Gene NvecPTP-sf2-4 in Nematostella vectensis

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily NvecPTP-sf2
Protein sequence
ID Type Fasta BLAST phosphatome Note
NvecP047_AA protein Get Run
NvecP047_AA_115-392 phosphatase_domain Get Run
NvecP047_AA_404-624 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_PTPRD_pd Subfamily PTPRD 112-626 1e-247 818.3 In-house 2-514 (564) alignment 
Range on Protein: 112-626
Range on HMM: 2-514/564.0
SKPIPIALFPEYVAKMH--GGIRLETEYKKFNNGQQFPWGAARKPAnkNKNKNRYANIVAYDHSRVVLERVNGDEDLDYINASFIHGYDgTPRSFIASQG
|||||.| ..|.|||..  .....|.||||...||||.| ||.|||  ||.|||||||||||||||||..|.|||. ||||||||.||. .....||.||
skpipvaelkehvaklkansdlkfeeeykkieegqqftweaankpa..NkaKNRyanivaYdhsRVvLskvegdegsDYINAsfidgyr.krkayIAtqg

PLPPAFEGFWRMVWEQNSQSIVMLTNLVGLNKTKCHKYWPDK-TETYGGVTVTLHQSEVFAGYENCTFILSKEKRSGSRIVRQFHFTVWPDKGVPQYATA
||....| ||||||||||..|||||.|.  .|.|||||||.| |||||..||||...| .| || .||.|.|.|.| || ||||||| |||.|||..||.
PlaetiedFWRmvweqnsstiVmltkleEkgkvkchkYWPekgtetygeltVtleeeeeladyeirtfklkkkkssesreVrqFhFtsWPdhgvpesats

VLAFRRKVRALNPRDAGPVIVHCSVGVERTGAYIVIDAMLEQAKKSRTVDIRNYLIAIRKHRPHMVQTKEQYSFIHSAVLEALTCGNTEIQSEKYNQAMQ
.|...|||||||..||||..|||| ||.|||..||||||||..|...||||..|..|.||.|..||||.|||.|||.|.||||.|||||..||...|..|
lLdlirkvralnepdagPivVhCSaGVGRTGtfividamlerikeektvDiyqyvkalrkqRnamVqteeQYiFiheailealacgntevesenlkqhlq

KLASVNGKFPMTGYALEFQRLNsvTSREIPVEEKSVGEKPQNLHKNRFSDIIALNSCRVMLHKEHADEESDYINAVFLHAHRGRNAFIATQHPLLETVED
|||.|. .. |||..||||||.  |..||..||..|..||.|..|||||.|.||.||||.|....|.||||||||..|.|.|...||||||.|| .||||
kLaeveedtemtgleleFqrLa..takeieleefavatkpknkkknrfsnilalescrvvlsairakeesdyinasyleayrekrafiatqaplkntved

FWRMVTDYDIGTIVMLNNLHDQVAPESSEYWPDHGATKYGHIGISVLSKQKKGDVICVKPKVTRKKKTHEVRHLHHVSWTDKCIPKVSRSVLDLLDEVQT
|||||.......||||..|..... |||||..|..|||||.|.|.||.|..|.|....| ||..|.|...|..||.|...||.. .|..||||||..|..
fwrmvweeevkiivmltkleekleeesseyysdleatkyGeitikvlkkkeksdilfrkkkvevkekseavyllhtvqavdkklltvidsvldllkavrk

SQQQCGNVPVLVQCRYNK
..... .|.|  ..... 
vleravvvrvsegvtvtg
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 109-399 8.3e-130 427.4 In-house 3-298 (298) alignment 
Range on Protein: 109-399
Range on HMM: 3-298/298.0
DDLSKPIPIALFPEYVAKMH--GGIRLETEYKKFNNGQQ----FPWGAARKPAnkNKNKNRYANIVAYDHSRVVLERVNGDEDLDYINASFIHGYDGTPr
....... .|......|...  . .....|....|....    . . .||||.  ||.|||||.|.|.|.||||||....||. |||||||.|.|.|.. 
teieaedlkaalqklaavkkkkkltgyalefqrlnsvsseieeeekevarkpe..nkkkNRyadiialdssRvvLekedadeesdYiNAsflhaykgrn.

SFIASQGPLPPAFEGFWRMVWEQNSQSIVMLTNLVGLNKTKCHKYWPD-KTETYGGVTVTLHQSEVFAGYENCTFILSKEKRSGSRIVRQFHFTVWPDKG
.|||.|.||....|.|||||.|.....|||||||. |.|||.|||||| ..|||| .||.|...|.|| ........||.|....| |||.|||.|||||
afiatqaPltetvedFWrmvteedigtiVmltnleeldktkyhkywPdegketygeitvsllskeefadlivrklkvskkkeekerevrqlhftsWpdkg

VPQYATAVLAFRRKVRAlNPRDAG--PVIVHCSVGVERTGAYIVIDAMLEQAKKSRTVDIRNYLIAIRKHRPHMVQTKEQYSFIHSAVLEALTCGNTEIQ
||..||.||...||||| ....||  ||||.|| ||.|.|..|.||..||..||...||........||.||..|||.|||.||..||||||...|.||.
vpenatsvldllrkvra.sqqqagnkpvivqCsaGvgRsGtfiaidsvlervkkeqvvDvfqvvkvlRkkrpgavqteeqYvfiyeavlealdsfndeie
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 151-400 5.9e-118 387.6 In-house 4-245 (250) alignment 
Range on Protein: 151-400
Range on HMM: 4-245/250.0
ARKPAnkNKNKNRYANIVAYDHSRVVLERVNGDEDLDYINASFIHGYDGTpRSFIASQGPLPPAFEGFWRMVWEQNSQSIVMLTNLVGLNKTkCHKYWP-
|.||.  ||.|||||.|.|.|.||||||...||.. |||||||.||||.. ..|||.||||....|.|||||.|..|..|||||||.  .|| .|.||| 
akkpq..nkeknryadiialdssrvvLekekgdkesdyinasflhgyder.kafiatqgPlqatiedfWrmvleeksgtivmLtnLkesekt.yhqywPv

DKTETYGGVTVTLHQSEVFAGYENCTFILSKEKRSGSRIVRQFHFTVWPDKGVPQYATAVLAFRRKVRALNPR-DAGPVIVHCSVGVERTGAYIVIDAML
.|.|.||.|||.|...|.|| |.  ...|||.|....|||||.||.||||||||..|||||....||.| ... ...||||.|| || |.||.|.|||.|
ekaekyGdvtvsllskeefadytkrklklskakkaderivrqlhfvvWPdkgvPevatavLellkkvqasqqqagnaPvivqCsaGvgrsGafiaidavl

EQAKKSRTVDIRNYLIAIRKHRPHMVQTKEQYSFIHSAVLEALTCgnteiqS
|..||...||........||.|||.|...|||.|.....|.||..      .
erlkkekvvdvfkvikvlrkdrphavesleqyvfvyeiilkalds......v
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 117-429 2.2e-103 340.6 In-house 4-318 (318) alignment 
Range on Protein: 117-429
Range on HMM: 4-318/318.0
IALFPEYVAKM--HGGIRLETEYKKF-NNGQQFPWGAARKPANKnkNKNRYANIVAYDHSRVVLERVNGDEDLDYINASFIHGYDgTPRSFIASQGPLPP
.  . . |...  .| . |..||...  . ... .  . .|.||  .|||||||.||||.|| |. ..|.|. |||||..| ||    ...||.|.||| 
vedleshvrrlresGelllseeyerlsrseetvtslkslepvnk..aknryanilaydhtrvkLqmlegeegsDyinanyidGyr.rkkayiaaqaPlpe

AFEGFWRMVWEQNSQSIVMLTNLVGLNKTKCHKYWPDK-TETYGGVTVTLHQSEVFAGYENCTFILSKEKRSGSRIVRQFHFTVWPDKGVPQYATAVLAF
..| ||||||||||. |||||...   |.|.|.|||.| ...|| ..|.|...  .. |   .| ..... . ||.|||.|.| |||.|||. .. .|..
tieDfWrmvWeqnsavivmltqeeergkakvhryWPskgsrsygklvvelkeevelsdyvlrefkvtrteeeesrqvrqyhytsWpdegvpesgaslldl

RRKVRALN-PRDAGPVIVHCSVGVERTGAYIVIDAMLEQAKKSRTVDIRNYLIAIRKHRPHMVQTKEQYSFIHSAVLEALTCGNTEIQSEKYNQAMQKLA
 |.|.. . . .|||..|||| || ||| .|..|..||..|.  .||. ..   .|..|. ||||..|| ||. ..||||..|.||..... .. ...| 
vrqvskaqqksgagpivvhCsaGvGrtGvfiavdillerikaealvDvfqtvkqlreqrnlmvqtedqyefiydvllealasgdtevdasdlrsrirelr

SVNGKFPMTGYALEFQRL
 .. .  .|   .|||||
eqdpesgttemdaefqrl
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 394-622 1e-102 338.4 In-house 1-230 (298) alignment 
Range on Protein: 394-622
Range on HMM: 1-230/298.0
GNTEIQSEKYNQAMQKLASVNGKFPMTGYALEFQRLNSVTSrEIPVEEKSVGEKPQNLHKNRFSDIIALNSCRVMLHKEHADEESDYINAVFLHAHRGRN
|||||..|....|.||||.|. |. .|||||||||||||.| ||. |||.|..||.| .|||..|||||.|.||.|.||.||||||||||.||||..|||
gnteieaedlkaalqklaavkkkkkltgyalefqrlnsvss.eieeeekevarkpenkkkNRyadiialdssRvvLekedadeesdYiNAsflhaykgrn

AFIATQHPLLETVEDFWRMVTDYDIGTIVMLNNLHDQVAPESSEYWPDHGATKYGHIGISVLSKQKKGDVICVKPKVTRKK--KTHEVRHLHHVSWTDKC
||||||.|| |||||||||||..||||||||.||...   . ..||||.|...||.| .|.|||....|.|..| ||..||  |..|||.||..||.||.
afiatqaPltetvedFWrmvteedigtiVmltnleeldktkyhkywPdegketygeitvsllskeefadlivrklkvskkkeekerevrqlhftsWpdkg

IPKVSRSVLDLLDEVQTSQQQCGNVPVLVQC
.|....||||||..|..||||.||.||.|||
vpenatsvldllrkvrasqqqagnkpvivqC
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 115-427 1.5e-96 318.2 In-house 5-319 (319) alignment 
Range on Protein: 115-427
Range on HMM: 5-319/319.0
IPIALFPEYVAKMH--GGIRLETEYKKFNNGQQFPWGAARKPanKNKNKNRYANIVAYDHSRVVLERVNGDEDLDYINASFIHGYDGTpRSFIASQGPLP
|... . |.. ...  |   || |.|........ .  | |.  .||.|||| ||.|||..||||  ..| |. |||||||| ||.   . ||| |.|| 
ievqeLkerlkalastgetllekefkllkeavndtfdsaske..enkkknryqnilaydrtrvvlseldgvegsdyinasfidgyqer.ekfiatqaPle

PAFEGFWRMVWEQNSQSIVMLTNLVGLNKTKCHKYWPDKT-ETYGGVTVTLHQSEVFAGYENCTFILSKEKRSG-SRIVRQFHFTVWPDKGVPQYATAVL
 ..| |||||||..|  .||||.||   | |..||||... |.|| ..||| . |  ..|.   . | | .    .| | .|..| |||..||..||..|
ntiedfWrmvWeeessivvmltklveklkvklkkywpeenfeeyGrlivtleeeeeledyiirklklnkkssevetRevkhfqyteWpdhdvPekatsll

AFRRKVRALNPR-DAGPVIVHCSVGVERTGAYIVIDAMLEQAKKSRTVDIRNYLIAIRKHRPHMVQTKEQYSFIHSAVLEALTCGNTEIQSEKYNQAMQK
.. ...|    . ..||..|||| || |||..||.|||||. |.  ..|. ..   .|  |. |||..|||.||. |.|||...|.|||. .. .. ...
dllkrirksrektqsgPivvhCsaGvGRtGtfivldamlervkeegvlDvfstvsrlRtqRnimvqrpeqYkfiyealleaveagdteievqdlrdrlkq

LASVNGKFPMTGYALEFQ
||. . .  .|| . |||
laekvadtgetglerefq
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 157-390 4.8e-96 315.5 In-house 6-239 (239) alignment 
Range on Protein: 157-390
Range on HMM: 6-239/239.0
KNKNKNRYANIVAYDHSRVVLERVNGDEDLDYINASFIHGYDGTPRSFIASQGPLPPAFEGFWRMVWEQNSQSIVMLTNLVGLNKTKCHKYWPDKTETYG
 || ||||||||.|||||||||... |   ||||||... |||.|...||.|| . ..   ||||.|..    ||||| |.   | |||.|||| |  | 
vnkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdstskyc

GVTVTLHQSEVFAGYENCTFILSKEKRSGSRIVRQFHFTVWPDKGVPQYATAVLAFRRKVRALNPRDAGPVIVHCSVGVERTGAYIVIDAMLEQAKKSRT
 . |||...|||| |   ||..|.  ..  | | |.|||||||||||||||||| .|||.   .   | | ..||| || ||||..|||||| |||| .|
nlrvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcsagvgrtgaflvidamlrqakkqkt

VDIRNYLIAIRKHRPHMVQTKEQYSFIHSAVLEA
||| ||. |||. ||||||| ||| ||| |||||
vdifnyvkairedrphmvqtseqyvfihlavlea
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 156-389 1.5e-95 313.9 In-house 6-239 (239) alignment 
Range on Protein: 156-389
Range on HMM: 6-239/239.0
NKNKNKNRYANIVAYDHSRVVLERVNGDEDLDYINASFIHGYDGTPRSFIASQGPLPPAFEGFWRMVWEQNSQSIVMLTNLVGLNKTKCHKYWPDKTETY
  || ||||||||.|||||||||... |   ||||||... |||.|...||.|| . ..   ||||.|..    ||||| |.   | |||.|||| |  |
rvnkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdstsky

GGVTVTLHQSEVFAGYENCTFILSKEKRSGSRIVRQFHFTVWPDKGVPQYATAVLAFRRKVRALNPRDAGPVIVHCSVGVERTGAYIVIDAMLEQAKKSR
  . |||...|||| |   ||..|.  ..  | | |.|||||||||||||||||| .|||.   .   | | ..||| || ||||..|||||| |||| .
cnlrvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcsagvgrtgaflvidamlrqakkqk

TVDIRNYLIAIRKHRPHMVQTKEQYSFIHSAVLE
|||| ||. |||. ||||||| ||| ||| ||||
tvdifnyvkairedrphmvqtseqyvfihlavle
subfamily_PTPRG_pd Subfamily PTPRG 115-405 2.1e-95 315.1 In-house 1-301 (563) alignment 
Range on Protein: 115-405
Range on HMM: 1-301/563.0
IPIALFPEYVAKMHG--GIRLETEYK---KFNNGQQFPWGAARKPanKNKNKNRYANIVAYDHSRVVLERVNGD-EDLDYINASFIHGYDgTPRSFIASQ
.|.  | ..||..|    |... |..   .  . ....  ...||  .||.|||| ||||||.||| |. . |  ..||||||..|.||    . |||.|
vpvkefakhvaslhadgdigfseefealqsetiskdldaehsqkp..enkrKnRylnivaydrsRvklsplpgkkkklDYinAnyidGyq.kskafiatq

GPLPPAFEGFWRMVWEQNSQSIVMLTNLVGLNKTKCHKYWP-DKTETYGGVTVTLHQSEVFAGYENCTFILSK------EKRSGSRIVRQFHFTVWPDKG
|||.  |. ||||.||||.. |||.||||  .. ||. ||| |..|||| ..||| ..||.| |   |... .      ...   . |||.|.| |||.|
gplkdtfddFWrmiWeqnvaiivmitnlvergrrkcdvYWPkdesetygalqvtlieeevlalytvrtlviknlklkkkkqcdteklvrqyhytkWPdhg

VPQYATAVLAFRRKVRALNPRDAGPVIVHCSVGVERTGAYIVIDAMLEQAKKSRTVDIRNYLIAIRKHRPHMVQTKEQYSFIHSAVLEALTCGNTEIQSE
||.... || | .|  | |...|||..|||| || ||| |||.|..|.| ..  .|.. . |  || .|...|||.||| |.| |.|||.. ..||...|
vPehslpvLifvkkssaankaeaGPivvHcsaGvgrtGtyivldtllkqiqqenavnvfgflkhiraqRnflvqteEqYiflhdalleaiasketellae

KYNQ
. ..
qvee
0050432 (Phosphotyrosine protein) phosphatases II 103-395 2.1e-91 301.7 In-house 14-303 (308) alignment 
Range on Protein: 103-395
Range on HMM: 14-303/308.0
ICDNAVDDLSKPIPIALFPEYVAKMHGGIRLETEYKKFNNGQQfPWGAARKPANKNKNKNRYANIVAYDHSRVVLervngDEDLDYINASFIHGYD-GTP
 .|. .   |.....  . ... |...  .||.|...... .  ..        .||.|||| .|..||||||.|     ||. ||||||...||. . |
frdtsilvsslklsvldllkllekaldlglleeefeellsvkp.lleysvallpenkdkNrykdilpydhsRVkl.....degsdYInAsyvdgyssklp

RSFIASQGPLPPAFEGFWRMVWEQNSQSIVMLTNLVGLNKTKCHKYWPD----KTETYGGVTVTLHQSEVFAGYENCTFILSKEKRSGSRIVRQFHFTVW
| ||| |||||  .| |||||||||.. |||||.||  .. ||..|||.    ....||..||||   ||...|   |..|.. . . ||.|..||.| |
rkfIatqgPlpntvedFwrmvweqnvrvIvmLtklvengrekcaqYwplelgggsleygkftvtllseevlddytvrtleltnlgdgesrtvthfhytnW

PDKGVPQYATAVLAFRRKVRALNprDAGPVIVHCSVGVERTGAYIVIDAMLEQAKKSRTVDIRNYLIAIRKHRPHMVQTKEQYSFIHSAVLEALTCGN
|| |||......|.| ..||  .  . ||..|||| || |||..|..| .||| .| ..||. ...  .|..||.||||.||| |.. |.|| | .  
pdhgvPpspeilldflelvrksl..pggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtpeqylflyralleylklkl
0040438 (Phosphotyrosine protein) phosphatases II 129-409 2.8e-91 301.4 In-house 17-294 (317) alignment 
Range on Protein: 129-409
Range on HMM: 17-294/317.0
GgIRLETEYKKFNNGQQFPWGAARKPANKNknKNRYANIVAYDHSRVVLERVNGDEDLDYINASFIHGYDGTPRsFIASQGPLPPAFEGFWRMVWEQNSQ
   .|. |.... . .  ..  |..|.||.  |||| .|. ||||||.|  ..||.|.||||||...|.. ... ||| |||||  .| ||||||||...
f.talleefedllslkldtysvaelpenkd..knrypdilpydhsRVkLsplggdldsdYInAsyvdgpnlkrk.fIatqgPlpntvedFwrmvweqgvt

SIVMLTNLVGLNKTKCHKYWP-DKTETYGGVTVTLHQSEVFAGYENCTFILSKEKRSGSRIVRQFHFTVWPDKGVPQYATAVLAFRRKVRALNPRDAGPV
.|||||.|. |.. ||..||| ..| |||..|||| . |. ||..  |. ... . | ||.|..||.| ||| |||.. . .|.| ..||. .... |||
vivmLteleelgrekcaqYwplgetltygdftvtllseeelagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfleavrealedpggpv

IVHCSVGVERTGAYIVIDAMLEQAKKSRTVDIRNYLIAIRKHRPHMVQTKEQYSFIHSAVLEALTCGNTEIQSEKYNQAMQK
.|||| || |||..|... |||| .| ..||. . .  .|..||..||| ||| |.. |.|| |....| .   ..  ...|
lVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalleylkrkltlepaselklkllk
subfamily_PTPRB_pd Subfamily PTPRB 112-393 6.7e-90 296.1 In-house 4-287 (293) alignment 
Range on Protein: 112-393
Range on HMM: 4-287/293.0
SKPIPIALFPEYVAKMH--GGIRLETEYKKFNN-GQQFPWGAARKPAnkNKNKNRYANIVAYDHSRVVLERVNGDEDLDYINASFIHGYDgTPRSFIASQ
|||| .  | |.|.||.    .|.  ||..... |..    ||....  |..|||| ||..|||||| |. ...... |||||..|.||  .|| |||.|
skpiklekfeehvkkmkadsdlrfseeyeelkavgkdqavkaaelav..nraknrytnilpydhsrvkLaalkdesgsDYinanyipgyn.sprefiatq

GPLPPAFEGFWRMVWEQNSQSIVMLTNLVGLNKTKCHKYWPDK--TETYGGVTVTLHQSEVFAGYENCTFILSKEKRsgSRIVRQFHFTVWPDKGVPQYA
|||| ... |||||||..|. |||||.||   |.||..|||..  . .|| ..||| ..|.   .   .. ..|||.  .| |||.||| ||| |||. .
GPlpetvddfWrmvwekkssiivmltqlvekgkvkCeeYWPadeepvlyGdikvtlvaeeeledwvirelkiekeke..erkvrqyhftsWpdhgvPekt

TAVLAFRRKVRALN--PRDAGPVIVHCSVGVERTGAYIVIDAMLEQAKKSRTVDIRNYLIAIRKHRPHMVQTKEQYSFIHSAVLEALTC
...|.| |.||       ...|..|||| || |||..| .| .|.. ... .|||   ....|..| ..|||..|| |||..||. |. 
ktlldfvrtvreaiektaskrPivvhCsaGvGRtGtfialdrllqaieeedyvdifgivaelReeRnllvqtekqYifihqcvldllrk
subfamily_PTPRK_pd Subfamily PTPRK 130-408 9e-90 295.7 In-house 21-294 (314) alignment 
Range on Protein: 130-408
Range on HMM: 21-294/314.0
GIRLETEYKKFNNGqqfpWGAARKpaNKNKNKNRYANIVAYDHSRVVLERVNGDEDLDYINASFIHGYDgTPRSFIASQGPLPPAFEGFWRMVWEQNSQS
|  .  ||. . .|    | ||.|  ..|..|||. .|.|||.|||.|  ..|| . |||||..| .|   |. ||. ||||.   . |||.|...|. |
gygfkeeyeslfeg....wdaakk..denreknrsgdilaydrsrvflitidgdpssdyinaalidsyk.rpaafivtqgPlqetvkdfWrlvydencas

IVMLTNLVGLNKTKCHKYWPDKTETYGGVTVTLHQSEVFAGYENCTFILSK--EKRSGSRIVRQFHFTVWPDKGVPQYATAVLAFRRKVRALNPRDAGPV
|||||.||   . || ||||..||.|| . |.| ..|. | . . .| ..|   . .. |.||||.|. ||| .||..||..|.. |.| . .. .||..
ivmltelvevgrvkClkyWPedtevygdikvelvetellaelvvrifrveklargqeeirevrqfqflgWpdhdvPvsatgllklvrrvkksqeeeaGri

IVHCSVGVERTGAYIVIDAMLEQAKKSRTVDIRNYLIAIRKHRPHMVQTKEQYSFIHSAVLEALTCGNTEIQSEKYNQAMQ
.|||| |  |||..|.|| .|. ... ..||. |   ..|.... ||.|.||| ||. ..|||  ||.| |   ... .  
vvhCsaGaGrtGtfiaidivldmieregvvdvfnavktlrsrkvnmveteeqykfiydvileaclcgetaipvsefkalyl
0051299 (Phosphotyrosine protein) phosphatases II 127-391 4.6e-89 293.9 In-house 19-286 (288) alignment 
Range on Protein: 127-391
Range on HMM: 19-286/288.0
MHGGIRLETEYKKFNNGQQFpWGAARKPANKNKNKNRYANIVAYDHSRVVLERVNGDEDLDYINASFIHGYDGTPRsFIASQGPLPPAFEGFWRMVWEQN
..|  .|. |.... . .   .        .|..|||| .|..||||||.|  ..|.|. ||||||.|.||. . . ||| |||||  .| |||||||||
angltglleefeellsllpd.ltlsaallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyidgynlkrk.fIatqgPlpntvedFWrmvweqn

SQSIVMLTNLVGLNKTKCHKYWP-DKTETYGGVTVTLHQSEVFAGYENCTFILSKE----KRSGSRIVRQFHFTVWPDKGVPQYATAVLAFRRKVRALNP
.. |||||.|| |...||..||| ....||| .||||   ||...|   |.....     . . ||.|..||.| ||| |||......|.| |.||  ..
vrvIvmltklvelgrekcaqYwplggsltygditvtllseevlddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpdspellldflrlvrkala

RDAGPVIVHCSVGVERTGAYIVIDAMLEQAKKSRTVDIRNYLIAIRKHRPHMVQTKEQYSFIHSAVLEAL
 . |||.|||| || |||..|..| .||| .| ..||. ...  .|..||.|||| ||| |.. |.||.|
sgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtpeqyrfvyealleyl
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 113-411 2.8e-88 290.9 In-house 4-299 (315) alignment 
Range on Protein: 113-411
Range on HMM: 4-299/315.0
KPIPIALFPEYVAKMHGGIR--LETEYKKFNNGQQFPWGAARKPanKNKNKNRYANIVAYDHSRVVLERVNGDEDLDYINASFIHGYDgTPRSFIASQGP
.|||.  .  |||. .   .  .. .|.    || .|   |.|   .||.|||| ||.|||.||| |  .. |.. ||.||.|| ||.  .| .||.|||
qpipldqlityvaqkkastkngfkqdyesipggqlhpldvakki..enkqknryiniiaydksrvqlpllendphsdyvnanfidGyn.kkrryiaaqgp

LPPAFEGFWRMVWEQNSQSIVMLTNLVGLNKTKCHKYWPDKTETYGGVTVTLHQSEVFAGYENCTFilSKEKRSGSRIVRQFHFTVWPDKGVPQYATAVL
.. . . |||.|.|..   ||||||||  .| |. ||||||  .|| .|||. . ||.  |   |.  |   ..  | | |.|.| ||| |||.|.....
nvasvkdfwrlvfeedigkivmltnlvegekrkaekywpdkkviyGkitvtrkseevnteytvrtl..svvfgdnirevvqlhytswpdmgvpkytiplm

AFRRKVRALNPRDAGPVIVHCSVGVERTGAYIVIDAMLEQAKKSRTVDIRNYLIAIRKHRPHMVQTKEQYSFIHSAVLEALTCGNTEIQSEKYNQAMQKL
 . |.|.  .  ..|...|||| || |||..| .||.|.||.  . .|. |..  .|. | .|||. ||| ||..|.||.. ||.| |  . | |  . |
nlirtvkqhhtnsvgaivvhcsaGvGrtGtfitldavldqaeaenaidvynfitgvrqnrikmvqvaeqyqfiydalletfvcgdtsiaqdlylqrydsl

A
 
l
subfamily_PTPRA_pd Subfamily PTPRA 155-422 5.3e-88 290.1 In-house 55-326 (330) alignment 
Range on Protein: 155-422
Range on HMM: 55-326/330.0
ANKNKNKNRYANIVAYDHSRVVLERVNGDEDLDYINASFIHGYDGTpRSFIASQGPLPPAFEGFWRMVWEQNSQSIVMLTNLVGLNKTKCHKYWPDK-TE
 ..||.|||. ||. ||.|||.|  ..| |. ||||||||.||     .|||.|||.  . | ||||.|||.|..|||||.|   ...||..||||. . 
keenkeknrvvnilPydfsrvilsvkeGveesdyinasfidGykek.dkfiaaqGPkeetvedfwrmiweqksativmltelkerkeekcaqywPdeGlv

TYGGVTVTLHQSEVFAGYENCTFILS----KEKRSGSRIVRQFHFTVWPDKGVPQYATAVLAFRRKVRALNPRDAGPVIVHCSVGVERTGAYIVIDAMLE
||| ..|......|   |    |..     . ..  ||.||||||| ||| |||  .  .| . .||..||.. |||..|||| || |||..||.||.||
tyGnirvevedetvlvdytvrkflvqqlpdatrekksrlvrqfhftswPdvGvPfepiGmlkllkkvkklnqqsagpivvhcsaGvGrtGtfivldavle

QAKKSRTVDIRNYLIAIRKHRPHMVQTKEQYSFIHSAVLEALTCGNTEIQSEKYNQAMQKLASVNGKFPMTGY
. |  | ||. . .  .|. ||.||||.||| ||. ..||    |.||..    .. .||| .   ..  .| 
rvkaerkvdvfefvkrlrlqrpqmvqtdeqyefiykvlleyylygdteldvsslekhlqklynkitgtdkigl
0046845 (Phosphotyrosine protein) phosphatases II 133-396 3.2e-86 284.5 In-house 2-279 (284) alignment 
Range on Protein: 133-396
Range on HMM: 2-279/284.0
LETEYKKFNNGQQFPW-GAARKPANKNKNKNRYANIVAYDHSRVVLERVNGD-EDLDYINASFIHGYD----GTPRSFIASQGPLPPAFEGFWRMVWEQN
|| |... .. . ...       . .|..|||| .|..||||||.| ...|| || ||||||...|||     ... ||| |||||  .| |||||||||
leeefeellsltvklllslsvallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweqn

SQSIVMLTNLVGLNKTKCHKYWPDK--TETYGGVTVTLHQSEVFAGYENCTFILSKEK-RSGSRIVRQFHFTVWPDKGVPQYATAVLAFRRKVRALNP--
.. |||||.||  ...||..|||..  . |||..||||   ||. .|   |. |....  . ||.|..||.| ||| |||.... .|.| |.|| |..  
vrvIVmltelvengrekcaqYwplegevltygdftvtllseevkddytvrtleltnlgytgesrtvthfhytswpdhgvppspedlleflrlvrellenl

RDAGPVIVHCSVGVERTGAYIVIDAMLEQAKKSR---TVDIRNYLIAIRKHRPHMVQTKEQYSFIHSAVLEALTCGNT
 . ||..|||| || |||..|..| .||| .| .   .||. ...  .|..||.|||| ||| |.. |.||.| ...|
pgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyealleylklklt
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 157-389 6.3e-86 282.5 In-house 2-237 (237) alignment 
Range on Protein: 157-389
Range on HMM: 2-237/237.0
KNKNKNRYANIVAYDHSRVVLERVNGDedLDYINASFIHGYDGTPRSFIASQGPLPPAFEGFWRMVWEQNSQSIVMLTNLVGLNKTKCHKYWPD--KTET
.|| ||||.||||||||||||.   ..   |||||....|.||||...||.|||| .. . ||.|||...   ||||| |.  |. |||||||.  . ..
enkiknrygnivaydhsrvvlkgagsg..sdyinatylkgfdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywpstdqpaa

YGGVTVTLHQSEVFAGYENCTFILSKE-KRSGSRIVRQFHFTVWPDKGVPQYATAVLAFRRKVRALNPR--DAGPVIVHCSVGVERTGAYIVIDAMLEQA
|| .||.|.. | |. |   ...|||. .  . |.. |..||.|||.||||...|.| ||...   .|   ..|| |.||| || ||| ..|||||| ||
ygvltvslkkkeefsdytvrslllskrltlkevrlihqyqftswpdrgvpqqtaallrfrkniinrsphvsesgpwiihcsagvgrtgiflvidamlrqa

KKSRTVDIRNYLIAIRKHRPHMVQTKEQYSFIHSAVLE
|. . ||| ||. .| . ||...|||.|| ||| ..||
kekkvvdiynyvysieedrpyiiqtkdqyvfihqtile
0036941 (Phosphotyrosine protein) phosphatases II 147-402 9.9e-86 283.0 In-house 28-288 (297) alignment 
Range on Protein: 147-402
Range on HMM: 28-288/297.0
PWGAARKPANKNKNKNRYANIVAYDHSRVVLervnGDEDLDYINASFIHGYDGTPRsFIASQGPLPPAFEGFWRMVWEQNSQSIVMLTNLVGLNKTKCHK
..        .|..|||| .|..|||.||.|    .||. ||||||.. ||| . . ||| |||||  .| |||||||||...|||||.|| |.. ||..
lgslsvallpenleknRykdilpydhtRVkl....ddegsdYinAsyvdgydlkrk.fIatqgPlpntvedFWrmvweqnvtvIvmltelvelgrekcaq

YWP---DKTETYGGVTVTLHQSEV--FAGYENCTFILSKEKRSGSRIVRQFHFTVWPDKGVPQYATAVLAFRRKVRALNPR--DAGPVIVHCSVGVERTG
|||   ... |||..||||   ||  ...|   |. ... . . ||.|..||.| ||| |||.... .|.| ..||  ..   . |||.|||| || |.|
ywpleegesltygdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfielvrkvlkllpsggpvlVHCsaGvgRsg

AYIVIDAMLEQAK---KSRTVDIRNYLIAIRKHRPHMVQTKEQYSFIHSAVLEALTCGNTEIQSEK
..|..| ||.| .   | ..||| ...  .|..||..||| ||| |.. |.|| | ...| ..  |
tfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallellkkkltkepllk
0039614 (Phosphotyrosine protein) phosphatases II 107-395 1.6e-84 279.2 In-house 8-293 (297) alignment 
Range on Protein: 107-395
Range on HMM: 8-293/297.0
AVDDLSKPIPIALFPEYVAKMHGGIRLETEYKKFNNGQQfPWGAARKPanKNKNKNRYANIVAYDHSRVVLERVNG-DEDLDYINASFIHGYDGTPRSFI
...  ..|. .  .   . |. .  .|..|...  . .  ..  |..|  .||.|||| .|..||||||.|  ..| |.|.||||||.. ||| ..| ||
llesipiplsvldlllllekansktllllefeellslkp.dysiallp..enkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfI

ASQGPLPPAFEGFWRMVWEQNSQSIVMLTNLVGLNKtKCHKYWPDKTETYGGVTVTLHQSEVFAGYENCTFILSKekRSGSRIVRQFHFTVWPDKGVPQY
|.|||||  .| ||||||||....|||||.|| |.. ||..|||....|||..|||| . |. .||   |. ...   . ||.|..|..| ||| |||..
atqgPlpetvedFwrmvweqgvtvivmLtklvelgr.kcaqywpeeggtygdftvtllkvehldgytvrtlevtn..ngesrtvthfqytgwpdhgvpps

ATAVLAFRRKVRALNPR--DAGPVIVHCSVGVERTGAYIVIDAMLEQAKKSRTVDIRNYLIAIRKHRPHMVQTKEQYSFIHSAVLEALTCGN
.. .| | ..||  . .  . |||.|||| || |||..|... |||| .| ..||. . .  .|..||..||| .|| |.. |.|| | ...
lellleflelvrealaelpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydallellkrkl
0043336 (Phosphotyrosine protein) phosphatases II 128-389 3.3e-84 277.9 In-house 17-275 (278) alignment 
Range on Protein: 128-389
Range on HMM: 17-275/278.0
HGGIRLETEYKKFNNGQQFPWGAARKPANKNknKNRYANIVAYDHSRVVLERVNGDEDLDYINASFIHGYDGTPRsFIASQGPLPPAFEGFWRMVWEQNS
 .  .|. |...... . ...  |..|.||.  |||| .|..||||||.|. ..||.|.||||||.. ||. ... |||.|||||  .| |||||||...
nlktllllefeellsfkldtysiallpenkd..knrykdilpydhsrvklsllggdldsdYinAsyvdgynvprk.fiatqgPlpetvedFwrmvwelgv

QSIVMLTNLVGLNKTKCHKYWPDKTETYGGVTVTLHQSEVFAGYENCTFILSKEKRSGSRIVRQFHFTVWPDKGVPQYATAVLAFRRKVRALNPRDAGPV
..|||||.|| |...||..|||....|||..||||   |....|   |. ... . . ||.|...|.. ||| |||   . .| | ..||  .. . |||
ttivmLtelvelgrvkcaqYwpggsltygdftvtllkeehlddytvrtlevtnlgdgesrtvthyhylgwpdhgvpeslsllldflkavrealedsngpv

IVHCSVGVERTGAYIVIDAMLEQAKKSRTVDIRNYLIAIRKHRPHMVQTKEQYSFIHSAVLE
.|||| || |||..|... .|||..| ..||. . .  .|..||..||| .|| |.. |.||
lVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflyealle
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 133-392 6.7e-84 276.3 In-house 17-277 (281) alignment 
Range on Protein: 133-392
Range on HMM: 17-277/281.0
LETEYKKFNN-GQQFPWGAARKPAnkNKNKNRYANIVAYDHSRVVLERVNGDEDLDYINASFIHGYDGtPRSFIASQGPLPPAFEGFWRMVWEQNSQSIV
. .||.|... |.. .  |.....  |..|||| ||||||..||.... . ... |||||.|. ||.| .. .||.|||.| ... ||.|||||. . ||
fieeyeklaaigvdntataskade..nvlknrYsnivaYDatrvkvtpneenkntDYinanfvpgykg.ekeyiatqgPvPaslvafWqmvweqkvsaiv

MLTNLVGLNKTKCHKYWPDKT--ETYGGVTVTLHQSEVFAGYENCTFILsKEKRSGSRIVRQFHFTVWPDKGVPQYATAVLAFRRKV-RALNPRDAGPVI
|.|. .  .| |||.||||..   .|| |||. ...|  | | . .| | ... . .| |.|...| |||.|||. ....| ||..| .. ...   |..
mvtreieagklkChrYWPddnselkygdvtvkstaeeekatyierkfkl.eresgetreveqlaytaWPdhGvPattkellefrkevlkltekktkaplv

VHCSVGVERTGAYIVIDAMLEQAK-KSRTVDIRNYLIAIRKHRPHMVQTKEQYSFIHSAVLEALT
.||| || |||.|| .| ...... . ...|... .  .||.|  ||||  ||.|.. |||.|| 
ihCsaGvGrtGtyialDrlvkaveaeleeldvkavvaelrkernlmvqtvvqyefvykavldald
0047943 (Phosphotyrosine protein) phosphatases II 126-391 2.7e-83 274.9 In-house 7-272 (273) alignment 
Range on Protein: 126-391
Range on HMM: 7-272/273.0
KMHGGIRLETEYKKFNNGQQfPWGAARKPANKNKNKNRYANIVAYDHSRVVLervnGDEDLDYINASFIHGYDGTPRsFIASQGPLPPAFEGFWRMVWEQ
|. |  .|. |.... . .  ..        .||.|||| .|..||||||.|    ||.. ||||||.. ||. ... ||| |||||  .| ||||||||
kllgltllleefelllslkp.lltysvallpenkdknrykdilpydhsrvkl....gdggsdyinAsyvdgynlkrk.fiatqgPlpntvedfwrmvweq

NSQSIVMLTNLVGLNKTKCHKYWPDK----TETYGGVTVTLHQSEVFAGYENCTFILSKEKRSGSRIVRQFHFTVWPDKGVPQYATAVLAFRRKVRALNP
|.. |||||.|| |.. ||..|||..    ..||| .||||   |....|   |..|.. . . ||.|..||.| ||| |||.. . .| | ..||  . 
nvrviVmLtelvelgrekcaqYwpleggelsltygkftvtllseetkddytvrtleltnlgtgesrtvthfhytgwpdhgvppslesllefielvrkale

R--DAGPVIVHCSVGVERTGAYIVIDAMLEQAKKSRTVDIRNYLIAIRKHRPHMVQTKEQYSFIHSAVLEAL
   . |||.|||| || |||..|..| .|.| .| ..||. ...  .|..||.|||| ||| |.. |.|| |
alpsngpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrflyealleyl
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 114-411 3.3e-83 274.3 In-house 3-303 (305) alignment 
Range on Protein: 114-411
Range on HMM: 3-303/305.0
PIPIALFPEYV--AKMHGGIRLETEYKKFNNGqQFPWGAARKpaNKNKNKNRYANIVAYDHSRVVLERVNGDEDLDYINASFIHGYDGTpRSFIASQGPL
.| .. . .|.  |...    ||..||.. .  . .    .|  ..||.|||...|. .|..|. |   . ..| ||||||...||..   ..|..||||
iialddlaayikearvysdkgleaqykslyee.eesidvgkk..eankaknrlkeitlldddriiltekeslddsdyinasyvdgykrk.kkyivaqgPl

PPAFEGFWRMVWEQNSQSIVMLTNLVGLNKTKCHKYWPDKTET---YGGVTVTLHQSEVFAGYENCTFILSK-EKRSGSRIVRQFHFTVWPDKGVPQYAT
.   . |||...|   ..|||||.||  .| ||..|||...     .| ..|.|.... ...| .  . .|. .. . || | |...| |||.||||.||
kntvadfWrliveekvstivmltklveggkdkCrqYWpesktekkefgefsvelksektasdyieRklkisiededkesrtvlqyqltdWPdhGvpqfat

AVLAFRRKVRALNPRDAG-PVIVHCSVGVERTGAYIVIDAMLEQAKKSRTVDIRNYLIAIRKHRPHMVQTKEQYSFIHSAVLEALTCGNTEIQSEKYNQA
..| . ..|.    .| | |..|||| || |||..|..| .||..||  .||. ..| ..|..|. ||||..|| |.| |. | .|||.|.|  . .. .
sllslikrvqkdqkkdkgvpllVhCsagvgRtGvfiavdialerlkkEevvdvfevlkqlRskrmkmvqtldqYvflhdaldelitcgdtsiigsnlrar

MQKLA
..|| 
vnklk
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 442-622 8.5e-82 269.1 In-house 1-182 (250) alignment 
Range on Protein: 442-622
Range on HMM: 1-182/250.0
KSVGEKPQNLHKNRFSDIIALNSCRVMLHKEHADEESDYINAVFLHAHRGRNAFIATQHPLLETVEDFWRMVTDYDIGTIVMLNNLHDQVAPeSSEYWPD
|||..||||..|||..|||||.|.||.|.||..|.|||||||.|||....|.||||||.|| .|.|||||||.....||||||.||...     ..||| 
ksvakkpqnkeknryadiialdssrvvLekekgdkesdyinasflhgyderkafiatqgPlqatiedfWrmvleeksgtivmLtnLkesekt.yhqywPv

HGATKYGHIGISVLSKQKKGDVICVKPKVTRKKKTHE--VRHLHHVSWTDKCIPKVSRSVLDLLDEVQTSQQQCGNVPVLVQC
 .|.|||.. .|.|||....|..  | |....||..|  ||.||.|.| ||..|.| ..||.||..||.||||.|| ||.|||
ekaekyGdvtvsllskeefadytkrklklskakkaderivrqlhfvvWPdkgvPevatavLellkkvqasqqqagnaPvivqC
0045450 (Phosphotyrosine protein) phosphatases II 128-391 1.1e-80 266.9 In-house 24-304 (307) alignment 
Range on Protein: 128-391
Range on HMM: 24-304/307.0
HGGIRLETEYKKFNNGQQF-PWGAARKPANKNKNKNRYANIVAYDHSRVVLERVNGD-EDLDYINASFI--------HGYDGtPRSFIASQGPLPPAFEG
 .  .|. |..|... . | ..        .||.|||| .|..|||.||.|  ..|. || ||||||..        .|||  .| ||| |||||  .| 
dfltgllkefekllsvtvfllgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydl.krkfIatqgPlpetved

FWRMVWEQNSQSIVMLTNLVGLNKTKCHKYWPDK--TETYGGVTVTLHQSEVFAGYENCTFILSKE-KRSGSRIVRQFHFTVWPDKGVPQYATAVLAFRR
||||.|||... |||||.|| |.. ||..||||.  . ||| .||||   |. .||   |. ..   . . ||.|..||.| ||| |||..   .|.| .
FwrmlweqgvtvivmltelvelgrekcaqywPdegeeltygnftvtllseehldgytvrtlevtdldgtgesrtvthfhytgwpdhgvppsfeelldfie

KVRALNPR--DAGPVIVHCSVGVERTGAYIVIDAMLEQAKKSRT---VDIRNYLIAIRKHRPHMVQTKEQYSFIHSAVLEAL
.||. . .  . |||.|||| || |||..|... ||.| .|  |   ||... .  .|..||..||. ||| |.. |.|| |
evrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyeallell
subfamily_Ptp69D_pd Subfamily Ptp69D 132-410 3.4e-80 264.4 In-house 23-305 (307) alignment 
Range on Protein: 132-410
Range on HMM: 23-305/307.0
RLETEYKKFNNGqQFPWGAARKPANKNKNKNRYANIVAYDHSRVVLERVNGDEDLDYINASFIHGYDGTpRSFIASQGPLPPAFEGFWRMVWEQNSQSIV
 |. ||.| ..  ...  .     . |. |||| .|.|.|. ||.|...||.|| ||||||||.||. . ..|||.|.|.    . ||||..||... ||
glakeyekLear.eidkstkvsekkenalknRyedikafDktRvkLkkingkedsdYinasfikgykek.kkfiaaqdPveatigDfWRmiaeqevtliv

MLTNLVGLNKTKCHKYWP-DKTETYGGVTVTLHQSEVFAGYENCTFILSKEKRSG-----SRIVRQFHFTVWPDKGVPQYATAVLAFRRKVRALNPRDAG
||.||   |. ||.|||| ...  || . |.| ..|    | . .. .|| | ..     || | |.|.| |.|  ||. |...| . ..|| |.  . .
mlsnlteknrkkcakYWpiedevqygdilvklvseekhsdyiiReldvskkkeesgevedsrkvvqyhytgWkDskvPevargllklieqvrelyklnrs

PVIVHCSVGVERTGAYIVIDAMLEQAKKSRTVDIRNYLIAIRKHRPHMVQTKEQYSFIHSAVLEALTCGNTEIQSEKYNQAMQKL
|..|||| ||.|.| .. .| .|.| |.  .||| .    .|..|. .||  |||.|.. |.|.  . |.|... .....|...|
PivvhCsaGvgrsgifvaldsllqqlkaedkvdifetvkdLrsqRnllvqsleqYvflyralldyssygdtdedvddledaierl
DSPc_SM00195 134-391 6.6e-80 263.6 In-house 3-262 (263) alignment 
Range on Protein: 134-391
Range on HMM: 3-262/263.0
ETEYKKFNNGQQFPwGAARKPANKNKNKNRYANIVAYDHSRVVLERVNGDEDLDYINASFIHGYdGTPRSFIASQGPLPPAFEGFWRMVWEQNSQSIVML
..|..| .. ..       .  .|||.|||| ||. |||.|| |.. ...|. |||||..| |.   ....|| |||||  .| |||||||.... ||||
keefekleestspk.etteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikga.nkkkkyIatQgPlpstvedFWrmvweekvkiivml

TNLVGLNKTKCHKYWPDK---TETYGGVTVTLHQSEVFA-GYENCTFILSKEKRSGSRIVRQFHFTVWPDKGVPQYATAVLAFRRKVRALNPRDAGPVIV
|. .  .|.||..|||..   .||.| ..|.| . |     ..  |. |.||... .| |.|.... |||.|||. .. ||.. |.|.  . .  ||..|
teeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkkskstssgpivV

HCSVGVERTGAYIVIDAMLEQAKKSRTVDIRNYLIAIRKHRPHMVQTKEQYSFIHSAVLEAL
||| ||.|||....|| .|.. ..  .||| . . ..||.||.||||.|||.||. |.||..
hCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi
PTPc_SM00194 134-391 6.6e-80 263.6 In-house 3-262 (263) alignment 
Range on Protein: 134-391
Range on HMM: 3-262/263.0
ETEYKKFNNGQQFPwGAARKPANKNKNKNRYANIVAYDHSRVVLERVNGDEDLDYINASFIHGYdGTPRSFIASQGPLPPAFEGFWRMVWEQNSQSIVML
..|..| .. ..       .  .|||.|||| ||. |||.|| |.. ...|. |||||..| |.   ....|| |||||  .| |||||||.... ||||
keefekleestspk.etteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikga.nkkkkyIatQgPlpstvedFWrmvweekvkiivml

TNLVGLNKTKCHKYWPDK---TETYGGVTVTLHQSEVFA-GYENCTFILSKEKRSGSRIVRQFHFTVWPDKGVPQYATAVLAFRRKVRALNPRDAGPVIV
|. .  .|.||..|||..   .||.| ..|.| . |     ..  |. |.||... .| |.|.... |||.|||. .. ||.. |.|.  . .  ||..|
teeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkkskstssgpivV

HCSVGVERTGAYIVIDAMLEQAKKSRTVDIRNYLIAIRKHRPHMVQTKEQYSFIHSAVLEAL
||| ||.|||....|| .|.. ..  .||| . . ..||.||.||||.|||.||. |.||..
hCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 133-390 6.9e-80 263.2 In-house 23-278 (288) alignment 
Range on Protein: 133-390
Range on HMM: 23-278/288.0
LETEYKKFNN-GQQFPWGAARKPanKNKNKNRYANIVAYDHSRVVLERVNGDEDLDYINASFIHGYDGTpRSFIASQGPLPPAFEGFWRMVWEQNSQSIV
.. ||..  . ...    |.|..  .|..|||| ||..||. || |. ..  .. ||||||.|.|.... . .||.||||. . . ||..|.|.... ||
fseeynsLaalektksvtagrla..vnakknRyrnilpyDekrvklkkleeeagaDYinasyidgekkk.kkyiatqgPladtvndfWelvyenktstiv

MLTNLVGLNKTKCHKYWPDKTE--TYGGVTVTLHQSEVFAGYENCTFILSkeKRSGSRIVRQFHFTVWPDKGVPQYATAVLAFRRKVRALNPRDAGPVIV
|||.||  .||||..||||. .   || ||||| .|.    . . ...|   |. . . . |.....|||.|||. .. .|...|.|   |. |.||.||
mltelveggktkCeeYWPdadkpknyGsvtvtlveskeledfvlrkllle..kkkteleitqyqylaWpdhgvPeskapllellrqvkvanqadtgpiiv

HCSVGVERTGAYIVIDAMLEQAKKSRTVDIRNYLIAIRKHRPHMVQTKEQYSFIHSAVLEA
||| || ||| .|..||.... ... ..|. . .  .||.|. .|||..|| ||....|. 
hCsaGvGrtgtFialdalidaveeedyiDvagtvaklRkqRallvqtlkqYefiyevllsl
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 114-434 5.5e-78 257.3 In-house 1-319 (515) alignment 
Range on Protein: 114-434
Range on HMM: 1-319/515.0
PIPIALFPEYVAKMHGGIRLETEYKKFNNGQQFPWGAARKPAnkNKNKNRYANIVAYDHSRVVLERVNGDEDLDYINASFIHGYDGtPRSFIASQGPLPP
|.|.| || .|.|      .  |.. .   . .|   |..    | .|||| ||. || .|| || .| . . ||.|||.|...|   ...||||||.. 
plplaqfPafvnknrhttlfseefhdlpgpniypqtvaqeei..nfkknryknilPydsvrvklevindnPhsdyfnasyipsfdn.dkayiasqgPnka

AFEGFWRMVWEQNSQSIVMLTNLVGLNKTKCHKYWPD---KTETYGGVTVTLHQSEVFAGYENCTFILSKEKRsgSRIVRQFHFTVWPDKGVPQYATAVL
. . |||.|...|   |.|.|.|   .| || |||||   ..  .| . | |   |  .|    .. . |..   || | ||||| |||||||. ....|
svddfWrlvlqenvttiamvtklkegdkikcgkyWPdkpgdsvkfGsikvelvsleactggikrkltvlkgdd..srtvtqfhfteWPdkGvpkhtssll

AFRRKVRALNPRDAGPVIVHCSVGVERTGAYIVIDAMLEQAKKSRTVDIRNYLIAIRKHRPHMVQTKEQYSFIHSAVLEALTCGNTEIQSEKYNQAMQKL
 . ..|.| . . . |.|.||| || ||| .| || .. .||..|.||. |..  ||..||..|||.|||.||. |||| |   || |   .. . .| |
klikevkadhgqythpliihcsaGvGrtGvvisidsvvahakttrmvdvfnfvtnirqkrpylvqtqeqyafiygavledllwrntlipvihftdhlqdl

ASVNGKFPMTGYALEFQRLNSVTS
 |       .  . ||| |.|.. 
hssgdgrgrskmtkefqtlkslcp
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 113-415 2.5e-77 254.8 In-house 1-301 (315) alignment 
Range on Protein: 113-415
Range on HMM: 1-301/315.0
KPIPIALFPEYVAKMHGGIRLETEYKKFNNGQQFPWGAARKPANknKNKNRYANIVAYDHSRVVLERVNGDEDLDYINASFIHGYDGtPRSFIASQGPLP
.|||.| || .| | .    .  |.. . . . ..  .||.. |   .|||| ||. .|..||.|| .. . | ||||||.|...|   ...|||||||.
qpipvaqfpafvnknrhtalfseefhdlpdPdiyrqrvaretin..fkknryknilPldsarvkleviddsPdsdyinasyiksvdd.dkayiasqgPlk

PAFEGFWRMVWEQNSQSIVMLTNLVGLNKTKCHKYWPD---KTETYGGVTVTLHQSEVFAGYENCTFILSKEKrsGSRIVRQFHFTVWPDKGVPQYATAV
 . . |||||....  .|||.|..   .| || .||||   ..  .| . |.| . |  ..  .  ... | .   || | ||.|| ||||||.. ....
asvddfwrmvlqekvttivmvtkkqegdkikcrqywPdrkadsvefGsikvellsleadtdgvarklvtrkse..esrtvtqfqftewPdkGvdkqtssl

LAFRRKVRALNPRDAGPVIVHCSVGVERTGAYIVIDAMLEQAKKSRTVDIRNYLIAIRKHRPHMVQTKEQYSFIHSAVLEALTCGNTEIQSEKYNQAMQK
| . ..|.| | ..  ...|||| || |||  | || ...|.|..|.||. |..  .|..||..|||.|.|.||. |||| |   || |   .. . .| 
lklikevkadngkkefsllvhcsaGvGrtGvvisidevvaqikrtrsvdvfnfvknlrakrpylvqteeeyafiydavledllwrntlilvihftdhlqd

LASVNG
| .  .
lhtsvd
Y_phosphatase Protein-tyrosine phosphatase 158-389 6.2e-77 253.5 Pfam-A 1-235 (235) alignment 
Range on Protein: 158-389
Range on HMM: 1-235/235.0
NKNKNRYANIVAYDHSRVVLERVNGDEDldYINASFIHGYDgTPRSFIASQGPLPPAFEGFWRMVWEQNSQSIVMLTNLVGLNKTKCHKYWP---DKTET
||.|||| .|..||..|| |.  .|..|  ||||....||. ....|||.||||.  .| ||||||......|||||.|.  ...||..|||   ....|
nkkknRykdilpydktrvklkgsegpsd..YInAnyvkgyk.ekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeeslt

YGGVTVTLH-QSE-VFAGYENCTFILSKEKRS-GSRIVRQFHFTVWPDKGVPQYATAVLAFRRKVRALNPRDAGPVIVHCSVGVERTGAYIVIDAMLEQA
|| ..|.|  ...   ..|   .. |.|.|..  .|.|.|.|.| |||.|||. ....| . |||.  .  . |||.|||| ||.||| ....|..|||.
ygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleql

KKSRTVDIRNYLIAIRKHRPHMVQTKEQYSFIHSAVLE
.. ..||. ...  .||.||.|||. ||| |.. |.||
eaeeevdvlqivkelRkqRpgmvqsleqYiflykaile
Y_phosphatase Protein-tyrosine phosphatase 158-389 6.2e-77 253.5 In-house 1-235 (235) alignment 
Range on Protein: 158-389
Range on HMM: 1-235/235.0
NKNKNRYANIVAYDHSRVVLERVNGDEDldYINASFIHGYDgTPRSFIASQGPLPPAFEGFWRMVWEQNSQSIVMLTNLVGLNKTKCHKYWP---DKTET
||.|||| .|..||..|| |.  .|..|  ||||....||. ....|||.||||.  .| ||||||......|||||.|.  ...||..|||   ....|
nkkknRykdilpydktrvklkgsegpsd..YInAnyvkgyk.ekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeeslt

YGGVTVTLH-QSE-VFAGYENCTFILSKEKRS-GSRIVRQFHFTVWPDKGVPQYATAVLAFRRKVRALNPRDAGPVIVHCSVGVERTGAYIVIDAMLEQA
|| ..|.|  ...   ..|   .. |.|.|..  .|.|.|.|.| |||.|||. ....| . |||.  .  . |||.|||| ||.||| ....|..|||.
ygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleql

KKSRTVDIRNYLIAIRKHRPHMVQTKEQYSFIHSAVLE
.. ..||. ...  .||.||.|||. ||| |.. |.||
eaeeevdvlqivkelRkqRpgmvqsleqYiflykaile
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 133-410 2.6e-76 252.0 In-house 36-310 (319) alignment 
Range on Protein: 133-410
Range on HMM: 36-310/319.0
LETEYKKFNNGQqfPWGAARKPA--NKNKNKNRYANIVAYDHSRVVLERVNGDEDLDYINASFIHGYDgTPRSFIASQGPLPPAFEGFWRMVWEQNSQSI
|| |...  .    . .| .. |  ..||.|||. ||.|.|...| |||..| |  |||||||. ||   .  .||.||||. . . ||||.||.|. .|
levefrracklg..vnladqtfanldqnkdknriinilafdknvvklerliGeefsdyinasfvtGyq.rkdkyiaaqGPldntladfWrmiweyncsti

VMLTnlvglnKTKCHKYWPDKT-ETYGGVTVTLHQSEVFAGYENCTFILSK-EKRSGSRIVRQFHFTVWPDKGVPQYATAVLAFRRKVRALNPRDAG--P
|.||      | || .||| |. ....   | ..  |  | |    . ||.  |  . | ..||||  |||.|||.|.. .. . .||| |. .  .  .
vllt......kdkcsqywplkivikeerfkvkvdsveetaeyvvrdielsedgkekdirkitqfhflGwpdvGvpdypsdlmrlvkkvrhltskenhran

VIVHCSVGVERTGAYIVIDAMLEQAKKSRTVDIRNYLIAIRKHRPHMVQTKEQYSFIHSAVLEALTCGNTEIQSEKYNQAMQKL
..|||| || |||.|||.|..|.. |. . ||. |..  .|. |...||   || ||.||.||    |....    .   ...|
ivvhcsaGvGrtGvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalleehlfghsdvampdfpayleel
0040439 (Phosphotyrosine protein) phosphatases II 157-391 4.1e-76 251.1 In-house 10-246 (249) alignment 
Range on Protein: 157-391
Range on HMM: 10-246/249.0
KNKNKNRYANIVAYDHSRVVLERVNGDEDLDYINASFIHGYDGTPRsFIASQGPLPPAFEGFWRMVWEQNSQSIVMLTNLVGLNKTKCHKYWP-DKTETY
.||.|||| .|..||||||.|. ..| .. ||||||.|.||. ..| ||| ||||| ..| ||||.||.....|||||.|| |.. ||..||| ... .|
enkdknrypdilpydhsrvklsilpglflsdyinAsyidgyyikrr.fiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywplggsley

GGVTVTLHQSEVFAGYENCTFILSKEKRSGSRIVRQFHFTVWPDKGVPQYATAVLAFRRKVRALNPR--DAGPVIVHCSVGVERTGAYIVIDAMLEQAKK
|..|||| . ||...|   |. |.. . . || |.....| ||| |||..   .|.| ..||  . .  . |||.|||| || |||..|... |||| .|
gdftvtllsvevkddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaaylmleqlek

SRTVDIRNYLIAIRKHRPHMVQTKEQYSFIHSAVLEAL
 ..||. ...  .|..||..||. ||| |.. |.|| |
elgvdleeavkllrsqRpgavqnpeqyrflyeallell
0042113 (Phosphotyrosine protein) phosphatases II 157-390 2.9e-75 248.1 In-house 8-242 (245) alignment 
Range on Protein: 157-390
Range on HMM: 8-242/245.0
KNKNKNRYANIVAYDHSRVVLERVNGDEDLDYINASFIHGYDGTPRsFIASQGPLPPAFEGFWRMVWEQNSQSIVMLTNLVGLNKTKCHKYWP-DKTETY
.||.|||| .|..|||.||.|  ..||.|.||||||...||. ||. |||.|||||  .| ||||.||.....|||||... |.. ||..||| . . ||
enkdknrysdilpydhtrvklspdggdldsdyinasyvdgyritpk.fiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywplgeslty

GGVTVTLHQSEVFAGYENCTFILSKEKRSGSRIVRQFHFTVWPDKGVPQYATAVLAFRRKVRALNP-RDAGPVIVHCSVGVERTGAYIVIDAMLEQAKKS
|..||||   |....|   |. ..... . || |...|.. ||| ||| .   .| | . ||      . |||.|||| || |||..|... ||||..| 
gdftvtllseehlddytvrtlevtnlgddesrevihyhylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylmleqleke

RTVDIRNYLIAIRKHRPHMVQTKEQYSFIHSAVLEA
..|.. . .  .|..||..||| .|| |.. |.|| 
lgvsleeavkelrsqRpgavqtpsqyrflyeallel
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 156-410 5e-75 247.6 In-house 23-274 (284) alignment 
Range on Protein: 156-410
Range on HMM: 23-274/284.0
NKNKNKNRYANIVAYDHSRVVLERVNGDEDLDYINASFIHGYDgTPRSFIASQGPLPPAFEGFWRMVWEQNSQSIVMLTnlvglnKTKCHKYWPDKT-ET
..||.|||. .|.|.|...| |||. | |  |||||||| ||   .  .||.||||. . . ||||.||.|. .||.||      | || .||| |. ..
dqnkdknrighilafdknvvklerliGeefsdyinasfitGyq.rkdkyiatqGPldntladfWrmiweyncstivllt......kdkcsqywplkivik

YGGVTVTLHQSEVFAGYENCTFILSK-EKRSGSRIVRQFHFTVWPDKGVPQYATAVLAFRRKVRALNPRDAG--PVIVHCSVGVERTGAYIVIDAMLEQA
..   | ..  |  . |    . ||.  |  . | .|||||  |||.|||.|.. .... .||| |. .  .  ...|||| || |||.|||.|..|.. 
eerfkvkvdsveeseeyvvrdielsedgkekdirkirqfhflgwpdvgvpdypsdlmrlvkkvrhltskenhranivvhcsagvgrtgvyivldvlldrm

KKSRTVDIRNYLIAIRKHRPHMVQTKEQYSFIHSAVLEALTCGNTEIQSEKYNQAMQKL
|. . ||. |..  .|. |...||   || ||.||.||    |....    .   ...|
keekqvdvynfvrdlrqqrntlvqdlvqykfiysalleehlfghsdvalpdfpayleel
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 113-403 1.9e-74 245.5 In-house 8-296 (297) alignment 
Range on Protein: 113-403
Range on HMM: 8-296/297.0
KPIPIALFPEYVAKMHggiRLETEYKKFNNGQQFPWGAARKPANK-NKNKNRYANIVAYDHSRVVLERVNGDEDLDYINASFIHGYDGtprSFIASQGPL
.|||.. |. .| | .   . . ....|.   .    .. .  .| | .|.||.||. || ||| |. || | | ||.||||..|.      .|..| | 
rpiplsdfatlvqknr...htdvfseeflclpeaniqpqtvaekkvnfeksRYkniLPydssRvkLaivnddpdsDyvnasfvkgnkh...rlittqmPm

PPAFEGFWRMVWEQNSQSIVMLTNLVGLNKtKCHKYWPDKT-ETYGGVTVTLHQSEVFAGYENCTFILSKEKRSGSRIVRQFHFTVWPDKGVPQ--YATA
. . . ||.||.... . ||||...   .| || .||.||.  |.| |.|.|.  .   |. . .. ..|.|    |.|.|..|. |||| |..   |..
katvadfWamvldeqvstivmlnddnerdk.kcaryWsdkgvttfGdvsvvllsvsereGfikrelevtkgkakarrvvkqyqfveWPdkaverkdsass

VLAFRRKVRALNPRDAG-PVIVHCSVGVERTGAYIVIDAMLEQAKKSRTVDIRNYLIAIRKHRPHMVQTKEQYSFIHSAVLEALTCGNTEIQSEKY
.| .   ||      |  |..|||. || ||| .. || .. .||.  .||| ...  .|..||..|||||||.|.. |||||| . .|.||.. .
llklisevrkdfsqnaegPllvhclaGvGrtgvlltidsvvaeakrekevdifglvkklrqerpylvqtkeqykfvyvavleallsedtriqasyf
0045098 (Phosphotyrosine protein) phosphatases II 157-394 3.4e-74 245.0 In-house 32-275 (278) alignment 
Range on Protein: 157-394
Range on HMM: 32-275/278.0
KNKNKNRYANIVAYDHSRVVlervngdedlDYINASFIHGYdgtPRSFIASQGPLPPAFEGFWRMVWEQNSQSIVMLTNLVGLNKTKCHKYWPDKT-ETY
.|..|||| .|..||||||.          ||||||.|.||   |. ||| |||||  .. ||||.||.....|||||.|| |.. ||..|||..  .||
gnldknRykdilpydhsrVk..........dYINAsyidgy...pkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrekcaqywpeggslty

GGVTVTLHQSEVFAGYENCTFILSKE----KRSGSRIVRQFHFTVWPDKGVPQYA--TAVLAFRRKVRALNPR-------------DAGPVIVHCSVGVE
|..|||| . ||.  |  .|...       .   || |...|.. ||| ||| .   . .| . . .|. . .             . |||.|||| || 
gdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsggpvlVHCsaGvg

RTGAYIVIDAMLEQAkkSRTVDIRNYLIAIRKHRPH-MVQTKEQYSFIHSAVLEALTCG
|||...... |||.    ..||. ...  .|..||. .||..||| |.. ..|| | .|
RtGtlvaaylmlell..eggvdlleavkelrsqRpglavqnleqyrflyefllelllrg
subfamily_PTPN6_pd Subfamily PTPN6 151-390 4.5e-72 237.6 In-house 49-296 (306) alignment 
Range on Protein: 151-390
Range on HMM: 49-296/306.0
ARKPanKNKNKNRYANIVAYDHSRVVLErVNGDEDLDYINASFIH-GYDGTPRSFIASQGPLPPAFEGFWRMVWEQNSQSIVMLTNLVGLNKTKCHKYWP
..||  .||.|||| ||. .||.||.|.  ..  . |||||..|.    |. .|.||.|| |.   . ||||||..||. |||.|. |  .| || .|||
gakp..enkeknryknilPfDhtrvilk.epsvpgsdyinanyikkevkgsdksyiatqgclettvsdFWrmvwqensrvivmttkevErgkekCarYWP

DKT--ETYGGVTVTLHQSEVFAGYENCTFILS-KEKRSGSRIVRQFHFTVWPDKGVPQYATAVLAFRRKVRA----LNPRDAGPVIVHCSVGVERTGAYI
|..  |.|| ..||  ...  | |.  .. .| |.| . .| |.|.||..|||.|||.   |||.| ..|..    |. ..|||..|||| |. |||..|
deeekeeyGkisvtnvseksladYilRelsvskkkkkkeerevfqyhfksWPdhgvpkdpgavLdfledvnrkqeeleeaeagpivvhCsaGiGRtGtfi

VIDAMLEQAKKS---RTVDIRNYLIAIRKHRPHMVQTKEQYSFIHSAVLEA
|||..|.. .|.     .||..    .|..|  .|||..|| |.. |. . 
viDillkliekkgldadidiqklvksvreqrsglvqteqqykfvykaikky
subfamily_PTPN12_pd Subfamily PTPN12 133-392 5.6e-72 237.1 In-house 17-278 (290) alignment 
Range on Protein: 133-392
Range on HMM: 17-278/290.0
LETEYKKFNNGQQFPWGAARKPanKNKNKNRYANIVAYDHSRVVLERVNGDEDLDYINASFIHGYDGTpRSFIASQGPLPPAFEGFWRMVWEQNSQSIVM
| .. .|. . ....  |..|.  .|..|||| .|. ||.|||.|.. ...|. |||||.||.| .|.  ..||.||||| . . ||||.||.| . .||
lkklsekykaekvysteageke..envkknrykDilPydksrvelskieeeegsdYinanfikgvegk.leyiaaqgPLpktlddfWrmiweknveivvm

LTNLVGLNKTKCHKYWPDKT---ETYGGVTVTLHQSEVFAGyENCTFILSKEKRSGSRIVRQFHFTVWPDKGVPQYATAVLAFRRKVRALNPRDAGPVIV
. ..| |.|.||..|||...    ..| ..|||.. . .   .     |  |... ||.|.|||.| |||.|||. |. .|.. ..|| |. ... |..|
aCrevelgkkkCerYWpeegeeelefgefevtleeekavdd.dflirtLkveaqkesrkvyqfhYtaWPDhgvPssaksllelielvrelqesedaPlvv

HCSVGVERTGAYIVIDAMLEQ---AKKSRTVDIRNYLIAIRKHRPHMVQTKEQYSFIHSAVLEALT
||| || |||. |.|| . |.    | . ..|. . .. .||.|. .|||||||.... ||.| ..
hCsaGvGrtGtiiaidyvrellkaekipeeldvfdlvlelrkqraalvqtkeqyelvykavaelvq
0037934 (Phosphotyrosine protein) phosphatases II 157-389 3.2e-69 228.5 In-house 9-240 (243) alignment 
Range on Protein: 157-389
Range on HMM: 9-240/243.0
KNKNKNRYANIVAYDHSRVVLervngdEDLDYINASFIHGYDgtpRsFIASQGPLPPAFEG----FWRMVWEQNSQSIVMLTNLVGLNKTKCHKYWPDKT
 |..|||| .|..||||||.|      |. |||||..| ...   | .||.|||||  .|     ||||.||.....|||||.|| |.. ||..|||...
enlsknrysdilpydhsrvkl......egsdyinanliyvtp...r.liatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywpgev

eTYGGVTVTLHQSEVFAGYENCTFILSKEK-RSGSRIVRQFHFTVWPDKGVPQYATAVLAFRRKVRAL--------NPRDAGPVIVHCSVGVERTGAYIV
 |||..|||| ..|....|   |. |.  .    .| |...|.. ||| |||.  . .|.| ..||.         .  . |||.|||| || |||..|.
.tygdftvtllseehlddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRtGtlia

IDAMLEQAkksrTVDIRNYLIAIRKHRPH-MVQTKEQYSFIHSAVLE
.. ||..     .||. ...  .|..||. .||| .|| |.. |.||
aylmllll....gvdleeavkllreqRpgkavqtpsqyrflyealle
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 113-416 8.1e-68 223.6 In-house 2-262 (392) alignment 
Range on Protein: 113-416
Range on HMM: 2-262/392.0
KPIPIALFPEYVAKMHGGIRLETEYKKFNNGQQFPWGAARKPANknKNKNRYANIVAYDHSRVVLERVNGDEDLDYINASFIHGYDGTpRSFIASQGPLP
.|||.| || .| | .    .  |.. . . . .|  .|.|. |  ..|||| ||. || .||.|| ..   | ||.|||.|...|   ...|||||| .
qpipvaqfpafveknrhsalffeefhdlpgpdiypqtvaqkein..lkknryknilpydsarvkleviddipdsdylnasyipsfdne.kayiasqgpna

PAFEGFWRMVWEQNSQSIVMLTNLVGLNktkchkywpdktetyggvtvtlhqsevfagyenctfilskeKRSGSRIVRQFHFTVWPDKGVPQYATAVLAF
 ... |||||...|  .|.|.|.|   .                                         |    | | ||||| ||||.||......| |
aslddfwrmvfqenvttiamvtklkegd.........................................kgddartvaqfhftewPdkdvpkhtssllkf

RRKVRALNPRDAGPVIVHCSVGVERTGAYIVIDAMLEQAKKSRTVDIRNYLIAIRKHRPHMVQTKEQYSFIHSAVLEALTCGNTEIQSEKYNQAMQKLA-
 ..|.|   . . |.|.||| || |||  | ||... .|||.| ||. |..  ||..||.||||||||.||. |||| |   || |   .. . .|.|  
ikevkadfGqythpliihcsagvgrtgvvisidsvvahakktrmvdvfnfvtnirrkrpymvqtkeqyafiygavledllwrntlipvvhftdhlqdlst

SVNGK
|..|.
ssdGd
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 156-389 4.2e-67 221.1 In-house 26-266 (274) alignment 
Range on Protein: 156-389
Range on HMM: 26-266/274.0
NKNKNKNRYANIVAYDHSRVVLERVNGDE-DLDYINASFIHGYDGTPRSFIASQGPLPPAFEGFWRMVWEQNSQSIVMLTNLVGLNKTKCHKYWPDKTET
 ....|||| .|.  ..|||.||. .... |..|||| .|.|||.. . ..| ||||| . . ||||......| |||||.|   |..||..|.||....
fgsqtknryktilPnensrvllesessededssyinanyikGydeeskayvatqGPlpntvadfWrmiyqeevqvivmltklkeaneqkCavyfPdaedy

-----YGGVTVTLHQSEVFAGYENCTFILSKEKRsgSRIVRQFHFTVWPDKGVPQYATAVLAFRRKVRALNPR---DAGPVIVHCSVGVERTGAYIVIDA
     ||.| .. ..     .|.  ...|.. .|  .| |  . .| |||. .|. |...| . ..|.  . .    ..||.|||| |. |||..| |. 
eiserygdveikvekiverndysvrklvlkyler..ersvkhywytdWPdhksPddantlldlvleveesreeenaklapvvvhCsaGiGrtGcfiaisi

MLEQAKKSRTVDIRNYLIAIRKHRPHMVQTKEQYSFIHSAVLE
 . | ... .||. .    .| .|  ||||.||| .|| |. .
avrqlreeivvdvlkivcnlrldrGGmvqtseqyelihralcl
subfamily_PTPN9_pd Subfamily PTPN9 133-389 4.3e-67 221.2 In-house 18-288 (297) alignment 
Range on Protein: 133-389
Range on HMM: 18-288/297.0
LETEYKKFNNGQqfPWGAA-RKPANKNKNKNRYANIVAYDHSRVVLERVNGDEDLDYINASFIHGYDgTPRSFIASQGPLPPAFEGFWRMVWEQNSQSIV
|  ||..  | .  . | . .   . | .||||.... ||..||||..|..||  |||||.|. ||   ...||| ||||. ... ||||||||.   ||
lskeyaeirnep..veGtflasklranleknrytdvlcydetrvvlakvdedeasdyinanfvdGyk.qkkafiatqGplkktvsdfWrmvWeqevlviv

MLTNLVGLNKTKCHKYWP---DKTETYGGVTVTLHQSEVFAGYENCTFILSKEKRSGSRIVRQFHFTVWPDKGVPQYATAVLAFRRKVRA--------LN
| | .|   . || .|||   .... .| ..|.  . |.   |.  .. ... | . || |  | |. ||| |||. |...| ...|||         | 
mttrvvergrlkcgqyWpleeessaefgdlsvsnveveeeedykvrvleiknvkteesrkvthfqflsWPdyGvPssaaslldvlekvrekqalavkelg

PRDA-----GPVIVHCSVGVERTGAYIVIDAMLEQAKKSRTVDIRNYLIAIRKHRPHMVQTKEQYSFIHSAVLE
....      |..|||| |. |||..| .|  |.. ..  |||... .  .|. | ...|| ||| | . ||||
dewkghpsgPPivvhcsaGiGrtGtfitldiclsrleevgtvdvvetvkllrtqrafsiqtpeqyefcylavle
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 149-420 7.8e-67 220.7 In-house 41-314 (325) alignment 
Range on Protein: 149-420
Range on HMM: 41-314/325.0
GAARKPANKnkNKNRYANIVAYDHSRVVLERVNGDEDLDYINASFIHGYDGTpRSFIASQGPLPPAFEGFWRMV--WEqnsQSIVMLTNLVGLNKTKCHK
 .| ||.||  .|||. |.||.|.||||||  . | . ||||||... . .    |.|.| ||. . . .||.|  |.    |.|...| . |.| .| .
kvamkpenk..aknrfknvvaldksrvvletkkddpssdyinasylrddkkk.dvflaaqaPltatindlWrlvldWr...csvvvvlneldlgkdrcav

YWPDK---TETYGGVTVTLHQSEVFAGYENCTFILSKEKRSGSRIVRQFHFTVWPDKGVPQYATAVLAFRRKVRAL------NPRDAGPVIVHCSVGVER
|||..   . |.||. | |   | .. |    . . . |.  .| |.||..  |.| ||... ...... . | |.      | . ..|..|||| || |
ywpkemgksktfGglevklrtieeisdyvhrvldvkqvkkGetrsvkqfqlqswddmGvqkrpatlisilqlvkavservtantkastpilvhcsaGvGr

TGAYIVIDAMLEQAKKSRTVDIRNYLIAIRKHRPHMVQTKEQYSFIHSAVLEALTCGNTEIQSEKYNQamqKLASVNGKFPMT
||..| . ..|..  .   ||| ...  .||.|| ||.| .||..|. |. ||. .|||..    ..    ||.|.. . |.|
tGvfislysalakvieesrvdifgfvkklrkdrpsmvetvdqyiliyealveaymsgntdvpvssfea...klsslqernplt
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 115-395 1e-66 219.8 In-house 2-287 (290) alignment 
Range on Protein: 115-395
Range on HMM: 2-287/290.0
IPIALFPEYVAKM--HGGIRLETEYKKFNNGQQfPWGAARKPANKNKNKNRYANIVAYDHSRVVLERVNGDED--LDYINASFIHGYDGTpRSFIASQGP
||.  | |.||.   .|  . ....|....|.. .  . .. ...||..||.|||| ||  |..| ...|..|   .||||..|.||    ...|| |||
ipvdkfgefvanghakgnegfrnqfkmldsges.ehtvtvgltssnkllnRfanivvyddnritLrpisghkDCtneyinAcyikgykek.kqyiatqgp

LPPAFEGFWRMVWEQNSQSIVMLTNLVGLNKTKCHKYWPDK-TETYGGVTVTLHQSEVFAGYENCTFILSKEKR-SGSRIVRQFHFTVWPDKG-VPQYAT
..     ||...|....  |||||| .  .|.||..||||. |..|| ....|.. |.. .| . .. . ...    ...| |...| |...| |....|
vsntlvdFWkliwqekvtiivmltniieegkvkCqqYWpdsdtkaygefsikllneetlneyierklevknknsagakqsvtqyqitnwdstgkvtnpqt

AVLAFRRKVRALNPRDAGPVIVHCSVGVERTGAYIVIDAMLEQAKKSRTVDIRNYLIAIRKHRPHMVQTKEQYSFIHSAVLEALTCGN
 .|.... ..    |  ....|||| .| |.. .....  ....|.   .|. . |   |  .| .|||..|| .|.. ||..|.. .
illvieemyktqrkrgntsivvHCSdtvgrsavfcaaattinkcktegvidvfqvlksqRiqkpgsvqtvqqyqgifqivltyldsfe
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 115-398 3.4e-66 218.2 In-house 2-285 (287) alignment 
Range on Protein: 115-398
Range on HMM: 2-285/287.0
IPIALFPEYVAKMH--GGIRLETEYKKFNNGQQFPWGAARKPANKNKNKNRYANIVAYDHSRVVLErvngDEDLDYINASFIHGYDGTpRSFIASQGPLP
||.  | |.||| |  |    .. .. ... .| .     . |..||.|||...|. .|  ||.|.    .|. |||||.|| ||    . ||....|. 
ipvekfgefvakghakgnegfknqftvleqvtqredevthniasqnkdknRltqilvpdnyrvllk....gehpdyinavfidgykek.kafiiaesPmf

PAFEGFWRMVWEQNSQSIVMLTNLVGLNKTKCHKYWPDKT-ETYGGVTVTLHQSEVFAGYENCTFILSKEKRSG-SRIVRQFHFTVWPDKG-VPQYATAV
 .   ||......| . ||||...   .. .|..|||...  ..|  ...| . || ||| . .. . .....|  . |.|...| |...| |....| .
ntarnfWkliddrnvtaivmlcqekendeevcyqyWpeeksvvlGeyniellneevnagyierklevknknkagdkqqvkqyqitnWdstgkvtepqtil

LAFRRKVRALNPRDAGPVIVHCSVGVERTGAYIVIDAMLEQAKKSRTVDIRNYLIAIRKHRPHMVQTKEQYSFIHSAVLEALTCGNTEI
| . .....   |  ....|||| .| |.. .. ..  ....|.  ..|. . |   |  .|..||| ||| ||  .||| |....|  
lvieemyktqrkrgntsivvhCsdtvGrsamfcaaattinkckteGviDvfqvlksqriqkpgsvqtveqykfindivleyldsfetys
subfamily_PTPN1_pd Subfamily PTPN1 141-399 2e-64 212.1 In-house 17-281 (290) alignment 
Range on Protein: 141-399
Range on HMM: 17-281/290.0
NNGQQFPWGAARKPANknKNKNRYANIVAYDHSRVVLERVNGdedlDYINASFIHgYDGTPRSFIASQGPLPPAFEGFWRMVWEQNSQSIVMLTNLVGLN
.. ..||  .|..|.|  .|.||| ..  |||||..||| .     ||||||...  .   ||.| .||||| . . ||.|||||.|...||| ..|  .
keasdfptreaklpen..rnlnryrdvspydhsrikleradn....dyinaslve.leeakrsyiltqGPlpntvdhfWqmvWeqkskavvmlnkvveke

KTKCHKYWPDKTE----TYG--GVTVTLHQSEVFAGYENCTFILSKEKRSGSRIVRQFHFTVWPDKGVPQYATAVLAFRRKVRAL--NPRDAGPVIVHCS
..||..||| . |    ..    ..|.| . |.   |   .. | . |   .| . .||.| ||| |||.  .| | |  |||      .| ||...|||
qikcaqywPqgeeekellledtklkvkliseerksyytvrllelenlktqetreilhfhyttwpdfgvpespaaflkflfkvresGslssdvGpavihcs

VGVERTGAYIVIDAMLEQAKKSR---TVDIRNYLIAIRKHRPHMVQTKEQYSFIHSAVLEALTC--GNTEIQ
 |. |.|.....|..| . .|.    .|||.. |...||.|  ..||..|  | . |.||   .  |.. .|
aGiGrsGtfclvdtclvliekkddlssvdikkvllelrkyrlGliqtadqlrfsylaileGakvikgdssvq
subfamily_PTPN3_pd Subfamily PTPN3 148-390 1.4e-63 209.5 In-house 33-274 (280) alignment 
Range on Protein: 148-390
Range on HMM: 33-274/280.0
WGAARKPANKnkNKNRYANIVAYDHSRVVLERVNGdedlDYINASFIHG-YDG--TPRSFIASQGPLPPAFEGFWRMVWEQNSQSIVMLTNLVGLNKTKC
  |||||.|   .|||| .|..||. || |.  .     |||||...    ..  .   .||.||||. . . ||.|||||.|. |||||.||   ..||
isaarkpenl..sknryrdilpydatrvklkeset....dyinanyvnmeipstglvnryiatqGPlaktatdfWqmvweqksslivmlttlverGrvkC

HKYWPDKTE--TYGGVTVTLHQSEVFAGYENCTFILSKEKRSGSRIVRQFHFTVWPDKGVPQYATAVLAFRRKVRALNPRDAGPVIVHCSVGVERTGAYI
|.|||....  .||. .|......    |    ..|.... . .| . |. .. |||.|||. .. .| | ..||.|   .  ||.|||| |..||| .|
hqyWPetedeleygefsvkcekedetksyvlrelvlkdketkeerkilqlqylaWpdhgvPddsadflefvervrklrsgkeePvvvhCsaGigrtGvli

VIDAMLEQAKKSRTVDIRNYLIAIRKHRPHMVQTKEQYSFIHSAVLEA
...  |    ... | . . .  .|  |  .|||..|| |.  |.|..
lletalalieaaepvypldivrtmrdqramlvqtasqykfvCeailkv
subfamily_CG7180_pd Subfamily CG7180 156-395 6.9e-63 207.0 In-house 40-294 (296) alignment 
Range on Protein: 156-395
Range on HMM: 40-294/296.0
NKNKNKNRYANIVAYDHSRVVLERVNGDEDLDYINASFIHGYDgTPRSFIASQGPLPPAFEGFWRMVWEQNSQSIVMLTNLVGLNKtKCHKYWPDK-TET
..|..|||. ..| ||. |||||...|.|. |||||... ..   .. .|  ..|   . . |||.|........|.||.    .| ....||| |  | 
kenreknrdvkvvPyDynRvvLekldGeeksdYinavyvdsfl.kkkeyivteapkketvdefWrlvydeeisavvvLtktfdfak.mypsywpnkskeq

YGGVTVTLHQSEVFAGYENCTFILSKE----------KRSGSRIVRQFHFTVWPD-KGVPQYATAVLAFRRKVRALNPRD-----AGPVIVHCSVGVERT
|| . | . ... .|  .  || | |.               |||..|..|.|.  . ||  ..|.. .||.|| .  .       |||.|..| |. |.
ygeifveiveekqyanlkirtfkltkkivalteqekqvkaetRivklfqlteWeledkvPlstnalielrrrvrlwrekvdedpeegPvvvvssdGasRs

GAYIVIDAMLEQAKKSRTVDIRNYLIAIRKHRPHMVQTKEQYSFIHSAVLEALTCGN
|.|. ||| ||...|   ||. ...  .|..||..|...|.| .|   .|||. |. 
GvylaidanlelvekeeevdvFeavktlrrsRpqLvenveeYkyiYdvlleavlcnk
subfamily_PTPN13_pd Subfamily PTPN13 154-392 8.2e-63 207.2 In-house 33-270 (273) alignment 
Range on Protein: 154-392
Range on HMM: 33-270/273.0
PANKNKNKNRYANIVAYDHSRVVLERVNGdedldYINASFIHGYDGTP-RSFIASQGPLPPAFEGFWRMVWEQNSQSIVMLTNLVGLNKTKCHKYWPDKT
  ..||.|||| |.. ||..|| |.   |     |||||.|.   |    ..||.||||| . . ||.|||||... |.|.|. .  .| |||.|||...
kkkenkdknryrnvlPydetrvklgdegg.....yinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweqkaeviamvtlekekgkvkchrywPesk

E----TYGGVTVTLHQSEVFAGYENCTFILSKEKRSGSRIVRQFHFTVWPDKGVPQYATAVLAFRRKVRALNPrDAGPVIVHCSVGVERTGAYIVIDAML
.     .. ..|.| . .   |.   .. ... . . || | ...|. ||| |||. |. .| | ..|| |.  ||||..|||| |. |.|..|.||..|
nkklkvsnrlevellkvqkldgfvvralavkdsesgesrevahlnfvkwPdhgvPssaaellqfvaevrrlqt.dagPivvhcsaGiGrsGtlitidvvl

EQAKKSRTVDIRNYLIAIRKHRPHMVQTKEQYSFIHSAVLEALT
.  .. . .|... .  .|. |  .||||.|| |.. |.||.|.
glierdkefdvkeivrklreqrqgvvqtkdqyifvykailevlk
subfamily_PTPRN_pd Subfamily PTPRN 132-390 9e-62 203.4 In-house 30-291 (297) alignment 
Range on Protein: 132-390
Range on HMM: 30-291/297.0
RLETEYKKFNNGQQFPWGAARKPANKNKNKNRYANIVAYDHSRVVLERVNGDEDLDYINASFIHGYDGTPRSFIASQGPLPPAFEGFWRMVWEQNSQSIV
||| |.. . . .. |  ..   |.|| .|||......|||||| |.. . .|. ||||||.|   |    ..||.||||.     ||.||||| .  ||
rlekewealcayeaepstkevakaeknvkknrskavlpydhsrvklkeeasaeksdyinasaildhdprapayiatqgplastvadfwqmvweqGvvviv

MLTNLVGLNKTKCHKYWPDK-TETYGGVTVTLHQSEVFA-GYENCTFILSKEKRSGSRIVRQFHFTVWPDKGVPQYATAVLAFRRKVRALNPRDAGPVIV
.||.|   . ..|..||||. .|.|.   | |    ...  |   .| |   . | .| | ||||  ||..|||  | ..| |||||       . |..|
nltrleeegvkqckrywpdeGsevyhiyevhlvsehiwcddylvrsfylknlqtsetrtvtqfhflswpeegvPasaksllefrrkvnksyrGrscpivv

HCSVGVERTGAYIVIDAMLEQAKK-SRTVDIRNYLIAIRKHRPHMVQTKEQYSFIHSAVLEA
||| |. |||.||.|| .|.. .|  . .||   |  .|  ||..|.||.|. |. .|| | 
hcsdGaGrtGvyilidlvlnrllkGvkeidiaatlehlrdqrpglvktkdqfefaltavaee
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 156-389 1.2e-61 203.1 In-house 18-262 (270) alignment 
Range on Protein: 156-389
Range on HMM: 18-262/270.0
NKNKNKNRYANIVAYDHSRVVLERVNGDEDLDYINASFIHGYDGTPRSFIASQGPLPPAFEGFWRMVWEQNSQSIVMLTNLVGLNKTKCHKYWPDKTET-
 ..|. ||||.|.   ..||.||... |.   |||| ...|.|| ....||..|||| . . ||||.||.....|||.|.|.  ...|| .||| .... 
argkklnRyadiLPsPatRvrleeleedsataYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkgrkkCerYWpaepkek

----YGGVTVTLHQSEVFAGYENCTFILSkEKRSGSRIVrQFHFTVWPDKGVPQYAT------AVLAFRRKVRALNPRD--AGPVIVHCSVGVERTGAYI
    .| ..|.  ..|   ||      |  || .  |.|  |... |||.|||. .        .|.  |.||. . .   |.|..|||| ||.|||  |
vkledgkikvlalseekeegyiltrlrle.ekgeerrlv.HfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkaePllvHcsaGvgRtGtli

VIDAMLEQAKKSRTVDIRNYLIAIRKHRPHMVQTKEQYSFIHSAVLE
..| ...  .... ||. . . ..||.|. .||. ||| |.. ||.|
alDiavrlLeetkkvdvlaiieelRkdRmalvqhpeqyeflykavve
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 157-405 2.7e-60 199.1 In-house 47-293 (439) alignment 
Range on Protein: 157-405
Range on HMM: 47-293/439.0
KNKNKNRYANIVAYDHSRVVLERVNGDEDLDYINASFIHGYDgTPRSFIASQGPLPPAFEGFWRMVWEQNSQSIVMLTNLVGLNKtkchkYWPDKTETY-
 .. |||| ...|.||.||.|. . |     |||| .|.||  ... .||.|||   . . |||.|.|...  ||||||||   |     ||| ..|.. 
ydqtknrykdvgafdhtrvtlqeipgvphshyinanyikGyy.ddklyiatqgpkkettddfwrlviekktvtivmltnlvesyk.....ywpsdaevcy

GGVTVTLHQSEVFAGYENCTFILSKEKR--SGSRIVRQFHFTVWPDKGVPQYATAVLAFRRKVRALNP-RDAGPVIVHCSVGVERTGAYIVIDAMLEQAK
| ..|   .   .  |    | . .|.      | | |||.. |||| ||  |. || | | . . |  .. |||.|||| || |||. | .|  ||| |
gdiavrvdrnielpnyvirgfkvfnerdttekertvlqfhyiawpdknvpaqashvldflrainsandkeeygpvvvhcsagvGrtGtiialdialeqlk

KSRTVDIRNYLIAIRKHRPHMVQTKEQYSFIHSAVLEALTCGNTEIQSEKYNQ
    |||.  .  .||.| .|||.  || ||. |||| .  |.. .. .....
lenkvdikgivkvlrkqrkqmvqalcqyvfiynavledivyGdiavtidefkk
subfamily_PTPN23_pd Subfamily PTPN23 132-390 6.4e-57 187.6 In-house 16-279 (288) alignment 
Range on Protein: 132-390
Range on HMM: 16-279/288.0
RLETEYKKFNNGQQFP-WGAARKPANKNKNKNRYANIVAYDHSRVVLErvnGDEDlDYINASFIHGYDGTPRSFIASQGPLPPAFEGFWRMVWEQNSQSI
 |....|.... |.    . .   |... .|||. .|. |||.||.|.   | .| |||||||...   .  .|||.|.||...   ||.||.|| |. |
aldkkfkeleqkqdkearkrsiaiaklyseknrsrdilPyDhnRvklr...gskD.DYinAsfvkdlspgcPdfiatqaPlqstlnDFWlmvyeqkssvi

VMLTNLVGLNKTKCHKYWP---DKTETYGGVTVTLHQSEVFAGYENCTFILSKEKRSGSRIVRQFHFTVWPDKGVPQYATAVLAFRRKVRA----LNPRD
|||..   |.|.|...|||   ..|...| ..|||.. .    . . ...|. .. .  . |.  ..| ||. |||.    .|.|  .|..     . . 
VmllskeelgkpkvdrYwPedkgetvkfgdlsvtlksvretethvervlkletldadavksvshlqltsWpelGvPasPetllqfldevesayeavqrks

AGPVIVHCSVGVERTGAYIVID-AMLEQAKKSRTVDIRNYLIAIRKHRPHMVQTKEQYSFIHSAVLEA
  |..|||| ||.|||.. ..  |. |  |.   .|| . .  .|. | .|||.|||. |  .|||||
ktPlvvhCsaGvgRtgvfalvyaavrelekgnglldiiqvvsrlreqRrfmvqekeqlkfsyeavlea
0051299 (Phosphotyrosine protein) phosphatases II 394-623 4.2e-54 179.3 In-house 1-227 (288) alignment 
Range on Protein: 394-623
Range on HMM: 1-227/288.0
GNTEIQSEKYNQAMQKLAsvngKFPMTGYALEFQRLNSVTSReipvEEKSVGEKPQNLHKNRFSDIIALNSCRVMLHKEHADEESDYINAVFLHAHRGRN
|.|||. |.. ....||     .  .||.. ||..| |..       . |.. .|.||.|||.|||......|| |. .. .|.|||||| ... ..  .
gdteisveellklvlkll....angltglleefeellsllpd....ltlsaallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyidgynlkr

AFIATQHPLLETVEDFWRMVTDYDIGTIVMLNNLHDQVAPESSEYWPDHGATKYGHIGISVLSKQKKGDVICVKPKVT------RKKKTHEVRHLHHVSW
.|||||.|| .||||||||| .... .||||..|..     .  |||..| ..||.| .  || ....|... . .||       ......|.|.|. .|
kfIatqgPlpntvedFWrmvweqnvrvIvmltklvelgrekcaqYwplggsltygditvtllseevlddytvrtlevtnldlldgdgesrtvthfhytnw

TDKCIPKVSRSVLDLLDEVQTSQQqCGNVPVLVQCR
 | ..|   ...||.| .|.....  |. ||.| |.
pdhgvpdspellldflrlvrkala.sgggpvvVHCs
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 133-397 5.4e-54 177.9 In-house 17-299 (301) alignment 
Range on Protein: 133-397
Range on HMM: 17-299/301.0
LETEYKKFNNGQQFPWGAARkpANKNKNKNRYANIVAYDHSRVVLERVNG--DEDLDYINASFIHGYDGTpRSFIASQGPLPPAFEGFWRMVWEQNSQSI
.| .||. ..|.. .        ..||. ||. ||. ||. |..|.  .       .|||||.|.||  . . |||.|||.      |||..|..  .||
feeqykelkegedksctvgl..seenkalnrfknitvyddnriilkpkpnldlcqreyinasyidgysek.kkfiaaqgpmkktlvdfWrliwqekpvsi

VMLTNLVGLNKTKCHKYWPD---KTETYGGVTVTLHQSEVFAG-----------------YENCTFILSKEKrsGSRIVRQFHFTVWPDKGV-PQYATAV
||.|||    |.||..|||.   ..|..| .||||... |.                   | . .|  ...|   |. | |.. | ||. || ....| .
vmvtnlkegtkskceqywpnseaeseefgpftvtlvneqvyPdfvirqlnvkiqdgsnngyierkfkvksdk..sswdvlqlqvtdWpqdGvvreprtvL

LAFRRKVRALNPRDAGPVIVHCSVGVERTGAYIVIDAMLEQAKKSRTVDIRNYLIAIRKHRPHMVQTKEQYSFIHSAVLEALTCGNTE
 .    . . .  . |||.|||| .| |.| |. ..  |||.|    ||. .   |.|. .| .|.| |||..|. .. . |.. .|.
qviddvihrqqkigggpvvVHCSdtVsrsGvYcsvsiglEQckaegVVdvfqvtkavrrskpgaVtTLeqytsiydvidmylqlnsty
0050432 (Phosphotyrosine protein) phosphatases II 391-623 2.7e-53 176.7 In-house 12-240 (308) alignment 
Range on Protein: 391-623
Range on HMM: 12-240/308.0
LTCGNTEIQSEKYNQAMQKLAS-VNGKFPMTGYALEFQRLNSVTSreipVEEKSVGEKPQNLHKNRFSDIIALNSCRVMLhkehaDEESDYINAVFLHAH
|....|.|. ..... ...|.  ..... ....  ||..|.||.     ..| ||...|.| .|||..||... ..|| |     ||.|||||| . . .
llfrdtsilvsslklsvldllkllekaldlglleeefeellsvkp....lleysvallpenkdkNrykdilpydhsRVkl.....degsdYInAsyvdgy

--RGRNAFIATQHPLLETVEDFWRMVTDYDIGTIVMLNNLHDQVAPESSEYWPDH---GATKYGHIGISVLSKQKKGDVICVKPKVTR--KKKTHEVRHL
  . ...|||||.|| .||||||||| .... .||||..|..   .   .|||.    | ..||.. . .|| ....|... . ..|   ......|.|.
ssklprkfIatqgPlpntvedFwrmvweqnvrvIvmLtklvengrekcaqYwplelgggsleygkftvtllseevlddytvrtleltnlgdgesrtvthf

HHVSWTDKCIPKVSRSVLDLLDEVQTSQqqcGNVPVLVQCR
|. .| | ..|   ...||.|..|..|.   .. |..| |.
hytnWpdhgvPpspeilldflelvrksl...pggpivVHCs
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 151-399 1.3e-51 170.2 In-house 26-274 (283) alignment 
Range on Protein: 151-399
Range on HMM: 26-274/283.0
ARKPANKNKNKNRYANIVAYDHSRVVLERVNGdedlDYINASFIH--GYDGTPRSFIASQGPLPPAFEGFWRMVWEQNSQSIVMLTNLVGLNKTKCHKYW
  . |..||.|||. .||..|  || |.  .     |||||.||     .   . .|..|.||  .   ||.||....  .|||||.|   .. || .||
diasadenkrknrnqeivpadqwrvelksesr....dyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfdekitaivmltklqedlrikCsqyW

PDK-TETYGGVTVTLHQSEVFAGYENCTFILSKEKRSG-SRIVRQFHFTVWPDKGVPQYATAVLAFRRKVRALNPRDAGPVIVHCSVGVERTGAYIVIDA
| . .| ||  ||||..      .    ..| ..  .  . ..  . .  | . |      ... | . .   .    ||..|||| |. ||...| . |
PkrGsedyGeftvtlrkettsnsfiikelllrvnssakstlllahyqvidWleygeqaiinslvkfnkvislqteskkgPivvhCstgiGrtavfiaasa

MLEQAKKSRTVDIRNYLIAIRKHRPHMVQTKEQYSFIHSAVLEALTCGNTEIQ
 ...|. .  ||. . .  .|..|. .|||..|| ..| .|||   ||.|.| 
svkdaltesvvdvfavvkimreqrmmavqtldqyklvhelvleqalcgdtqia
subfamily_PTPN14_pd Subfamily PTPN14 155-391 3.5e-50 165.7 In-house 46-296 (300) alignment 
Range on Protein: 155-391
Range on HMM: 46-296/300.0
ANKNKNKNRYANIVAYDHSRVVLERVNgDEDLDYINASFIHGY-DGTPRSFIASQGPLPPAFEGFWRMVWEQNSQSIVMLTNLVGLNKTKCHKYWPDK--
 ..|..|||. ... |...|| |   . ... .||||| |.    |. ||.|..||||. . . ||.|||||. | |||||.     |.|..||.|..  
lpenaeknrfkdvlPyednrvelsptk.enstgyinassikvsvggkersyivaqgPleltvqdfWqmvWeqgvqlivmlteeeedgkeksfkyfPkles

---TETYGGVTVTLHQSEVFAGYENCTFILSKEKRSGSRIVRQFHFTVWPDKGVPQYATAVLAFRRKVRALNPR---------DAGPVIVHCSVGVERTG
   | ..|   || . ||    .   .. |     .  | |  . .| |||.|||.  .  | . ..|...  .            ||.|||| || |||
kkktvefgkfkvttkfsedsdsvittglklkhlpskeertvwhlqytDWpdhgvPeDvkgflsyLeevqsvrrktnseveskeskPPvlvhCsaGvGrtG

AYIVIDAMLEQAKKSRTVDIRNYLIAIRKHRPHMVQTKEQYSFIHSAVLEAL
  |. | ...  .. ...||.. |  .|. | ..|||  || |....... |
vlilsdlliatlehneeidikkvlarLreqrmllvqtlaqYkfvYkvlikyl
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 150-388 1.1e-49 163.7 In-house 32-274 (287) alignment 
Range on Protein: 150-388
Range on HMM: 32-274/287.0
AARKPANknKNKNRYANIVAYDHSRVVLErVNGDEDLDYINASFIHGYDGTpRSFIASQGPLPPAFEGFWRMVWEQNSQSIVMLTNLVGLNKTKCHKYWP
|| . |.   .|||||... .|..||.|   .|.   ||||| .. .|     .|||.|||.. .   |||.|.|..| |....|  |   . ||.||||
aaeelaa..vkknryadvlPiddtrvlls.aegelGsdyinanyvasytdd.eafiaaqgPiaatvrdfwravletrsasvitmtreveearlkcykywP

DKTE--TYGGVTVTL-HQSEVFAGYENCTFILSKEKRSGSRIVRQFHFTVWPDKGVPQYATAVLAFRRKV-----RALNPRDAGPVIVHCSVGVERTGAY
..      || .|.|  ..     |   .. | . .   .|.|.|...  ||||...  | ... |  .|      | .  ..||..||..||. |.| .
erevPmrvGGysvvlldydikePeygvralrlidletrearvvkqldllswPdkvlaPtavglirfvldvkqhielardasevGPlvvhddvGiGrsGil

IVIDAMLEQAKKSRTVDIRNYLIAIRKHRPHMVQTKEQYSFIHSAVL
. . ..... ..   ||. . .| .|..|  .||.  |. ..  |. 
latlvlvsrledlGrvdvaavvirlreyraalvqavvqlrllyealv
0046845 (Phosphotyrosine protein) phosphatases II 424-623 2.8e-49 163.4 In-house 4-212 (284) alignment 
Range on Protein: 424-623
Range on HMM: 4-212/284.0
LEFQRLNSVTSREIpvEEKSVGEKPQNLHKNRFSDIIALNSCRVMLHKEHAD-EESDYINAVFLHAH-----RGRNAFIATQHPLLETVEDFWRMVTDYD
 ||..|.|.|   .   . ||. .|.||.|||..||......|| |. .. | |.|||||| ... .     . ...|||||.|| .||||||||| ...
eefeellsltvkll..lslsvallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweqn

IGTIVMLNNLHDQVAPESSEYWPDHG-ATKYGHIGISVLSKQKKGDVICVKPKVTR---KKKTHEVRHLHHVSWTDKCIPKVSRSVLDLLDEVQTSQQQ-
. .||||..|..      . |||. |   .||.. . .||...|.|... . ..|.   ......|.|.|. || | ..|  ....|..|..|...... 
vrvIVmltelvengrekcaqYwplegevltygdftvtllseevkddytvrtleltnlgytgesrtvthfhytswpdhgvppspedlleflrlvrellenl

CGNVPVLVQCR
 |. |..| |.
pgggpivVHCs
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 423-622 4.3e-49 162.3 In-house 23-220 (318) alignment 
Range on Protein: 423-622
Range on HMM: 23-220/318.0
ALEFQRLNSVtsREIPVEEKSvgEKPQNLHKNRFSDIIALNSCRVMLHKEHADEESDYINAVFLHAHRGRNAFIATQHPLLETVEDFWRMVTDYDIGTIV
  |..||. .  .| . . ||   .| | .|||. .|.| ...|| |.. . .|.|||||| ..  .| ..|.||.| || ||.||||||| . .  .||
seeyerlsrs..eetvtslks..lepvnkaknryanilaydhtrvkLqmlegeegsDyinanyidGyrrkkayiaaqaPlpetieDfWrmvWeqnsaviv

MLNNLHDQVAPESSEYWPDHGATKYGHIGISVLSKQKKGDVICVKPKVTRKKK--THEVRHLHHVSWTDKCIPKVSRSVLDLLDEVQTSQQQCGNVPVLV
|| .....       |||..|...||.. . . .. . .| .  . ||||...  . .||  |. ||.|. .|. . |.|||. .|.. ||..|. |..|
mltqeeergkakvhryWPskgsrsygklvvelkeevelsdyvlrefkvtrteeeesrqvrqyhytsWpdegvpesgaslldlvrqvskaqqksgagpivv

QC
 |
hC
0041856 (Phosphotyrosine protein) phosphatases II 158-397 5.2e-49 161.6 In-house 1-177 (182) alignment 
Range on Protein: 158-397
Range on HMM: 1-177/182.0
NKNKNRYANIVAYDHSRvvlervngdeDLDYINASFIHGYDGTPRsFIASQGPLPPAFEGFWRMVWEQNSQSIVMLTnlvglnktkCHKYWPDKTetygg
|..|||| .|. |||||          |||||||... |.  . | ||| ||||.  .. |.||..|.. ..||.||         .. |||..      
nldknrysdilpydhsr..........dldyInanlylgslpatr.fiatqgpllstvadflrmlkelgittivnlt.........eelywpell.....

vtvtlhqsevfagyenctfilskekrsgSRIVRQFHFTVWPDKGVPQyATAVLAFRRKVRAlnprDAGPVIVHCSVGVERTGAYIVIDAMLEQakksrTV
                             | . |.... ||| |||     .|.| ..|..    . |||.|||| || |||...... |...      |
............................erlgiqylylpwpDhgvpd.ldelldfieevle....eggpvlVHCsaGvgRtgtlvaaylmkkl.....gv

DIRNYLIAIRKHRPHMVQTKEQYSFIHSAVLEALTCGNTE
.... .  .|..||.||.| .|| |.. |.|| | ...|.
sleeavklvrsrRpgmvitpnqyfflqlallellllkktr
0047943 (Phosphotyrosine protein) phosphatases II 413-623 1.4e-48 161.1 In-house 5-213 (273) alignment 
Range on Protein: 413-623
Range on HMM: 5-213/273.0
VNGKFPMTGYALEFQRLNSVTSreipVEEKSVGEKPQNLHKNRFSDIIALNSCRVMLhkehADEESDYINAVFLHAHRGRNAFIATQHPLLETVEDFWRM
..... .|....||..| |..     . ..||...|.|..|||..||......|| |     |..|||||| ..  ..  ..|||||.|| .||||||||
lekllgltllleefelllslkp....lltysvallpenkdknrykdilpydhsrvkl....gdggsdyinAsyvdgynlkrkfiatqgPlpntvedfwrm

VTDYDIGTIVMLNNLHDQVAPESSEYWPDHG---ATKYGHIGISVLSKQKKGDVICVKPKVTR--KKKTHEVRHLHHVSWTDKCIPKVSRSVLDLLDEVQ
| .... .||||..|..   .    |||. |    ..||.. . .|| ..|.|..  . ..|.   .....|.|.|. .| | ..|    |.|.....|.
vweqnvrviVmLtelvelgrekcaqYwpleggelsltygkftvtllseetkddytvrtleltnlgtgesrtvthfhytgwpdhgvppslesllefielvr

TSQQQC-GNVPVLVQCR
. .... .| ||.| |.
kalealpsngpvvVHCs
0040438 (Phosphotyrosine protein) phosphatases II 420-623 2.4e-48 160.4 In-house 18-217 (317) alignment 
Range on Protein: 420-623
Range on HMM: 18-217/317.0
TGYALEFQRLNSVtsreiPVEEKSVGEKPQNLHKNRFSDIIALNSCRVMLHKEHADEESDYINAVFLHAHRGRNAFIATQHPLLETVEDFWRMVTDYDIG
|.   ||..| |.     .... ||.|.|.| .|||..||. . ..|| |. .  |..|||||| . . .. ...|||||.|| .||||||||| .....
talleefedllsl.....kldtysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyvdgpnlkrkfIatqgPlpntvedFwrmvweqgvt

TIVMLNNLHDQVAPESSEYWPDHGATKYGHIGISVLSKQKKGDVICVKPKVT--RKKKTHEVRHLHHVSWTDKCIPKVSRSVLDLLDEVQTSQQqCGNVP
.||||..| .   . . .|||. . ..||.. . .|| .......  . .|.  .......|.|.|. .|.| ..|.  ...||.|..|.....  .. |
vivmLteleelgrekcaqYwplgetltygdftvtllseeelagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfleavreale.dpggp

VLVQCR
||| | 
vlVHCs
0051429 (Phosphotyrosine protein) phosphatases II 187-411 2.6e-48 160.3 In-house 5-244 (272) alignment 
Range on Protein: 187-411
Range on HMM: 5-244/272.0
DYINASFIHGYdGT---PRSFIASQGPLPPAFEGFWRMvWEQNSQSIVMLTNLVGLNKTKCHKYWP-------------DKTETYGGVTVTLHQSEVFAG
.||||... || |    |. ...|.||||   ..|||. .|..  .||.|.... ... ||..|||             . | .|| ..|||.. |..  
gyiNardvggy.grvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseellld

YENCTFILSKE-KRSGSRIVRQFHFTVWPDKGVPQYAtaVLAFRRKVRAlnprdAGPVIVHCSVGVERTGAYIVIDAMLEQAKKSRTVD--------IRN
|   ...|... . . .| |...|.| ||| |||| |  .|.. . ...      |||.|||| |. ||| ..... .|..  ..  ||        ...
yilrellltlllsagearevmhlhytdwpdhgvpqea..llellellld.....ggpvlvHCsaGkdRTGtvvallllllgvsletivddYlltnlylee

YLIAIRKHRPHMVQTKEQYSFIHSAVLEAlTCGNTEIQSEKYNQAMQKLA
..  .|..||..||| ||| |.. |.||.  .. .... | ...|.. . 
aveelraqrpgavqteeqylflyeallel.lrsllsvraeyllaaldaid
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 420-622 1e-47 157.6 In-house 21-219 (288) alignment 
Range on Protein: 420-622
Range on HMM: 21-219/288.0
TGYALEFQRLNSVTSReipvEEKSVGEKPQNLHKNRFSDIIALNSCRVMLHKEHADEESDYINAVFLHAHRGRNAFIATQHPLLETVEDFWRMVTDYDIG
||.  |.. | .. .     .....|....| .|||. .|....  || |.| .  ...||||| ... .......|||| || .||.|||..| .... 
tgfseeynsLaalekt....ksvtagrlavnakknRyrnilpyDekrvklkkleeeagaDYinasyidgekkkkkyiatqgPladtvndfWelvyenkts

TIVMLNNLHDQVAPESSEYWPDHGA-TKYGHIGISVLSKQKKGDVICVKPKVTRKKKTHEVRHLHHVSWTDKCIPKVSRSVLDLLDEVQTSQQQCgNVPV
|||||..| ..   .  ||||| .  ..||.. . ........|..  |  . .||.  |. .... .|.|. .|. .. .|.||. |....|.    |.
tivmltelveggktkCeeYWPdadkpknyGsvtvtlveskeledfvlrklllekkkteleitqyqylaWpdhgvPeskapllellrqvkvanqad.tgpi

LVQC
.|.|
ivhC
0036941 (Phosphotyrosine protein) phosphatases II 413-623 1.1e-47 158.2 In-house 6-215 (297) alignment 
Range on Protein: 413-623
Range on HMM: 6-215/297.0
VNGKFPMTGYALEFQRLnsvtSREIPVEEKSVGEKPQNLHKNRFSDIIALNSCRVMLhkehADEESDYINAVFLHAHRGRNAFIATQHPLLETVEDFWRM
..... ....  ||..|     . ..  ..||...|.||.|||..||......|| |     ||.|||||| ..  ..  ..|||||.|| .||||||||
lekllflalllkefeel....lpllllgslsvallpenleknRykdilpydhtRVkl....ddegsdYinAsyvdgydlkrkfIatqgPlpntvedFWrm

VTDYDIGTIVMLNNLHDQVAPESSEYWPDH--GATKYGHIGISVLSKQK--KGDVICVKPKVTR--KKKTHEVRHLHHVSWTDKCIPKVSRSVLDLLDEV
| .... .||||..| .   .   .|||.   .  .||.. . .|| ..  ..|..  . .||   ......|.|.|. .| | ..|   .|.||....|
vweqnvtvIvmltelvelgrekcaqywpleegesltygdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfielv

QTSQQQC-GNVPVLVQCR
.. ...  .. |||| |.
rkvlkllpsggpvlVHCs
DSPc_SM00195 425-623 3e-47 156.5 In-house 5-203 (263) alignment 
Range on Protein: 425-623
Range on HMM: 5-203/263.0
EFQRLNSVTSREipveEKSVGEKPQNLHKNRFSDIIALNSCRVMLHKEHADEESDYINAVFLHAHRGRNAFIATQHPLLETVEDFWRMVTDYDIGTIVML
||..|.. || .    |.. .||..| .|||...|.  .. || |.||. .|.|||||| ..  .. ....||||.|| .|||||||||.. .. .||||
efekleestspk....etteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivml

NNLHDQVAPESSEYWPDH--GATKYGHIGISVLSKQKKG-DVICVKPKVTRKK--KTHEVRHLHHVSWTDKCIPKVSRSVLDLLDEVQTSQQQCgNVPVL
..  ..   . ..|||.   | ...|.| . . ...||  ..|  . ..| ..  .|..|..... .|.|. .|.  .|||.|| .|..|...  ..|..
teeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkksksts.sgpiv

VQCR
|.| 
VhCs
PTPc_SM00194 425-623 3e-47 156.5 In-house 5-203 (263) alignment 
Range on Protein: 425-623
Range on HMM: 5-203/263.0
EFQRLNSVTSREipveEKSVGEKPQNLHKNRFSDIIALNSCRVMLHKEHADEESDYINAVFLHAHRGRNAFIATQHPLLETVEDFWRMVTDYDIGTIVML
||..|.. || .    |.. .||..| .|||...|.  .. || |.||. .|.|||||| ..  .. ....||||.|| .|||||||||.. .. .||||
efekleestspk....etteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivml

NNLHDQVAPESSEYWPDH--GATKYGHIGISVLSKQKKG-DVICVKPKVTRKK--KTHEVRHLHHVSWTDKCIPKVSRSVLDLLDEVQTSQQQCgNVPVL
..  ..   . ..|||.   | ...|.| . . ...||  ..|  . ..| ..  .|..|..... .|.|. .|.  .|||.|| .|..|...  ..|..
teeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkksksts.sgpiv

VQCR
|.| 
VhCs
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 421-622 5.3e-47 155.4 In-house 24-223 (319) alignment 
Range on Protein: 421-622
Range on HMM: 24-223/319.0
GYALEFQRLNSVTSReipveEKSVGEKPQNLHKNRFSDIIALNSCRVMLHKEHADEESDYINAVFLHAHRGRNAFIATQHPLLETVEDFWRMVTDYDIGT
. . ||. |.  ..      . .  .|..| .|||...|.| . .||.| . .  |.|||||| |. ... |..||||| || .|.||||||| .... .
llekefkllkeavnd.....tfdsaskeenkkknryqnilaydrtrvvlseldgvegsdyinasfidgyqerekfiatqaPlentiedfWrmvWeeessi

IVMLNNLHDQVAPESSEYWPDHGATKYGHIGISVLSKQKKGDVICVKPKVTRKKKT---HEVRHLHHVSWTDKCIPKVSRSVLDLLDEVQTSQQQCGNVP
.|||..| ...  . ..|||..  ..||.. . ....... |.|  | |. .|.      || | .. .|.|. .|. ..|.|||| ... |...  . |
vvmltklveklkvklkkywpeenfeeyGrlivtleeeeeledyiirklklnkkssevetRevkhfqyteWpdhdvPekatslldllkrirksrektqsgP

VLVQC
. | |
ivvhC
0039614 (Phosphotyrosine protein) phosphatases II 412-623 1.4e-46 154.7 In-house 24-230 (297) alignment 
Range on Protein: 412-623
Range on HMM: 24-230/297.0
SVNGKFPMTGYALEFQRLNSVTSreipvEeKSVGEKPQNLHKNRFSDIIALNSCRVMLHKEHA-DEESDYINAVFLHAHRG-RNAFIATQHPLLETVEDF
 .. .. .|.. |||..| |..      . .|....|.| .|||..||......|| |. |   |..|||||| ..  ..   ..|||||.|| ||||||
llekansktllllefeellslkp.....d.ysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfIatqgPlpetvedF

WRMVTDYDIGTIVMLNNLHDQVApESSEYWPDHGAtKYGHIGISVLSKQKKGDVICVKPKVTRKKKTHEVRHLHHVSWTDKCIPKVSRSVLDLLDEVQTS
|||| .... .||||..| .       .|||. |  .||.. . .|. .......  . .||.......|.|.....| | ..|  ....|..|..|.. 
wrmvweqgvtvivmLtklvelgr.kcaqywpeegg.tygdftvtllkvehldgytvrtlevtnngesrtvthfqytgwpdhgvppslellleflelvrea

QQQC-GNVPVLVQCR
.... .. |||| | 
laelpkggpvlVHCs
0045450 (Phosphotyrosine protein) phosphatases II 419-623 3.8e-46 153.6 In-house 26-242 (307) alignment 
Range on Protein: 419-623
Range on HMM: 26-242/307.0
MTGYALEFQRLNSVTSREipVEEKSVGEKPQNLHKNRFSDIIALNSCRVMLHKEHAD-EESDYINAVFL--------HAHRGRNAFIATQHPLLETVEDF
.||.. ||..|.||| .   . | |....|.| .|||..||......|| |. .. . |.|||||| .         . ..  ..|||||.|| ||||||
ltgllkefekllsvtvfl..lgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydlkrkfIatqgPlpetvedF

WRMVTDYDIGTIVMLNNLHDQVAPESSEYWPDHGAT-KYGHIGISVLSKQKKGDVICVKPKVT---RKKKTHEVRHLHHVSWTDKCIPKVSRSVLDLLDE
|||. ......||||..| .   .   .|||| | .  ||.. . .||......... . .||    ......|.|.|. .| | ..|.   ..||...|
wrmlweqgvtvivmltelvelgrekcaqywPdegeeltygnftvtllseehldgytvrtlevtdldgtgesrtvthfhytgwpdhgvppsfeelldfiee

VQTSQQQC-GNVPVLVQCR
|.. .... .. |||| |.
vrkaleelpkggpvlVHCs
subfamily_PTPRK_pd Subfamily PTPRK 443-623 2.3e-45 149.8 In-house 36-218 (314) alignment 
Range on Protein: 443-623
Range on HMM: 36-218/314.0
SVGEKPQNLHKNRFSDIIALNSCRVMLHKEHADEESDYINAVFLHAHRGRNAFIATQHPLLETVEDFWRMVTDYDIGTIVMLNNLHDQVAPESSEYWPDH
 .  | .| .|||. ||.| . .||.|.  . | .|||||| .. ...  .|||.||.|| |||.||||.| |..  .||||..| .. . . ..|||..
daakkdenreknrsgdilaydrsrvflitidgdpssdyinaalidsykrpaafivtqgPlqetvkdfWrlvydencasivmltelvevgrvkClkyWPed

GATkYGHIGISVLSKQKKGDVICVKPKVTR----KKKTHEVRHLHHVSWTDKCIPKVSRSVLDLLDEVQTSQQQcGNVPVLVQCR
. . ||.| . ... . . ...    .|..    .....|||......|.|  .|.  ...|.|. .|..||.. .. ...| | 
tev.ygdikvelvetellaelvvrifrveklargqeeirevrqfqflgWpdhdvPvsatgllklvrrvkksqee.eaGrivvhCs
subfamily_Ptp69D_pd Subfamily Ptp69D 421-624 4.7e-45 149.0 In-house 23-228 (307) alignment 
Range on Protein: 421-624
Range on HMM: 23-228/307.0
GYALEFQRLNSVtsrEIPvEEKSVGEKPQNLHKNRFSDIIALNSCRVMLHKEHADEESDYINAVFLHAHRGRNAFIATQHPLLETVEDFWRMVTDYDIGT
|.| |...|..    ||.  . .|.||  |. |||. ||.| .. ||.|.|   .|.|||||| |..... .. ||| | |. .|..|||||... .. .
glakeyekLear...eid.kstkvsekkenalknRyedikafDktRvkLkkingkedsdYinasfikgykekkkfiaaqdPveatigDfWRmiaeqevtl

IVMLNNLHDQVAPESSEYWPDHGATKYGHIGISVLSKQKKGDVICVKPKVTRKK-------KTHEVRHLHHVSWTDKCIPKVSRSVLDLLDEVQTSQQQC
|||| || ..   . . |||.   ..||.| . . |..|..| |  . .|..||       ....|   |. .| |  .|.|.|..|.|...|.  ... 
ivmlsnlteknrkkcakYWpiedevqygdilvklvseekhsdyiiReldvskkkeesgevedsrkvvqyhytgWkDskvPevargllklieqvrelykln

gNVPVLVQCRY
 . |..| |. 
.rsPivvhCsa
subfamily_PTPRA_pd Subfamily PTPRA 443-622 6.8e-45 148.4 In-house 51-235 (330) alignment 
Range on Protein: 443-622
Range on HMM: 51-235/330.0
SVGEKPQNLHKNRFSDIIALNSCRVMLHKEHADEESDYINAVFLHAHRGRNAFIATQHPLLETVEDFWRMVTDYDIGTIVMLNNLHDQVAPESSEYWPDH
 . .| .| .|||. .|.  .  ||.| . .  |||||||| |.. .. .. |||.| |. |||||||||. ...  ||||| .|...       ||||.
elaskeenkeknrvvnilPydfsrvilsvkeGveesdyinasfidGykekdkfiaaqGPkeetvedfwrmiweqksativmltelkerkeekcaqywPde

GATKYGHIGISVLSKQKKGDV----ICVK--PKVTRKKKTHEVRHLHHVSWTDKCIPKVSRSVLDLLDEVQTSQQQCGNvPVLVQC
|.  ||.| ..|  ..   |.    ..|.  |. ||.||.  || .|  || |  .|  .. .|.|| .|.. .|| .. |. | |
GlvtyGnirvevedetvlvdytvrkflvqqlpdatrekksrlvrqfhftswPdvGvPfepiGmlkllkkvkklnqqsag.pivvhc
subfamily_PTPRB_pd Subfamily PTPRB 397-622 8.5e-45 148.0 In-house 6-225 (293) alignment 
Range on Protein: 397-622
Range on HMM: 6-225/293.0
EIQSEKYNQAMQKLASVNGkfpmTGYALEFQRLNSVTSREipveEKSVGEKPQNLHKNRFSDIIALNSCRVMLHKEHADEESDYINAVFLHAHRGRNAFI
.|. ||... ..|... .     .... |...|..| . .    .... |...|  |||...|.. .  || |.. . ...|||||| ... .. .. ||
piklekfeehvkkmkadsd....lrfseeyeelkavgkdq....avkaaelavnraknrytnilpydhsrvkLaalkdesgsDYinanyipgynsprefi

ATQHPLLETVEDFWRMVTDYDIGTIVMLNNLHDQVAPESSEYWPDH-GATKYGHIGISVLSKQKKGDVICVKPKVTRKKKTHEVRHLHHVSWTDKCIPKV
||| || |||.|||||| .    .|||| .| ..      ||||..  .. ||.| ......... | .. . |....|....||..|..||.|  .|. 
atqGPlpetvddfWrmvwekkssiivmltqlvekgkvkCeeYWPadeepvlyGdikvtlvaeeeledwvirelkiekekeerkvrqyhftsWpdhgvPek

SRSVLDLLDEVQTSQ-QQCGNVPVLVQC
....||.. .|.... ... . |..| |
tktlldfvrtvreaiektaskrPivvhC
0043336 (Phosphotyrosine protein) phosphatases II 414-623 1.1e-44 148.4 In-house 14-218 (278) alignment 
Range on Protein: 414-623
Range on HMM: 14-218/278.0
NGKFPMTGYALEFQRLNSVTSreipvEEKSVGEKPQNLHKNRFSDIIALNSCRVMLHKEHADEESDYINAVFLHAHRGRNAFIATQHPLLETVEDFWRMV
 ..   |.. |||..|.|..      ...|....|.| .|||..||......|| |. .  |. |||||| ..  ..  ..|||||.|| ||||||||||
lllnlktllllefeellsfkl.....dtysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyvdgynvprkfiatqgPlpetvedFwrmv

TDYDIGTIVMLNNLHDQVAPESSEYWPdHGATKYGHIGISVLSKQKKGDVICVKPKVT--RKKKTHEVRHLHHVSWTDKCIPKVSRSVLDLLDEVQTSQQ
 .... |||||..| .   . . .|||  | ..||.. . .|. ....|..  . .||  .......|.|.|...| | ..|    ..||.| .|.. ..
welgvttivmLtelvelgrvkcaqYwp.ggsltygdftvtllkeehlddytvrtlevtnlgdgesrtvthyhylgwpdhgvpeslsllldflkavreale

qCGNVPVLVQCR
   | |||| |.
.dsngpvlVHCs
subfamily_PTPN12_pd Subfamily PTPN12 421-622 5.3e-44 145.2 In-house 9-214 (290) alignment 
Range on Protein: 421-622
Range on HMM: 9-214/290.0
GYALEFQRLNSVTSREI--PVEEKSVGEKPQNLHKNRFSDIIALNSCRVMLHKEHADEESDYINAVFLHAHRGRNAFIATQHPLLETVEDFWRMVTDYDI
 .| |||.| .....     | ....|||..| .|||. ||.  .  ||.|.|.. .|.|||||| |..   |. ..||.| || .|..|||||. ....
efakefqklkklsekykaekvysteagekeenvkknrykDilPydksrvelskieeeegsdYinanfikgvegkleyiaaqgPLpktlddfWrmiweknv

GTIVMLNNLHDQVAPESSEYWPDHGAT--KYGHIGISVLSKQKKG-DVICVKPKVTRKKKTHEVRHLHHVSWTDKCIPKVSRSVLDLLDEVQTSQQqCGN
  .||. .. .        |||..| .  ..|.. ... ....   | .    ||...|....|. .|. .| |. .|.   |.|.|...|.. |.   .
eivvmaCrevelgkkkCerYWpeegeeelefgefevtleeekavdddflirtLkveaqkesrkvyqfhYtaWPDhgvPssaksllelielvrelqe.sed

VPVLVQC
.|..| |
aPlvvhC
Y_phosphatase Protein-tyrosine phosphatase 450-623 1.3e-43 144.5 Pfam-A 1-178 (235) alignment 
Range on Protein: 450-623
Range on HMM: 1-178/235.0
NLHKNRFSDIIALNSCRVMLhkEHADEESDYINAVFLHAHRGRNAFIATQHPLLETVEDFWRMVTDYDIGTIVMLNNLHDQVAPESSEYWP--DHGATKY
|..|||..||.. .. || |  .. ...|||||| ... ..  ..|||||.|| .|.|||||||..... .||||..| ..   . ..|||  ... ..|
nkkknRykdilpydktrvkl..kgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeeslty

GHIGISVL-SKQ-KKGDVICVKPKVTRKKKT---HEVRHLHHVSWTDKCIPKVSRSVLDLLDEVQTSQqQCGNVPVLVQCR
|.| . .  ... .. ...  | ... ||.    .||..||. .|.|...|. ..|.|||...|..|. .  . ||.|.| 
gdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkveksk.eaksgpvvVhCs
Y_phosphatase Protein-tyrosine phosphatase 450-623 1.3e-43 144.5 In-house 1-178 (235) alignment 
Range on Protein: 450-623
Range on HMM: 1-178/235.0
NLHKNRFSDIIALNSCRVMLhkEHADEESDYINAVFLHAHRGRNAFIATQHPLLETVEDFWRMVTDYDIGTIVMLNNLHDQVAPESSEYWP--DHGATKY
|..|||..||.. .. || |  .. ...|||||| ... ..  ..|||||.|| .|.|||||||..... .||||..| ..   . ..|||  ... ..|
nkkknRykdilpydktrvkl..kgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeeslty

GHIGISVL-SKQ-KKGDVICVKPKVTRKKKT---HEVRHLHHVSWTDKCIPKVSRSVLDLLDEVQTSQqQCGNVPVLVQCR
|.| . .  ... .. ...  | ... ||.    .||..||. .|.|...|. ..|.|||...|..|. .  . ||.|.| 
gdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkveksk.eaksgpvvVhCs
0036282 (Phosphotyrosine protein) phosphatases II 187-384 2.1e-43 143.3 In-house 3-163 (174) alignment 
Range on Protein: 187-384
Range on HMM: 3-163/174.0
DYINASFIHGYDGTPrSFIASQGPLPpafegFWRMVWEQNSQSIVMLTNLVGLNKTKCHKYWPDktetyggvtvtlhqsevfagyenctfilskEKRSGS
||||||.....  ||  .||.||||.     ||.|..|......|||.... |...||. |||.                               . . .
dyinaspldlsyitp.rliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe..............................lredle

RIVRQFHFTVWPDKGVPQYATaVLAFRRKVRALNPR-DAGPVIVHCSVGVERTGAYIVIDAMLEQAKkSRTVDIRNYLIAIRKHRPHMVQTKEQYSFIH
| . |.... ||| |||  .. .| | . |.    . . |||.|||| || |||. .... || . . ...||. ... ..|..||.|||| .|| |..
rlgiqylylpwpDhgvpdlsi.llefvkfveealsedpggpvlVHCsaGvgRtGtlvaaylmlrgll.eslvdaldlvrelRlqrpgmvqtpsQyrfly
0042113 (Phosphotyrosine protein) phosphatases II 443-623 5.8e-43 142.4 In-house 2-184 (245) alignment 
Range on Protein: 443-623
Range on HMM: 2-184/245.0
SVGEKPQNLHKNRFSDIIALNSCRVMLHKEHADEESDYINAVFLHAHRGRNAFIATQHPLLETVEDFWRMVTDYDIGTIVMLNNLHDQVAPESSEYWPDH
||...| | .|||.|||......|| |  .  |. |||||| . . .|  . |||||.|| |||||||||. ...| |||||.....   . . .|||..
svallpenkdknrysdilpydhtrvklspdggdldsdyinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywplg

GATKYGHIGISVLSKQKKGDVICVKPKVT--RKKKTHEVRHLHHVSWTDKCIPKVSRSVLDLLDEVQTSQQQCGNVPVLVQCR
. ..||.. . .|| ....|... . .||  ......||.|.|...| | ..|  ....||.|..|.. .....| |||| |.
esltygdftvtllseehlddytvrtlevtnlgddesrevihyhylpwpdhgvpdllellldflefvrkalaedsngpvlVHCs
0040439 (Phosphotyrosine protein) phosphatases II 442-623 2e-42 140.9 In-house 3-187 (249) alignment 
Range on Protein: 442-623
Range on HMM: 3-187/249.0
KSVGEKPQNLHKNRFSDIIALNSCRVMLHKEHADEESDYINAVFLHAHRGRNAFIATQHPLLETVEDFWRMVTDYDIGTIVMLNNLHDQVAPESSEYWPD
.||...| |..|||..||......|| |.     . |||||| ...  .  ..|||||.|| |||||||||. ...|..||||..|         .|||.
ysvallpenkdknrypdilpydhsrvklsilpglflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywpl

HGATKYGHIGISVLSKQKKGDVICVKPKVT--RKKKTHEVRHLHHVSWTDKCIPKVSRSVLDLLDEVQTSQQQC-GNVPVLVQCR
 | ..||.. . .|| ..|.|... . ..|   ......|.|.....| |  .|.   ..||....|.. ....  . |||| | 
ggsleygdftvtllsvevkddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCs
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 418-622 1.2e-41 137.6 In-house 13-215 (281) alignment 
Range on Protein: 418-622
Range on HMM: 13-215/281.0
PMTGYALEFQRLNSVTSREIPVeeksVGEKPQNLHKNRFSDIIALNSCRVMLHKEHADEESDYINAVFLHAHRGRNAFIATQHPLLETVEDFWRMVTDYD
  .|.. |.. |...  ..  .      ....| .|||.|.|.| .  || ..........||||| |. . .| ...|||| |. .....||.|| ...
dnaGfieeyeklaaigvdntat....askadenvlknrYsnivaYDatrvkvtpneenkntDYinanfvpgykgekeyiatqgPvPaslvafWqmvweqk

IGTIVMLNNLHDQVAPESSEYWPDHG-ATKYGHIGISVLSKQKKGDVICVKPKV-TRKKKTHEVRHLHHVSWTDKCIPKVSRSVLDLLDEVQTSQQQCGN
. .|||. .  ..       ||||.  ..|||.. .. .....|   |. | |. ... .| ||..|....| |. .|. .. .|.  .||.  ...  .
vsaivmvtreieagklkChrYWPddnselkygdvtvkstaeeekatyierkfkleresgetreveqlaytaWPdhGvPattkellefrkevlkltekktk

VPVLVQC
.|... |
aplvihC
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 440-622 7.8e-41 135.2 In-house 36-223 (305) alignment 
Range on Protein: 440-622
Range on HMM: 36-223/305.0
EEKSVGEKPQNLHKNRFSDIIALNSCRVMLHKEHADEESDYINAVFLHAHRGRNAFIATQHPLLETVEDFWRMVTDYDIGTIVMLNNLHDQVAPESSEYW
|   ||.| .| .|||...|. |.  |..| ... ...|||||| ...........|..| || .||.||||.. .. . ||||| .| ..       ||
esidvgkkeankaknrlkeitlldddriiltekeslddsdyinasyvdgykrkkkyivaqgPlkntvadfWrliveekvstivmltklveggkdkCrqYW

PDHGAT--KYGHIGISVLSKQKKGDVICVKPKVTR---KKKTHEVRHLHHVSWTDKCIPKVSRSVLDLLDEVQTSQQQCGNVPVLVQC
|.  .   ..|.. . . |...  | |  | |..    .|... | ...  .| |. .|. . |.|.|...|| .|..  .||.|| |
pesktekkefgefsvelksektasdyieRklkisiededkesrtvlqyqltdWPdhGvpqfatsllslikrvqkdqkkdkgvpllVhC
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 145-391 1.2e-40 134.5 In-house 28-277 (307) alignment 
Range on Protein: 145-391
Range on HMM: 28-277/307.0
QFPWGAARKPANKNKNKNRYANIVAYDHSRVVLErVNGDeDLDYINASFIhGYDGTPRSFIASQGPLPPAFEGFWRMVWEQNSQSIVMLTNLVGLNKTKC
. | | . .  . | .|||| .. . |..|.|.. ..|    ||| | .. |    |. ||..||||  .   || |. ... .|..|| ... | | ||
ktpegvtveafsantdknryqdvkcqdkgrivvk.fdgl.asdyihanyl.giaikpkkficaqgplentqysfwamaiqekvesvimlckvielakikc

HKYWPD---KTETYGGVTVTL----HQSEVFAGYENCTFIL--SKEKRSGSRIVRQFHFTVWPDKGVPQYATAVLAFrrkVRALNpRDAGPVIVHCSVGV
..|||    .. ..|  . |.      .. .|  |..  .     .  ..|| .... .. |||.||||   . . .   . | .  |  ||.|||| ||
eqywpleegqklvfgeapntisvanlgakklapdedlinvttlkvdwaqksrtiqhlqwenwpdrgvpqinltainl...leavr.ydtnpvvvhcsaGv

ERTGAYIVIDAMLEQAKKS-RTVDIRNYLIAIRKHRPHMVQTKEQYSFIHSAVLEAL
 |.|. . |  . ..  .     |... .  .|..|.. .||. || ..|  .|| .
GrsGtivaislvqdkmiaGinckdmkklveelrsqrhyaiqteaqylylhrvlleyf
0045098 (Phosphotyrosine protein) phosphatases II 438-623 2.1e-40 134.3 In-house 21-214 (278) alignment 
Range on Protein: 438-623
Range on HMM: 21-214/278.0
PVEEKSVGEKPQNLHKNRFSDIIALNSCRVMlhkehadeesDYINAVFLHAHrgRNAFIATQHPLLETVEDFWRMVTDYDIGTIVMLNNLHDQVAPESSE
.. | ... .. ||.|||..||......||           ||||| ... .  ...|||||.|| .||.|||||. ...| .||||..|..       .
ipseitpalylgnldknRykdilpydhsrVk..........dYINAsyidgy..pkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrekcaq

YWPDHGATKYGHIGISVLSKQKKGDVICVKPKVT------RKKKTHEVRHLHHVSWTDKCIPKVS--RSVLDLLDEVQTSQQ------------QCGNVP
|||..|   ||.. . .|| .  .|.. .. .||         ....|.||| ..| | ..|  .  .|.|.||....  ..            . .. |
ywpeggsltygdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsggp

VLVQCR
||| |.
vlVHCs
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 155-389 3.8e-40 132.4 In-house 51-281 (290) alignment 
Range on Protein: 155-389
Range on HMM: 51-281/290.0
A--NKNKNKNRYANIVAYDHSRVVLErvNGdEDLDYINASFIHGydgTPRSFIASQGPLPPAFEGFWRMVWEQNSQSIVMLTNLVGLNKTKCHKYWPDKT
   | . .|||| ..|  | .||.|.  .|  | ||. | ...|   .   || .||.|  .   .|||| ...   |||| .|.   |.||..|.|.| 
fdkntefkknrykdvvcndktrvilk..dG.ydGdyvhanyvkG...lkamfiltqGalkdtvidiwrmvlqekvaaivmlceliedGkakceqyypeke

---ETYGGVTVTLHQSEVFAGYENCTFILSKEKRSG-SRIVRQFHFTVWPDKGVPQYATAVLAFRRKVRALnprdAGPVIVHCSVGVERTGAYIVIDAML
    |.| .||.  ...          .  ..| || . ... ..   |||| |.. . |.|   | .| .    .|||.|||| |. |||... |.. |
GevltfGeitvlcseeddkdaniikktlsvrdkdsGkehklkhlkikswpdksvalstlallrtlrilrka....sGpvvvhcsaGiGrtGtfvaievgl

EQAKKSRTVDIRNYLIAIRKHRPHMVQTKEQYSFIHSAVLE
.   . . .|. .   |.|. |   ||   ||  .  ..|.
qilldGkeldlldlvralrnsrlnsvqvdiqylalveilld
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 439-623 3.9e-40 132.8 In-house 40-225 (297) alignment 
Range on Protein: 439-623
Range on HMM: 40-225/297.0
VEEKSVGEKPQNLHKNRFSDIIALNSCRVMLHKEHADEESDYINAVFLHAHRGrnAFIATQHPLLETVEDFWRMVTDYDIGTIVMLNNLHDQVApESSEY
. .. | ||  |..|.|...|.  .| ||.|.    | .|||.|| |... .    .|.|| |  .||.|||.|| |... ||||||.....   .   |
iqpqtvaekkvnfeksRYkniLPydssRvkLaivnddpdsDyvnasfvkgnkh..rlittqmPmkatvadfWamvldeqvstivmlnddnerdk.kcary

WPDHGATKYGHIGISVLSKQKKGDVICVKPKVTRKK--KTHEVRHLHHVSWTDKCIPK--VSRSVLDLLDEVQTSQQQCGNVPVLVQCR
|.|.| |..|.. . .|| ...   |  . .||. |  ... |.  ..|.| || ...    .|.|.|..||. . .|  . |.|| | 
WsdkgvttfGdvsvvllsvsereGfikrelevtkgkakarrvvkqyqfveWPdkaverkdsassllklisevrkdfsqnaegPllvhcl
0046846 (Phosphotyrosine protein) phosphatases II 180-389 9.3e-40 131.6 In-house 6-171 (176) alignment 
Range on Protein: 180-389
Range on HMM: 6-171/176.0
VNGDEDLDYINASFIHGYDgtprsFIASQGPLPPAFEGFWRMVWEQNSQSIVMLTNLVGLNKTKCHKYWPDKTETYGgvtvtlhqsevfagyenctfils
   |.|||||||..| |.      .|| |||||  .. |..|..|.. . .|.||..| |.. ||. |||. ..                          
lgldldldyinanlilgsr.....piatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgi.......................

kekrsgsrivrQFHFTVWPDKGVPQYaTAVLAFRRKVRALNPRDaGPVIVHCSVGVERTGAYIVIDAMLEqakkSRTVDIRNYLIAIRKHRP-HMVQTKE
           |.... ||| |||.. ...| . . .|    .. |||.|||| |. |||...... .      .. ... . |  .|..|| ..||| |
...........qylhlpwpDhgvpdl.elllellefirealkeg.gpvlVHCsaGigRtgtlvaayllel....ekglsveealalvreqRplgavqtpe

QYSFIHSAVLE
|| |.. ..|.
Qyrflyefell
subfamily_PTPRG_pd Subfamily PTPRG 420-624 9.4e-40 131.3 In-house 19-229 (563) alignment 
Range on Protein: 420-624
Range on HMM: 19-229/563.0
TGYALEFQRL-NSVTSREIPVEEksvGEKPQNLHKNRFSDIIALNSCRVMLHKEHADEES-DYINAVFLHAHRGRNAFIATQHPLLETVEDFWRMVTDYD
.|.. ||. | . ..|.....|     .||.| .||| ..|.| .. || |..    ... ||||| ... ..  .||||||.|| .|..|||||. .  
igfseefealqsetiskdldaeh...sqkpenkrKnRylnivaydrsRvklsplpgkkkklDYinAnyidGyqkskafiatqgplkdtfddFWrmiWeqn

IGTIVMLNNLHDQVAPESSEYWPDHGATKYGHIGISVLSKQKKG----DVICVKP-KVTRKKK---THEVRHLHHVSWTDKCIPKVSRSVLDLLDEVQTS
  .|||. || .. . .   |||  .. .||.. .   .....       . .|  |. .||.    ..||. |  .| |.. |. |  ||      ...
vaiivmitnlvergrrkcdvYWPkdesetygalqvtlieeevlalytvrtlviknlklkkkkqcdteklvrqyhytkWPdhgvPehslpvLifvkkssaa

QQQ-CGnvPVLVQCRY
...  |  |..| |..
nkaeaG..PivvHcsa
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 444-623 1.1e-39 131.2 In-house 43-220 (315) alignment 
Range on Protein: 444-623
Range on HMM: 43-220/315.0
VGEKPQNLHKNRFSDIIALNSCRVMLHKEHADEESDYINAVFLHAHRGRNAFIATQHPLLETVEDFWRMVTDYDIGTIVMLNNLHDQVAPESSEYWPDHg
|  | .| .|||. .||| .  || |     |..|||.|| |.  .  .. .||.| |. ..|.||||.| ..|||.||||.|| ..    . .||||. 
vakkienkqknryiniiaydksrvqlpllendphsdyvnanfidGynkkrryiaaqgpnvasvkdfwrlvfeedigkivmltnlvegekrkaekywpdk.

ATKYGHIGISVLSKQKKGDVICVKPKVTRKKKTHEVRHLHHVSWTDKCIPKVSRSVLDLLDEVQTSQQQCGnVPVLVQCR
   ||.| ..  |.... .. .    |. ... .||  ||. || |  .|| . ....|   |.  ...    ...| |.
kviyGkitvtrkseevnteytvrtlsvvfgdnirevvqlhytswpdmgvpkytiplmnlirtvkqhhtnsv.gaivvhcs
0049772 (Phosphotyrosine protein) phosphatases II 157-392 6.1e-39 130.0 In-house 45-281 (314) alignment 
Range on Protein: 157-392
Range on HMM: 45-281/314.0
KNKNKNRYANIVAYDhSRVVLERVNGDeDLDYINASFIHGYdgtpRSFIASQGPLPPAFEGF----------WRMV--WEQNSQSIVM------------
.|..|||| .|. .| .||.| ..... . ||||||...|.    ..|||.||||.  .. |          ||||  ...|.  |||            
lnrdknryldilpad.nrvilpglpvs.gsdyinasyvdgf....lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivmsrdevladelsr

---------LTNLVGLNKTKCHKYWPDKTetyggvtvtlhqsevfagyenctfilSKE--KRSGSRIVRQFHFTVWPDKGVPqYATAVLAFRRKVRALnp
         |..| |..   . .....                            .    .   .| . ... . .|| ..|     ...| . ....  
LdaAlgKtpllildgngneptaadlellk..........................eelydpelferlgikylripvpDgsap.lledfdeflefieea..

RDAGPVIVHCSVGVERTGAYIVIDAMLEQAKksrtVDIRNYLIAIRKHRP-----HMVQTKEQYSFIHSAVLEALT
.. |||.|||. |. ||| ..|.. .. . .    |...  |  .|. ||     ..... ||| ||. |.||.| 
dkggpvlvHCkaGkgRtgtfvvaaylmkllg....vsleealedvrlkRpinpnpgfieqleqyefilealleylk
0043147 (Phosphotyrosine protein) phosphatases II 183-384 9.4e-39 128.2 In-house 2-154 (172) alignment 
Range on Protein: 183-384
Range on HMM: 2-154/172.0
DEDLDYINASFIHGYDGTPRsFIASQGPLPPAFEGFWRMVWEQNSQSIVMLTNLvglnktkchkywpdktetyggvtvtlhqsevfagyenctfilSKEK
||. ||||||....|  ..| ||| ||||.  .. ||||..|.. . ||.||.|                                           . .
degsdyinasyldlyyipdr.fiatqgplrntladfwrmlkelgithivnltel..........................................lydp

RSGSRIVRQFHFTVWPDKGVPqYATAVLAFRRKVRA-LNPRDAGPVIVHCSVGVERTGAYIVIDAMLeqakksRTVDIRNYLIAIRKHRPHMVQTKEQYS
   .| . |.... ||| |||  .  .| | . ..  |. .. |||.|||| || |||. .... ||      . ... . .  .|..||..||...|| 
ellerlgiqylylpwpDhgvp.llellleflefidellalspggpvlVHCsaGvgRtgtlvaaylml......lglsleeavalvrekRpgavqnpsqyr

FIH
|..
fly
0037934 (Phosphotyrosine protein) phosphatases II 444-624 2.8e-38 127.3 In-house 4-187 (243) alignment 
Range on Protein: 444-624
Range on HMM: 4-187/243.0
VGEKPQNLHKNRFSDIIALNSCRVMLhkehadEESDYINAVFLHAHrGRnaFIATQHPLLETVED----FWRMVTDYDIGTIVMLNNLHDQVAPESSEYW
.. .|.||.|||.|||....  || |      | |||||| .     .|  .||||.|| |||||    ||||. ...|..||||..| .  .    .||
iallpenlsknrysdilpydhsrvkl......egsdyinanliyvt.pr..liatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqyw

PdhGATKYGHIGISVLSKQKKGDVICVKPKVTR---KKKTHEVRHLHHVSWTDKCIPKVSRSVLDLLDEVQTSQQQ-------CGNVPVLVQCRY
|  | . ||.. . .|| . ..|..  . ....   .. |..|.|.|...| | ..|    ..||.||||.. ...        .. |||| |. 
p..gevtygdftvtllseehlddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsa
subfamily_PTPN9_pd Subfamily PTPN9 443-612 5.1e-38 125.8 In-house 35-208 (297) alignment 
Range on Protein: 443-612
Range on HMM: 35-208/297.0
SVGEKPQNLHKNRFSDIIALNSCRVMLHKEHADEESDYINAVFLHAHRGRNAFIATQHPLLETVEDFWRMVTDYDIGTIVMLNNLHDQVAPESSEYWP--
 . ... ||.|||..|.. ... ||.| |.. ||.|||||| |.  .. ..|||||| || .||.|||||| . .. .|||   . ..     ..|||  
lasklranleknrytdvlcydetrvvlakvdedeasdyinanfvdGykqkkafiatqGplkktvsdfWrmvWeqevlvivmttrvvergrlkcgqyWple

DHGATKYGHIGISVLSKQKKGDVICVKPKVT--RKKKTHEVRHLHHVSWTDKCIPKVSRSVLDLLDEVQTSQQQ
.. ....|.. .|... ... |    . ...  ..... .| |   .|| |  .|. . |.||.|..|.  | .
eessaefgdlsvsnveveeeedykvrvleiknvkteesrkvthfqflsWPdyGvPssaaslldvlekvrekqal
subfamily_PTPN6_pd Subfamily PTPN6 396-622 6.4e-38 125.5 In-house 2-234 (306) alignment 
Range on Protein: 396-622
Range on HMM: 2-234/306.0
TEIQSEKYNQAMQKLASVNGKFPMTGYALEFQRLNSVTSREipVEEKSVGEKPQNLHKNRFSDIIALNSCRVMLHkEHADEESDYINAVFLH--AHRGRN
|.. ... .| ...|   . ..  .|.  ||..|.   ...  . ... |.||.| .|||.  |.  .  ||.|. |.   .|||||| ...  ..  ..
tsllakeieqrvselekeeeslekagfeeefeelqqeeakk..llsrkegakpenkeknryknilPfDhtrvilk.epsvpgsdyinanyikkevkgsdk

AFIATQHPLLETVEDFWRMVTDYDIGTIVMLNNLHDQVAPESSEYWPDHGAT-KYGHIGISVLSKQKKGDVICVKPKVT---RKKKTHEVRHLHHVSWTD
..||||  | .||.|||||| . .   |||. .  ..     . ||||. .. .||.| .. .|.... | |  . .|.   .||...||...|. || |
syiatqgclettvsdFWrmvwqensrvivmttkevErgkekCarYWPdeeekeeyGkisvtnvseksladYilRelsvskkkkkkeerevfqyhfksWPd

KCIPKVSRSVLDLLDEVQTSQQQCG---NVPVLVQC
. .||    |||.|..|.. |...    . |..| |
hgvpkdpgavLdfledvnrkqeeleeaeagpivvhC
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 443-623 1.2e-37 124.2 In-house 36-217 (515) alignment 
Range on Protein: 443-623
Range on HMM: 36-217/515.0
SVGEKPQNLHKNRFSDIIALNSCRVMLHKEHADEESDYINAVFLHAHRGRNAFIATQHPLLETVEDFWRMVTDYDIGTIVMLNNLHDQVAPESSEYWPD-
.| ..  | .|||. .|. ..| || |   . . .|||.|| ....    .|.||.| |.  .|.||||.| .... ||.|...|...     ..|||| 
tvaqeeinfkknryknilPydsvrvklevindnPhsdyfnasyipsfdndkayiasqgPnkasvddfWrlvlqenvttiamvtklkegdkikcgkyWPdk

-HGATKYGHIGISVLSKQKKGDVICVKPKVTRKKKTHEVRHLHHVSWTDKCIPKVSRSVLDLLDEVQTSQQQCGnVPVLVQCR
   . |.|.| ....| .  .. |  | .|.. .... |   |   | || .|| ..|.| |. ||.....|    |... | 
pgdsvkfGsikvelvsleactggikrkltvlkgddsrtvtqfhfteWPdkGvpkhtssllklikevkadhgqyt.hpliihcs
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 154-389 1.7e-37 123.9 In-house 29-257 (267) alignment 
Range on Protein: 154-389
Range on HMM: 29-257/267.0
PANKNKNKNRYANIVAYDHSRVVLERVNGDedldYINASFIHGYDgTPRSFIASQGPLPPAFEGFWRMVWEQNSQSIVMLTNlVGLNktKCHKYWPDK--
 |.||...||. . . ||..||.|   . .    |||||...||  | . ||. |.||  .   |. .. .|.   ||.||. |. .  . ...|| |  
iaeknqernrlddnlpyddtrvilrtkeee....yinasyvegyk.tknafivtqdplkntitdfltvihdqkvpvivlltk.vftd..nirlfwPPkmg

-TETYGGVTVTLHQSEVFAGYENCTFILSKeKRSGSRIVRQFHFTVWPDKG-VPQYATAVLAFRRKVRALNprDAGPVIVHCSVGVERTGAYIVIDAMLE
 .. |  .||     .    |.  |. |   |   .. |  ...  |  .     |   ...   | .  |     |..|.|| || |.|...|||..||
qakkyqdltvehslekeendyqiitlelkf.knesahnvtlyyykkwnintnnkpylkplfgilaknqlen..gnrPlvvacsdGvGrsGtflvidsqle

QAKKSRTVDIRNYLIAIRKHRPHMVQTKEQYSFIHSAVLE
.||.  ..|| ..|  ||. |. .|.|||.| .||  . |
raktegvsdifdflrkirsqriglvdtkeryiyihellae
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 438-623 2.7e-37 123.3 In-house 32-218 (315) alignment 
Range on Protein: 438-623
Range on HMM: 32-218/315.0
PVEEKSVGEKPQNLHKNRFSDIIALNSCRVMLHKEHADEESDYINAVFLHAHRGRNAFIATQHPLLETVEDFWRMVTDYDIGTIVMLNNLHDQVAPESSE
.. .. |. ...| .|||. .|. |.| ||.|     . .|||||| ....    .|.||.| ||  .|.|||||| .... ||||.......   .   
diyrqrvaretinfkknryknilPldsarvkleviddsPdsdyinasyiksvdddkayiasqgPlkasvddfwrmvlqekvttivmvtkkqegdkikcrq

YWPD--HGATKYGHIGISVLSKQKKGDVICVKPkVTRK-KKTHEVRHLHHVSWTDKCIPKVSRSVLDLLDEVQTSqQQCGNVPVLVQCR
||||    ....| | ...|| .  .| .  |  |||| .... |   .   | || ..| . |.| |. ||... ..  . ..|| | 
ywPdrkadsvefGsikvellsleadtdgvarkl.vtrkseesrtvtqfqftewPdkGvdkqtssllklikevkad.ngkkefsllvhcs
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 421-622 5.5e-37 122.6 In-house 24-228 (325) alignment 
Range on Protein: 421-622
Range on HMM: 24-228/325.0
GYALEFQRLNSVTSReipveEKSVGEKPQNLHKNRFSDIIALNSCRVMLHKEHADEESDYINAVFLHAHRGRNAFIATQHPLLETVEDFWRMVTDYDIGT
|.| ||. | |. .       | |  ||.|  |||| ...||.  ||.|   . | .|||||| .|. ..... |.|.| || .|..|.||.| |.    
gfahefgllpsddgi.....akkvamkpenkaknrfknvvaldksrvvletkkddpssdyinasylrddkkkdvflaaqaPltatindlWrlvldWrcsv

IVMLNNLHDQvAPESSEYWPDH--GATKYGHIGISVLSKQKKGDVICVKPKVTRKKK--THEVRHLHHVSWTDKCIPKVSRSVLDLLDEVQTSQQQ----
.|.|| |  .   . . |||..   . ..| . ... . ..  | .  . .| . ||  |  |. ... || |   .|   ... .|. |.. ...    
vvvlneldlg.kdrcavywpkemgksktfGglevklrtieeisdyvhrvldvkqvkkGetrsvkqfqlqswddmGvqkrpatlisilqlvkavservtan

-CGNVPVLVQC
  .  |.|| |
tkastpilvhc
0049260 (Phosphotyrosine protein) phosphatases II 201-384 6.9e-37 121.8 In-house 8-143 (152) alignment 
Range on Protein: 201-384
Range on HMM: 8-143/152.0
PRSFIASQGPLPPAFEGFWRMVWEQNSQSIVMLTNLVGLNKTKCHKYWpdktetyggvtvtlhqsevfagyenctfilskekrsgsrivrQFHFTVWPDK
|. ||| |||.|  .. ||||..|.. . |||||.|. |.| ||..|.                                          |.... ||| 
pfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi..........................................qylhlpwpDh

GVPQYATAVLAFRRKVRALNPRDAGPVIVHCSVGVERTGAYIVIDAMLeqakksRTVDIRNYLIAIRKHRPHMVQTKEQYSFIH
|||. .  .| . . .. |. .. |||.|||| || |||...... ||      . |.. ...  .|..||..|....|. |..
gvpdlsqlllflllfieklaldkggpvlVHCsaGvgRtgtlvaaylml......lgvsleeavalvrekRpgavpnpgqlrfly
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 419-622 2.2e-36 120.3 In-house 19-218 (287) alignment 
Range on Protein: 419-622
Range on HMM: 19-218/287.0
MTGYALEFQRLNSVTSREipvEEKSVGEKPQNLHKNRFSDIIALNSCRVMLHkehaDEESDYINAVFLHAHRGRNAFIATQHPLLETVEDFWRMVTDYDI
 .|.   |. |..|| ||   .|  ..  .|| .|||...|.  .  ||.|.    .|. |||||||. ... ..|||... |. .|. .||... |  .
negfknqftvleqvtqre...devthniasqnkdknRltqilvpdnyrvllk....gehpdyinavfidgykekkafiiaesPmfntarnfWkliddrnv

GTIVMLNNLHDQVAPESSEYWPDHGATKYGHIGISVLSKQKKGDVICVKPKVTRKKK---THEVRHLHHVSWTDKC-IPKVSrSVLDLLDEVQTSQQQCG
 .|||| .....      .|||.. .. .|.  |..|..... ..|  | .|..|.|   ...|.  .  .| ..  ...   ..| ...|   .|.. |
taivmlcqekendeevcyqyWpeeksvvlGeyniellneevnagyierklevknknkagdkqqvkqyqitnWdstgkvtepq.tillvieemyktqrkrg

NVPVLVQC
| ...| |
ntsivvhC
0044763 (Phosphotyrosine protein) phosphatases II 170-388 9.7e-36 118.4 In-house 2-168 (178) alignment 
Range on Protein: 170-388
Range on HMM: 2-168/178.0
YDHSRVVLERVNGDEDLDYINASFIHGYdgtprSFIASQGPlppafEGFWRMVWEQNSQSIVMLTNLVGLNKTKCHKYWPDKTEtyggvtvtlhqsevfa
.|..||.|. . | |  ||||||.| ..      ...|..|     . ......|.. ..||.||. . |.. ||..|||....                
ldrtrvllsnleglersdyinaseilpg.....lylgslpp.....addlellkelgithivnlteelelgflkcdpywpeeag................

gyenctfilskekrsgsrivRQFHFTVWPDKGVPQYATAVLAFRRKVRALNPRDAGPVIVHCSVGVERTGAYIVIDAMLEQakksrTVDIRNYLIAIRKH
                     |.... .|| |||.    .|.| . .... ... |||.|||| || |.|. .... |...      ... . .  .|..
....................iqylhipipDhgvpdllehflefvefieealdekggpvlVHCsaGvgRsgtlvaaylmkkl.....glsleeaielvrer

RPhMVQTKEQYSFIHSAVL
|| .|.. .|. ...   |
Rp.ivpnpgqlrqLyefel
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 125-390 1.4e-35 117.5 In-house 18-286 (305) alignment 
Range on Protein: 125-390
Range on HMM: 18-286/305.0
AKMHGGIRLET-EYKKFNNgqqFPWGAARKPANkNKNKNRYANIVAYDHSRVVLervNGDEDLDYINASFIHGyDGTPRSFIASQGPLPPAFEGFWRMVW
 |.  |.| |    |.||.   |    | | |. ...|||| ..   |. || |   .|    .|| | ..      |. || .| ||  .   || | .
ekgpaglraefvamkrfnd...fekmkafkeaq.eagknrykdvgcldnnrvkl...egpwpheyihanyvst.ptnpkrfictqaplektcadfwymcl

EQNSQSIVMLTNLVGLNKTKCHKYWPDKT-------ETYGGVTVTLHQSEVFAGYENC------TFILSKEKRSGSRIVRQFHFTVWPDKGVPQYATAVL
... ..| || ||.     ||..|.. |        |    ..| .  |. .   ...      | .. .   . .| | ..|.  |||.|||   .|.|
qdkveaifmlcnllekgakkcleyfaskdkdvlefeekgqkisvkfessvtlkfrkdakakvtetvlviegpgekarkvthyhwidwpdrgvpaadlail

AFRRKVRALNprdaGPVIVHCSVGVERTGAYIVIDAMLEQAKKSRTVDIR-NYLIAIRKHRPHMVQTKEQYSFIHSAVLEA
 .  | |..     ||..|||| |. |||. .... .|.|    . ..     |  ||. |   .|| .|| |.|  .|. 
ellekarpsk....gpivvhcsagigrtgsvvmleyildqllagqiiedtdkilqkireqrnnsiqtdaqylfvhqvilny
subfamily_PTPN3_pd Subfamily PTPN3 441-622 4.2e-35 116.0 In-house 32-215 (280) alignment 
Range on Protein: 441-622
Range on HMM: 32-215/280.0
EKSVGEKPQNLHKNRFSDIIALNSCRVMLHKEhadeESDYINAVFLHAHR----GRNAFIATQHPLLETVEDFWRMVTDYDIGTIVMLNNLHDQVAPESS
. |.  ||.||.|||. ||.. .. ||.|...    |.||||| ..          | .|||| || .|..|||.|| . .. .|||| .| ..      
aisaarkpenlsknryrdilpydatrvklkes....etdyinanyvnmeipstglvnryiatqGPlaktatdfWqmvweqksslivmlttlverGrvkCh

EYWPDHG-ATKYGHIGISVLSKQKKGDVICVKPKVTRKK--KTHEVRHLHHVSWTDKCIPKVSRSVLDLLDEVQTSQqQCGNVPVLVQC
.|||...  ..||.. . . .....  ..  .  ...|.  . ... .| ...|.|...|. | ..|.....|.. . .  . ||.| |
qyWPetedeleygefsvkcekedetksyvlrelvlkdketkeerkilqlqylaWpdhgvPddsadflefvervrklr.sgkeePvvvhC
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 419-622 7.3e-35 115.2 In-house 19-223 (290) alignment 
Range on Protein: 419-622
Range on HMM: 19-223/290.0
MTGYALEFQRLNSvTSREIPVeekSVGEKPQNLHKNRFSDIIALNSCRVMLH--KEHADEESDYINAVFLHAHRGRNAFIATQHPLLETVEDFWRMVTDY
..|.  .|..|.| ...|  |    ||  ..| ..|||..|.  .  |..|.   .| | . .||||.... .. ....|||| |. .|. |||... . 
negfrnqfkmlds.gesehtv...tvgltssnkllnRfanivvyddnritLrpisghkDCtneyinAcyikgykekkqyiatqgpvsntlvdFWkliwqe

DIGTIVMLNNLHDQVAPESSEYWPDHGATKYGHIGISVLSKQKKGDVICVKPKVTRKKK---THEVRHLHHVSWTDKCIPKVSRSVLDLLDEVQTSQQQC
..  |||| |  ..   .   ||||.....||.. | .|. ..  . |  | .|. |..   ...| ...  .| ..   .   ..| .. |..  | . 
kvtiivmltniieegkvkCqqYWpdsdtkaygefsikllneetlneyierklevknknsagakqsvtqyqitnwdstgkvtnpqtillvieemyktqrkr

GNVPVLVQC
|| ...| |
gntsivvHC
subfamily_PTPN23_pd Subfamily PTPN23 420-622 1.9e-34 113.8 In-house 15-219 (288) alignment 
Range on Protein: 420-622
Range on HMM: 15-219/288.0
TGYALEFQRLNSVTSREipVEEKSVGEKPQNLHKNRFSDIIALNSCRVMLHkehaDEESDYINAVFLHAH-RGRNAFIATQHPLLETVEDFWRMVTDYDI
|.   .|. |..   .|   ...|.     . .|||. ||.  .. ||.|.    ... ||||| |..    |   ||||| || .|. |||.|| .   
taldkkfkeleqkqdke..arkrsiaiaklyseknrsrdilPyDhnRvklr....gskDDYinAsfvkdlspgcPdfiatqaPlqstlnDFWlmvyeqks

GTIVMLNNLHDQVAPESSEYWPDH--GATKYGHIGISVLSKQKKGDVICVKPKVT--RKKKTHEVRHLHHVSWTDKCIPKVSRSVLDLLDEVQT---SQQ
 .|||| . ...  |. ..||| .   ..|.|.. ... |... . ..  . |..  .......|.||.  ||..  .|.   ..|..||||..   ..|
sviVmllskeelgkpkvdrYwPedkgetvkfgdlsvtlksvretethvervlkletldadavksvshlqltsWpelGvPasPetllqfldevesayeavq

QCGNVPVLVQC
.  ..|..|.|
rksktPlvvhC
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 437-622 3.4e-34 113.2 In-house 14-208 (274) alignment 
Range on Protein: 437-622
Range on HMM: 14-208/274.0
IPVEEKSV-GEKPQNLHKNRFSDIIALNSCRVMLHKEHADEE-SDYINAVFLHAHRG-RNAFIATQHPLLETVEDFWRMVTDYDIGTIVMLNNLHDQVAP
.|.. .    . . . .|||. .|.  .  ||.|..|....| |.|||| ...  ..  .|..||| || .||.|||||.   ..  |||| .|...   
lPlnfdqeeldvfgsqtknryktilPnensrvllesessededssyinanyikGydeeskayvatqGPlpntvadfWrmiyqeevqvivmltklkeaneq

ESSEYWPDHGAT----KYGHIGISVLSKQKKGDVICVKPKVTRKKKTHEVRHLHHVSWTDKCIPKVSRSVLDLLDEVQTSQQQCGNV--PVLVQC
  ..|.||.  .    .||.. | | .. .. |    |  .   .....| |  . .| |.  |.  ...|||..||..|...  .   ||.| |
kCavyfPdaedyeiserygdveikvekiverndysvrklvlkylerersvkhywytdWPdhksPddantlldlvleveesreeenaklapvvvhC
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 150-390 9e-34 111.5 In-house 47-288 (305) alignment 
Range on Protein: 150-390
Range on HMM: 47-288/305.0
AARKPANKNKNKNRYANIVAYDHSRVVLERVNgdeDLDYINASFIHGYDGTPRSFIASQGPLPPAFEGFWRMVWEQNSQSIVMLTNLVGLNKTKCHKYWP
 | . |. .. ||||... . |.| | |.. .     ||| | ..       . ||..||||  . . || || ... . |||| . | | | || .|||
nanqsadiaitknryqdvpcqdqsavkldkps...psdyihanyvgcpmipekrficaqgpldqtidefwwmviqnkveqivmlcktvelgklkcaqywp

----DKTETYGGVTVT-LHQSEVFAGYENCTFILSKEKRSGSR--IVRQFHFTVWPDKGVPQYATAVLAFRRKVRAlnprDAGPVIVHCSVGVERTGAYI
    .| |  .|. |  .  |  .    .    | .   ||..   ||....| |||.|||    . | .   .|        |..|||| |. |||. .
aaqgeklelksgivvenvsgskpmerdaeiqitllnltysgdqkmsvrhlqwtewpdrgvppckltslellsairg....skvpivvhcsagigrtgtiv

VIDAMLEQAKKSR-TVDIRNYLIAIRKHRPHMVQTKEQYSFIHSAVLEA
 |. .||.  . .    . . . |.| .| . .|.  || |||  .|. 
aieyilekiaenkpcppmpelvkalrdqrafsiqndvqylfihrvmlny
subfamily_CG42327_pd Subfamily CG42327 157-317 1.4e-33 110.9 In-house 27-191 (319) alignment 
Range on Protein: 157-317
Range on HMM: 27-191/319.0
KNKNKNRYANIVAYDHSRVVLERVNGDEDLDYINASFIHGYDGTPRSFIASQGPLPPAFEGFWRMVWEQNSQSIVMLTNLVGLNKTKCHKYWPD-----K
  |.|.|..|.|   ..||||.|.  |.   |..||.. ||| .| |.||.| .|  .   |||.||||.|. || ||.|  |   .| .|.|       
tskdksrvinvvPlPetrvvlqrigdddkdeyldasyvrGyddapnsyiaaqvsledsssdfwrtvweqqsrvivqltdlselGikvcaeylPtketldn

TETYGGVTVTLHQSEVFAGYENCTFILSKEKRSGSRIVRQFHFtVWPDKGVPQYATAVLAFRRKVR
|..|| . ||| . ||   |   |..| . ... || .  . .  |.. .||   .|..|   .||
tslyGdilvtlkgrevkdryaistlllkrvdkeesrelthywy.kwleaevPaeeaaliamllevr
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 423-622 1.5e-33 111.5 In-house 37-231 (319) alignment 
Range on Protein: 423-622
Range on HMM: 37-231/319.0
ALEFQRLnsvTSREIPVEEKSVGEKPQNLHKNRFSDIIALNSCRVMLHKEHADEESDYINAVFLHAHRGRNAFIATQHPLLETVEDFWRMVTDYDIGTIV
  ||.|.   . . ..  ...  . .||  |||. .|.| .  .| |..    | |||||| |.  .. .. .||.| || .|..|||||. .|.. |||
evefrra...cklgvnladqtfanldqnkdknriinilafdknvvklerliGeefsdyinasfvtGyqrkdkyiaaqGPldntladfWrmiweyncstiv

MLNnlhdqvAPESSEYWPDHGATKYGHIGISVLSKQKKGDVICVKPKVTR---KKKTHEVRHLHHVSWTDKCIPKVSRSVLDLLDEVQT-SQQQCGNVPV
.|           |.||| ..  |...  ..| | ..  . .  . ....   .|   ...  |   | |.  |. .  .. |.. |.   ... .. ..
llt......kdkcsqywplkivikeerfkvkvdsveetaeyvvrdielsedgkekdirkitqfhflGwpdvGvpdypsdlmrlvkkvrhltskenhrani

LVQC
.| |
vvhc
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 434-622 3.4e-33 110.3 In-house 9-195 (284) alignment 
Range on Protein: 434-622
Range on HMM: 9-195/284.0
SREIPVEEKSVGEKPQNLHKNRFSDIIALNSCRVMLHKEHADEESDYINAVFLHAHRGRNAFIATQHPLLETVEDFWRMVTDYDIGTIVMLNnlhdqvAP
 . ..  ...  . .||  |||. .|.| .  .| |..    | |||||| |.  .. .. .|||| || .|..|||||. .|.. |||.|         
klgvngtdqtfanldqnkdknrighilafdknvvklerliGeefsdyinasfitGyqrkdkyiatqGPldntladfWrmiweyncstivllt......kd

ESSEYWPDHGATKYGHIGISVLSKQKKGDVICVKPKVTR---KKKTHEVRHLHHVSWTDKCIPKVSRSVLDLLDEVQT-SQQQCGNVPVLVQC
  |.||| ..  |...  ..| | ..  . .  . ....   .|.  ..|  |   | |.  |. .  .. |.. |.  .... .. ...| |
kcsqywplkivikeerfkvkvdsveeseeyvvrdielsedgkekdirkirqfhflgwpdvgvpdypsdlmrlvkkvrhltskenhranivvhc
subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 157-389 9.6e-33 108.0 In-house 36-267 (281) alignment 
Range on Protein: 157-389
Range on HMM: 36-267/281.0
KNKNKNRYANIVAYDHSRVVLER-VNGDEDLDYINASFIHGyDGTPRSFIASQGPLPPAFEGFWRMVWEQNSQSIVMLTNLVGLNKTKCHKYWPDKTE--
 |..||||.|| . | ||| |.  .   .  ||| | .|.      | .| .|||   .   ||||.|..|. .|||| ...  |. || .|.| ..   
vnnkknrylnipcldisrvqlkvkmpnknstdyihanyirs.pflkrgyiltqgpkketradfwrmiwqenttaivmlcqfletnrekcaeyfprnahcc

-TYGGVTVTLHQSEVFAGYENCTFILSKEkrSGSRIVRQFHFTVWPDKGVPQYATAVLAFRRKVRAlnpRDAgPVIVHCSVGVERTGAYIVIDAMLEQAK
  .  ..|.  .| |        . || |    .|.. .. .  |||  ||. .  .|   ||.||   | . | ..||| || |.|. . ..  |.  .
lqfdklsvsyedstvnkslvttrlnlsye..getrlithwlwkewpdwqvpessevmlkilrkira...rst.ppvihcsagvgrsgtlmaveialqsih

KSRTV-DIRNYLIAIRK-HRPHMVQTKEQYSFIHSAVLE
   |. ||.. .  .|   |   ||| .|| .|   .|.
shftlpdikqivshlrvtgraasvqtlqqymliwkvlld
subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 153-399 1.9e-32 107.1 In-house 47-297 (310) alignment 
Range on Protein: 153-399
Range on HMM: 47-297/310.0
KPANKNKNKNRYANIVAYDHSRVVLErVNGDEDLDYINASFIHGyDGTPRSFIASQGPLPPAFEGFWRMVWEQNSQSIVMLTNLVGLNKTKCHKYWPD--
.  .|.  ||||...|  | ||| |. ..     ||| | ...  .    .|| |||||  .   ||||.... ..||..| . .   . ||  |||   
eaykkymhknrysdvvcldtsrvklk.idksryedyihanyvkt.nylrstficsqgplqhtiidfwrmifqeraesilllckvgeegrpkcvgywpslg

KTETYGGVTVTlHQSEVFAGYENC----TFILS----KEKRSGSR--IVRQFHFTVWPDKGVPQYATAVLAFrrkvRALNPRDAGPVIVHCSVGVERTGA
 ||||| . ||   ||    .| |    ||.       |. .  .   |   ..  |||.|||.     .      | |     ||..|||| |..|...
vtetygcirvt.nlsesseefeicnlavtfvpdnvpvdeqpanlkelrvslikwpnwpdrgvpdekchtvpq....rllaqvrhgpcvvhcsagkdrlyv

YIVIDAMLEQAKKSRTVDIRNYLIAIRKHRPHMVQTKEQYSFIHSAVLeALTCGNTEIQ
 . ..  ......   ||. .    ..|.|   .||. || .|.   . ... |.||. 
vvalklkidkldrglkvdaeevktellksraiciqtelqyliidrvri.ifargeteva
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 272-415 4e-32 106.1 In-house 78-218 (440) alignment 
Range on Protein: 272-415
Range on HMM: 78-218/440.0
ENCTFILSKEkrsgSRIVRQFHFTVWPDKGVPQYATAVLAFRRKVRALN-PRDAGPVIVHCSVGVERTGAYIVIDAMLEQAKKSRTVDIRNYLIAIRKHR
 |...| . |    || ..|.|.  |||||||..|  || . . |   .     ||..||||.|. |||  |..|..| .||.|  .|| ... ..|. |
inasyingie....srtlkqyhyqgwpdkgvpkfagpvlkmiqdvnesqekagngpllvhcsagagrtgviiavdsilreakrsdqidifsfinsmrnnr

PHMVQTKEQYSFIHSAVLEALTCGNTEIQSEKYNQAMQKLASVNG
|.|||| |||.|.| ||||.| ||.| |  .   . ....   | 
pqmvqtpeqyafvheavlegllcgdtliledditerveqiqwpnp
0051082 (Phosphotyrosine protein) phosphatases II 186-388 4.4e-32 106.1 In-house 3-150 (151) alignment 
Range on Protein: 186-388
Range on HMM: 3-150/151.0
LDYINASFIHGYdgtprsFIASQGPLPpafeGFWRMVWEQNSQSIVMLTNLVGLNktKCHKYWPDKTetyggvtvtlhqsevfagyenctfilskekrsg
 ||||.|.. |.      ...|.|||.     |.....|.. ..||.|....  .  .|..|.|.                                   
sdyinfsyvtgg......lyrsggpla....dflellkelgiktivnlrseeerg..ycpeylpelg.................................

sRIVRQFHFTVWPDKGVPQYATAVLAFRRKVRAlnpRDAGPVIVHCSVGVERTGAYIVIDAMLEQakksrtVDIRNYLIAIRKHRPHMVQTKEQYSFIHS
 . |...... ||| |.|..  |||.| .....    . |||.|||| |. |||. .... ||..      |..   |  .|..||..||...|. |.. 
.ievlhipildwpdpglplsfdavleflellld...kkngpvlvHCsaGkgRTGtlvalylmllg......vsleealeeyrlkrpgvvqpnqqflfqlf

AVL
|.|
all
subfamily_PTPRN_pd Subfamily PTPRN 440-623 5.3e-32 105.7 In-house 46-232 (297) alignment 
Range on Protein: 440-623
Range on HMM: 46-232/297.0
EEKSVGEKPQNLHKNRFSDIIALNSCRVMLHKEHADEESDYINAVFLHAHRGRN-AFIATQHPLLETVEDFWRMVTDYDIGTIVMLNNLHDQVAPESSEY
. |.|.....|..||| ..... .  || |..| ..|.|||||| ..  |  |. |.|||| || .|| |||.|| .  .  ||.| .|...   . ..|
stkevakaeknvkknrskavlpydhsrvklkeeasaeksdyinasaildhdprapayiatqgplastvadfwqmvweqGvvvivnltrleeegvkqckry

WPDHGATKYGHIGISVLSKQKKGDVICVKP---KVTRKKKTHEVRHLHHVSWTDKCIPKVSRSVLDLLDEVQTSQQQcGNVPVLVQCR
|||.|.  |.   . ..|.    |   |.    |  ....|  |  .|..||... .|  ..|.|..   |. | .     |..| | 
wpdeGsevyhiyevhlvsehiwcddylvrsfylknlqtsetrtvtqfhflswpeegvPasaksllefrrkvnksyrG.rscpivvhcs
PTPc_DSPc_SM00012 289-389 1.1e-31 104.5 In-house 2-105 (105) alignment 
Range on Protein: 289-389
Range on HMM: 2-105/105.0
VRQFHFTVWPDKGVPQYATAVLAFRRKVRALNPRDA--GPVIVHCSVGVERTGAYIVIDAMLEQAKKS-RTVDIRNYLIAIRKHRPHMVQTKEQYSFIHS
|...|.| |||.|||......| . |.|.  .   .  .||.|||| || ||| ....| .|.| .|. ..||| ... ..||.||.||||.|||.|.. 
vkhyhytgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqylflyr

AVLE
|.||
alle
subfamily_ptpA1_pd Subfamily ptpA1 155-349 1.7e-31 104.4 In-house 44-254 (418) alignment 
Range on Protein: 155-349
Range on HMM: 44-254/418.0
ANKNKNKNRYANIVAYDHSRVVLERVNGDEDLDYINASFIHGydGTPRSFIASQGPLPPAFEGFWRMVWEQNSQSIVMLTNLVGLNKTKCHKYWPDKTET
 ..| .||||.||.  .|.|| |....  |  ||||| .| |    |. ||..||||| .   |||||||.  . ||||.      . || .|||..   
kkhntsknrytnilpvnhtrvqlkkiqdkegsdyinanyidg..aypkqfictqgplpntiadfwrmvwenrcriivmlsresencrikcdrywpeqigg

yGGVTVTLHQSEVFAGYE--NCTFILSKEK-----------RSGSRIVRQFHFTVWPDKGVPQYATAVLAF-----RRKVRALNPRD-AGPVIVHCSVGV
   ...     |||  |       |   |.              .| . |...  |||. .|...  .  .      |. . .   |   |.||||| ||
.eqfsiygngnevfgtysvelveviqdpereiitrnirltfegetrditqyqyegwpdhnipdhtqpfrqllhsitnrqnqiipssdrnvpiivhcsagv

ERTGAYIVIDAMLE
 |||..     |..
grtgtfctavimmk
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 440-622 3.9e-31 103.0 In-house 10-204 (270) alignment 
Range on Protein: 440-622
Range on HMM: 10-204/270.0
EEKSVGEKPQNLHKNRFSDIIALNSCRVMLHKEHADEESDYINAVFLH-AHRGRNAFIATQHPLLETVEDFWRMVTDYDIGTIVMLNNLHDQVAPESSEY
.|... |  .. . ||. ||.     ||.|.... |... |||| ... ..  ....||.. ||  |...||||. .    .|||. .|...   . . |
sesdlpeaargkklnRyadiLPsPatRvrleeleedsataYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkgrkkCerY

WPDHGAT----KYGHIGISVLSKQKKGDVICVKPKVTRKKKTHEVRHLHHVSWTDKCIPKVSR------SVLDLLDEVQTSQQQCGNV-PVLVQC
|| .  .    ..|.| . .||..|.   |  . ....| ..... | ....| |. .|. .       ..| .| .|. |...  .  |.|| |
WpaepkekvkledgkikvlalseekeegyiltrlrleekgeerrlvHfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkaePllvHc
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 424-623 1.7e-30 100.9 In-house 10-207 (283) alignment 
Range on Protein: 424-623
Range on HMM: 10-207/283.0
LEFQRLNSVTsreIPVEEKSVGEKPQNLHKNRFSDIIALNSCRVMLHKEHAdeesDYINAVFLH---AHRGRNAFIATQHPLLETVEDFWRMVTDYDIGT
| ...|. ..   .|  .  .    .| .|||. .|.. .  || |. |      |||||||.     ..  . .|..| || .|| |||.|| | .| .
lfrevlkrls...vpdldadiasadenkrknrnqeivpadqwrvelksesr....dyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfdekita

IVMLNNLHDQVAPESSEYWPDHGATKYGHIGISVLSKQKKGDVICVKPKVTRK---KKTHEVRHLHHVSWTDkCIPKVSRSVLDLLDEVQTSQQQCGNVP
|||| .| ..   . | ||| .|. .||   ...     .   |  .  .  .   |.|  . |   . |.. . ..     |  .. |.. |..  . |
ivmltklqedlrikCsqyWPkrGsedyGeftvtlrkettsnsfiikelllrvnssakstlllahyqvidWle.ygeqaiinslvkfnkvislqteskkgP

VLVQCR
..| | 
ivvhCs
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 157-399 2.6e-30 100.5 In-house 42-279 (288) alignment 
Range on Protein: 157-399
Range on HMM: 42-279/288.0
KNKNKNRYANIVAYDHSRVVLErvngdEDLDYINASFIHGYDGTPRSFIASQGPLPPAFEGFWRMVWEQNSQSIVMLTNLVGLNKTKCHKYWPDKTETY-
.|  ..|| |.   | .|| |.     .| |.  |. .      .| .| .| ||  . | .|.|. |.. . ||||..|. . | |  .|.| |     
anptrdryenlprcditrvkls.....ddpdfyiaanvvssakykrrlicaqaPlngtieelWkmllesdveyivmlcellekGkeksaeyfPsklGeka

--G-GVTVTLHQSEVFAGYENCTFILSKEKRSGSRIVRQFHFTVWPDKGVPQYATAVLAFRRKVRALNprdaGPVIVHCSVGVERTGAYIVIDAMLEQAK
  |   ||. .. .      . . .  ...   . ||.. |.  |.|.|||.   . | .   ...|.     |..||.| || |||. |.|  .||...
rigrlctvvkkkradidklvkvsllriskegeekvivkilhlleWdddgvPenylsplrllevlkslq....kPivvhssaGvGrtgtlililialeslr

KSRTVDIRNYLIAIRKHRPHMVQTKEQYSFIHSAVLEALTCGNTEIQ
 .  . ||. |   |..| . .||. || ..|  ||| |     . .
lddflgirsllaklreerfkaiqtemqylyvhrcvleelllkkykvl
subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 156-397 7.7e-30 98.7 In-house 41-282 (312) alignment 
Range on Protein: 156-397
Range on HMM: 41-282/312.0
NKNKNKNRYANIVAYDHSRVVLervNGDEDLdYINASFIHGYdGTPRSFIASQGPLPPAFEGFWRMVWEQNSQSIVMLTNLVGLNKTKCHKYWPDKTety
 | |. ||| ||  .|  |  |    |||.. || | |..     |  |...||||  .   ||...    | ||..|. .|     || ||  |     
lkfkdlnrypniqcwdrgrftl...agdenf.yihanfvkic.tkperfvctqgplentcthfwqlalslgstsiillcgfvedgsekcakyisdiv...

GGvtVTLHQSEVFAgyENCTFIL----SKEKRS-----------GS-RIVRQFHFTVWPDKGVPQYATAVLafrRKVRALNpRDAGPVIVHCSVGVERTG
|   | | .  |..  | || |     ||.| .           |    . .. .. |||.|.|.   . |   | . |.. .|  ||| ||| || |||
gf..vdledhrvyt..eycteieiggkskdkithrvlkvvvkatgqesklnhyqwaswpdhgmpdscdtal...rllsavk.kdkkpviahcsagvgrtg

AYIVIDAMLEQAKKSRTVDIRNYLIAIRKHRPHMVQTKEQYSFIHSAVLEALTCGNTE
. ..|..|.   .. |  .... .. .|| |   |..  || .   .||| | .    
tlaliesmiaalrhprkqnvkdsfvllrkdrarsvrvfpqyvyalrcvleflyskgly
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 150-315 2.7e-29 97.0 In-house 27-192 (297) alignment 
Range on Protein: 150-315
Range on HMM: 27-192/297.0
AARKPANknKNKNRYANIVAYDHSRVVLERVNGDEdlDYINASFIHGY-DGTPRSFIASQGPLPPAFEGFWRMVWEQNSQSIVMLTNLVGLNKTKCHKYW
.|....     |||| .|.|.| .|| | ||  ..  ||||| ..    . ..  .| .||||  . . ||..|.||. . |||...|    . ||  ||
sakrnss..lrknryrdilatddtrvkllrviter..dyinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmvaklqedGrdkcapyw

PDKTE--TYGGVTVTLHQSEVFAGYENCTFI-LSKEKRSGSRIVRQFHFTVWPDKGVPQYATAVLAFRRK
|.  .     |  |  . |..   ...  .  |    || || ||   |  |||.|||     .  |. .
psvvqerlkagdvvveflsstsdefdrviltelqliyrsesrvvrhvqflswpdhGvpsdledlvrfqaq
subfamily_CG7180_pd Subfamily CG7180 420-623 4e-29 96.2 In-house 13-231 (296) alignment 
Range on Protein: 420-623
Range on HMM: 13-231/296.0
TGYALEFQRLNSVTSReIPVEEKSVGEKPQNLHKNRFSDIIALNSCRVMLHKEHADEESDYINAVFLHAHRGRNAFIATQHPLLETVEDFWRMVTDYDIG
  . .|.. .  .|.| .  ..   | . .|. |||  ...  .  ||.|.| . .|.|||||||.  ..   ...| |. |  |||..|||.| | .| 
rkfrveyklelkltpr.leigdCagglrkenreknrdvkvvPyDynRvvLekldGeeksdYinavyvdsflkkkeyivteapkketvdefWrlvydeeis

TIVMLNNLHDQVApESSEYWPDHGATKYGHIGISVLSKQKKGDVICVKPKVTRK------------KKTHEVRHLHHVSWTD-KCIPKVSRSVLDLLDEV
..|.| .  |.      .||| .. ..||.| . ......  ..   . |.|.|             .|  |....   |   . .| .. ....|.  |
avvvLtktfdfak.mypsywpnkskeqygeifveiveekqyanlkirtfkltkkivalteqekqvkaetRivklfqlteWeledkvPlstnalielrrrv

QTSQQQC----GNVPVLVQCR
.. ...      . ||.| . 
rlwrekvdedpeegPvvvvss
subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 156-391 5.7e-29 96.0 In-house 33-270 (285) alignment 
Range on Protein: 156-391
Range on HMM: 33-270/285.0
NKNKNKNRYANIVAYDHSRVVLErvngDEDLDYINASFIHGYDGTPRSFIASQGPLPPAFEGFWRMVWEQNSQSIVMLTNLVGLNKTKCHKYWPDKTE--
. | . ||||.. . . .||||.    . | ||| ||...       ..|..||||| ..  ||.|.....   ..||  |.     ||  |.|.|    
eanpdlnryadvrcieetrvvlk....nhdrdyihaswmrmpgkdqstyittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekcalyypeklgev

-TYGGVTVT--LHQSEVFAG--YENCTFILSKEKRSGSRIVRQFHFTVWPDKGVPQYATAVLAFRRKVRALNPRDAgPVIVHCSVGVERTGAYIVIDAML
  .|   .|    . |  ||  ... | | ...  |    . . .   |||.  |. |  .. . . |. .||..  |. |||| || || ... ||   
vkfgkyeitlteckeeaiagtilnaltvintedasseplymnhvqvpwwpdqlapedarpmielykwvkkvnpkek.picvhcsagvgrtatfvgidyat

EQAKKSRTVDIRNYLIAIRKHRPHMVQTKEQYSFIHSAVLEAL
 .  .   ... . .  .|  | . ||.. |. |..  ..| .
irimenpniemldivremramrfqavqshmqflflyvvlmeyf
subfamily_PTPN1_pd Subfamily PTPN1 442-622 8.7e-28 91.8 In-house 24-208 (290) alignment 
Range on Protein: 442-622
Range on HMM: 24-208/290.0
KSVGEKPQNLHKNRFSDIIALNSCRVMLHKEHAdeesDYINAVFLHAHRGRNAFIATQHPLLETVEDFWRMVTDYDIGTIVMLNNLHDQVAPESSEYWPD
 .. ..|.|  .||. |.   . .|..|....     ||||| ...... .  .| || || .||. ||.|| . .  ..||||.. ..      .||| 
treaklpenrnlnryrdvspydhsrikleradn....dyinaslveleeakrsyiltqGPlpntvdhfWqmvWeqkskavvmlnkvvekeqikcaqywPq

HG---ATKYG--HIGISVLSKQKKGDVICVKPKVTR--KKKTHEVRHLHHVSWTDKCIPKVSRSVLDLLDEVQTSQQQCGNV-PVLVQC
.    . ..   .. . ..|...|   .  . ...    ..|.|. | |...|.|  .|.   . |..| .|. |     .| |... |
geeekellledtklkvkliseerksyytvrllelenlktqetreilhfhyttwpdfgvpespaaflkflfkvresGslssdvGpavihc
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 447-623 5.8e-27 89.2 In-house 45-220 (439) alignment 
Range on Protein: 447-623
Range on HMM: 45-220/439.0
KPQNLHKNRFSDIIALNSCRVMLHKEHADEESDYINAVFLHAHRGRNAFIATQHPLLETVEDFWRMVTDYDIGTIVMLNNLHDQVApesseYWPDHGATK
.  .  |||. |. |..  ||.|..      | |||| ... .   . .|||| |  ||..||||.| .    ||||| || .        |||  . . 
qeydqtknrykdvgafdhtrvtlqeipgvphshyinanyikGyyddklyiatqgpkkettddfwrlviekktvtivmltnlvesyk.....ywpsdaevc

YGHIGISVLSKQKKGDVICVKPKVT----RKKKTHEVRHLHHVSWTDKCIPKVSRSVLDLLDEVQTSQQQCGNVPVLVQCR
|| | . |  . .  . .    ||     . .| . | ..|...| || .|  .  |||.|  .......    ||.|.| 
ygdiavrvdrnielpnyvirgfkvfnerdttekertvlqfhyiawpdknvpaqashvldflrainsandkeeygpvvvhcs
subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 158-409 6.4e-27 89.1 In-house 50-298 (301) alignment 
Range on Protein: 158-409
Range on HMM: 50-298/301.0
NKNKNRYANIvAYDHSRVVLERVNGDEdlDYINASFIHGYdGTPRSFIASQGPLPPAFEGFWRMVWEQNSQSIVMLTNLVGLNKTKCHKYWPDKTET---
.|.|.|| ..   . |  |   |.|      | | .|    | |. |||.||||. . | || |.   . . ||||.. |  ...||..| | |..    
pkdkhryptv.PckPstavevivdGkr..vPihanwipts.GhphrfiatqgPlkntsedfwamlvqydvekivmlgqkvekleekceeylpvkisekld

YGGVTVTLHQSEVFAGYENCTFILS---KEKRSGSRIVRQFHFTVWPDKGVPQYATAVLAFRRKVRalnpRDAGPVIVHCSVGVERTGAYIVIDAMLEQA
 |  .......|.    .     |      ..  .| |  . .. |.|.|||.  . .  .   |.    .   |..|||| |. |. |.|  . .  . 
igrfkikiknkelilnkkiskrtlevedstgkfatrtvthyqysewtdrgvPkshaelfdlmelvk....ksekPivvhcsaGiGrsvafigteylarev

KKSRTVDIRNYLIAIRKHRPHMVQTKEQYSFIHSAVLEALTCgNTEIQSEKYNQAMQK
.  .|... . |  .|.|| . |||..|  ..    .  |   . ...   |.. .. 
eadptieltealkhlrehrwngvqtnsqlywmtlGtvyrlik.eygfdmkiyeeqlam
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 440-622 1.3e-26 88.0 In-house 30-233 (301) alignment 
Range on Protein: 440-622
Range on HMM: 30-233/301.0
EEKSVGEKPQNLHKNRFSDIIALNSCRVMLHKEHA--DEESDYINAVFLHAHRGRNAFIATQHPLLETVEDFWRMVTDYDIGTIVMLNNLHDQVAPESSE
.. .|| . .| . ||| .|  ..  |..|.....    . .|||| .... . ...|||.| |. .|. ||||.. ..   .|||. ||...   .. .
ksctvglseenkalnrfknitvyddnriilkpkpnldlcqreyinasyidgysekkkfiaaqgpmkktlvdfWrliwqekpvsivmvtnlkegtkskceq

YWPDHGATKYGHIGISVLSKQKK--G-----------------DVICVKPKVTRKKKTHEVRHLHHVSWTDKCIPKVSRSVLDLLDEVQTSQQQCGNVPV
|||.  |...    ..|. ....                      |  | ||...|....|  |. ..| .  . .  | ||  .|.|   ||. |  ||
ywpnseaeseefgpftvtlvneqvyPdfvirqlnvkiqdgsnngyierkfkvksdksswdvlqlqvtdWpqdGvvreprtvLqviddvihrqqkigggpv

LVQC
.| |
vVHC
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 438-622 1.4e-26 87.8 In-house 33-176 (392) alignment 
Range on Protein: 438-622
Range on HMM: 33-176/392.0
PVEEKSVGEKPQNLHKNRFSDIIALNSCRVMLHKEHADEESDYINAVFLHAHRGRNAFIATQHPLLETVEDFWRMVTDYDIGTIVMLNNLHDQVapesse
.. ...|..|. ||.|||. .|. ..| ||.|       .|||.|| ....    .|.||.| |   ...|||||| . .. ||.|...|..        
diypqtvaqkeinlkknryknilpydsarvkleviddipdsdylnasyipsfdnekayiasqgpnaaslddfwrmvfqenvttiamvtklkegd......

ywpdhgatkyghigisvlskqkkgdvicvkpkvtRKKKTHEVRHLHHVSWTDKCIPKVSRSVLDLLDEVQTSQQQCGNvPVLVQC
                                  . .... |   | . | || .|| . |.| .. ||..   |    |....|
..................................kgddartvaqfhftewPdkdvpkhtssllkfikevkadfGqyth.pliihc
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 405-622 2.3e-26 87.1 In-house 12-223 (290) alignment 
Range on Protein: 405-622
Range on HMM: 12-223/290.0
QAMQKLASVNGKFPMTGYALEFqrLNSVTSR-EIPVEEKSVGEKPQNLHKNRFSDIIALNSCRVMLHKehaDEESDYINAVFLHAHrgRNAFIATQHPLL
.|..|.||   |  . ..| |.  |. .         |... .|  ...|||. |..  .  ||.|.      . ||. | ...    .  || || .| 
eafekfasdvvkknvdelakey..leklkpylpvqylerkifdkntefkknrykdvvcndktrvilkd...GydGdyvhanyvkGl..kamfiltqGalk

ETVEDFWRMVTDYDIGTIVMLNNLHDQVAPESSEYWPDHG--ATKYGHIGISVLSKQKKGDVICVKPK-VTRK--KKTHEVRHLHHVSWTDKCIPKVSRS
.|| |.|||| . .. .|||| .| ..  .  ..|.|..   .  .|.| .    ...| . |  |   |  |   | | ..||. .|| ||.... . .
dtvidiwrmvlqekvaaivmlceliedGkakceqyypekeGevltfGeitvlcseeddkdaniikktlsvrdkdsGkehklkhlkikswpdksvalstla

VLDLLDEVQTSqqqCGnvPVLVQC
.| .|  ...     |  || | |
llrtlrilrka...sG..pvvvhc
subfamily_PTPN14_pd Subfamily PTPN14 441-612 2.9e-26 87.2 In-house 40-218 (300) alignment 
Range on Protein: 441-612
Range on HMM: 40-218/300.0
EKSVGEKPQNLHKNRFSDIIALNSCRVMLHKEHADeESDYINAVFLHAHRG--RNAFIATQHPLLETVEDFWRMVTDYDIGTIVMLNNLHDQVAPESSEY
. |... |.| .|||| |..  . .|| |   . . ...||||  ...  |  .  .|..| ||  ||.|||.|| . ..  |||| . ...    | .|
llstaklpenaeknrfkdvlPyednrvelsptken.stgyinassikvsvggkersyivaqgPleltvqdfWqmvWeqgvqlivmlteeeedgkeksfky

WPDH----GATKYGHIGISVLSKQKKGDVICVKPKV--TRKKKTHEVRHLHHVSWTDKCIPKVSRSVLDLLDEVQTSQQQ
.|..       ..|.  ..   ... . ||  . |.     |.  .| || .. |.|. .|.  .. |. |.|||  ...
fPkleskkktvefgkfkvttkfsedsdsvittglklkhlpskeertvwhlqytDWpdhgvPeDvkgflsyLeevqsvrrk
subfamily_PTPN13_pd Subfamily PTPN13 425-622 9e-26 85.7 In-house 16-209 (273) alignment 
Range on Protein: 425-622
Range on HMM: 16-209/273.0
EFQRLNSVTsreiPVEEKSVGEKPQNLHKNRFSDIIALNSCRVMLHKEHAdeesdYINAVFLHAHRGRNAF--IATQHPLLETVEDFWRMVTDYDIGTIV
||. |. .     |... .||.| .| .|||. ...  .  || | .| .     |||| ..... | . .  ||.| || |||.|||.|| . .   |.
efkelrelk....pldtcevgkkkenkdknryrnvlPydetrvklgdegg.....yinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweqkaevia

MLNNLHDQVAPESSEYWPDHGATK---YGHIGISVLSKQKKGDVICVKPKV--TRKKKTHEVRHLHHVSWTDKCIPKVSRSVLDLLDEVQTSQQqcGNVP
|. .  ..       |||..   |   .. . ...|  ||. .    . .|  .. ....|| ||. |.| |  .|. . ..| .. ||.. |.   . |
mvtlekekgkvkchrywPesknkklkvsnrlevellkvqkldgfvvralavkdsesgesrevahlnfvkwPdhgvPssaaellqfvaevrrlqt..dagP

VLVQC
..| |
ivvhc
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 436-598 2.4e-24 80.7 In-house 19-185 (297) alignment 
Range on Protein: 436-598
Range on HMM: 19-185/297.0
EIPVEEKSVGEKPQNLHKNRFSDIIALNSCRVMLHKEHadEESDYINAVFLH--AHRGRNAFIATQHPLLETVEDFWRMVTDYDIGTIVMLNNLHDQVAP
|   |. |.  ..  |.|||. ||.| .. || | .     |.||||| ..          .| .| || .||.|||..|.. |...|||. .| ..   
eargesfssakrnsslrknryrdilatddtrvkllrvi..terdyinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmvaklqedGrd

ESSEYWPD--HGATKYGHIGISVLSKQKK--GDVICVKPKVTRKKKTHEVRHLHHVSWTDKCIPKVSRS
    |||.   .  | |.. .  ||.       ||  . ..  ....  |||  ..|| |. .|     
kcapywpsvvqerlkagdvvveflsstsdefdrviltelqliyrsesrvvrhvqflswpdhGvpsdled
0041856 (Phosphotyrosine protein) phosphatases II 450-624 3e-24 81.0 In-house 1-118 (182) alignment 
Range on Protein: 450-624
Range on HMM: 1-118/182.0
NLHKNRFSDIIALNSCRvmlhkehadeESDYINAVFLHAHRGRNAFIATQHPLLETVEDFWRMVTDYDIGTIVMLNnlhdqvapeSSEYWPDHGatkygh
||.|||.|||.  .  |           .||||| ..   .  . |||||.|||.||.||.||. ...|.|||.|.         .  |||..       
nldknrysdilpydhsr..........dldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt.........eelywpell......

igisvlskqkkgdvicvkpkvtrkkkTHEVRHLHHVSWTDKCIPKvSRSVLDLLDEVQTsqqqcGNVPVLVQCRY
                          .... ......| | ..|   ...||...||.       . |||| |..
..........................erlgiqylylpwpDhgvpd.ldelldfieevle.....eggpvlVHCsa
0048076 (Phosphotyrosine protein) phosphatases II 276-388 2.2e-23 77.9 In-house 34-140 (145) alignment 
Range on Protein: 276-388
Range on HMM: 34-140/145.0
FILSKEKRSGSRIVRQFHFTVWPDKGVPQYATAVLAFRRKVRALNPRDaGPVIVHCSVGVERTGAYIVIDAMLEqakksRTVDIRNYLIAIRKHRPHMVQ
. |. |..  .| . |.... ||| |||. .  .|.| . .... ... |||.|||| || |||...... ||.     . |.. . |  .|..||..|.
lnltselellerlgiqylylpwpDhgvpdllellleflefieealkeg.gpvlVHCsaGvgRtgtlvaaylmll.....lgvsleealelvrsqrpgavp

TKEQYSFIHSAVL
. .|. |.. ..|
npgqlrflyefel
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 446-622 3.4e-23 76.9 In-house 34-217 (287) alignment 
Range on Protein: 446-622
Range on HMM: 34-217/287.0
EKPQNLHKNRFSDIIALNSCRVMLHKEhADEESDYINAVFLHAHRGRNAFIATQHPLLETVEDFWRMVTDYDIGTIVMLNNLHDQVAPESSEYWPD-HGA
|.  . .|||..|.. ..  ||.| .| ..  |||||| .. ...  .||||.| |.  || ||||.| .    .....    ..   .  .|||. .  
eelaavkknryadvlPiddtrvllsae.gelGsdyinanyvasytddeafiaaqgPiaatvrdfwravletrsasvitmtreveearlkcykywPerevP

TKYGHIGISVLSKQKKGDVICVKPKVTRKKKTHE---VRHLHHVSWTDKCIPKV----SRSVLDLLDEVQTSQQQCGNVPVLVQC
 . |   . .|....|    .|.     . .|.|   |. |. .|| || ..       | |||  . .. ...  .  |..| .
mrvGGysvvlldydikePeygvralrlidletrearvvkqldllswPdkvlaPtavglirfvldvkqhielardasevGPlvvhd
subfamily_egg_pd Subfamily egg 156-388 4.5e-23 76.4 In-house 38-267 (307) alignment 
Range on Protein: 156-388
Range on HMM: 38-267/307.0
NKNKNKNRYANIVAYDHSRVVLERVNGDEDLDYINASFIHGYDgTPRSFIASQGPLPPAFEGFWRMVWEQNSQSIVMLTNLVGLnkTKCHKYWPDKtETY
. |..| |   .   | ||| ||  .|    |.| |  ..|       || .| ||  . . |||||.... | |||||  .     .|. |||   |. 
dnnlekarskrvhckdssrvklelrrGqylddfihanrvkGkp.llnefilaqaplkntvddfwrmvfqeevqyivmltsrkes..erceyywpka.esd

GGVT--VTLHqSEVFAGYE--NCTFILSKEKRSGSRiVRQFHFTVWpdKGVPQYATAVLAFRRKVRALNpRDAGPVIVHCSVGVERTGAYIVIDAMLEQA
  ||   .|.  | .  ..  .  | ..| |  |.    . .   |  .|  .... |    | .| |  . . ||.|..  || .... . |.  | . 
slvtvpGslr.ienlkvdskadplfrvtklklvGgd.deerflehw..qgdvnnssdvysplrvlrklr.nlskpvvvqdilGvskaatlvaieiallsl

KKSRT--VDIRNYLIAIRKHRPHMVQTKEQYSFIHSAVL
 .  .    ...    .|..|.  |..  .| |..  ||
lrGpitkslvlravvflrlrrrlsvesvllylfvyrlvl
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 449-622 5.6e-23 76.4 In-house 2-179 (237) alignment 
Range on Protein: 449-622
Range on HMM: 2-179/237.0
QNLHKNRFSDIIALNSCRVMLHKEHADeeSDYINAVFLHAHRGR-NAFIATQHPLLETVEDFWRMVTDYDIGTIVMLNNLHDQVAPESSEYWPDHG-ATK
.|  |||...|.| . .||.|.   ..  |||||| .|.   |  . .||.| ||  . .|||.|| .     ||||  | ..      .|||.    . 
enkiknrygnivaydhsrvvlkgagsg..sdyinatylkgfdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywpstdqpaa

YGHIGISVLSKQKKGDVICVKPKVTRKKKTHEVRHLH---HVSWTDKCIPKVSRSVLDLLDEVQT-SQQQCGNVPVLVQC
|| . .|.  |..  |       .... . .||| .|     || |. .|. . ..| .  ..   |.      | .. |
ygvltvslkkkeefsdytvrslllskrltlkevrlihqyqftswpdrgvpqqtaallrfrkniinrsphvsesgpwiihc
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 447-622 8.5e-23 75.8 In-house 5-181 (239) alignment 
Range on Protein: 447-622
Range on HMM: 5-181/239.0
KPQNLHKNRFSDIIALNSCRVMLHKEHADEESDYINAVFLHAHRGR-NAFIATQHPLLETVEDFWRMVTDYDIGTIVMLNNLHDQVAPESSEYWPDHgAT
|  |  |||...|.. .  ||.| |   |  |||||| .|. . |  .|.||||  .  .  |||||. .     ||||  | .    .  .||||  ..
krvnkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpds.ts

KYGHIGISVLSKQKKGDVICVKPKVTRKKKTHE--VRHLHHVSWTDKCIPKVSRSVLDLLDEVqTSQQQCGNVPVLVQC
||  . ...   .   | |     ...  .| |  | . |   | || .|. . .|| |  .. | .   |  | ...|
kycnlrvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrki.tkdslpgarpwvihc
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 447-622 9.3e-23 75.6 In-house 4-180 (239) alignment 
Range on Protein: 447-622
Range on HMM: 4-180/239.0
KPQNLHKNRFSDIIALNSCRVMLHKEHADEESDYINAVFLHAHRGR-NAFIATQHPLLETVEDFWRMVTDYDIGTIVMLNNLHDQVAPESSEYWPDHgAT
|  |  |||...|.. .  ||.| |   |  |||||| .|. . |  .|.||||  .  .  |||||. .     ||||  | .    .  .||||  ..
krvnkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpds.ts

KYGHIGISVLSKQKKGDVICVKPKVTRKKKTHE--VRHLHHVSWTDKCIPKVSRSVLDLLDEVqTSQQQCGNVPVLVQC
||  . ...   .   | |     ...  .| |  | . |   | || .|. . .|| |  .. | .   |  | ...|
kycnlrvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrki.tkdslpgarpwvihc
0048179 (Phosphotyrosine protein) phosphatases II 281-385 1.3e-22 75.5 In-house 41-139 (144) alignment 
Range on Protein: 281-385
Range on HMM: 41-139/144.0
EKRSGSRIVRQFHFTVWPDKGVPQYATAVLAFRRKVRALNPRDaGPVIVHCSVGVERTGAYIVIDAMLeqakkSRTVDIRNYLIAIRKHRPHMVQTKEQY
|. .  | . |.... ||| |||.... .|.| . .... ... |||.|||| || |||...... |.      . ... . |  .|..||..|.. .|.
epefleregiqylhlpwpDhgvpdllellleflefieealeeg.gpvlVHCsaGvgRtgtlvaaylmk.....klglsleealalvrsrrpgavpnpgql

SFIHS
 |.. 
rfLle
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 449-623 2.6e-22 74.2 In-house 42-212 (288) alignment 
Range on Protein: 449-623
Range on HMM: 42-212/288.0
QNLHKNRFSDIIALNSCRVMLHkehaDEESDYINAVFLHAHRGRNAFIATQHPLLETVEDFWRMVTDYDIGTIVMLNNLHDQVAPESSEYWPDHG--ATK
.|  ..|. ..   . .|| |.    |.   ||.|  . ... .. .| .| ||  |.| .|.|. . |.  ||||..| ..  ..| ||.| .   ...
anptrdryenlprcditrvkls....ddpdfyiaanvvssakykrrlicaqaPlngtieelWkmllesdveyivmlcellekGkeksaeyfPsklGekar

YGHIGISVLSKQKKGDVICV--KPKVTRKKKTHE-VRHLHHVSWTDKCIPKVSRSVLDLLDEVQTSQQqcgnvPVLVQCR
.|..   |  |..  | . .    ..... ...  |..||   | |...|.   | | ||. ... |.     |..|...
igrlctvvkkkradidklvkvsllriskegeekvivkilhlleWdddgvPenylsplrllevlkslqk.....Pivvhss
0049772 (Phosphotyrosine protein) phosphatases II 444-623 4.2e-22 74.7 In-house 40-220 (314) alignment 
Range on Protein: 444-623
Range on HMM: 40-220/314.0
VGEKPQNLHKNRFSDIIALNsCRVMLHKEHADEeSDYINAVFLHAHrgrNAFIATQHPLLETVEDF----------WRMV--TDYDIGTIVM--------
|. .. | .|||. ||.  . .||.|.... .  |||||| ... .   ..|||||.|| .||.||          ||||   |... .|||        
vadlflnrdknryldilpad.nrvilpglpvsg.sdyinasyvdgf...lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivmsrdevlad

-------------LNNLHDQVapesseywpdhgaT---------KYghigisvlskqkkgdvicvkpKVT--RKKKTHEVRHLHHVSWTDKCIPkVSRSV
             |..|  .                                               ...  ... .... ..... ..| . |  .. .
elsrLdaAlgKtpllildgng.............neptaadlellk.....................eelydpelferlgikylripvpDgsap.lledf

LDLLDEVQTSqqqCGNVPVLVQCR
...|. ...      . |||| |.
deflefieea...dkggpvlvHCk
subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 401-565 5.3e-22 72.8 In-house 8-167 (310) alignment 
Range on Protein: 401-565
Range on HMM: 8-167/310.0
EKYNQAMQKLASVNGKFPMTGYALEFQRLNSVTSREIPVEEksvgeKPQNLHKNRFSDIIALNSCRVMLHKEHADeESDYINAVFLHAHRGRNAFIATQH
 || .|....     |. . | . ....|..     .  |        ...||||.||.. |...|| |. ...    ||| | ....   |..|| .| 
lkylkalenfiiateklgieglvkqyrkldakqdssltyea.....ykkymhknrysdvvcldtsrvklkidksr.yedyihanyvktnylrstficsqg

PLLETVEDFWRMVTDYDIGTIVMLNNLHDQVAPESSEYWPDHGATK-YGHIGISVLSKQKKGDVIC
||  |. |||||. .    .|..| .  ..  | .  |||  | |. || | .. ||.  .   ||
plqhtiidfwrmifqeraesilllckvgeegrpkcvgywpslgvtetygcirvtnlsesseefeic
0043147 (Phosphotyrosine protein) phosphatases II 475-623 6.7e-22 73.4 In-house 2-108 (172) alignment 
Range on Protein: 475-623
Range on HMM: 2-108/172.0
DEESDYINAVFLHAHRGRNAFIATQHPLLETVEDFWRMVTDYDIGTIVMLNNLhdqvapesseywpdhgatkyghigisvlskqkkgdvicvkpKVTRKK
|| |||||| .|. ..  . ||||| || .|..|||||. ...|..||.|..|                                          .....
degsdyinasyldlyyipdrfiatqgplrntladfwrmlkelgithivnltel.........................................lydpel

KTHEVRHLHHVSWTDKCIPkVSRSVLDLLDEVQTSQQQCGNVPVLVQCR
 .... ......| | . |  .. .|..|. ... .... . |||| |.
lerlgiqylylpwpDhgvp.llellleflefidellalspggpvlVHCs
subfamily_ptpA1_pd Subfamily ptpA1 439-622 1.2e-21 72.0 In-house 36-236 (418) alignment 
Range on Protein: 439-622
Range on HMM: 36-236/418.0
VEEKSVGEKPQNLHKNRFSDIIALNSCRVMLHKEHADEESDYINAVFLHAHRGRnAFIATQHPLLETVEDFWRMVTDYDIGTIVMLNNLHDQVAPESSEY
  | | |.| .|  |||...|. .|  || |.| .  | |||||| ..     .  ||.|| || .|. |||||| .     ||||.   ...  .   |
psetsegdkkhntsknrytnilpvnhtrvqlkkiqdkegsdyinanyidgaypk.qfictqgplpntiadfwrmvwenrcriivmlsresencrikcdry

WPDH-GAT----------KYGHIGISVL--SKQKKGDVICVKPKVTRKKKTHEVRHLHHVSWTDKCIPKVSRSVLDLLDEVQTSQQQC-----GNVPVLV
||.. |             .|   . ..   .. . ..|  . ..| . .|... . ..  | |. ||  .. . .||  .   |.|       |||..|
wpeqiggeqfsiygngnevfgtysvelveviqdpereiitrnirltfegetrditqyqyegwpdhnipdhtqpfrqllhsitnrqnqiipssdrnvpiiv

QC
.|
hc
0036282 (Phosphotyrosine protein) phosphatases II 478-624 2.2e-21 71.8 In-house 2-113 (174) alignment 
Range on Protein: 478-624
Range on HMM: 2-113/174.0
SDYINAVFLHAHRGRNAFIATQHPLLetvedFWRMVTDYDIGTIVMLNNLHDQVAPESSEYWPDhgatkyghigisvlskqkkgdvicvkpkvTRKKKTH
|||||| .|. ..  . .||.|.||      ||.|. ...| |.|||....         |||.                             .|.  ..
sdyinaspldlsyitprliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe.............................lredler

EVRHLHHVSWTDKCIPKVSRsVLDLLDEVQTSQQQCGNVPVLVQCRY
.. ..... | | . | .|  .|.....|.. ...... |||| |. 
lgiqylylpwpDhgvpdlsi.llefvkfveealsedpggpvlVHCsa
0051429 (Phosphotyrosine protein) phosphatases II 478-623 5.1e-21 71.0 In-house 4-158 (272) alignment 
Range on Protein: 478-623
Range on HMM: 4-158/272.0
SDYINAVFLHAHRG---RNAFIATQHPLLETVEDFWRMvTDYDIGTIVMLNNLHDQVAPESSEYWP------------DHGATKYGHIGISVLSKQKKGD
|.|||| ..    .   .........||  |..||||.  ...| |||.| ... . .   . |||            ..    ||.. . .||.. . |
sgyiNardvggygrvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseellld

VICVKPKVT---RKKKTHEVRHLHHVSWTDKCIPKvsRSVLDLLDEVQTsqqqcgNVPVLVQCR
.|. .  .|     ....||.|||. .| | ..|.   ..|.||.....      . |||| |.
yilrellltlllsagearevmhlhytdwpdhgvpq..eallellellld......ggpvlvHCs
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 159-277 1.1e-20 68.6 In-house 48-178 (350) alignment 
Range on Protein: 159-277
Range on HMM: 48-178/350.0
KNKNRYANIVAYDHSRVVLER--------VNGDEDLDYINASFIHGY----DGTPRS-FIASQGPLPPAFEGFWRMVWEQNSQSIVMLTNLVGLNKTKCH
  |||| ||. |.|||| |..            .  |||||....      .  |   .|| |.||| ... |.... . . . |..||..| ||  ||.
faknrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvkvilsltsdvelnlekcy

KYWPDKteTYGGVTVTLHQ-SEVFAGYENCTFI
.||..   .| ..|| | .  |  .| ....  
rYWqeg..sydditvklaskwenimgindssly
subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 156-388 2.1e-20 67.3 In-house 49-282 (302) alignment 
Range on Protein: 156-388
Range on HMM: 49-282/302.0
NKNKNKNRYANIVAYDHSRVVLERvngdEDLDYINASFIHGYDGTpRSFIASQGPLPP---AFEGFWRMVWEQNSQSIVMLTNLVGLNKtKCHKYWPDKT
 || .||.  .. ..|. .| ||     |  .|.||| ..  . | || | .| |      . | |||||.... .|.|.|     |.|   ....| |.
kknlkknqsedvpildsnlvklea....epdsyvnaskvevPelt.rsiilaQlpkvdsedsveeFWrmvfqekivsvvilvgeeelkk.tlselfpkks

ET---YGGVTVTLHQSEVFAGYE-NCTFILSKEKRSGSRIVRQFHFTVWPDKGVPQYATAVLAFRRKVRALNPRDAGPVIVHCSVGVERTGAYIVIDAML
..   || . |   . |   . . . .  .  |  | | ..   ..| |..| ||.  ... .   || |..     ....    |. | || ..  . .
gdykeygkmfvNnrkVekaeeektryviEvlPegcsnsvlanvyvltnWkqkkvpvkyaeliktaakvfakkikadentvivSknGaGRagafltlavav

EQAKKSRTVDIRNYLIAIRKHRPHMVQTKEQYSFIHSAVL
|. .|.  . | . ...||. ||..|.. .|| ... |.|
eklqkgkepnikeivksiRsqRpravdslkQyvslyiall
subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 202-384 4.7e-20 66.6 In-house 5-197 (199) alignment 
Range on Protein: 202-384
Range on HMM: 5-197/199.0
RSFIASQGPLPPAFEGFWRMVWEQNSQSIVMLTNLVGLNKTKCHKYWPD---KTETYGGVTVTLHQSEVFAGYENCTFILSKEKR--SGSRIVRQFHFTV
| .||.| ||  ..  ||.||||  |  |||. .    ...    |||     |  || ..|| .   . . |  ...||...      .| . .. || 
rryiatqhplretmadfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqfts

WPDKGVPQYAT---AVLAFRRKVRALNPRDAGPVIVHCSVGVERTGAYIVIDAMLEQAKKSRT--VDIRNYLIAIRKHRPHMVQTKEQYSFIH
| .|  |. |     |.| |   .  .     ||||||| |   || .. .|  .   ..|.|  ||. .    .|. |  .. . ..| ||.
wkekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiy
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 425-623 4.7e-20 66.7 In-house 11-200 (267) alignment 
Range on Protein: 425-623
Range on HMM: 11-200/267.0
EFQRLNSVTSREIPVeEKSVGEKPQnlHKNRFSDIIALNSCRVMLHKEHADeesdYINAVFLHAHRGRNAFIATQHPLLETVEDFWRMVTDYDIGTIVML
||. .. ... .  .  .|..|| |   .||. | .  .  ||.| ..  .    |||| ...... .||||.|| ||  |. ||. ...|... .||.|
efelikkisdtssti.sqsiaeknq..ernrlddnlpyddtrvilrtkeee....yinasyvegyktknafivtqdplkntitdfltvihdqkvpvivll

NNLHdqvAPESSEYWPDH--GATKYGHIGISVLSKQKKG--DVICVKPKVtRKKKTHEVRHLHHVSWTDKCIPKVsrSVLDLLDEVQTSQQQCGNVPVLV
 .       .   .|| .   | ||  . .    ....   ..| .. |. ... .|.|   ..  |  .   |    .  |.  .   | . || |..|
tkvf...tdnirlfwPPkmgqakkyqdltvehslekeendyqiitlelkf.knesahnvtlyyykkwnintnnkp..ylkplfgilaknqlengnrPlvv

QCR
.| 
acs
subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 202-384 5e-20 66.5 In-house 4-196 (198) alignment 
Range on Protein: 202-384
Range on HMM: 4-196/198.0
RSFIASQGPLPPAFEGFWRMVWEQNSQSIVMLTNLVGLNKTKCHKYWPD---KTETYGGVTVTLHQSEVFAGYENCTFILSKEKR--SGSRIVRQFHFTV
| .||.| ||  ..  ||.||||  |  |||. .    ...    |||     |  || ..|| .   . . |  ...||...      .| . .. || 
rryiatqhplretladfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqfts

WPDKGVPQYAT---AVLAFRRKVRALNPRDAGPVIVHCSVGVERTGAYIVIDAMLEQAKKSRT--VDIRNYLIAIRKHRPHMVQTKEQYSFIH
| .|  |. |     |.| |   .  .     ||||||| |   || .. .|  .   ..|.|  ||. .    .|. |  .. . ..| ||.
wkekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiy
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 426-622 4.8e-19 63.5 In-house 22-216 (307) alignment 
Range on Protein: 426-622
Range on HMM: 22-216/307.0
FQRLNSVTSREIPVEEKSvgekpQNLHKNRFSDIIALNSCRVMLHKEHAdeESDYINAVFLHAHRGRNAFIATQHPLLETVEDFWRMVTDYDIGTIVMLN
|. |   |   ..||  |      | .|||..|. . . .|.... . .   |||| | .|      . ||..| || .|. .|| |. . .. ...|| 
frvlakktpegvtveafs.....antdknryqdvkcqdkgrivvkfdgl..asdyihanylgiaikpkkficaqgplentqysfwamaiqekvesvimlc

NLHDQVAPESSEYWPDHGATK--YGH----IGISVLSKQK---KGDVICV-KPKVTRKKKTHEVRHLHHVSWTDKCIPKVSRSVLDLLDEVQTSQQqcgn
.. .       .|||     |  .|.    | .. |  .|     |.| | . ||   .|.  ..||    | |. .|..  . ..||. |.  .     
kvielakikceqywpleegqklvfgeapntisvanlgakklapdedlinvttlkvdwaqksrtiqhlqwenwpdrgvpqinltainlleavrydtn....

vPVLVQC
 ||.| |
.pvvvhc
0046846 (Phosphotyrosine protein) phosphatases II 471-623 2.9e-18 61.7 In-house 5-117 (176) alignment 
Range on Protein: 471-623
Range on HMM: 5-117/176.0
KEHADEESDYINAVFLHAHRgrnaFIATQHPLLETVEDFWRMVTDYDIGTIVMLNNLHDQVAPESSEYWPDhgATKYGHigisvlskqkkgdvicvkpkv
. . |. .||||| ..  .|    .||||.|| .|..||..|. ...|...|.|.....        |||.   .|.|.                     
llgldldldyinanlilgsr....piatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpe..leklgi.....................

trkkkthevrHLHHVSWTDKCIPKVsRSVLDLLDEVQTSQQQcgNVPVLVQCR
          . .|. | | ..|   . .|.||..... ...  . |||| |.
..........qylhlpwpDhgvpdl.elllellefirealke..ggpvlVHCs
subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 436-608 8.9e-18 58.9 In-house 23-198 (281) alignment 
Range on Protein: 436-608
Range on HMM: 23-198/281.0
EIPVEEKSVGEKPQNLHKNRFSDIIALNSCRVMLHK-EHADEESDYINAVFLHAHRGRNAFIATQHPLLETVEDFWRMVTDYDIGTIVMLNNLHDQVAPE
. | .  .| ..| | .|||...| .|.  || |.      . .||| | ....   .  .| || |  ||  |||||. . .  .|||| .. .    .
dppsdlctvfnqpvnnkknrylnipcldisrvqlkvkmpnknstdyihanyirspflkrgyiltqgpkketradfwrmiwqenttaivmlcqfletnrek

SSEYWPD--HGATKYGHIGISVLSKQKKGDVICVKPKVTRKKKTHEVRHLHHVSWTDKCIPKVSRSVLDLLDEVQT
 .||.|   | . .. .. .|      .  ..  . ... . .|. . |     | |  .|. |  .| .| ....
caeyfprnahcclqfdklsvsyedstvnkslvttrlnlsyegetrlithwlwkewpdwqvpessevmlkilrkira
subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 157-408 9.3e-18 59.4 In-house 18-277 (290) alignment 
Range on Protein: 157-408
Range on HMM: 18-277/290.0
KNKNKNRYANIVAyDHSRVVLERVNGDEDLDYINASFIHGYDGTprSFIASQGPLPPA-------FEGFWRMVWEQNSQSIVMLTNLVGLNKT----KCH
|.. ..|... ..  ..||||.        ||| |...   .|    .|..| |.           | || |. . .....||| .    ..      | 
khemdqRlevpLv.eatrvvLkgygkrfnddyiHAnrvtcpngl..rliltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCa

KYWPDKTE---TYGGVTVTLHQSEVFAGYENCTFILSKEKRSGSRIvRQFHFTVWPDKGVPQYATAVLAFRRKVRalnpRDAGPVIVHCSVGVERTGAYI
|| |.. .   ...|.||   . |   . |. . ..  ...    .     .  | .  |..    .|.  .||.        ||||||  |. |  |  
kYvpesvgeelkfkgltvkCkskekeddvetRelvvkfddeeeftv.tHsllkgWnklnvqedtktllsliqkvk....asktpvivHcvdGiSrsAala

VIDAMLE-QAKKSRTVDIRNYLIAIRKHRPHMVQTKEQYSFIHSAV-LEALTCGNTEIQSEKYNQAMQ
 |.      |..|  | ... | |.||.| ..........|.  .. | |   ... ...|. ..|..
aiilgyQkiaetsgsvkledvlkalrkqralaitsalelafvdagivllaievldqfaeeetekkaka
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 435-546 1.3e-17 58.6 In-house 32-157 (350) alignment 
Range on Protein: 435-546
Range on HMM: 32-157/350.0
REIPVEEKSVGEKPQNLHKNRFSDIIALNSCRVMLH--------KEHADEESDYINAVFLHAH----RGRNAF--IATQHPLLETVEDFWRMVTDYDIGT
 | | ..  . |  .   |||...|.  .  || |.        |.|. . .||||| .|.      .    |  |||| || .||.||.....  ..  
sespsnDvilseGvelfaknrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvkv

IVMLNNLHDQVAPESSEYWPDHGATK
|..|... ..      .||.. .  .
ilsltsdvelnlekcyrYWqegsydd
subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 214-391 1.4e-17 58.7 In-house 40-221 (255) alignment 
Range on Protein: 214-391
Range on HMM: 40-221/255.0
AFEGFWRMVWEQNSQSIVMLTNLVGLNKTKCHKYWP---DKTETYGGVTVTL--HQSEVFAGYENCTFILSKEKRsgSRIVRQFHFTVWPDKGVPQYATA
. . |....  .... .|||...   .. ||..|.|   |.   .  |.||     ..|     . |  |.. |.   . |. .... |..|  |. |  
tvdkfyqtivqtktevvvmlcdfaeegvekcssyfplekdeklkladvnvtttkssadvvlrtleitstlgekkk..thtvkhysykGWieknaPelare

VLAFRRKVRalnprDAGPVIVHCSVGVERTGAYIVIDAM----LEQAKKSRTVDI--RNYLIAIRKHRPHMVQTKEQYSFIHSAVLEAL
.|   . ||     |. .|.|||| |. |. |..... .    . . ... ||..  .. |  .|..|.  ..|  | .|    ||. .
ilnilkvvr.....dsksvvvhCstGiGrsaafvlaelvyqkmirsldttetveldylslleelrskrkraihtPlqlafsilmvldlv
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 447-611 1.7e-17 58.1 In-house 45-220 (305) alignment 
Range on Protein: 447-611
Range on HMM: 45-220/305.0
KPQNLHKNRFSDIIALNSCRVMLHKEHAdeeSDYINAVFLHAHRGRNAFIATQHPLLETVEDFWRMVTDYDIGTIVMLNNLHDQVAPESSEYWPDHG--A
. |. .|||. |.  |.  || |.        .|| | .. .    . || || || .|  ||| |  .  . .| || || .. |   .||.. .    
eaqeagknrykdvgcldnnrvklegpwp...heyihanyvstptnpkrfictqaplektcadfwymclqdkveaifmlcnllekgakkcleyfaskdkdv

TKYGHIGISVLSKQKKGDVIC----VKPKVTR--------KKKTHEVRHLHHVSWTDKCIPKVSRSVLDLLDEVQTSQQ
 ..   |  .  | .    .      | |||.         .|.. | | | . | |. .|    ..|.|| . ..|. 
lefeekgqkisvkfessvtlkfrkdakakvtetvlviegpgekarkvthyhwidwpdrgvpaadlailellekarpskg
subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 489-623 1.8e-17 58.2 In-house 1-143 (199) alignment 
Range on Protein: 489-623
Range on HMM: 1-143/199.0
HRGRNAFIATQHPLLETVEDFWRMVTDYDIGTIVMLNNLHDQVAPESSEYWP--DHGATKYGHIGISVLSKQKKGDVI----CVKPKVTRKKKTHEVRHL
|.|.  .||||||| ||. |||.|| .   | |||.|.   .   . . |||  . |..||| . ... .   | |       .  ..|    | |. | 
hkgqrryiatqhplretmadfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishy

HHVSWTDKCIPKVSRSVLDLL--DEVQTSQQQCGNVPVLVQCR
   || .|  |.|.  |  ..   ||    .|  . ||.|.| 
qftswkekttpnvalfvgfvvasrevskkyeqekdapvivhcs
subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 481-622 1.9e-17 58.0 In-house 78-221 (301) alignment 
Range on Protein: 481-622
Range on HMM: 78-221/301.0
INAVFLHAHRGRNAFIATQHPLLETVEDFWRMVTDYDIGTIVMLNNLHDQVAPESSEYWPDHGATK--YGHIGISVLSKQK------KGDVICVKpKVTR
| | .. ..   . ||||| || .| |||| |.. ||. .|||| .  ..     .|| | . . |   |   | . .|..      .   . |.   |.
ihanwiptsGhphrfiatqgPlkntsedfwamlvqydvekivmlgqkvekleekceeylpvkisekldigrfkikiknkelilnkkiskrtleve.dstg

KKKTHEVRHLHHVSWTDKCIPKVSRSVLDLLDEVQTSQQqcgnvPVLVQC
| .|. | |  ...|||. .||    . ||.. |. |..     |..|.|
kfatrtvthyqysewtdrgvPkshaelfdlmelvkksek.....Pivvhc
subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 491-623 6.9e-17 56.3 In-house 2-142 (198) alignment 
Range on Protein: 491-623
Range on HMM: 2-142/198.0
GRNAFIATQHPLLETVEDFWRMVTDYDIGTIVMLNNLHDQVAPESSEYWP--DHGATKYGHIGISVLSKQKKGDVI----CVKPKVTRKKKTHEVRHLHH
|.  .||||||| ||. |||.|| .   | |||.|.   .   . . |||  . |..||| . ... .   | |       .  ..|    | |. |   
gqrryiatqhplretladfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqf

VSWTDKCIPKVSRSVLDLL--DEVQTSQQQCGNVPVLVQCR
 || .|  |.|.  |  ..   ||    .|  . ||.|.| 
tswkekttpnvalfvgfvvasrevskkyeqekdapvivhcs
subfamily_CG42327_pd Subfamily CG42327 451-609 8.1e-17 55.9 In-house 29-193 (319) alignment 
Range on Protein: 451-609
Range on HMM: 29-193/319.0
LHKNRFSDIIALNSCRVMLHKEHADEESDYINAVFLHAHR-GRNAFIATQHPLLETVEDFWRMVTDYDIGTIVMLNNLHDQVAPESSEYWPDH----GAT
  |.|. ... |   ||.|..   |... |..| ..  ..  .| .||.| .| ..  ||||.| .    .|| | .|...     .||.| .    .  
kdksrvinvvPlPetrvvlqrigdddkdeyldasyvrGyddapnsyiaaqvsledsssdfwrtvweqqsrvivqltdlselGikvcaeylPtketldnts

KYGHIGISvLSKQKKGDVICVKPKVTRKKKTHEVRHLHHV--SWTDKCIPKVSRSVLDLLDEVQTS
 ||.| .. | ... .|   .   . .. . .| |.| |    | .  .|   .... .| ||..|
lyGdilvt.lkgrevkdryaistlllkrvdkeesrelthywykwleaevPaeeaaliamllevrss
0049260 (Phosphotyrosine protein) phosphatases II 489-624 2.7e-16 55.1 In-house 5-98 (152) alignment 
Range on Protein: 489-624
Range on HMM: 5-98/152.0
HRGRNAFIATQHPLLETVEDFWRMVTDYDIGTIVMLNNLHDQVAPESSEYWpdhgatkyghigisvlskqkkgdvicvkpkvtrkkkthevrHLHHVSWT
..  ..|||||.|. .|..|||||. ...|.|||||..|..   .   .|.                                         . .|. | 
yampfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi.........................................qylhlpwp

DKCIPKVSRSVLDLLDEVQTSqQQCGNVPVLVQCRY
| . |. |  .|.||. ..   ..  . |||| |..
Dhgvpdlsqlllflllfiekl.aldkggpvlVHCsa
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 450-622 4.7e-16 53.3 In-house 55-228 (305) alignment 
Range on Protein: 450-622
Range on HMM: 55-228/305.0
NLHKNRFSDIIALNSCRVMLHKEHadeESDYINAVFLHAHR-GRNAFIATQHPLLETVEDFWRMVTDYDIGTIVMLNNLHDQVAPESSEYWPDHGATK-Y
.  |||..|. . .   | |.|      |||| | .. .     . ||..| || .|...|| || .  .  |||| .  .      ..|||     |  
aitknryqdvpcqdqsavkldkps...psdyihanyvgcpmipekrficaqgpldqtidefwwmviqnkveqivmlcktvelgklkcaqywpaaqgekle

GHIGISV--LSKQK----KGDVICVKPKVTR-KKKTHEVRHLHHVSWTDKCIPKVSRSVLDLLDEVQTSQqqcgnVPVLVQC
 . || |  .|  |      ..     ..|   ...  ||||.   | |. .| .  . |.||  .. |.     ||..|.|
lksgivvenvsgskpmerdaeiqitllnltysgdqkmsvrhlqwtewpdrgvppckltslellsairgsk.....vpivvhc
subfamily_hpo-7_pd Subfamily hpo-7 214-404 1.2e-15 52.1 In-house 46-241 (263) alignment 
Range on Protein: 214-404
Range on HMM: 46-241/263.0
AFEGFWRMVWEQNSQSIVMLTNLVGLNKTKCHKYWP---DKTETYGGVTV--TLHQSEVFAGYENCTFILSKeKRSgSRIVRQFHFTVWPDKGVPQYATA
. . |....  .... .|||..    .. || .|.|   |.   .  |.|  |  ||.|    .. . .|.. |.   . |... .. |..|  |. |  
tidkfyqtivqtktevvvmLcDfneegvekcssyfPlekdekqklanvnvcttkvqsdvllktlellstlge.Kkk.thtvkhysykgWiekndpelare

VLAFRRKVRalnprDAGPVIVHCSVGVERTGAYIVIDA----MLEQAKKSRTVDI--RNYLIAIRKHRPHMVQTKEQYSFIHSAVLEALTCGNTEIQSE-
.|   . .|     .  ...|||| |. |. |. |..     |. . ... ||..  .. |  .|..|.  ..|  | .|    ||. .   ... . | 
ilnilkvar.....nskslvvhcstGiGrsaafsvaElvyqkmirsldttstveldylsLleelrssrkraihtPmqLafsilmvLdfvlnnfakgelea

KYN
||.
kyq
subfamily_CG42327_pd Subfamily CG42327 322-386 1.2e-15 52.0 In-house 245-310 (319) alignment 
Range on Protein: 322-386
Range on HMM: 245-310/319.0
RDAGPVIVHCSVGVERTGAYIVIDAMLEQAKKS-RTVDIRNYLIAIRKHRPHMVQTKEQYSFIHSA
 . ||..|||| || |||  |  |  ... ..| |.||| . .  .|. | . |.||||| ||.  
esqGPlvvhcsdGvGrtGlviasdiairsleeskrsvdiPqlvssvrrdrasavltkeqyefiykv
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 314-391 1.6e-15 51.7 In-house 219-295 (297) alignment 
Range on Protein: 314-391
Range on HMM: 219-295/297.0
RKVRALNPRDAgPVIVHCSVGVERTGAYIVIDAMLEQAKKSRTVDIRNYLIAIRKHRPHMVQTKEQYSFIHSAVLEAL
  .||  ||.| ...|||| || |.|  .  |..|.. .| |  |..  |  .|. |. .||| ||. ....|||. |
eslraemprna.yllvhcsaGvGrsGvvvlsdvilaklrkkripdvaailsilreqrarlvqtleqfellydavlkkl
subfamily_Sponge-PTP-7_pd Subfamily Sponge-PTP-7 328-394 2e-15 50.9 In-house 2-68 (69) alignment 
Range on Protein: 328-394
Range on HMM: 2-68/69.0
IVHCSVGVERTGAYIVIDAMLEQAKKSRTVDIRNYLIAIRKHRPHMVQTKEQYSFIHSAVLEALTCG
.|||| |  |||..| |   . . |  . ||| | .  .|| || ||  . .| ||| |. |||  |
vvhcssgtgrtgtfiaimvemarikseklvdifnnvqymrkcrpmmvmneieyifihdalvealklG
subfamily_egg_pd Subfamily egg 447-595 2.3e-15 51.1 In-house 37-187 (307) alignment 
Range on Protein: 447-595
Range on HMM: 37-187/307.0
KPQNLHKNRFSDIIALNSCRVMLHKEHADEESDYINAVFLHAHRGRNAFIATQHPLLETVEDFWRMVTDYDIGTIVMLNNLHDQvaPESSEYWPDHG--A
.  ||.| |   .   .|.|| |. ..     |.| |  .. .   | || .| || .||.||||||   ..  ||||.   .    .   |||     .
sdnnlekarskrvhckdssrvklelrrGqylddfihanrvkGkpllnefilaqaplkntvddfwrmvfqeevqyivmltsrkes..erceyywpkaesds

TK--YGHIGISVLSKQKKGDVICVKPKVTRKKKTHEVRHLHHVSWTDKCIPKV
 .   | . |  |  ..| | .    |.      .| |.| |  .  .   .|
lvtvpGslrienlkvdskadplfrvtklklvGgddeerflehwqgdvnnssdv
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 113-198 2.8e-15 50.6 In-house 4-87 (440) alignment 
Range on Protein: 113-198
Range on HMM: 4-87/440.0
KPIPIALFPEYVAKMHGGIRLETEYKKFNNGQQFPWGAARKPANknKNKNRYANIVAYDHSRVVLERVNGDEDLDYINASFIHGYD
.|| .| | .|| . .     | |.  . .| . |   |  | |  | |||| ||.|||||||.|| |.|  | ||||||.| | .
rpiivadfadyvqnnrrsrafedewsllpsglsqpsdiaslpnn..kvknryrnilaydhsrvmleevkgvpdsdyinasyingie
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 492-551 3.4e-15 50.3 In-house 235-292 (440) alignment 
Range on Protein: 492-551
Range on HMM: 235-292/440.0
RNAFIATQHPLLETVEDFWRMVTDYDIGTIVMLNNLHDQVapeSSEYWPDHG-ATKYGHIG
.||||||| ||  || ||||.| || | ||.|||.| |.     | |||    .  .| . 
knafiatqmpldstvldfwrlvhdyristiimlnqlndkt...csiywpvntrsvtfgpft
subfamily_Sponge-PTP7_pd Subfamily Sponge-PTP7 328-394 3.9e-15 50.0 In-house 1-67 (69) alignment 
Range on Protein: 328-394
Range on HMM: 1-67/69.0
IVHCSVGVERTGAYIVIDAMLEQAKKSRTVDIRNYLIAIRKHRPHMVQTKEQYSFIHSAVLEALTCG
.|||| |  |||..| |   . . |  . ||| | .  .|| || ||  ...| ||| |. |||  |
vvhcssGtGrtGtfiaimvemarikseklvdifnnvqymrkcrpmmvmneneymfihdalvealklG
subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 214-391 5.2e-15 49.7 In-house 103-288 (302) alignment 
Range on Protein: 214-391
Range on HMM: 103-288/302.0
AFEGFWRMVWEQNSQSIVMLTNLVGLNKTKCHKYWPDKTE---TYGGVTVT---LHQ-SEVFAGYENC-----TFILSKEKRSGSRIVRQFHFTVWPDKG
. | .| .. . |   .| |...|  .. || .|. || .   ..|  ||.   ...  | |.  ..       .  .| |.   . |  ..|. |||.|
tlekhwalieqynvaivvqlcsfvedeekkcaeyysdkvggelkfgrytvktvsvktdleeftdkksfklytveiknekkkkkvkktvdilafsawpdhG

VPQYATAVLAFRRKVRALNPRdagpVIVHCSVGVERTGAYIVIDAMLEQAKKSRTVDIRNYLIAIRKHRPHMVQTKEQYSFIHSAVLEAL
 |. | . |   .   .        |.||||.|| |||. . |   ..  .| .. |. . .. .|. |   ||...|  ..   |  .|
apkeaytaldilkfcesykkn....vlvhcsaGvGrtGtlvaikyGiqlcskkkvtdllsivlpvrqcryGavqdeqqliylllcvtkgl
subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 152-391 1.2e-14 48.6 In-house 41-279 (303) alignment 
Range on Protein: 152-391
Range on HMM: 41-279/303.0
RKPANKNKNKNRYANIVAYDHSRVVLErvngdeDLDYINASFIHgYDgTPRSFIASQGPLPPAFEGFWRMVWEQNSQSIVMLTNLVGLNKTKCHKYWPDK
..   || .|||.....  |||.| |       |  || ||...  | . .  | .| ||. .   ||.|. ||. . ...|      .|   .  .| .
knqfvknmdknrfvdvicldhskvkls......dssyihasyle.ld.sskkailtqlplshtaadfwqmiieqkvkcvlllltdseydklggdsvfprn

TETYG----GVT-VTLHQSEVFAGYENCtfILSKEKRSGSRIVRQFHFTVWPDKGVPQY-----ATAVLAFRRKVRALNprDAGPVIVHCSVGVERTGAY
 .        .    ... |.  |.     .||  . .   ..   |.  || . .|          .   .  .|     |. | .     |. |.|..
qdflkfeersirvgefkrvelgdgwvlk..vlsvsngdyksflhvhhykawphnsipsdgspkfvkqiwqlqsvlrkys..dstptvymslsgcgragtf

IVID-AMLEQAKKSRTVDIRNYLIAIRKHRPHMVQTKEQYSFIHSAVLEAL
 ... | |   ..  ..|. . |  .|. | | ||   |.|.... . | .
alfetahlslhseqasldlvkclenvrngrlhavqnlsqfsvvytllaehv
subfamily_eak_pd Subfamily eak 158-316 2.4e-14 47.5 In-house 52-207 (332) alignment 
Range on Protein: 158-316
Range on HMM: 52-207/332.0
NKNKNrYANIVAYDHSRVVLERVNGDeDLDYINASFIHgYDGTPRSFIASQGPLPPAFEGFWRMVWEQNSQSIVMLTNLVGLNKTKCHKYWPDKT---ET
. |.|   .|| ||.  | |     .  | ||||| .  .    | .| .  .       ||.|| ||.| .||.| . | |.  |  ||.||||     
avnrn.vvkivpydrylvrltssqln.rlGyinaslae.fsevGrkyiltGiasedkvfafwqmvleqkspaivqlledvelkleksdkyfpdktreelk

YGGVTVTLHQSEVFAGYENCTFILSKEKRsgSRIVRQFHFTVWPDKGVPQYAtAVLAFRRKV
.| . |.  .    . .|   ..|||     .  |  ...  | .  .|.|    ||.|. .
fGildverkefvkrniletrllelskGne..thrvlhykvfGwtettlpkye.dflalrkvm
subfamily_eak_pd Subfamily eak 435-596 3.2e-14 47.1 In-house 37-198 (332) alignment 
Range on Protein: 435-596
Range on HMM: 37-198/332.0
REIPVEEKSVGEKPQNLHKNrFSDIIALNSCRVMLHKEHADeESDYINAVFLHAHRGRNAFIATQHPLLETVEDFWRMVTDYDIGTIVMLNNLHDQVAPE
.  ..  .|.... .....|   .|.  .   | |     . .  ||||  .      . .| |  .  . |  ||.|| .    .||.| .  ..   .
dyqrllsisetarleavnrn.vvkivpydrylvrltssqln.rlGyinaslaefsevGrkyiltGiasedkvfafwqmvleqkspaivqlledvelklek

SSEYWPDHG--ATKYGHIGISVLSKQKKGDVICVKPKVTRKKKTHEVRHLHHVSWTDKCIPKVS
|  |.||..    |.|.. .   .  |.. .   . ....  .||.| | .   ||.  .||. 
sdkyfpdktreelkfGildverkefvkrniletrllelskGnethrvlhykvfGwtettlpkye
0051082 (Phosphotyrosine protein) phosphatases II 478-624 1.1e-13 46.6 In-house 3-101 (151) alignment 
Range on Protein: 478-624
Range on HMM: 3-101/151.0
SDYINAVFLHAHrgrnaFIATQHPlletVEDFWRMVTDYDIGTIVMLNNLHDQVapESSEYWPDHGatkyghigisvlskqkkgdvicvkpkvtrkkktH
|||||. ..  .     ......|     .||.... ...| |||.|....        ||.|..|                                 .
sdyinfsyvtgg.....lyrsggp....ladflellkelgiktivnlrseeerg..ycpeylpelg.................................i

EVRHLHHVSWTDKCIPKVSRSVLDLLDEVQTsqqqCGNVPVLVQCRY
||.|.. ..|.|  .|    .||..|....     ..| |||| |. 
evlhipildwpdpglplsfdavleflellld....kkngpvlvHCsa
subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 450-622 1.4e-13 45.4 In-house 35-210 (285) alignment 
Range on Protein: 450-622
Range on HMM: 35-210/285.0
NLHKNRFSDIIALNSCRVMLhKEHadeESDYINAVFLHA-HRGRNAFIATQHPLLETVEDFWRMVTDYDIGTIVMLNNLHDQVAPESSEYWPDHG--ATK
|   ||..|. ...  ||.| |.|   . ||| | ...   . ....|.|| || ||. |||.|. .  |  ..||  | .    . . |.|..     |
npdlnryadvrcieetrvvl.knh...drdyihaswmrmpgkdqstyittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekcalyypeklgevvk

YGHIGISVLSKQKK---GDVICVKPKVTRKKKTHEVRHLHHV---SWTDKCIPKVSRSVLDLLDEVQTSQQQcgNVPVLVQC
.|.  |..   ...   | ..     .  .  . |  .. ||    | |.  |. .| ...|   |.  . .  . |. |.|
fgkyeitlteckeeaiagtilnaltvintedasseplymnhvqvpwwpdqlapedarpmielykwvkkvnpk..ekpicvhc
0044763 (Phosphotyrosine protein) phosphatases II 464-623 4.5e-13 44.7 In-house 4-118 (178) alignment 
Range on Protein: 464-623
Range on HMM: 4-118/178.0
SCRVMLHKEHADEESDYINAVFLHAHrgrnaFIATQHPLletvEDFWRMVTDYDIGTIVMLNNLHDQVAPESSEYWPDHGAtkyghigisvlskqkkgdv
 .|| |..    | ||||||..   .     ......|     .|..... ...|..||.|..      ... .|||.                      
rtrvllsnleglersdyinaseilpg.....lylgslpp....addlellkelgithivnlteelelgflkcdpywpeeag...................

icvkpkvtrkkkthevRHLHHVSWTDKCIPKVSRSVLDLLDEVQTSQQQCGNvPVLVQCR
                 . .|. . | . | ... .|.... ... ....|. |||| |.
................iqylhipipDhgvpdllehflefvefieealdekgg.pvlVHCs
subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 446-547 8e-13 42.6 In-house 92-186 (244) alignment 
Range on Protein: 446-547
Range on HMM: 92-186/244.0
EKPQNLHKNRFSDIIALNSCRVMLHKEHAdeESDYINAVFLHAHRGRNAFIATQHPLLETVEDFWRMVTDYDIGTIVMLNNLHdqvapESSEYWPDHGAT
 .|.| .||| .  . ..  || | |        |||| |.        .| ||||| .|  |||.|. .  .  .|.|  .      |  |||||    
fnpnnswknregaglpfdfnrvplskgsm..gntyinasfvgclgrtaeyiltqhpladtsmdfwkmmlerhvnvlvvlgsve.....eedeywpdsepl

KY
..
ew
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 159-277 2e-12 41.1 In-house 49-181 (349) alignment 
Range on Protein: 159-277
Range on HMM: 49-181/349.0
KNKNRYANIVAYDHSRVVLERVN--------------GDEDLDYINASFIHGYDGTP-RSFIASQGPLPPAFEGFWRMVWEQNSQSIVMLTNLVGLNKTK
  |||| .|. |.||||.|..                .    ||||| ...    .. . .|| | ||| . . |....  .. . .. |..   |.  |
faknrykdilPyehsrvklkkslksskvikastsesdsgklddyinanylkltrisvekkyiatqaPlPstvddfykvillngvklvlsLnddkelslek

CHKYWPDktETYGGVTVTLHQSE-VFAGYENCTFI
|..|| .   .| ..|| |  |    |. . ..  
cdiywqe..lsysnitvklqnsslyianvqGnslr
subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 497-611 3.7e-12 40.9 In-house 39-150 (255) alignment 
Range on Protein: 497-611
Range on HMM: 39-150/255.0
AtqhplleTVEDFWRMVTDYDIGTIVMLNNLHDQVAPESSEYWPDHGATKYGHIGISVLSKQKKGDVIC----VKPKVTRKKKTHEVRHLHHVSWTDKCI
        ||. |....   .  ..||| .....   . |.|.|     |     ..| . .   ||.     .  ....|||||.|.| ..  | .|  
l.......tvdkfyqtivqtktevvvmlcdfaeegvekcssyfplekdeklkladvnvtttkssadvvlrtleitstlgekkkthtvkhysykGWiekna

PKVSRSVLDLLDEVQTSQQ
|. .| .| .|  |. |. 
Pelareilnilkvvrdsks
subfamily_Sponge-PTP3_pd Subfamily Sponge-PTP3 113-209 1.9e-11 38.0 In-house 3-95 (95) alignment 
Range on Protein: 113-209
Range on HMM: 3-95/95.0
KPIPIALFPEYVAKMHGGI--RLETEYKKFNNGQQFPWGAARKPANknKNKNRYANIVAYDHSRVVLErvnGDEDLDYINASFIHGYDGTpRSFIASQG
||| ...|  .| .||      .. |.|  .     |. .    ||    |||. ||. || .||||       | ||||| |. ||      .||.||
kpihvsvfhshvlemhsnsdqefdnefksismtsgapytvgssean..ipknrflnifpydatrvvlt...tkrdsdyinacfvdgyark.ncyiaaqg
subfamily_hpo-7_pd Subfamily hpo-7 497-610 2.7e-11 37.9 In-house 42-155 (263) alignment 
Range on Protein: 497-610
Range on HMM: 42-155/263.0
AtqhpLLETVEDFWRMVTDYDIGTIVMLNNLHDQVAPESSEYWPDHGATKYGHIGISVLSKQKKGDVICVKPKVTR----KKKTHEVRHLHHVSWTDKCI
     |..|.. |....      ..||| . ...   . |.|.|     |     ..| . . . ||.    ...     |||||.|.|  .. | .|  
l....lvqtidkfyqtivqtktevvvmLcDfneegvekcssyfPlekdekqklanvnvcttkvqsdvllktlellstlgeKkkthtvkhysykgWieknd

PKVSRSVLDLLDEVQTSQ
|. .|..| .|. .. |.
pelareilnilkvarnsk
subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 446-524 2.8e-11 37.5 In-house 33-116 (347) alignment 
Range on Protein: 446-524
Range on HMM: 33-116/347.0
EKPQNLHKNRFSDIIALNSCRVMLHKEH-----ADEESDYINAVFLHAHRGRNAFIATQHPLLETVEDFWRMVTDYDIGTIVML
|  ..| |||  |    .. ||.|  |.     ||.   ||||  ..    .. .| ||.|| .|| |||.||.   .  .| .
ewekslsknrskdvklidatrvvlspeksknsraddvetyinashikfdnaskeyiltqyplpdtvrdfwkmvsvtkvtqvvti
subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 449-524 4.1e-11 37.0 In-house 46-114 (303) alignment 
Range on Protein: 449-524
Range on HMM: 46-114/303.0
QNLHKNRFSDIIALNSCRVMLHkehadeESDYINAVFLHAHRGRNAfIATQHPLLETVEDFWRMVTDYDIGTIVML
.|..|||| |.| |.  .| |       .| || | .|. .  ..| | || ||  |  |||.|. .  .  ...|
knmdknrfvdvicldhskvkls......dssyihasyleldsskka.iltqlplshtaadfwqmiieqkvkcvlll
subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 462-622 6e-11 37.0 In-house 30-198 (290) alignment 
Range on Protein: 462-622
Range on HMM: 30-198/290.0
LNSCRVMLHKEHADEESDYINAVFLHAHRGRnAFIATQHPLLET-------VEDFWRMVTDYDIGTIVMLNNLHDQVAPE----SSEYWPDHGA--TKYG
..  ||.|.       .||| | ..    |  ..|.|| |. ..       .|.|| |. .  .  .||| . ... |       ..| |..     |..
veatrvvLkgygkrfnddyiHAnrvtcpngl.rliltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCakYvpesvgeelkfk

HIGISVLSKQKKGDVICVKPKVT-RKKKTHEVRHLHHVSWTDKCIPKVSRSVLDLLDEVQTSQqqcgnVPVLVQC
 . ..  || |. ||.  .  |.  ... . | |   ..|..  ... ....|.|.. |..|.      ||.| |
gltvkCkskekeddvetRelvvkfddeeeftvtHsllkgWnklnvqedtktllsliqkvkask.....tpvivHc
subfamily_eak_pd Subfamily eak 324-402 6.6e-11 36.2 In-house 237-317 (332) alignment 
Range on Protein: 324-402
Range on HMM: 237-317/332.0
AGPvIVHCSVGVERTGAYIVIDAMLE--QAKKSRTVDIRNYLIAIRKHRPHMVQTKEQYSFIHSAVLEALTCGNTEIQS-EK
  | |. .. |  |.|...||| ...  ..||  .  . .... ....| | | .. |.|||. .||. |   | ...  .|
fap.iiqsarGsaraGvfvvidllirlidnkkknlysvedlilkvkskrihsvlvalqhsfiyeivldyllrrnnrlrdlkk
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 322-388 1.5e-10 35.4 In-house 260-341 (350) alignment 
Range on Protein: 322-388
Range on HMM: 260-341/350.0
RDAGPVIVHCSVGVERTGAYIVIDAMLE-------QAKKSRTVDIRNY--------LIAIRKHRPHMVQTKEQYSFIHSAVL
  . |..|||| || ||| .. .| .|.         |.|| .|  .         .  .|| |  |||...|. ||. |.|
arsspilvhCsaGvGrtGtlvtlDsllsdfeilenltkesrkldvaaktrDlisiivnelrkqrismvqnldqfifiYeall
subfamily_Sponge-PTP-2_pd Subfamily Sponge-PTP-2 157-254 3.4e-10 33.1 In-house 26-90 (169) alignment 
Range on Protein: 157-254
Range on HMM: 26-90/169.0
KNKNKNRYANIVAYDHSRVVLERVNGDEDLDYINAsfihgydgtprsfiasqgplppafegfwRMVWEQNSQSIVMLTNLVGLNktkchKYWPDKTET
 |. ||| |  .|  | || |.||  |   |||||                            ||.|| |.  ||.| .    |      .||.| . 
cnetknrpagplapshtrvklqrvmedlgsdyina............................rmiwetnasvivvlgdtddkn.....nfwpekedy
subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 157-302 4e-10 33.7 In-house 95-235 (244) alignment 
Range on Protein: 157-302
Range on HMM: 95-235/244.0
KNKNKNRYANIVAYDHSRVVLERvnGDEDLDYINASFIhGYDGTPRSFIASQGPLPPAFEGFWRMVWEQNSQSIVMLTNLvglnkTKCHKYWPDKT--ET
.|  ||| .  . .| .|| | .  |     ||||||. |  |    .| .| ||  .   ||.|. |.  . .|.|  .      .  .||||    | 
nnswknregaglpfdfnrvplsk..gsmgntyinasfv.gclgrtaeyiltqhpladtsmdfwkmmlerhvnvlvvlgsv.....eeedeywpdseplew

YG-GVTVTLHQSEVFAGYENCTFILSKEKRSGSRIVRQFHFTVWPDKGV
|   .|||| . . |       . .  .     . .  |  . ||  | 
yeeditvtltdrdefknikasnleiesdmneshqaltmfqisnwpsdgt
subfamily_Sponge-PTP2_pd Subfamily Sponge-PTP2 157-254 4.1e-10 32.7 In-house 25-89 (169) alignment 
Range on Protein: 157-254
Range on HMM: 25-89/169.0
KNKNKNRYANIVAYDHSRVVLERVNGDEDLDYINAsfihgydgtprsfiasqgplppafegfwRMVWEQNSQSIVMLTNLVGLNktkchKYWPDKTET
 |. ||| |  .|  | || |.||  |   |||||                            ||.|| |.  ||.| .    |      .||.| . 
cnetknrpagplapshtrvklqrvmedlgsdyina............................rmiwetnasvivvlGdtddkn.....nfwpekedy
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 438-542 2.3e-09 31.0 In-house 36-156 (349) alignment 
Range on Protein: 438-542
Range on HMM: 36-156/349.0
PVEEKSVGEKPQNLHKNRFSDIIALNSCRVMLHKE--------HADEE------SDYINAVFLHAHRG--RNAFIATQHPLLETVEDFWRMVTDYDIGTI
....  . |  .   |||..||.  .  ||.|.|         ..  |       ||||| .|.  |    . .|||| ||  ||.||.....   .  .
eiddvilseGvelfaknrykdilPyehsrvklkkslksskvikastsesdsgklddyinanylkltrisvekkyiatqaPlPstvddfykvillngvklv

VMLNNLHDQVAPESSEYWPDH
. ||. ...       || . 
lsLnddkelslekcdiywqel
subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 155-231 2.8e-09 31.0 In-house 34-114 (347) alignment 
Range on Protein: 155-231
Range on HMM: 34-114/347.0
ANKNKNKNRYANIVAYDHSRVVLERV-----NGDEDLDYINASFIHgYDGTPRSFIASQGPLPPAFEGFWRMVWEQNSQSIV
 .|. .|||  .    | .||||        . |.   ||||| |. .| . . .| .| ||| .   ||.||   .   .|
wekslsknrskdvklidatrvvlspeksknsraddvetyinashik.fdnaskeyiltqyplpdtvrdfwkmvsvtkvtqvv
subfamily_Sponge-PTP-4_pd Subfamily Sponge-PTP-4 477-558 4.3e-09 30.8 In-house 12-88 (130) alignment 
Range on Protein: 477-558
Range on HMM: 12-88/130.0
ESDYINAVFLHAHRGRNAFIATQHPLLETVEDFWRMVTDYDIGTIVMLNNLHdqvapESSEYWPDHGATKYGHIGISVLSKQ
. .|||| |.      . .. ||||| .|  |||.|. .  .  .|.|  .      |  |||||    ..    | | . .
gntyinasfvGllgrtaeylltqhpladtsmdfwkmmleryvnvlvvlgsve.....eedeywpdsePlewyeediivtltd
subfamily_Cele-PTP-12_pd Subfamily Cele-PTP-12 157-236 3.4e-08 27.4 In-house 33-110 (332) alignment 
Range on Protein: 157-236
Range on HMM: 33-110/332.0
KNKNKNRYANIVAYDHSRVVLERVNGDEdlDYINASFIHGYDGTpRSFIASQGPLPPAFEG-FWRMVWEQNSQSIVMLTNL
.| . ||   . ..||||| |   .| .  |. |||.. ||     ..| .| |.    |  ||||| |..   |... ..
nnmdmnriphlycfdhsrvelapqdgkd..dfynaswvdgyskk.sayifaqapfndhteyvfwrmvserkpsmilvfgdi
subfamily_Cele-PTP-12_pd Subfamily Cele-PTP-12 240-394 4.2e-08 27.0 In-house 146-306 (332) alignment 
Range on Protein: 240-394
Range on HMM: 146-306/332.0
NKTKCHKYWPDKTETYGGVTVTLHQSEVFAGYENCTFILSKEKRSGSRIVRQFHFTVWPDK-GVPQYATAVLAFRR--KVRALN--PRDAGPVIVHCSVG
.   |.|.||.|.      ..... |. ..     || |.  ..   .    .||  | |   .|.|   . |  .   .|. .      ||... |. |
kakicrkfwpekrskkdfpalsiqasddhsethmktfnltvtekkqdhqtvlmhfyewadasklpeymldmrasiklqyirsskktgvcigpimlvcatg

VERTGAYIVIDAMLEQAKKSRTVDIRNYLIAIRKHRPHMVQTKEQYSFIHSAVLE-ALTCG
||.   .  || .. .  . . | ... . ||. .|   ..|   ||     ... |.| |
vekcaisatidiivsriteehrvgfketmsaikmqrfgcfrtvgpystacemlmkfavttg
subfamily_Sponge-PTP3_pd Subfamily Sponge-PTP3 443-499 5.7e-08 26.8 In-house 41-94 (95) alignment 
Range on Protein: 443-499
Range on HMM: 41-94/95.0
SVGEKPQNLHKNRFSDIIALNSCRVMLHKEhadEESDYINAVFLHAHRGRNAFIATQ
.||    |. |||| .|.  .. ||.|       .||||||.|.  .  .|..||.|
tvgsseanipknrflnifpydatrvvlttk...rdsdyinacfvdgyarkncyiaaq
PTPc_DSPc_SM00012 579-623 7.1e-08 28.0 In-house 2-47 (105) alignment 
Range on Protein: 579-623
Range on HMM: 2-47/105.0
VRHLHHVSWTDKCIPKVSRSVLDLLDEVQTSQQQCG-NVPVLVQCR
|.|.|. .|.|...|. | |.|.||..|........ . ||.|.|.
vkhyhytgwpdhgvPeesdsilellravkknknksesskpvvVhCs
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 203-267 2.1e-07 24.6 In-house 237-300 (440) alignment 
Range on Protein: 203-267
Range on HMM: 237-300/440.0
SFIASQGPLPPAFEGFWRMVWEQNSQSIVMLTNlvgLNKTKCHKYWPDKTE--TYGGVTVTLHQSEV
.|||.| ||  .   |||.| . .  .|.|| .   ||   |  ||| .|   |.|  ||  . || 
afiatqmpldstvldfwrlvhdyristiimlnq...lndktcsiywpvntrsvtfgpftvghkgsen
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 577-623 6.2e-07 23.1 In-house 89-135 (440) alignment 
Range on Protein: 577-623
Range on HMM: 89-135/440.0
HEVRHLHHVSWTDKCIPKVSRSVLDLLDEVQTSQQQCGNVPVLVQCR
. ... |. .| || .||..  || ....|. ||...|| |.||.| 
rtlkqyhyqgwpdkgvpkfagpvlkmiqdvnesqekagngpllvhcs
subfamily_Sponge-PTP-4_pd Subfamily Sponge-PTP-4 172-301 6.5e-07 23.7 In-house 7-125 (130) alignment 
Range on Protein: 172-301
Range on HMM: 7-125/130.0
HSRVVlervngdeDLDYINASFIhGYDGTPRSFIASQGPLPPAFEGFWRMVWEQNSQSIVMLTNLvglnkTKCHKYWPDKT--ETY-GGVTVTLHQSEVF
 ||.         . .||||||. |  |  . .. .| ||  .   ||.|. |.    .|.|  .      .  .||||    | |   ..||| . . |
vsrlq........gntyinasfv.Gllgrtaeylltqhpladtsmdfwkmmleryvnvlvvlgsv.....eeedeywpdsePlewyeediivtltdrdef

AGYENCTFILSKEKRSGSRIVRQFHFTVWPDKG
   .   .  ...     . .  |. . ||  |
knikasnleiesdlneshqaltmfqisnwpsdg
subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 454-610 9.8e-07 22.8 In-house 47-209 (312) alignment 
Range on Protein: 454-610
Range on HMM: 47-209/312.0
NRFSDIIALNSCRVMLhkehADEESDYINAVFLHAHRGRNAFIATQHPLLETVEDFWRMVTDYDIGTIVMLNNLHDQVAPESSEYWPD---------HGA
||. .|   .  |  |    | .|  || | |..     . |..|| || .|.  ||...      .|..|  . .. . ....|  |         |  
nrypniqcwdrgrftl....agdenfyihanfvkictkperfvctqgplentcthfwqlalslgstsiillcgfvedgsekcakyisdivgfvdledhrv

-TKY-GHIGISVLSKQKKGD-VICVKPKVTrkKKTHEVRHLHHVSWTDKCIPKVSRSVLDLLDEVQTSQ
 |.|   | |   ||.|    |. |  | |   .   . |    || |. .|    . | ||  |.  .
yteycteieiggkskdkithrvlkvvvkat..gqesklnhyqwaswpdhgmpdscdtalrllsavkkdk
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 322-389 1.6e-06 21.7 In-house 263-342 (349) alignment 
Range on Protein: 322-389
Range on HMM: 263-342/349.0
RDAGPVIVHCSVGVERTGAYIVIDAMLE----QAKKSRTVDIRN-------YLI-AIRKHRPHMVQTKEQYSFIHSAVLE
 .  ...|||| |  ||| .. .| .|.      ..|  .....       . .  .|| |  |||   |. .|. |.|.
dqlstllvhcsaGcGrtGvlvtldlllsileplqnesnkiklqallkDlisiivnelrkqrismvqnlaqfiaiyealLk
subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 449-540 1.9e-06 21.5 In-house 50-139 (302) alignment 
Range on Protein: 449-540
Range on HMM: 50-139/302.0
QNLHKNRFSDIIALNSCRVMLHKEhadeESDYINAVFLHAHRGRNAFIATQHPLLETV---EDFWRMVTDYDIGTIVMLNNLHDQVApESSEYWP
.||.||.  |. .|.| .| |..|    . .|.||  ..    ..  | .| | ....   |.||||| .  | ..|.|    .      ||..|
knlkknqsedvpildsnlvkleae....pdsyvnaskvevPeltrsiilaQlpkvdsedsveeFWrmvfqekivsvvilvgeeelkk.tlselfp
0048179 (Phosphotyrosine protein) phosphatases II 552-624 1.9e-06 23.2 In-house 22-92 (144) alignment 
Range on Protein: 552-624
Range on HMM: 22-92/144.0
ISVLSKQKKGDVICVKPKVTRKKKTHEVRHLHHVSWTDKCIPKVSRSVLDLLDEVQTSQQqcGNVPVLVQCRY
.  | |.. . ||.. ..      ..|. ...|..| | ..|  .  .|..|. ... ..   . |||| |..
lellkklgittvinlteeyepefleregiqylhlpwpDhgvpdllellleflefieeale..eggpvlVHCsa
subfamily_PTPDC1_pd Subfamily PTPDC1 292-384 3.1e-06 21.7 In-house 85-169 (182) alignment 
Range on Protein: 292-384
Range on HMM: 85-169/182.0
FHFTVWPDKGVPQYATAvLAFRrKVRALNPrDAGPVIVHCSVGVERTGAyiVIDAMLEQAKKsrtVDIRNYLIAIRKHRPHMVQTKEQYSFIH
..   |.| ||.   .. |    || |    . | | |||  |  |||   .| ..|  ||.   ..  . .  .|..||. .||.||  ...
vynfgwkDygvasleri.Ldiv.kvvafal.qegkvavhChaGlGrtGv..liacylvyakr...ltaekaiklvrskrpksiqtreqvelvk
0038934 (Phosphotyrosine protein) phosphatases II 293-385 5.9e-06 21.6 In-house 83-171 (194) alignment 
Range on Protein: 293-385
Range on HMM: 83-171/194.0
HFTVWPDKG-VPQYATAVLAFRRKVRALNPRDAGPVIVHCSVGVERTGAYIVIdAMLEqakkSRTVDIRNYLIAIRKHRPHMVQTKEQYSFIHS
.   .||.| ||....    ..   . ||    | | |||  |. |||  ..  ....    ..  . .  .  .|  ||..... .... ...
lklpfpddgtvPsleillrfldlvdeflnedpggvvaVHCkaGlgRtGtlvaa.YLiy....rlgmsaeeAialfrekRpgaipnqdyleallk