Gene NvecPTP-sf2-4 in Nematostella vectensis

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily NvecPTP-sf2
Protein sequence
ID Type Fasta BLAST phosphatome Note
NvecP047_AA protein Get Run
NvecP047_AA_115-392 phosphatase_domain Get Run
NvecP047_AA_404-624 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_PTPRD_pd Subfamily PTPRD 112-626 1e-247 818.3 In-house 2-514 (564) alignment
Range on Protein: 112-626
Range on HMM: 2-514/564.0
SKPIPIALFPEYVAKMH--GGIRLETEYKKFNNGQQFPWGAARKPAnkNKNKNRYANIVAYDHSRVVLERVNGDEDLDYINASFIHGYDgTPRSFIASQG
|||||.| ..|.|||..  .....|.||||...||||.| ||.|||  ||.|||||||||||||||||..|.|||. ||||||||.||. .....||.||
skpipvaelkehvaklkansdlkfeeeykkieegqqftweaankpa..NkaKNRyanivaYdhsRVvLskvegdegsDYINAsfidgyr.krkayIAtqg

PLPPAFEGFWRMVWEQNSQSIVMLTNLVGLNKTKCHKYWPDK-TETYGGVTVTLHQSEVFAGYENCTFILSKEKRSGSRIVRQFHFTVWPDKGVPQYATA
||....| ||||||||||..|||||.|.  .|.|||||||.| |||||..||||...| .| || .||.|.|.|.| || ||||||| |||.|||..||.
PlaetiedFWRmvweqnsstiVmltkleEkgkvkchkYWPekgtetygeltVtleeeeeladyeirtfklkkkkssesreVrqFhFtsWPdhgvpesats

VLAFRRKVRALNPRDAGPVIVHCSVGVERTGAYIVIDAMLEQAKKSRTVDIRNYLIAIRKHRPHMVQTKEQYSFIHSAVLEALTCGNTEIQSEKYNQAMQ
.|...|||||||..||||..|||| ||.|||..||||||||..|...||||..|..|.||.|..||||.|||.|||.|.||||.|||||..||...|..|
lLdlirkvralnepdagPivVhCSaGVGRTGtfividamlerikeektvDiyqyvkalrkqRnamVqteeQYiFiheailealacgntevesenlkqhlq

KLASVNGKFPMTGYALEFQRLNsvTSREIPVEEKSVGEKPQNLHKNRFSDIIALNSCRVMLHKEHADEESDYINAVFLHAHRGRNAFIATQHPLLETVED
|||.|. .. |||..||||||.  |..||..||..|..||.|..|||||.|.||.||||.|....|.||||||||..|.|.|...||||||.|| .||||
kLaeveedtemtgleleFqrLa..takeieleefavatkpknkkknrfsnilalescrvvlsairakeesdyinasyleayrekrafiatqaplkntved

FWRMVTDYDIGTIVMLNNLHDQVAPESSEYWPDHGATKYGHIGISVLSKQKKGDVICVKPKVTRKKKTHEVRHLHHVSWTDKCIPKVSRSVLDLLDEVQT
|||||.......||||..|..... |||||..|..|||||.|.|.||.|..|.|....| ||..|.|...|..||.|...||.. .|..||||||..|..
fwrmvweeevkiivmltkleekleeesseyysdleatkyGeitikvlkkkeksdilfrkkkvevkekseavyllhtvqavdkklltvidsvldllkavrk

SQQQCGNVPVLVQCRYNK
..... .|.|  ..... 
vleravvvrvsegvtvtg

subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 109-399 8.3e-130 427.4 In-house 3-298 (298) alignment
Range on Protein: 109-399
Range on HMM: 3-298/298.0
DDLSKPIPIALFPEYVAKMH--GGIRLETEYKKFNNGQQ----FPWGAARKPAnkNKNKNRYANIVAYDHSRVVLERVNGDEDLDYINASFIHGYDGTPr
....... .|......|...  . .....|....|....    . . .||||.  ||.|||||.|.|.|.||||||....||. |||||||.|.|.|.. 
teieaedlkaalqklaavkkkkkltgyalefqrlnsvsseieeeekevarkpe..nkkkNRyadiialdssRvvLekedadeesdYiNAsflhaykgrn.

SFIASQGPLPPAFEGFWRMVWEQNSQSIVMLTNLVGLNKTKCHKYWPD-KTETYGGVTVTLHQSEVFAGYENCTFILSKEKRSGSRIVRQFHFTVWPDKG
.|||.|.||....|.|||||.|.....|||||||. |.|||.|||||| ..|||| .||.|...|.|| ........||.|....| |||.|||.|||||
afiatqaPltetvedFWrmvteedigtiVmltnleeldktkyhkywPdegketygeitvsllskeefadlivrklkvskkkeekerevrqlhftsWpdkg

VPQYATAVLAFRRKVRAlNPRDAG--PVIVHCSVGVERTGAYIVIDAMLEQAKKSRTVDIRNYLIAIRKHRPHMVQTKEQYSFIHSAVLEALTCGNTEIQ
||..||.||...||||| ....||  ||||.|| ||.|.|..|.||..||..||...||........||.||..|||.|||.||..||||||...|.||.
vpenatsvldllrkvra.sqqqagnkpvivqCsaGvgRsGtfiaidsvlervkkeqvvDvfqvvkvlRkkrpgavqteeqYvfiyeavlealdsfndeie





subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 151-400 5.9e-118 387.6 In-house 4-245 (250) alignment
Range on Protein: 151-400
Range on HMM: 4-245/250.0
ARKPAnkNKNKNRYANIVAYDHSRVVLERVNGDEDLDYINASFIHGYDGTpRSFIASQGPLPPAFEGFWRMVWEQNSQSIVMLTNLVGLNKTkCHKYWP-
|.||.  ||.|||||.|.|.|.||||||...||.. |||||||.||||.. ..|||.||||....|.|||||.|..|..|||||||.  .|| .|.||| 
akkpq..nkeknryadiialdssrvvLekekgdkesdyinasflhgyder.kafiatqgPlqatiedfWrmvleeksgtivmLtnLkesekt.yhqywPv

DKTETYGGVTVTLHQSEVFAGYENCTFILSKEKRSGSRIVRQFHFTVWPDKGVPQYATAVLAFRRKVRALNPR-DAGPVIVHCSVGVERTGAYIVIDAML
.|.|.||.|||.|...|.|| |.  ...|||.|....|||||.||.||||||||..|||||....||.| ... ...||||.|| || |.||.|.|||.|
ekaekyGdvtvsllskeefadytkrklklskakkaderivrqlhfvvWPdkgvPevatavLellkkvqasqqqagnaPvivqCsaGvgrsGafiaidavl

EQAKKSRTVDIRNYLIAIRKHRPHMVQTKEQYSFIHSAVLEALTCgnteiqS
|..||...||........||.|||.|...|||.|.....|.||..      .
erlkkekvvdvfkvikvlrkdrphavesleqyvfvyeiilkalds......v

subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 117-429 2.2e-103 340.6 In-house 4-318 (318) alignment
Range on Protein: 117-429
Range on HMM: 4-318/318.0
IALFPEYVAKM--HGGIRLETEYKKF-NNGQQFPWGAARKPANKnkNKNRYANIVAYDHSRVVLERVNGDEDLDYINASFIHGYDgTPRSFIASQGPLPP
.  . . |...  .| . |..||...  . ... .  . .|.||  .|||||||.||||.|| |. ..|.|. |||||..| ||    ...||.|.||| 
vedleshvrrlresGelllseeyerlsrseetvtslkslepvnk..aknryanilaydhtrvkLqmlegeegsDyinanyidGyr.rkkayiaaqaPlpe

AFEGFWRMVWEQNSQSIVMLTNLVGLNKTKCHKYWPDK-TETYGGVTVTLHQSEVFAGYENCTFILSKEKRSGSRIVRQFHFTVWPDKGVPQYATAVLAF
..| ||||||||||. |||||...   |.|.|.|||.| ...|| ..|.|...  .. |   .| ..... . ||.|||.|.| |||.|||. .. .|..
tieDfWrmvWeqnsavivmltqeeergkakvhryWPskgsrsygklvvelkeevelsdyvlrefkvtrteeeesrqvrqyhytsWpdegvpesgaslldl

RRKVRALN-PRDAGPVIVHCSVGVERTGAYIVIDAMLEQAKKSRTVDIRNYLIAIRKHRPHMVQTKEQYSFIHSAVLEALTCGNTEIQSEKYNQAMQKLA
 |.|.. . . .|||..|||| || ||| .|..|..||..|.  .||. ..   .|..|. ||||..|| ||. ..||||..|.||..... .. ...| 
vrqvskaqqksgagpivvhCsaGvGrtGvfiavdillerikaealvDvfqtvkqlreqrnlmvqtedqyefiydvllealasgdtevdasdlrsrirelr

SVNGKFPMTGYALEFQRL
 .. .  .|   .|||||
eqdpesgttemdaefqrl

subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 394-622 1e-102 338.4 In-house 1-230 (298) alignment
Range on Protein: 394-622
Range on HMM: 1-230/298.0
GNTEIQSEKYNQAMQKLASVNGKFPMTGYALEFQRLNSVTSrEIPVEEKSVGEKPQNLHKNRFSDIIALNSCRVMLHKEHADEESDYINAVFLHAHRGRN
|||||..|....|.||||.|. |. .|||||||||||||.| ||. |||.|..||.| .|||..|||||.|.||.|.||.||||||||||.||||..|||
gnteieaedlkaalqklaavkkkkkltgyalefqrlnsvss.eieeeekevarkpenkkkNRyadiialdssRvvLekedadeesdYiNAsflhaykgrn

AFIATQHPLLETVEDFWRMVTDYDIGTIVMLNNLHDQVAPESSEYWPDHGATKYGHIGISVLSKQKKGDVICVKPKVTRKK--KTHEVRHLHHVSWTDKC
||||||.|| |||||||||||..||||||||.||...   . ..||||.|...||.| .|.|||....|.|..| ||..||  |..|||.||..||.||.
afiatqaPltetvedFWrmvteedigtiVmltnleeldktkyhkywPdegketygeitvsllskeefadlivrklkvskkkeekerevrqlhftsWpdkg

IPKVSRSVLDLLDEVQTSQQQCGNVPVLVQC
.|....||||||..|..||||.||.||.|||
vpenatsvldllrkvrasqqqagnkpvivqC

subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 115-427 1.5e-96 318.2 In-house 5-319 (319) alignment
Range on Protein: 115-427
Range on HMM: 5-319/319.0
IPIALFPEYVAKMH--GGIRLETEYKKFNNGQQFPWGAARKPanKNKNKNRYANIVAYDHSRVVLERVNGDEDLDYINASFIHGYDGTpRSFIASQGPLP
|... . |.. ...  |   || |.|........ .  | |.  .||.|||| ||.|||..||||  ..| |. |||||||| ||.   . ||| |.|| 
ievqeLkerlkalastgetllekefkllkeavndtfdsaske..enkkknryqnilaydrtrvvlseldgvegsdyinasfidgyqer.ekfiatqaPle

PAFEGFWRMVWEQNSQSIVMLTNLVGLNKTKCHKYWPDKT-ETYGGVTVTLHQSEVFAGYENCTFILSKEKRSG-SRIVRQFHFTVWPDKGVPQYATAVL
 ..| |||||||..|  .||||.||   | |..||||... |.|| ..||| . |  ..|.   . | | .    .| | .|..| |||..||..||..|
ntiedfWrmvWeeessivvmltklveklkvklkkywpeenfeeyGrlivtleeeeeledyiirklklnkkssevetRevkhfqyteWpdhdvPekatsll

AFRRKVRALNPR-DAGPVIVHCSVGVERTGAYIVIDAMLEQAKKSRTVDIRNYLIAIRKHRPHMVQTKEQYSFIHSAVLEALTCGNTEIQSEKYNQAMQK
.. ...|    . ..||..|||| || |||..||.|||||. |.  ..|. ..   .|  |. |||..|||.||. |.|||...|.|||. .. .. ...
dllkrirksrektqsgPivvhCsaGvGRtGtfivldamlervkeegvlDvfstvsrlRtqRnimvqrpeqYkfiyealleaveagdteievqdlrdrlkq

LASVNGKFPMTGYALEFQ
||. . .  .|| . |||
laekvadtgetglerefq

subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 157-390 4.8e-96 315.5 In-house 6-239 (239) alignment
Range on Protein: 157-390
Range on HMM: 6-239/239.0
KNKNKNRYANIVAYDHSRVVLERVNGDEDLDYINASFIHGYDGTPRSFIASQGPLPPAFEGFWRMVWEQNSQSIVMLTNLVGLNKTKCHKYWPDKTETYG
 || ||||||||.|||||||||... |   ||||||... |||.|...||.|| . ..   ||||.|..    ||||| |.   | |||.|||| |  | 
vnkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdstskyc

GVTVTLHQSEVFAGYENCTFILSKEKRSGSRIVRQFHFTVWPDKGVPQYATAVLAFRRKVRALNPRDAGPVIVHCSVGVERTGAYIVIDAMLEQAKKSRT
 . |||...|||| |   ||..|.  ..  | | |.|||||||||||||||||| .|||.   .   | | ..||| || ||||..|||||| |||| .|
nlrvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcsagvgrtgaflvidamlrqakkqkt

VDIRNYLIAIRKHRPHMVQTKEQYSFIHSAVLEA
||| ||. |||. ||||||| ||| ||| |||||
vdifnyvkairedrphmvqtseqyvfihlavlea

subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 156-389 1.5e-95 313.9 In-house 6-239 (239) alignment
Range on Protein: 156-389
Range on HMM: 6-239/239.0
NKNKNKNRYANIVAYDHSRVVLERVNGDEDLDYINASFIHGYDGTPRSFIASQGPLPPAFEGFWRMVWEQNSQSIVMLTNLVGLNKTKCHKYWPDKTETY
  || ||||||||.|||||||||... |   ||||||... |||.|...||.|| . ..   ||||.|..    ||||| |.   | |||.|||| |  |
rvnkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdstsky

GGVTVTLHQSEVFAGYENCTFILSKEKRSGSRIVRQFHFTVWPDKGVPQYATAVLAFRRKVRALNPRDAGPVIVHCSVGVERTGAYIVIDAMLEQAKKSR
  . |||...|||| |   ||..|.  ..  | | |.|||||||||||||||||| .|||.   .   | | ..||| || ||||..|||||| |||| .
cnlrvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcsagvgrtgaflvidamlrqakkqk

TVDIRNYLIAIRKHRPHMVQTKEQYSFIHSAVLE
|||| ||. |||. ||||||| ||| ||| ||||
tvdifnyvkairedrphmvqtseqyvfihlavle

subfamily_PTPRG_pd Subfamily PTPRG 115-405 2.1e-95 315.1 In-house 1-301 (563) alignment
Range on Protein: 115-405
Range on HMM: 1-301/563.0
IPIALFPEYVAKMHG--GIRLETEYK---KFNNGQQFPWGAARKPanKNKNKNRYANIVAYDHSRVVLERVNGD-EDLDYINASFIHGYDgTPRSFIASQ
.|.  | ..||..|    |... |..   .  . ....  ...||  .||.|||| ||||||.||| |. . |  ..||||||..|.||    . |||.|
vpvkefakhvaslhadgdigfseefealqsetiskdldaehsqkp..enkrKnRylnivaydrsRvklsplpgkkkklDYinAnyidGyq.kskafiatq

GPLPPAFEGFWRMVWEQNSQSIVMLTNLVGLNKTKCHKYWP-DKTETYGGVTVTLHQSEVFAGYENCTFILSK------EKRSGSRIVRQFHFTVWPDKG
|||.  |. ||||.||||.. |||.||||  .. ||. ||| |..|||| ..||| ..||.| |   |... .      ...   . |||.|.| |||.|
gplkdtfddFWrmiWeqnvaiivmitnlvergrrkcdvYWPkdesetygalqvtlieeevlalytvrtlviknlklkkkkqcdteklvrqyhytkWPdhg

VPQYATAVLAFRRKVRALNPRDAGPVIVHCSVGVERTGAYIVIDAMLEQAKKSRTVDIRNYLIAIRKHRPHMVQTKEQYSFIHSAVLEALTCGNTEIQSE
||.... || | .|  | |...|||..|||| || ||| |||.|..|.| ..  .|.. . |  || .|...|||.||| |.| |.|||.. ..||...|
vPehslpvLifvkkssaankaeaGPivvHcsaGvgrtGtyivldtllkqiqqenavnvfgflkhiraqRnflvqteEqYiflhdalleaiasketellae

KYNQ
. ..
qvee

0050432 (Phosphotyrosine protein) phosphatases II 103-395 2.1e-91 301.7 In-house 14-303 (308) alignment
Range on Protein: 103-395
Range on HMM: 14-303/308.0
ICDNAVDDLSKPIPIALFPEYVAKMHGGIRLETEYKKFNNGQQfPWGAARKPANKNKNKNRYANIVAYDHSRVVLervngDEDLDYINASFIHGYD-GTP
 .|. .   |.....  . ... |...  .||.|...... .  ..        .||.|||| .|..||||||.|     ||. ||||||...||. . |
frdtsilvsslklsvldllkllekaldlglleeefeellsvkp.lleysvallpenkdkNrykdilpydhsRVkl.....degsdYInAsyvdgyssklp

RSFIASQGPLPPAFEGFWRMVWEQNSQSIVMLTNLVGLNKTKCHKYWPD----KTETYGGVTVTLHQSEVFAGYENCTFILSKEKRSGSRIVRQFHFTVW
| ||| |||||  .| |||||||||.. |||||.||  .. ||..|||.    ....||..||||   ||...|   |..|.. . . ||.|..||.| |
rkfIatqgPlpntvedFwrmvweqnvrvIvmLtklvengrekcaqYwplelgggsleygkftvtllseevlddytvrtleltnlgdgesrtvthfhytnW

PDKGVPQYATAVLAFRRKVRALNprDAGPVIVHCSVGVERTGAYIVIDAMLEQAKKSRTVDIRNYLIAIRKHRPHMVQTKEQYSFIHSAVLEALTCGN
|| |||......|.| ..||  .  . ||..|||| || |||..|..| .||| .| ..||. ...  .|..||.||||.||| |.. |.|| | .  
pdhgvPpspeilldflelvrksl..pggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtpeqylflyralleylklkl

0040438 (Phosphotyrosine protein) phosphatases II 129-409 2.8e-91 301.4 In-house 17-294 (317) alignment
Range on Protein: 129-409
Range on HMM: 17-294/317.0
GgIRLETEYKKFNNGQQFPWGAARKPANKNknKNRYANIVAYDHSRVVLERVNGDEDLDYINASFIHGYDGTPRsFIASQGPLPPAFEGFWRMVWEQNSQ
   .|. |.... . .  ..  |..|.||.  |||| .|. ||||||.|  ..||.|.||||||...|.. ... ||| |||||  .| ||||||||...
f.talleefedllslkldtysvaelpenkd..knrypdilpydhsRVkLsplggdldsdYInAsyvdgpnlkrk.fIatqgPlpntvedFwrmvweqgvt

SIVMLTNLVGLNKTKCHKYWP-DKTETYGGVTVTLHQSEVFAGYENCTFILSKEKRSGSRIVRQFHFTVWPDKGVPQYATAVLAFRRKVRALNPRDAGPV
.|||||.|. |.. ||..||| ..| |||..|||| . |. ||..  |. ... . | ||.|..||.| ||| |||.. . .|.| ..||. .... |||
vivmLteleelgrekcaqYwplgetltygdftvtllseeelagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfleavrealedpggpv

IVHCSVGVERTGAYIVIDAMLEQAKKSRTVDIRNYLIAIRKHRPHMVQTKEQYSFIHSAVLEALTCGNTEIQSEKYNQAMQK
.|||| || |||..|... |||| .| ..||. . .  .|..||..||| ||| |.. |.|| |....| .   ..  ...|
lVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalleylkrkltlepaselklkllk

subfamily_PTPRB_pd Subfamily PTPRB 112-393 6.7e-90 296.1 In-house 4-287 (293) alignment
Range on Protein: 112-393
Range on HMM: 4-287/293.0
SKPIPIALFPEYVAKMH--GGIRLETEYKKFNN-GQQFPWGAARKPAnkNKNKNRYANIVAYDHSRVVLERVNGDEDLDYINASFIHGYDgTPRSFIASQ
|||| .  | |.|.||.    .|.  ||..... |..    ||....  |..|||| ||..|||||| |. ...... |||||..|.||  .|| |||.|
skpiklekfeehvkkmkadsdlrfseeyeelkavgkdqavkaaelav..nraknrytnilpydhsrvkLaalkdesgsDYinanyipgyn.sprefiatq

GPLPPAFEGFWRMVWEQNSQSIVMLTNLVGLNKTKCHKYWPDK--TETYGGVTVTLHQSEVFAGYENCTFILSKEKRsgSRIVRQFHFTVWPDKGVPQYA
|||| ... |||||||..|. |||||.||   |.||..|||..  . .|| ..||| ..|.   .   .. ..|||.  .| |||.||| ||| |||. .
GPlpetvddfWrmvwekkssiivmltqlvekgkvkCeeYWPadeepvlyGdikvtlvaeeeledwvirelkiekeke..erkvrqyhftsWpdhgvPekt

TAVLAFRRKVRALN--PRDAGPVIVHCSVGVERTGAYIVIDAMLEQAKKSRTVDIRNYLIAIRKHRPHMVQTKEQYSFIHSAVLEALTC
...|.| |.||       ...|..|||| || |||..| .| .|.. ... .|||   ....|..| ..|||..|| |||..||. |. 
ktlldfvrtvreaiektaskrPivvhCsaGvGRtGtfialdrllqaieeedyvdifgivaelReeRnllvqtekqYifihqcvldllrk

subfamily_PTPRK_pd Subfamily PTPRK 130-408 9e-90 295.7 In-house 21-294 (314) alignment
Range on Protein: 130-408
Range on HMM: 21-294/314.0
GIRLETEYKKFNNGqqfpWGAARKpaNKNKNKNRYANIVAYDHSRVVLERVNGDEDLDYINASFIHGYDgTPRSFIASQGPLPPAFEGFWRMVWEQNSQS
|  .  ||. . .|    | ||.|  ..|..|||. .|.|||.|||.|  ..|| . |||||..| .|   |. ||. ||||.   . |||.|...|. |
gygfkeeyeslfeg....wdaakk..denreknrsgdilaydrsrvflitidgdpssdyinaalidsyk.rpaafivtqgPlqetvkdfWrlvydencas

IVMLTNLVGLNKTKCHKYWPDKTETYGGVTVTLHQSEVFAGYENCTFILSK--EKRSGSRIVRQFHFTVWPDKGVPQYATAVLAFRRKVRALNPRDAGPV
|||||.||   . || ||||..||.|| . |.| ..|. | . . .| ..|   . .. |.||||.|. ||| .||..||..|.. |.| . .. .||..
ivmltelvevgrvkClkyWPedtevygdikvelvetellaelvvrifrveklargqeeirevrqfqflgWpdhdvPvsatgllklvrrvkksqeeeaGri

IVHCSVGVERTGAYIVIDAMLEQAKKSRTVDIRNYLIAIRKHRPHMVQTKEQYSFIHSAVLEALTCGNTEIQSEKYNQAMQ
.|||| |  |||..|.|| .|. ... ..||. |   ..|.... ||.|.||| ||. ..|||  ||.| |   ... .  
vvhCsaGaGrtGtfiaidivldmieregvvdvfnavktlrsrkvnmveteeqykfiydvileaclcgetaipvsefkalyl

0051299 (Phosphotyrosine protein) phosphatases II 127-391 4.6e-89 293.9 In-house 19-286 (288) alignment
Range on Protein: 127-391
Range on HMM: 19-286/288.0
MHGGIRLETEYKKFNNGQQFpWGAARKPANKNKNKNRYANIVAYDHSRVVLERVNGDEDLDYINASFIHGYDGTPRsFIASQGPLPPAFEGFWRMVWEQN
..|  .|. |.... . .   .        .|..|||| .|..||||||.|  ..|.|. ||||||.|.||. . . ||| |||||  .| |||||||||
angltglleefeellsllpd.ltlsaallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyidgynlkrk.fIatqgPlpntvedFWrmvweqn

SQSIVMLTNLVGLNKTKCHKYWP-DKTETYGGVTVTLHQSEVFAGYENCTFILSKE----KRSGSRIVRQFHFTVWPDKGVPQYATAVLAFRRKVRALNP
.. |||||.|| |...||..||| ....||| .||||   ||...|   |.....     . . ||.|..||.| ||| |||......|.| |.||  ..
vrvIvmltklvelgrekcaqYwplggsltygditvtllseevlddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpdspellldflrlvrkala

RDAGPVIVHCSVGVERTGAYIVIDAMLEQAKKSRTVDIRNYLIAIRKHRPHMVQTKEQYSFIHSAVLEAL
 . |||.|||| || |||..|..| .||| .| ..||. ...  .|..||.|||| ||| |.. |.||.|
sgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtpeqyrfvyealleyl

subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 113-411 2.8e-88 290.9 In-house 4-299 (315) alignment
Range on Protein: 113-411
Range on HMM: 4-299/315.0
KPIPIALFPEYVAKMHGGIR--LETEYKKFNNGQQFPWGAARKPanKNKNKNRYANIVAYDHSRVVLERVNGDEDLDYINASFIHGYDgTPRSFIASQGP
.|||.  .  |||. .   .  .. .|.    || .|   |.|   .||.|||| ||.|||.||| |  .. |.. ||.||.|| ||.  .| .||.|||
qpipldqlityvaqkkastkngfkqdyesipggqlhpldvakki..enkqknryiniiaydksrvqlpllendphsdyvnanfidGyn.kkrryiaaqgp

LPPAFEGFWRMVWEQNSQSIVMLTNLVGLNKTKCHKYWPDKTETYGGVTVTLHQSEVFAGYENCTFilSKEKRSGSRIVRQFHFTVWPDKGVPQYATAVL
.. . . |||.|.|..   ||||||||  .| |. ||||||  .|| .|||. . ||.  |   |.  |   ..  | | |.|.| ||| |||.|.....
nvasvkdfwrlvfeedigkivmltnlvegekrkaekywpdkkviyGkitvtrkseevnteytvrtl..svvfgdnirevvqlhytswpdmgvpkytiplm

AFRRKVRALNPRDAGPVIVHCSVGVERTGAYIVIDAMLEQAKKSRTVDIRNYLIAIRKHRPHMVQTKEQYSFIHSAVLEALTCGNTEIQSEKYNQAMQKL
 . |.|.  .  ..|...|||| || |||..| .||.|.||.  . .|. |..  .|. | .|||. ||| ||..|.||.. ||.| |  . | |  . |
nlirtvkqhhtnsvgaivvhcsaGvGrtGtfitldavldqaeaenaidvynfitgvrqnrikmvqvaeqyqfiydalletfvcgdtsiaqdlylqrydsl

A
 
l

subfamily_PTPRA_pd Subfamily PTPRA 155-422 5.3e-88 290.1 In-house 55-326 (330) alignment
Range on Protein: 155-422
Range on HMM: 55-326/330.0
ANKNKNKNRYANIVAYDHSRVVLERVNGDEDLDYINASFIHGYDGTpRSFIASQGPLPPAFEGFWRMVWEQNSQSIVMLTNLVGLNKTKCHKYWPDK-TE
 ..||.|||. ||. ||.|||.|  ..| |. ||||||||.||     .|||.|||.  . | ||||.|||.|..|||||.|   ...||..||||. . 
keenkeknrvvnilPydfsrvilsvkeGveesdyinasfidGykek.dkfiaaqGPkeetvedfwrmiweqksativmltelkerkeekcaqywPdeGlv

TYGGVTVTLHQSEVFAGYENCTFILS----KEKRSGSRIVRQFHFTVWPDKGVPQYATAVLAFRRKVRALNPRDAGPVIVHCSVGVERTGAYIVIDAMLE
||| ..|......|   |    |..     . ..  ||.||||||| ||| |||  .  .| . .||..||.. |||..|||| || |||..||.||.||
tyGnirvevedetvlvdytvrkflvqqlpdatrekksrlvrqfhftswPdvGvPfepiGmlkllkkvkklnqqsagpivvhcsaGvGrtGtfivldavle

QAKKSRTVDIRNYLIAIRKHRPHMVQTKEQYSFIHSAVLEALTCGNTEIQSEKYNQAMQKLASVNGKFPMTGY
. |  | ||. . .  .|. ||.||||.||| ||. ..||    |.||..    .. .||| .   ..  .| 
rvkaerkvdvfefvkrlrlqrpqmvqtdeqyefiykvlleyylygdteldvsslekhlqklynkitgtdkigl

0046845 (Phosphotyrosine protein) phosphatases II 133-396 3.2e-86 284.5 In-house 2-279 (284) alignment
Range on Protein: 133-396
Range on HMM: 2-279/284.0
LETEYKKFNNGQQFPW-GAARKPANKNKNKNRYANIVAYDHSRVVLERVNGD-EDLDYINASFIHGYD----GTPRSFIASQGPLPPAFEGFWRMVWEQN
|| |... .. . ...       . .|..|||| .|..||||||.| ...|| || ||||||...|||     ... ||| |||||  .| |||||||||
leeefeellsltvklllslsvallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweqn

SQSIVMLTNLVGLNKTKCHKYWPDK--TETYGGVTVTLHQSEVFAGYENCTFILSKEK-RSGSRIVRQFHFTVWPDKGVPQYATAVLAFRRKVRALNP--
.. |||||.||  ...||..|||..  . |||..||||   ||. .|   |. |....  . ||.|..||.| ||| |||.... .|.| |.|| |..  
vrvIVmltelvengrekcaqYwplegevltygdftvtllseevkddytvrtleltnlgytgesrtvthfhytswpdhgvppspedlleflrlvrellenl

RDAGPVIVHCSVGVERTGAYIVIDAMLEQAKKSR---TVDIRNYLIAIRKHRPHMVQTKEQYSFIHSAVLEALTCGNT
 . ||..|||| || |||..|..| .||| .| .   .||. ...  .|..||.|||| ||| |.. |.||.| ...|
pgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyealleylklklt

subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 157-389 6.3e-86 282.5 In-house 2-237 (237) alignment
Range on Protein: 157-389
Range on HMM: 2-237/237.0
KNKNKNRYANIVAYDHSRVVLERVNGDedLDYINASFIHGYDGTPRSFIASQGPLPPAFEGFWRMVWEQNSQSIVMLTNLVGLNKTKCHKYWPD--KTET
.|| ||||.||||||||||||.   ..   |||||....|.||||...||.|||| .. . ||.|||...   ||||| |.  |. |||||||.  . ..
enkiknrygnivaydhsrvvlkgagsg..sdyinatylkgfdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywpstdqpaa

YGGVTVTLHQSEVFAGYENCTFILSKE-KRSGSRIVRQFHFTVWPDKGVPQYATAVLAFRRKVRALNPR--DAGPVIVHCSVGVERTGAYIVIDAMLEQA
|| .||.|.. | |. |   ...|||. .  . |.. |..||.|||.||||...|.| ||...   .|   ..|| |.||| || ||| ..|||||| ||
ygvltvslkkkeefsdytvrslllskrltlkevrlihqyqftswpdrgvpqqtaallrfrkniinrsphvsesgpwiihcsagvgrtgiflvidamlrqa

KKSRTVDIRNYLIAIRKHRPHMVQTKEQYSFIHSAVLE
|. . ||| ||. .| . ||...|||.|| ||| ..||
kekkvvdiynyvysieedrpyiiqtkdqyvfihqtile

0036941 (Phosphotyrosine protein) phosphatases II 147-402 9.9e-86 283.0 In-house 28-288 (297) alignment
Range on Protein: 147-402
Range on HMM: 28-288/297.0
PWGAARKPANKNKNKNRYANIVAYDHSRVVLervnGDEDLDYINASFIHGYDGTPRsFIASQGPLPPAFEGFWRMVWEQNSQSIVMLTNLVGLNKTKCHK
..        .|..|||| .|..|||.||.|    .||. ||||||.. ||| . . ||| |||||  .| |||||||||...|||||.|| |.. ||..
lgslsvallpenleknRykdilpydhtRVkl....ddegsdYinAsyvdgydlkrk.fIatqgPlpntvedFWrmvweqnvtvIvmltelvelgrekcaq

YWP---DKTETYGGVTVTLHQSEV--FAGYENCTFILSKEKRSGSRIVRQFHFTVWPDKGVPQYATAVLAFRRKVRALNPR--DAGPVIVHCSVGVERTG
|||   ... |||..||||   ||  ...|   |. ... . . ||.|..||.| ||| |||.... .|.| ..||  ..   . |||.|||| || |.|
ywpleegesltygdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfielvrkvlkllpsggpvlVHCsaGvgRsg

AYIVIDAMLEQAK---KSRTVDIRNYLIAIRKHRPHMVQTKEQYSFIHSAVLEALTCGNTEIQSEK
..|..| ||.| .   | ..||| ...  .|..||..||| ||| |.. |.|| | ...| ..  |
tfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallellkkkltkepllk

0039614 (Phosphotyrosine protein) phosphatases II 107-395 1.6e-84 279.2 In-house 8-293 (297) alignment
Range on Protein: 107-395
Range on HMM: 8-293/297.0
AVDDLSKPIPIALFPEYVAKMHGGIRLETEYKKFNNGQQfPWGAARKPanKNKNKNRYANIVAYDHSRVVLERVNG-DEDLDYINASFIHGYDGTPRSFI
...  ..|. .  .   . |. .  .|..|...  . .  ..  |..|  .||.|||| .|..||||||.|  ..| |.|.||||||.. ||| ..| ||
llesipiplsvldlllllekansktllllefeellslkp.dysiallp..enkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfI

ASQGPLPPAFEGFWRMVWEQNSQSIVMLTNLVGLNKtKCHKYWPDKTETYGGVTVTLHQSEVFAGYENCTFILSKekRSGSRIVRQFHFTVWPDKGVPQY
|.|||||  .| ||||||||....|||||.|| |.. ||..|||....|||..|||| . |. .||   |. ...   . ||.|..|..| ||| |||..
atqgPlpetvedFwrmvweqgvtvivmLtklvelgr.kcaqywpeeggtygdftvtllkvehldgytvrtlevtn..ngesrtvthfqytgwpdhgvpps

ATAVLAFRRKVRALNPR--DAGPVIVHCSVGVERTGAYIVIDAMLEQAKKSRTVDIRNYLIAIRKHRPHMVQTKEQYSFIHSAVLEALTCGN
.. .| | ..||  . .  . |||.|||| || |||..|... |||| .| ..||. . .  .|..||..||| .|| |.. |.|| | ...
lellleflelvrealaelpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydallellkrkl

0043336 (Phosphotyrosine protein) phosphatases II 128-389 3.3e-84 277.9 In-house 17-275 (278) alignment
Range on Protein: 128-389
Range on HMM: 17-275/278.0
HGGIRLETEYKKFNNGQQFPWGAARKPANKNknKNRYANIVAYDHSRVVLERVNGDEDLDYINASFIHGYDGTPRsFIASQGPLPPAFEGFWRMVWEQNS
 .  .|. |...... . ...  |..|.||.  |||| .|..||||||.|. ..||.|.||||||.. ||. ... |||.|||||  .| |||||||...
nlktllllefeellsfkldtysiallpenkd..knrykdilpydhsrvklsllggdldsdYinAsyvdgynvprk.fiatqgPlpetvedFwrmvwelgv

QSIVMLTNLVGLNKTKCHKYWPDKTETYGGVTVTLHQSEVFAGYENCTFILSKEKRSGSRIVRQFHFTVWPDKGVPQYATAVLAFRRKVRALNPRDAGPV
..|||||.|| |...||..|||....|||..||||   |....|   |. ... . . ||.|...|.. ||| |||   . .| | ..||  .. . |||
ttivmLtelvelgrvkcaqYwpggsltygdftvtllkeehlddytvrtlevtnlgdgesrtvthyhylgwpdhgvpeslsllldflkavrealedsngpv

IVHCSVGVERTGAYIVIDAMLEQAKKSRTVDIRNYLIAIRKHRPHMVQTKEQYSFIHSAVLE
.|||| || |||..|... .|||..| ..||. . .  .|..||..||| .|| |.. |.||
lVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflyealle

subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 133-392 6.7e-84 276.3 In-house 17-277 (281) alignment
Range on Protein: 133-392
Range on HMM: 17-277/281.0
LETEYKKFNN-GQQFPWGAARKPAnkNKNKNRYANIVAYDHSRVVLERVNGDEDLDYINASFIHGYDGtPRSFIASQGPLPPAFEGFWRMVWEQNSQSIV
. .||.|... |.. .  |.....  |..|||| ||||||..||.... . ... |||||.|. ||.| .. .||.|||.| ... ||.|||||. . ||
fieeyeklaaigvdntataskade..nvlknrYsnivaYDatrvkvtpneenkntDYinanfvpgykg.ekeyiatqgPvPaslvafWqmvweqkvsaiv

MLTNLVGLNKTKCHKYWPDKT--ETYGGVTVTLHQSEVFAGYENCTFILsKEKRSGSRIVRQFHFTVWPDKGVPQYATAVLAFRRKV-RALNPRDAGPVI
|.|. .  .| |||.||||..   .|| |||. ...|  | | . .| | ... . .| |.|...| |||.|||. ....| ||..| .. ...   |..
mvtreieagklkChrYWPddnselkygdvtvkstaeeekatyierkfkl.eresgetreveqlaytaWPdhGvPattkellefrkevlkltekktkaplv

VHCSVGVERTGAYIVIDAMLEQAK-KSRTVDIRNYLIAIRKHRPHMVQTKEQYSFIHSAVLEALT
.||| || |||.|| .| ...... . ...|... .  .||.|  ||||  ||.|.. |||.|| 
ihCsaGvGrtGtyialDrlvkaveaeleeldvkavvaelrkernlmvqtvvqyefvykavldald

0047943 (Phosphotyrosine protein) phosphatases II 126-391 2.7e-83 274.9 In-house 7-272 (273) alignment
Range on Protein: 126-391
Range on HMM: 7-272/273.0
KMHGGIRLETEYKKFNNGQQfPWGAARKPANKNKNKNRYANIVAYDHSRVVLervnGDEDLDYINASFIHGYDGTPRsFIASQGPLPPAFEGFWRMVWEQ
|. |  .|. |.... . .  ..        .||.|||| .|..||||||.|    ||.. ||||||.. ||. ... ||| |||||  .| ||||||||
kllgltllleefelllslkp.lltysvallpenkdknrykdilpydhsrvkl....gdggsdyinAsyvdgynlkrk.fiatqgPlpntvedfwrmvweq

NSQSIVMLTNLVGLNKTKCHKYWPDK----TETYGGVTVTLHQSEVFAGYENCTFILSKEKRSGSRIVRQFHFTVWPDKGVPQYATAVLAFRRKVRALNP
|.. |||||.|| |.. ||..|||..    ..||| .||||   |....|   |..|.. . . ||.|..||.| ||| |||.. . .| | ..||  . 
nvrviVmLtelvelgrekcaqYwpleggelsltygkftvtllseetkddytvrtleltnlgtgesrtvthfhytgwpdhgvppslesllefielvrkale

R--DAGPVIVHCSVGVERTGAYIVIDAMLEQAKKSRTVDIRNYLIAIRKHRPHMVQTKEQYSFIHSAVLEAL
   . |||.|||| || |||..|..| .|.| .| ..||. ...  .|..||.|||| ||| |.. |.|| |
alpsngpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrflyealleyl

subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 114-411 3.3e-83 274.3 In-house 3-303 (305) alignment
Range on Protein: 114-411
Range on HMM: 3-303/305.0
PIPIALFPEYV--AKMHGGIRLETEYKKFNNGqQFPWGAARKpaNKNKNKNRYANIVAYDHSRVVLERVNGDEDLDYINASFIHGYDGTpRSFIASQGPL
.| .. . .|.  |...    ||..||.. .  . .    .|  ..||.|||...|. .|..|. |   . ..| ||||||...||..   ..|..||||
iialddlaayikearvysdkgleaqykslyee.eesidvgkk..eankaknrlkeitlldddriiltekeslddsdyinasyvdgykrk.kkyivaqgPl

PPAFEGFWRMVWEQNSQSIVMLTNLVGLNKTKCHKYWPDKTET---YGGVTVTLHQSEVFAGYENCTFILSK-EKRSGSRIVRQFHFTVWPDKGVPQYAT
.   . |||...|   ..|||||.||  .| ||..|||...     .| ..|.|.... ...| .  . .|. .. . || | |...| |||.||||.||
kntvadfWrliveekvstivmltklveggkdkCrqYWpesktekkefgefsvelksektasdyieRklkisiededkesrtvlqyqltdWPdhGvpqfat

AVLAFRRKVRALNPRDAG-PVIVHCSVGVERTGAYIVIDAMLEQAKKSRTVDIRNYLIAIRKHRPHMVQTKEQYSFIHSAVLEALTCGNTEIQSEKYNQA
..| . ..|.    .| | |..|||| || |||..|..| .||..||  .||. ..| ..|..|. ||||..|| |.| |. | .|||.|.|  . .. .
sllslikrvqkdqkkdkgvpllVhCsagvgRtGvfiavdialerlkkEevvdvfevlkqlRskrmkmvqtldqYvflhdaldelitcgdtsiigsnlrar

MQKLA
..|| 
vnklk

subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 442-622 8.5e-82 269.1 In-house 1-182 (250) alignment
Range on Protein: 442-622
Range on HMM: 1-182/250.0
KSVGEKPQNLHKNRFSDIIALNSCRVMLHKEHADEESDYINAVFLHAHRGRNAFIATQHPLLETVEDFWRMVTDYDIGTIVMLNNLHDQVAPeSSEYWPD
|||..||||..|||..|||||.|.||.|.||..|.|||||||.|||....|.||||||.|| .|.|||||||.....||||||.||...     ..||| 
ksvakkpqnkeknryadiialdssrvvLekekgdkesdyinasflhgyderkafiatqgPlqatiedfWrmvleeksgtivmLtnLkesekt.yhqywPv

HGATKYGHIGISVLSKQKKGDVICVKPKVTRKKKTHE--VRHLHHVSWTDKCIPKVSRSVLDLLDEVQTSQQQCGNVPVLVQC
 .|.|||.. .|.|||....|..  | |....||..|  ||.||.|.| ||..|.| ..||.||..||.||||.|| ||.|||
ekaekyGdvtvsllskeefadytkrklklskakkaderivrqlhfvvWPdkgvPevatavLellkkvqasqqqagnaPvivqC

0045450 (Phosphotyrosine protein) phosphatases II 128-391 1.1e-80 266.9 In-house 24-304 (307) alignment
Range on Protein: 128-391
Range on HMM: 24-304/307.0
HGGIRLETEYKKFNNGQQF-PWGAARKPANKNKNKNRYANIVAYDHSRVVLERVNGD-EDLDYINASFI--------HGYDGtPRSFIASQGPLPPAFEG
 .  .|. |..|... . | ..        .||.|||| .|..|||.||.|  ..|. || ||||||..        .|||  .| ||| |||||  .| 
dfltgllkefekllsvtvfllgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydl.krkfIatqgPlpetved

FWRMVWEQNSQSIVMLTNLVGLNKTKCHKYWPDK--TETYGGVTVTLHQSEVFAGYENCTFILSKE-KRSGSRIVRQFHFTVWPDKGVPQYATAVLAFRR
||||.|||... |||||.|| |.. ||..||||.  . ||| .||||   |. .||   |. ..   . . ||.|..||.| ||| |||..   .|.| .
FwrmlweqgvtvivmltelvelgrekcaqywPdegeeltygnftvtllseehldgytvrtlevtdldgtgesrtvthfhytgwpdhgvppsfeelldfie

KVRALNPR--DAGPVIVHCSVGVERTGAYIVIDAMLEQAKKSRT---VDIRNYLIAIRKHRPHMVQTKEQYSFIHSAVLEAL
.||. . .  . |||.|||| || |||..|... ||.| .|  |   ||... .  .|..||..||. ||| |.. |.|| |
evrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyeallell

subfamily_Ptp69D_pd Subfamily Ptp69D 132-410 3.4e-80 264.4 In-house 23-305 (307) alignment
Range on Protein: 132-410
Range on HMM: 23-305/307.0
RLETEYKKFNNGqQFPWGAARKPANKNKNKNRYANIVAYDHSRVVLERVNGDEDLDYINASFIHGYDGTpRSFIASQGPLPPAFEGFWRMVWEQNSQSIV
 |. ||.| ..  ...  .     . |. |||| .|.|.|. ||.|...||.|| ||||||||.||. . ..|||.|.|.    . ||||..||... ||
glakeyekLear.eidkstkvsekkenalknRyedikafDktRvkLkkingkedsdYinasfikgykek.kkfiaaqdPveatigDfWRmiaeqevtliv

MLTNLVGLNKTKCHKYWP-DKTETYGGVTVTLHQSEVFAGYENCTFILSKEKRSG-----SRIVRQFHFTVWPDKGVPQYATAVLAFRRKVRALNPRDAG
||.||   |. ||.|||| ...  || . |.| ..|    | . .. .|| | ..     || | |.|.| |.|  ||. |...| . ..|| |.  . .
mlsnlteknrkkcakYWpiedevqygdilvklvseekhsdyiiReldvskkkeesgevedsrkvvqyhytgWkDskvPevargllklieqvrelyklnrs

PVIVHCSVGVERTGAYIVIDAMLEQAKKSRTVDIRNYLIAIRKHRPHMVQTKEQYSFIHSAVLEALTCGNTEIQSEKYNQAMQKL
|..|||| ||.|.| .. .| .|.| |.  .||| .    .|..|. .||  |||.|.. |.|.  . |.|... .....|...|
PivvhCsaGvgrsgifvaldsllqqlkaedkvdifetvkdLrsqRnllvqsleqYvflyralldyssygdtdedvddledaierl

DSPc_SM00195 134-391 6.6e-80 263.6 In-house 3-262 (263) alignment
Range on Protein: 134-391
Range on HMM: 3-262/263.0
ETEYKKFNNGQQFPwGAARKPANKNKNKNRYANIVAYDHSRVVLERVNGDEDLDYINASFIHGYdGTPRSFIASQGPLPPAFEGFWRMVWEQNSQSIVML
..|..| .. ..       .  .|||.|||| ||. |||.|| |.. ...|. |||||..| |.   ....|| |||||  .| |||||||.... ||||
keefekleestspk.etteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikga.nkkkkyIatQgPlpstvedFWrmvweekvkiivml

TNLVGLNKTKCHKYWPDK---TETYGGVTVTLHQSEVFA-GYENCTFILSKEKRSGSRIVRQFHFTVWPDKGVPQYATAVLAFRRKVRALNPRDAGPVIV
|. .  .|.||..|||..   .||.| ..|.| . |     ..  |. |.||... .| |.|.... |||.|||. .. ||.. |.|.  . .  ||..|
teeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkkskstssgpivV

HCSVGVERTGAYIVIDAMLEQAKKSRTVDIRNYLIAIRKHRPHMVQTKEQYSFIHSAVLEAL
||| ||.|||....|| .|.. ..  .||| . . ..||.||.||||.|||.||. |.||..
hCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi

PTPc_SM00194 134-391 6.6e-80 263.6 In-house 3-262 (263) alignment
Range on Protein: 134-391
Range on HMM: 3-262/263.0
ETEYKKFNNGQQFPwGAARKPANKNKNKNRYANIVAYDHSRVVLERVNGDEDLDYINASFIHGYdGTPRSFIASQGPLPPAFEGFWRMVWEQNSQSIVML
..|..| .. ..       .  .|||.|||| ||. |||.|| |.. ...|. |||||..| |.   ....|| |||||  .| |||||||.... ||||
keefekleestspk.etteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikga.nkkkkyIatQgPlpstvedFWrmvweekvkiivml

TNLVGLNKTKCHKYWPDK---TETYGGVTVTLHQSEVFA-GYENCTFILSKEKRSGSRIVRQFHFTVWPDKGVPQYATAVLAFRRKVRALNPRDAGPVIV
|. .  .|.||..|||..   .||.| ..|.| . |     ..  |. |.||... .| |.|.... |||.|||. .. ||.. |.|.  . .  ||..|
teeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkkskstssgpivV

HCSVGVERTGAYIVIDAMLEQAKKSRTVDIRNYLIAIRKHRPHMVQTKEQYSFIHSAVLEAL
||| ||.|||....|| .|.. ..  .||| . . ..||.||.||||.|||.||. |.||..
hCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi

subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 133-390 6.9e-80 263.2 In-house 23-278 (288) alignment
Range on Protein: 133-390
Range on HMM: 23-278/288.0
LETEYKKFNN-GQQFPWGAARKPanKNKNKNRYANIVAYDHSRVVLERVNGDEDLDYINASFIHGYDGTpRSFIASQGPLPPAFEGFWRMVWEQNSQSIV
.. ||..  . ...    |.|..  .|..|||| ||..||. || |. ..  .. ||||||.|.|.... . .||.||||. . . ||..|.|.... ||
fseeynsLaalektksvtagrla..vnakknRyrnilpyDekrvklkkleeeagaDYinasyidgekkk.kkyiatqgPladtvndfWelvyenktstiv

MLTNLVGLNKTKCHKYWPDKTE--TYGGVTVTLHQSEVFAGYENCTFILSkeKRSGSRIVRQFHFTVWPDKGVPQYATAVLAFRRKVRALNPRDAGPVIV
|||.||  .||||..||||. .   || ||||| .|.    . . ...|   |. . . . |.....|||.|||. .. .|...|.|   |. |.||.||
mltelveggktkCeeYWPdadkpknyGsvtvtlveskeledfvlrkllle..kkkteleitqyqylaWpdhgvPeskapllellrqvkvanqadtgpiiv

HCSVGVERTGAYIVIDAMLEQAKKSRTVDIRNYLIAIRKHRPHMVQTKEQYSFIHSAVLEA
||| || ||| .|..||.... ... ..|. . .  .||.|. .|||..|| ||....|. 
hCsaGvGrtgtFialdalidaveeedyiDvagtvaklRkqRallvqtlkqYefiyevllsl

subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 114-434 5.5e-78 257.3 In-house 1-319 (515) alignment
Range on Protein: 114-434
Range on HMM: 1-319/515.0
PIPIALFPEYVAKMHGGIRLETEYKKFNNGQQFPWGAARKPAnkNKNKNRYANIVAYDHSRVVLERVNGDEDLDYINASFIHGYDGtPRSFIASQGPLPP
|.|.| || .|.|      .  |.. .   . .|   |..    | .|||| ||. || .|| || .| . . ||.|||.|...|   ...||||||.. 
plplaqfPafvnknrhttlfseefhdlpgpniypqtvaqeei..nfkknryknilPydsvrvklevindnPhsdyfnasyipsfdn.dkayiasqgPnka

AFEGFWRMVWEQNSQSIVMLTNLVGLNKTKCHKYWPD---KTETYGGVTVTLHQSEVFAGYENCTFILSKEKRsgSRIVRQFHFTVWPDKGVPQYATAVL
. . |||.|...|   |.|.|.|   .| || |||||   ..  .| . | |   |  .|    .. . |..   || | ||||| |||||||. ....|
svddfWrlvlqenvttiamvtklkegdkikcgkyWPdkpgdsvkfGsikvelvsleactggikrkltvlkgdd..srtvtqfhfteWPdkGvpkhtssll

AFRRKVRALNPRDAGPVIVHCSVGVERTGAYIVIDAMLEQAKKSRTVDIRNYLIAIRKHRPHMVQTKEQYSFIHSAVLEALTCGNTEIQSEKYNQAMQKL
 . ..|.| . . . |.|.||| || ||| .| || .. .||..|.||. |..  ||..||..|||.|||.||. |||| |   || |   .. . .| |
klikevkadhgqythpliihcsaGvGrtGvvisidsvvahakttrmvdvfnfvtnirqkrpylvqtqeqyafiygavledllwrntlipvihftdhlqdl

ASVNGKFPMTGYALEFQRLNSVTS
 |       .  . ||| |.|.. 
hssgdgrgrskmtkefqtlkslcp

subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 113-415 2.5e-77 254.8 In-house 1-301 (315) alignment
Range on Protein: 113-415
Range on HMM: 1-301/315.0
KPIPIALFPEYVAKMHGGIRLETEYKKFNNGQQFPWGAARKPANknKNKNRYANIVAYDHSRVVLERVNGDEDLDYINASFIHGYDGtPRSFIASQGPLP
.|||.| || .| | .    .  |.. . . . ..  .||.. |   .|||| ||. .|..||.|| .. . | ||||||.|...|   ...|||||||.
qpipvaqfpafvnknrhtalfseefhdlpdPdiyrqrvaretin..fkknryknilPldsarvkleviddsPdsdyinasyiksvdd.dkayiasqgPlk

PAFEGFWRMVWEQNSQSIVMLTNLVGLNKTKCHKYWPD---KTETYGGVTVTLHQSEVFAGYENCTFILSKEKrsGSRIVRQFHFTVWPDKGVPQYATAV
 . . |||||....  .|||.|..   .| || .||||   ..  .| . |.| . |  ..  .  ... | .   || | ||.|| ||||||.. ....
asvddfwrmvlqekvttivmvtkkqegdkikcrqywPdrkadsvefGsikvellsleadtdgvarklvtrkse..esrtvtqfqftewPdkGvdkqtssl

LAFRRKVRALNPRDAGPVIVHCSVGVERTGAYIVIDAMLEQAKKSRTVDIRNYLIAIRKHRPHMVQTKEQYSFIHSAVLEALTCGNTEIQSEKYNQAMQK
| . ..|.| | ..  ...|||| || |||  | || ...|.|..|.||. |..  .|..||..|||.|.|.||. |||| |   || |   .. . .| 
lklikevkadngkkefsllvhcsaGvGrtGvvisidevvaqikrtrsvdvfnfvknlrakrpylvqteeeyafiydavledllwrntlilvihftdhlqd

LASVNG
| .  .
lhtsvd

Y_phosphatase Protein-tyrosine phosphatase 158-389 6.2e-77 253.5 Pfam-A 1-235 (235) alignment
Range on Protein: 158-389
Range on HMM: 1-235/235.0
NKNKNRYANIVAYDHSRVVLERVNGDEDldYINASFIHGYDgTPRSFIASQGPLPPAFEGFWRMVWEQNSQSIVMLTNLVGLNKTKCHKYWP---DKTET
||.|||| .|..||..|| |.  .|..|  ||||....||. ....|||.||||.  .| ||||||......|||||.|.  ...||..|||   ....|
nkkknRykdilpydktrvklkgsegpsd..YInAnyvkgyk.ekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeeslt

YGGVTVTLH-QSE-VFAGYENCTFILSKEKRS-GSRIVRQFHFTVWPDKGVPQYATAVLAFRRKVRALNPRDAGPVIVHCSVGVERTGAYIVIDAMLEQA
|| ..|.|  ...   ..|   .. |.|.|..  .|.|.|.|.| |||.|||. ....| . |||.  .  . |||.|||| ||.||| ....|..|||.
ygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleql

KKSRTVDIRNYLIAIRKHRPHMVQTKEQYSFIHSAVLE
.. ..||. ...  .||.||.|||. ||| |.. |.||
eaeeevdvlqivkelRkqRpgmvqsleqYiflykaile

Y_phosphatase Protein-tyrosine phosphatase 158-389 6.2e-77 253.5 In-house 1-235 (235) alignment
Range on Protein: 158-389
Range on HMM: 1-235/235.0
NKNKNRYANIVAYDHSRVVLERVNGDEDldYINASFIHGYDgTPRSFIASQGPLPPAFEGFWRMVWEQNSQSIVMLTNLVGLNKTKCHKYWP---DKTET
||.|||| .|..||..|| |.  .|..|  ||||....||. ....|||.||||.  .| ||||||......|||||.|.  ...||..|||   ....|
nkkknRykdilpydktrvklkgsegpsd..YInAnyvkgyk.ekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeeslt

YGGVTVTLH-QSE-VFAGYENCTFILSKEKRS-GSRIVRQFHFTVWPDKGVPQYATAVLAFRRKVRALNPRDAGPVIVHCSVGVERTGAYIVIDAMLEQA
|| ..|.|  ...   ..|   .. |.|.|..  .|.|.|.|.| |||.|||. ....| . |||.  .  . |||.|||| ||.||| ....|..|||.
ygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleql

KKSRTVDIRNYLIAIRKHRPHMVQTKEQYSFIHSAVLE
.. ..||. ...  .||.||.|||. ||| |.. |.||
eaeeevdvlqivkelRkqRpgmvqsleqYiflykaile

subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 133-410 2.6e-76 252.0 In-house 36-310 (319) alignment
Range on Protein: 133-410
Range on HMM: 36-310/319.0
LETEYKKFNNGQqfPWGAARKPA--NKNKNKNRYANIVAYDHSRVVLERVNGDEDLDYINASFIHGYDgTPRSFIASQGPLPPAFEGFWRMVWEQNSQSI
|| |...  .    . .| .. |  ..||.|||. ||.|.|...| |||..| |  |||||||. ||   .  .||.||||. . . ||||.||.|. .|
levefrracklg..vnladqtfanldqnkdknriinilafdknvvklerliGeefsdyinasfvtGyq.rkdkyiaaqGPldntladfWrmiweyncsti

VMLTnlvglnKTKCHKYWPDKT-ETYGGVTVTLHQSEVFAGYENCTFILSK-EKRSGSRIVRQFHFTVWPDKGVPQYATAVLAFRRKVRALNPRDAG--P
|.||      | || .||| |. ....   | ..  |  | |    . ||.  |  . | ..||||  |||.|||.|.. .. . .||| |. .  .  .
vllt......kdkcsqywplkivikeerfkvkvdsveetaeyvvrdielsedgkekdirkitqfhflGwpdvGvpdypsdlmrlvkkvrhltskenhran

VIVHCSVGVERTGAYIVIDAMLEQAKKSRTVDIRNYLIAIRKHRPHMVQTKEQYSFIHSAVLEALTCGNTEIQSEKYNQAMQKL
..|||| || |||.|||.|..|.. |. . ||. |..  .|. |...||   || ||.||.||    |....    .   ...|
ivvhcsaGvGrtGvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalleehlfghsdvampdfpayleel

0040439 (Phosphotyrosine protein) phosphatases II 157-391 4.1e-76 251.1 In-house 10-246 (249) alignment
Range on Protein: 157-391
Range on HMM: 10-246/249.0
KNKNKNRYANIVAYDHSRVVLERVNGDEDLDYINASFIHGYDGTPRsFIASQGPLPPAFEGFWRMVWEQNSQSIVMLTNLVGLNKTKCHKYWP-DKTETY
.||.|||| .|..||||||.|. ..| .. ||||||.|.||. ..| ||| ||||| ..| ||||.||.....|||||.|| |.. ||..||| ... .|
enkdknrypdilpydhsrvklsilpglflsdyinAsyidgyyikrr.fiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywplggsley

GGVTVTLHQSEVFAGYENCTFILSKEKRSGSRIVRQFHFTVWPDKGVPQYATAVLAFRRKVRALNPR--DAGPVIVHCSVGVERTGAYIVIDAMLEQAKK
|..|||| . ||...|   |. |.. . . || |.....| ||| |||..   .|.| ..||  . .  . |||.|||| || |||..|... |||| .|
gdftvtllsvevkddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaaylmleqlek

SRTVDIRNYLIAIRKHRPHMVQTKEQYSFIHSAVLEAL
 ..||. ...  .|..||..||. ||| |.. |.|| |
elgvdleeavkllrsqRpgavqnpeqyrflyeallell

0042113 (Phosphotyrosine protein) phosphatases II 157-390 2.9e-75 248.1 In-house 8-242 (245) alignment
Range on Protein: 157-390
Range on HMM: 8-242/245.0
KNKNKNRYANIVAYDHSRVVLERVNGDEDLDYINASFIHGYDGTPRsFIASQGPLPPAFEGFWRMVWEQNSQSIVMLTNLVGLNKTKCHKYWP-DKTETY
.||.|||| .|..|||.||.|  ..||.|.||||||...||. ||. |||.|||||  .| ||||.||.....|||||... |.. ||..||| . . ||
enkdknrysdilpydhtrvklspdggdldsdyinasyvdgyritpk.fiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywplgeslty

GGVTVTLHQSEVFAGYENCTFILSKEKRSGSRIVRQFHFTVWPDKGVPQYATAVLAFRRKVRALNP-RDAGPVIVHCSVGVERTGAYIVIDAMLEQAKKS
|..||||   |....|   |. ..... . || |...|.. ||| ||| .   .| | . ||      . |||.|||| || |||..|... ||||..| 
gdftvtllseehlddytvrtlevtnlgddesrevihyhylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylmleqleke

RTVDIRNYLIAIRKHRPHMVQTKEQYSFIHSAVLEA
..|.. . .  .|..||..||| .|| |.. |.|| 
lgvsleeavkelrsqRpgavqtpsqyrflyeallel

subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 156-410 5e-75 247.6 In-house 23-274 (284) alignment
Range on Protein: 156-410
Range on HMM: 23-274/284.0
NKNKNKNRYANIVAYDHSRVVLERVNGDEDLDYINASFIHGYDgTPRSFIASQGPLPPAFEGFWRMVWEQNSQSIVMLTnlvglnKTKCHKYWPDKT-ET
..||.|||. .|.|.|...| |||. | |  |||||||| ||   .  .||.||||. . . ||||.||.|. .||.||      | || .||| |. ..
dqnkdknrighilafdknvvklerliGeefsdyinasfitGyq.rkdkyiatqGPldntladfWrmiweyncstivllt......kdkcsqywplkivik

YGGVTVTLHQSEVFAGYENCTFILSK-EKRSGSRIVRQFHFTVWPDKGVPQYATAVLAFRRKVRALNPRDAG--PVIVHCSVGVERTGAYIVIDAMLEQA
..   | ..  |  . |    . ||.  |  . | .|||||  |||.|||.|.. .... .||| |. .  .  ...|||| || |||.|||.|..|.. 
eerfkvkvdsveeseeyvvrdielsedgkekdirkirqfhflgwpdvgvpdypsdlmrlvkkvrhltskenhranivvhcsagvgrtgvyivldvlldrm

KKSRTVDIRNYLIAIRKHRPHMVQTKEQYSFIHSAVLEALTCGNTEIQSEKYNQAMQKL
|. . ||. |..  .|. |...||   || ||.||.||    |....    .   ...|
keekqvdvynfvrdlrqqrntlvqdlvqykfiysalleehlfghsdvalpdfpayleel

subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 113-403 1.9e-74 245.5 In-house 8-296 (297) alignment
Range on Protein: 113-403
Range on HMM: 8-296/297.0
KPIPIALFPEYVAKMHggiRLETEYKKFNNGQQFPWGAARKPANK-NKNKNRYANIVAYDHSRVVLERVNGDEDLDYINASFIHGYDGtprSFIASQGPL
.|||.. |. .| | .   . . ....|.   .    .. .  .| | .|.||.||. || ||| |. || | | ||.||||..|.      .|..| | 
rpiplsdfatlvqknr...htdvfseeflclpeaniqpqtvaekkvnfeksRYkniLPydssRvkLaivnddpdsDyvnasfvkgnkh...rlittqmPm

PPAFEGFWRMVWEQNSQSIVMLTNLVGLNKtKCHKYWPDKT-ETYGGVTVTLHQSEVFAGYENCTFILSKEKRSGSRIVRQFHFTVWPDKGVPQ--YATA
. . . ||.||.... . ||||...   .| || .||.||.  |.| |.|.|.  .   |. . .. ..|.|    |.|.|..|. |||| |..   |..
katvadfWamvldeqvstivmlnddnerdk.kcaryWsdkgvttfGdvsvvllsvsereGfikrelevtkgkakarrvvkqyqfveWPdkaverkdsass

VLAFRRKVRALNPRDAG-PVIVHCSVGVERTGAYIVIDAMLEQAKKSRTVDIRNYLIAIRKHRPHMVQTKEQYSFIHSAVLEALTCGNTEIQSEKY
.| .   ||      |  |..|||. || ||| .. || .. .||.  .||| ...  .|..||..|||||||.|.. |||||| . .|.||.. .
llklisevrkdfsqnaegPllvhclaGvGrtgvlltidsvvaeakrekevdifglvkklrqerpylvqtkeqykfvyvavleallsedtriqasyf

0045098 (Phosphotyrosine protein) phosphatases II 157-394 3.4e-74 245.0 In-house 32-275 (278) alignment
Range on Protein: 157-394
Range on HMM: 32-275/278.0
KNKNKNRYANIVAYDHSRVVlervngdedlDYINASFIHGYdgtPRSFIASQGPLPPAFEGFWRMVWEQNSQSIVMLTNLVGLNKTKCHKYWPDKT-ETY
.|..|||| .|..||||||.          ||||||.|.||   |. ||| |||||  .. ||||.||.....|||||.|| |.. ||..|||..  .||
gnldknRykdilpydhsrVk..........dYINAsyidgy...pkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrekcaqywpeggslty

GGVTVTLHQSEVFAGYENCTFILSKE----KRSGSRIVRQFHFTVWPDKGVPQYA--TAVLAFRRKVRALNPR-------------DAGPVIVHCSVGVE
|..|||| . ||.  |  .|...       .   || |...|.. ||| ||| .   . .| . . .|. . .             . |||.|||| || 
gdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsggpvlVHCsaGvg

RTGAYIVIDAMLEQAkkSRTVDIRNYLIAIRKHRPH-MVQTKEQYSFIHSAVLEALTCG
|||...... |||.    ..||. ...  .|..||. .||..||| |.. ..|| | .|
RtGtlvaaylmlell..eggvdlleavkelrsqRpglavqnleqyrflyefllelllrg

subfamily_PTPN6_pd Subfamily PTPN6 151-390 4.5e-72 237.6 In-house 49-296 (306) alignment
Range on Protein: 151-390
Range on HMM: 49-296/306.0
ARKPanKNKNKNRYANIVAYDHSRVVLErVNGDEDLDYINASFIH-GYDGTPRSFIASQGPLPPAFEGFWRMVWEQNSQSIVMLTNLVGLNKTKCHKYWP
..||  .||.|||| ||. .||.||.|.  ..  . |||||..|.    |. .|.||.|| |.   . ||||||..||. |||.|. |  .| || .|||
gakp..enkeknryknilPfDhtrvilk.epsvpgsdyinanyikkevkgsdksyiatqgclettvsdFWrmvwqensrvivmttkevErgkekCarYWP

DKT--ETYGGVTVTLHQSEVFAGYENCTFILS-KEKRSGSRIVRQFHFTVWPDKGVPQYATAVLAFRRKVRA----LNPRDAGPVIVHCSVGVERTGAYI
|..  |.|| ..||  ...  | |.  .. .| |.| . .| |.|.||..|||.|||.   |||.| ..|..    |. ..|||..|||| |. |||..|
deeekeeyGkisvtnvseksladYilRelsvskkkkkkeerevfqyhfksWPdhgvpkdpgavLdfledvnrkqeeleeaeagpivvhCsaGiGRtGtfi

VIDAMLEQAKKS---RTVDIRNYLIAIRKHRPHMVQTKEQYSFIHSAVLEA
|||..|.. .|.     .||..    .|..|  .|||..|| |.. |. . 
viDillkliekkgldadidiqklvksvreqrsglvqteqqykfvykaikky

subfamily_PTPN12_pd Subfamily PTPN12 133-392 5.6e-72 237.1 In-house 17-278 (290) alignment
Range on Protein: 133-392
Range on HMM: 17-278/290.0
LETEYKKFNNGQQFPWGAARKPanKNKNKNRYANIVAYDHSRVVLERVNGDEDLDYINASFIHGYDGTpRSFIASQGPLPPAFEGFWRMVWEQNSQSIVM
| .. .|. . ....  |..|.  .|..|||| .|. ||.|||.|.. ...|. |||||.||.| .|.  ..||.||||| . . ||||.||.| . .||
lkklsekykaekvysteageke..envkknrykDilPydksrvelskieeeegsdYinanfikgvegk.leyiaaqgPLpktlddfWrmiweknveivvm

LTNLVGLNKTKCHKYWPDKT---ETYGGVTVTLHQSEVFAGyENCTFILSKEKRSGSRIVRQFHFTVWPDKGVPQYATAVLAFRRKVRALNPRDAGPVIV
. ..| |.|.||..|||...    ..| ..|||.. . .   .     |  |... ||.|.|||.| |||.|||. |. .|.. ..|| |. ... |..|
aCrevelgkkkCerYWpeegeeelefgefevtleeekavdd.dflirtLkveaqkesrkvyqfhYtaWPDhgvPssaksllelielvrelqesedaPlvv

HCSVGVERTGAYIVIDAMLEQ---AKKSRTVDIRNYLIAIRKHRPHMVQTKEQYSFIHSAVLEALT
||| || |||. |.|| . |.    | . ..|. . .. .||.|. .|||||||.... ||.| ..
hCsaGvGrtGtiiaidyvrellkaekipeeldvfdlvlelrkqraalvqtkeqyelvykavaelvq

0037934 (Phosphotyrosine protein) phosphatases II 157-389 3.2e-69 228.5 In-house 9-240 (243) alignment
Range on Protein: 157-389
Range on HMM: 9-240/243.0
KNKNKNRYANIVAYDHSRVVLervngdEDLDYINASFIHGYDgtpRsFIASQGPLPPAFEG----FWRMVWEQNSQSIVMLTNLVGLNKTKCHKYWPDKT
 |..|||| .|..||||||.|      |. |||||..| ...   | .||.|||||  .|     ||||.||.....|||||.|| |.. ||..|||...
enlsknrysdilpydhsrvkl......egsdyinanliyvtp...r.liatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywpgev

eTYGGVTVTLHQSEVFAGYENCTFILSKEK-RSGSRIVRQFHFTVWPDKGVPQYATAVLAFRRKVRAL--------NPRDAGPVIVHCSVGVERTGAYIV
 |||..|||| ..|....|   |. |.  .    .| |...|.. ||| |||.  . .|.| ..||.         .  . |||.|||| || |||..|.
.tygdftvtllseehlddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRtGtlia

IDAMLEQAkksrTVDIRNYLIAIRKHRPH-MVQTKEQYSFIHSAVLE
.. ||..     .||. ...  .|..||. .||| .|| |.. |.||
aylmllll....gvdleeavkllreqRpgkavqtpsqyrflyealle

subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 113-416 8.1e-68 223.6 In-house 2-262 (392) alignment
Range on Protein: 113-416
Range on HMM: 2-262/392.0
KPIPIALFPEYVAKMHGGIRLETEYKKFNNGQQFPWGAARKPANknKNKNRYANIVAYDHSRVVLERVNGDEDLDYINASFIHGYDGTpRSFIASQGPLP
.|||.| || .| | .    .  |.. . . . .|  .|.|. |  ..|||| ||. || .||.|| ..   | ||.|||.|...|   ...|||||| .
qpipvaqfpafveknrhsalffeefhdlpgpdiypqtvaqkein..lkknryknilpydsarvkleviddipdsdylnasyipsfdne.kayiasqgpna

PAFEGFWRMVWEQNSQSIVMLTNLVGLNktkchkywpdktetyggvtvtlhqsevfagyenctfilskeKRSGSRIVRQFHFTVWPDKGVPQYATAVLAF
 ... |||||...|  .|.|.|.|   .                                         |    | | ||||| ||||.||......| |
aslddfwrmvfqenvttiamvtklkegd.........................................kgddartvaqfhftewPdkdvpkhtssllkf

RRKVRALNPRDAGPVIVHCSVGVERTGAYIVIDAMLEQAKKSRTVDIRNYLIAIRKHRPHMVQTKEQYSFIHSAVLEALTCGNTEIQSEKYNQAMQKLA-
 ..|.|   . . |.|.||| || |||  | ||... .|||.| ||. |..  ||..||.||||||||.||. |||| |   || |   .. . .|.|  
ikevkadfGqythpliihcsagvgrtgvvisidsvvahakktrmvdvfnfvtnirrkrpymvqtkeqyafiygavledllwrntlipvvhftdhlqdlst

SVNGK
|..|.
ssdGd

subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 156-389 4.2e-67 221.1 In-house 26-266 (274) alignment
Range on Protein: 156-389
Range on HMM: 26-266/274.0
NKNKNKNRYANIVAYDHSRVVLERVNGDE-DLDYINASFIHGYDGTPRSFIASQGPLPPAFEGFWRMVWEQNSQSIVMLTNLVGLNKTKCHKYWPDKTET
 ....|||| .|.  ..|||.||. .... |..|||| .|.|||.. . ..| ||||| . . ||||......| |||||.|   |..||..|.||....
fgsqtknryktilPnensrvllesessededssyinanyikGydeeskayvatqGPlpntvadfWrmiyqeevqvivmltklkeaneqkCavyfPdaedy

-----YGGVTVTLHQSEVFAGYENCTFILSKEKRsgSRIVRQFHFTVWPDKGVPQYATAVLAFRRKVRALNPR---DAGPVIVHCSVGVERTGAYIVIDA
     ||.| .. ..     .|.  ...|.. .|  .| |  . .| |||. .|. |...| . ..|.  . .    ..||.|||| |. |||..| |. 
eiserygdveikvekiverndysvrklvlkyler..ersvkhywytdWPdhksPddantlldlvleveesreeenaklapvvvhCsaGiGrtGcfiaisi

MLEQAKKSRTVDIRNYLIAIRKHRPHMVQTKEQYSFIHSAVLE
 . | ... .||. .    .| .|  ||||.||| .|| |. .
avrqlreeivvdvlkivcnlrldrGGmvqtseqyelihralcl

subfamily_PTPN9_pd Subfamily PTPN9 133-389 4.3e-67 221.2 In-house 18-288 (297) alignment
Range on Protein: 133-389
Range on HMM: 18-288/297.0
LETEYKKFNNGQqfPWGAA-RKPANKNKNKNRYANIVAYDHSRVVLERVNGDEDLDYINASFIHGYDgTPRSFIASQGPLPPAFEGFWRMVWEQNSQSIV
|  ||..  | .  . | . .   . | .||||.... ||..||||..|..||  |||||.|. ||   ...||| ||||. ... ||||||||.   ||
lskeyaeirnep..veGtflasklranleknrytdvlcydetrvvlakvdedeasdyinanfvdGyk.qkkafiatqGplkktvsdfWrmvWeqevlviv

MLTNLVGLNKTKCHKYWP---DKTETYGGVTVTLHQSEVFAGYENCTFILSKEKRSGSRIVRQFHFTVWPDKGVPQYATAVLAFRRKVRA--------LN
| | .|   . || .|||   .... .| ..|.  . |.   |.  .. ... | . || |  | |. ||| |||. |...| ...|||         | 
mttrvvergrlkcgqyWpleeessaefgdlsvsnveveeeedykvrvleiknvkteesrkvthfqflsWPdyGvPssaaslldvlekvrekqalavkelg

PRDA-----GPVIVHCSVGVERTGAYIVIDAMLEQAKKSRTVDIRNYLIAIRKHRPHMVQTKEQYSFIHSAVLE
....      |..|||| |. |||..| .|  |.. ..  |||... .  .|. | ...|| ||| | . ||||
dewkghpsgPPivvhcsaGiGrtGtfitldiclsrleevgtvdvvetvkllrtqrafsiqtpeqyefcylavle

subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 149-420 7.8e-67 220.7 In-house 41-314 (325) alignment
Range on Protein: 149-420
Range on HMM: 41-314/325.0
GAARKPANKnkNKNRYANIVAYDHSRVVLERVNGDEDLDYINASFIHGYDGTpRSFIASQGPLPPAFEGFWRMV--WEqnsQSIVMLTNLVGLNKTKCHK
 .| ||.||  .|||. |.||.|.||||||  . | . ||||||... . .    |.|.| ||. . . .||.|  |.    |.|...| . |.| .| .
kvamkpenk..aknrfknvvaldksrvvletkkddpssdyinasylrddkkk.dvflaaqaPltatindlWrlvldWr...csvvvvlneldlgkdrcav

YWPDK---TETYGGVTVTLHQSEVFAGYENCTFILSKEKRSGSRIVRQFHFTVWPDKGVPQYATAVLAFRRKVRAL------NPRDAGPVIVHCSVGVER
|||..   . |.||. | |   | .. |    . . . |.  .| |.||..  |.| ||... ...... . | |.      | . ..|..|||| || |
ywpkemgksktfGglevklrtieeisdyvhrvldvkqvkkGetrsvkqfqlqswddmGvqkrpatlisilqlvkavservtantkastpilvhcsaGvGr

TGAYIVIDAMLEQAKKSRTVDIRNYLIAIRKHRPHMVQTKEQYSFIHSAVLEALTCGNTEIQSEKYNQamqKLASVNGKFPMT
||..| . ..|..  .   ||| ...  .||.|| ||.| .||..|. |. ||. .|||..    ..    ||.|.. . |.|
tGvfislysalakvieesrvdifgfvkklrkdrpsmvetvdqyiliyealveaymsgntdvpvssfea...klsslqernplt

subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 115-395 1e-66 219.8 In-house 2-287 (290) alignment
Range on Protein: 115-395
Range on HMM: 2-287/290.0
IPIALFPEYVAKM--HGGIRLETEYKKFNNGQQfPWGAARKPANKNKNKNRYANIVAYDHSRVVLERVNGDED--LDYINASFIHGYDGTpRSFIASQGP
||.  | |.||.   .|  . ....|....|.. .  . .. ...||..||.|||| ||  |..| ...|..|   .||||..|.||    ...|| |||
ipvdkfgefvanghakgnegfrnqfkmldsges.ehtvtvgltssnkllnRfanivvyddnritLrpisghkDCtneyinAcyikgykek.kqyiatqgp

LPPAFEGFWRMVWEQNSQSIVMLTNLVGLNKTKCHKYWPDK-TETYGGVTVTLHQSEVFAGYENCTFILSKEKR-SGSRIVRQFHFTVWPDKG-VPQYAT
..     ||...|....  |||||| .  .|.||..||||. |..|| ....|.. |.. .| . .. . ...    ...| |...| |...| |....|
vsntlvdFWkliwqekvtiivmltniieegkvkCqqYWpdsdtkaygefsikllneetlneyierklevknknsagakqsvtqyqitnwdstgkvtnpqt

AVLAFRRKVRALNPRDAGPVIVHCSVGVERTGAYIVIDAMLEQAKKSRTVDIRNYLIAIRKHRPHMVQTKEQYSFIHSAVLEALTCGN
 .|.... ..    |  ....|||| .| |.. .....  ....|.   .|. . |   |  .| .|||..|| .|.. ||..|.. .
illvieemyktqrkrgntsivvHCSdtvgrsavfcaaattinkcktegvidvfqvlksqRiqkpgsvqtvqqyqgifqivltyldsfe

subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 115-398 3.4e-66 218.2 In-house 2-285 (287) alignment
Range on Protein: 115-398
Range on HMM: 2-285/287.0
IPIALFPEYVAKMH--GGIRLETEYKKFNNGQQFPWGAARKPANKNKNKNRYANIVAYDHSRVVLErvngDEDLDYINASFIHGYDGTpRSFIASQGPLP
||.  | |.||| |  |    .. .. ... .| .     . |..||.|||...|. .|  ||.|.    .|. |||||.|| ||    . ||....|. 
ipvekfgefvakghakgnegfknqftvleqvtqredevthniasqnkdknRltqilvpdnyrvllk....gehpdyinavfidgykek.kafiiaesPmf

PAFEGFWRMVWEQNSQSIVMLTNLVGLNKTKCHKYWPDKT-ETYGGVTVTLHQSEVFAGYENCTFILSKEKRSG-SRIVRQFHFTVWPDKG-VPQYATAV
 .   ||......| . ||||...   .. .|..|||...  ..|  ...| . || ||| . .. . .....|  . |.|...| |...| |....| .
ntarnfWkliddrnvtaivmlcqekendeevcyqyWpeeksvvlGeyniellneevnagyierklevknknkagdkqqvkqyqitnWdstgkvtepqtil

LAFRRKVRALNPRDAGPVIVHCSVGVERTGAYIVIDAMLEQAKKSRTVDIRNYLIAIRKHRPHMVQTKEQYSFIHSAVLEALTCGNTEI
| . .....   |  ....|||| .| |.. .. ..  ....|.  ..|. . |   |  .|..||| ||| ||  .||| |....|  
lvieemyktqrkrgntsivvhCsdtvGrsamfcaaattinkckteGviDvfqvlksqriqkpgsvqtveqykfindivleyldsfetys

subfamily_PTPN1_pd Subfamily PTPN1 141-399 2e-64 212.1 In-house 17-281 (290) alignment
Range on Protein: 141-399
Range on HMM: 17-281/290.0
NNGQQFPWGAARKPANknKNKNRYANIVAYDHSRVVLERVNGdedlDYINASFIHgYDGTPRSFIASQGPLPPAFEGFWRMVWEQNSQSIVMLTNLVGLN
.. ..||  .|..|.|  .|.||| ..  |||||..||| .     ||||||...  .   ||.| .||||| . . ||.|||||.|...||| ..|  .
keasdfptreaklpen..rnlnryrdvspydhsrikleradn....dyinaslve.leeakrsyiltqGPlpntvdhfWqmvWeqkskavvmlnkvveke

KTKCHKYWPDKTE----TYG--GVTVTLHQSEVFAGYENCTFILSKEKRSGSRIVRQFHFTVWPDKGVPQYATAVLAFRRKVRAL--NPRDAGPVIVHCS
..||..||| . |    ..    ..|.| . |.   |   .. | . |   .| . .||.| ||| |||.  .| | |  |||      .| ||...|||
qikcaqywPqgeeekellledtklkvkliseerksyytvrllelenlktqetreilhfhyttwpdfgvpespaaflkflfkvresGslssdvGpavihcs

VGVERTGAYIVIDAMLEQAKKSR---TVDIRNYLIAIRKHRPHMVQTKEQYSFIHSAVLEALTC--GNTEIQ
 |. |.|.....|..| . .|.    .|||.. |...||.|  ..||..|  | . |.||   .  |.. .|
aGiGrsGtfclvdtclvliekkddlssvdikkvllelrkyrlGliqtadqlrfsylaileGakvikgdssvq

subfamily_PTPN3_pd Subfamily PTPN3 148-390 1.4e-63 209.5 In-house 33-274 (280) alignment
Range on Protein: 148-390
Range on HMM: 33-274/280.0
WGAARKPANKnkNKNRYANIVAYDHSRVVLERVNGdedlDYINASFIHG-YDG--TPRSFIASQGPLPPAFEGFWRMVWEQNSQSIVMLTNLVGLNKTKC
  |||||.|   .|||| .|..||. || |.  .     |||||...    ..  .   .||.||||. . . ||.|||||.|. |||||.||   ..||
isaarkpenl..sknryrdilpydatrvklkeset....dyinanyvnmeipstglvnryiatqGPlaktatdfWqmvweqksslivmlttlverGrvkC

HKYWPDKTE--TYGGVTVTLHQSEVFAGYENCTFILSKEKRSGSRIVRQFHFTVWPDKGVPQYATAVLAFRRKVRALNPRDAGPVIVHCSVGVERTGAYI
|.|||....  .||. .|......    |    ..|.... . .| . |. .. |||.|||. .. .| | ..||.|   .  ||.|||| |..||| .|
hqyWPetedeleygefsvkcekedetksyvlrelvlkdketkeerkilqlqylaWpdhgvPddsadflefvervrklrsgkeePvvvhCsaGigrtGvli

VIDAMLEQAKKSRTVDIRNYLIAIRKHRPHMVQTKEQYSFIHSAVLEA
...  |    ... | . . .  .|  |  .|||..|| |.  |.|..
lletalalieaaepvypldivrtmrdqramlvqtasqykfvCeailkv

subfamily_CG7180_pd Subfamily CG7180 156-395 6.9e-63 207.0 In-house 40-294 (296) alignment
Range on Protein: 156-395
Range on HMM: 40-294/296.0
NKNKNKNRYANIVAYDHSRVVLERVNGDEDLDYINASFIHGYDgTPRSFIASQGPLPPAFEGFWRMVWEQNSQSIVMLTNLVGLNKtKCHKYWPDK-TET
..|..|||. ..| ||. |||||...|.|. |||||... ..   .. .|  ..|   . . |||.|........|.||.    .| ....||| |  | 
kenreknrdvkvvPyDynRvvLekldGeeksdYinavyvdsfl.kkkeyivteapkketvdefWrlvydeeisavvvLtktfdfak.mypsywpnkskeq

YGGVTVTLHQSEVFAGYENCTFILSKE----------KRSGSRIVRQFHFTVWPD-KGVPQYATAVLAFRRKVRALNPRD-----AGPVIVHCSVGVERT
|| . | . ... .|  .  || | |.               |||..|..|.|.  . ||  ..|.. .||.|| .  .       |||.|..| |. |.
ygeifveiveekqyanlkirtfkltkkivalteqekqvkaetRivklfqlteWeledkvPlstnalielrrrvrlwrekvdedpeegPvvvvssdGasRs

GAYIVIDAMLEQAKKSRTVDIRNYLIAIRKHRPHMVQTKEQYSFIHSAVLEALTCGN
|.|. ||| ||...|   ||. ...  .|..||..|...|.| .|   .|||. |. 
GvylaidanlelvekeeevdvFeavktlrrsRpqLvenveeYkyiYdvlleavlcnk

subfamily_PTPN13_pd Subfamily PTPN13 154-392 8.2e-63 207.2 In-house 33-270 (273) alignment
Range on Protein: 154-392
Range on HMM: 33-270/273.0
PANKNKNKNRYANIVAYDHSRVVLERVNGdedldYINASFIHGYDGTP-RSFIASQGPLPPAFEGFWRMVWEQNSQSIVMLTNLVGLNKTKCHKYWPDKT
  ..||.|||| |.. ||..|| |.   |     |||||.|.   |    ..||.||||| . . ||.|||||... |.|.|. .  .| |||.|||...
kkkenkdknryrnvlPydetrvklgdegg.....yinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweqkaeviamvtlekekgkvkchrywPesk

E----TYGGVTVTLHQSEVFAGYENCTFILSKEKRSGSRIVRQFHFTVWPDKGVPQYATAVLAFRRKVRALNPrDAGPVIVHCSVGVERTGAYIVIDAML
.     .. ..|.| . .   |.   .. ... . . || | ...|. ||| |||. |. .| | ..|| |.  ||||..|||| |. |.|..|.||..|
nkklkvsnrlevellkvqkldgfvvralavkdsesgesrevahlnfvkwPdhgvPssaaellqfvaevrrlqt.dagPivvhcsaGiGrsGtlitidvvl

EQAKKSRTVDIRNYLIAIRKHRPHMVQTKEQYSFIHSAVLEALT
.  .. . .|... .  .|. |  .||||.|| |.. |.||.|.
glierdkefdvkeivrklreqrqgvvqtkdqyifvykailevlk

subfamily_PTPRN_pd Subfamily PTPRN 132-390 9e-62 203.4 In-house 30-291 (297) alignment
Range on Protein: 132-390
Range on HMM: 30-291/297.0
RLETEYKKFNNGQQFPWGAARKPANKNKNKNRYANIVAYDHSRVVLERVNGDEDLDYINASFIHGYDGTPRSFIASQGPLPPAFEGFWRMVWEQNSQSIV
||| |.. . . .. |  ..   |.|| .|||......|||||| |.. . .|. ||||||.|   |    ..||.||||.     ||.||||| .  ||
rlekewealcayeaepstkevakaeknvkknrskavlpydhsrvklkeeasaeksdyinasaildhdprapayiatqgplastvadfwqmvweqGvvviv

MLTNLVGLNKTKCHKYWPDK-TETYGGVTVTLHQSEVFA-GYENCTFILSKEKRSGSRIVRQFHFTVWPDKGVPQYATAVLAFRRKVRALNPRDAGPVIV
.||.|   . ..|..||||. .|.|.   | |    ...  |   .| |   . | .| | ||||  ||..|||  | ..| |||||       . |..|
nltrleeegvkqckrywpdeGsevyhiyevhlvsehiwcddylvrsfylknlqtsetrtvtqfhflswpeegvPasaksllefrrkvnksyrGrscpivv

HCSVGVERTGAYIVIDAMLEQAKK-SRTVDIRNYLIAIRKHRPHMVQTKEQYSFIHSAVLEA
||| |. |||.||.|| .|.. .|  . .||   |  .|  ||..|.||.|. |. .|| | 
hcsdGaGrtGvyilidlvlnrllkGvkeidiaatlehlrdqrpglvktkdqfefaltavaee

subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 156-389 1.2e-61 203.1 In-house 18-262 (270) alignment
Range on Protein: 156-389
Range on HMM: 18-262/270.0
NKNKNKNRYANIVAYDHSRVVLERVNGDEDLDYINASFIHGYDGTPRSFIASQGPLPPAFEGFWRMVWEQNSQSIVMLTNLVGLNKTKCHKYWPDKTET-
 ..|. ||||.|.   ..||.||... |.   |||| ...|.|| ....||..|||| . . ||||.||.....|||.|.|.  ...|| .||| .... 
argkklnRyadiLPsPatRvrleeleedsataYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkgrkkCerYWpaepkek

----YGGVTVTLHQSEVFAGYENCTFILSkEKRSGSRIVrQFHFTVWPDKGVPQYAT------AVLAFRRKVRALNPRD--AGPVIVHCSVGVERTGAYI
    .| ..|.  ..|   ||      |  || .  |.|  |... |||.|||. .        .|.  |.||. . .   |.|..|||| ||.|||  |
vkledgkikvlalseekeegyiltrlrle.ekgeerrlv.HfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkaePllvHcsaGvgRtGtli

VIDAMLEQAKKSRTVDIRNYLIAIRKHRPHMVQTKEQYSFIHSAVLE
..| ...  .... ||. . . ..||.|. .||. ||| |.. ||.|
alDiavrlLeetkkvdvlaiieelRkdRmalvqhpeqyeflykavve

subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 157-405 2.7e-60 199.1 In-house 47-293 (439) alignment
Range on Protein: 157-405
Range on HMM: 47-293/439.0
KNKNKNRYANIVAYDHSRVVLERVNGDEDLDYINASFIHGYDgTPRSFIASQGPLPPAFEGFWRMVWEQNSQSIVMLTNLVGLNKtkchkYWPDKTETY-
 .. |||| ...|.||.||.|. . |     |||| .|.||  ... .||.|||   . . |||.|.|...  ||||||||   |     ||| ..|.. 
ydqtknrykdvgafdhtrvtlqeipgvphshyinanyikGyy.ddklyiatqgpkkettddfwrlviekktvtivmltnlvesyk.....ywpsdaevcy

GGVTVTLHQSEVFAGYENCTFILSKEKR--SGSRIVRQFHFTVWPDKGVPQYATAVLAFRRKVRALNP-RDAGPVIVHCSVGVERTGAYIVIDAMLEQAK
| ..|   .   .  |    | . .|.      | | |||.. |||| ||  |. || | | . . |  .. |||.|||| || |||. | .|  ||| |
gdiavrvdrnielpnyvirgfkvfnerdttekertvlqfhyiawpdknvpaqashvldflrainsandkeeygpvvvhcsagvGrtGtiialdialeqlk

KSRTVDIRNYLIAIRKHRPHMVQTKEQYSFIHSAVLEALTCGNTEIQSEKYNQ
    |||.  .  .||.| .|||.  || ||. |||| .  |.. .. .....
lenkvdikgivkvlrkqrkqmvqalcqyvfiynavledivyGdiavtidefkk

subfamily_PTPN23_pd Subfamily PTPN23 132-390 6.4e-57 187.6 In-house 16-279 (288) alignment
Range on Protein: 132-390
Range on HMM: 16-279/288.0
RLETEYKKFNNGQQFP-WGAARKPANKNKNKNRYANIVAYDHSRVVLErvnGDEDlDYINASFIHGYDGTPRSFIASQGPLPPAFEGFWRMVWEQNSQSI
 |....|.... |.    . .   |... .|||. .|. |||.||.|.   | .| |||||||...   .  .|||.|.||...   ||.||.|| |. |
aldkkfkeleqkqdkearkrsiaiaklyseknrsrdilPyDhnRvklr...gskD.DYinAsfvkdlspgcPdfiatqaPlqstlnDFWlmvyeqkssvi

VMLTNLVGLNKTKCHKYWP---DKTETYGGVTVTLHQSEVFAGYENCTFILSKEKRSGSRIVRQFHFTVWPDKGVPQYATAVLAFRRKVRA----LNPRD
|||..   |.|.|...|||   ..|...| ..|||.. .    . . ...|. .. .  . |.  ..| ||. |||.    .|.|  .|..     . . 
VmllskeelgkpkvdrYwPedkgetvkfgdlsvtlksvretethvervlkletldadavksvshlqltsWpelGvPasPetllqfldevesayeavqrks

AGPVIVHCSVGVERTGAYIVID-AMLEQAKKSRTVDIRNYLIAIRKHRPHMVQTKEQYSFIHSAVLEA
  |..|||| ||.|||.. ..  |. |  |.   .|| . .  .|. | .|||.|||. |  .|||||
ktPlvvhCsaGvgRtgvfalvyaavrelekgnglldiiqvvsrlreqRrfmvqekeqlkfsyeavlea

0051299 (Phosphotyrosine protein) phosphatases II 394-623 4.2e-54 179.3 In-house 1-227 (288) alignment
Range on Protein: 394-623
Range on HMM: 1-227/288.0
GNTEIQSEKYNQAMQKLAsvngKFPMTGYALEFQRLNSVTSReipvEEKSVGEKPQNLHKNRFSDIIALNSCRVMLHKEHADEESDYINAVFLHAHRGRN
|.|||. |.. ....||     .  .||.. ||..| |..       . |.. .|.||.|||.|||......|| |. .. .|.|||||| ... ..  .
gdteisveellklvlkll....angltglleefeellsllpd....ltlsaallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyidgynlkr

AFIATQHPLLETVEDFWRMVTDYDIGTIVMLNNLHDQVAPESSEYWPDHGATKYGHIGISVLSKQKKGDVICVKPKVT------RKKKTHEVRHLHHVSW
.|||||.|| .||||||||| .... .||||..|..     .  |||..| ..||.| .  || ....|... . .||       ......|.|.|. .|
kfIatqgPlpntvedFWrmvweqnvrvIvmltklvelgrekcaqYwplggsltygditvtllseevlddytvrtlevtnldlldgdgesrtvthfhytnw

TDKCIPKVSRSVLDLLDEVQTSQQqCGNVPVLVQCR
 | ..|   ...||.| .|.....  |. ||.| |.
pdhgvpdspellldflrlvrkala.sgggpvvVHCs

subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 133-397 5.4e-54 177.9 In-house 17-299 (301) alignment
Range on Protein: 133-397
Range on HMM: 17-299/301.0
LETEYKKFNNGQQFPWGAARkpANKNKNKNRYANIVAYDHSRVVLERVNG--DEDLDYINASFIHGYDGTpRSFIASQGPLPPAFEGFWRMVWEQNSQSI
.| .||. ..|.. .        ..||. ||. ||. ||. |..|.  .       .|||||.|.||  . . |||.|||.      |||..|..  .||
feeqykelkegedksctvgl..seenkalnrfknitvyddnriilkpkpnldlcqreyinasyidgysek.kkfiaaqgpmkktlvdfWrliwqekpvsi

VMLTNLVGLNKTKCHKYWPD---KTETYGGVTVTLHQSEVFAG-----------------YENCTFILSKEKrsGSRIVRQFHFTVWPDKGV-PQYATAV
||.|||    |.||..|||.   ..|..| .||||... |.                   | . .|  ...|   |. | |.. | ||. || ....| .
vmvtnlkegtkskceqywpnseaeseefgpftvtlvneqvyPdfvirqlnvkiqdgsnngyierkfkvksdk..sswdvlqlqvtdWpqdGvvreprtvL

LAFRRKVRALNPRDAGPVIVHCSVGVERTGAYIVIDAMLEQAKKSRTVDIRNYLIAIRKHRPHMVQTKEQYSFIHSAVLEALTCGNTE
 .    . . .  . |||.|||| .| |.| |. ..  |||.|    ||. .   |.|. .| .|.| |||..|. .. . |.. .|.
qviddvihrqqkigggpvvVHCSdtVsrsGvYcsvsiglEQckaegVVdvfqvtkavrrskpgaVtTLeqytsiydvidmylqlnsty

0050432 (Phosphotyrosine protein) phosphatases II 391-623 2.7e-53 176.7 In-house 12-240 (308) alignment
Range on Protein: 391-623
Range on HMM: 12-240/308.0
LTCGNTEIQSEKYNQAMQKLAS-VNGKFPMTGYALEFQRLNSVTSreipVEEKSVGEKPQNLHKNRFSDIIALNSCRVMLhkehaDEESDYINAVFLHAH
|....|.|. ..... ...|.  ..... ....  ||..|.||.     ..| ||...|.| .|||..||... ..|| |     ||.|||||| . . .
llfrdtsilvsslklsvldllkllekaldlglleeefeellsvkp....lleysvallpenkdkNrykdilpydhsRVkl.....degsdYInAsyvdgy

--RGRNAFIATQHPLLETVEDFWRMVTDYDIGTIVMLNNLHDQVAPESSEYWPDH---GATKYGHIGISVLSKQKKGDVICVKPKVTR--KKKTHEVRHL
  . ...|||||.|| .||||||||| .... .||||..|..   .   .|||.    | ..||.. . .|| ....|... . ..|   ......|.|.
ssklprkfIatqgPlpntvedFwrmvweqnvrvIvmLtklvengrekcaqYwplelgggsleygkftvtllseevlddytvrtleltnlgdgesrtvthf

HHVSWTDKCIPKVSRSVLDLLDEVQTSQqqcGNVPVLVQCR
|. .| | ..|   ...||.|..|..|.   .. |..| |.
hytnWpdhgvPpspeilldflelvrksl...pggpivVHCs

subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 151-399 1.3e-51 170.2 In-house 26-274 (283) alignment
Range on Protein: 151-399
Range on HMM: 26-274/283.0
ARKPANKNKNKNRYANIVAYDHSRVVLERVNGdedlDYINASFIH--GYDGTPRSFIASQGPLPPAFEGFWRMVWEQNSQSIVMLTNLVGLNKTKCHKYW
  . |..||.|||. .||..|  || |.  .     |||||.||     .   . .|..|.||  .   ||.||....  .|||||.|   .. || .||
diasadenkrknrnqeivpadqwrvelksesr....dyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfdekitaivmltklqedlrikCsqyW

PDK-TETYGGVTVTLHQSEVFAGYENCTFILSKEKRSG-SRIVRQFHFTVWPDKGVPQYATAVLAFRRKVRALNPRDAGPVIVHCSVGVERTGAYIVIDA
| . .| ||  ||||..      .    ..| ..  .  . ..  . .  | . |      ... | . .   .    ||..|||| |. ||...| . |
PkrGsedyGeftvtlrkettsnsfiikelllrvnssakstlllahyqvidWleygeqaiinslvkfnkvislqteskkgPivvhCstgiGrtavfiaasa

MLEQAKKSRTVDIRNYLIAIRKHRPHMVQTKEQYSFIHSAVLEALTCGNTEIQ
 ...|. .  ||. . .  .|..|. .|||..|| ..| .|||   ||.|.| 
svkdaltesvvdvfavvkimreqrmmavqtldqyklvhelvleqalcgdtqia

subfamily_PTPN14_pd Subfamily PTPN14 155-391 3.5e-50 165.7 In-house 46-296 (300) alignment
Range on Protein: 155-391
Range on HMM: 46-296/300.0
ANKNKNKNRYANIVAYDHSRVVLERVNgDEDLDYINASFIHGY-DGTPRSFIASQGPLPPAFEGFWRMVWEQNSQSIVMLTNLVGLNKTKCHKYWPDK--
 ..|..|||. ... |...|| |   . ... .||||| |.    |. ||.|..||||. . . ||.|||||. | |||||.     |.|..||.|..  
lpenaeknrfkdvlPyednrvelsptk.enstgyinassikvsvggkersyivaqgPleltvqdfWqmvWeqgvqlivmlteeeedgkeksfkyfPkles

---TETYGGVTVTLHQSEVFAGYENCTFILSKEKRSGSRIVRQFHFTVWPDKGVPQYATAVLAFRRKVRALNPR---------DAGPVIVHCSVGVERTG
   | ..|   || . ||    .   .. |     .  | |  . .| |||.|||.  .  | . ..|...  .            ||.|||| || |||
kkktvefgkfkvttkfsedsdsvittglklkhlpskeertvwhlqytDWpdhgvPeDvkgflsyLeevqsvrrktnseveskeskPPvlvhCsaGvGrtG

AYIVIDAMLEQAKKSRTVDIRNYLIAIRKHRPHMVQTKEQYSFIHSAVLEAL
  |. | ...  .. ...||.. |  .|. | ..|||  || |....... |
vlilsdlliatlehneeidikkvlarLreqrmllvqtlaqYkfvYkvlikyl

subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 150-388 1.1e-49 163.7 In-house 32-274 (287) alignment
Range on Protein: 150-388
Range on HMM: 32-274/287.0
AARKPANknKNKNRYANIVAYDHSRVVLErVNGDEDLDYINASFIHGYDGTpRSFIASQGPLPPAFEGFWRMVWEQNSQSIVMLTNLVGLNKTKCHKYWP
|| . |.   .|||||... .|..||.|   .|.   ||||| .. .|     .|||.|||.. .   |||.|.|..| |....|  |   . ||.||||
aaeelaa..vkknryadvlPiddtrvlls.aegelGsdyinanyvasytdd.eafiaaqgPiaatvrdfwravletrsasvitmtreveearlkcykywP

DKTE--TYGGVTVTL-HQSEVFAGYENCTFILSKEKRSGSRIVRQFHFTVWPDKGVPQYATAVLAFRRKV-----RALNPRDAGPVIVHCSVGVERTGAY
..      || .|.|  ..     |   .. | . .   .|.|.|...  ||||...  | ... |  .|      | .  ..||..||..||. |.| .
erevPmrvGGysvvlldydikePeygvralrlidletrearvvkqldllswPdkvlaPtavglirfvldvkqhielardasevGPlvvhddvGiGrsGil

IVIDAMLEQAKKSRTVDIRNYLIAIRKHRPHMVQTKEQYSFIHSAVL
. . ..... ..   ||. . .| .|..|  .||.  |. ..  |. 
latlvlvsrledlGrvdvaavvirlreyraalvqavvqlrllyealv

0046845 (Phosphotyrosine protein) phosphatases II 424-623 2.8e-49 163.4 In-house 4-212 (284) alignment
Range on Protein: 424-623
Range on HMM: 4-212/284.0
LEFQRLNSVTSREIpvEEKSVGEKPQNLHKNRFSDIIALNSCRVMLHKEHAD-EESDYINAVFLHAH-----RGRNAFIATQHPLLETVEDFWRMVTDYD
 ||..|.|.|   .   . ||. .|.||.|||..||......|| |. .. | |.|||||| ... .     . ...|||||.|| .||||||||| ...
eefeellsltvkll..lslsvallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweqn

IGTIVMLNNLHDQVAPESSEYWPDHG-ATKYGHIGISVLSKQKKGDVICVKPKVTR---KKKTHEVRHLHHVSWTDKCIPKVSRSVLDLLDEVQTSQQQ-
. .||||..|..      . |||. |   .||.. . .||...|.|... . ..|.   ......|.|.|. || | ..|  ....|..|..|...... 
vrvIVmltelvengrekcaqYwplegevltygdftvtllseevkddytvrtleltnlgytgesrtvthfhytswpdhgvppspedlleflrlvrellenl

CGNVPVLVQCR
 |. |..| |.
pgggpivVHCs

subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 423-622 4.3e-49 162.3 In-house 23-220 (318) alignment
Range on Protein: 423-622
Range on HMM: 23-220/318.0
ALEFQRLNSVtsREIPVEEKSvgEKPQNLHKNRFSDIIALNSCRVMLHKEHADEESDYINAVFLHAHRGRNAFIATQHPLLETVEDFWRMVTDYDIGTIV
  |..||. .  .| . . ||   .| | .|||. .|.| ...|| |.. . .|.|||||| ..  .| ..|.||.| || ||.||||||| . .  .||
seeyerlsrs..eetvtslks..lepvnkaknryanilaydhtrvkLqmlegeegsDyinanyidGyrrkkayiaaqaPlpetieDfWrmvWeqnsaviv

MLNNLHDQVAPESSEYWPDHGATKYGHIGISVLSKQKKGDVICVKPKVTRKKK--THEVRHLHHVSWTDKCIPKVSRSVLDLLDEVQTSQQQCGNVPVLV
|| .....       |||..|...||.. . . .. . .| .  . ||||...  . .||  |. ||.|. .|. . |.|||. .|.. ||..|. |..|
mltqeeergkakvhryWPskgsrsygklvvelkeevelsdyvlrefkvtrteeeesrqvrqyhytsWpdegvpesgaslldlvrqvskaqqksgagpivv

QC
 |
hC

0041856 (Phosphotyrosine protein) phosphatases II 158-397 5.2e-49 161.6 In-house 1-177 (182) alignment
Range on Protein: 158-397
Range on HMM: 1-177/182.0
NKNKNRYANIVAYDHSRvvlervngdeDLDYINASFIHGYDGTPRsFIASQGPLPPAFEGFWRMVWEQNSQSIVMLTnlvglnktkCHKYWPDKTetygg
|..|||| .|. |||||          |||||||... |.  . | ||| ||||.  .. |.||..|.. ..||.||         .. |||..      
nldknrysdilpydhsr..........dldyInanlylgslpatr.fiatqgpllstvadflrmlkelgittivnlt.........eelywpell.....

vtvtlhqsevfagyenctfilskekrsgSRIVRQFHFTVWPDKGVPQyATAVLAFRRKVRAlnprDAGPVIVHCSVGVERTGAYIVIDAMLEQakksrTV
                             | . |.... ||| |||     .|.| ..|..    . |||.|||| || |||...... |...      |
............................erlgiqylylpwpDhgvpd.ldelldfieevle....eggpvlVHCsaGvgRtgtlvaaylmkkl.....gv

DIRNYLIAIRKHRPHMVQTKEQYSFIHSAVLEALTCGNTE
.... .  .|..||.||.| .|| |.. |.|| | ...|.
sleeavklvrsrRpgmvitpnqyfflqlallellllkktr

0047943 (Phosphotyrosine protein) phosphatases II 413-623 1.4e-48 161.1 In-house 5-213 (273) alignment
Range on Protein: 413-623
Range on HMM: 5-213/273.0
VNGKFPMTGYALEFQRLNSVTSreipVEEKSVGEKPQNLHKNRFSDIIALNSCRVMLhkehADEESDYINAVFLHAHRGRNAFIATQHPLLETVEDFWRM
..... .|....||..| |..     . ..||...|.|..|||..||......|| |     |..|||||| ..  ..  ..|||||.|| .||||||||
lekllgltllleefelllslkp....lltysvallpenkdknrykdilpydhsrvkl....gdggsdyinAsyvdgynlkrkfiatqgPlpntvedfwrm

VTDYDIGTIVMLNNLHDQVAPESSEYWPDHG---ATKYGHIGISVLSKQKKGDVICVKPKVTR--KKKTHEVRHLHHVSWTDKCIPKVSRSVLDLLDEVQ
| .... .||||..|..   .    |||. |    ..||.. . .|| ..|.|..  . ..|.   .....|.|.|. .| | ..|    |.|.....|.
vweqnvrviVmLtelvelgrekcaqYwpleggelsltygkftvtllseetkddytvrtleltnlgtgesrtvthfhytgwpdhgvppslesllefielvr

TSQQQC-GNVPVLVQCR
. .... .| ||.| |.
kalealpsngpvvVHCs

0040438 (Phosphotyrosine protein) phosphatases II 420-623 2.4e-48 160.4 In-house 18-217 (317) alignment
Range on Protein: 420-623
Range on HMM: 18-217/317.0
TGYALEFQRLNSVtsreiPVEEKSVGEKPQNLHKNRFSDIIALNSCRVMLHKEHADEESDYINAVFLHAHRGRNAFIATQHPLLETVEDFWRMVTDYDIG
|.   ||..| |.     .... ||.|.|.| .|||..||. . ..|| |. .  |..|||||| . . .. ...|||||.|| .||||||||| .....
talleefedllsl.....kldtysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyvdgpnlkrkfIatqgPlpntvedFwrmvweqgvt

TIVMLNNLHDQVAPESSEYWPDHGATKYGHIGISVLSKQKKGDVICVKPKVT--RKKKTHEVRHLHHVSWTDKCIPKVSRSVLDLLDEVQTSQQqCGNVP
.||||..| .   . . .|||. . ..||.. . .|| .......  . .|.  .......|.|.|. .|.| ..|.  ...||.|..|.....  .. |
vivmLteleelgrekcaqYwplgetltygdftvtllseeelagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfleavreale.dpggp

VLVQCR
||| | 
vlVHCs

0051429 (Phosphotyrosine protein) phosphatases II 187-411 2.6e-48 160.3 In-house 5-244 (272) alignment
Range on Protein: 187-411
Range on HMM: 5-244/272.0
DYINASFIHGYdGT---PRSFIASQGPLPPAFEGFWRMvWEQNSQSIVMLTNLVGLNKTKCHKYWP-------------DKTETYGGVTVTLHQSEVFAG
.||||... || |    |. ...|.||||   ..|||. .|..  .||.|.... ... ||..|||             . | .|| ..|||.. |..  
gyiNardvggy.grvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseellld

YENCTFILSKE-KRSGSRIVRQFHFTVWPDKGVPQYAtaVLAFRRKVRAlnprdAGPVIVHCSVGVERTGAYIVIDAMLEQAKKSRTVD--------IRN
|   ...|... . . .| |...|.| ||| |||| |  .|.. . ...      |||.|||| |. ||| ..... .|..  ..  ||        ...
yilrellltlllsagearevmhlhytdwpdhgvpqea..llellellld.....ggpvlvHCsaGkdRTGtvvallllllgvsletivddYlltnlylee

YLIAIRKHRPHMVQTKEQYSFIHSAVLEAlTCGNTEIQSEKYNQAMQKLA
..  .|..||..||| ||| |.. |.||.  .. .... | ...|.. . 
aveelraqrpgavqteeqylflyeallel.lrsllsvraeyllaaldaid

subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 420-622 1e-47 157.6 In-house 21-219 (288) alignment
Range on Protein: 420-622
Range on HMM: 21-219/288.0
TGYALEFQRLNSVTSReipvEEKSVGEKPQNLHKNRFSDIIALNSCRVMLHKEHADEESDYINAVFLHAHRGRNAFIATQHPLLETVEDFWRMVTDYDIG
||.  |.. | .. .     .....|....| .|||. .|....  || |.| .  ...||||| ... .......|||| || .||.|||..| .... 
tgfseeynsLaalekt....ksvtagrlavnakknRyrnilpyDekrvklkkleeeagaDYinasyidgekkkkkyiatqgPladtvndfWelvyenkts

TIVMLNNLHDQVAPESSEYWPDHGA-TKYGHIGISVLSKQKKGDVICVKPKVTRKKKTHEVRHLHHVSWTDKCIPKVSRSVLDLLDEVQTSQQQCgNVPV
|||||..| ..   .  ||||| .  ..||.. . ........|..  |  . .||.  |. .... .|.|. .|. .. .|.||. |....|.    |.
tivmltelveggktkCeeYWPdadkpknyGsvtvtlveskeledfvlrklllekkkteleitqyqylaWpdhgvPeskapllellrqvkvanqad.tgpi

LVQC
.|.|
ivhC

0036941 (Phosphotyrosine protein) phosphatases II 413-623 1.1e-47 158.2 In-house 6-215 (297) alignment
Range on Protein: 413-623
Range on HMM: 6-215/297.0
VNGKFPMTGYALEFQRLnsvtSREIPVEEKSVGEKPQNLHKNRFSDIIALNSCRVMLhkehADEESDYINAVFLHAHRGRNAFIATQHPLLETVEDFWRM
..... ....  ||..|     . ..  ..||...|.||.|||..||......|| |     ||.|||||| ..  ..  ..|||||.|| .||||||||
lekllflalllkefeel....lpllllgslsvallpenleknRykdilpydhtRVkl....ddegsdYinAsyvdgydlkrkfIatqgPlpntvedFWrm

VTDYDIGTIVMLNNLHDQVAPESSEYWPDH--GATKYGHIGISVLSKQK--KGDVICVKPKVTR--KKKTHEVRHLHHVSWTDKCIPKVSRSVLDLLDEV
| .... .||||..| .   .   .|||.   .  .||.. . .|| ..  ..|..  . .||   ......|.|.|. .| | ..|   .|.||....|
vweqnvtvIvmltelvelgrekcaqywpleegesltygdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfielv

QTSQQQC-GNVPVLVQCR
.. ...  .. |||| |.
rkvlkllpsggpvlVHCs

DSPc_SM00195 425-623 3e-47 156.5 In-house 5-203 (263) alignment
Range on Protein: 425-623
Range on HMM: 5-203/263.0
EFQRLNSVTSREipveEKSVGEKPQNLHKNRFSDIIALNSCRVMLHKEHADEESDYINAVFLHAHRGRNAFIATQHPLLETVEDFWRMVTDYDIGTIVML
||..|.. || .    |.. .||..| .|||...|.  .. || |.||. .|.|||||| ..  .. ....||||.|| .|||||||||.. .. .||||
efekleestspk....etteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivml

NNLHDQVAPESSEYWPDH--GATKYGHIGISVLSKQKKG-DVICVKPKVTRKK--KTHEVRHLHHVSWTDKCIPKVSRSVLDLLDEVQTSQQQCgNVPVL
..  ..   . ..|||.   | ...|.| . . ...||  ..|  . ..| ..  .|..|..... .|.|. .|.  .|||.|| .|..|...  ..|..
teeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkksksts.sgpiv

VQCR
|.| 
VhCs

PTPc_SM00194 425-623 3e-47 156.5 In-house 5-203 (263) alignment
Range on Protein: 425-623
Range on HMM: 5-203/263.0
EFQRLNSVTSREipveEKSVGEKPQNLHKNRFSDIIALNSCRVMLHKEHADEESDYINAVFLHAHRGRNAFIATQHPLLETVEDFWRMVTDYDIGTIVML
||..|.. || .    |.. .||..| .|||...|.  .. || |.||. .|.|||||| ..  .. ....||||.|| .|||||||||.. .. .||||
efekleestspk....etteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivml

NNLHDQVAPESSEYWPDH--GATKYGHIGISVLSKQKKG-DVICVKPKVTRKK--KTHEVRHLHHVSWTDKCIPKVSRSVLDLLDEVQTSQQQCgNVPVL
..  ..   . ..|||.   | ...|.| . . ...||  ..|  . ..| ..  .|..|..... .|.|. .|.  .|||.|| .|..|...  ..|..
teeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkksksts.sgpiv

VQCR
|.| 
VhCs

subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 421-622 5.3e-47 155.4 In-house 24-223 (319) alignment
Range on Protein: 421-622
Range on HMM: 24-223/319.0
GYALEFQRLNSVTSReipveEKSVGEKPQNLHKNRFSDIIALNSCRVMLHKEHADEESDYINAVFLHAHRGRNAFIATQHPLLETVEDFWRMVTDYDIGT
. . ||. |.  ..      . .  .|..| .|||...|.| . .||.| . .  |.|||||| |. ... |..||||| || .|.||||||| .... .
llekefkllkeavnd.....tfdsaskeenkkknryqnilaydrtrvvlseldgvegsdyinasfidgyqerekfiatqaPlentiedfWrmvWeeessi

IVMLNNLHDQVAPESSEYWPDHGATKYGHIGISVLSKQKKGDVICVKPKVTRKKKT---HEVRHLHHVSWTDKCIPKVSRSVLDLLDEVQTSQQQCGNVP
.|||..| ...  . ..|||..  ..||.. . ....... |.|  | |. .|.      || | .. .|.|. .|. ..|.|||| ... |...  . |
vvmltklveklkvklkkywpeenfeeyGrlivtleeeeeledyiirklklnkkssevetRevkhfqyteWpdhdvPekatslldllkrirksrektqsgP

VLVQC
. | |
ivvhC

0039614 (Phosphotyrosine protein) phosphatases II 412-623 1.4e-46 154.7 In-house 24-230 (297) alignment
Range on Protein: 412-623
Range on HMM: 24-230/297.0
SVNGKFPMTGYALEFQRLNSVTSreipvEeKSVGEKPQNLHKNRFSDIIALNSCRVMLHKEHA-DEESDYINAVFLHAHRG-RNAFIATQHPLLETVEDF
 .. .. .|.. |||..| |..      . .|....|.| .|||..||......|| |. |   |..|||||| ..  ..   ..|||||.|| ||||||
llekansktllllefeellslkp.....d.ysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfIatqgPlpetvedF

WRMVTDYDIGTIVMLNNLHDQVApESSEYWPDHGAtKYGHIGISVLSKQKKGDVICVKPKVTRKKKTHEVRHLHHVSWTDKCIPKVSRSVLDLLDEVQTS
|||| .... .||||..| .       .|||. |  .||.. . .|. .......  . .||.......|.|.....| | ..|  ....|..|..|.. 
wrmvweqgvtvivmLtklvelgr.kcaqywpeegg.tygdftvtllkvehldgytvrtlevtnngesrtvthfqytgwpdhgvppslellleflelvrea

QQQC-GNVPVLVQCR
.... .. |||| | 
laelpkggpvlVHCs

0045450 (Phosphotyrosine protein) phosphatases II 419-623 3.8e-46 153.6 In-house 26-242 (307) alignment
Range on Protein: 419-623
Range on HMM: 26-242/307.0
MTGYALEFQRLNSVTSREipVEEKSVGEKPQNLHKNRFSDIIALNSCRVMLHKEHAD-EESDYINAVFL--------HAHRGRNAFIATQHPLLETVEDF
.||.. ||..|.||| .   . | |....|.| .|||..||......|| |. .. . |.|||||| .         . ..  ..|||||.|| ||||||
ltgllkefekllsvtvfl..lgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydlkrkfIatqgPlpetvedF

WRMVTDYDIGTIVMLNNLHDQVAPESSEYWPDHGAT-KYGHIGISVLSKQKKGDVICVKPKVT---RKKKTHEVRHLHHVSWTDKCIPKVSRSVLDLLDE
|||. ......||||..| .   .   .|||| | .  ||.. . .||......... . .||    ......|.|.|. .| | ..|.   ..||...|
wrmlweqgvtvivmltelvelgrekcaqywPdegeeltygnftvtllseehldgytvrtlevtdldgtgesrtvthfhytgwpdhgvppsfeelldfiee

VQTSQQQC-GNVPVLVQCR
|.. .... .. |||| |.
vrkaleelpkggpvlVHCs

subfamily_PTPRK_pd Subfamily PTPRK 443-623 2.3e-45 149.8 In-house 36-218 (314) alignment
Range on Protein: 443-623
Range on HMM: 36-218/314.0
SVGEKPQNLHKNRFSDIIALNSCRVMLHKEHADEESDYINAVFLHAHRGRNAFIATQHPLLETVEDFWRMVTDYDIGTIVMLNNLHDQVAPESSEYWPDH
 .  | .| .|||. ||.| . .||.|.  . | .|||||| .. ...  .|||.||.|| |||.||||.| |..  .||||..| .. . . ..|||..
daakkdenreknrsgdilaydrsrvflitidgdpssdyinaalidsykrpaafivtqgPlqetvkdfWrlvydencasivmltelvevgrvkClkyWPed

GATkYGHIGISVLSKQKKGDVICVKPKVTR----KKKTHEVRHLHHVSWTDKCIPKVSRSVLDLLDEVQTSQQQcGNVPVLVQCR
. . ||.| . ... . . ...    .|..    .....|||......|.|  .|.  ...|.|. .|..||.. .. ...| | 
tev.ygdikvelvetellaelvvrifrveklargqeeirevrqfqflgWpdhdvPvsatgllklvrrvkksqee.eaGrivvhCs

subfamily_Ptp69D_pd Subfamily Ptp69D 421-624 4.7e-45 149.0 In-house 23-228 (307) alignment
Range on Protein: 421-624
Range on HMM: 23-228/307.0
GYALEFQRLNSVtsrEIPvEEKSVGEKPQNLHKNRFSDIIALNSCRVMLHKEHADEESDYINAVFLHAHRGRNAFIATQHPLLETVEDFWRMVTDYDIGT
|.| |...|..    ||.  . .|.||  |. |||. ||.| .. ||.|.|   .|.|||||| |..... .. ||| | |. .|..|||||... .. .
glakeyekLear...eid.kstkvsekkenalknRyedikafDktRvkLkkingkedsdYinasfikgykekkkfiaaqdPveatigDfWRmiaeqevtl

IVMLNNLHDQVAPESSEYWPDHGATKYGHIGISVLSKQKKGDVICVKPKVTRKK-------KTHEVRHLHHVSWTDKCIPKVSRSVLDLLDEVQTSQQQC
|||| || ..   . . |||.   ..||.| . . |..|..| |  . .|..||       ....|   |. .| |  .|.|.|..|.|...|.  ... 
ivmlsnlteknrkkcakYWpiedevqygdilvklvseekhsdyiiReldvskkkeesgevedsrkvvqyhytgWkDskvPevargllklieqvrelykln

gNVPVLVQCRY
 . |..| |. 
.rsPivvhCsa

subfamily_PTPRA_pd Subfamily PTPRA 443-622 6.8e-45 148.4 In-house 51-235 (330) alignment
Range on Protein: 443-622
Range on HMM: 51-235/330.0
SVGEKPQNLHKNRFSDIIALNSCRVMLHKEHADEESDYINAVFLHAHRGRNAFIATQHPLLETVEDFWRMVTDYDIGTIVMLNNLHDQVAPESSEYWPDH
 . .| .| .|||. .|.  .  ||.| . .  |||||||| |.. .. .. |||.| |. |||||||||. ...  ||||| .|...       ||||.
elaskeenkeknrvvnilPydfsrvilsvkeGveesdyinasfidGykekdkfiaaqGPkeetvedfwrmiweqksativmltelkerkeekcaqywPde

GATKYGHIGISVLSKQKKGDV----ICVK--PKVTRKKKTHEVRHLHHVSWTDKCIPKVSRSVLDLLDEVQTSQQQCGNvPVLVQC
|.  ||.| ..|  ..   |.    ..|.  |. ||.||.  || .|  || |  .|  .. .|.|| .|.. .|| .. |. | |
GlvtyGnirvevedetvlvdytvrkflvqqlpdatrekksrlvrqfhftswPdvGvPfepiGmlkllkkvkklnqqsag.pivvhc

subfamily_PTPRB_pd Subfamily PTPRB 397-622 8.5e-45 148.0 In-house 6-225 (293) alignment
Range on Protein: 397-622
Range on HMM: 6-225/293.0
EIQSEKYNQAMQKLASVNGkfpmTGYALEFQRLNSVTSREipveEKSVGEKPQNLHKNRFSDIIALNSCRVMLHKEHADEESDYINAVFLHAHRGRNAFI
.|. ||... ..|... .     .... |...|..| . .    .... |...|  |||...|.. .  || |.. . ...|||||| ... .. .. ||
piklekfeehvkkmkadsd....lrfseeyeelkavgkdq....avkaaelavnraknrytnilpydhsrvkLaalkdesgsDYinanyipgynsprefi

ATQHPLLETVEDFWRMVTDYDIGTIVMLNNLHDQVAPESSEYWPDH-GATKYGHIGISVLSKQKKGDVICVKPKVTRKKKTHEVRHLHHVSWTDKCIPKV
||| || |||.|||||| .    .|||| .| ..      ||||..  .. ||.| ......... | .. . |....|....||..|..||.|  .|. 
atqGPlpetvddfWrmvwekkssiivmltqlvekgkvkCeeYWPadeepvlyGdikvtlvaeeeledwvirelkiekekeerkvrqyhftsWpdhgvPek

SRSVLDLLDEVQTSQ-QQCGNVPVLVQC
....||.. .|.... ... . |..| |
tktlldfvrtvreaiektaskrPivvhC

0043336 (Phosphotyrosine protein) phosphatases II 414-623 1.1e-44 148.4 In-house 14-218 (278) alignment
Range on Protein: 414-623
Range on HMM: 14-218/278.0
NGKFPMTGYALEFQRLNSVTSreipvEEKSVGEKPQNLHKNRFSDIIALNSCRVMLHKEHADEESDYINAVFLHAHRGRNAFIATQHPLLETVEDFWRMV
 ..   |.. |||..|.|..      ...|....|.| .|||..||......|| |. .  |. |||||| ..  ..  ..|||||.|| ||||||||||
lllnlktllllefeellsfkl.....dtysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyvdgynvprkfiatqgPlpetvedFwrmv

TDYDIGTIVMLNNLHDQVAPESSEYWPdHGATKYGHIGISVLSKQKKGDVICVKPKVT--RKKKTHEVRHLHHVSWTDKCIPKVSRSVLDLLDEVQTSQQ
 .... |||||..| .   . . .|||  | ..||.. . .|. ....|..  . .||  .......|.|.|...| | ..|    ..||.| .|.. ..
welgvttivmLtelvelgrvkcaqYwp.ggsltygdftvtllkeehlddytvrtlevtnlgdgesrtvthyhylgwpdhgvpeslsllldflkavreale

qCGNVPVLVQCR
   | |||| |.
.dsngpvlVHCs

subfamily_PTPN12_pd Subfamily PTPN12 421-622 5.3e-44 145.2 In-house 9-214 (290) alignment
Range on Protein: 421-622
Range on HMM: 9-214/290.0
GYALEFQRLNSVTSREI--PVEEKSVGEKPQNLHKNRFSDIIALNSCRVMLHKEHADEESDYINAVFLHAHRGRNAFIATQHPLLETVEDFWRMVTDYDI
 .| |||.| .....     | ....|||..| .|||. ||.  .  ||.|.|.. .|.|||||| |..   |. ..||.| || .|..|||||. ....
efakefqklkklsekykaekvysteagekeenvkknrykDilPydksrvelskieeeegsdYinanfikgvegkleyiaaqgPLpktlddfWrmiweknv

GTIVMLNNLHDQVAPESSEYWPDHGAT--KYGHIGISVLSKQKKG-DVICVKPKVTRKKKTHEVRHLHHVSWTDKCIPKVSRSVLDLLDEVQTSQQqCGN
  .||. .. .        |||..| .  ..|.. ... ....   | .    ||...|....|. .|. .| |. .|.   |.|.|...|.. |.   .
eivvmaCrevelgkkkCerYWpeegeeelefgefevtleeekavdddflirtLkveaqkesrkvyqfhYtaWPDhgvPssaksllelielvrelqe.sed

VPVLVQC
.|..| |
aPlvvhC

Y_phosphatase Protein-tyrosine phosphatase 450-623 1.3e-43 144.5 Pfam-A 1-178 (235) alignment
Range on Protein: 450-623
Range on HMM: 1-178/235.0
NLHKNRFSDIIALNSCRVMLhkEHADEESDYINAVFLHAHRGRNAFIATQHPLLETVEDFWRMVTDYDIGTIVMLNNLHDQVAPESSEYWP--DHGATKY
|..|||..||.. .. || |  .. ...|||||| ... ..  ..|||||.|| .|.|||||||..... .||||..| ..   . ..|||  ... ..|
nkkknRykdilpydktrvkl..kgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeeslty

GHIGISVL-SKQ-KKGDVICVKPKVTRKKKT---HEVRHLHHVSWTDKCIPKVSRSVLDLLDEVQTSQqQCGNVPVLVQCR
|.| . .  ... .. ...  | ... ||.    .||..||. .|.|...|. ..|.|||...|..|. .  . ||.|.| 
gdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkveksk.eaksgpvvVhCs

Y_phosphatase Protein-tyrosine phosphatase 450-623 1.3e-43 144.5 In-house 1-178 (235) alignment
Range on Protein: 450-623
Range on HMM: 1-178/235.0
NLHKNRFSDIIALNSCRVMLhkEHADEESDYINAVFLHAHRGRNAFIATQHPLLETVEDFWRMVTDYDIGTIVMLNNLHDQVAPESSEYWP--DHGATKY
|..|||..||.. .. || |  .. ...|||||| ... ..  ..|||||.|| .|.|||||||..... .||||..| ..   . ..|||  ... ..|
nkkknRykdilpydktrvkl..kgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeeslty

GHIGISVL-SKQ-KKGDVICVKPKVTRKKKT---HEVRHLHHVSWTDKCIPKVSRSVLDLLDEVQTSQqQCGNVPVLVQCR
|.| . .  ... .. ...  | ... ||.    .||..||. .|.|...|. ..|.|||...|..|. .  . ||.|.| 
gdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkveksk.eaksgpvvVhCs

0036282 (Phosphotyrosine protein) phosphatases II 187-384 2.1e-43 143.3 In-house 3-163 (174) alignment
Range on Protein: 187-384
Range on HMM: 3-163/174.0
DYINASFIHGYDGTPrSFIASQGPLPpafegFWRMVWEQNSQSIVMLTNLVGLNKTKCHKYWPDktetyggvtvtlhqsevfagyenctfilskEKRSGS
||||||.....  ||  .||.||||.     ||.|..|......|||.... |...||. |||.                               . . .
dyinaspldlsyitp.rliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe..............................lredle

RIVRQFHFTVWPDKGVPQYATaVLAFRRKVRALNPR-DAGPVIVHCSVGVERTGAYIVIDAMLEQAKkSRTVDIRNYLIAIRKHRPHMVQTKEQYSFIH
| . |.... ||| |||  .. .| | . |.    . . |||.|||| || |||. .... || . . ...||. ... ..|..||.|||| .|| |..
rlgiqylylpwpDhgvpdlsi.llefvkfveealsedpggpvlVHCsaGvgRtGtlvaaylmlrgll.eslvdaldlvrelRlqrpgmvqtpsQyrfly

0042113 (Phosphotyrosine protein) phosphatases II 443-623 5.8e-43 142.4 In-house 2-184 (245) alignment
Range on Protein: 443-623
Range on HMM: 2-184/245.0
SVGEKPQNLHKNRFSDIIALNSCRVMLHKEHADEESDYINAVFLHAHRGRNAFIATQHPLLETVEDFWRMVTDYDIGTIVMLNNLHDQVAPESSEYWPDH
||...| | .|||.|||......|| |  .  |. |||||| . . .|  . |||||.|| |||||||||. ...| |||||.....   . . .|||..
svallpenkdknrysdilpydhtrvklspdggdldsdyinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywplg

GATKYGHIGISVLSKQKKGDVICVKPKVT--RKKKTHEVRHLHHVSWTDKCIPKVSRSVLDLLDEVQTSQQQCGNVPVLVQCR
. ..||.. . .|| ....|... . .||  ......||.|.|...| | ..|  ....||.|..|.. .....| |||| |.
esltygdftvtllseehlddytvrtlevtnlgddesrevihyhylpwpdhgvpdllellldflefvrkalaedsngpvlVHCs

0040439 (Phosphotyrosine protein) phosphatases II 442-623 2e-42 140.9 In-house 3-187 (249) alignment
Range on Protein: 442-623
Range on HMM: 3-187/249.0
KSVGEKPQNLHKNRFSDIIALNSCRVMLHKEHADEESDYINAVFLHAHRGRNAFIATQHPLLETVEDFWRMVTDYDIGTIVMLNNLHDQVAPESSEYWPD
.||...| |..|||..||......|| |.     . |||||| ...  .  ..|||||.|| |||||||||. ...|..||||..|         .|||.
ysvallpenkdknrypdilpydhsrvklsilpglflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywpl

HGATKYGHIGISVLSKQKKGDVICVKPKVT--RKKKTHEVRHLHHVSWTDKCIPKVSRSVLDLLDEVQTSQQQC-GNVPVLVQCR
 | ..||.. . .|| ..|.|... . ..|   ......|.|.....| |  .|.   ..||....|.. ....  . |||| | 
ggsleygdftvtllsvevkddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCs

subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 418-622 1.2e-41 137.6 In-house 13-215 (281) alignment
Range on Protein: 418-622
Range on HMM: 13-215/281.0
PMTGYALEFQRLNSVTSREIPVeeksVGEKPQNLHKNRFSDIIALNSCRVMLHKEHADEESDYINAVFLHAHRGRNAFIATQHPLLETVEDFWRMVTDYD
  .|.. |.. |...  ..  .      ....| .|||.|.|.| .  || ..........||||| |. . .| ...|||| |. .....||.|| ...
dnaGfieeyeklaaigvdntat....askadenvlknrYsnivaYDatrvkvtpneenkntDYinanfvpgykgekeyiatqgPvPaslvafWqmvweqk

IGTIVMLNNLHDQVAPESSEYWPDHG-ATKYGHIGISVLSKQKKGDVICVKPKV-TRKKKTHEVRHLHHVSWTDKCIPKVSRSVLDLLDEVQTSQQQCGN
. .|||. .  ..       ||||.  ..|||.. .. .....|   |. | |. ... .| ||..|....| |. .|. .. .|.  .||.  ...  .
vsaivmvtreieagklkChrYWPddnselkygdvtvkstaeeekatyierkfkleresgetreveqlaytaWPdhGvPattkellefrkevlkltekktk

VPVLVQC
.|... |
aplvihC

subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 440-622 7.8e-41 135.2 In-house 36-223 (305) alignment
Range on Protein: 440-622
Range on HMM: 36-223/305.0
EEKSVGEKPQNLHKNRFSDIIALNSCRVMLHKEHADEESDYINAVFLHAHRGRNAFIATQHPLLETVEDFWRMVTDYDIGTIVMLNNLHDQVAPESSEYW
|   ||.| .| .|||...|. |.  |..| ... ...|||||| ...........|..| || .||.||||.. .. . ||||| .| ..       ||
esidvgkkeankaknrlkeitlldddriiltekeslddsdyinasyvdgykrkkkyivaqgPlkntvadfWrliveekvstivmltklveggkdkCrqYW

PDHGAT--KYGHIGISVLSKQKKGDVICVKPKVTR---KKKTHEVRHLHHVSWTDKCIPKVSRSVLDLLDEVQTSQQQCGNVPVLVQC
|.  .   ..|.. . . |...  | |  | |..    .|... | ...  .| |. .|. . |.|.|...|| .|..  .||.|| |
pesktekkefgefsvelksektasdyieRklkisiededkesrtvlqyqltdWPdhGvpqfatsllslikrvqkdqkkdkgvpllVhC

subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 145-391 1.2e-40 134.5 In-house 28-277 (307) alignment
Range on Protein: 145-391
Range on HMM: 28-277/307.0
QFPWGAARKPANKNKNKNRYANIVAYDHSRVVLErVNGDeDLDYINASFIhGYDGTPRSFIASQGPLPPAFEGFWRMVWEQNSQSIVMLTNLVGLNKTKC
. | | . .  . | .|||| .. . |..|.|.. ..|    ||| | .. |    |. ||..||||  .   || |. ... .|..|| ... | | ||
ktpegvtveafsantdknryqdvkcqdkgrivvk.fdgl.asdyihanyl.giaikpkkficaqgplentqysfwamaiqekvesvimlckvielakikc

HKYWPD---KTETYGGVTVTL----HQSEVFAGYENCTFIL--SKEKRSGSRIVRQFHFTVWPDKGVPQYATAVLAFrrkVRALNpRDAGPVIVHCSVGV
..|||    .. ..|  . |.      .. .|  |..  .     .  ..|| .... .. |||.||||   . . .   . | .  |  ||.|||| ||
eqywpleegqklvfgeapntisvanlgakklapdedlinvttlkvdwaqksrtiqhlqwenwpdrgvpqinltainl...leavr.ydtnpvvvhcsaGv

ERTGAYIVIDAMLEQAKKS-RTVDIRNYLIAIRKHRPHMVQTKEQYSFIHSAVLEAL
 |.|. . |  . ..  .     |... .  .|..|.. .||. || ..|  .|| .
GrsGtivaislvqdkmiaGinckdmkklveelrsqrhyaiqteaqylylhrvlleyf

0045098 (Phosphotyrosine protein) phosphatases II 438-623 2.1e-40 134.3 In-house 21-214 (278) alignment
Range on Protein: 438-623
Range on HMM: 21-214/278.0
PVEEKSVGEKPQNLHKNRFSDIIALNSCRVMlhkehadeesDYINAVFLHAHrgRNAFIATQHPLLETVEDFWRMVTDYDIGTIVMLNNLHDQVAPESSE
.. | ... .. ||.|||..||......||           ||||| ... .  ...|||||.|| .||.|||||. ...| .||||..|..       .
ipseitpalylgnldknRykdilpydhsrVk..........dYINAsyidgy..pkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrekcaq

YWPDHGATKYGHIGISVLSKQKKGDVICVKPKVT------RKKKTHEVRHLHHVSWTDKCIPKVS--RSVLDLLDEVQTSQQ------------QCGNVP
|||..|   ||.. . .|| .  .|.. .. .||         ....|.||| ..| | ..|  .  .|.|.||....  ..            . .. |
ywpeggsltygdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsggp

VLVQCR
||| |.
vlVHCs

subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 155-389 3.8e-40 132.4 In-house 51-281 (290) alignment
Range on Protein: 155-389
Range on HMM: 51-281/290.0
A--NKNKNKNRYANIVAYDHSRVVLErvNGdEDLDYINASFIHGydgTPRSFIASQGPLPPAFEGFWRMVWEQNSQSIVMLTNLVGLNKTKCHKYWPDKT
   | . .|||| ..|  | .||.|.  .|  | ||. | ...|   .   || .||.|  .   .|||| ...   |||| .|.   |.||..|.|.| 
fdkntefkknrykdvvcndktrvilk..dG.ydGdyvhanyvkG...lkamfiltqGalkdtvidiwrmvlqekvaaivmlceliedGkakceqyypeke

---ETYGGVTVTLHQSEVFAGYENCTFILSKEKRSG-SRIVRQFHFTVWPDKGVPQYATAVLAFRRKVRALnprdAGPVIVHCSVGVERTGAYIVIDAML
    |.| .||.  ...          .  ..| || . ... ..   |||| |.. . |.|   | .| .    .|||.|||| |. |||... |.. |
GevltfGeitvlcseeddkdaniikktlsvrdkdsGkehklkhlkikswpdksvalstlallrtlrilrka....sGpvvvhcsaGiGrtGtfvaievgl

EQAKKSRTVDIRNYLIAIRKHRPHMVQTKEQYSFIHSAVLE
.   . . .|. .   |.|. |   ||   ||  .  ..|.
qilldGkeldlldlvralrnsrlnsvqvdiqylalveilld

subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 439-623 3.9e-40 132.8 In-house 40-225 (297) alignment
Range on Protein: 439-623
Range on HMM: 40-225/297.0
VEEKSVGEKPQNLHKNRFSDIIALNSCRVMLHKEHADEESDYINAVFLHAHRGrnAFIATQHPLLETVEDFWRMVTDYDIGTIVMLNNLHDQVApESSEY
. .. | ||  |..|.|...|.  .| ||.|.    | .|||.|| |... .    .|.|| |  .||.|||.|| |... ||||||.....   .   |
iqpqtvaekkvnfeksRYkniLPydssRvkLaivnddpdsDyvnasfvkgnkh..rlittqmPmkatvadfWamvldeqvstivmlnddnerdk.kcary

WPDHGATKYGHIGISVLSKQKKGDVICVKPKVTRKK--KTHEVRHLHHVSWTDKCIPK--VSRSVLDLLDEVQTSQQQCGNVPVLVQCR
|.|.| |..|.. . .|| ...   |  . .||. |  ... |.  ..|.| || ...    .|.|.|..||. . .|  . |.|| | 
WsdkgvttfGdvsvvllsvsereGfikrelevtkgkakarrvvkqyqfveWPdkaverkdsassllklisevrkdfsqnaegPllvhcl

0046846 (Phosphotyrosine protein) phosphatases II 180-389 9.3e-40 131.6 In-house 6-171 (176) alignment
Range on Protein: 180-389
Range on HMM: 6-171/176.0
VNGDEDLDYINASFIHGYDgtprsFIASQGPLPPAFEGFWRMVWEQNSQSIVMLTNLVGLNKTKCHKYWPDKTETYGgvtvtlhqsevfagyenctfils
   |.|||||||..| |.      .|| |||||  .. |..|..|.. . .|.||..| |.. ||. |||. ..                          
lgldldldyinanlilgsr.....piatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgi.......................

kekrsgsrivrQFHFTVWPDKGVPQYaTAVLAFRRKVRALNPRDaGPVIVHCSVGVERTGAYIVIDAMLEqakkSRTVDIRNYLIAIRKHRP-HMVQTKE
           |.... ||| |||.. ...| . . .|    .. |||.|||| |. |||...... .      .. ... . |  .|..|| ..||| |
...........qylhlpwpDhgvpdl.elllellefirealkeg.gpvlVHCsaGigRtgtlvaayllel....ekglsveealalvreqRplgavqtpe

QYSFIHSAVLE
|| |.. ..|.
Qyrflyefell

subfamily_PTPRG_pd Subfamily PTPRG 420-624 9.4e-40 131.3 In-house 19-229 (563) alignment
Range on Protein: 420-624
Range on HMM: 19-229/563.0
TGYALEFQRL-NSVTSREIPVEEksvGEKPQNLHKNRFSDIIALNSCRVMLHKEHADEES-DYINAVFLHAHRGRNAFIATQHPLLETVEDFWRMVTDYD
.|.. ||. | . ..|.....|     .||.| .||| ..|.| .. || |..    ... ||||| ... ..  .||||||.|| .|..|||||. .  
igfseefealqsetiskdldaeh...sqkpenkrKnRylnivaydrsRvklsplpgkkkklDYinAnyidGyqkskafiatqgplkdtfddFWrmiWeqn

IGTIVMLNNLHDQVAPESSEYWPDHGATKYGHIGISVLSKQKKG----DVICVKP-KVTRKKK---THEVRHLHHVSWTDKCIPKVSRSVLDLLDEVQTS
  .|||. || .. . .   |||  .. .||.. .   .....       . .|  |. .||.    ..||. |  .| |.. |. |  ||      ...
vaiivmitnlvergrrkcdvYWPkdesetygalqvtlieeevlalytvrtlviknlklkkkkqcdteklvrqyhytkWPdhgvPehslpvLifvkkssaa

QQQ-CGnvPVLVQCRY
...  |  |..| |..
nkaeaG..PivvHcsa

subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 444-623 1.1e-39 131.2 In-house 43-220 (315) alignment
Range on Protein: 444-623
Range on HMM: 43-220/315.0
VGEKPQNLHKNRFSDIIALNSCRVMLHKEHADEESDYINAVFLHAHRGRNAFIATQHPLLETVEDFWRMVTDYDIGTIVMLNNLHDQVAPESSEYWPDHg
|  | .| .|||. .||| .  || |     |..|||.|| |.  .  .. .||.| |. ..|.||||.| ..|||.||||.|| ..    . .||||. 
vakkienkqknryiniiaydksrvqlpllendphsdyvnanfidGynkkrryiaaqgpnvasvkdfwrlvfeedigkivmltnlvegekrkaekywpdk.

ATKYGHIGISVLSKQKKGDVICVKPKVTRKKKTHEVRHLHHVSWTDKCIPKVSRSVLDLLDEVQTSQQQCGnVPVLVQCR
   ||.| ..  |.... .. .    |. ... .||  ||. || |  .|| . ....|   |.  ...    ...| |.
kviyGkitvtrkseevnteytvrtlsvvfgdnirevvqlhytswpdmgvpkytiplmnlirtvkqhhtnsv.gaivvhcs

0049772 (Phosphotyrosine protein) phosphatases II 157-392 6.1e-39 130.0 In-house 45-281 (314) alignment
Range on Protein: 157-392
Range on HMM: 45-281/314.0
KNKNKNRYANIVAYDhSRVVLERVNGDeDLDYINASFIHGYdgtpRSFIASQGPLPPAFEGF----------WRMV--WEQNSQSIVM------------
.|..|||| .|. .| .||.| ..... . ||||||...|.    ..|||.||||.  .. |          ||||  ...|.  |||            
lnrdknryldilpad.nrvilpglpvs.gsdyinasyvdgf....lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivmsrdevladelsr

---------LTNLVGLNKTKCHKYWPDKTetyggvtvtlhqsevfagyenctfilSKE--KRSGSRIVRQFHFTVWPDKGVPqYATAVLAFRRKVRALnp
         |..| |..   . .....                            .    .   .| . ... . .|| ..|     ...| . ....  
LdaAlgKtpllildgngneptaadlellk..........................eelydpelferlgikylripvpDgsap.lledfdeflefieea..

RDAGPVIVHCSVGVERTGAYIVIDAMLEQAKksrtVDIRNYLIAIRKHRP-----HMVQTKEQYSFIHSAVLEALT
.. |||.|||. |. ||| ..|.. .. . .    |...  |  .|. ||     ..... ||| ||. |.||.| 
dkggpvlvHCkaGkgRtgtfvvaaylmkllg....vsleealedvrlkRpinpnpgfieqleqyefilealleylk

0043147 (Phosphotyrosine protein) phosphatases II 183-384 9.4e-39 128.2 In-house 2-154 (172) alignment
Range on Protein: 183-384
Range on HMM: 2-154/172.0
DEDLDYINASFIHGYDGTPRsFIASQGPLPPAFEGFWRMVWEQNSQSIVMLTNLvglnktkchkywpdktetyggvtvtlhqsevfagyenctfilSKEK
||. ||||||....|  ..| ||| ||||.  .. ||||..|.. . ||.||.|                                           . .
degsdyinasyldlyyipdr.fiatqgplrntladfwrmlkelgithivnltel..........................................lydp

RSGSRIVRQFHFTVWPDKGVPqYATAVLAFRRKVRA-LNPRDAGPVIVHCSVGVERTGAYIVIDAMLeqakksRTVDIRNYLIAIRKHRPHMVQTKEQYS
   .| . |.... ||| |||  .  .| | . ..  |. .. |||.|||| || |||. .... ||      . ... . .  .|..||..||...|| 
ellerlgiqylylpwpDhgvp.llellleflefidellalspggpvlVHCsaGvgRtgtlvaaylml......lglsleeavalvrekRpgavqnpsqyr

FIH
|..
fly

0037934 (Phosphotyrosine protein) phosphatases II 444-624 2.8e-38 127.3 In-house 4-187 (243) alignment
Range on Protein: 444-624
Range on HMM: 4-187/243.0
VGEKPQNLHKNRFSDIIALNSCRVMLhkehadEESDYINAVFLHAHrGRnaFIATQHPLLETVED----FWRMVTDYDIGTIVMLNNLHDQVAPESSEYW
.. .|.||.|||.|||....  || |      | |||||| .     .|  .||||.|| |||||    ||||. ...|..||||..| .  .    .||
iallpenlsknrysdilpydhsrvkl......egsdyinanliyvt.pr..liatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqyw

PdhGATKYGHIGISVLSKQKKGDVICVKPKVTR---KKKTHEVRHLHHVSWTDKCIPKVSRSVLDLLDEVQTSQQQ-------CGNVPVLVQCRY
|  | . ||.. . .|| . ..|..  . ....   .. |..|.|.|...| | ..|    ..||.||||.. ...        .. |||| |. 
p..gevtygdftvtllseehlddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsa

subfamily_PTPN9_pd Subfamily PTPN9 443-612 5.1e-38 125.8 In-house 35-208 (297) alignment
Range on Protein: 443-612
Range on HMM: 35-208/297.0
SVGEKPQNLHKNRFSDIIALNSCRVMLHKEHADEESDYINAVFLHAHRGRNAFIATQHPLLETVEDFWRMVTDYDIGTIVMLNNLHDQVAPESSEYWP--
 . ... ||.|||..|.. ... ||.| |.. ||.|||||| |.  .. ..|||||| || .||.|||||| . .. .|||   . ..     ..|||  
lasklranleknrytdvlcydetrvvlakvdedeasdyinanfvdGykqkkafiatqGplkktvsdfWrmvWeqevlvivmttrvvergrlkcgqyWple

DHGATKYGHIGISVLSKQKKGDVICVKPKVT--RKKKTHEVRHLHHVSWTDKCIPKVSRSVLDLLDEVQTSQQQ
.. ....|.. .|... ... |    . ...  ..... .| |   .|| |  .|. . |.||.|..|.  | .
eessaefgdlsvsnveveeeedykvrvleiknvkteesrkvthfqflsWPdyGvPssaaslldvlekvrekqal

subfamily_PTPN6_pd Subfamily PTPN6 396-622 6.4e-38 125.5 In-house 2-234 (306) alignment
Range on Protein: 396-622
Range on HMM: 2-234/306.0
TEIQSEKYNQAMQKLASVNGKFPMTGYALEFQRLNSVTSREipVEEKSVGEKPQNLHKNRFSDIIALNSCRVMLHkEHADEESDYINAVFLH--AHRGRN
|.. ... .| ...|   . ..  .|.  ||..|.   ...  . ... |.||.| .|||.  |.  .  ||.|. |.   .|||||| ...  ..  ..
tsllakeieqrvselekeeeslekagfeeefeelqqeeakk..llsrkegakpenkeknryknilPfDhtrvilk.epsvpgsdyinanyikkevkgsdk

AFIATQHPLLETVEDFWRMVTDYDIGTIVMLNNLHDQVAPESSEYWPDHGAT-KYGHIGISVLSKQKKGDVICVKPKVT---RKKKTHEVRHLHHVSWTD
..||||  | .||.|||||| . .   |||. .  ..     . ||||. .. .||.| .. .|.... | |  . .|.   .||...||...|. || |
syiatqgclettvsdFWrmvwqensrvivmttkevErgkekCarYWPdeeekeeyGkisvtnvseksladYilRelsvskkkkkkeerevfqyhfksWPd

KCIPKVSRSVLDLLDEVQTSQQQCG---NVPVLVQC
. .||    |||.|..|.. |...    . |..| |
hgvpkdpgavLdfledvnrkqeeleeaeagpivvhC

subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 443-623 1.2e-37 124.2 In-house 36-217 (515) alignment
Range on Protein: 443-623
Range on HMM: 36-217/515.0
SVGEKPQNLHKNRFSDIIALNSCRVMLHKEHADEESDYINAVFLHAHRGRNAFIATQHPLLETVEDFWRMVTDYDIGTIVMLNNLHDQVAPESSEYWPD-
.| ..  | .|||. .|. ..| || |   . . .|||.|| ....    .|.||.| |.  .|.||||.| .... ||.|...|...     ..|||| 
tvaqeeinfkknryknilPydsvrvklevindnPhsdyfnasyipsfdndkayiasqgPnkasvddfWrlvlqenvttiamvtklkegdkikcgkyWPdk

-HGATKYGHIGISVLSKQKKGDVICVKPKVTRKKKTHEVRHLHHVSWTDKCIPKVSRSVLDLLDEVQTSQQQCGnVPVLVQCR
   . |.|.| ....| .  .. |  | .|.. .... |   |   | || .|| ..|.| |. ||.....|    |... | 
pgdsvkfGsikvelvsleactggikrkltvlkgddsrtvtqfhfteWPdkGvpkhtssllklikevkadhgqyt.hpliihcs

subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 154-389 1.7e-37 123.9 In-house 29-257 (267) alignment
Range on Protein: 154-389
Range on HMM: 29-257/267.0
PANKNKNKNRYANIVAYDHSRVVLERVNGDedldYINASFIHGYDgTPRSFIASQGPLPPAFEGFWRMVWEQNSQSIVMLTNlVGLNktKCHKYWPDK--
 |.||...||. . . ||..||.|   . .    |||||...||  | . ||. |.||  .   |. .. .|.   ||.||. |. .  . ...|| |  
iaeknqernrlddnlpyddtrvilrtkeee....yinasyvegyk.tknafivtqdplkntitdfltvihdqkvpvivlltk.vftd..nirlfwPPkmg

-TETYGGVTVTLHQSEVFAGYENCTFILSKeKRSGSRIVRQFHFTVWPDKG-VPQYATAVLAFRRKVRALNprDAGPVIVHCSVGVERTGAYIVIDAMLE
 .. |  .||     .    |.  |. |   |   .. |  ...  |  .     |   ...   | .  |     |..|.|| || |.|...|||..||
qakkyqdltvehslekeendyqiitlelkf.knesahnvtlyyykkwnintnnkpylkplfgilaknqlen..gnrPlvvacsdGvGrsGtflvidsqle

QAKKSRTVDIRNYLIAIRKHRPHMVQTKEQYSFIHSAVLE
.||.  ..|| ..|  ||. |. .|.|||.| .||  . |
raktegvsdifdflrkirsqriglvdtkeryiyihellae

subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 438-623 2.7e-37 123.3 In-house 32-218 (315) alignment
Range on Protein: 438-623
Range on HMM: 32-218/315.0
PVEEKSVGEKPQNLHKNRFSDIIALNSCRVMLHKEHADEESDYINAVFLHAHRGRNAFIATQHPLLETVEDFWRMVTDYDIGTIVMLNNLHDQVAPESSE
.. .. |. ...| .|||. .|. |.| ||.|     . .|||||| ....    .|.||.| ||  .|.|||||| .... ||||.......   .   
diyrqrvaretinfkknryknilPldsarvkleviddsPdsdyinasyiksvdddkayiasqgPlkasvddfwrmvlqekvttivmvtkkqegdkikcrq

YWPD--HGATKYGHIGISVLSKQKKGDVICVKPkVTRK-KKTHEVRHLHHVSWTDKCIPKVSRSVLDLLDEVQTSqQQCGNVPVLVQCR
||||    ....| | ...|| .  .| .  |  |||| .... |   .   | || ..| . |.| |. ||... ..  . ..|| | 
ywPdrkadsvefGsikvellsleadtdgvarkl.vtrkseesrtvtqfqftewPdkGvdkqtssllklikevkad.ngkkefsllvhcs

subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 421-622 5.5e-37 122.6 In-house 24-228 (325) alignment
Range on Protein: 421-622
Range on HMM: 24-228/325.0
GYALEFQRLNSVTSReipveEKSVGEKPQNLHKNRFSDIIALNSCRVMLHKEHADEESDYINAVFLHAHRGRNAFIATQHPLLETVEDFWRMVTDYDIGT
|.| ||. | |. .       | |  ||.|  |||| ...||.  ||.|   . | .|||||| .|. ..... |.|.| || .|..|.||.| |.    
gfahefgllpsddgi.....akkvamkpenkaknrfknvvaldksrvvletkkddpssdyinasylrddkkkdvflaaqaPltatindlWrlvldWrcsv

IVMLNNLHDQvAPESSEYWPDH--GATKYGHIGISVLSKQKKGDVICVKPKVTRKKK--THEVRHLHHVSWTDKCIPKVSRSVLDLLDEVQTSQQQ----
.|.|| |  .   . . |||..   . ..| . ... . ..  | .  . .| . ||  |  |. ... || |   .|   ... .|. |.. ...    
vvvlneldlg.kdrcavywpkemgksktfGglevklrtieeisdyvhrvldvkqvkkGetrsvkqfqlqswddmGvqkrpatlisilqlvkavservtan

-CGNVPVLVQC
  .  |.|| |
tkastpilvhc

0049260 (Phosphotyrosine protein) phosphatases II 201-384 6.9e-37 121.8 In-house 8-143 (152) alignment
Range on Protein: 201-384
Range on HMM: 8-143/152.0
PRSFIASQGPLPPAFEGFWRMVWEQNSQSIVMLTNLVGLNKTKCHKYWpdktetyggvtvtlhqsevfagyenctfilskekrsgsrivrQFHFTVWPDK
|. ||| |||.|  .. ||||..|.. . |||||.|. |.| ||..|.                                          |.... ||| 
pfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi..........................................qylhlpwpDh

GVPQYATAVLAFRRKVRALNPRDAGPVIVHCSVGVERTGAYIVIDAMLeqakksRTVDIRNYLIAIRKHRPHMVQTKEQYSFIH
|||. .  .| . . .. |. .. |||.|||| || |||...... ||      . |.. ...  .|..||..|....|. |..
gvpdlsqlllflllfieklaldkggpvlVHCsaGvgRtgtlvaaylml......lgvsleeavalvrekRpgavpnpgqlrfly

subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 419-622 2.2e-36 120.3 In-house 19-218 (287) alignment
Range on Protein: 419-622
Range on HMM: 19-218/287.0
MTGYALEFQRLNSVTSREipvEEKSVGEKPQNLHKNRFSDIIALNSCRVMLHkehaDEESDYINAVFLHAHRGRNAFIATQHPLLETVEDFWRMVTDYDI
 .|.   |. |..|| ||   .|  ..  .|| .|||...|.  .  ||.|.    .|. |||||||. ... ..|||... |. .|. .||... |  .
negfknqftvleqvtqre...devthniasqnkdknRltqilvpdnyrvllk....gehpdyinavfidgykekkafiiaesPmfntarnfWkliddrnv

GTIVMLNNLHDQVAPESSEYWPDHGATKYGHIGISVLSKQKKGDVICVKPKVTRKKK---THEVRHLHHVSWTDKC-IPKVSrSVLDLLDEVQTSQQQCG
 .|||| .....      .|||.. .. .|.  |..|..... ..|  | .|..|.|   ...|.  .  .| ..  ...   ..| ...|   .|.. |
taivmlcqekendeevcyqyWpeeksvvlGeyniellneevnagyierklevknknkagdkqqvkqyqitnWdstgkvtepq.tillvieemyktqrkrg

NVPVLVQC
| ...| |
ntsivvhC

0044763 (Phosphotyrosine protein) phosphatases II 170-388 9.7e-36 118.4 In-house 2-168 (178) alignment
Range on Protein: 170-388
Range on HMM: 2-168/178.0
YDHSRVVLERVNGDEDLDYINASFIHGYdgtprSFIASQGPlppafEGFWRMVWEQNSQSIVMLTNLVGLNKTKCHKYWPDKTEtyggvtvtlhqsevfa
.|..||.|. . | |  ||||||.| ..      ...|..|     . ......|.. ..||.||. . |.. ||..|||....                
ldrtrvllsnleglersdyinaseilpg.....lylgslpp.....addlellkelgithivnlteelelgflkcdpywpeeag................

gyenctfilskekrsgsrivRQFHFTVWPDKGVPQYATAVLAFRRKVRALNPRDAGPVIVHCSVGVERTGAYIVIDAMLEQakksrTVDIRNYLIAIRKH
                     |.... .|| |||.    .|.| . .... ... |||.|||| || |.|. .... |...      ... . .  .|..
....................iqylhipipDhgvpdllehflefvefieealdekggpvlVHCsaGvgRsgtlvaaylmkkl.....glsleeaielvrer

RPhMVQTKEQYSFIHSAVL
|| .|.. .|. ...   |
Rp.ivpnpgqlrqLyefel

subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 125-390 1.4e-35 117.5 In-house 18-286 (305) alignment
Range on Protein: 125-390
Range on HMM: 18-286/305.0
AKMHGGIRLET-EYKKFNNgqqFPWGAARKPANkNKNKNRYANIVAYDHSRVVLervNGDEDLDYINASFIHGyDGTPRSFIASQGPLPPAFEGFWRMVW
 |.  |.| |    |.||.   |    | | |. ...|||| ..   |. || |   .|    .|| | ..      |. || .| ||  .   || | .
ekgpaglraefvamkrfnd...fekmkafkeaq.eagknrykdvgcldnnrvkl...egpwpheyihanyvst.ptnpkrfictqaplektcadfwymcl

EQNSQSIVMLTNLVGLNKTKCHKYWPDKT-------ETYGGVTVTLHQSEVFAGYENC------TFILSKEKRSGSRIVRQFHFTVWPDKGVPQYATAVL
... ..| || ||.     ||..|.. |        |    ..| .  |. .   ...      | .. .   . .| | ..|.  |||.|||   .|.|
qdkveaifmlcnllekgakkcleyfaskdkdvlefeekgqkisvkfessvtlkfrkdakakvtetvlviegpgekarkvthyhwidwpdrgvpaadlail

AFRRKVRALNprdaGPVIVHCSVGVERTGAYIVIDAMLEQAKKSRTVDIR-NYLIAIRKHRPHMVQTKEQYSFIHSAVLEA
 .  | |..     ||..|||| |. |||. .... .|.|    . ..     |  ||. |   .|| .|| |.|  .|. 
ellekarpsk....gpivvhcsagigrtgsvvmleyildqllagqiiedtdkilqkireqrnnsiqtdaqylfvhqvilny

subfamily_PTPN3_pd Subfamily PTPN3 441-622 4.2e-35 116.0 In-house 32-215 (280) alignment
Range on Protein: 441-622
Range on HMM: 32-215/280.0
EKSVGEKPQNLHKNRFSDIIALNSCRVMLHKEhadeESDYINAVFLHAHR----GRNAFIATQHPLLETVEDFWRMVTDYDIGTIVMLNNLHDQVAPESS
. |.  ||.||.|||. ||.. .. ||.|...    |.||||| ..          | .|||| || .|..|||.|| . .. .|||| .| ..      
aisaarkpenlsknryrdilpydatrvklkes....etdyinanyvnmeipstglvnryiatqGPlaktatdfWqmvweqksslivmlttlverGrvkCh

EYWPDHG-ATKYGHIGISVLSKQKKGDVICVKPKVTRKK--KTHEVRHLHHVSWTDKCIPKVSRSVLDLLDEVQTSQqQCGNVPVLVQC
.|||...  ..||.. . . .....  ..  .  ...|.  . ... .| ...|.|...|. | ..|.....|.. . .  . ||.| |
qyWPetedeleygefsvkcekedetksyvlrelvlkdketkeerkilqlqylaWpdhgvPddsadflefvervrklr.sgkeePvvvhC

subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 419-622 7.3e-35 115.2 In-house 19-223 (290) alignment
Range on Protein: 419-622
Range on HMM: 19-223/290.0
MTGYALEFQRLNSvTSREIPVeekSVGEKPQNLHKNRFSDIIALNSCRVMLH--KEHADEESDYINAVFLHAHRGRNAFIATQHPLLETVEDFWRMVTDY
..|.  .|..|.| ...|  |    ||  ..| ..|||..|.  .  |..|.   .| | . .||||.... .. ....|||| |. .|. |||... . 
negfrnqfkmlds.gesehtv...tvgltssnkllnRfanivvyddnritLrpisghkDCtneyinAcyikgykekkqyiatqgpvsntlvdFWkliwqe

DIGTIVMLNNLHDQVAPESSEYWPDHGATKYGHIGISVLSKQKKGDVICVKPKVTRKKK---THEVRHLHHVSWTDKCIPKVSRSVLDLLDEVQTSQQQC
..  |||| |  ..   .   ||||.....||.. | .|. ..  . |  | .|. |..   ...| ...  .| ..   .   ..| .. |..  | . 
kvtiivmltniieegkvkCqqYWpdsdtkaygefsikllneetlneyierklevknknsagakqsvtqyqitnwdstgkvtnpqtillvieemyktqrkr

GNVPVLVQC
|| ...| |
gntsivvHC

subfamily_PTPN23_pd Subfamily PTPN23 420-622 1.9e-34 113.8 In-house 15-219 (288) alignment
Range on Protein: 420-622
Range on HMM: 15-219/288.0
TGYALEFQRLNSVTSREipVEEKSVGEKPQNLHKNRFSDIIALNSCRVMLHkehaDEESDYINAVFLHAH-RGRNAFIATQHPLLETVEDFWRMVTDYDI
|.   .|. |..   .|   ...|.     . .|||. ||.  .. ||.|.    ... ||||| |..    |   ||||| || .|. |||.|| .   
taldkkfkeleqkqdke..arkrsiaiaklyseknrsrdilPyDhnRvklr....gskDDYinAsfvkdlspgcPdfiatqaPlqstlnDFWlmvyeqks

GTIVMLNNLHDQVAPESSEYWPDH--GATKYGHIGISVLSKQKKGDVICVKPKVT--RKKKTHEVRHLHHVSWTDKCIPKVSRSVLDLLDEVQT---SQQ
 .|||| . ...  |. ..||| .   ..|.|.. ... |... . ..  . |..  .......|.||.  ||..  .|.   ..|..||||..   ..|
sviVmllskeelgkpkvdrYwPedkgetvkfgdlsvtlksvretethvervlkletldadavksvshlqltsWpelGvPasPetllqfldevesayeavq

QCGNVPVLVQC
.  ..|..|.|
rksktPlvvhC

subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 437-622 3.4e-34 113.2 In-house 14-208 (274) alignment
Range on Protein: 437-622
Range on HMM: 14-208/274.0
IPVEEKSV-GEKPQNLHKNRFSDIIALNSCRVMLHKEHADEE-SDYINAVFLHAHRG-RNAFIATQHPLLETVEDFWRMVTDYDIGTIVMLNNLHDQVAP
.|.. .    . . . .|||. .|.  .  ||.|..|....| |.|||| ...  ..  .|..||| || .||.|||||.   ..  |||| .|...   
lPlnfdqeeldvfgsqtknryktilPnensrvllesessededssyinanyikGydeeskayvatqGPlpntvadfWrmiyqeevqvivmltklkeaneq

ESSEYWPDHGAT----KYGHIGISVLSKQKKGDVICVKPKVTRKKKTHEVRHLHHVSWTDKCIPKVSRSVLDLLDEVQTSQQQCGNV--PVLVQC
  ..|.||.  .    .||.. | | .. .. |    |  .   .....| |  . .| |.  |.  ...|||..||..|...  .   ||.| |
kCavyfPdaedyeiserygdveikvekiverndysvrklvlkylerersvkhywytdWPdhksPddantlldlvleveesreeenaklapvvvhC

subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 150-390 9e-34 111.5 In-house 47-288 (305) alignment
Range on Protein: 150-390
Range on HMM: 47-288/305.0
AARKPANKNKNKNRYANIVAYDHSRVVLERVNgdeDLDYINASFIHGYDGTPRSFIASQGPLPPAFEGFWRMVWEQNSQSIVMLTNLVGLNKTKCHKYWP
 | . |. .. ||||... . |.| | |.. .     ||| | ..       . ||..||||  . . || || ... . |||| . | | | || .|||
nanqsadiaitknryqdvpcqdqsavkldkps...psdyihanyvgcpmipekrficaqgpldqtidefwwmviqnkveqivmlcktvelgklkcaqywp

----DKTETYGGVTVT-LHQSEVFAGYENCTFILSKEKRSGSR--IVRQFHFTVWPDKGVPQYATAVLAFRRKVRAlnprDAGPVIVHCSVGVERTGAYI
    .| |  .|. |  .  |  .    .    | .   ||..   ||....| |||.|||    . | .   .|        |..|||| |. |||. .
aaqgeklelksgivvenvsgskpmerdaeiqitllnltysgdqkmsvrhlqwtewpdrgvppckltslellsairg....skvpivvhcsagigrtgtiv

VIDAMLEQAKKSR-TVDIRNYLIAIRKHRPHMVQTKEQYSFIHSAVLEA
 |. .||.  . .    . . . |.| .| . .|.  || |||  .|. 
aieyilekiaenkpcppmpelvkalrdqrafsiqndvqylfihrvmlny

subfamily_CG42327_pd Subfamily CG42327 157-317 1.4e-33 110.9 In-house 27-191 (319) alignment
Range on Protein: 157-317
Range on HMM: 27-191/319.0
KNKNKNRYANIVAYDHSRVVLERVNGDEDLDYINASFIHGYDGTPRSFIASQGPLPPAFEGFWRMVWEQNSQSIVMLTNLVGLNKTKCHKYWPD-----K
  |.|.|..|.|   ..||||.|.  |.   |..||.. ||| .| |.||.| .|  .   |||.||||.|. || ||.|  |   .| .|.|       
tskdksrvinvvPlPetrvvlqrigdddkdeyldasyvrGyddapnsyiaaqvsledsssdfwrtvweqqsrvivqltdlselGikvcaeylPtketldn

TETYGGVTVTLHQSEVFAGYENCTFILSKEKRSGSRIVRQFHFtVWPDKGVPQYATAVLAFRRKVR
|..|| . ||| . ||   |   |..| . ... || .  . .  |.. .||   .|..|   .||
tslyGdilvtlkgrevkdryaistlllkrvdkeesrelthywy.kwleaevPaeeaaliamllevr

subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 423-622 1.5e-33 111.5 In-house 37-231 (319) alignment
Range on Protein: 423-622
Range on HMM: 37-231/319.0
ALEFQRLnsvTSREIPVEEKSVGEKPQNLHKNRFSDIIALNSCRVMLHKEHADEESDYINAVFLHAHRGRNAFIATQHPLLETVEDFWRMVTDYDIGTIV
  ||.|.   . . ..  ...  . .||  |||. .|.| .  .| |..    | |||||| |.  .. .. .||.| || .|..|||||. .|.. |||
evefrra...cklgvnladqtfanldqnkdknriinilafdknvvklerliGeefsdyinasfvtGyqrkdkyiaaqGPldntladfWrmiweyncstiv

MLNnlhdqvAPESSEYWPDHGATKYGHIGISVLSKQKKGDVICVKPKVTR---KKKTHEVRHLHHVSWTDKCIPKVSRSVLDLLDEVQT-SQQQCGNVPV
.|           |.||| ..  |...  ..| | ..  . .  . ....   .|   ...  |   | |.  |. .  .. |.. |.   ... .. ..
llt......kdkcsqywplkivikeerfkvkvdsveetaeyvvrdielsedgkekdirkitqfhflGwpdvGvpdypsdlmrlvkkvrhltskenhrani

LVQC
.| |
vvhc

subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 434-622 3.4e-33 110.3 In-house 9-195 (284) alignment
Range on Protein: 434-622
Range on HMM: 9-195/284.0
SREIPVEEKSVGEKPQNLHKNRFSDIIALNSCRVMLHKEHADEESDYINAVFLHAHRGRNAFIATQHPLLETVEDFWRMVTDYDIGTIVMLNnlhdqvAP
 . ..  ...  . .||  |||. .|.| .  .| |..    | |||||| |.  .. .. .|||| || .|..|||||. .|.. |||.|         
klgvngtdqtfanldqnkdknrighilafdknvvklerliGeefsdyinasfitGyqrkdkyiatqGPldntladfWrmiweyncstivllt......kd

ESSEYWPDHGATKYGHIGISVLSKQKKGDVICVKPKVTR---KKKTHEVRHLHHVSWTDKCIPKVSRSVLDLLDEVQT-SQQQCGNVPVLVQC
  |.||| ..  |...  ..| | ..  . .  . ....   .|.  ..|  |   | |.  |. .  .. |.. |.  .... .. ...| |
kcsqywplkivikeerfkvkvdsveeseeyvvrdielsedgkekdirkirqfhflgwpdvgvpdypsdlmrlvkkvrhltskenhranivvhc

subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 157-389 9.6e-33 108.0 In-house 36-267 (281) alignment
Range on Protein: 157-389
Range on HMM: 36-267/281.0
KNKNKNRYANIVAYDHSRVVLER-VNGDEDLDYINASFIHGyDGTPRSFIASQGPLPPAFEGFWRMVWEQNSQSIVMLTNLVGLNKTKCHKYWPDKTE--
 |..||||.|| . | ||| |.  .   .  ||| | .|.      | .| .|||   .   ||||.|..|. .|||| ...  |. || .|.| ..   
vnnkknrylnipcldisrvqlkvkmpnknstdyihanyirs.pflkrgyiltqgpkketradfwrmiwqenttaivmlcqfletnrekcaeyfprnahcc

-TYGGVTVTLHQSEVFAGYENCTFILSKEkrSGSRIVRQFHFTVWPDKGVPQYATAVLAFRRKVRAlnpRDAgPVIVHCSVGVERTGAYIVIDAMLEQAK
  .  ..|.  .| |        . || |    .|.. .. .  |||  ||. .  .|   ||.||   | . | ..||| || |.|. . ..  |.  .
lqfdklsvsyedstvnkslvttrlnlsye..getrlithwlwkewpdwqvpessevmlkilrkira...rst.ppvihcsagvgrsgtlmaveialqsih

KSRTV-DIRNYLIAIRK-HRPHMVQTKEQYSFIHSAVLE
   |. ||.. .  .|   |   ||| .|| .|   .|.
shftlpdikqivshlrvtgraasvqtlqqymliwkvlld

subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 153-399 1.9e-32 107.1 In-house 47-297 (310) alignment
Range on Protein: 153-399
Range on HMM: 47-297/310.0
KPANKNKNKNRYANIVAYDHSRVVLErVNGDEDLDYINASFIHGyDGTPRSFIASQGPLPPAFEGFWRMVWEQNSQSIVMLTNLVGLNKTKCHKYWPD--
.  .|.  ||||...|  | ||| |. ..     ||| | ...  .    .|| |||||  .   ||||.... ..||..| . .   . ||  |||   
eaykkymhknrysdvvcldtsrvklk.idksryedyihanyvkt.nylrstficsqgplqhtiidfwrmifqeraesilllckvgeegrpkcvgywpslg

KTETYGGVTVTlHQSEVFAGYENC----TFILS----KEKRSGSR--IVRQFHFTVWPDKGVPQYATAVLAFrrkvRALNPRDAGPVIVHCSVGVERTGA
 ||||| . ||   ||    .| |    ||.       |. .  .   |   ..  |||.|||.     .      | |     ||..|||| |..|...
vtetygcirvt.nlsesseefeicnlavtfvpdnvpvdeqpanlkelrvslikwpnwpdrgvpdekchtvpq....rllaqvrhgpcvvhcsagkdrlyv

YIVIDAMLEQAKKSRTVDIRNYLIAIRKHRPHMVQTKEQYSFIHSAVLeALTCGNTEIQ
 . ..  ......   ||. .    ..|.|   .||. || .|.   . ... |.||. 
vvalklkidkldrglkvdaeevktellksraiciqtelqyliidrvri.ifargeteva

subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 272-415 4e-32 106.1 In-house 78-218 (440) alignment
Range on Protein: 272-415
Range on HMM: 78-218/440.0
ENCTFILSKEkrsgSRIVRQFHFTVWPDKGVPQYATAVLAFRRKVRALN-PRDAGPVIVHCSVGVERTGAYIVIDAMLEQAKKSRTVDIRNYLIAIRKHR
 |...| . |    || ..|.|.  |||||||..|  || . . |   .     ||..||||.|. |||  |..|..| .||.|  .|| ... ..|. |
inasyingie....srtlkqyhyqgwpdkgvpkfagpvlkmiqdvnesqekagngpllvhcsagagrtgviiavdsilreakrsdqidifsfinsmrnnr

PHMVQTKEQYSFIHSAVLEALTCGNTEIQSEKYNQAMQKLASVNG
|.|||| |||.|.| ||||.| ||.| |  .   . ....   | 
pqmvqtpeqyafvheavlegllcgdtliledditerveqiqwpnp

0051082 (Phosphotyrosine protein) phosphatases II 186-388 4.4e-32 106.1 In-house 3-150 (151) alignment
Range on Protein: 186-388
Range on HMM: 3-150/151.0
LDYINASFIHGYdgtprsFIASQGPLPpafeGFWRMVWEQNSQSIVMLTNLVGLNktKCHKYWPDKTetyggvtvtlhqsevfagyenctfilskekrsg
 ||||.|.. |.      ...|.|||.     |.....|.. ..||.|....  .  .|..|.|.                                   
sdyinfsyvtgg......lyrsggpla....dflellkelgiktivnlrseeerg..ycpeylpelg.................................

sRIVRQFHFTVWPDKGVPQYATAVLAFRRKVRAlnpRDAGPVIVHCSVGVERTGAYIVIDAMLEQakksrtVDIRNYLIAIRKHRPHMVQTKEQYSFIHS
 . |...... ||| |.|..  |||.| .....    . |||.|||| |. |||. .... ||..      |..   |  .|..||..||...|. |.. 
.ievlhipildwpdpglplsfdavleflellld...kkngpvlvHCsaGkgRTGtlvalylmllg......vsleealeeyrlkrpgvvqpnqqflfqlf

AVL
|.|
all

subfamily_PTPRN_pd Subfamily PTPRN 440-623 5.3e-32 105.7 In-house 46-232 (297) alignment
Range on Protein: 440-623
Range on HMM: 46-232/297.0
EEKSVGEKPQNLHKNRFSDIIALNSCRVMLHKEHADEESDYINAVFLHAHRGRN-AFIATQHPLLETVEDFWRMVTDYDIGTIVMLNNLHDQVAPESSEY
. |.|.....|..||| ..... .  || |..| ..|.|||||| ..  |  |. |.|||| || .|| |||.|| .  .  ||.| .|...   . ..|
stkevakaeknvkknrskavlpydhsrvklkeeasaeksdyinasaildhdprapayiatqgplastvadfwqmvweqGvvvivnltrleeegvkqckry

WPDHGATKYGHIGISVLSKQKKGDVICVKP---KVTRKKKTHEVRHLHHVSWTDKCIPKVSRSVLDLLDEVQTSQQQcGNVPVLVQCR
|||.|.  |.   . ..|.    |   |.    |  ....|  |  .|..||... .|  ..|.|..   |. | .     |..| | 
wpdeGsevyhiyevhlvsehiwcddylvrsfylknlqtsetrtvtqfhflswpeegvPasaksllefrrkvnksyrG.rscpivvhcs

PTPc_DSPc_SM00012 289-389 1.1e-31 104.5 In-house 2-105 (105) alignment
Range on Protein: 289-389
Range on HMM: 2-105/105.0
VRQFHFTVWPDKGVPQYATAVLAFRRKVRALNPRDA--GPVIVHCSVGVERTGAYIVIDAMLEQAKKS-RTVDIRNYLIAIRKHRPHMVQTKEQYSFIHS
|...|.| |||.|||......| . |.|.  .   .  .||.|||| || ||| ....| .|.| .|. ..||| ... ..||.||.||||.|||.|.. 
vkhyhytgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqylflyr

AVLE
|.||
alle

subfamily_ptpA1_pd Subfamily ptpA1 155-349 1.7e-31 104.4 In-house 44-254 (418) alignment
Range on Protein: 155-349
Range on HMM: 44-254/418.0
ANKNKNKNRYANIVAYDHSRVVLERVNGDEDLDYINASFIHGydGTPRSFIASQGPLPPAFEGFWRMVWEQNSQSIVMLTNLVGLNKTKCHKYWPDKTET
 ..| .||||.||.  .|.|| |....  |  ||||| .| |    |. ||..||||| .   |||||||.  . ||||.      . || .|||..   
kkhntsknrytnilpvnhtrvqlkkiqdkegsdyinanyidg..aypkqfictqgplpntiadfwrmvwenrcriivmlsresencrikcdrywpeqigg

yGGVTVTLHQSEVFAGYE--NCTFILSKEK-----------RSGSRIVRQFHFTVWPDKGVPQYATAVLAF-----RRKVRALNPRD-AGPVIVHCSVGV
   ...     |||  |       |   |.              .| . |...  |||. .|...  .  .      |. . .   |   |.||||| ||
.eqfsiygngnevfgtysvelveviqdpereiitrnirltfegetrditqyqyegwpdhnipdhtqpfrqllhsitnrqnqiipssdrnvpiivhcsagv

ERTGAYIVIDAMLE
 |||..     |..
grtgtfctavimmk

subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 440-622 3.9e-31 103.0 In-house 10-204 (270) alignment
Range on Protein: 440-622
Range on HMM: 10-204/270.0
EEKSVGEKPQNLHKNRFSDIIALNSCRVMLHKEHADEESDYINAVFLH-AHRGRNAFIATQHPLLETVEDFWRMVTDYDIGTIVMLNNLHDQVAPESSEY
.|... |  .. . ||. ||.     ||.|.... |... |||| ... ..  ....||.. ||  |...||||. .    .|||. .|...   . . |
sesdlpeaargkklnRyadiLPsPatRvrleeleedsataYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkgrkkCerY

WPDHGAT----KYGHIGISVLSKQKKGDVICVKPKVTRKKKTHEVRHLHHVSWTDKCIPKVSR------SVLDLLDEVQTSQQQCGNV-PVLVQC
|| .  .    ..|.| . .||..|.   |  . ....| ..... | ....| |. .|. .       ..| .| .|. |...  .  |.|| |
WpaepkekvkledgkikvlalseekeegyiltrlrleekgeerrlvHfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkaePllvHc

subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 424-623 1.7e-30 100.9 In-house 10-207 (283) alignment
Range on Protein: 424-623
Range on HMM: 10-207/283.0
LEFQRLNSVTsreIPVEEKSVGEKPQNLHKNRFSDIIALNSCRVMLHKEHAdeesDYINAVFLH---AHRGRNAFIATQHPLLETVEDFWRMVTDYDIGT
| ...|. ..   .|  .  .    .| .|||. .|.. .  || |. |      |||||||.     ..  . .|..| || .|| |||.|| | .| .
lfrevlkrls...vpdldadiasadenkrknrnqeivpadqwrvelksesr....dyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfdekita

IVMLNNLHDQVAPESSEYWPDHGATKYGHIGISVLSKQKKGDVICVKPKVTRK---KKTHEVRHLHHVSWTDkCIPKVSRSVLDLLDEVQTSQQQCGNVP
|||| .| ..   . | ||| .|. .||   ...     .   |  .  .  .   |.|  . |   . |.. . ..     |  .. |.. |..  . |
ivmltklqedlrikCsqyWPkrGsedyGeftvtlrkettsnsfiikelllrvnssakstlllahyqvidWle.ygeqaiinslvkfnkvislqteskkgP

VLVQCR
..| | 
ivvhCs

subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 157-399 2.6e-30 100.5 In-house 42-279 (288) alignment
Range on Protein: 157-399
Range on HMM: 42-279/288.0
KNKNKNRYANIVAYDHSRVVLErvngdEDLDYINASFIHGYDGTPRSFIASQGPLPPAFEGFWRMVWEQNSQSIVMLTNLVGLNKTKCHKYWPDKTETY-
.|  ..|| |.   | .|| |.     .| |.  |. .      .| .| .| ||  . | .|.|. |.. . ||||..|. . | |  .|.| |     
anptrdryenlprcditrvkls.....ddpdfyiaanvvssakykrrlicaqaPlngtieelWkmllesdveyivmlcellekGkeksaeyfPsklGeka

--G-GVTVTLHQSEVFAGYENCTFILSKEKRSGSRIVRQFHFTVWPDKGVPQYATAVLAFRRKVRALNprdaGPVIVHCSVGVERTGAYIVIDAMLEQAK
  |   ||. .. .      . . .  ...   . ||.. |.  |.|.|||.   . | .   ...|.     |..||.| || |||. |.|  .||...
rigrlctvvkkkradidklvkvsllriskegeekvivkilhlleWdddgvPenylsplrllevlkslq....kPivvhssaGvGrtgtlililialeslr

KSRTVDIRNYLIAIRKHRPHMVQTKEQYSFIHSAVLEALTCGNTEIQ
 .  . ||. |   |..| . .||. || ..|  ||| |     . .
lddflgirsllaklreerfkaiqtemqylyvhrcvleelllkkykvl

subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 156-397 7.7e-30 98.7 In-house 41-282 (312) alignment
Range on Protein: 156-397
Range on HMM: 41-282/312.0
NKNKNKNRYANIVAYDHSRVVLervNGDEDLdYINASFIHGYdGTPRSFIASQGPLPPAFEGFWRMVWEQNSQSIVMLTNLVGLNKTKCHKYWPDKTety
 | |. ||| ||  .|  |  |    |||.. || | |..     |  |...||||  .   ||...    | ||..|. .|     || ||  |     
lkfkdlnrypniqcwdrgrftl...agdenf.yihanfvkic.tkperfvctqgplentcthfwqlalslgstsiillcgfvedgsekcakyisdiv...

GGvtVTLHQSEVFAgyENCTFIL----SKEKRS-----------GS-RIVRQFHFTVWPDKGVPQYATAVLafrRKVRALNpRDAGPVIVHCSVGVERTG
|   | | .  |..  | || |     ||.| .           |    . .. .. |||.|.|.   . |   | . |.. .|  ||| ||| || |||
gf..vdledhrvyt..eycteieiggkskdkithrvlkvvvkatgqesklnhyqwaswpdhgmpdscdtal...rllsavk.kdkkpviahcsagvgrtg

AYIVIDAMLEQAKKSRTVDIRNYLIAIRKHRPHMVQTKEQYSFIHSAVLEALTCGNTE
. ..|..|.   .. |  .... .. .|| |   |..  || .   .||| | .    
tlaliesmiaalrhprkqnvkdsfvllrkdrarsvrvfpqyvyalrcvleflyskgly

subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 150-315 2.7e-29 97.0 In-house 27-192 (297) alignment
Range on Protein: 150-315
Range on HMM: 27-192/297.0
AARKPANknKNKNRYANIVAYDHSRVVLERVNGDEdlDYINASFIHGY-DGTPRSFIASQGPLPPAFEGFWRMVWEQNSQSIVMLTNLVGLNKTKCHKYW
.|....     |||| .|.|.| .|| | ||  ..  ||||| ..    . ..  .| .||||  . . ||..|.||. . |||...|    . ||  ||
sakrnss..lrknryrdilatddtrvkllrviter..dyinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmvaklqedGrdkcapyw

PDKTE--TYGGVTVTLHQSEVFAGYENCTFI-LSKEKRSGSRIVRQFHFTVWPDKGVPQYATAVLAFRRK
|.  .     |  |  . |..   ...  .  |    || || ||   |  |||.|||     .  |. .
psvvqerlkagdvvveflsstsdefdrviltelqliyrsesrvvrhvqflswpdhGvpsdledlvrfqaq

subfamily_CG7180_pd Subfamily CG7180 420-623 4e-29 96.2 In-house 13-231 (296) alignment
Range on Protein: 420-623
Range on HMM: 13-231/296.0
TGYALEFQRLNSVTSReIPVEEKSVGEKPQNLHKNRFSDIIALNSCRVMLHKEHADEESDYINAVFLHAHRGRNAFIATQHPLLETVEDFWRMVTDYDIG
  . .|.. .  .|.| .  ..   | . .|. |||  ...  .  ||.|.| . .|.|||||||.  ..   ...| |. |  |||..|||.| | .| 
rkfrveyklelkltpr.leigdCagglrkenreknrdvkvvPyDynRvvLekldGeeksdYinavyvdsflkkkeyivteapkketvdefWrlvydeeis

TIVMLNNLHDQVApESSEYWPDHGATKYGHIGISVLSKQKKGDVICVKPKVTRK------------KKTHEVRHLHHVSWTD-KCIPKVSRSVLDLLDEV
..|.| .  |.      .||| .. ..||.| . ......  ..   . |.|.|             .|  |....   |   . .| .. ....|.  |
avvvLtktfdfak.mypsywpnkskeqygeifveiveekqyanlkirtfkltkkivalteqekqvkaetRivklfqlteWeledkvPlstnalielrrrv

QTSQQQC----GNVPVLVQCR
.. ...      . ||.| . 
rlwrekvdedpeegPvvvvss

subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 156-391 5.7e-29 96.0 In-house 33-270 (285) alignment
Range on Protein: 156-391
Range on HMM: 33-270/285.0
NKNKNKNRYANIVAYDHSRVVLErvngDEDLDYINASFIHGYDGTPRSFIASQGPLPPAFEGFWRMVWEQNSQSIVMLTNLVGLNKTKCHKYWPDKTE--
. | . ||||.. . . .||||.    . | ||| ||...       ..|..||||| ..  ||.|.....   ..||  |.     ||  |.|.|    
eanpdlnryadvrcieetrvvlk....nhdrdyihaswmrmpgkdqstyittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekcalyypeklgev

-TYGGVTVT--LHQSEVFAG--YENCTFILSKEKRSGSRIVRQFHFTVWPDKGVPQYATAVLAFRRKVRALNPRDAgPVIVHCSVGVERTGAYIVIDAML
  .|   .|    . |  ||  ... | | ...  |    . . .   |||.  |. |  .. . . |. .||..  |. |||| || || ... ||   
vkfgkyeitlteckeeaiagtilnaltvintedasseplymnhvqvpwwpdqlapedarpmielykwvkkvnpkek.picvhcsagvgrtatfvgidyat

EQAKKSRTVDIRNYLIAIRKHRPHMVQTKEQYSFIHSAVLEAL
 .  .   ... . .  .|  | . ||.. |. |..  ..| .
irimenpniemldivremramrfqavqshmqflflyvvlmeyf

subfamily_PTPN1_pd Subfamily PTPN1 442-622 8.7e-28 91.8 In-house 24-208 (290) alignment
Range on Protein: 442-622
Range on HMM: 24-208/290.0
KSVGEKPQNLHKNRFSDIIALNSCRVMLHKEHAdeesDYINAVFLHAHRGRNAFIATQHPLLETVEDFWRMVTDYDIGTIVMLNNLHDQVAPESSEYWPD
 .. ..|.|  .||. |.   . .|..|....     ||||| ...... .  .| || || .||. ||.|| . .  ..||||.. ..      .||| 
treaklpenrnlnryrdvspydhsrikleradn....dyinaslveleeakrsyiltqGPlpntvdhfWqmvWeqkskavvmlnkvvekeqikcaqywPq

HG---ATKYG--HIGISVLSKQKKGDVICVKPKVTR--KKKTHEVRHLHHVSWTDKCIPKVSRSVLDLLDEVQTSQQQCGNV-PVLVQC
.    . ..   .. . ..|...|   .  . ...    ..|.|. | |...|.|  .|.   . |..| .|. |     .| |... |
geeekellledtklkvkliseerksyytvrllelenlktqetreilhfhyttwpdfgvpespaaflkflfkvresGslssdvGpavihc

subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 447-623 5.8e-27 89.2 In-house 45-220 (439) alignment
Range on Protein: 447-623
Range on HMM: 45-220/439.0
KPQNLHKNRFSDIIALNSCRVMLHKEHADEESDYINAVFLHAHRGRNAFIATQHPLLETVEDFWRMVTDYDIGTIVMLNNLHDQVApesseYWPDHGATK
.  .  |||. |. |..  ||.|..      | |||| ... .   . .|||| |  ||..||||.| .    ||||| || .        |||  . . 
qeydqtknrykdvgafdhtrvtlqeipgvphshyinanyikGyyddklyiatqgpkkettddfwrlviekktvtivmltnlvesyk.....ywpsdaevc

YGHIGISVLSKQKKGDVICVKPKVT----RKKKTHEVRHLHHVSWTDKCIPKVSRSVLDLLDEVQTSQQQCGNVPVLVQCR
|| | . |  . .  . .    ||     . .| . | ..|...| || .|  .  |||.|  .......    ||.|.| 
ygdiavrvdrnielpnyvirgfkvfnerdttekertvlqfhyiawpdknvpaqashvldflrainsandkeeygpvvvhcs

subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 158-409 6.4e-27 89.1 In-house 50-298 (301) alignment
Range on Protein: 158-409
Range on HMM: 50-298/301.0
NKNKNRYANIvAYDHSRVVLERVNGDEdlDYINASFIHGYdGTPRSFIASQGPLPPAFEGFWRMVWEQNSQSIVMLTNLVGLNKTKCHKYWPDKTET---
.|.|.|| ..   . |  |   |.|      | | .|    | |. |||.||||. . | || |.   . . ||||.. |  ...||..| | |..    
pkdkhryptv.PckPstavevivdGkr..vPihanwipts.GhphrfiatqgPlkntsedfwamlvqydvekivmlgqkvekleekceeylpvkisekld

YGGVTVTLHQSEVFAGYENCTFILS---KEKRSGSRIVRQFHFTVWPDKGVPQYATAVLAFRRKVRalnpRDAGPVIVHCSVGVERTGAYIVIDAMLEQA
 |  .......|.    .     |      ..  .| |  . .. |.|.|||.  . .  .   |.    .   |..|||| |. |. |.|  . .  . 
igrfkikiknkelilnkkiskrtlevedstgkfatrtvthyqysewtdrgvPkshaelfdlmelvk....ksekPivvhcsaGiGrsvafigteylarev

KKSRTVDIRNYLIAIRKHRPHMVQTKEQYSFIHSAVLEALTCgNTEIQSEKYNQAMQK
.  .|... . |  .|.|| . |||..|  ..    .  |   . ...   |.. .. 
eadptieltealkhlrehrwngvqtnsqlywmtlGtvyrlik.eygfdmkiyeeqlam

subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 440-622 1.3e-26 88.0 In-house 30-233 (301) alignment
Range on Protein: 440-622
Range on HMM: 30-233/301.0
EEKSVGEKPQNLHKNRFSDIIALNSCRVMLHKEHA--DEESDYINAVFLHAHRGRNAFIATQHPLLETVEDFWRMVTDYDIGTIVMLNNLHDQVAPESSE
.. .|| . .| . ||| .|  ..  |..|.....    . .|||| .... . ...|||.| |. .|. ||||.. ..   .|||. ||...   .. .
ksctvglseenkalnrfknitvyddnriilkpkpnldlcqreyinasyidgysekkkfiaaqgpmkktlvdfWrliwqekpvsivmvtnlkegtkskceq

YWPDHGATKYGHIGISVLSKQKK--G-----------------DVICVKPKVTRKKKTHEVRHLHHVSWTDKCIPKVSRSVLDLLDEVQTSQQQCGNVPV
|||.  |...    ..|. ....                      |  | ||...|....|  |. ..| .  . .  | ||  .|.|   ||. |  ||
ywpnseaeseefgpftvtlvneqvyPdfvirqlnvkiqdgsnngyierkfkvksdksswdvlqlqvtdWpqdGvvreprtvLqviddvihrqqkigggpv

LVQC
.| |
vVHC

subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 438-622 1.4e-26 87.8 In-house 33-176 (392) alignment
Range on Protein: 438-622
Range on HMM: 33-176/392.0
PVEEKSVGEKPQNLHKNRFSDIIALNSCRVMLHKEHADEESDYINAVFLHAHRGRNAFIATQHPLLETVEDFWRMVTDYDIGTIVMLNNLHDQVapesse
.. ...|..|. ||.|||. .|. ..| ||.|       .|||.|| ....    .|.||.| |   ...|||||| . .. ||.|...|..        
diypqtvaqkeinlkknryknilpydsarvkleviddipdsdylnasyipsfdnekayiasqgpnaaslddfwrmvfqenvttiamvtklkegd......

ywpdhgatkyghigisvlskqkkgdvicvkpkvtRKKKTHEVRHLHHVSWTDKCIPKVSRSVLDLLDEVQTSQQQCGNvPVLVQC
                                  . .... |   | . | || .|| . |.| .. ||..   |    |....|
..................................kgddartvaqfhftewPdkdvpkhtssllkfikevkadfGqyth.pliihc

subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 405-622 2.3e-26 87.1 In-house 12-223 (290) alignment
Range on Protein: 405-622
Range on HMM: 12-223/290.0
QAMQKLASVNGKFPMTGYALEFqrLNSVTSR-EIPVEEKSVGEKPQNLHKNRFSDIIALNSCRVMLHKehaDEESDYINAVFLHAHrgRNAFIATQHPLL
.|..|.||   |  . ..| |.  |. .         |... .|  ...|||. |..  .  ||.|.      . ||. | ...    .  || || .| 
eafekfasdvvkknvdelakey..leklkpylpvqylerkifdkntefkknrykdvvcndktrvilkd...GydGdyvhanyvkGl..kamfiltqGalk

ETVEDFWRMVTDYDIGTIVMLNNLHDQVAPESSEYWPDHG--ATKYGHIGISVLSKQKKGDVICVKPK-VTRK--KKTHEVRHLHHVSWTDKCIPKVSRS
.|| |.|||| . .. .|||| .| ..  .  ..|.|..   .  .|.| .    ...| . |  |   |  |   | | ..||. .|| ||.... . .
dtvidiwrmvlqekvaaivmlceliedGkakceqyypekeGevltfGeitvlcseeddkdaniikktlsvrdkdsGkehklkhlkikswpdksvalstla

VLDLLDEVQTSqqqCGnvPVLVQC
.| .|  ...     |  || | |
llrtlrilrka...sG..pvvvhc

subfamily_PTPN14_pd Subfamily PTPN14 441-612 2.9e-26 87.2 In-house 40-218 (300) alignment
Range on Protein: 441-612
Range on HMM: 40-218/300.0
EKSVGEKPQNLHKNRFSDIIALNSCRVMLHKEHADeESDYINAVFLHAHRG--RNAFIATQHPLLETVEDFWRMVTDYDIGTIVMLNNLHDQVAPESSEY
. |... |.| .|||| |..  . .|| |   . . ...||||  ...  |  .  .|..| ||  ||.|||.|| . ..  |||| . ...    | .|
llstaklpenaeknrfkdvlPyednrvelsptken.stgyinassikvsvggkersyivaqgPleltvqdfWqmvWeqgvqlivmlteeeedgkeksfky

WPDH----GATKYGHIGISVLSKQKKGDVICVKPKV--TRKKKTHEVRHLHHVSWTDKCIPKVSRSVLDLLDEVQTSQQQ
.|..       ..|.  ..   ... . ||  . |.     |.  .| || .. |.|. .|.  .. |. |.|||  ...
fPkleskkktvefgkfkvttkfsedsdsvittglklkhlpskeertvwhlqytDWpdhgvPeDvkgflsyLeevqsvrrk

subfamily_PTPN13_pd Subfamily PTPN13 425-622 9e-26 85.7 In-house 16-209 (273) alignment
Range on Protein: 425-622
Range on HMM: 16-209/273.0
EFQRLNSVTsreiPVEEKSVGEKPQNLHKNRFSDIIALNSCRVMLHKEHAdeesdYINAVFLHAHRGRNAF--IATQHPLLETVEDFWRMVTDYDIGTIV
||. |. .     |... .||.| .| .|||. ...  .  || | .| .     |||| ..... | . .  ||.| || |||.|||.|| . .   |.
efkelrelk....pldtcevgkkkenkdknryrnvlPydetrvklgdegg.....yinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweqkaevia

MLNNLHDQVAPESSEYWPDHGATK---YGHIGISVLSKQKKGDVICVKPKV--TRKKKTHEVRHLHHVSWTDKCIPKVSRSVLDLLDEVQTSQQqcGNVP
|. .  ..       |||..   |   .. . ...|  ||. .    . .|  .. ....|| ||. |.| |  .|. . ..| .. ||.. |.   . |
mvtlekekgkvkchrywPesknkklkvsnrlevellkvqkldgfvvralavkdsesgesrevahlnfvkwPdhgvPssaaellqfvaevrrlqt..dagP

VLVQC
..| |
ivvhc

subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 436-598 2.4e-24 80.7 In-house 19-185 (297) alignment
Range on Protein: 436-598
Range on HMM: 19-185/297.0
EIPVEEKSVGEKPQNLHKNRFSDIIALNSCRVMLHKEHadEESDYINAVFLH--AHRGRNAFIATQHPLLETVEDFWRMVTDYDIGTIVMLNNLHDQVAP
|   |. |.  ..  |.|||. ||.| .. || | .     |.||||| ..          .| .| || .||.|||..|.. |...|||. .| ..   
eargesfssakrnsslrknryrdilatddtrvkllrvi..terdyinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmvaklqedGrd

ESSEYWPD--HGATKYGHIGISVLSKQKK--GDVICVKPKVTRKKKTHEVRHLHHVSWTDKCIPKVSRS
    |||.   .  | |.. .  ||.       ||  . ..  ....  |||  ..|| |. .|     
kcapywpsvvqerlkagdvvveflsstsdefdrviltelqliyrsesrvvrhvqflswpdhGvpsdled

0041856 (Phosphotyrosine protein) phosphatases II 450-624 3e-24 81.0 In-house 1-118 (182) alignment
Range on Protein: 450-624
Range on HMM: 1-118/182.0
NLHKNRFSDIIALNSCRvmlhkehadeESDYINAVFLHAHRGRNAFIATQHPLLETVEDFWRMVTDYDIGTIVMLNnlhdqvapeSSEYWPDHGatkygh
||.|||.|||.  .  |           .||||| ..   .  . |||||.|||.||.||.||. ...|.|||.|.         .  |||..       
nldknrysdilpydhsr..........dldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt.........eelywpell......

igisvlskqkkgdvicvkpkvtrkkkTHEVRHLHHVSWTDKCIPKvSRSVLDLLDEVQTsqqqcGNVPVLVQCRY
                          .... ......| | ..|   ...||...||.       . |||| |..
..........................erlgiqylylpwpDhgvpd.ldelldfieevle.....eggpvlVHCsa

0048076 (Phosphotyrosine protein) phosphatases II 276-388 2.2e-23 77.9 In-house 34-140 (145) alignment
Range on Protein: 276-388
Range on HMM: 34-140/145.0
FILSKEKRSGSRIVRQFHFTVWPDKGVPQYATAVLAFRRKVRALNPRDaGPVIVHCSVGVERTGAYIVIDAMLEqakksRTVDIRNYLIAIRKHRPHMVQ
. |. |..  .| . |.... ||| |||. .  .|.| . .... ... |||.|||| || |||...... ||.     . |.. . |  .|..||..|.
lnltselellerlgiqylylpwpDhgvpdllellleflefieealkeg.gpvlVHCsaGvgRtgtlvaaylmll.....lgvsleealelvrsqrpgavp

TKEQYSFIHSAVL
. .|. |.. ..|
npgqlrflyefel

subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 446-622 3.4e-23 76.9 In-house 34-217 (287) alignment
Range on Protein: 446-622
Range on HMM: 34-217/287.0
EKPQNLHKNRFSDIIALNSCRVMLHKEhADEESDYINAVFLHAHRGRNAFIATQHPLLETVEDFWRMVTDYDIGTIVMLNNLHDQVAPESSEYWPD-HGA
|.  . .|||..|.. ..  ||.| .| ..  |||||| .. ...  .||||.| |.  || ||||.| .    .....    ..   .  .|||. .  
eelaavkknryadvlPiddtrvllsae.gelGsdyinanyvasytddeafiaaqgPiaatvrdfwravletrsasvitmtreveearlkcykywPerevP

TKYGHIGISVLSKQKKGDVICVKPKVTRKKKTHE---VRHLHHVSWTDKCIPKV----SRSVLDLLDEVQTSQQQCGNVPVLVQC
 . |   . .|....|    .|.     . .|.|   |. |. .|| || ..       | |||  . .. ...  .  |..| .
mrvGGysvvlldydikePeygvralrlidletrearvvkqldllswPdkvlaPtavglirfvldvkqhielardasevGPlvvhd

subfamily_egg_pd Subfamily egg 156-388 4.5e-23 76.4 In-house 38-267 (307) alignment
Range on Protein: 156-388
Range on HMM: 38-267/307.0
NKNKNKNRYANIVAYDHSRVVLERVNGDEDLDYINASFIHGYDgTPRSFIASQGPLPPAFEGFWRMVWEQNSQSIVMLTNLVGLnkTKCHKYWPDKtETY
. |..| |   .   | ||| ||  .|    |.| |  ..|       || .| ||  . . |||||.... | |||||  .     .|. |||   |. 
dnnlekarskrvhckdssrvklelrrGqylddfihanrvkGkp.llnefilaqaplkntvddfwrmvfqeevqyivmltsrkes..erceyywpka.esd

GGVT--VTLHqSEVFAGYE--NCTFILSKEKRSGSRiVRQFHFTVWpdKGVPQYATAVLAFRRKVRALNpRDAGPVIVHCSVGVERTGAYIVIDAMLEQA
  ||   .|.  | .  ..  .  | ..| |  |.    . .   |  .|  .... |    | .| |  . . ||.|..  || .... . |.  | . 
slvtvpGslr.ienlkvdskadplfrvtklklvGgd.deerflehw..qgdvnnssdvysplrvlrklr.nlskpvvvqdilGvskaatlvaieiallsl

KKSRT--VDIRNYLIAIRKHRPHMVQTKEQYSFIHSAVL
 .  .    ...    .|..|.  |..  .| |..  ||
lrGpitkslvlravvflrlrrrlsvesvllylfvyrlvl

subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 449-622 5.6e-23 76.4 In-house 2-179 (237) alignment
Range on Protein: 449-622
Range on HMM: 2-179/237.0
QNLHKNRFSDIIALNSCRVMLHKEHADeeSDYINAVFLHAHRGR-NAFIATQHPLLETVEDFWRMVTDYDIGTIVMLNNLHDQVAPESSEYWPDHG-ATK
.|  |||...|.| . .||.|.   ..  |||||| .|.   |  . .||.| ||  . .|||.|| .     ||||  | ..      .|||.    . 
enkiknrygnivaydhsrvvlkgagsg..sdyinatylkgfdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywpstdqpaa

YGHIGISVLSKQKKGDVICVKPKVTRKKKTHEVRHLH---HVSWTDKCIPKVSRSVLDLLDEVQT-SQQQCGNVPVLVQC
|| . .|.  |..  |       .... . .||| .|     || |. .|. . ..| .  ..   |.      | .. |
ygvltvslkkkeefsdytvrslllskrltlkevrlihqyqftswpdrgvpqqtaallrfrkniinrsphvsesgpwiihc

subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 447-622 8.5e-23 75.8 In-house 5-181 (239) alignment
Range on Protein: 447-622
Range on HMM: 5-181/239.0
KPQNLHKNRFSDIIALNSCRVMLHKEHADEESDYINAVFLHAHRGR-NAFIATQHPLLETVEDFWRMVTDYDIGTIVMLNNLHDQVAPESSEYWPDHgAT
|  |  |||...|.. .  ||.| |   |  |||||| .|. . |  .|.||||  .  .  |||||. .     ||||  | .    .  .||||  ..
krvnkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpds.ts

KYGHIGISVLSKQKKGDVICVKPKVTRKKKTHE--VRHLHHVSWTDKCIPKVSRSVLDLLDEVqTSQQQCGNVPVLVQC
||  . ...   .   | |     ...  .| |  | . |   | || .|. . .|| |  .. | .   |  | ...|
kycnlrvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrki.tkdslpgarpwvihc

subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 447-622 9.3e-23 75.6 In-house 4-180 (239) alignment
Range on Protein: 447-622
Range on HMM: 4-180/239.0
KPQNLHKNRFSDIIALNSCRVMLHKEHADEESDYINAVFLHAHRGR-NAFIATQHPLLETVEDFWRMVTDYDIGTIVMLNNLHDQVAPESSEYWPDHgAT
|  |  |||...|.. .  ||.| |   |  |||||| .|. . |  .|.||||  .  .  |||||. .     ||||  | .    .  .||||  ..
krvnkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpds.ts

KYGHIGISVLSKQKKGDVICVKPKVTRKKKTHE--VRHLHHVSWTDKCIPKVSRSVLDLLDEVqTSQQQCGNVPVLVQC
||  . ...   .   | |     ...  .| |  | . |   | || .|. . .|| |  .. | .   |  | ...|
kycnlrvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrki.tkdslpgarpwvihc

0048179 (Phosphotyrosine protein) phosphatases II 281-385 1.3e-22 75.5 In-house 41-139 (144) alignment
Range on Protein: 281-385
Range on HMM: 41-139/144.0
EKRSGSRIVRQFHFTVWPDKGVPQYATAVLAFRRKVRALNPRDaGPVIVHCSVGVERTGAYIVIDAMLeqakkSRTVDIRNYLIAIRKHRPHMVQTKEQY
|. .  | . |.... ||| |||.... .|.| . .... ... |||.|||| || |||...... |.      . ... . |  .|..||..|.. .|.
epefleregiqylhlpwpDhgvpdllellleflefieealeeg.gpvlVHCsaGvgRtgtlvaaylmk.....klglsleealalvrsrrpgavpnpgql

SFIHS
 |.. 
rfLle

subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 449-623 2.6e-22 74.2 In-house 42-212 (288) alignment
Range on Protein: 449-623
Range on HMM: 42-212/288.0
QNLHKNRFSDIIALNSCRVMLHkehaDEESDYINAVFLHAHRGRNAFIATQHPLLETVEDFWRMVTDYDIGTIVMLNNLHDQVAPESSEYWPDHG--ATK
.|  ..|. ..   . .|| |.    |.   ||.|  . ... .. .| .| ||  |.| .|.|. . |.  ||||..| ..  ..| ||.| .   ...
anptrdryenlprcditrvkls....ddpdfyiaanvvssakykrrlicaqaPlngtieelWkmllesdveyivmlcellekGkeksaeyfPsklGekar

YGHIGISVLSKQKKGDVICV--KPKVTRKKKTHE-VRHLHHVSWTDKCIPKVSRSVLDLLDEVQTSQQqcgnvPVLVQCR
.|..   |  |..  | . .    ..... ...  |..||   | |...|.   | | ||. ... |.     |..|...
igrlctvvkkkradidklvkvsllriskegeekvivkilhlleWdddgvPenylsplrllevlkslqk.....Pivvhss

0049772 (Phosphotyrosine protein) phosphatases II 444-623 4.2e-22 74.7 In-house 40-220 (314) alignment
Range on Protein: 444-623
Range on HMM: 40-220/314.0
VGEKPQNLHKNRFSDIIALNsCRVMLHKEHADEeSDYINAVFLHAHrgrNAFIATQHPLLETVEDF----------WRMV--TDYDIGTIVM--------
|. .. | .|||. ||.  . .||.|.... .  |||||| ... .   ..|||||.|| .||.||          ||||   |... .|||        
vadlflnrdknryldilpad.nrvilpglpvsg.sdyinasyvdgf...lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivmsrdevlad

-------------LNNLHDQVapesseywpdhgaT---------KYghigisvlskqkkgdvicvkpKVT--RKKKTHEVRHLHHVSWTDKCIPkVSRSV
             |..|  .                                               ...  ... .... ..... ..| . |  .. .
elsrLdaAlgKtpllildgng.............neptaadlellk.....................eelydpelferlgikylripvpDgsap.lledf

LDLLDEVQTSqqqCGNVPVLVQCR
...|. ...      . |||| |.
deflefieea...dkggpvlvHCk

subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 401-565 5.3e-22 72.8 In-house 8-167 (310) alignment
Range on Protein: 401-565
Range on HMM: 8-167/310.0
EKYNQAMQKLASVNGKFPMTGYALEFQRLNSVTSREIPVEEksvgeKPQNLHKNRFSDIIALNSCRVMLHKEHADeESDYINAVFLHAHRGRNAFIATQH
 || .|....     |. . | . ....|..     .  |        ...||||.||.. |...|| |. ...    ||| | ....   |..|| .| 
lkylkalenfiiateklgieglvkqyrkldakqdssltyea.....ykkymhknrysdvvcldtsrvklkidksr.yedyihanyvktnylrstficsqg

PLLETVEDFWRMVTDYDIGTIVMLNNLHDQVAPESSEYWPDHGATK-YGHIGISVLSKQKKGDVIC
||  |. |||||. .    .|..| .  ..  | .  |||  | |. || | .. ||.  .   ||
plqhtiidfwrmifqeraesilllckvgeegrpkcvgywpslgvtetygcirvtnlsesseefeic

0043147 (Phosphotyrosine protein) phosphatases II 475-623 6.7e-22 73.4 In-house 2-108 (172) alignment
Range on Protein: 475-623
Range on HMM: 2-108/172.0
DEESDYINAVFLHAHRGRNAFIATQHPLLETVEDFWRMVTDYDIGTIVMLNNLhdqvapesseywpdhgatkyghigisvlskqkkgdvicvkpKVTRKK
|| |||||| .|. ..  . ||||| || .|..|||||. ...|..||.|..|                                          .....
degsdyinasyldlyyipdrfiatqgplrntladfwrmlkelgithivnltel.........................................lydpel

KTHEVRHLHHVSWTDKCIPkVSRSVLDLLDEVQTSQQQCGNVPVLVQCR
 .... ......| | . |  .. .|..|. ... .... . |||| |.
lerlgiqylylpwpDhgvp.llellleflefidellalspggpvlVHCs

subfamily_ptpA1_pd Subfamily ptpA1 439-622 1.2e-21 72.0 In-house 36-236 (418) alignment
Range on Protein: 439-622
Range on HMM: 36-236/418.0
VEEKSVGEKPQNLHKNRFSDIIALNSCRVMLHKEHADEESDYINAVFLHAHRGRnAFIATQHPLLETVEDFWRMVTDYDIGTIVMLNNLHDQVAPESSEY
  | | |.| .|  |||...|. .|  || |.| .  | |||||| ..     .  ||.|| || .|. |||||| .     ||||.   ...  .   |
psetsegdkkhntsknrytnilpvnhtrvqlkkiqdkegsdyinanyidgaypk.qfictqgplpntiadfwrmvwenrcriivmlsresencrikcdry

WPDH-GAT----------KYGHIGISVL--SKQKKGDVICVKPKVTRKKKTHEVRHLHHVSWTDKCIPKVSRSVLDLLDEVQTSQQQC-----GNVPVLV
||.. |             .|   . ..   .. . ..|  . ..| . .|... . ..  | |. ||  .. . .||  .   |.|       |||..|
wpeqiggeqfsiygngnevfgtysvelveviqdpereiitrnirltfegetrditqyqyegwpdhnipdhtqpfrqllhsitnrqnqiipssdrnvpiiv

QC
.|
hc

0036282 (Phosphotyrosine protein) phosphatases II 478-624 2.2e-21 71.8 In-house 2-113 (174) alignment
Range on Protein: 478-624
Range on HMM: 2-113/174.0
SDYINAVFLHAHRGRNAFIATQHPLLetvedFWRMVTDYDIGTIVMLNNLHDQVAPESSEYWPDhgatkyghigisvlskqkkgdvicvkpkvTRKKKTH
|||||| .|. ..  . .||.|.||      ||.|. ...| |.|||....         |||.                             .|.  ..
sdyinaspldlsyitprliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe.............................lredler

EVRHLHHVSWTDKCIPKVSRsVLDLLDEVQTSQQQCGNVPVLVQCRY
.. ..... | | . | .|  .|.....|.. ...... |||| |. 
lgiqylylpwpDhgvpdlsi.llefvkfveealsedpggpvlVHCsa

0051429 (Phosphotyrosine protein) phosphatases II 478-623 5.1e-21 71.0 In-house 4-158 (272) alignment
Range on Protein: 478-623
Range on HMM: 4-158/272.0
SDYINAVFLHAHRG---RNAFIATQHPLLETVEDFWRMvTDYDIGTIVMLNNLHDQVAPESSEYWP------------DHGATKYGHIGISVLSKQKKGD
|.|||| ..    .   .........||  |..||||.  ...| |||.| ... . .   . |||            ..    ||.. . .||.. . |
sgyiNardvggygrvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseellld

VICVKPKVT---RKKKTHEVRHLHHVSWTDKCIPKvsRSVLDLLDEVQTsqqqcgNVPVLVQCR
.|. .  .|     ....||.|||. .| | ..|.   ..|.||.....      . |||| |.
yilrellltlllsagearevmhlhytdwpdhgvpq..eallellellld......ggpvlvHCs

subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 159-277 1.1e-20 68.6 In-house 48-178 (350) alignment
Range on Protein: 159-277
Range on HMM: 48-178/350.0
KNKNRYANIVAYDHSRVVLER--------VNGDEDLDYINASFIHGY----DGTPRS-FIASQGPLPPAFEGFWRMVWEQNSQSIVMLTNLVGLNKTKCH
  |||| ||. |.|||| |..            .  |||||....      .  |   .|| |.||| ... |.... . . . |..||..| ||  ||.
faknrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvkvilsltsdvelnlekcy

KYWPDKteTYGGVTVTLHQ-SEVFAGYENCTFI
.||..   .| ..|| | .  |  .| ....  
rYWqeg..sydditvklaskwenimgindssly

subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 156-388 2.1e-20 67.3 In-house 49-282 (302) alignment
Range on Protein: 156-388
Range on HMM: 49-282/302.0
NKNKNKNRYANIVAYDHSRVVLERvngdEDLDYINASFIHGYDGTpRSFIASQGPLPP---AFEGFWRMVWEQNSQSIVMLTNLVGLNKtKCHKYWPDKT
 || .||.  .. ..|. .| ||     |  .|.||| ..  . | || | .| |      . | |||||.... .|.|.|     |.|   ....| |.
kknlkknqsedvpildsnlvklea....epdsyvnaskvevPelt.rsiilaQlpkvdsedsveeFWrmvfqekivsvvilvgeeelkk.tlselfpkks

ET---YGGVTVTLHQSEVFAGYE-NCTFILSKEKRSGSRIVRQFHFTVWPDKGVPQYATAVLAFRRKVRALNPRDAGPVIVHCSVGVERTGAYIVIDAML
..   || . |   . |   . . . .  .  |  | | ..   ..| |..| ||.  ... .   || |..     ....    |. | || ..  . .
gdykeygkmfvNnrkVekaeeektryviEvlPegcsnsvlanvyvltnWkqkkvpvkyaeliktaakvfakkikadentvivSknGaGRagafltlavav

EQAKKSRTVDIRNYLIAIRKHRPHMVQTKEQYSFIHSAVL
|. .|.  . | . ...||. ||..|.. .|| ... |.|
eklqkgkepnikeivksiRsqRpravdslkQyvslyiall

subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 202-384 4.7e-20 66.6 In-house 5-197 (199) alignment
Range on Protein: 202-384
Range on HMM: 5-197/199.0
RSFIASQGPLPPAFEGFWRMVWEQNSQSIVMLTNLVGLNKTKCHKYWPD---KTETYGGVTVTLHQSEVFAGYENCTFILSKEKR--SGSRIVRQFHFTV
| .||.| ||  ..  ||.||||  |  |||. .    ...    |||     |  || ..|| .   . . |  ...||...      .| . .. || 
rryiatqhplretmadfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqfts

WPDKGVPQYAT---AVLAFRRKVRALNPRDAGPVIVHCSVGVERTGAYIVIDAMLEQAKKSRT--VDIRNYLIAIRKHRPHMVQTKEQYSFIH
| .|  |. |     |.| |   .  .     ||||||| |   || .. .|  .   ..|.|  ||. .    .|. |  .. . ..| ||.
wkekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiy

subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 425-623 4.7e-20 66.7 In-house 11-200 (267) alignment
Range on Protein: 425-623
Range on HMM: 11-200/267.0
EFQRLNSVTSREIPVeEKSVGEKPQnlHKNRFSDIIALNSCRVMLHKEHADeesdYINAVFLHAHRGRNAFIATQHPLLETVEDFWRMVTDYDIGTIVML
||. .. ... .  .  .|..|| |   .||. | .  .  ||.| ..  .    |||| ...... .||||.|| ||  |. ||. ...|... .||.|
efelikkisdtssti.sqsiaeknq..ernrlddnlpyddtrvilrtkeee....yinasyvegyktknafivtqdplkntitdfltvihdqkvpvivll

NNLHdqvAPESSEYWPDH--GATKYGHIGISVLSKQKKG--DVICVKPKVtRKKKTHEVRHLHHVSWTDKCIPKVsrSVLDLLDEVQTSQQQCGNVPVLV
 .       .   .|| .   | ||  . .    ....   ..| .. |. ... .|.|   ..  |  .   |    .  |.  .   | . || |..|
tkvf...tdnirlfwPPkmgqakkyqdltvehslekeendyqiitlelkf.knesahnvtlyyykkwnintnnkp..ylkplfgilaknqlengnrPlvv

QCR
.| 
acs

subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 202-384 5e-20 66.5 In-house 4-196 (198) alignment
Range on Protein: 202-384
Range on HMM: 4-196/198.0
RSFIASQGPLPPAFEGFWRMVWEQNSQSIVMLTNLVGLNKTKCHKYWPD---KTETYGGVTVTLHQSEVFAGYENCTFILSKEKR--SGSRIVRQFHFTV
| .||.| ||  ..  ||.||||  |  |||. .    ...    |||     |  || ..|| .   . . |  ...||...      .| . .. || 
rryiatqhplretladfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqfts

WPDKGVPQYAT---AVLAFRRKVRALNPRDAGPVIVHCSVGVERTGAYIVIDAMLEQAKKSRT--VDIRNYLIAIRKHRPHMVQTKEQYSFIH
| .|  |. |     |.| |   .  .     ||||||| |   || .. .|  .   ..|.|  ||. .    .|. |  .. . ..| ||.
wkekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiy

subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 426-622 4.8e-19 63.5 In-house 22-216 (307) alignment
Range on Protein: 426-622
Range on HMM: 22-216/307.0
FQRLNSVTSREIPVEEKSvgekpQNLHKNRFSDIIALNSCRVMLHKEHAdeESDYINAVFLHAHRGRNAFIATQHPLLETVEDFWRMVTDYDIGTIVMLN
|. |   |   ..||  |      | .|||..|. . . .|.... . .   |||| | .|      . ||..| || .|. .|| |. . .. ...|| 
frvlakktpegvtveafs.....antdknryqdvkcqdkgrivvkfdgl..asdyihanylgiaikpkkficaqgplentqysfwamaiqekvesvimlc

NLHDQVAPESSEYWPDHGATK--YGH----IGISVLSKQK---KGDVICV-KPKVTRKKKTHEVRHLHHVSWTDKCIPKVSRSVLDLLDEVQTSQQqcgn
.. .       .|||     |  .|.    | .. |  .|     |.| | . ||   .|.  ..||    | |. .|..  . ..||. |.  .     
kvielakikceqywpleegqklvfgeapntisvanlgakklapdedlinvttlkvdwaqksrtiqhlqwenwpdrgvpqinltainlleavrydtn....

vPVLVQC
 ||.| |
.pvvvhc

0046846 (Phosphotyrosine protein) phosphatases II 471-623 2.9e-18 61.7 In-house 5-117 (176) alignment
Range on Protein: 471-623
Range on HMM: 5-117/176.0
KEHADEESDYINAVFLHAHRgrnaFIATQHPLLETVEDFWRMVTDYDIGTIVMLNNLHDQVAPESSEYWPDhgATKYGHigisvlskqkkgdvicvkpkv
. . |. .||||| ..  .|    .||||.|| .|..||..|. ...|...|.|.....        |||.   .|.|.                     
llgldldldyinanlilgsr....piatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpe..leklgi.....................

trkkkthevrHLHHVSWTDKCIPKVsRSVLDLLDEVQTSQQQcgNVPVLVQCR
          . .|. | | ..|   . .|.||..... ...  . |||| |.
..........qylhlpwpDhgvpdl.elllellefirealke..ggpvlVHCs

subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 436-608 8.9e-18 58.9 In-house 23-198 (281) alignment
Range on Protein: 436-608
Range on HMM: 23-198/281.0
EIPVEEKSVGEKPQNLHKNRFSDIIALNSCRVMLHK-EHADEESDYINAVFLHAHRGRNAFIATQHPLLETVEDFWRMVTDYDIGTIVMLNNLHDQVAPE
. | .  .| ..| | .|||...| .|.  || |.      . .||| | ....   .  .| || |  ||  |||||. . .  .|||| .. .    .
dppsdlctvfnqpvnnkknrylnipcldisrvqlkvkmpnknstdyihanyirspflkrgyiltqgpkketradfwrmiwqenttaivmlcqfletnrek

SSEYWPD--HGATKYGHIGISVLSKQKKGDVICVKPKVTRKKKTHEVRHLHHVSWTDKCIPKVSRSVLDLLDEVQT
 .||.|   | . .. .. .|      .  ..  . ... . .|. . |     | |  .|. |  .| .| ....
caeyfprnahcclqfdklsvsyedstvnkslvttrlnlsyegetrlithwlwkewpdwqvpessevmlkilrkira

subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 157-408 9.3e-18 59.4 In-house 18-277 (290) alignment
Range on Protein: 157-408
Range on HMM: 18-277/290.0
KNKNKNRYANIVAyDHSRVVLERVNGDEDLDYINASFIHGYDGTprSFIASQGPLPPA-------FEGFWRMVWEQNSQSIVMLTNLVGLNKT----KCH
|.. ..|... ..  ..||||.        ||| |...   .|    .|..| |.           | || |. . .....||| .    ..      | 
khemdqRlevpLv.eatrvvLkgygkrfnddyiHAnrvtcpngl..rliltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCa

KYWPDKTE---TYGGVTVTLHQSEVFAGYENCTFILSKEKRSGSRIvRQFHFTVWPDKGVPQYATAVLAFRRKVRalnpRDAGPVIVHCSVGVERTGAYI
|| |.. .   ...|.||   . |   . |. . ..  ...    .     .  | .  |..    .|.  .||.        ||||||  |. |  |  
kYvpesvgeelkfkgltvkCkskekeddvetRelvvkfddeeeftv.tHsllkgWnklnvqedtktllsliqkvk....asktpvivHcvdGiSrsAala

VIDAMLE-QAKKSRTVDIRNYLIAIRKHRPHMVQTKEQYSFIHSAV-LEALTCGNTEIQSEKYNQAMQ
 |.      |..|  | ... | |.||.| ..........|.  .. | |   ... ...|. ..|..
aiilgyQkiaetsgsvkledvlkalrkqralaitsalelafvdagivllaievldqfaeeetekkaka

subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 435-546 1.3e-17 58.6 In-house 32-157 (350) alignment
Range on Protein: 435-546
Range on HMM: 32-157/350.0
REIPVEEKSVGEKPQNLHKNRFSDIIALNSCRVMLH--------KEHADEESDYINAVFLHAH----RGRNAF--IATQHPLLETVEDFWRMVTDYDIGT
 | | ..  . |  .   |||...|.  .  || |.        |.|. . .||||| .|.      .    |  |||| || .||.||.....  ..  
sespsnDvilseGvelfaknrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvkv

IVMLNNLHDQVAPESSEYWPDHGATK
|..|... ..      .||.. .  .
ilsltsdvelnlekcyrYWqegsydd

subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 214-391 1.4e-17 58.7 In-house 40-221 (255) alignment
Range on Protein: 214-391
Range on HMM: 40-221/255.0
AFEGFWRMVWEQNSQSIVMLTNLVGLNKTKCHKYWP---DKTETYGGVTVTL--HQSEVFAGYENCTFILSKEKRsgSRIVRQFHFTVWPDKGVPQYATA
. . |....  .... .|||...   .. ||..|.|   |.   .  |.||     ..|     . |  |.. |.   . |. .... |..|  |. |  
tvdkfyqtivqtktevvvmlcdfaeegvekcssyfplekdeklkladvnvtttkssadvvlrtleitstlgekkk..thtvkhysykGWieknaPelare

VLAFRRKVRalnprDAGPVIVHCSVGVERTGAYIVIDAM----LEQAKKSRTVDI--RNYLIAIRKHRPHMVQTKEQYSFIHSAVLEAL
.|   . ||     |. .|.|||| |. |. |..... .    . . ... ||..  .. |  .|..|.  ..|  | .|    ||. .
ilnilkvvr.....dsksvvvhCstGiGrsaafvlaelvyqkmirsldttetveldylslleelrskrkraihtPlqlafsilmvldlv

subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 447-611 1.7e-17 58.1 In-house 45-220 (305) alignment
Range on Protein: 447-611
Range on HMM: 45-220/305.0
KPQNLHKNRFSDIIALNSCRVMLHKEHAdeeSDYINAVFLHAHRGRNAFIATQHPLLETVEDFWRMVTDYDIGTIVMLNNLHDQVAPESSEYWPDHG--A
. |. .|||. |.  |.  || |.        .|| | .. .    . || || || .|  ||| |  .  . .| || || .. |   .||.. .    
eaqeagknrykdvgcldnnrvklegpwp...heyihanyvstptnpkrfictqaplektcadfwymclqdkveaifmlcnllekgakkcleyfaskdkdv

TKYGHIGISVLSKQKKGDVIC----VKPKVTR--------KKKTHEVRHLHHVSWTDKCIPKVSRSVLDLLDEVQTSQQ
 ..   |  .  | .    .      | |||.         .|.. | | | . | |. .|    ..|.|| . ..|. 
lefeekgqkisvkfessvtlkfrkdakakvtetvlviegpgekarkvthyhwidwpdrgvpaadlailellekarpskg

subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 489-623 1.8e-17 58.2 In-house 1-143 (199) alignment
Range on Protein: 489-623
Range on HMM: 1-143/199.0
HRGRNAFIATQHPLLETVEDFWRMVTDYDIGTIVMLNNLHDQVAPESSEYWP--DHGATKYGHIGISVLSKQKKGDVI----CVKPKVTRKKKTHEVRHL
|.|.  .||||||| ||. |||.|| .   | |||.|.   .   . . |||  . |..||| . ... .   | |       .  ..|    | |. | 
hkgqrryiatqhplretmadfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishy

HHVSWTDKCIPKVSRSVLDLL--DEVQTSQQQCGNVPVLVQCR
   || .|  |.|.  |  ..   ||    .|  . ||.|.| 
qftswkekttpnvalfvgfvvasrevskkyeqekdapvivhcs

subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 481-622 1.9e-17 58.0 In-house 78-221 (301) alignment
Range on Protein: 481-622
Range on HMM: 78-221/301.0
INAVFLHAHRGRNAFIATQHPLLETVEDFWRMVTDYDIGTIVMLNNLHDQVAPESSEYWPDHGATK--YGHIGISVLSKQK------KGDVICVKpKVTR
| | .. ..   . ||||| || .| |||| |.. ||. .|||| .  ..     .|| | . . |   |   | . .|..      .   . |.   |.
ihanwiptsGhphrfiatqgPlkntsedfwamlvqydvekivmlgqkvekleekceeylpvkisekldigrfkikiknkelilnkkiskrtleve.dstg

KKKTHEVRHLHHVSWTDKCIPKVSRSVLDLLDEVQTSQQqcgnvPVLVQC
| .|. | |  ...|||. .||    . ||.. |. |..     |..|.|
kfatrtvthyqysewtdrgvPkshaelfdlmelvkksek.....Pivvhc

subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 491-623 6.9e-17 56.3 In-house 2-142 (198) alignment
Range on Protein: 491-623
Range on HMM: 2-142/198.0
GRNAFIATQHPLLETVEDFWRMVTDYDIGTIVMLNNLHDQVAPESSEYWP--DHGATKYGHIGISVLSKQKKGDVI----CVKPKVTRKKKTHEVRHLHH
|.  .||||||| ||. |||.|| .   | |||.|.   .   . . |||  . |..||| . ... .   | |       .  ..|    | |. |   
gqrryiatqhplretladfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqf

VSWTDKCIPKVSRSVLDLL--DEVQTSQQQCGNVPVLVQCR
 || .|  |.|.  |  ..   ||    .|  . ||.|.| 
tswkekttpnvalfvgfvvasrevskkyeqekdapvivhcs

subfamily_CG42327_pd Subfamily CG42327 451-609 8.1e-17 55.9 In-house 29-193 (319) alignment
Range on Protein: 451-609
Range on HMM: 29-193/319.0
LHKNRFSDIIALNSCRVMLHKEHADEESDYINAVFLHAHR-GRNAFIATQHPLLETVEDFWRMVTDYDIGTIVMLNNLHDQVAPESSEYWPDH----GAT
  |.|. ... |   ||.|..   |... |..| ..  ..  .| .||.| .| ..  ||||.| .    .|| | .|...     .||.| .    .  
kdksrvinvvPlPetrvvlqrigdddkdeyldasyvrGyddapnsyiaaqvsledsssdfwrtvweqqsrvivqltdlselGikvcaeylPtketldnts

KYGHIGISvLSKQKKGDVICVKPKVTRKKKTHEVRHLHHV--SWTDKCIPKVSRSVLDLLDEVQTS
 ||.| .. | ... .|   .   . .. . .| |.| |    | .  .|   .... .| ||..|
lyGdilvt.lkgrevkdryaistlllkrvdkeesrelthywykwleaevPaeeaaliamllevrss

0049260 (Phosphotyrosine protein) phosphatases II 489-624 2.7e-16 55.1 In-house 5-98 (152) alignment
Range on Protein: 489-624
Range on HMM: 5-98/152.0
HRGRNAFIATQHPLLETVEDFWRMVTDYDIGTIVMLNNLHDQVAPESSEYWpdhgatkyghigisvlskqkkgdvicvkpkvtrkkkthevrHLHHVSWT
..  ..|||||.|. .|..|||||. ...|.|||||..|..   .   .|.                                         . .|. | 
yampfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi.........................................qylhlpwp

DKCIPKVSRSVLDLLDEVQTSqQQCGNVPVLVQCRY
| . |. |  .|.||. ..   ..  . |||| |..
Dhgvpdlsqlllflllfiekl.aldkggpvlVHCsa

subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 450-622 4.7e-16 53.3 In-house 55-228 (305) alignment
Range on Protein: 450-622
Range on HMM: 55-228/305.0
NLHKNRFSDIIALNSCRVMLHKEHadeESDYINAVFLHAHR-GRNAFIATQHPLLETVEDFWRMVTDYDIGTIVMLNNLHDQVAPESSEYWPDHGATK-Y
.  |||..|. . .   | |.|      |||| | .. .     . ||..| || .|...|| || .  .  |||| .  .      ..|||     |  
aitknryqdvpcqdqsavkldkps...psdyihanyvgcpmipekrficaqgpldqtidefwwmviqnkveqivmlcktvelgklkcaqywpaaqgekle

GHIGISV--LSKQK----KGDVICVKPKVTR-KKKTHEVRHLHHVSWTDKCIPKVSRSVLDLLDEVQTSQqqcgnVPVLVQC
 . || |  .|  |      ..     ..|   ...  ||||.   | |. .| .  . |.||  .. |.     ||..|.|
lksgivvenvsgskpmerdaeiqitllnltysgdqkmsvrhlqwtewpdrgvppckltslellsairgsk.....vpivvhc

subfamily_hpo-7_pd Subfamily hpo-7 214-404 1.2e-15 52.1 In-house 46-241 (263) alignment
Range on Protein: 214-404
Range on HMM: 46-241/263.0
AFEGFWRMVWEQNSQSIVMLTNLVGLNKTKCHKYWP---DKTETYGGVTV--TLHQSEVFAGYENCTFILSKeKRSgSRIVRQFHFTVWPDKGVPQYATA
. . |....  .... .|||..    .. || .|.|   |.   .  |.|  |  ||.|    .. . .|.. |.   . |... .. |..|  |. |  
tidkfyqtivqtktevvvmLcDfneegvekcssyfPlekdekqklanvnvcttkvqsdvllktlellstlge.Kkk.thtvkhysykgWiekndpelare

VLAFRRKVRalnprDAGPVIVHCSVGVERTGAYIVIDA----MLEQAKKSRTVDI--RNYLIAIRKHRPHMVQTKEQYSFIHSAVLEALTCGNTEIQSE-
.|   . .|     .  ...|||| |. |. |. |..     |. . ... ||..  .. |  .|..|.  ..|  | .|    ||. .   ... . | 
ilnilkvar.....nskslvvhcstGiGrsaafsvaElvyqkmirsldttstveldylsLleelrssrkraihtPmqLafsilmvLdfvlnnfakgelea

KYN
||.
kyq

subfamily_CG42327_pd Subfamily CG42327 322-386 1.2e-15 52.0 In-house 245-310 (319) alignment
Range on Protein: 322-386
Range on HMM: 245-310/319.0
RDAGPVIVHCSVGVERTGAYIVIDAMLEQAKKS-RTVDIRNYLIAIRKHRPHMVQTKEQYSFIHSA
 . ||..|||| || |||  |  |  ... ..| |.||| . .  .|. | . |.||||| ||.  
esqGPlvvhcsdGvGrtGlviasdiairsleeskrsvdiPqlvssvrrdrasavltkeqyefiykv

subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 314-391 1.6e-15 51.7 In-house 219-295 (297) alignment
Range on Protein: 314-391
Range on HMM: 219-295/297.0
RKVRALNPRDAgPVIVHCSVGVERTGAYIVIDAMLEQAKKSRTVDIRNYLIAIRKHRPHMVQTKEQYSFIHSAVLEAL
  .||  ||.| ...|||| || |.|  .  |..|.. .| |  |..  |  .|. |. .||| ||. ....|||. |
eslraemprna.yllvhcsaGvGrsGvvvlsdvilaklrkkripdvaailsilreqrarlvqtleqfellydavlkkl

subfamily_Sponge-PTP-7_pd Subfamily Sponge-PTP-7 328-394 2e-15 50.9 In-house 2-68 (69) alignment
Range on Protein: 328-394
Range on HMM: 2-68/69.0
IVHCSVGVERTGAYIVIDAMLEQAKKSRTVDIRNYLIAIRKHRPHMVQTKEQYSFIHSAVLEALTCG
.|||| |  |||..| |   . . |  . ||| | .  .|| || ||  . .| ||| |. |||  |
vvhcssgtgrtgtfiaimvemarikseklvdifnnvqymrkcrpmmvmneieyifihdalvealklG

subfamily_egg_pd Subfamily egg 447-595 2.3e-15 51.1 In-house 37-187 (307) alignment
Range on Protein: 447-595
Range on HMM: 37-187/307.0
KPQNLHKNRFSDIIALNSCRVMLHKEHADEESDYINAVFLHAHRGRNAFIATQHPLLETVEDFWRMVTDYDIGTIVMLNNLHDQvaPESSEYWPDHG--A
.  ||.| |   .   .|.|| |. ..     |.| |  .. .   | || .| || .||.||||||   ..  ||||.   .    .   |||     .
sdnnlekarskrvhckdssrvklelrrGqylddfihanrvkGkpllnefilaqaplkntvddfwrmvfqeevqyivmltsrkes..erceyywpkaesds

TK--YGHIGISVLSKQKKGDVICVKPKVTRKKKTHEVRHLHHVSWTDKCIPKV
 .   | . |  |  ..| | .    |.      .| |.| |  .  .   .|
lvtvpGslrienlkvdskadplfrvtklklvGgddeerflehwqgdvnnssdv

subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 113-198 2.8e-15 50.6 In-house 4-87 (440) alignment
Range on Protein: 113-198
Range on HMM: 4-87/440.0
KPIPIALFPEYVAKMHGGIRLETEYKKFNNGQQFPWGAARKPANknKNKNRYANIVAYDHSRVVLERVNGDEDLDYINASFIHGYD
.|| .| | .|| . .     | |.  . .| . |   |  | |  | |||| ||.|||||||.|| |.|  | ||||||.| | .
rpiivadfadyvqnnrrsrafedewsllpsglsqpsdiaslpnn..kvknryrnilaydhsrvmleevkgvpdsdyinasyingie

subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 492-551 3.4e-15 50.3 In-house 235-292 (440) alignment
Range on Protein: 492-551
Range on HMM: 235-292/440.0
RNAFIATQHPLLETVEDFWRMVTDYDIGTIVMLNNLHDQVapeSSEYWPDHG-ATKYGHIG
.||||||| ||  || ||||.| || | ||.|||.| |.     | |||    .  .| . 
knafiatqmpldstvldfwrlvhdyristiimlnqlndkt...csiywpvntrsvtfgpft

subfamily_Sponge-PTP7_pd Subfamily Sponge-PTP7 328-394 3.9e-15 50.0 In-house 1-67 (69) alignment
Range on Protein: 328-394
Range on HMM: 1-67/69.0
IVHCSVGVERTGAYIVIDAMLEQAKKSRTVDIRNYLIAIRKHRPHMVQTKEQYSFIHSAVLEALTCG
.|||| |  |||..| |   . . |  . ||| | .  .|| || ||  ...| ||| |. |||  |
vvhcssGtGrtGtfiaimvemarikseklvdifnnvqymrkcrpmmvmneneymfihdalvealklG

subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 214-391 5.2e-15 49.7 In-house 103-288 (302) alignment
Range on Protein: 214-391
Range on HMM: 103-288/302.0
AFEGFWRMVWEQNSQSIVMLTNLVGLNKTKCHKYWPDKTE---TYGGVTVT---LHQ-SEVFAGYENC-----TFILSKEKRSGSRIVRQFHFTVWPDKG
. | .| .. . |   .| |...|  .. || .|. || .   ..|  ||.   ...  | |.  ..       .  .| |.   . |  ..|. |||.|
tlekhwalieqynvaivvqlcsfvedeekkcaeyysdkvggelkfgrytvktvsvktdleeftdkksfklytveiknekkkkkvkktvdilafsawpdhG

VPQYATAVLAFRRKVRALNPRdagpVIVHCSVGVERTGAYIVIDAMLEQAKKSRTVDIRNYLIAIRKHRPHMVQTKEQYSFIHSAVLEAL
 |. | . |   .   .        |.||||.|| |||. . |   ..  .| .. |. . .. .|. |   ||...|  ..   |  .|
apkeaytaldilkfcesykkn....vlvhcsaGvGrtGtlvaikyGiqlcskkkvtdllsivlpvrqcryGavqdeqqliylllcvtkgl

subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 152-391 1.2e-14 48.6 In-house 41-279 (303) alignment
Range on Protein: 152-391
Range on HMM: 41-279/303.0
RKPANKNKNKNRYANIVAYDHSRVVLErvngdeDLDYINASFIHgYDgTPRSFIASQGPLPPAFEGFWRMVWEQNSQSIVMLTNLVGLNKTKCHKYWPDK
..   || .|||.....  |||.| |       |  || ||...  | . .  | .| ||. .   ||.|. ||. . ...|      .|   .  .| .
knqfvknmdknrfvdvicldhskvkls......dssyihasyle.ld.sskkailtqlplshtaadfwqmiieqkvkcvlllltdseydklggdsvfprn

TETYG----GVT-VTLHQSEVFAGYENCtfILSKEKRSGSRIVRQFHFTVWPDKGVPQY-----ATAVLAFRRKVRALNprDAGPVIVHCSVGVERTGAY
 .        .    ... |.  |.     .||  . .   ..   |.  || . .|          .   .  .|     |. | .     |. |.|..
qdflkfeersirvgefkrvelgdgwvlk..vlsvsngdyksflhvhhykawphnsipsdgspkfvkqiwqlqsvlrkys..dstptvymslsgcgragtf

IVID-AMLEQAKKSRTVDIRNYLIAIRKHRPHMVQTKEQYSFIHSAVLEAL
 ... | |   ..  ..|. . |  .|. | | ||   |.|.... . | .
alfetahlslhseqasldlvkclenvrngrlhavqnlsqfsvvytllaehv

subfamily_eak_pd Subfamily eak 158-316 2.4e-14 47.5 In-house 52-207 (332) alignment
Range on Protein: 158-316
Range on HMM: 52-207/332.0
NKNKNrYANIVAYDHSRVVLERVNGDeDLDYINASFIHgYDGTPRSFIASQGPLPPAFEGFWRMVWEQNSQSIVMLTNLVGLNKTKCHKYWPDKT---ET
. |.|   .|| ||.  | |     .  | ||||| .  .    | .| .  .       ||.|| ||.| .||.| . | |.  |  ||.||||     
avnrn.vvkivpydrylvrltssqln.rlGyinaslae.fsevGrkyiltGiasedkvfafwqmvleqkspaivqlledvelkleksdkyfpdktreelk

YGGVTVTLHQSEVFAGYENCTFILSKEKRsgSRIVRQFHFTVWPDKGVPQYAtAVLAFRRKV
.| . |.  .    . .|   ..|||     .  |  ...  | .  .|.|    ||.|. .
fGildverkefvkrniletrllelskGne..thrvlhykvfGwtettlpkye.dflalrkvm

subfamily_eak_pd Subfamily eak 435-596 3.2e-14 47.1 In-house 37-198 (332) alignment
Range on Protein: 435-596
Range on HMM: 37-198/332.0
REIPVEEKSVGEKPQNLHKNrFSDIIALNSCRVMLHKEHADeESDYINAVFLHAHRGRNAFIATQHPLLETVEDFWRMVTDYDIGTIVMLNNLHDQVAPE
.  ..  .|.... .....|   .|.  .   | |     . .  ||||  .      . .| |  .  . |  ||.|| .    .||.| .  ..   .
dyqrllsisetarleavnrn.vvkivpydrylvrltssqln.rlGyinaslaefsevGrkyiltGiasedkvfafwqmvleqkspaivqlledvelklek

SSEYWPDHG--ATKYGHIGISVLSKQKKGDVICVKPKVTRKKKTHEVRHLHHVSWTDKCIPKVS
|  |.||..    |.|.. .   .  |.. .   . ....  .||.| | .   ||.  .||. 
sdkyfpdktreelkfGildverkefvkrniletrllelskGnethrvlhykvfGwtettlpkye

0051082 (Phosphotyrosine protein) phosphatases II 478-624 1.1e-13 46.6 In-house 3-101 (151) alignment
Range on Protein: 478-624
Range on HMM: 3-101/151.0
SDYINAVFLHAHrgrnaFIATQHPlletVEDFWRMVTDYDIGTIVMLNNLHDQVapESSEYWPDHGatkyghigisvlskqkkgdvicvkpkvtrkkktH
|||||. ..  .     ......|     .||.... ...| |||.|....        ||.|..|                                 .
sdyinfsyvtgg.....lyrsggp....ladflellkelgiktivnlrseeerg..ycpeylpelg.................................i

EVRHLHHVSWTDKCIPKVSRSVLDLLDEVQTsqqqCGNVPVLVQCRY
||.|.. ..|.|  .|    .||..|....     ..| |||| |. 
evlhipildwpdpglplsfdavleflellld....kkngpvlvHCsa

subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 450-622 1.4e-13 45.4 In-house 35-210 (285) alignment
Range on Protein: 450-622
Range on HMM: 35-210/285.0
NLHKNRFSDIIALNSCRVMLhKEHadeESDYINAVFLHA-HRGRNAFIATQHPLLETVEDFWRMVTDYDIGTIVMLNNLHDQVAPESSEYWPDHG--ATK
|   ||..|. ...  ||.| |.|   . ||| | ...   . ....|.|| || ||. |||.|. .  |  ..||  | .    . . |.|..     |
npdlnryadvrcieetrvvl.knh...drdyihaswmrmpgkdqstyittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekcalyypeklgevvk

YGHIGISVLSKQKK---GDVICVKPKVTRKKKTHEVRHLHHV---SWTDKCIPKVSRSVLDLLDEVQTSQQQcgNVPVLVQC
.|.  |..   ...   | ..     .  .  . |  .. ||    | |.  |. .| ...|   |.  . .  . |. |.|
fgkyeitlteckeeaiagtilnaltvintedasseplymnhvqvpwwpdqlapedarpmielykwvkkvnpk..ekpicvhc

0044763 (Phosphotyrosine protein) phosphatases II 464-623 4.5e-13 44.7 In-house 4-118 (178) alignment
Range on Protein: 464-623
Range on HMM: 4-118/178.0
SCRVMLHKEHADEESDYINAVFLHAHrgrnaFIATQHPLletvEDFWRMVTDYDIGTIVMLNNLHDQVAPESSEYWPDHGAtkyghigisvlskqkkgdv
 .|| |..    | ||||||..   .     ......|     .|..... ...|..||.|..      ... .|||.                      
rtrvllsnleglersdyinaseilpg.....lylgslpp....addlellkelgithivnlteelelgflkcdpywpeeag...................

icvkpkvtrkkkthevRHLHHVSWTDKCIPKVSRSVLDLLDEVQTSQQQCGNvPVLVQCR
                 . .|. . | . | ... .|.... ... ....|. |||| |.
................iqylhipipDhgvpdllehflefvefieealdekgg.pvlVHCs

subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 446-547 8e-13 42.6 In-house 92-186 (244) alignment
Range on Protein: 446-547
Range on HMM: 92-186/244.0
EKPQNLHKNRFSDIIALNSCRVMLHKEHAdeESDYINAVFLHAHRGRNAFIATQHPLLETVEDFWRMVTDYDIGTIVMLNNLHdqvapESSEYWPDHGAT
 .|.| .||| .  . ..  || | |        |||| |.        .| ||||| .|  |||.|. .  .  .|.|  .      |  |||||    
fnpnnswknregaglpfdfnrvplskgsm..gntyinasfvgclgrtaeyiltqhpladtsmdfwkmmlerhvnvlvvlgsve.....eedeywpdsepl

KY
..
ew

subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 159-277 2e-12 41.1 In-house 49-181 (349) alignment
Range on Protein: 159-277
Range on HMM: 49-181/349.0
KNKNRYANIVAYDHSRVVLERVN--------------GDEDLDYINASFIHGYDGTP-RSFIASQGPLPPAFEGFWRMVWEQNSQSIVMLTNLVGLNKTK
  |||| .|. |.||||.|..                .    ||||| ...    .. . .|| | ||| . . |....  .. . .. |..   |.  |
faknrykdilPyehsrvklkkslksskvikastsesdsgklddyinanylkltrisvekkyiatqaPlPstvddfykvillngvklvlsLnddkelslek

CHKYWPDktETYGGVTVTLHQSE-VFAGYENCTFI
|..|| .   .| ..|| |  |    |. . ..  
cdiywqe..lsysnitvklqnsslyianvqGnslr

subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 497-611 3.7e-12 40.9 In-house 39-150 (255) alignment
Range on Protein: 497-611
Range on HMM: 39-150/255.0
AtqhplleTVEDFWRMVTDYDIGTIVMLNNLHDQVAPESSEYWPDHGATKYGHIGISVLSKQKKGDVIC----VKPKVTRKKKTHEVRHLHHVSWTDKCI
        ||. |....   .  ..||| .....   . |.|.|     |     ..| . .   ||.     .  ....|||||.|.| ..  | .|  
l.......tvdkfyqtivqtktevvvmlcdfaeegvekcssyfplekdeklkladvnvtttkssadvvlrtleitstlgekkkthtvkhysykGWiekna

PKVSRSVLDLLDEVQTSQQ
|. .| .| .|  |. |. 
Pelareilnilkvvrdsks

subfamily_Sponge-PTP3_pd Subfamily Sponge-PTP3 113-209 1.9e-11 38.0 In-house 3-95 (95) alignment
Range on Protein: 113-209
Range on HMM: 3-95/95.0
KPIPIALFPEYVAKMHGGI--RLETEYKKFNNGQQFPWGAARKPANknKNKNRYANIVAYDHSRVVLErvnGDEDLDYINASFIHGYDGTpRSFIASQG
||| ...|  .| .||      .. |.|  .     |. .    ||    |||. ||. || .||||       | ||||| |. ||      .||.||
kpihvsvfhshvlemhsnsdqefdnefksismtsgapytvgssean..ipknrflnifpydatrvvlt...tkrdsdyinacfvdgyark.ncyiaaqg

subfamily_hpo-7_pd Subfamily hpo-7 497-610 2.7e-11 37.9 In-house 42-155 (263) alignment
Range on Protein: 497-610
Range on HMM: 42-155/263.0
AtqhpLLETVEDFWRMVTDYDIGTIVMLNNLHDQVAPESSEYWPDHGATKYGHIGISVLSKQKKGDVICVKPKVTR----KKKTHEVRHLHHVSWTDKCI
     |..|.. |....      ..||| . ...   . |.|.|     |     ..| . . . ||.    ...     |||||.|.|  .. | .|  
l....lvqtidkfyqtivqtktevvvmLcDfneegvekcssyfPlekdekqklanvnvcttkvqsdvllktlellstlgeKkkthtvkhysykgWieknd

PKVSRSVLDLLDEVQTSQ
|. .|..| .|. .. |.
pelareilnilkvarnsk

subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 446-524 2.8e-11 37.5 In-house 33-116 (347) alignment
Range on Protein: 446-524
Range on HMM: 33-116/347.0
EKPQNLHKNRFSDIIALNSCRVMLHKEH-----ADEESDYINAVFLHAHRGRNAFIATQHPLLETVEDFWRMVTDYDIGTIVML
|  ..| |||  |    .. ||.|  |.     ||.   ||||  ..    .. .| ||.|| .|| |||.||.   .  .| .
ewekslsknrskdvklidatrvvlspeksknsraddvetyinashikfdnaskeyiltqyplpdtvrdfwkmvsvtkvtqvvti

subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 449-524 4.1e-11 37.0 In-house 46-114 (303) alignment
Range on Protein: 449-524
Range on HMM: 46-114/303.0
QNLHKNRFSDIIALNSCRVMLHkehadeESDYINAVFLHAHRGRNAfIATQHPLLETVEDFWRMVTDYDIGTIVML
.|..|||| |.| |.  .| |       .| || | .|. .  ..| | || ||  |  |||.|. .  .  ...|
knmdknrfvdvicldhskvkls......dssyihasyleldsskka.iltqlplshtaadfwqmiieqkvkcvlll

subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 462-622 6e-11 37.0 In-house 30-198 (290) alignment
Range on Protein: 462-622
Range on HMM: 30-198/290.0
LNSCRVMLHKEHADEESDYINAVFLHAHRGRnAFIATQHPLLET-------VEDFWRMVTDYDIGTIVMLNNLHDQVAPE----SSEYWPDHGA--TKYG
..  ||.|.       .||| | ..    |  ..|.|| |. ..       .|.|| |. .  .  .||| . ... |       ..| |..     |..
veatrvvLkgygkrfnddyiHAnrvtcpngl.rliltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCakYvpesvgeelkfk

HIGISVLSKQKKGDVICVKPKVT-RKKKTHEVRHLHHVSWTDKCIPKVSRSVLDLLDEVQTSQqqcgnVPVLVQC
 . ..  || |. ||.  .  |.  ... . | |   ..|..  ... ....|.|.. |..|.      ||.| |
gltvkCkskekeddvetRelvvkfddeeeftvtHsllkgWnklnvqedtktllsliqkvkask.....tpvivHc

subfamily_eak_pd Subfamily eak 324-402 6.6e-11 36.2 In-house 237-317 (332) alignment
Range on Protein: 324-402
Range on HMM: 237-317/332.0
AGPvIVHCSVGVERTGAYIVIDAMLE--QAKKSRTVDIRNYLIAIRKHRPHMVQTKEQYSFIHSAVLEALTCGNTEIQS-EK
  | |. .. |  |.|...||| ...  ..||  .  . .... ....| | | .. |.|||. .||. |   | ...  .|
fap.iiqsarGsaraGvfvvidllirlidnkkknlysvedlilkvkskrihsvlvalqhsfiyeivldyllrrnnrlrdlkk

subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 322-388 1.5e-10 35.4 In-house 260-341 (350) alignment
Range on Protein: 322-388
Range on HMM: 260-341/350.0
RDAGPVIVHCSVGVERTGAYIVIDAMLE-------QAKKSRTVDIRNY--------LIAIRKHRPHMVQTKEQYSFIHSAVL
  . |..|||| || ||| .. .| .|.         |.|| .|  .         .  .|| |  |||...|. ||. |.|
arsspilvhCsaGvGrtGtlvtlDsllsdfeilenltkesrkldvaaktrDlisiivnelrkqrismvqnldqfifiYeall

subfamily_Sponge-PTP-2_pd Subfamily Sponge-PTP-2 157-254 3.4e-10 33.1 In-house 26-90 (169) alignment
Range on Protein: 157-254
Range on HMM: 26-90/169.0
KNKNKNRYANIVAYDHSRVVLERVNGDEDLDYINAsfihgydgtprsfiasqgplppafegfwRMVWEQNSQSIVMLTNLVGLNktkchKYWPDKTET
 |. ||| |  .|  | || |.||  |   |||||                            ||.|| |.  ||.| .    |      .||.| . 
cnetknrpagplapshtrvklqrvmedlgsdyina............................rmiwetnasvivvlgdtddkn.....nfwpekedy

subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 157-302 4e-10 33.7 In-house 95-235 (244) alignment
Range on Protein: 157-302
Range on HMM: 95-235/244.0
KNKNKNRYANIVAYDHSRVVLERvnGDEDLDYINASFIhGYDGTPRSFIASQGPLPPAFEGFWRMVWEQNSQSIVMLTNLvglnkTKCHKYWPDKT--ET
.|  ||| .  . .| .|| | .  |     ||||||. |  |    .| .| ||  .   ||.|. |.  . .|.|  .      .  .||||    | 
nnswknregaglpfdfnrvplsk..gsmgntyinasfv.gclgrtaeyiltqhpladtsmdfwkmmlerhvnvlvvlgsv.....eeedeywpdseplew

YG-GVTVTLHQSEVFAGYENCTFILSKEKRSGSRIVRQFHFTVWPDKGV
|   .|||| . . |       . .  .     . .  |  . ||  | 
yeeditvtltdrdefknikasnleiesdmneshqaltmfqisnwpsdgt

subfamily_Sponge-PTP2_pd Subfamily Sponge-PTP2 157-254 4.1e-10 32.7 In-house 25-89 (169) alignment
Range on Protein: 157-254
Range on HMM: 25-89/169.0
KNKNKNRYANIVAYDHSRVVLERVNGDEDLDYINAsfihgydgtprsfiasqgplppafegfwRMVWEQNSQSIVMLTNLVGLNktkchKYWPDKTET
 |. ||| |  .|  | || |.||  |   |||||                            ||.|| |.  ||.| .    |      .||.| . 
cnetknrpagplapshtrvklqrvmedlgsdyina............................rmiwetnasvivvlGdtddkn.....nfwpekedy

subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 438-542 2.3e-09 31.0 In-house 36-156 (349) alignment
Range on Protein: 438-542
Range on HMM: 36-156/349.0
PVEEKSVGEKPQNLHKNRFSDIIALNSCRVMLHKE--------HADEE------SDYINAVFLHAHRG--RNAFIATQHPLLETVEDFWRMVTDYDIGTI
....  . |  .   |||..||.  .  ||.|.|         ..  |       ||||| .|.  |    . .|||| ||  ||.||.....   .  .
eiddvilseGvelfaknrykdilPyehsrvklkkslksskvikastsesdsgklddyinanylkltrisvekkyiatqaPlPstvddfykvillngvklv

VMLNNLHDQVAPESSEYWPDH
. ||. ...       || . 
lsLnddkelslekcdiywqel

subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 155-231 2.8e-09 31.0 In-house 34-114 (347) alignment
Range on Protein: 155-231
Range on HMM: 34-114/347.0
ANKNKNKNRYANIVAYDHSRVVLERV-----NGDEDLDYINASFIHgYDGTPRSFIASQGPLPPAFEGFWRMVWEQNSQSIV
 .|. .|||  .    | .||||        . |.   ||||| |. .| . . .| .| ||| .   ||.||   .   .|
wekslsknrskdvklidatrvvlspeksknsraddvetyinashik.fdnaskeyiltqyplpdtvrdfwkmvsvtkvtqvv

subfamily_Sponge-PTP-4_pd Subfamily Sponge-PTP-4 477-558 4.3e-09 30.8 In-house 12-88 (130) alignment
Range on Protein: 477-558
Range on HMM: 12-88/130.0
ESDYINAVFLHAHRGRNAFIATQHPLLETVEDFWRMVTDYDIGTIVMLNNLHdqvapESSEYWPDHGATKYGHIGISVLSKQ
. .|||| |.      . .. ||||| .|  |||.|. .  .  .|.|  .      |  |||||    ..    | | . .
gntyinasfvGllgrtaeylltqhpladtsmdfwkmmleryvnvlvvlgsve.....eedeywpdsePlewyeediivtltd

subfamily_Cele-PTP-12_pd Subfamily Cele-PTP-12 157-236 3.4e-08 27.4 In-house 33-110 (332) alignment
Range on Protein: 157-236
Range on HMM: 33-110/332.0
KNKNKNRYANIVAYDHSRVVLERVNGDEdlDYINASFIHGYDGTpRSFIASQGPLPPAFEG-FWRMVWEQNSQSIVMLTNL
.| . ||   . ..||||| |   .| .  |. |||.. ||     ..| .| |.    |  ||||| |..   |... ..
nnmdmnriphlycfdhsrvelapqdgkd..dfynaswvdgyskk.sayifaqapfndhteyvfwrmvserkpsmilvfgdi

subfamily_Cele-PTP-12_pd Subfamily Cele-PTP-12 240-394 4.2e-08 27.0 In-house 146-306 (332) alignment
Range on Protein: 240-394
Range on HMM: 146-306/332.0
NKTKCHKYWPDKTETYGGVTVTLHQSEVFAGYENCTFILSKEKRSGSRIVRQFHFTVWPDK-GVPQYATAVLAFRR--KVRALN--PRDAGPVIVHCSVG
.   |.|.||.|.      ..... |. ..     || |.  ..   .    .||  | |   .|.|   . |  .   .|. .      ||... |. |
kakicrkfwpekrskkdfpalsiqasddhsethmktfnltvtekkqdhqtvlmhfyewadasklpeymldmrasiklqyirsskktgvcigpimlvcatg

VERTGAYIVIDAMLEQAKKSRTVDIRNYLIAIRKHRPHMVQTKEQYSFIHSAVLE-ALTCG
||.   .  || .. .  . . | ... . ||. .|   ..|   ||     ... |.| |
vekcaisatidiivsriteehrvgfketmsaikmqrfgcfrtvgpystacemlmkfavttg

subfamily_Sponge-PTP3_pd Subfamily Sponge-PTP3 443-499 5.7e-08 26.8 In-house 41-94 (95) alignment
Range on Protein: 443-499
Range on HMM: 41-94/95.0
SVGEKPQNLHKNRFSDIIALNSCRVMLHKEhadEESDYINAVFLHAHRGRNAFIATQ
.||    |. |||| .|.  .. ||.|       .||||||.|.  .  .|..||.|
tvgsseanipknrflnifpydatrvvlttk...rdsdyinacfvdgyarkncyiaaq

PTPc_DSPc_SM00012 579-623 7.1e-08 28.0 In-house 2-47 (105) alignment
Range on Protein: 579-623
Range on HMM: 2-47/105.0
VRHLHHVSWTDKCIPKVSRSVLDLLDEVQTSQQQCG-NVPVLVQCR
|.|.|. .|.|...|. | |.|.||..|........ . ||.|.|.
vkhyhytgwpdhgvPeesdsilellravkknknksesskpvvVhCs

subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 203-267 2.1e-07 24.6 In-house 237-300 (440) alignment
Range on Protein: 203-267
Range on HMM: 237-300/440.0
SFIASQGPLPPAFEGFWRMVWEQNSQSIVMLTNlvgLNKTKCHKYWPDKTE--TYGGVTVTLHQSEV
.|||.| ||  .   |||.| . .  .|.|| .   ||   |  ||| .|   |.|  ||  . || 
afiatqmpldstvldfwrlvhdyristiimlnq...lndktcsiywpvntrsvtfgpftvghkgsen

subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 577-623 6.2e-07 23.1 In-house 89-135 (440) alignment
Range on Protein: 577-623
Range on HMM: 89-135/440.0
HEVRHLHHVSWTDKCIPKVSRSVLDLLDEVQTSQQQCGNVPVLVQCR
. ... |. .| || .||..  || ....|. ||...|| |.||.| 
rtlkqyhyqgwpdkgvpkfagpvlkmiqdvnesqekagngpllvhcs

subfamily_Sponge-PTP-4_pd Subfamily Sponge-PTP-4 172-301 6.5e-07 23.7 In-house 7-125 (130) alignment
Range on Protein: 172-301
Range on HMM: 7-125/130.0
HSRVVlervngdeDLDYINASFIhGYDGTPRSFIASQGPLPPAFEGFWRMVWEQNSQSIVMLTNLvglnkTKCHKYWPDKT--ETY-GGVTVTLHQSEVF
 ||.         . .||||||. |  |  . .. .| ||  .   ||.|. |.    .|.|  .      .  .||||    | |   ..||| . . |
vsrlq........gntyinasfv.Gllgrtaeylltqhpladtsmdfwkmmleryvnvlvvlgsv.....eeedeywpdsePlewyeediivtltdrdef

AGYENCTFILSKEKRSGSRIVRQFHFTVWPDKG
   .   .  ...     . .  |. . ||  |
knikasnleiesdlneshqaltmfqisnwpsdg

subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 454-610 9.8e-07 22.8 In-house 47-209 (312) alignment
Range on Protein: 454-610
Range on HMM: 47-209/312.0
NRFSDIIALNSCRVMLhkehADEESDYINAVFLHAHRGRNAFIATQHPLLETVEDFWRMVTDYDIGTIVMLNNLHDQVAPESSEYWPD---------HGA
||. .|   .  |  |    | .|  || | |..     . |..|| || .|.  ||...      .|..|  . .. . ....|  |         |  
nrypniqcwdrgrftl....agdenfyihanfvkictkperfvctqgplentcthfwqlalslgstsiillcgfvedgsekcakyisdivgfvdledhrv

-TKY-GHIGISVLSKQKKGD-VICVKPKVTrkKKTHEVRHLHHVSWTDKCIPKVSRSVLDLLDEVQTSQ
 |.|   | |   ||.|    |. |  | |   .   . |    || |. .|    . | ||  |.  .
yteycteieiggkskdkithrvlkvvvkat..gqesklnhyqwaswpdhgmpdscdtalrllsavkkdk

subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 322-389 1.6e-06 21.7 In-house 263-342 (349) alignment
Range on Protein: 322-389
Range on HMM: 263-342/349.0
RDAGPVIVHCSVGVERTGAYIVIDAMLE----QAKKSRTVDIRN-------YLI-AIRKHRPHMVQTKEQYSFIHSAVLE
 .  ...|||| |  ||| .. .| .|.      ..|  .....       . .  .|| |  |||   |. .|. |.|.
dqlstllvhcsaGcGrtGvlvtldlllsileplqnesnkiklqallkDlisiivnelrkqrismvqnlaqfiaiyealLk

subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 449-540 1.9e-06 21.5 In-house 50-139 (302) alignment
Range on Protein: 449-540
Range on HMM: 50-139/302.0
QNLHKNRFSDIIALNSCRVMLHKEhadeESDYINAVFLHAHRGRNAFIATQHPLLETV---EDFWRMVTDYDIGTIVMLNNLHDQVApESSEYWP
.||.||.  |. .|.| .| |..|    . .|.||  ..    ..  | .| | ....   |.||||| .  | ..|.|    .      ||..|
knlkknqsedvpildsnlvkleae....pdsyvnaskvevPeltrsiilaQlpkvdsedsveeFWrmvfqekivsvvilvgeeelkk.tlselfp

0048179 (Phosphotyrosine protein) phosphatases II 552-624 1.9e-06 23.2 In-house 22-92 (144) alignment
Range on Protein: 552-624
Range on HMM: 22-92/144.0
ISVLSKQKKGDVICVKPKVTRKKKTHEVRHLHHVSWTDKCIPKVSRSVLDLLDEVQTSQQqcGNVPVLVQCRY
.  | |.. . ||.. ..      ..|. ...|..| | ..|  .  .|..|. ... ..   . |||| |..
lellkklgittvinlteeyepefleregiqylhlpwpDhgvpdllellleflefieeale..eggpvlVHCsa

subfamily_PTPDC1_pd Subfamily PTPDC1 292-384 3.1e-06 21.7 In-house 85-169 (182) alignment
Range on Protein: 292-384
Range on HMM: 85-169/182.0
FHFTVWPDKGVPQYATAvLAFRrKVRALNPrDAGPVIVHCSVGVERTGAyiVIDAMLEQAKKsrtVDIRNYLIAIRKHRPHMVQTKEQYSFIH
..   |.| ||.   .. |    || |    . | | |||  |  |||   .| ..|  ||.   ..  . .  .|..||. .||.||  ...
vynfgwkDygvasleri.Ldiv.kvvafal.qegkvavhChaGlGrtGv..liacylvyakr...ltaekaiklvrskrpksiqtreqvelvk

0038934 (Phosphotyrosine protein) phosphatases II 293-385 5.9e-06 21.6 In-house 83-171 (194) alignment
Range on Protein: 293-385
Range on HMM: 83-171/194.0
HFTVWPDKG-VPQYATAVLAFRRKVRALNPRDAGPVIVHCSVGVERTGAYIVIdAMLEqakkSRTVDIRNYLIAIRKHRPHMVQTKEQYSFIHS
.   .||.| ||....    ..   . ||    | | |||  |. |||  ..  ....    ..  . .  .  .|  ||..... .... ...
lklpfpddgtvPsleillrfldlvdeflnedpggvvaVHCkaGlgRtGtlvaa.YLiy....rlgmsaeeAialfrekRpgaipnqdyleallk