANIVAYDHSRVVLERVNGDEDSDYINASFIHGYDGTpRSFIASQGPLPPAFEDFWRMVWEQNSQSIVMLTNLVELGKTkCHKYWP-D
 |.||.||.|||||.|.|.|.||||||...||..||||||||.||||.. ..|||.||||....|||||||.|..|..|||||||.| .|| .|.||| .
vakkpqnkeknryadiialdssrvvLekekgdkesdyinasflhgyder.kafiatqgPlqatiedfWrmvleeksgtivmLtnLkesekt.yhqywPve

KTETYGGVTVTLHQSEIFAEYEIRTFILSKAKQSGSRMVRQFHFTVWPDKGVPQYATAVLAFRRKVRALNPR-DAGPVIVHCSAGVGRTGAYIVIDAMLE
|.|.||.|||.|...|.||.|..|...|||||....|.|||.||.||||||||..|||||....||.| ... ...||||.|||||||.||.|.|||.||
kaekyGdvtvsllskeefadytkrklklskakkaderivrqlhfvvWPdkgvPevatavLellkkvqasqqqagnaPvivqCsaGvgrsGafiaidavle

QAKKSRTVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVLEALTCG
..||...||.......|||||||.|...|||.|.....|.||.. 
rlkkekvvdvfkvikvlrkdrphavesleqyvfvyeiilkaldsv
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 553-803 8.5e-124 406.7 In-house 1-250 (250) alignment 
Range on Protein: 553-803
Range on HMM: 1-250/250.0
KSVGEEPQNLHKNRFSDIIALNSCRVMLHKEHADEESDYINAVFLHAHRGRNAFIATQHPLLETVEDFWRMVTDYDIGTIVMLNNLHELDQEYPKYWPDH
|||...|||..|||..|||||.|.||.|.||..|.|||||||.|||....|.||||||.|| .|.|||||||.....||||||.||.| ...|..|||  
ksvakkpqnkeknryadiialdssrvvLekekgdkesdyinasflhgyderkafiatqgPlqatiedfWrmvleeksgtivmLtnLkesektyhqywPve

GPTKYGHIGVSVLSKQEQGDVICTKLKVTRKKvRRKTHEVRHLHHVSWPDKCIPEVACSVLDLLDEAQTSQQQCGNAPVLVQCSNGVGRSGTFCAISSVL
...|||.. ||.|||.| .|.. .|||....| . .   ||.||.|.||||..|||| .||.||.. |.||||.|||||.||||.||||||.|.||..||
kaekyGdvtvsllskeefadytkrklklskak.kaderivrqlhfvvWPdkgvPevatavLellkkvqasqqqagnaPvivqCsaGvgrsGafiaidavl

ERLKTEQVIDVFQVIKRIRVNLPGAVESPTQYMFCYQIIQKYLDSFSDYAN
||||.|.|.|||.|||..| . |.|||| .||.|.|.||.|.|||..|||.
erlkkekvvdvfkvikvlrkdrphavesleqyvfvyeiilkaldsvedyar
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 226-540 1.9e-116 383.6 In-house 2-318 (318) alignment 
Range on Protein: 226-540
Range on HMM: 2-318/318.0
IPIALFPEYVAKMQANGGIRLETEYKKF-DNGQQFPWEAARKPANKNKNRYANIVAYDHSRVVLERVNGDEDSDYINASFIHGYDgTPRSFIASQGPLPP
|..  . . |......| . |..||...  . ... .  . .|.||.|||||||.||||.|| |. ..|.|.||||||..| ||    ...||.|.||| 
isvedleshvrrlresGelllseeyerlsrseetvtslkslepvnkaknryanilaydhtrvkLqmlegeegsDyinanyidGyr.rkkayiaaqaPlpe

AFEDFWRMVWEQNSQSIVMLTNLVELGKTKCHKYWPDK-TETYGGVTVTLHQSEIFAEYEIRTFILSKAKQSGSRMVRQFHFTVWPDKGVPQYATAVLAF
..||||||||||||. |||||...| ||.|.|.|||.| ...|| ..|.|...  ...| .|.| ... ... ||.|||.|.| |||.|||. .. .|..
tieDfWrmvWeqnsavivmltqeeergkakvhryWPskgsrsygklvvelkeevelsdyvlrefkvtrteeeesrqvrqyhytsWpdegvpesgaslldl

RRKVRALN-PRDAGPVIVHCSAGVGRTGAYIVIDAMLEQAKKSRTVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVLEALTCGNTEIQSENCNQAMQKLA
 |.|.. . . .|||..||||||||||| .|..|..||..|.  .||. ..   ||. |. ||||..|| ||. ..||||..|.||..... .. ...| 
vrqvskaqqksgagpivvhCsaGvGrtGvfiavdillerikaealvDvfqtvkqlreqrnlmvqtedqyefiydvllealasgdtevdasdlrsrirelr

SVNRKFQMTGYALEFQRL
 .. .  .|   .|||||
eqdpesgttemdaefqrl
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 224-538 2.5e-109 360.2 In-house 3-319 (319) alignment 
Range on Protein: 224-538
Range on HMM: 3-319/319.0
KPIPIALFPEYVAKMQANGGIRLETEYKKFDNGQQFPWEAARKPANKNKNRYANIVAYDHSRVVLERVNGDEDSDYINASFIHGYDGTpRSFIASQGPLP
..|... . |.. .....|   || |.|........ .. | |. ||.|||| ||.|||..||||  ..| |.||||||||| ||.   . ||| |.|| 
teievqeLkerlkalastgetllekefkllkeavndtfdsaskeenkkknryqnilaydrtrvvlseldgvegsdyinasfidgyqer.ekfiatqaPle

PAFEDFWRMVWEQNSQSIVMLTNLVELGKTKCHKYWPDKT-ETYGGVTVTLHQSEIFAEYEIRTFILSKAKQSG-SRMVRQFHFTVWPDKGVPQYATAVL
 ..|||||||||..|  .||||.||| .| |..||||... |.|| ..||| . |  ..|.|| . | |...   .|.| .|..| |||..||..||..|
ntiedfWrmvWeeessivvmltklveklkvklkkywpeenfeeyGrlivtleeeeeledyiirklklnkkssevetRevkhfqyteWpdhdvPekatsll

AFRRKVRALNPR-DAGPVIVHCSAGVGRTGAYIVIDAMLEQAKKSRTVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVLEALTCGNTEIQSENCNQAMQK
.. ...|    . ..||..|||||||||||..||.|||||. |.  ..|. ..   ||  |. |||..|||.||. |.|||...|.|||. .. .. ...
dllkrirksrektqsgPivvhCsaGvGRtGtfivldamlervkeegvlDvfstvsrlRtqRnimvqrpeqYkfiyealleaveagdteievqdlrdrlkq

LASVNRKFQMTGYALEFQ
||. . .  .|| . |||
laekvadtgetglerefq
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 262-500 9.9e-105 344.0 In-house 1-239 (239) alignment 
Range on Protein: 262-500
Range on HMM: 1-239/239.0
EAARKPANKNKNRYANIVAYDHSRVVLERVNGDEDSDYINASFIHGYDGTPRSFIASQGPLPPAFEDFWRMVWEQNSQSIVMLTNLVELGKTKCHKYWPD
|||.|  || ||||||||.|||||||||... |  |||||||... |||.|...||.|| . ..  |||||.|..    ||||| |.|  | |||.||||
eaakkrvnkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpd

KTETYGGVTVTLHQSEIFAEYEIRTFILSKAKQSGSRMVRQFHFTVWPDKGVPQYATAVLAFRRKVRALNPRDAGPVIVHCSAGVGRTGAYIVIDAMLEQ
 |  |  . |||...|.||.| ||||..|.  |.  | | |.|||||||||||||||||| .|||.   .   | | ..|||||||||||..|||||| |
stskycnlrvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcsagvgrtgaflvidamlrq

AKKSRTVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVLE
||| .|||| ||. |.|.|||||||| ||| ||| ||||
akkqktvdifnyvkairedrphmvqtseqyvfihlavle
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 263-501 1e-104 343.9 In-house 1-239 (239) alignment 
Range on Protein: 263-501
Range on HMM: 1-239/239.0
AARKPANKNKNRYANIVAYDHSRVVLERVNGDEDSDYINASFIHGYDGTPRSFIASQGPLPPAFEDFWRMVWEQNSQSIVMLTNLVELGKTKCHKYWPDK
||.|  || ||||||||.|||||||||... |  |||||||... |||.|...||.|| . ..  |||||.|..    ||||| |.|  | |||.|||| 
aakkrvnkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpds

TETYGGVTVTLHQSEIFAEYEIRTFILSKAKQSGSRMVRQFHFTVWPDKGVPQYATAVLAFRRKVRALNPRDAGPVIVHCSAGVGRTGAYIVIDAMLEQA
|  |  . |||...|.||.| ||||..|.  |.  | | |.|||||||||||||||||| .|||.   .   | | ..|||||||||||..|||||| ||
tskycnlrvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcsagvgrtgaflvidamlrqa

KKSRTVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVLEA
|| .|||| ||. |.|.|||||||| ||| ||| |||||
kkqktvdifnyvkairedrphmvqtseqyvfihlavlea
subfamily_PTPRG_pd Subfamily PTPRG 226-517 1.2e-103 342.3 In-house 1-302 (563) alignment 
Range on Protein: 226-517
Range on HMM: 1-302/563.0
IPIALFPEYVAKMQANGGIRLETEYK---KFDNGQQFPWEAARKPANKNKNRYANIVAYDHSRVVLERVNGDEDS-DYINASFIHGYDgTPRSFIASQGP
.|.  | ..||.. |.| |... |..   .  . .... |...|| ||.|||| ||||||.||| |. . | ... |||||..|.||    . |||.|||
vpvkefakhvaslhadgdigfseefealqsetiskdldaehsqkpenkrKnRylnivaydrsRvklsplpgkkkklDYinAnyidGyq.kskafiatqgp

LPPAFEDFWRMVWEQNSQSIVMLTNLVELGKTKCHKYWP-DKTETYGGVTVTLHQSEIFAEYEIRTFILSK-----AKQ-SGSRMVRQFHFTVWPDKGVP
|.  |.|||||.||||.. |||.||||| |. ||. ||| |..|||| ..||| ..|..| | .||... .      ||    ..|||.|.| |||.|||
lkdtfddFWrmiWeqnvaiivmitnlvergrrkcdvYWPkdesetygalqvtlieeevlalytvrtlviknlklkkkkqcdteklvrqyhytkWPdhgvP

QYATAVLAFRRKVRALNPRDAGPVIVHCSAGVGRTGAYIVIDAMLEQAKKSRTVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVLEALTCGNTEIQSENC
.... || | .|  | |...|||..||||||||||| |||.|..|.| ..  .|.. . |  .|  |...|||.||| |.| |.|||.. ..||...|. 
ehslpvLifvkkssaankaeaGPivvHcsaGvgrtGtyivldtllkqiqqenavnvfgflkhiraqRnflvqteEqYiflhdalleaiasketellaeqv

NQA
.. 
eel
subfamily_PTPRB_pd Subfamily PTPRB 223-504 3.3e-102 336.5 In-house 4-287 (293) alignment 
Range on Protein: 223-504
Range on HMM: 4-287/293.0
SKPIPIALFPEYVAKMQANGGIRLETEYKKFDN-GQQFPWEAARKPANKNKNRYANIVAYDHSRVVLERVNGDEDSDYINASFIHGYDgTPRSFIASQGP
|||| .  | |.|.||.|.  .|.  ||... . |..   .||....|..|||| ||..|||||| |. ......||||||..|.||  .|| |||.|||
skpiklekfeehvkkmkadsdlrfseeyeelkavgkdqavkaaelavnraknrytnilpydhsrvkLaalkdesgsDYinanyipgyn.sprefiatqGP

LPPAFEDFWRMVWEQNSQSIVMLTNLVELGKTKCHKYWPDK--TETYGGVTVTLHQSEIFAEYEIRTFILSKakQSGSRMVRQFHFTVWPDKGVPQYATA
|| ...||||||||..|. |||||.||| ||.||..|||..  . .|| ..||| ..|   .. ||.. ..|  .. .| |||.||| ||| |||. ...
lpetvddfWrmvwekkssiivmltqlvekgkvkCeeYWPadeepvlyGdikvtlvaeeeledwvirelkiek..ekeerkvrqyhftsWpdhgvPektkt

VLAFRRKVRALN--PRDAGPVIVHCSAGVGRTGAYIVIDAMLEQAKKSRTVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVLEALTC
.|.| |.||       ...|..|||||||||||..| .| .|.. ... .|||   ...||..| ..|||..|| |||..||. |. 
lldfvrtvreaiektaskrPivvhCsaGvGRtGtfialdrllqaieeedyvdifgivaelReeRnllvqtekqYifihqcvldllrk
subfamily_PTPRK_pd Subfamily PTPRK 235-518 3.9e-100 329.7 In-house 13-293 (314) alignment 
Range on Protein: 235-518
Range on HMM: 13-293/314.0
VAKMQANGGIRLETEYKKFDNGqqfpWEAARKPANKNKNRYANIVAYDHSRVVLERVNGDEDSDYINASFIHGYDgTPRSFIASQGPLPPAFEDFWRMVW
.|..... |  .  ||. . .|    |.||.|  |..|||. .|.|||.|||.|  ..|| .||||||..| .|   |. ||. ||||.   .||||.|.
iallkraegygfkeeyeslfeg....wdaakkdenreknrsgdilaydrsrvflitidgdpssdyinaalidsyk.rpaafivtqgPlqetvkdfWrlvy

EQNSQSIVMLTNLVELGKTKCHKYWPDKTETYGGVTVTLHQSEIFAEYEIRTFILSK--AKQSGSRMVRQFHFTVWPDKGVPQYATAVLAFRRKVRALNP
..|. ||||||.||| |. || ||||..||.|| . |.| ..|. ||. .|.| ..|   .|.. |.||||.|. ||| .||..||..|.. |.| . ..
dencasivmltelvevgrvkClkyWPedtevygdikvelvetellaelvvrifrveklargqeeirevrqfqflgWpdhdvPvsatgllklvrrvkksqe

RDAGPVIVHCSAGVGRTGAYIVIDAMLEQAKKSRTVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVLEALTCGNTEIQSENCNQAM
 .||...|||||| ||||..|.|| .|. ... ..||. |   .||. .. ||.|.||| ||. ..|||  ||.| |   . . . 
eeaGrivvhCsaGaGrtGtfiaidivldmieregvvdvfnavktlrsrkvnmveteeqykfiydvileaclcgetaipvsefkaly
0040438 (Phosphotyrosine protein) phosphatases II 231-523 6.5e-100 329.7 In-house 5-297 (317) alignment 
Range on Protein: 231-523
Range on HMM: 5-297/317.0
FPEYVAKMQANGGIRLETEYKKFDNGQQFPWEAARKPANKNKNRYANIVAYDHSRVVLERVNGDEDSDYINASFIHGYDGTPRsFIASQGPLPPAFEDFW
..... .. ...  .|. |...... .  ... |..|.||.|||| .|. ||||||.|  ..||.||||||||...|.. ... ||| |||||  .||||
lllalldllksdftalleefedllslkldtysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyvdgpnlkrk.fIatqgPlpntvedFw

RMVWEQNSQSIVMLTNLVELGKTKCHKYWP-DKTETYGGVTVTLHQSEIFAEYEIRTFILSKAKQSGSRMVRQFHFTVWPDKGVPQYATAVLAFRRKVRA
||||||....|||||.|.|||. ||..||| ..| |||..|||| . |  |....||. ... . | ||.|..||.| ||| |||.. . .|.| ..||.
rmvweqgvtvivmLteleelgrekcaqYwplgetltygdftvtllseeelagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfleavre

LNPRDAGPVIVHCSAGVGRTGAYIVIDAMLEQAKKSRTVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVLEALTCGNTEIQSENCNQAMQKLAS
 .... |||.|||||||||||..|... |||| .| ..||. . .  ||. ||..||| ||| |.. |.|| |....| .   .   ...||  
aledpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalleylkrkltlepaselklkllklli
0051299 (Phosphotyrosine protein) phosphatases II 224-502 1.1e-99 328.8 In-house 3-286 (288) alignment 
Range on Protein: 224-502
Range on HMM: 3-286/288.0
KPIPIALFPEYVAKMQANGGIRLETEYKKFDNGQ-QFPWEAARKPANKNKNRYANIVAYDHSRVVLERVNGDEDSDYINASFIHGYDGTPRsFIASQGPL
..|..  . ..| |..|||  .|. |.... . . .... ||..|.|..|||| .|..||||||.|  ..|.|.|||||||.|.||. . . ||| ||||
teisveellklvlkllangltglleefeellsllpdltlsaallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyidgynlkrk.fIatqgPl

PPAFEDFWRMVWEQNSQSIVMLTNLVELGKTKCHKYWP-DKTETYGGVTVTLHQSEIFAEYEIRTFILSKA----KQSGSRMVRQFHFTVWPDKGVPQYA
|  .|||||||||||.. |||||.|||||..||..||| ....||| .||||   |....| .||.....     ... ||.|..||.| ||| |||...
pntvedFWrmvweqnvrvIvmltklvelgrekcaqYwplggsltygditvtllseevlddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpdsp

TAVLAFRRKVRALNPRDAGPVIVHCSAGVGRTGAYIVIDAMLEQAKKSRTVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVLEAL
...|.| |.||  .. . |||.|||||||||||..|..| .||| .| ..||. ...  ||. ||.|||| ||| |.. |.||.|
ellldflrlvrkalasgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtpeqyrfvyealleyl
0050432 (Phosphotyrosine protein) phosphatases II 220-506 2.6e-99 327.7 In-house 20-303 (308) alignment 
Range on Protein: 220-506
Range on HMM: 20-303/308.0
DDLSKPIPIALFPEYVAKmqANGGIRLETEYKKFDNGQQ-FPWEAARKPANKNKNRYANIVAYDHSRVVLervngDEDSDYINASFIHGYD-GTPRSFIA
   |.....  . ... |  |..  .||.|.... . .  .....|..|.||.|||| .|..||||||.|     ||.|||||||...||. . || |||
lvsslklsvldllkllek..aldlglleeefeellsvkplleysvallpenkdkNrykdilpydhsRVkl.....degsdYInAsyvdgyssklprkfIa

SQGPLPPAFEDFWRMVWEQNSQSIVMLTNLVELGKTKCHKYWPD----KTETYGGVTVTLHQSEIFAEYEIRTFILSKAKQSGSRMVRQFHFTVWPDKGV
 |||||  .|||||||||||.. |||||.||| |. ||..|||.    ....||..||||   |....| .||..|.. . . ||.|..||.| ||| ||
tqgPlpntvedFwrmvweqnvrvIvmLtklvengrekcaqYwplelgggsleygkftvtllseevlddytvrtleltnlgdgesrtvthfhytnWpdhgv

PQYATAVLAFRRKVRALNprDAGPVIVHCSAGVGRTGAYIVIDAMLEQAKKSRTVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVLEALTCGN
|......|.| ..||  .  . ||..|||||||||||..|..| .||| .| ..||. ...  ||. ||.||||.||| |.. |.|| | .  
Ppspeilldflelvrksl..pggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtpeqylflyralleylklkl
subfamily_PTPRA_pd Subfamily PTPRA 224-536 3.3e-98 323.6 In-house 12-329 (330) alignment 
Range on Protein: 224-536
Range on HMM: 12-329/330.0
KPIPIALFPEYVAKMQANGGIRLETEYKKFDN-GQQFPWEAARKPANKNKNRYANIVAYDHSRVVLERVNGDEDSDYINASFIHGYDGTpRSFIASQGPL
 |.|.  . | . . .|.   ..  |.. .     |   |.| |  ||.|||. ||. ||.|||.|  ..| |.|||||||||.||     .|||.|||.
fplpvekleeeirirsaddnklfreefnalPagpiqatlelaskeenkeknrvvnilPydfsrvilsvkeGveesdyinasfidGykek.dkfiaaqGPk

PPAFEDFWRMVWEQNSQSIVMLTNLVELGKTKCHKYWPDK-TETYGGVTVTLHQSEIFAEYEIRTFILS----KAKQSGSRMVRQFHFTVWPDKGVPQYA
  . ||||||.|||.|..|||||.| |  ..||..||||. . ||| ..|.......  .| .| |..     ....  ||.||||||| ||| |||  .
eetvedfwrmiweqksativmltelkerkeekcaqywPdeGlvtyGnirvevedetvlvdytvrkflvqqlpdatrekksrlvrqfhftswPdvGvPfep

TAVLAFRRKVRALNPRDAGPVIVHCSAGVGRTGAYIVIDAMLEQAKKSRTVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVLEALTCGNTEIQSENCNQA
  .| . .||..||.. |||..|||||||||||..||.||.||. |  | ||. . .  ||. ||.||||.||| ||. ..||    |.||..    .. 
iGmlkllkkvkklnqqsagpivvhcsaGvGrtGtfivldavlervkaerkvdvfefvkrlrlqrpqmvqtdeqyefiykvlleyylygdteldvsslekh

MQKLASVNRKFQMTGYALE
.||| .   ... .|   |
lqklynkitgtdkigleee
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 224-514 1.3e-96 318.3 In-house 4-291 (315) alignment 
Range on Protein: 224-514
Range on HMM: 4-291/315.0
KPIPIALFPEYVAKMQANGGIRLETEYKKFDNGQQFPWEAARKPANKNKNRYANIVAYDHSRVVLERVNGDEDSDYINASFIHGYDgTPRSFIASQGPLP
.|||.  .  |||. .|.    .. .|.    || .| . |.|  ||.|||| ||.|||.||| |  .. |..|||.||.|| ||.  .| .||.|||..
qpipldqlityvaqkkastkngfkqdyesipggqlhpldvakkienkqknryiniiaydksrvqlpllendphsdyvnanfidGyn.kkrryiaaqgpnv

PAFEDFWRMVWEQNSQSIVMLTNLVELGKTKCHKYWPDKTETYGGVTVTLHQSEIFAEYEIRTFilSKAKQSGSRMVRQFHFTVWPDKGVPQYATAVLAF
 . .||||.|.|..   |||||||||  | |. ||||||  .|| .|||. . |.. || .||.  |   ..  | | |.|.| ||| |||.|..... .
asvkdfwrlvfeedigkivmltnlvegekrkaekywpdkkviyGkitvtrkseevnteytvrtl..svvfgdnirevvqlhytswpdmgvpkytiplmnl

RRKVRALNPRDAGPVIVHCSAGVGRTGAYIVIDAMLEQAKKSRTVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVLEALTCGNTEIQSENC
 |.|.  .  ..|...|||||||||||..| .||.|.||.  . .|. |..  .|. | .|||. ||| ||..|.||.. ||.| |  .  
irtvkqhhtnsvgaivvhcsaGvGrtGtfitldavldqaeaenaidvynfitgvrqnrikmvqvaeqyqfiydalletfvcgdtsiaqdly
0046845 (Phosphotyrosine protein) phosphatases II 246-507 6.1e-95 313.1 In-house 2-279 (284) alignment 
Range on Protein: 246-507
Range on HMM: 2-279/284.0
LETEYKKFDNGQQF---PWEAARKPANKNKNRYANIVAYDHSRVVLERVNGD-EDSDYINASFIHGYD----GTPRSFIASQGPLPPAFEDFWRMVWEQN
|| |...  . . .   ....|..|.|..|||| .|..||||||.| ...|| |||||||||...|||     ... ||| |||||  .|||||||||||
leeefeellsltvklllslsvallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweqn

SQSIVMLTNLVELGKTKCHKYWPDK--TETYGGVTVTLHQSEIFAEYEIRTFILSKAK-QSGSRMVRQFHFTVWPDKGVPQYATAVLAFRRKVRALNP--
.. |||||.||| |..||..|||..  . |||..||||   |..  | .||. |.. .  . ||.|..||.| ||| |||.... .|.| |.|| |..  
vrvIVmltelvengrekcaqYwplegevltygdftvtllseevkddytvrtleltnlgytgesrtvthfhytswpdhgvppspedlleflrlvrellenl

RDAGPVIVHCSAGVGRTGAYIVIDAMLEQAKKSR---TVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVLEALTCGNT
 . ||..|||||||||||..|..| .||| .| .   .||. ...  ||. ||.|||| ||| |.. |.||.| ...|
pgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyealleylklklt
0043336 (Phosphotyrosine protein) phosphatases II 226-500 4.8e-94 310.2 In-house 2-275 (278) alignment 
Range on Protein: 226-500
Range on HMM: 2-275/278.0
IPIALFPEYVAKMQANGGIRLETEYKKFDNGQQFPWEAARKPANKNKNRYANIVAYDHSRVVLERVNGDEDSDYINASFIHGYDGTPRsFIASQGPLPPA
|..  ........ .|.  .|. |...... . .... |..|.||.|||| .|..||||||.|. ..||.||||||||.. ||. ... |||.|||||  
isvkdllkallelllnlktllllefeellsfkldtysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyvdgynvprk.fiatqgPlpet

FEDFWRMVWEQNSQSIVMLTNLVELGKTKCHKYWPDKTETYGGVTVTLHQSEIFAEYEIRTFILSKAKQSGSRMVRQFHFTVWPDKGVPQYATAVLAFRR
.|||||||||.....|||||.|||||..||..|||....|||..||||   | .. | .||. ... . . ||.|...|.. ||| |||   . .| | .
vedFwrmvwelgvttivmLtelvelgrvkcaqYwpggsltygdftvtllkeehlddytvrtlevtnlgdgesrtvthyhylgwpdhgvpeslsllldflk

KVRALNPRDAGPVIVHCSAGVGRTGAYIVIDAMLEQAKKSRTVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVLE
.||  .. . |||.|||||||||||..|... .|||..| ..||. . .  ||. ||..||| .|| |.. |.||
avrealedsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflyealle
0039614 (Phosphotyrosine protein) phosphatases II 225-506 5.6e-94 310.2 In-house 13-293 (297) alignment 
Range on Protein: 225-506
Range on HMM: 13-293/297.0
PIPIALFPEYVAKMQANGGIRLETEYKKFDNGQQfPWEAARKPANKNKNRYANIVAYDHSRVVLERVNG-DEDSDYINASFIHGYDGTPRSFIASQGPLP
|||.  .. .. ...||.  .|..|...  . .  ... |..|.||.|||| .|..||||||.|  ..| |.||||||||.. ||| ..| |||.|||||
piplsvldlllllekansktllllefeellslkp.dysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfIatqgPlp

PAFEDFWRMVWEQNSQSIVMLTNLVELGKtKCHKYWPDKTETYGGVTVTLHQSEIFAEYEIRTFILSKakQSGSRMVRQFHFTVWPDKGVPQYATAVLAF
  .||||||||||....|||||.|||||. ||..|||....|||..|||| . |  . | .||. ...   . ||.|..|..| ||| |||.... .| |
etvedFwrmvweqgvtvivmLtklvelgr.kcaqywpeeggtygdftvtllkvehldgytvrtlevtn..ngesrtvthfqytgwpdhgvppslelllef

RRKVRALNPR--DAGPVIVHCSAGVGRTGAYIVIDAMLEQAKKSRTVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVLEALTCGN
 ..||  . .  . |||.|||||||||||..|... |||| .| ..||. . .  ||. ||..||| .|| |.. |.|| | ...
lelvrealaelpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydallellkrkl
0036941 (Phosphotyrosine protein) phosphatases II 239-509 2.2e-93 308.1 In-house 8-284 (297) alignment 
Range on Protein: 239-509
Range on HMM: 8-284/297.0
QANGGIRLETEYKKFDNGQ-QFPWEAARKPANKNKNRYANIVAYDHSRVVLervnGDEDSDYINASFIHGYDGTPRsFIASQGPLPPAFEDFWRMVWEQN
....  .|..|...... . ......|..|.|..|||| .|..|||.||.|    .||.|||||||.. ||| . . ||| |||||  .|||||||||||
kllflalllkefeellpllllgslsvallpenleknRykdilpydhtRVkl....ddegsdYinAsyvdgydlkrk.fIatqgPlpntvedFWrmvweqn

SQSIVMLTNLVELGKTKCHKYWP---DKTETYGGVTVTLHQSEI--FAEYEIRTFILSKAKQSGSRMVRQFHFTVWPDKGVPQYATAVLAFRRKVRALNP
...|||||.|||||. ||..|||   ... |||..||||   |.  ...| .||. ... . . ||.|..||.| ||| |||.... .|.| ..||  ..
vtvIvmltelvelgrekcaqywpleegesltygdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfielvrkvlk

R--DAGPVIVHCSAGVGRTGAYIVIDAMLEQAK---KSRTVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVLEALTCGNTEI
   . |||.|||||||||.|..|..| ||.| .   | ..||| ...  ||. ||..||| ||| |.. |.|| | ...| .
llpsggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallellkkkltke
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 235-503 3.9e-92 303.3 In-house 6-277 (281) alignment 
Range on Protein: 235-503
Range on HMM: 6-277/281.0
VAKMQANGGIRLETEYKKFDN-GQQFPWEAARKPANKNKNRYANIVAYDHSRVVLERVNGDEDSDYINASFIHGYDGtPRSFIASQGPLPPAFEDFWRMV
......|    . .||.|. . |.. . .|.....|..|||| ||||||..||.... . ....|||||.|. ||.| .. .||.|||.| ....||.||
lkqlsqndnaGfieeyeklaaigvdntataskadenvlknrYsnivaYDatrvkvtpneenkntDYinanfvpgykg.ekeyiatqgPvPaslvafWqmv

WEQNSQSIVMLTNLVELGKTKCHKYWPDKT--ETYGGVTVTLHQSEIFAEYEIRTFILsKAKQSGSRMVRQFHFTVWPDKGVPQYATAVLAFRRKV-RAL
|||. . |||.|. .| || |||.||||..   .|| |||. ...|  |.|  |.| | ..... .| |.|...| |||.|||. ....| ||..| .. 
weqkvsaivmvtreieagklkChrYWPddnselkygdvtvkstaeeekatyierkfkl.eresgetreveqlaytaWPdhGvPattkellefrkevlklt

NPRDAGPVIVHCSAGVGRTGAYIVIDAMLEQAK-KSRTVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVLEALT
...   |...||||||||||.|| .| ...... . ...|... .  |||.|  ||||  ||.|.. |||.|| 
ekktkaplvihCsaGvGrtGtyialDrlvkaveaeleeldvkavvaelrkernlmvqtvvqyefvykavldald
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 224-522 4.1e-92 303.6 In-house 2-303 (305) alignment 
Range on Protein: 224-522
Range on HMM: 2-303/305.0
KPIPIALFPEYVAKMQANGGIRLETEYKKFDNGqQFPWEAARKPANKNKNRYANIVAYDHSRVVLERVNGDEDSDYINASFIHGYDGTpRSFIASQGPLP
|.| .. . .|. .....    ||..||.. .  . . .  .| |||.|||...|. .|..|. |   . ..||||||||...||..   ..|..||||.
kiialddlaayikearvysdkgleaqykslyee.eesidvgkkeankaknrlkeitlldddriiltekeslddsdyinasyvdgykrk.kkyivaqgPlk

PAFEDFWRMVWEQNSQSIVMLTNLVELGKTKCHKYWPDKTET---YGGVTVTLHQSEIFAEYEIRTFILSK-AKQSGSRMVRQFHFTVWPDKGVPQYATA
   .||||...|   ..|||||.||| || ||..|||...     .| ..|.|.... ...| .| . .|.  ... || | |...| |||.||||.||.
ntvadfWrliveekvstivmltklveggkdkCrqYWpesktekkefgefsvelksektasdyieRklkisiededkesrtvlqyqltdWPdhGvpqfats

VLAFRRKVRALNPRDAG-PVIVHCSAGVGRTGAYIVIDAMLEQAKKSRTVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVLEALTCGNTEIQSENCNQAM
.| . ..|.    .| | |..|||||||||||..|..| .||..||  .||. ..| .||. |. ||||..|| |.| |. | .|||.|.|  .| . ..
llslikrvqkdqkkdkgvpllVhCsagvgRtGvfiavdialerlkkEevvdvfevlkqlRskrmkmvqtldqYvflhdaldelitcgdtsiigsnlrarv

QKLA
.|| 
nklk
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 268-500 1.5e-91 300.9 In-house 2-237 (237) alignment 
Range on Protein: 268-500
Range on HMM: 2-237/237.0
ANKNKNRYANIVAYDHSRVVLERVNGDedSDYINASFIHGYDGTPRSFIASQGPLPPAFEDFWRMVWEQNSQSIVMLTNLVELGKTKCHKYWPD--KTET
 || ||||.||||||||||||.   ..  ||||||....|.||||...||.|||| .. .|||.|||...   ||||| |.|  . |||||||.  . ..
enkiknrygnivaydhsrvvlkgagsg..sdyinatylkgfdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywpstdqpaa

YGGVTVTLHQSEIFAEYEIRTFILSKA-KQSGSRMVRQFHFTVWPDKGVPQYATAVLAFRRKVRALNPR--DAGPVIVHCSAGVGRTGAYIVIDAMLEQA
|| .||.|.. | |..| .|...|||  .. . |.. |..||.|||.||||...|.| ||...   .|   ..|| |.|||||||||| ..|||||| ||
ygvltvslkkkeefsdytvrslllskrltlkevrlihqyqftswpdrgvpqqtaallrfrkniinrsphvsesgpwiihcsagvgrtgiflvidamlrqa

KKSRTVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVLE
|. . ||| ||. .. .|||...|||.|| ||| ..||
kekkvvdiynyvysieedrpyiiqtkdqyvfihqtile
0047943 (Phosphotyrosine protein) phosphatases II 239-502 8.3e-91 299.5 In-house 7-272 (273) alignment 
Range on Protein: 239-502
Range on HMM: 7-272/273.0
QANGGIRLETEYKKFDNGQ-QFPWEAARKPANKNKNRYANIVAYDHSRVVLervnGDEDSDYINASFIHGYDGTPRsFIASQGPLPPAFEDFWRMVWEQN
...|  .|. |.... . . ......|..|.||.|||| .|..||||||.|    ||..|||||||.. ||. ... ||| |||||  .|||||||||||
kllgltllleefelllslkplltysvallpenkdknrykdilpydhsrvkl....gdggsdyinAsyvdgynlkrk.fiatqgPlpntvedfwrmvweqn

SQSIVMLTNLVELGKTKCHKYWPDK----TETYGGVTVTLHQSEIFAEYEIRTFILSKAKQSGSRMVRQFHFTVWPDKGVPQYATAVLAFRRKVRALNPR
.. |||||.|||||. ||..|||..    ..||| .||||   |... | .||..|.. . . ||.|..||.| ||| |||.. . .| | ..||  .  
vrviVmLtelvelgrekcaqYwpleggelsltygkftvtllseetkddytvrtleltnlgtgesrtvthfhytgwpdhgvppslesllefielvrkalea

--DAGPVIVHCSAGVGRTGAYIVIDAMLEQAKKSRTVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVLEAL
  . |||.|||||||||||..|..| .|.| .| ..||. ...  ||. ||.|||| ||| |.. |.|| |
lpsngpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrflyealleyl
0045450 (Phosphotyrosine protein) phosphatases II 222-502 1.9e-90 299.0 In-house 5-304 (307) alignment 
Range on Protein: 222-502
Range on HMM: 5-304/307.0
LSKPIPIALFPEYVAKMQANGGIRLETEYKKFDNGQQF---PWEAARKPANKNKNRYANIVAYDHSRVVLERVNGD-EDSDYINASFI--------HGYD
||..|..  .  .|.......  .|. |..|. . . |   ....|..|.||.|||| .|..|||.||.|  ..|. |||||||||..        .|||
lslfidalkllllvllllldfltgllkefekllsvtvfllgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgyd

GtPRSFIASQGPLPPAFEDFWRMVWEQNSQSIVMLTNLVELGKTKCHKYWPDK--TETYGGVTVTLHQSEIFAEYEIRTFILSKA-KQSGSRMVRQFHFT
  .| ||| |||||  .||||||.|||... |||||.|||||. ||..||||.  . ||| .||||   |. ..| .||. ..   . . ||.|..||.|
l.krkfIatqgPlpetvedFwrmlweqgvtvivmltelvelgrekcaqywPdegeeltygnftvtllseehldgytvrtlevtdldgtgesrtvthfhyt

VWPDKGVPQYATAVLAFRRKVRALNPR--DAGPVIVHCSAGVGRTGAYIVIDAMLEQAKKSRT---VDIRNYLIALRKDRPHMVQTKEQYSFIHSAVLEA
 ||| |||..   .|.| ..||. . .  . |||.|||||||||||..|... ||.| .|  |   ||... .  ||. ||..||. ||| |.. |.|| 
gwpdhgvppsfeelldfieevrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyeallel

L
|
l
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 233-501 1.2e-89 295.2 In-house 10-278 (288) alignment 
Range on Protein: 233-501
Range on HMM: 10-278/288.0
EYVAKMQANGGIRLETEYKKF-DNGQQFPWEAARKPANKNKNRYANIVAYDHSRVVLERVNGDEDSDYINASFIHGYDGTpRSFIASQGPLPPAFEDFWR
..|||..|..   .. ||..    ...   .|.|.. |..|||| ||..||. || |. ..  ...||||||.|.|.... . .||.||||. . .|||.
akvakksarnrtgfseeynsLaalektksvtagrlavnakknRyrnilpyDekrvklkkleeeagaDYinasyidgekkk.kkyiatqgPladtvndfWe

MVWEQNSQSIVMLTNLVELGKTKCHKYWPDKTE--TYGGVTVTLHQSEIFAEYEIRTFILSkaKQSGSRMVRQFHFTVWPDKGVPQYATAVLAFRRKVRA
.|.|.... |||||.||| |||||..||||. .   || ||||| .|.   ..  |...|   |. . . . |.....|||.|||. .. .|...|.|  
lvyenktstivmltelveggktkCeeYWPdadkpknyGsvtvtlveskeledfvlrkllle..kkkteleitqyqylaWpdhgvPeskapllellrqvkv

LNPRDAGPVIVHCSAGVGRTGAYIVIDAMLEQAKKSRTVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVLEA
 |. |.||.|||||||||||| .|..||.... ... ..|. . .  ||| |. .|||..|| ||....|. 
anqadtgpiivhCsaGvGrtgtFialdalidaveeedyiDvagtvaklRkqRallvqtlkqYefiyevllsl
DSPc_SM00195 246-502 1.6e-87 288.5 In-house 2-262 (263) alignment 
Range on Protein: 246-502
Range on HMM: 2-262/263.0
LETEYKKFDNGQ-QFPWEAARKPANKNKNRYANIVAYDHSRVVLERVNGDEDSDYINASFIHGYdGTPRSFIASQGPLPPAFEDFWRMVWEQNSQSIVML
|..|..| .. . . . . |.|..||.|||| ||. |||.|| |.. ...|.||||||..| |.   ....|| |||||  .|||||||||.... ||||
lkeefekleestspketteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikga.nkkkkyIatQgPlpstvedFWrmvweekvkiivml

TNLVELGKTKCHKYWPDK---TETYGGVTVTLHQSEIFA-EYEIRTFILSKAKQSGSRMVRQFHFTVWPDKGVPQYATAVLAFRRKVRALNPRDAGPVIV
|. .| ||.||..|||..   .||.| ..|.| . |.   |...||. |.| ... .| |.|.... |||.|||. .. ||.. |.|.  . .  ||..|
teeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkkskstssgpivV

HCSAGVGRTGAYIVIDAMLEQAKKSRTVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVLEAL
||||||||||....|| .|.. ..  .||| . . .||| ||.||||.|||.||. |.||..
hCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi
PTPc_SM00194 246-502 1.6e-87 288.5 In-house 2-262 (263) alignment 
Range on Protein: 246-502
Range on HMM: 2-262/263.0
LETEYKKFDNGQ-QFPWEAARKPANKNKNRYANIVAYDHSRVVLERVNGDEDSDYINASFIHGYdGTPRSFIASQGPLPPAFEDFWRMVWEQNSQSIVML
|..|..| .. . . . . |.|..||.|||| ||. |||.|| |.. ...|.||||||..| |.   ....|| |||||  .|||||||||.... ||||
lkeefekleestspketteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikga.nkkkkyIatQgPlpstvedFWrmvweekvkiivml

TNLVELGKTKCHKYWPDK---TETYGGVTVTLHQSEIFA-EYEIRTFILSKAKQSGSRMVRQFHFTVWPDKGVPQYATAVLAFRRKVRALNPRDAGPVIV
|. .| ||.||..|||..   .||.| ..|.| . |.   |...||. |.| ... .| |.|.... |||.|||. .. ||.. |.|.  . .  ||..|
teeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkkskstssgpivV

HCSAGVGRTGAYIVIDAMLEQAKKSRTVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVLEAL
||||||||||....|| .|.. ..  .||| . . .||| ||.||||.|||.||. |.||..
hCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi
subfamily_Ptp69D_pd Subfamily Ptp69D 231-521 1.3e-85 282.2 In-house 9-305 (307) alignment 
Range on Protein: 231-521
Range on HMM: 9-305/307.0
FPEYVAKMQANGGIRLETEYKKFD-NGQQFPWEAARKPANKNKNRYANIVAYDHSRVVLERVNGDEDSDYINASFIHGYDGTpRSFIASQGPLPPAFEDF
 .| . . . .    |. ||.|   .  .   ... |  |. |||| .|.|.|. ||.|...||.|||||||||||.||. . ..|||.|.|.    .||
leealksrkrdtdfglakeyekLeareidkstkvsekkenalknRyedikafDktRvkLkkingkedsdYinasfikgykek.kkfiaaqdPveatigDf

WRMVWEQNSQSIVMLTNLVELGKTKCHKYWP-DKTETYGGVTVTLHQSEIFAEYEIRTFILSKAKQSG-----SRMVRQFHFTVWPDKGVPQYATAVLAF
|||..||... ||||.|| |  . ||.|||| ...  || . |.| ..|   .| ||.. .|| |...     || | |.|.| |.|  ||. |...| .
WRmiaeqevtlivmlsnlteknrkkcakYWpiedevqygdilvklvseekhsdyiiReldvskkkeesgevedsrkvvqyhytgWkDskvPevargllkl

RRKVRALNPRDAGPVIVHCSAGVGRTGAYIVIDAMLEQAKKSRTVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVLEALTCGNTEIQSENCNQAMQKL
 ..|| |.  . .|..|||||||||.| .. .| .|.| |.  .||| .    ||..|. .||  |||.|.. |.|.  . |.|... .. ..|...|
ieqvrelyklnrsPivvhCsaGvgrsgifvaldsllqqlkaedkvdifetvkdLrsqRnllvqsleqYvflyralldyssygdtdedvddledaierl
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 262-521 4.8e-84 277.4 In-house 54-310 (319) alignment 
Range on Protein: 262-521
Range on HMM: 54-310/319.0
EAARKPANKNKNRYANIVAYDHSRVVLERVNGDEDSDYINASFIHGYDgTPRSFIASQGPLPPAFEDFWRMVWEQNSQSIVMLTnlvelgKTKCHKYWPD
. |  . ||.|||. ||.|.|...| |||..| | ||||||||. ||   .  .||.||||. . .|||||.||.|. .||.||      | || .||| 
tfanldqnkdknriinilafdknvvklerliGeefsdyinasfvtGyq.rkdkyiaaqGPldntladfWrmiweyncstivllt......kdkcsqywpl

KT-ETYGGVTVTLHQSEIFAEYEIRTFILSK-AKQSGSRMVRQFHFTVWPDKGVPQYATAVLAFRRKVRALNPRDAG--PVIVHCSAGVGRTGAYIVIDA
|. ....   | ..  |  ||| .| . ||. .|. . | ..||||  |||.|||.|.. .. . .||| |. .  .  ...|||||||||||.|||.|.
kivikeerfkvkvdsveetaeyvvrdielsedgkekdirkitqfhflGwpdvGvpdypsdlmrlvkkvrhltskenhranivvhcsaGvGrtGvyivldv

MLEQAKKSRTVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVLEALTCGNTEIQSENCNQAMQKL
.|.. |. . ||. |..  ||..|...||   || ||.||.||    |....   .    ...|
lldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalleehlfghsdvampdfpayleel
0040439 (Phosphotyrosine protein) phosphatases II 260-502 6.4e-84 276.7 In-house 2-246 (249) alignment 
Range on Protein: 260-502
Range on HMM: 2-246/249.0
PWEAARKPANKNKNRYANIVAYDHSRVVLERVNGDEDSDYINASFIHGYDGTPRsFIASQGPLPPAFEDFWRMVWEQNSQSIVMLTNLVELGKTKCHKYW
... |..|.||.|||| .|..||||||.|. ..| ..|||||||.|.||. ..| ||| ||||| ..||||||.||.....|||||.|||||. ||..||
eysvallpenkdknrypdilpydhsrvklsilpglflsdyinAsyidgyyikrr.fiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqyw

P-DKTETYGGVTVTLHQSEIFAEYEIRTFILSKAKQSGSRMVRQFHFTVWPDKGVPQYATAVLAFRRKVRALNPR--DAGPVIVHCSAGVGRTGAYIVID
| ... .||..|||| . |....| .||. |.. . . ||.|.....| ||| |||..   .|.| ..||  . .  . |||.|||||||||||..|...
plggsleygdftvtllsvevkddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaay

AMLEQAKKSRTVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVLEAL
 |||| .| ..||. ...  ||. ||..||. ||| |.. |.|| |
lmleqlekelgvdleeavkllrsqRpgavqnpeqyrflyeallell
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 225-546 2.4e-83 275.0 In-house 1-320 (515) alignment 
Range on Protein: 225-546
Range on HMM: 1-320/515.0
PIPIALFPEYVAKMQANggIRLETEYKKFDNGQQFPWEAARKPANKNKNRYANIVAYDHSRVVLERVNGDEDSDYINASFIHGYDGtPRSFIASQGPLPP
|.|.| || .|.| .      .  |.. .   . .|   |..  | .|||| ||. || .|| || .| . .|||.|||.|...|   ...||||||.. 
plplaqfPafvnknrht..tlfseefhdlpgpniypqtvaqeeinfkknryknilPydsvrvklevindnPhsdyfnasyipsfdn.dkayiasqgPnka

AFEDFWRMVWEQNSQSIVMLTNLVELGKTKCHKYWPD---KTETYGGVTVTLHQSEIFAEYEIRTFILSKAKQsgSRMVRQFHFTVWPDKGVPQYATAVL
. .||||.|...|   |.|.|.| |  | || |||||   ..  .| . | |   |  ..  .|.. . | ..  || | ||||| |||||||. ....|
svddfWrlvlqenvttiamvtklkegdkikcgkyWPdkpgdsvkfGsikvelvsleactggikrkltvlkgdd..srtvtqfhfteWPdkGvpkhtssll

AFRRKVRALNPRDAGPVIVHCSAGVGRTGAYIVIDAMLEQAKKSRTVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVLEALTCGNTEIQSENCNQAMQKL
 . ..|.| . . . |.|.|||||||||| .| || .. .||..|.||. |..  .|..||..|||.|||.||. |||| |   || |      . .| |
klikevkadhgqythpliihcsaGvGrtGvvisidsvvahakttrmvdvfnfvtnirqkrpylvqtqeqyafiygavledllwrntlipvihftdhlqdl

ASVNRKFQMTGYALEFQRLNSVTSR
 |       .  . ||| |.|..  
hssgdgrgrskmtkefqtlkslcpd
Y_phosphatase Protein-tyrosine phosphatase 269-500 3.1e-83 274.1 Pfam-A 1-235 (235) alignment 
Range on Protein: 269-500
Range on HMM: 1-235/235.0
NKNKNRYANIVAYDHSRVVLervNGDED-SDYINASFIHGYDgTPRSFIASQGPLPPAFEDFWRMVWEQNSQSIVMLTNLVELGKTKCHKYWP---DKTE
||.|||| .|..||..|| |   .|.|. ||||||....||. ....|||.||||.  .||||||||......|||||.|.| |..||..|||   ....
nkkknRykdilpydktrvkl...kgsegpsdYInAnyvkgyk.ekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeesl

TYGGVTVTLH-QSE-IFAEYEIRTFILSKAKQS-GSRMVRQFHFTVWPDKGVPQYATAVLAFRRKVRALNPRDAGPVIVHCSAGVGRTGAYIVIDAMLEQ
||| ..|.|  ... . .|| .|.. |.| |..  .|.|.|.|.| |||.|||. ....| . |||.  .  . |||.||||||||||| ....|..|||
tygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleq

AKKSRTVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVLE
... ..||. ...  ||| ||.|||. ||| |.. |.||
leaeeevdvlqivkelRkqRpgmvqsleqYiflykaile
Y_phosphatase Protein-tyrosine phosphatase 269-500 3.1e-83 274.1 In-house 1-235 (235) alignment 
Range on Protein: 269-500
Range on HMM: 1-235/235.0
NKNKNRYANIVAYDHSRVVLervNGDED-SDYINASFIHGYDgTPRSFIASQGPLPPAFEDFWRMVWEQNSQSIVMLTNLVELGKTKCHKYWP---DKTE
||.|||| .|..||..|| |   .|.|. ||||||....||. ....|||.||||.  .||||||||......|||||.|.| |..||..|||   ....
nkkknRykdilpydktrvkl...kgsegpsdYInAnyvkgyk.ekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeesl

TYGGVTVTLH-QSE-IFAEYEIRTFILSKAKQS-GSRMVRQFHFTVWPDKGVPQYATAVLAFRRKVRALNPRDAGPVIVHCSAGVGRTGAYIVIDAMLEQ
||| ..|.|  ... . .|| .|.. |.| |..  .|.|.|.|.| |||.|||. ....| . |||.  .  . |||.||||||||||| ....|..|||
tygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleq

AKKSRTVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVLE
... ..||. ...  ||| ||.|||. ||| |.. |.||
leaeeevdvlqivkelRkqRpgmvqsleqYiflykaile
0050432 (Phosphotyrosine protein) phosphatases II 501-802 5.2e-83 274.2 In-house 11-306 (308) alignment 
Range on Protein: 501-802
Range on HMM: 11-306/308.0
ALTCGNTEIQSENCNQAMQKLAS-VNRKFQMTGYALEFQRLNSVTSreipAEEKSVGEEPQNLHKNRFSDIIALNSCRVMLhkehaDEESDYINAVFLHA
.|....|.|. .. .. ...|.  ..........  ||..|.||.      .| ||.. |.| .|||..||... ..|| |     ||.|||||| . . 
lllfrdtsilvsslklsvldllkllekaldlglleeefeellsvkp....lleysvallpenkdkNrykdilpydhsRVkl.....degsdYInAsyvdg

H--RGRNAFIATQHPLLETVEDFWRMVTDYDIGTIVMLNNLHELD-QEYPKYWPDH---GPTKYGHIGVSVLSKQEQGDVICTKLKVTRKKVRrKTHEVR
.  . ...|||||.|| .||||||||| .... .||||..|.| . . ...|||.    |...||.. | .|| ....|.....|..| ..   ....|.
yssklprkfIatqgPlpntvedFwrmvweqnvrvIvmLtklvengrekcaqYwplelgggsleygkftvtllseevlddytvrtleltnlgdg.esrtvt

HLHHVSWPDKCIPEVACSVLDLLDEAQTSQqqcGNAPVLVQCSNGVGRSGTFCAISSVLERLKTEQVIDVFQVIKRIRVNLPGAVESPTQYMFCYQIIQK
|.|. .||| ..|. . ..||.|.....|.   .. |..| ||.||||.|||.|.  .||.|..|. .|||...|..|   ||.|..| ||.|.|.....
hfhytnWpdhgvPpspeilldflelvrksl...pggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtpeqylflyralle

YLDSFSDYA
|| ..  ..
ylklkltkl
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 224-523 6.9e-83 273.1 In-house 1-298 (315) alignment 
Range on Protein: 224-523
Range on HMM: 1-298/315.0
KPIPIALFPEYVAKMQANggIRLETEYKKFDNGQQFPWEAARKPANKNKNRYANIVAYDHSRVVLERVNGDEDSDYINASFIHGYDGtPRSFIASQGPLP
.|||.| || .| | .      .  |.. . . . ..  .||.. | .|||| ||. .|..||.|| .. . ||||||||.|...|   ...|||||||.
qpipvaqfpafvnknrht..alfseefhdlpdPdiyrqrvaretinfkknryknilPldsarvkleviddsPdsdyinasyiksvdd.dkayiasqgPlk

PAFEDFWRMVWEQNSQSIVMLTNLVELGKTKCHKYWPD---KTETYGGVTVTLHQSEIFAEYEIRTFILSKAKQsgSRMVRQFHFTVWPDKGVPQYATAV
 . .||||||....  .|||.|.. |  | || .||||   ..  .| . |.| . |  ..  .| ... |...  || | ||.|| ||||||.. ....
asvddfwrmvlqekvttivmvtkkqegdkikcrqywPdrkadsvefGsikvellsleadtdgvarklvtrksee..srtvtqfqftewPdkGvdkqtssl

LAFRRKVRALNPRDAGPVIVHCSAGVGRTGAYIVIDAMLEQAKKSRTVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVLEALTCGNTEIQSENCNQAMQK
| . ..|.| | ..  ...|||||||||||  | || ...|.|..|.||. |..  ||..||..|||.|.|.||. |||| |   || |   .  . .| 
lklikevkadngkkefsllvhcsaGvGrtGvvisidevvaqikrtrsvdvfnfvknlrakrpylvqteeeyafiydavledllwrntlilvihftdhlqd

LAS
| .
lht
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 266-521 1e-82 272.8 In-house 22-274 (284) alignment 
Range on Protein: 266-521
Range on HMM: 22-274/284.0
KPANKNKNRYANIVAYDHSRVVLERVNGDEDSDYINASFIHGYDgTPRSFIASQGPLPPAFEDFWRMVWEQNSQSIVMLTnlvelgKTKCHKYWPDKT-E
 . ||.|||. .|.|.|...| |||. | | ||||||||| ||   .  .||.||||. . .|||||.||.|. .||.||      | || .||| |. .
ldqnkdknrighilafdknvvklerliGeefsdyinasfitGyq.rkdkyiatqGPldntladfWrmiweyncstivllt......kdkcsqywplkivi

TYGGVTVTLHQSEIFAEYEIRTFILSK-AKQSGSRMVRQFHFTVWPDKGVPQYATAVLAFRRKVRALNPRDAG--PVIVHCSAGVGRTGAYIVIDAMLEQ
...   | ..  |  .|| .| . ||. .|. . | .|||||  |||.|||.|.. .... .||| |. .  .  ...|||||||||||.|||.|..|..
keerfkvkvdsveeseeyvvrdielsedgkekdirkirqfhflgwpdvgvpdypsdlmrlvkkvrhltskenhranivvhcsagvgrtgvyivldvlldr

AKKSRTVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVLEALTCGNTEIQSENCNQAMQKL
 |. . ||. |..  ||..|...||   || ||.||.||    |....   .    ...|
mkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalleehlfghsdvalpdfpayleel
0042113 (Phosphotyrosine protein) phosphatases II 262-501 7.5e-82 269.7 In-house 2-242 (245) alignment 
Range on Protein: 262-501
Range on HMM: 2-242/245.0
EAARKPANKNKNRYANIVAYDHSRVVLERVNGDEDSDYINASFIHGYDGTPRsFIASQGPLPPAFEDFWRMVWEQNSQSIVMLTNLVELGKTKCHKYWP-
. |..|.||.|||| .|..|||.||.|  ..||.||||||||...||. ||. |||.|||||  .||||||.||.....|||||...|||. ||..||| 
svallpenkdknrysdilpydhtrvklspdggdldsdyinasyvdgyritpk.fiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywpl

DKTETYGGVTVTLHQSEIFAEYEIRTFILSKAKQSGSRMVRQFHFTVWPDKGVPQYATAVLAFRRKVRALNP-RDAGPVIVHCSAGVGRTGAYIVIDAML
. . |||..||||   |....| .||. ... . . ||.|...|.. ||| ||| .   .| | . ||      . |||.|||||||||||..|... ||
gesltygdftvtllseehlddytvrtlevtnlgddesrevihyhylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylml

EQAKKSRTVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVLEA
||..| ..|.. . .  ||. ||..||| .|| |.. |.|| 
eqlekelgvsleeavkelrsqRpgavqtpsqyrflyeallel
subfamily_PTPN6_pd Subfamily PTPN6 251-500 1.1e-81 269.2 In-house 36-295 (306) alignment 
Range on Protein: 251-500
Range on HMM: 36-295/306.0
KKFDNGQQFPWEAARKPANKNKNRYANIVAYDHSRVVLErVNGDEDSDYINASFIH-GYDGTPRSFIASQGPLPPAFEDFWRMVWEQNSQSIVMLTNLVE
.. .. ...  . ..|| ||.|||| ||. .||.||.|.  ..  .||||||..|.    |. .|.||.|| |.   .|||||||..||. |||.|. ||
qqeeakkllsrkegakpenkeknryknilPfDhtrvilk.epsvpgsdyinanyikkevkgsdksyiatqgclettvsdFWrmvwqensrvivmttkevE

LGKTKCHKYWPDKT--ETYGGVTVTLHQSEIFAEYEIRTFILSK-AKQSGSRMVRQFHFTVWPDKGVPQYATAVLAFRRKVRA----LNPRDAGPVIVHC
 || || .||||..  |.|| ..||  ...  |.|..|.. .||  |.. .| |.|.||..|||.|||.   |||.| ..|..    |. ..|||..|||
rgkekCarYWPdeeekeeyGkisvtnvseksladYilRelsvskkkkkkeerevfqyhfksWPdhgvpkdpgavLdfledvnrkqeeleeaeagpivvhC

SAGVGRTGAYIVIDAMLEQAKKS---RTVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVLE
|||.||||..||||..|.. .|.     .||..    .|. |  .|||..|| |.. |. .
saGiGRtGtfiviDillkliekkgldadidiqklvksvreqrsglvqteqqykfvykaikk
0051299 (Phosphotyrosine protein) phosphatases II 505-795 2e-81 268.9 In-house 1-286 (288) alignment 
Range on Protein: 505-795
Range on HMM: 1-286/288.0
GNTEIQSENCNQAMQKLAsvnrKFQMTGYALEFQRLNSVTSReipaEEKSVGEEPQNLHKNRFSDIIALNSCRVMLHKEHADEESDYINAVFLHAHRGRN
|.|||. |.  ....||     . ..||.. ||..| |..       . |..  |.||.|||.|||......|| |. .. .|.|||||| ... ..  .
gdteisveellklvlkll....angltglleefeellsllpd....ltlsaallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyidgynlkr

AFIATQHPLLETVEDFWRMVTDYDIGTIVMLNNLHELD-QEYPKYWPDHGPTKYGHIGVSVLSKQEQGDVICTKLKVTRKK---VRRKTHEVRHLHHVSW
.|||||.|| .||||||||| .... .||||..|.||. . ...|||..|...||.| |  || ....|.....|.||...      ....|.|.|. .|
kfIatqgPlpntvedFWrmvweqnvrvIvmltklvelgrekcaqYwplggsltygditvtllseevlddytvrtlevtnldlldgdgesrtvthfhytnw

PDKCIPEVACSVLDLLDEAQTSQQqCGNAPVLVQCSNGVGRSGTFCAISSVLERLKTEQVIDVFQVIKRIRVNLPGAVESPTQYMFCYQIIQKYL
|| ..|. . ..||.| .......  |. ||.| ||.||||.|||.|.  .||.|..|...||....||.|   ||.|..| ||.|.|...  ||
pdhgvpdspellldflrlvrkala.sgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtpeqyrfvyealleyl
subfamily_PTPN12_pd Subfamily PTPN12 245-502 5.3e-81 266.7 In-house 16-277 (290) alignment 
Range on Protein: 245-502
Range on HMM: 16-277/290.0
RLETEYKKFDNGQQFPWEAARKPANKNKNRYANIVAYDHSRVVLERVNGDEDSDYINASFIHGYDGTpRSFIASQGPLPPAFEDFWRMVWEQNSQSIVML
.| .. .|. . .... ||..|. |..|||| .|. ||.|||.|.. ...|.||||||.||.| .|.  ..||.||||| . .|||||.||.| . .||.
klkklsekykaekvysteagekeenvkknrykDilPydksrvelskieeeegsdYinanfikgvegk.leyiaaqgPLpktlddfWrmiweknveivvma

TNLVELGKTKCHKYWPDKT---ETYGGVTVTLHQSEIFA-EYEIRTFILSkaKQSGSRMVRQFHFTVWPDKGVPQYATAVLAFRRKVRALNPRDAGPVIV
 ..|||||.||..|||...    ..| ..|||.. . .  .. |||. .   .|. ||.|.|||.| |||.|||. |. .|.. ..|| |. ... |..|
CrevelgkkkCerYWpeegeeelefgefevtleeekavdddflirtLkve..aqkesrkvyqfhYtaWPDhgvPssaksllelielvrelqesedaPlvv

HCSAGVGRTGAYIVIDAMLEQ---AKKSRTVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVLEAL
||||||||||. |.|| . |.    | . ..|. . .. |||.|. .|||||||.... ||.| .
hCsaGvGrtGtiiaidyvrellkaekipeeldvfdlvlelrkqraalvqtkeqyelvykavaelv
0045098 (Phosphotyrosine protein) phosphatases II 252-505 3.7e-80 264.5 In-house 16-275 (278) alignment 
Range on Protein: 252-505
Range on HMM: 16-275/278.0
KFDNGQQFPWEAARKPANKNKNRYANIVAYDHSRVVlervngdedsDYINASFIHGYdgtPRSFIASQGPLPPAFEDFWRMVWEQNSQSIVMLTNLVELG
..  |.   .. | .. |..|||| .|..||||||.          ||||||.|.||   |. ||| |||||  ..|||||.||.....|||||.|||||
llllgipseitpalylgnldknRykdilpydhsrVk..........dYINAsyidgy...pkkfIatqgPlpstvadfwrmlwelgitvivmltelvelg

KTKCHKYWPDKT-ETYGGVTVTLHQSEIFAEYEIRTFILSKA----KQSGSRMVRQFHFTVWPDKGVPQYA--TAVLAFRRKVRALNPR-----------
. ||..|||..  .|||..|||| . |.. .| .||...       .   || |...|.. ||| ||| .   . .| . . .|. . .           
rekcaqywpeggsltygdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslll

--DAGPVIVHCSAGVGRTGAYIVIDAMLEQAkkSRTVDIRNYLIALRKDRPH-MVQTKEQYSFIHSAVLEALTCG
  . |||.|||||||||||...... |||.    ..||. ...  ||. ||. .||..||| |.. ..|| | .|
ldsggpvlVHCsaGvgRtGtlvaaylmlell..eggvdlleavkelrsqRpglavqnleqyrflyefllelllrg
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 551-805 2.9e-78 258.1 In-house 38-290 (318) alignment 
Range on Protein: 551-805
Range on HMM: 38-290/318.0
EEKSvgEEPQNLHKNRFSDIIALNSCRVMLHKEHADEESDYINAVFLHAHRGRNAFIATQHPLLETVEDFWRMVTDYDIGTIVMLNNLHELDQ-EYPKYW
. ||   || | .|||. .|.| ...|| |.. . .|.|||||| ..  .| ..|.||.| || ||.||||||| . .  .|||| ...|  .    .||
slks..lepvnkaknryanilaydhtrvkLqmlegeegsDyinanyidGyrrkkayiaaqaPlpetieDfWrmvWeqnsavivmltqeeergkakvhryW

PDHGPTKYGHIGVSVLSKQEQGDVICTKLKVTRKKVRrKTHEVRHLHHVSWPDKCIPEVACSVLDLLDEAQTSQQQCGNAPVLVQCSNGVGRSGTFCAIS
|..|...||.. | . .. | .| .  ..||||...  .. .||  |. ||||. .|| ..|.|||. .... ||..|. |..| || |||| |.|.|..
Pskgsrsygklvvelkeevelsdyvlrefkvtrteee.esrqvrqyhytsWpdegvpesgaslldlvrqvskaqqksgagpivvhCsaGvGrtGvfiavd

SVLERLKTEQVIDVFQVIKRIRVNLPGAVESPTQYMFCYQIIQKYLDSFSDYANYS
..|||.| |...||||..|..| . .  |    || |.|......| |.  ... |
illerikaealvDvfqtvkqlreqrnlmvqtedqyefiydvllealasgdtevdas
0046845 (Phosphotyrosine protein) phosphatases II 535-801 3.1e-78 258.3 In-house 4-280 (284) alignment 
Range on Protein: 535-801
Range on HMM: 4-280/284.0
LEFQRLNSVTSREIpaEEKSVGEEPQNLHKNRFSDIIALNSCRVMLHKEHAD-EESDYINAVFLHAH-----RGRNAFIATQHPLLETVEDFWRMVTDYD
 ||..|.|.|   .   . ||.  |.||.|||..||......|| |. .. | |.|||||| ... .     . ...|||||.|| .||||||||| ...
eefeellsltvkll..lslsvallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweqn

IGTIVMLNNLHELDQ-EYPKYWPDHG-PTKYGHIGVSVLSKQEQGDVICTKLKVTRKKVRRKTHEVRHLHHVSWPDKCIPEVACSVLDLLDEAQTSQQQ-
. .||||..|.| ..  ...|||. | . .||.. | .||.....|.....|..|....  ....|.|.|. |||| ..|. . ..|..|......... 
vrvIVmltelvengrekcaqYwplegevltygdftvtllseevkddytvrtleltnlgytgesrtvthfhytswpdhgvppspedlleflrlvrellenl

CGNAPVLVQCSNGVGRSGTFCAISSVLERLKTEQ---VIDVFQVIKRIRVNLPGAVESPTQYMFCYQIIQKYLDSFSDY
 |. |..| ||.||||.|||.|.  .||.|..|.   ..||....||.|   ||.|... ||.|.|.... || ..  .
pgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyealleylklkltl
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 224-512 4.2e-78 257.5 In-house 8-294 (297) alignment 
Range on Protein: 224-512
Range on HMM: 8-294/297.0
KPIPIALFPEYVAKMQANGGirLETEYKKFDNGQQFPWEAARKPANKNKNRYANIVAYDHSRVVLERVNGDEDSDYINASFIHGYDGtprSFIASQGPLP
.|||.. |. .| | .       . |..   . . .|   |.|  | .|.||.||. || ||| |. || | ||||.||||..|.      .|..| | .
rpiplsdfatlvqknrhtdv..fseeflclpeaniqpqtvaekkvnfeksRYkniLPydssRvkLaivnddpdsDyvnasfvkgnkh...rlittqmPmk

PAFEDFWRMVWEQNSQSIVMLTNLVELGKtKCHKYWPDKT-ETYGGVTVTLHQSEIFAEYEIRTFILSKAKQSGSRMVRQFHFTVWPDKGVPQ--YATAV
 . .|||.||.... . ||||... |  | || .||.||.  |.| |.|.|.  .    .  |.. ..| |    |.|.|..|. |||| |..   |...
atvadfWamvldeqvstivmlnddnerdk.kcaryWsdkgvttfGdvsvvllsvsereGfikrelevtkgkakarrvvkqyqfveWPdkaverkdsassl

LAFRRKVRALNPRDAG-PVIVHCSAGVGRTGAYIVIDAMLEQAKKSRTVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVLEALTCGNTEIQSE
| .   ||      |  |..|||.||||||| .. || .. .||.  .||| ...  ||..||..|||||||.|.. |||||| . .|.||..
lklisevrkdfsqnaegPllvhclaGvGrtgvlltidsvvaeakrekevdifglvkklrqerpylvqtkeqykfvyvavleallsedtriqas
0037934 (Phosphotyrosine protein) phosphatases II 261-500 8.7e-78 256.5 In-house 2-240 (243) alignment 
Range on Protein: 261-500
Range on HMM: 2-240/243.0
WEAARKPANKNKNRYANIVAYDHSRVVLervngdEDSDYINASFIHGYDgtpRsFIASQGPLPPAFED----FWRMVWEQNSQSIVMLTNLVELGKTKCH
.  |..|.|..|||| .|..||||||.|      |.||||||..| ...   | .||.|||||  .||    ||||.||.....|||||.|||||. ||.
fsiallpenlsknrysdilpydhsrvkl......egsdyinanliyvtp...r.liatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekca

KYWPDKTeTYGGVTVTLHQSEIFAEYEIRTFILSKAK-QSGSRMVRQFHFTVWPDKGVPQYATAVLAFRRKVRAL--------NPRDAGPVIVHCSAGVG
.|||... |||..|||| ..| ...| .||. |.  . .  .|.|...|.. ||| |||.  . .|.| ..||.         .  . |||.||||||||
qywpgev.tygdftvtllseehlddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvg

RTGAYIVIDAMLEQAkksrTVDIRNYLIALRKDRPH-MVQTKEQYSFIHSAVLE
|||..|... ||..     .||. ...  ||. ||. .||| .|| |.. |.||
RtGtliaaylmllll....gvdleeavkllreqRpgkavqtpsqyrflyealle
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 531-799 4.9e-77 254.1 In-house 23-287 (319) alignment 
Range on Protein: 531-799
Range on HMM: 23-287/319.0
TGYALEFQRLNSVTSReipaeEKSVGEEPQNLHKNRFSDIIALNSCRVMLHKEHADEESDYINAVFLHAHRGRNAFIATQHPLLETVEDFWRMVTDYDIG
|. . ||. |.  ..      . .  ....| .|||...|.| . .||.| . .  |.|||||| |. ... |..||||| || .|.||||||| .... 
tllekefkllkeavnd.....tfdsaskeenkkknryqnilaydrtrvvlseldgvegsdyinasfidgyqerekfiatqaPlentiedfWrmvWeeess

TIVMLNNLHE-LDQEYPKYWPDHGPTKYGHIGVSVLSKQEQGDVICTKLKVTRKKVRRKTHEVRHLHHVSWPDKCIPEVACSVLDLLDEAQTSQQQCGNA
..|||..| | |. .. ||||.. ...||.. | .....|. |.|  |||. .|.   .| || | .. .|||. .|| | |.|||| . . |...  . 
ivvmltklveklkvklkkywpeenfeeyGrlivtleeeeeledyiirklklnkkssevetRevkhfqyteWpdhdvPekatslldllkrirksrektqsg

PVLVQCSNGVGRSGTFCAISSVLERLKTEQVIDVFQVIKRIRVNLPGAVESPTQYMFCYQIIQKYLDSFS
|. | ||.|||| |||.... .|||.| |.|.|||....|.|.  .  |. | || |.|... .......
PivvhCsaGvGRtGtfivldamlervkeegvlDvfstvsrlRtqRnimvqrpeqYkfiyealleaveagd
subfamily_PTPN9_pd Subfamily PTPN9 231-500 1.4e-76 252.3 In-house 6-288 (297) alignment 
Range on Protein: 231-500
Range on HMM: 6-288/297.0
FPEYVAKMQANGgirLETEYKKFDNGQ-QFPWEAARKPANKNKNRYANIVAYDHSRVVLERVNGDEDSDYINASFIHGYDgTPRSFIASQGPLPPAFEDF
. .|| ... .|   |  ||..  | . .   .|....|| .||||.... ||..||||..|..|| ||||||.|. ||   ...||| ||||. ...||
lvayvkekgkrG...lskeyaeirnepveGtflasklranleknrytdvlcydetrvvlakvdedeasdyinanfvdGyk.qkkafiatqGplkktvsdf

WRMVWEQNSQSIVMLTNLVELGKTKCHKYWP---DKTETYGGVTVTLHQSEIFAEYEIRTFILSKAKQSGSRMVRQFHFTVWPDKGVPQYATAVLAFRRK
|||||||.   ||| | .|| |. || .|||   .... .| ..|.  . |   .|..|.. ....|.. || |  | |. ||| |||. |...| ...|
WrmvWeqevlvivmttrvvergrlkcgqyWpleeessaefgdlsvsnveveeeedykvrvleiknvkteesrkvthfqflsWPdyGvPssaaslldvlek

VRA--------LNPRDA-----GPVIVHCSAGVGRTGAYIVIDAMLEQAKKSRTVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVLE
||         | ....      |..||||||.||||..| .|  |.. ..  |||... .  ||. | ...|| ||| | . ||||
vrekqalavkelgdewkghpsgPPivvhcsaGiGrtGtfitldiclsrleevgtvdvvetvkllrtqrafsiqtpeqyefcylavle
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 235-522 6.9e-76 250.4 In-house 14-308 (325) alignment 
Range on Protein: 235-522
Range on HMM: 14-308/325.0
VAKMQANGGIRLETEYKKFDNGQQFPWEAARKPANKNKNRYANIVAYDHSRVVLERVNGDEDSDYINASFIHGYDGTpRSFIASQGPLPPAFEDFWRMV-
| | .|.    .  |..   . .    ..| ||.||.|||. |.||.|.||||||  . | .|||||||... . .    |.|.| ||. . .|.||.| 
vekkkaqdqdgfahefgllpsddgiakkvamkpenkaknrfknvvaldksrvvletkkddpssdyinasylrddkkk.dvflaaqaPltatindlWrlvl

-WEqnsQSIVMLTNLVELGKTKCHKYWPDK---TETYGGVTVTLHQSEIFAEYEIRTFILSKAKQSGSRMVRQFHFTVWPDKGVPQYATAVLAFRRKVRA
 |.    |.|...| ..||| .| .|||..   . |.||. | |   | ...|  | . . ..|.  .| |.||..  |.| ||... ...... . | |
dWr...csvvvvlneldlgkdrcavywpkemgksktfGglevklrtieeisdyvhrvldvkqvkkGetrsvkqfqlqswddmGvqkrpatlisilqlvka

L------NPRDAGPVIVHCSAGVGRTGAYIVIDAMLEQAKKSRTVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVLEALTCGNTEIQSENCNQAMQKLA
.      | . ..|..|||||||||||..| . ..|..  .   ||| ...  |||||| ||.| .||..|. |. ||. .|||..   . .  .  | 
vservtantkastpilvhcsaGvGrtGvfislysalakvieesrvdifgfvkklrkdrpsmvetvdqyiliyealveaymsgntdvpvssfeaklsslq
0040438 (Phosphotyrosine protein) phosphatases II 527-796 1.4e-75 249.8 In-house 14-277 (317) alignment 
Range on Protein: 527-796
Range on HMM: 14-277/317.0
KFQMTGYALEFQRLNSVtsreiPAEEKSVGEEPQNLHKNRFSDIIALNSCRVMLHKEHADEESDYINAVFLHAHRGRNAFIATQHPLLETVEDFWRMVTD
| ..|.   ||..| |.     . .. ||.| |.| .|||..||. . ..|| |. .  |..|||||| . . .. ...|||||.|| .||||||||| .
ksdftalleefedllsl.....kldtysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyvdgpnlkrkfIatqgPlpntvedFwrmvwe

YDIGTIVMLNNLHELD-QEYPKYWPDHGPTKYGHIGVSVLSKQEQGDVICTKLKVTRKkVRRKTHEVRHLHHVSWPDKCIPEVACSVLDLLDEAQTSQQq
.....||||..| ||. . . .|||. ....||.. | .|| .| .... ..|.|. .    ....|.|.|. .||| ..|.   ..||.|........ 
qgvtvivmLteleelgrekcaqYwplgetltygdftvtllseeelagitlrtlevedl.gdsesrtvthfhytgWpdhgvppspdllldfleavreale.

CGNAPVLVQCSNGVGRSGTFCAISSVLERLKTEQVIDVFQVIKRIRVNLPGAVESPTQYMFCYQIIQKYLD
 .. |||| ||.||||.|||.|.  .||.|..|. .||....|..|   ||||..| ||.|.|.....|| 
dpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalleylk
0047943 (Phosphotyrosine protein) phosphatases II 524-795 5.3e-75 247.7 In-house 5-272 (273) alignment 
Range on Protein: 524-795
Range on HMM: 5-272/273.0
VNRKFQMTGYALEFQRLNSVTSreipAEEKSVGEEPQNLHKNRFSDIIALNSCRVMLhkehADEESDYINAVFLHAHRGRNAFIATQHPLLETVEDFWRM
.......|....||..| |..       ..||.. |.|..|||..||......|| |     |..|||||| ..  ..  ..|||||.|| .||||||||
lekllgltllleefelllslkp....lltysvallpenkdknrykdilpydhsrvkl....gdggsdyinAsyvdgynlkrkfiatqgPlpntvedfwrm

VTDYDIGTIVMLNNLHELDQ-EYPKYWPDHG---PTKYGHIGVSVLSKQEQGDVICTKLKVTRKKVRRkTHEVRHLHHVSWPDKCIPEVACSVLDLLDEA
| .... .||||..|.||..  ...|||. |   ...||.. | .|| .. .|.. ..|..|...    ...|.|.|. .||| ..|.   |.|......
vweqnvrviVmLtelvelgrekcaqYwpleggelsltygkftvtllseetkddytvrtleltnlgtge.srtvthfhytgwpdhgvppslesllefielv

QTSQQQC-GNAPVLVQCSNGVGRSGTFCAISSVLERLKTEQVIDVFQVIKRIRVNLPGAVESPTQYMFCYQIIQKYL
.. .... .| ||.| ||.||||.|||.|.  .|..|..|. .||....|..|   ||.|..| ||.|.|... .||
rkalealpsngpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrflyealleyl
0036941 (Phosphotyrosine protein) phosphatases II 523-796 5.6e-75 247.7 In-house 5-278 (297) alignment 
Range on Protein: 523-796
Range on HMM: 5-278/297.0
SVNRKFQMTGYALEFQRLnsvtSREIPAEEKSVGEEPQNLHKNRFSDIIALNSCRVMLhkehADEESDYINAVFLHAHRGRNAFIATQHPLLETVEDFWR
 ..........  ||..|     . ..  ..||.. |.||.|||..||......|| |     ||.|||||| ..  ..  ..|||||.|| .|||||||
llekllflalllkefeel....lpllllgslsvallpenleknRykdilpydhtRVkl....ddegsdYinAsyvdgydlkrkfIatqgPlpntvedFWr

MVTDYDIGTIVMLNNLHELDQ-EYPKYWPDH--GPTKYGHIGVSVLSKQE--QGDVICTKLKVTRKKVRrKTHEVRHLHHVSWPDKCIPEVACSVLDLLD
|| .... .||||..| ||.   ...|||.   .. .||.. | .|| ..   .|.. ..|.|| ..   ....|.|.|. .||| ..|| . |.||...
mvweqnvtvIvmltelvelgrekcaqywpleegesltygdftvtllsvevvllddytlrtlevtdtgng.esrtvthfhytgwpdhgvpespaslldfie

EAQTSQQQC-GNAPVLVQCSNGVGRSGTFCAISSVLERLK---TEQVIDVFQVIKRIRVNLPGAVESPTQYMFCYQIIQKYLD
.... ...  .. |||| ||.||||||||.|.  .|..|.   .|. .|.....| .|   ||||... ||.|.|......| 
lvrkvlkllpsggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallellk
0039614 (Phosphotyrosine protein) phosphatases II 521-798 1.5e-74 246.5 In-house 22-292 (297) alignment 
Range on Protein: 521-798
Range on HMM: 22-292/297.0
LASVNRKFQMTGYALEFQRLNSVTSreipaEeKSVGEEPQNLHKNRFSDIIALNSCRVMLHKEHA-DEESDYINAVFLHAHRG-RNAFIATQHPLLETVE
|  .......|.. |||..| |..      . .|... |.| .|||..||......|| |. |   |..|||||| ..  ..   ..|||||.|| ||||
llllekansktllllefeellslkp.....d.ysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfIatqgPlpetve

DFWRMVTDYDIGTIVMLNNLHELDQEYPKYWPDHGPtKYGHIGVSVLSKQEQGDVICTKLKVTRkkvRRKTHEVRHLHHVSWPDKCIPEVACSVLDLLDE
|||||| .... .||||..| ||.. ...|||. |  .||.. | .|. .. .... ..|.||.     ....|.|.....||| ..|. . ..|..|..
dFwrmvweqgvtvivmLtklvelgrkcaqywpeegg.tygdftvtllkvehldgytvrtlevtn...ngesrtvthfqytgwpdhgvppslellleflel

AQTSQQQC-GNAPVLVQCSNGVGRSGTFCAISSVLERLKTEQVIDVFQVIKRIRVNLPGAVESPTQYMFCYQIIQKYLDSF
... .... .. |||| ||.||||.|||.|.  .||.|..|. .||....|..|   ||||..| ||.|.|......|  .
vrealaelpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydallellkrk
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 226-506 1e-73 242.7 In-house 2-287 (290) alignment 
Range on Protein: 226-506
Range on HMM: 2-287/290.0
IPIALFPEYVAKMQANGGIRLETEYKKFDNGQ-QFPWEAARKPANKNKNRYANIVAYDHSRVVLERVNGDED--SDYINASFIHGYDGTpRSFIASQGPL
||.  | |.||. .|.|  . ....|..|.|. ..  . .  . ||..||.|||| ||  |..| ...|..|   .||||..|.||    ...|| |||.
ipvdkfgefvanghakgnegfrnqfkmldsgesehtvtvgltssnkllnRfanivvyddnritLrpisghkDCtneyinAcyikgykek.kqyiatqgpv

PPAFEDFWRMVWEQNSQSIVMLTNLVELGKTKCHKYWPDK-TETYGGVTVTLHQSEIFAEYEIRTFILSKAKQ-SGSRMVRQFHFTVWPDKG-VPQYATA
.    |||...|....  |||||| .| ||.||..||||. |..|| ....|.. |.. || .|.. . . ..   ...| |...| |...| |....| 
sntlvdFWkliwqekvtiivmltniieegkvkCqqYWpdsdtkaygefsikllneetlneyierklevknknsagakqsvtqyqitnwdstgkvtnpqti

VLAFRRKVRALNPRDAGPVIVHCSAGVGRTGAYIVIDAMLEQAKKSRTVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVLEALTCGN
.|.... ..    |  ....||||..|||.. .....  ....|.   .|. . |  .|  .| .|||..|| .|.. ||..|.. .
llvieemyktqrkrgntsivvHCSdtvgrsavfcaaattinkcktegvidvfqvlksqRiqkpgsvqtvqqyqgifqivltyldsfe
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 260-500 1.2e-73 242.6 In-house 19-266 (274) alignment 
Range on Protein: 260-500
Range on HMM: 19-266/274.0
PWEAARKPANKNKNRYANIVAYDHSRVVLERVNGDE-DSDYINASFIHGYDGTPRSFIASQGPLPPAFEDFWRMVWEQNSQSIVMLTNLVELGKTKCHKY
. |  . . ...|||| .|.  ..|||.||. .... ||.|||| .|.|||.. . ..| ||||| . .|||||......| |||||.| |  ..||..|
dqeeldvfgsqtknryktilPnensrvllesessededssyinanyikGydeeskayvatqGPlpntvadfWrmiyqeevqvivmltklkeaneqkCavy

WPDKTET-----YGGVTVTLHQSEIFAEYEIRTFILSKAKQsgSRMVRQFHFTVWPDKGVPQYATAVLAFRRKVRALNPR---DAGPVIVHCSAGVGRTG
.||....     ||.| .. ..     .|..|...|.....  .| |  . .| |||. .|. |...| . ..|.  . .    ..||.||||||.||||
fPdaedyeiserygdveikvekiverndysvrklvlkyler..ersvkhywytdWPdhksPddantlldlvleveesreeenaklapvvvhCsaGiGrtG

AYIVIDAMLEQAKKSRTVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVLE
..| |.  . | ... .||. .    || ||  ||||.||| .|| |. .
cfiaisiavrqlreeivvdvlkivcnlrldrGGmvqtseqyelihralcl
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 226-509 1.3e-72 239.3 In-house 2-285 (287) alignment 
Range on Protein: 226-509
Range on HMM: 2-285/287.0
IPIALFPEYVAKMQANGGIRLETEYKKFDNGQQFPWEAARK--PANKNKNRYANIVAYDHSRVVLErvngDEDSDYINASFIHGYDGTpRSFIASQGPLP
||.  | |.||| .|.|    .. .. ... .| . |   .  . ||.|||...|. .|  ||.|.    .|. |||||.|| ||    . ||....|. 
ipvekfgefvakghakgnegfknqftvleqvtqredevthniasqnkdknRltqilvpdnyrvllk....gehpdyinavfidgykek.kafiiaesPmf

PAFEDFWRMVWEQNSQSIVMLTNLVELGKTKCHKYWPDKT-ETYGGVTVTLHQSEIFAEYEIRTFILSKAK-QSGSRMVRQFHFTVWPDKG-VPQYATAV
 .  .||......| . ||||... |  . .|..|||...  ..|  ...| . |. |.| .|.. . . . ..  ..|.|...| |...| |....| .
ntarnfWkliddrnvtaivmlcqekendeevcyqyWpeeksvvlGeyniellneevnagyierklevknknkagdkqqvkqyqitnWdstgkvtepqtil

LAFRRKVRALNPRDAGPVIVHCSAGVGRTGAYIVIDAMLEQAKKSRTVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVLEALTCGNTEI
| . .....   |  ....||||..|||.. .. ..  ....|.  ..|. . |   |  .|..||| ||| ||  .||| |....|  
lvieemyktqrkrgntsivvhCsdtvGrsamfcaaattinkckteGviDvfqvlksqriqkpgsvqtveqykfindivleyldsfetys
0045450 (Phosphotyrosine protein) phosphatases II 529-795 2.1e-72 239.8 In-house 25-304 (307) alignment 
Range on Protein: 529-795
Range on HMM: 25-304/307.0
QMTGYALEFQRLNSVTSREipAEEKSVGEEPQNLHKNRFSDIIALNSCRVMLHKEHAD-EESDYINAVFL--------HAHRGRNAFIATQHPLLETVED
 .||.. ||..|.||| .     | |... |.| .|||..||......|| |. .. . |.|||||| .         . ..  ..|||||.|| |||||
fltgllkefekllsvtvfl..lgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydlkrkfIatqgPlpetved

FWRMVTDYDIGTIVMLNNLHELDQE-YPKYWPDHGPT-KYGHIGVSVLSKQEQGDVICTKLKVTRKKVRRKTHEVRHLHHVSWPDKCIPEVACSVLDLLD
||||. ......||||..| ||..| ...|||| | .  ||.. | .||...........|.||...   ....|.|.|. .||| ..|.   ..||...
FwrmlweqgvtvivmltelvelgrekcaqywPdegeeltygnftvtllseehldgytvrtlevtdldgtgesrtvthfhytgwpdhgvppsfeelldfie

EAQTSQQQC-GNAPVLVQCSNGVGRSGTFCAISSVLERLKTEQV---IDVFQVIKRIRVNLPGAVESPTQYMFCYQIIQKYL
|... .... .. |||| || ||||.|||.|.  .|..|..|..   .|.....|..|   ||||..| ||.|.|......|
evrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyeallell
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 550-798 2.2e-72 238.8 In-house 35-286 (305) alignment 
Range on Protein: 550-798
Range on HMM: 35-286/305.0
AEEKSVGEEPQNLHKNRFSDIIALNSCRVMLHKEHADEESDYINAVFLHAHRGRNAFIATQHPLLETVEDFWRMVTDYDIGTIVMLNNLHELDQEY-PKY
 |   ||.. .| .|||...|. |.  |..| ... ...|||||| ...........|..| || .||.||||.. .. . ||||| .| | ...   .|
eesidvgkkeankaknrlkeitlldddriiltekeslddsdyinasyvdgykrkkkyivaqgPlkntvadfWrliveekvstivmltklveggkdkCrqY

WPDHGPT--KYGHIGVSVLSKQEQGDVICTKLKVTRKKVRRKTHEVRHLHHVSWPDKCIPEVACSVLDLLDEAQTSQQQCGNAPVLVQCSNGVGRSGTFC
||.      ..|.. | . |...  | |  |||.. ..  .... | ...  .|||. .|. | |.|.|... | .|..  . |.|| ||.||||.|.|.
WpesktekkefgefsvelksektasdyieRklkisiededkesrtvlqyqltdWPdhGvpqfatsllslikrvqkdqkkdkgvpllVhCsagvgRtGvfi

AISSVLERLKTEQVIDVFQVIKRIRVNLPGAVESPTQYMFCYQIIQKYLDSF
|..  |||||.|.|.|||.|.|..| . ...|..  ||.|......... ..
avdialerlkkEevvdvfevlkqlRskrmkmvqtldqYvflhdaldelitcg
DSPc_SM00195 536-795 6e-72 237.5 In-house 5-262 (263) alignment 
Range on Protein: 536-795
Range on HMM: 5-262/263.0
EFQRLNSVTSREipaeEKSVGEEPQNLHKNRFSDIIALNSCRVMLHKEHADEESDYINAVFLHAHRGRNAFIATQHPLLETVEDFWRMVTDYDIGTIVML
||..|.. || .    |.. .|...| .|||...|.  .. || |.||. .|.|||||| ..  .. ....||||.|| .|||||||||.. .. .||||
efekleestspk....etteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivml

NNLHEL-DQEYPKYWPDH--GPTKYGHIGVSVLSKQEQG-DVICTKLKVTRKKVrRKTHEVRHLHHVSWPDKCIPEVACSVLDLLDEAQTSQQQCgNAPV
..  |   ..  .|||.   |....|.| | . .....  ..| ..|..| ..  ..|..|..... .|||. .|. . |||.|| ....|...  ..|.
teeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegk.eetrkvtqyqyknWpdhgvpdstksvlellravkksksts.sgpi

LVQCSNGVGRSGTFCAISSVLERLKTEQVIDVFQVIKRIRVNLPGAVESPTQYMFCYQIIQKYL
.|.||.||||.|||..|...|..|..|. .|.|...|..| . ||.|.. .||.|.|..| .|.
vVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi
PTPc_SM00194 536-795 6e-72 237.5 In-house 5-262 (263) alignment 
Range on Protein: 536-795
Range on HMM: 5-262/263.0
EFQRLNSVTSREipaeEKSVGEEPQNLHKNRFSDIIALNSCRVMLHKEHADEESDYINAVFLHAHRGRNAFIATQHPLLETVEDFWRMVTDYDIGTIVML
||..|.. || .    |.. .|...| .|||...|.  .. || |.||. .|.|||||| ..  .. ....||||.|| .|||||||||.. .. .||||
efekleestspk....etteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivml

NNLHEL-DQEYPKYWPDH--GPTKYGHIGVSVLSKQEQG-DVICTKLKVTRKKVrRKTHEVRHLHHVSWPDKCIPEVACSVLDLLDEAQTSQQQCgNAPV
..  |   ..  .|||.   |....|.| | . .....  ..| ..|..| ..  ..|..|..... .|||. .|. . |||.|| ....|...  ..|.
teeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegk.eetrkvtqyqyknWpdhgvpdstksvlellravkksksts.sgpi

LVQCSNGVGRSGTFCAISSVLERLKTEQVIDVFQVIKRIRVNLPGAVESPTQYMFCYQIIQKYL
.|.||.||||.|||..|...|..|..|. .|.|...|..| . ||.|.. .||.|.|..| .|.
vVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi
subfamily_PTPRA_pd Subfamily PTPRA 541-794 8.1e-72 236.9 In-house 39-294 (330) alignment 
Range on Protein: 541-794
Range on HMM: 39-294/330.0
NSVTSREIPAEEKSVgEEPQNLHKNRFSDIIALNSCRVMLHKEHADEESDYINAVFLHAHRGRNAFIATQHPLLETVEDFWRMVTDYDIGTIVMLNNLHE
|.. . .| |  .   .. .| .|||. .|.  .  ||.| . .  |||||||| |.. .. .. |||.| |. |||||||||. ...  ||||| .|.|
nalPagpiqatlela.skeenkeknrvvnilPydfsrvilsvkeGveesdyinasfidGykekdkfiaaqGPkeetvedfwrmiweqksativmltelke

LDQEY-PKYWPDHGPTKYGHIGVSVLSKQEQGDVICTKLKVTR---KKVRRKTHEVRHLHHVSWPDKCIPEVACSVLDLLDEAQTSQQQCGNaPVLVQCS
 ..|   .||||.|   ||.| |.|  ...  |.   |. |..   .. ..|.  || .|  ||||  .|  .  .|.|| . .. .|| .. |. | ||
rkeekcaqywPdeGlvtyGnirvevedetvlvdytvrkflvqqlpdatrekksrlvrqfhftswPdvGvPfepiGmlkllkkvkklnqqsag.pivvhcs

NGVGRSGTFCAISSVLERLKTEQVIDVFQVIKRIRVNLPGAVESPTQYMFCYQIIQKY
 ||||.|||.....||||.|.|...|||...||.| . |  | .  || |.|.....|
aGvGrtGtfivldavlervkaerkvdvfefvkrlrlqrpqmvqtdeqyefiykvlley
subfamily_PTPN3_pd Subfamily PTPN3 259-501 1.5e-71 235.6 In-house 31-274 (280) alignment 
Range on Protein: 259-501
Range on HMM: 31-274/280.0
FPWEAARKPANKNKNRYANIVAYDHSRVVLErvngDEDSDYINASFIHG-YDG--TPRSFIASQGPLPPAFEDFWRMVWEQNSQSIVMLTNLVELGKTKC
   .|||||.| .|||| .|..||. || |.    ....|||||...    ..  .   .||.||||. . .|||.|||||.|. |||||.||| |..||
laisaarkpenlsknryrdilpydatrvklk....esetdyinanyvnmeipstglvnryiatqGPlaktatdfWqmvweqksslivmlttlverGrvkC

HKYWPDKTE--TYGGVTVTLHQSEIFAEYEIRTFILSKAKQSGSRMVRQFHFTVWPDKGVPQYATAVLAFRRKVRALNPRDAGPVIVHCSAGVGRTGAYI
|.|||....  .||. .|......   .| .| ..|...... .|.. |. .. |||.|||. .. .| | ..||.|   .  ||.||||||.|||| .|
hqyWPetedeleygefsvkcekedetksyvlrelvlkdketkeerkilqlqylaWpdhgvPddsadflefvervrklrsgkeePvvvhCsaGigrtGvli

VIDAMLEQAKKSRTVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVLEA
...  |    ... | . . .  .|  |  .|||..|| |.  |.|..
lletalalieaaepvypldivrtmrdqramlvqtasqykfvCeailkv
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 224-525 6.3e-71 233.8 In-house 2-259 (392) alignment 
Range on Protein: 224-525
Range on HMM: 2-259/392.0
KPIPIALFPEYVAKMQANggIRLETEYKKFDNGQQFPWEAARKPANKNKNRYANIVAYDHSRVVLERVNGDEDSDYINASFIHGYDGTpRSFIASQGPLP
.|||.| || .| | . .    .  |.. . . . .|  .|.|. |..|||| ||. || .||.|| ..   ||||.|||.|...|   ...|||||| .
qpipvaqfpafveknrhs..alffeefhdlpgpdiypqtvaqkeinlkknryknilpydsarvkleviddipdsdylnasyipsfdne.kayiasqgpna

PAFEDFWRMVWEQNSQSIVMLTNLVELGktkchkywpdktetyggvtvtlhqseifaeyeirtfilskaKQSGSRMVRQFHFTVWPDKGVPQYATAVLAF
 ...||||||...|  .|.|.|.| |                                           |    | | ||||| ||||.||......| |
aslddfwrmvfqenvttiamvtklkegd.........................................kgddartvaqfhftewPdkdvpkhtssllkf

RRKVRALNPRDAGPVIVHCSAGVGRTGAYIVIDAMLEQAKKSRTVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVLEALTCGNTEIQSENCNQAMQKLAS
 ..|.|   . . |.|.||||||||||  | ||... .|||.| ||. |..  .|. ||.||||||||.||. |||| |   || |      . .|.| .
ikevkadfGqythpliihcsagvgrtgvvisidsvvahakktrmvdvfnfvtnirrkrpymvqtkeqyafiygavledllwrntlipvvhftdhlqdlst

VN
  
ss
0043336 (Phosphotyrosine protein) phosphatases II 526-795 8.9e-71 233.9 In-house 15-277 (278) alignment 
Range on Protein: 526-795
Range on HMM: 15-277/278.0
RKFQMTGYALEFQRLNSVTSreipaEEKSVGEEPQNLHKNRFSDIIALNSCRVMLHKEHADEESDYINAVFLHAHRGRNAFIATQHPLLETVEDFWRMVT
 .   |.. |||..|.|..      ...|... |.| .|||..||......|| |. .  |. |||||| ..  ..  ..|||||.|| |||||||||| 
llnlktllllefeellsfkl.....dtysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyvdgynvprkfiatqgPlpetvedFwrmvw

DYDIGTIVMLNNLHELD-QEYPKYWPdHGPTKYGHIGVSVLSKQEQGDVICTKLKVTRkKVRRKTHEVRHLHHVSWPDKCIPEVACSVLDLLDEAQTSQQ
.... |||||..| ||. . . .|||  |...||.. | .|. ....|.. ..|.||. .   ....|.|.|...||| ..||   ..||.| .... ..
elgvttivmLtelvelgrvkcaqYwp.ggsltygdftvtllkeehlddytvrtlevtn.lgdgesrtvthyhylgwpdhgvpeslsllldflkavreale

qCGNAPVLVQCSNGVGRSGTFCAISSVLERLKTEQVIDVFQVIKRIRVNLPGAVESPTQYMFCYQIIQKYL
   | |||| ||.||||.|||.|.  .||.|..|. .|.....|..|   ||||..| ||.|.|.... ||
.dsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflyealleyl
subfamily_PTPN1_pd Subfamily PTPN1 255-508 2.3e-70 231.6 In-house 18-279 (290) alignment 
Range on Protein: 255-508
Range on HMM: 18-279/290.0
NGQQFPWEAARKPANKNKNRYANIVAYDHSRVVLERvngdEDSDYINASFIHgYDGTPRSFIASQGPLPPAFEDFWRMVWEQNSQSIVMLTNLVELGKTK
. ..|| ..|..|.|.|.||| ..  |||||..|||    .| ||||||...  .   ||.| .||||| . . ||.|||||.|...||| ..|| ...|
easdfptreaklpenrnlnryrdvspydhsrikler....adndyinaslve.leeakrsyiltqGPlpntvdhfWqmvWeqkskavvmlnkvvekeqik

CHKYWPDKTE----TYG--GVTVTLHQSEIFAEYEIRTFILSKAKQSGSRMVRQFHFTVWPDKGVPQYATAVLAFRRKVRAL--NPRDAGPVIVHCSAGV
|..||| . |    ..    ..|.| . |.  .| .|.. | . |   .| . .||.| ||| |||.  .| | |  |||      .| ||...|||||.
caqywPqgeeekellledtklkvkliseerksyytvrllelenlktqetreilhfhyttwpdfgvpespaaflkflfkvresGslssdvGpavihcsaGi

GRTGAYIVIDAMLEQAKKSR---TVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVLEALTC--GNTE
||.|.....|..| . .|.    .|||.. |..||| |  ..||..|  | . |.||   .  |.. 
GrsGtfclvdtclvliekkddlssvdikkvllelrkyrlGliqtadqlrfsylaileGakvikgdss
Y_phosphatase Protein-tyrosine phosphatase 561-792 3.5e-70 231.4 Pfam-A 1-234 (235) alignment 
Range on Protein: 561-792
Range on HMM: 1-234/235.0
NLHKNRFSDIIALNSCRVMLhkEHADEESDYINAVFLHAHRGRNAFIATQHPLLETVEDFWRMVTDYDIGTIVMLNNLHEL-DQEYPKYWP--DHGPTKY
|..|||..||.. .. || |  .. ...|||||| ... ..  ..|||||.|| .|.|||||||..... .||||..| |  ......|||  ......|
nkkknRykdilpydktrvkl..kgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeeslty

GHIGVSVL--SKQEQGDVICTKLKVTRKKVRRKTHEVRHLHHVSWPDKCIPEVACSVLDLLDEAQTSQqQCGNAPVLVQCSNGVGRSGTFCAISSVLERL
|.| | .   .|... ... .||... || .....||..||. .|||...|| . |.|||... ..|. .  ..||.|.||.||||.|||.|.. .||.|
gdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkveksk.eaksgpvvVhCsaGvgRtgtfvaldilleql

KTEQVIDVFQVIKRIRVNLPGAVESPTQYMFCYQIIQ
..|. .||.|..|..| . ||.|.| .||.|.|..|.
eaeeevdvlqivkelRkqRpgmvqsleqYiflykail
Y_phosphatase Protein-tyrosine phosphatase 561-792 3.5e-70 231.4 In-house 1-234 (235) alignment 
Range on Protein: 561-792
Range on HMM: 1-234/235.0
NLHKNRFSDIIALNSCRVMLhkEHADEESDYINAVFLHAHRGRNAFIATQHPLLETVEDFWRMVTDYDIGTIVMLNNLHEL-DQEYPKYWP--DHGPTKY
|..|||..||.. .. || |  .. ...|||||| ... ..  ..|||||.|| .|.|||||||..... .||||..| |  ......|||  ......|
nkkknRykdilpydktrvkl..kgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeeslty

GHIGVSVL--SKQEQGDVICTKLKVTRKKVRRKTHEVRHLHHVSWPDKCIPEVACSVLDLLDEAQTSQqQCGNAPVLVQCSNGVGRSGTFCAISSVLERL
|.| | .   .|... ... .||... || .....||..||. .|||...|| . |.|||... ..|. .  ..||.|.||.||||.|||.|.. .||.|
gdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkveksk.eaksgpvvVhCsaGvgRtgtfvaldilleql

KTEQVIDVFQVIKRIRVNLPGAVESPTQYMFCYQIIQ
..|. .||.|..|..| . ||.|.| .||.|.|..|.
eaeeevdvlqivkelRkqRpgmvqsleqYiflykail
subfamily_PTPN13_pd Subfamily PTPN13 262-503 1.8e-69 229.0 In-house 30-270 (273) alignment 
Range on Protein: 262-503
Range on HMM: 30-270/273.0
EAARKPANKNKNRYANIVAYDHSRVVLERVNGdedsdYINASFIHGYDGTP-RSFIASQGPLPPAFEDFWRMVWEQNSQSIVMLTNLVELGKTKCHKYWP
| ..| .||.|||| |.. ||..|| |.   |     |||||.|.   |    ..||.||||| . .|||.|||||... |.|.|. .| || |||.|||
evgkkkenkdknryrnvlPydetrvklgdegg.....yinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweqkaeviamvtlekekgkvkchrywP

DKTE----TYGGVTVTLHQSEIFAEYEIRTFILSKAKQSGSRMVRQFHFTVWPDKGVPQYATAVLAFRRKVRALNPrDAGPVIVHCSAGVGRTGAYIVID
....     .. ..|.| . .   .. .|.. ... . . || | ...|. ||| |||. |. .| | ..|| |.  ||||..||||||.||.|..|.||
esknkklkvsnrlevellkvqkldgfvvralavkdsesgesrevahlnfvkwPdhgvPssaaellqfvaevrrlqt.dagPivvhcsaGiGrsGtlitid

AMLEQAKKSRTVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVLEALT
..|.  .. . .|... .  ||. |  .||||.|| |.. |.||.|.
vvlglierdkefdvkeivrklreqrqgvvqtkdqyifvykailevlk
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 528-794 1.4e-68 226.0 In-house 18-278 (288) alignment 
Range on Protein: 528-794
Range on HMM: 18-278/288.0
FQMTGYALEFQRLNSVTSReipaEEKSVGEEPQNLHKNRFSDIIALNSCRVMLHKEHADEESDYINAVFLHAHRGRNAFIATQHPLLETVEDFWRMVTDY
 . ||.  |.. | .. .     .....|....| .|||. .|....  || |.| .  ...||||| ... .......|||| || .||.|||..| ..
rnrtgfseeynsLaalekt....ksvtagrlavnakknRyrnilpyDekrvklkkleeeagaDYinasyidgekkkkkyiatqgPladtvndfWelvyen

DIGTIVMLNNLHELD-QEYPKYWPDHGP-TKYGHIGVSVLSKQEQGDVICTKLKVTRKKVRRkthEVRHLHHVSWPDKCIPEVACSVLDLLDEAQTSQQQ
.. |||||..| | . ..  .|||| .  ..||.. | .....|..|..  || . .|| ..   |. .... .|||. .|| .  .|.||.  ....|.
ktstivmltelveggktkCeeYWPdadkpknyGsvtvtlveskeledfvlrklllekkktel...eitqyqylaWpdhgvPeskapllellrqvkvanqa

CgNAPVLVQCSNGVGRSGTFCAISSVLERLKTEQVIDVFQVIKRIRVNLPGAVESPTQYMFCYQIIQKY
    |..|.||.||||.||| |.  .......|..|||. .....| . .  |.  .||.|.|... . 
d.tgpiivhCsaGvGrtgtFialdalidaveeedyiDvagtvaklRkqRallvqtlkqYefiyevllsl
subfamily_PTPRN_pd Subfamily PTPRN 260-501 1.6e-68 225.6 In-house 47-291 (297) alignment 
Range on Protein: 260-501
Range on HMM: 47-291/297.0
PWEAARKPANKNKNRYANIVAYDHSRVVLERVNGDEDSDYINASFIHGYDGTPRSFIASQGPLPPAFEDFWRMVWEQNSQSIVMLTNLVELGKTKCHKYW
  |.|... | .|||......|||||| |.. . .|.|||||||.|   |    ..||.||||.    |||.||||| .  ||.||.| | | ..|..||
tkevakaeknvkknrskavlpydhsrvklkeeasaeksdyinasaildhdprapayiatqgplastvadfwqmvweqGvvvivnltrleeegvkqckryw

PDK-TETYGGVTVTLHQSEIFAE-YEIRTFILSKAKQSGSRMVRQFHFTVWPDKGVPQYATAVLAFRRKVRALNPRDAGPVIVHCSAGVGRTGAYIVIDA
||. .|.|.   | |    |... | .|.| |   ..| .| | ||||  ||..|||  | ..| |||||       . |..||||.|.||||.||.|| 
pdeGsevyhiyevhlvsehiwcddylvrsfylknlqtsetrtvtqfhflswpeegvPasaksllefrrkvnksyrGrscpivvhcsdGaGrtGvyilidl

MLEQAKK-SRTVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVLEA
.|.. .|  . .||   |  || .||..|.||.|. |. .|| | 
vlnrllkGvkeidiaatlehlrdqrpglvktkdqfefaltavaee
subfamily_Ptp69D_pd Subfamily Ptp69D 531-796 4e-68 224.8 In-house 22-287 (307) alignment 
Range on Protein: 531-796
Range on HMM: 22-287/307.0
TGYALEFQRLNSVtsrEIPaEEKSVGEEPQNLHKNRFSDIIALNSCRVMLHKEHADEESDYINAVFLHAHRGRNAFIATQHPLLETVEDFWRMVTDYDIG
 |.| |...|..    ||.  . .|.|.  |. |||. ||.| .. ||.|.|   .|.|||||| |..... .. ||| | |. .|..|||||... .. 
fglakeyekLear...eid.kstkvsekkenalknRyedikafDktRvkLkkingkedsdYinasfikgykekkkfiaaqdPveatigDfWRmiaeqevt

TIVMLNNLHELDQE-YPKYWPDHGPTKYGHIGVSVLSKQEQGDVICTKLKVTRKKV----RRKTHEVRHLHHVSWPDKCIPEVACSVLDLLDEAQTSQQQ
.|||| || | ...  .||||.   ..||.| | . |.....| |  .|.|..||       ....|   |. .|.|  .|||| ..|.|.....  ...
livmlsnlteknrkkcakYWpiedevqygdilvklvseekhsdyiiReldvskkkeesgevedsrkvvqyhytgWkDskvPevargllklieqvrelykl

CgNAPVLVQCSNGVGRSGTFCAISSVLERLKTEQVIDVFQVIKRIRVNLPGAVESPTQYMFCYQIIQKYLD
  ..|..| ||.||||||.| |..|.|..||.|. .|.|...| .| . .  |.|  ||.|.|. . .| .
n.rsPivvhCsaGvgrsgifvaldsllqqlkaedkvdifetvkdLrsqRnllvqsleqYvflyralldyss
subfamily_PTPRK_pd Subfamily PTPRK 555-791 9.9e-68 223.3 In-house 37-273 (314) alignment 
Range on Protein: 555-791
Range on HMM: 37-273/314.0
VGEEPQNLHKNRFSDIIALNSCRVMLHKEHADEESDYINAVFLHAHRGRNAFIATQHPLLETVEDFWRMVTDYDIGTIVMLNNLHELD-QEYPKYWPDHG
.  . .| .|||. ||.| . .||.|.  . | .|||||| .. ...  .|||.||.|| |||.||||.| |..  .||||..| |    .  ||||...
aakkdenreknrsgdilaydrsrvflitidgdpssdyinaalidsykrpaafivtqgPlqetvkdfWrlvydencasivmltelvevgrvkClkyWPedt

PTkYGHIGVSVLSKQEQGDVICTKLKVTR-KKVRRKTHEVRHLHHVSWPDKCIPEVACSVLDLLDEAQTSQQQcGNAPVLVQCSNGVGRSGTFCAISSVL
 . ||.| | ... . . ...   ..|.. ..   ...|||......|||  .|  | ..|.|. . ..||.. .. ...| ||.| ||.|||.||..||
ev.ygdikvelvetellaelvvrifrveklargqeeirevrqfqflgWpdhdvPvsatgllklvrrvkksqee.eaGrivvhCsaGaGrtGtfiaidivl

ERLKTEQVIDVFQVIKRIRVNLPGAVESPTQYMFCYQII
. ...|.|.|||...| .| . .  ||   ||.|.|..|
dmieregvvdvfnavktlrsrkvnmveteeqykfiydvi
0040439 (Phosphotyrosine protein) phosphatases II 553-795 3.1e-67 222.1 In-house 3-246 (249) alignment 
Range on Protein: 553-795
Range on HMM: 3-246/249.0
KSVGEEPQNLHKNRFSDIIALNSCRVMLHKEHADEESDYINAVFLHAHRGRNAFIATQHPLLETVEDFWRMVTDYDIGTIVMLNNLHEL-DQEYPKYWPD
.||.. | |..|||..||......|| |.     . |||||| ...  .  ..|||||.|| |||||||||. ...|..||||..| ||  . . .|||.
ysvallpenkdknrypdilpydhsrvklsilpglflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywpl

HGPTKYGHIGVSVLSKQEQGDVICTKLKVTRKkVRRKTHEVRHLHHVSWPDKCIPEVACSVLDLLDEAQTSQQQC-GNAPVLVQCSNGVGRSGTFCAISS
 |...||.. | .|| .. .|.....|..|..    ....|.|.....|||  .|.   ..||....... ....  . |||| ||.||||.|||.|.  
ggsleygdftvtllsvevkddytvrtleltnl.ydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaayl

VLERLKTEQVIDVFQVIKRIRVNLPGAVESPTQYMFCYQIIQKYL
.||.|..|. .|.....| .|   ||||..| ||.|.|......|
mleqlekelgvdleeavkllrsqRpgavqnpeqyrflyeallell
0042113 (Phosphotyrosine protein) phosphatases II 554-795 5e-67 221.2 In-house 2-243 (245) alignment 
Range on Protein: 554-795
Range on HMM: 2-243/245.0
SVGEEPQNLHKNRFSDIIALNSCRVMLHKEHADEESDYINAVFLHAHRGRNAFIATQHPLLETVEDFWRMVTDYDIGTIVMLNNLHELDQE-YPKYWPDH
||.. | | .|||.|||......|| |  .  |. |||||| . . .|  . |||||.|| |||||||||. ...| |||||....||... ...|||..
svallpenkdknrysdilpydhtrvklspdggdldsdyinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywplg

GPTKYGHIGVSVLSKQEQGDVICTKLKVTRkKVRRKTHEVRHLHHVSWPDKCIPEVACSVLDLLDEAQTSQQQCGNAPVLVQCSNGVGRSGTFCAISSVL
....||.. | .|| .  .|.....|.||. .   ...||.|.|...||| ..|.   ..||.|..... .....| |||| || ||||.|||.|.  .|
esltygdftvtllseehlddytvrtlevtn.lgddesrevihyhylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylml

ERLKTEQVIDVFQVIKRIRVNLPGAVESPTQYMFCYQIIQKYL
|.|..|. .......|..|   ||||..| ||.|.|......|
eqlekelgvsleeavkelrsqRpgavqtpsqyrflyeallell
subfamily_CG7180_pd Subfamily CG7180 264-506 4.2e-66 217.6 In-house 37-294 (296) alignment 
Range on Protein: 264-506
Range on HMM: 37-294/296.0
ARKPANKNKNRYANIVAYDHSRVVLERVNGDEDSDYINASFIHGYDgTPRSFIASQGPLPPAFEDFWRMVWEQNSQSIVMLTNLVELGKtKCHKYWPDK-
. .  |..|||. ..| ||. |||||...|.|.||||||... ..   .. .|  ..|   . ..|||.|........|.||.  .  | ....||| | 
glrkenreknrdvkvvPyDynRvvLekldGeeksdYinavyvdsfl.kkkeyivteapkketvdefWrlvydeeisavvvLtktfdfak.mypsywpnks

TETYGGVTVTLHQSEIFAEYEIRTFILSKA----------KQSGSRMVRQFHFTVWPD-KGVPQYATAVLAFRRKVRALNPRD-----AGPVIVHCSAGV
 | || . | . ... .|. .|||| | |            .   |.|..|..|.|.  . ||  ..|.. .||.|| .  .       |||.|..| |.
keqygeifveiveekqyanlkirtfkltkkivalteqekqvkaetRivklfqlteWeledkvPlstnalielrrrvrlwrekvdedpeegPvvvvssdGa

GRTGAYIVIDAMLEQAKKSRTVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVLEALTCGN
.|.|.|. ||| ||...|   ||. ...  ||..||..|...|.| .|   .|||. |. 
sRsGvylaidanlelvekeeevdvFeavktlrrsRpqLvenveeYkyiYdvlleavlcnk
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 521-803 5.5e-66 217.5 In-house 10-286 (287) alignment 
Range on Protein: 521-803
Range on HMM: 10-286/287.0
LASVNRKFQMTGYALEFQRLNSVTSREipaEEKSVGEEPQNLHKNRFSDIIALNSCRVMLHkehaDEESDYINAVFLHAHRGRNAFIATQHPLLETVEDF
..  ...   .|.   |. |..|| ||   .|  ..  .|| .|||...|.  .  ||.|.    .|. |||||||. ... ..|||... |. .|. .|
fvakghakgnegfknqftvleqvtqre...devthniasqnkdknRltqilvpdnyrvllk....gehpdyinavfidgykekkafiiaesPmfntarnf

WRMVTDYDIGTIVMLNNLHELDQEY-PKYWPDHGPTKYGHIGVSVLSKQEQGDVICTKLKVTRKKVRRKTHEVRHLHHVSWPDKC-IPEVACSVLdLLDE
|... |  . .|||| ...| |.|   .|||..  . .|.  ...|... . ..|  ||.|..|.   ....|.  .  .|...  ..| . ..| ...|
WkliddrnvtaivmlcqekendeevcyqyWpeeksvvlGeyniellneevnagyierklevknknkagdkqqvkqyqitnWdstgkvtepqtill.viee

AQTSQQQCGNAPVLVQCSNGVGRSGTFCAISSVLERLKTEQVIDVFQVIKRIRVNLPGAVESPTQYMFCYQIIQKYLDSFSDYAN
   .|.. ||....| ||..||||..|||.   ... ||| |||||||.|. |.  ||.|   .||.| ..|...|||||. |..
myktqrkrgntsivvhCsdtvGrsamfcaaattinkckteGviDvfqvlksqriqkpgsvqtveqykfindivleyldsfetysd
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 268-513 5.8e-66 217.7 In-house 47-290 (439) alignment 
Range on Protein: 268-513
Range on HMM: 47-290/439.0
ANKNKNRYANIVAYDHSRVVLERVNGDEDSDYINASFIHGYDgTPRSFIASQGPLPPAFEDFWRMVWEQNSQSIVMLTNLVELGKtkchkYWPDKTETY-
 .. |||| ...|.||.||.|. . |   | |||| .|.||  ... .||.|||   . .||||.|.|...  |||||||||  |     ||| ..|.. 
ydqtknrykdvgafdhtrvtlqeipgvphshyinanyikGyy.ddklyiatqgpkkettddfwrlviekktvtivmltnlvesyk.....ywpsdaevcy

GGVTVTLHQSEIFAEYEIRTFILSKAKQS--GSRMVRQFHFTVWPDKGVPQYATAVLAFRRKVRALNP-RDAGPVIVHCSAGVGRTGAYIVIDAMLEQAK
| ..|   .   . .| || | . . ...    | | |||.. |||| ||  |. || | | . . |  .. |||.|||||||||||. | .|  ||| |
gdiavrvdrnielpnyvirgfkvfnerdttekertvlqfhyiawpdknvpaqashvldflrainsandkeeygpvvvhcsagvGrtGtiialdialeqlk

KSRTVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVLEALTCGNTEIQSEN
    |||.  .  |||.| .|||.  || ||. |||| .  |.. .. ..
lenkvdikgivkvlrkqrkqmvqalcqyvfiynavledivyGdiavtide
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 254-500 1e-65 216.4 In-house 5-262 (270) alignment 
Range on Protein: 254-500
Range on HMM: 5-262/270.0
DNGQQFPWEAARKPANKNKNRYANIVAYDHSRVVLERVNGDEDSDYINASFIHGYDGTPRSFIASQGPLPPAFEDFWRMVWEQNSQSIVMLTNLVELGKT
|.... . .      .|. ||||.|.   ..||.||... |. . |||| ...|.|| ....||..|||| . ..||||.||.....|||.|.|.| |..
dkeetsesdlpeaargkklnRyadiLPsPatRvrleeleedsataYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkgrk

KCHKYWPDKTET-----YGGVTVtLHQSEIFAEYEIRTFILSKaKQSGSRMVRQFHFTVWPDKGVPQYAT------AVLAFRRKVRALNPRD--AGPVIV
|| .||| ....     .| ..| | .||  .|  |.| .  . ... .| .  |... |||.|||. .        .|.  |.||. . .   |.|..|
kCerYWpaepkekvkledgkikv.lalseekeegyiltrlrle.ekgeerrlvHfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkaePllv

HCSAGVGRTGAYIVIDAMLEQAKKSRTVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVLE
||||||||||  |..| ...  .... ||. . . .|||||. .||. ||| |.. ||.|
HcsaGvgRtGtlialDiavrlLeetkkvdvlaiieelRkdRmalvqhpeqyeflykavve
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 526-801 7.1e-64 210.5 In-house 15-289 (290) alignment 
Range on Protein: 526-801
Range on HMM: 15-289/290.0
RKFQMTGYALEFQRLNSVTSReipaEEKSVGEEPQNLHKNRFSDIIALNSCRVMLH--KEHADEESDYINAVFLHAHRGRNAFIATQHPLLETVEDFWRM
.. ...|.  .|..|.|  |     ..  ||  ..| ..|||..|.  .  |..|.   .| | . .||||.... .. ....|||| |. .|. |||..
hakgnegfrnqfkmldsgese....htvtvgltssnkllnRfanivvyddnritLrpisghkDCtneyinAcyikgykekkqyiatqgpvsntlvdFWkl

VTDYDIGTIVMLNNLHELDQE-YPKYWPDHGPTKYGHIGVSVLSKQEQGDVICTKLKVTRKKVRRKTHEVRHLHHVSWPDKC-IPEVAcSVLDLLDEAQT
. . ..  |||| |  | ...   .||||.. ..||.. . .|. ..  . | .||.|. |.   ....| ...  .|...  ... . ..| .. | . 
iwqekvtiivmltniieegkvkCqqYWpdsdtkaygefsikllneetlneyierklevknknsagakqsvtqyqitnwdstgkvtnpq.tillvieemyk

SQQQCGNAPVLVQCSNGVGRSGTFCAISSVLERLKTEQVIDVFQVIKRIRVNLPGAVESPTQYMFCYQIIQKYLDSFSDY
 | . || ...| ||..||||..|||.   ... |||.|||||||.|. |.  || |..  || . .||. .|||||. |
tqrkrgntsivvHCSdtvgrsavfcaaattinkcktegvidvfqvlksqRiqkpgsvqtvqqyqgifqivltyldsfety
0045098 (Phosphotyrosine protein) phosphatases II 551-795 3.1e-63 209.1 In-house 23-272 (278) alignment 
Range on Protein: 551-795
Range on HMM: 23-272/278.0
EEKSVGEEPQNLHKNRFSDIIALNSCRVMlhkehadeesDYINAVFLHAHrgRNAFIATQHPLLETVEDFWRMVTDYDIGTIVMLNNLHEL-DQEYPKYW
 | ...  . ||.|||..||......||           ||||| ... .  ...|||||.|| .||.|||||. ...| .||||..|.||  . ...||
seitpalylgnldknRykdilpydhsrVk..........dYINAsyidgy..pkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrekcaqyw

PDHGPTKYGHIGVSVLSKQEQGDVICTKLKVTRK---KVRRKTHEVRHLHHVSWPDKCIPEVA--CSVLDLLDEAQTSQQ------------QCGNAPVL
|..|.  ||.. | .|| .. .|.. ..|.||     .   ....|.||| ..||| ..|.     |.|.||.. .  ..            . .. |||
peggsltygdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsggpvl

VQCSNGVGRSGTFCAISSVLERLktEQVIDVFQVIKRIRVNLPG-AVESPTQYMFCYQIIQKYL
| || ||||.||..|.  .||.|  |...|.....| .|   || ||... ||.|.|. ....|
VHCsaGvgRtGtlvaaylmlell..eggvdlleavkelrsqRpglavqnleqyrflyefllell
subfamily_PTPRB_pd Subfamily PTPRB 529-796 3.3e-63 208.5 In-house 23-286 (293) alignment 
Range on Protein: 529-796
Range on HMM: 23-286/293.0
QMTGYALEFQRLNSVTSREipaeEKSVGEEPQNLHKNRFSDIIALNSCRVMLHKEHADEESDYINAVFLHAHRGRNAFIATQHPLLETVEDFWRMVTDYD
. .... |...|..| . .    .... |...|  |||...|.. .  || |.. . ...|||||| ... .. .. ||||| || |||.|||||| .  
sdlrfseeyeelkavgkdq....avkaaelavnraknrytnilpydhsrvkLaalkdesgsDYinanyipgynsprefiatqGPlpetvddfWrmvwekk

IGTIVMLNNLHELDQ-EYPKYWPDH-GPTKYGHIGVSVLSKQEQGDVICTKLKVTRkkvRRKTHEVRHLHHVSWPDKCIPEVACSVLDLLDEAQTSQ-QQ
  .|||| .| |  .    .|||..  |. ||.| |......|. | .. .||...   ......||..|..||||  .|| . ..||.. . .... ..
ssiivmltqlvekgkvkCeeYWPadeepvlyGdikvtlvaeeeledwvirelkiek...ekeerkvrqyhftsWpdhgvPektktlldfvrtvreaiekt

CGNAPVLVQCSNGVGRSGTFCAISSVLERLKTEQVIDVFQVIKRIRVNLPGAVESPTQYMFCYQIIQKYLD
. ..|..| || ||||.||| |.  .|.....|...|.| .. ..| .    | . .||.| .| ....| 
askrPivvhCsaGvGRtGtfialdrllqaieeedyvdifgivaelReeRnllvqtekqYifihqcvldllr
subfamily_PTPRG_pd Subfamily PTPRG 531-797 3.7e-63 208.6 In-house 19-289 (563) alignment 
Range on Protein: 531-797
Range on HMM: 19-289/563.0
TGYALEFQRL-NSVTSREIPAEEksvGEEPQNLHKNRFSDIIALNSCRVMLHKEHADEES-DYINAVFLHAHRGRNAFIATQHPLLETVEDFWRMVTDYD
.|.. ||. | . ..|....||     ..|.| .||| ..|.| .. || |..    ... ||||| ... ..  .||||||.|| .|..|||||. .  
igfseefealqsetiskdldaeh...sqkpenkrKnRylnivaydrsRvklsplpgkkkklDYinAnyidGyqkskafiatqgplkdtfddFWrmiWeqn

IGTIVMLNNLHEL-DQEYPKYWPDHGPTKYGHIGVSVLSKQEQGDVICTKLKVTR-----KKVRRKTHEVRHLHHVSWPDKCIPEVACSVLDLLDEAQTS
  .|||. || |   .. . |||  .. .||.. |   ...        .|..       || . . ..||. |  .|||.. || .  ||     ....
vaiivmitnlvergrrkcdvYWPkdesetygalqvtlieeevlalytvrtlviknlklkkkkqcdteklvrqyhytkWPdhgvPehslpvLifvkkssaa

QQQcGNAPVLVQCSNGVGRSGTFCAISSVLERLKTEQVIDVFQVIKRIRVNLPGAVESPTQYMFCYQIIQKYLDS
...    |..| ||.||||.||.......|.....|....||...|.|| . .  |..  ||.| ...... . |
nka.eaGPivvHcsaGvgrtGtyivldtllkqiqqenavnvfgflkhiraqRnflvqteEqYiflhdalleaias
subfamily_PTPN12_pd Subfamily PTPN12 531-796 1e-62 206.7 In-house 8-278 (290) alignment 
Range on Protein: 531-796
Range on HMM: 8-278/290.0
TGYALEFQRLNSVTSREIPAE--EKSVGEEPQNLHKNRFSDIIALNSCRVMLHKEHADEESDYINAVFLHAHRGRNAFIATQHPLLETVEDFWRMVTDYD
  .| |||.| .....    .  ....||...| .|||. ||.  .  ||.|.|.. .|.|||||| |..   |. ..||.| || .|..|||||. ...
eefakefqklkklsekykaekvysteagekeenvkknrykDilPydksrvelskieeeegsdYinanfikgvegkleyiaaqgPLpktlddfWrmiwekn

IGTIVMLNNLHELDQE-YPKYWPDHGP--TKYGHIGVSVLSKQEQG-DVICTKLKVTRKkvrRKTHEVRHLHHVSWPDKCIPEVACSVLDLLDEAQTSQQ
.  .||. .. ||..    .|||..|   ...|.. |.. ...    | .   |||...   .....|. .|. .|||. .|. | |.|.|...... |.
veivvmaCrevelgkkkCerYWpeegeeelefgefevtleeekavdddflirtLkveaq...kesrkvyqfhYtaWPDhgvPssaksllelielvrelqe

qCGNAPVLVQCSNGVGRSGTFCAISSVLERLKTEQV---IDVFQVIKRIRVNLPGAVESPTQYMFCYQIIQKYLD
   .||..| || |||| || .||  | | ||.|..   .|||... ..| . . .| .  || . |. . ... 
.sedaPlvvhCsaGvGrtGtiiaidyvrellkaekipeeldvfdlvlelrkqraalvqtkeqyelvykavaelvq
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 553-797 1.9e-62 206.1 In-house 43-286 (297) alignment 
Range on Protein: 553-797
Range on HMM: 43-286/297.0
KSVGEEPQNLHKNRFSDIIALNSCRVMLHKEHADEESDYINAVFLHAHRGrnAFIATQHPLLETVEDFWRMVTDYDIGTIVMLNNLHELDQEYPKYWPDH
. | |.  |..|.|...|.  .| ||.|.    | .|||.|| |... .    .|.|| |  .||.|||.|| |... ||||||...| |..  .||.|.
qtvaekkvnfeksRYkniLPydssRvkLaivnddpdsDyvnasfvkgnkh..rlittqmPmkatvadfWamvldeqvstivmlnddnerdkkcaryWsdk

GPTKYGHIGVSVLSKQEQGDVICTKLKVTRKKVrRKTHEVRHLHHVSWPDKCIPE--VACSVLDLLDEAQTSQQQCGNAPVLVQCSNGVGRSGTFCAISS
| |..|.. | .|| .|.   |  .|.||. |  .... |.  ..|.|||| ...   | |.|.|..| . . .|  ..|.|| |..|||| | ...| |
gvttfGdvsvvllsvsereGfikrelevtkgka.karrvvkqyqfveWPdkaverkdsassllklisevrkdfsqnaegPllvhclaGvGrtgvlltids

VLERLKTEQVIDVFQVIKRIRVNLPGAVESPTQYMFCYQIIQKYLDS
|. . | |. .|.|...|..| . |  |    || | |... ..| |
vvaeakrekevdifglvkklrqerpylvqtkeqykfvyvavlealls
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 555-791 2.3e-62 205.8 In-house 43-275 (315) alignment 
Range on Protein: 555-791
Range on HMM: 43-275/315.0
VGEEPQNLHKNRFSDIIALNSCRVMLHKEHADEESDYINAVFLHAHRGRNAFIATQHPLLETVEDFWRMVTDYDIGTIVMLNNLHELDQEYPK-YWPDHg
|  . .| .|||. .||| .  || |     |..|||.|| |.  .  .. .||.| |. ..|.||||.| ..|||.||||.|| | ...  . ||||. 
vakkienkqknryiniiaydksrvqlpllendphsdyvnanfidGynkkrryiaaqgpnvasvkdfwrlvfeedigkivmltnlvegekrkaekywpdk.

PTKYGHIGVSVLSKQEQGDVICTKLKVTRKKvrrKTHEVRHLHHVSWPDKCIPEVACSVLDLLDEAQTSQQQCGnAPVLVQCSNGVGRSGTFCAISSVLE
   ||.| |.  |.. . .. .  | |. ..   . .||  ||. ||||  .|. . ....|   ..  ...   ....| ||.||||.|||.....||.
kviyGkitvtrkseevnteytvrtlsvvfgd...nirevvqlhytswpdmgvpkytiplmnlirtvkqhhtnsv.gaivvhcsaGvGrtGtfitldavld

RLKTEQVIDVFQVIKRIRVNLPGAVESPTQYMFCYQII
....|..|||...|...| |  ..|..  || | |...
qaeaenaidvynfitgvrqnrikmvqvaeqyqfiydal
subfamily_PTPN23_pd Subfamily PTPN23 243-501 1.4e-61 202.9 In-house 14-279 (288) alignment 
Range on Protein: 243-501
Range on HMM: 14-279/288.0
GIRLETEYKKFDNGQQF-----PWEAARkpANKNKNRYANIVAYDHSRVVLErvngDEDSDYINASFIHGYDGTPRSFIASQGPLPPAFEDFWRMVWEQN
   |....|.... |.         .|.   . .|||. .|. |||.||.|.    ..  |||||||...   .  .|||.|.||...  |||.||.|| 
ktaldkkfkeleqkqdkearkrsiaiak..lyseknrsrdilPyDhnRvklr....gskDDYinAsfvkdlspgcPdfiatqaPlqstlnDFWlmvyeqk

SQSIVMLTNLVELGKTKCHKYWP---DKTETYGGVTVTLHQSEIFAEYEIRTFILSKAKQSGSRMVRQFHFTVWPDKGVPQYATAVLAFRRKVRA----L
|. ||||..  ||||.|...|||   ..|...| ..|||.. .   ..  |...|.  ...  ..|.  ..| ||. |||.    .|.|  .|..     
ssviVmllskeelgkpkvdrYwPedkgetvkfgdlsvtlksvretethvervlkletldadavksvshlqltsWpelGvPasPetllqfldevesayeav

NPRDAGPVIVHCSAGVGRTGAYIVID-AMLEQAKKSRTVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVLEA
. .   |..|||||||||||.. ..  |. |  |.   .|| . .  ||..| .|||.|||. |  .|||||
qrksktPlvvhCsaGvgRtgvfalvyaavrelekgnglldiiqvvsrlreqRrfmvqekeqlkfsyeavlea
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 529-795 5.3e-61 201.5 In-house 21-288 (325) alignment 
Range on Protein: 529-795
Range on HMM: 21-288/325.0
QMTGYALEFQRLNSVTSReipaeEKSVGEEPQNLHKNRFSDIIALNSCRVMLHKEHADEESDYINAVFLHAHRGRNAFIATQHPLLETVEDFWRMVTDYD
.  |.| ||. | |. .       | |   |.|  |||| ...||.  ||.|   . | .|||||| .|. ..... |.|.| || .|..|.||.| |. 
dqdgfahefgllpsddgi.....akkvamkpenkaknrfknvvaldksrvvletkkddpssdyinasylrddkkkdvflaaqaPltatindlWrlvldWr

IGTIVMLNNLHELDQEYPKYWPDH--GPTKYGHIGVSVLSKQEQGDVICTKLKVTRKKvRRKTHEVRHLHHVSWPDKCIPEVACSVLD---LLDEAQTSQ
   .|.|| | . ...  .|||..     ..| . |.. . .|  | .  .|.| . | . .|  |. ... ||.|   ..  ....    |... .   
csvvvvlneldlgkdrcavywpkemgksktfGglevklrtieeisdyvhrvldvkqvk.kGetrsvkqfqlqswddmGvqkrpatlisilqlvkavserv

Q--QCGNAPVLVQCSNGVGRSGTFCAISSVLERLKTEQVIDVFQVIKRIRVNLPGAVESPTQYMFCYQIIQKYL
.    . .|.|| ||.||||.|.| .. |.|... .|  .|.|...|..| . |  ||.  ||...|. . ...
tantkastpilvhcsaGvGrtGvfislysalakvieesrvdifgfvkklrkdrpsmvetvdqyiliyealveay
0037934 (Phosphotyrosine protein) phosphatases II 556-795 3.1e-60 199.1 In-house 5-242 (243) alignment 
Range on Protein: 556-795
Range on HMM: 5-242/243.0
GEEPQNLHKNRFSDIIALNSCRVMLhkehadEESDYINAVFLHAHrGRnaFIATQHPLLETVED----FWRMVTDYDIGTIVMLNNLHEL-DQEYPKYWP
.  |.||.|||.|||....  || |      | |||||| .     .|  .||||.|| |||||    ||||. ...|..||||..| ||  . ...|||
allpenlsknrysdilpydhsrvkl......egsdyinanliyvt.pr..liatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywp

dhGPTKYGHIGVSVLSKQEQGDVICTKLKVTRKKVRRKTHEVRHLHHVSWPDKCIPEVACSVLDLLDEAQTSQQQ-------CGNAPVLVQCSNGVGRSG
  |.. ||.. | .|| .. .|.. ..|......    |..|.|.|...||| ..|.   ..||.|||... ...        .. |||| || ||||.|
..gevtygdftvtllseehlddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRtG

TFCAISSVLERLkteQvIDVFQVIKRIRVNLPG-AVESPTQYMFCYQIIQKYL
|..|.  .|..|   . .|.....|..|   || ||..| ||.|.|......|
tliaaylmllll...g.vdleeavkllreqRpgkavqtpsqyrflyeallell
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 239-508 1.1e-59 196.6 In-house 13-299 (301) alignment 
Range on Protein: 239-508
Range on HMM: 13-299/301.0
QANGgirLETEYKKFDNGQQFPWEAARKPANKNKNRYANIVAYDHSRVVLERVNG--DEDSDYINASFIHGYDGTpRSFIASQGPLPPAFEDFWRMVWEQ
..|.   .| .||. ..|.. . .   . .||. ||. ||. ||. |..|.  .       .|||||.|.||  . . |||.|||.     ||||..|..
hsnk...feeqykelkegedksctvglseenkalnrfknitvyddnriilkpkpnldlcqreyinasyidgysek.kkfiaaqgpmkktlvdfWrliwqe

NSQSIVMLTNLVELGKTKCHKYWPD---KTETYGGVTVTLHQSEIFAEYEIRTFILSKA---------------KQSGSRMVRQFHFTVWPDKGV-PQYA
  .||||.||| |  |.||..|||.   ..|..| .||||... .. .. || . .                  ..  |. | |.. | ||. || ....
kpvsivmvtnlkegtkskceqywpnseaeseefgpftvtlvneqvyPdfvirqlnvkiqdgsnngyierkfkvksdksswdvlqlqvtdWpqdGvvrepr

TAVLAFRRKVRALNPRDAGPVIVHCSAGVGRTGAYIVIDAMLEQAKKSRTVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVLEALTCGNTE
| . .    . . .  . |||.||||..|.|.| |. ..  |||.|    ||. .   |.|. .| .|.| |||..|. .. . |.. .|.
tvLqviddvihrqqkigggpvvVHCSdtVsrsGvYcsvsiglEQckaegVVdvfqvtkavrrskpgaVtTLeqytsiydvidmylqlnsty
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 524-797 1.8e-58 192.8 In-house 8-278 (281) alignment 
Range on Protein: 524-797
Range on HMM: 8-278/281.0
VNRKFQMTGYALEFQRLNSVTSREIpAeekSVGEEPQNLHKNRFSDIIALNSCRVMLHKEHADEESDYINAVFLHAHRGRNAFIATQHPLLETVEDFWRM
 ... . .|.. |.. |...  ..  |   .  ....| .|||.|.|.| .  || ..........||||| |. . .| ...|||| |. .....||.|
qlsqndnaGfieeyeklaaigvdnt.a...taskadenvlknrYsnivaYDatrvkvtpneenkntDYinanfvpgykgekeyiatqgPvPaslvafWqm

VTDYDIGTIVMLNNLHELDQ-EYPKYWPDHG-PTKYGHIGVSVLSKQEQGDVICTKLKVTRKKvrRKTHEVRHLHHVSWPDKCIPEVACSVLDLLDEAQT
| .... .|||. .  | ..    .||||.   .|||.. |. ....|.   |. |.|..|..   .| ||..|....|||. .|. .  .|.  .| . 
vweqkvsaivmvtreieagklkChrYWPddnselkygdvtvkstaeeekatyierkfkleres..getreveqlaytaWPdhGvPattkellefrkevlk

SQQQCGNAPVLVQCSNGVGRSGTFCAISSVLERLKTE-QVIDVFQVIKRIRVNLPGAVESPTQYMFCYQIIQKYLDS
 ...  .||... || ||||.||. |.  .......| . .|| .|.. .| .    | . .|| | |... ..|| 
ltekktkaplvihCsaGvGrtGtyialDrlvkaveaeleeldvkavvaelrkernlmvqtvvqyefvykavldaldk
subfamily_PTPN14_pd Subfamily PTPN14 260-502 2.8e-58 192.3 In-house 40-296 (300) alignment 
Range on Protein: 260-502
Range on HMM: 40-296/300.0
PWEAARKPANKNKNRYANIVAYDHSRVVLERVNgDEDSDYINASFIHGY-DGTPRSFIASQGPLPPAFEDFWRMVWEQNSQSIVMLTNLVELGKTKCHKY
  ..|. | |..|||. ... |...|| |   . .....||||| |.    |. ||.|..||||. . .|||.|||||. | |||||.  | ||.|..||
llstaklpenaeknrfkdvlPyednrvelsptk.enstgyinassikvsvggkersyivaqgPleltvqdfWqmvWeqgvqlivmlteeeedgkeksfky

WPDK-----TETYGGVTVTLHQSEIFAEYEIRTFILSKAKQSGSRMVRQFHFTVWPDKGVPQYATAVLAFRRKVRALNPR---------DAGPVIVHCSA
.|..     | ..|   || . ||    .  ... |     .  | |  . .| |||.|||.  .  | . ..|...  .            ||.|||||
fPkleskkktvefgkfkvttkfsedsdsvittglklkhlpskeertvwhlqytDWpdhgvPeDvkgflsyLeevqsvrrktnseveskeskPPvlvhCsa

GVGRTGAYIVIDAMLEQAKKSRTVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVLEAL
||||||  |. | ...  .. ...||.. |  ||. | ..|||  || |....... |
GvGrtGvlilsdlliatlehneeidikkvlarLreqrmllvqtlaqYkfvYkvlikyl
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 243-499 4.5e-58 191.3 In-house 11-274 (287) alignment 
Range on Protein: 243-499
Range on HMM: 11-274/287.0
GIRLETEYKKFD-NGQQFPWEAARKPANKNKNRYANIVAYDHSRVVLErVNGDEDSDYINASFIHGYDGTpRSFIASQGPLPPAFEDFWRMVWEQNSQSI
 .  | .  | | ..  . . || . |. .|||||... .|..||.|   .|.  |||||| .. .|     .|||.|||.. .  ||||.|.|..| |.
dvdkevdalkedsesstatfkaaeelaavkknryadvlPiddtrvlls.aegelGsdyinanyvasytdd.eafiaaqgPiaatvrdfwravletrsasv

VMLTNLVELGKTKCHKYWPDKTE--TYGGVTVTL-HQSEIFAEYEIRTFILSKAKQSGSRMVRQFHFTVWPDKGVPQYATAVLAFRRKV-----RALNPR
...|  || .. ||.||||..      || .|.|  ..    || .|.. | ...   .|.|.|...  ||||...  | ... |  .|      | .  
itmtreveearlkcykywPerevPmrvGGysvvlldydikePeygvralrlidletrearvvkqldllswPdkvlaPtavglirfvldvkqhielardas

DAGPVIVHCSAGVGRTGAYIVIDAMLEQAKKSRTVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVL
..||..||...|.||.| .. . ..... ..   ||. . .| ||. |  .||.  |. ..  |. 
evGPlvvhddvGiGrsGillatlvlvsrledlGrvdvaavvirlreyraalvqavvqlrllyealv
subfamily_PTPN6_pd Subfamily PTPN6 507-797 9.6e-58 190.6 In-house 2-299 (306) alignment 
Range on Protein: 507-797
Range on HMM: 2-299/306.0
TEIQSENCNQAMQKLASVNRKFQMTGYALEFQRLNSVTSREIpaEEKSVGEEPQNLHKNRFSDIIALNSCRVMLHkEHADEESDYINAVFLH--AHRGRN
|.. ... .| ...|   . ... .|.  ||..|.   ...    ... |. |.| .|||.  |.  .  ||.|. |.   .|||||| ...  ..  ..
tsllakeieqrvselekeeeslekagfeeefeelqqeeakkl..lsrkegakpenkeknryknilPfDhtrvilk.epsvpgsdyinanyikkevkgsdk

AFIATQHPLLETVEDFWRMVTDYDIGTIVMLNNLHELDQ-EYPKYWPDHGP-TKYGHIGVSVLSKQEQGDVICTKLKVTRKKVRRKTHEVRHLHHVSWPD
..||||  | .||.|||||| . .   |||. .  |  .    .||||.   ..||.| |. .|.... | |  .|.|..||  ....||...|. ||||
syiatqgclettvsdFWrmvwqensrvivmttkevErgkekCarYWPdeeekeeyGkisvtnvseksladYilRelsvskkkkkkeerevfqyhfksWPd

KCIPEVACSVLDLLDEAQTSQQQCG---NAPVLVQCSNGVGRSGTFCAISSVLERLKTE---QVIDVFQVIKRIRVNLPGAVESPTQYMFCYQIIQKYLD
. .|.    |||.|.. .. |...    . |..| ||.|.|| |||  |  .|. ....     ||. ...| .|    | |   .|| | |..|.||..
hgvpkdpgavLdfledvnrkqeeleeaeagpivvhCsaGiGRtGtfiviDillkliekkgldadidiqklvksvreqrsglvqteqqykfvykaikkyie

S
.
t
subfamily_PTPN9_pd Subfamily PTPN9 550-794 1.3e-57 190.1 In-house 31-289 (297) alignment 
Range on Protein: 550-794
Range on HMM: 31-289/297.0
AEEKSVGEEPQNLHKNRFSDIIALNSCRVMLHKEHADEESDYINAVFLHAHRGRNAFIATQHPLLETVEDFWRMVTDYDIGTIVMLNNLHELDQ-EYPKY
. .  . . . ||.|||..|.. ... ||.| |.. ||.|||||| |.  .. ..|||||| || .||.|||||| . .. .|||   . |  .    .|
eGtflasklranleknrytdvlcydetrvvlakvdedeasdyinanfvdGykqkkafiatqGplkktvsdfWrmvWeqevlvivmttrvvergrlkcgqy

WP--DHGPTKYGHIGVSVLSKQEQGDVICTKLKVTRKKVrRKTHEVRHLHHVSWPDKCIPEVACSVLDLLDEAQTSQ------------QQCGNAPVLVQ
||  ..  ...|.. ||... .|. |   ..|.... |  ... .| |   .||||  .|. | |.||.|....  |             .. . |..| 
Wpleeessaefgdlsvsnveveeeedykvrvleiknvkt.eesrkvthfqflsWPdyGvPssaaslldvlekvrekqalavkelgdewkghpsgPPivvh

CSNGVGRSGTFCAISSVLERLKTEQVIDVFQVIKRIRVNLPGAVESPTQYMFCYQIIQKY
|| |.||.|||...   |.||......||....|..|     ..  | ||.|||. .  |
csaGiGrtGtfitldiclsrleevgtvdvvetvkllrtqrafsiqtpeqyefcylavley
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 547-796 1.6e-57 189.8 In-house 30-278 (315) alignment 
Range on Protein: 547-796
Range on HMM: 30-278/315.0
EIPAEEKSVGEEPQNLHKNRFSDIIALNSCRVMLHKEHADEESDYINAVFLHAHRGRNAFIATQHPLLETVEDFWRMVTDYDIGTIVMLNNLHELDQ-EY
. .. .. |. |..| .|||. .|. |.| ||.|     . .|||||| ....    .|.||.| ||  .|.|||||| .... ||||.....| |. . 
dPdiyrqrvaretinfkknryknilPldsarvkleviddsPdsdyinasyiksvdddkayiasqgPlkasvddfwrmvlqekvttivmvtkkqegdkikc

PKYWPD--HGPTKYGHIGVSVLSKQEQGDVICTKLkVTRKKvrRKTHEVRHLHHVSWPDKCIPEVACSVLDLLDEAQTSqQQCGNAPVLVQCSNGVGRSG
 .||||     ...| | |..|| . ..| .  || ||||    ... |   .   |||| ... . |.| |. | ... ..  . ..|| || ||||.|
rqywPdrkadsvefGsikvellsleadtdgvarkl.vtrks..eesrtvtqfqftewPdkGvdkqtssllklikevkad.ngkkefsllvhcsaGvGrtG

TFCAISSVLERLKTEQVIDVFQVIKRIRVNLPGAVESPTQYMFCYQIIQKYLD
 ...| .|....| ....|||...| .| . |  | .  .| | |......| 
vvisidevvaqikrtrsvdvfnfvknlrakrpylvqteeeyafiydavledll
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 552-795 2e-57 189.5 In-house 34-276 (515) alignment 
Range on Protein: 552-795
Range on HMM: 34-276/515.0
EKSVGEEPQNLHKNRFSDIIALNSCRVMLHKEHADEESDYINAVFLHAHRGRNAFIATQHPLLETVEDFWRMVTDYDIGTIVMLNNLHELDQE-YPKYWP
 ..| .|  | .|||. .|. ..| || |   . . .|||.|| ....    .|.||.| |.  .|.||||.| .... ||.|...|.| |.    ||||
pqtvaqeeinfkknryknilPydsvrvklevindnPhsdyfnasyipsfdndkayiasqgPnkasvddfWrlvlqenvttiamvtklkegdkikcgkyWP

D--HGPTKYGHIGVSVLSKQEQGDVICTKLKVTRKKvrrKTHEVRHLHHVSWPDKCIPEVACSVLDLLDEAQTSQQQCGnAPVLVQCSNGVGRSGTFCAI
|      |.|.| |...| .  .. |  ||.|.. .   ... |   |   |||| .|. . |.| |. | .....|    |... || |||| | ...|
dkpgdsvkfGsikvelvsleactggikrkltvlkgd...dsrtvtqfhfteWPdkGvpkhtssllklikevkadhgqyt.hpliihcsaGvGrtGvvisi

SSVLERLKTEQVIDVFQVIKRIRVNLPGAVESPTQYMFCYQIIQKYL
 ||. . || ...|||.... || . |  |    || | |.... .|
dsvvahakttrmvdvfnfvtnirqkrpylvqtqeqyafiygavledl
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 530-802 2.6e-57 189.5 In-house 33-299 (319) alignment 
Range on Protein: 530-802
Range on HMM: 33-299/319.0
MTGYALEFQRLnsvTSREIPAEEKSVGEEPQNLHKNRFSDIIALNSCRVMLHKEHADEESDYINAVFLHAHRGRNAFIATQHPLLETVEDFWRMVTDYDI
.| .  ||.|.   . . ..  ...  . .||  |||. .|.| .  .| |..    | |||||| |.  .. .. .||.| || .|..|||||. .|..
ltklevefrra...cklgvnladqtfanldqnkdknriinilafdknvvklerliGeefsdyinasfvtGyqrkdkyiaaqGPldntladfWrmiweync

GTIVMLNnlhelDQEYPKYWPDHGPTKYGHIGVSVLSKQEQGDVICTKLKVTRKKVRRKTHEVRHLHHVSWPDKCIPEVACSVLDLLDE-AQTSQQQCGN
 |||.|       .   .||| ..  |...  |.| | .|  . .  .......   .   ...  |   |||.  |. .  .. |..      ... ..
stivllt.....kdkcsqywplkivikeerfkvkvdsveetaeyvvrdielsedgkekdirkitqfhflGwpdvGvpdypsdlmrlvkkvrhltskenhr

APVLVQCSNGVGRSGTFCAISSVLERLKTEQVIDVFQVIKRIRVNLPGAVESPTQYMFCYQIIQ-KYLDSFSDYA
|...| || ||||.|.. ..  .|.|.| |. .||..... .| . .  |.. .||.|.|  .  ..| ..|| |
anivvhcsaGvGrtGvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalleehlfghsdva
subfamily_PTPRD_pd Subfamily PTPRD 644-802 5.9e-57 188.6 In-house 132-288 (564) alignment 
Range on Protein: 644-802
Range on HMM: 132-288/564.0
EYPKYWPDHGPTKYGHIGVSVLSKQEQGDVICTKLKVtRKKVRRKTHEVRHLHHVSWPDKCIPEVACSVLDLLDEAQTSQqQCGNAPVLVQCSNGVGRSG
.. ||||..|...||.. |.. ...|  |......|. .|| .....|||. |..||||...|| |.|.|||... .... .... |..|.||.||||.|
kchkYWPekgtetygeltVtleeeeeladyeirtfkl.kkkkssesreVrqFhFtsWPdhgvpesatslLdlirkvraln.epdagPivVhCSaGVGRTG

TFCAISSVLERLKTEQVIDVFQVIKRIRVNLPGAVESPTQYMFCYQIIQKYLDSFSDYA
||..|...|||.|.|...|..|..|..| . .  |....||.|....|...|.....  
tfividamlerikeektvDiyqyvkalrkqRnamVqteeQYiFiheailealacgntev
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 263-511 1.4e-56 186.5 In-house 27-275 (283) alignment 
Range on Protein: 263-511
Range on HMM: 27-275/283.0
AARKPANKNKNRYANIVAYDHSRVVLERVNGdedsDYINASFIH--GYDGTPRSFIASQGPLPPAFEDFWRMVWEQNSQSIVMLTNLVELGKTKCHKYWP
 |    ||.|||. .||..|  || |.  .     |||||.||     .   . .|..|.||  .  |||.||....  .|||||.| |  . || .|||
iasadenkrknrnqeivpadqwrvelksesr....dyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfdekitaivmltklqedlrikCsqyWP

DK-TETYGGVTVTLHQSEIFAEYEIRTFILSKAKQSGSRM-VRQFHFTVWPDKGVPQYATAVLAFRRKVRALNPRDAGPVIVHCSAGVGRTGAYIVIDAM
 . .| ||  ||||..      . |. ..| .   . | . .  . .  | . |      ... | . .   .    ||..||||.|.|||...| . | 
krGsedyGeftvtlrkettsnsfiikelllrvnssakstlllahyqvidWleygeqaiinslvkfnkvislqteskkgPivvhCstgiGrtavfiaasas

LEQAKKSRTVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVLEALTCGNTEIQS
...|. .  ||. . .  .|..|. .|||..|| ..| .|||   ||.|.|  
vkdaltesvvdvfavvkimreqrmmavqtldqyklvhelvleqalcgdtqiaa
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 545-802 2.1e-56 186.5 In-house 9-263 (284) alignment 
Range on Protein: 545-802
Range on HMM: 9-263/284.0
SREIPAEEKSVGEEPQNLHKNRFSDIIALNSCRVMLHKEHADEESDYINAVFLHAHRGRNAFIATQHPLLETVEDFWRMVTDYDIGTIVMLNnlhelDQE
 . ... ...  . .||  |||. .|.| .  .| |..    | |||||| |.  .. .. .|||| || .|..|||||. .|.. |||.|      .. 
klgvngtdqtfanldqnkdknrighilafdknvvklerliGeefsdyinasfitGyqrkdkyiatqGPldntladfWrmiweyncstivllt.....kdk

YPKYWPDHGPTKYGHIGVSVLSKQEQGDVICTKLKVTRKKVRRKTHEVRHLHHVSWPDKCIPEVACSVLDLLDE-AQTSQQQCGNAPVLVQCSNGVGRSG
  .||| ..  |...  |.| | .|  . .  .......   ..  ..|  |   |||.  |. .  .. |..     .... ..|...| || ||||.|
csqywplkivikeerfkvkvdsveeseeyvvrdielsedgkekdirkirqfhflgwpdvgvpdypsdlmrlvkkvrhltskenhranivvhcsagvgrtg

TFCAISSVLERLKTEQVIDVFQVIKRIRVNLPGAVESPTQYMFCYQIIQ-KYLDSFSDYA
.. ..  .|.|.| |. .||..... .| . .  |.. .||.|.|  .  ..| ..|| |
vyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalleehlfghsdva
subfamily_CG7180_pd Subfamily CG7180 529-795 8.3e-55 180.5 In-house 11-290 (296) alignment 
Range on Protein: 529-795
Range on HMM: 11-290/296.0
QMTGYALEFQRLNSVTSReIPAEEKSVGEEPQNLHKNRFSDIIALNSCRVMLHKEHADEESDYINAVFLHAHRGRNAFIATQHPLLETVEDFWRMVTDYD
..  . .|.. .  .|.| .  ..   | . .|. |||  ...  .  ||.|.| . .|.|||||||.  ..   ...| |. |  |||..|||.| | .
krrkfrveyklelkltpr.leigdCagglrkenreknrdvkvvPyDynRvvLekldGeeksdYinavyvdsflkkkeyivteapkketvdefWrlvydee

IGTIVMLNNLHELDQEYPKYWPDHGPTKYGHIGVSVLSKQEQGDVICTKLKVTRK---------KVRRKTHEVRHLHHVSWPD-KCIPEVACSVLDLLDE
| ..|.| .  .  . ||.||| .. ..||.| | ......  ..   ..|.|.|         .|  .|  |....   |.  . .| .. ....|.  
isavvvLtktfdfakmypsywpnkskeqygeifveiveekqyanlkirtfkltkkivalteqekqvkaetRivklfqlteWeledkvPlstnalielrrr

AQTSQQQC----GNAPVLVQCSNGVGRSGTFCAISSVLERLKTEQVIDVFQVIKRIRVNLPGAVESPTQYMFCYQIIQKYL
... ...      ..||.| .|.|..||| ..||   || .. |. .|||. .|..| . |. ||. ..|...|.......
vrlwrekvdedpeegPvvvvssdGasRsGvylaidanlelvekeeevdvFeavktlrrsRpqLvenveeYkyiYdvlleav
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 559-796 4.2e-54 178.5 In-house 26-269 (274) alignment 
Range on Protein: 559-796
Range on HMM: 26-269/274.0
PQNLHKNRFSDIIALNSCRVMLHKEHADEE-SDYINAVFLHAHRG-RNAFIATQHPLLETVEDFWRMVTDYDIGTIVMLNNLHELDQ-EYPKYWPDHGPT
. . .|||. .|.  .  ||.|..|....| |.|||| ...  ..  .|..||| || .||.|||||.   ..  |||| .|.| ..    .|.||.  .
fgsqtknryktilPnensrvllesessededssyinanyikGydeeskayvatqGPlpntvadfWrmiyqeevqvivmltklkeaneqkCavyfPdaedy

----KYGHIGVSVLSKQEQGDVICTKLKVTRKKVrrkTHEVRHLHHVSWPDKCIPEVACSVLDLLDEAQTSQQQCG--NAPVLVQCSNGVGRSGTFCAIS
    .||.. . | .. |. |   .|| .   .    ...| |  . .|||.  |. | ..|||..| ..|...     |||.| || |.|| | | |||
eiserygdveikvekiverndysvrklvlkyler...ersvkhywytdWPdhksPddantlldlvleveesreeenaklapvvvhCsaGiGrtGcfiais

SVLERLKTEQVIDVFQVIKRIRVNLPGAVESPTQYMFCYQIIQKYLD
  . .|. |.|.||....  .|..  | |..  || . .... .|| 
iavrqlreeivvdvlkivcnlrldrGGmvqtseqyelihralclylk
0051429 (Phosphotyrosine protein) phosphatases II 297-520 5.9e-54 178.8 In-house 4-242 (272) alignment 
Range on Protein: 297-520
Range on HMM: 4-242/272.0
SDYINASFIHGYdGT---PRSFIASQGPLPPAFEDFWRMvWEQNSQSIVMLTNLVELGKTKCHKYWP-------------DKTETYGGVTVTLHQSEIFA
|.||||... || |    |. ...|.||||   .||||. .|..  .||.|....|.|. ||..|||             . | .|| ..|||.. |.. 
sgyiNardvggy.grvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseelll

EYEIRTFILSKA-KQSGSRMVRQFHFTVWPDKGVPQYAtaVLAFRRKVRAlnprdAGPVIVHCSAGVGRTGAYIVIDAMLEQAKKSRTVD--------IR
 | .|...|..  . . .|.|...|.| ||| |||| |  .|.. . ...      |||.||||||..||| ..... .|..  ..  ||        ..
dyilrellltlllsagearevmhlhytdwpdhgvpqea..llellellld.....ggpvlvHCsaGkdRTGtvvallllllgvsletivddYlltnlyle

NYLIALRKDRPHMVQTKEQYSFIHSAVLEAlTCGNTEIQSENCNQAMQK
...  ||. ||..||| ||| |.. |.||.  .. .... |  ..|.. 
eaveelraqrpgavqteeqylflyeallel.lrsllsvraeyllaalda
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 551-803 7.5e-53 174.2 In-house 30-301 (301) alignment 
Range on Protein: 551-803
Range on HMM: 30-301/301.0
EEKSVGEEPQNLHKNRFSDIIALNSCRVMLHKEHA--DEESDYINAVFLHAHRGRNAFIATQHPLLETVEDFWRMVTDYDIGTIVMLNNLHEL-DQEYPK
.. .|| . .| . ||| .|  ..  |..|.....    . .|||| .... . ...|||.| |. .|. ||||.. ..   .|||. ||.|   ..  .
ksctvglseenkalnrfknitvyddnriilkpkpnldlcqreyinasyidgysekkkfiaaqgpmkktlvdfWrliwqekpvsivmvtnlkegtkskceq

YWPDHGPTKY--GHIGVSVLSKQEQGDVICTKLKVTRK--------------KVRRKTHEVRHLHHVSWPDKCIPEVACSVLDLLDEAQTSQQQCGNAPV
|||.   ...  |.. | . ..|   | .  .|.|. .              | ......|  |. ..||.  .      ||  .|.    ||. | .||
ywpnseaeseefgpftvtlvneqvyPdfvirqlnvkiqdgsnngyierkfkvksdksswdvlqlqvtdWpqdGvvreprtvLqviddvihrqqkigggpv

LVQCSNGVGRSGTFCAISSVLERLKTEQVIDVFQVIKRIRVNLPGAVESPTQYMFCYQIIQKYLDSFSDYAN
.| ||..|.|||..|..|  ||  | | |.|||||.|..| . ||||    ||.. |..|..||   | |||
vVHCSdtVsrsGvYcsvsiglEQckaegVVdvfqvtkavrrskpgaVtTLeqytsiydvidmylqlnstyan
subfamily_PTPN23_pd Subfamily PTPN23 530-795 1.9e-51 169.6 In-house 14-280 (288) alignment 
Range on Protein: 530-795
Range on HMM: 14-280/288.0
MTGYALEFQRLNSVTSREipAEEKSVGEEPQNLHKNRFSDIIALNSCRVMLHkehaDEESDYINAVFLHAH-RGRNAFIATQHPLLETVEDFWRMVTDYD
 |.   .|. |..   .|  |...|.     . .|||. ||.  .. ||.|.    ... ||||| |..    |   ||||| || .|. |||.|| .  
ktaldkkfkeleqkqdke..arkrsiaiaklyseknrsrdilPyDhnRvklr....gskDDYinAsfvkdlspgcPdfiatqaPlqstlnDFWlmvyeqk

IGTIVMLNNLHELDQE-YPKYWPDH--GPTKYGHIGVSVLSKQEQGDVICTKLKVTRKKVRrKTHEVRHLHHVSWPDKCIPEVACSVLDLLDEAQT---S
  .|||| . .||...   .||| .   ..|.|.. |.. |..| . ..  .||.. .... ....|.||.  |||.  .|.   ..|..|||...   .
ssviVmllskeelgkpkvdrYwPedkgetvkfgdlsvtlksvretethvervlkletldad.avksvshlqltsWpelGvPasPetllqfldevesayea

QQQCGNAPVLVQCSNGVGRSGTFCAISSVLERLKTE-QVIDVFQVIKRIRVNLPGAVESPTQYMFCYQIIQKYL
.|.  ..|..|.|| ||||.|.|. . .... |...  ..|. ||..|.| .    |.  .|. |.|... .. 
vqrksktPlvvhCsaGvgRtgvfalvyaavrelekgnglldiiqvvsrlreqRrfmvqekeqlkfsyeavleaa
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 531-791 1.9e-51 169.7 In-house 6-262 (283) alignment 
Range on Protein: 531-791
Range on HMM: 6-262/283.0
TGYALEFQRLNSVTsreIPAEEKSVGEEPQNLHKNRFSDIIALNSCRVMLHKEHAdeesDYINAVFLH---AHRGRNAFIATQHPLLETVEDFWRMVTDY
... | ...|. ..   .|  .  .    .| .|||. .|.. .  || |. |      |||||||.     ..  . .|..| || .|| |||.|| | 
nnnklfrevlkrls...vpdldadiasadenkrknrnqeivpadqwrvelksesr....dyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfde

DIGTIVMLNNLHEL-DQEYPKYWPDHGPTKYGHIGVSVLSKQEQGDVICTKLKVTRKKVRRKTHEVRHLHHVSWpDKCIPEVACSVLDLLDEAQTSQQQC
.| .|||| .| |  ...  .||| .|  .||   |..     .   |  .| .  .   ..|  . |   . |  .. ..     |  ..  .. |.. 
kitaivmltklqedlrikCsqyWPkrGsedyGeftvtlrkettsnsfiikelllrvnssakstlllahyqvidW.leygeqaiinslvkfnkvislqtes

GNAPVLVQCSNGVGRSGTFCAISSVLERLKTEQVIDVFQVIKRIRVNLPGAVESPTQYMFCYQII
 ..|..| ||.|.||...|.|.|. .. ..|| |.|||.|.| .|.....|| .  ||.. ....
kkgPivvhCstgiGrtavfiaasasvkdaltesvvdvfavvkimreqrmmavqtldqyklvhelv
0041856 (Phosphotyrosine protein) phosphatases II 269-508 2.4e-51 169.2 In-house 1-177 (182) alignment 
Range on Protein: 269-508
Range on HMM: 1-177/182.0
NKNKNRYANIVAYDHSRvvlervngdeDSDYINASFIHGYDGTPRsFIASQGPLPPAFEDFWRMVWEQNSQSIVMLTnlvelgktkCHKYWPDKTetygg
|..|||| .|. |||||          |.|||||... |.  . | ||| ||||.  ..||.||..|.. ..||.||         .. |||..      
nldknrysdilpydhsr..........dldyInanlylgslpatr.fiatqgpllstvadflrmlkelgittivnlt.........eelywpell.....

vtvtlhqseifaeyeirtfilskakqsgSRMVRQFHFTVWPDKGVPQyATAVLAFRRKVRAlnprDAGPVIVHCSAGVGRTGAYIVIDAMLEQakksrTV
                             |.. |.... ||| |||     .|.| ..|..    . |||.|||||||||||...... |...      |
............................erlgiqylylpwpDhgvpd.ldelldfieevle....eggpvlVHCsaGvgRtgtlvaaylmkkl.....gv

DIRNYLIALRKDRPHMVQTKEQYSFIHSAVLEALTCGNTE
.... .  .|. ||.||.| .|| |.. |.|| | ...|.
sleeavklvrsrRpgmvitpnqyfflqlallellllkktr
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 551-796 1.1e-48 160.6 In-house 10-265 (270) alignment 
Range on Protein: 551-796
Range on HMM: 10-265/270.0
EEKSVGEEPQNLHKNRFSDIIALNSCRVMLHKEHADEESDYINAVFLH-AHRGRNAFIATQHPLLETVEDFWRMVTDYDIGTIVMLNNLHELDQEY-PKY
.|... |  .. . ||. ||.     ||.|.... |... |||| ... ..  ....||.. ||  |...||||. .    .|||. .|.|  ..   .|
sesdlpeaargkklnRyadiLPsPatRvrleeleedsataYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkgrkkCerY

WPDHGPT----KYGHIGVSVLSKQEQGDVICTKLKVTRKKvrrKTHEVRHLHHVSWPDKCIPEVAC------SVLDLLDEAQTSQQQCGNA-PVLVQCSN
|| .  .    ..|.| | .||.. .   | |.|....|    ..... | ....|||. .|. .       ..| .| . . |...  .| |.|| ||.
Wpaepkekvkledgkikvlalseekeegyiltrlrleekg...eerrlvHfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkaePllvHcsa

GVGRSGTFCAISSVLERLKTEQVIDVFQVIKRIRVNLPGAVESPTQYMFCYQIIQKYLD
||||.||. |.  ... |.... .|| ..|...| . .  |. | || | |. ...| .
GvgRtGtlialDiavrlLeetkkvdvlaiieelRkdRmalvqhpeqyeflykavveyae
subfamily_PTPN3_pd Subfamily PTPN3 547-796 1.7e-46 153.4 In-house 27-277 (280) alignment 
Range on Protein: 547-796
Range on HMM: 27-277/280.0
EIPAEEKSVGEEPQNLHKNRFSDIIALNSCRVMLHKEhadeESDYINAVFLHAHR----GRNAFIATQHPLLETVEDFWRMVTDYDIGTIVMLNNLHELD
  |  . |.   |.||.|||. ||.. .. ||.|...    |.||||| ..          | .|||| || .|..|||.|| . .. .|||| .| |  
kkpglaisaarkpenlsknryrdilpydatrvklkes....etdyinanyvnmeipstglvnryiatqGPlaktatdfWqmvweqksslivmlttlverG

-QEYPKYWPDHGP-TKYGHIGVSVLSKQEQGDVICTKLKVTRKKVRrKTHEVRHLHHVSWPDKCIPEVACSVLDLLDEAQTSQqQCGNAPVLVQCSNGVG
 .   .|||...  ..||.. | . ...|.  ..  .| ...|. . . ... .| ...|||...|. . ..|..... .. . .  . ||.| || |.|
rvkChqyWPetedeleygefsvkcekedetksyvlrelvlkdketk.eerkilqlqylaWpdhgvPddsadflefvervrklr.sgkeePvvvhCsaGig

RSGTFCAISSVLERLKTEQVIDVFQVIKRIRVNLPGAVESPTQYMF-CYQIIQKYLD
|.| . ..   |  . ... . . ......|      |....|| | |  |.. | .
rtGvlilletalalieaaepvypldivrtmrdqramlvqtasqykfvCeailkvyee
0036282 (Phosphotyrosine protein) phosphatases II 297-495 2.7e-46 152.8 In-house 2-163 (174) alignment 
Range on Protein: 297-495
Range on HMM: 2-163/174.0
SDYINASFIHGYDGTPrSFIASQGPLPpafedFWRMVWEQNSQSIVMLTNLVELGKTKCHKYWPDktetyggvtvtlhqseifaeyeirtfilskAKQSG
|||||||.....  ||  .||.||||.     ||.|..|......|||....|||..||. |||.                               ... 
sdyinaspldlsyitp.rliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe..............................lredl

SRMVRQFHFTVWPDKGVPQYATaVLAFRRKVRALNPR-DAGPVIVHCSAGVGRTGAYIVIDAMLEQAKkSRTVDIRNYLIALRKDRPHMVQTKEQYSFIH
.|.. |.... ||| |||  .. .| | . |.    . . |||.|||||||||||. .... || . . ...||. ... .||. ||.|||| .|| |..
erlgiqylylpwpDhgvpdlsi.llefvkfveealsedpggpvlVHCsaGvgRtGtlvaaylmlrgll.eslvdaldlvrelRlqrpgmvqtpsQyrfly
0051429 (Phosphotyrosine protein) phosphatases II 589-798 3.3e-46 153.4 In-house 4-228 (272) alignment 
Range on Protein: 589-798
Range on HMM: 4-228/272.0
SDYINAVFLHAHRG---RNAFIATQHPLLETVEDFWRMvTDYDIGTIVMLNNLHELDQEY-PKYWP------------DHGPTKYGHIGVSVLSKQEQGD
|.|||| ..    .   .........||  |..||||.  ...| |||.| ...|....  ..|||            .. .  ||.. | .||.. . |
sgyiNardvggygrvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseellld

VICTKLKVTRKKVRRKTHEVRHLHHVSWPDKCIP-EVACSVLDLLDEaqtsqqqcgNAPVLVQCSNGVGRSGTFCAISSVLERLKTEQVID--------V
.|...| .|..    ...||.|||. .||| ..| |  ...|.|| .         . |||| || |..|.||..|.  .|...  |...|        .
yilrellltlllsagearevmhlhytdwpdhgvpqeallellellld.........ggpvlvHCsaGkdRTGtvvallllllgvsletivddYlltnlyl

FQVIKRIRVNLPGAVESPTQYMFCYQIIQKYLDSF
.......|   ||||....||.|.|......|.|.
eeaveelraqrpgavqteeqylflyeallellrsl
subfamily_PTPN13_pd Subfamily PTPN13 531-796 6.3e-46 151.8 In-house 11-270 (273) alignment 
Range on Protein: 531-796
Range on HMM: 11-270/273.0
TGYALEFQRLNSVTsreiPAEEKSVGEEPQNLHKNRFSDIIALNSCRVMLHKEHAdeesdYINAVFLHAHRGRNAF--IATQHPLLETVEDFWRMVTDYD
   | ||. |. .     | .. .||.. .| .|||. ...  .  || | .| .     |||| ..... | . .  ||.| || |||.|||.|| . .
qqPaeefkelrelk....pldtcevgkkkenkdknryrnvlPydetrvklgdegg.....yinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweqk

IGTIVMLNNLHELDQ-EYPKYWPDHGPTK---YGHIGVSVLSKQEQGDVICTKLKVTRKKVrRKTHEVRHLHHVSWPDKCIPEVACSVLDLLDEAQTSQQ
   |.|. .  | ..    .|||..   |   .. . |..|  |.. .    .|.|. ..  ....|| ||. |.|||  .|  | ..| .. | .. |.
aeviamvtlekekgkvkchrywPesknkklkvsnrlevellkvqkldgfvvralavkdses.gesrevahlnfvkwPdhgvPssaaellqfvaevrrlqt

qcGNAPVLVQCSNGVGRSGTFCAISSVLERLKTEQVIDVFQVIKRIRVNLPGAVESPTQYMFCYQIIQKYLD
   ..|..| || |.|||||. .|  ||. .. .. .|| ......|    | | .  ||.|.|..| . | 
..dagPivvhcsaGiGrsGtlitidvvlglierdkefdvkeivrklreqrqgvvqtkdqyifvykailevlk
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 253-500 9.3e-46 150.8 In-house 40-281 (290) alignment 
Range on Protein: 253-500
Range on HMM: 40-281/290.0
FDNGQQFPWEAARKPANKNKNRYANIVAYDHSRVVLErvNGdEDSDYINASFIHGydgTPRSFIASQGPLPPAFEDFWRMVWEQNSQSIVMLTNLVELGK
.  .|..  .   | .. .|||| ..|  | .||.|.  .|  | ||. | ...|   .   || .||.|  .  |.|||| ...   |||| .|.| ||
ylpvqylerkifdkntefkknrykdvvcndktrvilk..dG.ydGdyvhanyvkG...lkamfiltqGalkdtvidiwrmvlqekvaaivmlceliedGk

TKCHKYWPDKT---ETYGGVTVTLHQSEIFAEY-EIRTFILSKAKQSGSRMVRQFHFTVWPDKGVPQYATAVLAFRRKVRALnprdAGPVIVHCSAGVGR
.||..|.|.|     |.| .||.  ...   .    .|. . . ..  . ... ..   |||| |.. . |.|   | .| .    .|||.||||||.||
akceqyypekeGevltfGeitvlcseeddkdaniikktlsvrdkdsGkehklkhlkikswpdksvalstlallrtlrilrka....sGpvvvhcsaGiGr

TGAYIVIDAMLEQAKKSRTVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVLE
||... |.. |.   . . .|. .   |||. |   ||   ||  .  ..|.
tGtfvaievglqilldGkeldlldlvralrnsrlnsvqvdiqylalveilld
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 244-501 5.5e-44 145.4 In-house 16-276 (307) alignment 
Range on Protein: 244-501
Range on HMM: 16-276/307.0
IRLETEYKKFDNGQQFPWEAARKPANKNKNRYANIVAYDHSRVVLErVNGdEDSDYINASFIhGYDGTPRSFIASQGPLPPAFEDFWRMVWEQNSQSIVM
 .|  |.... . .     .    || .|||| .. . |..|.|.. ..|   |||| | .. |    |. ||..||||  .  .|| |. ... .|..|
qalvdefrvlakktpegvtveafsantdknryqdvkcqdkgrivvk.fdg.lasdyihanyl.giaikpkkficaqgplentqysfwamaiqekvesvim

LTNLVELGKTKCHKYWPD---KTETYGGVTVTLHQSEIFA------EYEIRTFILSKAKQSGSRMVRQFHFTVWPDKGVPQYATAVLAFrrkVRALNpRD
| ...||.| ||..|||    .. ..|  . |.  ... |      |  |    |     ..|| .... .. |||.||||   . . .   . | .  |
lckvielakikceqywpleegqklvfgeapntisvanlgakklapdedlinvttlkvdwaqksrtiqhlqwenwpdrgvpqinltainl...leavr.yd

AGPVIVHCSAGVGRTGAYIVIDAMLEQAKKS-RTVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVLEA
  ||.|||||||||.|. . |  . ..  .     |... .  ||..|.. .||. || ..|  .|| 
tnpvvvhcsaGvGrsGtivaislvqdkmiaGinckdmkklveelrsqrhyaiqteaqylylhrvlley
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 554-793 7.8e-44 144.8 In-house 41-277 (439) alignment 
Range on Protein: 554-793
Range on HMM: 41-277/439.0
SVGEEPQNLHKNRFSDIIALNSCRVMLHKEHADEESDYINAVFLHAHRGRNAFIATQHPLLETVEDFWRMVTDYDIGTIVMLNNLHELDQeypkYWPDHG
|.  .  .  |||. |. |..  ||.|..      | |||| ... .   . .|||| |  ||..||||.| .    ||||| || |  .    |||  .
slaaqeydqtknrykdvgafdhtrvtlqeipgvphshyinanyikGyyddklyiatqgpkkettddfwrlviekktvtivmltnlvesyk....ywpsda

PTKYGHIGVSVLSKQEQGDVICTKLKVTRKKVR-RKTHEVRHLHHVSWPDKCIPEVACSVLDLLDEAQTSQQQCGNAPVLVQCSNGVGRSGTFCAISSVL
 . || | | |  . |  . .   .||  .. . .| . | ..|...|||| .|  |  |||.|   ......    ||.|.|| ||||.||  |.   |
evcygdiavrvdrnielpnyvirgfkvfnerdttekertvlqfhyiawpdknvpaqashvldflrainsandkeeygpvvvhcsagvGrtGtiialdial

ERLKTEQVIDVFQVIKRIRVNLPGAVESPTQYMFCYQIIQK
|.||.|. .|.  ..| .| .    |..  ||.| |. . .
eqlklenkvdikgivkvlrkqrkqmvqalcqyvfiynavle
0049772 (Phosphotyrosine protein) phosphatases II 260-503 3.3e-43 143.9 In-house 37-281 (314) alignment 
Range on Protein: 260-503
Range on HMM: 37-281/314.0
PWEAARKPANKNKNRYANIVAYDhSRVVLERVNGDeDSDYINASFIHGYdgtpRSFIASQGPLPPAFEDF----------WRMV--WEQNSQSIVM----
 . .|....|..|||| .|. .| .||.| ..... .|||||||...|.    ..|||.||||.  ..||          ||||  ...|.  |||    
tilvadlflnrdknryldilpad.nrvilpglpvs.gsdyinasyvdgf....lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivmsrde

-----------------LTNLVELGKTKCHKYWPDKTetyggvtvtlhqseifaeyeirtfilSKA--KQSGSRMVRQFHFTVWPDKGVPqYATAVLAFR
                 |..| ..|   . .....                            .    ..  .|.. ... . .|| ..|     ...| 
vladelsrLdaAlgKtpllildgngneptaadlellk..........................eelydpelferlgikylripvpDgsap.lledfdefl

RKVRALnpRDAGPVIVHCSAGVGRTGAYIVIDAMLEQAKksrtVDIRNYLIALRKDRP-----HMVQTKEQYSFIHSAVLEALT
. ....  .. |||.|||.||.|||| ..|.. .. . .    |...  |  .|. ||     ..... ||| ||. |.||.| 
efieea..dkggpvlvHCkaGkgRtgtfvvaaylmkllg....vsleealedvrlkRpinpnpgfieqleqyefilealleylk
0046846 (Phosphotyrosine protein) phosphatases II 291-500 4.2e-43 142.4 In-house 6-171 (176) alignment 
Range on Protein: 291-500
Range on HMM: 6-171/176.0
VNGDEDSDYINASFIHGYDgtprsFIASQGPLPPAFEDFWRMVWEQNSQSIVMLTNLVELGKTKCHKYWPDKTETYGgvtvtlhqseifaeyeirtfils
   |.|.|||||..| |.      .|| |||||  ..||..|..|.. . .|.||..||||. ||. |||. ..                          
lgldldldyinanlilgsr.....piatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgi.......................

kakqsgsrmvrQFHFTVWPDKGVPQYaTAVLAFRRKVRALNPRDaGPVIVHCSAGVGRTGAYIVIDAMLEqakkSRTVDIRNYLIALRKDRP-HMVQTKE
           |.... ||| |||.. ...| . . .|    .. |||.||||||.||||...... .      .. ... . |  .|. || ..||| |
...........qylhlpwpDhgvpdl.elllellefirealkeg.gpvlVHCsaGigRtgtlvaayllel....ekglsveealalvreqRplgavqtpe

QYSFIHSAVLE
|| |.. ..|.
Qyrflyefell
subfamily_PTPRN_pd Subfamily PTPRN 549-792 1.9e-42 140.0 In-house 44-289 (297) alignment 
Range on Protein: 549-792
Range on HMM: 44-289/297.0
PAEEKSVGEEPQNLHKNRFSDIIALNSCRVMLHKEHADEESDYINAVFLHAHRGRN-AFIATQHPLLETVEDFWRMVTDYDIGTIVMLNNLHELDQEY-P
  . |.|.....|..||| ..... .  || |..| ..|.|||||| ..  |  |. |.|||| || .|| |||.|| .  .  ||.| .|.| . .   
epstkevakaeknvkknrskavlpydhsrvklkeeasaeksdyinasaildhdprapayiatqgplastvadfwqmvweqGvvvivnltrleeegvkqck

KYWPDHGPTKYGHIGVSVLSKQEQGDVICTKLKVTRKKVRRKTHEVRHLHHVSWPDKCIPEVACSVLDLLDEAQTSQQQcGNAPVLVQCSNGVGRSGTFC
.||||.|   |.   | ..|.    |    .    .    ..|  |  .|..|||.. .|  | |.|..    . | .    .|..| ||.|.||.|...
rywpdeGsevyhiyevhlvsehiwcddylvrsfylknlqtsetrtvtqfhflswpeegvPasaksllefrrkvnksyrG.rscpivvhcsdGaGrtGvyi

AISSVLERL-KTEQVIDVFQVIKRIRVNLPGAVESPTQYMFCYQIIQ
.|  ||.|| |  . ||.   .. .| . || |..  |. |... . 
lidlvlnrllkGvkeidiaatlehlrdqrpglvktkdqfefaltava
0043147 (Phosphotyrosine protein) phosphatases II 293-495 6.1e-42 138.6 In-house 1-154 (172) alignment 
Range on Protein: 293-495
Range on HMM: 1-154/172.0
GDEDSDYINASFIHGYDGTPRsFIASQGPLPPAFEDFWRMVWEQNSQSIVMLTNLvelgktkchkywpdktetyggvtvtlhqseifaeyeirtfilSKA
|||.|||||||....|  ..| ||| ||||.  ..|||||..|.. . ||.||.|                                           . 
gdegsdyinasyldlyyipdr.fiatqgplrntladfwrmlkelgithivnltel..........................................lyd

KQSGSRMVRQFHFTVWPDKGVPqYATAVLAFRRKVRA-LNPRDAGPVIVHCSAGVGRTGAYIVIDAMLeqakksRTVDIRNYLIALRKDRPHMVQTKEQY
..  .|.. |.... ||| |||  .  .| | . ..  |. .. |||.|||||||||||. .... ||      . ... . .  .|. ||..||...||
pellerlgiqylylpwpDhgvp.llellleflefidellalspggpvlVHCsaGvgRtgtlvaaylml......lglsleeavalvrekRpgavqnpsqy

SFIH
 |..
rfly
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 536-794 1.3e-41 137.4 In-house 11-258 (267) alignment 
Range on Protein: 536-794
Range on HMM: 11-258/267.0
EFQRLNSVTSREIPaEEKSVGEEpqNLHKNRFSDIIALNSCRVMLHKEHADeesdYINAVFLHAHRGRNAFIATQHPLLETVEDFWRMVTDYDIGTIVML
||. .. ... .     .|..|.  |  .||. | .  .  ||.| ..  .    |||| ...... .||||.|| ||  |. ||. ...|... .||.|
efelikkisdtsst.isqsiaek..nqernrlddnlpyddtrvilrtkeee....yinasyvegyktknafivtqdplkntitdfltvihdqkvpvivll

NNLHEldQEYPKYWPDH--GPTKYGHIGVSVLSKQEQGDVICTKLKVTRKkvRRKTHEVRHLHHVSWPDKCipEVACSVLDLLDEAQTSQQQCGNAPVLV
 .  .  .. ...|| .     ||  . |    ..|. |     |..  |     .|.|   ..  |  .   .    .  |.      | . || |..|
tkvft..dnirlfwPPkmgqakkyqdltvehslekeendyqiitlelkfk..nesahnvtlyyykkwnint..nnkpylkplfgilaknqlengnrPlvv

QCSNGVGRSGTFCAISSVLERLKTEQVIDVFQVIKRIRVNLPGAVESPTQYMFCYQIIQKY
.||.||||||||  | | |||.|||.| |.|. ...||   .| |..  .|....... .|
acsdGvGrsGtflvidsqleraktegvsdifdflrkirsqriglvdtkeryiyihellaey
subfamily_PTPN1_pd Subfamily PTPN1 552-791 1.4e-41 137.1 In-house 23-267 (290) alignment 
Range on Protein: 552-791
Range on HMM: 23-267/290.0
EKSVGEEPQNLHKNRFSDIIALNSCRVMLHKEHAdeesDYINAVFLHAHRGRNAFIATQHPLLETVEDFWRMVTDYDIGTIVMLNNLHELDQE-YPKYWP
. .. ..|.|  .||. |.   . .|..|....     ||||| ...... .  .| || || .||. ||.|| . .  ..||||.. | .|    .|||
ptreaklpenrnlnryrdvspydhsrikleradn....dyinaslveleeakrsyiltqGPlpntvdhfWqmvWeqkskavvmlnkvvekeqikcaqywP

DHGP---TKYG--HIGVSVLSKQEQGDVICTKLKVTRKKVrRKTHEVRHLHHVSWPDKCIPEVACSVLDLLDEAQTSQQQC-GNAPVLVQCSNGVGRSGT
 .      ..   .. | ..|....   .  .|... .|  ..|.|. | |...|||  .||   . |..| . . |        |... || |.|||||
qgeeekellledtklkvkliseerksyytvrllelenlkt.qetreilhfhyttwpdfgvpespaaflkflfkvresGslssdvGpavihcsaGiGrsGt

FCAISSVLERLKTEQ---VIDVFQVIKRIRVNLPGAVESPTQYMFCYQII
|| . ..| ... ..    .|. .|.  .|    | .  . |  | |. |
fclvdtclvliekkddlssvdikkvllelrkyrlGliqtadqlrfsylai
subfamily_PTPN14_pd Subfamily PTPN14 541-796 7.2e-41 135.1 In-house 30-297 (300) alignment 
Range on Protein: 541-796
Range on HMM: 30-297/300.0
NSVTSREIpAEEKSVGEEPQNLHKNRFSDIIALNSCRVMLHKEHADeESDYINAVFLHAHRG--RNAFIATQHPLLETVEDFWRMVTDYDIGTIVMLNNL
. .. ..    . |... |.| .|||| |..  . .|| |   . . ...||||  ...  |  .  .|..| ||  ||.|||.|| . ..  |||| . 
eripkkre.dallstaklpenaeknrfkdvlPyednrvelsptken.stgyinassikvsvggkersyivaqgPleltvqdfWqmvWeqgvqlivmltee

HELDQE-YPKYWPDH----GPTKYGHIGVSVLSKQEQGDVICTKLKVTRKKvRRKTHEVRHLHHVSWPDKCIPEVACSVLDLLDEAQTSQQ--------Q
.|  .|   ||.|..       ..|.  |.   ... . || |.||.      ..  .| || .. |||. .||   . |. |.| |  ..        .
eedgkeksfkyfPkleskkktvefgkfkvttkfsedsdsvittglklkhlp.skeertvwhlqytDWpdhgvPeDvkgflsyLeevqsvrrktnsevesk

CGNAPVLVQCSNGVGRSGTFCAISSVLERLKTEQVIDVFQVIKRIRVNLPGAVESPTQYMFCYQIIQKYLD
  . |||| ||.||||.|       ... |.....||. .|..|.|      |.. .|| | |... |||.
eskPPvlvhCsaGvGrtGvlilsdlliatlehneeidikkvlarLreqrmllvqtlaqYkfvYkvlikylk
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 549-791 8.8e-41 134.6 In-house 33-232 (392) alignment 
Range on Protein: 549-791
Range on HMM: 33-232/392.0
PAEEKSVGEEPQNLHKNRFSDIIALNSCRVMLHKEHADEESDYINAVFLHAHRGRNAFIATQHPLLETVEDFWRMVTDYDIGTIVMLNNLHELDqeypky
.. ...|.... ||.|||. .|. ..| ||.|       .|||.|| ....    .|.||.| |   ...|||||| . .. ||.|...|.| |      
diypqtvaqkeinlkknryknilpydsarvkleviddipdsdylnasyipsfdnekayiasqgpnaaslddfwrmvfqenvttiamvtklkegd......

wpdhgptkyghigvsvlskqeqgdvictklkvtrkkVRRKTHEVRHLHHVSWPDKCIPEVACSVLDLLDEAQTSQQQCGnAPVLVQCSNGVGRSGTFCAI
                                       ... |   | . |||| .|. ..|.| .. | ..   |    |....|| ||||.|   .|
....................................kgddartvaqfhftewPdkdvpkhtssllkfikevkadfGqyt.hpliihcsagvgrtgvvisi

SSVLERLKTEQVIDVFQVIKRIRVNLPGAVESPTQYMFCYQII
 ||. . |. ...|||...  || . |  |..  || | |  .
dsvvahakktrmvdvfnfvtnirrkrpymvqtkeqyafiygav
0036282 (Phosphotyrosine protein) phosphatases II 589-789 1.7e-40 133.9 In-house 2-164 (174) alignment 
Range on Protein: 589-789
Range on HMM: 2-164/174.0
SDYINAVFLHAHRGRNAFIATQHPLLetvedFWRMVTDYDIGTIVMLNNLHELD-QEYPKYWPDhgptkyghigvsvlskqeqgdvictklkvtrkKVRR
|||||| .|. ..  . .||.|.||      ||.|. ...| |.|||....||.    . |||.                                .   
sdyinaspldlsyitprliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe................................lred

KTHEVRHLHHVSWPDKCIPEVACsVLDLLDEAQTSQQQCGNAPVLVQCSNGVGRSGTFCAISSVLERLKtEQVIDVFQVIKRIRVNLPGAVESPTQYMFC
 .... ..... ||| . |...  .|........ ...... |||| || ||||.||..|.  .| .|. | ..|........|   ||.|..| ||.|.
lerlgiqylylpwpDhgvpdlsi.llefvkfveealsedpggpvlVHCsaGvgRtGtlvaaylmlrgll.eslvdaldlvrelRlqrpgmvqtpsQyrfl

YQ
|.
yy
0049260 (Phosphotyrosine protein) phosphatases II 312-495 3.5e-40 132.5 In-house 8-143 (152) alignment 
Range on Protein: 312-495
Range on HMM: 8-143/152.0
PRSFIASQGPLPPAFEDFWRMVWEQNSQSIVMLTNLVELGKTKCHKYWpdktetyggvtvtlhqseifaeyeirtfilskakqsgsrmvrQFHFTVWPDK
|. ||| |||.|  ..|||||..|.. . |||||.|.|||| ||..|.                                          |.... ||| 
pfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi..........................................qylhlpwpDh

GVPQYATAVLAFRRKVRALNPRDAGPVIVHCSAGVGRTGAYIVIDAMLeqakksRTVDIRNYLIALRKDRPHMVQTKEQYSFIH
|||. .  .| . . .. |. .. |||.|||||||||||...... ||      . |.. ...  .|. ||..|....|. |..
gvpdlsqlllflllfieklaldkggpvlVHCsaGvgRtgtlvaaylml......lgvsleeavalvrekRpgavpnpgqlrfly
0041856 (Phosphotyrosine protein) phosphatases II 561-793 3.9e-40 132.7 In-house 1-169 (182) alignment 
Range on Protein: 561-793
Range on HMM: 1-169/182.0
NLHKNRFSDIIALNSCRvmlhkehadeESDYINAVFLHAHRGRNAFIATQHPLLETVEDFWRMVTDYDIGTIVMLNnlheldqeYPKYWPDHGptkyghi
||.|||.|||.  .  |           .||||| ..   .  . |||||.|||.||.||.||. ...|.|||.|.         . |||..        
nldknrysdilpydhsr..........dldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt........eelywpell.......

gvsvlskqeqgdvictklkvtrkkvrrkTHEVRHLHHVSWPDKCIPEvACSVLDLLDEAQTsqqqcGNAPVLVQCSNGVGRSGTFCAISSVLERlkteQv
                            .... ......||| ..|.   ..||...|..       . |||| || ||||.||..|.  ....    . 
............................erlgiqylylpwpDhgvpd.ldelldfieevle.....eggpvlVHCsaGvgRtgtlvaaylmkkl....g.

IDVFQVIKRIRVNLPGAVESPTQYMFCYQIIQK
.......| .|   ||.|..| || |.....  
vsleeavklvrsrRpgmvitpnqyfflqlalle
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 269-500 5.5e-40 132.1 In-house 33-257 (267) alignment 
Range on Protein: 269-500
Range on HMM: 33-257/267.0
NKNKNRYANIVAYDHSRVVLERVNGDedsdYINASFIHGYDgTPRSFIASQGPLPPAFEDFWRMVWEQNSQSIVMLTNlveLGKTKCHKYWPDK---TET
|...||. . . ||..||.|   . .    |||||...||  | . ||. |.||  .  ||. .. .|.   ||.||.    .. . ...|| |   .. 
nqernrlddnlpyddtrvilrtkeee....yinasyvegyk.tknafivtqdplkntitdfltvihdqkvpvivlltk...vftdnirlfwPPkmgqakk

YGGVTVTLHQSEIFAEYEIRTFILsKAKQSGSRMVRQFHFTVWPDKG-VPQYATAVLAFRRKVRALNprDAGPVIVHCSAGVGRTGAYIVIDAMLEQAKK
|  .||     .   .|.| |. | | |.  .. |  ...  |  .     |   ...   | .  |     |..|.||.||||.|...|||..||.||.
yqdltvehslekeendyqiitlel.kfknesahnvtlyyykkwnintnnkpylkplfgilaknqlen..gnrPlvvacsdGvGrsGtflvidsqlerakt

SRTVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVLE
  ..|| ..|  .|. |. .|.|||.| .||  . |
egvsdifdflrkirsqriglvdtkeryiyihellae
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 250-500 7.6e-40 131.4 In-house 36-287 (305) alignment 
Range on Protein: 250-500
Range on HMM: 36-287/305.0
YKKFDNGQQFpWEAAR-KPANKNKNRYANIVAYDHSRVVLERVNgdeDSDYINASFIHGYDGTPRSFIASQGPLPPAFEDFWRMVWEQNSQSIVMLTNLV
| . |  |.  ..| .    .. ||||... . |.| | |.. .    |||| | ..       . ||..||||  . ..|| || ... . |||| . |
ytrpdmtqva.fnanqsadiaitknryqdvpcqdqsavkldkps...psdyihanyvgcpmipekrficaqgpldqtidefwwmviqnkveqivmlcktv

ELGKTKCHKYWP----DKTETYGGVTVTLHQ-S-EIFAEYEIRTFILSKAKQSGSRM-VRQFHFTVWPDKGVPQYATAVLAFRRKVRAlnprDAGPVIVH
|||| || .|||    .| |  .|. |     |  .  . ||.  .|  .   . .| ||....| |||.|||    . | .   .|        |..||
elgklkcaqywpaaqgeklelksgivvenvsgskpmerdaeiqitllnltysgdqkmsvrhlqwtewpdrgvppckltslellsairg....skvpivvh

CSAGVGRTGAYIVIDAMLEQAKKSR-TVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVLE
||||.||||. . |. .||.  . .    . . . ||| .| . .|.  || |||  .|.
csagigrtgtivaieyilekiaenkpcppmpelvkalrdqrafsiqndvqylfihrvmln
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 247-501 7.8e-40 131.5 In-house 25-286 (305) alignment 
Range on Protein: 247-501
Range on HMM: 25-286/305.0
ETEYKKFDNGQQFPW-EAARKPANKNKNRYANIVAYDHSRVVLervNGDEDSDYINASFIHGyDGTPRSFIASQGPLPPAFEDFWRMVWEQNSQSIVMLT
 .|.. .   ..|   .| ..  ...|||| ..   |. || |   .|    .|| | ..      |. || .| ||  .  ||| | .... ..| || 
raefvamkrfndfekmkafkeaqeagknrykdvgcldnnrvkl...egpwpheyihanyvst.ptnpkrfictqaplektcadfwymclqdkveaifmlc

NLVELGKTKCHKYWPDKTE-------TYGGVTVTLHQSEIF-----AEYEI-RTFILSKAKQSGSRMVRQFHFTVWPDKGVPQYATAVLAFRRKVRALNp
||.| |  ||..|.. | .           ..| .  |. .     |. .. .| .. .   . .| | ..|.  |||.|||   .|.| .  | |..  
nllekgakkcleyfaskdkdvlefeekgqkisvkfessvtlkfrkdakakvtetvlviegpgekarkvthyhwidwpdrgvpaadlailellekarpsk.

rdaGPVIVHCSAGVGRTGAYIVIDAMLEQAKKSRTVDIRN-YLIALRKDRPHMVQTKEQYSFIHSAVLEA
   ||..||||||.||||. .... .|.|    . ..  .  |  .|..|   .|| .|| |.|  .|. 
...gpivvhcsagigrtgsvvmleyildqllagqiiedtdkilqkireqrnnsiqtdaqylfvhqvilny
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 560-791 9.8e-40 131.2 In-house 2-235 (237) alignment 
Range on Protein: 560-791
Range on HMM: 2-235/237.0
QNLHKNRFSDIIALNSCRVMLHKEHADeeSDYINAVFLHAHRGR-NAFIATQHPLLETVEDFWRMVTDYDIGTIVMLNNLHELDQE-YPKYWPDH-GPTK
.|  |||...|.| . .||.|.   ..  |||||| .|.   |  . .||.| ||  . .|||.|| .     ||||  | | ...   ||||.   |. 
enkiknrygnivaydhsrvvlkgagsg..sdyinatylkgfdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywpstdqpaa

YGHIGVSVLSKQEQGDVICTKLKVTRKKVRRKTHEVRHLHHVSWPDKCIPEVACSVLDLLDEAQ-TSQQQCGNAPVLVQCSNGVGRSGTFCAISSVLERL
|| . ||.  |.|  |     | ....   ..   .   .  ||||. .|. ....| .  .    |.     .| .. || ||||.| |  | ..| . 
ygvltvslkkkeefsdytvrslllskrltlkevrlihqyqftswpdrgvpqqtaallrfrkniinrsphvsesgpwiihcsagvgrtgiflvidamlrqa

KTEQVIDVFQVIKRIRVNLPGAVESPTQYMFCYQII
| ..|.|... .. |  . |  ...  ||.| .| |
kekkvvdiynyvysieedrpyiiqtkdqyvfihqti
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 516-796 1.9e-39 130.1 In-house 12-284 (290) alignment 
Range on Protein: 516-796
Range on HMM: 12-284/290.0
QAMQKLASVNRKFQMTGYALEFqrLNSVTSR-EIPAEEKSVGEEPQNLHKNRFSDIIALNSCRVMLHKehaDEESDYINAVFLHAHrgRNAFIATQHPLL
.|..|.||   | .. ..| |.  |. .         |... ..  ...|||. |..  .  ||.|.      . ||. | ...    .  || || .| 
eafekfasdvvkknvdelakey..leklkpylpvqylerkifdkntefkknrykdvvcndktrvilkd...GydGdyvhanyvkGl..kamfiltqGalk

ETVEDFWRMVTDYDIGTIVMLNNLHELDQ-EYPKYWPDHGP--TKYGHIGVSVLSKQEQGDVICTKLKVTRKKVRRKTHEVRHLHHVSWPDKCIPEVACS
.|| |.|||| . .. .|||| .| |  .    .|.|..      .|.| |    .... . |  |.   |.|   | | ..||. .|||||...  . .
dtvidiwrmvlqekvaaivmlceliedGkakceqyypekeGevltfGeitvlcseeddkdaniikktlsvrdkdsGkehklkhlkikswpdksvalstla

VLDLLDEAQTSqqqcgNAPVLVQCSNGVGRSGTFCAISSVLERLKTEQVIDVFQVIKRIRVNLPGAVESPTQYMFCYQIIQKYLD
.| .|   ..      . || | || |.||.||| ||   |. |   . .|. .... .|    ..|.  .||.   .|. ..  
llrtlrilrka.....sGpvvvhcsaGiGrtGtfvaievglqilldGkeldlldlvralrnsrlnsvqvdiqylalveilldlGk
0049772 (Phosphotyrosine protein) phosphatases II 521-802 6.2e-39 129.9 In-house 6-287 (314) alignment 
Range on Protein: 521-802
Range on HMM: 6-287/314.0
LASVNRKFQMTGYALEFQRLNSVTSREIPAEEKSVGEEPQNLHKNRFSDIIALNsCRVMLHKEHADEeSDYINAVFLHAHrgrNAFIATQHPLLETVEDF
|||...  ..  .  ....||... . .|.    |.  . | .|||. ||.  . .||.|.... .  |||||| ... .   ..|||||.|| .||.||
lasfsellihddllklllvlnrrslsvlpeltilvadlflnrdknryldilpad.nrvilpglpvsg.sdyinasyvdgf...lkfIatqgpleitvvdf

----------WRMV--TDYDIGTIVM---------------------LNNLHEL-DQEYPKYWPDHGptkyghigvsvlskqeqgdvictklK-------
          ||||   |... .|||                     |..| .. ..  .......                          .       
reepvlyyngwrmvlrgdlnvrdivmsrdevladelsrLdaAlgKtpllildgngneptaadlellk.........................eelydpel

VtrkkvrrkTHEVRHLHHVSWPDKCIPeVACSVLDLLDEAQTSqqqCGNAPVLVQCSNGVGRSGTFCAISSVLERLKteqViDVFQVIKRIRVNLP----
.        .... ..... .|| . |     ....|.  ..      . |||| |. |.||.|||...  .. .|.   | .. ......|   |    
f........erlgikylripvpDgsap.lledfdeflefieea...dkggpvlvHCkaGkgRtgtfvvaaylmkllg...v.sleealedvrlkRpinpn

-GAVESPTQYMFCYQIIQKYLDSFSDYA
 |..|.. || |.......||. . .. 
pgfieqleqyefilealleylkflkkfy
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 546-796 8.5e-39 128.0 In-house 24-278 (287) alignment 
Range on Protein: 546-796
Range on HMM: 24-278/287.0
REIPAEEKSvGEEPQNLHKNRFSDIIALNSCRVMLHKEhADEESDYINAVFLHAHRGRNAFIATQHPLLETVEDFWRMVTDYDIGTIVML-NNLHELDQE
.  .|  |.  ||  . .|||..|.. ..  ||.| .| ..  |||||| .. ...  .||||.| |.  || ||||.| .    .....  .. |  ..
esstatfka.aeelaavkknryadvlPiddtrvllsae.gelGsdyinanyvasytddeafiaaqgPiaatvrdfwravletrsasvitmtreveearlk

YPKYWPD-HGPTKYGHIGVSVLSKQEQGDVICTK-LKVTRKKvRRKTHEVRHLHHVSWPDKCIPEV----ACSVLDLLDEAQTSQQQCGNAPVLVQCSNG
  ||||. . | . |   | .|... .    ... |..   .  |... |. |. .||||| ..      .  |||  .  . ...  .  |..| .. |
cykywPerevPmrvGGysvvlldydikePeygvralrlidle.trearvvkqldllswPdkvlaPtavglirfvldvkqhielardasevGPlvvhddvG

VGRSGTFCAISSVLERLKTEQVIDVFQVIKRIRVNLPGAVESPTQYMFCYQIIQKYLD
.||||.. |.  ...||.    .|| .|. |.|    . | .. |. . |. .  |  
iGrsGillatlvlvsrledlGrvdvaavvirlreyraalvqavvqlrllyealvtyyk
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 561-788 2e-38 126.9 In-house 8-234 (239) alignment 
Range on Protein: 561-788
Range on HMM: 8-234/239.0
NLHKNRFSDIIALNSCRVMLHKEHADEESDYINAVFLHAHRGR-NAFIATQHPLLETVEDFWRMVTDYDIGTIVMLNNLHELDQ-EYPKYWPDHGpTKYG
|  |||...|.. .  ||.| |   |  |||||| .|. . |  .|.||||  .  .  |||||. .     ||||  | |  . .  .||||   .|| 
nkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdst.skyc

HIGVSVLSKQEQGDVICTKLkVTRKKVRRKTHEVRHLHHVSWPDKCIPEVACSVLDLLDeAQTSQQQCGNAPVLVQCSNGVGRSGTFCAISSVLERLKTE
 . |..   .   | |   . |  .  . . . | . |   |||| .|. | .|| |     | .   |  | ...|| ||||.|.|  | ..| . | .
nlrvtlrktevfadyiirtf.vmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrr.kitkdslpgarpwvihcsagvgrtgaflvidamlrqakkq

QVIDVFQVIKRIRVNLPGAVESPTQYMFCY
. .|.|. .| || . |  |..  ||.| .
ktvdifnyvkairedrphmvqtseqyvfih
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 561-788 2.1e-38 126.9 In-house 7-233 (239) alignment 
Range on Protein: 561-788
Range on HMM: 7-233/239.0
NLHKNRFSDIIALNSCRVMLHKEHADEESDYINAVFLHAHRGR-NAFIATQHPLLETVEDFWRMVTDYDIGTIVMLNNLHELDQ-EYPKYWPDHGpTKYG
|  |||...|.. .  ||.| |   |  |||||| .|. . |  .|.||||  .  .  |||||. .     ||||  | |  . .  .||||   .|| 
nkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdst.skyc

HIGVSVLSKQEQGDVICTKLkVTRKKVRRKTHEVRHLHHVSWPDKCIPEVACSVLDLLDeAQTSQQQCGNAPVLVQCSNGVGRSGTFCAISSVLERLKTE
 . |..   .   | |   . |  .  . . . | . |   |||| .|. | .|| |     | .   |  | ...|| ||||.|.|  | ..| . | .
nlrvtlrktevfadyiirtf.vmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrr.kitkdslpgarpwvihcsagvgrtgaflvidamlrqakkq

QVIDVFQVIKRIRVNLPGAVESPTQYMFCY
. .|.|. .| || . |  |..  ||.| .
ktvdifnyvkairedrphmvqtseqyvfih
0044763 (Phosphotyrosine protein) phosphatases II 281-499 2.2e-38 127.0 In-house 2-168 (178) alignment 
Range on Protein: 281-499
Range on HMM: 2-168/178.0
YDHSRVVLERVNGDEDSDYINASFIHGYdgtprSFIASQGPlppafEDFWRMVWEQNSQSIVMLTNLVELGKTKCHKYWPDKTEtyggvtvtlhqseifa
.|..||.|. . | | |||||||.| ..      ...|..|     .|......|.. ..||.||. .|||. ||..|||....                
ldrtrvllsnleglersdyinaseilpg.....lylgslpp.....addlellkelgithivnlteelelgflkcdpywpeeag................

eyeirtfilskakqsgsrmvRQFHFTVWPDKGVPQYATAVLAFRRKVRALNPRDAGPVIVHCSAGVGRTGAYIVIDAMLEQakksrTVDIRNYLIALRKD
                     |.... .|| |||.    .|.| . .... ... |||.|||||||||.|. .... |...      ... . .  .|. 
....................iqylhipipDhgvpdllehflefvefieealdekggpvlVHCsaGvgRsgtlvaaylmkkl.....glsleeaielvrer

RPhMVQTKEQYSFIHSAVL
|| .|.. .|. ...   |
Rp.ivpnpgqlrqLyefel
subfamily_CG42327_pd Subfamily CG42327 267-428 3e-38 126.3 In-house 26-191 (319) alignment 
Range on Protein: 267-428
Range on HMM: 26-191/319.0
PANKNKNRYANIVAYDHSRVVLERVNGDEDSDYINASFIHGYDGTPRSFIASQGPLPPAFEDFWRMVWEQNSQSIVMLTNLVELGKTKCHKYWPD-----
.. |.|.|..|.|   ..||||.|.  |. . |..||.. ||| .| |.||.| .|  .  ||||.||||.|. || ||.| |||  .| .|.|      
vtskdksrvinvvPlPetrvvlqrigdddkdeyldasyvrGyddapnsyiaaqvsledsssdfwrtvweqqsrvivqltdlselGikvcaeylPtketld

KTETYGGVTVTLHQSEIFAEYEIRTFILSKAKQSGSRMVRQFHFtVWPDKGVPQYATAVLAFRRKVR
 |..|| . ||| . |.  .| | |..| . ... || .  . .  |.. .||   .|..|   .||
ntslyGdilvtlkgrevkdryaistlllkrvdkeesrelthywy.kwleaevPaeeaaliamllevr
subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 246-510 1.6e-37 123.7 In-house 29-297 (310) alignment 
Range on Protein: 246-510
Range on HMM: 29-297/310.0
LETEYKKFDNGQQF--PWEAARKpaNKNKNRYANIVAYDHSRVVLErVNGDEDSDYINASFIHGyDGTPRSFIASQGPLPPAFEDFWRMVWEQNSQSIVM
|  .|.|.|  |.    .|| .|  .  ||||...|  | ||| |. ..     ||| | ...  .    .|| |||||  .  |||||.... ..||..
lvkqyrkldakqdssltyeaykk..ymhknrysdvvcldtsrvklk.idksryedyihanyvkt.nylrstficsqgplqhtiidfwrmifqeraesill

LTNLVELGKTKCHKYWPD--KTETYGGVTVTlHQSEIFAEYEIR----TFILSKA---KQS---GSRMVRQFHFTVWPDKGVPQYATAVLAFrrkvRALN
| . .| |. ||  |||    ||||| . ||   ||   |.||     ||.  .    .|        |   ..  |||.|||.     .      | | 
lckvgeegrpkcvgywpslgvtetygcirvt.nlsesseefeicnlavtfvpdnvpvdeqpanlkelrvslikwpnwpdrgvpdekchtvpq....rlla

PRDAGPVIVHCSAGVGRTGAYIVIDAMLEQAKKSRTVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVLeALTCGNTEIQ
    ||..||||||..|... . ..  ......   ||. .    |.|.|   .||. || .|.   . ... |.||. 
qvrhgpcvvhcsagkdrlyvvvalklkidkldrglkvdaeevktellksraiciqtelqyliidrvri.ifargeteva
subfamily_ptpA1_pd Subfamily ptpA1 266-460 6e-37 122.3 In-house 44-254 (418) alignment 
Range on Protein: 266-460
Range on HMM: 44-254/418.0
KPANKNKNRYANIVAYDHSRVVLERVNGDEDSDYINASFIHGydGTPRSFIASQGPLPPAFEDFWRMVWEQNSQSIVMLTNLVELGKTKCHKYWPDKT--
|  | .||||.||.  .|.|| |....  | |||||| .| |    |. ||..||||| .  ||||||||.  . ||||.   |  . || .|||..   
kkhntsknrytnilpvnhtrvqlkkiqdkegsdyinanyidg..aypkqfictqgplpntiadfwrmvwenrcriivmlsresencrikcdrywpeqigg

----------ETYGGVTVTLHQSEIFAEYEIRTFILSKAKQSGSRMVRQFHFTVWPDKGVPQYATAVLAF-----RRKVRALNPRD-AGPVIVHCSAGVG
          | .|  .| | .     | || |  .  . .  .| . |...  |||. .|...  .  .      |. . .   |   |.|||||||||
eqfsiygngnevfgtysvelveviqdpereiitrnirltfegetrditqyqyegwpdhnipdhtqpfrqllhsitnrqnqiipssdrnvpiivhcsagvg

RTGAYIVIDAMLE
|||..     |..
rtgtfctavimmk
0043147 (Phosphotyrosine protein) phosphatases II 586-789 7.5e-37 122.1 In-house 2-155 (172) alignment 
Range on Protein: 586-789
Range on HMM: 2-155/172.0
DEESDYINAVFLHAHRGRNAFIATQHPLLETVEDFWRMVTDYDIGTIVMLNNLheldqeypkywpdhgptkyghigvsvlskqeqgdvictklkvtRKKV
|| |||||| .|. ..  . ||||| || .|..|||||. ...|..||.|..|                                            .  
degsdyinasyldlyyipdrfiatqgplrntladfwrmlkelgithivnltel...........................................lydp

RRKTHEVRHLHHVSWPDKCIPeVACSVLDLLDEAQTSQQQCGNAPVLVQCSNGVGRSGTFCAISSVLerlkteQVIDVFQVIKRIRVNLPGAVESPTQYM
   .... ......||| . |  .  .|..|.  .. .... . |||| || ||||.||..|.  .|      . ........ .|   ||||..| ||.
ellerlgiqylylpwpDhgvp.llellleflefidellalspggpvlVHCsaGvgRtgtlvaaylml......lglsleeavalvrekRpgavqnpsqyr

FCYQ
|.|.
flyy
0046846 (Phosphotyrosine protein) phosphatases II 582-796 8.4e-37 122.0 In-house 5-174 (176) alignment 
Range on Protein: 582-796
Range on HMM: 5-174/176.0
KEHADEESDYINAVFLHAHRgrnaFIATQHPLLETVEDFWRMVTDYDIGTIVMLNNLHELDQEY-PKYWPDhgPTKYGHigvsvlskqeqgdvictklkv
. . |. .||||| ..  .|    .||||.|| .|..||..|. ...|...|.|....||..   | |||.   .|.|.                     
llgldldldyinanlilgsr....piatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpe..leklgi.....................

trkkvrrkthevrHLHHVSWPDKCIPEVaCSVLDLLDEAQTSQQQcgNAPVLVQCSNGVGRSGTFCAISsvleRLKTEQVIDVFQVIKRIRVNLP-GAVE
             . .|. ||| ..|.    .|.||.. .. ...  . |||| || |.||.||..|.      |..|. ..|.......|   | |||.
.............qylhlpwpDhgvpdl.elllellefirealke..ggpvlVHCsaGigRtgtlvaay....llelekglsveealalvreqRplgavq

SPTQYMFCYQIIQKYLD
.| || |.|. ....|.
tpeQyrflyefellllk
subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 265-500 2.3e-36 119.9 In-house 33-267 (281) alignment 
Range on Protein: 265-500
Range on HMM: 33-267/281.0
RKPANKNKNRYANIVAYDHSRVVLER-VNGDEDSDYINASFIHGyDGTPRSFIASQGPLPPAFEDFWRMVWEQNSQSIVMLTNLVELGKTKCHKYWPDKT
 .| |..||||.|| . | ||| |.  .   . .||| | .|.      | .| .|||   .  |||||.|..|. .|||| ...|  . || .|.| ..
nqpvnnkknrylnipcldisrvqlkvkmpnknstdyihanyirs.pflkrgyiltqgpkketradfwrmiwqenttaivmlcqfletnrekcaeyfprna

ET---YGGVTVTLHQSEIfaEYEIRTFILSKAKQSGSRMVRQFHFTVWPDKGVPQYATAVLAFRRKVRAlnpRDAgPVIVHCSAGVGRTGAYIVIDAMLE
     .  ..|.  .| .  .  . |  |  . .  .|.. .. .  |||  ||. .  .|   ||.||   | . | ..||||||||.|. . ..  |.
hcclqfdklsvsyedstv..nkslvttrlnlsyegetrlithwlwkewpdwqvpessevmlkilrkira...rst.ppvihcsagvgrsgtlmaveialq

QAKKSRTV-DIRNYLIALRK-DRPHMVQTKEQYSFIHSAVLE
  .   |. ||.. .  ||   |   ||| .|| .|   .|.
sihshftlpdikqivshlrvtgraasvqtlqqymliwkvlld
0051082 (Phosphotyrosine protein) phosphatases II 296-499 5.4e-36 118.8 In-house 2-150 (151) alignment 
Range on Protein: 296-499
Range on HMM: 2-150/151.0
DSDYINASFIHGYdgtprsFIASQGPLPpafeDFWRMVWEQNSQSIVMLTNLVELGktKCHKYWPDKTetyggvtvtlhqseifaeyeirtfilskakqs
 |||||.|.. |.      ...|.|||.    ||.....|.. ..||.|....| |  .|..|.|.                                  
lsdyinfsyvtgg......lyrsggpla....dflellkelgiktivnlrseeerg..ycpeylpelg................................

gsRMVRQFHFTVWPDKGVPQYATAVLAFRRKVRAlnpRDAGPVIVHCSAGVGRTGAYIVIDAMLEQakksrtVDIRNYLIALRKDRPHMVQTKEQYSFIH
  . |...... ||| |.|..  |||.| .....    . |||.||||||.||||. .... ||..      |..   |  .|. ||..||...|. |..
..ievlhipildwpdpglplsfdavleflellld...kkngpvlvHCsaGkgRTGtlvalylmllg......vsleealeeyrlkrpgvvqpnqqflfql

SAVL
 |.|
fall
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 247-504 7.4e-36 118.7 In-house 22-273 (288) alignment 
Range on Protein: 247-504
Range on HMM: 22-273/288.0
ETEYKKFDNGQQFPwEAARKPANKNKNRYANIVAYDHSRVVLErvngdEDSDYINASFIHGYDGTPRSFIASQGPLPPAFEDFWRMVWEQNSQSIVMLTN
. ||.   |. .    .    ||  ..|| |.   | .|| |.     .|.|.  |. .      .| .| .| ||  . | .|.|. |.. . ||||..
kkeyrdspneasid.iidsfianptrdryenlprcditrvkls.....ddpdfyiaanvvssakykrrlicaqaPlngtieelWkmllesdveyivmlce

LVELGKTKCHKYWPDKTE---TYGGVTVTLHQSEIFAEYEIRTFILSKAKQSGSR-MVRQFHFTVWPDKGVPQYATAVLAFRRKVRALNprdaGPVIVHC
|.|.|| |  .|.| |      .| .     ..    .  ..  .|   |.   . .|.. |.  |.|.|||.   . | .   ...|.     |..||.
llekGkeksaeyfPsklGekarigrlctvvkkkradidklvkvsllriskegeekvivkilhlleWdddgvPenylsplrllevlkslq....kPivvhs

SAGVGRTGAYIVIDAMLEQAKKSRTVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVLEALTC
||||||||. |.|  .||... .  . ||. |  ||..| . .||. || ..|  ||| |  
saGvGrtgtlililialeslrlddflgirsllaklreerfkaiqtemqylyvhrcvleelll
subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 269-507 1.3e-34 114.4 In-house 43-281 (312) alignment 
Range on Protein: 269-507
Range on HMM: 43-281/312.0
NKNKNRYANIVAYDHSRVVLervNGDEDsDYINASFIHGYdGTPRSFIASQGPLPPAFEDFWRMVWEQNSQSIVMLTNLVELGKTKCHKYWPDKTetyGG
 |. ||| ||  .|  |  |    |||.  || | |..     |  |...||||  .   ||...    | ||..|. .|| |  || ||  |     | 
fkdlnrypniqcwdrgrftl...agden.fyihanfvkic.tkperfvctqgplentcthfwqlalslgstsiillcgfvedgsekcakyisdiv...gf

vtVTLHQSEIFAEYEIRTFIL---------------SKAKQSGSRmVRQFHFTVWPDKGVPQYATAVLafrRKVRALNpRDAGPVIVHCSAGVGRTGAYI
  | | .  ...||     |                 ||    |. . .. .. |||.|.|.   . |   | . |.. .|  ||| ||||||||||. .
..vdledhrvyteycteieiggkskdkithrvlkvvvkatgqesk.lnhyqwaswpdhgmpdscdtal...rllsavk.kdkkpviahcsagvgrtgtla

VIDAMLEQAKKSRTVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVLEALTCGNT
.|..|.   .. |  .... .. |||||   |..  || .   .||| | .   
liesmiaalrhprkqnvkdsfvllrkdrarsvrvfpqyvyalrcvleflyskgl
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 253-427 4.4e-34 112.7 In-house 17-193 (297) alignment 
Range on Protein: 253-427
Range on HMM: 17-193/297.0
FDNGQQFPWEAARKPANKNKNRYANIVAYDHSRVVLERVNgdEDSDYINASFIHGY-DGTPRSFIASQGPLPPAFEDFWRMVWEQNSQSIVMLTNLVELG
.|. .   . .|....   |||| .|.|.| .|| | ||    ..||||| ..    . ..  .| .||||  . .|||..|.||. . |||...| | |
ldeargesfssakrnsslrknryrdilatddtrvkllrvi..terdyinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmvaklqedG

KTKCHKYWPDKTE--TYGGVTVTLHQSEIFAEYEIRT-FILSKAKQSGSRMVRQFHFTVWPDKGVPQYATAVLAFRRKV
. ||  |||.  .     |  |  . |.   |..      |    .| ||.||   |  |||.|||     .  |. .|
rdkcapywpsvvqerlkagdvvveflsstsdefdrviltelqliyrsesrvvrhvqflswpdhGvpsdledlvrfqaqv
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 559-795 5.9e-34 112.4 In-house 41-271 (288) alignment 
Range on Protein: 559-795
Range on HMM: 41-271/288.0
PQNLHKNRFSDIIALNSCRVMLHkehaDEESDYINAVFLHAHRGRNAFIATQHPLLETVEDFWRMVTDYDIGTIVMLNNLHELDQEY-PKYWPDHGP--T
 .|  ..|. ..   . .|| |.    |.   ||.|  . ... .. .| .| ||  |.| .|.|. . |.  ||||..| |. .|   .|.| .    .
ianptrdryenlprcditrvkls....ddpdfyiaanvvssakykrrlicaqaPlngtieelWkmllesdveyivmlcellekGkeksaeyfPsklGeka

KYGHIGVSVlsKQEQgDVICTKLKVTRKKVRRKTH---EVRHLHHVSWPDKCIPEVACSVLDLLDEAqtsqqQCGNAPVLVQCSNGVGRSGTFCAISSVL
..|..   |  |... . |   .||.  .. ....    |..||   |.|...||   | | ||.       .  . |..|..|.||||.||.  |  .|
rigrlctvv..kkkr.adidklvkvsllriskegeekvivkilhlleWdddgvPenylsplrllevl.....kslqkPivvhssaGvGrtgtlililial

ERLKTEQVIDVFQVIKRIRVNLPGAVESPTQYMFCYQIIQKYL
| |. .  . . ..... | .   |...  ||.. .... ..|
eslrlddflgirsllaklreerfkaiqtemqylyvhrcvleel
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 559-795 2.2e-33 110.6 In-house 39-277 (307) alignment 
Range on Protein: 559-795
Range on HMM: 39-277/307.0
PQNLHKNRFSDIIALNSCRVMLHKEHAdeESDYINAVFLHAHRGRNAFIATQHPLLETVEDFWRMVTDYDIGTIVMLNNLHELDQ-EYPKYWPDHGPTK-
  | .|||..|. . . .|.... . .   |||| | .|      . ||..| || .|. .|| |. . .. ...|| .. || .    .|||     | 
santdknryqdvkcqdkgrivvkfdgl..asdyihanylgiaikpkkficaqgplentqysfwamaiqekvesvimlckvielakikceqywpleegqkl

-YGH----IGVSVLS-KQEQGDVICTKLKVTRKKVRRKTHEVRHLHHVSWPDKCIPEVACSVLDLLDEAQTSQqqcgnAPVLVQCSNGVGRSGTFCAISS
 .|.    | |. |  |.   |  . ..   . .  .|.  ..||    |||. .|..  . ..||.  .  .      ||.| || |||||||  ||| 
vfgeapntisvanlgakklapdedlinvttlkvdwaqksrtiqhlqwenwpdrgvpqinltainlleavrydt.....npvvvhcsaGvGrsGtivaisl

VLERL-KTEQVIDVFQVIKRIRVNLPGAVESPTQYMFCYQIIQKYL
| ... . .   |. .... .| . . |...  ||.. .... .|.
vqdkmiaGinckdmkklveelrsqrhyaiqteaqylylhrvlleyf
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 396-534 2.4e-33 110.1 In-house 87-226 (440) alignment 
Range on Protein: 396-534
Range on HMM: 87-226/440.0
GSRMVRQFHFTVWPDKGVPQYATAVLAFRRKVRALN-PRDAGPVIVHCSAGVGRTGAYIVIDAMLEQAKKSRTVDIRNYLIALRKDRPHMVQTKEQYSFI
 || ..|.|.  |||||||..|  || . . |   .     ||..||||||.||||  |..|..| .||.|  .|| ... ..|..||.|||| |||.|.
esrtlkqyhyqgwpdkgvpkfagpvlkmiqdvnesqekagngpllvhcsagagrtgviiavdsilreakrsdqidifsfinsmrnnrpqmvqtpeqyafv

HSAVLEALTCGNTEIQSENCNQAMQKLASVNRKFQMTGYA
| ||||.| ||.| |  ..  . ....   | . . .   
heavlegllcgdtliledditerveqiqwpnphtdksplq
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 546-793 3.3e-33 109.8 In-house 18-293 (297) alignment 
Range on Protein: 546-793
Range on HMM: 18-293/297.0
REIPAEEKSVGEEPQNLHKNRFSDIIALNSCRVMLHKEHadEESDYINAVFLH--AHRGRNAFIATQHPLLETVEDFWRMVTDYDIGTIVMLNNLHELDQ
.|  .|. |.   .  |.|||. ||.| .. || | .     |.||||| ..          .| .| || .||.|||..|.. |...|||. .| |  .
deargesfssakrnsslrknryrdilatddtrvkllrvi..terdyinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmvaklqedGr

E--YPkYWPD--HGPTKYGHIGVSVLSKQ--EQGDVICTKLKVTRKkvrRKTHEVRHLHHVSWPDKCIP----EVA------CS-------VLDLLD---
.  .| |||.   .  | |.. |  ||.   |   || |.|..  .    ..  |||  ..||||. .|    ..       ||       .| |..   
dkcap.ywpsvvqerlkagdvvveflsstsdefdrviltelqliyr...sesrvvrhvqflswpdhGvpsdledlvrfqaqvcscciavpmmlalvemft

-----EAQTSQ-QQCGNAPVLVQCSNGVGRSGTFCAISSVLERLKTEQVIDVFQVIKRIRVNLPGAVESPTQYMFCYQIIQK
     . .. . ..  ||..|| || ||||||       .|..|. ... ||  ... .| . .  |..  |. ..|... |
amvflqleslraemprnayllvhcsaGvGrsGvvvlsdvilaklrkkripdvaailsilreqrarlvqtleqfellydavlk
PTPc_DSPc_SM00012 400-500 4.5e-33 109.0 In-house 2-105 (105) alignment 
Range on Protein: 400-500
Range on HMM: 2-105/105.0
VRQFHFTVWPDKGVPQYATAVLAFRRKVRALNPRDA--GPVIVHCSAGVGRTGAYIVIDAMLEQAKKS-RTVDIRNYLIALRKDRPHMVQTKEQYSFIHS
|...|.| |||.|||......| . |.|.  .   .  .||.||||||||||| ....| .|.| .|. ..||| ... .||| ||.||||.|||.|.. 
vkhyhytgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqylflyr

AVLE
|.||
alle
subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 267-502 1e-32 108.2 In-house 33-270 (285) alignment 
Range on Protein: 267-502
Range on HMM: 33-270/285.0
PANKNKNRYANIVAYDHSRVVLErvngDEDSDYINASFIHGYDGTPRSFIASQGPLPPAFEDFWRMVWEQNSQSIVMLTNLVELGKTKCHKYWPDKTE--
 || . ||||.. . . .||||.    . | ||| ||...       ..|..||||| .. |||.|.....   ..||  |.| |  ||  |.|.|    
eanpdlnryadvrcieetrvvlk....nhdrdyihaswmrmpgkdqstyittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekcalyypeklgev

-TYGGVTVTL--HQSEIFAEYEIRTFILSKAKQSGSRMVRQFHF--TVWPDKGVPQYATAVLAFRRKVRALNPRDAgPVIVHCSAGVGRTGAYIVIDAML
  .|   .||   . |  |   . .. . ..... |  .   |     |||.  |. |  .. . . |. .||..  |. |||||||||| ... ||   
vkfgkyeitlteckeeaiagtilnaltvintedasseplymnhvqvpwwpdqlapedarpmielykwvkkvnpkek.picvhcsagvgrtatfvgidyat

EQAKKSRTVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVLEAL
 .  .   ... . .  .|  | . ||.. |. |..  ..| .
irimenpniemldivremramrfqavqshmqflflyvvlmeyf
0049260 (Phosphotyrosine protein) phosphatases II 600-789 1e-32 108.3 In-house 5-144 (152) alignment 
Range on Protein: 600-789
Range on HMM: 5-144/152.0
HRGRNAFIATQHPLLETVEDFWRMVTDYDIGTIVMLNNLHELDQEYPK-YWpdhgptkyghigvsvlskqeqgdvictklkvtrkkvrrkthevrHLHHV
..  ..|||||.|. .|..|||||. ...|.|||||..|.||. .. . |.                                            . .|.
yampfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi............................................qylhl

SWPDKCIPEVACSVLDLLDEAQTSqQQCGNAPVLVQCSNGVGRSGTFCAISSVLerlkteQVIDVFQVIKRIRVNLPGAVESPTQYMFCYQ
 ||| . |. .  .|.||.  .   ..  . |||| || ||||.||..|.  .|      . ..........|   ||||..| |..|.|.
pwpDhgvpdlsqlllflllfiekl.aldkggpvlVHCsaGvgRtgtlvaaylml......lgvsleeavalvrekRpgavpnpgqlrflye
subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 600-790 3.8e-31 102.8 In-house 1-199 (199) alignment 
Range on Protein: 600-790
Range on HMM: 1-199/199.0
HRGRNAFIATQHPLLETVEDFWRMVTDYDIGTIVMLNNLHELDQ-EYPKYWP--DHGPTKYGHIGVSVLSKQEQGDVICTKLKVTRKK-VRRKTHEVRHL
|.|.  .||||||| ||. |||.|| .   | |||.|.     . .|| |||  . | .||| . |.. .   . |   | | .| .      | |. | 
hkgqrryiatqhplretmadfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishy

HHVSWPDKCIPEVACSVLDLLDEAQTS--QQQCGNAPVLVQCSNGVGRSGTFCAISSVL---ERLKTeQVIDVFQVIKRIRVNLPGAVESPTQYMFCYQI
   || .|  |.||  |  ..   . |   .|  .|||.|.||.| | .| | |.   .   |  ||  |.|.|.| ||.|    | . |  .| | ||.
qftswkekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheeskt.svvdlfevakrlrqarcgiisslqhynfiyqv
subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 602-790 1.5e-30 100.9 In-house 2-198 (198) alignment 
Range on Protein: 602-790
Range on HMM: 2-198/198.0
GRNAFIATQHPLLETVEDFWRMVTDYDIGTIVMLNNLHELDQ-EYPKYWP--DHGPTKYGHIGVSVLSKQEQGDVICTKLKVTRKK-VRRKTHEVRHLHH
|.  .||||||| ||. |||.|| .   | |||.|.     . .|| |||  . | .||| . |.. .   . |   | | .| .      | |. |   
gqrryiatqhplretladfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqf

VSWPDKCIPEVACSVLDLLDEAQTS--QQQCGNAPVLVQCSNGVGRSGTFCAISSVL---ERLKTeQVIDVFQVIKRIRVNLPGAVESPTQYMFCYQI
 || .|  |.||  |  ..   . |   .|  .|||.|.||.| | .| | |.   .   |  ||  |.|.|.| ||.|    | . |  .| | ||.
tswkekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheeskt.svvdlfevakrlrqarcgiisslqhynfiyqv
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 557-795 2.3e-30 100.4 In-house 44-287 (305) alignment 
Range on Protein: 557-795
Range on HMM: 44-287/305.0
EEPQNLHKNRFSDIIALNSCRVMLHKEHAdeeSDYINAVFLHAHRGRNAFIATQHPLLETVEDFWRMVTDYDIGTIVMLNNLHELD-QEYPKYWPDH-GP
 | |. .|||. |.  |.  || |.        .|| | .. .    . || || || .|  ||| |  .  . .| || || |   .   .|.. . ..
keaqeagknrykdvgcldnnrvklegpwp...heyihanyvstptnpkrfictqaplektcadfwymclqdkveaifmlcnllekgakkcleyfaskdkd

-TKYGHIGVSVLSKQEQGDVI----CTKLKVTR-----KKVRRKTHEVRHLHHVSWPDKCIPEVACSVLDLLDEAQTSQqqcgnAPVLVQCSNGVGRSGT
  ..   |  .  | |    .     .| |||.     .    |.. | | | . |||. .|    ..|.|| .|..|.      |. | || |.||.|.
vlefeekgqkisvkfessvtlkfrkdakakvtetvlviegpgekarkvthyhwidwpdrgvpaadlailellekarpsk.....gpivvhcsagigrtgs

FCAISSVLERLKTEQVID-VFQVIKRIRVNLPGAVESPTQYMFCYQIIQKYL
   .  .|..| . |.|.   .....|| .   .... .||.| .|.| .|.
vvmleyildqllagqiiedtdkilqkireqrnnsiqtdaqylfvhqvilnyf
subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 269-495 2.5e-30 100.3 In-house 50-274 (301) alignment 
Range on Protein: 269-495
Range on HMM: 50-274/301.0
NKNKNRYANIvAYDHSRVVLERVNGDedSDYINASFIHGYdGTPRSFIASQGPLPPAFEDFWRMVWEQNSQSIVMLTNLVELGKTKCHKYWPDKTET---
.|.|.|| ..   . |  |   |.|      | | .|    | |. |||.||||. . |||| |.   . . ||||.. ||  ..||..| | |..    
pkdkhryptv.PckPstavevivdGk..rvPihanwipts.GhphrfiatqgPlkntsedfwamlvqydvekivmlgqkvekleekceeylpvkisekld

YGGVTVTLHQSEIFAEYEI--RTFIL-SKAKQSGSRMVRQFHFTVWPDKGVPQYATAVLAFRRKVRalnpRDAGPVIVHCSAGVGRTGAYIVIDAMLEQA
 |  .......|   . .|  ||. .   ...  .| |  . .. |.|.|||.  . .  .   |.    .   |..||||||.||. |.|  . .  . 
igrfkikiknkelilnkkiskrtlevedstgkfatrtvthyqysewtdrgvPkshaelfdlmelvk....ksekPivvhcsaGiGrsvafigteylarev

KKSRTVDIRNYLIALRKDRPHMVQTKEQYSFIH
.  .|... . |  ||..| . |||..|  .. 
eadptieltealkhlrehrwngvqtnsqlywmt
PTPc_DSPc_SM00012 692-792 2.7e-30 100.0 In-house 2-104 (105) alignment 
Range on Protein: 692-792
Range on HMM: 2-104/105.0
VRHLHHVSWPDKCIPEVACSVLDLLDEAQTSQQQCG-NAPVLVQCSNGVGRSGTFCAISSVLERLKTE-QVIDVFQVIKRIRVNLPGAVESPTQYMFCYQ
|.|.|. .|||...|| . |.|.||.. ........ ..||.|.||.||||.|||.|.. .|..|..| . .|.||..|..|   ||.|.. .||.|.|.
vkhyhytgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqylflyr

IIQ
...
all
0051082 (Phosphotyrosine protein) phosphatases II 589-791 4.6e-29 96.4 In-house 3-149 (151) alignment 
Range on Protein: 589-791
Range on HMM: 3-149/151.0
SDYINAVFLHAHrgrnaFIATQHPlletVEDFWRMVTDYDIGTIVMLNNLHELDqEYPKYWPDHGptkyghigvsvlskqeqgdvictklkvtrkkvrrk
|||||. ..  .     ......|     .||.... ...| |||.|....| .  .|.|.|..|                                   
sdyinfsyvtgg.....lyrsggp....ladflellkelgiktivnlrseeerg.ycpeylpelg...................................

tHEVRHLHHVSWPDKCIPEVACSVLDLLDEAQTsqqqCGNAPVLVQCSNGVGRSGTFCAISSVLERlkteqvIDVFQVIKRIRVNLPGAVESPTQYMFCY
 .||.|.. ..|||  .|.   .||..|....     ..| |||| || |.||.||..|.  .|..      ........ .|   ||.| ...|..|..
.ievlhipildwpdpglplsfdavleflellld....kkngpvlvHCsaGkgRTGtlvalylmllg......vsleealeeyrlkrpgvvqpnqqflfql

QII
. .
fal
subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 560-789 8e-28 91.9 In-house 51-284 (310) alignment 
Range on Protein: 560-789
Range on HMM: 51-284/310.0
QNLHKNRFSDIIALNSCRVMLHKEHADeESDYINAVFLHAHRGRNAFIATQHPLLETVEDFWRMVTDYDIGTIVMLNNLHEldQEYPK---YWPDHGPTK
...||||.||.. |...|| |. ...    ||| | ....   |..|| .| ||  |. |||||. .    .|..| .  |  .  ||   |||  | |.
kymhknrysdvvcldtsrvklkidksr.yedyihanyvktnylrstficsqgplqhtiidfwrmifqeraesilllckvge..egrpkcvgywpslgvte

-YGHIGVSVLSKQEQGDVICT--------KLKVTRKKVRRKTHEVRHLHHVSWPDKCIPEVACSVLdlldeAQTSQQQCGNAPVLVQCSNGVGRSGTFCA
 || | |. ||.  .   ||         .. |  .    |   |  ..   |||. .|.  |  .      |    |    |..|.|| |..| .. .|
tygcirvtnlsesseefeicnlavtfvpdnvpvdeqpanlkelrvslikwpnwpdrgvpdekchtv.....pqrllaqvrhgpcvvhcsagkdrlyvvva

ISSVLERLKTEQVIDVFQVIKRIRVNLPGAVESPTQYMFCYQ
.   ...|.  . .|. .|.  .. .    .... ||..  .
lklkidkldrglkvdaeevktellksraiciqtelqyliidr
subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 544-793 1e-27 91.5 In-house 20-267 (281) alignment 
Range on Protein: 544-793
Range on HMM: 20-267/281.0
TSREIPAEEKSVGEEPQNLHKNRFSDIIALNSCRVMLHK-EHADEESDYINAVFLHAHRGRNAFIATQHPLLETVEDFWRMVTDYDIGTIVMLNNLHELD
   . |..  .| ..| | .|||...| .|.  || |.      . .||| | ....   .  .| || |  ||  |||||. . .  .|||| .. | .
lpgdppsdlctvfnqpvnnkknrylnipcldisrvqlkvkmpnknstdyihanyirspflkrgyiltqgpkketradfwrmiwqenttaivmlcqfletn

QEY-PKYWPD--HGPTKYGHIGVSVLSKQEQGDVICTKLKVTRKkvrRKTHEVRHLHHVSWPDKCIPEVACSVLDLLDEAQTSqqqcgNAPVLVQCSNGV
.|   .|.|   |   .. .. ||      .  .. |.|... .    .|. . |     |||  .|| .  .| .| . ..       .| ...|| ||
rekcaeyfprnahcclqfdklsvsyedstvnkslvttrlnlsye...getrlithwlwkewpdwqvpessevmlkilrkirar.....stppvihcsagv

GRSGTFCAISSVLERLKTEQV-IDVFQVIKRIRVNLP-GAVESPTQYMFCYQIIQK
|||||. |.   |. ...     |. |.. ..||     .|..  |||. ....  
grsgtlmaveialqsihshftlpdikqivshlrvtgraasvqtlqqymliwkvlld
subfamily_ptpA1_pd Subfamily ptpA1 549-755 2.4e-27 90.8 In-house 35-256 (418) alignment 
Range on Protein: 549-755
Range on HMM: 35-256/418.0
PAEEKSVGEEPQNLHKNRFSDIIALNSCRVMLHKEHADEESDYINAVFLHAHRGRnAFIATQHPLLETVEDFWRMVTDYDIGTIVMLNNLHE-LDQEYPK
   | | |.. .|  |||...|. .|  || |.| .  | |||||| ..     .  ||.|| || .|. |||||| .     ||||.   |    .  .
gpsetsegdkkhntsknrytnilpvnhtrvqlkkiqdkegsdyinanyidgaypk.qfictqgplpntiadfwrmvwenrcriivmlsresencrikcdr

YWPDH-GPTKYGHI--GVSVLS--KQEQGDVICTKLK--VT---RKKVRRKTHEVRHLHHVSWPDKCIPEVACSVLDLLDEAQTSQQQC-----GNAPVL
|||.. |  ..     |  |.     |  .||    .  .|   |  .  .|... . ..  |||. ||. .  . .||      |.|       | |..
ywpeqiggeqfsiygngnevfgtysvelveviqdpereiitrnirltfegetrditqyqyegwpdhnipdhtqpfrqllhsitnrqnqiipssdrnvpii

VQCSNGVGRSGTFCAISSVLERL
|.|| ||||.||||.   ....|
vhcsagvgrtgtfctavimmkkl
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 561-795 2.5e-27 90.3 In-house 55-289 (305) alignment 
Range on Protein: 561-795
Range on HMM: 55-289/305.0
NLHKNRFSDIIALNSCRVMLHKEHadeESDYINAVFLHAHR-GRNAFIATQHPLLETVEDFWRMVTDYDIGTIVMLNNLHELDQ-EYPKYWPDHGPTKY-
.  |||..|. . .   | |.|      |||| | .. .     . ||..| || .|...|| || .  .  |||| .  || .    .|||     |  
aitknryqdvpcqdqsavkldkps...psdyihanyvgcpmipekrficaqgpldqtidefwwmviqnkveqivmlcktvelgklkcaqywpaaqgekle

GHIGV--SVLSK----QEQGDVICTKLKVTRKkvRRKTHEVRHLHHVSWPDKCIPEVACSVLDLLDEAQTSQqqcgnAPVLVQCSNGVGRSGTFCAISSV
 . |.    .|     . . ..  | |..|      ..  ||||.   |||. .| .  . |.||   . |.      |..|.|| |.||.||  ||  .
lksgivvenvsgskpmerdaeiqitllnltys..gdqkmsvrhlqwtewpdrgvppckltslellsairgsk.....vpivvhcsagigrtgtivaieyi

LERLKTE-QVIDVFQVIKRIRVNLPGAVESPTQYMFCYQIIQKYL
||..  . ..  . ...| .| .   ....  ||.| .... .|.
lekiaenkpcppmpelvkalrdqrafsiqndvqylfihrvmlnyf
0044763 (Phosphotyrosine protein) phosphatases II 575-794 2.7e-26 87.7 In-house 4-170 (178) alignment 
Range on Protein: 575-794
Range on HMM: 4-170/178.0
SCRVMLHKEHADEESDYINAVFLHAHrgrnaFIATQHPLletvEDFWRMVTDYDIGTIVMLNNLHELD-QEYPKYWPDH-Gptkyghigvsvlskqeqgd
 .|| |..    | ||||||..   .     ......|     .|..... ...|..||.|..  ||  .....|||.  |                   
rtrvllsnleglersdyinaseilpg.....lylgslpp....addlellkelgithivnlteelelgflkcdpywpeeag...................

victklkvtrkkvrrkthevRHLHHVSWPDKCIPEVACSVLDLLDEAQTSQQQCGnAPVLVQCSNGVGRSGTFCAISSVLERlkteQViDVFQVIKRIRV
                     . .|. .|| . |..   .|....  .. ....|  |||| || |||||||..|.  ....    .. .....|...| 
....................iqylhipipDhgvpdllehflefvefieealdekg.gpvlVHCsaGvgRsgtlvaaylmkkl....gl.sleeaielvre

NLPgAVESPTQYMFCYQIIQKY
  | .|..| |. ..|.. ...
rRp.ivpnpgqlrqLyefelrl
subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 592-782 4.2e-26 86.4 In-house 78-268 (301) alignment 
Range on Protein: 592-782
Range on HMM: 78-268/301.0
INAVFLHAHRGRNAFIATQHPLLETVEDFWRMVTDYDIGTIVMLNNLHE-LDQEYPKYWPDHGPTKY--GHIGVSVLSKQE--QGDVICTKLKVTRKKVR
| | .. ..   . ||||| || .| |||| |.. ||. .|||| .  | | .   .| | . . |   |   . . .|.   . ...  .|.|.    .
ihanwiptsGhphrfiatqgPlkntsedfwamlvqydvekivmlgqkvekleekceeylpvkisekldigrfkikiknkelilnkkiskrtlevedstgk

RKTHEVRHLHHVSWPDKCIPEVACSVLDLLDEAQTSQQqcgnaPVLVQCSNGVGRSGTFCAISSVLERLKTEQVIDVFQVIKRIRVNLPGAVESPT
 .|. | |  ...|.|. .|.    . ||.. .. |..     |..|.||.|.||| .| .   .  ...... |.. . .|..| .   .|   .
fatrtvthyqysewtdrgvPkshaelfdlmelvkksek.....PivvhcsaGiGrsvafigteylareveadptieltealkhlrehrwngvqtns
subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 561-795 1.1e-25 85.2 In-house 35-270 (285) alignment 
Range on Protein: 561-795
Range on HMM: 35-270/285.0
NLHKNRFSDIIALNSCRVMLhKEHadeESDYINAVFLHA-HRGRNAFIATQHPLLETVEDFWRMVTDYDIGTIVMLNNLHELDQEY-PKYWPDHG--PTK
|   ||..|. ...  ||.| |.|   . ||| | ...   . ....|.|| || ||. |||.|. .  |  ..||  | |   |    |.|..     |
npdlnryadvrcieetrvvl.knh...drdyihaswmrmpgkdqstyittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekcalyypeklgevvk

YGHIGVSVLSKQEQG--DVICTKLKVTRkkVRRKTHEV---RHLHHVSWPDKCIPEVACSVLDLLDEAQTSqqQCGNAPVLVQCSNGVGRSGTFCAISSV
.|.  ...   .|.     |   | |.       . |     |..   |||.  || |  ...|    .    .  . |. |.|| ||||. ||  |   
fgkyeitlteckeeaiagtilnaltvin..tedasseplymnhvqvpwwpdqlapedarpmielykwvkkv..npkekpicvhcsagvgrtatfvgidya

LERLKTEQVIDVFQVIKRIRVNLPGAVESPTQYMFCYQIIQKYL
  |.  .  |....... .|     ||.|  |..| | .. .|.
tirimenpniemldivremramrfqavqshmqflflyvvlmeyf
subfamily_egg_pd Subfamily egg 556-795 1.6e-25 84.4 In-house 35-270 (307) alignment 
Range on Protein: 556-795
Range on HMM: 35-270/307.0
GEEPQNLHKNRFSDIIALNSCRVMLHKEHADEESDYINAVFLHAHRGRNAFIATQHPLLETVEDFWRMVTDYDIGTIVMLNNLHELdQEYPKYWPD--HG
  .  ||.| |   .   .|.|| |. ..     |.| |  .. .   | || .| || .||.||||||   ..  ||||.   |  .. . |||     
aasdnnlekarskrvhckdssrvklelrrGqylddfihanrvkGkpllnefilaqaplkntvddfwrmvfqeevqyivmltsrkes.erceyywpkaesd

PTKY--GHIGVSVLSKQEQGDVIctkLKVTRKKVRRKTHEVRHLHHVSWPDKCIPEVAcSVLDLLDEAQTSqqqcgNAPVLVQCSNGVGRSGTFCAISSV
. ..  | . .  |  ... | .   ..||. |.    .| |.| |  .  .   .|  | | .|  ..         ||.||. .|| ...|. ||   
slvtvpGslrienlkvdskadpl...frvtklklvGgddeerflehwqgdvnnssdvy.splrvlrklrnl.....skpvvvqdilGvskaatlvaieia

LERLKTEQV--IDVFQVIKRIRVNLPGAVESPTQYMFCYQIIQKYL
|  |    .    | . .. .| . . .|||. .|.| |...  ..
llsllrGpitkslvlravvflrlrrrlsvesvllylfvyrlvlfff
0048076 (Phosphotyrosine protein) phosphatases II 367-499 5.8e-25 83.1 In-house 14-140 (145) alignment 
Range on Protein: 367-499
Range on HMM: 14-140/145.0
GGVTvTLHQSEIFAEYEIRT-FILSKAKQSGSRMVRQFHFTVWPDKGVPQYATAVLAFRRKVRALNPRDaGPVIVHCSAGVGRTGAYIVIDAMLEqakks
|... | .. | .... |.| . |.  ..  .|.. |.... ||| |||. .  .|.| . .... ... |||.|||||||||||...... ||.     
gslp.taldlellkdlgittvlnltselellerlgiqylylpwpDhgvpdllellleflefieealkeg.gpvlVHCsaGvgRtgtlvaaylmll.....

RTVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVL
. |.. . |  .|. ||..|.. .|. |.. ..|
lgvsleealelvrsqrpgavpnpgqlrflyefel
subfamily_egg_pd Subfamily egg 258-499 1e-24 81.8 In-house 29-267 (307) alignment 
Range on Protein: 258-499
Range on HMM: 29-267/307.0
QFPWEAARKPANKNKNRYANIVAYDHSRVVLERVNGDEDSDYINASFIHGYDgTPRSFIASQGPLPPAFEDFWRMVWEQNSQSIVMLTNLVELgkTKCHK
. . . | .  |..| |   .   | ||| ||  .|    |.| |  ..|       || .| ||  . .||||||.... | |||||  .|    .|. 
eislttaasdnnlekarskrvhckdssrvklelrrGqylddfihanrvkGkp.llnefilaqaplkntvddfwrmvfqeevqyivmltsrkes..ercey

YWPDKtETYGGVT--VTLHQSEiFAEYE--IRTFILSKAKQSGSRmVRQFHFTVWpdKGVPQYATAVLAFRRKVRALNpRDAGPVIVHCSAGVGRTGAYI
|||   |.   ||   .|.    .  ..     | ..| |  |.    . .   |  .|  .... |    | .| |  . . ||.|..  || .... .
ywpka.esdslvtvpGslrien.lkvdskadplfrvtklklvGgd.deerflehw..qgdvnnssdvysplrvlrklr.nlskpvvvqdilGvskaatlv

VIDAMLEQAKKSRT--VDIRNYLIALRKDRPHMVQTKEQYSFIHSAVL
 |.  | .  .  .    ...    ||. |.  |..  .| |..  ||
aieiallsllrGpitkslvlravvflrlrrrlsvesvllylfvyrlvl
0048179 (Phosphotyrosine protein) phosphatases II 382-496 7.7e-24 79.5 In-house 28-139 (144) alignment 
Range on Protein: 382-496
Range on HMM: 28-139/144.0
YEIRTF---ILSKAKQSGSRMVRQFHFTVWPDKGVPQYATAVLAFRRKVRALNPRDaGPVIVHCSAGVGRTGAYIVIDAMLeqakkSRTVDIRNYLIALR
. |.|    . .  ...  |.. |.... ||| |||.... .|.| . .... ... |||.|||||||||||...... |.      . ... . |  .|
lgittvinlteeyepefleregiqylhlpwpDhgvpdllellleflefieealeeg.gpvlVHCsaGvgRtgtlvaaylmk.....klglsleealalvr

KDRPHMVQTKEQYSFIHS
. ||..|.. .|. |.. 
srrpgavpnpgqlrfLle
subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 313-495 1.1e-23 78.5 In-house 5-197 (199) alignment 
Range on Protein: 313-495
Range on HMM: 5-197/199.0
RSFIASQGPLPPAFEDFWRMVWEQNSQSIVMLTNLVELGKTKCHKYWPD---KTETYGGVTVTLHQSEIFAEYEIRTFILSKAKQ--SGSRMVRQFHFTV
| .||.| ||  .. |||.||||  |  |||. .     ..    |||     |  || ..|| .     ..| | ..||..       .| . .. || 
rryiatqhplretmadfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqfts

WPDKGVPQYAT---AVLAFRRKVRALNPRDAGPVIVHCSAGVGRTGAYIVIDAMLEQAKKSRT--VDIRNYLIALRKDRPHMVQTKEQYSFIH
| .|  |. |     |.| |   .  .     ||||||| | | || .. .|  .   ..|.|  ||. .    ||. |  .. . ..| ||.
wkekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiy
subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 313-495 1.2e-23 78.4 In-house 4-196 (198) alignment 
Range on Protein: 313-495
Range on HMM: 4-196/198.0
RSFIASQGPLPPAFEDFWRMVWEQNSQSIVMLTNLVELGKTKCHKYWPD---KTETYGGVTVTLHQSEIFAEYEIRTFILSKAKQ--SGSRMVRQFHFTV
| .||.| ||  .. |||.||||  |  |||. .     ..    |||     |  || ..|| .     ..| | ..||..       .| . .. || 
rryiatqhplretladfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqfts

WPDKGVPQYAT---AVLAFRRKVRALNPRDAGPVIVHCSAGVGRTGAYIVIDAMLEQAKKSRT--VDIRNYLIALRKDRPHMVQTKEQYSFIH
| .|  |. |     |.| |   .  .     ||||||| | | || .. .|  .   ..|.|  ||. .    ||. |  .. . ..| ||.
wkekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiy
subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 267-499 2.5e-23 77.0 In-house 49-282 (302) alignment 
Range on Protein: 267-499
Range on HMM: 49-282/302.0
PANKNKNRYANIVAYDHSRVVLERvngdEDSDYINASFIHGYDGTpRSFIASQGPLPP---AFEDFWRMVWEQNSQSIVMLTNLVELGKtKCHKYWPDKT
 .| .||.  .. ..|. .| ||     |  .|.||| ..  . | || | .| |      . |.|||||.... .|.|.|    || |   ....| |.
kknlkknqsedvpildsnlvklea....epdsyvnaskvevPelt.rsiilaQlpkvdsedsveeFWrmvfqekivsvvilvgeeelkk.tlselfpkks

ET---YGGVTVTLHQSEIFAEYEiRTFIL--SKAKQSGSRMVRQFHFTVWPDKGVPQYATAVLAFRRKVRALNPRDAGPVIVHCSAGVGRTGAYIVIDAM
..   || . |   . |   | .   ...       | | ..   ..| |..| ||.  ... .   || |..     ....    |.|| || ..  . 
gdykeygkmfvNnrkVekaeeek.tryviEvlPegcsnsvlanvyvltnWkqkkvpvkyaeliktaakvfakkikadentvivSknGaGRagafltlava

LEQAKKSRTVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVL
.|. .|.  . | . ....|..||..|.. .|| ... |.|
veklqkgkepnikeivksiRsqRpravdslkQyvslyiall
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 271-374 1.7e-22 74.6 In-house 49-163 (350) alignment 
Range on Protein: 271-374
Range on HMM: 49-163/350.0
NKNRYANIVAYDHSRVVLER--------VNGDEDSDYINASFIHGY----DGTPRS-FIASQGPLPPAFEDFWRMVWEQNSQSIVMLTNLVELGKTKCHK
 |||| ||. |.|||| |..            . .|||||....      .  |   .|| |.||| ...||.... . . . |..||..|||.  ||..
aknrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvkvilsltsdvelnlekcyr

YWPDKteTYGGVTVTLH
||..   .| ..|| | 
YWqeg..sydditvkla
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 691-792 2.8e-21 70.3 In-house 90-191 (440) alignment 
Range on Protein: 691-792
Range on HMM: 90-191/440.0
EVRHLHHVSWPDKCIPEVACSVLDLLDEAQTSQQQCGNAPVLVQCSNGVGRSGTFCAISSVLERLKTEQVIDVFQVIKRIRVNLPGAVESPTQYMFCYQI
 ... |. .|||| .|..|  || .... . ||...||.|.||.|| |.||.|   |. |.|   |  . ||.| .|. .| | |  |..| || | .. 
tlkqyhyqgwpdkgvpkfagpvlkmiqdvnesqekagngpllvhcsagagrtgviiavdsilreakrsdqidifsfinsmrnnrpqmvqtpeqyafvhea

IQ
. 
vl
subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 613-794 2.2e-20 67.8 In-house 39-220 (255) alignment 
Range on Protein: 613-794
Range on HMM: 39-220/255.0
LleTVEDFWRMVTDYDIGTIVMLNNLHEL-DQEYPKYWPDHGPTKYGHIGVSVLSKQEQGDVICTKLKVTRKKV-RRKTHEVRHLHHVSWPDKCIPEVAC
|  ||. |....   .  ..||| ...|   ..  .|.|     |     |.| . .   ||.   |..| .   ..|||.|.| ..  |..|  || | 
l..tvdkfyqtivqtktevvvmlcdfaeegvekcssyfplekdeklkladvnvtttkssadvvlrtleitstlgekkkthtvkhysykGWieknaPelar

SVLDLLDEAQTSQqqcgnaPVLVQCSNGVGRSGTFCAISSVLE----RLKTEQV--IDVFQVIKRIRVNLPGAVESPTQYMFCYQIIQKY
 .| .|  .. |.      .|.|.||.|.||| .|  . .|       |.| .   .|  .... .| . ..|.. | |  |.  .. ..
eilnilkvvrdsk......svvvhCstGiGrsaafvlaelvyqkmirsldttetveldylslleelrskrkraihtPlqlafsilmvldl
subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 325-506 2.4e-20 67.7 In-house 40-222 (255) alignment 
Range on Protein: 325-506
Range on HMM: 40-222/255.0
AFEDFWRMVWEQNSQSIVMLTNLVELGKTKCHKYWP---DKTETYGGVTVTLHQseIFAEYEIRTFILS--KAKQSGSRMVRQFHFTVWPDKGVPQYATA
. . |....  .... .|||... | |. ||..|.|   |.   .  |.||  .    |.  .||  .    ...   . |. .... |..|  |. |  
tvdkfyqtivqtktevvvmlcdfaeegvekcssyfplekdeklkladvnvtttk..ssadvvlrtleitstlgekkkthtvkhysykGWieknaPelare

VLAFRRKVRalnprDAGPVIVHCSAGVGRTGAYIVIDAM----LEQAKKSRTVDI--RNYLIALRKDRPHMVQTKEQYSFIHSAVLEALtcgN
.|   . ||     |. .|.||||.|.||. |..... .    . . ... ||..  .. |  ||. |.  ..|  | .|    ||. .    
ilnilkvvr.....dsksvvvhCstGiGrsaafvlaelvyqkmirsldttetveldylslleelrskrkraihtPlqlafsilmvldlv...f
subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 272-521 7.6e-20 66.2 In-house 22-279 (290) alignment 
Range on Protein: 272-521
Range on HMM: 22-279/290.0
KNRYANIVAyDHSRVVLERVNGDEDSDYINASFIHGYDGTprSFIASQGPLPPA-------FEDFWRMVWEQNSQSIVMLTNLVELGKT----KCHKYWP
..|... ..  ..||||.       .||| |...   .|    .|..| |.           |.|| |. . .....||| .  |  .      | || |
dqRlevpLv.eatrvvLkgygkrfnddyiHAnrvtcpngl..rliltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCakYvp

DKTE---TYGGVTVTLHQSEIFAEYEIRTFILSKAKQSgSRMVRQFHFTVWPDKGVPQYATAVLAFRRKVRalnpRDAGPVIVHCSAGVGRTGAYIVIDA
.. .   ...|.||   . |   . |.|. ..   ..     |    .  | .  |..    .|.  .||.        ||||||  |. |  |   |. 
esvgeelkfkgltvkCkskekeddvetRelvvkfddee.eftvtHsllkgWnklnvqedtktllsliqkvk....asktpvivHcvdGiSrsAalaaiil

MLE-QAKKSRTVDIRNYLIALRKDRPHMVQTKEQYSFIHSAV-LEALTCGNTEIQSENCNQAMQKL
     |..|  | ... | |||| | ..........|.  .. | |   ... ...|. ..|... 
gyQkiaetsgsvkledvlkalrkqralaitsalelafvdagivllaievldqfaeeetekkakaee
subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 560-795 1.5e-19 64.5 In-house 50-285 (302) alignment 
Range on Protein: 560-795
Range on HMM: 50-285/302.0
QNLHKNRFSDIIALNSCRVMLHKEhadeESDYINAVFLHAHRGRNAFIATQHPLLETV---EDFWRMVTDYDIGTIVMLNNLHELDQEYPKYWPD--HGP
.||.||.  |. .|.| .| |..|    . .|.||  ..    ..  | .| | ....   |.||||| .  | ..|.|    ||..   ...|      
knlkknqsedvpildsnlvkleae....pdsyvnaskvevPeltrsiilaQlpkvdsedsveeFWrmvfqekivsvvilvgeeelkktlselfpkksgdy

TKYGHIGVSVL---SKQEQGdvICTKLKVTRKKVRRK-THEVRHLHhvSWPDKCIPEVACSVLDLLDEAqTSQQQCGNAPVLVQCSNGVGRSGTFCAISS
..||.. | .    ...|.       . |  . .      .| .|.   |..| .|.   ..     .    ... .......   ||.|| |.| .   
keygkmfvNnrkVekaeeek..tryviEvlPegcsnsvlanvyvlt..nWkqkkvpvkyaeliktaakv.fakkikadentvivSknGaGRagafltlav

VLERLKTEQVIDVFQVIKRIRVNLPGAVESPTQYMFCYQIIQKYL
..|.|....   . ...| || . | ||.| .||.. | ..  |.
aveklqkgkepnikeivksiRsqRpravdslkQyvslyialllyi
0048076 (Phosphotyrosine protein) phosphatases II 682-794 3.6e-19 64.3 In-house 37-142 (145) alignment 
Range on Protein: 682-794
Range on HMM: 37-142/145.0
RKKVRRKTHEVRHLHHVSWPDKCIPEVACSVLDLLDEAQTSQQQcgNAPVLVQCSNGVGRSGTFCAISSVLErlktEQvIDVFQVIKRIRVNLPGAVESP
    .  .... ......||| ..|. .  .|..|.  .. ...  . |||| || ||||.||..|.  .|.    .. ..........|   ||||..|
tselellerlgiqylylpwpDhgvpdllellleflefieealke..ggpvlVHCsaGvgRtgtlvaaylmll....lg.vsleealelvrsqrpgavpnp

TQYMFCYQIIQKY
 |. |.|. ....
gqlrflyefelel
0048179 (Phosphotyrosine protein) phosphatases II 672-789 6.7e-19 63.5 In-house 48-139 (144) alignment 
Range on Protein: 672-789
Range on HMM: 48-139/144.0
DvictklkvtrkkvrrktheVRHLHHVSWPDKCIPEVACSVLDLLDEAQTSQQqcGNAPVLVQCSNGVGRSGTFCAISsvleRLKTEQvIDVFQVIKRIR
                    . ...|..||| ..|. .  .|..|.  .. ..   . |||| || ||||.||..|.     ..|... ..........|
e...................giqylhlpwpDhgvpdllellleflefieeale..eggpvlVHCsaGvgRtgtlvaay....lmkklg.lsleealalvr

VNLPGAVESPTQYMFCYQ
   ||||..| |..|...
srrpgavpnpgqlrfLle
subfamily_hpo-7_pd Subfamily hpo-7 608-791 8.4e-19 62.5 In-house 42-223 (263) alignment 
Range on Protein: 608-791
Range on HMM: 42-223/263.0
AtqhpLLETVEDFWRMVTDYDIGTIVMLNNLHEL-DQEYPKYWPDHGPTKYGHIGVSVLSKQEQGDVICTKLKVTRK--KvRRKTHEVRHLHHVSWPDKC
     |..|.. |....      ..||| . .|   ..  .|.|     |     |.| . . | ||.   |...    . ..|||.|.|  .. |..| 
l....lvqtidkfyqtivqtktevvvmLcDfneegvekcssyfPlekdekqklanvnvcttkvqsdvllktlellstlge.KkkthtvkhysykgWiekn

IPEVACSVLDLLDEAQTSQqqcgnaPVLVQCSNGVGRSGTFCAISSVLE----RLKTEQV--IDVFQVIKRIRVNLPGAVESPTQYMFCYQII
 || | ..| .|. |. |.      .. | ||.|.|||  |  . .|       |.| .   .|  .... .| . ..|.. | |  |   ..
dpelareilnilkvarnsk......slvvhcstGiGrsaafsvaElvyqkmirsldttstveldylsLleelrssrkraihtPmqLafsilmv
subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 611-794 1.2e-18 61.6 In-house 98-287 (302) alignment 
Range on Protein: 611-794
Range on HMM: 98-287/302.0
HPLLETVEDFWRMVTDYDIGTIVMLNNLHELD-QEYPKYWPDH--GPTKYGHIGVSVLSKQEQGDVICT-------KLKVTRKKVRR-KTHEVRHLHHVS
 |  .|.| .| .. .|... .| | .. | . . . .|. |.  |  |.|.  |  .| ... .           ..... .|... . . |  |.. .
vpkkstlekhwalieqynvaivvqlcsfvedeekkcaeyysdkvggelkfgrytvktvsvktdleeftdkksfklytveiknekkkkkvkktvdilafsa

WPDKCIPEVACSVLDLLDEAQTSQQQcgnapVLVQCSNGVGRSGTFCAISSVLERLKTEQVIDVFQVIKRIRVNLPGAVESPTQYMFCYQIIQKY
|||.  |. | . ||.|   .. ...     ||| ||.||||.||. ||   ..  ....| |. .... .|    ||| . .| ..   .. | 
wpdhGapkeaytaldilkfcesykkn.....vlvhcsaGvGrtGtlvaikyGiqlcskkkvtdllsivlpvrqcryGavqdeqqliylllcvtkg
subfamily_CG42327_pd Subfamily CG42327 562-722 1.6e-18 61.5 In-house 29-193 (319) alignment 
Range on Protein: 562-722
Range on HMM: 29-193/319.0
LHKNRFSDIIALNSCRVMLHKEHADEESDYINAVFLHAHR-GRNAFIATQHPLLETVEDFWRMVTDYDIGTIVMLNNLHELD-QEYPKYWPDH----GPT
  |.|. ... |   ||.|..   |... |..| ..  ..  .| .||.| .| ..  ||||.| .    .|| | .|.||  .  ..|.| .    .  
kdksrvinvvPlPetrvvlqrigdddkdeyldasyvrGyddapnsyiaaqvsledsssdfwrtvweqqsrvivqltdlselGikvcaeylPtketldnts

KYGHIGVSvLSKQEQGDVICTKLKVTRKKVRRKTHEVRHLHHvSWPDKCIPEVACSVLDLLDEAQTS
 ||.| |. | ..| .|   .   . ..  . .. |. |  .  |..  .|    ... .| |...|
lyGdilvt.lkgrevkdryaistlllkrvdkeesrelthywy.kwleaevPaeeaaliamllevrss
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 545-653 7e-18 59.5 In-house 31-154 (350) alignment 
Range on Protein: 545-653
Range on HMM: 31-154/350.0
SREIPAEEKSVGEEPQNLHKNRFSDIIALNSCRVMLH--------KEHADEESDYINAVFLHAH----RGRNAF--IATQHPLLETVEDFWRMVTDYDIG
. | | ..  . |  .   |||...|.  .  || |.        |.|. . .||||| .|.      .    |  |||| || .||.||.....  .. 
dsespsnDvilseGvelfaknrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvk

TIVMLNNLHELDQE-YPKYWPDHG
 |..|... ||. | . .||.. .
vilsltsdvelnlekcyrYWqegs
subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 573-791 8.1e-18 59.6 In-house 30-255 (290) alignment 
Range on Protein: 573-791
Range on HMM: 30-255/290.0
LNSCRVMLHKEHADEESDYINAVFLHAHRGRnAFIATQHPLLET-------VEDFWRMVTDYDIGTIVMLNNLHELDQEY-----PKYWPDHGP--TKYG
..  ||.|.       .||| | ..    |  ..|.|| |. ..       .|.|| |. .  .  .||| . .| ...       || |..     |..
veatrvvLkgygkrfnddyiHAnrvtcpngl.rliltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCakYvpesvgeelkfk

HIGVSVLSKQEQGDVICTKLKVTRKKvrRKTHEVRHLHHVSWPDKCIPEVACSVLDLLDEAQtsqqqCGNAPVLVQCSNGVGRSGTFCAISSVLERLK-T
 . |.  || .. ||.  .| |.  .  .. . | |   ..| .  ..|   ..|.|..  .     . ..||.| | .|. || .. ||      .  |
gltvkCkskekeddvetRelvvkfdd..eeeftvtHsllkgWnklnvqedtktllsliqkvk.....asktpvivHcvdGiSrsAalaaiilgyQkiaet

EQVIDVFQVIKRIRVNLPGAVESPTQYMFCYQII
.. . . .|.| .| .   |. |.... |    |
sgsvkledvlkalrkqralaitsalelafvdagi
subfamily_hpo-7_pd Subfamily hpo-7 325-537 9.6e-18 59.0 In-house 46-260 (263) alignment 
Range on Protein: 325-537
Range on HMM: 46-260/263.0
AFEDFWRMVWEQNSQSIVMLTNLVELGKTKCHKYWP---DKTETYGGVTVTLHQSEIfaEYEIRT----FILSKakQSGSRMVRQFHFTVWPDKGVPQYA
. . |....  .... .|||..  | |. || .|.|   |.   .  |.|.  ..    .  ..|     .|..  .   . |... .. |..|  |. |
tidkfyqtivqtktevvvmLcDfneegvekcssyfPlekdekqklanvnvcttkvqs..dvllktlellstlge..KkkthtvkhysykgWiekndpela

TAVLAFRRKVRalnprDAGPVIVHCSAGVGRTGAYIVIDA----MLEQAKKSRTVDI--RNYLIALRKDRPHMVQTKEQYSFIHSAVLEALTCGNTEIQS
  .|   . .|     .  ...||||.|.||. |. |..     |. . ... ||..  .. |  ||. |.  ..|  | .|    ||. .   ... . 
reilnilkvar.....nskslvvhcstGiGrsaafsvaElvyqkmirsldttstveldylsLleelrssrkraihtPmqLafsilmvLdfvlnnfakgel

ENCNQAMQKlaSVNRKFQMTGYALEF
|   | ..|  |  .  ||    |||
eakyqeirk..sylharqmmhkdlef
subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 268-502 1.5e-17 58.2 In-house 46-279 (303) alignment 
Range on Protein: 268-502
Range on HMM: 46-279/303.0
ANKNKNRYANIVAYDHSRVVLervngdEDSDYINASFIHgYDgTPRSFIASQGPLPPAFEDFWRMVWEQNSQSIVMLTNLVELGKTKCHKYWPDKTETYG
 | .|||.....  |||.| |       || || ||...  | . .  | .| ||. .  |||.|. ||. . ...|    |  |   .  .| . .   
knmdknrfvdvicldhskvkl......sdssyihasyle.ld.sskkailtqlplshtaadfwqmiieqkvkcvlllltdseydklggdsvfprnqdflk

G----VT-VTLHQSEIFAEYEIRTFILSKakQSGSRMVRQFHFTVWPDKGVPQY-----ATAVLAFRRKVRALnpRDAGPVIVHCSAGVGRTGAYIVID-
     .    ... |.   . ..   .|.   .   ..   |.  || . .|          .   .  .|     |. | .    .|.||.|.. ... 
feersirvgefkrvelgdgwvlkvlsvsn..gdyksflhvhhykawphnsipsdgspkfvkqiwqlqsvlrky..sdstptvymslsgcgragtfalfet

AMLEQAKKSRTVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVLEAL
| |   ..  ..|. . |  .|. | | ||   |.|.... . | .
ahlslhseqasldlvkclenvrngrlhavqnlsqfsvvytllaehv
subfamily_eak_pd Subfamily eak 253-427 1.8e-17 57.8 In-house 35-207 (332) alignment 
Range on Protein: 253-427
Range on HMM: 35-207/332.0
FDNGQQFPWE-AARKPANKNKNrYANIVAYDHSRVVLERVNGDEDsDYINASFIHgYDGTPRSFIASQGPLPPAFEDFWRMVWEQNSQSIVMLTNLVELG
.|. |.   .  ...  . |.|   .|| ||.  | |     ...  ||||| .  .    | .| .  .       ||.|| ||.| .||.| . |||.
lddyqrllsisetarleavnrn.vvkivpydrylvrltssqlnrl.Gyinaslae.fsevGrkyiltGiasedkvfafwqmvleqkspaivqlledvelk

KTKCHKYWPDKT---ETYGGVTVTLHQSEIFAEYEIRTFILSKAKQsgSRMVRQFHFTVWPDKGVPQYAtAVLAFRRKV
  |  ||.||||     .| . |.  .    . .| | ..|||  .  .  |  ...  | .  .|.|    ||.|. .
leksdkyfpdktreelkfGildverkefvkrniletrllelskGne..thrvlhykvfGwtettlpkye.dflalrkvm
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 426-502 2.3e-17 57.8 In-house 220-295 (297) alignment 
Range on Protein: 426-502
Range on HMM: 220-295/297.0
KVRALNPRDAgPVIVHCSAGVGRTGAYIVIDAMLEQAKKSRTVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVLEAL
 .||  ||.| ...|||||||||.|  .  |..|.. .| |  |..  |  ||. |. .||| ||. ....|||. |
slraemprna.yllvhcsaGvGrsGvvvlsdvilaklrkkripdvaailsilreqrarlvqtleqfellydavlkkl
subfamily_CG42327_pd Subfamily CG42327 433-497 3.9e-17 56.9 In-house 245-310 (319) alignment 
Range on Protein: 433-497
Range on HMM: 245-310/319.0
RDAGPVIVHCSAGVGRTGAYIVIDAMLEQAKKS-RTVDIRNYLIALRKDRPHMVQTKEQYSFIHSA
 . ||..|||| ||||||  |  |  ... ..| |.||| . .  .|.|| . |.||||| ||.  
esqGPlvvhcsdGvGrtGlviasdiairsleeskrsvdiPqlvssvrrdrasavltkeqyefiykv
subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 325-501 4.1e-17 56.6 In-house 103-287 (302) alignment 
Range on Protein: 325-501
Range on HMM: 103-287/302.0
AFEDFWRMVWEQNSQSIVMLTNLVELGKTKCHKYWPDKTE---TYGGVTVTLHQ-S---EIF------AEYEIRtFILSKAKQSGSRMVRQFHFTVWPDK
. | .| .. . |   .| |...|| .. || .|. || .   ..|  ||.  .     | |        | .  .  .| |.   . |  ..|. |||.
tlekhwalieqynvaivvqlcsfvedeekkcaeyysdkvggelkfgrytvktvsvktdleeftdkksfklytve.iknekkkkkvkktvdilafsawpdh

GVPQYATAVLAFRRKVRALNPRdagpVIVHCSAGVGRTGAYIVIDAMLEQAKKSRTVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVLEA
| |. | . |   .   .        |.|||||||||||. . |   ..  .| .. |. . .. .|. |   ||...|  ..   |  .
Gapkeaytaldilkfcesykkn....vlvhcsaGvGrtGtlvaikyGiqlcskkkvtdllsivlpvrqcryGavqdeqqliylllcvtkg
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 224-309 6.4e-17 56.0 In-house 4-87 (440) alignment 
Range on Protein: 224-309
Range on HMM: 4-87/440.0
KPIPIALFPEYVAKMQANggIRLETEYKKFDNGQQFPWEAARKPANKNKNRYANIVAYDHSRVVLERVNGDEDSDYINASFIHGYD
.|| .| | .|| . .       | |.  . .| . | . |  | || |||| ||.|||||||.|| |.|  ||||||||.| | .
rpiivadfadyvqnnrrs..rafedewsllpsglsqpsdiaslpnnkvknryrnilaydhsrvmleevkgvpdsdyinasyingie
subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 559-794 7e-17 56.0 In-house 45-278 (303) alignment 
Range on Protein: 559-794
Range on HMM: 45-278/303.0
PQNLHKNRFSDIIALNSCRVMLHkehadeESDYINAVFLHAHRGRNAfIATQHPLLETVEDFWRMVTDYDIGTIVMLNNLHELDQE-----YPKYwPDHG
 .|..|||| |.| |.  .| |       .| || | .|. .  ..| | || ||  |  |||.|. .  .  ...|    | |.      .|.   |  
vknmdknrfvdvicldhskvkls......dssyihasyleldsskka.iltqlplshtaadfwqmiieqkvkcvlllltdseydklggdsvfprn.qdfl

PTKYGHIGVSVLSKQEQGDVICtkLKVTRKKVrRKTHEVRHLHHV-SWPDKCIPEV-ACSVLDLLDEAQTSQ-QQCGNAPVLVQCSNGVGRSGTFCAISS
  .   | |  . . | ||     |||       . .   |.||  .|| . ||   .  ..  . . |.   . . . | .     |.||.|||. . .
kfeersirvgefkrvelgdgwv..lkvlsvsn.gdyksflhvhhykawphnsipsdgspkfvkqiwqlqsvlrkysdstptvymslsgcgragtfalfet

VLERLKTEQV-IDVFQVIKRIRVNLPGAVESPTQYMFCYQIIQKY
    |..||  .|. .... .|     ||.  .|. . | .. ..
ahlslhseqasldlvkclenvrngrlhavqnlsqfsvvytllaeh
subfamily_Sponge-PTP-7_pd Subfamily Sponge-PTP-7 439-505 1.6e-16 54.5 In-house 2-68 (69) alignment 
Range on Protein: 439-505
Range on HMM: 2-68/69.0
IVHCSAGVGRTGAYIVIDAMLEQAKKSRTVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVLEALTCG
.||||.| ||||..| |   . . |  . ||| | .  .|| || ||  . .| ||| |. |||  |
vvhcssgtgrtgtfiaimvemarikseklvdifnnvqymrkcrpmmvmneieyifihdalvealklG
subfamily_Sponge-PTP7_pd Subfamily Sponge-PTP7 439-505 2.4e-16 53.8 In-house 1-67 (69) alignment 
Range on Protein: 439-505
Range on HMM: 1-67/69.0
IVHCSAGVGRTGAYIVIDAMLEQAKKSRTVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVLEALTCG
.||||.| ||||..| |   . . |  . ||| | .  .|| || ||  ...| ||| |. |||  |
vvhcssGtGrtGtfiaimvemarikseklvdifnnvqymrkcrpmmvmneneymfihdalvealklG
subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 565-801 3.8e-16 53.7 In-house 47-282 (312) alignment 
Range on Protein: 565-801
Range on HMM: 47-282/312.0
NRFSDIIALNSCRVMLhkehADEESDYINAVFLHAHRGRNAFIATQHPLLETVEDFWRMVTDYDIGTIVMLNNLHELDQE-YPKYWPDHG-PT------K
||. .|   .  |  |    | .|  || | |..     . |..|| || .|.  ||...      .|..|  . |   |   ||  |            
nrypniqcwdrgrftl....agdenfyihanfvkictkperfvctqgplentcthfwqlalslgstsiillcgfvedgsekcakyisdivgfvdledhrv

YGHIGVSVLSKQEQGDVIC-TKLKVTRKKVrRKTHEVRHLHHVSWPDKCIPEVACSVLDLLDEAQTSqqqcgNAPVLVQCSNGVGRSGTFCAISSVLERL
|      .       | |    |||  |    .   . |    ||||. .|.   . | ||   .       . ||. .|| ||||.||.. | |..  |
yteycteieiggkskdkithrvlkvvvkat.gqesklnhyqwaswpdhgmpdscdtalrllsavkkd.....kkpviahcsagvgrtgtlaliesmiaal

KTEQVIDVFQVIKRIRVNLPGAVESPTQYMFCYQIIQKYLDSFSDY
.  .  .| ..   .| .   .|.   ||... ... ..| | . |
rhprkqnvkdsfvllrkdrarsvrvfpqyvyalrcvleflyskgly
subfamily_Sponge-PTP3_pd Subfamily Sponge-PTP3 224-320 4.5e-15 49.6 In-house 3-95 (95) alignment 
Range on Protein: 224-320
Range on HMM: 3-95/95.0
KPIPIALFPEYVAKMQANGGIRLETEYKKFDNGQQFPWEAARKPANKNKNRYANIVAYDHSRVVLErvnGDEDSDYINASFIHGYDGTpRSFIASQG
||| ...|  .| .|..|    .. |.|        |. .    ||  |||. ||. || .||||       ||||||| |. ||      .||.||
kpihvsvfhshvlemhsnsdqefdnefksismtsgapytvgsseanipknrflnifpydatrvvlt...tkrdsdyinacfvdgyark.ncyiaaqg
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 602-694 1.3e-14 48.4 In-house 234-322 (440) alignment 
Range on Protein: 602-694
Range on HMM: 234-322/440.0
GRNAFIATQHPLLETVEDFWRMVTDYDIGTIVMLNNLHelDQEYPKYWPDHgpTKYGHIGVSVLSKQEQGDVICTKLKVTRKKVRRKTHEVRH
 .||||||| ||  || ||||.| || | ||.|||.|   |.    |||    |.   .|   . ..   ..   |..    | . . ||.| 
kknafiatqmpldstvldfwrlvhdyristiimlnqln..dktcsiywpvn..trsvtfgpftvghkgsenmnrvkvrtlelkykeevheirq
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 271-377 3.3e-14 47.0 In-house 50-169 (349) alignment 
Range on Protein: 271-377
Range on HMM: 50-169/349.0
NKNRYANIVAYDHSRVVLERVN--------------GDEDSDYINASFIHGYDGTP-RSFIASQGPLPPAFEDFWRMVWEQNSQSIVMLTNLVELGKTKC
 |||| .|. |.||||.|..                .    ||||| ...    .. . .|| | ||| . .||....  .. . .. |..  ||.  ||
aknrykdilPyehsrvklkkslksskvikastsesdsgklddyinanylkltrisvekkyiatqaPlPstvddfykvillngvklvlsLnddkelslekc

HKYWPDKteTYGGVTVTLHQSE
..|| .   .| ..|| |  | 
diywqel..sysnitvklqnss
subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 557-672 6.3e-14 46.2 In-house 92-203 (244) alignment 
Range on Protein: 557-672
Range on HMM: 92-203/244.0
EEPQNLHKNRFSDIIALNSCRVMLHKEHAdeESDYINAVFLHAHRGRNAFIATQHPLLETVEDFWRMVTDYDIGTIVMLNNLHELDQeypkYWPDHGPTK
 .|.| .||| .  . ..  || | |        |||| |.        .| ||||| .|  |||.|. .  .  .|.|  . | |.    ||||  | .
fnpnnswknregaglpfdfnrvplskgsm..gntyinasfvgclgrtaeyiltqhpladtsmdfwkmmlerhvnvlvvlgsveeede....ywpdseple

YG--HIGVSVLSKQEQGD
.    | |..  ..|  .
wyeeditvtltdrdefkn
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 433-499 4.4e-13 43.7 In-house 260-341 (350) alignment 
Range on Protein: 433-499
Range on HMM: 260-341/350.0
RDAGPVIVHCSAGVGRTGAYIVIDAMLE-------QAKKSRTVDIRN--------YLIALRKDRPHMVQTKEQYSFIHSAVL
  . |..||||||||||| .. .| .|.         |.|| .|  .         .  ||| |  |||...|. ||. |.|
arsspilvhCsaGvGrtGtlvtlDsllsdfeilenltkesrkldvaaktrDlisiivnelrkqrismvqnldqfifiYeall
fn3 Fibronectin type III domain 5-92 7.5e-13 41.6 Pfam-A 2-85 (85) alignment 
Range on Protein: 5-92
Range on HMM: 2-85/85.0
PPSGVNHAEINSTTFNISWNPIPkdQSNGIITSYDLELSSRQARLrsRSLPESLNSTLTYIVLHDLENCTIYHLRVRARTGKGPGPYS
.|....  |..||....||.| .  . .| ||.|..|... .      .   .. .| |  .|..|.  | |..||.|..|.| ||.|
aPenlsvsevtstsltlsWsppk..dgggpitgYeveyrekggge..ewkeftvprtttsvtltgLkpgteYefrVqavngagegpeS
subfamily_eak_pd Subfamily eak 539-707 1.9e-12 41.2 In-house 28-196 (332) alignment 
Range on Protein: 539-707
Range on HMM: 28-196/332.0
RLNSVT--SREIPAEEKSVGEEPQNLHKNrFSDIIALNSCRVMLHKEHADeESDYINAVFLHAHRGRNAFIATQHPLLETVEDFWRMVTDYDIGTIVMLN
|.| |.   .  ..  .|...  .....|   .|.  .   | |     . .  ||||  .      . .| |  .  . |  ||.|| .    .||.| 
rinivadlddyqrllsisetarleavnrn.vvkivpydrylvrltssqln.rlGyinaslaefsevGrkyiltGiasedkvfafwqmvleqkspaivqll

NLHELD-QEYPKYWPDHG--PTKYGHIGVSVLSKQEQGDVICTKLKVtrkKVRRKTHEVRHLHHVSWPDKCIPE
.  ||. ... ||.||..    |.|.. |   .  ... .   .|..   ..  .||.| | .   | .  .| 
edvelkleksdkyfpdktreelkfGildverkefvkrniletrllel...skGnethrvlhykvfGwtettlpk
subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 264-412 2.6e-12 40.9 In-house 91-234 (244) alignment 
Range on Protein: 264-412
Range on HMM: 91-234/244.0
ARKPANKNKNRYANIVAYDHSRVVLERvnGDEDSDYINASFIhGYDGTPRSFIASQGPLPPAFEDFWRMVWEQNSQSIVMLTNLVElgktkCHKYWPDKT
| .| |  ||| .  . .| .|| | .  |     ||||||. |  |    .| .| ||  .  |||.|. |.  . .|.|  . |       .||||  
afnpnnswknregaglpfdfnrvplsk..gsmgntyinasfv.gclgrtaeyiltqhpladtsmdfwkmmlerhvnvlvvlgsvee.....edeywpdse

--ETYG-GVTVTLHQSEIFAEYEIRTFILSKAKQSGSRMVRQFHFTVWPDKG
  | |   .|||| . . | .     . .    .   . .  |  . ||  |
plewyeeditvtltdrdefknikasnleiesdmneshqaltmfqisnwpsdg
subfamily_CG42327_pd Subfamily CG42327 722-795 1.8e-11 38.3 In-house 241-315 (319) alignment 
Range on Protein: 722-795
Range on HMM: 241-315/319.0
SQQQCGNAPVLVQCSNGVGRSGTFCAISSVLERLKTE-QVIDVFQVIKRIRVNLPGAVESPTQYMFCYQIIQKYL
| ..  . |. | ||.||||.|.  |    ...|..  . .|. |..  .| .   || .  || | |.....| 
sgtresqGPlvvhcsdGvGrtGlviasdiairsleeskrsvdiPqlvssvrrdrasavltkeqyefiykvlseya
subfamily_Sponge-PTP2_pd Subfamily Sponge-PTP2 262-365 2.5e-11 36.7 In-house 19-89 (169) alignment 
Range on Protein: 262-365
Range on HMM: 19-89/169.0
EAARKPANKNKNRYANIVAYDHSRVVLERVNGDEDSDYINAsfihgydgtprsfiasqgplppafedfwRMVWEQNSQSIVMLTNLVElgktkCHKYWPD
  |   .|. ||| |  .|  | || |.||  |  ||||||                            ||.|| |.  ||.| .  .        .||.
fmaeltcnetknrpagplapshtrvklqrvmedlgsdyina............................rmiwetnasvivvlGdtdd.....knnfwpe

KTET
| . 
kedy
subfamily_Sponge-PTP-2_pd Subfamily Sponge-PTP-2 262-364 3.8e-11 36.2 In-house 20-89 (169) alignment 
Range on Protein: 262-364
Range on HMM: 20-89/169.0
EAARKPANKNKNRYANIVAYDHSRVVLERVNGDEDSDYINAsfihgydgtprsfiasqgplppafedfwRMVWEQNSQSIVMLTNLVElgktkCHKYWPD
  |   .|. ||| |  .|  | || |.||  |  ||||||                            ||.|| |.  ||.| .  .        .||.
fmaeltcnetknrpagplapshtrvklqrvmedlgsdyina............................rmiwetnasvivvlgdtdd.....knnfwpe

KTE
| .
ked
subfamily_Sponge-PTP-4_pd Subfamily Sponge-PTP-4 588-687 5.3e-11 36.9 In-house 12-108 (130) alignment 
Range on Protein: 588-687
Range on HMM: 12-108/130.0
ESDYINAVFLHAHRGRNAFIATQHPLLETVEDFWRMVTDYDIGTIVMLNNLHELDqeypKYWPDHGPTK-Y-GHIGVSVLSKQEQGDVICTKLKVTRkKV
. .|||| |.      . .. ||||| .|  |||.|. .  .  .|.|  . | |    .||||  | . |  .| |..  ..|   .  ..|.. . ..
gntyinasfvGllgrtaeylltqhpladtsmdfwkmmleryvnvlvvlgsveeed....eywpdsePlewyeediivtltdrdefknikasnleies.dl

RR
 .
ne
subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 557-634 7e-11 36.2 In-house 33-115 (347) alignment 
Range on Protein: 557-634
Range on HMM: 33-115/347.0
EEPQNLHKNRFSDIIALNSCRVMLHKEH-----ADEESDYINAVFLHAHRGRNAFIATQHPLLETVEDFWRMVTDYDIGTIVM
|  ..| |||  |    .. ||.|  |.     ||.   ||||  ..    .. .| ||.|| .|| |||.||.   .  .| 
ewekslsknrskdvklidatrvvlspeksknsraddvetyinashikfdnaskeyiltqyplpdtvrdfwkmvsvtkvtqvvt
subfamily_Sponge-PTP7_pd Subfamily Sponge-PTP7 733-790 1.1e-10 35.7 In-house 2-59 (69) alignment 
Range on Protein: 733-790
Range on HMM: 2-59/69.0
VQCSNGVGRSGTFCAISSVLERLKTEQVIDVFQVIKRIRVNLPGAVESPTQYMFCYQI
|.|| | ||.||| ||   . |.|.|...|.|  .. .|   |  |    .||| .. 
vhcssGtGrtGtfiaimvemarikseklvdifnnvqymrkcrpmmvmneneymfihda
subfamily_Sponge-PTP-7_pd Subfamily Sponge-PTP-7 732-790 1.5e-10 35.3 In-house 2-60 (69) alignment 
Range on Protein: 732-790
Range on HMM: 2-60/69.0
LVQCSNGVGRSGTFCAISSVLERLKTEQVIDVFQVIKRIRVNLPGAVESPTQYMFCYQI
.|.|| | ||.||| ||   . |.|.|...|.|  .. .|   |  |    .|.| .  
vvhcssgtgrtgtfiaimvemarikseklvdifnnvqymrkcrpmmvmneieyifihda
subfamily_Cele-PTP-5_pd Subfamily Cele-PTP-5 603-795 2.8e-10 33.3 In-house 114-309 (346) alignment 
Range on Protein: 603-795
Range on HMM: 114-309/346.0
RNAFIATQHPLLE---TVEDFWRMVTDYDIGTIVMLNNLHELDQEYPKYWPDHGpTKYGHIGVSVLSkQEQGDVICTKLKVTRKKVRR---KTHEVRHLH
 . .| .| | .|    ||||| |. . .|  . ..     | .     . |     | . |  ..  . . ||     . | . .      .  ..  |
ehklivaqlpqmenesfvedfwymiyqeqihlvylmvpddklkntttslfnden.ggyqytgkmfin.nrradvsgdpkeytievlpegnsdsvicqvhh

HVSWPDKCIPEVACSVLDLLDEAqTSQQQCGNAPVLVQCSNGVGRSGTFCAISSVLERLKTEQVIDVFQVIKRIRVNLPGAVESPTQYMFCYQIIQKYL
|  |     |  .  .. .. .   |..|  || | |    | ||. .|      ...|      ......| |. . ||.||| .||   | |.  |.
hapwkhlqqppktlpiikmihqf.lsekqvqnagvcvvslfgcgracsfigalyainqlnngiepniceimknikqqrpggvesfaqyasiyaivfdyi
subfamily_eak_pd Subfamily eak 435-510 3.7e-10 33.7 In-house 237-313 (332) alignment 
Range on Protein: 435-510
Range on HMM: 237-313/332.0
AGPvIVHCSAGVGRTGAYIVIDAMLE--QAKKSRTVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVLEALTCGNTEIQ
  | |. .. |  |.|...||| ...  ..||  .  . ....  .. | | | .. |.|||. .||. |   | ...
fap.iiqsarGsaraGvfvvidllirlidnkkknlysvedlilkvkskrihsvlvalqhsfiyeivldyllrrnnrlr
subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 269-342 6.2e-10 33.1 In-house 37-114 (347) alignment 
Range on Protein: 269-342
Range on HMM: 37-114/347.0
NKNKNRYANIVAYDHSRVVLER-----VNGDEDSDYINASFIHgYDGTPRSFIASQGPLPPAFEDFWRMVWEQNSQSIV
. .|||  .    | .||||        . |.   ||||| |. .| . . .| .| ||| .  |||.||   .   .|
slsknrskdvklidatrvvlspeksknsraddvetyinashik.fdnaskeyiltqyplpdtvrdfwkmvsvtkvtqvv
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 549-652 1.9e-09 31.3 In-house 36-156 (349) alignment 
Range on Protein: 549-652
Range on HMM: 36-156/349.0
PAEEKSVGEEPQNLHKNRFSDIIALNSCRVMLHKE--------HADEE------SDYINAVFLHAHRG--RNAFIATQHPLLETVEDFWRMVTDYDIGTI
....  . |  .   |||..||.  .  ||.|.|         ..  |       ||||| .|.  |    . .|||| ||  ||.||.....   .  .
eiddvilseGvelfaknrykdilPyehsrvklkkslksskvikastsesdsgklddyinanylkltrisvekkyiatqaPlPstvddfykvillngvklv

VMLNNLHELDQEY-PKYWPDH
. ||. .||. |   .|| . 
lsLnddkelslekcdiywqel
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 313-389 3.5e-09 30.5 In-house 236-311 (440) alignment 
Range on Protein: 313-389
Range on HMM: 236-311/440.0
RSFIASQGPLPPAFEDFWRMVWEQNSQSIVMLTNLVElgkTKCHKYWPDKTE--TYGGVTVTLHQSEIFAEYEIRTFIL
 .|||.| ||  .  ||||.| . .  .|.|| .| .     |  ||| .|   |.|  ||  . || .    .||. |
nafiatqmpldstvldfwrlvhdyristiimlnqlnd...ktcsiywpvntrsvtfgpftvghkgsenmnrvkvrtlel
subfamily_Cele-PTP-12_pd Subfamily Cele-PTP-12 268-352 1.5e-08 28.5 In-house 33-115 (332) alignment 
Range on Protein: 268-352
Range on HMM: 33-115/332.0
ANKNKNRYANIVAYDHSRVVLERVNGDedSDYINASFIHGYDGTpRSFIASQGPLPPAFED-FWRMVWEQNSQSIVMLTNLVELGK
 | . ||   . ..||||| |   .|    |. |||.. ||     ..| .| |.    |  ||||| |..   |... .. |  |
nnmdmnriphlycfdhsrvelapqdgk..ddfynaswvdgyskk.sayifaqapfndhteyvfwrmvserkpsmilvfgdidekqk
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 689-794 1.6e-08 28.7 In-house 214-343 (350) alignment 
Range on Protein: 689-794
Range on HMM: 214-343/350.0
THEVRHLHHVSWPDK---CIPEVACSVLD----LLDE--AQTSQQQCGNAPVLVQCSNGVGRSGTFCAISSVLERL-KTEQ-------------VID-VF
 ..| .|.   |.|      ||   ..|.    |.|.  |..  ..   .|.|| || |||| ||.... |.|. .   |.             . | ..
PyvvyqlqvknWkDlslllnPesilqalevkndliddlfaeshldnarsspilvhCsaGvGrtGtlvtlDsllsdfeilenltkesrkldvaaktrDlis

QVIKRIRVNLPGAVESPTQYMFCYQIIQKY
......|      | . .|..|.|. .. |
iivnelrkqrismvqnldqfifiYeallfy
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 433-500 1.7e-08 28.2 In-house 263-342 (349) alignment 
Range on Protein: 433-500
Range on HMM: 263-342/349.0
RDAGPVIVHCSAGVGRTGAYIVIDAMLE----QAKKSRTVDIRNY-------LI-ALRKDRPHMVQTKEQYSFIHSAVLE
 .  ...|||||| |||| .. .| .|.      ..|  .....         .  ||| |  |||   |. .|. |.|.
dqlstllvhcsaGcGrtGvlvtldlllsileplqnesnkiklqallkDlisiivnelrkqrismvqnlaqfiaiyealLk
subfamily_Cele-PTP-12_pd Subfamily Cele-PTP-12 349-495 2.6e-08 27.7 In-house 144-295 (332) alignment 
Range on Protein: 349-495
Range on HMM: 144-295/332.0
ELGKTKCHKYWPDKTETYGGVTVTLHQSEIFAEYEIRTFILSKAKQSGSRMVRQFHFTVWPDK-GVPQYATAVLAFRR--KVRALN--PRDAGPVIVHCS
||    |.|.||.|.      ..... |. ..|  ..|| |. ...   .    .||  | |   .|.|   . |  .   .|. .      ||... |.
elkakicrkfwpekrskkdfpalsiqasddhsethmktfnltvtekkqdhqtvlmhfyewadasklpeymldmrasiklqyirsskktgvcigpimlvca

AGVGRTGAYIVIDAMLEQAKKSRTVDIRNYLIALRKDRPHMVQTKEQYSFIH
.|| .   .  || .. .  . . | ... . |.. .|   ..|   ||   
tgvekcaisatidiivsriteehrvgfketmsaikmqrfgcfrtvgpystac
subfamily_Sponge-PTP-4_pd Subfamily Sponge-PTP-4 281-412 3.2e-08 27.9 In-house 5-125 (130) alignment 
Range on Protein: 281-412
Range on HMM: 5-125/130.0
YDHSRVVlervngdeDSDYINASFIhGYDGTPRSFIASQGPLPPAFEDFWRMVWEQNSQSIVMLTNLVElgktkCHKYWPDKT--ETY-GGVTVTLHQSE
.. ||.         . .||||||. |  |  . .. .| ||  .  |||.|. |.    .|.|  . |       .||||    | |   ..||| . .
fevsrlq........gntyinasfv.Gllgrtaeylltqhpladtsmdfwkmmleryvnvlvvlgsvee.....edeywpdsePlewyeediivtltdrd

IFAEYEIRTFILSKAKQSGSRMVRQFHFTVWPDKG
 | . .   .  ..  .   . .  |. . ||  |
efknikasnleiesdlneshqaltmfqisnwpsdg
subfamily_Sponge-PTP3_pd Subfamily Sponge-PTP3 553-610 6.7e-08 26.6 In-house 40-94 (95) alignment 
Range on Protein: 553-610
Range on HMM: 40-94/95.0
KSVGEEPQNLHKNRFSDIIALNSCRVMLHKEhadEESDYINAVFLHAHRGRNAFIATQ
 .||    |. |||| .|.  .. ||.|       .||||||.|.  .  .|..||.|
ytvgsseanipknrflnifpydatrvvlttk...rdsdyinacfvdgyarkncyiaaq
subfamily_PTPDC1_pd Subfamily PTPDC1 406-495 8.9e-08 26.8 In-house 88-169 (182) alignment 
Range on Protein: 406-495
Range on HMM: 88-169/182.0
TVWPDKGVPQYATAvLAFRrKVRALNPrDAGPVIVHCSAGVGRTGAyiVIDAMLEQAKKsrtVDIRNYLIALRKDRPHMVQTKEQYSFIH
  |.| ||.   .. |    || |    . | | ||| || ||||   .| ..|  ||.   ..  . .  .|. ||. .||.||  ...
fgwkDygvasleri.Ldiv.kvvafal.qegkvavhChaGlGrtGv..liacylvyakr...ltaekaiklvrskrpksiqtreqvelvk
subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 254-309 1.3e-07 25.5 In-house 24-78 (244) alignment 
Range on Protein: 254-309
Range on HMM: 24-78/244.0
DNGQQFPWEAARKPANKNKNRYANIVAYDHSRVVLERVnGDEDSDYINASFIHGYD
|. ..|    |   ||  |||| ||. .|..||.|      | ||||||..|.| .
dhtreflqtnavlsanatknryinilpfdetrvilsss.kkegsdyinanyiqgsq
0038934 (Phosphotyrosine protein) phosphatases II 404-495 4.7e-07 25.1 In-house 83-170 (194) alignment 
Range on Protein: 404-495
Range on HMM: 83-170/194.0
HFTVWPDKG-VPQYATAVLAFRRKVRALNPRDAGPVIVHCSAGVGRTGAYIVIdAMLEqakkSRTVDIRNYLIALRKDRPHMVQTKEQYSFIH
.   .||.| ||....    ..   . ||    | | ||| ||.||||  ..  ....    ..  . .  .  .|  ||..... .... ..
lklpfpddgtvPsleillrfldlvdeflnedpggvvaVHCkaGlgRtGtlvaa.YLiy....rlgmsaeeAialfrekRpgaipnqdyleall
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 717-757 7.3e-06 19.5 In-house 252-294 (349) alignment 
Range on Protein: 717-757
Range on HMM: 252-294/349.0
DE--AQTSQQQCGNAPVLVQCSNGVGRSGTFCAISSVLERLKT
|.  |.   ..   ...|| || | ||.|... . ..|. |. 
ddlfarlyldtdqlstllvhcsaGcGrtGvlvtldlllsilep